id	sid	tid	token	lemma	pos
cord-316534-ep7ezoko	1	1	key	key	NN
cord-316534-ep7ezoko	1	2	:	:	:
cord-316534-ep7ezoko	2	1	cord-316534-ep7ezoko	cord-316534-ep7ezoko	NFP
cord-316534-ep7ezoko	2	2	authors	author	NNS
cord-316534-ep7ezoko	2	3	:	:	:
cord-316534-ep7ezoko	2	4	Gamble	gamble	VB
cord-316534-ep7ezoko	2	5	,	,	,
cord-316534-ep7ezoko	2	6	Lena	Lena	NNP
cord-316534-ep7ezoko	2	7	J	J	NNP
cord-316534-ep7ezoko	2	8	;	;	:
cord-316534-ep7ezoko	2	9	Matthews	Matthews	NNP
cord-316534-ep7ezoko	2	10	,	,	,
cord-316534-ep7ezoko	2	11	Qiana	Qiana	NNP
cord-316534-ep7ezoko	2	12	L	L	NNP
cord-316534-ep7ezoko	2	13	title	title	NN
cord-316534-ep7ezoko	2	14	:	:	:
cord-316534-ep7ezoko	3	1	Current	current	JJ
cord-316534-ep7ezoko	3	2	progress	progress	NN
cord-316534-ep7ezoko	3	3	in	in	IN
cord-316534-ep7ezoko	3	4	the	the	DT
cord-316534-ep7ezoko	3	5	development	development	NN
cord-316534-ep7ezoko	3	6	of	of	IN
cord-316534-ep7ezoko	3	7	a	a	DT
cord-316534-ep7ezoko	3	8	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	3	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	3	10	for	for	IN
cord-316534-ep7ezoko	3	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	3	12	date	date	NN
cord-316534-ep7ezoko	3	13	:	:	:
cord-316534-ep7ezoko	3	14	2010	2010	CD
cord-316534-ep7ezoko	3	15	-	-	SYM
cord-316534-ep7ezoko	3	16	12	12	CD
cord-316534-ep7ezoko	3	17	-	-	SYM
cord-316534-ep7ezoko	3	18	22	22	CD
cord-316534-ep7ezoko	3	19	journal	journal	NN
cord-316534-ep7ezoko	3	20	:	:	:
cord-316534-ep7ezoko	4	1	Drug	Drug	NNP
cord-316534-ep7ezoko	4	2	Des	Des	NNP
cord-316534-ep7ezoko	4	3	Devel	Devel	NNP
cord-316534-ep7ezoko	5	1	Ther	ther	JJ
cord-316534-ep7ezoko	5	2	DOI	doi	NN
cord-316534-ep7ezoko	5	3	:	:	:
cord-316534-ep7ezoko	5	4	10.2147	10.2147	CD
cord-316534-ep7ezoko	5	5	/	/	SYM
cord-316534-ep7ezoko	5	6	dddt.s6959	dddt.s6959	NNS
cord-316534-ep7ezoko	5	7	sha	sha	NNP
cord-316534-ep7ezoko	5	8	:	:	:
cord-316534-ep7ezoko	5	9	16715be315ab1392947070e15252a60ae2b745f8	16715be315ab1392947070e15252a60ae2b745f8	CD
cord-316534-ep7ezoko	5	10	doc_id	doc_id	CD
cord-316534-ep7ezoko	5	11	:	:	:
cord-316534-ep7ezoko	5	12	316534	316534	CD
cord-316534-ep7ezoko	5	13	cord_uid	cord_uid	NNS
cord-316534-ep7ezoko	5	14	:	:	:
cord-316534-ep7ezoko	5	15	ep7ezoko	ep7ezoko	.
cord-316534-ep7ezoko	6	1	Since	since	IN
cord-316534-ep7ezoko	6	2	its	-PRON-	PRP$
cord-316534-ep7ezoko	6	3	discovery	discovery	NN
cord-316534-ep7ezoko	6	4	and	and	CC
cord-316534-ep7ezoko	6	5	characterization	characterization	NN
cord-316534-ep7ezoko	6	6	in	in	IN
cord-316534-ep7ezoko	6	7	the	the	DT
cord-316534-ep7ezoko	6	8	early	early	JJ
cord-316534-ep7ezoko	6	9	1980s	1980s	CD
cord-316534-ep7ezoko	6	10	as	as	IN
cord-316534-ep7ezoko	6	11	a	a	DT
cord-316534-ep7ezoko	6	12	virus	virus	NN
cord-316534-ep7ezoko	6	13	that	that	WDT
cord-316534-ep7ezoko	6	14	attacks	attack	VBZ
cord-316534-ep7ezoko	6	15	the	the	DT
cord-316534-ep7ezoko	6	16	immune	immune	JJ
cord-316534-ep7ezoko	6	17	system	system	NN
cord-316534-ep7ezoko	6	18	,	,	,
cord-316534-ep7ezoko	6	19	there	there	EX
cord-316534-ep7ezoko	6	20	has	have	VBZ
cord-316534-ep7ezoko	6	21	been	be	VBN
cord-316534-ep7ezoko	6	22	some	some	DT
cord-316534-ep7ezoko	6	23	success	success	NN
cord-316534-ep7ezoko	6	24	for	for	IN
cord-316534-ep7ezoko	6	25	the	the	DT
cord-316534-ep7ezoko	6	26	treatment	treatment	NN
cord-316534-ep7ezoko	6	27	of	of	IN
cord-316534-ep7ezoko	6	28	human	human	JJ
cord-316534-ep7ezoko	6	29	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	6	30	virus-1	virus-1	NN
cord-316534-ep7ezoko	6	31	(	(	-LRB-
cord-316534-ep7ezoko	6	32	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	6	33	)	)	-RRB-
cord-316534-ep7ezoko	6	34	infection	infection	NN
cord-316534-ep7ezoko	6	35	.	.	.
cord-316534-ep7ezoko	7	1	However	however	RB
cord-316534-ep7ezoko	7	2	,	,	,
cord-316534-ep7ezoko	7	3	due	due	IN
cord-316534-ep7ezoko	7	4	to	to	IN
cord-316534-ep7ezoko	7	5	the	the	DT
cord-316534-ep7ezoko	7	6	overwhelming	overwhelming	JJ
cord-316534-ep7ezoko	7	7	public	public	JJ
cord-316534-ep7ezoko	7	8	health	health	NN
cord-316534-ep7ezoko	7	9	impact	impact	NN
cord-316534-ep7ezoko	7	10	of	of	IN
cord-316534-ep7ezoko	7	11	this	this	DT
cord-316534-ep7ezoko	7	12	virus	virus	NN
cord-316534-ep7ezoko	7	13	,	,	,
cord-316534-ep7ezoko	7	14	a	a	DT
cord-316534-ep7ezoko	7	15	vaccine	vaccine	NN
cord-316534-ep7ezoko	7	16	is	be	VBZ
cord-316534-ep7ezoko	7	17	needed	need	VBN
cord-316534-ep7ezoko	7	18	urgently	urgently	RB
cord-316534-ep7ezoko	7	19	.	.	.
cord-316534-ep7ezoko	8	1	Despite	despite	IN
cord-316534-ep7ezoko	8	2	the	the	DT
cord-316534-ep7ezoko	8	3	tireless	tireless	JJ
cord-316534-ep7ezoko	8	4	efforts	effort	NNS
cord-316534-ep7ezoko	8	5	of	of	IN
cord-316534-ep7ezoko	8	6	scientist	scientist	NN
cord-316534-ep7ezoko	8	7	and	and	CC
cord-316534-ep7ezoko	8	8	clinicians	clinician	NNS
cord-316534-ep7ezoko	8	9	,	,	,
cord-316534-ep7ezoko	8	10	there	there	EX
cord-316534-ep7ezoko	8	11	is	be	VBZ
cord-316534-ep7ezoko	8	12	still	still	RB
cord-316534-ep7ezoko	8	13	no	no	DT
cord-316534-ep7ezoko	8	14	safe	safe	JJ
cord-316534-ep7ezoko	8	15	and	and	CC
cord-316534-ep7ezoko	8	16	effective	effective	JJ
cord-316534-ep7ezoko	8	17	vaccine	vaccine	NN
cord-316534-ep7ezoko	8	18	that	that	WDT
cord-316534-ep7ezoko	8	19	provides	provide	VBZ
cord-316534-ep7ezoko	8	20	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	8	21	immunity	immunity	NN
cord-316534-ep7ezoko	8	22	.	.	.
cord-316534-ep7ezoko	9	1	A	a	DT
cord-316534-ep7ezoko	9	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	9	3	that	that	WDT
cord-316534-ep7ezoko	9	4	provides	provide	VBZ
cord-316534-ep7ezoko	9	5	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	9	6	immunity	immunity	NN
cord-316534-ep7ezoko	9	7	against	against	IN
cord-316534-ep7ezoko	9	8	HIV	HIV	NNP
cord-316534-ep7ezoko	9	9	infection	infection	NN
cord-316534-ep7ezoko	9	10	remains	remain	VBZ
cord-316534-ep7ezoko	9	11	elusive	elusive	JJ
cord-316534-ep7ezoko	9	12	in	in	IN
cord-316534-ep7ezoko	9	13	part	part	NN
cord-316534-ep7ezoko	9	14	due	due	IN
cord-316534-ep7ezoko	9	15	to	to	IN
cord-316534-ep7ezoko	9	16	the	the	DT
cord-316534-ep7ezoko	9	17	following	follow	VBG
cord-316534-ep7ezoko	9	18	reasons	reason	NNS
cord-316534-ep7ezoko	9	19	:	:	:
cord-316534-ep7ezoko	9	20	1	1	LS
cord-316534-ep7ezoko	9	21	)	)	-RRB-
cord-316534-ep7ezoko	9	22	degree	degree	NN
cord-316534-ep7ezoko	9	23	of	of	IN
cord-316534-ep7ezoko	9	24	diversity	diversity	NN
cord-316534-ep7ezoko	9	25	of	of	IN
cord-316534-ep7ezoko	9	26	the	the	DT
cord-316534-ep7ezoko	9	27	virus	virus	NN
cord-316534-ep7ezoko	9	28	,	,	,
cord-316534-ep7ezoko	9	29	2	2	LS
cord-316534-ep7ezoko	9	30	)	)	-RRB-
cord-316534-ep7ezoko	9	31	ability	ability	NN
cord-316534-ep7ezoko	9	32	of	of	IN
cord-316534-ep7ezoko	9	33	the	the	DT
cord-316534-ep7ezoko	9	34	virus	virus	NN
cord-316534-ep7ezoko	9	35	to	to	TO
cord-316534-ep7ezoko	9	36	evade	evade	VB
cord-316534-ep7ezoko	9	37	the	the	DT
cord-316534-ep7ezoko	9	38	hosts	host	NNS
cord-316534-ep7ezoko	9	39	’	’	POS
cord-316534-ep7ezoko	9	40	immunity	immunity	NN
cord-316534-ep7ezoko	9	41	,	,	,
cord-316534-ep7ezoko	9	42	and	and	CC
cord-316534-ep7ezoko	9	43	3	3	LS
cord-316534-ep7ezoko	9	44	)	)	-RRB-
cord-316534-ep7ezoko	9	45	lack	lack	NN
cord-316534-ep7ezoko	9	46	of	of	IN
cord-316534-ep7ezoko	9	47	appropriate	appropriate	JJ
cord-316534-ep7ezoko	9	48	animal	animal	NN
cord-316534-ep7ezoko	9	49	models	model	NNS
cord-316534-ep7ezoko	9	50	in	in	IN
cord-316534-ep7ezoko	9	51	which	which	WDT
cord-316534-ep7ezoko	9	52	to	to	TO
cord-316534-ep7ezoko	9	53	test	test	VB
cord-316534-ep7ezoko	9	54	vaccine	vaccine	NN
cord-316534-ep7ezoko	9	55	candidates	candidate	NNS
cord-316534-ep7ezoko	9	56	.	.	.
cord-316534-ep7ezoko	10	1	There	there	EX
cord-316534-ep7ezoko	10	2	have	have	VBP
cord-316534-ep7ezoko	10	3	been	be	VBN
cord-316534-ep7ezoko	10	4	several	several	JJ
cord-316534-ep7ezoko	10	5	attempts	attempt	NNS
cord-316534-ep7ezoko	10	6	to	to	TO
cord-316534-ep7ezoko	10	7	stimulate	stimulate	VB
cord-316534-ep7ezoko	10	8	the	the	DT
cord-316534-ep7ezoko	10	9	immune	immune	JJ
cord-316534-ep7ezoko	10	10	system	system	NN
cord-316534-ep7ezoko	10	11	to	to	TO
cord-316534-ep7ezoko	10	12	provide	provide	VB
cord-316534-ep7ezoko	10	13	protection	protection	NN
cord-316534-ep7ezoko	10	14	against	against	IN
cord-316534-ep7ezoko	10	15	HIV	HIV	NNP
cord-316534-ep7ezoko	10	16	-	-	HYPH
cord-316534-ep7ezoko	10	17	infection	infection	NN
cord-316534-ep7ezoko	10	18	.	.	.
cord-316534-ep7ezoko	11	1	Here	here	RB
cord-316534-ep7ezoko	11	2	,	,	,
cord-316534-ep7ezoko	11	3	we	-PRON-	PRP
cord-316534-ep7ezoko	11	4	will	will	MD
cord-316534-ep7ezoko	11	5	discuss	discuss	VB
cord-316534-ep7ezoko	11	6	attempts	attempt	NNS
cord-316534-ep7ezoko	11	7	that	that	WDT
cord-316534-ep7ezoko	11	8	have	have	VBP
cord-316534-ep7ezoko	11	9	been	be	VBN
cord-316534-ep7ezoko	11	10	made	make	VBN
cord-316534-ep7ezoko	11	11	to	to	TO
cord-316534-ep7ezoko	11	12	induce	induce	VB
cord-316534-ep7ezoko	11	13	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	11	14	immunity	immunity	NN
cord-316534-ep7ezoko	11	15	,	,	,
cord-316534-ep7ezoko	11	16	including	include	VBG
cord-316534-ep7ezoko	11	17	traditional	traditional	JJ
cord-316534-ep7ezoko	11	18	vaccination	vaccination	NN
cord-316534-ep7ezoko	11	19	attempts	attempt	NNS
cord-316534-ep7ezoko	11	20	,	,	,
cord-316534-ep7ezoko	11	21	induction	induction	NN
cord-316534-ep7ezoko	11	22	of	of	IN
cord-316534-ep7ezoko	11	23	broadly	broadly	RB
cord-316534-ep7ezoko	11	24	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	11	25	antibody	antibody	NN
cord-316534-ep7ezoko	11	26	production	production	NN
cord-316534-ep7ezoko	11	27	,	,	,
cord-316534-ep7ezoko	11	28	DNA	dna	NN
cord-316534-ep7ezoko	11	29	vaccines	vaccine	NNS
cord-316534-ep7ezoko	11	30	,	,	,
cord-316534-ep7ezoko	11	31	and	and	CC
cord-316534-ep7ezoko	11	32	use	use	NN
cord-316534-ep7ezoko	11	33	of	of	IN
cord-316534-ep7ezoko	11	34	viral	viral	JJ
cord-316534-ep7ezoko	11	35	vectors	vector	NNS
cord-316534-ep7ezoko	11	36	.	.	.
cord-316534-ep7ezoko	12	1	Some	some	DT
cord-316534-ep7ezoko	12	2	of	of	IN
cord-316534-ep7ezoko	12	3	these	these	DT
cord-316534-ep7ezoko	12	4	attempts	attempt	NNS
cord-316534-ep7ezoko	12	5	show	show	VBP
cord-316534-ep7ezoko	12	6	promise	promise	NN
cord-316534-ep7ezoko	12	7	pending	pende	VBG
cord-316534-ep7ezoko	12	8	continued	continued	JJ
cord-316534-ep7ezoko	12	9	research	research	NN
cord-316534-ep7ezoko	12	10	efforts	effort	NNS
cord-316534-ep7ezoko	12	11	.	.	.
cord-316534-ep7ezoko	13	1	Since	since	IN
cord-316534-ep7ezoko	13	2	its	-PRON-	PRP$
cord-316534-ep7ezoko	13	3	discovery	discovery	NN
cord-316534-ep7ezoko	13	4	and	and	CC
cord-316534-ep7ezoko	13	5	characterization	characterization	NN
cord-316534-ep7ezoko	13	6	in	in	IN
cord-316534-ep7ezoko	13	7	the	the	DT
cord-316534-ep7ezoko	13	8	early	early	JJ
cord-316534-ep7ezoko	13	9	1980s	1980s	CD
cord-316534-ep7ezoko	13	10	as	as	IN
cord-316534-ep7ezoko	13	11	a	a	DT
cord-316534-ep7ezoko	13	12	virus	virus	NN
cord-316534-ep7ezoko	13	13	that	that	WDT
cord-316534-ep7ezoko	13	14	attacks	attack	VBZ
cord-316534-ep7ezoko	13	15	the	the	DT
cord-316534-ep7ezoko	13	16	immune	immune	JJ
cord-316534-ep7ezoko	13	17	system	system	NN
cord-316534-ep7ezoko	13	18	,	,	,
cord-316534-ep7ezoko	13	19	leaving	leave	VBG
cord-316534-ep7ezoko	13	20	patients	patient	NNS
cord-316534-ep7ezoko	13	21	unable	unable	JJ
cord-316534-ep7ezoko	13	22	to	to	TO
cord-316534-ep7ezoko	13	23	fight	fight	VB
cord-316534-ep7ezoko	13	24	off	off	RP
cord-316534-ep7ezoko	13	25	opportunistic	opportunistic	JJ
cord-316534-ep7ezoko	13	26	infections	infection	NNS
cord-316534-ep7ezoko	13	27	,	,	,
cord-316534-ep7ezoko	13	28	there	there	EX
cord-316534-ep7ezoko	13	29	has	have	VBZ
cord-316534-ep7ezoko	13	30	been	be	VBN
cord-316534-ep7ezoko	13	31	an	an	DT
cord-316534-ep7ezoko	13	32	ebb	ebb	NN
cord-316534-ep7ezoko	13	33	and	and	CC
cord-316534-ep7ezoko	13	34	flow	flow	NN
cord-316534-ep7ezoko	13	35	of	of	IN
cord-316534-ep7ezoko	13	36	effective	effective	JJ
cord-316534-ep7ezoko	13	37	treatments	treatment	NNS
cord-316534-ep7ezoko	13	38	and	and	CC
cord-316534-ep7ezoko	13	39	hope	hope	NN
cord-316534-ep7ezoko	13	40	as	as	IN
cord-316534-ep7ezoko	13	41	scientists	scientist	NNS
cord-316534-ep7ezoko	13	42	continue	continue	VBP
cord-316534-ep7ezoko	13	43	to	to	TO
cord-316534-ep7ezoko	13	44	search	search	VB
cord-316534-ep7ezoko	13	45	for	for	IN
cord-316534-ep7ezoko	13	46	ways	way	NNS
cord-316534-ep7ezoko	13	47	to	to	TO
cord-316534-ep7ezoko	13	48	eradicate	eradicate	VB
cord-316534-ep7ezoko	13	49	human	human	JJ
cord-316534-ep7ezoko	13	50	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	13	51	virus-1	virus-1	NN
cord-316534-ep7ezoko	13	52	(	(	-LRB-
cord-316534-ep7ezoko	13	53	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	13	54	)	)	-RRB-
cord-316534-ep7ezoko	13	55	from	from	IN
cord-316534-ep7ezoko	13	56	the	the	DT
cord-316534-ep7ezoko	13	57	human	human	JJ
cord-316534-ep7ezoko	13	58	population	population	NN
cord-316534-ep7ezoko	13	59	similar	similar	JJ
cord-316534-ep7ezoko	13	60	to	to	IN
cord-316534-ep7ezoko	13	61	what	what	WP
cord-316534-ep7ezoko	13	62	has	have	VBZ
cord-316534-ep7ezoko	13	63	been	be	VBN
cord-316534-ep7ezoko	13	64	accomplished	accomplish	VBN
cord-316534-ep7ezoko	13	65	in	in	IN
cord-316534-ep7ezoko	13	66	the	the	DT
cord-316534-ep7ezoko	13	67	case	case	NN
cord-316534-ep7ezoko	13	68	of	of	IN
cord-316534-ep7ezoko	13	69	smallpox	smallpox	NN
cord-316534-ep7ezoko	13	70	.	.	.
cord-316534-ep7ezoko	14	1	The	the	DT
cord-316534-ep7ezoko	14	2	majority	majority	NN
cord-316534-ep7ezoko	14	3	of	of	IN
cord-316534-ep7ezoko	14	4	the	the	DT
cord-316534-ep7ezoko	14	5	effort	effort	NN
cord-316534-ep7ezoko	14	6	and	and	CC
cord-316534-ep7ezoko	14	7	nearly	nearly	RB
cord-316534-ep7ezoko	14	8	all	all	DT
cord-316534-ep7ezoko	14	9	of	of	IN
cord-316534-ep7ezoko	14	10	the	the	DT
cord-316534-ep7ezoko	14	11	success	success	NN
cord-316534-ep7ezoko	14	12	has	have	VBZ
cord-316534-ep7ezoko	14	13	come	come	VBN
cord-316534-ep7ezoko	14	14	in	in	IN
cord-316534-ep7ezoko	14	15	the	the	DT
cord-316534-ep7ezoko	14	16	area	area	NN
cord-316534-ep7ezoko	14	17	of	of	IN
cord-316534-ep7ezoko	14	18	patient	patient	JJ
cord-316534-ep7ezoko	14	19	treatment	treatment	NN
cord-316534-ep7ezoko	14	20	rather	rather	RB
cord-316534-ep7ezoko	14	21	than	than	IN
cord-316534-ep7ezoko	14	22	inhibition	inhibition	NN
cord-316534-ep7ezoko	14	23	of	of	IN
cord-316534-ep7ezoko	14	24	contraction	contraction	NN
cord-316534-ep7ezoko	14	25	or	or	CC
cord-316534-ep7ezoko	14	26	spread	spread	NN
cord-316534-ep7ezoko	14	27	of	of	IN
cord-316534-ep7ezoko	14	28	the	the	DT
cord-316534-ep7ezoko	14	29	virus	virus	NN
cord-316534-ep7ezoko	14	30	.	.	.
cord-316534-ep7ezoko	15	1	A	a	DT
cord-316534-ep7ezoko	15	2	class	class	NN
cord-316534-ep7ezoko	15	3	of	of	IN
cord-316534-ep7ezoko	15	4	treatments	treatment	NNS
cord-316534-ep7ezoko	15	5	,	,	,
cord-316534-ep7ezoko	15	6	antiretroviral	antiretroviral	JJ
cord-316534-ep7ezoko	15	7	therapies	therapy	NNS
cord-316534-ep7ezoko	15	8	(	(	-LRB-
cord-316534-ep7ezoko	15	9	ARTs	art	NNS
cord-316534-ep7ezoko	15	10	)	)	-RRB-
cord-316534-ep7ezoko	15	11	and	and	CC
cord-316534-ep7ezoko	15	12	later	later	RB
cord-316534-ep7ezoko	15	13	highly	highly	RB
cord-316534-ep7ezoko	15	14	active	active	JJ
cord-316534-ep7ezoko	15	15	antiretroviral	antiretroviral	JJ
cord-316534-ep7ezoko	15	16	therapies	therapy	NNS
cord-316534-ep7ezoko	15	17	(	(	-LRB-
cord-316534-ep7ezoko	15	18	HAARTs	haart	NNS
cord-316534-ep7ezoko	15	19	)	)	-RRB-
cord-316534-ep7ezoko	15	20	,	,	,
cord-316534-ep7ezoko	15	21	has	have	VBZ
cord-316534-ep7ezoko	15	22	been	be	VBN
cord-316534-ep7ezoko	15	23	the	the	DT
cord-316534-ep7ezoko	15	24	mainstay	mainstay	NN
cord-316534-ep7ezoko	15	25	of	of	IN
cord-316534-ep7ezoko	15	26	disease	disease	NN
cord-316534-ep7ezoko	15	27	control	control	NN
cord-316534-ep7ezoko	15	28	during	during	IN
cord-316534-ep7ezoko	15	29	the	the	DT
cord-316534-ep7ezoko	15	30	last	last	JJ
cord-316534-ep7ezoko	15	31	15	15	CD
cord-316534-ep7ezoko	15	32	years	year	NNS
cord-316534-ep7ezoko	15	33	.	.	.
cord-316534-ep7ezoko	16	1	Notwithstanding	notwithstanding	IN
cord-316534-ep7ezoko	16	2	the	the	DT
cord-316534-ep7ezoko	16	3	increased	increase	VBN
cord-316534-ep7ezoko	16	4	life	life	NN
cord-316534-ep7ezoko	16	5	span	span	NN
cord-316534-ep7ezoko	16	6	of	of	IN
cord-316534-ep7ezoko	16	7	patients	patient	NNS
cord-316534-ep7ezoko	16	8	,	,	,
cord-316534-ep7ezoko	16	9	increased	increase	VBN
cord-316534-ep7ezoko	16	10	time	time	NN
cord-316534-ep7ezoko	16	11	to	to	IN
cord-316534-ep7ezoko	16	12	full	full	RB
cord-316534-ep7ezoko	16	13	-	-	HYPH
cord-316534-ep7ezoko	16	14	blown	blown	JJ
cord-316534-ep7ezoko	16	15	AIDS	AIDS	NNP
cord-316534-ep7ezoko	16	16	,	,	,
cord-316534-ep7ezoko	16	17	and	and	CC
cord-316534-ep7ezoko	16	18	decreased	decrease	VBD
cord-316534-ep7ezoko	16	19	contraction	contraction	NN
cord-316534-ep7ezoko	16	20	of	of	IN
cord-316534-ep7ezoko	16	21	opportunistic	opportunistic	JJ
cord-316534-ep7ezoko	16	22	infections	infection	NNS
cord-316534-ep7ezoko	16	23	and	and	CC
cord-316534-ep7ezoko	16	24	AIDS	AIDS	NNP
cord-316534-ep7ezoko	16	25	-	-	HYPH
cord-316534-ep7ezoko	16	26	related	relate	VBN
cord-316534-ep7ezoko	16	27	diseases	disease	NNS
cord-316534-ep7ezoko	16	28	(	(	-LRB-
cord-316534-ep7ezoko	16	29	ie	ie	FW
cord-316534-ep7ezoko	16	30	,	,	,
cord-316534-ep7ezoko	16	31	non	non	JJ
cord-316534-ep7ezoko	16	32	-	-	NNP
cord-316534-ep7ezoko	16	33	Hodgkin	Hodgkin	NNP
cord-316534-ep7ezoko	16	34	's	's	POS
cord-316534-ep7ezoko	16	35	lymphoma	lymphoma	NN
cord-316534-ep7ezoko	16	36	,	,	,
cord-316534-ep7ezoko	16	37	Kaposi	Kaposi	NNP
cord-316534-ep7ezoko	16	38	's	's	POS
cord-316534-ep7ezoko	16	39	sarcoma	sarcoma	NN
cord-316534-ep7ezoko	16	40	,	,	,
cord-316534-ep7ezoko	16	41	etc	etc	FW
cord-316534-ep7ezoko	16	42	)	)	-RRB-
cord-316534-ep7ezoko	16	43	by	by	IN
cord-316534-ep7ezoko	16	44	patients	patient	NNS
cord-316534-ep7ezoko	16	45	treated	treat	VBN
cord-316534-ep7ezoko	16	46	with	with	IN
cord-316534-ep7ezoko	16	47	HAART	HAART	NNP
cord-316534-ep7ezoko	16	48	,	,	,
cord-316534-ep7ezoko	16	49	there	there	EX
cord-316534-ep7ezoko	16	50	are	be	VBP
cord-316534-ep7ezoko	16	51	several	several	JJ
cord-316534-ep7ezoko	16	52	reasons	reason	NNS
cord-316534-ep7ezoko	16	53	why	why	WRB
cord-316534-ep7ezoko	16	54	development	development	NN
cord-316534-ep7ezoko	16	55	of	of	IN
cord-316534-ep7ezoko	16	56	an	an	DT
cord-316534-ep7ezoko	16	57	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	16	58	vaccine	vaccine	NN
cord-316534-ep7ezoko	16	59	is	be	VBZ
cord-316534-ep7ezoko	16	60	still	still	RB
cord-316534-ep7ezoko	16	61	warranted	warrant	VBN
cord-316534-ep7ezoko	16	62	.	.	.
cord-316534-ep7ezoko	17	1	Five	five	CD
cord-316534-ep7ezoko	17	2	of	of	IN
cord-316534-ep7ezoko	17	3	these	these	DT
cord-316534-ep7ezoko	17	4	reasons	reason	NNS
cord-316534-ep7ezoko	17	5	are	be	VBP
cord-316534-ep7ezoko	17	6	as	as	IN
cord-316534-ep7ezoko	17	7	follows	follow	VBZ
cord-316534-ep7ezoko	17	8	:	:	:
cord-316534-ep7ezoko	17	9	1	1	LS
cord-316534-ep7ezoko	17	10	)	)	-RRB-
cord-316534-ep7ezoko	17	11	nearly	nearly	RB
cord-316534-ep7ezoko	17	12	two	two	CD
cord-316534-ep7ezoko	17	13	-	-	HYPH
cord-316534-ep7ezoko	17	14	thirds	third	NNS
cord-316534-ep7ezoko	17	15	of	of	IN
cord-316534-ep7ezoko	17	16	the	the	DT
cord-316534-ep7ezoko	17	17	patients	patient	NNS
cord-316534-ep7ezoko	17	18	who	who	WP
cord-316534-ep7ezoko	17	19	contract	contract	VBP
cord-316534-ep7ezoko	17	20	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	17	21	live	live	VBP
cord-316534-ep7ezoko	17	22	in	in	IN
cord-316534-ep7ezoko	17	23	underdeveloped	underdeveloped	JJ
cord-316534-ep7ezoko	17	24	countries	country	NNS
cord-316534-ep7ezoko	17	25	and	and	CC
cord-316534-ep7ezoko	17	26	can	can	MD
cord-316534-ep7ezoko	17	27	not	not	RB
cord-316534-ep7ezoko	17	28	afford	afford	VB
cord-316534-ep7ezoko	17	29	the	the	DT
cord-316534-ep7ezoko	17	30	expensive	expensive	JJ
cord-316534-ep7ezoko	17	31	HAART	HAART	NNP
cord-316534-ep7ezoko	17	32	regimen	regimen	NN
cord-316534-ep7ezoko	17	33	,	,	,
cord-316534-ep7ezoko	17	34	1	1	CD
cord-316534-ep7ezoko	17	35	2	2	CD
cord-316534-ep7ezoko	17	36	)	)	-RRB-
cord-316534-ep7ezoko	17	37	both	both	CC
cord-316534-ep7ezoko	17	38	the	the	DT
cord-316534-ep7ezoko	17	39	ART	ART	NNP
cord-316534-ep7ezoko	17	40	and	and	CC
cord-316534-ep7ezoko	17	41	HAART	HAART	NNP
cord-316534-ep7ezoko	17	42	regimen	regimen	NN
cord-316534-ep7ezoko	17	43	are	be	VBP
cord-316534-ep7ezoko	17	44	complex	complex	JJ
cord-316534-ep7ezoko	17	45	and	and	CC
cord-316534-ep7ezoko	17	46	are	be	VBP
cord-316534-ep7ezoko	17	47	disruptive	disruptive	JJ
cord-316534-ep7ezoko	17	48	to	to	IN
cord-316534-ep7ezoko	17	49	patients	patient	NNS
cord-316534-ep7ezoko	17	50	'	'	POS
cord-316534-ep7ezoko	17	51	lives	life	NNS
cord-316534-ep7ezoko	17	52	and	and	CC
cord-316534-ep7ezoko	17	53	diets	diet	NNS
cord-316534-ep7ezoko	17	54	,	,	,
cord-316534-ep7ezoko	17	55	making	make	VBG
cord-316534-ep7ezoko	17	56	long	long	JJ
cord-316534-ep7ezoko	17	57	-	-	HYPH
cord-316534-ep7ezoko	17	58	term	term	NN
cord-316534-ep7ezoko	17	59	compliance	compliance	NN
cord-316534-ep7ezoko	17	60	an	an	DT
cord-316534-ep7ezoko	17	61	issue	issue	NN
cord-316534-ep7ezoko	17	62	,	,	,
cord-316534-ep7ezoko	17	63	2	2	CD
cord-316534-ep7ezoko	17	64	3	3	CD
cord-316534-ep7ezoko	17	65	)	)	-RRB-
cord-316534-ep7ezoko	17	66	the	the	DT
cord-316534-ep7ezoko	17	67	potential	potential	JJ
cord-316534-ep7ezoko	17	68	side	side	NN
cord-316534-ep7ezoko	17	69	effects	effect	NNS
cord-316534-ep7ezoko	17	70	of	of	IN
cord-316534-ep7ezoko	17	71	ART	art	NN
cord-316534-ep7ezoko	17	72	/	/	SYM
cord-316534-ep7ezoko	17	73	HAART	HAART	NNP
cord-316534-ep7ezoko	17	74	treatments	treatment	NNS
cord-316534-ep7ezoko	17	75	negatively	negatively	RB
cord-316534-ep7ezoko	17	76	affect	affect	VBP
cord-316534-ep7ezoko	17	77	the	the	DT
cord-316534-ep7ezoko	17	78	long	long	JJ
cord-316534-ep7ezoko	17	79	-	-	HYPH
cord-316534-ep7ezoko	17	80	term	term	NN
cord-316534-ep7ezoko	17	81	health	health	NN
cord-316534-ep7ezoko	17	82	of	of	IN
cord-316534-ep7ezoko	17	83	patients	patient	NNS
cord-316534-ep7ezoko	17	84	and	and	CC
cord-316534-ep7ezoko	17	85	include	include	VBP
cord-316534-ep7ezoko	17	86	diabetes	diabetes	NN
cord-316534-ep7ezoko	17	87	,	,	,
cord-316534-ep7ezoko	17	88	cardiovascular	cardiovascular	JJ
cord-316534-ep7ezoko	17	89	disease	disease	NN
cord-316534-ep7ezoko	17	90	,	,	,
cord-316534-ep7ezoko	17	91	fractures	fracture	NNS
cord-316534-ep7ezoko	17	92	,	,	,
cord-316534-ep7ezoko	17	93	etc	etc	FW
cord-316534-ep7ezoko	17	94	,	,	,
cord-316534-ep7ezoko	17	95	3	3	CD
cord-316534-ep7ezoko	17	96	-	-	SYM
cord-316534-ep7ezoko	17	97	5	5	CD
cord-316534-ep7ezoko	17	98	4	4	CD
cord-316534-ep7ezoko	17	99	)	)	-RRB-
cord-316534-ep7ezoko	17	100	development	development	NN
cord-316534-ep7ezoko	17	101	of	of	IN
cord-316534-ep7ezoko	17	102	HAART	HAART	NNP
cord-316534-ep7ezoko	17	103	drug	drug	NN
cord-316534-ep7ezoko	17	104	resistance	resistance	NN
cord-316534-ep7ezoko	17	105	,	,	,
cord-316534-ep7ezoko	17	106	and	and	CC
cord-316534-ep7ezoko	17	107	5	5	LS
cord-316534-ep7ezoko	17	108	)	)	-RRB-
cord-316534-ep7ezoko	17	109	the	the	DT
cord-316534-ep7ezoko	17	110	presence	presence	NN
cord-316534-ep7ezoko	17	111	of	of	IN
cord-316534-ep7ezoko	17	112	latent	latent	JJ
cord-316534-ep7ezoko	17	113	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	17	114	reservoirs	reservoir	NNS
cord-316534-ep7ezoko	17	115	harboring	harbor	VBG
cord-316534-ep7ezoko	17	116	viral	viral	JJ
cord-316534-ep7ezoko	17	117	strains	strain	NNS
cord-316534-ep7ezoko	17	118	that	that	WDT
cord-316534-ep7ezoko	17	119	were	be	VBD
cord-316534-ep7ezoko	17	120	produced	produce	VBN
cord-316534-ep7ezoko	17	121	through	through	IN
cord-316534-ep7ezoko	17	122	mutation	mutation	NN
cord-316534-ep7ezoko	17	123	throughout	throughout	IN
cord-316534-ep7ezoko	17	124	the	the	DT
cord-316534-ep7ezoko	17	125	duration	duration	NN
cord-316534-ep7ezoko	17	126	of	of	IN
cord-316534-ep7ezoko	17	127	the	the	DT
cord-316534-ep7ezoko	17	128	infection	infection	NN
cord-316534-ep7ezoko	17	129	of	of	IN
cord-316534-ep7ezoko	17	130	the	the	DT
cord-316534-ep7ezoko	17	131	host	host	NN
cord-316534-ep7ezoko	17	132	also	also	RB
cord-316534-ep7ezoko	17	133	play	play	VBP
cord-316534-ep7ezoko	17	134	a	a	DT
cord-316534-ep7ezoko	17	135	role	role	NN
cord-316534-ep7ezoko	17	136	in	in	IN
cord-316534-ep7ezoko	17	137	the	the	DT
cord-316534-ep7ezoko	17	138	failure	failure	NN
cord-316534-ep7ezoko	17	139	of	of	IN
cord-316534-ep7ezoko	17	140	HAART	HAART	NNP
cord-316534-ep7ezoko	17	141	.	.	.
cord-316534-ep7ezoko	18	1	6	6	CD
cord-316534-ep7ezoko	19	1	These	these	DT
cord-316534-ep7ezoko	19	2	reasons	reason	NNS
cord-316534-ep7ezoko	19	3	,	,	,
cord-316534-ep7ezoko	19	4	as	as	RB
cord-316534-ep7ezoko	19	5	well	well	RB
cord-316534-ep7ezoko	19	6	as	as	IN
cord-316534-ep7ezoko	19	7	many	many	JJ
cord-316534-ep7ezoko	19	8	others	other	NNS
cord-316534-ep7ezoko	19	9	,	,	,
cord-316534-ep7ezoko	19	10	underscore	underscore	VB
cord-316534-ep7ezoko	19	11	the	the	DT
cord-316534-ep7ezoko	19	12	need	need	NN
cord-316534-ep7ezoko	19	13	for	for	IN
cord-316534-ep7ezoko	19	14	a	a	DT
cord-316534-ep7ezoko	19	15	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	19	16	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	19	17	vaccine	vaccine	NN
cord-316534-ep7ezoko	19	18	.	.	.
cord-316534-ep7ezoko	20	1	Possibly	possibly	RB
cord-316534-ep7ezoko	20	2	,	,	,
cord-316534-ep7ezoko	20	3	the	the	DT
cord-316534-ep7ezoko	20	4	strongest	strong	JJS
cord-316534-ep7ezoko	20	5	argument	argument	NN
cord-316534-ep7ezoko	20	6	for	for	IN
cord-316534-ep7ezoko	20	7	development	development	NN
cord-316534-ep7ezoko	20	8	of	of	IN
cord-316534-ep7ezoko	20	9	a	a	DT
cord-316534-ep7ezoko	20	10	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	20	11	vaccine	vaccine	NN
cord-316534-ep7ezoko	20	12	may	may	MD
cord-316534-ep7ezoko	20	13	be	be	VB
cord-316534-ep7ezoko	20	14	the	the	DT
cord-316534-ep7ezoko	20	15	need	need	NN
cord-316534-ep7ezoko	20	16	for	for	IN
cord-316534-ep7ezoko	20	17	control	control	NN
cord-316534-ep7ezoko	20	18	of	of	IN
cord-316534-ep7ezoko	20	19	the	the	DT
cord-316534-ep7ezoko	20	20	virus	virus	NN
cord-316534-ep7ezoko	20	21	spread	spread	VBN
cord-316534-ep7ezoko	20	22	worldwide	worldwide	RB
cord-316534-ep7ezoko	20	23	.	.	.
cord-316534-ep7ezoko	21	1	Every	every	DT
cord-316534-ep7ezoko	21	2	day	day	NN
cord-316534-ep7ezoko	21	3	,	,	,
cord-316534-ep7ezoko	21	4	7500	7500	CD
cord-316534-ep7ezoko	21	5	patients	patient	NNS
cord-316534-ep7ezoko	21	6	worldwide	worldwide	RB
cord-316534-ep7ezoko	21	7	are	be	VBP
cord-316534-ep7ezoko	21	8	infected	infect	VBN
cord-316534-ep7ezoko	21	9	with	with	IN
cord-316534-ep7ezoko	21	10	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	21	11	.	.	.
cord-316534-ep7ezoko	22	1	1	1	LS
cord-316534-ep7ezoko	22	2	Production	production	NN
cord-316534-ep7ezoko	22	3	of	of	IN
cord-316534-ep7ezoko	22	4	a	a	DT
cord-316534-ep7ezoko	22	5	vaccine	vaccine	NN
cord-316534-ep7ezoko	22	6	that	that	WDT
cord-316534-ep7ezoko	22	7	could	could	MD
cord-316534-ep7ezoko	22	8	inhibit	inhibit	VB
cord-316534-ep7ezoko	22	9	infection	infection	NN
cord-316534-ep7ezoko	22	10	,	,	,
cord-316534-ep7ezoko	22	11	reduce	reduce	VB
cord-316534-ep7ezoko	22	12	spread	spread	NN
cord-316534-ep7ezoko	22	13	,	,	,
cord-316534-ep7ezoko	22	14	or	or	CC
cord-316534-ep7ezoko	22	15	both	both	DT
cord-316534-ep7ezoko	22	16	would	would	MD
cord-316534-ep7ezoko	22	17	aid	aid	VB
cord-316534-ep7ezoko	22	18	in	in	IN
cord-316534-ep7ezoko	22	19	the	the	DT
cord-316534-ep7ezoko	22	20	reduction	reduction	NN
cord-316534-ep7ezoko	22	21	of	of	IN
cord-316534-ep7ezoko	22	22	the	the	DT
cord-316534-ep7ezoko	22	23	burden	burden	NN
cord-316534-ep7ezoko	22	24	of	of	IN
cord-316534-ep7ezoko	22	25	AIDS	AIDS	NNP
cord-316534-ep7ezoko	22	26	and	and	CC
cord-316534-ep7ezoko	22	27	AIDS	AIDS	NNP
cord-316534-ep7ezoko	22	28	-	-	HYPH
cord-316534-ep7ezoko	22	29	related	relate	VBN
cord-316534-ep7ezoko	22	30	diseases	disease	NNS
cord-316534-ep7ezoko	22	31	.	.	.
cord-316534-ep7ezoko	23	1	The	the	DT
cord-316534-ep7ezoko	23	2	expenses	expense	NNS
cord-316534-ep7ezoko	23	3	incurred	incur	VBN
cord-316534-ep7ezoko	23	4	by	by	IN
cord-316534-ep7ezoko	23	5	the	the	DT
cord-316534-ep7ezoko	23	6	AIDS	AIDS	NNP
cord-316534-ep7ezoko	23	7	epidemic	epidemic	NN
cord-316534-ep7ezoko	23	8	can	can	MD
cord-316534-ep7ezoko	23	9	hardly	hardly	RB
cord-316534-ep7ezoko	23	10	be	be	VB
cord-316534-ep7ezoko	23	11	calculated	calculate	VBN
cord-316534-ep7ezoko	23	12	.	.	.
cord-316534-ep7ezoko	24	1	They	-PRON-	PRP
cord-316534-ep7ezoko	24	2	range	range	VBP
cord-316534-ep7ezoko	24	3	from	from	IN
cord-316534-ep7ezoko	24	4	tens	ten	NNS
cord-316534-ep7ezoko	24	5	of	of	IN
cord-316534-ep7ezoko	24	6	thousands	thousand	NNS
cord-316534-ep7ezoko	24	7	of	of	IN
cord-316534-ep7ezoko	24	8	dollars	dollar	NNS
cord-316534-ep7ezoko	24	9	per	per	IN
cord-316534-ep7ezoko	24	10	patient	patient	NN
cord-316534-ep7ezoko	24	11	for	for	IN
cord-316534-ep7ezoko	24	12	the	the	DT
cord-316534-ep7ezoko	24	13	HAART	HAART	NNP
cord-316534-ep7ezoko	24	14	regimen	regimen	NN
cord-316534-ep7ezoko	24	15	,	,	,
cord-316534-ep7ezoko	24	16	to	to	IN
cord-316534-ep7ezoko	24	17	millions	million	NNS
cord-316534-ep7ezoko	24	18	of	of	IN
cord-316534-ep7ezoko	24	19	dollars	dollar	NNS
cord-316534-ep7ezoko	24	20	required	require	VBN
cord-316534-ep7ezoko	24	21	for	for	IN
cord-316534-ep7ezoko	24	22	building	building	NN
cord-316534-ep7ezoko	24	23	of	of	IN
cord-316534-ep7ezoko	24	24	orphanages	orphanage	NNS
cord-316534-ep7ezoko	24	25	by	by	IN
cord-316534-ep7ezoko	24	26	governments	government	NNS
cord-316534-ep7ezoko	24	27	for	for	IN
cord-316534-ep7ezoko	24	28	children	child	NNS
cord-316534-ep7ezoko	24	29	whose	whose	WP$
cord-316534-ep7ezoko	24	30	parents	parent	NNS
cord-316534-ep7ezoko	24	31	have	have	VBP
cord-316534-ep7ezoko	24	32	succumbed	succumb	VBN
cord-316534-ep7ezoko	24	33	to	to	IN
cord-316534-ep7ezoko	24	34	the	the	DT
cord-316534-ep7ezoko	24	35	disease	disease	NN
cord-316534-ep7ezoko	24	36	,	,	,
cord-316534-ep7ezoko	24	37	to	to	IN
cord-316534-ep7ezoko	24	38	the	the	DT
cord-316534-ep7ezoko	24	39	unknown	unknown	JJ
cord-316534-ep7ezoko	24	40	cost	cost	NN
cord-316534-ep7ezoko	24	41	of	of	IN
cord-316534-ep7ezoko	24	42	educational	educational	JJ
cord-316534-ep7ezoko	24	43	materials	material	NNS
cord-316534-ep7ezoko	24	44	and	and	CC
cord-316534-ep7ezoko	24	45	condoms	condom	NNS
cord-316534-ep7ezoko	24	46	in	in	IN
cord-316534-ep7ezoko	24	47	the	the	DT
cord-316534-ep7ezoko	24	48	effort	effort	NN
cord-316534-ep7ezoko	24	49	to	to	TO
cord-316534-ep7ezoko	24	50	prevent	prevent	VB
cord-316534-ep7ezoko	24	51	further	further	JJ
cord-316534-ep7ezoko	24	52	spread	spread	NN
cord-316534-ep7ezoko	24	53	of	of	IN
cord-316534-ep7ezoko	24	54	the	the	DT
cord-316534-ep7ezoko	24	55	disease	disease	NN
cord-316534-ep7ezoko	24	56	.	.	.
cord-316534-ep7ezoko	25	1	This	this	DT
cord-316534-ep7ezoko	25	2	public	public	JJ
cord-316534-ep7ezoko	25	3	health	health	NN
cord-316534-ep7ezoko	25	4	challenge	challenge	NN
cord-316534-ep7ezoko	25	5	has	have	VBZ
cord-316534-ep7ezoko	25	6	not	not	RB
cord-316534-ep7ezoko	25	7	gone	go	VBN
cord-316534-ep7ezoko	25	8	unnoticed	unnoticed	JJ
cord-316534-ep7ezoko	25	9	and	and	CC
cord-316534-ep7ezoko	25	10	has	have	VBZ
cord-316534-ep7ezoko	25	11	been	be	VBN
cord-316534-ep7ezoko	25	12	addressed	address	VBN
cord-316534-ep7ezoko	25	13	by	by	IN
cord-316534-ep7ezoko	25	14	scientists	scientist	NNS
cord-316534-ep7ezoko	25	15	'	'	POS
cord-316534-ep7ezoko	25	16	ongoing	ongoing	JJ
cord-316534-ep7ezoko	25	17	efforts	effort	NNS
cord-316534-ep7ezoko	25	18	to	to	TO
cord-316534-ep7ezoko	25	19	develop	develop	VB
cord-316534-ep7ezoko	25	20	a	a	DT
cord-316534-ep7ezoko	25	21	safe	safe	JJ
cord-316534-ep7ezoko	25	22	and	and	CC
cord-316534-ep7ezoko	25	23	effective	effective	JJ
cord-316534-ep7ezoko	25	24	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	25	25	vaccine	vaccine	NN
cord-316534-ep7ezoko	25	26	.	.	.
cord-316534-ep7ezoko	26	1	A	a	DT
cord-316534-ep7ezoko	26	2	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	26	3	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	26	4	vaccine	vaccine	NN
cord-316534-ep7ezoko	26	5	would	would	MD
cord-316534-ep7ezoko	26	6	offer	offer	VB
cord-316534-ep7ezoko	26	7	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	26	8	immunity	immunity	NN
cord-316534-ep7ezoko	26	9	to	to	IN
cord-316534-ep7ezoko	26	10	patients	patient	NNS
cord-316534-ep7ezoko	26	11	,	,	,
cord-316534-ep7ezoko	26	12	preventing	prevent	VBG
cord-316534-ep7ezoko	26	13	infection	infection	NN
cord-316534-ep7ezoko	26	14	upon	upon	IN
cord-316534-ep7ezoko	26	15	presentation	presentation	NN
cord-316534-ep7ezoko	26	16	of	of	IN
cord-316534-ep7ezoko	26	17	the	the	DT
cord-316534-ep7ezoko	26	18	virus	virus	NN
cord-316534-ep7ezoko	26	19	.	.	.
cord-316534-ep7ezoko	27	1	A	a	DT
cord-316534-ep7ezoko	27	2	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	27	3	vaccine	vaccine	NN
cord-316534-ep7ezoko	27	4	must	must	MD
cord-316534-ep7ezoko	27	5	also	also	RB
cord-316534-ep7ezoko	27	6	be	be	VB
cord-316534-ep7ezoko	27	7	effective	effective	JJ
cord-316534-ep7ezoko	27	8	at	at	IN
cord-316534-ep7ezoko	27	9	all	all	DT
cord-316534-ep7ezoko	27	10	possible	possible	JJ
cord-316534-ep7ezoko	27	11	portals	portal	NNS
cord-316534-ep7ezoko	27	12	of	of	IN
cord-316534-ep7ezoko	27	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	27	14	entry	entry	NN
cord-316534-ep7ezoko	27	15	,	,	,
cord-316534-ep7ezoko	27	16	especially	especially	RB
cord-316534-ep7ezoko	27	17	the	the	DT
cord-316534-ep7ezoko	27	18	mucosa	mucosa	NN
cord-316534-ep7ezoko	27	19	.	.	.
cord-316534-ep7ezoko	28	1	7	7	CD
cord-316534-ep7ezoko	29	1	For	for	IN
cord-316534-ep7ezoko	29	2	this	this	DT
cord-316534-ep7ezoko	29	3	to	to	TO
cord-316534-ep7ezoko	29	4	occur	occur	VB
cord-316534-ep7ezoko	29	5	,	,	,
cord-316534-ep7ezoko	29	6	the	the	DT
cord-316534-ep7ezoko	29	7	vaccine	vaccine	NN
cord-316534-ep7ezoko	29	8	must	must	MD
cord-316534-ep7ezoko	29	9	offer	offer	VB
cord-316534-ep7ezoko	29	10	broad	broad	JJ
cord-316534-ep7ezoko	29	11	and	and	CC
cord-316534-ep7ezoko	29	12	durable	durable	JJ
cord-316534-ep7ezoko	29	13	immunity	immunity	NN
cord-316534-ep7ezoko	29	14	.	.	.
cord-316534-ep7ezoko	30	1	Several	several	JJ
cord-316534-ep7ezoko	30	2	consortia	consortium	NNS
cord-316534-ep7ezoko	30	3	have	have	VBP
cord-316534-ep7ezoko	30	4	worked	work	VBN
cord-316534-ep7ezoko	30	5	diligently	diligently	RB
cord-316534-ep7ezoko	30	6	to	to	TO
cord-316534-ep7ezoko	30	7	produce	produce	VB
cord-316534-ep7ezoko	30	8	a	a	DT
cord-316534-ep7ezoko	30	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	30	10	that	that	WDT
cord-316534-ep7ezoko	30	11	will	will	MD
cord-316534-ep7ezoko	30	12	induce	induce	VB
cord-316534-ep7ezoko	30	13	broadly	broadly	RB
cord-316534-ep7ezoko	30	14	reactive	reactive	JJ
cord-316534-ep7ezoko	30	15	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	30	16	antibodies	antibody	NNS
cord-316534-ep7ezoko	30	17	(	(	-LRB-
cord-316534-ep7ezoko	30	18	Nabs	Nabs	NNP
cord-316534-ep7ezoko	30	19	)	)	-RRB-
cord-316534-ep7ezoko	30	20	.	.	.
cord-316534-ep7ezoko	31	1	These	these	DT
cord-316534-ep7ezoko	31	2	consortia	consortium	NNS
cord-316534-ep7ezoko	31	3	include	include	VBP
cord-316534-ep7ezoko	31	4	major	major	JJ
cord-316534-ep7ezoko	31	5	international	international	JJ
cord-316534-ep7ezoko	31	6	efforts	effort	NNS
cord-316534-ep7ezoko	31	7	as	as	RB
cord-316534-ep7ezoko	31	8	well	well	RB
cord-316534-ep7ezoko	31	9	as	as	IN
cord-316534-ep7ezoko	31	10	efforts	effort	NNS
cord-316534-ep7ezoko	31	11	of	of	IN
cord-316534-ep7ezoko	31	12	individual	individual	JJ
cord-316534-ep7ezoko	31	13	countries	country	NNS
cord-316534-ep7ezoko	31	14	,	,	,
cord-316534-ep7ezoko	31	15	regions	region	NNS
cord-316534-ep7ezoko	31	16	,	,	,
cord-316534-ep7ezoko	31	17	and	and	CC
cord-316534-ep7ezoko	31	18	institutions	institution	NNS
cord-316534-ep7ezoko	31	19	including	include	VBG
cord-316534-ep7ezoko	31	20	,	,	,
cord-316534-ep7ezoko	31	21	but	but	CC
cord-316534-ep7ezoko	31	22	not	not	RB
cord-316534-ep7ezoko	31	23	limited	limited	JJ
cord-316534-ep7ezoko	31	24	to	to	IN
cord-316534-ep7ezoko	31	25	:	:	:
cord-316534-ep7ezoko	31	26	the	the	DT
cord-316534-ep7ezoko	31	27	International	International	NNP
cord-316534-ep7ezoko	31	28	AIDS	AIDS	NNP
cord-316534-ep7ezoko	31	29	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	31	30	Initiative	Initiative	NNP
cord-316534-ep7ezoko	31	31	Neutralizing	Neutralizing	NNP
cord-316534-ep7ezoko	31	32	Antibody	Antibody	NNP
cord-316534-ep7ezoko	31	33	Consortium	Consortium	NNP
cord-316534-ep7ezoko	31	34	,	,	,
cord-316534-ep7ezoko	31	35	8	8	CD
cord-316534-ep7ezoko	31	36	the	the	DT
cord-316534-ep7ezoko	31	37	Center	Center	NNP
cord-316534-ep7ezoko	31	38	for	for	IN
cord-316534-ep7ezoko	31	39	HIV	HIV	NNP
cord-316534-ep7ezoko	31	40	-	-	HYPH
cord-316534-ep7ezoko	31	41	AIDS	AIDS	NNP
cord-316534-ep7ezoko	31	42	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	31	43	Immunology	Immunology	NNP
cord-316534-ep7ezoko	31	44	,	,	,
cord-316534-ep7ezoko	31	45	the	the	DT
cord-316534-ep7ezoko	31	46	HIV	HIV	NNP
cord-316534-ep7ezoko	31	47	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	31	48	Trials	Trials	NNP
cord-316534-ep7ezoko	31	49	Network	Network	NNP
cord-316534-ep7ezoko	31	50	,	,	,
cord-316534-ep7ezoko	31	51	US	US	NNP
cord-316534-ep7ezoko	31	52	Military	military	JJ
cord-316534-ep7ezoko	31	53	HIV	HIV	NNP
cord-316534-ep7ezoko	31	54	Research	Research	NNP
cord-316534-ep7ezoko	31	55	Program	Program	NNP
cord-316534-ep7ezoko	31	56	,	,	,
cord-316534-ep7ezoko	31	57	the	the	DT
cord-316534-ep7ezoko	31	58	Collaboration	Collaboration	NNP
cord-316534-ep7ezoko	31	59	for	for	IN
cord-316534-ep7ezoko	31	60	AIDS	AIDS	NNP
cord-316534-ep7ezoko	31	61	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	31	62	Discovery	Discovery	NNP
cord-316534-ep7ezoko	31	63	,	,	,
cord-316534-ep7ezoko	31	64	and	and	CC
cord-316534-ep7ezoko	31	65	the	the	DT
cord-316534-ep7ezoko	31	66	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	31	67	Research	Research	NNP
cord-316534-ep7ezoko	31	68	Center	Center	NNP
cord-316534-ep7ezoko	31	69	at	at	IN
cord-316534-ep7ezoko	31	70	the	the	DT
cord-316534-ep7ezoko	31	71	National	National	NNP
cord-316534-ep7ezoko	31	72	Institutes	Institutes	NNPS
cord-316534-ep7ezoko	31	73	of	of	IN
cord-316534-ep7ezoko	31	74	Allergy	Allergy	NNP
cord-316534-ep7ezoko	31	75	and	and	CC
cord-316534-ep7ezoko	31	76	Infectious	Infectious	NNP
cord-316534-ep7ezoko	31	77	Diseases	Diseases	NNPS
cord-316534-ep7ezoko	31	78	of	of	IN
cord-316534-ep7ezoko	31	79	the	the	DT
cord-316534-ep7ezoko	31	80	National	National	NNP
cord-316534-ep7ezoko	31	81	Institutes	Institutes	NNPS
cord-316534-ep7ezoko	31	82	of	of	IN
cord-316534-ep7ezoko	31	83	Health	Health	NNP
cord-316534-ep7ezoko	31	84	.	.	.
cord-316534-ep7ezoko	32	1	To	to	IN
cord-316534-ep7ezoko	32	2	date	date	NN
cord-316534-ep7ezoko	32	3	,	,	,
cord-316534-ep7ezoko	32	4	however	however	RB
cord-316534-ep7ezoko	32	5	,	,	,
cord-316534-ep7ezoko	32	6	no	no	DT
cord-316534-ep7ezoko	32	7	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	32	8	candidate	candidate	NN
cord-316534-ep7ezoko	32	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	32	10	has	have	VBZ
cord-316534-ep7ezoko	32	11	induced	induce	VBN
cord-316534-ep7ezoko	32	12	broadly	broadly	RB
cord-316534-ep7ezoko	32	13	reactive	reactive	JJ
cord-316534-ep7ezoko	32	14	Nabs	Nabs	NNP
cord-316534-ep7ezoko	32	15	.	.	.
cord-316534-ep7ezoko	33	1	8	8	CD
cord-316534-ep7ezoko	34	1	In	in	IN
cord-316534-ep7ezoko	34	2	the	the	DT
cord-316534-ep7ezoko	34	3	absence	absence	NN
cord-316534-ep7ezoko	34	4	of	of	IN
cord-316534-ep7ezoko	34	5	a	a	DT
cord-316534-ep7ezoko	34	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	34	7	that	that	WDT
cord-316534-ep7ezoko	34	8	can	can	MD
cord-316534-ep7ezoko	34	9	prevent	prevent	VB
cord-316534-ep7ezoko	34	10	infection	infection	NN
cord-316534-ep7ezoko	34	11	of	of	IN
cord-316534-ep7ezoko	34	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	34	13	,	,	,
cord-316534-ep7ezoko	34	14	there	there	EX
cord-316534-ep7ezoko	34	15	are	be	VBP
cord-316534-ep7ezoko	34	16	still	still	RB
cord-316534-ep7ezoko	34	17	many	many	JJ
cord-316534-ep7ezoko	34	18	benefits	benefit	NNS
cord-316534-ep7ezoko	34	19	to	to	TO
cord-316534-ep7ezoko	34	20	be	be	VB
cord-316534-ep7ezoko	34	21	realized	realize	VBN
cord-316534-ep7ezoko	34	22	from	from	IN
cord-316534-ep7ezoko	34	23	production	production	NN
cord-316534-ep7ezoko	34	24	of	of	IN
cord-316534-ep7ezoko	34	25	a	a	DT
cord-316534-ep7ezoko	34	26	therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	34	27	vaccine	vaccine	NN
cord-316534-ep7ezoko	34	28	.	.	.
cord-316534-ep7ezoko	35	1	A	a	DT
cord-316534-ep7ezoko	35	2	therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	35	3	vaccine	vaccine	NN
cord-316534-ep7ezoko	35	4	would	would	MD
cord-316534-ep7ezoko	35	5	be	be	VB
cord-316534-ep7ezoko	35	6	supremely	supremely	RB
cord-316534-ep7ezoko	35	7	valuable	valuable	JJ
cord-316534-ep7ezoko	35	8	if	if	IN
cord-316534-ep7ezoko	35	9	it	-PRON-	PRP
cord-316534-ep7ezoko	35	10	were	be	VBD
cord-316534-ep7ezoko	35	11	able	able	JJ
cord-316534-ep7ezoko	35	12	to	to	TO
cord-316534-ep7ezoko	35	13	increase	increase	VB
cord-316534-ep7ezoko	35	14	the	the	DT
cord-316534-ep7ezoko	35	15	titer	titer	NN
cord-316534-ep7ezoko	35	16	of	of	IN
cord-316534-ep7ezoko	35	17	virus	virus	NN
cord-316534-ep7ezoko	35	18	necessary	necessary	JJ
cord-316534-ep7ezoko	35	19	for	for	IN
cord-316534-ep7ezoko	35	20	infection	infection	NN
cord-316534-ep7ezoko	35	21	,	,	,
cord-316534-ep7ezoko	35	22	increase	increase	VB
cord-316534-ep7ezoko	35	23	the	the	DT
cord-316534-ep7ezoko	35	24	time	time	NN
cord-316534-ep7ezoko	35	25	to	to	IN
cord-316534-ep7ezoko	35	26	clinical	clinical	JJ
cord-316534-ep7ezoko	35	27	manifestation	manifestation	NN
cord-316534-ep7ezoko	35	28	of	of	IN
cord-316534-ep7ezoko	35	29	virus	virus	NN
cord-316534-ep7ezoko	35	30	,	,	,
cord-316534-ep7ezoko	35	31	control	control	VB
cord-316534-ep7ezoko	35	32	viral	viral	JJ
cord-316534-ep7ezoko	35	33	load	load	NN
cord-316534-ep7ezoko	35	34	after	after	IN
cord-316534-ep7ezoko	35	35	infection	infection	NN
cord-316534-ep7ezoko	35	36	,	,	,
cord-316534-ep7ezoko	35	37	and	and	CC
cord-316534-ep7ezoko	35	38	reduce	reduce	VB
cord-316534-ep7ezoko	35	39	secondary	secondary	JJ
cord-316534-ep7ezoko	35	40	transmission	transmission	NN
cord-316534-ep7ezoko	35	41	.	.	.
cord-316534-ep7ezoko	36	1	[	[	-LRB-
cord-316534-ep7ezoko	36	2	9	9	CD
cord-316534-ep7ezoko	36	3	]	]	-RRB-
cord-316534-ep7ezoko	36	4	[	[	-LRB-
cord-316534-ep7ezoko	36	5	10	10	CD
cord-316534-ep7ezoko	36	6	]	]	-RRB-
cord-316534-ep7ezoko	36	7	[	[	-LRB-
cord-316534-ep7ezoko	36	8	11	11	CD
cord-316534-ep7ezoko	36	9	]	]	-RRB-
cord-316534-ep7ezoko	36	10	[	[	-LRB-
cord-316534-ep7ezoko	36	11	12	12	CD
cord-316534-ep7ezoko	36	12	]	]	-RRB-
cord-316534-ep7ezoko	36	13	[	[	-LRB-
cord-316534-ep7ezoko	36	14	13	13	CD
cord-316534-ep7ezoko	36	15	]	]	-RRB-
cord-316534-ep7ezoko	37	1	A	a	DT
cord-316534-ep7ezoko	37	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	37	3	that	that	WDT
cord-316534-ep7ezoko	37	4	could	could	MD
cord-316534-ep7ezoko	37	5	induce	induce	VB
cord-316534-ep7ezoko	37	6	this	this	DT
cord-316534-ep7ezoko	37	7	type	type	NN
cord-316534-ep7ezoko	37	8	of	of	IN
cord-316534-ep7ezoko	37	9	response	response	NN
cord-316534-ep7ezoko	37	10	would	would	MD
cord-316534-ep7ezoko	37	11	invariably	invariably	RB
cord-316534-ep7ezoko	37	12	decrease	decrease	VB
cord-316534-ep7ezoko	37	13	contagiousness	contagiousness	NN
cord-316534-ep7ezoko	37	14	,	,	,
cord-316534-ep7ezoko	37	15	decrease	decrease	VB
cord-316534-ep7ezoko	37	16	the	the	DT
cord-316534-ep7ezoko	37	17	need	need	NN
cord-316534-ep7ezoko	37	18	for	for	IN
cord-316534-ep7ezoko	37	19	costly	costly	JJ
cord-316534-ep7ezoko	37	20	and	and	CC
cord-316534-ep7ezoko	37	21	potentially	potentially	RB
cord-316534-ep7ezoko	37	22	dangerous	dangerous	JJ
cord-316534-ep7ezoko	37	23	ART	art	NN
cord-316534-ep7ezoko	37	24	/	/	SYM
cord-316534-ep7ezoko	37	25	HAART	HAART	NNP
cord-316534-ep7ezoko	37	26	,	,	,
cord-316534-ep7ezoko	37	27	and	and	CC
cord-316534-ep7ezoko	37	28	decrease	decrease	VB
cord-316534-ep7ezoko	37	29	the	the	DT
cord-316534-ep7ezoko	37	30	number	number	NN
cord-316534-ep7ezoko	37	31	of	of	IN
cord-316534-ep7ezoko	37	32	opportunistic	opportunistic	JJ
cord-316534-ep7ezoko	37	33	infections	infection	NNS
cord-316534-ep7ezoko	37	34	of	of	IN
cord-316534-ep7ezoko	37	35	patients	patient	NNS
cord-316534-ep7ezoko	37	36	.	.	.
cord-316534-ep7ezoko	38	1	While	while	IN
cord-316534-ep7ezoko	38	2	the	the	DT
cord-316534-ep7ezoko	38	3	effect	effect	NN
cord-316534-ep7ezoko	38	4	of	of	IN
cord-316534-ep7ezoko	38	5	controlling	control	VBG
cord-316534-ep7ezoko	38	6	the	the	DT
cord-316534-ep7ezoko	38	7	normal	normal	JJ
cord-316534-ep7ezoko	38	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	38	9	pathology	pathology	NN
cord-316534-ep7ezoko	38	10	with	with	IN
cord-316534-ep7ezoko	38	11	therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	38	12	vaccines	vaccine	NNS
cord-316534-ep7ezoko	38	13	will	will	MD
cord-316534-ep7ezoko	38	14	be	be	VB
cord-316534-ep7ezoko	38	15	favorable	favorable	JJ
cord-316534-ep7ezoko	38	16	for	for	IN
cord-316534-ep7ezoko	38	17	the	the	DT
cord-316534-ep7ezoko	38	18	individual	individual	JJ
cord-316534-ep7ezoko	38	19	patient	patient	NN
cord-316534-ep7ezoko	38	20	as	as	RB
cord-316534-ep7ezoko	38	21	well	well	RB
cord-316534-ep7ezoko	38	22	as	as	IN
cord-316534-ep7ezoko	38	23	society	society	NN
cord-316534-ep7ezoko	38	24	,	,	,
cord-316534-ep7ezoko	38	25	the	the	DT
cord-316534-ep7ezoko	38	26	effect	effect	NN
cord-316534-ep7ezoko	38	27	of	of	IN
cord-316534-ep7ezoko	38	28	preventing	prevent	VBG
cord-316534-ep7ezoko	38	29	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	38	30	infections	infection	NNS
cord-316534-ep7ezoko	38	31	in	in	IN
cord-316534-ep7ezoko	38	32	humans	human	NNS
cord-316534-ep7ezoko	38	33	with	with	IN
cord-316534-ep7ezoko	38	34	a	a	DT
cord-316534-ep7ezoko	38	35	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	38	36	vaccine	vaccine	NN
cord-316534-ep7ezoko	38	37	is	be	VBZ
cord-316534-ep7ezoko	38	38	also	also	RB
cord-316534-ep7ezoko	38	39	broadly	broadly	RB
cord-316534-ep7ezoko	38	40	appealing	appealing	JJ
cord-316534-ep7ezoko	38	41	.	.	.
cord-316534-ep7ezoko	39	1	This	this	DT
cord-316534-ep7ezoko	39	2	potential	potential	NN
cord-316534-ep7ezoko	39	3	for	for	IN
cord-316534-ep7ezoko	39	4	eradicating	eradicate	VBG
cord-316534-ep7ezoko	39	5	the	the	DT
cord-316534-ep7ezoko	39	6	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	39	7	virus	virus	NN
cord-316534-ep7ezoko	39	8	from	from	IN
cord-316534-ep7ezoko	39	9	human	human	JJ
cord-316534-ep7ezoko	39	10	hosts	host	NNS
cord-316534-ep7ezoko	39	11	drives	drive	VBZ
cord-316534-ep7ezoko	39	12	scientists	scientist	NNS
cord-316534-ep7ezoko	39	13	to	to	TO
cord-316534-ep7ezoko	39	14	continue	continue	VB
cord-316534-ep7ezoko	39	15	to	to	TO
cord-316534-ep7ezoko	39	16	find	find	VB
cord-316534-ep7ezoko	39	17	ways	way	NNS
cord-316534-ep7ezoko	39	18	to	to	TO
cord-316534-ep7ezoko	39	19	circumvent	circumvent	VB
cord-316534-ep7ezoko	39	20	the	the	DT
cord-316534-ep7ezoko	39	21	challenges	challenge	NNS
cord-316534-ep7ezoko	39	22	presented	present	VBN
cord-316534-ep7ezoko	39	23	by	by	IN
cord-316534-ep7ezoko	39	24	this	this	DT
cord-316534-ep7ezoko	39	25	unique	unique	JJ
cord-316534-ep7ezoko	39	26	virus	virus	NN
cord-316534-ep7ezoko	39	27	in	in	IN
cord-316534-ep7ezoko	39	28	order	order	NN
cord-316534-ep7ezoko	39	29	to	to	TO
cord-316534-ep7ezoko	39	30	induce	induce	VB
cord-316534-ep7ezoko	39	31	production	production	NN
cord-316534-ep7ezoko	39	32	of	of	IN
cord-316534-ep7ezoko	39	33	the	the	DT
cord-316534-ep7ezoko	39	34	Nabs	Nabs	NNP
cord-316534-ep7ezoko	39	35	that	that	WDT
cord-316534-ep7ezoko	39	36	are	be	VBP
cord-316534-ep7ezoko	39	37	critical	critical	JJ
cord-316534-ep7ezoko	39	38	for	for	IN
cord-316534-ep7ezoko	39	39	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	39	40	immunity	immunity	NN
cord-316534-ep7ezoko	39	41	.	.	.
cord-316534-ep7ezoko	40	1	This	this	DT
cord-316534-ep7ezoko	40	2	review	review	NN
cord-316534-ep7ezoko	40	3	,	,	,
cord-316534-ep7ezoko	40	4	therefore	therefore	RB
cord-316534-ep7ezoko	40	5	,	,	,
cord-316534-ep7ezoko	40	6	will	will	MD
cord-316534-ep7ezoko	40	7	focus	focus	VB
cord-316534-ep7ezoko	40	8	on	on	IN
cord-316534-ep7ezoko	40	9	the	the	DT
cord-316534-ep7ezoko	40	10	specific	specific	JJ
cord-316534-ep7ezoko	40	11	challenges	challenge	NNS
cord-316534-ep7ezoko	40	12	presented	present	VBN
cord-316534-ep7ezoko	40	13	by	by	IN
cord-316534-ep7ezoko	40	14	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	40	15	and	and	CC
cord-316534-ep7ezoko	40	16	strides	stride	NNS
cord-316534-ep7ezoko	40	17	that	that	WDT
cord-316534-ep7ezoko	40	18	have	have	VBP
cord-316534-ep7ezoko	40	19	been	be	VBN
cord-316534-ep7ezoko	40	20	made	make	VBN
cord-316534-ep7ezoko	40	21	toward	toward	IN
cord-316534-ep7ezoko	40	22	creating	create	VBG
cord-316534-ep7ezoko	40	23	a	a	DT
cord-316534-ep7ezoko	40	24	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	40	25	vaccine	vaccine	NN
cord-316534-ep7ezoko	40	26	,	,	,
cord-316534-ep7ezoko	40	27	including	include	VBG
cord-316534-ep7ezoko	40	28	past	past	JJ
cord-316534-ep7ezoko	40	29	efforts	effort	NNS
cord-316534-ep7ezoko	40	30	that	that	WDT
cord-316534-ep7ezoko	40	31	have	have	VBP
cord-316534-ep7ezoko	40	32	failed	fail	VBN
cord-316534-ep7ezoko	40	33	and	and	CC
cord-316534-ep7ezoko	40	34	lessons	lesson	NNS
cord-316534-ep7ezoko	40	35	that	that	WDT
cord-316534-ep7ezoko	40	36	have	have	VBP
cord-316534-ep7ezoko	40	37	been	be	VBN
cord-316534-ep7ezoko	40	38	learned	learn	VBN
cord-316534-ep7ezoko	40	39	from	from	IN
cord-316534-ep7ezoko	40	40	those	those	DT
cord-316534-ep7ezoko	40	41	failures	failure	NNS
cord-316534-ep7ezoko	40	42	.	.	.
cord-316534-ep7ezoko	41	1	We	-PRON-	PRP
cord-316534-ep7ezoko	41	2	will	will	MD
cord-316534-ep7ezoko	41	3	also	also	RB
cord-316534-ep7ezoko	41	4	discuss	discuss	VB
cord-316534-ep7ezoko	41	5	novel	novel	JJ
cord-316534-ep7ezoko	41	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	41	7	options	option	NNS
cord-316534-ep7ezoko	41	8	and	and	CC
cord-316534-ep7ezoko	41	9	some	some	DT
cord-316534-ep7ezoko	41	10	of	of	IN
cord-316534-ep7ezoko	41	11	the	the	DT
cord-316534-ep7ezoko	41	12	promising	promising	JJ
cord-316534-ep7ezoko	41	13	trials	trial	NNS
cord-316534-ep7ezoko	41	14	that	that	WDT
cord-316534-ep7ezoko	41	15	are	be	VBP
cord-316534-ep7ezoko	41	16	currently	currently	RB
cord-316534-ep7ezoko	41	17	underway	underway	JJ
cord-316534-ep7ezoko	41	18	.	.	.
cord-316534-ep7ezoko	42	1	While	while	IN
cord-316534-ep7ezoko	42	2	several	several	JJ
cord-316534-ep7ezoko	42	3	problems	problem	NNS
cord-316534-ep7ezoko	42	4	face	face	VBP
cord-316534-ep7ezoko	42	5	scientists	scientist	NNS
cord-316534-ep7ezoko	42	6	who	who	WP
cord-316534-ep7ezoko	42	7	are	be	VBP
cord-316534-ep7ezoko	42	8	attempting	attempt	VBG
cord-316534-ep7ezoko	42	9	to	to	TO
cord-316534-ep7ezoko	42	10	create	create	VB
cord-316534-ep7ezoko	42	11	an	an	DT
cord-316534-ep7ezoko	42	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	42	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	42	14	,	,	,
cord-316534-ep7ezoko	42	15	three	three	CD
cord-316534-ep7ezoko	42	16	problems	problem	NNS
cord-316534-ep7ezoko	42	17	in	in	IN
cord-316534-ep7ezoko	42	18	particular	particular	JJ
cord-316534-ep7ezoko	42	19	have	have	VBP
cord-316534-ep7ezoko	42	20	posed	pose	VBN
cord-316534-ep7ezoko	42	21	extremely	extremely	RB
cord-316534-ep7ezoko	42	22	daunting	daunting	JJ
cord-316534-ep7ezoko	42	23	challenges	challenge	NNS
cord-316534-ep7ezoko	42	24	.	.	.
cord-316534-ep7ezoko	43	1	These	these	DT
cord-316534-ep7ezoko	43	2	three	three	CD
cord-316534-ep7ezoko	43	3	problems	problem	NNS
cord-316534-ep7ezoko	43	4	are	be	VBP
cord-316534-ep7ezoko	43	5	1	1	CD
cord-316534-ep7ezoko	43	6	)	)	-RRB-
cord-316534-ep7ezoko	43	7	degree	degree	NN
cord-316534-ep7ezoko	43	8	of	of	IN
cord-316534-ep7ezoko	43	9	diversity	diversity	NN
cord-316534-ep7ezoko	43	10	of	of	IN
cord-316534-ep7ezoko	43	11	the	the	DT
cord-316534-ep7ezoko	43	12	virus	virus	NN
cord-316534-ep7ezoko	43	13	,	,	,
cord-316534-ep7ezoko	43	14	2	2	LS
cord-316534-ep7ezoko	43	15	)	)	-RRB-
cord-316534-ep7ezoko	43	16	ability	ability	NN
cord-316534-ep7ezoko	43	17	of	of	IN
cord-316534-ep7ezoko	43	18	the	the	DT
cord-316534-ep7ezoko	43	19	virus	virus	NN
cord-316534-ep7ezoko	43	20	to	to	TO
cord-316534-ep7ezoko	43	21	evade	evade	VB
cord-316534-ep7ezoko	43	22	the	the	DT
cord-316534-ep7ezoko	43	23	hosts	host	NNS
cord-316534-ep7ezoko	43	24	'	'	POS
cord-316534-ep7ezoko	43	25	immunity	immunity	NN
cord-316534-ep7ezoko	43	26	,	,	,
cord-316534-ep7ezoko	43	27	and	and	CC
cord-316534-ep7ezoko	43	28	3	3	LS
cord-316534-ep7ezoko	43	29	)	)	-RRB-
cord-316534-ep7ezoko	43	30	lack	lack	NN
cord-316534-ep7ezoko	43	31	of	of	IN
cord-316534-ep7ezoko	43	32	appropriate	appropriate	JJ
cord-316534-ep7ezoko	43	33	animal	animal	NN
cord-316534-ep7ezoko	43	34	models	model	NNS
cord-316534-ep7ezoko	43	35	in	in	IN
cord-316534-ep7ezoko	43	36	which	which	WDT
cord-316534-ep7ezoko	43	37	to	to	TO
cord-316534-ep7ezoko	43	38	test	test	VB
cord-316534-ep7ezoko	43	39	vaccine	vaccine	NN
cord-316534-ep7ezoko	43	40	candidates	candidate	NNS
cord-316534-ep7ezoko	43	41	.	.	.
cord-316534-ep7ezoko	44	1	These	these	DT
cord-316534-ep7ezoko	44	2	three	three	CD
cord-316534-ep7ezoko	44	3	major	major	JJ
cord-316534-ep7ezoko	44	4	problems	problem	NNS
cord-316534-ep7ezoko	44	5	will	will	MD
cord-316534-ep7ezoko	44	6	be	be	VB
cord-316534-ep7ezoko	44	7	discussed	discuss	VBN
cord-316534-ep7ezoko	44	8	in	in	IN
cord-316534-ep7ezoko	44	9	more	more	JJR
cord-316534-ep7ezoko	44	10	detail	detail	NN
cord-316534-ep7ezoko	44	11	below	below	RB
cord-316534-ep7ezoko	44	12	.	.	.
cord-316534-ep7ezoko	45	1	Traditionally	traditionally	RB
cord-316534-ep7ezoko	45	2	,	,	,
cord-316534-ep7ezoko	45	3	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	45	4	vaccines	vaccine	NNS
cord-316534-ep7ezoko	45	5	have	have	VBP
cord-316534-ep7ezoko	45	6	been	be	VBN
cord-316534-ep7ezoko	45	7	made	make	VBN
cord-316534-ep7ezoko	45	8	by	by	IN
cord-316534-ep7ezoko	45	9	exposing	expose	VBG
cord-316534-ep7ezoko	45	10	some	some	DT
cord-316534-ep7ezoko	45	11	part	part	NN
cord-316534-ep7ezoko	45	12	of	of	IN
cord-316534-ep7ezoko	45	13	a	a	DT
cord-316534-ep7ezoko	45	14	pathogen	pathogen	NN
cord-316534-ep7ezoko	45	15	's	's	POS
cord-316534-ep7ezoko	45	16	structure	structure	NN
cord-316534-ep7ezoko	45	17	as	as	IN
cord-316534-ep7ezoko	45	18	an	an	DT
cord-316534-ep7ezoko	45	19	antigen	antigen	NN
cord-316534-ep7ezoko	45	20	to	to	IN
cord-316534-ep7ezoko	45	21	the	the	DT
cord-316534-ep7ezoko	45	22	host	host	NN
cord-316534-ep7ezoko	45	23	's	's	POS
cord-316534-ep7ezoko	45	24	immune	immune	JJ
cord-316534-ep7ezoko	45	25	system	system	NN
cord-316534-ep7ezoko	45	26	,	,	,
cord-316534-ep7ezoko	45	27	and	and	CC
cord-316534-ep7ezoko	45	28	eliciting	elicit	VBG
cord-316534-ep7ezoko	45	29	an	an	DT
cord-316534-ep7ezoko	45	30	immune	immune	JJ
cord-316534-ep7ezoko	45	31	response	response	NN
cord-316534-ep7ezoko	45	32	,	,	,
cord-316534-ep7ezoko	45	33	resulting	result	VBG
cord-316534-ep7ezoko	45	34	in	in	IN
cord-316534-ep7ezoko	45	35	the	the	DT
cord-316534-ep7ezoko	45	36	production	production	NN
cord-316534-ep7ezoko	45	37	of	of	IN
cord-316534-ep7ezoko	45	38	long	long	JJ
cord-316534-ep7ezoko	45	39	-	-	HYPH
cord-316534-ep7ezoko	45	40	term	term	NN
cord-316534-ep7ezoko	45	41	memory	memory	NN
cord-316534-ep7ezoko	45	42	lymphocytes	lymphocyte	NNS
cord-316534-ep7ezoko	45	43	that	that	WDT
cord-316534-ep7ezoko	45	44	are	be	VBP
cord-316534-ep7ezoko	45	45	capable	capable	JJ
cord-316534-ep7ezoko	45	46	of	of	IN
cord-316534-ep7ezoko	45	47	mounting	mount	VBG
cord-316534-ep7ezoko	45	48	a	a	DT
cord-316534-ep7ezoko	45	49	strong	strong	JJ
cord-316534-ep7ezoko	45	50	immune	immune	JJ
cord-316534-ep7ezoko	45	51	response	response	NN
cord-316534-ep7ezoko	45	52	upon	upon	IN
cord-316534-ep7ezoko	45	53	later	later	JJ
cord-316534-ep7ezoko	45	54	infection	infection	NN
cord-316534-ep7ezoko	45	55	with	with	IN
cord-316534-ep7ezoko	45	56	the	the	DT
cord-316534-ep7ezoko	45	57	pathogen	pathogen	NN
cord-316534-ep7ezoko	45	58	.	.	.
cord-316534-ep7ezoko	46	1	The	the	DT
cord-316534-ep7ezoko	46	2	premise	premise	NN
cord-316534-ep7ezoko	46	3	upon	upon	IN
cord-316534-ep7ezoko	46	4	which	which	WDT
cord-316534-ep7ezoko	46	5	this	this	DT
cord-316534-ep7ezoko	46	6	manipulation	manipulation	NN
cord-316534-ep7ezoko	46	7	of	of	IN
cord-316534-ep7ezoko	46	8	the	the	DT
cord-316534-ep7ezoko	46	9	immune	immune	JJ
cord-316534-ep7ezoko	46	10	system	system	NN
cord-316534-ep7ezoko	46	11	is	be	VBZ
cord-316534-ep7ezoko	46	12	based	base	VBN
cord-316534-ep7ezoko	46	13	is	be	VBZ
cord-316534-ep7ezoko	46	14	the	the	DT
cord-316534-ep7ezoko	46	15	ability	ability	NN
cord-316534-ep7ezoko	46	16	of	of	IN
cord-316534-ep7ezoko	46	17	the	the	DT
cord-316534-ep7ezoko	46	18	immune	immune	JJ
cord-316534-ep7ezoko	46	19	system	system	NN
cord-316534-ep7ezoko	46	20	to	to	TO
cord-316534-ep7ezoko	46	21	make	make	VB
cord-316534-ep7ezoko	46	22	long	long	RB
cord-316534-ep7ezoko	46	23	-	-	HYPH
cord-316534-ep7ezoko	46	24	lasting	last	VBG
cord-316534-ep7ezoko	46	25	antibodies	antibody	NNS
cord-316534-ep7ezoko	46	26	to	to	IN
cord-316534-ep7ezoko	46	27	conserved	conserved	JJ
cord-316534-ep7ezoko	46	28	structures	structure	NNS
cord-316534-ep7ezoko	46	29	on	on	IN
cord-316534-ep7ezoko	46	30	exposed	expose	VBN
cord-316534-ep7ezoko	46	31	proteins	protein	NNS
cord-316534-ep7ezoko	46	32	that	that	WDT
cord-316534-ep7ezoko	46	33	are	be	VBP
cord-316534-ep7ezoko	46	34	native	native	JJ
cord-316534-ep7ezoko	46	35	to	to	IN
cord-316534-ep7ezoko	46	36	the	the	DT
cord-316534-ep7ezoko	46	37	pathogen	pathogen	NN
cord-316534-ep7ezoko	46	38	.	.	.
cord-316534-ep7ezoko	47	1	Ideally	ideally	RB
cord-316534-ep7ezoko	47	2	,	,	,
cord-316534-ep7ezoko	47	3	both	both	CC
cord-316534-ep7ezoko	47	4	humoral	humoral	JJ
cord-316534-ep7ezoko	47	5	and	and	CC
cord-316534-ep7ezoko	47	6	cell	cell	NN
cord-316534-ep7ezoko	47	7	-	-	HYPH
cord-316534-ep7ezoko	47	8	mediated	mediate	VBN
cord-316534-ep7ezoko	47	9	immunity	immunity	NN
cord-316534-ep7ezoko	47	10	would	would	MD
cord-316534-ep7ezoko	47	11	be	be	VB
cord-316534-ep7ezoko	47	12	induced	induce	VBN
cord-316534-ep7ezoko	47	13	creating	create	VBG
cord-316534-ep7ezoko	47	14	long	long	RB
cord-316534-ep7ezoko	47	15	-	-	HYPH
cord-316534-ep7ezoko	47	16	lasting	last	VBG
cord-316534-ep7ezoko	47	17	immunity	immunity	NN
cord-316534-ep7ezoko	47	18	.	.	.
cord-316534-ep7ezoko	48	1	Traditional	traditional	JJ
cord-316534-ep7ezoko	48	2	attempts	attempt	NNS
cord-316534-ep7ezoko	48	3	to	to	TO
cord-316534-ep7ezoko	48	4	recreate	recreate	VB
cord-316534-ep7ezoko	48	5	this	this	DT
cord-316534-ep7ezoko	48	6	process	process	NN
cord-316534-ep7ezoko	48	7	using	use	VBG
cord-316534-ep7ezoko	48	8	live	live	JJ
cord-316534-ep7ezoko	48	9	attenuated	attenuated	JJ
cord-316534-ep7ezoko	48	10	simian	simian	JJ
cord-316534-ep7ezoko	48	11	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	48	12	virus-1	virus-1	NN
cord-316534-ep7ezoko	48	13	(	(	-LRB-
cord-316534-ep7ezoko	48	14	SIV-1	SIV-1	NNP
cord-316534-ep7ezoko	48	15	)	)	-RRB-
cord-316534-ep7ezoko	48	16	viruses	virus	NNS
cord-316534-ep7ezoko	48	17	in	in	IN
cord-316534-ep7ezoko	48	18	an	an	DT
cord-316534-ep7ezoko	48	19	effort	effort	NN
cord-316534-ep7ezoko	48	20	to	to	TO
cord-316534-ep7ezoko	48	21	vaccinate	vaccinate	VB
cord-316534-ep7ezoko	48	22	macaques	macaque	NNS
cord-316534-ep7ezoko	48	23	against	against	IN
cord-316534-ep7ezoko	48	24	SIV-1	SIV-1	NNS
cord-316534-ep7ezoko	48	25	have	have	VBP
cord-316534-ep7ezoko	48	26	been	be	VBN
cord-316534-ep7ezoko	48	27	proven	prove	VBN
cord-316534-ep7ezoko	48	28	safe	safe	JJ
cord-316534-ep7ezoko	48	29	and	and	CC
cord-316534-ep7ezoko	48	30	effective	effective	JJ
cord-316534-ep7ezoko	48	31	in	in	IN
cord-316534-ep7ezoko	48	32	macaques	macaque	NNS
cord-316534-ep7ezoko	48	33	that	that	WDT
cord-316534-ep7ezoko	48	34	were	be	VBD
cord-316534-ep7ezoko	48	35	subsequently	subsequently	RB
cord-316534-ep7ezoko	48	36	challenged	challenge	VBN
cord-316534-ep7ezoko	48	37	with	with	IN
cord-316534-ep7ezoko	48	38	SIV-1	SIV-1	NNP
cord-316534-ep7ezoko	48	39	.	.	.
cord-316534-ep7ezoko	49	1	14	14	CD
cord-316534-ep7ezoko	49	2	,	,	,
cord-316534-ep7ezoko	49	3	15	15	CD
cord-316534-ep7ezoko	50	1	However	however	RB
cord-316534-ep7ezoko	50	2	,	,	,
cord-316534-ep7ezoko	50	3	an	an	DT
cord-316534-ep7ezoko	50	4	incidental	incidental	JJ
cord-316534-ep7ezoko	50	5	study	study	NN
cord-316534-ep7ezoko	50	6	of	of	IN
cord-316534-ep7ezoko	50	7	the	the	DT
cord-316534-ep7ezoko	50	8	effect	effect	NN
cord-316534-ep7ezoko	50	9	of	of	IN
cord-316534-ep7ezoko	50	10	liveattenuated	liveattenuate	VBN
cord-316534-ep7ezoko	50	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	50	12	(	(	-LRB-
cord-316534-ep7ezoko	50	13	containing	contain	VBG
cord-316534-ep7ezoko	50	14	deletions	deletion	NNS
cord-316534-ep7ezoko	50	15	of	of	IN
cord-316534-ep7ezoko	50	16	the	the	DT
cord-316534-ep7ezoko	50	17	nef	nef	NNP
cord-316534-ep7ezoko	50	18	gene	gene	NN
cord-316534-ep7ezoko	50	19	and	and	CC
cord-316534-ep7ezoko	50	20	the	the	DT
cord-316534-ep7ezoko	50	21	long	long	JJ
cord-316534-ep7ezoko	50	22	terminal	terminal	NN
cord-316534-ep7ezoko	50	23	repeat	repeat	NN
cord-316534-ep7ezoko	50	24	)	)	-RRB-
cord-316534-ep7ezoko	50	25	was	be	VBD
cord-316534-ep7ezoko	50	26	proven	prove	VBN
cord-316534-ep7ezoko	50	27	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	50	28	in	in	IN
cord-316534-ep7ezoko	50	29	humans	human	NNS
cord-316534-ep7ezoko	50	30	when	when	WRB
cord-316534-ep7ezoko	50	31	three	three	CD
cord-316534-ep7ezoko	50	32	out	out	IN
cord-316534-ep7ezoko	50	33	of	of	IN
cord-316534-ep7ezoko	50	34	six	six	CD
cord-316534-ep7ezoko	50	35	treated	treat	VBN
cord-316534-ep7ezoko	50	36	patients	patient	NNS
cord-316534-ep7ezoko	50	37	developed	develop	VBD
cord-316534-ep7ezoko	50	38	late	late	JJ
cord-316534-ep7ezoko	50	39	-	-	HYPH
cord-316534-ep7ezoko	50	40	onset	onset	NN
cord-316534-ep7ezoko	50	41	immunosuppression	immunosuppression	NN
cord-316534-ep7ezoko	50	42	.	.	.
cord-316534-ep7ezoko	51	1	[	[	-LRB-
cord-316534-ep7ezoko	51	2	16	16	CD
cord-316534-ep7ezoko	51	3	]	]	-RRB-
cord-316534-ep7ezoko	51	4	[	[	-LRB-
cord-316534-ep7ezoko	51	5	17	17	CD
cord-316534-ep7ezoko	51	6	]	]	-RRB-
cord-316534-ep7ezoko	52	1	[	[	-LRB-
cord-316534-ep7ezoko	52	2	18	18	CD
cord-316534-ep7ezoko	52	3	]	]	-RRB-
cord-316534-ep7ezoko	52	4	Killed	kill	VBN
cord-316534-ep7ezoko	52	5	viruses	virus	NNS
cord-316534-ep7ezoko	52	6	have	have	VBP
cord-316534-ep7ezoko	52	7	also	also	RB
cord-316534-ep7ezoko	52	8	been	be	VBN
cord-316534-ep7ezoko	52	9	tested	test	VBN
cord-316534-ep7ezoko	52	10	as	as	IN
cord-316534-ep7ezoko	52	11	a	a	DT
cord-316534-ep7ezoko	52	12	potential	potential	JJ
cord-316534-ep7ezoko	52	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	52	14	approach	approach	NN
cord-316534-ep7ezoko	52	15	,	,	,
cord-316534-ep7ezoko	52	16	but	but	CC
cord-316534-ep7ezoko	52	17	safety	safety	NN
cord-316534-ep7ezoko	52	18	concerns	concern	NNS
cord-316534-ep7ezoko	52	19	have	have	VBP
cord-316534-ep7ezoko	52	20	halted	halt	VBN
cord-316534-ep7ezoko	52	21	their	-PRON-	PRP$
cord-316534-ep7ezoko	52	22	use	use	NN
cord-316534-ep7ezoko	52	23	.	.	.
cord-316534-ep7ezoko	53	1	These	these	DT
cord-316534-ep7ezoko	53	2	safety	safety	NN
cord-316534-ep7ezoko	53	3	concerns	concern	NNS
cord-316534-ep7ezoko	53	4	include	include	VBP
cord-316534-ep7ezoko	53	5	incomplete	incomplete	JJ
cord-316534-ep7ezoko	53	6	inactivation	inactivation	NN
cord-316534-ep7ezoko	53	7	of	of	IN
cord-316534-ep7ezoko	53	8	the	the	DT
cord-316534-ep7ezoko	53	9	virus	virus	NN
cord-316534-ep7ezoko	53	10	leading	lead	VBG
cord-316534-ep7ezoko	53	11	to	to	IN
cord-316534-ep7ezoko	53	12	potential	potential	JJ
cord-316534-ep7ezoko	53	13	residual	residual	JJ
cord-316534-ep7ezoko	53	14	infectivity	infectivity	NN
cord-316534-ep7ezoko	53	15	during	during	IN
cord-316534-ep7ezoko	53	16	the	the	DT
cord-316534-ep7ezoko	53	17	vaccine	vaccine	NN
cord-316534-ep7ezoko	53	18	preparation	preparation	NN
cord-316534-ep7ezoko	53	19	.	.	.
cord-316534-ep7ezoko	54	1	19	19	CD
cord-316534-ep7ezoko	55	1	Due	due	IN
cord-316534-ep7ezoko	55	2	to	to	IN
cord-316534-ep7ezoko	55	3	the	the	DT
cord-316534-ep7ezoko	55	4	ineffectiveness	ineffectiveness	NN
cord-316534-ep7ezoko	55	5	of	of	IN
cord-316534-ep7ezoko	55	6	traditional	traditional	JJ
cord-316534-ep7ezoko	55	7	vaccine	vaccine	NN
cord-316534-ep7ezoko	55	8	approaches	approach	NNS
cord-316534-ep7ezoko	55	9	to	to	IN
cord-316534-ep7ezoko	55	10	date	date	NN
cord-316534-ep7ezoko	55	11	,	,	,
cord-316534-ep7ezoko	55	12	scientists	scientist	NNS
cord-316534-ep7ezoko	55	13	have	have	VBP
cord-316534-ep7ezoko	55	14	attempted	attempt	VBN
cord-316534-ep7ezoko	55	15	to	to	TO
cord-316534-ep7ezoko	55	16	use	use	VB
cord-316534-ep7ezoko	55	17	recombinant	recombinant	JJ
cord-316534-ep7ezoko	55	18	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	55	19	proteins	protein	NNS
cord-316534-ep7ezoko	55	20	to	to	TO
cord-316534-ep7ezoko	55	21	stimulate	stimulate	VB
cord-316534-ep7ezoko	55	22	the	the	DT
cord-316534-ep7ezoko	55	23	production	production	NN
cord-316534-ep7ezoko	55	24	of	of	IN
cord-316534-ep7ezoko	55	25	Nabs	Nabs	NNP
cord-316534-ep7ezoko	55	26	.	.	.
cord-316534-ep7ezoko	56	1	These	these	DT
cord-316534-ep7ezoko	56	2	attempts	attempt	NNS
cord-316534-ep7ezoko	56	3	failed	fail	VBD
cord-316534-ep7ezoko	56	4	due	due	IN
cord-316534-ep7ezoko	56	5	to	to	IN
cord-316534-ep7ezoko	56	6	their	-PRON-	PRP$
cord-316534-ep7ezoko	56	7	inability	inability	NN
cord-316534-ep7ezoko	56	8	to	to	TO
cord-316534-ep7ezoko	56	9	induce	induce	VB
cord-316534-ep7ezoko	56	10	a	a	DT
cord-316534-ep7ezoko	56	11	lasting	lasting	JJ
cord-316534-ep7ezoko	56	12	,	,	,
cord-316534-ep7ezoko	56	13	broad	broad	JJ
cord-316534-ep7ezoko	56	14	range	range	NN
cord-316534-ep7ezoko	56	15	of	of	IN
cord-316534-ep7ezoko	56	16	Nabs	Nabs	NNP
cord-316534-ep7ezoko	56	17	that	that	WDT
cord-316534-ep7ezoko	56	18	would	would	MD
cord-316534-ep7ezoko	56	19	inhibit	inhibit	VB
cord-316534-ep7ezoko	56	20	infection	infection	NN
cord-316534-ep7ezoko	56	21	in	in	IN
cord-316534-ep7ezoko	56	22	humans	human	NNS
cord-316534-ep7ezoko	56	23	.	.	.
cord-316534-ep7ezoko	57	1	[	[	-LRB-
cord-316534-ep7ezoko	57	2	20	20	CD
cord-316534-ep7ezoko	57	3	]	]	-RRB-
cord-316534-ep7ezoko	57	4	[	[	-LRB-
cord-316534-ep7ezoko	57	5	21	21	CD
cord-316534-ep7ezoko	57	6	]	]	-RRB-
cord-316534-ep7ezoko	57	7	[	[	-LRB-
cord-316534-ep7ezoko	57	8	22	22	CD
cord-316534-ep7ezoko	57	9	]	]	-RRB-
cord-316534-ep7ezoko	58	1	[	[	-LRB-
cord-316534-ep7ezoko	58	2	23	23	CD
cord-316534-ep7ezoko	58	3	]	]	-RRB-
cord-316534-ep7ezoko	59	1	Perhaps	perhaps	RB
cord-316534-ep7ezoko	59	2	these	these	DT
cord-316534-ep7ezoko	59	3	failures	failure	NNS
cord-316534-ep7ezoko	59	4	are	be	VBP
cord-316534-ep7ezoko	59	5	a	a	DT
cord-316534-ep7ezoko	59	6	result	result	NN
cord-316534-ep7ezoko	59	7	of	of	IN
cord-316534-ep7ezoko	59	8	the	the	DT
cord-316534-ep7ezoko	59	9	inherent	inherent	JJ
cord-316534-ep7ezoko	59	10	diversity	diversity	NN
cord-316534-ep7ezoko	59	11	of	of	IN
cord-316534-ep7ezoko	59	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	59	13	.	.	.
cord-316534-ep7ezoko	60	1	This	this	DT
cord-316534-ep7ezoko	60	2	diversity	diversity	NN
cord-316534-ep7ezoko	60	3	has	have	VBZ
cord-316534-ep7ezoko	60	4	presented	present	VBN
cord-316534-ep7ezoko	60	5	a	a	DT
cord-316534-ep7ezoko	60	6	major	major	JJ
cord-316534-ep7ezoko	60	7	roadblock	roadblock	NN
cord-316534-ep7ezoko	60	8	to	to	IN
cord-316534-ep7ezoko	60	9	development	development	NN
cord-316534-ep7ezoko	60	10	of	of	IN
cord-316534-ep7ezoko	60	11	a	a	DT
cord-316534-ep7ezoko	60	12	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	60	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	60	14	.	.	.
cord-316534-ep7ezoko	61	1	There	there	EX
cord-316534-ep7ezoko	61	2	are	be	VBP
cord-316534-ep7ezoko	61	3	three	three	CD
cord-316534-ep7ezoko	61	4	main	main	JJ
cord-316534-ep7ezoko	61	5	groups	group	NNS
cord-316534-ep7ezoko	61	6	of	of	IN
cord-316534-ep7ezoko	61	7	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	61	8	(	(	-LRB-
cord-316534-ep7ezoko	61	9	M	M	NNP
cord-316534-ep7ezoko	61	10	,	,	,
cord-316534-ep7ezoko	61	11	O	o	UH
cord-316534-ep7ezoko	61	12	,	,	,
cord-316534-ep7ezoko	61	13	and	and	CC
cord-316534-ep7ezoko	61	14	N	n	CD
cord-316534-ep7ezoko	61	15	)	)	-RRB-
cord-316534-ep7ezoko	61	16	24	24	CD
cord-316534-ep7ezoko	61	17	as	as	RB
cord-316534-ep7ezoko	61	18	well	well	RB
cord-316534-ep7ezoko	61	19	as	as	IN
cord-316534-ep7ezoko	61	20	a	a	DT
cord-316534-ep7ezoko	61	21	recently	recently	RB
cord-316534-ep7ezoko	61	22	discovered	discover	VBN
cord-316534-ep7ezoko	61	23	group	group	NN
cord-316534-ep7ezoko	61	24	,	,	,
cord-316534-ep7ezoko	61	25	P.	P.	NNP
cord-316534-ep7ezoko	61	26	25	25	CD
cord-316534-ep7ezoko	62	1	Each	each	DT
cord-316534-ep7ezoko	62	2	group	group	NN
cord-316534-ep7ezoko	62	3	consists	consist	VBZ
cord-316534-ep7ezoko	62	4	of	of	IN
cord-316534-ep7ezoko	62	5	several	several	JJ
cord-316534-ep7ezoko	62	6	subtypes	subtype	NNS
cord-316534-ep7ezoko	62	7	,	,	,
cord-316534-ep7ezoko	62	8	clades	clade	NNS
cord-316534-ep7ezoko	62	9	.	.	.
cord-316534-ep7ezoko	63	1	The	the	DT
cord-316534-ep7ezoko	63	2	various	various	JJ
cord-316534-ep7ezoko	63	3	clades	clade	NNS
cord-316534-ep7ezoko	63	4	display	display	VBP
cord-316534-ep7ezoko	63	5	biological	biological	JJ
cord-316534-ep7ezoko	63	6	differences	difference	NNS
cord-316534-ep7ezoko	63	7	with	with	IN
cord-316534-ep7ezoko	63	8	respect	respect	NN
cord-316534-ep7ezoko	63	9	to	to	IN
cord-316534-ep7ezoko	63	10	transmission	transmission	NN
cord-316534-ep7ezoko	63	11	,	,	,
cord-316534-ep7ezoko	63	12	26	26	CD
cord-316534-ep7ezoko	63	13	replication	replication	NN
cord-316534-ep7ezoko	63	14	,	,	,
cord-316534-ep7ezoko	63	15	27	27	CD
cord-316534-ep7ezoko	63	16	and	and	CC
cord-316534-ep7ezoko	63	17	disease	disease	NN
cord-316534-ep7ezoko	63	18	progression	progression	NN
cord-316534-ep7ezoko	63	19	.	.	.
cord-316534-ep7ezoko	64	1	28	28	CD
cord-316534-ep7ezoko	64	2	,	,	,
cord-316534-ep7ezoko	64	3	29	29	CD
cord-316534-ep7ezoko	65	1	These	these	DT
cord-316534-ep7ezoko	65	2	differences	difference	NNS
cord-316534-ep7ezoko	65	3	result	result	VBP
cord-316534-ep7ezoko	65	4	in	in	IN
cord-316534-ep7ezoko	65	5	an	an	DT
cord-316534-ep7ezoko	65	6	inability	inability	NN
cord-316534-ep7ezoko	65	7	to	to	TO
cord-316534-ep7ezoko	65	8	produce	produce	VB
cord-316534-ep7ezoko	65	9	a	a	DT
cord-316534-ep7ezoko	65	10	generalizable	generalizable	JJ
cord-316534-ep7ezoko	65	11	vaccine	vaccine	NN
cord-316534-ep7ezoko	65	12	that	that	WDT
cord-316534-ep7ezoko	65	13	would	would	MD
cord-316534-ep7ezoko	65	14	induce	induce	VB
cord-316534-ep7ezoko	65	15	the	the	DT
cord-316534-ep7ezoko	65	16	breadth	breadth	NN
cord-316534-ep7ezoko	65	17	of	of	IN
cord-316534-ep7ezoko	65	18	Nabs	Nabs	NNP
cord-316534-ep7ezoko	65	19	necessary	necessary	JJ
cord-316534-ep7ezoko	65	20	to	to	TO
cord-316534-ep7ezoko	65	21	counter	counter	VB
cord-316534-ep7ezoko	65	22	an	an	DT
cord-316534-ep7ezoko	65	23	infection	infection	NN
cord-316534-ep7ezoko	65	24	by	by	IN
cord-316534-ep7ezoko	65	25	a	a	DT
cord-316534-ep7ezoko	65	26	wide	wide	JJ
cord-316534-ep7ezoko	65	27	range	range	NN
cord-316534-ep7ezoko	65	28	of	of	IN
cord-316534-ep7ezoko	65	29	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	65	30	clades	clade	NNS
cord-316534-ep7ezoko	65	31	that	that	WDT
cord-316534-ep7ezoko	65	32	may	may	MD
cord-316534-ep7ezoko	65	33	be	be	VB
cord-316534-ep7ezoko	65	34	encountered	encounter	VBN
cord-316534-ep7ezoko	65	35	in	in	IN
cord-316534-ep7ezoko	65	36	a	a	DT
cord-316534-ep7ezoko	65	37	natural	natural	JJ
cord-316534-ep7ezoko	65	38	setting	setting	NN
cord-316534-ep7ezoko	65	39	.	.	.
cord-316534-ep7ezoko	66	1	30	30	CD
cord-316534-ep7ezoko	67	1	The	the	DT
cord-316534-ep7ezoko	67	2	degree	degree	NN
cord-316534-ep7ezoko	67	3	of	of	IN
cord-316534-ep7ezoko	67	4	diversity	diversity	NN
cord-316534-ep7ezoko	67	5	seen	see	VBN
cord-316534-ep7ezoko	67	6	in	in	IN
cord-316534-ep7ezoko	67	7	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	67	8	is	be	VBZ
cord-316534-ep7ezoko	67	9	greater	great	JJR
cord-316534-ep7ezoko	67	10	than	than	IN
cord-316534-ep7ezoko	67	11	that	that	DT
cord-316534-ep7ezoko	67	12	of	of	IN
cord-316534-ep7ezoko	67	13	any	any	DT
cord-316534-ep7ezoko	67	14	other	other	JJ
cord-316534-ep7ezoko	67	15	virus	virus	NN
cord-316534-ep7ezoko	67	16	observed	observe	VBN
cord-316534-ep7ezoko	67	17	.	.	.
cord-316534-ep7ezoko	68	1	31	31	CD
cord-316534-ep7ezoko	68	2	,	,	,
cord-316534-ep7ezoko	68	3	32	32	CD
cord-316534-ep7ezoko	68	4	This	this	DT
cord-316534-ep7ezoko	68	5	problem	problem	NN
cord-316534-ep7ezoko	68	6	is	be	VBZ
cord-316534-ep7ezoko	68	7	being	be	VBG
cord-316534-ep7ezoko	68	8	addressed	address	VBN
cord-316534-ep7ezoko	68	9	by	by	IN
cord-316534-ep7ezoko	68	10	development	development	NN
cord-316534-ep7ezoko	68	11	of	of	IN
cord-316534-ep7ezoko	68	12	multiclade	multiclade	NNP
cord-316534-ep7ezoko	68	13	(	(	-LRB-
cord-316534-ep7ezoko	69	1	multiple	multiple	JJ
cord-316534-ep7ezoko	69	2	env	env	NNP
cord-316534-ep7ezoko	69	3	and/	and/	CD
cord-316534-ep7ezoko	70	1	or	or	CC
cord-316534-ep7ezoko	70	2	subtype	subtype	NN
cord-316534-ep7ezoko	70	3	B	b	NN
cord-316534-ep7ezoko	70	4	gag	gag	NN
cord-316534-ep7ezoko	70	5	,	,	,
cord-316534-ep7ezoko	70	6	pol	pol	NN
cord-316534-ep7ezoko	70	7	,	,	,
cord-316534-ep7ezoko	70	8	nef	nef	NNP
cord-316534-ep7ezoko	70	9	)	)	-RRB-
cord-316534-ep7ezoko	70	10	33	33	CD
cord-316534-ep7ezoko	70	11	,	,	,
cord-316534-ep7ezoko	70	12	34	34	CD
cord-316534-ep7ezoko	70	13	and	and	CC
cord-316534-ep7ezoko	70	14	mosaic	mosaic	JJ
cord-316534-ep7ezoko	70	15	vaccines	vaccine	NNS
cord-316534-ep7ezoko	70	16	which	which	WDT
cord-316534-ep7ezoko	70	17	incorporate	incorporate	VBP
cord-316534-ep7ezoko	70	18	sets	set	NNS
cord-316534-ep7ezoko	70	19	of	of	IN
cord-316534-ep7ezoko	70	20	10	10	CD
cord-316534-ep7ezoko	70	21	immunogenic	immunogenic	JJ
cord-316534-ep7ezoko	70	22	proteins	protein	NNS
cord-316534-ep7ezoko	70	23	from	from	IN
cord-316534-ep7ezoko	70	24	4	4	CD
cord-316534-ep7ezoko	70	25	different	different	JJ
cord-316534-ep7ezoko	70	26	clades	clade	NNS
cord-316534-ep7ezoko	70	27	or	or	CC
cord-316534-ep7ezoko	70	28	bivalent	bivalent	JJ
cord-316534-ep7ezoko	70	29	proteins	protein	NNS
cord-316534-ep7ezoko	70	30	from	from	IN
cord-316534-ep7ezoko	70	31	clades	clade	NNS
cord-316534-ep7ezoko	70	32	B	b	NN
cord-316534-ep7ezoko	70	33	and	and	CC
cord-316534-ep7ezoko	70	34	C.	C.	NNP
cord-316534-ep7ezoko	70	35	[	[	-LRB-
cord-316534-ep7ezoko	70	36	35	35	CD
cord-316534-ep7ezoko	70	37	]	]	-RRB-
cord-316534-ep7ezoko	70	38	[	[	-LRB-
cord-316534-ep7ezoko	70	39	36	36	CD
cord-316534-ep7ezoko	70	40	]	]	-RRB-
cord-316534-ep7ezoko	71	1	[	[	-LRB-
cord-316534-ep7ezoko	71	2	37	37	CD
cord-316534-ep7ezoko	71	3	]	]	-RRB-
cord-316534-ep7ezoko	72	1	There	there	EX
cord-316534-ep7ezoko	72	2	are	be	VBP
cord-316534-ep7ezoko	72	3	proof	proof	NN
cord-316534-ep7ezoko	72	4	of	of	IN
cord-316534-ep7ezoko	72	5	principle	principle	JJ
cord-316534-ep7ezoko	72	6	studies	study	NNS
cord-316534-ep7ezoko	72	7	that	that	WDT
cord-316534-ep7ezoko	72	8	illustrate	illustrate	VBP
cord-316534-ep7ezoko	72	9	immunological	immunological	JJ
cord-316534-ep7ezoko	72	10	protection	protection	NN
cord-316534-ep7ezoko	72	11	against	against	IN
cord-316534-ep7ezoko	72	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	72	13	in	in	IN
cord-316534-ep7ezoko	72	14	nonhuman	nonhuman	NN
cord-316534-ep7ezoko	72	15	primates	primate	NNS
cord-316534-ep7ezoko	72	16	that	that	WDT
cord-316534-ep7ezoko	72	17	were	be	VBD
cord-316534-ep7ezoko	72	18	passively	passively	RB
cord-316534-ep7ezoko	72	19	treated	treat	VBN
cord-316534-ep7ezoko	72	20	with	with	IN
cord-316534-ep7ezoko	72	21	broadly	broadly	RB
cord-316534-ep7ezoko	72	22	reactive	reactive	JJ
cord-316534-ep7ezoko	72	23	Nabs	Nabs	NNP
cord-316534-ep7ezoko	72	24	.	.	.
cord-316534-ep7ezoko	73	1	[	[	-LRB-
cord-316534-ep7ezoko	73	2	38	38	CD
cord-316534-ep7ezoko	73	3	]	]	-RRB-
cord-316534-ep7ezoko	73	4	[	[	-LRB-
cord-316534-ep7ezoko	73	5	39	39	CD
cord-316534-ep7ezoko	73	6	]	]	-RRB-
cord-316534-ep7ezoko	74	1	[	[	-LRB-
cord-316534-ep7ezoko	74	2	40	40	CD
cord-316534-ep7ezoko	74	3	]	]	-RRB-
cord-316534-ep7ezoko	75	1	These	these	DT
cord-316534-ep7ezoko	75	2	studies	study	NNS
cord-316534-ep7ezoko	75	3	show	show	VBP
cord-316534-ep7ezoko	75	4	that	that	IN
cord-316534-ep7ezoko	75	5	protection	protection	NN
cord-316534-ep7ezoko	75	6	against	against	IN
cord-316534-ep7ezoko	75	7	infection	infection	NN
cord-316534-ep7ezoko	75	8	with	with	IN
cord-316534-ep7ezoko	75	9	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	75	10	can	can	MD
cord-316534-ep7ezoko	75	11	be	be	VB
cord-316534-ep7ezoko	75	12	conferred	confer	VBN
cord-316534-ep7ezoko	75	13	by	by	IN
cord-316534-ep7ezoko	75	14	the	the	DT
cord-316534-ep7ezoko	75	15	presence	presence	NN
cord-316534-ep7ezoko	75	16	of	of	IN
cord-316534-ep7ezoko	75	17	broadly	broadly	RB
cord-316534-ep7ezoko	75	18	reactive	reactive	JJ
cord-316534-ep7ezoko	75	19	Nabs	Nabs	NNP
cord-316534-ep7ezoko	75	20	.	.	.
cord-316534-ep7ezoko	76	1	The	the	DT
cord-316534-ep7ezoko	76	2	next	next	JJ
cord-316534-ep7ezoko	76	3	step	step	NN
cord-316534-ep7ezoko	76	4	toward	toward	IN
cord-316534-ep7ezoko	76	5	production	production	NN
cord-316534-ep7ezoko	76	6	of	of	IN
cord-316534-ep7ezoko	76	7	a	a	DT
cord-316534-ep7ezoko	76	8	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	76	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	76	10	would	would	MD
cord-316534-ep7ezoko	76	11	involve	involve	VB
cord-316534-ep7ezoko	76	12	induction	induction	NN
cord-316534-ep7ezoko	76	13	of	of	IN
cord-316534-ep7ezoko	76	14	production	production	NN
cord-316534-ep7ezoko	76	15	of	of	IN
cord-316534-ep7ezoko	76	16	these	these	DT
cord-316534-ep7ezoko	76	17	or	or	CC
cord-316534-ep7ezoko	76	18	similar	similar	JJ
cord-316534-ep7ezoko	76	19	broadly	broadly	RB
cord-316534-ep7ezoko	76	20	reactive	reactive	JJ
cord-316534-ep7ezoko	76	21	Nabs	Nabs	NNP
cord-316534-ep7ezoko	76	22	by	by	IN
cord-316534-ep7ezoko	76	23	the	the	DT
cord-316534-ep7ezoko	76	24	host	host	NN
cord-316534-ep7ezoko	76	25	's	's	POS
cord-316534-ep7ezoko	76	26	immune	immune	JJ
cord-316534-ep7ezoko	76	27	system	system	NN
cord-316534-ep7ezoko	76	28	.	.	.
cord-316534-ep7ezoko	77	1	The	the	DT
cord-316534-ep7ezoko	77	2	rate	rate	NN
cord-316534-ep7ezoko	77	3	at	at	IN
cord-316534-ep7ezoko	77	4	which	which	WDT
cord-316534-ep7ezoko	77	5	the	the	DT
cord-316534-ep7ezoko	77	6	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	77	7	virus	virus	NN
cord-316534-ep7ezoko	77	8	mutates	mutate	VBZ
cord-316534-ep7ezoko	77	9	,	,	,
cord-316534-ep7ezoko	77	10	due	due	IN
cord-316534-ep7ezoko	77	11	to	to	IN
cord-316534-ep7ezoko	77	12	the	the	DT
cord-316534-ep7ezoko	77	13	nature	nature	NN
cord-316534-ep7ezoko	77	14	of	of	IN
cord-316534-ep7ezoko	77	15	the	the	DT
cord-316534-ep7ezoko	77	16	reverse	reverse	JJ
cord-316534-ep7ezoko	77	17	transcriptase	transcriptase	NN
cord-316534-ep7ezoko	77	18	enzyme	enzyme	NN
cord-316534-ep7ezoko	77	19	responsible	responsible	JJ
cord-316534-ep7ezoko	77	20	for	for	IN
cord-316534-ep7ezoko	77	21	transcribing	transcribe	VBG
cord-316534-ep7ezoko	77	22	its	-PRON-	PRP$
cord-316534-ep7ezoko	77	23	RNA	RNA	NNP
cord-316534-ep7ezoko	77	24	,	,	,
cord-316534-ep7ezoko	77	25	ensures	ensure	VBZ
cord-316534-ep7ezoko	77	26	that	that	IN
cord-316534-ep7ezoko	77	27	nearly	nearly	RB
cord-316534-ep7ezoko	77	28	every	every	DT
cord-316534-ep7ezoko	77	29	daughter	daughter	NN
cord-316534-ep7ezoko	77	30	virion	virion	NN
cord-316534-ep7ezoko	77	31	will	will	MD
cord-316534-ep7ezoko	77	32	have	have	VB
cord-316534-ep7ezoko	77	33	a	a	DT
cord-316534-ep7ezoko	77	34	different	different	JJ
cord-316534-ep7ezoko	77	35	genome	genome	NN
cord-316534-ep7ezoko	77	36	than	than	IN
cord-316534-ep7ezoko	77	37	its	-PRON-	PRP$
cord-316534-ep7ezoko	77	38	parent	parent	NN
cord-316534-ep7ezoko	77	39	.	.	.
cord-316534-ep7ezoko	78	1	41	41	CD
cord-316534-ep7ezoko	79	1	When	when	WRB
cord-316534-ep7ezoko	79	2	these	these	DT
cord-316534-ep7ezoko	79	3	changes	change	NNS
cord-316534-ep7ezoko	79	4	occur	occur	VBP
cord-316534-ep7ezoko	79	5	in	in	IN
cord-316534-ep7ezoko	79	6	the	the	DT
cord-316534-ep7ezoko	79	7	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	79	8	Env	Env	NNP
cord-316534-ep7ezoko	79	9	protein	protein	NN
cord-316534-ep7ezoko	79	10	that	that	WDT
cord-316534-ep7ezoko	79	11	is	be	VBZ
cord-316534-ep7ezoko	79	12	needed	need	VBN
cord-316534-ep7ezoko	79	13	for	for	IN
cord-316534-ep7ezoko	79	14	antibody	antibody	NN
cord-316534-ep7ezoko	79	15	recognition	recognition	NN
cord-316534-ep7ezoko	79	16	,	,	,
cord-316534-ep7ezoko	79	17	they	-PRON-	PRP
cord-316534-ep7ezoko	79	18	inhibit	inhibit	VBP
cord-316534-ep7ezoko	79	19	the	the	DT
cord-316534-ep7ezoko	79	20	immune	immune	JJ
cord-316534-ep7ezoko	79	21	system	system	NN
cord-316534-ep7ezoko	79	22	's	's	POS
cord-316534-ep7ezoko	79	23	ability	ability	NN
cord-316534-ep7ezoko	79	24	to	to	TO
cord-316534-ep7ezoko	79	25	mount	mount	VB
cord-316534-ep7ezoko	79	26	a	a	DT
cord-316534-ep7ezoko	79	27	sufficient	sufficient	JJ
cord-316534-ep7ezoko	79	28	response	response	NN
cord-316534-ep7ezoko	79	29	.	.	.
cord-316534-ep7ezoko	80	1	One	one	CD
cord-316534-ep7ezoko	80	2	attempt	attempt	NN
cord-316534-ep7ezoko	80	3	to	to	TO
cord-316534-ep7ezoko	80	4	circumvent	circumvent	VB
cord-316534-ep7ezoko	80	5	this	this	DT
cord-316534-ep7ezoko	80	6	problem	problem	NN
cord-316534-ep7ezoko	80	7	has	have	VBZ
cord-316534-ep7ezoko	80	8	been	be	VBN
cord-316534-ep7ezoko	80	9	to	to	TO
cord-316534-ep7ezoko	80	10	induce	induce	VB
cord-316534-ep7ezoko	80	11	the	the	DT
cord-316534-ep7ezoko	80	12	production	production	NN
cord-316534-ep7ezoko	80	13	of	of	IN
cord-316534-ep7ezoko	80	14	Nabs	Nabs	NNP
cord-316534-ep7ezoko	80	15	to	to	IN
cord-316534-ep7ezoko	80	16	the	the	DT
cord-316534-ep7ezoko	80	17	conserved	conserve	VBN
cord-316534-ep7ezoko	80	18	regions	region	NNS
cord-316534-ep7ezoko	80	19	of	of	IN
cord-316534-ep7ezoko	80	20	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	80	21	proteins	protein	NNS
cord-316534-ep7ezoko	80	22	.	.	.
cord-316534-ep7ezoko	81	1	A	a	DT
cord-316534-ep7ezoko	81	2	major	major	JJ
cord-316534-ep7ezoko	81	3	problem	problem	NN
cord-316534-ep7ezoko	81	4	with	with	IN
cord-316534-ep7ezoko	81	5	this	this	DT
cord-316534-ep7ezoko	81	6	approach	approach	NN
cord-316534-ep7ezoko	81	7	is	be	VBZ
cord-316534-ep7ezoko	81	8	that	that	IN
cord-316534-ep7ezoko	81	9	the	the	DT
cord-316534-ep7ezoko	81	10	conserved	conserved	JJ
cord-316534-ep7ezoko	81	11	regions	region	NNS
cord-316534-ep7ezoko	81	12	of	of	IN
cord-316534-ep7ezoko	81	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	81	14	proteins	protein	NNS
cord-316534-ep7ezoko	81	15	are	be	VBP
cord-316534-ep7ezoko	81	16	often	often	RB
cord-316534-ep7ezoko	81	17	shielded	shield	VBN
cord-316534-ep7ezoko	81	18	from	from	IN
cord-316534-ep7ezoko	81	19	exposure	exposure	NN
cord-316534-ep7ezoko	81	20	to	to	IN
cord-316534-ep7ezoko	81	21	Nabs	Nabs	NNP
cord-316534-ep7ezoko	81	22	within	within	IN
cord-316534-ep7ezoko	81	23	the	the	DT
cord-316534-ep7ezoko	81	24	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	81	25	envelope	envelope	NN
cord-316534-ep7ezoko	81	26	.	.	.
cord-316534-ep7ezoko	82	1	The	the	DT
cord-316534-ep7ezoko	82	2	native	native	JJ
cord-316534-ep7ezoko	82	3	structure	structure	NN
cord-316534-ep7ezoko	82	4	of	of	IN
cord-316534-ep7ezoko	82	5	the	the	DT
cord-316534-ep7ezoko	82	6	envelope	envelope	NN
cord-316534-ep7ezoko	82	7	protein	protein	NN
cord-316534-ep7ezoko	82	8	,	,	,
cord-316534-ep7ezoko	82	9	reportedly	reportedly	RB
cord-316534-ep7ezoko	82	10	the	the	DT
cord-316534-ep7ezoko	82	11	only	only	JJ
cord-316534-ep7ezoko	82	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	82	13	protein	protein	NN
cord-316534-ep7ezoko	82	14	susceptible	susceptible	JJ
cord-316534-ep7ezoko	82	15	to	to	IN
cord-316534-ep7ezoko	82	16	Nabs	Nabs	NNP
cord-316534-ep7ezoko	82	17	,	,	,
cord-316534-ep7ezoko	82	18	31	31	CD
cord-316534-ep7ezoko	82	19	shields	shield	NNS
cord-316534-ep7ezoko	82	20	it	-PRON-	PRP
cord-316534-ep7ezoko	82	21	from	from	IN
cord-316534-ep7ezoko	82	22	the	the	DT
cord-316534-ep7ezoko	82	23	immune	immune	JJ
cord-316534-ep7ezoko	82	24	system	system	NN
cord-316534-ep7ezoko	82	25	as	as	IN
cord-316534-ep7ezoko	82	26	a	a	DT
cord-316534-ep7ezoko	82	27	glycosylated	glycosylated	JJ
cord-316534-ep7ezoko	82	28	trimer	trimer	NN
cord-316534-ep7ezoko	82	29	of	of	IN
cord-316534-ep7ezoko	82	30	heterodimers	heterodimer	NNS
cord-316534-ep7ezoko	82	31	.	.	.
cord-316534-ep7ezoko	83	1	The	the	DT
cord-316534-ep7ezoko	83	2	glycosylation	glycosylation	NN
cord-316534-ep7ezoko	83	3	of	of	IN
cord-316534-ep7ezoko	83	4	the	the	DT
cord-316534-ep7ezoko	83	5	envelope	envelope	NN
cord-316534-ep7ezoko	83	6	protein	protein	NN
cord-316534-ep7ezoko	83	7	allows	allow	VBZ
cord-316534-ep7ezoko	83	8	for	for	IN
cord-316534-ep7ezoko	83	9	the	the	DT
cord-316534-ep7ezoko	83	10	carbohydrates	carbohydrate	NNS
cord-316534-ep7ezoko	83	11	to	to	TO
cord-316534-ep7ezoko	83	12	masquerade	masquerade	VB
cord-316534-ep7ezoko	83	13	as	as	IN
cord-316534-ep7ezoko	83	14	'	'	``
cord-316534-ep7ezoko	83	15	self	self	NN
cord-316534-ep7ezoko	83	16	'	'	''
cord-316534-ep7ezoko	83	17	thereby	thereby	RB
cord-316534-ep7ezoko	83	18	forming	form	VBG
cord-316534-ep7ezoko	83	19	an	an	DT
cord-316534-ep7ezoko	83	20	immunologically	immunologically	RB
cord-316534-ep7ezoko	83	21	silent	silent	JJ
cord-316534-ep7ezoko	83	22	face	face	NN
cord-316534-ep7ezoko	83	23	and	and	CC
cord-316534-ep7ezoko	83	24	protects	protect	VBZ
cord-316534-ep7ezoko	83	25	neighboring	neighboring	NN
cord-316534-ep7ezoko	83	26	epitopes	epitope	NNS
cord-316534-ep7ezoko	83	27	via	via	IN
cord-316534-ep7ezoko	83	28	an	an	DT
cord-316534-ep7ezoko	83	29	'	'	``
cord-316534-ep7ezoko	83	30	evolving	evolve	VBG
cord-316534-ep7ezoko	83	31	glycan	glycan	NN
cord-316534-ep7ezoko	83	32	shield	shield	NN
cord-316534-ep7ezoko	83	33	'	'	''
cord-316534-ep7ezoko	83	34	.	.	.
cord-316534-ep7ezoko	84	1	[	[	-LRB-
cord-316534-ep7ezoko	84	2	42	42	CD
cord-316534-ep7ezoko	84	3	]	]	-RRB-
cord-316534-ep7ezoko	84	4	[	[	-LRB-
cord-316534-ep7ezoko	84	5	43	43	CD
cord-316534-ep7ezoko	84	6	]	]	-RRB-
cord-316534-ep7ezoko	84	7	[	[	-LRB-
cord-316534-ep7ezoko	84	8	44	44	CD
cord-316534-ep7ezoko	84	9	]	]	-RRB-
cord-316534-ep7ezoko	85	1	Additionally	additionally	RB
cord-316534-ep7ezoko	85	2	,	,	,
cord-316534-ep7ezoko	85	3	the	the	DT
cord-316534-ep7ezoko	85	4	gp41	gp41	NNP
cord-316534-ep7ezoko	85	5	coreceptor	coreceptor	NN
cord-316534-ep7ezoko	85	6	binding	binding	NN
cord-316534-ep7ezoko	85	7	site	site	NN
cord-316534-ep7ezoko	85	8	,	,	,
cord-316534-ep7ezoko	85	9	another	another	DT
cord-316534-ep7ezoko	85	10	conserved	conserve	VBN
cord-316534-ep7ezoko	85	11	site	site	NN
cord-316534-ep7ezoko	85	12	,	,	,
cord-316534-ep7ezoko	85	13	is	be	VBZ
cord-316534-ep7ezoko	85	14	not	not	RB
cord-316534-ep7ezoko	85	15	presented	present	VBN
cord-316534-ep7ezoko	85	16	until	until	IN
cord-316534-ep7ezoko	85	17	primary	primary	JJ
cord-316534-ep7ezoko	85	18	binding	binding	NN
cord-316534-ep7ezoko	85	19	to	to	IN
cord-316534-ep7ezoko	85	20	CD4	CD4	NNP
cord-316534-ep7ezoko	85	21	+	+	SYM
cord-316534-ep7ezoko	85	22	has	have	VBZ
cord-316534-ep7ezoko	85	23	occurred	occur	VBN
cord-316534-ep7ezoko	85	24	.	.	.
cord-316534-ep7ezoko	86	1	45	45	CD
cord-316534-ep7ezoko	87	1	An	an	DT
cord-316534-ep7ezoko	87	2	attempt	attempt	NN
cord-316534-ep7ezoko	87	3	to	to	TO
cord-316534-ep7ezoko	87	4	create	create	VB
cord-316534-ep7ezoko	87	5	antibodies	antibody	NNS
cord-316534-ep7ezoko	87	6	to	to	IN
cord-316534-ep7ezoko	87	7	the	the	DT
cord-316534-ep7ezoko	87	8	CD4-binding	cd4-binding	NN
cord-316534-ep7ezoko	87	9	region	region	NN
cord-316534-ep7ezoko	87	10	of	of	IN
cord-316534-ep7ezoko	87	11	the	the	DT
cord-316534-ep7ezoko	87	12	gp120	gp120	NNP
cord-316534-ep7ezoko	87	13	protein	protein	NN
cord-316534-ep7ezoko	87	14	was	be	VBD
cord-316534-ep7ezoko	87	15	made	make	VBN
cord-316534-ep7ezoko	87	16	in	in	IN
cord-316534-ep7ezoko	87	17	rhesus	rhesus	NN
cord-316534-ep7ezoko	87	18	macaques	macaque	NNS
cord-316534-ep7ezoko	87	19	in	in	IN
cord-316534-ep7ezoko	87	20	2007	2007	CD
cord-316534-ep7ezoko	87	21	and	and	CC
cord-316534-ep7ezoko	87	22	results	result	NNS
cord-316534-ep7ezoko	87	23	indicated	indicate	VBD
cord-316534-ep7ezoko	87	24	that	that	IN
cord-316534-ep7ezoko	87	25	vaccinated	vaccinate	VBN
cord-316534-ep7ezoko	87	26	hosts	host	NNS
cord-316534-ep7ezoko	87	27	were	be	VBD
cord-316534-ep7ezoko	87	28	able	able	JJ
cord-316534-ep7ezoko	87	29	to	to	TO
cord-316534-ep7ezoko	87	30	withstand	withstand	VB
cord-316534-ep7ezoko	87	31	challenge	challenge	NN
cord-316534-ep7ezoko	87	32	with	with	IN
cord-316534-ep7ezoko	87	33	SHIV	SHIV	NNP
cord-316534-ep7ezoko	87	34	.	.	.
cord-316534-ep7ezoko	88	1	46	46	CD
cord-316534-ep7ezoko	89	1	Other	other	JJ
cord-316534-ep7ezoko	89	2	attempts	attempt	NNS
cord-316534-ep7ezoko	89	3	to	to	TO
cord-316534-ep7ezoko	89	4	create	create	VB
cord-316534-ep7ezoko	89	5	an	an	DT
cord-316534-ep7ezoko	89	6	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	89	7	vaccine	vaccine	NN
cord-316534-ep7ezoko	89	8	have	have	VBP
cord-316534-ep7ezoko	89	9	focused	focus	VBN
cord-316534-ep7ezoko	89	10	on	on	IN
cord-316534-ep7ezoko	89	11	overcoming	overcome	VBG
cord-316534-ep7ezoko	89	12	the	the	DT
cord-316534-ep7ezoko	89	13	ability	ability	NN
cord-316534-ep7ezoko	89	14	of	of	IN
cord-316534-ep7ezoko	89	15	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	89	16	to	to	TO
cord-316534-ep7ezoko	89	17	escape	escape	VB
cord-316534-ep7ezoko	89	18	immune	immune	JJ
cord-316534-ep7ezoko	89	19	surveillance	surveillance	NN
cord-316534-ep7ezoko	89	20	through	through	IN
cord-316534-ep7ezoko	89	21	use	use	NN
cord-316534-ep7ezoko	89	22	of	of	IN
cord-316534-ep7ezoko	89	23	antibodies	antibody	NNS
cord-316534-ep7ezoko	89	24	that	that	WDT
cord-316534-ep7ezoko	89	25	are	be	VBP
cord-316534-ep7ezoko	89	26	able	able	JJ
cord-316534-ep7ezoko	89	27	to	to	TO
cord-316534-ep7ezoko	89	28	neutralize	neutralize	VB
cord-316534-ep7ezoko	89	29	diverse	diverse	JJ
cord-316534-ep7ezoko	89	30	isolates	isolate	NNS
cord-316534-ep7ezoko	89	31	of	of	IN
cord-316534-ep7ezoko	89	32	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	89	33	.	.	.
cord-316534-ep7ezoko	90	1	These	these	DT
cord-316534-ep7ezoko	90	2	antibodies	antibody	NNS
cord-316534-ep7ezoko	90	3	include	include	VBP
cord-316534-ep7ezoko	90	4	PG9	PG9	NNP
cord-316534-ep7ezoko	90	5	,	,	,
cord-316534-ep7ezoko	90	6	PG16	PG16	NNP
cord-316534-ep7ezoko	90	7	,	,	,
cord-316534-ep7ezoko	90	8	47	47	CD
cord-316534-ep7ezoko	90	9	2F5	2f5	CD
cord-316534-ep7ezoko	90	10	,	,	,
cord-316534-ep7ezoko	90	11	2G12	2g12	CD
cord-316534-ep7ezoko	90	12	,	,	,
cord-316534-ep7ezoko	90	13	4E10	4e10	CD
cord-316534-ep7ezoko	90	14	,	,	,
cord-316534-ep7ezoko	90	15	b12	b12	NN
cord-316534-ep7ezoko	90	16	,	,	,
cord-316534-ep7ezoko	90	17	[	[	-LRB-
cord-316534-ep7ezoko	90	18	48	48	CD
cord-316534-ep7ezoko	90	19	]	]	-RRB-
cord-316534-ep7ezoko	90	20	[	[	-LRB-
cord-316534-ep7ezoko	90	21	49	49	CD
cord-316534-ep7ezoko	90	22	]	]	-RRB-
cord-316534-ep7ezoko	90	23	[	[	-LRB-
cord-316534-ep7ezoko	90	24	50	50	CD
cord-316534-ep7ezoko	90	25	]	]	-RRB-
cord-316534-ep7ezoko	90	26	[	[	-LRB-
cord-316534-ep7ezoko	90	27	51	51	CD
cord-316534-ep7ezoko	90	28	]	]	-RRB-
cord-316534-ep7ezoko	90	29	and	and	CC
cord-316534-ep7ezoko	90	30	most	most	RBS
cord-316534-ep7ezoko	90	31	recently	recently	RB
cord-316534-ep7ezoko	90	32	sCD4	sCD4	NNP
cord-316534-ep7ezoko	90	33	-	-	HYPH
cord-316534-ep7ezoko	90	34	17b	17b	NNS
cord-316534-ep7ezoko	90	35	52	52	CD
cord-316534-ep7ezoko	90	36	and	and	CC
cord-316534-ep7ezoko	90	37	others	other	NNS
cord-316534-ep7ezoko	90	38	.	.	.
cord-316534-ep7ezoko	91	1	53	53	CD
cord-316534-ep7ezoko	91	2	Identification	identification	NN
cord-316534-ep7ezoko	91	3	of	of	IN
cord-316534-ep7ezoko	91	4	these	these	DT
cord-316534-ep7ezoko	91	5	antibodies	antibody	NNS
cord-316534-ep7ezoko	91	6	gives	give	VBZ
cord-316534-ep7ezoko	91	7	hope	hope	NN
cord-316534-ep7ezoko	91	8	that	that	IN
cord-316534-ep7ezoko	91	9	their	-PRON-	PRP$
cord-316534-ep7ezoko	91	10	induction	induction	NN
cord-316534-ep7ezoko	91	11	or	or	CC
cord-316534-ep7ezoko	91	12	the	the	DT
cord-316534-ep7ezoko	91	13	induction	induction	NN
cord-316534-ep7ezoko	91	14	of	of	IN
cord-316534-ep7ezoko	91	15	other	other	JJ
cord-316534-ep7ezoko	91	16	such	such	JJ
cord-316534-ep7ezoko	91	17	broadly	broadly	RB
cord-316534-ep7ezoko	91	18	reactive	reactive	JJ
cord-316534-ep7ezoko	91	19	Nabs	Nabs	NNP
cord-316534-ep7ezoko	91	20	may	may	MD
cord-316534-ep7ezoko	91	21	provide	provide	VB
cord-316534-ep7ezoko	91	22	the	the	DT
cord-316534-ep7ezoko	91	23	basis	basis	NN
cord-316534-ep7ezoko	91	24	for	for	IN
cord-316534-ep7ezoko	91	25	a	a	DT
cord-316534-ep7ezoko	91	26	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	91	27	vaccine	vaccine	NN
cord-316534-ep7ezoko	91	28	in	in	IN
cord-316534-ep7ezoko	91	29	the	the	DT
cord-316534-ep7ezoko	91	30	future	future	NN
cord-316534-ep7ezoko	91	31	.	.	.
cord-316534-ep7ezoko	92	1	The	the	DT
cord-316534-ep7ezoko	92	2	use	use	NN
cord-316534-ep7ezoko	92	3	of	of	IN
cord-316534-ep7ezoko	92	4	animal	animal	NN
cord-316534-ep7ezoko	92	5	models	model	NNS
cord-316534-ep7ezoko	92	6	for	for	IN
cord-316534-ep7ezoko	92	7	development	development	NN
cord-316534-ep7ezoko	92	8	of	of	IN
cord-316534-ep7ezoko	92	9	therapeutics	therapeutic	NNS
cord-316534-ep7ezoko	92	10	offers	offer	VBZ
cord-316534-ep7ezoko	92	11	the	the	DT
cord-316534-ep7ezoko	92	12	benefit	benefit	NN
cord-316534-ep7ezoko	92	13	of	of	IN
cord-316534-ep7ezoko	92	14	thorough	thorough	JJ
cord-316534-ep7ezoko	92	15	testing	testing	NN
cord-316534-ep7ezoko	92	16	and	and	CC
cord-316534-ep7ezoko	92	17	validation	validation	NN
cord-316534-ep7ezoko	92	18	prior	prior	RB
cord-316534-ep7ezoko	92	19	to	to	IN
cord-316534-ep7ezoko	92	20	introduction	introduction	NN
cord-316534-ep7ezoko	92	21	of	of	IN
cord-316534-ep7ezoko	92	22	a	a	DT
cord-316534-ep7ezoko	92	23	vaccine	vaccine	NN
cord-316534-ep7ezoko	92	24	in	in	IN
cord-316534-ep7ezoko	92	25	humans	human	NNS
cord-316534-ep7ezoko	92	26	.	.	.
cord-316534-ep7ezoko	93	1	In	in	IN
cord-316534-ep7ezoko	93	2	the	the	DT
cord-316534-ep7ezoko	93	3	past	past	NN
cord-316534-ep7ezoko	93	4	,	,	,
cord-316534-ep7ezoko	93	5	vaccines	vaccine	NNS
cord-316534-ep7ezoko	93	6	were	be	VBD
cord-316534-ep7ezoko	93	7	made	make	VBN
cord-316534-ep7ezoko	93	8	by	by	IN
cord-316534-ep7ezoko	93	9	observing	observe	VBG
cord-316534-ep7ezoko	93	10	and	and	CC
cord-316534-ep7ezoko	93	11	then	then	RB
cord-316534-ep7ezoko	93	12	mimicking	mimic	VBG
cord-316534-ep7ezoko	93	13	the	the	DT
cord-316534-ep7ezoko	93	14	immune	immune	JJ
cord-316534-ep7ezoko	93	15	response	response	NN
cord-316534-ep7ezoko	93	16	mounted	mount	VBN
cord-316534-ep7ezoko	93	17	by	by	IN
cord-316534-ep7ezoko	93	18	individuals	individual	NNS
cord-316534-ep7ezoko	93	19	who	who	WP
cord-316534-ep7ezoko	93	20	had	have	VBD
cord-316534-ep7ezoko	93	21	recovered	recover	VBN
cord-316534-ep7ezoko	93	22	from	from	IN
cord-316534-ep7ezoko	93	23	a	a	DT
cord-316534-ep7ezoko	93	24	particular	particular	JJ
cord-316534-ep7ezoko	93	25	disease	disease	NN
cord-316534-ep7ezoko	93	26	.	.	.
cord-316534-ep7ezoko	94	1	To	to	IN
cord-316534-ep7ezoko	94	2	date	date	NN
cord-316534-ep7ezoko	94	3	,	,	,
cord-316534-ep7ezoko	94	4	however	however	RB
cord-316534-ep7ezoko	94	5	,	,	,
cord-316534-ep7ezoko	94	6	there	there	EX
cord-316534-ep7ezoko	94	7	are	be	VBP
cord-316534-ep7ezoko	94	8	no	no	DT
cord-316534-ep7ezoko	94	9	known	know	VBN
cord-316534-ep7ezoko	94	10	cases	case	NNS
cord-316534-ep7ezoko	94	11	of	of	IN
cord-316534-ep7ezoko	94	12	individuals	individual	NNS
cord-316534-ep7ezoko	94	13	who	who	WP
cord-316534-ep7ezoko	94	14	have	have	VBP
cord-316534-ep7ezoko	94	15	recovered	recover	VBN
cord-316534-ep7ezoko	94	16	from	from	IN
cord-316534-ep7ezoko	94	17	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	94	18	infection	infection	NN
cord-316534-ep7ezoko	94	19	.	.	.
cord-316534-ep7ezoko	95	1	However	however	RB
cord-316534-ep7ezoko	95	2	,	,	,
cord-316534-ep7ezoko	95	3	data	datum	NNS
cord-316534-ep7ezoko	95	4	can	can	MD
cord-316534-ep7ezoko	95	5	be	be	VB
cord-316534-ep7ezoko	95	6	gathered	gather	VBN
cord-316534-ep7ezoko	95	7	from	from	IN
cord-316534-ep7ezoko	95	8	long	long	JJ
cord-316534-ep7ezoko	95	9	-	-	HYPH
cord-316534-ep7ezoko	95	10	term	term	NN
cord-316534-ep7ezoko	95	11	nonprogressors	nonprogressor	NNS
cord-316534-ep7ezoko	95	12	-patients	-patient	NNS
cord-316534-ep7ezoko	95	13	who	who	WP
cord-316534-ep7ezoko	95	14	have	have	VBP
cord-316534-ep7ezoko	95	15	been	be	VBN
cord-316534-ep7ezoko	95	16	infected	infect	VBN
cord-316534-ep7ezoko	95	17	with	with	IN
cord-316534-ep7ezoko	95	18	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	95	19	for	for	IN
cord-316534-ep7ezoko	95	20	at	at	RB
cord-316534-ep7ezoko	95	21	least	least	JJS
cord-316534-ep7ezoko	95	22	7	7	CD
cord-316534-ep7ezoko	95	23	years	year	NNS
cord-316534-ep7ezoko	95	24	and	and	CC
cord-316534-ep7ezoko	95	25	do	do	VBP
cord-316534-ep7ezoko	95	26	not	not	RB
cord-316534-ep7ezoko	95	27	display	display	VB
cord-316534-ep7ezoko	95	28	any	any	DT
cord-316534-ep7ezoko	95	29	HIV-1-related	hiv-1-relate	VBN
cord-316534-ep7ezoko	95	30	symptoms	symptom	NNS
cord-316534-ep7ezoko	95	31	.	.	.
cord-316534-ep7ezoko	96	1	54	54	CD
cord-316534-ep7ezoko	97	1	,	,	,
cord-316534-ep7ezoko	97	2	55	55	CD
cord-316534-ep7ezoko	98	1	Another	another	DT
cord-316534-ep7ezoko	98	2	option	option	NN
cord-316534-ep7ezoko	98	3	that	that	WDT
cord-316534-ep7ezoko	98	4	may	may	MD
cord-316534-ep7ezoko	98	5	be	be	VB
cord-316534-ep7ezoko	98	6	critical	critical	JJ
cord-316534-ep7ezoko	98	7	to	to	IN
cord-316534-ep7ezoko	98	8	the	the	DT
cord-316534-ep7ezoko	98	9	development	development	NN
cord-316534-ep7ezoko	98	10	of	of	IN
cord-316534-ep7ezoko	98	11	a	a	DT
cord-316534-ep7ezoko	98	12	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	98	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	98	14	is	be	VBZ
cord-316534-ep7ezoko	98	15	the	the	DT
cord-316534-ep7ezoko	98	16	use	use	NN
cord-316534-ep7ezoko	98	17	of	of	IN
cord-316534-ep7ezoko	98	18	relevant	relevant	JJ
cord-316534-ep7ezoko	98	19	animal	animal	NN
cord-316534-ep7ezoko	98	20	models	model	NNS
cord-316534-ep7ezoko	98	21	.	.	.
cord-316534-ep7ezoko	99	1	Such	such	JJ
cord-316534-ep7ezoko	99	2	models	model	NNS
cord-316534-ep7ezoko	99	3	will	will	MD
cord-316534-ep7ezoko	99	4	allow	allow	VB
cord-316534-ep7ezoko	99	5	for	for	IN
cord-316534-ep7ezoko	99	6	analysis	analysis	NN
cord-316534-ep7ezoko	99	7	of	of	IN
cord-316534-ep7ezoko	99	8	the	the	DT
cord-316534-ep7ezoko	99	9	effect	effect	NN
cord-316534-ep7ezoko	99	10	of	of	IN
cord-316534-ep7ezoko	99	11	a	a	DT
cord-316534-ep7ezoko	99	12	potential	potential	JJ
cord-316534-ep7ezoko	99	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	99	14	on	on	IN
cord-316534-ep7ezoko	99	15	an	an	DT
cord-316534-ep7ezoko	99	16	intact	intact	JJ
cord-316534-ep7ezoko	99	17	host	host	NN
cord-316534-ep7ezoko	99	18	prior	prior	RB
cord-316534-ep7ezoko	99	19	to	to	IN
cord-316534-ep7ezoko	99	20	use	use	NN
cord-316534-ep7ezoko	99	21	in	in	IN
cord-316534-ep7ezoko	99	22	humans	human	NNS
cord-316534-ep7ezoko	99	23	.	.	.
cord-316534-ep7ezoko	100	1	One	one	CD
cord-316534-ep7ezoko	100	2	particular	particular	JJ
cord-316534-ep7ezoko	100	3	challenge	challenge	NN
cord-316534-ep7ezoko	100	4	with	with	IN
cord-316534-ep7ezoko	100	5	the	the	DT
cord-316534-ep7ezoko	100	6	use	use	NN
cord-316534-ep7ezoko	100	7	of	of	IN
cord-316534-ep7ezoko	100	8	animal	animal	NN
cord-316534-ep7ezoko	100	9	models	model	NNS
cord-316534-ep7ezoko	100	10	for	for	IN
cord-316534-ep7ezoko	100	11	development	development	NN
cord-316534-ep7ezoko	100	12	of	of	IN
cord-316534-ep7ezoko	100	13	a	a	DT
cord-316534-ep7ezoko	100	14	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	100	15	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	100	16	vaccine	vaccine	NN
cord-316534-ep7ezoko	100	17	is	be	VBZ
cord-316534-ep7ezoko	100	18	that	that	IN
cord-316534-ep7ezoko	100	19	there	there	EX
cord-316534-ep7ezoko	100	20	are	be	VBP
cord-316534-ep7ezoko	100	21	very	very	RB
cord-316534-ep7ezoko	100	22	few	few	JJ
cord-316534-ep7ezoko	100	23	naturally	naturally	RB
cord-316534-ep7ezoko	100	24	occurring	occur	VBG
cord-316534-ep7ezoko	100	25	disease	disease	NN
cord-316534-ep7ezoko	100	26	models	model	NNS
cord-316534-ep7ezoko	100	27	of	of	IN
cord-316534-ep7ezoko	100	28	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	100	29	.	.	.
cord-316534-ep7ezoko	101	1	Only	only	RB
cord-316534-ep7ezoko	101	2	a	a	DT
cord-316534-ep7ezoko	101	3	few	few	JJ
cord-316534-ep7ezoko	101	4	nonhuman	nonhuman	NN
cord-316534-ep7ezoko	101	5	primates	primate	NNS
cord-316534-ep7ezoko	101	6	are	be	VBP
cord-316534-ep7ezoko	101	7	susceptible	susceptible	JJ
cord-316534-ep7ezoko	101	8	to	to	IN
cord-316534-ep7ezoko	101	9	infection	infection	NN
cord-316534-ep7ezoko	101	10	with	with	IN
cord-316534-ep7ezoko	101	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	101	12	and	and	CC
cord-316534-ep7ezoko	101	13	infected	infected	JJ
cord-316534-ep7ezoko	101	14	animals	animal	NNS
cord-316534-ep7ezoko	101	15	do	do	VBP
cord-316534-ep7ezoko	101	16	not	not	RB
cord-316534-ep7ezoko	101	17	progress	progress	VB
cord-316534-ep7ezoko	101	18	to	to	IN
cord-316534-ep7ezoko	101	19	AIDS	AIDS	NNP
cord-316534-ep7ezoko	101	20	.	.	.
cord-316534-ep7ezoko	102	1	56	56	CD
cord-316534-ep7ezoko	103	1	Therefore	therefore	RB
cord-316534-ep7ezoko	103	2	,	,	,
cord-316534-ep7ezoko	103	3	it	-PRON-	PRP
cord-316534-ep7ezoko	103	4	is	be	VBZ
cord-316534-ep7ezoko	103	5	important	important	JJ
cord-316534-ep7ezoko	103	6	to	to	TO
cord-316534-ep7ezoko	103	7	use	use	VB
cord-316534-ep7ezoko	103	8	other	other	JJ
cord-316534-ep7ezoko	103	9	disease	disease	NN
cord-316534-ep7ezoko	103	10	models	model	NNS
cord-316534-ep7ezoko	103	11	that	that	WDT
cord-316534-ep7ezoko	103	12	mimic	mimic	VBP
cord-316534-ep7ezoko	103	13	the	the	DT
cord-316534-ep7ezoko	103	14	HIV	HIV	NNP
cord-316534-ep7ezoko	103	15	-	-	HYPH
cord-316534-ep7ezoko	103	16	AIDS	AIDS	NNP
cord-316534-ep7ezoko	103	17	pathologic	pathologic	JJ
cord-316534-ep7ezoko	103	18	progression	progression	NN
cord-316534-ep7ezoko	103	19	.	.	.
cord-316534-ep7ezoko	104	1	57	57	CD
cord-316534-ep7ezoko	105	1	One	one	CD
cord-316534-ep7ezoko	105	2	such	such	JJ
cord-316534-ep7ezoko	105	3	potential	potential	JJ
cord-316534-ep7ezoko	105	4	model	model	NN
cord-316534-ep7ezoko	105	5	is	be	VBZ
cord-316534-ep7ezoko	105	6	feline	feline	JJ
cord-316534-ep7ezoko	105	7	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	105	8	virus	virus	NN
cord-316534-ep7ezoko	105	9	(	(	-LRB-
cord-316534-ep7ezoko	105	10	FIV	FIV	NNP
cord-316534-ep7ezoko	105	11	)	)	-RRB-
cord-316534-ep7ezoko	105	12	.	.	.
cord-316534-ep7ezoko	106	1	FIV	FIV	NNP
cord-316534-ep7ezoko	106	2	was	be	VBD
cord-316534-ep7ezoko	106	3	discovered	discover	VBN
cord-316534-ep7ezoko	106	4	in	in	IN
cord-316534-ep7ezoko	106	5	1986	1986	CD
cord-316534-ep7ezoko	106	6	and	and	CC
cord-316534-ep7ezoko	106	7	is	be	VBZ
cord-316534-ep7ezoko	106	8	known	know	VBN
cord-316534-ep7ezoko	106	9	to	to	TO
cord-316534-ep7ezoko	106	10	cause	cause	VB
cord-316534-ep7ezoko	106	11	an	an	DT
cord-316534-ep7ezoko	106	12	AIDS	AIDS	NNP
cord-316534-ep7ezoko	106	13	-	-	HYPH
cord-316534-ep7ezoko	106	14	like	like	JJ
cord-316534-ep7ezoko	106	15	disease	disease	NN
cord-316534-ep7ezoko	106	16	in	in	IN
cord-316534-ep7ezoko	106	17	domestic	domestic	JJ
cord-316534-ep7ezoko	106	18	cats	cat	NNS
cord-316534-ep7ezoko	106	19	and	and	CC
cord-316534-ep7ezoko	106	20	mimics	mimic	VBZ
cord-316534-ep7ezoko	106	21	HIV	HIV	NNP
cord-316534-ep7ezoko	106	22	-	-	HYPH
cord-316534-ep7ezoko	106	23	related	relate	VBN
cord-316534-ep7ezoko	106	24	dementia	dementia	NN
cord-316534-ep7ezoko	106	25	in	in	IN
cord-316534-ep7ezoko	106	26	humans	human	NNS
cord-316534-ep7ezoko	106	27	.	.	.
cord-316534-ep7ezoko	107	1	58	58	CD
cord-316534-ep7ezoko	108	1	A	a	DT
cord-316534-ep7ezoko	108	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	108	3	for	for	IN
cord-316534-ep7ezoko	108	4	FIV	FIV	NNP
cord-316534-ep7ezoko	108	5	was	be	VBD
cord-316534-ep7ezoko	108	6	approved	approve	VBN
cord-316534-ep7ezoko	108	7	by	by	IN
cord-316534-ep7ezoko	108	8	the	the	DT
cord-316534-ep7ezoko	108	9	FDA	FDA	NNP
cord-316534-ep7ezoko	108	10	in	in	IN
cord-316534-ep7ezoko	108	11	2002	2002	CD
cord-316534-ep7ezoko	108	12	.	.	.
cord-316534-ep7ezoko	109	1	59	59	CD
cord-316534-ep7ezoko	110	1	While	while	IN
cord-316534-ep7ezoko	110	2	the	the	DT
cord-316534-ep7ezoko	110	3	FIV	FIV	NNP
cord-316534-ep7ezoko	110	4	model	model	NN
cord-316534-ep7ezoko	110	5	is	be	VBZ
cord-316534-ep7ezoko	110	6	potentially	potentially	RB
cord-316534-ep7ezoko	110	7	informative	informative	JJ
cord-316534-ep7ezoko	110	8	,	,	,
cord-316534-ep7ezoko	110	9	its	-PRON-	PRP$
cord-316534-ep7ezoko	110	10	use	use	NN
cord-316534-ep7ezoko	110	11	is	be	VBZ
cord-316534-ep7ezoko	110	12	not	not	RB
cord-316534-ep7ezoko	110	13	sufficient	sufficient	JJ
cord-316534-ep7ezoko	110	14	as	as	IN
cord-316534-ep7ezoko	110	15	a	a	DT
cord-316534-ep7ezoko	110	16	basis	basis	NN
cord-316534-ep7ezoko	110	17	for	for	IN
cord-316534-ep7ezoko	110	18	development	development	NN
cord-316534-ep7ezoko	110	19	of	of	IN
cord-316534-ep7ezoko	110	20	a	a	DT
cord-316534-ep7ezoko	110	21	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	110	22	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	110	23	vaccine	vaccine	NN
cord-316534-ep7ezoko	110	24	.	.	.
cord-316534-ep7ezoko	111	1	An	an	DT
cord-316534-ep7ezoko	111	2	ideal	ideal	JJ
cord-316534-ep7ezoko	111	3	animal	animal	NN
cord-316534-ep7ezoko	111	4	model	model	NN
cord-316534-ep7ezoko	111	5	would	would	MD
cord-316534-ep7ezoko	111	6	display	display	VB
cord-316534-ep7ezoko	111	7	a	a	DT
cord-316534-ep7ezoko	111	8	pathological	pathological	JJ
cord-316534-ep7ezoko	111	9	response	response	NN
cord-316534-ep7ezoko	111	10	to	to	IN
cord-316534-ep7ezoko	111	11	infection	infection	NN
cord-316534-ep7ezoko	111	12	with	with	IN
cord-316534-ep7ezoko	111	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	111	14	that	that	WDT
cord-316534-ep7ezoko	111	15	is	be	VBZ
cord-316534-ep7ezoko	111	16	very	very	RB
cord-316534-ep7ezoko	111	17	similar	similar	JJ
cord-316534-ep7ezoko	111	18	to	to	IN
cord-316534-ep7ezoko	111	19	the	the	DT
cord-316534-ep7ezoko	111	20	one	one	NN
cord-316534-ep7ezoko	111	21	that	that	WDT
cord-316534-ep7ezoko	111	22	occurs	occur	VBZ
cord-316534-ep7ezoko	111	23	in	in	IN
cord-316534-ep7ezoko	111	24	humans	human	NNS
cord-316534-ep7ezoko	111	25	.	.	.
cord-316534-ep7ezoko	112	1	Unfortunately	unfortunately	RB
cord-316534-ep7ezoko	112	2	,	,	,
cord-316534-ep7ezoko	112	3	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	112	4	does	do	VBZ
cord-316534-ep7ezoko	112	5	not	not	RB
cord-316534-ep7ezoko	112	6	cause	cause	VB
cord-316534-ep7ezoko	112	7	pathology	pathology	NN
cord-316534-ep7ezoko	112	8	leading	lead	VBG
cord-316534-ep7ezoko	112	9	to	to	IN
cord-316534-ep7ezoko	112	10	the	the	DT
cord-316534-ep7ezoko	112	11	development	development	NN
cord-316534-ep7ezoko	112	12	of	of	IN
cord-316534-ep7ezoko	112	13	AIDS	AIDS	NNP
cord-316534-ep7ezoko	112	14	in	in	IN
cord-316534-ep7ezoko	112	15	any	any	DT
cord-316534-ep7ezoko	112	16	host	host	NN
cord-316534-ep7ezoko	112	17	other	other	JJ
cord-316534-ep7ezoko	112	18	than	than	IN
cord-316534-ep7ezoko	112	19	humans	human	NNS
cord-316534-ep7ezoko	112	20	.	.	.
cord-316534-ep7ezoko	113	1	[	[	-LRB-
cord-316534-ep7ezoko	113	2	60	60	CD
cord-316534-ep7ezoko	113	3	]	]	-RRB-
cord-316534-ep7ezoko	113	4	[	[	-LRB-
cord-316534-ep7ezoko	113	5	61	61	CD
cord-316534-ep7ezoko	113	6	]	]	-RRB-
cord-316534-ep7ezoko	114	1	[	[	-LRB-
cord-316534-ep7ezoko	114	2	62	62	CD
cord-316534-ep7ezoko	114	3	]	]	-RRB-
cord-316534-ep7ezoko	115	1	[	[	-LRB-
cord-316534-ep7ezoko	115	2	63	63	CD
cord-316534-ep7ezoko	115	3	]	]	-RRB-
cord-316534-ep7ezoko	116	1	However	however	RB
cord-316534-ep7ezoko	116	2	,	,	,
cord-316534-ep7ezoko	116	3	animal	animal	NN
cord-316534-ep7ezoko	116	4	models	model	NNS
cord-316534-ep7ezoko	116	5	have	have	VBP
cord-316534-ep7ezoko	116	6	been	be	VBN
cord-316534-ep7ezoko	116	7	developed	develop	VBN
cord-316534-ep7ezoko	116	8	and	and	CC
cord-316534-ep7ezoko	116	9	used	use	VBN
cord-316534-ep7ezoko	116	10	that	that	WDT
cord-316534-ep7ezoko	116	11	allow	allow	VB
cord-316534-ep7ezoko	116	12	partial	partial	JJ
cord-316534-ep7ezoko	116	13	understanding	understanding	NN
cord-316534-ep7ezoko	116	14	of	of	IN
cord-316534-ep7ezoko	116	15	the	the	DT
cord-316534-ep7ezoko	116	16	pathology	pathology	NN
cord-316534-ep7ezoko	116	17	of	of	IN
cord-316534-ep7ezoko	116	18	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	116	19	,	,	,
cord-316534-ep7ezoko	116	20	the	the	DT
cord-316534-ep7ezoko	116	21	natural	natural	JJ
cord-316534-ep7ezoko	116	22	immunological	immunological	JJ
cord-316534-ep7ezoko	116	23	response	response	NN
cord-316534-ep7ezoko	116	24	to	to	IN
cord-316534-ep7ezoko	116	25	infection	infection	NN
cord-316534-ep7ezoko	116	26	,	,	,
cord-316534-ep7ezoko	116	27	and	and	CC
cord-316534-ep7ezoko	116	28	the	the	DT
cord-316534-ep7ezoko	116	29	response	response	NN
cord-316534-ep7ezoko	116	30	of	of	IN
cord-316534-ep7ezoko	116	31	the	the	DT
cord-316534-ep7ezoko	116	32	host	host	NN
cord-316534-ep7ezoko	116	33	to	to	IN
cord-316534-ep7ezoko	116	34	novel	novel	JJ
cord-316534-ep7ezoko	116	35	therapeutics	therapeutic	NNS
cord-316534-ep7ezoko	116	36	.	.	.
cord-316534-ep7ezoko	117	1	One	one	CD
cord-316534-ep7ezoko	117	2	of	of	IN
cord-316534-ep7ezoko	117	3	these	these	DT
cord-316534-ep7ezoko	117	4	models	model	NNS
cord-316534-ep7ezoko	117	5	involves	involve	VBZ
cord-316534-ep7ezoko	117	6	the	the	DT
cord-316534-ep7ezoko	117	7	simian	simian	JJ
cord-316534-ep7ezoko	117	8	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	117	9	virus	virus	NN
cord-316534-ep7ezoko	117	10	MAC	MAC	NNP
cord-316534-ep7ezoko	117	11	(	(	-LRB-
cord-316534-ep7ezoko	117	12	SIV	SIV	NNP
cord-316534-ep7ezoko	117	13	MAC	MAC	NNP
cord-316534-ep7ezoko	117	14	)	)	-RRB-
cord-316534-ep7ezoko	117	15	that	that	WDT
cord-316534-ep7ezoko	117	16	replicates	replicate	VBZ
cord-316534-ep7ezoko	117	17	and	and	CC
cord-316534-ep7ezoko	117	18	causes	cause	VBZ
cord-316534-ep7ezoko	117	19	an	an	DT
cord-316534-ep7ezoko	117	20	AIDS	AIDS	NNP
cord-316534-ep7ezoko	117	21	-	-	HYPH
cord-316534-ep7ezoko	117	22	like	like	JJ
cord-316534-ep7ezoko	117	23	disease	disease	NN
cord-316534-ep7ezoko	117	24	in	in	IN
cord-316534-ep7ezoko	117	25	baboons	baboon	NNS
cord-316534-ep7ezoko	117	26	,	,	,
cord-316534-ep7ezoko	117	27	cynomolgus	cynomolgus	NNP
cord-316534-ep7ezoko	117	28	,	,	,
cord-316534-ep7ezoko	117	29	and	and	CC
cord-316534-ep7ezoko	117	30	pigtailed	pigtailed	JJ
cord-316534-ep7ezoko	117	31	macaques	macaque	NNS
cord-316534-ep7ezoko	117	32	.	.	.
cord-316534-ep7ezoko	118	1	While	while	IN
cord-316534-ep7ezoko	118	2	the	the	DT
cord-316534-ep7ezoko	118	3	similarities	similarity	NNS
cord-316534-ep7ezoko	118	4	of	of	IN
cord-316534-ep7ezoko	118	5	SIV	SIV	NNP
cord-316534-ep7ezoko	118	6	MAC	MAC	NNP
cord-316534-ep7ezoko	118	7	to	to	IN
cord-316534-ep7ezoko	118	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	118	9	have	have	VBP
cord-316534-ep7ezoko	118	10	allowed	allow	VBN
cord-316534-ep7ezoko	118	11	for	for	IN
cord-316534-ep7ezoko	118	12	insight	insight	NN
cord-316534-ep7ezoko	118	13	into	into	IN
cord-316534-ep7ezoko	118	14	pathology	pathology	NN
cord-316534-ep7ezoko	118	15	,	,	,
cord-316534-ep7ezoko	118	16	transmission	transmission	NN
cord-316534-ep7ezoko	118	17	,	,	,
cord-316534-ep7ezoko	118	18	and	and	CC
cord-316534-ep7ezoko	118	19	immunological	immunological	JJ
cord-316534-ep7ezoko	118	20	response	response	NN
cord-316534-ep7ezoko	118	21	of	of	IN
cord-316534-ep7ezoko	118	22	the	the	DT
cord-316534-ep7ezoko	118	23	infected	infected	JJ
cord-316534-ep7ezoko	118	24	host	host	NN
cord-316534-ep7ezoko	118	25	to	to	IN
cord-316534-ep7ezoko	118	26	the	the	DT
cord-316534-ep7ezoko	118	27	virus	virus	NN
cord-316534-ep7ezoko	118	28	,	,	,
cord-316534-ep7ezoko	118	29	the	the	DT
cord-316534-ep7ezoko	118	30	differences	difference	NNS
cord-316534-ep7ezoko	118	31	between	between	IN
cord-316534-ep7ezoko	118	32	SIV	SIV	NNP
cord-316534-ep7ezoko	118	33	MAC	MAC	NNP
cord-316534-ep7ezoko	118	34	and	and	CC
cord-316534-ep7ezoko	118	35	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	118	36	are	be	VBP
cord-316534-ep7ezoko	118	37	still	still	RB
cord-316534-ep7ezoko	118	38	too	too	RB
cord-316534-ep7ezoko	118	39	great	great	JJ
cord-316534-ep7ezoko	118	40	to	to	TO
cord-316534-ep7ezoko	118	41	be	be	VB
cord-316534-ep7ezoko	118	42	able	able	JJ
cord-316534-ep7ezoko	118	43	to	to	TO
cord-316534-ep7ezoko	118	44	draw	draw	VB
cord-316534-ep7ezoko	118	45	conclusions	conclusion	NNS
cord-316534-ep7ezoko	118	46	regarding	regard	VBG
cord-316534-ep7ezoko	118	47	potential	potential	JJ
cord-316534-ep7ezoko	118	48	human	human	JJ
cord-316534-ep7ezoko	118	49	responses	response	NNS
cord-316534-ep7ezoko	118	50	to	to	IN
cord-316534-ep7ezoko	118	51	an	an	DT
cord-316534-ep7ezoko	118	52	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	118	53	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	118	54	vaccine	vaccine	NN
cord-316534-ep7ezoko	118	55	.	.	.
cord-316534-ep7ezoko	119	1	63	63	CD
cord-316534-ep7ezoko	120	1	Therefore	therefore	RB
cord-316534-ep7ezoko	120	2	,	,	,
cord-316534-ep7ezoko	120	3	to	to	TO
cord-316534-ep7ezoko	120	4	broaden	broaden	VB
cord-316534-ep7ezoko	120	5	the	the	DT
cord-316534-ep7ezoko	120	6	scope	scope	NN
cord-316534-ep7ezoko	120	7	of	of	IN
cord-316534-ep7ezoko	120	8	animal	animal	NN
cord-316534-ep7ezoko	120	9	model	model	NN
cord-316534-ep7ezoko	120	10	usage	usage	NN
cord-316534-ep7ezoko	120	11	,	,	,
cord-316534-ep7ezoko	120	12	a	a	DT
cord-316534-ep7ezoko	120	13	chimeric	chimeric	JJ
cord-316534-ep7ezoko	120	14	SHIV	SHIV	NNP
cord-316534-ep7ezoko	120	15	virus	virus	NN
cord-316534-ep7ezoko	120	16	was	be	VBD
cord-316534-ep7ezoko	120	17	engineered	engineer	VBN
cord-316534-ep7ezoko	120	18	to	to	TO
cord-316534-ep7ezoko	120	19	incorporate	incorporate	VB
cord-316534-ep7ezoko	120	20	both	both	DT
cord-316534-ep7ezoko	120	21	SIV	SIV	NNP
cord-316534-ep7ezoko	120	22	and	and	CC
cord-316534-ep7ezoko	120	23	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	120	24	proteins	protein	NNS
cord-316534-ep7ezoko	120	25	or	or	CC
cord-316534-ep7ezoko	120	26	genes	gene	NNS
cord-316534-ep7ezoko	120	27	.	.	.
cord-316534-ep7ezoko	121	1	64	64	CD
cord-316534-ep7ezoko	122	1	While	while	IN
cord-316534-ep7ezoko	122	2	macaques	macaque	NNS
cord-316534-ep7ezoko	122	3	infected	infect	VBN
cord-316534-ep7ezoko	122	4	with	with	IN
cord-316534-ep7ezoko	122	5	SHIV	SHIV	NNP
cord-316534-ep7ezoko	122	6	do	do	VBP
cord-316534-ep7ezoko	122	7	go	go	VB
cord-316534-ep7ezoko	122	8	on	on	RP
cord-316534-ep7ezoko	122	9	to	to	TO
cord-316534-ep7ezoko	122	10	develop	develop	VB
cord-316534-ep7ezoko	122	11	AIDS	AIDS	NNP
cord-316534-ep7ezoko	122	12	,	,	,
cord-316534-ep7ezoko	122	13	the	the	DT
cord-316534-ep7ezoko	122	14	time	time	NN
cord-316534-ep7ezoko	122	15	to	to	IN
cord-316534-ep7ezoko	122	16	progression	progression	NN
cord-316534-ep7ezoko	122	17	is	be	VBZ
cord-316534-ep7ezoko	122	18	much	much	RB
cord-316534-ep7ezoko	122	19	different	different	JJ
cord-316534-ep7ezoko	122	20	from	from	IN
cord-316534-ep7ezoko	122	21	the	the	DT
cord-316534-ep7ezoko	122	22	time	time	NN
cord-316534-ep7ezoko	122	23	to	to	IN
cord-316534-ep7ezoko	122	24	progression	progression	NN
cord-316534-ep7ezoko	122	25	to	to	IN
cord-316534-ep7ezoko	122	26	AIDS	AIDS	NNP
cord-316534-ep7ezoko	122	27	of	of	IN
cord-316534-ep7ezoko	122	28	HIV-1-infected	hiv-1-infecte	VBN
cord-316534-ep7ezoko	122	29	humans	human	NNS
cord-316534-ep7ezoko	122	30	.	.	.
cord-316534-ep7ezoko	123	1	Infection	infection	NN
cord-316534-ep7ezoko	123	2	of	of	IN
cord-316534-ep7ezoko	123	3	macaques	macaque	NNS
cord-316534-ep7ezoko	123	4	with	with	IN
cord-316534-ep7ezoko	123	5	SIV	SIV	NNP
cord-316534-ep7ezoko	123	6	mac	mac	NNP
cord-316534-ep7ezoko	123	7	251	251	CD
cord-316534-ep7ezoko	123	8	strain	strain	NN
cord-316534-ep7ezoko	123	9	mimics	mimic	VBZ
cord-316534-ep7ezoko	123	10	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	123	11	infection	infection	NN
cord-316534-ep7ezoko	123	12	in	in	IN
cord-316534-ep7ezoko	123	13	humans	human	NNS
cord-316534-ep7ezoko	123	14	by	by	IN
cord-316534-ep7ezoko	123	15	leading	lead	VBG
cord-316534-ep7ezoko	123	16	to	to	IN
cord-316534-ep7ezoko	123	17	chronic	chronic	JJ
cord-316534-ep7ezoko	123	18	,	,	,
cord-316534-ep7ezoko	123	19	slow	slow	JJ
cord-316534-ep7ezoko	123	20	disease	disease	NN
cord-316534-ep7ezoko	123	21	progression	progression	NN
cord-316534-ep7ezoko	123	22	.	.	.
cord-316534-ep7ezoko	124	1	Route	route	NN
cord-316534-ep7ezoko	124	2	and	and	CC
cord-316534-ep7ezoko	124	3	dose	dose	NN
cord-316534-ep7ezoko	124	4	required	require	VBN
cord-316534-ep7ezoko	124	5	for	for	IN
cord-316534-ep7ezoko	124	6	infection	infection	NN
cord-316534-ep7ezoko	124	7	,	,	,
cord-316534-ep7ezoko	124	8	viral	viral	JJ
cord-316534-ep7ezoko	124	9	tropism	tropism	NN
cord-316534-ep7ezoko	124	10	,	,	,
cord-316534-ep7ezoko	124	11	replicative	replicative	JJ
cord-316534-ep7ezoko	124	12	capacity	capacity	NN
cord-316534-ep7ezoko	124	13	of	of	IN
cord-316534-ep7ezoko	124	14	the	the	DT
cord-316534-ep7ezoko	124	15	viruses	virus	NNS
cord-316534-ep7ezoko	124	16	,	,	,
cord-316534-ep7ezoko	124	17	and	and	CC
cord-316534-ep7ezoko	124	18	pathology	pathology	NN
cord-316534-ep7ezoko	124	19	of	of	IN
cord-316534-ep7ezoko	124	20	SIV	SIV	NNP
cord-316534-ep7ezoko	124	21	/	/	SYM
cord-316534-ep7ezoko	124	22	SHIV	SHIV	NNP
cord-316534-ep7ezoko	124	23	-	-	HYPH
cord-316534-ep7ezoko	124	24	infected	infect	VBN
cord-316534-ep7ezoko	124	25	monkeys	monkey	NNS
cord-316534-ep7ezoko	124	26	are	be	VBP
cord-316534-ep7ezoko	124	27	all	all	DT
cord-316534-ep7ezoko	124	28	very	very	RB
cord-316534-ep7ezoko	124	29	different	different	JJ
cord-316534-ep7ezoko	124	30	than	than	IN
cord-316534-ep7ezoko	124	31	these	these	DT
cord-316534-ep7ezoko	124	32	parameters	parameter	NNS
cord-316534-ep7ezoko	124	33	in	in	IN
cord-316534-ep7ezoko	124	34	humans	human	NNS
cord-316534-ep7ezoko	124	35	.	.	.
cord-316534-ep7ezoko	125	1	65	65	CD
cord-316534-ep7ezoko	126	1	,	,	,
cord-316534-ep7ezoko	126	2	66	66	CD
cord-316534-ep7ezoko	127	1	This	this	DT
cord-316534-ep7ezoko	127	2	distinction	distinction	NN
cord-316534-ep7ezoko	127	3	has	have	VBZ
cord-316534-ep7ezoko	127	4	been	be	VBN
cord-316534-ep7ezoko	127	5	well	well	RB
cord-316534-ep7ezoko	127	6	characterized	characterize	VBN
cord-316534-ep7ezoko	127	7	by	by	IN
cord-316534-ep7ezoko	127	8	the	the	DT
cord-316534-ep7ezoko	127	9	recent	recent	JJ
cord-316534-ep7ezoko	127	10	Phase	Phase	NNP
cord-316534-ep7ezoko	127	11	IIb	IIb	NNP
cord-316534-ep7ezoko	127	12	STEP	STEP	NNP
cord-316534-ep7ezoko	127	13	trial	trial	NN
cord-316534-ep7ezoko	127	14	,	,	,
cord-316534-ep7ezoko	127	15	which	which	WDT
cord-316534-ep7ezoko	127	16	involved	involve	VBD
cord-316534-ep7ezoko	127	17	3000	3000	CD
cord-316534-ep7ezoko	127	18	healthy	healthy	JJ
cord-316534-ep7ezoko	127	19	,	,	,
cord-316534-ep7ezoko	127	20	uninfected	uninfected	JJ
cord-316534-ep7ezoko	127	21	volunteers	volunteer	NNS
cord-316534-ep7ezoko	127	22	.	.	.
cord-316534-ep7ezoko	128	1	The	the	DT
cord-316534-ep7ezoko	128	2	result	result	NN
cord-316534-ep7ezoko	128	3	of	of	IN
cord-316534-ep7ezoko	128	4	this	this	DT
cord-316534-ep7ezoko	128	5	trial	trial	NN
cord-316534-ep7ezoko	128	6	was	be	VBD
cord-316534-ep7ezoko	128	7	termination	termination	NN
cord-316534-ep7ezoko	128	8	at	at	IN
cord-316534-ep7ezoko	128	9	its	-PRON-	PRP$
cord-316534-ep7ezoko	128	10	first	first	JJ
cord-316534-ep7ezoko	128	11	scheduled	scheduled	JJ
cord-316534-ep7ezoko	128	12	efficacy	efficacy	NN
cord-316534-ep7ezoko	128	13	assessment	assessment	NN
cord-316534-ep7ezoko	128	14	due	due	IN
cord-316534-ep7ezoko	128	15	to	to	IN
cord-316534-ep7ezoko	128	16	its	-PRON-	PRP$
cord-316534-ep7ezoko	128	17	failure	failure	NN
cord-316534-ep7ezoko	128	18	to	to	TO
cord-316534-ep7ezoko	128	19	suppress	suppress	VB
cord-316534-ep7ezoko	128	20	viral	viral	JJ
cord-316534-ep7ezoko	128	21	load	load	NN
cord-316534-ep7ezoko	128	22	in	in	IN
cord-316534-ep7ezoko	128	23	subsequently	subsequently	RB
cord-316534-ep7ezoko	128	24	infected	infect	VBN
cord-316534-ep7ezoko	128	25	individuals	individual	NNS
cord-316534-ep7ezoko	128	26	and	and	CC
cord-316534-ep7ezoko	128	27	then	then	RB
cord-316534-ep7ezoko	128	28	-	-	HYPH
cord-316534-ep7ezoko	128	29	suspected	suspect	VBN
cord-316534-ep7ezoko	128	30	increased	increase	VBN
cord-316534-ep7ezoko	128	31	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	128	32	infection	infection	NN
cord-316534-ep7ezoko	128	33	due	due	IN
cord-316534-ep7ezoko	128	34	to	to	IN
cord-316534-ep7ezoko	128	35	interaction	interaction	NN
cord-316534-ep7ezoko	128	36	of	of	IN
cord-316534-ep7ezoko	128	37	the	the	DT
cord-316534-ep7ezoko	128	38	immune	immune	JJ
cord-316534-ep7ezoko	128	39	system	system	NN
cord-316534-ep7ezoko	128	40	with	with	IN
cord-316534-ep7ezoko	128	41	vaccine	vaccine	NN
cord-316534-ep7ezoko	128	42	components	component	NNS
cord-316534-ep7ezoko	128	43	.	.	.
cord-316534-ep7ezoko	129	1	67	67	CD
cord-316534-ep7ezoko	130	1	The	the	DT
cord-316534-ep7ezoko	130	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	130	3	,	,	,
cord-316534-ep7ezoko	130	4	a	a	DT
cord-316534-ep7ezoko	130	5	recombinant	recombinant	JJ
cord-316534-ep7ezoko	130	6	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	130	7	serotype	serotype	NN
cord-316534-ep7ezoko	130	8	5	5	CD
cord-316534-ep7ezoko	130	9	(	(	-LRB-
cord-316534-ep7ezoko	130	10	Ad5	Ad5	NNP
cord-316534-ep7ezoko	130	11	)	)	-RRB-
cord-316534-ep7ezoko	130	12	virus	virus	NN
cord-316534-ep7ezoko	130	13	incorporating	incorporate	VBG
cord-316534-ep7ezoko	130	14	the	the	DT
cord-316534-ep7ezoko	130	15	gag	gag	NN
cord-316534-ep7ezoko	130	16	,	,	,
cord-316534-ep7ezoko	130	17	pol	pol	NN
cord-316534-ep7ezoko	130	18	,	,	,
cord-316534-ep7ezoko	130	19	and	and	CC
cord-316534-ep7ezoko	130	20	nef	nef	NNP
cord-316534-ep7ezoko	130	21	genes	gene	NNS
cord-316534-ep7ezoko	130	22	from	from	IN
cord-316534-ep7ezoko	130	23	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	130	24	,	,	,
cord-316534-ep7ezoko	130	25	had	have	VBD
cord-316534-ep7ezoko	130	26	been	be	VBN
cord-316534-ep7ezoko	130	27	previously	previously	RB
cord-316534-ep7ezoko	130	28	tested	test	VBN
cord-316534-ep7ezoko	130	29	in	in	IN
cord-316534-ep7ezoko	130	30	an	an	DT
cord-316534-ep7ezoko	130	31	SHIV	SHIV	NNP
cord-316534-ep7ezoko	130	32	model	model	NN
cord-316534-ep7ezoko	130	33	in	in	IN
cord-316534-ep7ezoko	130	34	macaques	macaque	NNS
cord-316534-ep7ezoko	130	35	and	and	CC
cord-316534-ep7ezoko	130	36	the	the	DT
cord-316534-ep7ezoko	130	37	results	result	NNS
cord-316534-ep7ezoko	130	38	of	of	IN
cord-316534-ep7ezoko	130	39	that	that	DT
cord-316534-ep7ezoko	130	40	experiment	experiment	NN
cord-316534-ep7ezoko	130	41	were	be	VBD
cord-316534-ep7ezoko	130	42	not	not	RB
cord-316534-ep7ezoko	130	43	suggestive	suggestive	JJ
cord-316534-ep7ezoko	130	44	of	of	IN
cord-316534-ep7ezoko	130	45	the	the	DT
cord-316534-ep7ezoko	130	46	results	result	NNS
cord-316534-ep7ezoko	130	47	of	of	IN
cord-316534-ep7ezoko	130	48	the	the	DT
cord-316534-ep7ezoko	130	49	human	human	JJ
cord-316534-ep7ezoko	130	50	trial	trial	NN
cord-316534-ep7ezoko	130	51	.	.	.
cord-316534-ep7ezoko	131	1	68	68	CD
cord-316534-ep7ezoko	132	1	This	this	DT
cord-316534-ep7ezoko	132	2	disparity	disparity	NN
cord-316534-ep7ezoko	132	3	underscores	underscore	VBZ
cord-316534-ep7ezoko	132	4	the	the	DT
cord-316534-ep7ezoko	132	5	need	need	NN
cord-316534-ep7ezoko	132	6	for	for	IN
cord-316534-ep7ezoko	132	7	animal	animal	NN
cord-316534-ep7ezoko	132	8	models	model	NNS
cord-316534-ep7ezoko	132	9	that	that	WDT
cord-316534-ep7ezoko	132	10	more	more	RBR
cord-316534-ep7ezoko	132	11	closely	closely	RB
cord-316534-ep7ezoko	132	12	reflect	reflect	VBP
cord-316534-ep7ezoko	132	13	the	the	DT
cord-316534-ep7ezoko	132	14	pathology	pathology	NN
cord-316534-ep7ezoko	132	15	seen	see	VBN
cord-316534-ep7ezoko	132	16	in	in	IN
cord-316534-ep7ezoko	132	17	human	human	JJ
cord-316534-ep7ezoko	132	18	infection	infection	NN
cord-316534-ep7ezoko	132	19	with	with	IN
cord-316534-ep7ezoko	132	20	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	132	21	as	as	RB
cord-316534-ep7ezoko	132	22	well	well	RB
cord-316534-ep7ezoko	132	23	as	as	IN
cord-316534-ep7ezoko	132	24	identification	identification	NN
cord-316534-ep7ezoko	132	25	of	of	IN
cord-316534-ep7ezoko	132	26	immunological	immunological	JJ
cord-316534-ep7ezoko	132	27	correlates	correlate	NNS
cord-316534-ep7ezoko	132	28	of	of	IN
cord-316534-ep7ezoko	132	29	protection	protection	NN
cord-316534-ep7ezoko	132	30	that	that	WDT
cord-316534-ep7ezoko	132	31	reflect	reflect	VBP
cord-316534-ep7ezoko	132	32	control	control	NN
cord-316534-ep7ezoko	132	33	of	of	IN
cord-316534-ep7ezoko	132	34	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	132	35	viral	viral	JJ
cord-316534-ep7ezoko	132	36	load	load	NN
cord-316534-ep7ezoko	132	37	in	in	IN
cord-316534-ep7ezoko	132	38	human	human	JJ
cord-316534-ep7ezoko	132	39	subjects	subject	NNS
cord-316534-ep7ezoko	132	40	.	.	.
cord-316534-ep7ezoko	133	1	Therefore	therefore	RB
cord-316534-ep7ezoko	133	2	,	,	,
cord-316534-ep7ezoko	133	3	the	the	DT
cord-316534-ep7ezoko	133	4	search	search	NN
cord-316534-ep7ezoko	133	5	for	for	IN
cord-316534-ep7ezoko	133	6	an	an	DT
cord-316534-ep7ezoko	133	7	appropriate	appropriate	JJ
cord-316534-ep7ezoko	133	8	animal	animal	NN
cord-316534-ep7ezoko	133	9	model	model	NN
cord-316534-ep7ezoko	133	10	or	or	CC
cord-316534-ep7ezoko	133	11	the	the	DT
cord-316534-ep7ezoko	133	12	appropriate	appropriate	JJ
cord-316534-ep7ezoko	133	13	use	use	NN
cord-316534-ep7ezoko	133	14	of	of	IN
cord-316534-ep7ezoko	133	15	current	current	JJ
cord-316534-ep7ezoko	133	16	animal	animal	NN
cord-316534-ep7ezoko	133	17	models	model	NNS
cord-316534-ep7ezoko	133	18	in	in	IN
cord-316534-ep7ezoko	133	19	the	the	DT
cord-316534-ep7ezoko	133	20	search	search	NN
cord-316534-ep7ezoko	133	21	for	for	IN
cord-316534-ep7ezoko	133	22	a	a	DT
cord-316534-ep7ezoko	133	23	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	133	24	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	133	25	vaccine	vaccine	NN
cord-316534-ep7ezoko	133	26	continues	continue	VBZ
cord-316534-ep7ezoko	133	27	.	.	.
cord-316534-ep7ezoko	134	1	Until	until	IN
cord-316534-ep7ezoko	134	2	a	a	DT
cord-316534-ep7ezoko	134	3	model	model	NN
cord-316534-ep7ezoko	134	4	can	can	MD
cord-316534-ep7ezoko	134	5	be	be	VB
cord-316534-ep7ezoko	134	6	derived	derive	VBN
cord-316534-ep7ezoko	134	7	that	that	WDT
cord-316534-ep7ezoko	134	8	will	will	MD
cord-316534-ep7ezoko	134	9	allow	allow	VB
cord-316534-ep7ezoko	134	10	for	for	IN
cord-316534-ep7ezoko	134	11	observation	observation	NN
cord-316534-ep7ezoko	134	12	of	of	IN
cord-316534-ep7ezoko	134	13	each	each	DT
cord-316534-ep7ezoko	134	14	stage	stage	NN
cord-316534-ep7ezoko	134	15	of	of	IN
cord-316534-ep7ezoko	134	16	infection	infection	NN
cord-316534-ep7ezoko	134	17	,	,	,
cord-316534-ep7ezoko	134	18	progression	progression	NN
cord-316534-ep7ezoko	134	19	of	of	IN
cord-316534-ep7ezoko	134	20	disease	disease	NN
cord-316534-ep7ezoko	134	21	,	,	,
cord-316534-ep7ezoko	134	22	and	and	CC
cord-316534-ep7ezoko	134	23	response	response	NN
cord-316534-ep7ezoko	134	24	of	of	IN
cord-316534-ep7ezoko	134	25	the	the	DT
cord-316534-ep7ezoko	134	26	immune	immune	JJ
cord-316534-ep7ezoko	134	27	system	system	NN
cord-316534-ep7ezoko	134	28	in	in	IN
cord-316534-ep7ezoko	134	29	a	a	DT
cord-316534-ep7ezoko	134	30	way	way	NN
cord-316534-ep7ezoko	134	31	that	that	WDT
cord-316534-ep7ezoko	134	32	is	be	VBZ
cord-316534-ep7ezoko	134	33	comparable	comparable	JJ
cord-316534-ep7ezoko	134	34	to	to	IN
cord-316534-ep7ezoko	134	35	this	this	DT
cord-316534-ep7ezoko	134	36	process	process	NN
cord-316534-ep7ezoko	134	37	in	in	IN
cord-316534-ep7ezoko	134	38	humans	human	NNS
cord-316534-ep7ezoko	134	39	,	,	,
cord-316534-ep7ezoko	134	40	we	-PRON-	PRP
cord-316534-ep7ezoko	134	41	will	will	MD
cord-316534-ep7ezoko	134	42	not	not	RB
cord-316534-ep7ezoko	134	43	be	be	VB
cord-316534-ep7ezoko	134	44	able	able	JJ
cord-316534-ep7ezoko	134	45	to	to	TO
cord-316534-ep7ezoko	134	46	logically	logically	RB
cord-316534-ep7ezoko	134	47	predict	predict	VB
cord-316534-ep7ezoko	134	48	which	which	WDT
cord-316534-ep7ezoko	134	49	vaccine	vaccine	NN
cord-316534-ep7ezoko	134	50	candidates	candidate	NNS
cord-316534-ep7ezoko	134	51	should	should	MD
cord-316534-ep7ezoko	134	52	be	be	VB
cord-316534-ep7ezoko	134	53	moved	move	VBN
cord-316534-ep7ezoko	134	54	forward	forward	RB
cord-316534-ep7ezoko	134	55	to	to	IN
cord-316534-ep7ezoko	134	56	clinical	clinical	JJ
cord-316534-ep7ezoko	134	57	trials	trial	NNS
cord-316534-ep7ezoko	134	58	.	.	.
cord-316534-ep7ezoko	135	1	Several	several	JJ
cord-316534-ep7ezoko	135	2	attempts	attempt	NNS
cord-316534-ep7ezoko	135	3	to	to	TO
cord-316534-ep7ezoko	135	4	stimulate	stimulate	VB
cord-316534-ep7ezoko	135	5	the	the	DT
cord-316534-ep7ezoko	135	6	immune	immune	JJ
cord-316534-ep7ezoko	135	7	system	system	NN
cord-316534-ep7ezoko	135	8	to	to	TO
cord-316534-ep7ezoko	135	9	provide	provide	VB
cord-316534-ep7ezoko	135	10	protection	protection	NN
cord-316534-ep7ezoko	135	11	against	against	IN
cord-316534-ep7ezoko	135	12	HIV	HIV	NNP
cord-316534-ep7ezoko	135	13	infection	infection	NN
cord-316534-ep7ezoko	135	14	have	have	VBP
cord-316534-ep7ezoko	135	15	been	be	VBN
cord-316534-ep7ezoko	135	16	attempted	attempt	VBN
cord-316534-ep7ezoko	135	17	so	so	RB
cord-316534-ep7ezoko	135	18	far	far	RB
cord-316534-ep7ezoko	135	19	(	(	-LRB-
cord-316534-ep7ezoko	135	20	Table	table	NN
cord-316534-ep7ezoko	135	21	1	1	CD
cord-316534-ep7ezoko	135	22	)	)	-RRB-
cord-316534-ep7ezoko	135	23	.	.	.
cord-316534-ep7ezoko	136	1	Hope	hope	VB
cord-316534-ep7ezoko	136	2	for	for	IN
cord-316534-ep7ezoko	136	3	creating	create	VBG
cord-316534-ep7ezoko	136	4	a	a	DT
cord-316534-ep7ezoko	136	5	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	136	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	136	7	lies	lie	VBZ
cord-316534-ep7ezoko	136	8	in	in	IN
cord-316534-ep7ezoko	136	9	the	the	DT
cord-316534-ep7ezoko	136	10	ability	ability	NN
cord-316534-ep7ezoko	136	11	of	of	IN
cord-316534-ep7ezoko	136	12	the	the	DT
cord-316534-ep7ezoko	136	13	scientific	scientific	JJ
cord-316534-ep7ezoko	136	14	community	community	NN
cord-316534-ep7ezoko	136	15	to	to	TO
cord-316534-ep7ezoko	136	16	identify	identify	VB
cord-316534-ep7ezoko	136	17	and	and	CC
cord-316534-ep7ezoko	136	18	induce	induce	VB
cord-316534-ep7ezoko	136	19	a	a	DT
cord-316534-ep7ezoko	136	20	broad	broad	JJ
cord-316534-ep7ezoko	136	21	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	136	22	antibody	antibody	NN
cord-316534-ep7ezoko	136	23	response	response	NN
cord-316534-ep7ezoko	136	24	that	that	WDT
cord-316534-ep7ezoko	136	25	would	would	MD
cord-316534-ep7ezoko	136	26	offer	offer	VB
cord-316534-ep7ezoko	136	27	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	136	28	immunity	immunity	NN
cord-316534-ep7ezoko	136	29	to	to	IN
cord-316534-ep7ezoko	136	30	vaccinated	vaccinated	JJ
cord-316534-ep7ezoko	136	31	patients	patient	NNS
cord-316534-ep7ezoko	136	32	.	.	.
cord-316534-ep7ezoko	137	1	To	to	IN
cord-316534-ep7ezoko	137	2	this	this	DT
cord-316534-ep7ezoko	137	3	end	end	NN
cord-316534-ep7ezoko	137	4	,	,	,
cord-316534-ep7ezoko	137	5	several	several	JJ
cord-316534-ep7ezoko	137	6	novel	novel	NN
cord-316534-ep7ezoko	137	7	approaches	approach	NNS
cord-316534-ep7ezoko	137	8	are	be	VBP
cord-316534-ep7ezoko	137	9	being	be	VBG
cord-316534-ep7ezoko	137	10	studied	study	VBN
cord-316534-ep7ezoko	137	11	.	.	.
cord-316534-ep7ezoko	138	1	As	as	IN
cord-316534-ep7ezoko	138	2	mentioned	mention	VBN
cord-316534-ep7ezoko	138	3	in	in	IN
cord-316534-ep7ezoko	138	4	the	the	DT
cord-316534-ep7ezoko	138	5	previous	previous	JJ
cord-316534-ep7ezoko	138	6	section	section	NN
cord-316534-ep7ezoko	138	7	,	,	,
cord-316534-ep7ezoko	138	8	there	there	EX
cord-316534-ep7ezoko	138	9	are	be	VBP
cord-316534-ep7ezoko	138	10	several	several	JJ
cord-316534-ep7ezoko	138	11	daunting	daunting	JJ
cord-316534-ep7ezoko	138	12	problems	problem	NNS
cord-316534-ep7ezoko	138	13	facing	face	VBG
cord-316534-ep7ezoko	138	14	scientists	scientist	NNS
cord-316534-ep7ezoko	138	15	who	who	WP
cord-316534-ep7ezoko	138	16	are	be	VBP
cord-316534-ep7ezoko	138	17	attempting	attempt	VBG
cord-316534-ep7ezoko	138	18	to	to	TO
cord-316534-ep7ezoko	138	19	create	create	VB
cord-316534-ep7ezoko	138	20	an	an	DT
cord-316534-ep7ezoko	138	21	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	138	22	vaccine	vaccine	NN
cord-316534-ep7ezoko	138	23	.	.	.
cord-316534-ep7ezoko	139	1	In	in	IN
cord-316534-ep7ezoko	139	2	hopes	hope	NNS
cord-316534-ep7ezoko	139	3	of	of	IN
cord-316534-ep7ezoko	139	4	creating	create	VBG
cord-316534-ep7ezoko	139	5	a	a	DT
cord-316534-ep7ezoko	139	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	139	7	which	which	WDT
cord-316534-ep7ezoko	139	8	elicits	elicit	VBZ
cord-316534-ep7ezoko	139	9	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	139	10	immunity	immunity	NN
cord-316534-ep7ezoko	139	11	to	to	IN
cord-316534-ep7ezoko	139	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	139	13	,	,	,
cord-316534-ep7ezoko	139	14	researchers	researcher	NNS
cord-316534-ep7ezoko	139	15	have	have	VBP
cord-316534-ep7ezoko	139	16	focused	focus	VBN
cord-316534-ep7ezoko	139	17	their	-PRON-	PRP$
cord-316534-ep7ezoko	139	18	efforts	effort	NNS
cord-316534-ep7ezoko	139	19	on	on	IN
cord-316534-ep7ezoko	139	20	(	(	-LRB-
cord-316534-ep7ezoko	139	21	1	1	LS
cord-316534-ep7ezoko	139	22	)	)	-RRB-
cord-316534-ep7ezoko	139	23	the	the	DT
cord-316534-ep7ezoko	139	24	use	use	NN
cord-316534-ep7ezoko	139	25	of	of	IN
cord-316534-ep7ezoko	139	26	plasmid	plasmid	NN
cord-316534-ep7ezoko	139	27	DNA	dna	NN
cord-316534-ep7ezoko	139	28	vaccines	vaccine	NNS
cord-316534-ep7ezoko	139	29	,	,	,
cord-316534-ep7ezoko	139	30	(	(	-LRB-
cord-316534-ep7ezoko	139	31	2	2	LS
cord-316534-ep7ezoko	139	32	)	)	-RRB-
cord-316534-ep7ezoko	139	33	live	live	JJ
cord-316534-ep7ezoko	139	34	recombinant	recombinant	JJ
cord-316534-ep7ezoko	139	35	vectors	vector	NNS
cord-316534-ep7ezoko	139	36	for	for	IN
cord-316534-ep7ezoko	139	37	vaccine	vaccine	NN
cord-316534-ep7ezoko	139	38	development	development	NN
cord-316534-ep7ezoko	139	39	(	(	-LRB-
cord-316534-ep7ezoko	139	40	expressing	express	VBG
cord-316534-ep7ezoko	139	41	or	or	CC
cord-316534-ep7ezoko	139	42	presenting	present	VBG
cord-316534-ep7ezoko	139	43	HIV	HIV	NNP
cord-316534-ep7ezoko	139	44	antigens	antigen	NNS
cord-316534-ep7ezoko	139	45	)	)	-RRB-
cord-316534-ep7ezoko	139	46	,	,	,
cord-316534-ep7ezoko	139	47	and	and	CC
cord-316534-ep7ezoko	139	48	(	(	-LRB-
cord-316534-ep7ezoko	139	49	3	3	LS
cord-316534-ep7ezoko	139	50	)	)	-RRB-
cord-316534-ep7ezoko	139	51	mucosal	mucosal	JJ
cord-316534-ep7ezoko	139	52	immunity	immunity	NN
cord-316534-ep7ezoko	139	53	.	.	.
cord-316534-ep7ezoko	140	1	These	these	DT
cord-316534-ep7ezoko	140	2	critical	critical	JJ
cord-316534-ep7ezoko	140	3	topics	topic	NNS
cord-316534-ep7ezoko	140	4	will	will	MD
cord-316534-ep7ezoko	140	5	be	be	VB
cord-316534-ep7ezoko	140	6	discussed	discuss	VBN
cord-316534-ep7ezoko	140	7	in	in	IN
cord-316534-ep7ezoko	140	8	more	more	JJR
cord-316534-ep7ezoko	140	9	detail	detail	NN
cord-316534-ep7ezoko	140	10	below	below	RB
cord-316534-ep7ezoko	140	11	.	.	.
cord-316534-ep7ezoko	141	1	Vaccines	vaccine	NNS
cord-316534-ep7ezoko	141	2	should	should	MD
cord-316534-ep7ezoko	141	3	elicit	elicit	VB
cord-316534-ep7ezoko	141	4	a	a	DT
cord-316534-ep7ezoko	141	5	robust	robust	JJ
cord-316534-ep7ezoko	141	6	immune	immune	JJ
cord-316534-ep7ezoko	141	7	response	response	NN
cord-316534-ep7ezoko	141	8	that	that	WDT
cord-316534-ep7ezoko	141	9	is	be	VBZ
cord-316534-ep7ezoko	141	10	long	long	RB
cord-316534-ep7ezoko	141	11	lasting	last	VBG
cord-316534-ep7ezoko	141	12	and	and	CC
cord-316534-ep7ezoko	141	13	is	be	VBZ
cord-316534-ep7ezoko	141	14	able	able	JJ
cord-316534-ep7ezoko	141	15	to	to	TO
cord-316534-ep7ezoko	141	16	provide	provide	VB
cord-316534-ep7ezoko	141	17	protection	protection	NN
cord-316534-ep7ezoko	141	18	against	against	IN
cord-316534-ep7ezoko	141	19	various	various	JJ
cord-316534-ep7ezoko	141	20	strains	strain	NNS
cord-316534-ep7ezoko	141	21	of	of	IN
cord-316534-ep7ezoko	141	22	a	a	DT
cord-316534-ep7ezoko	141	23	pathogen	pathogen	NN
cord-316534-ep7ezoko	141	24	.	.	.
cord-316534-ep7ezoko	142	1	Plasmid	Plasmid	NNP
cord-316534-ep7ezoko	142	2	DNA	DNA	NNP
cord-316534-ep7ezoko	142	3	vaccinations	vaccination	NNS
cord-316534-ep7ezoko	142	4	can	can	MD
cord-316534-ep7ezoko	142	5	induce	induce	VB
cord-316534-ep7ezoko	142	6	a	a	DT
cord-316534-ep7ezoko	142	7	strong	strong	JJ
cord-316534-ep7ezoko	142	8	humoral	humoral	JJ
cord-316534-ep7ezoko	142	9	and	and	CC
cord-316534-ep7ezoko	142	10	T	t	NN
cord-316534-ep7ezoko	142	11	-	-	HYPH
cord-316534-ep7ezoko	142	12	cell	cell	NN
cord-316534-ep7ezoko	142	13	response	response	NN
cord-316534-ep7ezoko	142	14	.	.	.
cord-316534-ep7ezoko	143	1	DNA	dna	NN
cord-316534-ep7ezoko	143	2	-	-	HYPH
cord-316534-ep7ezoko	143	3	based	base	VBN
cord-316534-ep7ezoko	143	4	vaccination	vaccination	NN
cord-316534-ep7ezoko	143	5	has	have	VBZ
cord-316534-ep7ezoko	143	6	been	be	VBN
cord-316534-ep7ezoko	143	7	used	use	VBN
cord-316534-ep7ezoko	143	8	as	as	IN
cord-316534-ep7ezoko	143	9	a	a	DT
cord-316534-ep7ezoko	143	10	powerful	powerful	JJ
cord-316534-ep7ezoko	143	11	tool	tool	NN
cord-316534-ep7ezoko	143	12	to	to	TO
cord-316534-ep7ezoko	143	13	fight	fight	VB
cord-316534-ep7ezoko	143	14	against	against	IN
cord-316534-ep7ezoko	143	15	parasitic	parasitic	JJ
cord-316534-ep7ezoko	143	16	,	,	,
cord-316534-ep7ezoko	143	17	fungal	fungal	JJ
cord-316534-ep7ezoko	143	18	,	,	,
cord-316534-ep7ezoko	143	19	bacterial	bacterial	JJ
cord-316534-ep7ezoko	143	20	,	,	,
cord-316534-ep7ezoko	143	21	and	and	CC
cord-316534-ep7ezoko	143	22	viral	viral	JJ
cord-316534-ep7ezoko	143	23	infections	infection	NNS
cord-316534-ep7ezoko	143	24	.	.	.
cord-316534-ep7ezoko	144	1	[	[	-LRB-
cord-316534-ep7ezoko	144	2	115	115	CD
cord-316534-ep7ezoko	144	3	]	]	-RRB-
cord-316534-ep7ezoko	144	4	[	[	-LRB-
cord-316534-ep7ezoko	144	5	116	116	CD
cord-316534-ep7ezoko	144	6	]	]	-RRB-
cord-316534-ep7ezoko	144	7	[	[	-LRB-
cord-316534-ep7ezoko	144	8	117	117	CD
cord-316534-ep7ezoko	144	9	]	]	-RRB-
cord-316534-ep7ezoko	144	10	[	[	-LRB-
cord-316534-ep7ezoko	144	11	118	118	CD
cord-316534-ep7ezoko	144	12	]	]	-RRB-
cord-316534-ep7ezoko	144	13	[	[	-LRB-
cord-316534-ep7ezoko	144	14	119	119	CD
cord-316534-ep7ezoko	144	15	]	]	-RRB-
cord-316534-ep7ezoko	145	1	There	there	EX
cord-316534-ep7ezoko	145	2	are	be	VBP
cord-316534-ep7ezoko	145	3	multiple	multiple	JJ
cord-316534-ep7ezoko	145	4	advantages	advantage	NNS
cord-316534-ep7ezoko	145	5	for	for	IN
cord-316534-ep7ezoko	145	6	using	use	VBG
cord-316534-ep7ezoko	145	7	plasmid	plasmid	NN
cord-316534-ep7ezoko	145	8	DNA	dna	NN
cord-316534-ep7ezoko	145	9	for	for	IN
cord-316534-ep7ezoko	145	10	vaccination	vaccination	NN
cord-316534-ep7ezoko	145	11	:	:	:
cord-316534-ep7ezoko	145	12	they	-PRON-	PRP
cord-316534-ep7ezoko	145	13	are	be	VBP
cord-316534-ep7ezoko	145	14	generally	generally	RB
cord-316534-ep7ezoko	145	15	safe	safe	JJ
cord-316534-ep7ezoko	145	16	,	,	,
cord-316534-ep7ezoko	145	17	nontoxic	nontoxic	JJ
cord-316534-ep7ezoko	145	18	,	,	,
cord-316534-ep7ezoko	145	19	and	and	CC
cord-316534-ep7ezoko	145	20	through	through	IN
cord-316534-ep7ezoko	145	21	the	the	DT
cord-316534-ep7ezoko	145	22	delivery	delivery	NN
cord-316534-ep7ezoko	145	23	of	of	IN
cord-316534-ep7ezoko	145	24	a	a	DT
cord-316534-ep7ezoko	145	25	gene	gene	NN
cord-316534-ep7ezoko	145	26	encoding	encode	VBG
cord-316534-ep7ezoko	145	27	important	important	JJ
cord-316534-ep7ezoko	145	28	immunogenic	immunogenic	JJ
cord-316534-ep7ezoko	145	29	epitopes	epitope	NNS
cord-316534-ep7ezoko	145	30	,	,	,
cord-316534-ep7ezoko	145	31	the	the	DT
cord-316534-ep7ezoko	145	32	DNAbased	dnabased	JJ
cord-316534-ep7ezoko	145	33	vaccine	vaccine	NN
cord-316534-ep7ezoko	145	34	exploits	exploit	VBZ
cord-316534-ep7ezoko	145	35	biosynthetic	biosynthetic	JJ
cord-316534-ep7ezoko	145	36	machinery	machinery	NN
cord-316534-ep7ezoko	145	37	of	of	IN
cord-316534-ep7ezoko	145	38	the	the	DT
cord-316534-ep7ezoko	145	39	host	host	NN
cord-316534-ep7ezoko	145	40	cell	cell	NN
cord-316534-ep7ezoko	145	41	.	.	.
cord-316534-ep7ezoko	146	1	One	one	CD
cord-316534-ep7ezoko	146	2	such	such	JJ
cord-316534-ep7ezoko	146	3	example	example	NN
cord-316534-ep7ezoko	146	4	was	be	VBD
cord-316534-ep7ezoko	146	5	in	in	IN
cord-316534-ep7ezoko	146	6	1990	1990	CD
cord-316534-ep7ezoko	146	7	,	,	,
cord-316534-ep7ezoko	146	8	whereby	whereby	WRB
cord-316534-ep7ezoko	146	9	Wolff	Wolff	NNP
cord-316534-ep7ezoko	146	10	and	and	CC
cord-316534-ep7ezoko	146	11	colleagues	colleague	NNS
cord-316534-ep7ezoko	146	12	illustrated	illustrate	VBD
cord-316534-ep7ezoko	146	13	protein	protein	NN
cord-316534-ep7ezoko	146	14	expression	expression	NN
cord-316534-ep7ezoko	146	15	after	after	IN
cord-316534-ep7ezoko	146	16	intramuscular	intramuscular	JJ
cord-316534-ep7ezoko	146	17	(	(	-LRB-
cord-316534-ep7ezoko	146	18	IM	im	NN
cord-316534-ep7ezoko	146	19	)	)	-RRB-
cord-316534-ep7ezoko	146	20	injection	injection	NN
cord-316534-ep7ezoko	146	21	of	of	IN
cord-316534-ep7ezoko	146	22	plasmid	plasmid	NN
cord-316534-ep7ezoko	146	23	DNA	dna	NN
cord-316534-ep7ezoko	146	24	into	into	IN
cord-316534-ep7ezoko	146	25	myocytes	myocyte	NNS
cord-316534-ep7ezoko	146	26	.	.	.
cord-316534-ep7ezoko	147	1	120	120	CD
cord-316534-ep7ezoko	148	1	Despite	despite	IN
cord-316534-ep7ezoko	148	2	these	these	DT
cord-316534-ep7ezoko	148	3	promising	promising	JJ
cord-316534-ep7ezoko	148	4	results	result	NNS
cord-316534-ep7ezoko	148	5	,	,	,
cord-316534-ep7ezoko	148	6	there	there	EX
cord-316534-ep7ezoko	148	7	had	have	VBD
cord-316534-ep7ezoko	148	8	been	be	VBN
cord-316534-ep7ezoko	148	9	speculation	speculation	NN
cord-316534-ep7ezoko	148	10	regarding	regard	VBG
cord-316534-ep7ezoko	148	11	DNA	dna	NN
cord-316534-ep7ezoko	148	12	vaccination	vaccination	NN
cord-316534-ep7ezoko	148	13	strategies	strategy	NNS
cord-316534-ep7ezoko	148	14	.	.	.
cord-316534-ep7ezoko	149	1	For	for	IN
cord-316534-ep7ezoko	149	2	example	example	NN
cord-316534-ep7ezoko	149	3	,	,	,
cord-316534-ep7ezoko	149	4	it	-PRON-	PRP
cord-316534-ep7ezoko	149	5	was	be	VBD
cord-316534-ep7ezoko	149	6	shown	show	VBN
cord-316534-ep7ezoko	149	7	that	that	IN
cord-316534-ep7ezoko	149	8	protein	protein	NN
cord-316534-ep7ezoko	149	9	production	production	NN
cord-316534-ep7ezoko	149	10	in	in	IN
cord-316534-ep7ezoko	149	11	response	response	NN
cord-316534-ep7ezoko	149	12	to	to	IN
cord-316534-ep7ezoko	149	13	DNA	dna	NN
cord-316534-ep7ezoko	149	14	plasmids	plasmid	NNS
cord-316534-ep7ezoko	149	15	that	that	WDT
cord-316534-ep7ezoko	149	16	contained	contain	VBD
cord-316534-ep7ezoko	149	17	HIV	HIV	NNP
cord-316534-ep7ezoko	149	18	inserts	insert	NNS
cord-316534-ep7ezoko	149	19	elicited	elicit	VBD
cord-316534-ep7ezoko	149	20	substantial	substantial	JJ
cord-316534-ep7ezoko	149	21	cellular	cellular	JJ
cord-316534-ep7ezoko	149	22	response	response	NN
cord-316534-ep7ezoko	149	23	in	in	IN
cord-316534-ep7ezoko	149	24	mice	mouse	NNS
cord-316534-ep7ezoko	149	25	and	and	CC
cord-316534-ep7ezoko	149	26	nonhuman	nonhuman	NN
cord-316534-ep7ezoko	149	27	primates	primate	NNS
cord-316534-ep7ezoko	149	28	.	.	.
cord-316534-ep7ezoko	150	1	However	however	RB
cord-316534-ep7ezoko	150	2	,	,	,
cord-316534-ep7ezoko	150	3	these	these	DT
cord-316534-ep7ezoko	150	4	products	product	NNS
cord-316534-ep7ezoko	150	5	were	be	VBD
cord-316534-ep7ezoko	150	6	poorly	poorly	RB
cord-316534-ep7ezoko	150	7	immunogenic	immunogenic	JJ
cord-316534-ep7ezoko	150	8	in	in	IN
cord-316534-ep7ezoko	150	9	humans	human	NNS
cord-316534-ep7ezoko	150	10	.	.	.
cord-316534-ep7ezoko	151	1	One	one	CD
cord-316534-ep7ezoko	151	2	strategy	strategy	NN
cord-316534-ep7ezoko	151	3	to	to	TO
cord-316534-ep7ezoko	151	4	improve	improve	VB
cord-316534-ep7ezoko	151	5	immune	immune	JJ
cord-316534-ep7ezoko	151	6	response	response	NN
cord-316534-ep7ezoko	151	7	of	of	IN
cord-316534-ep7ezoko	151	8	the	the	DT
cord-316534-ep7ezoko	151	9	plasmid	plasmid	NN
cord-316534-ep7ezoko	151	10	DNA	dna	NN
cord-316534-ep7ezoko	151	11	vaccine	vaccine	NN
cord-316534-ep7ezoko	151	12	strategy	strategy	NN
cord-316534-ep7ezoko	151	13	is	be	VBZ
cord-316534-ep7ezoko	151	14	by	by	IN
cord-316534-ep7ezoko	151	15	coadministration	coadministration	NN
cord-316534-ep7ezoko	151	16	of	of	IN
cord-316534-ep7ezoko	151	17	DNA	DNA	NNP
cord-316534-ep7ezoko	151	18	plasmids	plasmid	NNS
cord-316534-ep7ezoko	151	19	coding	code	VBG
cord-316534-ep7ezoko	151	20	for	for	IN
cord-316534-ep7ezoko	151	21	cytokines	cytokine	NNS
cord-316534-ep7ezoko	151	22	(	(	-LRB-
cord-316534-ep7ezoko	151	23	eg	eg	IN
cord-316534-ep7ezoko	151	24	,	,	,
cord-316534-ep7ezoko	151	25	INF	INF	NNP
cord-316534-ep7ezoko	151	26	-	-	HYPH
cord-316534-ep7ezoko	151	27	g	g	NNP
cord-316534-ep7ezoko	151	28	,	,	,
cord-316534-ep7ezoko	151	29	IL-2	il-2	NN
cord-316534-ep7ezoko	151	30	,	,	,
cord-316534-ep7ezoko	151	31	IL-12	IL-12	NNP
cord-316534-ep7ezoko	151	32	,	,	,
cord-316534-ep7ezoko	151	33	IL-18	IL-18	NNP
cord-316534-ep7ezoko	151	34	,	,	,
cord-316534-ep7ezoko	151	35	and	and	CC
cord-316534-ep7ezoko	151	36	IL-15	IL-15	NNP
cord-316534-ep7ezoko	151	37	)	)	-RRB-
cord-316534-ep7ezoko	151	38	.	.	.
cord-316534-ep7ezoko	152	1	[	[	-LRB-
cord-316534-ep7ezoko	152	2	121	121	CD
cord-316534-ep7ezoko	152	3	]	]	-RRB-
cord-316534-ep7ezoko	152	4	[	[	-LRB-
cord-316534-ep7ezoko	152	5	122	122	CD
cord-316534-ep7ezoko	152	6	]	]	-RRB-
cord-316534-ep7ezoko	152	7	[	[	-LRB-
cord-316534-ep7ezoko	152	8	123	123	CD
cord-316534-ep7ezoko	152	9	]	]	-RRB-
cord-316534-ep7ezoko	153	1	[	[	-LRB-
cord-316534-ep7ezoko	153	2	124	124	CD
cord-316534-ep7ezoko	153	3	]	]	-RRB-
cord-316534-ep7ezoko	154	1	A	a	DT
cord-316534-ep7ezoko	154	2	second	second	JJ
cord-316534-ep7ezoko	154	3	strategy	strategy	NN
cord-316534-ep7ezoko	154	4	which	which	WDT
cord-316534-ep7ezoko	154	5	has	have	VBZ
cord-316534-ep7ezoko	154	6	been	be	VBN
cord-316534-ep7ezoko	154	7	utilized	utilize	VBN
cord-316534-ep7ezoko	154	8	to	to	TO
cord-316534-ep7ezoko	154	9	improve	improve	VB
cord-316534-ep7ezoko	154	10	plasmid	plasmid	NN
cord-316534-ep7ezoko	154	11	DNA	dna	NN
cord-316534-ep7ezoko	154	12	vaccination	vaccination	NN
cord-316534-ep7ezoko	154	13	has	have	VBZ
cord-316534-ep7ezoko	154	14	been	be	VBN
cord-316534-ep7ezoko	154	15	the	the	DT
cord-316534-ep7ezoko	154	16	administration	administration	NN
cord-316534-ep7ezoko	154	17	of	of	IN
cord-316534-ep7ezoko	154	18	plasmid	plasmid	NNP
cord-316534-ep7ezoko	154	19	DNA	DNA	NNP
cord-316534-ep7ezoko	154	20	with	with	IN
cord-316534-ep7ezoko	154	21	adjuvants	adjuvant	NNS
cord-316534-ep7ezoko	154	22	(	(	-LRB-
cord-316534-ep7ezoko	154	23	eg	eg	UH
cord-316534-ep7ezoko	154	24	,	,	,
cord-316534-ep7ezoko	154	25	CpG	CpG	NNP
cord-316534-ep7ezoko	154	26	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-316534-ep7ezoko	154	27	)	)	-RRB-
cord-316534-ep7ezoko	154	28	,	,	,
cord-316534-ep7ezoko	154	29	or	or	CC
cord-316534-ep7ezoko	154	30	the	the	DT
cord-316534-ep7ezoko	154	31	use	use	NN
cord-316534-ep7ezoko	154	32	of	of	IN
cord-316534-ep7ezoko	154	33	DNA	dna	NN
cord-316534-ep7ezoko	154	34	-	-	HYPH
cord-316534-ep7ezoko	154	35	delivery	delivery	NN
cord-316534-ep7ezoko	154	36	systems	system	NNS
cord-316534-ep7ezoko	154	37	(	(	-LRB-
cord-316534-ep7ezoko	154	38	eg	eg	IN
cord-316534-ep7ezoko	154	39	,	,	,
cord-316534-ep7ezoko	154	40	microparticles	microparticle	NNS
cord-316534-ep7ezoko	154	41	,	,	,
cord-316534-ep7ezoko	154	42	cochleates	cochleate	NNS
cord-316534-ep7ezoko	154	43	,	,	,
cord-316534-ep7ezoko	154	44	and	and	CC
cord-316534-ep7ezoko	154	45	linear	linear	JJ
cord-316534-ep7ezoko	154	46	polyenimines	polyenimine	NNS
cord-316534-ep7ezoko	154	47	)	)	-RRB-
cord-316534-ep7ezoko	154	48	.	.	.
cord-316534-ep7ezoko	155	1	[	[	-LRB-
cord-316534-ep7ezoko	155	2	125	125	CD
cord-316534-ep7ezoko	155	3	]	]	-RRB-
cord-316534-ep7ezoko	155	4	[	[	-LRB-
cord-316534-ep7ezoko	155	5	126	126	CD
cord-316534-ep7ezoko	155	6	]	]	-RRB-
cord-316534-ep7ezoko	155	7	[	[	-LRB-
cord-316534-ep7ezoko	155	8	127	127	CD
cord-316534-ep7ezoko	155	9	]	]	-RRB-
cord-316534-ep7ezoko	156	1	[	[	-LRB-
cord-316534-ep7ezoko	156	2	128	128	CD
cord-316534-ep7ezoko	156	3	]	]	-RRB-
cord-316534-ep7ezoko	157	1	A	a	DT
cord-316534-ep7ezoko	157	2	third	third	JJ
cord-316534-ep7ezoko	157	3	strategy	strategy	NN
cord-316534-ep7ezoko	157	4	to	to	TO
cord-316534-ep7ezoko	157	5	improve	improve	VB
cord-316534-ep7ezoko	157	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	157	7	efficacy	efficacy	NN
cord-316534-ep7ezoko	157	8	involves	involve	VBZ
cord-316534-ep7ezoko	157	9	the	the	DT
cord-316534-ep7ezoko	157	10	coadministration	coadministration	NN
cord-316534-ep7ezoko	157	11	of	of	IN
cord-316534-ep7ezoko	157	12	plasmid	plasmid	NNP
cord-316534-ep7ezoko	157	13	DNA	DNA	NNP
cord-316534-ep7ezoko	157	14	in	in	IN
cord-316534-ep7ezoko	157	15	combination	combination	NN
cord-316534-ep7ezoko	157	16	with	with	IN
cord-316534-ep7ezoko	157	17	viral	viral	JJ
cord-316534-ep7ezoko	157	18	vectors	vector	NNS
cord-316534-ep7ezoko	157	19	.	.	.
cord-316534-ep7ezoko	158	1	For	for	IN
cord-316534-ep7ezoko	158	2	instance	instance	NN
cord-316534-ep7ezoko	158	3	,	,	,
cord-316534-ep7ezoko	158	4	research	research	NN
cord-316534-ep7ezoko	158	5	performed	perform	VBN
cord-316534-ep7ezoko	158	6	by	by	IN
cord-316534-ep7ezoko	158	7	Harari	Harari	NNP
cord-316534-ep7ezoko	158	8	and	and	CC
cord-316534-ep7ezoko	158	9	colleagues	colleague	NNS
cord-316534-ep7ezoko	158	10	in	in	IN
cord-316534-ep7ezoko	158	11	2008	2008	CD
cord-316534-ep7ezoko	158	12	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	158	13	that	that	IN
cord-316534-ep7ezoko	158	14	vaccination	vaccination	NN
cord-316534-ep7ezoko	158	15	by	by	IN
cord-316534-ep7ezoko	158	16	means	mean	NNS
cord-316534-ep7ezoko	158	17	of	of	IN
cord-316534-ep7ezoko	158	18	an	an	DT
cord-316534-ep7ezoko	158	19	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	158	20	clade	clade	NN
cord-316534-ep7ezoko	158	21	C	c	NN
cord-316534-ep7ezoko	158	22	DNA	DNA	NNP
cord-316534-ep7ezoko	158	23	prime	prime	NN
cord-316534-ep7ezoko	158	24	in	in	IN
cord-316534-ep7ezoko	158	25	combination	combination	NN
cord-316534-ep7ezoko	158	26	with	with	IN
cord-316534-ep7ezoko	158	27	a	a	DT
cord-316534-ep7ezoko	158	28	pox	pox	NN
cord-316534-ep7ezoko	158	29	vector	vector	NN
cord-316534-ep7ezoko	158	30	(	(	-LRB-
cord-316534-ep7ezoko	158	31	NYVAC	NYVAC	NNP
cord-316534-ep7ezoko	158	32	)	)	-RRB-
cord-316534-ep7ezoko	158	33	boost	boost	NN
cord-316534-ep7ezoko	158	34	induces	induce	VBZ
cord-316534-ep7ezoko	158	35	a	a	DT
cord-316534-ep7ezoko	158	36	reliable	reliable	JJ
cord-316534-ep7ezoko	158	37	polyfunctional	polyfunctional	JJ
cord-316534-ep7ezoko	158	38	and	and	CC
cord-316534-ep7ezoko	158	39	longlasting	longlasting	JJ
cord-316534-ep7ezoko	158	40	anti	anti	JJ
cord-316534-ep7ezoko	158	41	-	-	JJ
cord-316534-ep7ezoko	158	42	HIV	HIV	NNP
cord-316534-ep7ezoko	158	43	T	t	NN
cord-316534-ep7ezoko	158	44	-	-	HYPH
cord-316534-ep7ezoko	158	45	cell	cell	NN
cord-316534-ep7ezoko	158	46	response	response	NN
cord-316534-ep7ezoko	158	47	in	in	IN
cord-316534-ep7ezoko	158	48	human	human	JJ
cord-316534-ep7ezoko	158	49	participants	participant	NNS
cord-316534-ep7ezoko	158	50	.	.	.
cord-316534-ep7ezoko	159	1	129	129	CD
cord-316534-ep7ezoko	160	1	Along	along	IN
cord-316534-ep7ezoko	160	2	these	these	DT
cord-316534-ep7ezoko	160	3	same	same	JJ
cord-316534-ep7ezoko	160	4	lines	line	NNS
cord-316534-ep7ezoko	160	5	,	,	,
cord-316534-ep7ezoko	160	6	work	work	NN
cord-316534-ep7ezoko	160	7	recently	recently	RB
cord-316534-ep7ezoko	160	8	published	publish	VBN
cord-316534-ep7ezoko	160	9	by	by	IN
cord-316534-ep7ezoko	160	10	Jaoko	Jaoko	NNP
cord-316534-ep7ezoko	160	11	and	and	CC
cord-316534-ep7ezoko	160	12	group	group	NN
cord-316534-ep7ezoko	160	13	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	160	14	safety	safety	NN
cord-316534-ep7ezoko	160	15	and	and	CC
cord-316534-ep7ezoko	160	16	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	160	17	of	of	IN
cord-316534-ep7ezoko	160	18	a	a	DT
cord-316534-ep7ezoko	160	19	multiclade	multiclade	JJ
cord-316534-ep7ezoko	160	20	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	160	21	Ad	Ad	NNP
cord-316534-ep7ezoko	160	22	-	-	HYPH
cord-316534-ep7ezoko	160	23	based	base	VBN
cord-316534-ep7ezoko	160	24	vaccine	vaccine	NN
cord-316534-ep7ezoko	160	25	alone	alone	RB
cord-316534-ep7ezoko	160	26	or	or	CC
cord-316534-ep7ezoko	160	27	in	in	IN
cord-316534-ep7ezoko	160	28	combination	combination	NN
cord-316534-ep7ezoko	160	29	with	with	IN
cord-316534-ep7ezoko	160	30	a	a	DT
cord-316534-ep7ezoko	160	31	multiclade	multiclade	NNP
cord-316534-ep7ezoko	160	32	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	160	33	DNA	DNA	NNP
cord-316534-ep7ezoko	160	34	vaccine	vaccine	NN
cord-316534-ep7ezoko	160	35	in	in	IN
cord-316534-ep7ezoko	160	36	Africa	Africa	NNP
cord-316534-ep7ezoko	160	37	.	.	.
cord-316534-ep7ezoko	161	1	These	these	DT
cord-316534-ep7ezoko	161	2	results	result	NNS
cord-316534-ep7ezoko	161	3	also	also	RB
cord-316534-ep7ezoko	161	4	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	161	5	that	that	IN
cord-316534-ep7ezoko	161	6	DNA	dna	NN
cord-316534-ep7ezoko	161	7	priming	priming	NN
cord-316534-ep7ezoko	161	8	increased	increase	VBD
cord-316534-ep7ezoko	161	9	the	the	DT
cord-316534-ep7ezoko	161	10	frequency	frequency	NN
cord-316534-ep7ezoko	161	11	and	and	CC
cord-316534-ep7ezoko	161	12	magnitude	magnitude	NN
cord-316534-ep7ezoko	161	13	of	of	IN
cord-316534-ep7ezoko	161	14	cellular	cellular	JJ
cord-316534-ep7ezoko	161	15	and	and	CC
cord-316534-ep7ezoko	161	16	humoral	humoral	JJ
cord-316534-ep7ezoko	161	17	responses	response	NNS
cord-316534-ep7ezoko	161	18	;	;	:
cord-316534-ep7ezoko	161	19	however	however	RB
cord-316534-ep7ezoko	161	20	,	,	,
cord-316534-ep7ezoko	161	21	there	there	EX
cord-316534-ep7ezoko	161	22	was	be	VBD
cord-316534-ep7ezoko	161	23	no	no	DT
cord-316534-ep7ezoko	161	24	effect	effect	NN
cord-316534-ep7ezoko	161	25	of	of	IN
cord-316534-ep7ezoko	161	26	recombinant	recombinant	JJ
cord-316534-ep7ezoko	161	27	Ad5	ad5	CD
cord-316534-ep7ezoko	161	28	dosage	dosage	NN
cord-316534-ep7ezoko	161	29	on	on	IN
cord-316534-ep7ezoko	161	30	immunogenicity	immunogenicity	JJ
cord-316534-ep7ezoko	161	31	endpoints	endpoint	NNS
cord-316534-ep7ezoko	161	32	.	.	.
cord-316534-ep7ezoko	162	1	130	130	CD
cord-316534-ep7ezoko	163	1	The	the	DT
cord-316534-ep7ezoko	163	2	previously	previously	RB
cord-316534-ep7ezoko	163	3	mentioned	mention	VBN
cord-316534-ep7ezoko	163	4	DNA	dna	NN
cord-316534-ep7ezoko	163	5	-	-	HYPH
cord-316534-ep7ezoko	163	6	delivery	delivery	NN
cord-316534-ep7ezoko	163	7	strategies	strategy	NNS
cord-316534-ep7ezoko	163	8	have	have	VBP
cord-316534-ep7ezoko	163	9	been	be	VBN
cord-316534-ep7ezoko	163	10	used	use	VBN
cord-316534-ep7ezoko	163	11	in	in	IN
cord-316534-ep7ezoko	163	12	combination	combination	NN
cord-316534-ep7ezoko	163	13	with	with	IN
cord-316534-ep7ezoko	163	14	viral	viral	JJ
cord-316534-ep7ezoko	163	15	vectors	vector	NNS
cord-316534-ep7ezoko	163	16	or	or	CC
cord-316534-ep7ezoko	163	17	alone	alone	RB
cord-316534-ep7ezoko	163	18	by	by	IN
cord-316534-ep7ezoko	163	19	means	mean	NNS
cord-316534-ep7ezoko	163	20	of	of	IN
cord-316534-ep7ezoko	163	21	a	a	DT
cord-316534-ep7ezoko	163	22	variety	variety	NN
cord-316534-ep7ezoko	163	23	of	of	IN
cord-316534-ep7ezoko	163	24	immunization	immunization	NN
cord-316534-ep7ezoko	163	25	routes	route	NNS
cord-316534-ep7ezoko	163	26	(	(	-LRB-
cord-316534-ep7ezoko	163	27	eg	eg	UH
cord-316534-ep7ezoko	163	28	,	,	,
cord-316534-ep7ezoko	163	29	IM	im	UH
cord-316534-ep7ezoko	163	30	,	,	,
cord-316534-ep7ezoko	163	31	intravenous	intravenous	JJ
cord-316534-ep7ezoko	163	32	[	[	-LRB-
cord-316534-ep7ezoko	163	33	IV	IV	NNP
cord-316534-ep7ezoko	163	34	]	]	-RRB-
cord-316534-ep7ezoko	163	35	,	,	,
cord-316534-ep7ezoko	163	36	intradermal	intradermal	JJ
cord-316534-ep7ezoko	163	37	[	[	-LRB-
cord-316534-ep7ezoko	163	38	ID	ID	NNP
cord-316534-ep7ezoko	163	39	]	]	-RRB-
cord-316534-ep7ezoko	163	40	,	,	,
cord-316534-ep7ezoko	163	41	intranasal	intranasal	JJ
cord-316534-ep7ezoko	163	42	[	[	-LRB-
cord-316534-ep7ezoko	163	43	IN	in	IN
cord-316534-ep7ezoko	163	44	]	]	-RRB-
cord-316534-ep7ezoko	163	45	,	,	,
cord-316534-ep7ezoko	163	46	oral	oral	JJ
cord-316534-ep7ezoko	163	47	,	,	,
cord-316534-ep7ezoko	163	48	rectal	rectal	JJ
cord-316534-ep7ezoko	163	49	,	,	,
cord-316534-ep7ezoko	163	50	or	or	CC
cord-316534-ep7ezoko	163	51	vaginal	vaginal	JJ
cord-316534-ep7ezoko	163	52	)	)	-RRB-
cord-316534-ep7ezoko	163	53	.	.	.
cord-316534-ep7ezoko	164	1	In	in	IN
cord-316534-ep7ezoko	164	2	the	the	DT
cord-316534-ep7ezoko	164	3	majority	majority	NN
cord-316534-ep7ezoko	164	4	of	of	IN
cord-316534-ep7ezoko	164	5	reported	report	VBN
cord-316534-ep7ezoko	164	6	studies	study	NNS
cord-316534-ep7ezoko	164	7	,	,	,
cord-316534-ep7ezoko	164	8	DNA	dna	NN
cord-316534-ep7ezoko	164	9	vaccines	vaccine	NNS
cord-316534-ep7ezoko	164	10	have	have	VBP
cord-316534-ep7ezoko	164	11	been	be	VBN
cord-316534-ep7ezoko	164	12	administered	administer	VBN
cord-316534-ep7ezoko	164	13	by	by	IN
cord-316534-ep7ezoko	164	14	the	the	DT
cord-316534-ep7ezoko	164	15	IM	IM	NNP
cord-316534-ep7ezoko	164	16	and/or	and/or	CC
cord-316534-ep7ezoko	164	17	ID	ID	NNP
cord-316534-ep7ezoko	164	18	routes	route	NNS
cord-316534-ep7ezoko	164	19	.	.	.
cord-316534-ep7ezoko	165	1	However	however	RB
cord-316534-ep7ezoko	165	2	,	,	,
cord-316534-ep7ezoko	165	3	as	as	IN
cord-316534-ep7ezoko	165	4	it	-PRON-	PRP
cord-316534-ep7ezoko	165	5	relates	relate	VBZ
cord-316534-ep7ezoko	165	6	to	to	IN
cord-316534-ep7ezoko	165	7	HIV	HIV	NNP
cord-316534-ep7ezoko	165	8	vaccination	vaccination	NN
cord-316534-ep7ezoko	165	9	,	,	,
cord-316534-ep7ezoko	165	10	mucosal	mucosal	JJ
cord-316534-ep7ezoko	165	11	immunity	immunity	NN
cord-316534-ep7ezoko	165	12	could	could	MD
cord-316534-ep7ezoko	165	13	potentially	potentially	RB
cord-316534-ep7ezoko	165	14	be	be	VB
cord-316534-ep7ezoko	165	15	an	an	DT
cord-316534-ep7ezoko	165	16	important	important	JJ
cord-316534-ep7ezoko	165	17	factor	factor	NN
cord-316534-ep7ezoko	165	18	to	to	TO
cord-316534-ep7ezoko	165	19	consider	consider	VB
cord-316534-ep7ezoko	165	20	,	,	,
cord-316534-ep7ezoko	165	21	with	with	IN
cord-316534-ep7ezoko	165	22	mucosal	mucosal	JJ
cord-316534-ep7ezoko	165	23	immunity	immunity	NN
cord-316534-ep7ezoko	165	24	being	be	VBG
cord-316534-ep7ezoko	165	25	achieved	achieve	VBN
cord-316534-ep7ezoko	165	26	optimally	optimally	RB
cord-316534-ep7ezoko	165	27	by	by	IN
cord-316534-ep7ezoko	165	28	IN	in	IN
cord-316534-ep7ezoko	165	29	or	or	CC
cord-316534-ep7ezoko	165	30	oral	oral	JJ
cord-316534-ep7ezoko	165	31	routes	route	NNS
cord-316534-ep7ezoko	165	32	of	of	IN
cord-316534-ep7ezoko	165	33	administration	administration	NN
cord-316534-ep7ezoko	165	34	.	.	.
cord-316534-ep7ezoko	166	1	The	the	DT
cord-316534-ep7ezoko	166	2	topic	topic	NN
cord-316534-ep7ezoko	166	3	of	of	IN
cord-316534-ep7ezoko	166	4	mucosal	mucosal	JJ
cord-316534-ep7ezoko	166	5	immunity	immunity	NN
cord-316534-ep7ezoko	166	6	will	will	MD
cord-316534-ep7ezoko	166	7	be	be	VB
cord-316534-ep7ezoko	166	8	discussed	discuss	VBN
cord-316534-ep7ezoko	166	9	in	in	IN
cord-316534-ep7ezoko	166	10	more	more	JJR
cord-316534-ep7ezoko	166	11	detail	detail	NN
cord-316534-ep7ezoko	166	12	in	in	IN
cord-316534-ep7ezoko	166	13	a	a	DT
cord-316534-ep7ezoko	166	14	later	later	JJ
cord-316534-ep7ezoko	166	15	section	section	NN
cord-316534-ep7ezoko	166	16	within	within	IN
cord-316534-ep7ezoko	166	17	this	this	DT
cord-316534-ep7ezoko	166	18	review	review	NN
cord-316534-ep7ezoko	166	19	.	.	.
cord-316534-ep7ezoko	167	1	After	after	IN
cord-316534-ep7ezoko	167	2	immunization	immunization	NN
cord-316534-ep7ezoko	167	3	,	,	,
cord-316534-ep7ezoko	167	4	it	-PRON-	PRP
cord-316534-ep7ezoko	167	5	is	be	VBZ
cord-316534-ep7ezoko	167	6	assumed	assume	VBN
cord-316534-ep7ezoko	167	7	that	that	IN
cord-316534-ep7ezoko	167	8	the	the	DT
cord-316534-ep7ezoko	167	9	DNA	dna	NN
cord-316534-ep7ezoko	167	10	vaccination	vaccination	NN
cord-316534-ep7ezoko	167	11	immunogen	immunogen	NN
cord-316534-ep7ezoko	167	12	is	be	VBZ
cord-316534-ep7ezoko	167	13	produced	produce	VBN
cord-316534-ep7ezoko	167	14	in	in	IN
cord-316534-ep7ezoko	167	15	the	the	DT
cord-316534-ep7ezoko	167	16	skeletal	skeletal	JJ
cord-316534-ep7ezoko	167	17	muscles	muscle	NNS
cord-316534-ep7ezoko	167	18	,	,	,
cord-316534-ep7ezoko	167	19	dendritic	dendritic	JJ
cord-316534-ep7ezoko	167	20	cells	cell	NNS
cord-316534-ep7ezoko	167	21	,	,	,
cord-316534-ep7ezoko	167	22	and	and	CC
cord-316534-ep7ezoko	167	23	macrophages	macrophage	NNS
cord-316534-ep7ezoko	167	24	at	at	IN
cord-316534-ep7ezoko	167	25	the	the	DT
cord-316534-ep7ezoko	167	26	site	site	NN
cord-316534-ep7ezoko	167	27	of	of	IN
cord-316534-ep7ezoko	167	28	immunization	immunization	NN
cord-316534-ep7ezoko	167	29	.	.	.
cord-316534-ep7ezoko	168	1	However	however	RB
cord-316534-ep7ezoko	168	2	,	,	,
cord-316534-ep7ezoko	168	3	in	in	IN
cord-316534-ep7ezoko	168	4	adults	adult	NNS
cord-316534-ep7ezoko	168	5	,	,	,
cord-316534-ep7ezoko	168	6	the	the	DT
cord-316534-ep7ezoko	168	7	skeletal	skeletal	JJ
cord-316534-ep7ezoko	168	8	muscles	muscle	NNS
cord-316534-ep7ezoko	168	9	are	be	VBP
cord-316534-ep7ezoko	168	10	not	not	RB
cord-316534-ep7ezoko	168	11	involved	involve	VBN
cord-316534-ep7ezoko	168	12	in	in	IN
cord-316534-ep7ezoko	168	13	a	a	DT
cord-316534-ep7ezoko	168	14	high	high	JJ
cord-316534-ep7ezoko	168	15	level	level	NN
cord-316534-ep7ezoko	168	16	of	of	IN
cord-316534-ep7ezoko	168	17	protein	protein	NN
cord-316534-ep7ezoko	168	18	synthesis	synthesis	NN
cord-316534-ep7ezoko	168	19	as	as	IN
cord-316534-ep7ezoko	168	20	compared	compare	VBN
cord-316534-ep7ezoko	168	21	to	to	IN
cord-316534-ep7ezoko	168	22	the	the	DT
cord-316534-ep7ezoko	168	23	liver	liver	NN
cord-316534-ep7ezoko	168	24	.	.	.
cord-316534-ep7ezoko	169	1	Therefore	therefore	RB
cord-316534-ep7ezoko	169	2	,	,	,
cord-316534-ep7ezoko	169	3	the	the	DT
cord-316534-ep7ezoko	169	4	delivery	delivery	NN
cord-316534-ep7ezoko	169	5	of	of	IN
cord-316534-ep7ezoko	169	6	DNA	DNA	NNP
cord-316534-ep7ezoko	169	7	to	to	IN
cord-316534-ep7ezoko	169	8	cells	cell	NNS
cord-316534-ep7ezoko	169	9	,	,	,
cord-316534-ep7ezoko	169	10	which	which	WDT
cord-316534-ep7ezoko	169	11	are	be	VBP
cord-316534-ep7ezoko	169	12	capable	capable	JJ
cord-316534-ep7ezoko	169	13	of	of	IN
cord-316534-ep7ezoko	169	14	high	high	JJ
cord-316534-ep7ezoko	169	15	protein	protein	NN
cord-316534-ep7ezoko	169	16	synthesis	synthesis	NN
cord-316534-ep7ezoko	169	17	,	,	,
cord-316534-ep7ezoko	169	18	such	such	JJ
cord-316534-ep7ezoko	169	19	as	as	IN
cord-316534-ep7ezoko	169	20	hepatocytes	hepatocyte	NNS
cord-316534-ep7ezoko	169	21	,	,	,
cord-316534-ep7ezoko	169	22	epithelia	epithelium	NNS
cord-316534-ep7ezoko	169	23	cells	cell	NNS
cord-316534-ep7ezoko	169	24	of	of	IN
cord-316534-ep7ezoko	169	25	the	the	DT
cord-316534-ep7ezoko	169	26	intestines	intestine	NNS
cord-316534-ep7ezoko	169	27	,	,	,
cord-316534-ep7ezoko	169	28	or	or	CC
cord-316534-ep7ezoko	169	29	salivary	salivary	NN
cord-316534-ep7ezoko	169	30	pancreas	pancrea	NNS
cord-316534-ep7ezoko	169	31	,	,	,
cord-316534-ep7ezoko	169	32	may	may	MD
cord-316534-ep7ezoko	169	33	result	result	VB
cord-316534-ep7ezoko	169	34	in	in	IN
cord-316534-ep7ezoko	169	35	high	high	JJ
cord-316534-ep7ezoko	169	36	levels	level	NNS
cord-316534-ep7ezoko	169	37	of	of	IN
cord-316534-ep7ezoko	169	38	protein	protein	NN
cord-316534-ep7ezoko	169	39	expression	expression	NN
cord-316534-ep7ezoko	169	40	.	.	.
cord-316534-ep7ezoko	170	1	The	the	DT
cord-316534-ep7ezoko	170	2	hepatocytes	hepatocyte	NNS
cord-316534-ep7ezoko	170	3	express	express	VBP
cord-316534-ep7ezoko	170	4	enzymes	enzyme	NNS
cord-316534-ep7ezoko	170	5	involved	involve	VBN
cord-316534-ep7ezoko	170	6	in	in	IN
cord-316534-ep7ezoko	170	7	the	the	DT
cord-316534-ep7ezoko	170	8	formation	formation	NN
cord-316534-ep7ezoko	170	9	of	of	IN
cord-316534-ep7ezoko	170	10	intrachain	intrachain	NNP
cord-316534-ep7ezoko	170	11	and	and	CC
cord-316534-ep7ezoko	170	12	interchain	interchain	JJ
cord-316534-ep7ezoko	170	13	disulfide	disulfide	NN
cord-316534-ep7ezoko	170	14	bonds	bond	NNS
cord-316534-ep7ezoko	170	15	required	require	VBN
cord-316534-ep7ezoko	170	16	for	for	IN
cord-316534-ep7ezoko	170	17	proper	proper	JJ
cord-316534-ep7ezoko	170	18	folding	folding	NN
cord-316534-ep7ezoko	170	19	and	and	CC
cord-316534-ep7ezoko	170	20	assembly	assembly	NN
cord-316534-ep7ezoko	170	21	of	of	IN
cord-316534-ep7ezoko	170	22	proteins	protein	NNS
cord-316534-ep7ezoko	170	23	.	.	.
cord-316534-ep7ezoko	171	1	In	in	IN
cord-316534-ep7ezoko	171	2	addition	addition	NN
cord-316534-ep7ezoko	171	3	,	,	,
cord-316534-ep7ezoko	171	4	the	the	DT
cord-316534-ep7ezoko	171	5	liver	liver	NN
cord-316534-ep7ezoko	171	6	expresses	express	VBZ
cord-316534-ep7ezoko	171	7	glycosyltranferases	glycosyltranferases	NNP
cord-316534-ep7ezoko	171	8	,	,	,
cord-316534-ep7ezoko	171	9	which	which	WDT
cord-316534-ep7ezoko	171	10	are	be	VBP
cord-316534-ep7ezoko	171	11	essential	essential	JJ
cord-316534-ep7ezoko	171	12	for	for	IN
cord-316534-ep7ezoko	171	13	synthesis	synthesis	NN
cord-316534-ep7ezoko	171	14	of	of	IN
cord-316534-ep7ezoko	171	15	both	both	CC
cord-316534-ep7ezoko	171	16	N	N	NNP
cord-316534-ep7ezoko	171	17	-	-	:
cord-316534-ep7ezoko	171	18	and	and	CC
cord-316534-ep7ezoko	171	19	O	o	NN
cord-316534-ep7ezoko	171	20	-	-	HYPH
cord-316534-ep7ezoko	171	21	linked	link	VBN
cord-316534-ep7ezoko	171	22	glycan	glycan	NN
cord-316534-ep7ezoko	171	23	side	side	NN
cord-316534-ep7ezoko	171	24	chains	chain	NNS
cord-316534-ep7ezoko	171	25	;	;	:
cord-316534-ep7ezoko	171	26	this	this	DT
cord-316534-ep7ezoko	171	27	may	may	MD
cord-316534-ep7ezoko	171	28	not	not	RB
cord-316534-ep7ezoko	171	29	be	be	VB
cord-316534-ep7ezoko	171	30	the	the	DT
cord-316534-ep7ezoko	171	31	case	case	NN
cord-316534-ep7ezoko	171	32	for	for	IN
cord-316534-ep7ezoko	171	33	other	other	JJ
cord-316534-ep7ezoko	171	34	cell	cell	NN
cord-316534-ep7ezoko	171	35	types	type	NNS
cord-316534-ep7ezoko	171	36	,	,	,
cord-316534-ep7ezoko	172	1	131,132	131,132	CD
cord-316534-ep7ezoko	172	2	the	the	DT
cord-316534-ep7ezoko	172	3	significance	significance	NN
cord-316534-ep7ezoko	172	4	of	of	IN
cord-316534-ep7ezoko	172	5	this	this	DT
cord-316534-ep7ezoko	172	6	point	point	NN
cord-316534-ep7ezoko	172	7	being	be	VBG
cord-316534-ep7ezoko	172	8	the	the	DT
cord-316534-ep7ezoko	172	9	fact	fact	NN
cord-316534-ep7ezoko	172	10	that	that	IN
cord-316534-ep7ezoko	172	11	broadly	broadly	RB
cord-316534-ep7ezoko	172	12	crossclade	crossclade	NNP
cord-316534-ep7ezoko	172	13	Nabs	Nabs	NNP
cord-316534-ep7ezoko	172	14	such	such	JJ
cord-316534-ep7ezoko	172	15	as	as	IN
cord-316534-ep7ezoko	172	16	2G12	2g12	CD
cord-316534-ep7ezoko	172	17	recognize	recognize	VBP
cord-316534-ep7ezoko	172	18	glycan	glycan	NN
cord-316534-ep7ezoko	172	19	moieties	moiety	NNS
cord-316534-ep7ezoko	172	20	on	on	IN
cord-316534-ep7ezoko	172	21	the	the	DT
cord-316534-ep7ezoko	172	22	heavily	heavily	RB
cord-316534-ep7ezoko	172	23	glycosylated	glycosylate	VBN
cord-316534-ep7ezoko	172	24	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	172	25	envelope	envelope	NN
cord-316534-ep7ezoko	172	26	antigens	antigen	NNS
cord-316534-ep7ezoko	172	27	.	.	.
cord-316534-ep7ezoko	173	1	44	44	CD
cord-316534-ep7ezoko	173	2	,	,	,
cord-316534-ep7ezoko	173	3	133	133	CD
cord-316534-ep7ezoko	173	4	,	,	,
cord-316534-ep7ezoko	173	5	134	134	CD
cord-316534-ep7ezoko	173	6	Another	another	DT
cord-316534-ep7ezoko	173	7	advantage	advantage	NN
cord-316534-ep7ezoko	173	8	of	of	IN
cord-316534-ep7ezoko	173	9	protein	protein	NN
cord-316534-ep7ezoko	173	10	expression	expression	NN
cord-316534-ep7ezoko	173	11	within	within	IN
cord-316534-ep7ezoko	173	12	the	the	DT
cord-316534-ep7ezoko	173	13	liver	liver	NN
cord-316534-ep7ezoko	173	14	is	be	VBZ
cord-316534-ep7ezoko	173	15	that	that	IN
cord-316534-ep7ezoko	173	16	significantly	significantly	RB
cord-316534-ep7ezoko	173	17	lower	low	JJR
cord-316534-ep7ezoko	173	18	amounts	amount	NNS
cord-316534-ep7ezoko	173	19	of	of	IN
cord-316534-ep7ezoko	173	20	DNA	dna	NN
cord-316534-ep7ezoko	173	21	are	be	VBP
cord-316534-ep7ezoko	173	22	needed	need	VBN
cord-316534-ep7ezoko	173	23	for	for	IN
cord-316534-ep7ezoko	173	24	protein	protein	NN
cord-316534-ep7ezoko	173	25	expression	expression	NN
cord-316534-ep7ezoko	173	26	of	of	IN
cord-316534-ep7ezoko	173	27	a	a	DT
cord-316534-ep7ezoko	173	28	particular	particular	JJ
cord-316534-ep7ezoko	173	29	antigen	antigen	NN
cord-316534-ep7ezoko	173	30	in	in	IN
cord-316534-ep7ezoko	173	31	the	the	DT
cord-316534-ep7ezoko	173	32	hepatocytes	hepatocyte	NNS
cord-316534-ep7ezoko	173	33	vs	vs	IN
cord-316534-ep7ezoko	173	34	another	another	DT
cord-316534-ep7ezoko	173	35	cell	cell	NN
cord-316534-ep7ezoko	173	36	type	type	NN
cord-316534-ep7ezoko	173	37	.	.	.
cord-316534-ep7ezoko	174	1	For	for	IN
cord-316534-ep7ezoko	174	2	the	the	DT
cord-316534-ep7ezoko	174	3	immunization	immunization	NN
cord-316534-ep7ezoko	174	4	of	of	IN
cord-316534-ep7ezoko	174	5	humans	human	NNS
cord-316534-ep7ezoko	174	6	,	,	,
cord-316534-ep7ezoko	174	7	milligram	milligram	NN
cord-316534-ep7ezoko	174	8	quantities	quantity	NNS
cord-316534-ep7ezoko	174	9	of	of	IN
cord-316534-ep7ezoko	174	10	DNA	DNA	NNP
cord-316534-ep7ezoko	174	11	are	be	VBP
cord-316534-ep7ezoko	174	12	necessary	necessary	JJ
cord-316534-ep7ezoko	174	13	to	to	TO
cord-316534-ep7ezoko	174	14	achieve	achieve	VB
cord-316534-ep7ezoko	174	15	adequate	adequate	JJ
cord-316534-ep7ezoko	174	16	levels	level	NNS
cord-316534-ep7ezoko	174	17	of	of	IN
cord-316534-ep7ezoko	174	18	immune	immune	JJ
cord-316534-ep7ezoko	174	19	response	response	NN
cord-316534-ep7ezoko	174	20	.	.	.
cord-316534-ep7ezoko	175	1	119	119	CD
cord-316534-ep7ezoko	176	1	Any	any	DT
cord-316534-ep7ezoko	176	2	method	method	NN
cord-316534-ep7ezoko	176	3	whereby	whereby	WRB
cord-316534-ep7ezoko	176	4	there	there	EX
cord-316534-ep7ezoko	176	5	would	would	MD
cord-316534-ep7ezoko	176	6	be	be	VB
cord-316534-ep7ezoko	176	7	a	a	DT
cord-316534-ep7ezoko	176	8	reduction	reduction	NN
cord-316534-ep7ezoko	176	9	in	in	IN
cord-316534-ep7ezoko	176	10	DNA	dna	NN
cord-316534-ep7ezoko	176	11	quantity	quantity	NN
cord-316534-ep7ezoko	176	12	needed	need	VBN
cord-316534-ep7ezoko	176	13	to	to	TO
cord-316534-ep7ezoko	176	14	vaccinate	vaccinate	VB
cord-316534-ep7ezoko	176	15	humans	human	NNS
cord-316534-ep7ezoko	176	16	would	would	MD
cord-316534-ep7ezoko	176	17	provide	provide	VB
cord-316534-ep7ezoko	176	18	significant	significant	JJ
cord-316534-ep7ezoko	176	19	economic	economic	JJ
cord-316534-ep7ezoko	176	20	advantages	advantage	NNS
cord-316534-ep7ezoko	176	21	.	.	.
cord-316534-ep7ezoko	177	1	Based	base	VBN
cord-316534-ep7ezoko	177	2	on	on	IN
cord-316534-ep7ezoko	177	3	the	the	DT
cord-316534-ep7ezoko	177	4	previously	previously	RB
cord-316534-ep7ezoko	177	5	mentioned	mention	VBN
cord-316534-ep7ezoko	177	6	reasons	reason	NNS
cord-316534-ep7ezoko	177	7	,	,	,
cord-316534-ep7ezoko	177	8	it	-PRON-	PRP
cord-316534-ep7ezoko	177	9	is	be	VBZ
cord-316534-ep7ezoko	177	10	not	not	RB
cord-316534-ep7ezoko	177	11	a	a	DT
cord-316534-ep7ezoko	177	12	surprise	surprise	NN
cord-316534-ep7ezoko	177	13	that	that	IN
cord-316534-ep7ezoko	177	14	the	the	DT
cord-316534-ep7ezoko	177	15	liver	liver	NN
cord-316534-ep7ezoko	177	16	has	have	VBZ
cord-316534-ep7ezoko	177	17	been	be	VBN
cord-316534-ep7ezoko	177	18	exploited	exploit	VBN
cord-316534-ep7ezoko	177	19	extensively	extensively	RB
cord-316534-ep7ezoko	177	20	as	as	IN
cord-316534-ep7ezoko	177	21	a	a	DT
cord-316534-ep7ezoko	177	22	site	site	NN
cord-316534-ep7ezoko	177	23	for	for	IN
cord-316534-ep7ezoko	177	24	gene	gene	NN
cord-316534-ep7ezoko	177	25	delivery	delivery	NN
cord-316534-ep7ezoko	177	26	due	due	IN
cord-316534-ep7ezoko	177	27	to	to	IN
cord-316534-ep7ezoko	177	28	its	-PRON-	PRP$
cord-316534-ep7ezoko	177	29	ability	ability	NN
cord-316534-ep7ezoko	177	30	to	to	TO
cord-316534-ep7ezoko	177	31	produce	produce	VB
cord-316534-ep7ezoko	177	32	proteins	protein	NNS
cord-316534-ep7ezoko	177	33	and	and	CC
cord-316534-ep7ezoko	177	34	glycoproteins	glycoprotein	NNS
cord-316534-ep7ezoko	177	35	.	.	.
cord-316534-ep7ezoko	178	1	[	[	-LRB-
cord-316534-ep7ezoko	178	2	135	135	CD
cord-316534-ep7ezoko	178	3	]	]	-RRB-
cord-316534-ep7ezoko	178	4	[	[	-LRB-
cord-316534-ep7ezoko	178	5	136	136	CD
cord-316534-ep7ezoko	178	6	]	]	-RRB-
cord-316534-ep7ezoko	179	1	[	[	-LRB-
cord-316534-ep7ezoko	179	2	137	137	CD
cord-316534-ep7ezoko	179	3	]	]	-RRB-
cord-316534-ep7ezoko	179	4	[	[	-LRB-
cord-316534-ep7ezoko	179	5	138	138	CD
cord-316534-ep7ezoko	179	6	]	]	-RRB-
cord-316534-ep7ezoko	180	1	Hydrodynamic	Hydrodynamic	NNP
cord-316534-ep7ezoko	180	2	delivery	delivery	NN
cord-316534-ep7ezoko	180	3	is	be	VBZ
cord-316534-ep7ezoko	180	4	the	the	DT
cord-316534-ep7ezoko	180	5	application	application	NN
cord-316534-ep7ezoko	180	6	of	of	IN
cord-316534-ep7ezoko	180	7	controlled	control	VBN
cord-316534-ep7ezoko	180	8	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	180	9	pressure	pressure	NN
cord-316534-ep7ezoko	180	10	in	in	IN
cord-316534-ep7ezoko	180	11	capillaries	capillary	NNS
cord-316534-ep7ezoko	180	12	to	to	TO
cord-316534-ep7ezoko	180	13	enhance	enhance	VB
cord-316534-ep7ezoko	180	14	endothelial	endothelial	JJ
cord-316534-ep7ezoko	180	15	and	and	CC
cord-316534-ep7ezoko	180	16	parenchymal	parenchymal	JJ
cord-316534-ep7ezoko	180	17	cell	cell	NN
cord-316534-ep7ezoko	180	18	permeability	permeability	NN
cord-316534-ep7ezoko	180	19	;	;	:
cord-316534-ep7ezoko	180	20	this	this	DT
cord-316534-ep7ezoko	180	21	methodology	methodology	NN
cord-316534-ep7ezoko	180	22	had	have	VBD
cord-316534-ep7ezoko	180	23	its	-PRON-	PRP$
cord-316534-ep7ezoko	180	24	inception	inception	NN
cord-316534-ep7ezoko	180	25	in	in	IN
cord-316534-ep7ezoko	180	26	the	the	DT
cord-316534-ep7ezoko	180	27	late	late	JJ
cord-316534-ep7ezoko	180	28	1990s	1990	NNS
cord-316534-ep7ezoko	180	29	with	with	IN
cord-316534-ep7ezoko	180	30	investigations	investigation	NNS
cord-316534-ep7ezoko	180	31	into	into	IN
cord-316534-ep7ezoko	180	32	intravascular	intravascular	JJ
cord-316534-ep7ezoko	180	33	injection	injection	NN
cord-316534-ep7ezoko	180	34	of	of	IN
cord-316534-ep7ezoko	180	35	plasmid	plasmid	NN
cord-316534-ep7ezoko	180	36	DNA	dna	NN
cord-316534-ep7ezoko	180	37	solution	solution	NN
cord-316534-ep7ezoko	180	38	for	for	IN
cord-316534-ep7ezoko	180	39	gene	gene	NN
cord-316534-ep7ezoko	180	40	delivery	delivery	NN
cord-316534-ep7ezoko	180	41	in	in	IN
cord-316534-ep7ezoko	180	42	whole	whole	JJ
cord-316534-ep7ezoko	180	43	animals	animal	NNS
cord-316534-ep7ezoko	180	44	.	.	.
cord-316534-ep7ezoko	181	1	[	[	-LRB-
cord-316534-ep7ezoko	181	2	139	139	CD
cord-316534-ep7ezoko	181	3	]	]	-RRB-
cord-316534-ep7ezoko	181	4	[	[	-LRB-
cord-316534-ep7ezoko	181	5	140	140	CD
cord-316534-ep7ezoko	181	6	]	]	-RRB-
cord-316534-ep7ezoko	181	7	[	[	-LRB-
cord-316534-ep7ezoko	181	8	141	141	CD
cord-316534-ep7ezoko	181	9	]	]	-RRB-
cord-316534-ep7ezoko	181	10	[	[	-LRB-
cord-316534-ep7ezoko	181	11	142	142	CD
cord-316534-ep7ezoko	181	12	]	]	-RRB-
cord-316534-ep7ezoko	182	1	Hydrodynamic	Hydrodynamic	NNP
cord-316534-ep7ezoko	182	2	plasmid	plasmid	NN
cord-316534-ep7ezoko	182	3	DNA	dna	NN
cord-316534-ep7ezoko	182	4	delivery	delivery	NN
cord-316534-ep7ezoko	182	5	is	be	VBZ
cord-316534-ep7ezoko	182	6	well	well	RB
cord-316534-ep7ezoko	182	7	tolerated	tolerate	VBN
cord-316534-ep7ezoko	182	8	in	in	IN
cord-316534-ep7ezoko	182	9	mice	mouse	NNS
cord-316534-ep7ezoko	182	10	.	.	.
cord-316534-ep7ezoko	183	1	In	in	IN
cord-316534-ep7ezoko	183	2	2008	2008	CD
cord-316534-ep7ezoko	183	3	,	,	,
cord-316534-ep7ezoko	183	4	Raska	Raska	NNP
cord-316534-ep7ezoko	183	5	and	and	CC
cord-316534-ep7ezoko	183	6	colleagues	colleague	NNS
cord-316534-ep7ezoko	183	7	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	183	8	in	in	IN
cord-316534-ep7ezoko	183	9	mice	mouse	NNS
cord-316534-ep7ezoko	183	10	that	that	IN
cord-316534-ep7ezoko	183	11	IV	IV	NNP
cord-316534-ep7ezoko	183	12	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	183	13	vaccination	vaccination	NN
cord-316534-ep7ezoko	183	14	with	with	IN
cord-316534-ep7ezoko	183	15	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	183	16	envelope	envelope	NN
cord-316534-ep7ezoko	183	17	DNA	dna	NN
cord-316534-ep7ezoko	183	18	injections	injection	NNS
cord-316534-ep7ezoko	183	19	resulted	result	VBD
cord-316534-ep7ezoko	183	20	in	in	IN
cord-316534-ep7ezoko	183	21	high	high	JJ
cord-316534-ep7ezoko	183	22	levels	level	NNS
cord-316534-ep7ezoko	183	23	of	of	IN
cord-316534-ep7ezoko	183	24	expression	expression	NN
cord-316534-ep7ezoko	183	25	of	of	IN
cord-316534-ep7ezoko	183	26	HIV	HIV	NNP
cord-316534-ep7ezoko	183	27	antigen	antigen	NN
cord-316534-ep7ezoko	183	28	in	in	IN
cord-316534-ep7ezoko	183	29	the	the	DT
cord-316534-ep7ezoko	183	30	liver	liver	NN
cord-316534-ep7ezoko	183	31	.	.	.
cord-316534-ep7ezoko	184	1	In	in	IN
cord-316534-ep7ezoko	184	2	mice	mouse	NNS
cord-316534-ep7ezoko	184	3	,	,	,
cord-316534-ep7ezoko	184	4	immunological	immunological	JJ
cord-316534-ep7ezoko	184	5	data	datum	NNS
cord-316534-ep7ezoko	184	6	illustrated	illustrate	VBD
cord-316534-ep7ezoko	184	7	that	that	IN
cord-316534-ep7ezoko	184	8	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	184	9	administration	administration	NN
cord-316534-ep7ezoko	184	10	of	of	IN
cord-316534-ep7ezoko	184	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	184	12	plasmid	plasmid	NN
cord-316534-ep7ezoko	184	13	DNA	DNA	NNP
cord-316534-ep7ezoko	184	14	was	be	VBD
cord-316534-ep7ezoko	184	15	superior	superior	JJ
cord-316534-ep7ezoko	184	16	to	to	IN
cord-316534-ep7ezoko	184	17	vaccination	vaccination	NN
cord-316534-ep7ezoko	184	18	with	with	IN
cord-316534-ep7ezoko	184	19	DNA	DNA	NNP
cord-316534-ep7ezoko	184	20	by	by	IN
cord-316534-ep7ezoko	184	21	IN	IN	NNP
cord-316534-ep7ezoko	184	22	,	,	,
cord-316534-ep7ezoko	184	23	ID	ID	NNP
cord-316534-ep7ezoko	184	24	,	,	,
cord-316534-ep7ezoko	184	25	IM	IM	NNP
cord-316534-ep7ezoko	184	26	,	,	,
cord-316534-ep7ezoko	184	27	and	and	CC
cord-316534-ep7ezoko	184	28	intrasplenic	intrasplenic	JJ
cord-316534-ep7ezoko	184	29	routes	route	NNS
cord-316534-ep7ezoko	184	30	.	.	.
cord-316534-ep7ezoko	185	1	Further	further	JJ
cord-316534-ep7ezoko	185	2	results	result	NNS
cord-316534-ep7ezoko	185	3	illustrated	illustrate	VBD
cord-316534-ep7ezoko	185	4	that	that	IN
cord-316534-ep7ezoko	185	5	after	after	IN
cord-316534-ep7ezoko	185	6	boosting	boost	VBG
cord-316534-ep7ezoko	185	7	,	,	,
cord-316534-ep7ezoko	185	8	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	185	9	vaccination	vaccination	NN
cord-316534-ep7ezoko	185	10	yielded	yield	VBD
cord-316534-ep7ezoko	185	11	levels	level	NNS
cord-316534-ep7ezoko	185	12	of	of	IN
cord-316534-ep7ezoko	185	13	HIV-1-specific	hiv-1-specific	JJ
cord-316534-ep7ezoko	185	14	antibodies	antibody	NNS
cord-316534-ep7ezoko	185	15	that	that	WDT
cord-316534-ep7ezoko	185	16	were	be	VBD
cord-316534-ep7ezoko	185	17	40-fold	40-fold	CD
cord-316534-ep7ezoko	185	18	higher	high	JJR
cord-316534-ep7ezoko	185	19	than	than	IN
cord-316534-ep7ezoko	185	20	those	those	DT
cord-316534-ep7ezoko	185	21	elicited	elicit	VBN
cord-316534-ep7ezoko	185	22	by	by	IN
cord-316534-ep7ezoko	185	23	other	other	JJ
cord-316534-ep7ezoko	185	24	routes	route	NNS
cord-316534-ep7ezoko	185	25	tested	test	VBN
cord-316534-ep7ezoko	185	26	.	.	.
cord-316534-ep7ezoko	186	1	132	132	CD
cord-316534-ep7ezoko	187	1	However	however	RB
cord-316534-ep7ezoko	187	2	,	,	,
cord-316534-ep7ezoko	187	3	this	this	DT
cord-316534-ep7ezoko	187	4	delivery	delivery	NN
cord-316534-ep7ezoko	187	5	scheme	scheme	NN
cord-316534-ep7ezoko	187	6	is	be	VBZ
cord-316534-ep7ezoko	187	7	not	not	RB
cord-316534-ep7ezoko	187	8	feasible	feasible	JJ
cord-316534-ep7ezoko	187	9	in	in	IN
cord-316534-ep7ezoko	187	10	large	large	JJ
cord-316534-ep7ezoko	187	11	animals	animal	NNS
cord-316534-ep7ezoko	187	12	and	and	CC
cord-316534-ep7ezoko	187	13	humans	human	NNS
cord-316534-ep7ezoko	187	14	.	.	.
cord-316534-ep7ezoko	188	1	As	as	IN
cord-316534-ep7ezoko	188	2	an	an	DT
cord-316534-ep7ezoko	188	3	alternative	alternative	NN
cord-316534-ep7ezoko	188	4	,	,	,
cord-316534-ep7ezoko	188	5	receptor	receptor	NN
cord-316534-ep7ezoko	188	6	-	-	HYPH
cord-316534-ep7ezoko	188	7	mediated	mediate	VBN
cord-316534-ep7ezoko	188	8	DNA	dna	NN
cord-316534-ep7ezoko	188	9	binding	binding	NN
cord-316534-ep7ezoko	188	10	to	to	IN
cord-316534-ep7ezoko	188	11	hepatocytes	hepatocyte	NNS
cord-316534-ep7ezoko	188	12	could	could	MD
cord-316534-ep7ezoko	188	13	be	be	VB
cord-316534-ep7ezoko	188	14	a	a	DT
cord-316534-ep7ezoko	188	15	viable	viable	JJ
cord-316534-ep7ezoko	188	16	approach	approach	NN
cord-316534-ep7ezoko	188	17	.	.	.
cord-316534-ep7ezoko	189	1	Molecules	molecule	NNS
cord-316534-ep7ezoko	189	2	with	with	IN
cord-316534-ep7ezoko	189	3	terminal	terminal	JJ
cord-316534-ep7ezoko	189	4	galactose	galactose	NN
cord-316534-ep7ezoko	189	5	residues	residue	NNS
cord-316534-ep7ezoko	189	6	covalently	covalently	RB
cord-316534-ep7ezoko	189	7	linked	link	VBN
cord-316534-ep7ezoko	189	8	to	to	IN
cord-316534-ep7ezoko	189	9	DNA	DNA	NNP
cord-316534-ep7ezoko	189	10	are	be	VBP
cord-316534-ep7ezoko	189	11	recognized	recognize	VBN
cord-316534-ep7ezoko	189	12	by	by	IN
cord-316534-ep7ezoko	189	13	the	the	DT
cord-316534-ep7ezoko	189	14	hepatocyte	hepatocyte	NN
cord-316534-ep7ezoko	189	15	-	-	HYPH
cord-316534-ep7ezoko	189	16	expressed	express	VBN
cord-316534-ep7ezoko	189	17	galactosespecific	galactosespecific	NNP
cord-316534-ep7ezoko	189	18	asialoglycoprotein	asialoglycoprotein	NNP
cord-316534-ep7ezoko	189	19	143	143	CD
cord-316534-ep7ezoko	189	20	receptor	receptor	NN
cord-316534-ep7ezoko	189	21	for	for	IN
cord-316534-ep7ezoko	189	22	internalization	internalization	NN
cord-316534-ep7ezoko	189	23	.	.	.
cord-316534-ep7ezoko	190	1	144	144	CD
cord-316534-ep7ezoko	191	1	This	this	DT
cord-316534-ep7ezoko	191	2	alternative	alternative	NN
cord-316534-ep7ezoko	191	3	would	would	MD
cord-316534-ep7ezoko	191	4	avoid	avoid	VB
cord-316534-ep7ezoko	191	5	delivery	delivery	NN
cord-316534-ep7ezoko	191	6	through	through	IN
cord-316534-ep7ezoko	191	7	the	the	DT
cord-316534-ep7ezoko	191	8	hepatic	hepatic	JJ
cord-316534-ep7ezoko	191	9	system	system	NN
cord-316534-ep7ezoko	191	10	and	and	CC
cord-316534-ep7ezoko	191	11	the	the	DT
cord-316534-ep7ezoko	191	12	need	need	NN
cord-316534-ep7ezoko	191	13	for	for	IN
cord-316534-ep7ezoko	191	14	expansion	expansion	NN
cord-316534-ep7ezoko	191	15	of	of	IN
cord-316534-ep7ezoko	191	16	the	the	DT
cord-316534-ep7ezoko	191	17	blood	blood	NN
cord-316534-ep7ezoko	191	18	volume	volume	NN
cord-316534-ep7ezoko	191	19	.	.	.
cord-316534-ep7ezoko	192	1	In	in	IN
cord-316534-ep7ezoko	192	2	addition	addition	NN
cord-316534-ep7ezoko	192	3	,	,	,
cord-316534-ep7ezoko	192	4	galactose	galactose	NN
cord-316534-ep7ezoko	192	5	-	-	HYPH
cord-316534-ep7ezoko	192	6	linked	link	VBN
cord-316534-ep7ezoko	192	7	DNA	dna	NN
cord-316534-ep7ezoko	192	8	packaged	package	VBN
cord-316534-ep7ezoko	192	9	in	in	IN
cord-316534-ep7ezoko	192	10	delivery	delivery	NN
cord-316534-ep7ezoko	192	11	vehicles	vehicle	NNS
cord-316534-ep7ezoko	192	12	such	such	JJ
cord-316534-ep7ezoko	192	13	as	as	IN
cord-316534-ep7ezoko	192	14	liposomes	liposome	NNS
cord-316534-ep7ezoko	192	15	,	,	,
cord-316534-ep7ezoko	192	16	choleates	choleate	NNS
cord-316534-ep7ezoko	192	17	,	,	,
cord-316534-ep7ezoko	192	18	or	or	CC
cord-316534-ep7ezoko	192	19	microspheres	microsphere	NNS
cord-316534-ep7ezoko	192	20	can	can	MD
cord-316534-ep7ezoko	192	21	be	be	VB
cord-316534-ep7ezoko	192	22	given	give	VBN
cord-316534-ep7ezoko	192	23	by	by	IN
cord-316534-ep7ezoko	192	24	oral	oral	JJ
cord-316534-ep7ezoko	192	25	administration	administration	NN
cord-316534-ep7ezoko	192	26	,	,	,
cord-316534-ep7ezoko	192	27	which	which	WDT
cord-316534-ep7ezoko	192	28	would	would	MD
cord-316534-ep7ezoko	192	29	be	be	VB
cord-316534-ep7ezoko	192	30	absorbed	absorb	VBN
cord-316534-ep7ezoko	192	31	by	by	IN
cord-316534-ep7ezoko	192	32	the	the	DT
cord-316534-ep7ezoko	192	33	intestine	intestine	NN
cord-316534-ep7ezoko	192	34	and	and	CC
cord-316534-ep7ezoko	192	35	ultimately	ultimately	RB
cord-316534-ep7ezoko	192	36	delivered	deliver	VBD
cord-316534-ep7ezoko	192	37	to	to	IN
cord-316534-ep7ezoko	192	38	the	the	DT
cord-316534-ep7ezoko	192	39	hepatic	hepatic	JJ
cord-316534-ep7ezoko	192	40	vein	vein	NN
cord-316534-ep7ezoko	192	41	.	.	.
cord-316534-ep7ezoko	193	1	As	as	IN
cord-316534-ep7ezoko	193	2	an	an	DT
cord-316534-ep7ezoko	193	3	additional	additional	JJ
cord-316534-ep7ezoko	193	4	alternative	alternative	NN
cord-316534-ep7ezoko	193	5	to	to	IN
cord-316534-ep7ezoko	193	6	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	193	7	delivery	delivery	NN
cord-316534-ep7ezoko	193	8	in	in	IN
cord-316534-ep7ezoko	193	9	humans	human	NNS
cord-316534-ep7ezoko	193	10	,	,	,
cord-316534-ep7ezoko	193	11	it	-PRON-	PRP
cord-316534-ep7ezoko	193	12	might	may	MD
cord-316534-ep7ezoko	193	13	be	be	VB
cord-316534-ep7ezoko	193	14	possible	possible	JJ
cord-316534-ep7ezoko	193	15	to	to	TO
cord-316534-ep7ezoko	193	16	express	express	VB
cord-316534-ep7ezoko	193	17	HIV	HIV	NNP
cord-316534-ep7ezoko	193	18	antigens	antigen	NNS
cord-316534-ep7ezoko	193	19	in	in	IN
cord-316534-ep7ezoko	193	20	the	the	DT
cord-316534-ep7ezoko	193	21	liver	liver	NN
cord-316534-ep7ezoko	193	22	by	by	IN
cord-316534-ep7ezoko	193	23	means	mean	NNS
cord-316534-ep7ezoko	193	24	of	of	IN
cord-316534-ep7ezoko	193	25	plasmid	plasmid	NN
cord-316534-ep7ezoko	193	26	DNA	dna	NN
cord-316534-ep7ezoko	193	27	delivery	delivery	NN
cord-316534-ep7ezoko	193	28	via	via	IN
cord-316534-ep7ezoko	193	29	viral	viral	JJ
cord-316534-ep7ezoko	193	30	vectors	vector	NNS
cord-316534-ep7ezoko	193	31	such	such	JJ
cord-316534-ep7ezoko	193	32	as	as	IN
cord-316534-ep7ezoko	193	33	the	the	DT
cord-316534-ep7ezoko	193	34	Ad	ad	NN
cord-316534-ep7ezoko	193	35	.	.	.
cord-316534-ep7ezoko	194	1	Ads	ad	NNS
cord-316534-ep7ezoko	194	2	have	have	VBP
cord-316534-ep7ezoko	194	3	been	be	VBN
cord-316534-ep7ezoko	194	4	shown	show	VBN
cord-316534-ep7ezoko	194	5	to	to	TO
cord-316534-ep7ezoko	194	6	transduce	transduce	VB
cord-316534-ep7ezoko	194	7	the	the	DT
cord-316534-ep7ezoko	194	8	liver	liver	NN
cord-316534-ep7ezoko	194	9	efficiently	efficiently	RB
cord-316534-ep7ezoko	194	10	in	in	IN
cord-316534-ep7ezoko	194	11	vivo	vivo	NN
cord-316534-ep7ezoko	194	12	by	by	IN
cord-316534-ep7ezoko	194	13	means	mean	NNS
cord-316534-ep7ezoko	194	14	of	of	IN
cord-316534-ep7ezoko	194	15	the	the	DT
cord-316534-ep7ezoko	194	16	hexon	hexon	NNP
cord-316534-ep7ezoko	194	17	proteins	protein	NNS
cord-316534-ep7ezoko	194	18	.	.	.
cord-316534-ep7ezoko	195	1	145	145	CD
cord-316534-ep7ezoko	196	1	,	,	,
cord-316534-ep7ezoko	196	2	146	146	CD
cord-316534-ep7ezoko	197	1	In	in	IN
cord-316534-ep7ezoko	197	2	this	this	DT
cord-316534-ep7ezoko	197	3	regard	regard	NN
cord-316534-ep7ezoko	197	4	,	,	,
cord-316534-ep7ezoko	197	5	production	production	NN
cord-316534-ep7ezoko	197	6	of	of	IN
cord-316534-ep7ezoko	197	7	translation	translation	NN
cord-316534-ep7ezoko	197	8	of	of	IN
cord-316534-ep7ezoko	197	9	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	197	10	proteins	protein	NNS
cord-316534-ep7ezoko	197	11	primarily	primarily	RB
cord-316534-ep7ezoko	197	12	in	in	IN
cord-316534-ep7ezoko	197	13	the	the	DT
cord-316534-ep7ezoko	197	14	liver	liver	NN
cord-316534-ep7ezoko	197	15	might	may	MD
cord-316534-ep7ezoko	197	16	allow	allow	VB
cord-316534-ep7ezoko	197	17	for	for	IN
cord-316534-ep7ezoko	197	18	the	the	DT
cord-316534-ep7ezoko	197	19	production	production	NN
cord-316534-ep7ezoko	197	20	of	of	IN
cord-316534-ep7ezoko	197	21	heavily	heavily	RB
cord-316534-ep7ezoko	197	22	glycosylated	glycosylate	VBN
cord-316534-ep7ezoko	197	23	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	197	24	envelope	envelope	NN
cord-316534-ep7ezoko	197	25	antigens	antigen	NNS
cord-316534-ep7ezoko	197	26	and	and	CC
cord-316534-ep7ezoko	197	27	thus	thus	RB
cord-316534-ep7ezoko	197	28	the	the	DT
cord-316534-ep7ezoko	197	29	production	production	NN
cord-316534-ep7ezoko	197	30	of	of	IN
cord-316534-ep7ezoko	197	31	Nabs	Nabs	NNP
cord-316534-ep7ezoko	197	32	.	.	.
cord-316534-ep7ezoko	197	33	 	 	_SP
cord-316534-ep7ezoko	198	1	Prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	198	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	198	3	for	for	IN
cord-316534-ep7ezoko	198	4	Hiv-1	Hiv-1	NNP
cord-316534-ep7ezoko	198	5	Live	live	JJ
cord-316534-ep7ezoko	198	6	recombinant	recombinant	JJ
cord-316534-ep7ezoko	198	7	vectors	vector	NNS
cord-316534-ep7ezoko	198	8	for	for	IN
cord-316534-ep7ezoko	198	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	198	10	development	development	NN
cord-316534-ep7ezoko	198	11	Viral	viral	JJ
cord-316534-ep7ezoko	198	12	vectors	vector	NNS
cord-316534-ep7ezoko	198	13	are	be	VBP
cord-316534-ep7ezoko	198	14	potent	potent	JJ
cord-316534-ep7ezoko	198	15	inducers	inducer	NNS
cord-316534-ep7ezoko	198	16	of	of	IN
cord-316534-ep7ezoko	198	17	cellular	cellular	JJ
cord-316534-ep7ezoko	198	18	and	and	CC
cord-316534-ep7ezoko	198	19	humoral	humoral	JJ
cord-316534-ep7ezoko	198	20	response	response	NN
cord-316534-ep7ezoko	198	21	.	.	.
cord-316534-ep7ezoko	199	1	Viral	viral	JJ
cord-316534-ep7ezoko	199	2	vectors	vector	NNS
cord-316534-ep7ezoko	199	3	can	can	MD
cord-316534-ep7ezoko	199	4	express	express	VB
cord-316534-ep7ezoko	199	5	proteins	protein	NNS
cord-316534-ep7ezoko	199	6	from	from	IN
cord-316534-ep7ezoko	199	7	bacteria	bacteria	NNS
cord-316534-ep7ezoko	199	8	or	or	CC
cord-316534-ep7ezoko	199	9	viral	viral	JJ
cord-316534-ep7ezoko	199	10	pathogens	pathogen	NNS
cord-316534-ep7ezoko	199	11	to	to	TO
cord-316534-ep7ezoko	199	12	vaccinate	vaccinate	VB
cord-316534-ep7ezoko	199	13	against	against	IN
cord-316534-ep7ezoko	199	14	infectious	infectious	JJ
cord-316534-ep7ezoko	199	15	diseases	disease	NNS
cord-316534-ep7ezoko	199	16	.	.	.
cord-316534-ep7ezoko	200	1	There	there	EX
cord-316534-ep7ezoko	200	2	are	be	VBP
cord-316534-ep7ezoko	200	3	several	several	JJ
cord-316534-ep7ezoko	200	4	viral	viral	JJ
cord-316534-ep7ezoko	200	5	vaccine	vaccine	NN
cord-316534-ep7ezoko	200	6	vectors	vector	NNS
cord-316534-ep7ezoko	200	7	that	that	WDT
cord-316534-ep7ezoko	200	8	have	have	VBP
cord-316534-ep7ezoko	200	9	been	be	VBN
cord-316534-ep7ezoko	200	10	used	use	VBN
cord-316534-ep7ezoko	200	11	successfully	successfully	RB
cord-316534-ep7ezoko	200	12	in	in	IN
cord-316534-ep7ezoko	200	13	models	model	NNS
cord-316534-ep7ezoko	200	14	for	for	IN
cord-316534-ep7ezoko	200	15	vaccination	vaccination	NN
cord-316534-ep7ezoko	200	16	.	.	.
cord-316534-ep7ezoko	201	1	These	these	DT
cord-316534-ep7ezoko	201	2	vectors	vector	NNS
cord-316534-ep7ezoko	201	3	include	include	VBP
cord-316534-ep7ezoko	201	4	alphaviruses	alphavirus	NNS
cord-316534-ep7ezoko	201	5	,	,	,
cord-316534-ep7ezoko	201	6	human	human	JJ
cord-316534-ep7ezoko	201	7	rhinoviruses	rhinovirus	NNS
cord-316534-ep7ezoko	201	8	(	(	-LRB-
cord-316534-ep7ezoko	201	9	HRVs	HRVs	NNP
cord-316534-ep7ezoko	201	10	)	)	-RRB-
cord-316534-ep7ezoko	201	11	,	,	,
cord-316534-ep7ezoko	201	12	Ads	ad	NNS
cord-316534-ep7ezoko	201	13	,	,	,
cord-316534-ep7ezoko	201	14	picornaviruses	picornavirus	NNS
cord-316534-ep7ezoko	201	15	,	,	,
cord-316534-ep7ezoko	201	16	poxviruses	poxvirus	NNS
cord-316534-ep7ezoko	201	17	,	,	,
cord-316534-ep7ezoko	201	18	measles	measles	NN
cord-316534-ep7ezoko	201	19	viruses	virus	NNS
cord-316534-ep7ezoko	201	20	,	,	,
cord-316534-ep7ezoko	201	21	influenza	influenza	NN
cord-316534-ep7ezoko	201	22	,	,	,
cord-316534-ep7ezoko	201	23	and	and	CC
cord-316534-ep7ezoko	201	24	vaccinia	vaccinia	NN
cord-316534-ep7ezoko	201	25	viruses	virus	NNS
cord-316534-ep7ezoko	201	26	.	.	.
cord-316534-ep7ezoko	202	1	30	30	CD
cord-316534-ep7ezoko	202	2	,	,	,
cord-316534-ep7ezoko	202	3	129	129	CD
cord-316534-ep7ezoko	202	4	,	,	,
cord-316534-ep7ezoko	202	5	[	[	-LRB-
cord-316534-ep7ezoko	202	6	147	147	CD
cord-316534-ep7ezoko	202	7	]	]	-RRB-
cord-316534-ep7ezoko	202	8	[	[	-LRB-
cord-316534-ep7ezoko	202	9	148	148	CD
cord-316534-ep7ezoko	202	10	]	]	-RRB-
cord-316534-ep7ezoko	202	11	[	[	-LRB-
cord-316534-ep7ezoko	202	12	149	149	CD
cord-316534-ep7ezoko	202	13	]	]	-RRB-
cord-316534-ep7ezoko	202	14	[	[	-LRB-
cord-316534-ep7ezoko	202	15	150	150	CD
cord-316534-ep7ezoko	202	16	]	]	-RRB-
cord-316534-ep7ezoko	203	1	[	[	-LRB-
cord-316534-ep7ezoko	203	2	151	151	CD
cord-316534-ep7ezoko	203	3	]	]	-RRB-
cord-316534-ep7ezoko	203	4	[	[	-LRB-
cord-316534-ep7ezoko	203	5	152	152	CD
cord-316534-ep7ezoko	203	6	]	]	-RRB-
cord-316534-ep7ezoko	203	7	[	[	-LRB-
cord-316534-ep7ezoko	203	8	153	153	CD
cord-316534-ep7ezoko	203	9	]	]	-RRB-
cord-316534-ep7ezoko	203	10	[	[	-LRB-
cord-316534-ep7ezoko	203	11	154	154	CD
cord-316534-ep7ezoko	203	12	]	]	-RRB-
cord-316534-ep7ezoko	203	13	[	[	-LRB-
cord-316534-ep7ezoko	203	14	155	155	CD
cord-316534-ep7ezoko	203	15	]	]	-RRB-
cord-316534-ep7ezoko	204	1	[	[	-LRB-
cord-316534-ep7ezoko	204	2	156	156	CD
cord-316534-ep7ezoko	204	3	]	]	-RRB-
cord-316534-ep7ezoko	204	4	Each	each	DT
cord-316534-ep7ezoko	204	5	of	of	IN
cord-316534-ep7ezoko	204	6	these	these	DT
cord-316534-ep7ezoko	204	7	vectors	vector	NNS
cord-316534-ep7ezoko	204	8	has	have	VBZ
cord-316534-ep7ezoko	204	9	its	-PRON-	PRP$
cord-316534-ep7ezoko	204	10	respective	respective	JJ
cord-316534-ep7ezoko	204	11	disadvantages	disadvantage	NNS
cord-316534-ep7ezoko	204	12	and	and	CC
cord-316534-ep7ezoko	204	13	advantages	advantage	NNS
cord-316534-ep7ezoko	204	14	with	with	IN
cord-316534-ep7ezoko	204	15	respect	respect	NN
cord-316534-ep7ezoko	204	16	to	to	IN
cord-316534-ep7ezoko	204	17	vaccine	vaccine	NN
cord-316534-ep7ezoko	204	18	development	development	NN
cord-316534-ep7ezoko	204	19	.	.	.
cord-316534-ep7ezoko	205	1	Some	some	DT
cord-316534-ep7ezoko	205	2	advantages	advantage	NNS
cord-316534-ep7ezoko	205	3	of	of	IN
cord-316534-ep7ezoko	205	4	a	a	DT
cord-316534-ep7ezoko	205	5	few	few	JJ
cord-316534-ep7ezoko	205	6	of	of	IN
cord-316534-ep7ezoko	205	7	these	these	DT
cord-316534-ep7ezoko	205	8	vectors	vector	NNS
cord-316534-ep7ezoko	205	9	include	include	VBP
cord-316534-ep7ezoko	205	10	their	-PRON-	PRP$
cord-316534-ep7ezoko	205	11	ability	ability	NN
cord-316534-ep7ezoko	205	12	to	to	TO
cord-316534-ep7ezoko	205	13	naturally	naturally	RB
cord-316534-ep7ezoko	205	14	infect	infect	VB
cord-316534-ep7ezoko	205	15	a	a	DT
cord-316534-ep7ezoko	205	16	wide	wide	JJ
cord-316534-ep7ezoko	205	17	variety	variety	NN
cord-316534-ep7ezoko	205	18	of	of	IN
cord-316534-ep7ezoko	205	19	cell	cell	NN
cord-316534-ep7ezoko	205	20	types	type	NNS
cord-316534-ep7ezoko	205	21	and	and	CC
cord-316534-ep7ezoko	205	22	tissues	tissue	NNS
cord-316534-ep7ezoko	205	23	of	of	IN
cord-316534-ep7ezoko	205	24	interest	interest	NN
cord-316534-ep7ezoko	205	25	.	.	.
cord-316534-ep7ezoko	206	1	[	[	-LRB-
cord-316534-ep7ezoko	206	2	157	157	CD
cord-316534-ep7ezoko	206	3	]	]	-RRB-
cord-316534-ep7ezoko	206	4	[	[	-LRB-
cord-316534-ep7ezoko	206	5	158	158	CD
cord-316534-ep7ezoko	206	6	]	]	-RRB-
cord-316534-ep7ezoko	206	7	[	[	-LRB-
cord-316534-ep7ezoko	206	8	159	159	CD
cord-316534-ep7ezoko	206	9	]	]	-RRB-
cord-316534-ep7ezoko	206	10	[	[	-LRB-
cord-316534-ep7ezoko	206	11	160	160	CD
cord-316534-ep7ezoko	206	12	]	]	-RRB-
cord-316534-ep7ezoko	206	13	[	[	-LRB-
cord-316534-ep7ezoko	206	14	161	161	CD
cord-316534-ep7ezoko	206	15	]	]	-RRB-
cord-316534-ep7ezoko	207	1	[	[	-LRB-
cord-316534-ep7ezoko	207	2	162	162	CD
cord-316534-ep7ezoko	207	3	]	]	-RRB-
cord-316534-ep7ezoko	208	1	Each	each	DT
cord-316534-ep7ezoko	208	2	respective	respective	JJ
cord-316534-ep7ezoko	208	3	vector	vector	NN
cord-316534-ep7ezoko	208	4	has	have	VBZ
cord-316534-ep7ezoko	208	5	its	-PRON-	PRP$
cord-316534-ep7ezoko	208	6	own	own	JJ
cord-316534-ep7ezoko	208	7	set	set	NN
cord-316534-ep7ezoko	208	8	of	of	IN
cord-316534-ep7ezoko	208	9	disadvantages	disadvantage	NNS
cord-316534-ep7ezoko	208	10	.	.	.
cord-316534-ep7ezoko	209	1	For	for	IN
cord-316534-ep7ezoko	209	2	instance	instance	NN
cord-316534-ep7ezoko	209	3	,	,	,
cord-316534-ep7ezoko	209	4	one	one	CD
cord-316534-ep7ezoko	209	5	disadvantage	disadvantage	NN
cord-316534-ep7ezoko	209	6	of	of	IN
cord-316534-ep7ezoko	209	7	using	use	VBG
cord-316534-ep7ezoko	209	8	the	the	DT
cord-316534-ep7ezoko	209	9	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	209	10	or	or	CC
cord-316534-ep7ezoko	209	11	the	the	DT
cord-316534-ep7ezoko	209	12	HRV	HRV	NNP
cord-316534-ep7ezoko	209	13	as	as	IN
cord-316534-ep7ezoko	209	14	a	a	DT
cord-316534-ep7ezoko	209	15	vaccine	vaccine	NN
cord-316534-ep7ezoko	209	16	vector	vector	NN
cord-316534-ep7ezoko	209	17	is	be	VBZ
cord-316534-ep7ezoko	209	18	the	the	DT
cord-316534-ep7ezoko	209	19	insert	insert	JJ
cord-316534-ep7ezoko	209	20	size	size	NN
cord-316534-ep7ezoko	209	21	limit	limit	NN
cord-316534-ep7ezoko	209	22	restriction	restriction	NN
cord-316534-ep7ezoko	209	23	of	of	IN
cord-316534-ep7ezoko	209	24	these	these	DT
cord-316534-ep7ezoko	209	25	vectors	vector	NNS
cord-316534-ep7ezoko	209	26	as	as	IN
cord-316534-ep7ezoko	209	27	compared	compare	VBN
cord-316534-ep7ezoko	209	28	to	to	IN
cord-316534-ep7ezoko	209	29	the	the	DT
cord-316534-ep7ezoko	209	30	large	large	JJ
cord-316534-ep7ezoko	209	31	insert	insert	NN
cord-316534-ep7ezoko	209	32	size	size	NN
cord-316534-ep7ezoko	209	33	(	(	-LRB-
cord-316534-ep7ezoko	209	34	∼8	∼8	NNP
cord-316534-ep7ezoko	209	35	kb	kb	NNP
cord-316534-ep7ezoko	209	36	)	)	-RRB-
cord-316534-ep7ezoko	209	37	accommodation	accommodation	NN
cord-316534-ep7ezoko	209	38	of	of	IN
cord-316534-ep7ezoko	209	39	Ad	ad	NN
cord-316534-ep7ezoko	209	40	vectors	vector	NNS
cord-316534-ep7ezoko	209	41	.	.	.
cord-316534-ep7ezoko	210	1	The	the	DT
cord-316534-ep7ezoko	210	2	most	most	RBS
cord-316534-ep7ezoko	210	3	common	common	JJ
cord-316534-ep7ezoko	210	4	disadvantage	disadvantage	NN
cord-316534-ep7ezoko	210	5	of	of	IN
cord-316534-ep7ezoko	210	6	the	the	DT
cord-316534-ep7ezoko	210	7	majority	majority	NN
cord-316534-ep7ezoko	210	8	of	of	IN
cord-316534-ep7ezoko	210	9	viral	viral	JJ
cord-316534-ep7ezoko	210	10	vaccine	vaccine	NN
cord-316534-ep7ezoko	210	11	vectors	vector	NNS
cord-316534-ep7ezoko	210	12	is	be	VBZ
cord-316534-ep7ezoko	210	13	reduced	reduce	VBN
cord-316534-ep7ezoko	210	14	vaccine	vaccine	NN
cord-316534-ep7ezoko	210	15	efficacy	efficacy	NN
cord-316534-ep7ezoko	210	16	due	due	IN
cord-316534-ep7ezoko	210	17	to	to	IN
cord-316534-ep7ezoko	210	18	vector	vector	NN
cord-316534-ep7ezoko	210	19	preexisting	preexist	VBG
cord-316534-ep7ezoko	210	20	immunity	immunity	NN
cord-316534-ep7ezoko	210	21	(	(	-LRB-
cord-316534-ep7ezoko	210	22	PEI	PEI	NNP
cord-316534-ep7ezoko	210	23	)	)	-RRB-
cord-316534-ep7ezoko	210	24	.	.	.
cord-316534-ep7ezoko	211	1	[	[	-LRB-
cord-316534-ep7ezoko	211	2	163	163	CD
cord-316534-ep7ezoko	211	3	]	]	-RRB-
cord-316534-ep7ezoko	211	4	[	[	-LRB-
cord-316534-ep7ezoko	211	5	164	164	CD
cord-316534-ep7ezoko	211	6	]	]	-RRB-
cord-316534-ep7ezoko	212	1	[	[	-LRB-
cord-316534-ep7ezoko	212	2	165	165	CD
cord-316534-ep7ezoko	212	3	]	]	-RRB-
cord-316534-ep7ezoko	212	4	[	[	-LRB-
cord-316534-ep7ezoko	212	5	166	166	CD
cord-316534-ep7ezoko	212	6	]	]	-RRB-
cord-316534-ep7ezoko	212	7	[	[	-LRB-
cord-316534-ep7ezoko	212	8	167	167	CD
cord-316534-ep7ezoko	212	9	]	]	-RRB-
cord-316534-ep7ezoko	213	1	Various	various	JJ
cord-316534-ep7ezoko	213	2	strategies	strategy	NNS
cord-316534-ep7ezoko	213	3	have	have	VBP
cord-316534-ep7ezoko	213	4	been	be	VBN
cord-316534-ep7ezoko	213	5	employed	employ	VBN
cord-316534-ep7ezoko	213	6	to	to	TO
cord-316534-ep7ezoko	213	7	circumvent	circumvent	VB
cord-316534-ep7ezoko	213	8	the	the	DT
cord-316534-ep7ezoko	213	9	problems	problem	NNS
cord-316534-ep7ezoko	213	10	associated	associate	VBN
cord-316534-ep7ezoko	213	11	with	with	IN
cord-316534-ep7ezoko	213	12	vector	vector	NN
cord-316534-ep7ezoko	213	13	PEI	PEI	NNP
cord-316534-ep7ezoko	213	14	.	.	.
cord-316534-ep7ezoko	214	1	Specifically	specifically	RB
cord-316534-ep7ezoko	214	2	,	,	,
cord-316534-ep7ezoko	214	3	as	as	IN
cord-316534-ep7ezoko	214	4	it	-PRON-	PRP
cord-316534-ep7ezoko	214	5	relates	relate	VBZ
cord-316534-ep7ezoko	214	6	to	to	IN
cord-316534-ep7ezoko	214	7	Ad	ad	NN
cord-316534-ep7ezoko	214	8	vectors	vector	NNS
cord-316534-ep7ezoko	214	9	,	,	,
cord-316534-ep7ezoko	214	10	PEI	PEI	NNP
cord-316534-ep7ezoko	214	11	is	be	VBZ
cord-316534-ep7ezoko	214	12	a	a	DT
cord-316534-ep7ezoko	214	13	tremendous	tremendous	JJ
cord-316534-ep7ezoko	214	14	problem	problem	NN
cord-316534-ep7ezoko	214	15	.	.	.
cord-316534-ep7ezoko	215	1	Of	of	IN
cord-316534-ep7ezoko	215	2	the	the	DT
cord-316534-ep7ezoko	215	3	identified	identify	VBN
cord-316534-ep7ezoko	215	4	serotypes	serotype	NNS
cord-316534-ep7ezoko	215	5	of	of	IN
cord-316534-ep7ezoko	215	6	Ad	ad	NN
cord-316534-ep7ezoko	215	7	vectors	vector	NNS
cord-316534-ep7ezoko	215	8	,	,	,
cord-316534-ep7ezoko	215	9	human	human	JJ
cord-316534-ep7ezoko	215	10	serotypes	serotype	NNS
cord-316534-ep7ezoko	215	11	5	5	CD
cord-316534-ep7ezoko	215	12	(	(	-LRB-
cord-316534-ep7ezoko	215	13	Ad5	Ad5	NNP
cord-316534-ep7ezoko	215	14	)	)	-RRB-
cord-316534-ep7ezoko	215	15	and	and	CC
cord-316534-ep7ezoko	215	16	2	2	CD
cord-316534-ep7ezoko	215	17	(	(	-LRB-
cord-316534-ep7ezoko	215	18	Ad2	ad2	NN
cord-316534-ep7ezoko	215	19	)	)	-RRB-
cord-316534-ep7ezoko	215	20	have	have	VBP
cord-316534-ep7ezoko	215	21	been	be	VBN
cord-316534-ep7ezoko	215	22	the	the	DT
cord-316534-ep7ezoko	215	23	most	most	RBS
cord-316534-ep7ezoko	215	24	extensively	extensively	RB
cord-316534-ep7ezoko	215	25	used	use	VBN
cord-316534-ep7ezoko	215	26	for	for	IN
cord-316534-ep7ezoko	215	27	gene	gene	NN
cord-316534-ep7ezoko	215	28	therapy	therapy	NN
cord-316534-ep7ezoko	215	29	protocols	protocol	NNS
cord-316534-ep7ezoko	215	30	.	.	.
cord-316534-ep7ezoko	216	1	Ad5	Ad5	NNP
cord-316534-ep7ezoko	216	2	has	have	VBZ
cord-316534-ep7ezoko	216	3	been	be	VBN
cord-316534-ep7ezoko	216	4	used	use	VBN
cord-316534-ep7ezoko	216	5	for	for	IN
cord-316534-ep7ezoko	216	6	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	216	7	vaccination	vaccination	NN
cord-316534-ep7ezoko	216	8	protocols	protocol	NNS
cord-316534-ep7ezoko	216	9	,	,	,
cord-316534-ep7ezoko	216	10	most	most	RBS
cord-316534-ep7ezoko	216	11	recently	recently	RB
cord-316534-ep7ezoko	216	12	in	in	IN
cord-316534-ep7ezoko	216	13	the	the	DT
cord-316534-ep7ezoko	216	14	STEP	STEP	NNP
cord-316534-ep7ezoko	216	15	study	study	NN
cord-316534-ep7ezoko	216	16	.	.	.
cord-316534-ep7ezoko	217	1	As	as	IN
cord-316534-ep7ezoko	217	2	it	-PRON-	PRP
cord-316534-ep7ezoko	217	3	relates	relate	VBZ
cord-316534-ep7ezoko	217	4	to	to	IN
cord-316534-ep7ezoko	217	5	Ad2	ad2	CD
cord-316534-ep7ezoko	217	6	and	and	CC
cord-316534-ep7ezoko	217	7	Ad5	Ad5	NNP
cord-316534-ep7ezoko	217	8	,	,	,
cord-316534-ep7ezoko	217	9	PEI	PEI	NNP
cord-316534-ep7ezoko	217	10	to	to	IN
cord-316534-ep7ezoko	217	11	these	these	DT
cord-316534-ep7ezoko	217	12	vectors	vector	NNS
cord-316534-ep7ezoko	217	13	may	may	MD
cord-316534-ep7ezoko	217	14	be	be	VB
cord-316534-ep7ezoko	217	15	found	find	VBN
cord-316534-ep7ezoko	217	16	in	in	IN
cord-316534-ep7ezoko	217	17	up	up	IN
cord-316534-ep7ezoko	217	18	to	to	TO
cord-316534-ep7ezoko	217	19	50	50	CD
cord-316534-ep7ezoko	217	20	%	%	NN
cord-316534-ep7ezoko	217	21	of	of	IN
cord-316534-ep7ezoko	217	22	the	the	DT
cord-316534-ep7ezoko	217	23	American	american	JJ
cord-316534-ep7ezoko	217	24	population	population	NN
cord-316534-ep7ezoko	217	25	and	and	CC
cord-316534-ep7ezoko	217	26	up	up	IN
cord-316534-ep7ezoko	217	27	to	to	TO
cord-316534-ep7ezoko	217	28	95	95	CD
cord-316534-ep7ezoko	217	29	%	%	NN
cord-316534-ep7ezoko	217	30	of	of	IN
cord-316534-ep7ezoko	217	31	the	the	DT
cord-316534-ep7ezoko	217	32	population	population	NN
cord-316534-ep7ezoko	217	33	of	of	IN
cord-316534-ep7ezoko	217	34	other	other	JJ
cord-316534-ep7ezoko	217	35	countries	country	NNS
cord-316534-ep7ezoko	217	36	.	.	.
cord-316534-ep7ezoko	218	1	This	this	DT
cord-316534-ep7ezoko	218	2	Ad	ad	NN
cord-316534-ep7ezoko	218	3	PEI	PEI	NNP
cord-316534-ep7ezoko	218	4	can	can	MD
cord-316534-ep7ezoko	218	5	limit	limit	VB
cord-316534-ep7ezoko	218	6	the	the	DT
cord-316534-ep7ezoko	218	7	effectiveness	effectiveness	NN
cord-316534-ep7ezoko	218	8	of	of	IN
cord-316534-ep7ezoko	218	9	Ad	ad	NN
cord-316534-ep7ezoko	218	10	-	-	HYPH
cord-316534-ep7ezoko	218	11	based	base	VBN
cord-316534-ep7ezoko	218	12	vaccinations	vaccination	NNS
cord-316534-ep7ezoko	218	13	.	.	.
cord-316534-ep7ezoko	219	1	[	[	-LRB-
cord-316534-ep7ezoko	219	2	168	168	CD
cord-316534-ep7ezoko	219	3	]	]	-RRB-
cord-316534-ep7ezoko	219	4	[	[	-LRB-
cord-316534-ep7ezoko	219	5	169	169	CD
cord-316534-ep7ezoko	219	6	]	]	-RRB-
cord-316534-ep7ezoko	219	7	[	[	-LRB-
cord-316534-ep7ezoko	219	8	170	170	CD
cord-316534-ep7ezoko	219	9	]	]	-RRB-
cord-316534-ep7ezoko	220	1	To	to	TO
cord-316534-ep7ezoko	220	2	circumvent	circumvent	VB
cord-316534-ep7ezoko	220	3	Ad2	ad2	CD
cord-316534-ep7ezoko	220	4	or	or	CC
cord-316534-ep7ezoko	220	5	Ad5	Ad5	NNP
cord-316534-ep7ezoko	220	6	PEI	PEI	NNP
cord-316534-ep7ezoko	220	7	,	,	,
cord-316534-ep7ezoko	220	8	researchers	researcher	NNS
cord-316534-ep7ezoko	220	9	have	have	VBP
cord-316534-ep7ezoko	220	10	employed	employ	VBN
cord-316534-ep7ezoko	220	11	the	the	DT
cord-316534-ep7ezoko	220	12	use	use	NN
cord-316534-ep7ezoko	220	13	of	of	IN
cord-316534-ep7ezoko	220	14	vector	vector	NN
cord-316534-ep7ezoko	220	15	chimeras	chimera	NNS
cord-316534-ep7ezoko	220	16	,	,	,
cord-316534-ep7ezoko	220	17	166,171	166,171	CD
cord-316534-ep7ezoko	220	18	use	use	NN
cord-316534-ep7ezoko	220	19	of	of	IN
cord-316534-ep7ezoko	220	20	alternative	alternative	JJ
cord-316534-ep7ezoko	220	21	serotypes	serotype	NNS
cord-316534-ep7ezoko	220	22	,	,	,
cord-316534-ep7ezoko	220	23	[	[	-LRB-
cord-316534-ep7ezoko	220	24	172	172	CD
cord-316534-ep7ezoko	220	25	]	]	-RRB-
cord-316534-ep7ezoko	220	26	[	[	-LRB-
cord-316534-ep7ezoko	220	27	173	173	CD
cord-316534-ep7ezoko	220	28	]	]	-RRB-
cord-316534-ep7ezoko	220	29	[	[	-LRB-
cord-316534-ep7ezoko	220	30	174	174	CD
cord-316534-ep7ezoko	220	31	]	]	-RRB-
cord-316534-ep7ezoko	220	32	[	[	-LRB-
cord-316534-ep7ezoko	220	33	175	175	CD
cord-316534-ep7ezoko	220	34	]	]	-RRB-
cord-316534-ep7ezoko	220	35	[	[	-LRB-
cord-316534-ep7ezoko	220	36	176	176	CD
cord-316534-ep7ezoko	220	37	]	]	-RRB-
cord-316534-ep7ezoko	220	38	[	[	-LRB-
cord-316534-ep7ezoko	220	39	177	177	CD
cord-316534-ep7ezoko	220	40	]	]	-RRB-
cord-316534-ep7ezoko	220	41	[	[	-LRB-
cord-316534-ep7ezoko	220	42	178	178	CD
cord-316534-ep7ezoko	220	43	]	]	-RRB-
cord-316534-ep7ezoko	220	44	and	and	CC
cord-316534-ep7ezoko	220	45	the	the	DT
cord-316534-ep7ezoko	220	46	use	use	NN
cord-316534-ep7ezoko	220	47	of	of	IN
cord-316534-ep7ezoko	220	48	nonhuman	nonhuman	NN
cord-316534-ep7ezoko	220	49	Ads	ad	NNS
cord-316534-ep7ezoko	220	50	,	,	,
cord-316534-ep7ezoko	220	51	151	151	CD
cord-316534-ep7ezoko	220	52	such	such	JJ
cord-316534-ep7ezoko	220	53	as	as	IN
cord-316534-ep7ezoko	220	54	chimpanzee	chimpanzee	NN
cord-316534-ep7ezoko	220	55	Ad	ad	NN
cord-316534-ep7ezoko	220	56	.	.	.
cord-316534-ep7ezoko	221	1	The	the	DT
cord-316534-ep7ezoko	221	2	chimpanzee	chimpanzee	NN
cord-316534-ep7ezoko	221	3	Ad	ad	NN
cord-316534-ep7ezoko	221	4	virus	virus	NN
cord-316534-ep7ezoko	221	5	was	be	VBD
cord-316534-ep7ezoko	221	6	demonstrated	demonstrate	VBN
cord-316534-ep7ezoko	221	7	to	to	TO
cord-316534-ep7ezoko	221	8	not	not	RB
cord-316534-ep7ezoko	221	9	be	be	VB
cord-316534-ep7ezoko	221	10	significantly	significantly	RB
cord-316534-ep7ezoko	221	11	neutralized	neutralize	VBN
cord-316534-ep7ezoko	221	12	by	by	IN
cord-316534-ep7ezoko	221	13	human	human	JJ
cord-316534-ep7ezoko	221	14	sera	sera	NNP
cord-316534-ep7ezoko	221	15	,	,	,
cord-316534-ep7ezoko	221	16	which	which	WDT
cord-316534-ep7ezoko	221	17	gives	give	VBZ
cord-316534-ep7ezoko	221	18	chimpanzee	chimpanzee	NN
cord-316534-ep7ezoko	221	19	Ad	ad	NN
cord-316534-ep7ezoko	221	20	an	an	DT
cord-316534-ep7ezoko	221	21	advantage	advantage	NN
cord-316534-ep7ezoko	221	22	for	for	IN
cord-316534-ep7ezoko	221	23	human	human	JJ
cord-316534-ep7ezoko	221	24	vaccine	vaccine	NN
cord-316534-ep7ezoko	221	25	development	development	NN
cord-316534-ep7ezoko	221	26	.	.	.
cord-316534-ep7ezoko	222	1	[	[	-LRB-
cord-316534-ep7ezoko	222	2	179	179	CD
cord-316534-ep7ezoko	222	3	]	]	-RRB-
cord-316534-ep7ezoko	222	4	[	[	-LRB-
cord-316534-ep7ezoko	222	5	180	180	CD
cord-316534-ep7ezoko	222	6	]	]	-RRB-
cord-316534-ep7ezoko	223	1	[	[	-LRB-
cord-316534-ep7ezoko	223	2	181	181	CD
cord-316534-ep7ezoko	223	3	]	]	-RRB-
cord-316534-ep7ezoko	224	1	Other	other	JJ
cord-316534-ep7ezoko	224	2	strategies	strategy	NNS
cord-316534-ep7ezoko	224	3	have	have	VBP
cord-316534-ep7ezoko	224	4	been	be	VBN
cord-316534-ep7ezoko	224	5	used	use	VBN
cord-316534-ep7ezoko	224	6	to	to	TO
cord-316534-ep7ezoko	224	7	reduce	reduce	VB
cord-316534-ep7ezoko	224	8	the	the	DT
cord-316534-ep7ezoko	224	9	immune	immune	JJ
cord-316534-ep7ezoko	224	10	response	response	NN
cord-316534-ep7ezoko	224	11	against	against	IN
cord-316534-ep7ezoko	224	12	Ad	ad	NN
cord-316534-ep7ezoko	224	13	vectors	vector	NNS
cord-316534-ep7ezoko	224	14	such	such	JJ
cord-316534-ep7ezoko	224	15	as	as	IN
cord-316534-ep7ezoko	224	16	the	the	DT
cord-316534-ep7ezoko	224	17	use	use	NN
cord-316534-ep7ezoko	224	18	of	of	IN
cord-316534-ep7ezoko	224	19	helperdependent	helperdependent	NN
cord-316534-ep7ezoko	224	20	Ad	ad	NN
cord-316534-ep7ezoko	224	21	(	(	-LRB-
cord-316534-ep7ezoko	224	22	HD	hd	NN
cord-316534-ep7ezoko	224	23	-	-	HYPH
cord-316534-ep7ezoko	224	24	Ads	ad	NNS
cord-316534-ep7ezoko	224	25	)	)	-RRB-
cord-316534-ep7ezoko	224	26	vectors	vector	NNS
cord-316534-ep7ezoko	224	27	,	,	,
cord-316534-ep7ezoko	224	28	182	182	CD
cord-316534-ep7ezoko	224	29	-	-	SYM
cord-316534-ep7ezoko	224	30	187	187	CD
cord-316534-ep7ezoko	224	31	the	the	DT
cord-316534-ep7ezoko	224	32	use	use	NN
cord-316534-ep7ezoko	224	33	of	of	IN
cord-316534-ep7ezoko	224	34	Ad	ad	NN
cord-316534-ep7ezoko	224	35	delivery	delivery	NN
cord-316534-ep7ezoko	224	36	in	in	IN
cord-316534-ep7ezoko	224	37	combination	combination	NN
cord-316534-ep7ezoko	224	38	with	with	IN
cord-316534-ep7ezoko	224	39	biochemical	biochemical	JJ
cord-316534-ep7ezoko	224	40	modifications	modification	NNS
cord-316534-ep7ezoko	224	41	such	such	JJ
cord-316534-ep7ezoko	224	42	as	as	IN
cord-316534-ep7ezoko	224	43	PEGylation	pegylation	NN
cord-316534-ep7ezoko	224	44	,	,	,
cord-316534-ep7ezoko	224	45	[	[	-LRB-
cord-316534-ep7ezoko	224	46	188	188	CD
cord-316534-ep7ezoko	224	47	]	]	-RRB-
cord-316534-ep7ezoko	224	48	[	[	-LRB-
cord-316534-ep7ezoko	224	49	189	189	CD
cord-316534-ep7ezoko	224	50	]	]	-RRB-
cord-316534-ep7ezoko	224	51	[	[	-LRB-
cord-316534-ep7ezoko	224	52	190	190	CD
cord-316534-ep7ezoko	224	53	]	]	-RRB-
cord-316534-ep7ezoko	224	54	[	[	-LRB-
cord-316534-ep7ezoko	224	55	191	191	CD
cord-316534-ep7ezoko	224	56	]	]	-RRB-
cord-316534-ep7ezoko	224	57	[	[	-LRB-
cord-316534-ep7ezoko	224	58	192	192	CD
cord-316534-ep7ezoko	224	59	]	]	-RRB-
cord-316534-ep7ezoko	224	60	[	[	-LRB-
cord-316534-ep7ezoko	224	61	193	193	CD
cord-316534-ep7ezoko	224	62	]	]	-RRB-
cord-316534-ep7ezoko	224	63	[	[	-LRB-
cord-316534-ep7ezoko	224	64	194	194	CD
cord-316534-ep7ezoko	224	65	]	]	-RRB-
cord-316534-ep7ezoko	224	66	and	and	CC
cord-316534-ep7ezoko	224	67	the	the	DT
cord-316534-ep7ezoko	224	68	use	use	NN
cord-316534-ep7ezoko	224	69	of	of	IN
cord-316534-ep7ezoko	224	70	vector	vector	NN
cord-316534-ep7ezoko	224	71	delivery	delivery	NN
cord-316534-ep7ezoko	224	72	by	by	IN
cord-316534-ep7ezoko	224	73	means	mean	NNS
cord-316534-ep7ezoko	224	74	of	of	IN
cord-316534-ep7ezoko	224	75	cell	cell	NN
cord-316534-ep7ezoko	224	76	vehicles	vehicle	NNS
cord-316534-ep7ezoko	224	77	.	.	.
cord-316534-ep7ezoko	225	1	195	195	CD
cord-316534-ep7ezoko	225	2	,	,	,
cord-316534-ep7ezoko	225	3	196	196	CD
cord-316534-ep7ezoko	226	1	With	with	IN
cord-316534-ep7ezoko	226	2	respect	respect	NN
cord-316534-ep7ezoko	226	3	to	to	IN
cord-316534-ep7ezoko	226	4	the	the	DT
cord-316534-ep7ezoko	226	5	HD	hd	NN
cord-316534-ep7ezoko	226	6	-	-	HYPH
cord-316534-ep7ezoko	226	7	Ads	ad	NNS
cord-316534-ep7ezoko	226	8	,	,	,
cord-316534-ep7ezoko	226	9	these	these	DT
cord-316534-ep7ezoko	226	10	vectors	vector	NNS
cord-316534-ep7ezoko	226	11	were	be	VBD
cord-316534-ep7ezoko	226	12	produced	produce	VBN
cord-316534-ep7ezoko	226	13	to	to	TO
cord-316534-ep7ezoko	226	14	further	further	RB
cord-316534-ep7ezoko	226	15	increase	increase	VB
cord-316534-ep7ezoko	226	16	the	the	DT
cord-316534-ep7ezoko	226	17	safety	safety	NN
cord-316534-ep7ezoko	226	18	and	and	CC
cord-316534-ep7ezoko	226	19	cloning	clone	VBG
cord-316534-ep7ezoko	226	20	capacity	capacity	NN
cord-316534-ep7ezoko	226	21	of	of	IN
cord-316534-ep7ezoko	226	22	first	first	JJ
cord-316534-ep7ezoko	226	23	-	-	HYPH
cord-316534-ep7ezoko	226	24	generation	generation	NN
cord-316534-ep7ezoko	226	25	Ad	ad	NN
cord-316534-ep7ezoko	226	26	vectors	vector	NNS
cord-316534-ep7ezoko	226	27	.	.	.
cord-316534-ep7ezoko	227	1	HD	hd	NN
cord-316534-ep7ezoko	227	2	-	-	HYPH
cord-316534-ep7ezoko	227	3	Ads	ad	NNS
cord-316534-ep7ezoko	227	4	lack	lack	VBP
cord-316534-ep7ezoko	227	5	Ad	ad	NN
cord-316534-ep7ezoko	227	6	genes	gene	NNS
cord-316534-ep7ezoko	227	7	and	and	CC
cord-316534-ep7ezoko	227	8	contain	contain	VBP
cord-316534-ep7ezoko	227	9	only	only	RB
cord-316534-ep7ezoko	227	10	the	the	DT
cord-316534-ep7ezoko	227	11	packaging	packaging	NN
cord-316534-ep7ezoko	227	12	signals	signal	NNS
cord-316534-ep7ezoko	227	13	and	and	CC
cord-316534-ep7ezoko	227	14	end	end	VB
cord-316534-ep7ezoko	227	15	terminal	terminal	NN
cord-316534-ep7ezoko	227	16	repeats	repeat	NNS
cord-316534-ep7ezoko	227	17	.	.	.
cord-316534-ep7ezoko	228	1	These	these	DT
cord-316534-ep7ezoko	228	2	vectors	vector	NNS
cord-316534-ep7ezoko	228	3	were	be	VBD
cord-316534-ep7ezoko	228	4	designed	design	VBN
cord-316534-ep7ezoko	228	5	to	to	TO
cord-316534-ep7ezoko	228	6	avoid	avoid	VB
cord-316534-ep7ezoko	228	7	cellular	cellular	JJ
cord-316534-ep7ezoko	228	8	immunity	immunity	NN
cord-316534-ep7ezoko	228	9	and	and	CC
cord-316534-ep7ezoko	228	10	diminish	diminish	VB
cord-316534-ep7ezoko	228	11	liver	liver	NN
cord-316534-ep7ezoko	228	12	toxicity	toxicity	NN
cord-316534-ep7ezoko	228	13	,	,	,
cord-316534-ep7ezoko	228	14	thus	thus	RB
cord-316534-ep7ezoko	228	15	promoting	promote	VBG
cord-316534-ep7ezoko	228	16	long	long	JJ
cord-316534-ep7ezoko	228	17	-	-	HYPH
cord-316534-ep7ezoko	228	18	term	term	NN
cord-316534-ep7ezoko	228	19	transgene	transgene	NN
cord-316534-ep7ezoko	228	20	expression	expression	NN
cord-316534-ep7ezoko	228	21	.	.	.
cord-316534-ep7ezoko	229	1	[	[	-LRB-
cord-316534-ep7ezoko	229	2	197	197	CD
cord-316534-ep7ezoko	229	3	]	]	-RRB-
cord-316534-ep7ezoko	229	4	[	[	-LRB-
cord-316534-ep7ezoko	229	5	198	198	CD
cord-316534-ep7ezoko	229	6	]	]	-RRB-
cord-316534-ep7ezoko	229	7	[	[	-LRB-
cord-316534-ep7ezoko	229	8	199	199	CD
cord-316534-ep7ezoko	229	9	]	]	-RRB-
cord-316534-ep7ezoko	230	1	[	[	-LRB-
cord-316534-ep7ezoko	230	2	200	200	CD
cord-316534-ep7ezoko	230	3	]	]	-RRB-
cord-316534-ep7ezoko	231	1	The	the	DT
cord-316534-ep7ezoko	231	2	reduced	reduce	VBN
cord-316534-ep7ezoko	231	3	immune	immune	JJ
cord-316534-ep7ezoko	231	4	response	response	NN
cord-316534-ep7ezoko	231	5	against	against	IN
cord-316534-ep7ezoko	231	6	HD	hd	NN
cord-316534-ep7ezoko	231	7	-	-	HYPH
cord-316534-ep7ezoko	231	8	Ads	ad	NNS
cord-316534-ep7ezoko	231	9	has	have	VBZ
cord-316534-ep7ezoko	231	10	allowed	allow	VBN
cord-316534-ep7ezoko	231	11	for	for	IN
cord-316534-ep7ezoko	231	12	transgene	transgene	JJ
cord-316534-ep7ezoko	231	13	expression	expression	NN
cord-316534-ep7ezoko	231	14	in	in	IN
cord-316534-ep7ezoko	231	15	mice	mouse	NNS
cord-316534-ep7ezoko	231	16	and	and	CC
cord-316534-ep7ezoko	231	17	baboons	baboon	NNS
cord-316534-ep7ezoko	231	18	for	for	IN
cord-316534-ep7ezoko	231	19	years	year	NNS
cord-316534-ep7ezoko	231	20	.	.	.
cord-316534-ep7ezoko	232	1	182	182	CD
cord-316534-ep7ezoko	232	2	,	,	,
cord-316534-ep7ezoko	232	3	183	183	CD
cord-316534-ep7ezoko	232	4	,	,	,
cord-316534-ep7ezoko	232	5	185	185	CD
cord-316534-ep7ezoko	232	6	,	,	,
cord-316534-ep7ezoko	232	7	200	200	CD
cord-316534-ep7ezoko	232	8	This	this	DT
cord-316534-ep7ezoko	232	9	long	long	JJ
cord-316534-ep7ezoko	232	10	-	-	HYPH
cord-316534-ep7ezoko	232	11	term	term	NN
cord-316534-ep7ezoko	232	12	transgene	transgene	NN
cord-316534-ep7ezoko	232	13	expression	expression	NN
cord-316534-ep7ezoko	232	14	could	could	MD
cord-316534-ep7ezoko	232	15	be	be	VB
cord-316534-ep7ezoko	232	16	helpful	helpful	JJ
cord-316534-ep7ezoko	232	17	for	for	IN
cord-316534-ep7ezoko	232	18	antigen	antigen	NN
cord-316534-ep7ezoko	232	19	production	production	NN
cord-316534-ep7ezoko	232	20	for	for	IN
cord-316534-ep7ezoko	232	21	an	an	DT
cord-316534-ep7ezoko	232	22	HIV	HIV	NNP
cord-316534-ep7ezoko	232	23	vaccine	vaccine	NN
cord-316534-ep7ezoko	232	24	,	,	,
cord-316534-ep7ezoko	232	25	thus	thus	RB
cord-316534-ep7ezoko	232	26	producing	produce	VBG
cord-316534-ep7ezoko	232	27	an	an	DT
cord-316534-ep7ezoko	232	28	opportunity	opportunity	NN
cord-316534-ep7ezoko	232	29	to	to	TO
cord-316534-ep7ezoko	232	30	have	have	VB
cord-316534-ep7ezoko	232	31	increased	increase	VBN
cord-316534-ep7ezoko	232	32	protection	protection	NN
cord-316534-ep7ezoko	232	33	against	against	IN
cord-316534-ep7ezoko	232	34	HIV	HIV	NNP
cord-316534-ep7ezoko	232	35	,	,	,
cord-316534-ep7ezoko	232	36	with	with	IN
cord-316534-ep7ezoko	232	37	reduced	reduce	VBN
cord-316534-ep7ezoko	232	38	frequency	frequency	NN
cord-316534-ep7ezoko	232	39	of	of	IN
cord-316534-ep7ezoko	232	40	vaccinations	vaccination	NNS
cord-316534-ep7ezoko	232	41	.	.	.
cord-316534-ep7ezoko	233	1	Although	although	IN
cord-316534-ep7ezoko	233	2	Nabs	Nabs	NNP
cord-316534-ep7ezoko	233	3	to	to	IN
cord-316534-ep7ezoko	233	4	Ad5	Ad5	NNP
cord-316534-ep7ezoko	233	5	may	may	MD
cord-316534-ep7ezoko	233	6	reduce	reduce	VB
cord-316534-ep7ezoko	233	7	the	the	DT
cord-316534-ep7ezoko	233	8	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	233	9	of	of	IN
cord-316534-ep7ezoko	233	10	Ad5-based	ad5-based	JJ
cord-316534-ep7ezoko	233	11	vectors	vector	NNS
cord-316534-ep7ezoko	233	12	in	in	IN
cord-316534-ep7ezoko	233	13	animal	animal	NN
cord-316534-ep7ezoko	233	14	model	model	NN
cord-316534-ep7ezoko	233	15	systems	system	NNS
cord-316534-ep7ezoko	233	16	,	,	,
cord-316534-ep7ezoko	233	17	their	-PRON-	PRP$
cord-316534-ep7ezoko	233	18	effect	effect	NN
cord-316534-ep7ezoko	233	19	on	on	IN
cord-316534-ep7ezoko	233	20	the	the	DT
cord-316534-ep7ezoko	233	21	immunity	immunity	NN
cord-316534-ep7ezoko	233	22	in	in	IN
cord-316534-ep7ezoko	233	23	subjects	subject	NNS
cord-316534-ep7ezoko	233	24	with	with	IN
cord-316534-ep7ezoko	233	25	previous	previous	JJ
cord-316534-ep7ezoko	233	26	Ad5	ad5	CD
cord-316534-ep7ezoko	233	27	exposure	exposure	NN
cord-316534-ep7ezoko	233	28	is	be	VBZ
cord-316534-ep7ezoko	233	29	still	still	RB
cord-316534-ep7ezoko	233	30	largely	largely	RB
cord-316534-ep7ezoko	233	31	unknown	unknown	JJ
cord-316534-ep7ezoko	233	32	.	.	.
cord-316534-ep7ezoko	234	1	As	as	IN
cord-316534-ep7ezoko	234	2	previously	previously	RB
cord-316534-ep7ezoko	234	3	mentioned	mention	VBN
cord-316534-ep7ezoko	234	4	,	,	,
cord-316534-ep7ezoko	234	5	the	the	DT
cord-316534-ep7ezoko	234	6	STEP	STEP	NNP
cord-316534-ep7ezoko	234	7	trial	trial	NN
cord-316534-ep7ezoko	234	8	,	,	,
cord-316534-ep7ezoko	234	9	which	which	WDT
cord-316534-ep7ezoko	234	10	tested	test	VBD
cord-316534-ep7ezoko	234	11	a	a	DT
cord-316534-ep7ezoko	234	12	Merck	Merck	NNP
cord-316534-ep7ezoko	234	13	recombinant	recombinant	JJ
cord-316534-ep7ezoko	234	14	Ad5	ad5	CD
cord-316534-ep7ezoko	234	15	(	(	-LRB-
cord-316534-ep7ezoko	234	16	rAd5	rAd5	''
cord-316534-ep7ezoko	234	17	)	)	-RRB-
cord-316534-ep7ezoko	234	18	vaccine	vaccine	NN
cord-316534-ep7ezoko	234	19	(	(	-LRB-
cord-316534-ep7ezoko	234	20	encoding	encode	VBG
cord-316534-ep7ezoko	234	21	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	234	22	gag	gag	NN
cord-316534-ep7ezoko	234	23	,	,	,
cord-316534-ep7ezoko	234	24	pol	pol	NN
cord-316534-ep7ezoko	234	25	,	,	,
cord-316534-ep7ezoko	234	26	and	and	CC
cord-316534-ep7ezoko	234	27	ne1	ne1	NN
cord-316534-ep7ezoko	234	28	genes	gene	NNS
cord-316534-ep7ezoko	234	29	)	)	-RRB-
cord-316534-ep7ezoko	234	30	,	,	,
cord-316534-ep7ezoko	234	31	failed	fail	VBD
cord-316534-ep7ezoko	234	32	to	to	TO
cord-316534-ep7ezoko	234	33	yield	yield	VB
cord-316534-ep7ezoko	234	34	protection	protection	NN
cord-316534-ep7ezoko	234	35	,	,	,
cord-316534-ep7ezoko	234	36	either	either	CC
cord-316534-ep7ezoko	234	37	by	by	IN
cord-316534-ep7ezoko	234	38	lowering	lower	VBG
cord-316534-ep7ezoko	234	39	viral	viral	JJ
cord-316534-ep7ezoko	234	40	load	load	NN
cord-316534-ep7ezoko	234	41	or	or	CC
cord-316534-ep7ezoko	234	42	by	by	IN
cord-316534-ep7ezoko	234	43	decreasing	decrease	VBG
cord-316534-ep7ezoko	234	44	acquisition	acquisition	NN
cord-316534-ep7ezoko	234	45	of	of	IN
cord-316534-ep7ezoko	234	46	infection	infection	NN
cord-316534-ep7ezoko	234	47	.	.	.
cord-316534-ep7ezoko	235	1	13	13	CD
cord-316534-ep7ezoko	235	2	Analysis	Analysis	NNP
cord-316534-ep7ezoko	235	3	of	of	IN
cord-316534-ep7ezoko	235	4	data	datum	NNS
cord-316534-ep7ezoko	235	5	from	from	IN
cord-316534-ep7ezoko	235	6	this	this	DT
cord-316534-ep7ezoko	235	7	study	study	NN
cord-316534-ep7ezoko	235	8	aroused	arouse	VBD
cord-316534-ep7ezoko	235	9	speculation	speculation	NN
cord-316534-ep7ezoko	235	10	that	that	IN
cord-316534-ep7ezoko	235	11	subjects	subject	NNS
cord-316534-ep7ezoko	235	12	with	with	IN
cord-316534-ep7ezoko	235	13	pre	pre	JJ
cord-316534-ep7ezoko	235	14	-	-	JJ
cord-316534-ep7ezoko	235	15	existing	existing	JJ
cord-316534-ep7ezoko	235	16	Nabs	Nabs	NNP
cord-316534-ep7ezoko	235	17	from	from	IN
cord-316534-ep7ezoko	235	18	wild	wild	JJ
cord-316534-ep7ezoko	235	19	-	-	HYPH
cord-316534-ep7ezoko	235	20	type	type	NN
cord-316534-ep7ezoko	235	21	Ad5	ad5	CD
cord-316534-ep7ezoko	235	22	infection	infection	NN
cord-316534-ep7ezoko	235	23	had	have	VBD
cord-316534-ep7ezoko	235	24	an	an	DT
cord-316534-ep7ezoko	235	25	increased	increase	VBN
cord-316534-ep7ezoko	235	26	risk	risk	NN
cord-316534-ep7ezoko	235	27	of	of	IN
cord-316534-ep7ezoko	235	28	HIV	HIV	NNP
cord-316534-ep7ezoko	235	29	infection	infection	NN
cord-316534-ep7ezoko	235	30	after	after	IN
cord-316534-ep7ezoko	235	31	vaccination	vaccination	NN
cord-316534-ep7ezoko	235	32	.	.	.
cord-316534-ep7ezoko	236	1	One	one	CD
cord-316534-ep7ezoko	236	2	recent	recent	JJ
cord-316534-ep7ezoko	236	3	study	study	NN
cord-316534-ep7ezoko	236	4	has	have	VBZ
cord-316534-ep7ezoko	236	5	shown	show	VBN
cord-316534-ep7ezoko	236	6	that	that	IN
cord-316534-ep7ezoko	236	7	there	there	EX
cord-316534-ep7ezoko	236	8	was	be	VBD
cord-316534-ep7ezoko	236	9	no	no	DT
cord-316534-ep7ezoko	236	10	causative	causative	JJ
cord-316534-ep7ezoko	236	11	role	role	NN
cord-316534-ep7ezoko	236	12	for	for	IN
cord-316534-ep7ezoko	236	13	Ad5-specific	Ad5-specific	NNP
cord-316534-ep7ezoko	236	14	CD4	CD4	NNP
cord-316534-ep7ezoko	236	15	+	+	CC
cord-316534-ep7ezoko	236	16	T	t	NN
cord-316534-ep7ezoko	236	17	cells	cell	NNS
cord-316534-ep7ezoko	236	18	in	in	IN
cord-316534-ep7ezoko	236	19	increasing	increase	VBG
cord-316534-ep7ezoko	236	20	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	236	21	susceptibility	susceptibility	NN
cord-316534-ep7ezoko	236	22	in	in	IN
cord-316534-ep7ezoko	236	23	the	the	DT
cord-316534-ep7ezoko	236	24	Merck	Merck	NNP
cord-316534-ep7ezoko	236	25	trial	trial	NN
cord-316534-ep7ezoko	236	26	.	.	.
cord-316534-ep7ezoko	237	1	201	201	CD
cord-316534-ep7ezoko	238	1	In	in	IN
cord-316534-ep7ezoko	238	2	this	this	DT
cord-316534-ep7ezoko	238	3	regard	regard	NN
cord-316534-ep7ezoko	238	4	,	,	,
cord-316534-ep7ezoko	238	5	there	there	EX
cord-316534-ep7ezoko	238	6	are	be	VBP
cord-316534-ep7ezoko	238	7	multiple	multiple	JJ
cord-316534-ep7ezoko	238	8	studies	study	NNS
cord-316534-ep7ezoko	238	9	ongoing	ongoing	JJ
cord-316534-ep7ezoko	238	10	to	to	TO
cord-316534-ep7ezoko	238	11	elucidate	elucidate	VB
cord-316534-ep7ezoko	238	12	a	a	DT
cord-316534-ep7ezoko	238	13	concrete	concrete	JJ
cord-316534-ep7ezoko	238	14	finding	finding	NN
cord-316534-ep7ezoko	238	15	with	with	IN
cord-316534-ep7ezoko	238	16	respect	respect	NN
cord-316534-ep7ezoko	238	17	to	to	IN
cord-316534-ep7ezoko	238	18	the	the	DT
cord-316534-ep7ezoko	238	19	role	role	NN
cord-316534-ep7ezoko	238	20	of	of	IN
cord-316534-ep7ezoko	238	21	Ad5	ad5	CD
cord-316534-ep7ezoko	238	22	PEI	PEI	NNP
cord-316534-ep7ezoko	238	23	and	and	CC
cord-316534-ep7ezoko	238	24	increased	increase	VBN
cord-316534-ep7ezoko	238	25	activation	activation	NN
cord-316534-ep7ezoko	238	26	of	of	IN
cord-316534-ep7ezoko	238	27	CD4	CD4	NNP
cord-316534-ep7ezoko	238	28	+	+	CC
cord-316534-ep7ezoko	238	29	T	T	NNP
cord-316534-ep7ezoko	238	30	cells	cell	NNS
cord-316534-ep7ezoko	238	31	in	in	IN
cord-316534-ep7ezoko	238	32	the	the	DT
cord-316534-ep7ezoko	238	33	mucosal	mucosal	JJ
cord-316534-ep7ezoko	238	34	milieu	milieu	NN
cord-316534-ep7ezoko	238	35	.	.	.
cord-316534-ep7ezoko	239	1	202	202	CD
cord-316534-ep7ezoko	239	2	,	,	,
cord-316534-ep7ezoko	239	3	203	203	CD
cord-316534-ep7ezoko	239	4	Recently	recently	RB
cord-316534-ep7ezoko	239	5	,	,	,
cord-316534-ep7ezoko	239	6	there	there	EX
cord-316534-ep7ezoko	239	7	was	be	VBD
cord-316534-ep7ezoko	239	8	a	a	DT
cord-316534-ep7ezoko	239	9	report	report	NN
cord-316534-ep7ezoko	239	10	by	by	IN
cord-316534-ep7ezoko	239	11	Cheng	Cheng	NNP
cord-316534-ep7ezoko	239	12	and	and	CC
cord-316534-ep7ezoko	239	13	colleagues	colleague	NNS
cord-316534-ep7ezoko	239	14	that	that	WDT
cord-316534-ep7ezoko	239	15	attempted	attempt	VBD
cord-316534-ep7ezoko	239	16	to	to	TO
cord-316534-ep7ezoko	239	17	characterize	characterize	VB
cord-316534-ep7ezoko	239	18	the	the	DT
cord-316534-ep7ezoko	239	19	specificity	specificity	NN
cord-316534-ep7ezoko	239	20	of	of	IN
cord-316534-ep7ezoko	239	21	rAd5	rAd5	``
cord-316534-ep7ezoko	239	22	Nabs	Nabs	NNP
cord-316534-ep7ezoko	239	23	in	in	IN
cord-316534-ep7ezoko	239	24	Ad5immune	Ad5immune	NNP
cord-316534-ep7ezoko	239	25	subjects	subject	NNS
cord-316534-ep7ezoko	239	26	and	and	CC
cord-316534-ep7ezoko	239	27	determine	determine	VB
cord-316534-ep7ezoko	239	28	the	the	DT
cord-316534-ep7ezoko	239	29	impact	impact	NN
cord-316534-ep7ezoko	239	30	of	of	IN
cord-316534-ep7ezoko	239	31	Ad	ad	NN
cord-316534-ep7ezoko	239	32	exposure	exposure	NN
cord-316534-ep7ezoko	239	33	on	on	IN
cord-316534-ep7ezoko	239	34	immune	immune	JJ
cord-316534-ep7ezoko	239	35	responses	response	NNS
cord-316534-ep7ezoko	239	36	elicited	elicit	VBN
cord-316534-ep7ezoko	239	37	by	by	IN
cord-316534-ep7ezoko	239	38	Ad5-based	ad5-based	JJ
cord-316534-ep7ezoko	239	39	vaccinations	vaccination	NNS
cord-316534-ep7ezoko	239	40	.	.	.
cord-316534-ep7ezoko	240	1	Cheng	Cheng	NNP
cord-316534-ep7ezoko	240	2	and	and	CC
cord-316534-ep7ezoko	240	3	colleagues	colleague	NNS
cord-316534-ep7ezoko	240	4	reported	report	VBD
cord-316534-ep7ezoko	240	5	that	that	IN
cord-316534-ep7ezoko	240	6	rAd5	rAd5	``
cord-316534-ep7ezoko	240	7	Nabs	Nabs	NNP
cord-316534-ep7ezoko	240	8	were	be	VBD
cord-316534-ep7ezoko	240	9	directed	direct	VBN
cord-316534-ep7ezoko	240	10	toward	toward	IN
cord-316534-ep7ezoko	240	11	different	different	JJ
cord-316534-ep7ezoko	240	12	components	component	NNS
cord-316534-ep7ezoko	240	13	of	of	IN
cord-316534-ep7ezoko	240	14	the	the	DT
cord-316534-ep7ezoko	240	15	Ad	ad	NN
cord-316534-ep7ezoko	240	16	virion	virion	NN
cord-316534-ep7ezoko	240	17	,	,	,
cord-316534-ep7ezoko	240	18	depending	depend	VBG
cord-316534-ep7ezoko	240	19	on	on	IN
cord-316534-ep7ezoko	240	20	whether	whether	IN
cord-316534-ep7ezoko	240	21	the	the	DT
cord-316534-ep7ezoko	240	22	Ad5	ad5	CD
cord-316534-ep7ezoko	240	23	infection	infection	NN
cord-316534-ep7ezoko	240	24	was	be	VBD
cord-316534-ep7ezoko	240	25	natural	natural	JJ
cord-316534-ep7ezoko	240	26	or	or	CC
cord-316534-ep7ezoko	240	27	from	from	IN
cord-316534-ep7ezoko	240	28	Ad	ad	NN
cord-316534-ep7ezoko	240	29	-	-	HYPH
cord-316534-ep7ezoko	240	30	based	base	VBN
cord-316534-ep7ezoko	240	31	HIV	HIV	NNP
cord-316534-ep7ezoko	240	32	vaccine	vaccine	NN
cord-316534-ep7ezoko	240	33	trials	trial	NNS
cord-316534-ep7ezoko	240	34	.	.	.
cord-316534-ep7ezoko	241	1	For	for	IN
cord-316534-ep7ezoko	241	2	example	example	NN
cord-316534-ep7ezoko	241	3	,	,	,
cord-316534-ep7ezoko	241	4	Ad	Ad	NNP
cord-316534-ep7ezoko	241	5	Nabs	Nabs	NNP
cord-316534-ep7ezoko	241	6	generated	generate	VBN
cord-316534-ep7ezoko	241	7	by	by	IN
cord-316534-ep7ezoko	241	8	natural	natural	JJ
cord-316534-ep7ezoko	241	9	infection	infection	NN
cord-316534-ep7ezoko	241	10	are	be	VBP
cord-316534-ep7ezoko	241	11	directed	direct	VBN
cord-316534-ep7ezoko	241	12	primarily	primarily	RB
cord-316534-ep7ezoko	241	13	to	to	TO
cord-316534-ep7ezoko	241	14	fiber	fiber	VB
cord-316534-ep7ezoko	241	15	components	component	NNS
cord-316534-ep7ezoko	241	16	,	,	,
cord-316534-ep7ezoko	241	17	while	while	IN
cord-316534-ep7ezoko	241	18	vector	vector	NN
cord-316534-ep7ezoko	241	19	exposure	exposure	NN
cord-316534-ep7ezoko	241	20	elicits	elicit	VBZ
cord-316534-ep7ezoko	241	21	responses	response	NNS
cord-316534-ep7ezoko	241	22	primarily	primarily	RB
cord-316534-ep7ezoko	241	23	to	to	IN
cord-316534-ep7ezoko	241	24	capsid	capsid	NN
cord-316534-ep7ezoko	241	25	proteins	protein	NNS
cord-316534-ep7ezoko	241	26	other	other	JJ
cord-316534-ep7ezoko	241	27	than	than	IN
cord-316534-ep7ezoko	241	28	fiber	fiber	NN
cord-316534-ep7ezoko	241	29	.	.	.
cord-316534-ep7ezoko	242	1	Nabs	Nabs	NNP
cord-316534-ep7ezoko	242	2	elicited	elicit	VBN
cord-316534-ep7ezoko	242	3	by	by	IN
cord-316534-ep7ezoko	242	4	natural	natural	JJ
cord-316534-ep7ezoko	242	5	infection	infection	NN
cord-316534-ep7ezoko	242	6	significantly	significantly	RB
cord-316534-ep7ezoko	242	7	reduced	reduce	VBD
cord-316534-ep7ezoko	242	8	the	the	DT
cord-316534-ep7ezoko	242	9	CD8	CD8	NNP
cord-316534-ep7ezoko	242	10	+	+	SYM
cord-316534-ep7ezoko	242	11	and	and	CC
cord-316534-ep7ezoko	242	12	CD4	CD4	NNP
cord-316534-ep7ezoko	242	13	+	+	CC
cord-316534-ep7ezoko	242	14	cell	cell	NN
cord-316534-ep7ezoko	242	15	responses	response	NNS
cord-316534-ep7ezoko	242	16	to	to	IN
cord-316534-ep7ezoko	242	17	HIV	HIV	NNP
cord-316534-ep7ezoko	242	18	Gag	Gag	NNP
cord-316534-ep7ezoko	242	19	after	after	IN
cord-316534-ep7ezoko	242	20	DNA	DNA	NNP
cord-316534-ep7ezoko	242	21	/	/	SYM
cord-316534-ep7ezoko	242	22	rAd5	rAd5	NNP
cord-316534-ep7ezoko	242	23	vaccination	vaccination	NN
cord-316534-ep7ezoko	242	24	.	.	.
cord-316534-ep7ezoko	243	1	This	this	DT
cord-316534-ep7ezoko	243	2	report	report	NN
cord-316534-ep7ezoko	243	3	concluded	conclude	VBD
cord-316534-ep7ezoko	243	4	that	that	IN
cord-316534-ep7ezoko	243	5	Ad5	ad5	CD
cord-316534-ep7ezoko	243	6	Nabs	Nabs	NNP
cord-316534-ep7ezoko	243	7	differ	differ	VBP
cord-316534-ep7ezoko	243	8	based	base	VBN
cord-316534-ep7ezoko	243	9	on	on	IN
cord-316534-ep7ezoko	243	10	the	the	DT
cord-316534-ep7ezoko	243	11	route	route	NN
cord-316534-ep7ezoko	243	12	of	of	IN
cord-316534-ep7ezoko	243	13	exposure	exposure	NN
cord-316534-ep7ezoko	243	14	and	and	CC
cord-316534-ep7ezoko	243	15	that	that	IN
cord-316534-ep7ezoko	243	16	previous	previous	JJ
cord-316534-ep7ezoko	243	17	Ad5	ad5	CD
cord-316534-ep7ezoko	243	18	exposure	exposure	NN
cord-316534-ep7ezoko	243	19	compromises	compromise	VBZ
cord-316534-ep7ezoko	243	20	Ad5	Ad5	NNP
cord-316534-ep7ezoko	243	21	vaccine	vaccine	NN
cord-316534-ep7ezoko	243	22	-	-	HYPH
cord-316534-ep7ezoko	243	23	induced	induce	VBN
cord-316534-ep7ezoko	243	24	immunity	immunity	NN
cord-316534-ep7ezoko	243	25	to	to	IN
cord-316534-ep7ezoko	243	26	weak	weak	JJ
cord-316534-ep7ezoko	243	27	immunogens	immunogen	NNS
cord-316534-ep7ezoko	243	28	,	,	,
cord-316534-ep7ezoko	243	29	such	such	JJ
cord-316534-ep7ezoko	243	30	as	as	IN
cord-316534-ep7ezoko	243	31	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	243	32	Gag	Gag	NNP
cord-316534-ep7ezoko	243	33	.	.	.
cord-316534-ep7ezoko	244	1	204	204	CD
cord-316534-ep7ezoko	245	1	These	these	DT
cord-316534-ep7ezoko	245	2	results	result	NNS
cord-316534-ep7ezoko	245	3	have	have	VBP
cord-316534-ep7ezoko	245	4	a	a	DT
cord-316534-ep7ezoko	245	5	tremendous	tremendous	JJ
cord-316534-ep7ezoko	245	6	impact	impact	NN
cord-316534-ep7ezoko	245	7	on	on	IN
cord-316534-ep7ezoko	245	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	245	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	245	10	trials	trial	NNS
cord-316534-ep7ezoko	245	11	and	and	CC
cord-316534-ep7ezoko	245	12	the	the	DT
cord-316534-ep7ezoko	245	13	design	design	NN
cord-316534-ep7ezoko	245	14	of	of	IN
cord-316534-ep7ezoko	245	15	next	next	JJ
cord-316534-ep7ezoko	245	16	generation	generation	NN
cord-316534-ep7ezoko	245	17	viral	viral	JJ
cord-316534-ep7ezoko	245	18	vaccine	vaccine	NN
cord-316534-ep7ezoko	245	19	vectors	vector	NNS
cord-316534-ep7ezoko	245	20	.	.	.
cord-316534-ep7ezoko	246	1	Viral	viral	JJ
cord-316534-ep7ezoko	246	2	vectors	vector	NNS
cord-316534-ep7ezoko	246	3	such	such	JJ
cord-316534-ep7ezoko	246	4	as	as	IN
cord-316534-ep7ezoko	246	5	Ad	ad	NN
cord-316534-ep7ezoko	246	6	,	,	,
cord-316534-ep7ezoko	246	7	influenza	influenza	NN
cord-316534-ep7ezoko	246	8	,	,	,
cord-316534-ep7ezoko	246	9	and	and	CC
cord-316534-ep7ezoko	246	10	polio	polio	NN
cord-316534-ep7ezoko	246	11	have	have	VBP
cord-316534-ep7ezoko	246	12	been	be	VBN
cord-316534-ep7ezoko	246	13	used	use	VBN
cord-316534-ep7ezoko	246	14	as	as	IN
cord-316534-ep7ezoko	246	15	vaccine	vaccine	NN
cord-316534-ep7ezoko	246	16	vectors	vector	NNS
cord-316534-ep7ezoko	246	17	for	for	IN
cord-316534-ep7ezoko	246	18	many	many	JJ
cord-316534-ep7ezoko	246	19	reasons	reason	NNS
cord-316534-ep7ezoko	246	20	.	.	.
cord-316534-ep7ezoko	247	1	One	one	CD
cord-316534-ep7ezoko	247	2	important	important	JJ
cord-316534-ep7ezoko	247	3	advantage	advantage	NN
cord-316534-ep7ezoko	247	4	of	of	IN
cord-316534-ep7ezoko	247	5	these	these	DT
cord-316534-ep7ezoko	247	6	vectors	vector	NNS
cord-316534-ep7ezoko	247	7	,	,	,
cord-316534-ep7ezoko	247	8	which	which	WDT
cord-316534-ep7ezoko	247	9	makes	make	VBZ
cord-316534-ep7ezoko	247	10	them	-PRON-	PRP
cord-316534-ep7ezoko	247	11	attractive	attractive	JJ
cord-316534-ep7ezoko	247	12	,	,	,
cord-316534-ep7ezoko	247	13	is	be	VBZ
cord-316534-ep7ezoko	247	14	that	that	IN
cord-316534-ep7ezoko	247	15	they	-PRON-	PRP
cord-316534-ep7ezoko	247	16	can	can	MD
cord-316534-ep7ezoko	247	17	provide	provide	VB
cord-316534-ep7ezoko	247	18	mucosal	mucosal	JJ
cord-316534-ep7ezoko	247	19	immunity	immunity	NN
cord-316534-ep7ezoko	247	20	because	because	IN
cord-316534-ep7ezoko	247	21	they	-PRON-	PRP
cord-316534-ep7ezoko	247	22	can	can	MD
cord-316534-ep7ezoko	247	23	easily	easily	RB
cord-316534-ep7ezoko	247	24	infect	infect	VB
cord-316534-ep7ezoko	247	25	the	the	DT
cord-316534-ep7ezoko	247	26	mucosal	mucosal	JJ
cord-316534-ep7ezoko	247	27	surfaces	surface	NNS
cord-316534-ep7ezoko	247	28	as	as	RB
cord-316534-ep7ezoko	247	29	well	well	RB
cord-316534-ep7ezoko	247	30	as	as	IN
cord-316534-ep7ezoko	247	31	act	act	NN
cord-316534-ep7ezoko	247	32	to	to	TO
cord-316534-ep7ezoko	247	33	induce	induce	VB
cord-316534-ep7ezoko	247	34	cytokine	cytokine	NN
cord-316534-ep7ezoko	247	35	and	and	CC
cord-316534-ep7ezoko	247	36	chemokine	chemokine	NN
cord-316534-ep7ezoko	247	37	production	production	NN
cord-316534-ep7ezoko	247	38	at	at	IN
cord-316534-ep7ezoko	247	39	the	the	DT
cord-316534-ep7ezoko	247	40	mucosal	mucosal	JJ
cord-316534-ep7ezoko	247	41	entry	entry	NN
cord-316534-ep7ezoko	247	42	sites	site	NNS
cord-316534-ep7ezoko	247	43	.	.	.
cord-316534-ep7ezoko	248	1	Ad	ad	NN
cord-316534-ep7ezoko	248	2	,	,	,
cord-316534-ep7ezoko	248	3	influenza	influenza	NN
cord-316534-ep7ezoko	248	4	,	,	,
cord-316534-ep7ezoko	248	5	and	and	CC
cord-316534-ep7ezoko	248	6	polio	polio	NN
cord-316534-ep7ezoko	248	7	also	also	RB
cord-316534-ep7ezoko	248	8	have	have	VBP
cord-316534-ep7ezoko	248	9	the	the	DT
cord-316534-ep7ezoko	248	10	advantage	advantage	NN
cord-316534-ep7ezoko	248	11	of	of	IN
cord-316534-ep7ezoko	248	12	being	be	VBG
cord-316534-ep7ezoko	248	13	able	able	JJ
cord-316534-ep7ezoko	248	14	to	to	TO
cord-316534-ep7ezoko	248	15	be	be	VB
cord-316534-ep7ezoko	248	16	delivered	deliver	VBN
cord-316534-ep7ezoko	248	17	orally	orally	RB
cord-316534-ep7ezoko	248	18	,	,	,
cord-316534-ep7ezoko	248	19	without	without	IN
cord-316534-ep7ezoko	248	20	the	the	DT
cord-316534-ep7ezoko	248	21	use	use	NN
cord-316534-ep7ezoko	248	22	of	of	IN
cord-316534-ep7ezoko	248	23	needles	needle	NNS
cord-316534-ep7ezoko	248	24	.	.	.
cord-316534-ep7ezoko	249	1	This	this	DT
cord-316534-ep7ezoko	249	2	is	be	VBZ
cord-316534-ep7ezoko	249	3	an	an	DT
cord-316534-ep7ezoko	249	4	important	important	JJ
cord-316534-ep7ezoko	249	5	fact	fact	NN
cord-316534-ep7ezoko	249	6	in	in	IN
cord-316534-ep7ezoko	249	7	developing	develop	VBG
cord-316534-ep7ezoko	249	8	countries	country	NNS
cord-316534-ep7ezoko	249	9	where	where	WRB
cord-316534-ep7ezoko	249	10	needle	needle	NN
cord-316534-ep7ezoko	249	11	cost	cost	NN
cord-316534-ep7ezoko	249	12	is	be	VBZ
cord-316534-ep7ezoko	249	13	prohibitive	prohibitive	JJ
cord-316534-ep7ezoko	249	14	to	to	IN
cord-316534-ep7ezoko	249	15	vaccine	vaccine	NN
cord-316534-ep7ezoko	249	16	administration	administration	NN
cord-316534-ep7ezoko	249	17	.	.	.
cord-316534-ep7ezoko	250	1	As	as	IN
cord-316534-ep7ezoko	250	2	it	-PRON-	PRP
cord-316534-ep7ezoko	250	3	relates	relate	VBZ
cord-316534-ep7ezoko	250	4	to	to	IN
cord-316534-ep7ezoko	250	5	HIV	HIV	NNP
cord-316534-ep7ezoko	250	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	250	7	development	development	NN
cord-316534-ep7ezoko	250	8	,	,	,
cord-316534-ep7ezoko	250	9	mucosal	mucosal	JJ
cord-316534-ep7ezoko	250	10	immunity	immunity	NN
cord-316534-ep7ezoko	250	11	is	be	VBZ
cord-316534-ep7ezoko	250	12	a	a	DT
cord-316534-ep7ezoko	250	13	debatable	debatable	JJ
cord-316534-ep7ezoko	250	14	factor	factor	NN
cord-316534-ep7ezoko	250	15	to	to	TO
cord-316534-ep7ezoko	250	16	consider	consider	VB
cord-316534-ep7ezoko	250	17	.	.	.
cord-316534-ep7ezoko	251	1	When	when	WRB
cord-316534-ep7ezoko	251	2	deciding	decide	VBG
cord-316534-ep7ezoko	251	3	upon	upon	IN
cord-316534-ep7ezoko	251	4	a	a	DT
cord-316534-ep7ezoko	251	5	vaccine	vaccine	NN
cord-316534-ep7ezoko	251	6	agent	agent	NN
cord-316534-ep7ezoko	251	7	,	,	,
cord-316534-ep7ezoko	251	8	the	the	DT
cord-316534-ep7ezoko	251	9	importance	importance	NN
cord-316534-ep7ezoko	251	10	of	of	IN
cord-316534-ep7ezoko	251	11	considering	consider	VBG
cord-316534-ep7ezoko	251	12	if	if	IN
cord-316534-ep7ezoko	251	13	the	the	DT
cord-316534-ep7ezoko	251	14	ultimate	ultimate	JJ
cord-316534-ep7ezoko	251	15	goal	goal	NN
cord-316534-ep7ezoko	251	16	is	be	VBZ
cord-316534-ep7ezoko	251	17	to	to	TO
cord-316534-ep7ezoko	251	18	induce	induce	VB
cord-316534-ep7ezoko	251	19	systemic	systemic	JJ
cord-316534-ep7ezoko	251	20	immunity	immunity	NN
cord-316534-ep7ezoko	251	21	,	,	,
cord-316534-ep7ezoko	251	22	mucosal	mucosal	JJ
cord-316534-ep7ezoko	251	23	immunity	immunity	NN
cord-316534-ep7ezoko	251	24	,	,	,
cord-316534-ep7ezoko	251	25	or	or	CC
cord-316534-ep7ezoko	251	26	both	both	DT
cord-316534-ep7ezoko	251	27	is	be	VBZ
cord-316534-ep7ezoko	251	28	worth	worth	JJ
cord-316534-ep7ezoko	251	29	careful	careful	JJ
cord-316534-ep7ezoko	251	30	consideration	consideration	NN
cord-316534-ep7ezoko	251	31	.	.	.
cord-316534-ep7ezoko	252	1	[	[	-LRB-
cord-316534-ep7ezoko	252	2	205	205	CD
cord-316534-ep7ezoko	252	3	]	]	-RRB-
cord-316534-ep7ezoko	252	4	[	[	-LRB-
cord-316534-ep7ezoko	252	5	206	206	CD
cord-316534-ep7ezoko	252	6	]	]	-RRB-
cord-316534-ep7ezoko	253	1	[	[	-LRB-
cord-316534-ep7ezoko	253	2	207	207	CD
cord-316534-ep7ezoko	253	3	]	]	-RRB-
cord-316534-ep7ezoko	254	1	It	-PRON-	PRP
cord-316534-ep7ezoko	254	2	is	be	VBZ
cord-316534-ep7ezoko	254	3	believed	believe	VBN
cord-316534-ep7ezoko	254	4	that	that	IN
cord-316534-ep7ezoko	254	5	80	80	CD
cord-316534-ep7ezoko	254	6	%	%	NN
cord-316534-ep7ezoko	254	7	of	of	IN
cord-316534-ep7ezoko	254	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	254	9	i	i	PRP
cord-316534-ep7ezoko	254	10	nfection	nfection	NN
cord-316534-ep7ezoko	254	11	will	will	MD
cord-316534-ep7ezoko	254	12	occur	occur	VB
cord-316534-ep7ezoko	254	13	from	from	IN
cord-316534-ep7ezoko	254	14	heterosexual	heterosexual	JJ
cord-316534-ep7ezoko	254	15	viral	viral	JJ
cord-316534-ep7ezoko	254	16	transmission	transmission	NN
cord-316534-ep7ezoko	254	17	and	and	CC
cord-316534-ep7ezoko	254	18	most	most	JJS
cord-316534-ep7ezoko	254	19	of	of	IN
cord-316534-ep7ezoko	254	20	the	the	DT
cord-316534-ep7ezoko	254	21	rest	rest	NN
cord-316534-ep7ezoko	254	22	will	will	MD
cord-316534-ep7ezoko	254	23	occur	occur	VB
cord-316534-ep7ezoko	254	24	from	from	IN
cord-316534-ep7ezoko	254	25	homosexual	homosexual	JJ
cord-316534-ep7ezoko	254	26	or	or	CC
cord-316534-ep7ezoko	254	27	perinatal	perinatal	JJ
cord-316534-ep7ezoko	254	28	transmission	transmission	NN
cord-316534-ep7ezoko	254	29	.	.	.
cord-316534-ep7ezoko	255	1	152	152	CD
cord-316534-ep7ezoko	256	1	Although	although	IN
cord-316534-ep7ezoko	256	2	the	the	DT
cord-316534-ep7ezoko	256	3	biology	biology	NN
cord-316534-ep7ezoko	256	4	of	of	IN
cord-316534-ep7ezoko	256	5	sexual	sexual	JJ
cord-316534-ep7ezoko	256	6	transmission	transmission	NN
cord-316534-ep7ezoko	256	7	is	be	VBZ
cord-316534-ep7ezoko	256	8	poorly	poorly	RB
cord-316534-ep7ezoko	256	9	understood	understand	VBN
cord-316534-ep7ezoko	256	10	,	,	,
cord-316534-ep7ezoko	256	11	it	-PRON-	PRP
cord-316534-ep7ezoko	256	12	is	be	VBZ
cord-316534-ep7ezoko	256	13	clear	clear	JJ
cord-316534-ep7ezoko	256	14	that	that	IN
cord-316534-ep7ezoko	256	15	the	the	DT
cord-316534-ep7ezoko	256	16	essential	essential	JJ
cord-316534-ep7ezoko	256	17	first	first	JJ
cord-316534-ep7ezoko	256	18	step	step	NN
cord-316534-ep7ezoko	256	19	in	in	IN
cord-316534-ep7ezoko	256	20	the	the	DT
cord-316534-ep7ezoko	256	21	infection	infection	NN
cord-316534-ep7ezoko	256	22	pathway	pathway	NN
cord-316534-ep7ezoko	256	23	is	be	VBZ
cord-316534-ep7ezoko	256	24	the	the	DT
cord-316534-ep7ezoko	256	25	transfer	transfer	NN
cord-316534-ep7ezoko	256	26	of	of	IN
cord-316534-ep7ezoko	256	27	infectious	infectious	JJ
cord-316534-ep7ezoko	256	28	virus	virus	NN
cord-316534-ep7ezoko	256	29	or	or	CC
cord-316534-ep7ezoko	256	30	HIV	HIV	NNP
cord-316534-ep7ezoko	256	31	-	-	HYPH
cord-316534-ep7ezoko	256	32	infected	infect	VBN
cord-316534-ep7ezoko	256	33	cells	cell	NNS
cord-316534-ep7ezoko	256	34	through	through	IN
cord-316534-ep7ezoko	256	35	the	the	DT
cord-316534-ep7ezoko	256	36	mucosal	mucosal	JJ
cord-316534-ep7ezoko	256	37	surfaces	surface	NNS
cord-316534-ep7ezoko	256	38	.	.	.
cord-316534-ep7ezoko	257	1	After	after	IN
cord-316534-ep7ezoko	257	2	HIV	HIV	NNP
cord-316534-ep7ezoko	257	3	has	have	VBZ
cord-316534-ep7ezoko	257	4	entered	enter	VBN
cord-316534-ep7ezoko	257	5	a	a	DT
cord-316534-ep7ezoko	257	6	new	new	JJ
cord-316534-ep7ezoko	257	7	host	host	NN
cord-316534-ep7ezoko	257	8	,	,	,
cord-316534-ep7ezoko	257	9	the	the	DT
cord-316534-ep7ezoko	257	10	HIV	HIV	NNP
cord-316534-ep7ezoko	257	11	or	or	CC
cord-316534-ep7ezoko	257	12	HIV	HIV	NNP
cord-316534-ep7ezoko	257	13	-	-	HYPH
cord-316534-ep7ezoko	257	14	infected	infect	VBN
cord-316534-ep7ezoko	257	15	cells	cell	NNS
cord-316534-ep7ezoko	257	16	will	will	MD
cord-316534-ep7ezoko	257	17	soon	soon	RB
cord-316534-ep7ezoko	257	18	encounter	encounter	VB
cord-316534-ep7ezoko	257	19	susceptible	susceptible	JJ
cord-316534-ep7ezoko	257	20	host	host	NN
cord-316534-ep7ezoko	257	21	target	target	NN
cord-316534-ep7ezoko	257	22	cells	cell	NNS
cord-316534-ep7ezoko	257	23	at	at	IN
cord-316534-ep7ezoko	257	24	the	the	DT
cord-316534-ep7ezoko	257	25	mucosal	mucosal	JJ
cord-316534-ep7ezoko	257	26	point	point	NN
cord-316534-ep7ezoko	257	27	of	of	IN
cord-316534-ep7ezoko	257	28	entry	entry	NN
cord-316534-ep7ezoko	257	29	where	where	WRB
cord-316534-ep7ezoko	257	30	the	the	DT
cord-316534-ep7ezoko	257	31	virus	virus	NN
cord-316534-ep7ezoko	257	32	replicates	replicate	VBZ
cord-316534-ep7ezoko	257	33	and	and	CC
cord-316534-ep7ezoko	257	34	then	then	RB
cord-316534-ep7ezoko	257	35	invades	invade	VBZ
cord-316534-ep7ezoko	257	36	local	local	JJ
cord-316534-ep7ezoko	257	37	lymphatic	lymphatic	JJ
cord-316534-ep7ezoko	257	38	tissues	tissue	NNS
cord-316534-ep7ezoko	257	39	,	,	,
cord-316534-ep7ezoko	257	40	initiating	initiate	VBG
cord-316534-ep7ezoko	257	41	systemic	systemic	JJ
cord-316534-ep7ezoko	257	42	HIV	HIV	NNP
cord-316534-ep7ezoko	257	43	infection	infection	NN
cord-316534-ep7ezoko	257	44	.	.	.
cord-316534-ep7ezoko	258	1	On	on	IN
cord-316534-ep7ezoko	258	2	this	this	DT
cord-316534-ep7ezoko	258	3	basis	basis	NN
cord-316534-ep7ezoko	258	4	,	,	,
cord-316534-ep7ezoko	258	5	strong	strong	JJ
cord-316534-ep7ezoko	258	6	immunity	immunity	NN
cord-316534-ep7ezoko	258	7	is	be	VBZ
cord-316534-ep7ezoko	258	8	required	require	VBN
cord-316534-ep7ezoko	258	9	to	to	TO
cord-316534-ep7ezoko	258	10	provide	provide	VB
cord-316534-ep7ezoko	258	11	a	a	DT
cord-316534-ep7ezoko	258	12	protective	protective	JJ
cord-316534-ep7ezoko	258	13	immunological	immunological	JJ
cord-316534-ep7ezoko	258	14	barrier	barrier	NN
cord-316534-ep7ezoko	258	15	at	at	IN
cord-316534-ep7ezoko	258	16	the	the	DT
cord-316534-ep7ezoko	258	17	most	most	RBS
cord-316534-ep7ezoko	258	18	common	common	JJ
cord-316534-ep7ezoko	258	19	point	point	NN
cord-316534-ep7ezoko	258	20	of	of	IN
cord-316534-ep7ezoko	258	21	entry	entry	NN
cord-316534-ep7ezoko	258	22	,	,	,
cord-316534-ep7ezoko	258	23	the	the	DT
cord-316534-ep7ezoko	258	24	mucosal	mucosal	JJ
cord-316534-ep7ezoko	258	25	surfaces	surface	NNS
cord-316534-ep7ezoko	258	26	of	of	IN
cord-316534-ep7ezoko	258	27	the	the	DT
cord-316534-ep7ezoko	258	28	reproductive	reproductive	JJ
cord-316534-ep7ezoko	258	29	tract	tract	NN
cord-316534-ep7ezoko	258	30	.	.	.
cord-316534-ep7ezoko	259	1	Due	due	IN
cord-316534-ep7ezoko	259	2	to	to	IN
cord-316534-ep7ezoko	259	3	the	the	DT
cord-316534-ep7ezoko	259	4	compartmentalization	compartmentalization	NN
cord-316534-ep7ezoko	259	5	of	of	IN
cord-316534-ep7ezoko	259	6	the	the	DT
cord-316534-ep7ezoko	259	7	secretory	secretory	JJ
cord-316534-ep7ezoko	259	8	and	and	CC
cord-316534-ep7ezoko	259	9	systemic	systemic	JJ
cord-316534-ep7ezoko	259	10	immune	immune	JJ
cord-316534-ep7ezoko	259	11	systems	system	NNS
cord-316534-ep7ezoko	259	12	,	,	,
cord-316534-ep7ezoko	259	13	parenterally	parenterally	NN
cord-316534-ep7ezoko	259	14	administered	administer	VBN
cord-316534-ep7ezoko	259	15	antigens	antigen	NNS
cord-316534-ep7ezoko	259	16	do	do	VBP
cord-316534-ep7ezoko	259	17	not	not	RB
cord-316534-ep7ezoko	259	18	consistently	consistently	RB
cord-316534-ep7ezoko	259	19	stimulate	stimulate	VB
cord-316534-ep7ezoko	259	20	mucosal	mucosal	JJ
cord-316534-ep7ezoko	259	21	immunity	immunity	NN
cord-316534-ep7ezoko	259	22	.	.	.
cord-316534-ep7ezoko	260	1	152	152	CD
cord-316534-ep7ezoko	261	1	Therefore	therefore	RB
cord-316534-ep7ezoko	261	2	,	,	,
cord-316534-ep7ezoko	261	3	it	-PRON-	PRP
cord-316534-ep7ezoko	261	4	is	be	VBZ
cord-316534-ep7ezoko	261	5	important	important	JJ
cord-316534-ep7ezoko	261	6	to	to	TO
cord-316534-ep7ezoko	261	7	consider	consider	VB
cord-316534-ep7ezoko	261	8	a	a	DT
cord-316534-ep7ezoko	261	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	261	10	regime	regime	NN
cord-316534-ep7ezoko	261	11	that	that	WDT
cord-316534-ep7ezoko	261	12	induces	induce	VBZ
cord-316534-ep7ezoko	261	13	mucosal	mucosal	JJ
cord-316534-ep7ezoko	261	14	immunity	immunity	NN
cord-316534-ep7ezoko	261	15	.	.	.
cord-316534-ep7ezoko	262	1	Since	since	IN
cord-316534-ep7ezoko	262	2	CD4	CD4	NNP
cord-316534-ep7ezoko	262	3	+	+	CC
cord-316534-ep7ezoko	262	4	CCR5	CCR5	NNP
cord-316534-ep7ezoko	262	5	+	+	CC
cord-316534-ep7ezoko	262	6	memory	memory	NN
cord-316534-ep7ezoko	262	7	T	t	NN
cord-316534-ep7ezoko	262	8	cells	cell	NNS
cord-316534-ep7ezoko	262	9	are	be	VBP
cord-316534-ep7ezoko	262	10	the	the	DT
cord-316534-ep7ezoko	262	11	primary	primary	JJ
cord-316534-ep7ezoko	262	12	target	target	NN
cord-316534-ep7ezoko	262	13	of	of	IN
cord-316534-ep7ezoko	262	14	HIV	HIV	NNP
cord-316534-ep7ezoko	262	15	infection	infection	NN
cord-316534-ep7ezoko	262	16	in	in	IN
cord-316534-ep7ezoko	262	17	the	the	DT
cord-316534-ep7ezoko	262	18	gut	gut	NN
cord-316534-ep7ezoko	262	19	and	and	CC
cord-316534-ep7ezoko	262	20	mucosa	mucosa	JJ
cord-316534-ep7ezoko	262	21	and	and	CC
cord-316534-ep7ezoko	262	22	rapid	rapid	JJ
cord-316534-ep7ezoko	262	23	depletion	depletion	NN
cord-316534-ep7ezoko	262	24	of	of	IN
cord-316534-ep7ezoko	262	25	this	this	DT
cord-316534-ep7ezoko	262	26	subset	subset	NN
cord-316534-ep7ezoko	262	27	occurs	occur	VBZ
cord-316534-ep7ezoko	262	28	early	early	RB
cord-316534-ep7ezoko	262	29	after	after	IN
cord-316534-ep7ezoko	262	30	infection	infection	NN
cord-316534-ep7ezoko	262	31	,	,	,
cord-316534-ep7ezoko	262	32	208	208	CD
cord-316534-ep7ezoko	262	33	,	,	,
cord-316534-ep7ezoko	262	34	209	209	CD
cord-316534-ep7ezoko	262	35	several	several	JJ
cord-316534-ep7ezoko	262	36	studies	study	NNS
cord-316534-ep7ezoko	262	37	have	have	VBP
cord-316534-ep7ezoko	262	38	investigated	investigate	VBN
cord-316534-ep7ezoko	262	39	the	the	DT
cord-316534-ep7ezoko	262	40	role	role	NN
cord-316534-ep7ezoko	262	41	of	of	IN
cord-316534-ep7ezoko	262	42	HIV	HIV	NNP
cord-316534-ep7ezoko	262	43	mucosal	mucosal	JJ
cord-316534-ep7ezoko	262	44	immunity	immunity	NN
cord-316534-ep7ezoko	262	45	.	.	.
cord-316534-ep7ezoko	263	1	Previous	previous	JJ
cord-316534-ep7ezoko	263	2	studies	study	NNS
cord-316534-ep7ezoko	263	3	have	have	VBP
cord-316534-ep7ezoko	263	4	demonstrated	demonstrate	VBN
cord-316534-ep7ezoko	263	5	the	the	DT
cord-316534-ep7ezoko	263	6	importance	importance	NN
cord-316534-ep7ezoko	263	7	of	of	IN
cord-316534-ep7ezoko	263	8	a	a	DT
cord-316534-ep7ezoko	263	9	mucosal	mucosal	JJ
cord-316534-ep7ezoko	263	10	SIV	SIV	NNP
cord-316534-ep7ezoko	263	11	/	/	SYM
cord-316534-ep7ezoko	263	12	HIV	HIV	NNP
cord-316534-ep7ezoko	263	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	263	14	producing	produce	VBG
cord-316534-ep7ezoko	263	15	both	both	DT
cord-316534-ep7ezoko	263	16	strong	strong	JJ
cord-316534-ep7ezoko	263	17	mucosal	mucosal	JJ
cord-316534-ep7ezoko	263	18	antibody	antibody	NN
cord-316534-ep7ezoko	263	19	and	and	CC
cord-316534-ep7ezoko	263	20	CD8	CD8	NNP
cord-316534-ep7ezoko	263	21	+	+	CC
cord-316534-ep7ezoko	263	22	response	response	NN
cord-316534-ep7ezoko	263	23	capable	capable	JJ
cord-316534-ep7ezoko	263	24	of	of	IN
cord-316534-ep7ezoko	263	25	blocking	block	VBG
cord-316534-ep7ezoko	263	26	the	the	DT
cord-316534-ep7ezoko	263	27	escape	escape	NN
cord-316534-ep7ezoko	263	28	of	of	IN
cord-316534-ep7ezoko	263	29	virus	virus	NN
cord-316534-ep7ezoko	263	30	from	from	IN
cord-316534-ep7ezoko	263	31	the	the	DT
cord-316534-ep7ezoko	263	32	intestinal	intestinal	JJ
cord-316534-ep7ezoko	263	33	mucosa	mucosa	NN
cord-316534-ep7ezoko	263	34	into	into	IN
cord-316534-ep7ezoko	263	35	systemic	systemic	JJ
cord-316534-ep7ezoko	263	36	lymphoid	lymphoid	JJ
cord-316534-ep7ezoko	263	37	organs	organ	NNS
cord-316534-ep7ezoko	263	38	.	.	.
cord-316534-ep7ezoko	264	1	207	207	CD
cord-316534-ep7ezoko	264	2	,	,	,
cord-316534-ep7ezoko	264	3	[	[	-LRB-
cord-316534-ep7ezoko	264	4	210	210	CD
cord-316534-ep7ezoko	264	5	]	]	-RRB-
cord-316534-ep7ezoko	264	6	[	[	-LRB-
cord-316534-ep7ezoko	264	7	211	211	CD
cord-316534-ep7ezoko	264	8	]	]	-RRB-
cord-316534-ep7ezoko	264	9	[	[	-LRB-
cord-316534-ep7ezoko	264	10	212	212	CD
cord-316534-ep7ezoko	264	11	]	]	-RRB-
cord-316534-ep7ezoko	264	12	[	[	-LRB-
cord-316534-ep7ezoko	264	13	213	213	CD
cord-316534-ep7ezoko	264	14	]	]	-RRB-
cord-316534-ep7ezoko	264	15	[	[	-LRB-
cord-316534-ep7ezoko	264	16	214	214	CD
cord-316534-ep7ezoko	264	17	]	]	-RRB-
cord-316534-ep7ezoko	265	1	However	however	RB
cord-316534-ep7ezoko	265	2	,	,	,
cord-316534-ep7ezoko	265	3	in	in	IN
cord-316534-ep7ezoko	265	4	other	other	JJ
cord-316534-ep7ezoko	265	5	instances	instance	NNS
cord-316534-ep7ezoko	265	6	,	,	,
cord-316534-ep7ezoko	265	7	the	the	DT
cord-316534-ep7ezoko	265	8	necessity	necessity	NN
cord-316534-ep7ezoko	265	9	of	of	IN
cord-316534-ep7ezoko	265	10	exclusive	exclusive	JJ
cord-316534-ep7ezoko	265	11	mucosal	mucosal	JJ
cord-316534-ep7ezoko	265	12	HIV	HIV	NNP
cord-316534-ep7ezoko	265	13	immunity	immunity	NN
cord-316534-ep7ezoko	265	14	will	will	MD
cord-316534-ep7ezoko	265	15	be	be	VB
cord-316534-ep7ezoko	265	16	further	further	RB
cord-316534-ep7ezoko	265	17	debated	debate	VBN
cord-316534-ep7ezoko	265	18	based	base	VBN
cord-316534-ep7ezoko	265	19	on	on	IN
cord-316534-ep7ezoko	265	20	the	the	DT
cord-316534-ep7ezoko	265	21	promising	promising	JJ
cord-316534-ep7ezoko	265	22	results	result	NNS
cord-316534-ep7ezoko	265	23	found	find	VBN
cord-316534-ep7ezoko	265	24	in	in	IN
cord-316534-ep7ezoko	265	25	a	a	DT
cord-316534-ep7ezoko	265	26	heterologous	heterologous	JJ
cord-316534-ep7ezoko	265	27	prime	prime	NN
cord-316534-ep7ezoko	265	28	/	/	SYM
cord-316534-ep7ezoko	265	29	boost	boost	NN
cord-316534-ep7ezoko	265	30	regimen	regimen	NN
cord-316534-ep7ezoko	265	31	using	use	VBG
cord-316534-ep7ezoko	265	32	DNA/89.6-expressing	dna/89.6-expresse	VBG
cord-316534-ep7ezoko	265	33	SIV	SIV	NNP
cord-316534-ep7ezoko	265	34	and	and	CC
cord-316534-ep7ezoko	265	35	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	265	36	transcripts	transcript	NNS
cord-316534-ep7ezoko	265	37	215,216	215,216	CD
cord-316534-ep7ezoko	265	38	and	and	CC
cord-316534-ep7ezoko	265	39	modified	modify	VBN
cord-316534-ep7ezoko	265	40	vaccinia	vaccinia	NN
cord-316534-ep7ezoko	265	41	virus	virus	NN
cord-316534-ep7ezoko	265	42	Ankara	Ankara	NNP
cord-316534-ep7ezoko	266	1	(	(	-LRB-
cord-316534-ep7ezoko	266	2	MVA/89.6)-expressing	MVA/89.6)-expressing	NNP
cord-316534-ep7ezoko	266	3	SIV	SIV	NNP
cord-316534-ep7ezoko	266	4	and	and	CC
cord-316534-ep7ezoko	266	5	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	266	6	transcripts	transcript	NNS
cord-316534-ep7ezoko	266	7	under	under	IN
cord-316534-ep7ezoko	266	8	the	the	DT
cord-316534-ep7ezoko	266	9	control	control	NN
cord-316534-ep7ezoko	266	10	of	of	IN
cord-316534-ep7ezoko	266	11	vaccinia	vaccinia	NN
cord-316534-ep7ezoko	266	12	virus	virus	NN
cord-316534-ep7ezoko	266	13	early	early	JJ
cord-316534-ep7ezoko	266	14	/	/	SYM
cord-316534-ep7ezoko	266	15	late	late	JJ
cord-316534-ep7ezoko	266	16	promoter	promoter	NN
cord-316534-ep7ezoko	266	17	.	.	.
cord-316534-ep7ezoko	267	1	In	in	IN
cord-316534-ep7ezoko	267	2	this	this	DT
cord-316534-ep7ezoko	267	3	case	case	NN
cord-316534-ep7ezoko	267	4	,	,	,
cord-316534-ep7ezoko	267	5	either	either	CC
cord-316534-ep7ezoko	267	6	ID	ID	NNP
cord-316534-ep7ezoko	267	7	or	or	CC
cord-316534-ep7ezoko	267	8	IM	IM	NNP
cord-316534-ep7ezoko	267	9	DNA	DNA	NNP
cord-316534-ep7ezoko	267	10	/	/	SYM
cord-316534-ep7ezoko	267	11	MVA	MVA	NNP
cord-316534-ep7ezoko	267	12	vaccination	vaccination	NN
cord-316534-ep7ezoko	267	13	was	be	VBD
cord-316534-ep7ezoko	267	14	able	able	JJ
cord-316534-ep7ezoko	267	15	to	to	TO
cord-316534-ep7ezoko	267	16	provide	provide	VB
cord-316534-ep7ezoko	267	17	protection	protection	NN
cord-316534-ep7ezoko	267	18	against	against	IN
cord-316534-ep7ezoko	267	19	a	a	DT
cord-316534-ep7ezoko	267	20	intrarectal	intrarectal	JJ
cord-316534-ep7ezoko	267	21	SHIV-89.6	SHIV-89.6	NNP
cord-316534-ep7ezoko	267	22	challenge	challenge	NN
cord-316534-ep7ezoko	267	23	.	.	.
cord-316534-ep7ezoko	268	1	153	153	CD
cord-316534-ep7ezoko	269	1	Along	along	IN
cord-316534-ep7ezoko	269	2	these	these	DT
cord-316534-ep7ezoko	269	3	same	same	JJ
cord-316534-ep7ezoko	269	4	lines	line	NNS
cord-316534-ep7ezoko	269	5	,	,	,
cord-316534-ep7ezoko	269	6	recently	recently	RB
cord-316534-ep7ezoko	269	7	,	,	,
cord-316534-ep7ezoko	269	8	promising	promising	JJ
cord-316534-ep7ezoko	269	9	results	result	NNS
cord-316534-ep7ezoko	269	10	were	be	VBD
cord-316534-ep7ezoko	269	11	found	find	VBN
cord-316534-ep7ezoko	269	12	by	by	IN
cord-316534-ep7ezoko	269	13	Hessell	Hessell	NNP
cord-316534-ep7ezoko	269	14	and	and	CC
cord-316534-ep7ezoko	269	15	colleagues	colleague	NNS
cord-316534-ep7ezoko	269	16	in	in	IN
cord-316534-ep7ezoko	269	17	2010	2010	CD
cord-316534-ep7ezoko	269	18	.	.	.
cord-316534-ep7ezoko	270	1	Hessell	Hessell	NNP
cord-316534-ep7ezoko	270	2	and	and	CC
cord-316534-ep7ezoko	270	3	colleagues	colleague	NNS
cord-316534-ep7ezoko	270	4	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	270	5	that	that	IN
cord-316534-ep7ezoko	270	6	after	after	IN
cord-316534-ep7ezoko	270	7	an	an	DT
cord-316534-ep7ezoko	270	8	IV	IV	NNP
cord-316534-ep7ezoko	270	9	administration	administration	NN
cord-316534-ep7ezoko	270	10	of	of	IN
cord-316534-ep7ezoko	270	11	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	270	12	antibodies	antibody	NNS
cord-316534-ep7ezoko	270	13	2F5	2f5	CD
cord-316534-ep7ezoko	270	14	or	or	CC
cord-316534-ep7ezoko	270	15	4E10	4e10	CD
cord-316534-ep7ezoko	270	16	to	to	TO
cord-316534-ep7ezoko	270	17	six	six	CD
cord-316534-ep7ezoko	270	18	monkeys	monkey	NNS
cord-316534-ep7ezoko	270	19	followed	follow	VBN
cord-316534-ep7ezoko	270	20	by	by	IN
cord-316534-ep7ezoko	270	21	a	a	DT
cord-316534-ep7ezoko	270	22	SHIV	SHIV	NNP
cord-316534-ep7ezoko	270	23	ba	ba	NNP
cord-316534-ep7ezoko	270	24	-	-	HYPH
cord-316534-ep7ezoko	270	25	L	L	NNP
cord-316534-ep7ezoko	270	26	challenge	challenge	NN
cord-316534-ep7ezoko	270	27	,	,	,
cord-316534-ep7ezoko	270	28	five	five	CD
cord-316534-ep7ezoko	270	29	out	out	IN
cord-316534-ep7ezoko	270	30	of	of	IN
cord-316534-ep7ezoko	270	31	six	six	CD
cord-316534-ep7ezoko	270	32	monkeys	monkey	NNS
cord-316534-ep7ezoko	270	33	from	from	IN
cord-316534-ep7ezoko	270	34	either	either	DT
cord-316534-ep7ezoko	270	35	group	group	NN
cord-316534-ep7ezoko	270	36	showed	show	VBD
cord-316534-ep7ezoko	270	37	complete	complete	JJ
cord-316534-ep7ezoko	270	38	protection	protection	NN
cord-316534-ep7ezoko	270	39	and	and	CC
cord-316534-ep7ezoko	270	40	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	270	41	immunity	immunity	NN
cord-316534-ep7ezoko	270	42	.	.	.
cord-316534-ep7ezoko	271	1	A	a	DT
cord-316534-ep7ezoko	271	2	low	low	JJ
cord-316534-ep7ezoko	271	3	level	level	NN
cord-316534-ep7ezoko	271	4	of	of	IN
cord-316534-ep7ezoko	271	5	viral	viral	JJ
cord-316534-ep7ezoko	271	6	replication	replication	NN
cord-316534-ep7ezoko	271	7	could	could	MD
cord-316534-ep7ezoko	271	8	not	not	RB
cord-316534-ep7ezoko	271	9	be	be	VB
cord-316534-ep7ezoko	271	10	ruled	rule	VBN
cord-316534-ep7ezoko	271	11	out	out	RP
cord-316534-ep7ezoko	271	12	for	for	IN
cord-316534-ep7ezoko	271	13	the	the	DT
cord-316534-ep7ezoko	271	14	six	six	CD
cord-316534-ep7ezoko	271	15	monkeys	monkey	NNS
cord-316534-ep7ezoko	271	16	in	in	IN
cord-316534-ep7ezoko	271	17	either	either	DT
cord-316534-ep7ezoko	271	18	group	group	NN
cord-316534-ep7ezoko	271	19	.	.	.
cord-316534-ep7ezoko	272	1	217	217	CD
cord-316534-ep7ezoko	272	2	Replicative	Replicative	NNP
cord-316534-ep7ezoko	272	3	Ad	Ad	NNP
cord-316534-ep7ezoko	272	4	yields	yield	VBZ
cord-316534-ep7ezoko	272	5	a	a	DT
cord-316534-ep7ezoko	272	6	robust	robust	JJ
cord-316534-ep7ezoko	272	7	immune	immune	JJ
cord-316534-ep7ezoko	272	8	response	response	NN
cord-316534-ep7ezoko	272	9	at	at	IN
cord-316534-ep7ezoko	272	10	the	the	DT
cord-316534-ep7ezoko	272	11	mucosal	mucosal	JJ
cord-316534-ep7ezoko	272	12	sites	site	NNS
cord-316534-ep7ezoko	272	13	partly	partly	RB
cord-316534-ep7ezoko	272	14	because	because	IN
cord-316534-ep7ezoko	272	15	Ad	ad	NN
cord-316534-ep7ezoko	272	16	is	be	VBZ
cord-316534-ep7ezoko	272	17	known	know	VBN
cord-316534-ep7ezoko	272	18	to	to	TO
cord-316534-ep7ezoko	272	19	infect	infect	VB
cord-316534-ep7ezoko	272	20	and	and	CC
cord-316534-ep7ezoko	272	21	replicate	replicate	VB
cord-316534-ep7ezoko	272	22	in	in	IN
cord-316534-ep7ezoko	272	23	epithelial	epithelial	JJ
cord-316534-ep7ezoko	272	24	cells	cell	NNS
cord-316534-ep7ezoko	272	25	.	.	.
cord-316534-ep7ezoko	273	1	[	[	-LRB-
cord-316534-ep7ezoko	273	2	218	218	CD
cord-316534-ep7ezoko	273	3	]	]	-RRB-
cord-316534-ep7ezoko	273	4	[	[	-LRB-
cord-316534-ep7ezoko	273	5	219	219	CD
cord-316534-ep7ezoko	273	6	]	]	-RRB-
cord-316534-ep7ezoko	273	7	[	[	-LRB-
cord-316534-ep7ezoko	273	8	220	220	CD
cord-316534-ep7ezoko	273	9	]	]	-RRB-
cord-316534-ep7ezoko	273	10	[	[	-LRB-
cord-316534-ep7ezoko	273	11	221	221	CD
cord-316534-ep7ezoko	273	12	]	]	-RRB-
cord-316534-ep7ezoko	274	1	Various	various	JJ
cord-316534-ep7ezoko	274	2	strategies	strategy	NNS
cord-316534-ep7ezoko	274	3	have	have	VBP
cord-316534-ep7ezoko	274	4	been	be	VBN
cord-316534-ep7ezoko	274	5	used	use	VBN
cord-316534-ep7ezoko	274	6	to	to	TO
cord-316534-ep7ezoko	274	7	achieve	achieve	VB
cord-316534-ep7ezoko	274	8	mucosal	mucosal	JJ
cord-316534-ep7ezoko	274	9	immunity	immunity	NN
cord-316534-ep7ezoko	274	10	via	via	IN
cord-316534-ep7ezoko	274	11	the	the	DT
cord-316534-ep7ezoko	274	12	oral	oral	JJ
cord-316534-ep7ezoko	274	13	route	route	NN
cord-316534-ep7ezoko	274	14	.	.	.
cord-316534-ep7ezoko	275	1	One	one	CD
cord-316534-ep7ezoko	275	2	such	such	JJ
cord-316534-ep7ezoko	275	3	strategy	strategy	NN
cord-316534-ep7ezoko	275	4	embodies	embody	VBZ
cord-316534-ep7ezoko	275	5	the	the	DT
cord-316534-ep7ezoko	275	6	development	development	NN
cord-316534-ep7ezoko	275	7	of	of	IN
cord-316534-ep7ezoko	275	8	replication	replication	NN
cord-316534-ep7ezoko	275	9	-	-	HYPH
cord-316534-ep7ezoko	275	10	defective	defective	JJ
cord-316534-ep7ezoko	275	11	recombinant	recombinant	JJ
cord-316534-ep7ezoko	275	12	Ad	ad	NN
cord-316534-ep7ezoko	275	13	serotype	serotype	NN
cord-316534-ep7ezoko	275	14	41	41	CD
cord-316534-ep7ezoko	275	15	(	(	-LRB-
cord-316534-ep7ezoko	275	16	Ad41	Ad41	NNP
cord-316534-ep7ezoko	275	17	)	)	-RRB-
cord-316534-ep7ezoko	275	18	vector	vector	NN
cord-316534-ep7ezoko	275	19	.	.	.
cord-316534-ep7ezoko	276	1	222	222	CD
cord-316534-ep7ezoko	276	2	Serotype	Serotype	NNP
cord-316534-ep7ezoko	276	3	41	41	CD
cord-316534-ep7ezoko	276	4	vectors	vector	NNS
cord-316534-ep7ezoko	276	5	are	be	VBP
cord-316534-ep7ezoko	276	6	being	be	VBG
cord-316534-ep7ezoko	276	7	currently	currently	RB
cord-316534-ep7ezoko	276	8	used	use	VBN
cord-316534-ep7ezoko	276	9	because	because	IN
cord-316534-ep7ezoko	276	10	Ad41	Ad41	NNP
cord-316534-ep7ezoko	276	11	has	have	VBZ
cord-316534-ep7ezoko	276	12	a	a	DT
cord-316534-ep7ezoko	276	13	natural	natural	JJ
cord-316534-ep7ezoko	276	14	tropism	tropism	NN
cord-316534-ep7ezoko	276	15	for	for	IN
cord-316534-ep7ezoko	276	16	the	the	DT
cord-316534-ep7ezoko	276	17	gut	gut	NN
cord-316534-ep7ezoko	276	18	and	and	CC
cord-316534-ep7ezoko	276	19	causes	cause	VBZ
cord-316534-ep7ezoko	276	20	no	no	DT
cord-316534-ep7ezoko	276	21	pathological	pathological	JJ
cord-316534-ep7ezoko	276	22	disease	disease	NN
cord-316534-ep7ezoko	276	23	outside	outside	IN
cord-316534-ep7ezoko	276	24	of	of	IN
cord-316534-ep7ezoko	276	25	the	the	DT
cord-316534-ep7ezoko	276	26	gastrointestinal	gastrointestinal	JJ
cord-316534-ep7ezoko	276	27	tract	tract	NN
cord-316534-ep7ezoko	276	28	.	.	.
cord-316534-ep7ezoko	277	1	223	223	CD
cord-316534-ep7ezoko	277	2	Ad41	Ad41	NNP
cord-316534-ep7ezoko	277	3	vectors	vector	NNS
cord-316534-ep7ezoko	277	4	are	be	VBP
cord-316534-ep7ezoko	277	5	likely	likely	JJ
cord-316534-ep7ezoko	277	6	to	to	TO
cord-316534-ep7ezoko	277	7	have	have	VB
cord-316534-ep7ezoko	277	8	a	a	DT
cord-316534-ep7ezoko	277	9	preferential	preferential	JJ
cord-316534-ep7ezoko	277	10	tropism	tropism	NN
cord-316534-ep7ezoko	277	11	for	for	IN
cord-316534-ep7ezoko	277	12	the	the	DT
cord-316534-ep7ezoko	277	13	gut	gut	NN
cord-316534-ep7ezoko	277	14	because	because	IN
cord-316534-ep7ezoko	277	15	Ad41	Ad41	NNP
cord-316534-ep7ezoko	277	16	appears	appear	VBZ
cord-316534-ep7ezoko	277	17	to	to	TO
cord-316534-ep7ezoko	277	18	have	have	VB
cord-316534-ep7ezoko	277	19	a	a	DT
cord-316534-ep7ezoko	277	20	resistance	resistance	NN
cord-316534-ep7ezoko	277	21	to	to	IN
cord-316534-ep7ezoko	277	22	acidic	acidic	JJ
cord-316534-ep7ezoko	277	23	pH	pH	NNP
cord-316534-ep7ezoko	277	24	224	224	CD
cord-316534-ep7ezoko	277	25	and	and	CC
cord-316534-ep7ezoko	277	26	the	the	DT
cord-316534-ep7ezoko	277	27	capsid	capsid	JJ
cord-316534-ep7ezoko	277	28	configuration	configuration	NN
cord-316534-ep7ezoko	277	29	of	of	IN
cord-316534-ep7ezoko	277	30	long	long	JJ
cord-316534-ep7ezoko	277	31	and	and	CC
cord-316534-ep7ezoko	277	32	short	short	JJ
cord-316534-ep7ezoko	277	33	fibers	fiber	NNS
cord-316534-ep7ezoko	277	34	allows	allow	VBZ
cord-316534-ep7ezoko	277	35	the	the	DT
cord-316534-ep7ezoko	277	36	Ad41	Ad41	NNP
cord-316534-ep7ezoko	277	37	virus	virus	NN
cord-316534-ep7ezoko	277	38	to	to	TO
cord-316534-ep7ezoko	277	39	preferentially	preferentially	RB
cord-316534-ep7ezoko	277	40	infect	infect	VB
cord-316534-ep7ezoko	277	41	the	the	DT
cord-316534-ep7ezoko	277	42	gut	gut	NN
cord-316534-ep7ezoko	277	43	.	.	.
cord-316534-ep7ezoko	278	1	177	177	CD
cord-316534-ep7ezoko	278	2	,	,	,
cord-316534-ep7ezoko	278	3	225	225	CD
cord-316534-ep7ezoko	278	4	Live	live	JJ
cord-316534-ep7ezoko	278	5	recombinant	recombinant	JJ
cord-316534-ep7ezoko	278	6	vectors	vector	NNS
cord-316534-ep7ezoko	278	7	for	for	IN
cord-316534-ep7ezoko	278	8	vaccine	vaccine	NN
cord-316534-ep7ezoko	278	9	development	development	NN
cord-316534-ep7ezoko	278	10	engineered	engineer	VBN
cord-316534-ep7ezoko	278	11	to	to	TO
cord-316534-ep7ezoko	278	12	express	express	VB
cord-316534-ep7ezoko	278	13	/	/	SYM
cord-316534-ep7ezoko	278	14	present	present	JJ
cord-316534-ep7ezoko	278	15	Hiv-1	Hiv-1	NNP
cord-316534-ep7ezoko	278	16	antigens	antigen	NNS
cord-316534-ep7ezoko	279	1	As	as	IN
cord-316534-ep7ezoko	279	2	previously	previously	RB
cord-316534-ep7ezoko	279	3	mentioned	mention	VBN
cord-316534-ep7ezoko	279	4	,	,	,
cord-316534-ep7ezoko	279	5	viral	viral	JJ
cord-316534-ep7ezoko	279	6	vectors	vector	NNS
cord-316534-ep7ezoko	279	7	are	be	VBP
cord-316534-ep7ezoko	279	8	potent	potent	JJ
cord-316534-ep7ezoko	279	9	inducers	inducer	NNS
cord-316534-ep7ezoko	279	10	of	of	IN
cord-316534-ep7ezoko	279	11	cellular	cellular	JJ
cord-316534-ep7ezoko	279	12	and	and	CC
cord-316534-ep7ezoko	279	13	humoral	humoral	JJ
cord-316534-ep7ezoko	279	14	responses	response	NNS
cord-316534-ep7ezoko	279	15	.	.	.
cord-316534-ep7ezoko	280	1	Of	of	IN
cord-316534-ep7ezoko	280	2	note	note	VB
cord-316534-ep7ezoko	280	3	,	,	,
cord-316534-ep7ezoko	280	4	viral	viral	JJ
cord-316534-ep7ezoko	280	5	vectors	vector	NNS
cord-316534-ep7ezoko	280	6	have	have	VBP
cord-316534-ep7ezoko	280	7	been	be	VBN
cord-316534-ep7ezoko	280	8	practically	practically	RB
cord-316534-ep7ezoko	280	9	used	use	VBN
cord-316534-ep7ezoko	280	10	for	for	IN
cord-316534-ep7ezoko	280	11	human	human	JJ
cord-316534-ep7ezoko	280	12	applications	application	NNS
cord-316534-ep7ezoko	280	13	and	and	CC
cord-316534-ep7ezoko	280	14	have	have	VBP
cord-316534-ep7ezoko	280	15	progressed	progress	VBN
cord-316534-ep7ezoko	280	16	treating	treat	VBG
cord-316534-ep7ezoko	280	17	a	a	DT
cord-316534-ep7ezoko	280	18	variety	variety	NN
cord-316534-ep7ezoko	280	19	of	of	IN
cord-316534-ep7ezoko	280	20	disease	disease	NN
cord-316534-ep7ezoko	280	21	contexts	context	NNS
cord-316534-ep7ezoko	280	22	such	such	JJ
cord-316534-ep7ezoko	280	23	as	as	IN
cord-316534-ep7ezoko	280	24	cancer	cancer	NN
cord-316534-ep7ezoko	280	25	and	and	CC
cord-316534-ep7ezoko	280	26	infectious	infectious	JJ
cord-316534-ep7ezoko	280	27	diseases	disease	NNS
cord-316534-ep7ezoko	280	28	.	.	.
cord-316534-ep7ezoko	281	1	[	[	-LRB-
cord-316534-ep7ezoko	281	2	226	226	CD
cord-316534-ep7ezoko	281	3	]	]	-RRB-
cord-316534-ep7ezoko	281	4	[	[	-LRB-
cord-316534-ep7ezoko	281	5	227	227	CD
cord-316534-ep7ezoko	281	6	]	]	-RRB-
cord-316534-ep7ezoko	282	1	[	[	-LRB-
cord-316534-ep7ezoko	282	2	228	228	CD
cord-316534-ep7ezoko	282	3	]	]	-RRB-
cord-316534-ep7ezoko	283	1	[	[	-LRB-
cord-316534-ep7ezoko	283	2	229	229	CD
cord-316534-ep7ezoko	283	3	]	]	-RRB-
cord-316534-ep7ezoko	283	4	Traditional	traditional	JJ
cord-316534-ep7ezoko	283	5	viral	viral	JJ
cord-316534-ep7ezoko	283	6	vector	vector	NN
cord-316534-ep7ezoko	283	7	immunization	immunization	NN
cord-316534-ep7ezoko	283	8	embodies	embody	VBZ
cord-316534-ep7ezoko	283	9	the	the	DT
cord-316534-ep7ezoko	283	10	concept	concept	NN
cord-316534-ep7ezoko	283	11	that	that	IN
cord-316534-ep7ezoko	283	12	the	the	DT
cord-316534-ep7ezoko	283	13	vector	vector	NN
cord-316534-ep7ezoko	283	14	uses	use	VBZ
cord-316534-ep7ezoko	283	15	the	the	DT
cord-316534-ep7ezoko	283	16	host	host	NN
cord-316534-ep7ezoko	283	17	cell	cell	NN
cord-316534-ep7ezoko	283	18	machinery	machinery	NN
cord-316534-ep7ezoko	283	19	to	to	TO
cord-316534-ep7ezoko	283	20	express	express	VB
cord-316534-ep7ezoko	283	21	antigens	antigen	NNS
cord-316534-ep7ezoko	283	22	,	,	,
cord-316534-ep7ezoko	283	23	which	which	WDT
cord-316534-ep7ezoko	283	24	are	be	VBP
cord-316534-ep7ezoko	283	25	encoded	encode	VBN
cord-316534-ep7ezoko	283	26	as	as	IN
cord-316534-ep7ezoko	283	27	transgenes	transgene	NNS
cord-316534-ep7ezoko	283	28	within	within	IN
cord-316534-ep7ezoko	283	29	the	the	DT
cord-316534-ep7ezoko	283	30	viral	viral	JJ
cord-316534-ep7ezoko	283	31	vector	vector	NN
cord-316534-ep7ezoko	283	32	.	.	.
cord-316534-ep7ezoko	284	1	Cellular	cellular	JJ
cord-316534-ep7ezoko	284	2	and	and	CC
cord-316534-ep7ezoko	284	3	humoral	humoral	JJ
cord-316534-ep7ezoko	284	4	immune	immune	JJ
cord-316534-ep7ezoko	284	5	responses	response	NNS
cord-316534-ep7ezoko	284	6	are	be	VBP
cord-316534-ep7ezoko	284	7	generated	generate	VBN
cord-316534-ep7ezoko	284	8	against	against	IN
cord-316534-ep7ezoko	284	9	these	these	DT
cord-316534-ep7ezoko	284	10	antigens	antigen	NNS
cord-316534-ep7ezoko	284	11	.	.	.
cord-316534-ep7ezoko	285	1	Over	over	IN
cord-316534-ep7ezoko	285	2	the	the	DT
cord-316534-ep7ezoko	285	3	last	last	JJ
cord-316534-ep7ezoko	285	4	20	20	CD
cord-316534-ep7ezoko	285	5	years	year	NNS
cord-316534-ep7ezoko	285	6	,	,	,
cord-316534-ep7ezoko	285	7	several	several	JJ
cord-316534-ep7ezoko	285	8	viral	viral	JJ
cord-316534-ep7ezoko	285	9	vectors	vector	NNS
cord-316534-ep7ezoko	285	10	have	have	VBP
cord-316534-ep7ezoko	285	11	been	be	VBN
cord-316534-ep7ezoko	285	12	derived	derive	VBN
cord-316534-ep7ezoko	285	13	to	to	TO
cord-316534-ep7ezoko	285	14	express	express	VB
cord-316534-ep7ezoko	285	15	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	285	16	antigens	antigen	NNS
cord-316534-ep7ezoko	285	17	for	for	IN
cord-316534-ep7ezoko	285	18	vaccine	vaccine	NN
cord-316534-ep7ezoko	285	19	purposes	purpose	NNS
cord-316534-ep7ezoko	285	20	.	.	.
cord-316534-ep7ezoko	286	1	Some	some	DT
cord-316534-ep7ezoko	286	2	researchers	researcher	NNS
cord-316534-ep7ezoko	286	3	have	have	VBP
cord-316534-ep7ezoko	286	4	taken	take	VBN
cord-316534-ep7ezoko	286	5	an	an	DT
cord-316534-ep7ezoko	286	6	alternative	alternative	JJ
cord-316534-ep7ezoko	286	7	approach	approach	NN
cord-316534-ep7ezoko	286	8	to	to	IN
cord-316534-ep7ezoko	286	9	conventional	conventional	JJ
cord-316534-ep7ezoko	286	10	transgene	transgene	NN
cord-316534-ep7ezoko	286	11	expression	expression	NN
cord-316534-ep7ezoko	286	12	of	of	IN
cord-316534-ep7ezoko	286	13	antigens	antigen	NNS
cord-316534-ep7ezoko	286	14	by	by	IN
cord-316534-ep7ezoko	286	15	means	mean	NNS
cord-316534-ep7ezoko	286	16	of	of	IN
cord-316534-ep7ezoko	286	17	viral	viral	JJ
cord-316534-ep7ezoko	286	18	vectors	vector	NNS
cord-316534-ep7ezoko	286	19	;	;	:
cord-316534-ep7ezoko	286	20	this	this	DT
cord-316534-ep7ezoko	286	21	alternative	alternative	JJ
cord-316534-ep7ezoko	286	22	approach	approach	NN
cord-316534-ep7ezoko	286	23	embodies	embody	VBZ
cord-316534-ep7ezoko	286	24	the	the	DT
cord-316534-ep7ezoko	286	25	capsid	capsid	JJ
cord-316534-ep7ezoko	286	26	incorporation	incorporation	NN
cord-316534-ep7ezoko	286	27	of	of	IN
cord-316534-ep7ezoko	286	28	antigens	antigen	NNS
cord-316534-ep7ezoko	286	29	.	.	.
cord-316534-ep7ezoko	287	1	This	this	DT
cord-316534-ep7ezoko	287	2	innovative	innovative	JJ
cord-316534-ep7ezoko	287	3	paradigm	paradigm	NN
cord-316534-ep7ezoko	287	4	is	be	VBZ
cord-316534-ep7ezoko	287	5	based	base	VBN
cord-316534-ep7ezoko	287	6	upon	upon	IN
cord-316534-ep7ezoko	287	7	the	the	DT
cord-316534-ep7ezoko	287	8	vector	vector	NN
cord-316534-ep7ezoko	287	9	presenting	present	VBG
cord-316534-ep7ezoko	287	10	the	the	DT
cord-316534-ep7ezoko	287	11	antigen	antigen	NN
cord-316534-ep7ezoko	287	12	as	as	IN
cord-316534-ep7ezoko	287	13	a	a	DT
cord-316534-ep7ezoko	287	14	component	component	NN
cord-316534-ep7ezoko	287	15	of	of	IN
cord-316534-ep7ezoko	287	16	the	the	DT
cord-316534-ep7ezoko	287	17	capsid	capsid	NN
cord-316534-ep7ezoko	287	18	rather	rather	RB
cord-316534-ep7ezoko	287	19	than	than	IN
cord-316534-ep7ezoko	287	20	an	an	DT
cord-316534-ep7ezoko	287	21	encoded	encode	VBN
cord-316534-ep7ezoko	287	22	transgene	transgene	NN
cord-316534-ep7ezoko	287	23	.	.	.
cord-316534-ep7ezoko	288	1	Incorporation	incorporation	NN
cord-316534-ep7ezoko	288	2	of	of	IN
cord-316534-ep7ezoko	288	3	immunogenic	immunogenic	JJ
cord-316534-ep7ezoko	288	4	peptides	peptide	NNS
cord-316534-ep7ezoko	288	5	into	into	IN
cord-316534-ep7ezoko	288	6	the	the	DT
cord-316534-ep7ezoko	288	7	vector	vector	NN
cord-316534-ep7ezoko	288	8	capsid	capsid	NN
cord-316534-ep7ezoko	288	9	offers	offer	VBZ
cord-316534-ep7ezoko	288	10	potential	potential	JJ
cord-316534-ep7ezoko	288	11	advantages	advantage	NNS
cord-316534-ep7ezoko	288	12	.	.	.
cord-316534-ep7ezoko	289	1	In	in	IN
cord-316534-ep7ezoko	289	2	this	this	DT
cord-316534-ep7ezoko	289	3	regard	regard	NN
cord-316534-ep7ezoko	289	4	,	,	,
cord-316534-ep7ezoko	289	5	the	the	DT
cord-316534-ep7ezoko	289	6	processing	processing	NN
cord-316534-ep7ezoko	289	7	of	of	IN
cord-316534-ep7ezoko	289	8	the	the	DT
cord-316534-ep7ezoko	289	9	capsidincorporated	capsidincorporated	JJ
cord-316534-ep7ezoko	289	10	antigen	antigen	NN
cord-316534-ep7ezoko	289	11	via	via	IN
cord-316534-ep7ezoko	289	12	the	the	DT
cord-316534-ep7ezoko	289	13	exogenous	exogenous	JJ
cord-316534-ep7ezoko	289	14	pathway	pathway	NN
cord-316534-ep7ezoko	289	15	should	should	MD
cord-316534-ep7ezoko	289	16	result	result	VB
cord-316534-ep7ezoko	289	17	in	in	IN
cord-316534-ep7ezoko	289	18	a	a	DT
cord-316534-ep7ezoko	289	19	strong	strong	JJ
cord-316534-ep7ezoko	289	20	humoral	humoral	JJ
cord-316534-ep7ezoko	289	21	response	response	NN
cord-316534-ep7ezoko	289	22	similar	similar	JJ
cord-316534-ep7ezoko	289	23	to	to	IN
cord-316534-ep7ezoko	289	24	the	the	DT
cord-316534-ep7ezoko	289	25	response	response	NN
cord-316534-ep7ezoko	289	26	provoked	provoke	VBN
cord-316534-ep7ezoko	289	27	by	by	IN
cord-316534-ep7ezoko	289	28	native	native	JJ
cord-316534-ep7ezoko	289	29	Ad	ad	NN
cord-316534-ep7ezoko	289	30	capsid	capsid	NN
cord-316534-ep7ezoko	289	31	proteins	protein	NNS
cord-316534-ep7ezoko	289	32	.	.	.
cord-316534-ep7ezoko	290	1	In	in	IN
cord-316534-ep7ezoko	290	2	this	this	DT
cord-316534-ep7ezoko	290	3	arrangement	arrangement	NN
cord-316534-ep7ezoko	290	4	,	,	,
cord-316534-ep7ezoko	290	5	potentially	potentially	RB
cord-316534-ep7ezoko	290	6	,	,	,
cord-316534-ep7ezoko	290	7	HIV	HIV	NNP
cord-316534-ep7ezoko	290	8	peptide	peptide	NN
cord-316534-ep7ezoko	290	9	antigens	antigen	NNS
cord-316534-ep7ezoko	290	10	accrue	accrue	VBP
cord-316534-ep7ezoko	290	11	the	the	DT
cord-316534-ep7ezoko	290	12	potent	potent	JJ
cord-316534-ep7ezoko	290	13	immunostimulatory	immunostimulatory	JJ
cord-316534-ep7ezoko	290	14	effects	effect	NNS
cord-316534-ep7ezoko	290	15	of	of	IN
cord-316534-ep7ezoko	290	16	the	the	DT
cord-316534-ep7ezoko	290	17	native	native	JJ
cord-316534-ep7ezoko	290	18	Ad	ad	NN
cord-316534-ep7ezoko	290	19	vector	vector	NN
cord-316534-ep7ezoko	290	20	capsid	capsid	NN
cord-316534-ep7ezoko	290	21	proteins	protein	NNS
cord-316534-ep7ezoko	290	22	,	,	,
cord-316534-ep7ezoko	290	23	which	which	WDT
cord-316534-ep7ezoko	290	24	effectively	effectively	RB
cord-316534-ep7ezoko	290	25	perform	perform	VBP
cord-316534-ep7ezoko	290	26	an	an	DT
cord-316534-ep7ezoko	290	27	adjuvant	adjuvant	NN
cord-316534-ep7ezoko	290	28	function	function	NN
cord-316534-ep7ezoko	290	29	.	.	.
cord-316534-ep7ezoko	291	1	On	on	IN
cord-316534-ep7ezoko	291	2	this	this	DT
cord-316534-ep7ezoko	291	3	basis	basis	NN
cord-316534-ep7ezoko	291	4	,	,	,
cord-316534-ep7ezoko	291	5	the	the	DT
cord-316534-ep7ezoko	291	6	immune	immune	JJ
cord-316534-ep7ezoko	291	7	response	response	NN
cord-316534-ep7ezoko	291	8	directed	direct	VBN
cord-316534-ep7ezoko	291	9	against	against	IN
cord-316534-ep7ezoko	291	10	vector	vector	NN
cord-316534-ep7ezoko	291	11	capsid	capsid	NN
cord-316534-ep7ezoko	291	12	proteins	protein	VBZ
cord-316534-ep7ezoko	291	13	with	with	IN
cord-316534-ep7ezoko	291	14	repetitive	repetitive	JJ
cord-316534-ep7ezoko	291	15	vector	vector	NN
cord-316534-ep7ezoko	291	16	administration	administration	NN
cord-316534-ep7ezoko	291	17	should	should	MD
cord-316534-ep7ezoko	291	18	achieve	achieve	VB
cord-316534-ep7ezoko	291	19	a	a	DT
cord-316534-ep7ezoko	291	20	booster	booster	NN
cord-316534-ep7ezoko	291	21	effect	effect	NN
cord-316534-ep7ezoko	291	22	against	against	IN
cord-316534-ep7ezoko	291	23	the	the	DT
cord-316534-ep7ezoko	291	24	incorporated	incorporated	JJ
cord-316534-ep7ezoko	291	25	antigen	antigen	NN
cord-316534-ep7ezoko	291	26	.	.	.
cord-316534-ep7ezoko	292	1	230	230	CD
cord-316534-ep7ezoko	292	2	Most	most	RBS
cord-316534-ep7ezoko	292	3	importantly	importantly	RB
cord-316534-ep7ezoko	292	4	,	,	,
cord-316534-ep7ezoko	292	5	as	as	IN
cord-316534-ep7ezoko	292	6	it	-PRON-	PRP
cord-316534-ep7ezoko	292	7	relates	relate	VBZ
cord-316534-ep7ezoko	292	8	to	to	IN
cord-316534-ep7ezoko	292	9	HIV	HIV	NNP
cord-316534-ep7ezoko	292	10	infection	infection	NN
cord-316534-ep7ezoko	292	11	,	,	,
cord-316534-ep7ezoko	292	12	this	this	DT
cord-316534-ep7ezoko	292	13	strategy	strategy	NN
cord-316534-ep7ezoko	292	14	yields	yield	VBZ
cord-316534-ep7ezoko	292	15	the	the	DT
cord-316534-ep7ezoko	292	16	potential	potential	NN
cord-316534-ep7ezoko	292	17	of	of	IN
cord-316534-ep7ezoko	292	18	generating	generate	VBG
cord-316534-ep7ezoko	292	19	antibodies	antibody	NNS
cord-316534-ep7ezoko	292	20	to	to	IN
cord-316534-ep7ezoko	292	21	HIV	HIV	NNP
cord-316534-ep7ezoko	292	22	proteins	protein	NNS
cord-316534-ep7ezoko	292	23	.	.	.
cord-316534-ep7ezoko	293	1	Recent	recent	JJ
cord-316534-ep7ezoko	293	2	crystallographic	crystallographic	JJ
cord-316534-ep7ezoko	293	3	,	,	,
cord-316534-ep7ezoko	293	4	cryo	cryo	NN
cord-316534-ep7ezoko	293	5	-	-	HYPH
cord-316534-ep7ezoko	293	6	electron	electron	NN
cord-316534-ep7ezoko	293	7	tomography	tomography	NN
cord-316534-ep7ezoko	293	8	,	,	,
cord-316534-ep7ezoko	293	9	and	and	CC
cord-316534-ep7ezoko	293	10	molecular	molecular	JJ
cord-316534-ep7ezoko	293	11	modeling	modeling	NN
cord-316534-ep7ezoko	293	12	studies	study	NNS
cord-316534-ep7ezoko	293	13	have	have	VBP
cord-316534-ep7ezoko	293	14	provided	provide	VBN
cord-316534-ep7ezoko	293	15	valuable	valuable	JJ
cord-316534-ep7ezoko	293	16	insight	insight	NN
cord-316534-ep7ezoko	293	17	to	to	IN
cord-316534-ep7ezoko	293	18	molecular	molecular	JJ
cord-316534-ep7ezoko	293	19	surfaces	surface	NNS
cord-316534-ep7ezoko	293	20	recognized	recognize	VBN
cord-316534-ep7ezoko	293	21	by	by	IN
cord-316534-ep7ezoko	293	22	antibodies	antibody	NNS
cord-316534-ep7ezoko	293	23	as	as	RB
cord-316534-ep7ezoko	293	24	well	well	RB
cord-316534-ep7ezoko	293	25	as	as	IN
cord-316534-ep7ezoko	293	26	assisted	assist	VBN
cord-316534-ep7ezoko	293	27	in	in	IN
cord-316534-ep7ezoko	293	28	rationale	rationale	NN
cord-316534-ep7ezoko	293	29	vaccine	vaccine	NN
cord-316534-ep7ezoko	293	30	design	design	NN
cord-316534-ep7ezoko	293	31	of	of	IN
cord-316534-ep7ezoko	293	32	immunogens	immunogens	NNP
cord-316534-ep7ezoko	293	33	.	.	.
cord-316534-ep7ezoko	294	1	[	[	-LRB-
cord-316534-ep7ezoko	294	2	231	231	CD
cord-316534-ep7ezoko	294	3	]	]	-RRB-
cord-316534-ep7ezoko	294	4	[	[	-LRB-
cord-316534-ep7ezoko	294	5	232	232	CD
cord-316534-ep7ezoko	294	6	]	]	-RRB-
cord-316534-ep7ezoko	294	7	[	[	-LRB-
cord-316534-ep7ezoko	294	8	233	233	CD
cord-316534-ep7ezoko	294	9	]	]	-RRB-
cord-316534-ep7ezoko	294	10	[	[	-LRB-
cord-316534-ep7ezoko	294	11	234	234	CD
cord-316534-ep7ezoko	294	12	]	]	-RRB-
cord-316534-ep7ezoko	295	1	[	[	-LRB-
cord-316534-ep7ezoko	295	2	235	235	CD
cord-316534-ep7ezoko	295	3	]	]	-RRB-
cord-316534-ep7ezoko	296	1	These	these	DT
cord-316534-ep7ezoko	296	2	structural	structural	JJ
cord-316534-ep7ezoko	296	3	technologies	technology	NNS
cord-316534-ep7ezoko	296	4	can	can	MD
cord-316534-ep7ezoko	296	5	also	also	RB
cord-316534-ep7ezoko	296	6	potentially	potentially	RB
cord-316534-ep7ezoko	296	7	improve	improve	VB
cord-316534-ep7ezoko	296	8	the	the	DT
cord-316534-ep7ezoko	296	9	abilities	ability	NNS
cord-316534-ep7ezoko	296	10	of	of	IN
cord-316534-ep7ezoko	296	11	scientists	scientist	NNS
cord-316534-ep7ezoko	296	12	to	to	TO
cord-316534-ep7ezoko	296	13	advance	advance	VB
cord-316534-ep7ezoko	296	14	the	the	DT
cord-316534-ep7ezoko	296	15	antigen	antigen	NN
cord-316534-ep7ezoko	296	16	capsidincorporation	capsidincorporation	NN
cord-316534-ep7ezoko	296	17	strategy	strategy	NN
cord-316534-ep7ezoko	296	18	.	.	.
cord-316534-ep7ezoko	297	1	If	if	IN
cord-316534-ep7ezoko	297	2	the	the	DT
cord-316534-ep7ezoko	297	3	antigen	antigen	NN
cord-316534-ep7ezoko	297	4	capsid	capsid	NN
cord-316534-ep7ezoko	297	5	incorporation	incorporation	NN
cord-316534-ep7ezoko	297	6	is	be	VBZ
cord-316534-ep7ezoko	297	7	effective	effective	JJ
cord-316534-ep7ezoko	297	8	,	,	,
cord-316534-ep7ezoko	297	9	it	-PRON-	PRP
cord-316534-ep7ezoko	297	10	can	can	MD
cord-316534-ep7ezoko	297	11	provide	provide	VB
cord-316534-ep7ezoko	297	12	a	a	DT
cord-316534-ep7ezoko	297	13	way	way	NN
cord-316534-ep7ezoko	297	14	forward	forward	RB
cord-316534-ep7ezoko	297	15	with	with	IN
cord-316534-ep7ezoko	297	16	respect	respect	NN
cord-316534-ep7ezoko	297	17	to	to	IN
cord-316534-ep7ezoko	297	18	inducing	induce	VBG
cord-316534-ep7ezoko	297	19	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	297	20	immunity	immunity	NN
cord-316534-ep7ezoko	297	21	.	.	.
cord-316534-ep7ezoko	298	1	68	68	CD
cord-316534-ep7ezoko	298	2	,	,	,
cord-316534-ep7ezoko	298	3	236	236	CD
cord-316534-ep7ezoko	299	1	,	,	,
cord-316534-ep7ezoko	299	2	237	237	CD
cord-316534-ep7ezoko	299	3	The	the	DT
cord-316534-ep7ezoko	299	4	antigen	antigen	NN
cord-316534-ep7ezoko	299	5	capsid	capsid	NN
cord-316534-ep7ezoko	299	6	-	-	HYPH
cord-316534-ep7ezoko	299	7	incorporation	incorporation	NN
cord-316534-ep7ezoko	299	8	strategy	strategy	NN
cord-316534-ep7ezoko	299	9	has	have	VBZ
cord-316534-ep7ezoko	299	10	been	be	VBN
cord-316534-ep7ezoko	299	11	used	use	VBN
cord-316534-ep7ezoko	299	12	for	for	IN
cord-316534-ep7ezoko	299	13	Ad	ad	NN
cord-316534-ep7ezoko	299	14	-	-	HYPH
cord-316534-ep7ezoko	299	15	based	base	VBN
cord-316534-ep7ezoko	299	16	vaccines	vaccine	NNS
cord-316534-ep7ezoko	299	17	in	in	IN
cord-316534-ep7ezoko	299	18	the	the	DT
cord-316534-ep7ezoko	299	19	context	context	NN
cord-316534-ep7ezoko	299	20	of	of	IN
cord-316534-ep7ezoko	299	21	many	many	JJ
cord-316534-ep7ezoko	299	22	diseases	disease	NNS
cord-316534-ep7ezoko	299	23	.	.	.
cord-316534-ep7ezoko	300	1	230	230	CD
cord-316534-ep7ezoko	300	2	,	,	,
cord-316534-ep7ezoko	300	3	[	[	-LRB-
cord-316534-ep7ezoko	300	4	238	238	CD
cord-316534-ep7ezoko	300	5	]	]	-RRB-
cord-316534-ep7ezoko	300	6	[	[	-LRB-
cord-316534-ep7ezoko	300	7	239	239	CD
cord-316534-ep7ezoko	300	8	]	]	-RRB-
cord-316534-ep7ezoko	300	9	[	[	-LRB-
cord-316534-ep7ezoko	300	10	240	240	CD
cord-316534-ep7ezoko	300	11	]	]	-RRB-
cord-316534-ep7ezoko	300	12	[	[	-LRB-
cord-316534-ep7ezoko	300	13	241	241	CD
cord-316534-ep7ezoko	300	14	]	]	-RRB-
cord-316534-ep7ezoko	300	15	[	[	-LRB-
cord-316534-ep7ezoko	300	16	242	242	CD
cord-316534-ep7ezoko	300	17	]	]	-RRB-
cord-316534-ep7ezoko	300	18	One	one	CD
cord-316534-ep7ezoko	300	19	of	of	IN
cord-316534-ep7ezoko	300	20	the	the	DT
cord-316534-ep7ezoko	300	21	first	first	JJ
cord-316534-ep7ezoko	300	22	examples	example	NNS
cord-316534-ep7ezoko	300	23	where	where	WRB
cord-316534-ep7ezoko	300	24	the	the	DT
cord-316534-ep7ezoko	300	25	antigen	antigen	NN
cord-316534-ep7ezoko	300	26	capsid	capsid	NN
cord-316534-ep7ezoko	300	27	-	-	HYPH
cord-316534-ep7ezoko	300	28	incorporation	incorporation	NN
cord-316534-ep7ezoko	300	29	strategy	strategy	NN
cord-316534-ep7ezoko	300	30	was	be	VBD
cord-316534-ep7ezoko	300	31	used	use	VBN
cord-316534-ep7ezoko	300	32	was	be	VBD
cord-316534-ep7ezoko	300	33	with	with	IN
cord-316534-ep7ezoko	300	34	research	research	NN
cord-316534-ep7ezoko	300	35	performed	perform	VBN
cord-316534-ep7ezoko	300	36	by	by	IN
cord-316534-ep7ezoko	300	37	Crompton	Crompton	NNP
cord-316534-ep7ezoko	300	38	in	in	IN
cord-316534-ep7ezoko	300	39	1994	1994	CD
cord-316534-ep7ezoko	300	40	.	.	.
cord-316534-ep7ezoko	301	1	242	242	CD
cord-316534-ep7ezoko	301	2	Crompton	Crompton	NNP
cord-316534-ep7ezoko	301	3	and	and	CC
cord-316534-ep7ezoko	301	4	colleagues	colleague	NNS
cord-316534-ep7ezoko	301	5	inserted	insert	VBD
cord-316534-ep7ezoko	301	6	an	an	DT
cord-316534-ep7ezoko	301	7	eight	eight	CD
cord-316534-ep7ezoko	301	8	-	-	HYPH
cord-316534-ep7ezoko	301	9	amino	amino	NN
cord-316534-ep7ezoko	301	10	acid	acid	NN
cord-316534-ep7ezoko	301	11	sequence	sequence	NN
cord-316534-ep7ezoko	301	12	of	of	IN
cord-316534-ep7ezoko	301	13	the	the	DT
cord-316534-ep7ezoko	301	14	VP1	VP1	NNP
cord-316534-ep7ezoko	301	15	capsid	capsid	NN
cord-316534-ep7ezoko	301	16	protein	protein	NN
cord-316534-ep7ezoko	301	17	of	of	IN
cord-316534-ep7ezoko	301	18	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	301	19	type	type	NN
cord-316534-ep7ezoko	301	20	3	3	CD
cord-316534-ep7ezoko	301	21	into	into	IN
cord-316534-ep7ezoko	301	22	two	two	CD
cord-316534-ep7ezoko	301	23	regions	region	NNS
cord-316534-ep7ezoko	301	24	of	of	IN
cord-316534-ep7ezoko	301	25	the	the	DT
cord-316534-ep7ezoko	301	26	Ad2	ad2	NN
cord-316534-ep7ezoko	301	27	serotype	serotype	NN
cord-316534-ep7ezoko	301	28	hexon	hexon	NNP
cord-316534-ep7ezoko	301	29	.	.	.
cord-316534-ep7ezoko	302	1	One	one	CD
cord-316534-ep7ezoko	302	2	of	of	IN
cord-316534-ep7ezoko	302	3	the	the	DT
cord-316534-ep7ezoko	302	4	chimeric	chimeric	JJ
cord-316534-ep7ezoko	302	5	vectors	vector	NNS
cord-316534-ep7ezoko	302	6	produced	produce	VBN
cord-316534-ep7ezoko	302	7	grew	grow	VBD
cord-316534-ep7ezoko	302	8	well	well	RB
cord-316534-ep7ezoko	302	9	in	in	IN
cord-316534-ep7ezoko	302	10	tissue	tissue	NN
cord-316534-ep7ezoko	302	11	culture	culture	NN
cord-316534-ep7ezoko	302	12	.	.	.
cord-316534-ep7ezoko	303	1	In	in	IN
cord-316534-ep7ezoko	303	2	addition	addition	NN
cord-316534-ep7ezoko	303	3	,	,	,
cord-316534-ep7ezoko	303	4	antiserum	antiserum	NN
cord-316534-ep7ezoko	303	5	raised	raise	VBD
cord-316534-ep7ezoko	303	6	against	against	IN
cord-316534-ep7ezoko	303	7	the	the	DT
cord-316534-ep7ezoko	303	8	Ad	ad	NN
cord-316534-ep7ezoko	303	9	with	with	IN
cord-316534-ep7ezoko	303	10	the	the	DT
cord-316534-ep7ezoko	303	11	polio	polio	NN
cord-316534-ep7ezoko	303	12	insert	insert	NN
cord-316534-ep7ezoko	303	13	specifically	specifically	RB
cord-316534-ep7ezoko	303	14	recognized	recognize	VBN
cord-316534-ep7ezoko	303	15	the	the	DT
cord-316534-ep7ezoko	303	16	VP1	VP1	NNP
cord-316534-ep7ezoko	303	17	capsid	capsid	NN
cord-316534-ep7ezoko	303	18	of	of	IN
cord-316534-ep7ezoko	303	19	polio	polio	NN
cord-316534-ep7ezoko	303	20	type	type	NN
cord-316534-ep7ezoko	303	21	3	3	CD
cord-316534-ep7ezoko	303	22	.	.	.
cord-316534-ep7ezoko	304	1	As	as	IN
cord-316534-ep7ezoko	304	2	it	-PRON-	PRP
cord-316534-ep7ezoko	304	3	relates	relate	VBZ
cord-316534-ep7ezoko	304	4	to	to	IN
cord-316534-ep7ezoko	304	5	Ad5	Ad5	NNP
cord-316534-ep7ezoko	304	6	serotype	serotype	NN
cord-316534-ep7ezoko	304	7	,	,	,
cord-316534-ep7ezoko	304	8	Wu	Wu	NNP
cord-316534-ep7ezoko	304	9	and	and	CC
cord-316534-ep7ezoko	304	10	group	group	NN
cord-316534-ep7ezoko	304	11	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	304	12	that	that	IN
cord-316534-ep7ezoko	304	13	His	-PRON-	PRP$
cord-316534-ep7ezoko	304	14	6	6	CD
cord-316534-ep7ezoko	304	15	epitopes	epitope	NNS
cord-316534-ep7ezoko	304	16	could	could	MD
cord-316534-ep7ezoko	304	17	be	be	VB
cord-316534-ep7ezoko	304	18	incorporated	incorporate	VBN
cord-316534-ep7ezoko	304	19	into	into	IN
cord-316534-ep7ezoko	304	20	Ad	ad	NN
cord-316534-ep7ezoko	304	21	hexon	hexon	NN
cord-316534-ep7ezoko	304	22	hypervariable	hypervariable	JJ
cord-316534-ep7ezoko	304	23	regions	region	NNS
cord-316534-ep7ezoko	304	24	(	(	-LRB-
cord-316534-ep7ezoko	304	25	HVRs	HVRs	NNP
cord-316534-ep7ezoko	304	26	)	)	-RRB-
cord-316534-ep7ezoko	305	1	1	1	LS
cord-316534-ep7ezoko	305	2	-	-	SYM
cord-316534-ep7ezoko	305	3	7	7	CD
cord-316534-ep7ezoko	305	4	(	(	-LRB-
cord-316534-ep7ezoko	305	5	now	now	RB
cord-316534-ep7ezoko	305	6	reclassified	reclassify	VBN
cord-316534-ep7ezoko	305	7	as	as	IN
cord-316534-ep7ezoko	305	8	1	1	CD
cord-316534-ep7ezoko	305	9	-	-	SYM
cord-316534-ep7ezoko	305	10	9	9	CD
cord-316534-ep7ezoko	305	11	)	)	-RRB-
cord-316534-ep7ezoko	305	12	without	without	IN
cord-316534-ep7ezoko	305	13	perturbing	perturb	VBG
cord-316534-ep7ezoko	305	14	viral	viral	JJ
cord-316534-ep7ezoko	305	15	viability	viability	NN
cord-316534-ep7ezoko	305	16	and	and	CC
cord-316534-ep7ezoko	305	17	any	any	DT
cord-316534-ep7ezoko	305	18	major	major	JJ
cord-316534-ep7ezoko	305	19	biological	biological	JJ
cord-316534-ep7ezoko	305	20	characteristics	characteristic	NNS
cord-316534-ep7ezoko	305	21	such	such	JJ
cord-316534-ep7ezoko	305	22	as	as	IN
cord-316534-ep7ezoko	305	23	replication	replication	NN
cord-316534-ep7ezoko	305	24	,	,	,
cord-316534-ep7ezoko	305	25	thermostability	thermostability	NN
cord-316534-ep7ezoko	305	26	,	,	,
cord-316534-ep7ezoko	305	27	or	or	CC
cord-316534-ep7ezoko	305	28	native	native	JJ
cord-316534-ep7ezoko	305	29	infectivity	infectivity	NN
cord-316534-ep7ezoko	305	30	.	.	.
cord-316534-ep7ezoko	306	1	This	this	DT
cord-316534-ep7ezoko	306	2	study	study	NN
cord-316534-ep7ezoko	306	3	by	by	IN
cord-316534-ep7ezoko	306	4	Wu	Wu	NNP
cord-316534-ep7ezoko	306	5	and	and	CC
cord-316534-ep7ezoko	306	6	colleagues	colleague	NNS
cord-316534-ep7ezoko	306	7	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	306	8	that	that	IN
cord-316534-ep7ezoko	306	9	His	-PRON-	PRP$
cord-316534-ep7ezoko	306	10	6	6	CD
cord-316534-ep7ezoko	306	11	appeared	appear	VBD
cord-316534-ep7ezoko	306	12	to	to	TO
cord-316534-ep7ezoko	306	13	be	be	VB
cord-316534-ep7ezoko	306	14	surface	surface	NN
cord-316534-ep7ezoko	306	15	exposed	expose	VBN
cord-316534-ep7ezoko	306	16	at	at	IN
cord-316534-ep7ezoko	306	17	these	these	DT
cord-316534-ep7ezoko	306	18	regions	region	NNS
cord-316534-ep7ezoko	306	19	.	.	.
cord-316534-ep7ezoko	307	1	243	243	CD
cord-316534-ep7ezoko	308	1	With	with	IN
cord-316534-ep7ezoko	308	2	respect	respect	NN
cord-316534-ep7ezoko	308	3	to	to	IN
cord-316534-ep7ezoko	308	4	peptide	peptide	NN
cord-316534-ep7ezoko	308	5	incorporation	incorporation	NN
cord-316534-ep7ezoko	308	6	within	within	IN
cord-316534-ep7ezoko	308	7	Ad5	Ad5	NNP
cord-316534-ep7ezoko	308	8	hexon	hexon	NNP
cord-316534-ep7ezoko	308	9	,	,	,
cord-316534-ep7ezoko	308	10	HVR2	HVR2	NNP
cord-316534-ep7ezoko	308	11	and	and	CC
cord-316534-ep7ezoko	308	12	HVR5	HVR5	NNP
cord-316534-ep7ezoko	308	13	appear	appear	VBP
cord-316534-ep7ezoko	308	14	to	to	TO
cord-316534-ep7ezoko	308	15	be	be	VB
cord-316534-ep7ezoko	308	16	the	the	DT
cord-316534-ep7ezoko	308	17	most	most	RBS
cord-316534-ep7ezoko	308	18	promising	promising	JJ
cord-316534-ep7ezoko	308	19	locales	locale	NNS
cord-316534-ep7ezoko	308	20	for	for	IN
cord-316534-ep7ezoko	308	21	peptide	peptide	NN
cord-316534-ep7ezoko	308	22	/	/	SYM
cord-316534-ep7ezoko	308	23	antigen	antigen	NN
cord-316534-ep7ezoko	308	24	incorporation	incorporation	NN
cord-316534-ep7ezoko	308	25	based	base	VBN
cord-316534-ep7ezoko	308	26	on	on	IN
cord-316534-ep7ezoko	308	27	X	x	NN
cord-316534-ep7ezoko	308	28	-	-	NN
cord-316534-ep7ezoko	308	29	ray	ray	NN
cord-316534-ep7ezoko	308	30	and	and	CC
cord-316534-ep7ezoko	308	31	peptide	peptide	NN
cord-316534-ep7ezoko	308	32	analyses	analysis	NNS
cord-316534-ep7ezoko	308	33	along	along	IN
cord-316534-ep7ezoko	308	34	with	with	IN
cord-316534-ep7ezoko	308	35	molecular	molecular	JJ
cord-316534-ep7ezoko	308	36	studies	study	NNS
cord-316534-ep7ezoko	308	37	.	.	.
cord-316534-ep7ezoko	309	1	244	244	CD
cord-316534-ep7ezoko	310	1	Our	-PRON-	PRP$
cord-316534-ep7ezoko	310	2	laboratory	laboratory	NN
cord-316534-ep7ezoko	310	3	and	and	CC
cord-316534-ep7ezoko	310	4	others	other	NNS
cord-316534-ep7ezoko	310	5	have	have	VBP
cord-316534-ep7ezoko	310	6	focused	focus	VBN
cord-316534-ep7ezoko	310	7	on	on	IN
cord-316534-ep7ezoko	310	8	incorporations	incorporation	NNS
cord-316534-ep7ezoko	310	9	at	at	IN
cord-316534-ep7ezoko	310	10	HVR5	HVR5	NNP
cord-316534-ep7ezoko	310	11	or	or	CC
cord-316534-ep7ezoko	310	12	single	single	JJ
cord-316534-ep7ezoko	310	13	-	-	HYPH
cord-316534-ep7ezoko	310	14	site	site	NN
cord-316534-ep7ezoko	310	15	incorporations	incorporation	NNS
cord-316534-ep7ezoko	310	16	(	(	-LRB-
cord-316534-ep7ezoko	310	17	such	such	JJ
cord-316534-ep7ezoko	310	18	as	as	IN
cord-316534-ep7ezoko	310	19	fiber	fiber	NN
cord-316534-ep7ezoko	310	20	and	and	CC
cord-316534-ep7ezoko	310	21	pIX	pix	NN
cord-316534-ep7ezoko	310	22	)	)	-RRB-
cord-316534-ep7ezoko	310	23	.	.	.
cord-316534-ep7ezoko	311	1	230,238	230,238	CD
cord-316534-ep7ezoko	311	2	-	-	SYM
cord-316534-ep7ezoko	311	3	241-,243,245,246	241-,243,245,246	CD
cord-316534-ep7ezoko	312	1	However	however	RB
cord-316534-ep7ezoko	312	2	,	,	,
cord-316534-ep7ezoko	312	3	we	-PRON-	PRP
cord-316534-ep7ezoko	312	4	recognized	recognize	VBD
cord-316534-ep7ezoko	312	5	that	that	IN
cord-316534-ep7ezoko	312	6	the	the	DT
cord-316534-ep7ezoko	312	7	ability	ability	NN
cord-316534-ep7ezoko	312	8	to	to	TO
cord-316534-ep7ezoko	312	9	place	place	VB
cord-316534-ep7ezoko	312	10	antigen	antigen	NN
cord-316534-ep7ezoko	312	11	within	within	IN
cord-316534-ep7ezoko	312	12	multiple	multiple	JJ
cord-316534-ep7ezoko	312	13	sites	site	NNS
cord-316534-ep7ezoko	312	14	of	of	IN
cord-316534-ep7ezoko	312	15	the	the	DT
cord-316534-ep7ezoko	312	16	Ad	ad	NN
cord-316534-ep7ezoko	312	17	capsid	capsid	NN
cord-316534-ep7ezoko	312	18	protein	protein	NN
cord-316534-ep7ezoko	312	19	would	would	MD
cord-316534-ep7ezoko	312	20	hold	hold	VB
cord-316534-ep7ezoko	312	21	important	important	JJ
cord-316534-ep7ezoko	312	22	potential	potential	NN
cord-316534-ep7ezoko	312	23	for	for	IN
cord-316534-ep7ezoko	312	24	presenting	present	VBG
cord-316534-ep7ezoko	312	25	multiple	multiple	JJ
cord-316534-ep7ezoko	312	26	epitopes/	epitopes/	CD
cord-316534-ep7ezoko	312	27	antigens	antigen	NNS
cord-316534-ep7ezoko	312	28	or	or	CC
cord-316534-ep7ezoko	312	29	several	several	JJ
cord-316534-ep7ezoko	312	30	copies	copy	NNS
cord-316534-ep7ezoko	312	31	of	of	IN
cord-316534-ep7ezoko	312	32	the	the	DT
cord-316534-ep7ezoko	312	33	same	same	JJ
cord-316534-ep7ezoko	312	34	epitope	epitope	NN
cord-316534-ep7ezoko	312	35	within	within	IN
cord-316534-ep7ezoko	312	36	a	a	DT
cord-316534-ep7ezoko	312	37	single	single	JJ
cord-316534-ep7ezoko	312	38	Ad	ad	NN
cord-316534-ep7ezoko	312	39	vector	vector	NN
cord-316534-ep7ezoko	312	40	-	-	HYPH
cord-316534-ep7ezoko	312	41	based	base	VBN
cord-316534-ep7ezoko	312	42	vaccine	vaccine	NN
cord-316534-ep7ezoko	312	43	.	.	.
cord-316534-ep7ezoko	313	1	In	in	IN
cord-316534-ep7ezoko	313	2	an	an	DT
cord-316534-ep7ezoko	313	3	effort	effort	NN
cord-316534-ep7ezoko	313	4	to	to	TO
cord-316534-ep7ezoko	313	5	create	create	VB
cord-316534-ep7ezoko	313	6	multivalent	multivalent	JJ
cord-316534-ep7ezoko	313	7	HIV	HIV	NNP
cord-316534-ep7ezoko	313	8	vaccine	vaccine	NN
cord-316534-ep7ezoko	313	9	vectors	vector	NNS
cord-316534-ep7ezoko	313	10	,	,	,
cord-316534-ep7ezoko	313	11	our	-PRON-	PRP$
cord-316534-ep7ezoko	313	12	2008	2008	CD
cord-316534-ep7ezoko	313	13	study	study	NN
cord-316534-ep7ezoko	313	14	explored	explore	VBD
cord-316534-ep7ezoko	313	15	the	the	DT
cord-316534-ep7ezoko	313	16	use	use	NN
cord-316534-ep7ezoko	313	17	of	of	IN
cord-316534-ep7ezoko	313	18	Ad5	Ad5	NNP
cord-316534-ep7ezoko	313	19	HVR2	HVR2	NNP
cord-316534-ep7ezoko	313	20	and	and	CC
cord-316534-ep7ezoko	313	21	HVR5	HVR5	NNP
cord-316534-ep7ezoko	313	22	in	in	IN
cord-316534-ep7ezoko	313	23	hopes	hope	NNS
cord-316534-ep7ezoko	313	24	of	of	IN
cord-316534-ep7ezoko	313	25	creating	create	VBG
cord-316534-ep7ezoko	313	26	vectors	vector	NNS
cord-316534-ep7ezoko	313	27	which	which	WDT
cord-316534-ep7ezoko	313	28	contained	contain	VBD
cord-316534-ep7ezoko	313	29	HIV	HIV	NNP
cord-316534-ep7ezoko	313	30	antigenic	antigenic	JJ
cord-316534-ep7ezoko	313	31	epitopes	epitope	NNS
cord-316534-ep7ezoko	313	32	at	at	IN
cord-316534-ep7ezoko	313	33	both	both	DT
cord-316534-ep7ezoko	313	34	locales	locale	NNS
cord-316534-ep7ezoko	313	35	.	.	.
cord-316534-ep7ezoko	314	1	To	to	TO
cord-316534-ep7ezoko	314	2	compare	compare	VB
cord-316534-ep7ezoko	314	3	the	the	DT
cord-316534-ep7ezoko	314	4	flexibility	flexibility	NN
cord-316534-ep7ezoko	314	5	and	and	CC
cord-316534-ep7ezoko	314	6	capacities	capacity	NNS
cord-316534-ep7ezoko	314	7	of	of	IN
cord-316534-ep7ezoko	314	8	Ad5	ad5	CD
cord-316534-ep7ezoko	314	9	HVR2	HVR2	NNP
cord-316534-ep7ezoko	314	10	and	and	CC
cord-316534-ep7ezoko	314	11	HVR5	HVR5	NNP
cord-316534-ep7ezoko	314	12	,	,	,
cord-316534-ep7ezoko	314	13	we	-PRON-	PRP
cord-316534-ep7ezoko	314	14	genetically	genetically	RB
cord-316534-ep7ezoko	314	15	incorporated	incorporate	VBD
cord-316534-ep7ezoko	314	16	identical	identical	JJ
cord-316534-ep7ezoko	314	17	epitopes	epitope	NNS
cord-316534-ep7ezoko	314	18	of	of	IN
cord-316534-ep7ezoko	314	19	incrementally	incrementally	RB
cord-316534-ep7ezoko	314	20	increasing	increase	VBG
cord-316534-ep7ezoko	314	21	size	size	NN
cord-316534-ep7ezoko	314	22	within	within	IN
cord-316534-ep7ezoko	314	23	HVR2	HVR2	NNP
cord-316534-ep7ezoko	314	24	or	or	CC
cord-316534-ep7ezoko	314	25	HVR5	HVR5	NNP
cord-316534-ep7ezoko	314	26	of	of	IN
cord-316534-ep7ezoko	314	27	Ad5	ad5	CD
cord-316534-ep7ezoko	314	28	hexon	hexon	NNP
cord-316534-ep7ezoko	314	29	.	.	.
cord-316534-ep7ezoko	315	1	We	-PRON-	PRP
cord-316534-ep7ezoko	315	2	incorporated	incorporate	VBD
cord-316534-ep7ezoko	315	3	identical	identical	JJ
cord-316534-ep7ezoko	315	4	epitopes	epitope	NNS
cord-316534-ep7ezoko	315	5	ranging	range	VBG
cord-316534-ep7ezoko	315	6	from	from	IN
cord-316534-ep7ezoko	315	7	33	33	CD
cord-316534-ep7ezoko	315	8	to	to	TO
cord-316534-ep7ezoko	315	9	83	83	CD
cord-316534-ep7ezoko	315	10	amino	amino	NN
cord-316534-ep7ezoko	315	11	acids	acid	NNS
cord-316534-ep7ezoko	315	12	within	within	IN
cord-316534-ep7ezoko	315	13	the	the	DT
cord-316534-ep7ezoko	315	14	Ad5	ad5	CD
cord-316534-ep7ezoko	315	15	hexon	hexon	NNP
cord-316534-ep7ezoko	315	16	HVR2	HVR2	NNP
cord-316534-ep7ezoko	315	17	or	or	CC
cord-316534-ep7ezoko	315	18	HVR5	HVR5	NNP
cord-316534-ep7ezoko	315	19	region	region	NN
cord-316534-ep7ezoko	315	20	.	.	.
cord-316534-ep7ezoko	316	1	Viable	viable	JJ
cord-316534-ep7ezoko	316	2	viruses	virus	NNS
cord-316534-ep7ezoko	316	3	were	be	VBD
cord-316534-ep7ezoko	316	4	produced	produce	VBN
cord-316534-ep7ezoko	316	5	with	with	IN
cord-316534-ep7ezoko	316	6	incorporations	incorporation	NNS
cord-316534-ep7ezoko	316	7	of	of	IN
cord-316534-ep7ezoko	316	8	33	33	CD
cord-316534-ep7ezoko	316	9	amino	amino	NN
cord-316534-ep7ezoko	316	10	acids	acid	NNS
cord-316534-ep7ezoko	316	11	plus	plus	CC
cord-316534-ep7ezoko	316	12	a	a	DT
cord-316534-ep7ezoko	316	13	12-amino	12-amino	CD
cord-316534-ep7ezoko	316	14	acid	acid	NN
cord-316534-ep7ezoko	316	15	linker	linker	NN
cord-316534-ep7ezoko	316	16	at	at	IN
cord-316534-ep7ezoko	316	17	HVR2	HVR2	NNP
cord-316534-ep7ezoko	316	18	or	or	CC
cord-316534-ep7ezoko	316	19	HVR5	HVR5	NNP
cord-316534-ep7ezoko	316	20	.	.	.
cord-316534-ep7ezoko	317	1	In	in	IN
cord-316534-ep7ezoko	317	2	addition	addition	NN
cord-316534-ep7ezoko	317	3	,	,	,
cord-316534-ep7ezoko	317	4	viable	viable	JJ
cord-316534-ep7ezoko	317	5	viruses	virus	NNS
cord-316534-ep7ezoko	317	6	were	be	VBD
cord-316534-ep7ezoko	317	7	produced	produce	VBN
cord-316534-ep7ezoko	317	8	with	with	IN
cord-316534-ep7ezoko	317	9	incorporations	incorporation	NNS
cord-316534-ep7ezoko	317	10	of	of	IN
cord-316534-ep7ezoko	317	11	up	up	IN
cord-316534-ep7ezoko	317	12	to	to	TO
cord-316534-ep7ezoko	317	13	53	53	CD
cord-316534-ep7ezoko	317	14	amino	amino	JJ
cord-316534-ep7ezoko	317	15	acids	acid	NNS
cord-316534-ep7ezoko	317	16	plus	plus	CC
cord-316534-ep7ezoko	317	17	a	a	DT
cord-316534-ep7ezoko	317	18	12-amino	12-amino	CD
cord-316534-ep7ezoko	317	19	acid	acid	NN
cord-316534-ep7ezoko	317	20	linker	linker	NN
cord-316534-ep7ezoko	317	21	at	at	IN
cord-316534-ep7ezoko	317	22	HVR5	HVR5	NNP
cord-316534-ep7ezoko	317	23	.	.	.
cord-316534-ep7ezoko	318	1	With	with	IN
cord-316534-ep7ezoko	318	2	respect	respect	NN
cord-316534-ep7ezoko	318	3	to	to	IN
cord-316534-ep7ezoko	318	4	identical	identical	JJ
cord-316534-ep7ezoko	318	5	antigen	antigen	NN
cord-316534-ep7ezoko	318	6	incorporations	incorporation	NNS
cord-316534-ep7ezoko	318	7	at	at	IN
cord-316534-ep7ezoko	318	8	Ad5	ad5	CD
cord-316534-ep7ezoko	318	9	HVR2	HVR2	NNP
cord-316534-ep7ezoko	318	10	or	or	CC
cord-316534-ep7ezoko	318	11	HVR5	HVR5	NNP
cord-316534-ep7ezoko	318	12	,	,	,
cord-316534-ep7ezoko	318	13	HVR5	HVR5	NNP
cord-316534-ep7ezoko	318	14	was	be	VBD
cord-316534-ep7ezoko	318	15	more	more	RBR
cord-316534-ep7ezoko	318	16	permissive	permissive	JJ
cord-316534-ep7ezoko	318	17	allowing	allow	VBG
cord-316534-ep7ezoko	318	18	an	an	DT
cord-316534-ep7ezoko	318	19	epitope	epitope	NN
cord-316534-ep7ezoko	318	20	incorporation	incorporation	NN
cord-316534-ep7ezoko	318	21	of	of	IN
cord-316534-ep7ezoko	318	22	65	65	CD
cord-316534-ep7ezoko	318	23	amino	amino	JJ
cord-316534-ep7ezoko	318	24	acids	acid	NNS
cord-316534-ep7ezoko	318	25	in	in	IN
cord-316534-ep7ezoko	318	26	total	total	NN
cord-316534-ep7ezoko	318	27	.	.	.
cord-316534-ep7ezoko	319	1	These	these	DT
cord-316534-ep7ezoko	319	2	model	model	NN
cord-316534-ep7ezoko	319	3	antigens	antigen	NNS
cord-316534-ep7ezoko	319	4	were	be	VBD
cord-316534-ep7ezoko	319	5	surface	surface	NN
cord-316534-ep7ezoko	319	6	exposed	expose	VBN
cord-316534-ep7ezoko	319	7	via	via	IN
cord-316534-ep7ezoko	319	8	ELISA	ELISA	NNP
cord-316534-ep7ezoko	319	9	analysis	analysis	NN
cord-316534-ep7ezoko	319	10	.	.	.
cord-316534-ep7ezoko	320	1	In	in	IN
cord-316534-ep7ezoko	320	2	vivo	vivo	NN
cord-316534-ep7ezoko	320	3	immunization	immunization	NN
cord-316534-ep7ezoko	320	4	with	with	IN
cord-316534-ep7ezoko	320	5	these	these	DT
cord-316534-ep7ezoko	320	6	vectors	vector	NNS
cord-316534-ep7ezoko	320	7	illustrated	illustrate	VBD
cord-316534-ep7ezoko	320	8	an	an	DT
cord-316534-ep7ezoko	320	9	antigen	antigen	NN
cord-316534-ep7ezoko	320	10	-	-	HYPH
cord-316534-ep7ezoko	320	11	specific	specific	JJ
cord-316534-ep7ezoko	320	12	immune	immune	JJ
cord-316534-ep7ezoko	320	13	response	response	NN
cord-316534-ep7ezoko	320	14	.	.	.
cord-316534-ep7ezoko	321	1	240	240	CD
cord-316534-ep7ezoko	322	1	Along	along	IN
cord-316534-ep7ezoko	322	2	these	these	DT
cord-316534-ep7ezoko	322	3	same	same	JJ
cord-316534-ep7ezoko	322	4	lines	line	NNS
cord-316534-ep7ezoko	322	5	,	,	,
cord-316534-ep7ezoko	322	6	Abe	Abe	NNP
cord-316534-ep7ezoko	322	7	and	and	CC
cord-316534-ep7ezoko	322	8	colleagues	colleague	NNS
cord-316534-ep7ezoko	322	9	evaluated	evaluate	VBD
cord-316534-ep7ezoko	322	10	the	the	DT
cord-316534-ep7ezoko	322	11	ability	ability	NN
cord-316534-ep7ezoko	322	12	of	of	IN
cord-316534-ep7ezoko	322	13	Ad5-based	ad5-based	JJ
cord-316534-ep7ezoko	322	14	vectors	vector	NNS
cord-316534-ep7ezoko	322	15	expressing	express	VBG
cord-316534-ep7ezoko	322	16	an	an	DT
cord-316534-ep7ezoko	322	17	HIV	HIV	NNP
cord-316534-ep7ezoko	322	18	transgene	transgene	NN
cord-316534-ep7ezoko	322	19	to	to	TO
cord-316534-ep7ezoko	322	20	induce	induce	VB
cord-316534-ep7ezoko	322	21	antigen	antigen	NN
cord-316534-ep7ezoko	322	22	-	-	HYPH
cord-316534-ep7ezoko	322	23	specific	specific	JJ
cord-316534-ep7ezoko	322	24	immune	immune	JJ
cord-316534-ep7ezoko	322	25	responses	response	NNS
cord-316534-ep7ezoko	322	26	under	under	IN
cord-316534-ep7ezoko	322	27	Ad5	ad5	CD
cord-316534-ep7ezoko	322	28	preimmune	preimmune	NNP
cord-316534-ep7ezoko	322	29	conditions	condition	NNS
cord-316534-ep7ezoko	322	30	.	.	.
cord-316534-ep7ezoko	323	1	To	to	TO
cord-316534-ep7ezoko	323	2	overcome	overcome	VB
cord-316534-ep7ezoko	323	3	limitations	limitation	NNS
cord-316534-ep7ezoko	323	4	that	that	WDT
cord-316534-ep7ezoko	323	5	are	be	VBP
cord-316534-ep7ezoko	323	6	generally	generally	RB
cord-316534-ep7ezoko	323	7	experienced	experience	VBN
cord-316534-ep7ezoko	323	8	as	as	IN
cord-316534-ep7ezoko	323	9	a	a	DT
cord-316534-ep7ezoko	323	10	result	result	NN
cord-316534-ep7ezoko	323	11	of	of	IN
cord-316534-ep7ezoko	323	12	PEI	PEI	NNP
cord-316534-ep7ezoko	323	13	to	to	IN
cord-316534-ep7ezoko	323	14	Ad5	ad5	CD
cord-316534-ep7ezoko	323	15	,	,	,
cord-316534-ep7ezoko	323	16	they	-PRON-	PRP
cord-316534-ep7ezoko	323	17	constructed	construct	VBD
cord-316534-ep7ezoko	323	18	vectors	vector	NNS
cord-316534-ep7ezoko	323	19	that	that	WDT
cord-316534-ep7ezoko	323	20	have	have	VBP
cord-316534-ep7ezoko	323	21	a	a	DT
cord-316534-ep7ezoko	323	22	modification	modification	NN
cord-316534-ep7ezoko	323	23	in	in	IN
cord-316534-ep7ezoko	323	24	the	the	DT
cord-316534-ep7ezoko	323	25	HVR5	HVR5	NNP
cord-316534-ep7ezoko	323	26	.	.	.
cord-316534-ep7ezoko	324	1	Their	-PRON-	PRP$
cord-316534-ep7ezoko	324	2	study	study	NN
cord-316534-ep7ezoko	324	3	characterized	characterize	VBD
cord-316534-ep7ezoko	324	4	various	various	JJ
cord-316534-ep7ezoko	324	5	immunological	immunological	JJ
cord-316534-ep7ezoko	324	6	parameters	parameter	NNS
cord-316534-ep7ezoko	324	7	generated	generate	VBN
cord-316534-ep7ezoko	324	8	by	by	IN
cord-316534-ep7ezoko	324	9	these	these	DT
cord-316534-ep7ezoko	324	10	vectors	vector	NNS
cord-316534-ep7ezoko	324	11	such	such	JJ
cord-316534-ep7ezoko	324	12	as	as	IN
cord-316534-ep7ezoko	324	13	vector	vector	NN
cord-316534-ep7ezoko	324	14	neutralization	neutralization	NN
cord-316534-ep7ezoko	324	15	,	,	,
cord-316534-ep7ezoko	324	16	acquisition	acquisition	NN
cord-316534-ep7ezoko	324	17	of	of	IN
cord-316534-ep7ezoko	324	18	adaptive	adaptive	JJ
cord-316534-ep7ezoko	324	19	immune	immune	JJ
cord-316534-ep7ezoko	324	20	response	response	NN
cord-316534-ep7ezoko	324	21	,	,	,
cord-316534-ep7ezoko	324	22	and	and	CC
cord-316534-ep7ezoko	324	23	comparison	comparison	NN
cord-316534-ep7ezoko	324	24	of	of	IN
cord-316534-ep7ezoko	324	25	protective	protective	JJ
cord-316534-ep7ezoko	324	26	immunity	immunity	NN
cord-316534-ep7ezoko	324	27	.	.	.
cord-316534-ep7ezoko	325	1	First	first	RB
cord-316534-ep7ezoko	325	2	,	,	,
cord-316534-ep7ezoko	325	3	in	in	IN
cord-316534-ep7ezoko	325	4	order	order	NN
cord-316534-ep7ezoko	325	5	to	to	TO
cord-316534-ep7ezoko	325	6	evaluate	evaluate	VB
cord-316534-ep7ezoko	325	7	the	the	DT
cord-316534-ep7ezoko	325	8	utility	utility	NN
cord-316534-ep7ezoko	325	9	of	of	IN
cord-316534-ep7ezoko	325	10	the	the	DT
cord-316534-ep7ezoko	325	11	modified	modify	VBN
cord-316534-ep7ezoko	325	12	Ad	ad	NN
cord-316534-ep7ezoko	325	13	vector	vector	NN
cord-316534-ep7ezoko	325	14	,	,	,
cord-316534-ep7ezoko	325	15	they	-PRON-	PRP
cord-316534-ep7ezoko	325	16	measured	measure	VBD
cord-316534-ep7ezoko	325	17	the	the	DT
cord-316534-ep7ezoko	325	18	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	325	19	activity	activity	NN
cord-316534-ep7ezoko	325	20	of	of	IN
cord-316534-ep7ezoko	325	21	sera	sera	NNP
cord-316534-ep7ezoko	325	22	by	by	IN
cord-316534-ep7ezoko	325	23	a	a	DT
cord-316534-ep7ezoko	325	24	modified	modify	VBN
cord-316534-ep7ezoko	325	25	Ad	ad	NN
cord-316534-ep7ezoko	325	26	vector	vector	NN
cord-316534-ep7ezoko	325	27	.	.	.
cord-316534-ep7ezoko	326	1	They	-PRON-	PRP
cord-316534-ep7ezoko	326	2	administered	administer	VBD
cord-316534-ep7ezoko	326	3	Ad	Ad	NNP
cord-316534-ep7ezoko	326	4	-	-	HYPH
cord-316534-ep7ezoko	326	5	Luc	Luc	NNP
cord-316534-ep7ezoko	326	6	(	(	-LRB-
cord-316534-ep7ezoko	326	7	luciferase	luciferase	NN
cord-316534-ep7ezoko	326	8	protein	protein	NN
cord-316534-ep7ezoko	326	9	expressed	express	VBD
cord-316534-ep7ezoko	326	10	as	as	IN
cord-316534-ep7ezoko	326	11	a	a	DT
cord-316534-ep7ezoko	326	12	transgene	transgene	NN
cord-316534-ep7ezoko	326	13	in	in	IN
cord-316534-ep7ezoko	326	14	the	the	DT
cord-316534-ep7ezoko	326	15	Ad	ad	NN
cord-316534-ep7ezoko	326	16	E1	e1	NN
cord-316534-ep7ezoko	326	17	region	region	NN
cord-316534-ep7ezoko	326	18	)	)	-RRB-
cord-316534-ep7ezoko	326	19	,	,	,
cord-316534-ep7ezoko	326	20	Ad	Ad	NNP
cord-316534-ep7ezoko	326	21	-	-	HYPH
cord-316534-ep7ezoko	326	22	HisLuc	HisLuc	NNP
cord-316534-ep7ezoko	326	23	(	(	-LRB-
cord-316534-ep7ezoko	326	24	His	-PRON-	PRP$
cord-316534-ep7ezoko	326	25	6	6	CD
cord-316534-ep7ezoko	326	26	epitope	epitope	NN
cord-316534-ep7ezoko	326	27	presented	present	VBN
cord-316534-ep7ezoko	326	28	in	in	IN
cord-316534-ep7ezoko	326	29	HVR5	HVR5	NNP
cord-316534-ep7ezoko	326	30	region	region	NN
cord-316534-ep7ezoko	326	31	and	and	CC
cord-316534-ep7ezoko	326	32	luciferase	luciferase	NN
cord-316534-ep7ezoko	326	33	protein	protein	NN
cord-316534-ep7ezoko	326	34	expressed	express	VBD
cord-316534-ep7ezoko	326	35	as	as	IN
cord-316534-ep7ezoko	326	36	a	a	DT
cord-316534-ep7ezoko	326	37	transgene	transgene	NN
cord-316534-ep7ezoko	326	38	)	)	-RRB-
cord-316534-ep7ezoko	326	39	,	,	,
cord-316534-ep7ezoko	326	40	or	or	CC
cord-316534-ep7ezoko	326	41	Ad	ad	NN
cord-316534-ep7ezoko	326	42	-	-	HYPH
cord-316534-ep7ezoko	326	43	END/	END/	NNP
cord-316534-ep7ezoko	327	1	AAALuc	aaaluc	NN
cord-316534-ep7ezoko	327	2	vector	vector	NN
cord-316534-ep7ezoko	327	3	(	(	-LRB-
cord-316534-ep7ezoko	327	4	containing	contain	VBG
cord-316534-ep7ezoko	327	5	three	three	CD
cord-316534-ep7ezoko	327	6	amino	amino	NN
cord-316534-ep7ezoko	327	7	acid	acid	NN
cord-316534-ep7ezoko	327	8	mutations	mutation	NNS
cord-316534-ep7ezoko	327	9	in	in	IN
cord-316534-ep7ezoko	327	10	HVR5	HVR5	NNP
cord-316534-ep7ezoko	327	11	and	and	CC
cord-316534-ep7ezoko	327	12	expressing	express	VBG
cord-316534-ep7ezoko	327	13	luciferase	luciferase	NN
cord-316534-ep7ezoko	327	14	protein	protein	NN
cord-316534-ep7ezoko	327	15	)	)	-RRB-
cord-316534-ep7ezoko	327	16	to	to	IN
cord-316534-ep7ezoko	327	17	mice	mouse	NNS
cord-316534-ep7ezoko	327	18	IM	im	JJ
cord-316534-ep7ezoko	327	19	.	.	.
cord-316534-ep7ezoko	328	1	After	after	IN
cord-316534-ep7ezoko	328	2	administration	administration	NN
cord-316534-ep7ezoko	328	3	of	of	IN
cord-316534-ep7ezoko	328	4	these	these	DT
cord-316534-ep7ezoko	328	5	vectors	vector	NNS
cord-316534-ep7ezoko	328	6	,	,	,
cord-316534-ep7ezoko	328	7	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	328	8	activity	activity	NN
cord-316534-ep7ezoko	328	9	against	against	IN
cord-316534-ep7ezoko	328	10	Ad5	Ad5	NNP
cord-316534-ep7ezoko	328	11	was	be	VBD
cord-316534-ep7ezoko	328	12	observed	observe	VBN
cord-316534-ep7ezoko	328	13	for	for	IN
cord-316534-ep7ezoko	328	14	0	0	CD
cord-316534-ep7ezoko	328	15	-	-	SYM
cord-316534-ep7ezoko	328	16	8	8	CD
cord-316534-ep7ezoko	328	17	weeks	week	NNS
cord-316534-ep7ezoko	328	18	.	.	.
cord-316534-ep7ezoko	329	1	The	the	DT
cord-316534-ep7ezoko	329	2	hexon	hexon	NN
cord-316534-ep7ezoko	329	3	-	-	HYPH
cord-316534-ep7ezoko	329	4	modified	modify	VBN
cord-316534-ep7ezoko	329	5	vector	vector	NN
cord-316534-ep7ezoko	329	6	(	(	-LRB-
cord-316534-ep7ezoko	329	7	Ad	Ad	NNP
cord-316534-ep7ezoko	329	8	-	-	HYPH
cord-316534-ep7ezoko	329	9	HisLuc	HisLuc	NNP
cord-316534-ep7ezoko	329	10	)	)	-RRB-
cord-316534-ep7ezoko	329	11	generated	generate	VBD
cord-316534-ep7ezoko	329	12	the	the	DT
cord-316534-ep7ezoko	329	13	lowest	low	JJS
cord-316534-ep7ezoko	329	14	Ad5-specific	Ad5-specific	NNP
cord-316534-ep7ezoko	329	15	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	329	16	activity	activity	NN
cord-316534-ep7ezoko	329	17	,	,	,
cord-316534-ep7ezoko	329	18	which	which	WDT
cord-316534-ep7ezoko	329	19	was	be	VBD
cord-316534-ep7ezoko	329	20	significantly	significantly	RB
cord-316534-ep7ezoko	329	21	lower	low	JJR
cord-316534-ep7ezoko	329	22	than	than	IN
cord-316534-ep7ezoko	329	23	what	what	WP
cord-316534-ep7ezoko	329	24	was	be	VBD
cord-316534-ep7ezoko	329	25	generated	generate	VBN
cord-316534-ep7ezoko	329	26	by	by	IN
cord-316534-ep7ezoko	329	27	Ad	Ad	NNP
cord-316534-ep7ezoko	329	28	-	-	HYPH
cord-316534-ep7ezoko	329	29	Luc	Luc	NNP
cord-316534-ep7ezoko	329	30	at	at	IN
cord-316534-ep7ezoko	329	31	weeks	week	NNS
cord-316534-ep7ezoko	329	32	6	6	CD
cord-316534-ep7ezoko	329	33	and	and	CC
cord-316534-ep7ezoko	329	34	8	8	CD
cord-316534-ep7ezoko	329	35	,	,	,
cord-316534-ep7ezoko	329	36	and	and	CC
cord-316534-ep7ezoko	329	37	by	by	IN
cord-316534-ep7ezoko	329	38	Ad	Ad	NNP
cord-316534-ep7ezoko	329	39	-	-	HYPH
cord-316534-ep7ezoko	329	40	End/	End/	NNP
cord-316534-ep7ezoko	330	1	AAALuc	aaaluc	NN
cord-316534-ep7ezoko	330	2	vector	vector	NN
cord-316534-ep7ezoko	330	3	at	at	IN
cord-316534-ep7ezoko	330	4	week	week	NN
cord-316534-ep7ezoko	330	5	8	8	CD
cord-316534-ep7ezoko	330	6	.	.	.
cord-316534-ep7ezoko	331	1	The	the	DT
cord-316534-ep7ezoko	331	2	individual	individual	JJ
cord-316534-ep7ezoko	331	3	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	331	4	activity	activity	NN
cord-316534-ep7ezoko	331	5	of	of	IN
cord-316534-ep7ezoko	331	6	Ad	ad	NN
cord-316534-ep7ezoko	331	7	-	-	HYPH
cord-316534-ep7ezoko	331	8	HisLuc	HisLuc	NNP
cord-316534-ep7ezoko	331	9	immunization	immunization	NN
cord-316534-ep7ezoko	331	10	was	be	VBD
cord-316534-ep7ezoko	331	11	significantly	significantly	RB
cord-316534-ep7ezoko	331	12	lower	low	JJR
cord-316534-ep7ezoko	331	13	than	than	IN
cord-316534-ep7ezoko	331	14	that	that	DT
cord-316534-ep7ezoko	331	15	of	of	IN
cord-316534-ep7ezoko	331	16	Ad	Ad	NNP
cord-316534-ep7ezoko	331	17	-	-	HYPH
cord-316534-ep7ezoko	331	18	Luc	Luc	NNP
cord-316534-ep7ezoko	331	19	immunization	immunization	NN
cord-316534-ep7ezoko	331	20	.	.	.
cord-316534-ep7ezoko	332	1	Additional	additional	JJ
cord-316534-ep7ezoko	332	2	studies	study	NNS
cord-316534-ep7ezoko	332	3	performed	perform	VBN
cord-316534-ep7ezoko	332	4	by	by	IN
cord-316534-ep7ezoko	332	5	Abe	Abe	NNP
cord-316534-ep7ezoko	332	6	and	and	CC
cord-316534-ep7ezoko	332	7	colleagues	colleague	NNS
cord-316534-ep7ezoko	332	8	support	support	VBP
cord-316534-ep7ezoko	332	9	the	the	DT
cord-316534-ep7ezoko	332	10	concept	concept	NN
cord-316534-ep7ezoko	332	11	that	that	IN
cord-316534-ep7ezoko	332	12	modified	modify	VBN
cord-316534-ep7ezoko	332	13	hexon	hexon	NN
cord-316534-ep7ezoko	332	14	thwarts	thwart	VBZ
cord-316534-ep7ezoko	332	15	Ad5	ad5	CD
cord-316534-ep7ezoko	332	16	Nabs	Nabs	NNP
cord-316534-ep7ezoko	332	17	and	and	CC
cord-316534-ep7ezoko	332	18	promotes	promote	VBZ
cord-316534-ep7ezoko	332	19	cellular	cellular	JJ
cord-316534-ep7ezoko	332	20	immune	immune	JJ
cord-316534-ep7ezoko	332	21	responses	response	NNS
cord-316534-ep7ezoko	332	22	.	.	.
cord-316534-ep7ezoko	333	1	247	247	CD
cord-316534-ep7ezoko	333	2	Studies	study	NNS
cord-316534-ep7ezoko	333	3	performed	perform	VBN
cord-316534-ep7ezoko	333	4	by	by	IN
cord-316534-ep7ezoko	333	5	this	this	DT
cord-316534-ep7ezoko	333	6	research	research	NN
cord-316534-ep7ezoko	333	7	group	group	NN
cord-316534-ep7ezoko	333	8	indicate	indicate	VBP
cord-316534-ep7ezoko	333	9	that	that	IN
cord-316534-ep7ezoko	333	10	a	a	DT
cord-316534-ep7ezoko	333	11	change	change	NN
cord-316534-ep7ezoko	333	12	in	in	IN
cord-316534-ep7ezoko	333	13	the	the	DT
cord-316534-ep7ezoko	333	14	immunogenic	immunogenic	JJ
cord-316534-ep7ezoko	333	15	epitope	epitope	NN
cord-316534-ep7ezoko	333	16	is	be	VBZ
cord-316534-ep7ezoko	333	17	necessary	necessary	JJ
cord-316534-ep7ezoko	333	18	to	to	TO
cord-316534-ep7ezoko	333	19	avoid	avoid	VB
cord-316534-ep7ezoko	333	20	neutralization	neutralization	NN
cord-316534-ep7ezoko	333	21	by	by	IN
cord-316534-ep7ezoko	333	22	pre	pre	JJ
cord-316534-ep7ezoko	333	23	-	-	JJ
cord-316534-ep7ezoko	333	24	existing	existing	JJ
cord-316534-ep7ezoko	333	25	Nabs	Nabs	NNP
cord-316534-ep7ezoko	333	26	.	.	.
cord-316534-ep7ezoko	334	1	Our	-PRON-	PRP$
cord-316534-ep7ezoko	334	2	recently	recently	RB
cord-316534-ep7ezoko	334	3	published	publish	VBN
cord-316534-ep7ezoko	334	4	work	work	NN
cord-316534-ep7ezoko	334	5	exploits	exploit	VBZ
cord-316534-ep7ezoko	334	6	the	the	DT
cord-316534-ep7ezoko	334	7	antigen	antigen	NN
cord-316534-ep7ezoko	334	8	capsidincorporation	capsidincorporation	NN
cord-316534-ep7ezoko	334	9	strategy	strategy	NN
cord-316534-ep7ezoko	334	10	for	for	IN
cord-316534-ep7ezoko	334	11	HIV	HIV	NNP
cord-316534-ep7ezoko	334	12	vaccination	vaccination	NN
cord-316534-ep7ezoko	334	13	.	.	.
cord-316534-ep7ezoko	335	1	Our	-PRON-	PRP$
cord-316534-ep7ezoko	335	2	novel	novel	NN
cord-316534-ep7ezoko	335	3	vectors	vector	NNS
cord-316534-ep7ezoko	335	4	were	be	VBD
cord-316534-ep7ezoko	335	5	constructed	construct	VBN
cord-316534-ep7ezoko	335	6	in	in	IN
cord-316534-ep7ezoko	335	7	hopes	hope	NNS
cord-316534-ep7ezoko	335	8	of	of	IN
cord-316534-ep7ezoko	335	9	moving	move	VBG
cord-316534-ep7ezoko	335	10	toward	toward	IN
cord-316534-ep7ezoko	335	11	the	the	DT
cord-316534-ep7ezoko	335	12	goal	goal	NN
cord-316534-ep7ezoko	335	13	of	of	IN
cord-316534-ep7ezoko	335	14	creating	create	VBG
cord-316534-ep7ezoko	335	15	vectors	vector	NNS
cord-316534-ep7ezoko	335	16	that	that	WDT
cord-316534-ep7ezoko	335	17	will	will	MD
cord-316534-ep7ezoko	335	18	provide	provide	VB
cord-316534-ep7ezoko	335	19	cellular	cellular	JJ
cord-316534-ep7ezoko	335	20	and	and	CC
cord-316534-ep7ezoko	335	21	humoral	humoral	JJ
cord-316534-ep7ezoko	335	22	HIV	HIV	NNP
cord-316534-ep7ezoko	335	23	immunity	immunity	NN
cord-316534-ep7ezoko	335	24	.	.	.
cord-316534-ep7ezoko	336	1	Our	-PRON-	PRP$
cord-316534-ep7ezoko	336	2	study	study	NN
cord-316534-ep7ezoko	336	3	is	be	VBZ
cord-316534-ep7ezoko	336	4	the	the	DT
cord-316534-ep7ezoko	336	5	first	first	JJ
cord-316534-ep7ezoko	336	6	of	of	IN
cord-316534-ep7ezoko	336	7	its	-PRON-	PRP$
cord-316534-ep7ezoko	336	8	kind	kind	NN
cord-316534-ep7ezoko	336	9	to	to	TO
cord-316534-ep7ezoko	336	10	genetically	genetically	RB
cord-316534-ep7ezoko	336	11	incorporate	incorporate	VB
cord-316534-ep7ezoko	336	12	an	an	DT
cord-316534-ep7ezoko	336	13	HIV	HIV	NNP
cord-316534-ep7ezoko	336	14	antigen	antigen	NN
cord-316534-ep7ezoko	336	15	within	within	IN
cord-316534-ep7ezoko	336	16	the	the	DT
cord-316534-ep7ezoko	336	17	Ad5	ad5	CD
cord-316534-ep7ezoko	336	18	hexon	hexon	NNP
cord-316534-ep7ezoko	336	19	HVR2	HVR2	NNP
cord-316534-ep7ezoko	336	20	alone	alone	RB
cord-316534-ep7ezoko	336	21	or	or	CC
cord-316534-ep7ezoko	336	22	in	in	IN
cord-316534-ep7ezoko	336	23	combination	combination	NN
cord-316534-ep7ezoko	336	24	with	with	IN
cord-316534-ep7ezoko	336	25	genomic	genomic	JJ
cord-316534-ep7ezoko	336	26	incorporation	incorporation	NN
cord-316534-ep7ezoko	336	27	of	of	IN
cord-316534-ep7ezoko	336	28	a	a	DT
cord-316534-ep7ezoko	336	29	Gag	Gag	NNP
cord-316534-ep7ezoko	336	30	transgene	transgene	NN
cord-316534-ep7ezoko	336	31	(	(	-LRB-
cord-316534-ep7ezoko	336	32	Ad5	Ad5	NNP
cord-316534-ep7ezoko	336	33	/	/	SYM
cord-316534-ep7ezoko	336	34	HVR2-MPER	hvr2-mper	NN
cord-316534-ep7ezoko	336	35	-	-	HYPH
cord-316534-ep7ezoko	336	36	L15(Gag	l15(gag	NN
cord-316534-ep7ezoko	336	37	)	)	-RRB-
cord-316534-ep7ezoko	336	38	)	)	-RRB-
cord-316534-ep7ezoko	336	39	.	.	.
cord-316534-ep7ezoko	337	1	In	in	IN
cord-316534-ep7ezoko	337	2	this	this	DT
cord-316534-ep7ezoko	337	3	study	study	NN
cord-316534-ep7ezoko	337	4	,	,	,
cord-316534-ep7ezoko	337	5	we	-PRON-	PRP
cord-316534-ep7ezoko	337	6	successfully	successfully	RB
cord-316534-ep7ezoko	337	7	incorporated	incorporate	VBD
cord-316534-ep7ezoko	337	8	a	a	DT
cord-316534-ep7ezoko	337	9	24-amino	24-amino	CD
cord-316534-ep7ezoko	337	10	acid	acid	NN
cord-316534-ep7ezoko	337	11	epitope	epitope	NN
cord-316534-ep7ezoko	337	12	of	of	IN
cord-316534-ep7ezoko	337	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	337	14	within	within	IN
cord-316534-ep7ezoko	337	15	HVR2	HVR2	NNP
cord-316534-ep7ezoko	337	16	.	.	.
cord-316534-ep7ezoko	338	1	The	the	DT
cord-316534-ep7ezoko	338	2	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	338	3	region	region	NN
cord-316534-ep7ezoko	338	4	selected	select	VBN
cord-316534-ep7ezoko	338	5	for	for	IN
cord-316534-ep7ezoko	338	6	HVR2	HVR2	NNP
cord-316534-ep7ezoko	338	7	incorporation	incorporation	NN
cord-316534-ep7ezoko	338	8	was	be	VBD
cord-316534-ep7ezoko	338	9	the	the	DT
cord-316534-ep7ezoko	338	10	membrane	membrane	NN
cord-316534-ep7ezoko	338	11	proximal	proximal	JJ
cord-316534-ep7ezoko	338	12	ectodomain	ectodomain	NN
cord-316534-ep7ezoko	338	13	region	region	NN
cord-316534-ep7ezoko	338	14	(	(	-LRB-
cord-316534-ep7ezoko	338	15	MPER	MPER	NNP
cord-316534-ep7ezoko	338	16	)	)	-RRB-
cord-316534-ep7ezoko	338	17	derived	derive	VBN
cord-316534-ep7ezoko	338	18	from	from	IN
cord-316534-ep7ezoko	338	19	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	338	20	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	338	21	41	41	CD
cord-316534-ep7ezoko	338	22	(	(	-LRB-
cord-316534-ep7ezoko	338	23	gp41	gp41	NNP
cord-316534-ep7ezoko	338	24	)	)	-RRB-
cord-316534-ep7ezoko	338	25	.	.	.
cord-316534-ep7ezoko	339	1	Our	-PRON-	PRP$
cord-316534-ep7ezoko	339	2	rationale	rationale	NN
cord-316534-ep7ezoko	339	3	for	for	IN
cord-316534-ep7ezoko	339	4	choosing	choose	VBG
cord-316534-ep7ezoko	339	5	a	a	DT
cord-316534-ep7ezoko	339	6	portion	portion	NN
cord-316534-ep7ezoko	339	7	of	of	IN
cord-316534-ep7ezoko	339	8	the	the	DT
cord-316534-ep7ezoko	339	9	MPER	MPER	NNP
cord-316534-ep7ezoko	339	10	(	(	-LRB-
cord-316534-ep7ezoko	339	11	EKNEKEL	EKNEKEL	NNP
cord-316534-ep7ezoko	339	12	-	-	HYPH
cord-316534-ep7ezoko	339	13	LELDKWASLWNWFDITN	LELDKWASLWNWFDITN	NNP
cord-316534-ep7ezoko	339	14	)	)	-RRB-
cord-316534-ep7ezoko	339	15	derived	derive	VBD
cord-316534-ep7ezoko	339	16	from	from	IN
cord-316534-ep7ezoko	339	17	gp41	gp41	NNP
cord-316534-ep7ezoko	339	18	was	be	VBD
cord-316534-ep7ezoko	339	19	based	base	VBN
cord-316534-ep7ezoko	339	20	on	on	IN
cord-316534-ep7ezoko	339	21	the	the	DT
cord-316534-ep7ezoko	339	22	fact	fact	NN
cord-316534-ep7ezoko	339	23	that	that	IN
cord-316534-ep7ezoko	339	24	the	the	DT
cord-316534-ep7ezoko	339	25	gp41	gp41	NNP
cord-316534-ep7ezoko	339	26	envelope	envelope	NN
cord-316534-ep7ezoko	339	27	protein	protein	NN
cord-316534-ep7ezoko	339	28	ectodomain	ectodomain	NNP
cord-316534-ep7ezoko	339	29	is	be	VBZ
cord-316534-ep7ezoko	339	30	a	a	DT
cord-316534-ep7ezoko	339	31	target	target	NN
cord-316534-ep7ezoko	339	32	of	of	IN
cord-316534-ep7ezoko	339	33	three	three	CD
cord-316534-ep7ezoko	339	34	broadly	broadly	RB
cord-316534-ep7ezoko	339	35	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	339	36	anti	anti	JJ
cord-316534-ep7ezoko	339	37	-	-	JJ
cord-316534-ep7ezoko	339	38	HIV-1	hiv-1	JJ
cord-316534-ep7ezoko	339	39	antibodies	antibody	NNS
cord-316534-ep7ezoko	339	40	.	.	.
cord-316534-ep7ezoko	340	1	248	248	CD
cord-316534-ep7ezoko	341	1	When	when	WRB
cord-316534-ep7ezoko	341	2	the	the	DT
cord-316534-ep7ezoko	341	3	MPER	MPER	NNP
cord-316534-ep7ezoko	341	4	was	be	VBD
cord-316534-ep7ezoko	341	5	incorporated	incorporate	VBN
cord-316534-ep7ezoko	341	6	into	into	IN
cord-316534-ep7ezoko	341	7	HVR2	HVR2	NNP
cord-316534-ep7ezoko	341	8	in	in	IN
cord-316534-ep7ezoko	341	9	combination	combination	NN
cord-316534-ep7ezoko	341	10	with	with	IN
cord-316534-ep7ezoko	341	11	transgene	transgene	JJ
cord-316534-ep7ezoko	341	12	expression	expression	NN
cord-316534-ep7ezoko	341	13	,	,	,
cord-316534-ep7ezoko	341	14	we	-PRON-	PRP
cord-316534-ep7ezoko	341	15	observed	observe	VBD
cord-316534-ep7ezoko	341	16	growth	growth	NN
cord-316534-ep7ezoko	341	17	kinetics	kinetic	NNS
cord-316534-ep7ezoko	341	18	and	and	CC
cord-316534-ep7ezoko	341	19	thermostability	thermostability	NN
cord-316534-ep7ezoko	341	20	changes	change	NNS
cord-316534-ep7ezoko	341	21	similar	similar	JJ
cord-316534-ep7ezoko	341	22	to	to	IN
cord-316534-ep7ezoko	341	23	those	those	DT
cord-316534-ep7ezoko	341	24	of	of	IN
cord-316534-ep7ezoko	341	25	other	other	JJ
cord-316534-ep7ezoko	341	26	capsid	capsid	RB
cord-316534-ep7ezoko	341	27	-	-	HYPH
cord-316534-ep7ezoko	341	28	incorporated	incorporate	VBN
cord-316534-ep7ezoko	341	29	vectors	vector	NNS
cord-316534-ep7ezoko	341	30	generated	generate	VBN
cord-316534-ep7ezoko	341	31	in	in	IN
cord-316534-ep7ezoko	341	32	other	other	JJ
cord-316534-ep7ezoko	341	33	studies	study	NNS
cord-316534-ep7ezoko	341	34	,	,	,
cord-316534-ep7ezoko	341	35	249	249	CD
cord-316534-ep7ezoko	341	36	,	,	,
cord-316534-ep7ezoko	341	37	250	250	CD
cord-316534-ep7ezoko	341	38	indicating	indicate	VBG
cord-316534-ep7ezoko	341	39	that	that	DT
cord-316534-ep7ezoko	341	40	incorporation	incorporation	NN
cord-316534-ep7ezoko	341	41	of	of	IN
cord-316534-ep7ezoko	341	42	the	the	DT
cord-316534-ep7ezoko	341	43	MPER	MPER	NNP
cord-316534-ep7ezoko	341	44	epitope	epitope	NN
cord-316534-ep7ezoko	341	45	within	within	IN
cord-316534-ep7ezoko	341	46	HVR2	HVR2	NNP
cord-316534-ep7ezoko	341	47	was	be	VBD
cord-316534-ep7ezoko	341	48	not	not	RB
cord-316534-ep7ezoko	341	49	dramatically	dramatically	RB
cord-316534-ep7ezoko	341	50	detrimental	detrimental	JJ
cord-316534-ep7ezoko	341	51	to	to	IN
cord-316534-ep7ezoko	341	52	virological	virological	JJ
cord-316534-ep7ezoko	341	53	characteristics	characteristic	NNS
cord-316534-ep7ezoko	341	54	.	.	.
cord-316534-ep7ezoko	342	1	250	250	CD
cord-316534-ep7ezoko	342	2	,	,	,
cord-316534-ep7ezoko	342	3	251	251	CD
cord-316534-ep7ezoko	343	1	In	in	IN
cord-316534-ep7ezoko	343	2	addition	addition	NN
cord-316534-ep7ezoko	343	3	,	,	,
cord-316534-ep7ezoko	343	4	we	-PRON-	PRP
cord-316534-ep7ezoko	343	5	demonstrated	demonstrate	VBD
cord-316534-ep7ezoko	343	6	that	that	IN
cord-316534-ep7ezoko	343	7	the	the	DT
cord-316534-ep7ezoko	343	8	MPER	MPER	NNP
cord-316534-ep7ezoko	343	9	epitope	epitope	NN
cord-316534-ep7ezoko	343	10	is	be	VBZ
cord-316534-ep7ezoko	343	11	surface	surface	NN
cord-316534-ep7ezoko	343	12	exposed	expose	VBN
cord-316534-ep7ezoko	343	13	within	within	IN
cord-316534-ep7ezoko	343	14	HVR2	HVR2	NNP
cord-316534-ep7ezoko	343	15	.	.	.
cord-316534-ep7ezoko	344	1	Most	most	RBS
cord-316534-ep7ezoko	344	2	importantly	importantly	RB
cord-316534-ep7ezoko	344	3	,	,	,
cord-316534-ep7ezoko	344	4	we	-PRON-	PRP
cord-316534-ep7ezoko	344	5	observed	observe	VBD
cord-316534-ep7ezoko	344	6	a	a	DT
cord-316534-ep7ezoko	344	7	humoral	humoral	JJ
cord-316534-ep7ezoko	344	8	anti	anti	JJ
cord-316534-ep7ezoko	344	9	-	-	JJ
cord-316534-ep7ezoko	344	10	HIV	hiv	JJ
cord-316534-ep7ezoko	344	11	response	response	NN
cord-316534-ep7ezoko	344	12	in	in	IN
cord-316534-ep7ezoko	344	13	mice	mouse	NNS
cord-316534-ep7ezoko	344	14	vaccinated	vaccinate	VBN
cord-316534-ep7ezoko	344	15	with	with	IN
cord-316534-ep7ezoko	344	16	the	the	DT
cord-316534-ep7ezoko	344	17	hexon	hexon	NN
cord-316534-ep7ezoko	344	18	-	-	HYPH
cord-316534-ep7ezoko	344	19	modified	modify	VBN
cord-316534-ep7ezoko	344	20	vector	vector	NN
cord-316534-ep7ezoko	344	21	.	.	.
cord-316534-ep7ezoko	345	1	The	the	DT
cord-316534-ep7ezoko	345	2	MPER	MPER	NNP
cord-316534-ep7ezoko	345	3	-	-	HYPH
cord-316534-ep7ezoko	345	4	modified	modify	VBN
cord-316534-ep7ezoko	345	5	vector	vector	NN
cord-316534-ep7ezoko	345	6	allows	allow	VBZ
cord-316534-ep7ezoko	345	7	boosting	boost	VBG
cord-316534-ep7ezoko	345	8	compared	compare	VBN
cord-316534-ep7ezoko	345	9	to	to	IN
cord-316534-ep7ezoko	345	10	AdCMVGag	adcmvgag	NN
cord-316534-ep7ezoko	345	11	,	,	,
cord-316534-ep7ezoko	345	12	possibly	possibly	RB
cord-316534-ep7ezoko	345	13	because	because	IN
cord-316534-ep7ezoko	345	14	the	the	DT
cord-316534-ep7ezoko	345	15	Ad5	Ad5	NNP
cord-316534-ep7ezoko	345	16	/	/	SYM
cord-316534-ep7ezoko	345	17	HVR2-MPER	hvr2-mper	NN
cord-316534-ep7ezoko	345	18	-	-	HYPH
cord-316534-ep7ezoko	345	19	L15(Gag	l15(gag	NN
cord-316534-ep7ezoko	345	20	)	)	-RRB-
cord-316534-ep7ezoko	346	1	Ad	ad	NN
cord-316534-ep7ezoko	346	2	elicits	elicit	VBZ
cord-316534-ep7ezoko	346	3	less	less	JJR
cord-316534-ep7ezoko	346	4	anti	anti	JJ
cord-316534-ep7ezoko	346	5	-	-	JJ
cord-316534-ep7ezoko	346	6	Ad5	ad5	JJ
cord-316534-ep7ezoko	346	7	immune	immune	JJ
cord-316534-ep7ezoko	346	8	response	response	NN
cord-316534-ep7ezoko	346	9	.	.	.
cord-316534-ep7ezoko	347	1	It	-PRON-	PRP
cord-316534-ep7ezoko	347	2	is	be	VBZ
cord-316534-ep7ezoko	347	3	possible	possible	JJ
cord-316534-ep7ezoko	347	4	that	that	IN
cord-316534-ep7ezoko	347	5	the	the	DT
cord-316534-ep7ezoko	347	6	MPER	MPER	NNP
cord-316534-ep7ezoko	347	7	epitope	epitope	NN
cord-316534-ep7ezoko	347	8	reduced	reduce	VBD
cord-316534-ep7ezoko	347	9	the	the	DT
cord-316534-ep7ezoko	347	10	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	347	11	of	of	IN
cord-316534-ep7ezoko	347	12	the	the	DT
cord-316534-ep7ezoko	347	13	Ad5	ad5	CD
cord-316534-ep7ezoko	347	14	vector	vector	NN
cord-316534-ep7ezoko	347	15	.	.	.
cord-316534-ep7ezoko	348	1	This	this	DT
cord-316534-ep7ezoko	348	2	finding	finding	NN
cord-316534-ep7ezoko	348	3	is	be	VBZ
cord-316534-ep7ezoko	348	4	noteworthy	noteworthy	JJ
cord-316534-ep7ezoko	348	5	because	because	IN
cord-316534-ep7ezoko	348	6	HVR2	HVR2	NNP
cord-316534-ep7ezoko	348	7	has	have	VBZ
cord-316534-ep7ezoko	348	8	not	not	RB
cord-316534-ep7ezoko	348	9	been	be	VBN
cord-316534-ep7ezoko	348	10	fully	fully	RB
cord-316534-ep7ezoko	348	11	explored	explore	VBN
cord-316534-ep7ezoko	348	12	for	for	IN
cord-316534-ep7ezoko	348	13	antigen	antigen	NN
cord-316534-ep7ezoko	348	14	capsid	capsid	NN
cord-316534-ep7ezoko	348	15	-	-	HYPH
cord-316534-ep7ezoko	348	16	incorporation	incorporation	NN
cord-316534-ep7ezoko	348	17	strategies	strategy	NNS
cord-316534-ep7ezoko	348	18	.	.	.
cord-316534-ep7ezoko	349	1	252	252	CD
cord-316534-ep7ezoko	350	1	These	these	DT
cord-316534-ep7ezoko	350	2	vectors	vector	NNS
cord-316534-ep7ezoko	350	3	are	be	VBP
cord-316534-ep7ezoko	350	4	currently	currently	RB
cord-316534-ep7ezoko	350	5	being	be	VBG
cord-316534-ep7ezoko	350	6	analyzed	analyze	VBN
cord-316534-ep7ezoko	350	7	by	by	IN
cord-316534-ep7ezoko	350	8	cryo	cryo	NN
cord-316534-ep7ezoko	350	9	-	-	HYPH
cord-316534-ep7ezoko	350	10	electron	electron	NN
cord-316534-ep7ezoko	350	11	microscopic	microscopic	JJ
cord-316534-ep7ezoko	350	12	analysis	analysis	NN
cord-316534-ep7ezoko	350	13	to	to	TO
cord-316534-ep7ezoko	350	14	determine	determine	VB
cord-316534-ep7ezoko	350	15	the	the	DT
cord-316534-ep7ezoko	350	16	critical	critical	JJ
cord-316534-ep7ezoko	350	17	correlates	correlate	NNS
cord-316534-ep7ezoko	350	18	related	relate	VBN
cord-316534-ep7ezoko	350	19	to	to	IN
cord-316534-ep7ezoko	350	20	antigen	antigen	NN
cord-316534-ep7ezoko	350	21	placement	placement	NN
cord-316534-ep7ezoko	350	22	/	/	SYM
cord-316534-ep7ezoko	350	23	configuration	configuration	NN
cord-316534-ep7ezoko	350	24	and	and	CC
cord-316534-ep7ezoko	350	25	immune	immune	JJ
cord-316534-ep7ezoko	350	26	response	response	NN
cord-316534-ep7ezoko	350	27	.	.	.
cord-316534-ep7ezoko	351	1	In	in	IN
cord-316534-ep7ezoko	351	2	addition	addition	NN
cord-316534-ep7ezoko	351	3	,	,	,
cord-316534-ep7ezoko	351	4	with	with	IN
cord-316534-ep7ezoko	351	5	respect	respect	NN
cord-316534-ep7ezoko	351	6	to	to	IN
cord-316534-ep7ezoko	351	7	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	351	8	vaccination	vaccination	NN
cord-316534-ep7ezoko	351	9	,	,	,
cord-316534-ep7ezoko	351	10	the	the	DT
cord-316534-ep7ezoko	351	11	antigen	antigen	NN
cord-316534-ep7ezoko	351	12	capsid	capsid	NN
cord-316534-ep7ezoko	351	13	-	-	HYPH
cord-316534-ep7ezoko	351	14	incorporation	incorporation	NN
cord-316534-ep7ezoko	351	15	strategy	strategy	NN
cord-316534-ep7ezoko	351	16	has	have	VBZ
cord-316534-ep7ezoko	351	17	been	be	VBN
cord-316534-ep7ezoko	351	18	evaluated	evaluate	VBN
cord-316534-ep7ezoko	351	19	within	within	IN
cord-316534-ep7ezoko	351	20	the	the	DT
cord-316534-ep7ezoko	351	21	context	context	NN
cord-316534-ep7ezoko	351	22	of	of	IN
cord-316534-ep7ezoko	351	23	HRV	HRV	NNP
cord-316534-ep7ezoko	351	24	.	.	.
cord-316534-ep7ezoko	352	1	Research	research	NN
cord-316534-ep7ezoko	352	2	groups	group	NNS
cord-316534-ep7ezoko	352	3	have	have	VBP
cord-316534-ep7ezoko	352	4	constructed	construct	VBN
cord-316534-ep7ezoko	352	5	human	human	JJ
cord-316534-ep7ezoko	352	6	rhinovirus	rhinovirus	NN
cord-316534-ep7ezoko	352	7	:	:	:
cord-316534-ep7ezoko	352	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	352	9	chimeras	chimera	NNS
cord-316534-ep7ezoko	352	10	in	in	IN
cord-316534-ep7ezoko	352	11	an	an	DT
cord-316534-ep7ezoko	352	12	effort	effort	NN
cord-316534-ep7ezoko	352	13	to	to	TO
cord-316534-ep7ezoko	352	14	stimulate	stimulate	VB
cord-316534-ep7ezoko	352	15	immunity	immunity	NN
cord-316534-ep7ezoko	352	16	against	against	IN
cord-316534-ep7ezoko	352	17	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	352	18	.	.	.
cord-316534-ep7ezoko	353	1	148	148	CD
cord-316534-ep7ezoko	353	2	,	,	,
cord-316534-ep7ezoko	353	3	253	253	CD
cord-316534-ep7ezoko	354	1	In	in	IN
cord-316534-ep7ezoko	354	2	an	an	DT
cord-316534-ep7ezoko	354	3	effort	effort	NN
cord-316534-ep7ezoko	354	4	to	to	TO
cord-316534-ep7ezoko	354	5	develop	develop	VB
cord-316534-ep7ezoko	354	6	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	354	7	vaccines	vaccine	NNS
cord-316534-ep7ezoko	354	8	,	,	,
cord-316534-ep7ezoko	354	9	researchers	researcher	NNS
cord-316534-ep7ezoko	354	10	within	within	IN
cord-316534-ep7ezoko	354	11	this	this	DT
cord-316534-ep7ezoko	354	12	same	same	JJ
cord-316534-ep7ezoko	354	13	group	group	NN
cord-316534-ep7ezoko	354	14	generated	generate	VBD
cord-316534-ep7ezoko	354	15	combinatorial	combinatorial	JJ
cord-316534-ep7ezoko	354	16	libraries	library	NNS
cord-316534-ep7ezoko	354	17	of	of	IN
cord-316534-ep7ezoko	354	18	HRV	HRV	NNP
cord-316534-ep7ezoko	354	19	capsid	capsid	RB
cord-316534-ep7ezoko	354	20	-	-	HYPH
cord-316534-ep7ezoko	354	21	incorporated	incorporate	VBN
cord-316534-ep7ezoko	354	22	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	354	23	gp41	gp41	NNP
cord-316534-ep7ezoko	354	24	epitope	epitope	NN
cord-316534-ep7ezoko	354	25	.	.	.
cord-316534-ep7ezoko	355	1	Their	-PRON-	PRP$
cord-316534-ep7ezoko	355	2	results	result	NNS
cord-316534-ep7ezoko	355	3	indicated	indicate	VBD
cord-316534-ep7ezoko	355	4	that	that	IN
cord-316534-ep7ezoko	355	5	they	-PRON-	PRP
cord-316534-ep7ezoko	355	6	were	be	VBD
cord-316534-ep7ezoko	355	7	successful	successful	JJ
cord-316534-ep7ezoko	355	8	in	in	IN
cord-316534-ep7ezoko	355	9	eliciting	elicit	VBG
cord-316534-ep7ezoko	355	10	antibodies	antibody	NNS
cord-316534-ep7ezoko	355	11	whose	whose	WP$
cord-316534-ep7ezoko	355	12	activity	activity	NN
cord-316534-ep7ezoko	355	13	can	can	MD
cord-316534-ep7ezoko	355	14	mimic	mimic	VB
cord-316534-ep7ezoko	355	15	the	the	DT
cord-316534-ep7ezoko	355	16	Nab	Nab	NNP
cord-316534-ep7ezoko	355	17	effect	effect	NN
cord-316534-ep7ezoko	355	18	.	.	.
cord-316534-ep7ezoko	356	1	149	149	CD
cord-316534-ep7ezoko	356	2	Commercial	commercial	JJ
cord-316534-ep7ezoko	356	3	and	and	CC
cord-316534-ep7ezoko	356	4	clinical	clinical	JJ
cord-316534-ep7ezoko	356	5	Ad	ad	NN
cord-316534-ep7ezoko	356	6	development	development	NN
cord-316534-ep7ezoko	356	7	of	of	IN
cord-316534-ep7ezoko	356	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	356	9	vaccines	vaccine	NNS
cord-316534-ep7ezoko	356	10	have	have	VBP
cord-316534-ep7ezoko	356	11	progressed	progress	VBN
cord-316534-ep7ezoko	356	12	preferentially	preferentially	RB
cord-316534-ep7ezoko	356	13	more	more	JJR
cord-316534-ep7ezoko	356	14	than	than	IN
cord-316534-ep7ezoko	356	15	vector	vector	NN
cord-316534-ep7ezoko	356	16	systems	system	NNS
cord-316534-ep7ezoko	356	17	such	such	JJ
cord-316534-ep7ezoko	356	18	as	as	IN
cord-316534-ep7ezoko	356	19	HRV	HRV	NNP
cord-316534-ep7ezoko	356	20	because	because	IN
cord-316534-ep7ezoko	356	21	the	the	DT
cord-316534-ep7ezoko	356	22	flexibility	flexibility	NN
cord-316534-ep7ezoko	356	23	of	of	IN
cord-316534-ep7ezoko	356	24	Ad	ad	NN
cord-316534-ep7ezoko	356	25	generally	generally	RB
cord-316534-ep7ezoko	356	26	exceeds	exceed	VBZ
cord-316534-ep7ezoko	356	27	current	current	JJ
cord-316534-ep7ezoko	356	28	rhinovirus	rhinovirus	NN
cord-316534-ep7ezoko	356	29	systems	system	NNS
cord-316534-ep7ezoko	356	30	.	.	.
cord-316534-ep7ezoko	357	1	For	for	IN
cord-316534-ep7ezoko	357	2	example	example	NN
cord-316534-ep7ezoko	357	3	,	,	,
cord-316534-ep7ezoko	357	4	because	because	IN
cord-316534-ep7ezoko	357	5	HRV	HRV	NNP
cord-316534-ep7ezoko	357	6	is	be	VBZ
cord-316534-ep7ezoko	357	7	a	a	DT
cord-316534-ep7ezoko	357	8	relatively	relatively	RB
cord-316534-ep7ezoko	357	9	small	small	JJ
cord-316534-ep7ezoko	357	10	RNA	RNA	NNP
cord-316534-ep7ezoko	357	11	virus	virus	NN
cord-316534-ep7ezoko	357	12	,	,	,
cord-316534-ep7ezoko	357	13	the	the	DT
cord-316534-ep7ezoko	357	14	HRV	HRV	NNP
cord-316534-ep7ezoko	357	15	platform	platform	NN
cord-316534-ep7ezoko	357	16	can	can	MD
cord-316534-ep7ezoko	357	17	display	display	VB
cord-316534-ep7ezoko	357	18	an	an	DT
cord-316534-ep7ezoko	357	19	array	array	NN
cord-316534-ep7ezoko	357	20	limited	limit	VBN
cord-316534-ep7ezoko	357	21	to	to	IN
cord-316534-ep7ezoko	357	22	60	60	CD
cord-316534-ep7ezoko	357	23	copies	copy	NNS
cord-316534-ep7ezoko	357	24	of	of	IN
cord-316534-ep7ezoko	357	25	a	a	DT
cord-316534-ep7ezoko	357	26	single	single	JJ
cord-316534-ep7ezoko	357	27	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	357	28	epitope	epitope	NN
cord-316534-ep7ezoko	357	29	.	.	.
cord-316534-ep7ezoko	358	1	148	148	CD
cord-316534-ep7ezoko	358	2	,	,	,
cord-316534-ep7ezoko	358	3	253	253	CD
cord-316534-ep7ezoko	359	1	In	in	IN
cord-316534-ep7ezoko	359	2	contrast	contrast	NN
cord-316534-ep7ezoko	359	3	,	,	,
cord-316534-ep7ezoko	359	4	the	the	DT
cord-316534-ep7ezoko	359	5	Ad	ad	NN
cord-316534-ep7ezoko	359	6	vector	vector	NN
cord-316534-ep7ezoko	359	7	platform	platform	NN
cord-316534-ep7ezoko	359	8	allows	allow	VBZ
cord-316534-ep7ezoko	359	9	incorporation	incorporation	NN
cord-316534-ep7ezoko	359	10	of	of	IN
cord-316534-ep7ezoko	359	11	the	the	DT
cord-316534-ep7ezoko	359	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	359	13	MPER	MPER	NNP
cord-316534-ep7ezoko	359	14	epitope	epitope	NN
cord-316534-ep7ezoko	359	15	into	into	IN
cord-316534-ep7ezoko	359	16	three	three	CD
cord-316534-ep7ezoko	359	17	structurally	structurally	RB
cord-316534-ep7ezoko	359	18	distinct	distinct	JJ
cord-316534-ep7ezoko	359	19	locales	locale	NNS
cord-316534-ep7ezoko	359	20	,	,	,
cord-316534-ep7ezoko	359	21	including	include	VBG
cord-316534-ep7ezoko	359	22	HVR2	HVR2	NNP
cord-316534-ep7ezoko	359	23	,	,	,
cord-316534-ep7ezoko	359	24	HVR5	HVR5	NNP
cord-316534-ep7ezoko	359	25	,	,	,
cord-316534-ep7ezoko	359	26	247	247	CD
cord-316534-ep7ezoko	359	27	and	and	CC
cord-316534-ep7ezoko	359	28	protein	protein	NN
cord-316534-ep7ezoko	359	29	IX	IX	NNP
cord-316534-ep7ezoko	359	30	(	(	-LRB-
cord-316534-ep7ezoko	359	31	our	-PRON-	PRP$
cord-316534-ep7ezoko	359	32	unpublished	unpublished	JJ
cord-316534-ep7ezoko	359	33	data	datum	NNS
cord-316534-ep7ezoko	359	34	)	)	-RRB-
cord-316534-ep7ezoko	359	35	.	.	.
cord-316534-ep7ezoko	360	1	In	in	IN
cord-316534-ep7ezoko	360	2	comparison	comparison	NN
cord-316534-ep7ezoko	360	3	,	,	,
cord-316534-ep7ezoko	360	4	the	the	DT
cord-316534-ep7ezoko	360	5	Ad	Ad	NNP
cord-316534-ep7ezoko	360	6	MPER	MPER	NNP
cord-316534-ep7ezoko	360	7	antigen	antigen	NN
cord-316534-ep7ezoko	360	8	capsid	capsid	NN
cord-316534-ep7ezoko	360	9	-	-	HYPH
cord-316534-ep7ezoko	360	10	incorporation	incorporation	NN
cord-316534-ep7ezoko	360	11	display	display	NN
cord-316534-ep7ezoko	360	12	platform	platform	NN
cord-316534-ep7ezoko	360	13	could	could	MD
cord-316534-ep7ezoko	360	14	present	present	VB
cord-316534-ep7ezoko	360	15	an	an	DT
cord-316534-ep7ezoko	360	16	array	array	NN
cord-316534-ep7ezoko	360	17	of	of	IN
cord-316534-ep7ezoko	360	18	720	720	CD
cord-316534-ep7ezoko	360	19	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	360	20	epitope	epitope	NN
cord-316534-ep7ezoko	360	21	copies	copy	NNS
cord-316534-ep7ezoko	360	22	within	within	IN
cord-316534-ep7ezoko	360	23	Ad	ad	NN
cord-316534-ep7ezoko	360	24	hexon	hexon	NN
cord-316534-ep7ezoko	360	25	and	and	CC
cord-316534-ep7ezoko	360	26	240	240	CD
cord-316534-ep7ezoko	360	27	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	360	28	epitope	epitope	NN
cord-316534-ep7ezoko	360	29	copies	copy	NNS
cord-316534-ep7ezoko	360	30	within	within	IN
cord-316534-ep7ezoko	360	31	pIX	pix	NN
cord-316534-ep7ezoko	360	32	.	.	.
cord-316534-ep7ezoko	361	1	If	if	IN
cord-316534-ep7ezoko	361	2	a	a	DT
cord-316534-ep7ezoko	361	3	multivalent	multivalent	JJ
cord-316534-ep7ezoko	361	4	Ad	ad	NN
cord-316534-ep7ezoko	361	5	vector	vector	NN
cord-316534-ep7ezoko	361	6	is	be	VBZ
cord-316534-ep7ezoko	361	7	generated	generate	VBN
cord-316534-ep7ezoko	361	8	with	with	IN
cord-316534-ep7ezoko	361	9	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	361	10	epitopes	epitope	NNS
cord-316534-ep7ezoko	361	11	within	within	IN
cord-316534-ep7ezoko	361	12	the	the	DT
cord-316534-ep7ezoko	361	13	hexon	hexon	NN
cord-316534-ep7ezoko	361	14	and	and	CC
cord-316534-ep7ezoko	361	15	the	the	DT
cord-316534-ep7ezoko	361	16	pIX	pix	NN
cord-316534-ep7ezoko	361	17	locales	locale	NNS
cord-316534-ep7ezoko	361	18	,	,	,
cord-316534-ep7ezoko	361	19	this	this	DT
cord-316534-ep7ezoko	361	20	would	would	MD
cord-316534-ep7ezoko	361	21	represent	represent	VB
cord-316534-ep7ezoko	361	22	960	960	CD
cord-316534-ep7ezoko	361	23	HIV	HIV	NNP
cord-316534-ep7ezoko	361	24	epitopes	epitope	NNS
cord-316534-ep7ezoko	361	25	within	within	IN
cord-316534-ep7ezoko	361	26	one	one	CD
cord-316534-ep7ezoko	361	27	Ad	ad	NN
cord-316534-ep7ezoko	361	28	vector	vector	NN
cord-316534-ep7ezoko	361	29	.	.	.
cord-316534-ep7ezoko	362	1	Another	another	DT
cord-316534-ep7ezoko	362	2	significant	significant	JJ
cord-316534-ep7ezoko	362	3	difference	difference	NN
cord-316534-ep7ezoko	362	4	between	between	IN
cord-316534-ep7ezoko	362	5	the	the	DT
cord-316534-ep7ezoko	362	6	Ad	Ad	NNP
cord-316534-ep7ezoko	362	7	and	and	CC
cord-316534-ep7ezoko	362	8	HRV	HRV	NNP
cord-316534-ep7ezoko	362	9	platforms	platform	NNS
cord-316534-ep7ezoko	362	10	is	be	VBZ
cord-316534-ep7ezoko	362	11	in	in	IN
cord-316534-ep7ezoko	362	12	the	the	DT
cord-316534-ep7ezoko	362	13	number	number	NN
cord-316534-ep7ezoko	362	14	of	of	IN
cord-316534-ep7ezoko	362	15	locales	locale	NNS
cord-316534-ep7ezoko	362	16	that	that	WDT
cord-316534-ep7ezoko	362	17	have	have	VBP
cord-316534-ep7ezoko	362	18	been	be	VBN
cord-316534-ep7ezoko	362	19	successfully	successfully	RB
cord-316534-ep7ezoko	362	20	used	use	VBN
cord-316534-ep7ezoko	362	21	for	for	IN
cord-316534-ep7ezoko	362	22	heterologous	heterologous	JJ
cord-316534-ep7ezoko	362	23	epitope	epitope	NN
cord-316534-ep7ezoko	362	24	insertion	insertion	NN
cord-316534-ep7ezoko	362	25	.	.	.
cord-316534-ep7ezoko	363	1	Finally	finally	RB
cord-316534-ep7ezoko	363	2	,	,	,
cord-316534-ep7ezoko	363	3	in	in	IN
cord-316534-ep7ezoko	363	4	contrast	contrast	NN
cord-316534-ep7ezoko	363	5	to	to	IN
cord-316534-ep7ezoko	363	6	the	the	DT
cord-316534-ep7ezoko	363	7	rhinovirus	rhinovirus	NN
cord-316534-ep7ezoko	363	8	that	that	WDT
cord-316534-ep7ezoko	363	9	lacks	lack	VBZ
cord-316534-ep7ezoko	363	10	this	this	DT
cord-316534-ep7ezoko	363	11	capacity	capacity	NN
cord-316534-ep7ezoko	363	12	,	,	,
cord-316534-ep7ezoko	363	13	the	the	DT
cord-316534-ep7ezoko	363	14	Ad	ad	NN
cord-316534-ep7ezoko	363	15	platform	platform	NN
cord-316534-ep7ezoko	363	16	has	have	VBZ
cord-316534-ep7ezoko	363	17	sufficient	sufficient	JJ
cord-316534-ep7ezoko	363	18	coding	coding	NN
cord-316534-ep7ezoko	363	19	capacity	capacity	NN
cord-316534-ep7ezoko	363	20	allowing	allow	VBG
cord-316534-ep7ezoko	363	21	for	for	IN
cord-316534-ep7ezoko	363	22	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	363	23	transgene	transgene	NN
cord-316534-ep7ezoko	363	24	expression	expression	NN
cord-316534-ep7ezoko	363	25	in	in	IN
cord-316534-ep7ezoko	363	26	combination	combination	NN
cord-316534-ep7ezoko	363	27	with	with	IN
cord-316534-ep7ezoko	363	28	presenting	present	VBG
cord-316534-ep7ezoko	363	29	the	the	DT
cord-316534-ep7ezoko	363	30	same	same	JJ
cord-316534-ep7ezoko	363	31	or	or	CC
cord-316534-ep7ezoko	363	32	a	a	DT
cord-316534-ep7ezoko	363	33	different	different	JJ
cord-316534-ep7ezoko	363	34	antigen	antigen	NN
cord-316534-ep7ezoko	363	35	on	on	IN
cord-316534-ep7ezoko	363	36	the	the	DT
cord-316534-ep7ezoko	363	37	viral	viral	JJ
cord-316534-ep7ezoko	363	38	capsid	capsid	NN
cord-316534-ep7ezoko	363	39	surface	surface	NN
cord-316534-ep7ezoko	363	40	.	.	.
cord-316534-ep7ezoko	364	1	This	this	DT
cord-316534-ep7ezoko	364	2	latter	latter	JJ
cord-316534-ep7ezoko	364	3	finding	finding	NN
cord-316534-ep7ezoko	364	4	is	be	VBZ
cord-316534-ep7ezoko	364	5	important	important	JJ
cord-316534-ep7ezoko	364	6	because	because	IN
cord-316534-ep7ezoko	364	7	it	-PRON-	PRP
cord-316534-ep7ezoko	364	8	provides	provide	VBZ
cord-316534-ep7ezoko	364	9	the	the	DT
cord-316534-ep7ezoko	364	10	basis	basis	NN
cord-316534-ep7ezoko	364	11	for	for	IN
cord-316534-ep7ezoko	364	12	constructing	construct	VBG
cord-316534-ep7ezoko	364	13	vectors	vector	NNS
cord-316534-ep7ezoko	364	14	that	that	WDT
cord-316534-ep7ezoko	364	15	will	will	MD
cord-316534-ep7ezoko	364	16	provide	provide	VB
cord-316534-ep7ezoko	364	17	cellular	cellular	JJ
cord-316534-ep7ezoko	364	18	and	and	CC
cord-316534-ep7ezoko	364	19	humoral	humoral	JJ
cord-316534-ep7ezoko	364	20	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	364	21	immunity	immunity	NN
cord-316534-ep7ezoko	364	22	.	.	.
cord-316534-ep7ezoko	365	1	Vectors	vector	NNS
cord-316534-ep7ezoko	365	2	which	which	WDT
cord-316534-ep7ezoko	365	3	provide	provide	VBP
cord-316534-ep7ezoko	365	4	both	both	DT
cord-316534-ep7ezoko	365	5	cellular	cellular	JJ
cord-316534-ep7ezoko	365	6	and	and	CC
cord-316534-ep7ezoko	365	7	humoral	humoral	JJ
cord-316534-ep7ezoko	365	8	immunity	immunity	NN
cord-316534-ep7ezoko	365	9	may	may	MD
cord-316534-ep7ezoko	365	10	be	be	VB
cord-316534-ep7ezoko	365	11	the	the	DT
cord-316534-ep7ezoko	365	12	way	way	NN
cord-316534-ep7ezoko	365	13	forward	forward	RB
cord-316534-ep7ezoko	365	14	with	with	IN
cord-316534-ep7ezoko	365	15	respect	respect	NN
cord-316534-ep7ezoko	365	16	to	to	IN
cord-316534-ep7ezoko	365	17	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	365	18	HIV	HIV	NNP
cord-316534-ep7ezoko	365	19	vaccine	vaccine	NN
cord-316534-ep7ezoko	365	20	development	development	NN
cord-316534-ep7ezoko	365	21	.	.	.
cord-316534-ep7ezoko	366	1	Recently	recently	RB
cord-316534-ep7ezoko	366	2	,	,	,
cord-316534-ep7ezoko	366	3	there	there	EX
cord-316534-ep7ezoko	366	4	have	have	VBP
cord-316534-ep7ezoko	366	5	been	be	VBN
cord-316534-ep7ezoko	366	6	encouraging	encourage	VBG
cord-316534-ep7ezoko	366	7	developments	development	NNS
cord-316534-ep7ezoko	366	8	regarding	regard	VBG
cord-316534-ep7ezoko	366	9	HIV	HIV	NNP
cord-316534-ep7ezoko	366	10	vaccination	vaccination	NN
cord-316534-ep7ezoko	366	11	.	.	.
cord-316534-ep7ezoko	367	1	In	in	IN
cord-316534-ep7ezoko	367	2	the	the	DT
cord-316534-ep7ezoko	367	3	1980s	1980	NNS
cord-316534-ep7ezoko	367	4	,	,	,
cord-316534-ep7ezoko	367	5	in	in	IN
cord-316534-ep7ezoko	367	6	Thailand	Thailand	NNP
cord-316534-ep7ezoko	367	7	,	,	,
cord-316534-ep7ezoko	367	8	there	there	EX
cord-316534-ep7ezoko	367	9	was	be	VBD
cord-316534-ep7ezoko	367	10	a	a	DT
cord-316534-ep7ezoko	367	11	substantial	substantial	JJ
cord-316534-ep7ezoko	367	12	increase	increase	NN
cord-316534-ep7ezoko	367	13	in	in	IN
cord-316534-ep7ezoko	367	14	the	the	DT
cord-316534-ep7ezoko	367	15	prevalence	prevalence	NN
cord-316534-ep7ezoko	367	16	of	of	IN
cord-316534-ep7ezoko	367	17	infection	infection	NN
cord-316534-ep7ezoko	367	18	with	with	IN
cord-316534-ep7ezoko	367	19	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	367	20	.	.	.
cord-316534-ep7ezoko	368	1	[	[	-LRB-
cord-316534-ep7ezoko	368	2	254	254	CD
cord-316534-ep7ezoko	368	3	]	]	-RRB-
cord-316534-ep7ezoko	368	4	[	[	-LRB-
cord-316534-ep7ezoko	368	5	255	255	CD
cord-316534-ep7ezoko	368	6	]	]	-RRB-
cord-316534-ep7ezoko	369	1	[	[	-LRB-
cord-316534-ep7ezoko	369	2	256	256	CD
cord-316534-ep7ezoko	369	3	]	]	-RRB-
cord-316534-ep7ezoko	370	1	By	by	IN
cord-316534-ep7ezoko	370	2	first	first	JJ
cord-316534-ep7ezoko	370	3	observation	observation	NN
cord-316534-ep7ezoko	370	4	,	,	,
cord-316534-ep7ezoko	370	5	these	these	DT
cord-316534-ep7ezoko	370	6	groups	group	NNS
cord-316534-ep7ezoko	370	7	consisted	consist	VBD
cord-316534-ep7ezoko	370	8	of	of	IN
cord-316534-ep7ezoko	370	9	intravenous	intravenous	JJ
cord-316534-ep7ezoko	370	10	-	-	HYPH
cord-316534-ep7ezoko	370	11	drug	drug	NN
cord-316534-ep7ezoko	370	12	users	user	NNS
cord-316534-ep7ezoko	370	13	and	and	CC
cord-316534-ep7ezoko	370	14	commercial	commercial	JJ
cord-316534-ep7ezoko	370	15	sex	sex	NN
cord-316534-ep7ezoko	370	16	workers	worker	NNS
cord-316534-ep7ezoko	370	17	;	;	:
cord-316534-ep7ezoko	370	18	this	this	DT
cord-316534-ep7ezoko	370	19	infected	infected	JJ
cord-316534-ep7ezoko	370	20	group	group	NN
cord-316534-ep7ezoko	370	21	then	then	RB
cord-316534-ep7ezoko	370	22	expanded	expand	VBD
cord-316534-ep7ezoko	370	23	to	to	IN
cord-316534-ep7ezoko	370	24	the	the	DT
cord-316534-ep7ezoko	370	25	general	general	JJ
cord-316534-ep7ezoko	370	26	population	population	NN
cord-316534-ep7ezoko	370	27	.	.	.
cord-316534-ep7ezoko	371	1	101	101	CD
cord-316534-ep7ezoko	372	1	By	by	IN
cord-316534-ep7ezoko	372	2	the	the	DT
cord-316534-ep7ezoko	372	3	mid	mid	JJ
cord-316534-ep7ezoko	372	4	1990s	1990	NNS
cord-316534-ep7ezoko	372	5	,	,	,
cord-316534-ep7ezoko	372	6	the	the	DT
cord-316534-ep7ezoko	372	7	overall	overall	JJ
cord-316534-ep7ezoko	372	8	seroprevalence	seroprevalence	NN
cord-316534-ep7ezoko	372	9	of	of	IN
cord-316534-ep7ezoko	372	10	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	372	11	reached	reach	VBD
cord-316534-ep7ezoko	372	12	a	a	DT
cord-316534-ep7ezoko	372	13	peak	peak	NN
cord-316534-ep7ezoko	372	14	of	of	IN
cord-316534-ep7ezoko	372	15	3.7	3.7	CD
cord-316534-ep7ezoko	372	16	%	%	NN
cord-316534-ep7ezoko	372	17	among	among	IN
cord-316534-ep7ezoko	372	18	members	member	NNS
cord-316534-ep7ezoko	372	19	of	of	IN
cord-316534-ep7ezoko	372	20	the	the	DT
cord-316534-ep7ezoko	372	21	Royal	Royal	NNP
cord-316534-ep7ezoko	372	22	Thai	Thai	NNP
cord-316534-ep7ezoko	372	23	Army	Army	NNP
cord-316534-ep7ezoko	372	24	and	and	CC
cord-316534-ep7ezoko	372	25	of	of	IN
cord-316534-ep7ezoko	372	26	12.5	12.5	CD
cord-316534-ep7ezoko	372	27	%	%	NN
cord-316534-ep7ezoko	372	28	among	among	IN
cord-316534-ep7ezoko	372	29	people	people	NNS
cord-316534-ep7ezoko	372	30	from	from	IN
cord-316534-ep7ezoko	372	31	Northern	Northern	NNP
cord-316534-ep7ezoko	372	32	Thailand	Thailand	NNP
cord-316534-ep7ezoko	372	33	.	.	.
cord-316534-ep7ezoko	373	1	255	255	CD
cord-316534-ep7ezoko	373	2	,	,	,
cord-316534-ep7ezoko	373	3	257	257	CD
cord-316534-ep7ezoko	374	1	The	the	DT
cord-316534-ep7ezoko	374	2	Thai	Thai	NNP
cord-316534-ep7ezoko	374	3	Ministry	Ministry	NNP
cord-316534-ep7ezoko	374	4	of	of	IN
cord-316534-ep7ezoko	374	5	Public	Public	NNP
cord-316534-ep7ezoko	374	6	Health	Health	NNP
cord-316534-ep7ezoko	374	7	acted	act	VBD
cord-316534-ep7ezoko	374	8	by	by	IN
cord-316534-ep7ezoko	374	9	starting	start	VBG
cord-316534-ep7ezoko	374	10	an	an	DT
cord-316534-ep7ezoko	374	11	effective	effective	JJ
cord-316534-ep7ezoko	374	12	HIV	HIV	NNP
cord-316534-ep7ezoko	374	13	-	-	HYPH
cord-316534-ep7ezoko	374	14	prevention	prevention	NN
cord-316534-ep7ezoko	374	15	campaign	campaign	NN
cord-316534-ep7ezoko	374	16	.	.	.
cord-316534-ep7ezoko	375	1	With	with	IN
cord-316534-ep7ezoko	375	2	this	this	DT
cord-316534-ep7ezoko	375	3	effort	effort	NN
cord-316534-ep7ezoko	375	4	,	,	,
cord-316534-ep7ezoko	375	5	the	the	DT
cord-316534-ep7ezoko	375	6	number	number	NN
cord-316534-ep7ezoko	375	7	of	of	IN
cord-316534-ep7ezoko	375	8	new	new	JJ
cord-316534-ep7ezoko	375	9	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	375	10	infections	infection	NNS
cord-316534-ep7ezoko	375	11	per	per	IN
cord-316534-ep7ezoko	375	12	year	year	NN
cord-316534-ep7ezoko	375	13	decreased	decrease	VBD
cord-316534-ep7ezoko	375	14	from	from	IN
cord-316534-ep7ezoko	375	15	an	an	DT
cord-316534-ep7ezoko	375	16	estimated	estimate	VBN
cord-316534-ep7ezoko	375	17	143,000	143,000	CD
cord-316534-ep7ezoko	375	18	in	in	IN
cord-316534-ep7ezoko	375	19	1990	1990	CD
cord-316534-ep7ezoko	375	20	to	to	IN
cord-316534-ep7ezoko	375	21	14,000	14,000	CD
cord-316534-ep7ezoko	375	22	in	in	IN
cord-316534-ep7ezoko	375	23	2007	2007	CD
cord-316534-ep7ezoko	375	24	.	.	.
cord-316534-ep7ezoko	376	1	255	255	CD
cord-316534-ep7ezoko	376	2	,	,	,
cord-316534-ep7ezoko	376	3	[	[	-LRB-
cord-316534-ep7ezoko	376	4	258	258	CD
cord-316534-ep7ezoko	376	5	]	]	-RRB-
cord-316534-ep7ezoko	376	6	[	[	-LRB-
cord-316534-ep7ezoko	376	7	259	259	CD
cord-316534-ep7ezoko	376	8	]	]	-RRB-
cord-316534-ep7ezoko	377	1	[	[	-LRB-
cord-316534-ep7ezoko	377	2	260	260	CD
cord-316534-ep7ezoko	377	3	]	]	-RRB-
cord-316534-ep7ezoko	378	1	Although	although	IN
cord-316534-ep7ezoko	378	2	this	this	DT
cord-316534-ep7ezoko	378	3	decrease	decrease	NN
cord-316534-ep7ezoko	378	4	was	be	VBD
cord-316534-ep7ezoko	378	5	promising	promising	JJ
cord-316534-ep7ezoko	378	6	,	,	,
cord-316534-ep7ezoko	378	7	there	there	EX
cord-316534-ep7ezoko	378	8	was	be	VBD
cord-316534-ep7ezoko	378	9	still	still	RB
cord-316534-ep7ezoko	378	10	a	a	DT
cord-316534-ep7ezoko	378	11	desire	desire	NN
cord-316534-ep7ezoko	378	12	to	to	TO
cord-316534-ep7ezoko	378	13	do	do	VB
cord-316534-ep7ezoko	378	14	more	more	JJR
cord-316534-ep7ezoko	378	15	to	to	TO
cord-316534-ep7ezoko	378	16	prevent	prevent	VB
cord-316534-ep7ezoko	378	17	HIV	HIV	NNP
cord-316534-ep7ezoko	378	18	infection	infection	NN
cord-316534-ep7ezoko	378	19	.	.	.
cord-316534-ep7ezoko	379	1	To	to	TO
cord-316534-ep7ezoko	379	2	achieve	achieve	VB
cord-316534-ep7ezoko	379	3	this	this	DT
cord-316534-ep7ezoko	379	4	goal	goal	NN
cord-316534-ep7ezoko	379	5	,	,	,
cord-316534-ep7ezoko	379	6	an	an	DT
cord-316534-ep7ezoko	379	7	HIV	HIV	NNP
cord-316534-ep7ezoko	379	8	Phase	Phase	NNP
cord-316534-ep7ezoko	379	9	III	III	NNP
cord-316534-ep7ezoko	379	10	study	study	NN
cord-316534-ep7ezoko	379	11	was	be	VBD
cord-316534-ep7ezoko	379	12	begun	begin	VBN
cord-316534-ep7ezoko	379	13	.	.	.
cord-316534-ep7ezoko	380	1	The	the	DT
cord-316534-ep7ezoko	380	2	Thai	Thai	NNP
cord-316534-ep7ezoko	380	3	Phase	Phase	NNP
cord-316534-ep7ezoko	380	4	III	iii	CD
cord-316534-ep7ezoko	380	5	HIV	HIV	NNP
cord-316534-ep7ezoko	380	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	380	7	study	study	NN
cord-316534-ep7ezoko	380	8	,	,	,
cord-316534-ep7ezoko	380	9	also	also	RB
cord-316534-ep7ezoko	380	10	known	know	VBN
cord-316534-ep7ezoko	380	11	as	as	IN
cord-316534-ep7ezoko	380	12	RV144	rv144	RB
cord-316534-ep7ezoko	380	13	,	,	,
cord-316534-ep7ezoko	380	14	opened	open	VBN
cord-316534-ep7ezoko	380	15	in	in	IN
cord-316534-ep7ezoko	380	16	the	the	DT
cord-316534-ep7ezoko	380	17	fall	fall	NN
cord-316534-ep7ezoko	380	18	of	of	IN
cord-316534-ep7ezoko	380	19	2003	2003	CD
cord-316534-ep7ezoko	380	20	.	.	.
cord-316534-ep7ezoko	381	1	The	the	DT
cord-316534-ep7ezoko	381	2	placebo	placebo	NN
cord-316534-ep7ezoko	381	3	-	-	HYPH
cord-316534-ep7ezoko	381	4	controlled	control	VBN
cord-316534-ep7ezoko	381	5	trial	trial	NN
cord-316534-ep7ezoko	381	6	tested	test	VBD
cord-316534-ep7ezoko	381	7	the	the	DT
cord-316534-ep7ezoko	381	8	safety	safety	NN
cord-316534-ep7ezoko	381	9	and	and	CC
cord-316534-ep7ezoko	381	10	effectiveness	effectiveness	NN
cord-316534-ep7ezoko	381	11	of	of	IN
cord-316534-ep7ezoko	381	12	a	a	DT
cord-316534-ep7ezoko	381	13	prime	prime	JJ
cord-316534-ep7ezoko	381	14	-	-	HYPH
cord-316534-ep7ezoko	381	15	boost	boost	NN
cord-316534-ep7ezoko	381	16	regimen	regimen	NN
cord-316534-ep7ezoko	381	17	of	of	IN
cord-316534-ep7ezoko	381	18	two	two	CD
cord-316534-ep7ezoko	381	19	vaccines	vaccine	NNS
cord-316534-ep7ezoko	381	20	:	:	:
cord-316534-ep7ezoko	381	21	ALVAC	ALVAC	NNP
cord-316534-ep7ezoko	381	22	-	-	HYPH
cord-316534-ep7ezoko	381	23	HIV	HIV	NNP
cord-316534-ep7ezoko	381	24	vaccine	vaccine	NN
cord-316534-ep7ezoko	381	25	(	(	-LRB-
cord-316534-ep7ezoko	381	26	the	the	DT
cord-316534-ep7ezoko	381	27	prime	prime	NN
cord-316534-ep7ezoko	381	28	)	)	-RRB-
cord-316534-ep7ezoko	381	29	,	,	,
cord-316534-ep7ezoko	381	30	a	a	DT
cord-316534-ep7ezoko	381	31	modified	modify	VBN
cord-316534-ep7ezoko	381	32	canarypox	canarypox	NN
cord-316534-ep7ezoko	381	33	vaccine	vaccine	NN
cord-316534-ep7ezoko	381	34	,	,	,
cord-316534-ep7ezoko	381	35	and	and	CC
cord-316534-ep7ezoko	381	36	AIDSVAX	AIDSVAX	NNP
cord-316534-ep7ezoko	381	37	B	B	NNP
cord-316534-ep7ezoko	381	38	/	/	SYM
cord-316534-ep7ezoko	381	39	E	e	NN
cord-316534-ep7ezoko	381	40	vaccine	vaccine	NN
cord-316534-ep7ezoko	381	41	(	(	-LRB-
cord-316534-ep7ezoko	381	42	booster	booster	NN
cord-316534-ep7ezoko	381	43	)	)	-RRB-
cord-316534-ep7ezoko	381	44	,	,	,
cord-316534-ep7ezoko	381	45	a	a	DT
cord-316534-ep7ezoko	381	46	gp	gp	NN
cord-316534-ep7ezoko	381	47	120	120	CD
cord-316534-ep7ezoko	381	48	vaccine	vaccine	NN
cord-316534-ep7ezoko	381	49	.	.	.
cord-316534-ep7ezoko	382	1	The	the	DT
cord-316534-ep7ezoko	382	2	vaccines	vaccine	NNS
cord-316534-ep7ezoko	382	3	were	be	VBD
cord-316534-ep7ezoko	382	4	based	base	VBN
cord-316534-ep7ezoko	382	5	on	on	IN
cord-316534-ep7ezoko	382	6	the	the	DT
cord-316534-ep7ezoko	382	7	subtype	subtype	NN
cord-316534-ep7ezoko	382	8	E	e	NN
cord-316534-ep7ezoko	382	9	and	and	CC
cord-316534-ep7ezoko	382	10	B	B	NNP
cord-316534-ep7ezoko	382	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	382	12	strains	strain	NNS
cord-316534-ep7ezoko	382	13	that	that	WDT
cord-316534-ep7ezoko	382	14	commonly	commonly	RB
cord-316534-ep7ezoko	382	15	circulate	circulate	VBP
cord-316534-ep7ezoko	382	16	in	in	IN
cord-316534-ep7ezoko	382	17	Thailand	Thailand	NNP
cord-316534-ep7ezoko	382	18	.	.	.
cord-316534-ep7ezoko	383	1	The	the	DT
cord-316534-ep7ezoko	383	2	subtype	subtype	NN
cord-316534-ep7ezoko	383	3	B	B	NNP
cord-316534-ep7ezoko	383	4	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	383	5	strain	strain	NN
cord-316534-ep7ezoko	383	6	is	be	VBZ
cord-316534-ep7ezoko	383	7	the	the	DT
cord-316534-ep7ezoko	383	8	most	most	RBS
cord-316534-ep7ezoko	383	9	commonly	commonly	RB
cord-316534-ep7ezoko	383	10	found	find	VBD
cord-316534-ep7ezoko	383	11	strain	strain	NN
cord-316534-ep7ezoko	383	12	in	in	IN
cord-316534-ep7ezoko	383	13	the	the	DT
cord-316534-ep7ezoko	383	14	United	United	NNP
cord-316534-ep7ezoko	383	15	States	States	NNP
cord-316534-ep7ezoko	383	16	.	.	.
cord-316534-ep7ezoko	384	1	The	the	DT
cord-316534-ep7ezoko	384	2	trial	trial	NN
cord-316534-ep7ezoko	384	3	,	,	,
cord-316534-ep7ezoko	384	4	conducted	conduct	VBN
cord-316534-ep7ezoko	384	5	in	in	IN
cord-316534-ep7ezoko	384	6	the	the	DT
cord-316534-ep7ezoko	384	7	Chonburi	Chonburi	NNP
cord-316534-ep7ezoko	384	8	and	and	CC
cord-316534-ep7ezoko	384	9	Rayong	Rayong	NNP
cord-316534-ep7ezoko	384	10	provinces	province	NNS
cord-316534-ep7ezoko	384	11	of	of	IN
cord-316534-ep7ezoko	384	12	Thailand	Thailand	NNP
cord-316534-ep7ezoko	384	13	,	,	,
cord-316534-ep7ezoko	384	14	enrolled	enrol	VBD
cord-316534-ep7ezoko	384	15	16,402	16,402	CD
cord-316534-ep7ezoko	384	16	women	woman	NNS
cord-316534-ep7ezoko	384	17	and	and	CC
cord-316534-ep7ezoko	384	18	men	man	NNS
cord-316534-ep7ezoko	384	19	aged	age	VBN
cord-316534-ep7ezoko	384	20	18	18	CD
cord-316534-ep7ezoko	384	21	-	-	SYM
cord-316534-ep7ezoko	384	22	30	30	CD
cord-316534-ep7ezoko	384	23	years	year	NNS
cord-316534-ep7ezoko	384	24	at	at	IN
cord-316534-ep7ezoko	384	25	various	various	JJ
cord-316534-ep7ezoko	384	26	levels	level	NNS
cord-316534-ep7ezoko	384	27	of	of	IN
cord-316534-ep7ezoko	384	28	risk	risk	NN
cord-316534-ep7ezoko	384	29	for	for	IN
cord-316534-ep7ezoko	384	30	HIV	HIV	NNP
cord-316534-ep7ezoko	384	31	infection	infection	NN
cord-316534-ep7ezoko	384	32	.	.	.
cord-316534-ep7ezoko	385	1	Study	study	NN
cord-316534-ep7ezoko	385	2	participants	participant	NNS
cord-316534-ep7ezoko	385	3	received	receive	VBD
cord-316534-ep7ezoko	385	4	the	the	DT
cord-316534-ep7ezoko	385	5	placebo	placebo	NN
cord-316534-ep7ezoko	385	6	or	or	CC
cord-316534-ep7ezoko	385	7	ALVAC	ALVAC	NNP
cord-316534-ep7ezoko	385	8	HIV	HIV	NNP
cord-316534-ep7ezoko	385	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	385	10	at	at	IN
cord-316534-ep7ezoko	385	11	enrollment	enrollment	NN
cord-316534-ep7ezoko	385	12	and	and	CC
cord-316534-ep7ezoko	385	13	again	again	RB
cord-316534-ep7ezoko	385	14	after	after	IN
cord-316534-ep7ezoko	385	15	1	1	CD
cord-316534-ep7ezoko	385	16	,	,	,
cord-316534-ep7ezoko	385	17	3	3	CD
cord-316534-ep7ezoko	385	18	,	,	,
cord-316534-ep7ezoko	385	19	Prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	385	20	vaccine	vaccine	NN
cord-316534-ep7ezoko	385	21	for	for	IN
cord-316534-ep7ezoko	385	22	Hiv-1	Hiv-1	NNP
cord-316534-ep7ezoko	385	23	and	and	CC
cord-316534-ep7ezoko	385	24	6	6	CD
cord-316534-ep7ezoko	385	25	months	month	NNS
cord-316534-ep7ezoko	385	26	.	.	.
cord-316534-ep7ezoko	386	1	The	the	DT
cord-316534-ep7ezoko	386	2	placebo	placebo	NN
cord-316534-ep7ezoko	386	3	or	or	CC
cord-316534-ep7ezoko	386	4	AIDSVAX	AIDSVAX	NNP
cord-316534-ep7ezoko	386	5	B	B	NNP
cord-316534-ep7ezoko	386	6	/	/	SYM
cord-316534-ep7ezoko	386	7	E	e	NN
cord-316534-ep7ezoko	386	8	vaccine	vaccine	NN
cord-316534-ep7ezoko	386	9	was	be	VBD
cord-316534-ep7ezoko	386	10	given	give	VBN
cord-316534-ep7ezoko	386	11	to	to	IN
cord-316534-ep7ezoko	386	12	participants	participant	NNS
cord-316534-ep7ezoko	386	13	at	at	IN
cord-316534-ep7ezoko	386	14	3	3	CD
cord-316534-ep7ezoko	386	15	and	and	CC
cord-316534-ep7ezoko	386	16	6	6	CD
cord-316534-ep7ezoko	386	17	months	month	NNS
cord-316534-ep7ezoko	386	18	.	.	.
cord-316534-ep7ezoko	387	1	Participants	participant	NNS
cord-316534-ep7ezoko	387	2	were	be	VBD
cord-316534-ep7ezoko	387	3	tested	test	VBN
cord-316534-ep7ezoko	387	4	for	for	IN
cord-316534-ep7ezoko	387	5	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	387	6	infection	infection	NN
cord-316534-ep7ezoko	387	7	every	every	DT
cord-316534-ep7ezoko	387	8	6	6	CD
cord-316534-ep7ezoko	387	9	months	month	NNS
cord-316534-ep7ezoko	387	10	for	for	IN
cord-316534-ep7ezoko	387	11	3	3	CD
cord-316534-ep7ezoko	387	12	years	year	NNS
cord-316534-ep7ezoko	387	13	.	.	.
cord-316534-ep7ezoko	388	1	During	during	IN
cord-316534-ep7ezoko	388	2	each	each	DT
cord-316534-ep7ezoko	388	3	clinic	clinic	NN
cord-316534-ep7ezoko	388	4	visit	visit	NN
cord-316534-ep7ezoko	388	5	,	,	,
cord-316534-ep7ezoko	388	6	study	study	NN
cord-316534-ep7ezoko	388	7	participants	participant	NNS
cord-316534-ep7ezoko	388	8	were	be	VBD
cord-316534-ep7ezoko	388	9	counseled	counsel	VBN
cord-316534-ep7ezoko	388	10	on	on	IN
cord-316534-ep7ezoko	388	11	how	how	WRB
cord-316534-ep7ezoko	388	12	to	to	TO
cord-316534-ep7ezoko	388	13	prevent	prevent	VB
cord-316534-ep7ezoko	388	14	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	388	15	infection	infection	NN
cord-316534-ep7ezoko	388	16	.	.	.
cord-316534-ep7ezoko	389	1	The	the	DT
cord-316534-ep7ezoko	389	2	results	result	NNS
cord-316534-ep7ezoko	389	3	showed	show	VBD
cord-316534-ep7ezoko	389	4	that	that	IN
cord-316534-ep7ezoko	389	5	74	74	CD
cord-316534-ep7ezoko	389	6	of	of	IN
cord-316534-ep7ezoko	389	7	8198	8198	CD
cord-316534-ep7ezoko	389	8	placebo	placebo	NN
cord-316534-ep7ezoko	389	9	recipients	recipient	NNS
cord-316534-ep7ezoko	389	10	became	become	VBD
cord-316534-ep7ezoko	389	11	infected	infect	VBN
cord-316534-ep7ezoko	389	12	with	with	IN
cord-316534-ep7ezoko	389	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	389	14	compared	compare	VBN
cord-316534-ep7ezoko	389	15	with	with	IN
cord-316534-ep7ezoko	389	16	51	51	CD
cord-316534-ep7ezoko	389	17	of	of	IN
cord-316534-ep7ezoko	389	18	8197	8197	CD
cord-316534-ep7ezoko	389	19	participants	participant	NNS
cord-316534-ep7ezoko	389	20	who	who	WP
cord-316534-ep7ezoko	389	21	received	receive	VBD
cord-316534-ep7ezoko	389	22	the	the	DT
cord-316534-ep7ezoko	389	23	vaccine	vaccine	NN
cord-316534-ep7ezoko	389	24	.	.	.
cord-316534-ep7ezoko	390	1	This	this	DT
cord-316534-ep7ezoko	390	2	level	level	NN
cord-316534-ep7ezoko	390	3	of	of	IN
cord-316534-ep7ezoko	390	4	effectiveness	effectiveness	NN
cord-316534-ep7ezoko	390	5	in	in	IN
cord-316534-ep7ezoko	390	6	preventing	prevent	VBG
cord-316534-ep7ezoko	390	7	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	390	8	infection	infection	NN
cord-316534-ep7ezoko	390	9	was	be	VBD
cord-316534-ep7ezoko	390	10	found	find	VBN
cord-316534-ep7ezoko	390	11	to	to	TO
cord-316534-ep7ezoko	390	12	be	be	VB
cord-316534-ep7ezoko	390	13	statistically	statistically	RB
cord-316534-ep7ezoko	390	14	significant	significant	JJ
cord-316534-ep7ezoko	390	15	.	.	.
cord-316534-ep7ezoko	391	1	The	the	DT
cord-316534-ep7ezoko	391	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	391	3	strategy	strategy	NN
cord-316534-ep7ezoko	391	4	had	have	VBD
cord-316534-ep7ezoko	391	5	no	no	DT
cord-316534-ep7ezoko	391	6	effect	effect	NN
cord-316534-ep7ezoko	391	7	,	,	,
cord-316534-ep7ezoko	391	8	however	however	RB
cord-316534-ep7ezoko	391	9	,	,	,
cord-316534-ep7ezoko	391	10	on	on	IN
cord-316534-ep7ezoko	391	11	the	the	DT
cord-316534-ep7ezoko	391	12	amount	amount	NN
cord-316534-ep7ezoko	391	13	of	of	IN
cord-316534-ep7ezoko	391	14	virus	virus	NN
cord-316534-ep7ezoko	391	15	in	in	IN
cord-316534-ep7ezoko	391	16	the	the	DT
cord-316534-ep7ezoko	391	17	blood	blood	NN
cord-316534-ep7ezoko	391	18	of	of	IN
cord-316534-ep7ezoko	391	19	volunteers	volunteer	NNS
cord-316534-ep7ezoko	391	20	who	who	WP
cord-316534-ep7ezoko	391	21	acquired	acquire	VBD
cord-316534-ep7ezoko	391	22	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	391	23	infection	infection	NN
cord-316534-ep7ezoko	391	24	during	during	IN
cord-316534-ep7ezoko	391	25	the	the	DT
cord-316534-ep7ezoko	391	26	study	study	NN
cord-316534-ep7ezoko	391	27	.	.	.
cord-316534-ep7ezoko	392	1	Based	base	VBN
cord-316534-ep7ezoko	392	2	on	on	IN
cord-316534-ep7ezoko	392	3	the	the	DT
cord-316534-ep7ezoko	392	4	final	final	JJ
cord-316534-ep7ezoko	392	5	analysis	analysis	NN
cord-316534-ep7ezoko	392	6	of	of	IN
cord-316534-ep7ezoko	392	7	the	the	DT
cord-316534-ep7ezoko	392	8	study	study	NN
cord-316534-ep7ezoko	392	9	,	,	,
cord-316534-ep7ezoko	392	10	the	the	DT
cord-316534-ep7ezoko	392	11	surgeon	surgeon	NN
cord-316534-ep7ezoko	392	12	general	general	JJ
cord-316534-ep7ezoko	392	13	of	of	IN
cord-316534-ep7ezoko	392	14	the	the	DT
cord-316534-ep7ezoko	392	15	US	US	NNP
cord-316534-ep7ezoko	392	16	Army	Army	NNP
cord-316534-ep7ezoko	392	17	,	,	,
cord-316534-ep7ezoko	392	18	the	the	DT
cord-316534-ep7ezoko	392	19	trial	trial	NN
cord-316534-ep7ezoko	392	20	sponsor	sponsor	NN
cord-316534-ep7ezoko	392	21	,	,	,
cord-316534-ep7ezoko	392	22	announced	announce	VBD
cord-316534-ep7ezoko	392	23	that	that	IN
cord-316534-ep7ezoko	392	24	the	the	DT
cord-316534-ep7ezoko	392	25	prime	prime	JJ
cord-316534-ep7ezoko	392	26	-	-	HYPH
cord-316534-ep7ezoko	392	27	boost	boost	JJ
cord-316534-ep7ezoko	392	28	investigational	investigational	JJ
cord-316534-ep7ezoko	392	29	vaccine	vaccine	NN
cord-316534-ep7ezoko	392	30	regimen	regimen	NN
cord-316534-ep7ezoko	392	31	was	be	VBD
cord-316534-ep7ezoko	392	32	safe	safe	JJ
cord-316534-ep7ezoko	392	33	and	and	CC
cord-316534-ep7ezoko	392	34	31	31	CD
cord-316534-ep7ezoko	392	35	%	%	NN
cord-316534-ep7ezoko	392	36	effective	effective	JJ
cord-316534-ep7ezoko	392	37	in	in	IN
cord-316534-ep7ezoko	392	38	preventing	prevent	VBG
cord-316534-ep7ezoko	392	39	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	392	40	infection	infection	NN
cord-316534-ep7ezoko	392	41	.	.	.
cord-316534-ep7ezoko	393	1	With	with	IN
cord-316534-ep7ezoko	393	2	respect	respect	NN
cord-316534-ep7ezoko	393	3	to	to	IN
cord-316534-ep7ezoko	393	4	an	an	DT
cord-316534-ep7ezoko	393	5	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	393	6	vaccine	vaccine	NN
cord-316534-ep7ezoko	393	7	that	that	WDT
cord-316534-ep7ezoko	393	8	can	can	MD
cord-316534-ep7ezoko	393	9	provide	provide	VB
cord-316534-ep7ezoko	393	10	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	393	11	HIV	HIV	NNP
cord-316534-ep7ezoko	393	12	immunity	immunity	NN
cord-316534-ep7ezoko	393	13	,	,	,
cord-316534-ep7ezoko	393	14	this	this	DT
cord-316534-ep7ezoko	393	15	is	be	VBZ
cord-316534-ep7ezoko	393	16	the	the	DT
cord-316534-ep7ezoko	393	17	best	good	JJS
cord-316534-ep7ezoko	393	18	result	result	NN
cord-316534-ep7ezoko	393	19	in	in	IN
cord-316534-ep7ezoko	393	20	humans	human	NNS
cord-316534-ep7ezoko	393	21	to	to	IN
cord-316534-ep7ezoko	393	22	date	date	NN
cord-316534-ep7ezoko	393	23	.	.	.
cord-316534-ep7ezoko	394	1	However	however	RB
cord-316534-ep7ezoko	394	2	,	,	,
cord-316534-ep7ezoko	394	3	the	the	DT
cord-316534-ep7ezoko	394	4	modest	modest	JJ
cord-316534-ep7ezoko	394	5	protection	protection	NN
cord-316534-ep7ezoko	394	6	effect	effect	NN
cord-316534-ep7ezoko	394	7	appeared	appear	VBD
cord-316534-ep7ezoko	394	8	limited	limited	JJ
cord-316534-ep7ezoko	394	9	to	to	IN
cord-316534-ep7ezoko	394	10	low	low	JJ
cord-316534-ep7ezoko	394	11	-	-	HYPH
cord-316534-ep7ezoko	394	12	risk	risk	NN
cord-316534-ep7ezoko	394	13	individuals	individual	NNS
cord-316534-ep7ezoko	394	14	,	,	,
cord-316534-ep7ezoko	394	15	and	and	CC
cord-316534-ep7ezoko	394	16	there	there	EX
cord-316534-ep7ezoko	394	17	were	be	VBD
cord-316534-ep7ezoko	394	18	data	datum	NNS
cord-316534-ep7ezoko	394	19	which	which	WDT
cord-316534-ep7ezoko	394	20	suggest	suggest	VBP
cord-316534-ep7ezoko	394	21	that	that	IN
cord-316534-ep7ezoko	394	22	this	this	DT
cord-316534-ep7ezoko	394	23	effect	effect	NN
cord-316534-ep7ezoko	394	24	was	be	VBD
cord-316534-ep7ezoko	394	25	confined	confine	VBN
cord-316534-ep7ezoko	394	26	to	to	IN
cord-316534-ep7ezoko	394	27	the	the	DT
cord-316534-ep7ezoko	394	28	first	first	JJ
cord-316534-ep7ezoko	394	29	year	year	NN
cord-316534-ep7ezoko	394	30	following	follow	VBG
cord-316534-ep7ezoko	394	31	administration	administration	NN
cord-316534-ep7ezoko	394	32	of	of	IN
cord-316534-ep7ezoko	394	33	the	the	DT
cord-316534-ep7ezoko	394	34	vaccine	vaccine	NN
cord-316534-ep7ezoko	394	35	.	.	.
cord-316534-ep7ezoko	395	1	Efforts	effort	NNS
cord-316534-ep7ezoko	395	2	must	must	MD
cord-316534-ep7ezoko	395	3	continue	continue	VB
cord-316534-ep7ezoko	395	4	to	to	TO
cord-316534-ep7ezoko	395	5	focus	focus	VB
cord-316534-ep7ezoko	395	6	on	on	IN
cord-316534-ep7ezoko	395	7	evaluating	evaluate	VBG
cord-316534-ep7ezoko	395	8	the	the	DT
cord-316534-ep7ezoko	395	9	immune	immune	JJ
cord-316534-ep7ezoko	395	10	response	response	NN
cord-316534-ep7ezoko	395	11	induced	induce	VBN
cord-316534-ep7ezoko	395	12	by	by	IN
cord-316534-ep7ezoko	395	13	the	the	DT
cord-316534-ep7ezoko	395	14	vaccine	vaccine	NN
cord-316534-ep7ezoko	395	15	to	to	TO
cord-316534-ep7ezoko	395	16	establish	establish	VB
cord-316534-ep7ezoko	395	17	potential	potential	JJ
cord-316534-ep7ezoko	395	18	correlates	correlate	NNS
cord-316534-ep7ezoko	395	19	of	of	IN
cord-316534-ep7ezoko	395	20	protection	protection	NN
cord-316534-ep7ezoko	395	21	.	.	.
cord-316534-ep7ezoko	396	1	Over	over	IN
cord-316534-ep7ezoko	396	2	the	the	DT
cord-316534-ep7ezoko	396	3	last	last	JJ
cord-316534-ep7ezoko	396	4	three	three	CD
cord-316534-ep7ezoko	396	5	decades	decade	NNS
cord-316534-ep7ezoko	396	6	,	,	,
cord-316534-ep7ezoko	396	7	the	the	DT
cord-316534-ep7ezoko	396	8	world	world	NN
cord-316534-ep7ezoko	396	9	has	have	VBZ
cord-316534-ep7ezoko	396	10	been	be	VBN
cord-316534-ep7ezoko	396	11	faced	face	VBN
cord-316534-ep7ezoko	396	12	with	with	IN
cord-316534-ep7ezoko	396	13	the	the	DT
cord-316534-ep7ezoko	396	14	emergence	emergence	NN
cord-316534-ep7ezoko	396	15	and	and	CC
cord-316534-ep7ezoko	396	16	subsequent	subsequent	JJ
cord-316534-ep7ezoko	396	17	epidemic	epidemic	NN
cord-316534-ep7ezoko	396	18	of	of	IN
cord-316534-ep7ezoko	396	19	HIV	HIV	NNP
cord-316534-ep7ezoko	396	20	/	/	SYM
cord-316534-ep7ezoko	396	21	AIDS	AIDS	NNP
cord-316534-ep7ezoko	396	22	.	.	.
cord-316534-ep7ezoko	397	1	There	there	EX
cord-316534-ep7ezoko	397	2	has	have	VBZ
cord-316534-ep7ezoko	397	3	been	be	VBN
cord-316534-ep7ezoko	397	4	much	much	JJ
cord-316534-ep7ezoko	397	5	progress	progress	NN
cord-316534-ep7ezoko	397	6	with	with	IN
cord-316534-ep7ezoko	397	7	respect	respect	NN
cord-316534-ep7ezoko	397	8	to	to	IN
cord-316534-ep7ezoko	397	9	diagnosis	diagnosis	NN
cord-316534-ep7ezoko	397	10	and	and	CC
cord-316534-ep7ezoko	397	11	prevention	prevention	NN
cord-316534-ep7ezoko	397	12	.	.	.
cord-316534-ep7ezoko	398	1	On	on	IN
cord-316534-ep7ezoko	398	2	the	the	DT
cord-316534-ep7ezoko	398	3	treatment	treatment	NN
cord-316534-ep7ezoko	398	4	front	front	NN
cord-316534-ep7ezoko	398	5	,	,	,
cord-316534-ep7ezoko	398	6	there	there	EX
cord-316534-ep7ezoko	398	7	have	have	VBP
cord-316534-ep7ezoko	398	8	been	be	VBN
cord-316534-ep7ezoko	398	9	several	several	JJ
cord-316534-ep7ezoko	398	10	significant	significant	JJ
cord-316534-ep7ezoko	398	11	advances	advance	NNS
cord-316534-ep7ezoko	398	12	with	with	IN
cord-316534-ep7ezoko	398	13	respect	respect	NN
cord-316534-ep7ezoko	398	14	to	to	IN
cord-316534-ep7ezoko	398	15	drug	drug	NN
cord-316534-ep7ezoko	398	16	development	development	NN
cord-316534-ep7ezoko	398	17	(	(	-LRB-
cord-316534-ep7ezoko	398	18	ie	ie	FW
cord-316534-ep7ezoko	398	19	,	,	,
cord-316534-ep7ezoko	398	20	ART	ART	NNP
cord-316534-ep7ezoko	398	21	/	/	SYM
cord-316534-ep7ezoko	398	22	HAART	HAART	NNP
cord-316534-ep7ezoko	398	23	)	)	-RRB-
cord-316534-ep7ezoko	398	24	.	.	.
cord-316534-ep7ezoko	399	1	However	however	RB
cord-316534-ep7ezoko	399	2	,	,	,
cord-316534-ep7ezoko	399	3	there	there	EX
cord-316534-ep7ezoko	399	4	is	be	VBZ
cord-316534-ep7ezoko	399	5	a	a	DT
cord-316534-ep7ezoko	399	6	desperate	desperate	JJ
cord-316534-ep7ezoko	399	7	need	need	NN
cord-316534-ep7ezoko	399	8	for	for	IN
cord-316534-ep7ezoko	399	9	an	an	DT
cord-316534-ep7ezoko	399	10	effective	effective	JJ
cord-316534-ep7ezoko	399	11	and	and	CC
cord-316534-ep7ezoko	399	12	safe	safe	JJ
cord-316534-ep7ezoko	399	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	399	14	.	.	.
cord-316534-ep7ezoko	400	1	There	there	EX
cord-316534-ep7ezoko	400	2	has	have	VBZ
cord-316534-ep7ezoko	400	3	been	be	VBN
cord-316534-ep7ezoko	400	4	tremendous	tremendous	JJ
cord-316534-ep7ezoko	400	5	difficulty	difficulty	NN
cord-316534-ep7ezoko	400	6	with	with	IN
cord-316534-ep7ezoko	400	7	regard	regard	NN
cord-316534-ep7ezoko	400	8	to	to	IN
cord-316534-ep7ezoko	400	9	developing	develop	VBG
cord-316534-ep7ezoko	400	10	a	a	DT
cord-316534-ep7ezoko	400	11	vaccine	vaccine	NN
cord-316534-ep7ezoko	400	12	that	that	WDT
cord-316534-ep7ezoko	400	13	provides	provide	VBZ
cord-316534-ep7ezoko	400	14	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	400	15	immunity	immunity	NN
cord-316534-ep7ezoko	400	16	.	.	.
cord-316534-ep7ezoko	401	1	This	this	DT
cord-316534-ep7ezoko	401	2	has	have	VBZ
cord-316534-ep7ezoko	401	3	been	be	VBN
cord-316534-ep7ezoko	401	4	the	the	DT
cord-316534-ep7ezoko	401	5	case	case	NN
cord-316534-ep7ezoko	401	6	due	due	IN
cord-316534-ep7ezoko	401	7	to	to	IN
cord-316534-ep7ezoko	401	8	some	some	DT
cord-316534-ep7ezoko	401	9	of	of	IN
cord-316534-ep7ezoko	401	10	the	the	DT
cord-316534-ep7ezoko	401	11	factors	factor	NNS
cord-316534-ep7ezoko	401	12	mentioned	mention	VBN
cord-316534-ep7ezoko	401	13	in	in	IN
cord-316534-ep7ezoko	401	14	this	this	DT
cord-316534-ep7ezoko	401	15	review	review	NN
cord-316534-ep7ezoko	401	16	such	such	JJ
cord-316534-ep7ezoko	401	17	as	as	IN
cord-316534-ep7ezoko	401	18	HIV	HIV	NNP
cord-316534-ep7ezoko	401	19	diversity	diversity	NN
cord-316534-ep7ezoko	401	20	,	,	,
cord-316534-ep7ezoko	401	21	immune	immune	JJ
cord-316534-ep7ezoko	401	22	evasion	evasion	NN
cord-316534-ep7ezoko	401	23	,	,	,
cord-316534-ep7ezoko	401	24	and	and	CC
cord-316534-ep7ezoko	401	25	lack	lack	NN
cord-316534-ep7ezoko	401	26	of	of	IN
cord-316534-ep7ezoko	401	27	appropriate	appropriate	JJ
cord-316534-ep7ezoko	401	28	animal	animal	NN
cord-316534-ep7ezoko	401	29	models	model	NNS
cord-316534-ep7ezoko	401	30	.	.	.
cord-316534-ep7ezoko	402	1	Due	due	IN
cord-316534-ep7ezoko	402	2	to	to	IN
cord-316534-ep7ezoko	402	3	these	these	DT
cord-316534-ep7ezoko	402	4	obstacles	obstacle	NNS
cord-316534-ep7ezoko	402	5	,	,	,
cord-316534-ep7ezoko	402	6	many	many	JJ
cord-316534-ep7ezoko	402	7	researchers	researcher	NNS
cord-316534-ep7ezoko	402	8	assumed	assume	VBD
cord-316534-ep7ezoko	402	9	that	that	IN
cord-316534-ep7ezoko	402	10	the	the	DT
cord-316534-ep7ezoko	402	11	control	control	NN
cord-316534-ep7ezoko	402	12	of	of	IN
cord-316534-ep7ezoko	402	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	402	14	viremia	viremia	NN
cord-316534-ep7ezoko	402	15	by	by	IN
cord-316534-ep7ezoko	402	16	vaccination	vaccination	NN
cord-316534-ep7ezoko	402	17	would	would	MD
cord-316534-ep7ezoko	402	18	be	be	VB
cord-316534-ep7ezoko	402	19	a	a	DT
cord-316534-ep7ezoko	402	20	more	more	RBR
cord-316534-ep7ezoko	402	21	realistic	realistic	JJ
cord-316534-ep7ezoko	402	22	goal	goal	NN
cord-316534-ep7ezoko	402	23	than	than	IN
cord-316534-ep7ezoko	402	24	the	the	DT
cord-316534-ep7ezoko	402	25	development	development	NN
cord-316534-ep7ezoko	402	26	of	of	IN
cord-316534-ep7ezoko	402	27	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	402	28	immunity	immunity	NN
cord-316534-ep7ezoko	402	29	.	.	.
cord-316534-ep7ezoko	403	1	The	the	DT
cord-316534-ep7ezoko	403	2	road	road	NN
cord-316534-ep7ezoko	403	3	to	to	IN
cord-316534-ep7ezoko	403	4	a	a	DT
cord-316534-ep7ezoko	403	5	safe	safe	JJ
cord-316534-ep7ezoko	403	6	and	and	CC
cord-316534-ep7ezoko	403	7	effective	effective	JJ
cord-316534-ep7ezoko	403	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	403	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	403	10	received	receive	VBD
cord-316534-ep7ezoko	403	11	a	a	DT
cord-316534-ep7ezoko	403	12	serious	serious	JJ
cord-316534-ep7ezoko	403	13	setback	setback	NN
cord-316534-ep7ezoko	403	14	in	in	IN
cord-316534-ep7ezoko	403	15	the	the	DT
cord-316534-ep7ezoko	403	16	fall	fall	NN
cord-316534-ep7ezoko	403	17	of	of	IN
cord-316534-ep7ezoko	403	18	2007	2007	CD
cord-316534-ep7ezoko	403	19	with	with	IN
cord-316534-ep7ezoko	403	20	the	the	DT
cord-316534-ep7ezoko	403	21	premature	premature	JJ
cord-316534-ep7ezoko	403	22	termination	termination	NN
cord-316534-ep7ezoko	403	23	of	of	IN
cord-316534-ep7ezoko	403	24	the	the	DT
cord-316534-ep7ezoko	403	25	Merck	Merck	NNP
cord-316534-ep7ezoko	403	26	-	-	HYPH
cord-316534-ep7ezoko	403	27	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	403	28	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	403	29	STEP	STEP	NNP
cord-316534-ep7ezoko	403	30	trial	trial	NN
cord-316534-ep7ezoko	403	31	due	due	IN
cord-316534-ep7ezoko	403	32	to	to	IN
cord-316534-ep7ezoko	403	33	the	the	DT
cord-316534-ep7ezoko	403	34	lack	lack	NN
cord-316534-ep7ezoko	403	35	of	of	IN
cord-316534-ep7ezoko	403	36	efficacy	efficacy	NN
cord-316534-ep7ezoko	403	37	and	and	CC
cord-316534-ep7ezoko	403	38	early	early	JJ
cord-316534-ep7ezoko	403	39	speculation	speculation	NN
cord-316534-ep7ezoko	403	40	that	that	IN
cord-316534-ep7ezoko	403	41	the	the	DT
cord-316534-ep7ezoko	403	42	vaccine	vaccine	NN
cord-316534-ep7ezoko	403	43	might	may	MD
cord-316534-ep7ezoko	403	44	have	have	VB
cord-316534-ep7ezoko	403	45	increased	increase	VBN
cord-316534-ep7ezoko	403	46	the	the	DT
cord-316534-ep7ezoko	403	47	risk	risk	NN
cord-316534-ep7ezoko	403	48	of	of	IN
cord-316534-ep7ezoko	403	49	HIV	HIV	NNP
cord-316534-ep7ezoko	403	50	infection	infection	NN
cord-316534-ep7ezoko	403	51	in	in	IN
cord-316534-ep7ezoko	403	52	some	some	DT
cord-316534-ep7ezoko	403	53	populations	population	NNS
cord-316534-ep7ezoko	403	54	of	of	IN
cord-316534-ep7ezoko	403	55	vaccinees	vaccinee	NNS
cord-316534-ep7ezoko	403	56	.	.	.
cord-316534-ep7ezoko	404	1	In	in	IN
cord-316534-ep7ezoko	404	2	late	late	JJ
cord-316534-ep7ezoko	404	3	2009	2009	CD
cord-316534-ep7ezoko	404	4	,	,	,
cord-316534-ep7ezoko	404	5	promising	promising	JJ
cord-316534-ep7ezoko	404	6	results	result	NNS
cord-316534-ep7ezoko	404	7	came	come	VBD
cord-316534-ep7ezoko	404	8	in	in	RP
cord-316534-ep7ezoko	404	9	from	from	IN
cord-316534-ep7ezoko	404	10	Thailand	Thailand	NNP
cord-316534-ep7ezoko	404	11	in	in	IN
cord-316534-ep7ezoko	404	12	response	response	NN
cord-316534-ep7ezoko	404	13	to	to	IN
cord-316534-ep7ezoko	404	14	their	-PRON-	PRP$
cord-316534-ep7ezoko	404	15	efforts	effort	NNS
cord-316534-ep7ezoko	404	16	to	to	TO
cord-316534-ep7ezoko	404	17	create	create	VB
cord-316534-ep7ezoko	404	18	a	a	DT
cord-316534-ep7ezoko	404	19	safe	safe	JJ
cord-316534-ep7ezoko	404	20	and	and	CC
cord-316534-ep7ezoko	404	21	effective	effective	JJ
cord-316534-ep7ezoko	404	22	vaccine	vaccine	NN
cord-316534-ep7ezoko	404	23	against	against	IN
cord-316534-ep7ezoko	404	24	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	404	25	.	.	.
cord-316534-ep7ezoko	405	1	A	a	DT
cord-316534-ep7ezoko	405	2	community	community	NN
cord-316534-ep7ezoko	405	3	-	-	HYPH
cord-316534-ep7ezoko	405	4	based	base	VBN
cord-316534-ep7ezoko	405	5	,	,	,
cord-316534-ep7ezoko	405	6	randomized	randomized	JJ
cord-316534-ep7ezoko	405	7	,	,	,
cord-316534-ep7ezoko	405	8	multicenter	multicenter	JJ
cord-316534-ep7ezoko	405	9	,	,	,
cord-316534-ep7ezoko	405	10	double	double	JJ
cord-316534-ep7ezoko	405	11	-	-	HYPH
cord-316534-ep7ezoko	405	12	blinded	blinded	JJ
cord-316534-ep7ezoko	405	13	,	,	,
cord-316534-ep7ezoko	405	14	placebo	placebo	NN
cord-316534-ep7ezoko	405	15	-	-	HYPH
cord-316534-ep7ezoko	405	16	controlled	control	VBN
cord-316534-ep7ezoko	405	17	efficacy	efficacy	NN
cord-316534-ep7ezoko	405	18	trial	trial	NN
cord-316534-ep7ezoko	405	19	using	use	VBG
cord-316534-ep7ezoko	405	20	a	a	DT
cord-316534-ep7ezoko	405	21	prime	prime	JJ
cord-316534-ep7ezoko	405	22	-	-	HYPH
cord-316534-ep7ezoko	405	23	boost	boost	NN
cord-316534-ep7ezoko	405	24	combination	combination	NN
cord-316534-ep7ezoko	405	25	showed	show	VBD
cord-316534-ep7ezoko	405	26	31	31	CD
cord-316534-ep7ezoko	405	27	%	%	NN
cord-316534-ep7ezoko	405	28	effectiveness	effectiveness	NN
cord-316534-ep7ezoko	405	29	in	in	IN
cord-316534-ep7ezoko	405	30	preventing	prevent	VBG
cord-316534-ep7ezoko	405	31	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	405	32	infection	infection	NN
cord-316534-ep7ezoko	405	33	.	.	.
cord-316534-ep7ezoko	406	1	These	these	DT
cord-316534-ep7ezoko	406	2	results	result	NNS
cord-316534-ep7ezoko	406	3	lend	lend	VBP
cord-316534-ep7ezoko	406	4	promise	promise	NN
cord-316534-ep7ezoko	406	5	to	to	IN
cord-316534-ep7ezoko	406	6	the	the	DT
cord-316534-ep7ezoko	406	7	hope	hope	NN
cord-316534-ep7ezoko	406	8	of	of	IN
cord-316534-ep7ezoko	406	9	producing	produce	VBG
cord-316534-ep7ezoko	406	10	an	an	DT
cord-316534-ep7ezoko	406	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	406	12	vaccine	vaccine	NN
cord-316534-ep7ezoko	406	13	vector	vector	NN
cord-316534-ep7ezoko	406	14	that	that	WDT
cord-316534-ep7ezoko	406	15	yields	yield	NNS
cord-316534-ep7ezoko	406	16	sterilizing	sterilize	VBG
cord-316534-ep7ezoko	406	17	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	406	18	immunity	immunity	NN
cord-316534-ep7ezoko	406	19	.	.	.
cord-316534-ep7ezoko	407	1	In	in	IN
cord-316534-ep7ezoko	407	2	the	the	DT
cord-316534-ep7ezoko	407	3	future	future	NN
cord-316534-ep7ezoko	407	4	,	,	,
cord-316534-ep7ezoko	407	5	research	research	NN
cord-316534-ep7ezoko	407	6	scientists	scientist	NNS
cord-316534-ep7ezoko	407	7	must	must	MD
cord-316534-ep7ezoko	407	8	work	work	VB
cord-316534-ep7ezoko	407	9	together	together	RB
cord-316534-ep7ezoko	407	10	to	to	TO
cord-316534-ep7ezoko	407	11	increase	increase	VB
cord-316534-ep7ezoko	407	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	407	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	407	14	effectiveness	effectiveness	NN
cord-316534-ep7ezoko	407	15	beyond	beyond	IN
cord-316534-ep7ezoko	407	16	31	31	CD
cord-316534-ep7ezoko	407	17	%	%	NN
cord-316534-ep7ezoko	407	18	.	.	.
cord-316534-ep7ezoko	408	1	Realization	realization	NN
cord-316534-ep7ezoko	408	2	of	of	IN
cord-316534-ep7ezoko	408	3	this	this	DT
cord-316534-ep7ezoko	408	4	goal	goal	NN
cord-316534-ep7ezoko	408	5	may	may	MD
cord-316534-ep7ezoko	408	6	be	be	VB
cord-316534-ep7ezoko	408	7	accomplished	accomplish	VBN
cord-316534-ep7ezoko	408	8	by	by	IN
cord-316534-ep7ezoko	408	9	some	some	DT
cord-316534-ep7ezoko	408	10	of	of	IN
cord-316534-ep7ezoko	408	11	the	the	DT
cord-316534-ep7ezoko	408	12	techniques	technique	NNS
cord-316534-ep7ezoko	408	13	mentioned	mention	VBN
cord-316534-ep7ezoko	408	14	in	in	IN
cord-316534-ep7ezoko	408	15	this	this	DT
cord-316534-ep7ezoko	408	16	review	review	NN
cord-316534-ep7ezoko	408	17	,	,	,
cord-316534-ep7ezoko	408	18	such	such	JJ
cord-316534-ep7ezoko	408	19	as	as	IN
cord-316534-ep7ezoko	408	20	acquisition	acquisition	NN
cord-316534-ep7ezoko	408	21	of	of	IN
cord-316534-ep7ezoko	408	22	HIV	HIV	NNP
cord-316534-ep7ezoko	408	23	mucosal	mucosal	JJ
cord-316534-ep7ezoko	408	24	immunity	immunity	NN
cord-316534-ep7ezoko	408	25	,	,	,
cord-316534-ep7ezoko	408	26	development	development	NN
cord-316534-ep7ezoko	408	27	of	of	IN
cord-316534-ep7ezoko	408	28	effective	effective	JJ
cord-316534-ep7ezoko	408	29	prime	prime	JJ
cord-316534-ep7ezoko	408	30	-	-	HYPH
cord-316534-ep7ezoko	408	31	boost	boost	NN
cord-316534-ep7ezoko	408	32	strategies	strategy	NNS
cord-316534-ep7ezoko	408	33	,	,	,
cord-316534-ep7ezoko	408	34	development	development	NN
cord-316534-ep7ezoko	408	35	of	of	IN
cord-316534-ep7ezoko	408	36	better	well	JJR
cord-316534-ep7ezoko	408	37	animal	animal	NN
cord-316534-ep7ezoko	408	38	models	model	NNS
cord-316534-ep7ezoko	408	39	,	,	,
cord-316534-ep7ezoko	408	40	better	well	JJR
cord-316534-ep7ezoko	408	41	molecular	molecular	JJ
cord-316534-ep7ezoko	408	42	antigen	antigen	NN
cord-316534-ep7ezoko	408	43	modeling	modeling	NN
cord-316534-ep7ezoko	408	44	and	and	CC
cord-316534-ep7ezoko	408	45	presentation	presentation	NN
cord-316534-ep7ezoko	408	46	,	,	,
cord-316534-ep7ezoko	408	47	avoidance	avoidance	NN
cord-316534-ep7ezoko	408	48	of	of	IN
cord-316534-ep7ezoko	408	49	PEI	PEI	NNP
cord-316534-ep7ezoko	408	50	(	(	-LRB-
cord-316534-ep7ezoko	408	51	by	by	IN
cord-316534-ep7ezoko	408	52	the	the	DT
cord-316534-ep7ezoko	408	53	means	mean	NNS
cord-316534-ep7ezoko	408	54	of	of	IN
cord-316534-ep7ezoko	408	55	using	use	VBG
cord-316534-ep7ezoko	408	56	novel	novel	JJ
cord-316534-ep7ezoko	408	57	vector	vector	NN
cord-316534-ep7ezoko	408	58	serotypes	serotype	NNS
cord-316534-ep7ezoko	408	59	in	in	IN
cord-316534-ep7ezoko	408	60	combination	combination	NN
cord-316534-ep7ezoko	408	61	with	with	IN
cord-316534-ep7ezoko	408	62	PEGylation	pegylation	NN
cord-316534-ep7ezoko	408	63	)	)	-RRB-
cord-316534-ep7ezoko	408	64	,	,	,
cord-316534-ep7ezoko	408	65	and/or	and/or	CC
cord-316534-ep7ezoko	408	66	induction	induction	NN
cord-316534-ep7ezoko	408	67	of	of	IN
cord-316534-ep7ezoko	408	68	Nabs	Nabs	NNP
cord-316534-ep7ezoko	408	69	(	(	-LRB-
cord-316534-ep7ezoko	408	70	by	by	IN
cord-316534-ep7ezoko	408	71	means	mean	NNS
cord-316534-ep7ezoko	408	72	of	of	IN
cord-316534-ep7ezoko	408	73	capsid	capsid	NN
cord-316534-ep7ezoko	408	74	incorporation	incorporation	NN
cord-316534-ep7ezoko	408	75	of	of	IN
cord-316534-ep7ezoko	408	76	HIV	HIV	NNP
cord-316534-ep7ezoko	408	77	antigens	antigen	NNS
cord-316534-ep7ezoko	408	78	within	within	IN
cord-316534-ep7ezoko	408	79	viral	viral	JJ
cord-316534-ep7ezoko	408	80	vectors	vector	NNS
cord-316534-ep7ezoko	408	81	)	)	-RRB-
cord-316534-ep7ezoko	408	82	.	.	.
cord-316534-ep7ezoko	409	1	These	these	DT
cord-316534-ep7ezoko	409	2	are	be	VBP
cord-316534-ep7ezoko	409	3	just	just	RB
cord-316534-ep7ezoko	409	4	a	a	DT
cord-316534-ep7ezoko	409	5	few	few	JJ
cord-316534-ep7ezoko	409	6	considerations	consideration	NNS
cord-316534-ep7ezoko	409	7	that	that	WDT
cord-316534-ep7ezoko	409	8	scientists	scientist	NNS
cord-316534-ep7ezoko	409	9	and	and	CC
cord-316534-ep7ezoko	409	10	clinicians	clinician	NNS
cord-316534-ep7ezoko	409	11	must	must	MD
cord-316534-ep7ezoko	409	12	consider	consider	VB
cord-316534-ep7ezoko	409	13	with	with	IN
cord-316534-ep7ezoko	409	14	respect	respect	NN
cord-316534-ep7ezoko	409	15	to	to	IN
cord-316534-ep7ezoko	409	16	the	the	DT
cord-316534-ep7ezoko	409	17	development	development	NN
cord-316534-ep7ezoko	409	18	of	of	IN
cord-316534-ep7ezoko	409	19	an	an	DT
cord-316534-ep7ezoko	409	20	effective	effective	JJ
cord-316534-ep7ezoko	409	21	and	and	CC
cord-316534-ep7ezoko	409	22	safe	safe	JJ
cord-316534-ep7ezoko	409	23	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	409	24	vaccine	vaccine	NN
cord-316534-ep7ezoko	409	25	.	.	.
cord-316534-ep7ezoko	410	1	Scientists	scientist	NNS
cord-316534-ep7ezoko	410	2	and	and	CC
cord-316534-ep7ezoko	410	3	clinicians	clinician	NNS
cord-316534-ep7ezoko	410	4	must	must	MD
cord-316534-ep7ezoko	410	5	also	also	RB
cord-316534-ep7ezoko	410	6	consider	consider	VB
cord-316534-ep7ezoko	410	7	that	that	IN
cord-316534-ep7ezoko	410	8	one	one	CD
cord-316534-ep7ezoko	410	9	vector	vector	NN
cord-316534-ep7ezoko	410	10	or	or	CC
cord-316534-ep7ezoko	410	11	scheme	scheme	NN
cord-316534-ep7ezoko	410	12	may	may	MD
cord-316534-ep7ezoko	410	13	not	not	RB
cord-316534-ep7ezoko	410	14	be	be	VB
cord-316534-ep7ezoko	410	15	sufficient	sufficient	JJ
cord-316534-ep7ezoko	410	16	with	with	IN
cord-316534-ep7ezoko	410	17	respect	respect	NN
cord-316534-ep7ezoko	410	18	to	to	IN
cord-316534-ep7ezoko	410	19	providing	provide	VBG
cord-316534-ep7ezoko	410	20	effective	effective	JJ
cord-316534-ep7ezoko	410	21	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	410	22	immunity	immunity	NN
cord-316534-ep7ezoko	410	23	and	and	CC
cord-316534-ep7ezoko	410	24	some	some	DT
cord-316534-ep7ezoko	410	25	combination	combination	NN
cord-316534-ep7ezoko	410	26	of	of	IN
cord-316534-ep7ezoko	410	27	the	the	DT
cord-316534-ep7ezoko	410	28	above	above	RB
cord-316534-ep7ezoko	410	29	-	-	HYPH
cord-316534-ep7ezoko	410	30	mentioned	mention	VBN
cord-316534-ep7ezoko	410	31	potential	potential	JJ
cord-316534-ep7ezoko	410	32	strategies	strategy	NNS
cord-316534-ep7ezoko	410	33	may	may	MD
cord-316534-ep7ezoko	410	34	offer	offer	VB
cord-316534-ep7ezoko	410	35	the	the	DT
cord-316534-ep7ezoko	410	36	most	most	RBS
cord-316534-ep7ezoko	410	37	promising	promising	JJ
cord-316534-ep7ezoko	410	38	method	method	NN
cord-316534-ep7ezoko	410	39	of	of	IN
cord-316534-ep7ezoko	410	40	producing	produce	VBG
cord-316534-ep7ezoko	410	41	an	an	DT
cord-316534-ep7ezoko	410	42	effective	effective	JJ
cord-316534-ep7ezoko	410	43	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	410	44	prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	410	45	vaccine	vaccine	NN
cord-316534-ep7ezoko	410	46	.	.	.
cord-316534-ep7ezoko	411	1	submit	submit	VB
cord-316534-ep7ezoko	411	2	your	-PRON-	PRP$
cord-316534-ep7ezoko	411	3	manuscript	manuscript	NN
cord-316534-ep7ezoko	411	4	|	|	POS
cord-316534-ep7ezoko	411	5	www.dovepress.com	www.dovepress.com	ADD
cord-316534-ep7ezoko	412	1	Dovepress	Dovepress	NNP
cord-316534-ep7ezoko	412	2	Dovepress	Dovepress	NNP
cord-316534-ep7ezoko	412	3	Report	Report	NNP
cord-316534-ep7ezoko	412	4	on	on	IN
cord-316534-ep7ezoko	412	5	the	the	DT
cord-316534-ep7ezoko	412	6	Global	Global	NNP
cord-316534-ep7ezoko	412	7	AIDS	AIDS	NNP
cord-316534-ep7ezoko	412	8	Epidemic	Epidemic	NNP
cord-316534-ep7ezoko	412	9	Adherence	adherence	NN
cord-316534-ep7ezoko	412	10	to	to	IN
cord-316534-ep7ezoko	412	11	antiretroviral	antiretroviral	JJ
cord-316534-ep7ezoko	412	12	therapy	therapy	NN
cord-316534-ep7ezoko	412	13	:	:	:
cord-316534-ep7ezoko	413	1	a	a	DT
cord-316534-ep7ezoko	413	2	survey	survey	NN
cord-316534-ep7ezoko	413	3	of	of	IN
cord-316534-ep7ezoko	413	4	factors	factor	NNS
cord-316534-ep7ezoko	413	5	associated	associate	VBN
cord-316534-ep7ezoko	413	6	with	with	IN
cord-316534-ep7ezoko	413	7	medication	medication	NN
cord-316534-ep7ezoko	413	8	usage	usage	NN
cord-316534-ep7ezoko	413	9	Lipodystrophy	lipodystrophy	NN
cord-316534-ep7ezoko	413	10	,	,	,
cord-316534-ep7ezoko	413	11	metabolic	metabolic	JJ
cord-316534-ep7ezoko	413	12	disorders	disorder	NNS
cord-316534-ep7ezoko	413	13	,	,	,
cord-316534-ep7ezoko	413	14	and	and	CC
cord-316534-ep7ezoko	413	15	human	human	JJ
cord-316534-ep7ezoko	413	16	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	413	17	virus	virus	NN
cord-316534-ep7ezoko	413	18	infection	infection	NN
cord-316534-ep7ezoko	413	19	:	:	:
cord-316534-ep7ezoko	413	20	Aquitaine	Aquitaine	NNP
cord-316534-ep7ezoko	413	21	Cohort	Cohort	NNP
cord-316534-ep7ezoko	413	22	,	,	,
cord-316534-ep7ezoko	413	23	France	France	NNP
cord-316534-ep7ezoko	413	24	,	,	,
cord-316534-ep7ezoko	413	25	1999	1999	CD
cord-316534-ep7ezoko	413	26	.	.	.
cord-316534-ep7ezoko	414	1	Groupe	Groupe	NNP
cord-316534-ep7ezoko	414	2	d'Epidemiologie	d'Epidemiologie	NNP
cord-316534-ep7ezoko	414	3	Clinique	Clinique	NNP
cord-316534-ep7ezoko	414	4	du	du	NNP
cord-316534-ep7ezoko	414	5	Syndrome	syndrome	NN
cord-316534-ep7ezoko	415	1	d'Immunodeficience	d'Immunodeficience	NNP
cord-316534-ep7ezoko	416	1	Acquise	Acquise	NNP
cord-316534-ep7ezoko	416	2	en	en	IN
cord-316534-ep7ezoko	417	1	Aquitaine	Aquitaine	NNP
cord-316534-ep7ezoko	417	2	A	a	DT
cord-316534-ep7ezoko	417	3	syndrome	syndrome	NN
cord-316534-ep7ezoko	417	4	of	of	IN
cord-316534-ep7ezoko	417	5	lipoatrophy	lipoatrophy	NN
cord-316534-ep7ezoko	417	6	,	,	,
cord-316534-ep7ezoko	417	7	lactic	lactic	JJ
cord-316534-ep7ezoko	417	8	acidaemia	acidaemia	NN
cord-316534-ep7ezoko	417	9	and	and	CC
cord-316534-ep7ezoko	417	10	liver	liver	NN
cord-316534-ep7ezoko	417	11	dysfunction	dysfunction	NN
cord-316534-ep7ezoko	417	12	associated	associate	VBN
cord-316534-ep7ezoko	417	13	with	with	IN
cord-316534-ep7ezoko	417	14	HIV	HIV	NNP
cord-316534-ep7ezoko	417	15	nucleoside	nucleoside	NN
cord-316534-ep7ezoko	417	16	analogue	analogue	NN
cord-316534-ep7ezoko	417	17	therapy	therapy	NN
cord-316534-ep7ezoko	417	18	:	:	:
cord-316534-ep7ezoko	417	19	contribution	contribution	NN
cord-316534-ep7ezoko	417	20	to	to	IN
cord-316534-ep7ezoko	417	21	protease	protease	JJ
cord-316534-ep7ezoko	417	22	inhibitor	inhibitor	NN
cord-316534-ep7ezoko	417	23	-	-	HYPH
cord-316534-ep7ezoko	417	24	related	relate	VBN
cord-316534-ep7ezoko	417	25	lipodystrophy	lipodystrophy	NN
cord-316534-ep7ezoko	417	26	syndrome	syndrome	NN
cord-316534-ep7ezoko	418	1	Longitudinal	longitudinal	JJ
cord-316534-ep7ezoko	418	2	evolution	evolution	NN
cord-316534-ep7ezoko	418	3	of	of	IN
cord-316534-ep7ezoko	418	4	bone	bone	NN
cord-316534-ep7ezoko	418	5	mineral	mineral	NN
cord-316534-ep7ezoko	418	6	density	density	NN
cord-316534-ep7ezoko	418	7	and	and	CC
cord-316534-ep7ezoko	418	8	bone	bone	NN
cord-316534-ep7ezoko	418	9	markers	marker	NNS
cord-316534-ep7ezoko	418	10	in	in	IN
cord-316534-ep7ezoko	418	11	human	human	JJ
cord-316534-ep7ezoko	418	12	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	418	13	virus	virus	NN
cord-316534-ep7ezoko	418	14	-	-	HYPH
cord-316534-ep7ezoko	418	15	infected	infect	VBN
cord-316534-ep7ezoko	418	16	individuals	individual	NNS
cord-316534-ep7ezoko	419	1	The	the	DT
cord-316534-ep7ezoko	419	2	latent	latent	JJ
cord-316534-ep7ezoko	419	3	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	419	4	reservoir	reservoir	NN
cord-316534-ep7ezoko	419	5	in	in	IN
cord-316534-ep7ezoko	419	6	patients	patient	NNS
cord-316534-ep7ezoko	419	7	undergoing	undergo	VBG
cord-316534-ep7ezoko	419	8	HAART	HAART	NNP
cord-316534-ep7ezoko	419	9	:	:	:
cord-316534-ep7ezoko	419	10	an	an	DT
cord-316534-ep7ezoko	419	11	archive	archive	NN
cord-316534-ep7ezoko	419	12	of	of	IN
cord-316534-ep7ezoko	419	13	pre	pre	JJ
cord-316534-ep7ezoko	419	14	-	-	JJ
cord-316534-ep7ezoko	419	15	HAART	haart	JJ
cord-316534-ep7ezoko	419	16	drug	drug	NN
cord-316534-ep7ezoko	419	17	resistance	resistance	NN
cord-316534-ep7ezoko	419	18	Mucosal	Mucosal	NNP
cord-316534-ep7ezoko	419	19	immunity	immunity	NN
cord-316534-ep7ezoko	419	20	to	to	IN
cord-316534-ep7ezoko	419	21	HIV	HIV	NNP
cord-316534-ep7ezoko	419	22	:	:	:
cord-316534-ep7ezoko	419	23	a	a	DT
cord-316534-ep7ezoko	419	24	review	review	NN
cord-316534-ep7ezoko	419	25	of	of	IN
cord-316534-ep7ezoko	419	26	recent	recent	JJ
cord-316534-ep7ezoko	419	27	literature	literature	NN
cord-316534-ep7ezoko	419	28	HIV	HIV	NNP
cord-316534-ep7ezoko	419	29	vaccine	vaccine	NN
cord-316534-ep7ezoko	419	30	design	design	NN
cord-316534-ep7ezoko	419	31	and	and	CC
cord-316534-ep7ezoko	419	32	the	the	DT
cord-316534-ep7ezoko	419	33	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	419	34	antibody	antibody	NN
cord-316534-ep7ezoko	419	35	problem	problem	NN
cord-316534-ep7ezoko	419	36	AIDS	AIDS	NNP
cord-316534-ep7ezoko	419	37	/	/	SYM
cord-316534-ep7ezoko	419	38	HIV	HIV	NNP
cord-316534-ep7ezoko	419	39	.	.	.
cord-316534-ep7ezoko	420	1	Developing	develop	VBG
cord-316534-ep7ezoko	420	2	an	an	DT
cord-316534-ep7ezoko	420	3	AIDS	AIDS	NNP
cord-316534-ep7ezoko	420	4	vaccine	vaccine	NN
cord-316534-ep7ezoko	420	5	:	:	:
cord-316534-ep7ezoko	420	6	need	need	VB
cord-316534-ep7ezoko	420	7	,	,	,
cord-316534-ep7ezoko	420	8	uncertainty	uncertainty	NN
cord-316534-ep7ezoko	420	9	,	,	,
cord-316534-ep7ezoko	420	10	hope	hope	VBP
cord-316534-ep7ezoko	420	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	420	12	vaccine	vaccine	NN
cord-316534-ep7ezoko	420	13	development	development	NN
cord-316534-ep7ezoko	420	14	:	:	:
cord-316534-ep7ezoko	420	15	progress	progress	NN
cord-316534-ep7ezoko	420	16	and	and	CC
cord-316534-ep7ezoko	420	17	prospects	prospect	NNS
cord-316534-ep7ezoko	420	18	T	T	NNP
cord-316534-ep7ezoko	420	19	cell	cell	NN
cord-316534-ep7ezoko	420	20	vaccines	vaccine	NNS
cord-316534-ep7ezoko	420	21	for	for	IN
cord-316534-ep7ezoko	420	22	microbial	microbial	JJ
cord-316534-ep7ezoko	420	23	infections	infection	NNS
cord-316534-ep7ezoko	421	1	The	the	DT
cord-316534-ep7ezoko	421	2	failed	fail	VBN
cord-316534-ep7ezoko	421	3	HIV	HIV	NNP
cord-316534-ep7ezoko	421	4	Merck	Merck	NNP
cord-316534-ep7ezoko	421	5	vaccine	vaccine	NN
cord-316534-ep7ezoko	421	6	study	study	NN
cord-316534-ep7ezoko	421	7	:	:	:
cord-316534-ep7ezoko	421	8	a	a	DT
cord-316534-ep7ezoko	421	9	step	step	NN
cord-316534-ep7ezoko	421	10	back	back	RB
cord-316534-ep7ezoko	421	11	or	or	CC
cord-316534-ep7ezoko	421	12	a	a	DT
cord-316534-ep7ezoko	421	13	launching	launching	JJ
cord-316534-ep7ezoko	421	14	point	point	NN
cord-316534-ep7ezoko	421	15	for	for	IN
cord-316534-ep7ezoko	421	16	future	future	JJ
cord-316534-ep7ezoko	421	17	vaccine	vaccine	NN
cord-316534-ep7ezoko	421	18	development	development	NN
cord-316534-ep7ezoko	421	19	?	?	.
cord-316534-ep7ezoko	422	1	Protection	protection	NN
cord-316534-ep7ezoko	422	2	by	by	IN
cord-316534-ep7ezoko	422	3	attenuated	attenuated	JJ
cord-316534-ep7ezoko	422	4	simian	simian	JJ
cord-316534-ep7ezoko	422	5	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	422	6	virus	virus	NN
cord-316534-ep7ezoko	422	7	in	in	IN
cord-316534-ep7ezoko	422	8	macaques	macaque	NNS
cord-316534-ep7ezoko	422	9	against	against	IN
cord-316534-ep7ezoko	422	10	challenge	challenge	NN
cord-316534-ep7ezoko	422	11	with	with	IN
cord-316534-ep7ezoko	422	12	virus	virus	NN
cord-316534-ep7ezoko	422	13	-	-	HYPH
cord-316534-ep7ezoko	422	14	infected	infect	VBN
cord-316534-ep7ezoko	422	15	cells	cell	NNS
cord-316534-ep7ezoko	422	16	Rapid	rapid	JJ
cord-316534-ep7ezoko	422	17	development	development	NN
cord-316534-ep7ezoko	422	18	of	of	IN
cord-316534-ep7ezoko	422	19	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	20	protection	protection	NN
cord-316534-ep7ezoko	422	21	in	in	IN
cord-316534-ep7ezoko	422	22	macaques	macaque	NNS
cord-316534-ep7ezoko	422	23	by	by	IN
cord-316534-ep7ezoko	422	24	live	live	RB
cord-316534-ep7ezoko	422	25	-	-	HYPH
cord-316534-ep7ezoko	422	26	attenuated	attenuate	VBN
cord-316534-ep7ezoko	422	27	simian	simian	JJ
cord-316534-ep7ezoko	422	28	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	422	29	virus	virus	NN
cord-316534-ep7ezoko	422	30	Long	long	JJ
cord-316534-ep7ezoko	422	31	-	-	HYPH
cord-316534-ep7ezoko	422	32	term	term	NN
cord-316534-ep7ezoko	422	33	symptomless	symptomless	JJ
cord-316534-ep7ezoko	422	34	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	422	35	infection	infection	NN
cord-316534-ep7ezoko	422	36	in	in	IN
cord-316534-ep7ezoko	422	37	recipients	recipient	NNS
cord-316534-ep7ezoko	422	38	of	of	IN
cord-316534-ep7ezoko	422	39	blood	blood	NN
cord-316534-ep7ezoko	422	40	products	product	NNS
cord-316534-ep7ezoko	422	41	from	from	IN
cord-316534-ep7ezoko	422	42	a	a	DT
cord-316534-ep7ezoko	422	43	single	single	JJ
cord-316534-ep7ezoko	422	44	donor	donor	NN
cord-316534-ep7ezoko	422	45	Genetic	genetic	JJ
cord-316534-ep7ezoko	422	46	instability	instability	NN
cord-316534-ep7ezoko	422	47	of	of	IN
cord-316534-ep7ezoko	422	48	live	live	JJ
cord-316534-ep7ezoko	422	49	,	,	,
cord-316534-ep7ezoko	422	50	attenuated	attenuated	JJ
cord-316534-ep7ezoko	422	51	human	human	JJ
cord-316534-ep7ezoko	422	52	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	422	53	virus	virus	NN
cord-316534-ep7ezoko	422	54	type	type	NN
cord-316534-ep7ezoko	422	55	1	1	CD
cord-316534-ep7ezoko	422	56	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	57	strains	strain	NNS
cord-316534-ep7ezoko	422	58	Update	update	VBP
cord-316534-ep7ezoko	422	59	on	on	IN
cord-316534-ep7ezoko	422	60	long	long	JJ
cord-316534-ep7ezoko	422	61	-	-	HYPH
cord-316534-ep7ezoko	422	62	term	term	NN
cord-316534-ep7ezoko	422	63	symptomless	symptomless	JJ
cord-316534-ep7ezoko	422	64	HIV	HIV	NNP
cord-316534-ep7ezoko	422	65	type	type	NN
cord-316534-ep7ezoko	422	66	1	1	CD
cord-316534-ep7ezoko	422	67	infection	infection	NN
cord-316534-ep7ezoko	422	68	in	in	IN
cord-316534-ep7ezoko	422	69	recipients	recipient	NNS
cord-316534-ep7ezoko	422	70	of	of	IN
cord-316534-ep7ezoko	422	71	blood	blood	NN
cord-316534-ep7ezoko	422	72	products	product	NNS
cord-316534-ep7ezoko	422	73	from	from	IN
cord-316534-ep7ezoko	422	74	a	a	DT
cord-316534-ep7ezoko	422	75	single	single	JJ
cord-316534-ep7ezoko	422	76	donor	donor	NN
cord-316534-ep7ezoko	422	77	HIV	HIV	NNP
cord-316534-ep7ezoko	422	78	vaccines	vaccine	NNS
cord-316534-ep7ezoko	422	79	:	:	:
cord-316534-ep7ezoko	422	80	new	new	JJ
cord-316534-ep7ezoko	422	81	frontiers	frontier	NNS
cord-316534-ep7ezoko	422	82	in	in	IN
cord-316534-ep7ezoko	422	83	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	84	development	development	NN
cord-316534-ep7ezoko	422	85	Placebo	Placebo	NNP
cord-316534-ep7ezoko	422	86	-	-	HYPH
cord-316534-ep7ezoko	422	87	controlled	control	VBN
cord-316534-ep7ezoko	422	88	phase	phase	NN
cord-316534-ep7ezoko	422	89	3	3	CD
cord-316534-ep7ezoko	422	90	trial	trial	NN
cord-316534-ep7ezoko	422	91	of	of	IN
cord-316534-ep7ezoko	422	92	a	a	DT
cord-316534-ep7ezoko	422	93	recombinant	recombinant	JJ
cord-316534-ep7ezoko	422	94	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	422	95	120	120	CD
cord-316534-ep7ezoko	422	96	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	97	to	to	TO
cord-316534-ep7ezoko	422	98	prevent	prevent	VB
cord-316534-ep7ezoko	422	99	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	422	100	infection	infection	NN
cord-316534-ep7ezoko	422	101	Correlation	correlation	NN
cord-316534-ep7ezoko	422	102	between	between	IN
cord-316534-ep7ezoko	422	103	immunologic	immunologic	JJ
cord-316534-ep7ezoko	422	104	responses	response	NNS
cord-316534-ep7ezoko	422	105	to	to	IN
cord-316534-ep7ezoko	422	106	a	a	DT
cord-316534-ep7ezoko	422	107	recombinant	recombinant	JJ
cord-316534-ep7ezoko	422	108	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	422	109	120	120	CD
cord-316534-ep7ezoko	422	110	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	111	and	and	CC
cord-316534-ep7ezoko	422	112	incidence	incidence	NN
cord-316534-ep7ezoko	422	113	of	of	IN
cord-316534-ep7ezoko	422	114	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	422	115	infection	infection	NN
cord-316534-ep7ezoko	422	116	in	in	IN
cord-316534-ep7ezoko	422	117	a	a	DT
cord-316534-ep7ezoko	422	118	phase	phase	NN
cord-316534-ep7ezoko	422	119	3	3	CD
cord-316534-ep7ezoko	422	120	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	422	121	preventive	preventive	JJ
cord-316534-ep7ezoko	422	122	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	123	trial	trial	NN
cord-316534-ep7ezoko	422	124	Lessons	lesson	NNS
cord-316534-ep7ezoko	422	125	from	from	IN
cord-316534-ep7ezoko	422	126	failure	failure	NN
cord-316534-ep7ezoko	422	127	-preparing	-prepare	VBG
cord-316534-ep7ezoko	422	128	for	for	IN
cord-316534-ep7ezoko	422	129	future	future	JJ
cord-316534-ep7ezoko	422	130	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	422	131	vaccine	vaccine	NN
cord-316534-ep7ezoko	422	132	efficacy	efficacy	NN
cord-316534-ep7ezoko	422	133	trials	trial	NNS
cord-316534-ep7ezoko	423	1	Randomized	randomized	JJ
cord-316534-ep7ezoko	423	2	,	,	,
cord-316534-ep7ezoko	423	3	double	double	JJ
cord-316534-ep7ezoko	423	4	-	-	HYPH
cord-316534-ep7ezoko	423	5	blind	blind	JJ
cord-316534-ep7ezoko	423	6	,	,	,
cord-316534-ep7ezoko	423	7	placebo	placebo	NN
cord-316534-ep7ezoko	423	8	-	-	HYPH
cord-316534-ep7ezoko	423	9	controlled	control	VBN
cord-316534-ep7ezoko	423	10	efficacy	efficacy	NN
cord-316534-ep7ezoko	423	11	trial	trial	NN
cord-316534-ep7ezoko	423	12	of	of	IN
cord-316534-ep7ezoko	423	13	a	a	DT
cord-316534-ep7ezoko	423	14	bivalent	bivalent	JJ
cord-316534-ep7ezoko	423	15	recombinant	recombinant	NN
cord-316534-ep7ezoko	423	16	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	423	17	120	120	CD
cord-316534-ep7ezoko	423	18	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	423	19	vaccine	vaccine	NN
cord-316534-ep7ezoko	423	20	among	among	IN
cord-316534-ep7ezoko	423	21	injection	injection	NN
cord-316534-ep7ezoko	423	22	drug	drug	NN
cord-316534-ep7ezoko	423	23	users	user	NNS
cord-316534-ep7ezoko	423	24	in	in	IN
cord-316534-ep7ezoko	423	25	Global	Global	NNP
cord-316534-ep7ezoko	423	26	and	and	CC
cord-316534-ep7ezoko	423	27	regional	regional	JJ
cord-316534-ep7ezoko	423	28	distribution	distribution	NN
cord-316534-ep7ezoko	423	29	of	of	IN
cord-316534-ep7ezoko	423	30	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	423	31	genetic	genetic	JJ
cord-316534-ep7ezoko	423	32	subtypes	subtype	NNS
cord-316534-ep7ezoko	423	33	and	and	CC
cord-316534-ep7ezoko	423	34	recombinants	recombinant	NNS
cord-316534-ep7ezoko	423	35	in	in	IN
cord-316534-ep7ezoko	423	36	2004	2004	CD
cord-316534-ep7ezoko	424	1	A	a	DT
cord-316534-ep7ezoko	424	2	new	new	JJ
cord-316534-ep7ezoko	424	3	human	human	JJ
cord-316534-ep7ezoko	424	4	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	424	5	virus	virus	NN
cord-316534-ep7ezoko	424	6	derived	derive	VBN
cord-316534-ep7ezoko	424	7	from	from	IN
cord-316534-ep7ezoko	424	8	gorillas	gorilla	NNS
cord-316534-ep7ezoko	424	9	Preferential	preferential	JJ
cord-316534-ep7ezoko	424	10	in	in	IN
cord-316534-ep7ezoko	424	11	-	-	HYPH
cord-316534-ep7ezoko	424	12	utero	utero	NN
cord-316534-ep7ezoko	424	13	transmission	transmission	NN
cord-316534-ep7ezoko	424	14	of	of	IN
cord-316534-ep7ezoko	424	15	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	424	16	subtype	subtype	NN
cord-316534-ep7ezoko	424	17	C	C	NNP
cord-316534-ep7ezoko	424	18	as	as	IN
cord-316534-ep7ezoko	424	19	compared	compare	VBN
cord-316534-ep7ezoko	424	20	to	to	IN
cord-316534-ep7ezoko	424	21	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	424	22	subtype	subtype	NN
cord-316534-ep7ezoko	424	23	A	A	NNP
cord-316534-ep7ezoko	424	24	or	or	CC
cord-316534-ep7ezoko	424	25	D	D	NNP
cord-316534-ep7ezoko	424	26	Cell	cell	NN
cord-316534-ep7ezoko	424	27	reservoirs	reservoir	NNS
cord-316534-ep7ezoko	424	28	in	in	IN
cord-316534-ep7ezoko	424	29	lymph	lymph	NN
cord-316534-ep7ezoko	424	30	nodes	node	NNS
cord-316534-ep7ezoko	424	31	infected	infect	VBN
cord-316534-ep7ezoko	424	32	with	with	IN
cord-316534-ep7ezoko	424	33	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	424	34	subtype	subtype	NN
cord-316534-ep7ezoko	424	35	E	e	NN
cord-316534-ep7ezoko	424	36	differ	differ	VBP
cord-316534-ep7ezoko	424	37	from	from	IN
cord-316534-ep7ezoko	424	38	subtype	subtype	NN
cord-316534-ep7ezoko	424	39	B	b	NN
cord-316534-ep7ezoko	424	40	:	:	:
cord-316534-ep7ezoko	424	41	identification	identification	NN
cord-316534-ep7ezoko	424	42	by	by	IN
cord-316534-ep7ezoko	424	43	combined	combine	VBN
cord-316534-ep7ezoko	424	44	in	in	IN
cord-316534-ep7ezoko	424	45	situ	situ	NN
cord-316534-ep7ezoko	424	46	polymerase	polymerase	NN
cord-316534-ep7ezoko	424	47	chain	chain	NN
cord-316534-ep7ezoko	424	48	reaction	reaction	NN
cord-316534-ep7ezoko	424	49	and	and	CC
cord-316534-ep7ezoko	424	50	immunohistochemistry	immunohistochemistry	NN
cord-316534-ep7ezoko	424	51	Different	different	JJ
cord-316534-ep7ezoko	424	52	rates	rate	NNS
cord-316534-ep7ezoko	424	53	of	of	IN
cord-316534-ep7ezoko	424	54	disease	disease	NN
cord-316534-ep7ezoko	424	55	progression	progression	NN
cord-316534-ep7ezoko	424	56	of	of	IN
cord-316534-ep7ezoko	424	57	HIV	HIV	NNP
cord-316534-ep7ezoko	424	58	type	type	NN
cord-316534-ep7ezoko	424	59	1	1	CD
cord-316534-ep7ezoko	424	60	infection	infection	NN
cord-316534-ep7ezoko	424	61	in	in	IN
cord-316534-ep7ezoko	424	62	Tanzania	Tanzania	NNP
cord-316534-ep7ezoko	424	63	based	base	VBN
cord-316534-ep7ezoko	424	64	on	on	IN
cord-316534-ep7ezoko	424	65	infecting	infect	VBG
cord-316534-ep7ezoko	424	66	subtype	subtype	NN
cord-316534-ep7ezoko	424	67	Relation	relation	NN
cord-316534-ep7ezoko	424	68	between	between	IN
cord-316534-ep7ezoko	424	69	chemokine	chemokine	NN
cord-316534-ep7ezoko	424	70	receptor	receptor	NN
cord-316534-ep7ezoko	424	71	use	use	NN
cord-316534-ep7ezoko	424	72	,	,	,
cord-316534-ep7ezoko	424	73	disease	disease	NN
cord-316534-ep7ezoko	424	74	stage	stage	NN
cord-316534-ep7ezoko	424	75	,	,	,
cord-316534-ep7ezoko	424	76	and	and	CC
cord-316534-ep7ezoko	424	77	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	424	78	subtypes	subtype	NNS
cord-316534-ep7ezoko	424	79	A	A	NNP
cord-316534-ep7ezoko	424	80	and	and	CC
cord-316534-ep7ezoko	424	81	D	d	NN
cord-316534-ep7ezoko	424	82	:	:	:
cord-316534-ep7ezoko	424	83	results	result	NNS
cord-316534-ep7ezoko	424	84	from	from	IN
cord-316534-ep7ezoko	424	85	a	a	DT
cord-316534-ep7ezoko	424	86	rural	rural	JJ
cord-316534-ep7ezoko	424	87	Ugandan	ugandan	JJ
cord-316534-ep7ezoko	424	88	cohort	cohort	NN
cord-316534-ep7ezoko	424	89	Escape	Escape	NNP
cord-316534-ep7ezoko	424	90	artist	artist	NN
cord-316534-ep7ezoko	424	91	par	par	NN
cord-316534-ep7ezoko	424	92	excellence	excellence	NN
cord-316534-ep7ezoko	425	1	Genetic	genetic	JJ
cord-316534-ep7ezoko	425	2	subtypes	subtype	NNS
cord-316534-ep7ezoko	425	3	,	,	,
cord-316534-ep7ezoko	425	4	humoral	humoral	JJ
cord-316534-ep7ezoko	425	5	immunity	immunity	NN
cord-316534-ep7ezoko	425	6	,	,	,
cord-316534-ep7ezoko	425	7	and	and	CC
cord-316534-ep7ezoko	425	8	human	human	JJ
cord-316534-ep7ezoko	425	9	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	425	10	virus	virus	NN
cord-316534-ep7ezoko	425	11	type	type	NN
cord-316534-ep7ezoko	425	12	1	1	CD
cord-316534-ep7ezoko	425	13	vaccine	vaccine	NN
cord-316534-ep7ezoko	425	14	development	development	NN
cord-316534-ep7ezoko	425	15	Viral	viral	JJ
cord-316534-ep7ezoko	425	16	sequence	sequence	NN
cord-316534-ep7ezoko	425	17	diversity	diversity	NN
cord-316534-ep7ezoko	425	18	:	:	:
cord-316534-ep7ezoko	425	19	challenges	challenge	NNS
cord-316534-ep7ezoko	425	20	for	for	IN
cord-316534-ep7ezoko	425	21	AIDS	AIDS	NNP
cord-316534-ep7ezoko	425	22	vaccine	vaccine	NN
cord-316534-ep7ezoko	425	23	designs	design	VBZ
cord-316534-ep7ezoko	425	24	Standardized	standardized	JJ
cord-316534-ep7ezoko	425	25	assessment	assessment	NN
cord-316534-ep7ezoko	425	26	of	of	IN
cord-316534-ep7ezoko	425	27	NAb	nab	JJ
cord-316534-ep7ezoko	425	28	responses	response	NNS
cord-316534-ep7ezoko	425	29	elicited	elicit	VBN
cord-316534-ep7ezoko	425	30	in	in	IN
cord-316534-ep7ezoko	425	31	rhesus	rhesu	NNS
cord-316534-ep7ezoko	425	32	monkeys	monkey	NNS
cord-316534-ep7ezoko	425	33	immunized	immunize	VBN
cord-316534-ep7ezoko	425	34	with	with	IN
cord-316534-ep7ezoko	425	35	single	single	JJ
cord-316534-ep7ezoko	425	36	-	-	HYPH
cord-316534-ep7ezoko	425	37	or	or	CC
cord-316534-ep7ezoko	425	38	multi	multi	JJ
cord-316534-ep7ezoko	425	39	-	-	JJ
cord-316534-ep7ezoko	425	40	clade	clade	JJ
cord-316534-ep7ezoko	425	41	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	425	42	envelope	envelope	NN
cord-316534-ep7ezoko	425	43	immunogens	immunogen	NNS
cord-316534-ep7ezoko	426	1	A	a	DT
cord-316534-ep7ezoko	426	2	phase	phase	NN
cord-316534-ep7ezoko	426	3	1/2	1/2	CD
cord-316534-ep7ezoko	426	4	study	study	NN
cord-316534-ep7ezoko	426	5	of	of	IN
cord-316534-ep7ezoko	426	6	a	a	DT
cord-316534-ep7ezoko	426	7	multiclade	multiclade	NNP
cord-316534-ep7ezoko	426	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	426	9	DNA	DNA	NNP
cord-316534-ep7ezoko	426	10	plasmid	plasmid	NN
cord-316534-ep7ezoko	426	11	prime	prime	NN
cord-316534-ep7ezoko	426	12	and	and	CC
cord-316534-ep7ezoko	426	13	recombinant	recombinant	JJ
cord-316534-ep7ezoko	426	14	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	426	15	serotype	serotype	NN
cord-316534-ep7ezoko	426	16	5	5	CD
cord-316534-ep7ezoko	426	17	boost	boost	NN
cord-316534-ep7ezoko	426	18	vaccine	vaccine	NN
cord-316534-ep7ezoko	426	19	in	in	IN
cord-316534-ep7ezoko	426	20	HIV	HIV	NNP
cord-316534-ep7ezoko	426	21	-	-	HYPH
cord-316534-ep7ezoko	426	22	Uninfected	Uninfected	NNP
cord-316534-ep7ezoko	426	23	East	East	NNP
cord-316534-ep7ezoko	426	24	Africans	Africans	NNPS
cord-316534-ep7ezoko	426	25	(	(	-LRB-
cord-316534-ep7ezoko	426	26	RV	RV	NNP
cord-316534-ep7ezoko	426	27	172	172	CD
cord-316534-ep7ezoko	426	28	)	)	-RRB-
cord-316534-ep7ezoko	427	1	Mosaic	mosaic	JJ
cord-316534-ep7ezoko	427	2	vaccines	vaccine	NNS
cord-316534-ep7ezoko	427	3	elicit	elicit	VBP
cord-316534-ep7ezoko	427	4	CD8(+	cd8(+	CD
cord-316534-ep7ezoko	427	5	)	)	-RRB-
cord-316534-ep7ezoko	427	6	T	t	NN
cord-316534-ep7ezoko	427	7	lymphocyte	lymphocyte	NN
cord-316534-ep7ezoko	427	8	responses	response	NNS
cord-316534-ep7ezoko	427	9	that	that	WDT
cord-316534-ep7ezoko	427	10	confer	confer	VBP
cord-316534-ep7ezoko	427	11	enhanced	enhanced	JJ
cord-316534-ep7ezoko	427	12	immune	immune	JJ
cord-316534-ep7ezoko	427	13	coverage	coverage	NN
cord-316534-ep7ezoko	427	14	of	of	IN
cord-316534-ep7ezoko	427	15	diverse	diverse	JJ
cord-316534-ep7ezoko	427	16	HIV	HIV	NNP
cord-316534-ep7ezoko	427	17	strains	strain	NNS
cord-316534-ep7ezoko	427	18	in	in	IN
cord-316534-ep7ezoko	427	19	monkeys	monkey	NNS
cord-316534-ep7ezoko	427	20	HIV	HIV	NNP
cord-316534-ep7ezoko	427	21	vaccines	vaccine	NNS
cord-316534-ep7ezoko	427	22	:	:	:
cord-316534-ep7ezoko	427	23	mosaic	mosaic	JJ
cord-316534-ep7ezoko	427	24	approach	approach	NN
cord-316534-ep7ezoko	427	25	to	to	IN
cord-316534-ep7ezoko	427	26	virus	virus	NN
cord-316534-ep7ezoko	427	27	diversity	diversity	NN
cord-316534-ep7ezoko	428	1	Mosaic	Mosaic	NNP
cord-316534-ep7ezoko	428	2	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	428	3	vaccines	vaccine	NNS
cord-316534-ep7ezoko	428	4	expand	expand	VBP
cord-316534-ep7ezoko	428	5	the	the	DT
cord-316534-ep7ezoko	428	6	breadth	breadth	NN
cord-316534-ep7ezoko	428	7	and	and	CC
cord-316534-ep7ezoko	428	8	depth	depth	NN
cord-316534-ep7ezoko	428	9	of	of	IN
cord-316534-ep7ezoko	428	10	cellular	cellular	JJ
cord-316534-ep7ezoko	428	11	immune	immune	JJ
cord-316534-ep7ezoko	428	12	responses	response	NNS
cord-316534-ep7ezoko	428	13	in	in	IN
cord-316534-ep7ezoko	428	14	rhesus	rhesu	NNS
cord-316534-ep7ezoko	428	15	monkeys	monkey	NNS
cord-316534-ep7ezoko	428	16	Antibody	Antibody	NNP
cord-316534-ep7ezoko	428	17	protects	protect	VBZ
cord-316534-ep7ezoko	428	18	macaques	macaque	NNS
cord-316534-ep7ezoko	428	19	against	against	IN
cord-316534-ep7ezoko	428	20	vaginal	vaginal	JJ
cord-316534-ep7ezoko	428	21	challenge	challenge	NN
cord-316534-ep7ezoko	428	22	with	with	IN
cord-316534-ep7ezoko	428	23	a	a	DT
cord-316534-ep7ezoko	428	24	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	428	25	R5	R5	NNP
cord-316534-ep7ezoko	428	26	simian	simian	JJ
cord-316534-ep7ezoko	428	27	/	/	SYM
cord-316534-ep7ezoko	428	28	human	human	JJ
cord-316534-ep7ezoko	428	29	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	428	30	virus	virus	NN
cord-316534-ep7ezoko	428	31	at	at	IN
cord-316534-ep7ezoko	428	32	serum	serum	NN
cord-316534-ep7ezoko	428	33	levels	level	NNS
cord-316534-ep7ezoko	428	34	giving	give	VBG
cord-316534-ep7ezoko	428	35	complete	complete	JJ
cord-316534-ep7ezoko	428	36	neutralization	neutralization	NN
cord-316534-ep7ezoko	428	37	in	in	IN
cord-316534-ep7ezoko	428	38	vitro	vitro	FW
cord-316534-ep7ezoko	428	39	Human	human	JJ
cord-316534-ep7ezoko	428	40	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	428	41	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	428	42	antibodies	antibody	NNS
cord-316534-ep7ezoko	428	43	of	of	IN
cord-316534-ep7ezoko	428	44	the	the	DT
cord-316534-ep7ezoko	428	45	IgG1	IgG1	NNP
cord-316534-ep7ezoko	428	46	subtype	subtype	NN
cord-316534-ep7ezoko	428	47	protect	protect	VB
cord-316534-ep7ezoko	428	48	against	against	IN
cord-316534-ep7ezoko	428	49	mucosal	mucosal	JJ
cord-316534-ep7ezoko	428	50	simian	simian	JJ
cord-316534-ep7ezoko	428	51	-	-	HYPH
cord-316534-ep7ezoko	428	52	human	human	JJ
cord-316534-ep7ezoko	428	53	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	428	54	virus	virus	NN
cord-316534-ep7ezoko	428	55	infection	infection	NN
cord-316534-ep7ezoko	428	56	Protection	Protection	NNP
cord-316534-ep7ezoko	428	57	of	of	IN
cord-316534-ep7ezoko	428	58	macaques	macaque	NNS
cord-316534-ep7ezoko	428	59	against	against	IN
cord-316534-ep7ezoko	428	60	vaginal	vaginal	JJ
cord-316534-ep7ezoko	428	61	transmission	transmission	NN
cord-316534-ep7ezoko	428	62	of	of	IN
cord-316534-ep7ezoko	428	63	a	a	DT
cord-316534-ep7ezoko	428	64	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	428	65	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	428	66	/	/	SYM
cord-316534-ep7ezoko	428	67	SIV	SIV	NNP
cord-316534-ep7ezoko	428	68	chimeric	chimeric	JJ
cord-316534-ep7ezoko	428	69	virus	virus	NN
cord-316534-ep7ezoko	428	70	by	by	IN
cord-316534-ep7ezoko	428	71	passive	passive	JJ
cord-316534-ep7ezoko	428	72	infusion	infusion	NN
cord-316534-ep7ezoko	428	73	of	of	IN
cord-316534-ep7ezoko	428	74	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	428	75	antibodies	antibody	NNS
cord-316534-ep7ezoko	428	76	Evolutionary	evolutionary	JJ
cord-316534-ep7ezoko	428	77	and	and	CC
cord-316534-ep7ezoko	428	78	immunological	immunological	JJ
cord-316534-ep7ezoko	428	79	implications	implication	NNS
cord-316534-ep7ezoko	428	80	of	of	IN
cord-316534-ep7ezoko	428	81	contemporary	contemporary	JJ
cord-316534-ep7ezoko	428	82	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	428	83	variation	variation	NN
cord-316534-ep7ezoko	428	84	The	the	DT
cord-316534-ep7ezoko	428	85	antigenic	antigenic	JJ
cord-316534-ep7ezoko	428	86	structure	structure	NN
cord-316534-ep7ezoko	428	87	of	of	IN
cord-316534-ep7ezoko	428	88	the	the	DT
cord-316534-ep7ezoko	428	89	HIV	HIV	NNP
cord-316534-ep7ezoko	428	90	gp120	gp120	NNP
cord-316534-ep7ezoko	428	91	envelope	envelope	NN
cord-316534-ep7ezoko	428	92	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	428	93	Structure	structure	NN
cord-316534-ep7ezoko	428	94	of	of	IN
cord-316534-ep7ezoko	428	95	an	an	DT
cord-316534-ep7ezoko	428	96	HIV	HIV	NNP
cord-316534-ep7ezoko	428	97	gp120	gp120	NNP
cord-316534-ep7ezoko	428	98	envelope	envelope	NN
cord-316534-ep7ezoko	428	99	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	428	100	in	in	IN
cord-316534-ep7ezoko	428	101	complex	complex	NN
cord-316534-ep7ezoko	428	102	with	with	IN
cord-316534-ep7ezoko	428	103	the	the	DT
cord-316534-ep7ezoko	428	104	CD4	CD4	NNP
cord-316534-ep7ezoko	428	105	receptor	receptor	NN
cord-316534-ep7ezoko	428	106	and	and	CC
cord-316534-ep7ezoko	428	107	a	a	DT
cord-316534-ep7ezoko	428	108	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	428	109	human	human	JJ
cord-316534-ep7ezoko	428	110	antibody	antibody	NN
cord-316534-ep7ezoko	428	111	Antibody	Antibody	NNP
cord-316534-ep7ezoko	428	112	neutralization	neutralization	NN
cord-316534-ep7ezoko	428	113	and	and	CC
cord-316534-ep7ezoko	428	114	escape	escape	NN
cord-316534-ep7ezoko	428	115	by	by	IN
cord-316534-ep7ezoko	428	116	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	428	117	Cell	Cell	NNP
cord-316534-ep7ezoko	428	118	entry	entry	NN
cord-316534-ep7ezoko	428	119	by	by	IN
cord-316534-ep7ezoko	428	120	enveloped	envelop	VBN
cord-316534-ep7ezoko	428	121	viruses	virus	NNS
cord-316534-ep7ezoko	428	122	:	:	:
cord-316534-ep7ezoko	428	123	redox	redox	JJ
cord-316534-ep7ezoko	428	124	considerations	consideration	NNS
cord-316534-ep7ezoko	428	125	for	for	IN
cord-316534-ep7ezoko	428	126	HIV	HIV	NNP
cord-316534-ep7ezoko	428	127	and	and	CC
cord-316534-ep7ezoko	428	128	SARS	SARS	NNP
cord-316534-ep7ezoko	428	129	-	-	HYPH
cord-316534-ep7ezoko	428	130	coronavirus	coronavirus	NN
cord-316534-ep7ezoko	428	131	Antibodies	antibody	NNS
cord-316534-ep7ezoko	428	132	to	to	IN
cord-316534-ep7ezoko	428	133	CD4-induced	cd4-induce	VBN
cord-316534-ep7ezoko	428	134	sites	site	NNS
cord-316534-ep7ezoko	428	135	in	in	IN
cord-316534-ep7ezoko	428	136	HIV	HIV	NNP
cord-316534-ep7ezoko	429	1	gp120	gp120	NNP
cord-316534-ep7ezoko	429	2	correlate	correlate	VBP
cord-316534-ep7ezoko	429	3	with	with	IN
cord-316534-ep7ezoko	429	4	the	the	DT
cord-316534-ep7ezoko	429	5	control	control	NN
cord-316534-ep7ezoko	429	6	of	of	IN
cord-316534-ep7ezoko	429	7	SHIV	SHIV	NNP
cord-316534-ep7ezoko	429	8	challenge	challenge	NN
cord-316534-ep7ezoko	429	9	in	in	IN
cord-316534-ep7ezoko	429	10	macaques	macaque	NNS
cord-316534-ep7ezoko	429	11	vaccinated	vaccinate	VBN
cord-316534-ep7ezoko	429	12	with	with	IN
cord-316534-ep7ezoko	429	13	subunit	subunit	NN
cord-316534-ep7ezoko	429	14	immunogens	immunogen	VBZ
cord-316534-ep7ezoko	429	15	Broad	Broad	NNP
cord-316534-ep7ezoko	429	16	and	and	CC
cord-316534-ep7ezoko	429	17	potent	potent	JJ
cord-316534-ep7ezoko	429	18	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	429	19	antibodies	antibody	NNS
cord-316534-ep7ezoko	429	20	from	from	IN
cord-316534-ep7ezoko	429	21	an	an	DT
cord-316534-ep7ezoko	429	22	African	african	JJ
cord-316534-ep7ezoko	429	23	donor	donor	NN
cord-316534-ep7ezoko	429	24	reveal	reveal	VBP
cord-316534-ep7ezoko	429	25	a	a	DT
cord-316534-ep7ezoko	429	26	new	new	JJ
cord-316534-ep7ezoko	429	27	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	429	28	vaccine	vaccine	NN
cord-316534-ep7ezoko	429	29	target	target	VB
cord-316534-ep7ezoko	429	30	Efficient	efficient	JJ
cord-316534-ep7ezoko	429	31	neutralization	neutralization	NN
cord-316534-ep7ezoko	429	32	of	of	IN
cord-316534-ep7ezoko	429	33	primary	primary	JJ
cord-316534-ep7ezoko	429	34	isolates	isolate	NNS
cord-316534-ep7ezoko	429	35	of	of	IN
cord-316534-ep7ezoko	429	36	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	429	37	by	by	IN
cord-316534-ep7ezoko	429	38	a	a	DT
cord-316534-ep7ezoko	429	39	recombinant	recombinant	JJ
cord-316534-ep7ezoko	429	40	human	human	JJ
cord-316534-ep7ezoko	429	41	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	429	42	antibody	antibody	NN
cord-316534-ep7ezoko	429	43	.	.	.
cord-316534-ep7ezoko	430	1	Science	Science	NNP
cord-316534-ep7ezoko	430	2	A	a	DT
cord-316534-ep7ezoko	430	3	conserved	conserve	VBN
cord-316534-ep7ezoko	430	4	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	430	5	epitope	epitope	NN
cord-316534-ep7ezoko	430	6	on	on	IN
cord-316534-ep7ezoko	430	7	gp41	gp41	NNP
cord-316534-ep7ezoko	430	8	of	of	IN
cord-316534-ep7ezoko	430	9	human	human	JJ
cord-316534-ep7ezoko	430	10	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	430	11	virus	virus	NN
cord-316534-ep7ezoko	430	12	type	type	NN
cord-316534-ep7ezoko	430	13	1	1	CD
cord-316534-ep7ezoko	430	14	A	a	DT
cord-316534-ep7ezoko	430	15	potent	potent	JJ
cord-316534-ep7ezoko	430	16	cross	cross	NN
cord-316534-ep7ezoko	430	17	-	-	JJ
cord-316534-ep7ezoko	430	18	clade	clade	JJ
cord-316534-ep7ezoko	430	19	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	430	20	human	human	JJ
cord-316534-ep7ezoko	430	21	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	430	22	antibody	antibody	NN
cord-316534-ep7ezoko	430	23	against	against	IN
cord-316534-ep7ezoko	430	24	a	a	DT
cord-316534-ep7ezoko	430	25	novel	novel	JJ
cord-316534-ep7ezoko	430	26	epitope	epitope	NN
cord-316534-ep7ezoko	430	27	on	on	IN
cord-316534-ep7ezoko	430	28	gp41	gp41	NNP
cord-316534-ep7ezoko	430	29	of	of	IN
cord-316534-ep7ezoko	430	30	human	human	JJ
cord-316534-ep7ezoko	430	31	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	430	32	virus	virus	NN
cord-316534-ep7ezoko	430	33	type	type	NN
cord-316534-ep7ezoko	430	34	1	1	CD
cord-316534-ep7ezoko	430	35	Cross	Cross	NNP
cord-316534-ep7ezoko	430	36	-	-	HYPH
cord-316534-ep7ezoko	430	37	clade	clade	JJ
cord-316534-ep7ezoko	430	38	neutralization	neutralization	NN
cord-316534-ep7ezoko	430	39	of	of	IN
cord-316534-ep7ezoko	430	40	primary	primary	JJ
cord-316534-ep7ezoko	430	41	isolates	isolate	NNS
cord-316534-ep7ezoko	430	42	of	of	IN
cord-316534-ep7ezoko	430	43	human	human	JJ
cord-316534-ep7ezoko	430	44	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	430	45	virus	virus	NN
cord-316534-ep7ezoko	430	46	type	type	NN
cord-316534-ep7ezoko	430	47	1	1	CD
cord-316534-ep7ezoko	430	48	by	by	IN
cord-316534-ep7ezoko	430	49	human	human	JJ
cord-316534-ep7ezoko	430	50	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	430	51	antibodies	antibody	NNS
cord-316534-ep7ezoko	430	52	and	and	CC
cord-316534-ep7ezoko	430	53	tetrameric	tetrameric	JJ
cord-316534-ep7ezoko	430	54	CD4-IgG	cd4-igg	CD
cord-316534-ep7ezoko	430	55	sCD4	scd4	NN
cord-316534-ep7ezoko	430	56	-	-	HYPH
cord-316534-ep7ezoko	430	57	17b	17b	NNS
cord-316534-ep7ezoko	430	58	bifunctional	bifunctional	JJ
cord-316534-ep7ezoko	430	59	protein	protein	NN
cord-316534-ep7ezoko	430	60	:	:	:
cord-316534-ep7ezoko	430	61	extremely	extremely	RB
cord-316534-ep7ezoko	430	62	broad	broad	JJ
cord-316534-ep7ezoko	430	63	and	and	CC
cord-316534-ep7ezoko	430	64	potent	potent	JJ
cord-316534-ep7ezoko	430	65	neutralization	neutralization	NN
cord-316534-ep7ezoko	430	66	of	of	IN
cord-316534-ep7ezoko	430	67	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	430	68	Env	Env	NNP
cord-316534-ep7ezoko	430	69	pseudotyped	pseudotype	VBZ
cord-316534-ep7ezoko	430	70	viruses	virus	NNS
cord-316534-ep7ezoko	430	71	from	from	IN
cord-316534-ep7ezoko	430	72	genetically	genetically	RB
cord-316534-ep7ezoko	430	73	diverse	diverse	JJ
cord-316534-ep7ezoko	430	74	primary	primary	JJ
cord-316534-ep7ezoko	430	75	isolates	isolate	NNS
cord-316534-ep7ezoko	430	76	Analysis	Analysis	NNP
cord-316534-ep7ezoko	430	77	of	of	IN
cord-316534-ep7ezoko	430	78	memory	memory	NN
cord-316534-ep7ezoko	430	79	B	b	NN
cord-316534-ep7ezoko	430	80	cell	cell	NN
cord-316534-ep7ezoko	430	81	responses	response	NNS
cord-316534-ep7ezoko	430	82	and	and	CC
cord-316534-ep7ezoko	430	83	isolation	isolation	NN
cord-316534-ep7ezoko	430	84	of	of	IN
cord-316534-ep7ezoko	430	85	novel	novel	JJ
cord-316534-ep7ezoko	430	86	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	430	87	antibodies	antibody	NNS
cord-316534-ep7ezoko	430	88	with	with	IN
cord-316534-ep7ezoko	430	89	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	430	90	breadth	breadth	NN
cord-316534-ep7ezoko	430	91	from	from	IN
cord-316534-ep7ezoko	430	92	HIV-1-infected	hiv-1-infecte	VBN
cord-316534-ep7ezoko	430	93	individuals	individual	NNS
cord-316534-ep7ezoko	430	94	Long	long	JJ
cord-316534-ep7ezoko	430	95	-	-	HYPH
cord-316534-ep7ezoko	430	96	term	term	NN
cord-316534-ep7ezoko	430	97	nonprogression	nonprogression	NN
cord-316534-ep7ezoko	430	98	in	in	IN
cord-316534-ep7ezoko	430	99	HIV	HIV	NNP
cord-316534-ep7ezoko	430	100	infection	infection	NN
cord-316534-ep7ezoko	430	101	:	:	:
cord-316534-ep7ezoko	430	102	methodological	methodological	JJ
cord-316534-ep7ezoko	430	103	issues	issue	NNS
cord-316534-ep7ezoko	430	104	and	and	CC
cord-316534-ep7ezoko	430	105	scientific	scientific	JJ
cord-316534-ep7ezoko	430	106	priorities	priority	NNS
cord-316534-ep7ezoko	431	1	The	the	DT
cord-316534-ep7ezoko	431	2	immunology	immunology	NN
cord-316534-ep7ezoko	431	3	of	of	IN
cord-316534-ep7ezoko	431	4	HIV	HIV	NNP
cord-316534-ep7ezoko	431	5	-	-	HYPH
cord-316534-ep7ezoko	431	6	infected	infect	VBN
cord-316534-ep7ezoko	431	7	long	long	JJ
cord-316534-ep7ezoko	431	8	-	-	HYPH
cord-316534-ep7ezoko	431	9	term	term	NN
cord-316534-ep7ezoko	431	10	nonprogressors	nonprogressor	NNS
cord-316534-ep7ezoko	431	11	-	-	:
cord-316534-ep7ezoko	431	12	a	a	DT
cord-316534-ep7ezoko	431	13	current	current	JJ
cord-316534-ep7ezoko	431	14	view	view	NN
cord-316534-ep7ezoko	431	15	Long	long	JJ
cord-316534-ep7ezoko	431	16	-	-	HYPH
cord-316534-ep7ezoko	431	17	term	term	NN
cord-316534-ep7ezoko	431	18	observations	observation	NNS
cord-316534-ep7ezoko	431	19	of	of	IN
cord-316534-ep7ezoko	431	20	human	human	JJ
cord-316534-ep7ezoko	431	21	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	431	22	virus	virus	NN
cord-316534-ep7ezoko	431	23	-	-	HYPH
cord-316534-ep7ezoko	431	24	infected	infect	VBN
cord-316534-ep7ezoko	431	25	chimpanzees	chimpanzee	NNS
cord-316534-ep7ezoko	431	26	Simian	simian	JJ
cord-316534-ep7ezoko	431	27	and	and	CC
cord-316534-ep7ezoko	431	28	feline	feline	JJ
cord-316534-ep7ezoko	431	29	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	431	30	viruses	virus	NNS
cord-316534-ep7ezoko	431	31	:	:	:
cord-316534-ep7ezoko	431	32	animal	animal	NN
cord-316534-ep7ezoko	431	33	lentivirus	lentivirus	NN
cord-316534-ep7ezoko	431	34	models	model	NNS
cord-316534-ep7ezoko	431	35	for	for	IN
cord-316534-ep7ezoko	431	36	evaluation	evaluation	NN
cord-316534-ep7ezoko	431	37	of	of	IN
cord-316534-ep7ezoko	431	38	AIDS	AIDS	NNP
cord-316534-ep7ezoko	431	39	vaccines	vaccine	NNS
cord-316534-ep7ezoko	431	40	and	and	CC
cord-316534-ep7ezoko	431	41	antiviral	antiviral	JJ
cord-316534-ep7ezoko	431	42	agents	agent	NNS
cord-316534-ep7ezoko	432	1	The	the	DT
cord-316534-ep7ezoko	432	2	feline	feline	JJ
cord-316534-ep7ezoko	432	3	model	model	NN
cord-316534-ep7ezoko	432	4	of	of	IN
cord-316534-ep7ezoko	432	5	neuroAIDS	neuroAIDS	NNP
cord-316534-ep7ezoko	432	6	:	:	:
cord-316534-ep7ezoko	432	7	understanding	understand	VBG
cord-316534-ep7ezoko	432	8	the	the	DT
cord-316534-ep7ezoko	432	9	progression	progression	NN
cord-316534-ep7ezoko	432	10	towards	towards	IN
cord-316534-ep7ezoko	432	11	AIDS	AIDS	NNP
cord-316534-ep7ezoko	432	12	dementia	dementia	NN
cord-316534-ep7ezoko	432	13	Feline	feline	JJ
cord-316534-ep7ezoko	432	14	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	432	15	virus	virus	NN
cord-316534-ep7ezoko	432	16	model	model	NN
cord-316534-ep7ezoko	432	17	for	for	IN
cord-316534-ep7ezoko	432	18	designing	design	VBG
cord-316534-ep7ezoko	432	19	HIV	HIV	NNP
cord-316534-ep7ezoko	432	20	/	/	SYM
cord-316534-ep7ezoko	432	21	AIDS	AIDS	NNP
cord-316534-ep7ezoko	432	22	vaccines	vaccine	VBZ
cord-316534-ep7ezoko	432	23	Human	human	JJ
cord-316534-ep7ezoko	432	24	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	432	25	virus	virus	NN
cord-316534-ep7ezoko	432	26	infection	infection	NN
cord-316534-ep7ezoko	432	27	of	of	IN
cord-316534-ep7ezoko	432	28	human	human	JJ
cord-316534-ep7ezoko	432	29	-	-	HYPH
cord-316534-ep7ezoko	432	30	PBL	pbl	JJ
cord-316534-ep7ezoko	432	31	-	-	HYPH
cord-316534-ep7ezoko	432	32	SCID	SCID	NNP
cord-316534-ep7ezoko	432	33	mice	mouse	NNS
cord-316534-ep7ezoko	432	34	Suppression	Suppression	NNP
cord-316534-ep7ezoko	432	35	of	of	IN
cord-316534-ep7ezoko	432	36	HIV	HIV	NNP
cord-316534-ep7ezoko	432	37	infection	infection	NN
cord-316534-ep7ezoko	432	38	in	in	IN
cord-316534-ep7ezoko	432	39	AZT	AZT	NNP
cord-316534-ep7ezoko	432	40	-	-	HYPH
cord-316534-ep7ezoko	432	41	treated	treat	VBN
cord-316534-ep7ezoko	432	42	SCID	SCID	NNP
cord-316534-ep7ezoko	432	43	-	-	HYPH
cord-316534-ep7ezoko	432	44	hu	hu	NNP
cord-316534-ep7ezoko	432	45	mice	mouse	NNS
cord-316534-ep7ezoko	432	46	Disseminated	disseminate	VBN
cord-316534-ep7ezoko	432	47	and	and	CC
cord-316534-ep7ezoko	432	48	sustained	sustain	VBD
cord-316534-ep7ezoko	432	49	HIV	HIV	NNP
cord-316534-ep7ezoko	432	50	infection	infection	NN
cord-316534-ep7ezoko	432	51	in	in	IN
cord-316534-ep7ezoko	432	52	CD34	CD34	NNP
cord-316534-ep7ezoko	432	53	+	+	CC
cord-316534-ep7ezoko	433	1	cord	cord	NN
cord-316534-ep7ezoko	433	2	blood	blood	NN
cord-316534-ep7ezoko	434	1	cell	cell	NN
cord-316534-ep7ezoko	434	2	-	-	HYPH
cord-316534-ep7ezoko	434	3	transplanted	transplant	VBN
cord-316534-ep7ezoko	434	4	Rag2-/-gamma	Rag2-/-gamma	NNP
cord-316534-ep7ezoko	434	5	c-/-mice	c-/-mice	.
cord-316534-ep7ezoko	435	1	Animal	animal	NN
cord-316534-ep7ezoko	435	2	models	model	NNS
cord-316534-ep7ezoko	435	3	of	of	IN
cord-316534-ep7ezoko	435	4	AIDS	AIDS	NNP
cord-316534-ep7ezoko	435	5	Infection	Infection	NNP
cord-316534-ep7ezoko	435	6	of	of	IN
cord-316534-ep7ezoko	435	7	cynomolgus	cynomolgus	JJ
cord-316534-ep7ezoko	435	8	monkeys	monkey	NNS
cord-316534-ep7ezoko	435	9	with	with	IN
cord-316534-ep7ezoko	435	10	a	a	DT
cord-316534-ep7ezoko	435	11	chimeric	chimeric	JJ
cord-316534-ep7ezoko	435	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	435	13	/	/	SYM
cord-316534-ep7ezoko	435	14	SIVmac	SIVmac	NNP
cord-316534-ep7ezoko	435	15	virus	virus	NN
cord-316534-ep7ezoko	435	16	that	that	WDT
cord-316534-ep7ezoko	435	17	expresses	express	VBZ
cord-316534-ep7ezoko	435	18	the	the	DT
cord-316534-ep7ezoko	435	19	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	435	20	envelope	envelope	NN
cord-316534-ep7ezoko	435	21	glycoproteins	glycoprotein	VBZ
cord-316534-ep7ezoko	435	22	A	a	DT
cord-316534-ep7ezoko	435	23	chimeric	chimeric	JJ
cord-316534-ep7ezoko	435	24	simian	simian	JJ
cord-316534-ep7ezoko	435	25	/	/	SYM
cord-316534-ep7ezoko	435	26	human	human	JJ
cord-316534-ep7ezoko	435	27	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	435	28	virus	virus	NN
cord-316534-ep7ezoko	435	29	expressing	express	VBG
cord-316534-ep7ezoko	435	30	a	a	DT
cord-316534-ep7ezoko	435	31	primary	primary	JJ
cord-316534-ep7ezoko	435	32	patient	patient	JJ
cord-316534-ep7ezoko	435	33	human	human	JJ
cord-316534-ep7ezoko	435	34	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	435	35	virus	virus	NN
cord-316534-ep7ezoko	435	36	type	type	NN
cord-316534-ep7ezoko	435	37	1	1	CD
cord-316534-ep7ezoko	435	38	isolate	isolate	VBP
cord-316534-ep7ezoko	435	39	env	env	NN
cord-316534-ep7ezoko	435	40	causes	cause	VBZ
cord-316534-ep7ezoko	435	41	an	an	DT
cord-316534-ep7ezoko	435	42	AIDS	AIDS	NNP
cord-316534-ep7ezoko	435	43	-	-	HYPH
cord-316534-ep7ezoko	435	44	like	like	JJ
cord-316534-ep7ezoko	435	45	disease	disease	NN
cord-316534-ep7ezoko	435	46	after	after	IN
cord-316534-ep7ezoko	435	47	in	in	IN
cord-316534-ep7ezoko	435	48	vivo	vivo	NN
cord-316534-ep7ezoko	435	49	passage	passage	NN
cord-316534-ep7ezoko	435	50	in	in	IN
cord-316534-ep7ezoko	435	51	rhesus	rhesu	NNS
cord-316534-ep7ezoko	435	52	monkeys	monkey	NNS
cord-316534-ep7ezoko	435	53	Highly	highly	RB
cord-316534-ep7ezoko	435	54	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	435	55	SHIVs	shiv	NNS
cord-316534-ep7ezoko	435	56	and	and	CC
cord-316534-ep7ezoko	435	57	SIVs	siv	NNS
cord-316534-ep7ezoko	435	58	target	target	VBP
cord-316534-ep7ezoko	435	59	different	different	JJ
cord-316534-ep7ezoko	435	60	CD4	CD4	NNP
cord-316534-ep7ezoko	435	61	+	+	CC
cord-316534-ep7ezoko	435	62	T	t	NN
cord-316534-ep7ezoko	435	63	cell	cell	NN
cord-316534-ep7ezoko	435	64	subsets	subset	NNS
cord-316534-ep7ezoko	435	65	in	in	IN
cord-316534-ep7ezoko	435	66	rhesus	rhesu	NNS
cord-316534-ep7ezoko	435	67	monkeys	monkey	NNS
cord-316534-ep7ezoko	435	68	,	,	,
cord-316534-ep7ezoko	435	69	explaining	explain	VBG
cord-316534-ep7ezoko	435	70	their	-PRON-	PRP$
cord-316534-ep7ezoko	435	71	divergent	divergent	JJ
cord-316534-ep7ezoko	435	72	clinical	clinical	JJ
cord-316534-ep7ezoko	435	73	courses	course	NNS
cord-316534-ep7ezoko	435	74	Efficacy	Efficacy	NNP
cord-316534-ep7ezoko	435	75	assessment	assessment	NN
cord-316534-ep7ezoko	435	76	of	of	IN
cord-316534-ep7ezoko	435	77	a	a	DT
cord-316534-ep7ezoko	435	78	cell	cell	NN
cord-316534-ep7ezoko	435	79	-	-	HYPH
cord-316534-ep7ezoko	435	80	mediated	mediate	VBN
cord-316534-ep7ezoko	435	81	immunity	immunity	NN
cord-316534-ep7ezoko	435	82	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	435	83	vaccine	vaccine	NN
cord-316534-ep7ezoko	435	84	(	(	-LRB-
cord-316534-ep7ezoko	435	85	the	the	DT
cord-316534-ep7ezoko	435	86	Step	Step	NNP
cord-316534-ep7ezoko	435	87	Study	Study	NNP
cord-316534-ep7ezoko	435	88	)	)	-RRB-
cord-316534-ep7ezoko	435	89	:	:	:
cord-316534-ep7ezoko	435	90	a	a	DT
cord-316534-ep7ezoko	435	91	doubleblind	doubleblind	NN
cord-316534-ep7ezoko	435	92	,	,	,
cord-316534-ep7ezoko	435	93	randomised	randomised	JJ
cord-316534-ep7ezoko	435	94	,	,	,
cord-316534-ep7ezoko	436	1	placebo	placebo	NN
cord-316534-ep7ezoko	436	2	-	-	HYPH
cord-316534-ep7ezoko	436	3	controlled	control	VBN
cord-316534-ep7ezoko	436	4	,	,	,
cord-316534-ep7ezoko	436	5	test	test	NN
cord-316534-ep7ezoko	436	6	-	-	HYPH
cord-316534-ep7ezoko	436	7	of	of	IN
cord-316534-ep7ezoko	436	8	-	-	HYPH
cord-316534-ep7ezoko	436	9	concept	concept	NN
cord-316534-ep7ezoko	436	10	trial	trial	NN
cord-316534-ep7ezoko	436	11	Replication	replication	NN
cord-316534-ep7ezoko	436	12	-	-	HYPH
cord-316534-ep7ezoko	436	13	incompetent	incompetent	JJ
cord-316534-ep7ezoko	436	14	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	436	15	vaccine	vaccine	NN
cord-316534-ep7ezoko	436	16	vector	vector	NN
cord-316534-ep7ezoko	436	17	elicits	elicit	VBZ
cord-316534-ep7ezoko	436	18	effective	effective	JJ
cord-316534-ep7ezoko	436	19	anti	anti	JJ
cord-316534-ep7ezoko	436	20	-	-	JJ
cord-316534-ep7ezoko	436	21	immunodeficiency	immunodeficiency	JJ
cord-316534-ep7ezoko	436	22	-	-	HYPH
cord-316534-ep7ezoko	436	23	virus	virus	NN
cord-316534-ep7ezoko	436	24	immunity	immunity	NN
cord-316534-ep7ezoko	436	25	Importance	importance	NN
cord-316534-ep7ezoko	436	26	of	of	IN
cord-316534-ep7ezoko	436	27	the	the	DT
cord-316534-ep7ezoko	436	28	nef	nef	NNP
cord-316534-ep7ezoko	436	29	gene	gene	NN
cord-316534-ep7ezoko	436	30	for	for	IN
cord-316534-ep7ezoko	436	31	maintenance	maintenance	NN
cord-316534-ep7ezoko	436	32	of	of	IN
cord-316534-ep7ezoko	436	33	high	high	JJ
cord-316534-ep7ezoko	436	34	virus	virus	NN
cord-316534-ep7ezoko	436	35	loads	load	NNS
cord-316534-ep7ezoko	436	36	and	and	CC
cord-316534-ep7ezoko	436	37	for	for	IN
cord-316534-ep7ezoko	436	38	development	development	NN
cord-316534-ep7ezoko	436	39	of	of	IN
cord-316534-ep7ezoko	436	40	AIDS	AIDS	NNP
cord-316534-ep7ezoko	436	41	Protective	protective	JJ
cord-316534-ep7ezoko	436	42	effects	effect	NNS
cord-316534-ep7ezoko	436	43	of	of	IN
cord-316534-ep7ezoko	436	44	a	a	DT
cord-316534-ep7ezoko	436	45	live	live	JJ
cord-316534-ep7ezoko	436	46	attenuated	attenuate	VBN
cord-316534-ep7ezoko	436	47	SIV	SIV	NNP
cord-316534-ep7ezoko	436	48	vaccine	vaccine	NN
cord-316534-ep7ezoko	436	49	with	with	IN
cord-316534-ep7ezoko	436	50	a	a	DT
cord-316534-ep7ezoko	436	51	deletion	deletion	NN
cord-316534-ep7ezoko	436	52	in	in	IN
cord-316534-ep7ezoko	436	53	the	the	DT
cord-316534-ep7ezoko	436	54	nef	nef	NNP
cord-316534-ep7ezoko	436	55	gene	gene	NN
cord-316534-ep7ezoko	436	56	Molecular	Molecular	NNP
cord-316534-ep7ezoko	436	57	and	and	CC
cord-316534-ep7ezoko	436	58	biological	biological	JJ
cord-316534-ep7ezoko	436	59	characterization	characterization	NN
cord-316534-ep7ezoko	436	60	of	of	IN
cord-316534-ep7ezoko	436	61	simian	simian	JJ
cord-316534-ep7ezoko	436	62	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	436	63	virus	virus	NN
cord-316534-ep7ezoko	436	64	macaque	macaque	NN
cord-316534-ep7ezoko	436	65	strain	strain	NN
cord-316534-ep7ezoko	436	66	32H	32H	NNP
cord-316534-ep7ezoko	436	67	proviral	proviral	JJ
cord-316534-ep7ezoko	436	68	clones	clone	NNS
cord-316534-ep7ezoko	436	69	containing	contain	VBG
cord-316534-ep7ezoko	436	70	nef	nef	NNP
cord-316534-ep7ezoko	436	71	size	size	NN
cord-316534-ep7ezoko	436	72	variants	variant	NNS
cord-316534-ep7ezoko	436	73	Macaques	macaque	NNS
cord-316534-ep7ezoko	436	74	infected	infect	VBN
cord-316534-ep7ezoko	436	75	with	with	IN
cord-316534-ep7ezoko	436	76	live	live	JJ
cord-316534-ep7ezoko	436	77	attenuated	attenuated	JJ
cord-316534-ep7ezoko	436	78	SIVmac	SIVmac	NNP
cord-316534-ep7ezoko	436	79	are	be	VBP
cord-316534-ep7ezoko	436	80	protected	protect	VBN
cord-316534-ep7ezoko	436	81	against	against	IN
cord-316534-ep7ezoko	436	82	superinfection	superinfection	NN
cord-316534-ep7ezoko	436	83	via	via	IN
cord-316534-ep7ezoko	436	84	the	the	DT
cord-316534-ep7ezoko	436	85	rectal	rectal	JJ
cord-316534-ep7ezoko	436	86	mucosa	mucosa	NN
cord-316534-ep7ezoko	436	87	Immunization	immunization	NN
cord-316534-ep7ezoko	436	88	with	with	IN
cord-316534-ep7ezoko	436	89	a	a	DT
cord-316534-ep7ezoko	436	90	live	live	JJ
cord-316534-ep7ezoko	436	91	,	,	,
cord-316534-ep7ezoko	436	92	attenuated	attenuated	JJ
cord-316534-ep7ezoko	436	93	simian	simian	JJ
cord-316534-ep7ezoko	436	94	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	436	95	virus	virus	NN
cord-316534-ep7ezoko	436	96	(	(	-LRB-
cord-316534-ep7ezoko	436	97	SIV	SIV	NNP
cord-316534-ep7ezoko	436	98	)	)	-RRB-
cord-316534-ep7ezoko	436	99	prevents	prevent	VBZ
cord-316534-ep7ezoko	436	100	early	early	JJ
cord-316534-ep7ezoko	436	101	disease	disease	NN
cord-316534-ep7ezoko	436	102	but	but	CC
cord-316534-ep7ezoko	437	1	not	not	RB
cord-316534-ep7ezoko	437	2	infection	infection	NN
cord-316534-ep7ezoko	437	3	in	in	IN
cord-316534-ep7ezoko	437	4	rhesus	rhesu	NNS
cord-316534-ep7ezoko	437	5	macaques	macaque	NNS
cord-316534-ep7ezoko	437	6	challenged	challenge	VBN
cord-316534-ep7ezoko	437	7	with	with	IN
cord-316534-ep7ezoko	437	8	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	437	9	SIV	SIV	NNP
cord-316534-ep7ezoko	437	10	Live	Live	NNP
cord-316534-ep7ezoko	437	11	,	,	,
cord-316534-ep7ezoko	437	12	attenuated	attenuated	JJ
cord-316534-ep7ezoko	437	13	simian	simian	JJ
cord-316534-ep7ezoko	437	14	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	437	15	virus	virus	NN
cord-316534-ep7ezoko	437	16	SIVmac	SIVmac	NNP
cord-316534-ep7ezoko	437	17	-	-	HYPH
cord-316534-ep7ezoko	437	18	M4	M4	NNP
cord-316534-ep7ezoko	437	19	,	,	,
cord-316534-ep7ezoko	437	20	with	with	IN
cord-316534-ep7ezoko	437	21	point	point	NN
cord-316534-ep7ezoko	437	22	mutations	mutation	NNS
cord-316534-ep7ezoko	437	23	in	in	IN
cord-316534-ep7ezoko	437	24	the	the	DT
cord-316534-ep7ezoko	437	25	Env	Env	NNP
cord-316534-ep7ezoko	437	26	transmembrane	transmembrane	NN
cord-316534-ep7ezoko	437	27	protein	protein	NN
cord-316534-ep7ezoko	437	28	intracytoplasmic	intracytoplasmic	JJ
cord-316534-ep7ezoko	437	29	domain	domain	NN
cord-316534-ep7ezoko	437	30	,	,	,
cord-316534-ep7ezoko	437	31	provides	provide	VBZ
cord-316534-ep7ezoko	437	32	partial	partial	JJ
cord-316534-ep7ezoko	437	33	protection	protection	NN
cord-316534-ep7ezoko	437	34	from	from	IN
cord-316534-ep7ezoko	437	35	mucosal	mucosal	JJ
cord-316534-ep7ezoko	437	36	challenge	challenge	NN
cord-316534-ep7ezoko	437	37	with	with	IN
cord-316534-ep7ezoko	437	38	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	437	39	SIVmac251	SIVmac251	NNP
cord-316534-ep7ezoko	437	40	Protection	Protection	NNP
cord-316534-ep7ezoko	437	41	of	of	IN
cord-316534-ep7ezoko	437	42	macaques	macaque	NNS
cord-316534-ep7ezoko	437	43	against	against	IN
cord-316534-ep7ezoko	437	44	simian	simian	JJ
cord-316534-ep7ezoko	437	45	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	437	46	virus	virus	NN
cord-316534-ep7ezoko	437	47	infection	infection	NN
cord-316534-ep7ezoko	437	48	with	with	IN
cord-316534-ep7ezoko	437	49	inactivated	inactivate	VBN
cord-316534-ep7ezoko	437	50	vaccines	vaccine	NNS
cord-316534-ep7ezoko	437	51	:	:	:
cord-316534-ep7ezoko	437	52	comparison	comparison	NN
cord-316534-ep7ezoko	437	53	of	of	IN
cord-316534-ep7ezoko	437	54	adjuvants	adjuvant	NNS
cord-316534-ep7ezoko	437	55	,	,	,
cord-316534-ep7ezoko	437	56	doses	dose	NNS
cord-316534-ep7ezoko	437	57	and	and	CC
cord-316534-ep7ezoko	437	58	challenge	challenge	NN
cord-316534-ep7ezoko	437	59	viruses	virus	NNS
cord-316534-ep7ezoko	437	60	.	.	.
cord-316534-ep7ezoko	438	1	The	the	DT
cord-316534-ep7ezoko	438	2	European	European	NNP
cord-316534-ep7ezoko	438	3	Concerted	Concerted	NNP
cord-316534-ep7ezoko	438	4	Action	Action	NNP
cord-316534-ep7ezoko	438	5	on	on	IN
cord-316534-ep7ezoko	438	6	'	'	``
cord-316534-ep7ezoko	438	7	Macaque	Macaque	NNP
cord-316534-ep7ezoko	438	8	Models	Models	NNPS
cord-316534-ep7ezoko	438	9	for	for	IN
cord-316534-ep7ezoko	438	10	AIDS	AIDS	NNP
cord-316534-ep7ezoko	438	11	Research	Research	NNP
cord-316534-ep7ezoko	438	12	'	'	''
cord-316534-ep7ezoko	438	13	Whole	Whole	NNP
cord-316534-ep7ezoko	438	14	inactivated	inactivate	VBD
cord-316534-ep7ezoko	438	15	SIV	SIV	NNP
cord-316534-ep7ezoko	438	16	vaccine	vaccine	NN
cord-316534-ep7ezoko	438	17	grown	grow	VBN
cord-316534-ep7ezoko	438	18	on	on	IN
cord-316534-ep7ezoko	438	19	human	human	JJ
cord-316534-ep7ezoko	438	20	cells	cell	NNS
cord-316534-ep7ezoko	438	21	fails	fail	VBZ
cord-316534-ep7ezoko	438	22	to	to	TO
cord-316534-ep7ezoko	438	23	protect	protect	VB
cord-316534-ep7ezoko	438	24	against	against	IN
cord-316534-ep7ezoko	438	25	homologous	homologous	JJ
cord-316534-ep7ezoko	438	26	SIV	SIV	NNP
cord-316534-ep7ezoko	438	27	grown	grow	VBN
cord-316534-ep7ezoko	438	28	on	on	IN
cord-316534-ep7ezoko	438	29	simian	simian	JJ
cord-316534-ep7ezoko	438	30	cells	cell	NNS
cord-316534-ep7ezoko	438	31	Protection	Protection	NNP
cord-316534-ep7ezoko	438	32	of	of	IN
cord-316534-ep7ezoko	438	33	monkeys	monkey	NNS
cord-316534-ep7ezoko	438	34	by	by	IN
cord-316534-ep7ezoko	438	35	a	a	DT
cord-316534-ep7ezoko	438	36	split	split	JJ
cord-316534-ep7ezoko	438	37	vaccine	vaccine	NN
cord-316534-ep7ezoko	438	38	against	against	IN
cord-316534-ep7ezoko	438	39	SIVmac	SIVmac	NNP
cord-316534-ep7ezoko	439	1	depends	depend	VBZ
cord-316534-ep7ezoko	439	2	upon	upon	IN
cord-316534-ep7ezoko	439	3	biological	biological	JJ
cord-316534-ep7ezoko	439	4	properties	property	NNS
cord-316534-ep7ezoko	439	5	of	of	IN
cord-316534-ep7ezoko	439	6	the	the	DT
cord-316534-ep7ezoko	439	7	challenge	challenge	NN
cord-316534-ep7ezoko	439	8	virus	virus	NN
cord-316534-ep7ezoko	439	9	Dual	dual	JJ
cord-316534-ep7ezoko	439	10	-	-	HYPH
cord-316534-ep7ezoko	439	11	subtype	subtype	NN
cord-316534-ep7ezoko	439	12	vaccine	vaccine	NN
cord-316534-ep7ezoko	439	13	(	(	-LRB-
cord-316534-ep7ezoko	439	14	Fel	Fel	NNP
cord-316534-ep7ezoko	439	15	-	-	HYPH
cord-316534-ep7ezoko	439	16	O	O	NNP
cord-316534-ep7ezoko	439	17	-	-	HYPH
cord-316534-ep7ezoko	439	18	Vax	Vax	NNP
cord-316534-ep7ezoko	439	19	FIV	FIV	NNP
cord-316534-ep7ezoko	439	20	)	)	-RRB-
cord-316534-ep7ezoko	439	21	protects	protect	VBZ
cord-316534-ep7ezoko	439	22	cats	cat	NNS
cord-316534-ep7ezoko	439	23	against	against	IN
cord-316534-ep7ezoko	439	24	contact	contact	NN
cord-316534-ep7ezoko	439	25	challenge	challenge	NN
cord-316534-ep7ezoko	439	26	with	with	IN
cord-316534-ep7ezoko	439	27	heterologous	heterologous	JJ
cord-316534-ep7ezoko	439	28	subtype	subtype	NN
cord-316534-ep7ezoko	439	29	B	B	NNP
cord-316534-ep7ezoko	439	30	FIV	FIV	NNP
cord-316534-ep7ezoko	439	31	infected	infected	JJ
cord-316534-ep7ezoko	439	32	cats	cat	NNS
cord-316534-ep7ezoko	440	1	Dual	dual	JJ
cord-316534-ep7ezoko	440	2	-	-	HYPH
cord-316534-ep7ezoko	440	3	subtype	subtype	NN
cord-316534-ep7ezoko	440	4	FIV	fiv	NN
cord-316534-ep7ezoko	440	5	vaccine	vaccine	NN
cord-316534-ep7ezoko	440	6	protects	protect	VBZ
cord-316534-ep7ezoko	440	7	cats	cat	NNS
cord-316534-ep7ezoko	440	8	against	against	IN
cord-316534-ep7ezoko	440	9	in	in	IN
cord-316534-ep7ezoko	440	10	vivo	vivo	NN
cord-316534-ep7ezoko	440	11	swarms	swarm	NNS
cord-316534-ep7ezoko	440	12	of	of	IN
cord-316534-ep7ezoko	440	13	both	both	DT
cord-316534-ep7ezoko	441	1	homologous	homologous	JJ
cord-316534-ep7ezoko	441	2	and	and	CC
cord-316534-ep7ezoko	441	3	heterologous	heterologous	JJ
cord-316534-ep7ezoko	441	4	subtype	subtype	NN
cord-316534-ep7ezoko	441	5	FIV	FIV	NNP
cord-316534-ep7ezoko	441	6	isolates	isolate	NNS
cord-316534-ep7ezoko	441	7	Effect	effect	NN
cord-316534-ep7ezoko	441	8	of	of	IN
cord-316534-ep7ezoko	441	9	dual	dual	JJ
cord-316534-ep7ezoko	441	10	-	-	HYPH
cord-316534-ep7ezoko	441	11	subtype	subtype	NN
cord-316534-ep7ezoko	441	12	vaccine	vaccine	NN
cord-316534-ep7ezoko	441	13	against	against	IN
cord-316534-ep7ezoko	441	14	feline	feline	JJ
cord-316534-ep7ezoko	441	15	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	441	16	virus	virus	NN
cord-316534-ep7ezoko	441	17	infection	infection	NN
cord-316534-ep7ezoko	442	1	Dual	dual	JJ
cord-316534-ep7ezoko	442	2	-	-	HYPH
cord-316534-ep7ezoko	442	3	subtype	subtype	NN
cord-316534-ep7ezoko	442	4	FIV	fiv	NN
cord-316534-ep7ezoko	442	5	vaccine	vaccine	NN
cord-316534-ep7ezoko	442	6	(	(	-LRB-
cord-316534-ep7ezoko	442	7	Fel	Fel	NNP
cord-316534-ep7ezoko	442	8	-	-	HYPH
cord-316534-ep7ezoko	442	9	O	O	NNP
cord-316534-ep7ezoko	442	10	-	-	HYPH
cord-316534-ep7ezoko	442	11	Vax	Vax	NNP
cord-316534-ep7ezoko	442	12	FIV	FIV	NNP
cord-316534-ep7ezoko	442	13	)	)	-RRB-
cord-316534-ep7ezoko	442	14	protection	protection	NN
cord-316534-ep7ezoko	442	15	against	against	IN
cord-316534-ep7ezoko	442	16	a	a	DT
cord-316534-ep7ezoko	442	17	heterologous	heterologous	JJ
cord-316534-ep7ezoko	442	18	subtype	subtype	NN
cord-316534-ep7ezoko	442	19	B	B	NNP
cord-316534-ep7ezoko	442	20	FIV	FIV	NNP
cord-316534-ep7ezoko	442	21	isolate	isolate	VB
cord-316534-ep7ezoko	442	22	Efficacy	Efficacy	NNP
cord-316534-ep7ezoko	442	23	testing	testing	NN
cord-316534-ep7ezoko	442	24	of	of	IN
cord-316534-ep7ezoko	442	25	recombinant	recombinant	JJ
cord-316534-ep7ezoko	442	26	human	human	JJ
cord-316534-ep7ezoko	442	27	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	442	28	virus	virus	NN
cord-316534-ep7ezoko	442	29	(	(	-LRB-
cord-316534-ep7ezoko	442	30	HIV	HIV	NNP
cord-316534-ep7ezoko	442	31	)	)	-RRB-
cord-316534-ep7ezoko	442	32	gp160	gp160	NNP
cord-316534-ep7ezoko	442	33	as	as	IN
cord-316534-ep7ezoko	442	34	a	a	DT
cord-316534-ep7ezoko	442	35	therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	442	36	vaccine	vaccine	NN
cord-316534-ep7ezoko	442	37	in	in	IN
cord-316534-ep7ezoko	442	38	early	early	JJ
cord-316534-ep7ezoko	442	39	-	-	HYPH
cord-316534-ep7ezoko	442	40	stage	stage	NN
cord-316534-ep7ezoko	442	41	HIV-1-infected	hiv-1-infecte	VBN
cord-316534-ep7ezoko	442	42	volunteers	volunteer	NNS
cord-316534-ep7ezoko	442	43	.	.	.
cord-316534-ep7ezoko	443	1	rgp160	rgp160	NNP
cord-316534-ep7ezoko	443	2	hase	hase	NNP
cord-316534-ep7ezoko	444	1	II	II	NNP
cord-316534-ep7ezoko	444	2	Vaccine	Vaccine	NNP
cord-316534-ep7ezoko	444	3	Investigators	Investigators	NNP
cord-316534-ep7ezoko	444	4	Randomised	randomised	JJ
cord-316534-ep7ezoko	444	5	trial	trial	NN
cord-316534-ep7ezoko	444	6	of	of	IN
cord-316534-ep7ezoko	444	7	MNrgp120	MNrgp120	NNP
cord-316534-ep7ezoko	444	8	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	444	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	444	10	in	in	IN
cord-316534-ep7ezoko	444	11	symptomless	symptomless	JJ
cord-316534-ep7ezoko	444	12	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	444	13	infection	infection	NN
cord-316534-ep7ezoko	444	14	Phase	Phase	NNP
cord-316534-ep7ezoko	444	15	II	II	NNP
cord-316534-ep7ezoko	444	16	controlled	control	VBN
cord-316534-ep7ezoko	444	17	trial	trial	NN
cord-316534-ep7ezoko	444	18	of	of	IN
cord-316534-ep7ezoko	444	19	post	post	JJ
cord-316534-ep7ezoko	444	20	-	-	JJ
cord-316534-ep7ezoko	444	21	exposure	exposure	JJ
cord-316534-ep7ezoko	444	22	immunization	immunization	NN
cord-316534-ep7ezoko	444	23	with	with	IN
cord-316534-ep7ezoko	444	24	recombinant	recombinant	JJ
cord-316534-ep7ezoko	444	25	gp160	gp160	NNP
cord-316534-ep7ezoko	444	26	versus	versus	IN
cord-316534-ep7ezoko	444	27	antiretroviral	antiretroviral	JJ
cord-316534-ep7ezoko	444	28	therapy	therapy	NN
cord-316534-ep7ezoko	444	29	in	in	IN
cord-316534-ep7ezoko	444	30	asymptomatic	asymptomatic	JJ
cord-316534-ep7ezoko	444	31	HIV-1-infected	hiv-1-infecte	VBN
cord-316534-ep7ezoko	444	32	adults	adult	NNS
cord-316534-ep7ezoko	444	33	.	.	.
cord-316534-ep7ezoko	445	1	VaxSyn	VaxSyn	NNP
cord-316534-ep7ezoko	445	2	Protocol	Protocol	NNP
cord-316534-ep7ezoko	445	3	Team	Team	NNP
cord-316534-ep7ezoko	445	4	Repeated	repeat	VBD
cord-316534-ep7ezoko	445	5	immunization	immunization	NN
cord-316534-ep7ezoko	445	6	with	with	IN
cord-316534-ep7ezoko	445	7	recombinant	recombinant	JJ
cord-316534-ep7ezoko	445	8	gp160	gp160	NNP
cord-316534-ep7ezoko	445	9	human	human	JJ
cord-316534-ep7ezoko	445	10	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	445	11	virus	virus	NN
cord-316534-ep7ezoko	445	12	(	(	-LRB-
cord-316534-ep7ezoko	445	13	HIV	HIV	NNP
cord-316534-ep7ezoko	445	14	)	)	-RRB-
cord-316534-ep7ezoko	445	15	envelope	envelope	NN
cord-316534-ep7ezoko	445	16	protein	protein	NN
cord-316534-ep7ezoko	445	17	in	in	IN
cord-316534-ep7ezoko	445	18	early	early	JJ
cord-316534-ep7ezoko	445	19	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	445	20	infection	infection	NN
cord-316534-ep7ezoko	445	21	:	:	:
cord-316534-ep7ezoko	445	22	evaluation	evaluation	NN
cord-316534-ep7ezoko	445	23	of	of	IN
cord-316534-ep7ezoko	445	24	the	the	DT
cord-316534-ep7ezoko	445	25	T	T	NNP
cord-316534-ep7ezoko	445	26	cell	cell	NN
cord-316534-ep7ezoko	445	27	proliferative	proliferative	JJ
cord-316534-ep7ezoko	445	28	response	response	NN
cord-316534-ep7ezoko	446	1	A	a	DT
cord-316534-ep7ezoko	446	2	phase	phase	NN
cord-316534-ep7ezoko	447	1	I	-PRON-	PRP
cord-316534-ep7ezoko	447	2	evaluation	evaluation	NN
cord-316534-ep7ezoko	447	3	of	of	IN
cord-316534-ep7ezoko	447	4	the	the	DT
cord-316534-ep7ezoko	447	5	safety	safety	NN
cord-316534-ep7ezoko	447	6	and	and	CC
cord-316534-ep7ezoko	447	7	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	447	8	of	of	IN
cord-316534-ep7ezoko	447	9	vaccination	vaccination	NN
cord-316534-ep7ezoko	447	10	with	with	IN
cord-316534-ep7ezoko	447	11	recombinant	recombinant	JJ
cord-316534-ep7ezoko	447	12	gp160	gp160	NNP
cord-316534-ep7ezoko	447	13	in	in	IN
cord-316534-ep7ezoko	447	14	patients	patient	NNS
cord-316534-ep7ezoko	447	15	with	with	IN
cord-316534-ep7ezoko	447	16	early	early	JJ
cord-316534-ep7ezoko	447	17	human	human	JJ
cord-316534-ep7ezoko	447	18	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	447	19	virus	virus	NN
cord-316534-ep7ezoko	447	20	infection	infection	NN
cord-316534-ep7ezoko	447	21	.	.	.
cord-316534-ep7ezoko	448	1	Military	Military	NNP
cord-316534-ep7ezoko	448	2	Medical	Medical	NNP
cord-316534-ep7ezoko	448	3	Consortium	Consortium	NNP
cord-316534-ep7ezoko	448	4	for	for	IN
cord-316534-ep7ezoko	449	1	Applied	Applied	NNP
cord-316534-ep7ezoko	449	2	Retroviral	Retroviral	NNP
cord-316534-ep7ezoko	449	3	Research	Research	NNP
cord-316534-ep7ezoko	449	4	Two	two	CD
cord-316534-ep7ezoko	449	5	double	double	RB
cord-316534-ep7ezoko	449	6	-	-	HYPH
cord-316534-ep7ezoko	449	7	blinded	blinded	JJ
cord-316534-ep7ezoko	449	8	,	,	,
cord-316534-ep7ezoko	449	9	randomized	randomized	JJ
cord-316534-ep7ezoko	449	10	,	,	,
cord-316534-ep7ezoko	449	11	comparative	comparative	JJ
cord-316534-ep7ezoko	449	12	trials	trial	NNS
cord-316534-ep7ezoko	449	13	of	of	IN
cord-316534-ep7ezoko	449	14	4	4	CD
cord-316534-ep7ezoko	449	15	human	human	JJ
cord-316534-ep7ezoko	449	16	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	449	17	virus	virus	NN
cord-316534-ep7ezoko	449	18	type	type	NN
cord-316534-ep7ezoko	449	19	1	1	CD
cord-316534-ep7ezoko	449	20	(	(	-LRB-
cord-316534-ep7ezoko	449	21	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	449	22	)	)	-RRB-
cord-316534-ep7ezoko	449	23	envelope	envelope	NN
cord-316534-ep7ezoko	449	24	vaccines	vaccine	NNS
cord-316534-ep7ezoko	449	25	in	in	IN
cord-316534-ep7ezoko	449	26	HIV-1-infected	hiv-1-infecte	VBN
cord-316534-ep7ezoko	449	27	individuals	individual	NNS
cord-316534-ep7ezoko	449	28	across	across	IN
cord-316534-ep7ezoko	449	29	a	a	DT
cord-316534-ep7ezoko	449	30	spectrum	spectrum	NN
cord-316534-ep7ezoko	449	31	of	of	IN
cord-316534-ep7ezoko	449	32	disease	disease	NN
cord-316534-ep7ezoko	449	33	severity	severity	NN
cord-316534-ep7ezoko	449	34	:	:	:
cord-316534-ep7ezoko	449	35	AIDS	AIDS	NNP
cord-316534-ep7ezoko	449	36	Clinical	Clinical	NNP
cord-316534-ep7ezoko	449	37	Trials	Trials	NNPS
cord-316534-ep7ezoko	449	38	Groups	Groups	NNPS
cord-316534-ep7ezoko	449	39	209	209	CD
cord-316534-ep7ezoko	449	40	a	a	DT
cord-316534-ep7ezoko	449	41	nd	nd	NNP
cord-316534-ep7ezoko	449	42	214	214	CD
cord-316534-ep7ezoko	450	1	A	a	DT
cord-316534-ep7ezoko	450	2	randomized	randomized	JJ
cord-316534-ep7ezoko	450	3	,	,	,
cord-316534-ep7ezoko	450	4	placebocontrolled	placebocontrolled	JJ
cord-316534-ep7ezoko	450	5	study	study	NN
cord-316534-ep7ezoko	450	6	of	of	IN
cord-316534-ep7ezoko	450	7	the	the	DT
cord-316534-ep7ezoko	450	8	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	450	9	of	of	IN
cord-316534-ep7ezoko	450	10	human	human	JJ
cord-316534-ep7ezoko	450	11	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	450	12	virus	virus	NN
cord-316534-ep7ezoko	450	13	(	(	-LRB-
cord-316534-ep7ezoko	450	14	HIV	HIV	NNP
cord-316534-ep7ezoko	450	15	)	)	-RRB-
cord-316534-ep7ezoko	451	1	rgp160	rgp160	NNP
cord-316534-ep7ezoko	451	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	451	3	in	in	IN
cord-316534-ep7ezoko	451	4	HIV	HIV	NNP
cord-316534-ep7ezoko	451	5	-	-	HYPH
cord-316534-ep7ezoko	451	6	infected	infect	VBN
cord-316534-ep7ezoko	451	7	subjects	subject	NNS
cord-316534-ep7ezoko	451	8	with	with	IN
cord-316534-ep7ezoko	451	9	.	.	.
cord-316534-ep7ezoko	452	1	or	or	CC
cord-316534-ep7ezoko	452	2	=	=	NFP
cord-316534-ep7ezoko	452	3	400/	400/	CD
cord-316534-ep7ezoko	453	1	mm3	mm3	NNS
cord-316534-ep7ezoko	453	2	CD4	CD4	NNP
cord-316534-ep7ezoko	453	3	T	T	NNP
cord-316534-ep7ezoko	453	4	lymphocytes	lymphocyte	NNS
cord-316534-ep7ezoko	453	5	Improved	improve	VBN
cord-316534-ep7ezoko	453	6	cell	cell	NN
cord-316534-ep7ezoko	453	7	-	-	HYPH
cord-316534-ep7ezoko	453	8	mediated	mediate	VBN
cord-316534-ep7ezoko	453	9	immune	immune	JJ
cord-316534-ep7ezoko	453	10	responses	response	NNS
cord-316534-ep7ezoko	453	11	in	in	IN
cord-316534-ep7ezoko	453	12	HIV-1-infected	hiv-1-infecte	VBN
cord-316534-ep7ezoko	453	13	asymptomatic	asymptomatic	JJ
cord-316534-ep7ezoko	453	14	individuals	individual	NNS
cord-316534-ep7ezoko	453	15	after	after	IN
cord-316534-ep7ezoko	453	16	immunization	immunization	NN
cord-316534-ep7ezoko	453	17	with	with	IN
cord-316534-ep7ezoko	453	18	envelope	envelope	NN
cord-316534-ep7ezoko	453	19	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	453	20	gp160	gp160	NNP
cord-316534-ep7ezoko	453	21	Immunization	Immunization	NNP
cord-316534-ep7ezoko	453	22	with	with	IN
cord-316534-ep7ezoko	453	23	envelope	envelope	NN
cord-316534-ep7ezoko	453	24	MN	MN	NNP
cord-316534-ep7ezoko	453	25	rgp120	rgp120	NNP
cord-316534-ep7ezoko	453	26	vaccine	vaccine	NN
cord-316534-ep7ezoko	453	27	in	in	IN
cord-316534-ep7ezoko	453	28	human	human	JJ
cord-316534-ep7ezoko	453	29	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	453	30	virus	virus	NN
cord-316534-ep7ezoko	453	31	-	-	HYPH
cord-316534-ep7ezoko	453	32	infected	infect	VBN
cord-316534-ep7ezoko	453	33	pregnant	pregnant	JJ
cord-316534-ep7ezoko	453	34	women	woman	NNS
cord-316534-ep7ezoko	453	35	Immunogenicity	Immunogenicity	NNP
cord-316534-ep7ezoko	453	36	of	of	IN
cord-316534-ep7ezoko	453	37	the	the	DT
cord-316534-ep7ezoko	453	38	yeast	yeast	NN
cord-316534-ep7ezoko	453	39	recombinant	recombinant	NN
cord-316534-ep7ezoko	453	40	p17	p17	NN
cord-316534-ep7ezoko	453	41	/	/	SYM
cord-316534-ep7ezoko	453	42	p24	p24	NN
cord-316534-ep7ezoko	453	43	:	:	:
cord-316534-ep7ezoko	454	1	Ty	ty	JJ
cord-316534-ep7ezoko	454	2	virus	virus	NN
cord-316534-ep7ezoko	454	3	-	-	HYPH
cord-316534-ep7ezoko	454	4	like	like	JJ
cord-316534-ep7ezoko	454	5	particles	particle	NNS
cord-316534-ep7ezoko	454	6	(	(	-LRB-
cord-316534-ep7ezoko	454	7	p24-VLP	p24-vlp	JJ
cord-316534-ep7ezoko	454	8	)	)	-RRB-
cord-316534-ep7ezoko	454	9	in	in	IN
cord-316534-ep7ezoko	454	10	healthy	healthy	JJ
cord-316534-ep7ezoko	454	11	volunteers	volunteer	NNS
cord-316534-ep7ezoko	454	12	Immunization	Immunization	NNP
cord-316534-ep7ezoko	454	13	with	with	IN
cord-316534-ep7ezoko	454	14	recombinant	recombinant	JJ
cord-316534-ep7ezoko	454	15	p17	p17	NN
cord-316534-ep7ezoko	454	16	/	/	SYM
cord-316534-ep7ezoko	454	17	p24	p24	NN
cord-316534-ep7ezoko	454	18	:	:	:
cord-316534-ep7ezoko	454	19	Ty	ty	JJ
cord-316534-ep7ezoko	454	20	virus	virus	NN
cord-316534-ep7ezoko	454	21	-	-	HYPH
cord-316534-ep7ezoko	454	22	like	like	JJ
cord-316534-ep7ezoko	454	23	particles	particle	NNS
cord-316534-ep7ezoko	454	24	in	in	IN
cord-316534-ep7ezoko	454	25	human	human	JJ
cord-316534-ep7ezoko	454	26	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	454	27	virus	virus	NN
cord-316534-ep7ezoko	454	28	-	-	HYPH
cord-316534-ep7ezoko	454	29	infected	infect	VBN
cord-316534-ep7ezoko	454	30	persons	person	NNS
cord-316534-ep7ezoko	454	31	Safety	safety	NN
cord-316534-ep7ezoko	454	32	and	and	CC
cord-316534-ep7ezoko	454	33	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	454	34	of	of	IN
cord-316534-ep7ezoko	454	35	a	a	DT
cord-316534-ep7ezoko	454	36	candidate	candidate	NN
cord-316534-ep7ezoko	454	37	therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	454	38	vaccine	vaccine	NN
cord-316534-ep7ezoko	454	39	,	,	,
cord-316534-ep7ezoko	454	40	p24	p24	NN
cord-316534-ep7ezoko	454	41	virus	virus	NN
cord-316534-ep7ezoko	454	42	-	-	HYPH
cord-316534-ep7ezoko	454	43	like	like	JJ
cord-316534-ep7ezoko	454	44	particle	particle	NN
cord-316534-ep7ezoko	454	45	,	,	,
cord-316534-ep7ezoko	454	46	combined	combine	VBN
cord-316534-ep7ezoko	454	47	with	with	IN
cord-316534-ep7ezoko	454	48	zidovudine	zidovudine	NN
cord-316534-ep7ezoko	454	49	,	,	,
cord-316534-ep7ezoko	454	50	in	in	IN
cord-316534-ep7ezoko	454	51	asymptomatic	asymptomatic	JJ
cord-316534-ep7ezoko	454	52	subjects	subject	NNS
cord-316534-ep7ezoko	455	1	Therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	455	2	vaccination	vaccination	NN
cord-316534-ep7ezoko	455	3	with	with	IN
cord-316534-ep7ezoko	455	4	p24-VLP	p24-vlp	JJ
cord-316534-ep7ezoko	455	5	and	and	CC
cord-316534-ep7ezoko	455	6	zidovudine	zidovudine	NN
cord-316534-ep7ezoko	455	7	augments	augment	VBZ
cord-316534-ep7ezoko	455	8	HIV	HIV	NNP
cord-316534-ep7ezoko	455	9	-	-	HYPH
cord-316534-ep7ezoko	455	10	specific	specific	JJ
cord-316534-ep7ezoko	455	11	cytotoxic	cytotoxic	JJ
cord-316534-ep7ezoko	455	12	T	t	NN
cord-316534-ep7ezoko	455	13	lymphocyte	lymphocyte	NN
cord-316534-ep7ezoko	455	14	activity	activity	NN
cord-316534-ep7ezoko	455	15	in	in	IN
cord-316534-ep7ezoko	455	16	asymptomatic	asymptomatic	JJ
cord-316534-ep7ezoko	455	17	HIV	HIV	NNP
cord-316534-ep7ezoko	455	18	-	-	HYPH
cord-316534-ep7ezoko	455	19	infected	infect	VBN
cord-316534-ep7ezoko	455	20	individuals	individual	NNS
cord-316534-ep7ezoko	455	21	Induction	Induction	NNP
cord-316534-ep7ezoko	455	22	of	of	IN
cord-316534-ep7ezoko	455	23	potent	potent	JJ
cord-316534-ep7ezoko	455	24	humoral	humoral	JJ
cord-316534-ep7ezoko	455	25	and	and	CC
cord-316534-ep7ezoko	455	26	cell	cell	NN
cord-316534-ep7ezoko	455	27	-	-	HYPH
cord-316534-ep7ezoko	455	28	mediated	mediate	VBN
cord-316534-ep7ezoko	455	29	immune	immune	JJ
cord-316534-ep7ezoko	455	30	responses	response	NNS
cord-316534-ep7ezoko	455	31	following	follow	VBG
cord-316534-ep7ezoko	455	32	direct	direct	JJ
cord-316534-ep7ezoko	455	33	injection	injection	NN
cord-316534-ep7ezoko	455	34	of	of	IN
cord-316534-ep7ezoko	455	35	DNA	dna	NN
cord-316534-ep7ezoko	455	36	encoding	encode	VBG
cord-316534-ep7ezoko	455	37	the	the	DT
cord-316534-ep7ezoko	455	38	HIV	HIV	NNP
cord-316534-ep7ezoko	455	39	type	type	NN
cord-316534-ep7ezoko	455	40	1	1	CD
cord-316534-ep7ezoko	455	41	env	env	NN
cord-316534-ep7ezoko	455	42	and	and	CC
cord-316534-ep7ezoko	455	43	rev	rev	NNP
cord-316534-ep7ezoko	455	44	gene	gene	NN
cord-316534-ep7ezoko	455	45	products	product	NNS
cord-316534-ep7ezoko	455	46	Retroviral	Retroviral	NNP
cord-316534-ep7ezoko	455	47	vectors	vector	NNS
cord-316534-ep7ezoko	455	48	for	for	IN
cord-316534-ep7ezoko	455	49	vaccine	vaccine	NN
cord-316534-ep7ezoko	455	50	development	development	NN
cord-316534-ep7ezoko	455	51	:	:	:
cord-316534-ep7ezoko	455	52	induction	induction	NN
cord-316534-ep7ezoko	455	53	of	of	IN
cord-316534-ep7ezoko	455	54	HIV-1-specific	HIV-1-specific	NNP
cord-316534-ep7ezoko	455	55	humoral	humoral	JJ
cord-316534-ep7ezoko	455	56	and	and	CC
cord-316534-ep7ezoko	455	57	cellular	cellular	JJ
cord-316534-ep7ezoko	455	58	immune	immune	JJ
cord-316534-ep7ezoko	455	59	responses	response	NNS
cord-316534-ep7ezoko	455	60	in	in	IN
cord-316534-ep7ezoko	455	61	rhesus	rhesus	NN
cord-316534-ep7ezoko	455	62	macaques	macaque	NNS
cord-316534-ep7ezoko	455	63	using	use	VBG
cord-316534-ep7ezoko	455	64	a	a	DT
cord-316534-ep7ezoko	455	65	novel	novel	NN
cord-316534-ep7ezoko	455	66	MLV(HIV-1	MLV(HIV-1	NNS
cord-316534-ep7ezoko	455	67	)	)	-RRB-
cord-316534-ep7ezoko	455	68	pseudotype	pseudotype	NN
cord-316534-ep7ezoko	455	69	vector	vector	NN
cord-316534-ep7ezoko	455	70	A	a	DT
cord-316534-ep7ezoko	455	71	single	single	JJ
cord-316534-ep7ezoko	455	72	administration	administration	NN
cord-316534-ep7ezoko	455	73	of	of	IN
cord-316534-ep7ezoko	455	74	lentiviral	lentiviral	NNP
cord-316534-ep7ezoko	455	75	vectors	vector	NNS
cord-316534-ep7ezoko	455	76	expressing	express	VBG
cord-316534-ep7ezoko	455	77	either	either	CC
cord-316534-ep7ezoko	455	78	full	full	JJ
cord-316534-ep7ezoko	455	79	-	-	HYPH
cord-316534-ep7ezoko	455	80	length	length	NN
cord-316534-ep7ezoko	455	81	human	human	JJ
cord-316534-ep7ezoko	455	82	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	455	83	virus	virus	NN
cord-316534-ep7ezoko	455	84	1	1	CD
cord-316534-ep7ezoko	455	85	(	(	-LRB-
cord-316534-ep7ezoko	455	86	HIV-1)(HXB2	HIV-1)(HXB2	NNP
cord-316534-ep7ezoko	455	87	)	)	-RRB-
cord-316534-ep7ezoko	455	88	Rev	Rev	NNP
cord-316534-ep7ezoko	455	89	/	/	SYM
cord-316534-ep7ezoko	455	90	Env	Env	NNP
cord-316534-ep7ezoko	455	91	or	or	CC
cord-316534-ep7ezoko	455	92	codon	codon	NN
cord-316534-ep7ezoko	455	93	-	-	HYPH
cord-316534-ep7ezoko	455	94	optimized	optimize	VBN
cord-316534-ep7ezoko	455	95	HIV-1(JR	HIV-1(JR	NNP
cord-316534-ep7ezoko	455	96	-	-	HYPH
cord-316534-ep7ezoko	455	97	FL	FL	NNP
cord-316534-ep7ezoko	455	98	)	)	-RRB-
cord-316534-ep7ezoko	456	1	gp120	gp120	NNP
cord-316534-ep7ezoko	456	2	generates	generate	VBZ
cord-316534-ep7ezoko	456	3	durable	durable	JJ
cord-316534-ep7ezoko	456	4	immune	immune	JJ
cord-316534-ep7ezoko	456	5	responses	response	NNS
cord-316534-ep7ezoko	456	6	in	in	IN
cord-316534-ep7ezoko	456	7	mice	mouse	NNS
cord-316534-ep7ezoko	456	8	Rabies	Rabies	NNP
cord-316534-ep7ezoko	456	9	virus	virus	NN
cord-316534-ep7ezoko	456	10	-	-	HYPH
cord-316534-ep7ezoko	456	11	based	base	VBN
cord-316534-ep7ezoko	456	12	vaccines	vaccine	NNS
cord-316534-ep7ezoko	456	13	elicit	elicit	VBP
cord-316534-ep7ezoko	456	14	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	456	15	antibodies	antibody	NNS
cord-316534-ep7ezoko	456	16	,	,	,
cord-316534-ep7ezoko	456	17	poly	poly	JJ
cord-316534-ep7ezoko	456	18	-	-	HYPH
cord-316534-ep7ezoko	456	19	functional	functional	JJ
cord-316534-ep7ezoko	456	20	CD8	CD8	NNP
cord-316534-ep7ezoko	456	21	+	+	CC
cord-316534-ep7ezoko	456	22	T	T	NNP
cord-316534-ep7ezoko	456	23	cell	cell	NN
cord-316534-ep7ezoko	456	24	,	,	,
cord-316534-ep7ezoko	456	25	and	and	CC
cord-316534-ep7ezoko	456	26	protect	protect	VB
cord-316534-ep7ezoko	456	27	rhesus	rhesus	NN
cord-316534-ep7ezoko	456	28	macaques	macaque	NNS
cord-316534-ep7ezoko	456	29	from	from	IN
cord-316534-ep7ezoko	456	30	AIDS	AIDS	NNP
cord-316534-ep7ezoko	456	31	-	-	HYPH
cord-316534-ep7ezoko	456	32	like	like	JJ
cord-316534-ep7ezoko	456	33	disease	disease	NN
cord-316534-ep7ezoko	456	34	after	after	IN
cord-316534-ep7ezoko	456	35	SIV(mac251	SIV(mac251	NNP
cord-316534-ep7ezoko	456	36	)	)	-RRB-
cord-316534-ep7ezoko	456	37	challenge	challenge	NN
cord-316534-ep7ezoko	456	38	Highly	highly	RB
cord-316534-ep7ezoko	456	39	attenuated	attenuate	VBN
cord-316534-ep7ezoko	456	40	rabies	rabies	NN
cord-316534-ep7ezoko	456	41	virus	virus	NN
cord-316534-ep7ezoko	456	42	-	-	HYPH
cord-316534-ep7ezoko	456	43	based	base	VBN
cord-316534-ep7ezoko	456	44	vaccine	vaccine	NN
cord-316534-ep7ezoko	456	45	vectors	vector	NNS
cord-316534-ep7ezoko	456	46	expressing	express	VBG
cord-316534-ep7ezoko	456	47	simian	simian	JJ
cord-316534-ep7ezoko	456	48	-	-	HYPH
cord-316534-ep7ezoko	456	49	human	human	JJ
cord-316534-ep7ezoko	456	50	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	456	51	virus89.6P	virus89.6P	NNP
cord-316534-ep7ezoko	456	52	Env	Env	NNP
cord-316534-ep7ezoko	456	53	and	and	CC
cord-316534-ep7ezoko	456	54	simian	simian	JJ
cord-316534-ep7ezoko	456	55	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	457	1	virusmac239	virusmac239	NNP
cord-316534-ep7ezoko	457	2	Gag	Gag	NNP
cord-316534-ep7ezoko	457	3	are	be	VBP
cord-316534-ep7ezoko	457	4	safe	safe	JJ
cord-316534-ep7ezoko	457	5	in	in	IN
cord-316534-ep7ezoko	457	6	rhesus	rhesus	NN
cord-316534-ep7ezoko	457	7	macaques	macaque	NNS
cord-316534-ep7ezoko	457	8	and	and	CC
cord-316534-ep7ezoko	457	9	protect	protect	VB
cord-316534-ep7ezoko	457	10	from	from	IN
cord-316534-ep7ezoko	457	11	an	an	DT
cord-316534-ep7ezoko	457	12	AIDS	AIDS	NNP
cord-316534-ep7ezoko	457	13	-	-	HYPH
cord-316534-ep7ezoko	457	14	like	like	JJ
cord-316534-ep7ezoko	457	15	disease	disease	NN
cord-316534-ep7ezoko	457	16	Protection	Protection	NNP
cord-316534-ep7ezoko	457	17	of	of	IN
cord-316534-ep7ezoko	457	18	rhesus	rhesu	NNS
cord-316534-ep7ezoko	457	19	monkeys	monkey	NNS
cord-316534-ep7ezoko	457	20	against	against	IN
cord-316534-ep7ezoko	457	21	infection	infection	NN
cord-316534-ep7ezoko	457	22	with	with	IN
cord-316534-ep7ezoko	457	23	minimally	minimally	RB
cord-316534-ep7ezoko	457	24	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	457	25	simian	simian	JJ
cord-316534-ep7ezoko	457	26	-	-	HYPH
cord-316534-ep7ezoko	457	27	human	human	JJ
cord-316534-ep7ezoko	457	28	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	457	29	virus	virus	NN
cord-316534-ep7ezoko	457	30	:	:	:
cord-316534-ep7ezoko	457	31	correlations	correlation	NNS
cord-316534-ep7ezoko	457	32	with	with	IN
cord-316534-ep7ezoko	457	33	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	457	34	antibodies	antibody	NNS
cord-316534-ep7ezoko	457	35	and	and	CC
cord-316534-ep7ezoko	457	36	cytotoxic	cytotoxic	JJ
cord-316534-ep7ezoko	457	37	T	t	NN
cord-316534-ep7ezoko	457	38	cells	cell	NNS
cord-316534-ep7ezoko	457	39	Vaccination	vaccination	NN
cord-316534-ep7ezoko	457	40	with	with	IN
cord-316534-ep7ezoko	457	41	ALVAC	ALVAC	NNP
cord-316534-ep7ezoko	457	42	and	and	CC
cord-316534-ep7ezoko	457	43	AIDSVAX	AIDSVAX	NNP
cord-316534-ep7ezoko	457	44	to	to	TO
cord-316534-ep7ezoko	457	45	prevent	prevent	VB
cord-316534-ep7ezoko	457	46	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	457	47	infection	infection	NN
cord-316534-ep7ezoko	457	48	in	in	IN
cord-316534-ep7ezoko	457	49	Thailand	Thailand	NNP
cord-316534-ep7ezoko	457	50	Vector	vector	NN
cord-316534-ep7ezoko	457	51	-	-	HYPH
cord-316534-ep7ezoko	457	52	mediated	mediate	VBN
cord-316534-ep7ezoko	457	53	gene	gene	NN
cord-316534-ep7ezoko	457	54	transfer	transfer	NN
cord-316534-ep7ezoko	457	55	engenders	engender	VBZ
cord-316534-ep7ezoko	457	56	long	long	RB
cord-316534-ep7ezoko	457	57	-	-	HYPH
cord-316534-ep7ezoko	457	58	lived	live	VBN
cord-316534-ep7ezoko	457	59	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	457	60	activity	activity	NN
cord-316534-ep7ezoko	457	61	and	and	CC
cord-316534-ep7ezoko	457	62	protection	protection	NN
cord-316534-ep7ezoko	457	63	against	against	IN
cord-316534-ep7ezoko	457	64	SIV	SIV	NNP
cord-316534-ep7ezoko	457	65	infection	infection	NN
cord-316534-ep7ezoko	457	66	in	in	IN
cord-316534-ep7ezoko	457	67	monkeys	monkey	NNS
cord-316534-ep7ezoko	457	68	Enhancement	Enhancement	NNP
cord-316534-ep7ezoko	457	69	of	of	IN
cord-316534-ep7ezoko	457	70	humoral	humoral	JJ
cord-316534-ep7ezoko	457	71	immunity	immunity	NN
cord-316534-ep7ezoko	457	72	to	to	IN
cord-316534-ep7ezoko	457	73	SIVenv	SIVenv	NNP
cord-316534-ep7ezoko	457	74	following	follow	VBG
cord-316534-ep7ezoko	457	75	simultaneous	simultaneous	JJ
cord-316534-ep7ezoko	457	76	inoculation	inoculation	NN
cord-316534-ep7ezoko	457	77	of	of	IN
cord-316534-ep7ezoko	457	78	mice	mouse	NNS
cord-316534-ep7ezoko	457	79	by	by	IN
cord-316534-ep7ezoko	457	80	three	three	CD
cord-316534-ep7ezoko	457	81	recombinant	recombinant	JJ
cord-316534-ep7ezoko	457	82	adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	457	83	encoding	encode	VBG
cord-316534-ep7ezoko	457	84	SIVenv	SIVenv	NNP
cord-316534-ep7ezoko	457	85	/	/	SYM
cord-316534-ep7ezoko	457	86	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	457	87	chimeras	chimera	NNS
cord-316534-ep7ezoko	457	88	,	,	,
cord-316534-ep7ezoko	457	89	Tat	Tat	NNP
cord-316534-ep7ezoko	457	90	and	and	CC
cord-316534-ep7ezoko	457	91	Rev	Rev	NNP
cord-316534-ep7ezoko	457	92	Replication	Replication	NNP
cord-316534-ep7ezoko	457	93	-	-	HYPH
cord-316534-ep7ezoko	457	94	defective	defective	JJ
cord-316534-ep7ezoko	457	95	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	457	96	serotype	serotype	NN
cord-316534-ep7ezoko	457	97	5	5	CD
cord-316534-ep7ezoko	457	98	vectors	vector	NNS
cord-316534-ep7ezoko	457	99	elicit	elicit	VBP
cord-316534-ep7ezoko	457	100	durable	durable	JJ
cord-316534-ep7ezoko	457	101	cellular	cellular	JJ
cord-316534-ep7ezoko	457	102	and	and	CC
cord-316534-ep7ezoko	457	103	humoral	humoral	JJ
cord-316534-ep7ezoko	457	104	immune	immune	JJ
cord-316534-ep7ezoko	457	105	responses	response	NNS
cord-316534-ep7ezoko	457	106	in	in	IN
cord-316534-ep7ezoko	457	107	nonhuman	nonhuman	NN
cord-316534-ep7ezoko	457	108	primates	primate	NNS
cord-316534-ep7ezoko	458	1	Adenovirus	Adenovirus	NNP
cord-316534-ep7ezoko	458	2	vectored	vectore	VBD
cord-316534-ep7ezoko	458	3	vaccines	vaccine	NNS
cord-316534-ep7ezoko	458	4	Replication	replication	NN
cord-316534-ep7ezoko	458	5	-	-	HYPH
cord-316534-ep7ezoko	458	6	deficient	deficient	JJ
cord-316534-ep7ezoko	458	7	recombinant	recombinant	JJ
cord-316534-ep7ezoko	458	8	adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	458	9	expressing	express	VBG
cord-316534-ep7ezoko	458	10	the	the	DT
cord-316534-ep7ezoko	458	11	human	human	JJ
cord-316534-ep7ezoko	458	12	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	458	13	virus	virus	NN
cord-316534-ep7ezoko	458	14	Env	Env	NNP
cord-316534-ep7ezoko	458	15	antigen	antigen	NN
cord-316534-ep7ezoko	459	1	can	can	MD
cord-316534-ep7ezoko	459	2	induce	induce	VB
cord-316534-ep7ezoko	459	3	both	both	DT
cord-316534-ep7ezoko	459	4	humoral	humoral	JJ
cord-316534-ep7ezoko	459	5	and	and	CC
cord-316534-ep7ezoko	459	6	CTL	CTL	NNP
cord-316534-ep7ezoko	459	7	immune	immune	JJ
cord-316534-ep7ezoko	459	8	responses	response	NNS
cord-316534-ep7ezoko	459	9	in	in	IN
cord-316534-ep7ezoko	459	10	mice	mouse	NNS
cord-316534-ep7ezoko	459	11	Multi	multi	JJ
cord-316534-ep7ezoko	459	12	-	-	NN
cord-316534-ep7ezoko	459	13	envelope	envelope	NN
cord-316534-ep7ezoko	459	14	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	459	15	vaccine	vaccine	NN
cord-316534-ep7ezoko	459	16	devoid	devoid	NN
cord-316534-ep7ezoko	459	17	of	of	IN
cord-316534-ep7ezoko	459	18	SIV	SIV	NNP
cord-316534-ep7ezoko	459	19	components	component	NNS
cord-316534-ep7ezoko	460	1	controls	control	VBZ
cord-316534-ep7ezoko	460	2	disease	disease	NN
cord-316534-ep7ezoko	460	3	in	in	IN
cord-316534-ep7ezoko	460	4	macaques	macaque	NNS
cord-316534-ep7ezoko	460	5	challenged	challenge	VBN
cord-316534-ep7ezoko	460	6	with	with	IN
cord-316534-ep7ezoko	460	7	heterologous	heterologous	JJ
cord-316534-ep7ezoko	460	8	pathogenic	pathogenic	JJ
cord-316534-ep7ezoko	460	9	SHIV	SHIV	NNP
cord-316534-ep7ezoko	460	10	Cytotoxic	Cytotoxic	NNP
cord-316534-ep7ezoko	460	11	T	T	NNP
cord-316534-ep7ezoko	460	12	lymphocyte	lymphocyte	NN
cord-316534-ep7ezoko	460	13	and	and	CC
cord-316534-ep7ezoko	460	14	antibody	antibody	NN
cord-316534-ep7ezoko	460	15	responses	response	NNS
cord-316534-ep7ezoko	460	16	generated	generate	VBN
cord-316534-ep7ezoko	460	17	in	in	IN
cord-316534-ep7ezoko	460	18	rhesus	rhesu	NNS
cord-316534-ep7ezoko	460	19	monkeys	monkey	NNS
cord-316534-ep7ezoko	460	20	immunized	immunize	VBN
cord-316534-ep7ezoko	460	21	with	with	IN
cord-316534-ep7ezoko	460	22	retroviral	retroviral	JJ
cord-316534-ep7ezoko	460	23	vector	vector	NN
cord-316534-ep7ezoko	460	24	-	-	HYPH
cord-316534-ep7ezoko	460	25	transduced	transduce	VBN
cord-316534-ep7ezoko	460	26	fibroblasts	fibroblast	NNS
cord-316534-ep7ezoko	460	27	expressing	express	VBG
cord-316534-ep7ezoko	460	28	human	human	JJ
cord-316534-ep7ezoko	460	29	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	460	30	virus	virus	NN
cord-316534-ep7ezoko	460	31	type-1	type-1	NNP
cord-316534-ep7ezoko	460	32	IIIB	IIIB	NNP
cord-316534-ep7ezoko	460	33	ENV	ENV	NNP
cord-316534-ep7ezoko	460	34	/	/	SYM
cord-316534-ep7ezoko	460	35	REV	REV	NNP
cord-316534-ep7ezoko	460	36	proteins	protein	NNS
cord-316534-ep7ezoko	460	37	Evaluation	Evaluation	NNP
cord-316534-ep7ezoko	460	38	of	of	IN
cord-316534-ep7ezoko	460	39	a	a	DT
cord-316534-ep7ezoko	460	40	self	self	NN
cord-316534-ep7ezoko	460	41	-	-	HYPH
cord-316534-ep7ezoko	460	42	inactivating	inactivate	VBG
cord-316534-ep7ezoko	460	43	lentiviral	lentiviral	JJ
cord-316534-ep7ezoko	460	44	vector	vector	NN
cord-316534-ep7ezoko	460	45	expressing	express	VBG
cord-316534-ep7ezoko	460	46	simian	simian	JJ
cord-316534-ep7ezoko	460	47	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	460	48	virus	virus	NN
cord-316534-ep7ezoko	460	49	gag	gag	NN
cord-316534-ep7ezoko	460	50	for	for	IN
cord-316534-ep7ezoko	460	51	induction	induction	NN
cord-316534-ep7ezoko	460	52	of	of	IN
cord-316534-ep7ezoko	460	53	specific	specific	JJ
cord-316534-ep7ezoko	460	54	immune	immune	JJ
cord-316534-ep7ezoko	460	55	responses	response	NNS
cord-316534-ep7ezoko	460	56	in	in	IN
cord-316534-ep7ezoko	460	57	vitro	vitro	FW
cord-316534-ep7ezoko	460	58	and	and	CC
cord-316534-ep7ezoko	460	59	in	in	IN
cord-316534-ep7ezoko	460	60	vivo	vivo	NN
cord-316534-ep7ezoko	461	1	Chimaeric	Chimaeric	NNP
cord-316534-ep7ezoko	461	2	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	461	3	subtype	subtype	NN
cord-316534-ep7ezoko	461	4	C	c	NN
cord-316534-ep7ezoko	461	5	Gag	Gag	NNP
cord-316534-ep7ezoko	461	6	molecules	molecule	NNS
cord-316534-ep7ezoko	461	7	with	with	IN
cord-316534-ep7ezoko	461	8	large	large	JJ
cord-316534-ep7ezoko	461	9	in	in	IN
cord-316534-ep7ezoko	461	10	-	-	HYPH
cord-316534-ep7ezoko	461	11	frame	frame	NN
cord-316534-ep7ezoko	461	12	C	c	NN
cord-316534-ep7ezoko	461	13	-	-	HYPH
cord-316534-ep7ezoko	461	14	terminal	terminal	NN
cord-316534-ep7ezoko	461	15	polypeptide	polypeptide	NN
cord-316534-ep7ezoko	461	16	fusions	fusion	NNS
cord-316534-ep7ezoko	461	17	form	form	VBP
cord-316534-ep7ezoko	461	18	virus	virus	NN
cord-316534-ep7ezoko	461	19	-	-	:
cord-316534-ep7ezoko	461	20	like	like	JJ
cord-316534-ep7ezoko	461	21	particles	particle	NNS
cord-316534-ep7ezoko	461	22	Optimization	Optimization	NNP
cord-316534-ep7ezoko	461	23	of	of	IN
cord-316534-ep7ezoko	461	24	chimeric	chimeric	JJ
cord-316534-ep7ezoko	461	25	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	461	26	virus	virus	NN
cord-316534-ep7ezoko	461	27	-	-	HYPH
cord-316534-ep7ezoko	461	28	like	like	JJ
cord-316534-ep7ezoko	461	29	particle	particle	NN
cord-316534-ep7ezoko	461	30	production	production	NN
cord-316534-ep7ezoko	461	31	in	in	IN
cord-316534-ep7ezoko	461	32	a	a	DT
cord-316534-ep7ezoko	461	33	baculovirus	baculovirus	NN
cord-316534-ep7ezoko	461	34	-	-	HYPH
cord-316534-ep7ezoko	461	35	insect	insect	NN
cord-316534-ep7ezoko	461	36	cell	cell	NN
cord-316534-ep7ezoko	461	37	expression	expression	NN
cord-316534-ep7ezoko	461	38	system	system	NN
cord-316534-ep7ezoko	461	39	Increased	increase	VBN
cord-316534-ep7ezoko	461	40	incorporation	incorporation	NN
cord-316534-ep7ezoko	461	41	of	of	IN
cord-316534-ep7ezoko	461	42	chimeric	chimeric	JJ
cord-316534-ep7ezoko	461	43	human	human	JJ
cord-316534-ep7ezoko	461	44	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	461	45	virus	virus	NN
cord-316534-ep7ezoko	461	46	type	type	NN
cord-316534-ep7ezoko	461	47	1	1	CD
cord-316534-ep7ezoko	461	48	gp120	gp120	NNP
cord-316534-ep7ezoko	461	49	proteins	protein	NNS
cord-316534-ep7ezoko	461	50	into	into	IN
cord-316534-ep7ezoko	461	51	Pr55	Pr55	NNP
cord-316534-ep7ezoko	461	52	gag	gag	NN
cord-316534-ep7ezoko	461	53	virus	virus	NN
cord-316534-ep7ezoko	461	54	-	-	HYPH
cord-316534-ep7ezoko	461	55	like	like	JJ
cord-316534-ep7ezoko	461	56	particles	particle	NNS
cord-316534-ep7ezoko	461	57	by	by	IN
cord-316534-ep7ezoko	461	58	an	an	DT
cord-316534-ep7ezoko	461	59	Epstein	Epstein	NNP
cord-316534-ep7ezoko	461	60	-	-	HYPH
cord-316534-ep7ezoko	461	61	Barr	Barr	NNP
cord-316534-ep7ezoko	461	62	virus	virus	NN
cord-316534-ep7ezoko	461	63	gp220/350-derived	gp220/350-derived	NNP
cord-316534-ep7ezoko	461	64	transmembrane	transmembrane	NN
cord-316534-ep7ezoko	461	65	domain	domain	NN
cord-316534-ep7ezoko	461	66	Recombinant	recombinant	JJ
cord-316534-ep7ezoko	461	67	human	human	JJ
cord-316534-ep7ezoko	461	68	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	461	69	Pr55	Pr55	NNP
cord-316534-ep7ezoko	462	1	gag	gag	NN
cord-316534-ep7ezoko	462	2	virus	virus	NN
cord-316534-ep7ezoko	462	3	-	-	HYPH
cord-316534-ep7ezoko	462	4	like	like	JJ
cord-316534-ep7ezoko	462	5	particles	particle	NNS
cord-316534-ep7ezoko	462	6	presenting	present	VBG
cord-316534-ep7ezoko	462	7	chimeric	chimeric	JJ
cord-316534-ep7ezoko	462	8	envelope	envelope	NN
cord-316534-ep7ezoko	462	9	glycoproteins	glycoprotein	NNS
cord-316534-ep7ezoko	462	10	induce	induce	VBP
cord-316534-ep7ezoko	462	11	cytotoxic	cytotoxic	JJ
cord-316534-ep7ezoko	462	12	T	t	NN
cord-316534-ep7ezoko	462	13	-	-	HYPH
cord-316534-ep7ezoko	462	14	cells	cell	NNS
cord-316534-ep7ezoko	462	15	and	and	CC
cord-316534-ep7ezoko	462	16	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	462	17	antibodies	antibody	NNS
cord-316534-ep7ezoko	462	18	Development	Development	NNP
cord-316534-ep7ezoko	462	19	of	of	IN
cord-316534-ep7ezoko	462	20	HIV	HIV	NNP
cord-316534-ep7ezoko	462	21	/	/	SYM
cord-316534-ep7ezoko	462	22	AIDS	AIDS	NNP
cord-316534-ep7ezoko	462	23	vaccine	vaccine	NN
cord-316534-ep7ezoko	462	24	using	use	VBG
cord-316534-ep7ezoko	462	25	chimeric	chimeric	JJ
cord-316534-ep7ezoko	462	26	gag	gag	NN
cord-316534-ep7ezoko	462	27	-	-	HYPH
cord-316534-ep7ezoko	462	28	env	env	NN
cord-316534-ep7ezoko	462	29	virus	virus	NN
cord-316534-ep7ezoko	462	30	-	-	HYPH
cord-316534-ep7ezoko	462	31	like	like	JJ
cord-316534-ep7ezoko	462	32	particles	particle	NNS
cord-316534-ep7ezoko	462	33	DNA	dna	NN
cord-316534-ep7ezoko	462	34	vaccines	vaccine	NNS
cord-316534-ep7ezoko	462	35	Induction	Induction	NNP
cord-316534-ep7ezoko	462	36	of	of	IN
cord-316534-ep7ezoko	462	37	gp120-specific	gp120-specific	JJ
cord-316534-ep7ezoko	462	38	protective	protective	JJ
cord-316534-ep7ezoko	462	39	immune	immune	JJ
cord-316534-ep7ezoko	462	40	responses	response	NNS
cord-316534-ep7ezoko	462	41	by	by	IN
cord-316534-ep7ezoko	462	42	genetic	genetic	JJ
cord-316534-ep7ezoko	462	43	vaccination	vaccination	NN
cord-316534-ep7ezoko	462	44	with	with	IN
cord-316534-ep7ezoko	462	45	linear	linear	JJ
cord-316534-ep7ezoko	462	46	polyethylenimine	polyethylenimine	JJ
cord-316534-ep7ezoko	462	47	-	-	HYPH
cord-316534-ep7ezoko	462	48	plasmid	plasmid	JJ
cord-316534-ep7ezoko	462	49	complex	complex	JJ
cord-316534-ep7ezoko	462	50	DNA	dna	NN
cord-316534-ep7ezoko	462	51	vaccines	vaccine	NNS
cord-316534-ep7ezoko	462	52	:	:	:
cord-316534-ep7ezoko	462	53	a	a	DT
cord-316534-ep7ezoko	462	54	review	review	NN
cord-316534-ep7ezoko	462	55	Comparison	comparison	NN
cord-316534-ep7ezoko	462	56	of	of	IN
cord-316534-ep7ezoko	462	57	protective	protective	JJ
cord-316534-ep7ezoko	462	58	effect	effect	NN
cord-316534-ep7ezoko	462	59	of	of	IN
cord-316534-ep7ezoko	462	60	protein	protein	NN
cord-316534-ep7ezoko	462	61	and	and	CC
cord-316534-ep7ezoko	462	62	DNA	dna	NN
cord-316534-ep7ezoko	462	63	vaccines	vaccine	NNS
cord-316534-ep7ezoko	462	64	hsp90	hsp90	VBN
cord-316534-ep7ezoko	462	65	in	in	IN
cord-316534-ep7ezoko	462	66	murine	murine	JJ
cord-316534-ep7ezoko	462	67	model	model	NN
cord-316534-ep7ezoko	462	68	of	of	IN
cord-316534-ep7ezoko	462	69	systemic	systemic	JJ
cord-316534-ep7ezoko	462	70	candidiasis	candidiasis	NN
cord-316534-ep7ezoko	462	71	DNA	dna	NN
cord-316534-ep7ezoko	462	72	vaccines	vaccine	NNS
cord-316534-ep7ezoko	462	73	against	against	IN
cord-316534-ep7ezoko	462	74	human	human	JJ
cord-316534-ep7ezoko	462	75	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	462	76	virus	virus	NN
cord-316534-ep7ezoko	462	77	type	type	NN
cord-316534-ep7ezoko	462	78	1	1	CD
cord-316534-ep7ezoko	462	79	in	in	IN
cord-316534-ep7ezoko	462	80	the	the	DT
cord-316534-ep7ezoko	462	81	past	past	JJ
cord-316534-ep7ezoko	462	82	decade	decade	NN
cord-316534-ep7ezoko	462	83	Direct	direct	JJ
cord-316534-ep7ezoko	462	84	gene	gene	NN
cord-316534-ep7ezoko	462	85	transfer	transfer	NN
cord-316534-ep7ezoko	462	86	into	into	IN
cord-316534-ep7ezoko	462	87	mouse	mouse	NN
cord-316534-ep7ezoko	462	88	muscle	muscle	NN
cord-316534-ep7ezoko	462	89	in	in	IN
cord-316534-ep7ezoko	462	90	vivo	vivo	NNP
cord-316534-ep7ezoko	462	91	Enhancement	Enhancement	NNP
cord-316534-ep7ezoko	462	92	of	of	IN
cord-316534-ep7ezoko	462	93	human	human	JJ
cord-316534-ep7ezoko	462	94	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	462	95	virus	virus	NN
cord-316534-ep7ezoko	462	96	type	type	NN
cord-316534-ep7ezoko	462	97	1-DNA	1-dna	CD
cord-316534-ep7ezoko	462	98	vaccine	vaccine	NN
cord-316534-ep7ezoko	462	99	potency	potency	NN
cord-316534-ep7ezoko	462	100	through	through	IN
cord-316534-ep7ezoko	462	101	incorporation	incorporation	NN
cord-316534-ep7ezoko	462	102	of	of	IN
cord-316534-ep7ezoko	462	103	T	T	NNP
cord-316534-ep7ezoko	462	104	-	-	HYPH
cord-316534-ep7ezoko	462	105	helper	helper	NN
cord-316534-ep7ezoko	462	106	1	1	CD
cord-316534-ep7ezoko	462	107	molecular	molecular	JJ
cord-316534-ep7ezoko	462	108	adjuvants	adjuvant	NNS
cord-316534-ep7ezoko	462	109	Modulation	modulation	NN
cord-316534-ep7ezoko	462	110	of	of	IN
cord-316534-ep7ezoko	462	111	cellular	cellular	JJ
cord-316534-ep7ezoko	462	112	and	and	CC
cord-316534-ep7ezoko	462	113	humoral	humoral	JJ
cord-316534-ep7ezoko	462	114	immune	immune	JJ
cord-316534-ep7ezoko	462	115	responses	response	NNS
cord-316534-ep7ezoko	462	116	to	to	IN
cord-316534-ep7ezoko	462	117	a	a	DT
cord-316534-ep7ezoko	462	118	multiepitopic	multiepitopic	NNP
cord-316534-ep7ezoko	462	119	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	462	120	DNA	DNA	NNP
cord-316534-ep7ezoko	462	121	vaccine	vaccine	NN
cord-316534-ep7ezoko	462	122	by	by	IN
cord-316534-ep7ezoko	462	123	interleukin-18	interleukin-18	NNP
cord-316534-ep7ezoko	463	1	DNA	DNA	NNP
cord-316534-ep7ezoko	463	2	immunization/	immunization/	NNP
cord-316534-ep7ezoko	463	3	viral	viral	JJ
cord-316534-ep7ezoko	463	4	protein	protein	NN
cord-316534-ep7ezoko	463	5	boost	boost	NN
cord-316534-ep7ezoko	463	6	Evaluation	evaluation	NN
cord-316534-ep7ezoko	463	7	in	in	IN
cord-316534-ep7ezoko	463	8	macaques	macaque	NNS
cord-316534-ep7ezoko	463	9	of	of	IN
cord-316534-ep7ezoko	463	10	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	463	11	DNA	DNA	NNP
cord-316534-ep7ezoko	463	12	vaccines	vaccine	NNS
cord-316534-ep7ezoko	463	13	containing	contain	VBG
cord-316534-ep7ezoko	463	14	primate	primate	JJ
cord-316534-ep7ezoko	463	15	CpG	CpG	NNP
cord-316534-ep7ezoko	463	16	motifs	motifs	NNP
cord-316534-ep7ezoko	463	17	and	and	CC
cord-316534-ep7ezoko	463	18	fowlpoxvirus	fowlpoxvirus	NNP
cord-316534-ep7ezoko	463	19	vaccines	vaccine	NNS
cord-316534-ep7ezoko	463	20	co	co	VBD
cord-316534-ep7ezoko	463	21	-	-	JJ
cord-316534-ep7ezoko	463	22	expressing	express	VBG
cord-316534-ep7ezoko	463	23	IFNgamma	IFNgamma	NNP
cord-316534-ep7ezoko	463	24	or	or	CC
cord-316534-ep7ezoko	463	25	IL-12	IL-12	NNP
cord-316534-ep7ezoko	463	26	Augmentation	augmentation	NN
cord-316534-ep7ezoko	463	27	and	and	CC
cord-316534-ep7ezoko	463	28	suppression	suppression	NN
cord-316534-ep7ezoko	463	29	of	of	IN
cord-316534-ep7ezoko	463	30	immune	immune	JJ
cord-316534-ep7ezoko	463	31	responses	response	NNS
cord-316534-ep7ezoko	463	32	to	to	IN
cord-316534-ep7ezoko	463	33	an	an	DT
cord-316534-ep7ezoko	463	34	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	463	35	DNA	dna	NN
cord-316534-ep7ezoko	463	36	vaccine	vaccine	NN
cord-316534-ep7ezoko	463	37	by	by	IN
cord-316534-ep7ezoko	463	38	plasmid	plasmid	NN
cord-316534-ep7ezoko	463	39	cytokine	cytokine	NN
cord-316534-ep7ezoko	463	40	/	/	SYM
cord-316534-ep7ezoko	463	41	Ig	Ig	NNP
cord-316534-ep7ezoko	463	42	administration	administration	NN
cord-316534-ep7ezoko	463	43	Cell	cell	NN
cord-316534-ep7ezoko	463	44	-	-	HYPH
cord-316534-ep7ezoko	463	45	specific	specific	JJ
cord-316534-ep7ezoko	463	46	delivery	delivery	NN
cord-316534-ep7ezoko	463	47	of	of	IN
cord-316534-ep7ezoko	463	48	genes	gene	NNS
cord-316534-ep7ezoko	463	49	with	with	IN
cord-316534-ep7ezoko	463	50	glycosylated	glycosylated	JJ
cord-316534-ep7ezoko	463	51	carriers	carrier	NNS
cord-316534-ep7ezoko	463	52	Organspecific	organspecific	JJ
cord-316534-ep7ezoko	463	53	gene	gene	NN
cord-316534-ep7ezoko	463	54	expression	expression	NN
cord-316534-ep7ezoko	463	55	in	in	IN
cord-316534-ep7ezoko	463	56	the	the	DT
cord-316534-ep7ezoko	463	57	rhesus	rhesus	NNP
cord-316534-ep7ezoko	463	58	monkey	monkey	NNP
cord-316534-ep7ezoko	463	59	eye	eye	NN
cord-316534-ep7ezoko	463	60	following	follow	VBG
cord-316534-ep7ezoko	463	61	intravenous	intravenous	JJ
cord-316534-ep7ezoko	463	62	non	non	JJ
cord-316534-ep7ezoko	463	63	-	-	JJ
cord-316534-ep7ezoko	463	64	viral	viral	JJ
cord-316534-ep7ezoko	463	65	gene	gene	NN
cord-316534-ep7ezoko	463	66	transfer	transfer	NN
cord-316534-ep7ezoko	463	67	Systemic	systemic	JJ
cord-316534-ep7ezoko	463	68	linear	linear	JJ
cord-316534-ep7ezoko	463	69	polyethylenimine	polyethylenimine	NN
cord-316534-ep7ezoko	464	1	(	(	-LRB-
cord-316534-ep7ezoko	464	2	L	l	NN
cord-316534-ep7ezoko	464	3	-	-	HYPH
cord-316534-ep7ezoko	464	4	PEI)-mediated	pei)-mediate	VBN
cord-316534-ep7ezoko	464	5	gene	gene	NN
cord-316534-ep7ezoko	464	6	delivery	delivery	NN
cord-316534-ep7ezoko	464	7	in	in	IN
cord-316534-ep7ezoko	464	8	the	the	DT
cord-316534-ep7ezoko	464	9	mouse	mouse	NN
cord-316534-ep7ezoko	464	10	Targeted	target	VBN
cord-316534-ep7ezoko	464	11	gene	gene	NN
cord-316534-ep7ezoko	464	12	delivery	delivery	NN
cord-316534-ep7ezoko	464	13	to	to	IN
cord-316534-ep7ezoko	464	14	cancer	cancer	NN
cord-316534-ep7ezoko	464	15	cells	cell	NNS
cord-316534-ep7ezoko	464	16	:	:	:
cord-316534-ep7ezoko	464	17	directed	direct	VBN
cord-316534-ep7ezoko	464	18	assembly	assembly	NNP
cord-316534-ep7ezoko	464	19	of	of	IN
cord-316534-ep7ezoko	464	20	nanometric	nanometric	NNP
cord-316534-ep7ezoko	464	21	DNA	DNA	NNP
cord-316534-ep7ezoko	464	22	particles	particle	NNS
cord-316534-ep7ezoko	464	23	coated	coat	VBN
cord-316534-ep7ezoko	464	24	with	with	IN
cord-316534-ep7ezoko	464	25	folic	folic	JJ
cord-316534-ep7ezoko	464	26	acid	acid	NN
cord-316534-ep7ezoko	464	27	An	an	DT
cord-316534-ep7ezoko	464	28	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	464	29	clade	clade	NN
cord-316534-ep7ezoko	464	30	C	c	NN
cord-316534-ep7ezoko	464	31	DNA	dna	NN
cord-316534-ep7ezoko	464	32	prime	prime	NN
cord-316534-ep7ezoko	464	33	,	,	,
cord-316534-ep7ezoko	464	34	NYVAC	NYVAC	NNP
cord-316534-ep7ezoko	464	35	boost	boost	VBP
cord-316534-ep7ezoko	464	36	vaccine	vaccine	NN
cord-316534-ep7ezoko	464	37	regimen	regimen	NN
cord-316534-ep7ezoko	464	38	induces	induce	VBZ
cord-316534-ep7ezoko	464	39	reliable	reliable	JJ
cord-316534-ep7ezoko	464	40	,	,	,
cord-316534-ep7ezoko	464	41	polyfunctional	polyfunctional	JJ
cord-316534-ep7ezoko	464	42	,	,	,
cord-316534-ep7ezoko	464	43	and	and	CC
cord-316534-ep7ezoko	464	44	long	long	RB
cord-316534-ep7ezoko	464	45	-	-	HYPH
cord-316534-ep7ezoko	464	46	lasting	last	VBG
cord-316534-ep7ezoko	464	47	T	t	NN
cord-316534-ep7ezoko	464	48	cell	cell	NN
cord-316534-ep7ezoko	464	49	responses	response	NNS
cord-316534-ep7ezoko	464	50	Safety	safety	NN
cord-316534-ep7ezoko	464	51	and	and	CC
cord-316534-ep7ezoko	464	52	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	464	53	study	study	NN
cord-316534-ep7ezoko	464	54	of	of	IN
cord-316534-ep7ezoko	464	55	multiclade	multiclade	NNP
cord-316534-ep7ezoko	464	56	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	464	57	adenoviral	adenoviral	NNP
cord-316534-ep7ezoko	464	58	vector	vector	NN
cord-316534-ep7ezoko	464	59	vaccine	vaccine	NN
cord-316534-ep7ezoko	464	60	alone	alone	RB
cord-316534-ep7ezoko	464	61	or	or	CC
cord-316534-ep7ezoko	464	62	as	as	IN
cord-316534-ep7ezoko	464	63	boost	boost	NN
cord-316534-ep7ezoko	464	64	following	follow	VBG
cord-316534-ep7ezoko	464	65	a	a	DT
cord-316534-ep7ezoko	464	66	multiclade	multiclade	JJ
cord-316534-ep7ezoko	464	67	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	464	68	DNA	DNA	NNP
cord-316534-ep7ezoko	464	69	vaccine	vaccine	NN
cord-316534-ep7ezoko	464	70	in	in	IN
cord-316534-ep7ezoko	464	71	Africa	Africa	NNP
cord-316534-ep7ezoko	464	72	Differential	Differential	NNP
cord-316534-ep7ezoko	464	73	effect	effect	NN
cord-316534-ep7ezoko	464	74	of	of	IN
cord-316534-ep7ezoko	464	75	lentil	lentil	NN
cord-316534-ep7ezoko	464	76	feeding	feeding	NN
cord-316534-ep7ezoko	464	77	on	on	IN
cord-316534-ep7ezoko	464	78	proteosynthesis	proteosynthesis	NN
cord-316534-ep7ezoko	464	79	rates	rate	NNS
cord-316534-ep7ezoko	464	80	in	in	IN
cord-316534-ep7ezoko	464	81	the	the	DT
cord-316534-ep7ezoko	464	82	large	large	JJ
cord-316534-ep7ezoko	464	83	intestine	intestine	NN
cord-316534-ep7ezoko	464	84	,	,	,
cord-316534-ep7ezoko	464	85	liver	liver	NN
cord-316534-ep7ezoko	464	86	and	and	CC
cord-316534-ep7ezoko	464	87	muscle	muscle	NN
cord-316534-ep7ezoko	464	88	of	of	IN
cord-316534-ep7ezoko	464	89	rats	rat	NNS
cord-316534-ep7ezoko	464	90	Delivery	Delivery	NNP
cord-316534-ep7ezoko	464	91	of	of	IN
cord-316534-ep7ezoko	464	92	DNA	DNA	NNP
cord-316534-ep7ezoko	464	93	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	464	94	vaccine	vaccine	NN
cord-316534-ep7ezoko	464	95	to	to	IN
cord-316534-ep7ezoko	464	96	the	the	DT
cord-316534-ep7ezoko	464	97	liver	liver	NN
cord-316534-ep7ezoko	464	98	induces	induce	VBZ
cord-316534-ep7ezoko	464	99	high	high	JJ
cord-316534-ep7ezoko	464	100	and	and	CC
cord-316534-ep7ezoko	464	101	long	long	RB
cord-316534-ep7ezoko	464	102	-	-	HYPH
cord-316534-ep7ezoko	464	103	lasting	last	VBG
cord-316534-ep7ezoko	464	104	humoral	humoral	JJ
cord-316534-ep7ezoko	464	105	immune	immune	JJ
cord-316534-ep7ezoko	464	106	responses	response	NNS
cord-316534-ep7ezoko	464	107	Immunopathogenesis	Immunopathogenesis	NNP
cord-316534-ep7ezoko	464	108	and	and	CC
cord-316534-ep7ezoko	464	109	immunotherapy	immunotherapy	NN
cord-316534-ep7ezoko	464	110	in	in	IN
cord-316534-ep7ezoko	464	111	AIDS	AIDS	NNP
cord-316534-ep7ezoko	464	112	virus	virus	NN
cord-316534-ep7ezoko	464	113	infections	infection	VBZ
cord-316534-ep7ezoko	464	114	A	a	DT
cord-316534-ep7ezoko	464	115	role	role	NN
cord-316534-ep7ezoko	464	116	for	for	IN
cord-316534-ep7ezoko	464	117	carbohydrates	carbohydrate	NNS
cord-316534-ep7ezoko	464	118	in	in	IN
cord-316534-ep7ezoko	464	119	immune	immune	JJ
cord-316534-ep7ezoko	464	120	evasion	evasion	NN
cord-316534-ep7ezoko	464	121	in	in	IN
cord-316534-ep7ezoko	464	122	AIDS	AIDS	NNP
cord-316534-ep7ezoko	464	123	Electrically	electrically	RB
cord-316534-ep7ezoko	464	124	mediated	mediate	VBN
cord-316534-ep7ezoko	464	125	plasmid	plasmid	NN
cord-316534-ep7ezoko	464	126	DNA	dna	NN
cord-316534-ep7ezoko	464	127	delivery	delivery	NN
cord-316534-ep7ezoko	464	128	to	to	IN
cord-316534-ep7ezoko	464	129	hepatocellular	hepatocellular	JJ
cord-316534-ep7ezoko	464	130	carcinomas	carcinoma	NNS
cord-316534-ep7ezoko	464	131	in	in	IN
cord-316534-ep7ezoko	464	132	vivo	vivo	NNP
cord-316534-ep7ezoko	464	133	Tail	tail	NN
cord-316534-ep7ezoko	464	134	-	-	HYPH
cord-316534-ep7ezoko	464	135	vein	vein	NN
cord-316534-ep7ezoko	464	136	injection	injection	NN
cord-316534-ep7ezoko	464	137	of	of	IN
cord-316534-ep7ezoko	464	138	mannan	mannan	NNP
cord-316534-ep7ezoko	464	139	-	-	HYPH
cord-316534-ep7ezoko	464	140	binding	bind	VBG
cord-316534-ep7ezoko	464	141	lectin	lectin	NN
cord-316534-ep7ezoko	464	142	DNA	dna	NN
cord-316534-ep7ezoko	464	143	leads	lead	VBZ
cord-316534-ep7ezoko	464	144	to	to	IN
cord-316534-ep7ezoko	464	145	high	high	JJ
cord-316534-ep7ezoko	464	146	expression	expression	NN
cord-316534-ep7ezoko	464	147	levels	level	NNS
cord-316534-ep7ezoko	464	148	of	of	IN
cord-316534-ep7ezoko	464	149	multimeric	multimeric	JJ
cord-316534-ep7ezoko	464	150	protein	protein	NN
cord-316534-ep7ezoko	464	151	in	in	IN
cord-316534-ep7ezoko	464	152	liver	liver	NN
cord-316534-ep7ezoko	464	153	Mechanism	Mechanism	NNP
cord-316534-ep7ezoko	464	154	of	of	IN
cord-316534-ep7ezoko	464	155	plasmid	plasmid	NN
cord-316534-ep7ezoko	464	156	delivery	delivery	NN
cord-316534-ep7ezoko	464	157	by	by	IN
cord-316534-ep7ezoko	464	158	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	464	159	tail	tail	NN
cord-316534-ep7ezoko	464	160	vein	vein	NN
cord-316534-ep7ezoko	464	161	injection	injection	NN
cord-316534-ep7ezoko	464	162	.	.	.
cord-316534-ep7ezoko	465	1	II	II	NNP
cord-316534-ep7ezoko	465	2	.	.	.
cord-316534-ep7ezoko	466	1	Morphological	morphological	JJ
cord-316534-ep7ezoko	466	2	studies	study	NNS
cord-316534-ep7ezoko	466	3	Mechanism	Mechanism	NNP
cord-316534-ep7ezoko	466	4	of	of	IN
cord-316534-ep7ezoko	466	5	plasmid	plasmid	NNP
cord-316534-ep7ezoko	467	1	delivery	delivery	NN
cord-316534-ep7ezoko	467	2	by	by	IN
cord-316534-ep7ezoko	467	3	hydrodynamic	hydrodynamic	JJ
cord-316534-ep7ezoko	467	4	tail	tail	NN
cord-316534-ep7ezoko	467	5	vein	vein	NN
cord-316534-ep7ezoko	467	6	injection	injection	NN
cord-316534-ep7ezoko	467	7	.	.	.
cord-316534-ep7ezoko	468	1	I.	I.	NNP
cord-316534-ep7ezoko	468	2	Hepatocyte	Hepatocyte	NNP
cord-316534-ep7ezoko	468	3	uptake	uptake	NN
cord-316534-ep7ezoko	468	4	of	of	IN
cord-316534-ep7ezoko	468	5	various	various	JJ
cord-316534-ep7ezoko	468	6	molecules	molecule	NNS
cord-316534-ep7ezoko	469	1	The	the	DT
cord-316534-ep7ezoko	469	2	efficient	efficient	JJ
cord-316534-ep7ezoko	469	3	expression	expression	NN
cord-316534-ep7ezoko	469	4	of	of	IN
cord-316534-ep7ezoko	469	5	intravascularly	intravascularly	RB
cord-316534-ep7ezoko	469	6	delivered	deliver	VBN
cord-316534-ep7ezoko	469	7	DNA	dna	NN
cord-316534-ep7ezoko	469	8	in	in	IN
cord-316534-ep7ezoko	469	9	rat	rat	NN
cord-316534-ep7ezoko	469	10	muscle	muscle	NN
cord-316534-ep7ezoko	469	11	Hydrodynamics	Hydrodynamics	NNP
cord-316534-ep7ezoko	469	12	-	-	HYPH
cord-316534-ep7ezoko	469	13	based	base	VBN
cord-316534-ep7ezoko	469	14	transfection	transfection	NN
cord-316534-ep7ezoko	469	15	in	in	IN
cord-316534-ep7ezoko	469	16	animals	animal	NNS
cord-316534-ep7ezoko	469	17	by	by	IN
cord-316534-ep7ezoko	469	18	systemic	systemic	JJ
cord-316534-ep7ezoko	469	19	administration	administration	NN
cord-316534-ep7ezoko	469	20	of	of	IN
cord-316534-ep7ezoko	469	21	plasmid	plasmid	NNP
cord-316534-ep7ezoko	469	22	DNA	DNA	NNP
cord-316534-ep7ezoko	469	23	High	High	NNP
cord-316534-ep7ezoko	469	24	levels	level	NNS
cord-316534-ep7ezoko	469	25	of	of	IN
cord-316534-ep7ezoko	469	26	foreign	foreign	JJ
cord-316534-ep7ezoko	469	27	gene	gene	NN
cord-316534-ep7ezoko	469	28	expression	expression	NN
cord-316534-ep7ezoko	469	29	in	in	IN
cord-316534-ep7ezoko	469	30	hepatocytes	hepatocyte	NNS
cord-316534-ep7ezoko	469	31	after	after	IN
cord-316534-ep7ezoko	469	32	tail	tail	NN
cord-316534-ep7ezoko	469	33	vein	vein	NN
cord-316534-ep7ezoko	469	34	injections	injection	NNS
cord-316534-ep7ezoko	469	35	of	of	IN
cord-316534-ep7ezoko	469	36	naked	naked	JJ
cord-316534-ep7ezoko	469	37	plasmid	plasmid	NN
cord-316534-ep7ezoko	469	38	DNA	DNA	NNP
cord-316534-ep7ezoko	469	39	Hydrodynamic	Hydrodynamic	NNP
cord-316534-ep7ezoko	469	40	gene	gene	NN
cord-316534-ep7ezoko	469	41	delivery	delivery	NN
cord-316534-ep7ezoko	469	42	:	:	:
cord-316534-ep7ezoko	470	1	its	-PRON-	PRP$
cord-316534-ep7ezoko	470	2	principles	principle	NNS
cord-316534-ep7ezoko	470	3	and	and	CC
cord-316534-ep7ezoko	470	4	applications	application	NNS
cord-316534-ep7ezoko	471	1	The	the	DT
cord-316534-ep7ezoko	471	2	asialoglycoprotein	asialoglycoprotein	NNP
cord-316534-ep7ezoko	471	3	receptor	receptor	NN
cord-316534-ep7ezoko	471	4	:	:	:
cord-316534-ep7ezoko	472	1	relationships	relationship	NNS
cord-316534-ep7ezoko	472	2	between	between	IN
cord-316534-ep7ezoko	472	3	structure	structure	NN
cord-316534-ep7ezoko	472	4	,	,	,
cord-316534-ep7ezoko	472	5	function	function	NN
cord-316534-ep7ezoko	472	6	,	,	,
cord-316534-ep7ezoko	472	7	and	and	CC
cord-316534-ep7ezoko	472	8	expression	expression	NN
cord-316534-ep7ezoko	472	9	Synthesis	Synthesis	NNP
cord-316534-ep7ezoko	472	10	of	of	IN
cord-316534-ep7ezoko	472	11	antisense	antisense	NN
cord-316534-ep7ezoko	472	12	oligonucleotides	oligonucleotide	NNS
cord-316534-ep7ezoko	472	13	conjugated	conjugate	VBN
cord-316534-ep7ezoko	472	14	to	to	IN
cord-316534-ep7ezoko	472	15	a	a	DT
cord-316534-ep7ezoko	472	16	multivalent	multivalent	JJ
cord-316534-ep7ezoko	472	17	carbohydrate	carbohydrate	NN
cord-316534-ep7ezoko	472	18	cluster	cluster	NN
cord-316534-ep7ezoko	472	19	for	for	IN
cord-316534-ep7ezoko	472	20	cellular	cellular	JJ
cord-316534-ep7ezoko	472	21	targeting	target	VBG
cord-316534-ep7ezoko	472	22	Adenovirus	Adenovirus	NNP
cord-316534-ep7ezoko	472	23	serotype	serotype	NN
cord-316534-ep7ezoko	472	24	5	5	CD
cord-316534-ep7ezoko	472	25	hexon	hexon	NNP
cord-316534-ep7ezoko	472	26	mediates	mediate	VBZ
cord-316534-ep7ezoko	472	27	liver	liver	NN
cord-316534-ep7ezoko	472	28	gene	gene	NN
cord-316534-ep7ezoko	472	29	transfer	transfer	NN
cord-316534-ep7ezoko	472	30	Adenovirus	Adenovirus	NNP
cord-316534-ep7ezoko	472	31	serotype	serotype	NN
cord-316534-ep7ezoko	472	32	5	5	CD
cord-316534-ep7ezoko	472	33	hexon	hexon	NN
cord-316534-ep7ezoko	472	34	is	be	VBZ
cord-316534-ep7ezoko	472	35	critical	critical	JJ
cord-316534-ep7ezoko	472	36	for	for	IN
cord-316534-ep7ezoko	472	37	virus	virus	NN
cord-316534-ep7ezoko	472	38	infection	infection	NN
cord-316534-ep7ezoko	472	39	of	of	IN
cord-316534-ep7ezoko	472	40	hepatocytes	hepatocyte	NNS
cord-316534-ep7ezoko	472	41	in	in	IN
cord-316534-ep7ezoko	472	42	vivo	vivo	NN
cord-316534-ep7ezoko	472	43	Viral	viral	JJ
cord-316534-ep7ezoko	472	44	vectors	vector	NNS
cord-316534-ep7ezoko	472	45	for	for	IN
cord-316534-ep7ezoko	472	46	malaria	malaria	NN
cord-316534-ep7ezoko	472	47	vaccine	vaccine	NN
cord-316534-ep7ezoko	472	48	development	development	NN
cord-316534-ep7ezoko	472	49	Human	Human	NNP
cord-316534-ep7ezoko	472	50	rhinovirus	rhinovirus	NN
cord-316534-ep7ezoko	472	51	type	type	NN
cord-316534-ep7ezoko	472	52	14	14	CD
cord-316534-ep7ezoko	472	53	:	:	:
cord-316534-ep7ezoko	473	1	human	human	JJ
cord-316534-ep7ezoko	473	2	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	473	3	virus	virus	NN
cord-316534-ep7ezoko	473	4	type	type	NN
cord-316534-ep7ezoko	473	5	1	1	CD
cord-316534-ep7ezoko	474	1	(	(	-LRB-
cord-316534-ep7ezoko	474	2	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	474	3	)	)	-RRB-
cord-316534-ep7ezoko	474	4	V3	v3	NN
cord-316534-ep7ezoko	474	5	loop	loop	NN
cord-316534-ep7ezoko	474	6	chimeras	chimera	NNS
cord-316534-ep7ezoko	474	7	from	from	IN
cord-316534-ep7ezoko	474	8	a	a	DT
cord-316534-ep7ezoko	474	9	combinatorial	combinatorial	JJ
cord-316534-ep7ezoko	474	10	library	library	NN
cord-316534-ep7ezoko	474	11	induce	induce	VBP
cord-316534-ep7ezoko	474	12	potent	potent	JJ
cord-316534-ep7ezoko	474	13	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	474	14	antibody	antibody	NN
cord-316534-ep7ezoko	474	15	responses	response	NNS
cord-316534-ep7ezoko	474	16	against	against	IN
cord-316534-ep7ezoko	474	17	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	474	18	Broad	Broad	NNP
cord-316534-ep7ezoko	474	19	neutralization	neutralization	NN
cord-316534-ep7ezoko	474	20	of	of	IN
cord-316534-ep7ezoko	474	21	human	human	JJ
cord-316534-ep7ezoko	474	22	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	474	23	virus	virus	NN
cord-316534-ep7ezoko	474	24	type	type	NN
cord-316534-ep7ezoko	474	25	1	1	CD
cord-316534-ep7ezoko	475	1	(	(	-LRB-
cord-316534-ep7ezoko	475	2	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	475	3	)	)	-RRB-
cord-316534-ep7ezoko	475	4	elicited	elicit	VBD
cord-316534-ep7ezoko	475	5	from	from	IN
cord-316534-ep7ezoko	475	6	human	human	JJ
cord-316534-ep7ezoko	475	7	rhinoviruses	rhinovirus	NNS
cord-316534-ep7ezoko	475	8	that	that	WDT
cord-316534-ep7ezoko	475	9	display	display	VBP
cord-316534-ep7ezoko	475	10	the	the	DT
cord-316534-ep7ezoko	475	11	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	475	12	gp41	gp41	NNP
cord-316534-ep7ezoko	475	13	ELDKWA	ELDKWA	NNP
cord-316534-ep7ezoko	475	14	epitope	epitope	NN
cord-316534-ep7ezoko	475	15	Use	use	NN
cord-316534-ep7ezoko	475	16	of	of	IN
cord-316534-ep7ezoko	475	17	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	475	18	in	in	IN
cord-316534-ep7ezoko	475	19	vaccines	vaccine	NNS
cord-316534-ep7ezoko	475	20	for	for	IN
cord-316534-ep7ezoko	475	21	HIV	HIV	NNP
cord-316534-ep7ezoko	475	22	Development	Development	NNP
cord-316534-ep7ezoko	475	23	of	of	IN
cord-316534-ep7ezoko	475	24	nonhuman	nonhuman	NN
cord-316534-ep7ezoko	475	25	adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	475	26	as	as	IN
cord-316534-ep7ezoko	475	27	vaccine	vaccine	NN
cord-316534-ep7ezoko	475	28	vectors	vector	VBZ
cord-316534-ep7ezoko	475	29	Poliovirus	Poliovirus	NNP
cord-316534-ep7ezoko	475	30	vaccine	vaccine	NN
cord-316534-ep7ezoko	475	31	strains	strain	NNS
cord-316534-ep7ezoko	475	32	as	as	IN
cord-316534-ep7ezoko	475	33	mucosal	mucosal	JJ
cord-316534-ep7ezoko	475	34	vaccine	vaccine	NN
cord-316534-ep7ezoko	475	35	vectors	vector	NNS
cord-316534-ep7ezoko	475	36	and	and	CC
cord-316534-ep7ezoko	475	37	their	-PRON-	PRP$
cord-316534-ep7ezoko	475	38	potential	potential	JJ
cord-316534-ep7ezoko	475	39	use	use	NN
cord-316534-ep7ezoko	475	40	to	to	TO
cord-316534-ep7ezoko	475	41	develop	develop	VB
cord-316534-ep7ezoko	475	42	an	an	DT
cord-316534-ep7ezoko	475	43	AIDS	AIDS	NNP
cord-316534-ep7ezoko	475	44	vaccine	vaccine	NN
cord-316534-ep7ezoko	475	45	Control	Control	NNP
cord-316534-ep7ezoko	475	46	of	of	IN
cord-316534-ep7ezoko	475	47	a	a	DT
cord-316534-ep7ezoko	475	48	mucosal	mucosal	JJ
cord-316534-ep7ezoko	475	49	challenge	challenge	NN
cord-316534-ep7ezoko	475	50	and	and	CC
cord-316534-ep7ezoko	475	51	prevention	prevention	NN
cord-316534-ep7ezoko	475	52	of	of	IN
cord-316534-ep7ezoko	475	53	AIDS	AIDS	NNP
cord-316534-ep7ezoko	475	54	by	by	IN
cord-316534-ep7ezoko	475	55	a	a	DT
cord-316534-ep7ezoko	475	56	multiprotein	multiprotein	NNP
cord-316534-ep7ezoko	475	57	DNA	DNA	NNP
cord-316534-ep7ezoko	475	58	/	/	SYM
cord-316534-ep7ezoko	475	59	MVA	MVA	NNP
cord-316534-ep7ezoko	475	60	vaccine	vaccine	NN
cord-316534-ep7ezoko	475	61	Recombinant	recombinant	JJ
cord-316534-ep7ezoko	475	62	poxviruses	poxvirus	NNS
cord-316534-ep7ezoko	475	63	as	as	IN
cord-316534-ep7ezoko	475	64	mucosal	mucosal	JJ
cord-316534-ep7ezoko	475	65	vaccine	vaccine	NN
cord-316534-ep7ezoko	475	66	vectors	vector	NNS
cord-316534-ep7ezoko	475	67	Induction	Induction	NNP
cord-316534-ep7ezoko	475	68	of	of	IN
cord-316534-ep7ezoko	475	69	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	475	70	antibody	antibody	NN
cord-316534-ep7ezoko	475	71	responses	response	NNS
cord-316534-ep7ezoko	475	72	to	to	IN
cord-316534-ep7ezoko	475	73	anthrax	anthrax	NN
cord-316534-ep7ezoko	475	74	protective	protective	JJ
cord-316534-ep7ezoko	475	75	antigen	antigen	NN
cord-316534-ep7ezoko	475	76	by	by	IN
cord-316534-ep7ezoko	475	77	using	use	VBG
cord-316534-ep7ezoko	475	78	influenza	influenza	NN
cord-316534-ep7ezoko	475	79	virus	virus	NN
cord-316534-ep7ezoko	475	80	vectors	vector	NNS
cord-316534-ep7ezoko	475	81	:	:	:
cord-316534-ep7ezoko	475	82	implications	implication	NNS
cord-316534-ep7ezoko	475	83	for	for	IN
cord-316534-ep7ezoko	475	84	disparate	disparate	JJ
cord-316534-ep7ezoko	475	85	immune	immune	JJ
cord-316534-ep7ezoko	475	86	system	system	NN
cord-316534-ep7ezoko	475	87	priming	prime	VBG
cord-316534-ep7ezoko	475	88	pathways	pathway	NNS
cord-316534-ep7ezoko	476	1	Subcutaneous	subcutaneous	JJ
cord-316534-ep7ezoko	476	2	administration	administration	NN
cord-316534-ep7ezoko	476	3	of	of	IN
cord-316534-ep7ezoko	476	4	a	a	DT
cord-316534-ep7ezoko	476	5	recombinant	recombinant	JJ
cord-316534-ep7ezoko	476	6	vaccinia	vaccinia	NN
cord-316534-ep7ezoko	476	7	virus	virus	NN
cord-316534-ep7ezoko	476	8	vaccine	vaccine	NN
cord-316534-ep7ezoko	476	9	expressing	express	VBG
cord-316534-ep7ezoko	476	10	multiple	multiple	JJ
cord-316534-ep7ezoko	476	11	envelopes	envelope	NNS
cord-316534-ep7ezoko	476	12	of	of	IN
cord-316534-ep7ezoko	476	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	476	14	An	an	DT
cord-316534-ep7ezoko	476	15	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	476	16	vector	vector	NN
cord-316534-ep7ezoko	476	17	with	with	IN
cord-316534-ep7ezoko	476	18	genetically	genetically	RB
cord-316534-ep7ezoko	476	19	modified	modify	VBN
cord-316534-ep7ezoko	476	20	fibers	fiber	NNS
cord-316534-ep7ezoko	476	21	demonstrates	demonstrate	VBZ
cord-316534-ep7ezoko	476	22	expanded	expand	VBN
cord-316534-ep7ezoko	476	23	tropism	tropism	NN
cord-316534-ep7ezoko	476	24	via	via	IN
cord-316534-ep7ezoko	476	25	utilization	utilization	NN
cord-316534-ep7ezoko	476	26	of	of	IN
cord-316534-ep7ezoko	476	27	a	a	DT
cord-316534-ep7ezoko	476	28	coxsackievirus	coxsackievirus	NN
cord-316534-ep7ezoko	476	29	and	and	CC
cord-316534-ep7ezoko	476	30	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	476	31	receptor	receptor	NN
cord-316534-ep7ezoko	476	32	-	-	HYPH
cord-316534-ep7ezoko	476	33	independent	independent	JJ
cord-316534-ep7ezoko	476	34	cell	cell	NN
cord-316534-ep7ezoko	476	35	entry	entry	NN
cord-316534-ep7ezoko	476	36	mechanism	mechanism	NN
cord-316534-ep7ezoko	477	1	Targeted	target	VBN
cord-316534-ep7ezoko	477	2	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	477	3	vectors	vector	NNS
cord-316534-ep7ezoko	477	4	Viral	viral	JJ
cord-316534-ep7ezoko	477	5	vectors	vector	NNS
cord-316534-ep7ezoko	477	6	for	for	IN
cord-316534-ep7ezoko	477	7	gene	gene	NN
cord-316534-ep7ezoko	477	8	therapy	therapy	NN
cord-316534-ep7ezoko	477	9	:	:	:
cord-316534-ep7ezoko	478	1	the	the	DT
cord-316534-ep7ezoko	478	2	art	art	NN
cord-316534-ep7ezoko	478	3	of	of	IN
cord-316534-ep7ezoko	478	4	turning	turn	VBG
cord-316534-ep7ezoko	478	5	infectious	infectious	JJ
cord-316534-ep7ezoko	478	6	agents	agent	NNS
cord-316534-ep7ezoko	478	7	into	into	IN
cord-316534-ep7ezoko	478	8	vehicles	vehicle	NNS
cord-316534-ep7ezoko	478	9	of	of	IN
cord-316534-ep7ezoko	478	10	therapeutics	therapeutic	NNS
cord-316534-ep7ezoko	478	11	Live	live	VBP
cord-316534-ep7ezoko	478	12	attenuated	attenuated	JJ
cord-316534-ep7ezoko	478	13	measles	measle	NNS
cord-316534-ep7ezoko	478	14	vaccine	vaccine	NN
cord-316534-ep7ezoko	478	15	as	as	IN
cord-316534-ep7ezoko	478	16	a	a	DT
cord-316534-ep7ezoko	478	17	potential	potential	JJ
cord-316534-ep7ezoko	478	18	multivalent	multivalent	JJ
cord-316534-ep7ezoko	478	19	pediatric	pediatric	JJ
cord-316534-ep7ezoko	478	20	vaccination	vaccination	NN
cord-316534-ep7ezoko	478	21	vector	vector	NN
cord-316534-ep7ezoko	478	22	Infection	infection	NN
cord-316534-ep7ezoko	478	23	of	of	IN
cord-316534-ep7ezoko	478	24	monocytes	monocyte	NNS
cord-316534-ep7ezoko	478	25	during	during	IN
cord-316534-ep7ezoko	478	26	measles	measle	NNS
cord-316534-ep7ezoko	478	27	Vaccinology	Vaccinology	NNP
cord-316534-ep7ezoko	478	28	,	,	,
cord-316534-ep7ezoko	478	29	immunology	immunology	NN
cord-316534-ep7ezoko	478	30	,	,	,
cord-316534-ep7ezoko	478	31	and	and	CC
cord-316534-ep7ezoko	478	32	comparative	comparative	JJ
cord-316534-ep7ezoko	478	33	pathogenesis	pathogenesis	NN
cord-316534-ep7ezoko	478	34	of	of	IN
cord-316534-ep7ezoko	478	35	measles	measle	NNS
cord-316534-ep7ezoko	478	36	in	in	IN
cord-316534-ep7ezoko	478	37	the	the	DT
cord-316534-ep7ezoko	478	38	quest	quest	NN
cord-316534-ep7ezoko	478	39	for	for	IN
cord-316534-ep7ezoko	478	40	a	a	DT
cord-316534-ep7ezoko	478	41	preventative	preventative	NN
cord-316534-ep7ezoko	478	42	against	against	IN
cord-316534-ep7ezoko	478	43	AIDS	AIDS	NNP
cord-316534-ep7ezoko	478	44	Preexisting	Preexisting	NNP
cord-316534-ep7ezoko	478	45	immunity	immunity	NN
cord-316534-ep7ezoko	478	46	to	to	IN
cord-316534-ep7ezoko	478	47	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	478	48	does	do	VBZ
cord-316534-ep7ezoko	478	49	not	not	RB
cord-316534-ep7ezoko	478	50	impair	impair	VB
cord-316534-ep7ezoko	478	51	the	the	DT
cord-316534-ep7ezoko	478	52	efficacy	efficacy	NN
cord-316534-ep7ezoko	478	53	of	of	IN
cord-316534-ep7ezoko	478	54	recombinant	recombinant	JJ
cord-316534-ep7ezoko	478	55	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	478	56	vaccine	vaccine	NN
cord-316534-ep7ezoko	478	57	vectors	vector	VBZ
cord-316534-ep7ezoko	478	58	Strategies	strategy	NNS
cord-316534-ep7ezoko	478	59	to	to	TO
cord-316534-ep7ezoko	478	60	overcome	overcome	VB
cord-316534-ep7ezoko	478	61	host	host	NN
cord-316534-ep7ezoko	478	62	immunity	immunity	NN
cord-316534-ep7ezoko	478	63	to	to	IN
cord-316534-ep7ezoko	478	64	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	478	65	vectors	vector	NNS
cord-316534-ep7ezoko	478	66	in	in	IN
cord-316534-ep7ezoko	478	67	vaccine	vaccine	NN
cord-316534-ep7ezoko	478	68	development	development	NN
cord-316534-ep7ezoko	479	1	Neutralizing	neutralize	VBG
cord-316534-ep7ezoko	479	2	antibodies	antibody	NNS
cord-316534-ep7ezoko	479	3	to	to	IN
cord-316534-ep7ezoko	479	4	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	479	5	serotype	serotype	NN
cord-316534-ep7ezoko	479	6	5	5	CD
cord-316534-ep7ezoko	479	7	vaccine	vaccine	NN
cord-316534-ep7ezoko	479	8	vectors	vector	NNS
cord-316534-ep7ezoko	479	9	are	be	VBP
cord-316534-ep7ezoko	479	10	directed	direct	VBN
cord-316534-ep7ezoko	479	11	primarily	primarily	RB
cord-316534-ep7ezoko	479	12	against	against	IN
cord-316534-ep7ezoko	479	13	the	the	DT
cord-316534-ep7ezoko	479	14	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	479	15	hexon	hexon	NN
cord-316534-ep7ezoko	479	16	protein	protein	NN
cord-316534-ep7ezoko	479	17	Construction	construction	NN
cord-316534-ep7ezoko	479	18	and	and	CC
cord-316534-ep7ezoko	479	19	characterization	characterization	NN
cord-316534-ep7ezoko	479	20	of	of	IN
cord-316534-ep7ezoko	479	21	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	479	22	serotype	serotype	NN
cord-316534-ep7ezoko	479	23	5	5	CD
cord-316534-ep7ezoko	479	24	packaged	package	VBN
cord-316534-ep7ezoko	479	25	by	by	IN
cord-316534-ep7ezoko	479	26	serotype	serotype	NN
cord-316534-ep7ezoko	479	27	3	3	CD
cord-316534-ep7ezoko	479	28	hexon	hexon	NN
cord-316534-ep7ezoko	479	29	Hexon	Hexon	NNP
cord-316534-ep7ezoko	479	30	-	-	HYPH
cord-316534-ep7ezoko	479	31	chimaeric	chimaeric	JJ
cord-316534-ep7ezoko	479	32	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	479	33	serotype	serotype	NN
cord-316534-ep7ezoko	479	34	5	5	CD
cord-316534-ep7ezoko	479	35	vectors	vector	NNS
cord-316534-ep7ezoko	479	36	circumvent	circumvent	VBP
cord-316534-ep7ezoko	479	37	pre	pre	JJ
cord-316534-ep7ezoko	479	38	-	-	JJ
cord-316534-ep7ezoko	479	39	existing	existing	JJ
cord-316534-ep7ezoko	479	40	anti	anti	JJ
cord-316534-ep7ezoko	479	41	-	-	JJ
cord-316534-ep7ezoko	479	42	vector	vector	JJ
cord-316534-ep7ezoko	479	43	immunity	immunity	NN
cord-316534-ep7ezoko	479	44	Immune	immune	JJ
cord-316534-ep7ezoko	479	45	responses	response	NNS
cord-316534-ep7ezoko	479	46	to	to	IN
cord-316534-ep7ezoko	479	47	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	479	48	and	and	CC
cord-316534-ep7ezoko	479	49	adeno	adeno	NN
cord-316534-ep7ezoko	479	50	-	-	HYPH
cord-316534-ep7ezoko	479	51	associated	associate	VBN
cord-316534-ep7ezoko	479	52	virus	virus	NN
cord-316534-ep7ezoko	479	53	in	in	IN
cord-316534-ep7ezoko	479	54	humans	human	NNS
cord-316534-ep7ezoko	480	1	The	the	DT
cord-316534-ep7ezoko	480	2	impact	impact	NN
cord-316534-ep7ezoko	480	3	of	of	IN
cord-316534-ep7ezoko	480	4	developmental	developmental	JJ
cord-316534-ep7ezoko	480	5	stage	stage	NN
cord-316534-ep7ezoko	480	6	,	,	,
cord-316534-ep7ezoko	480	7	route	route	NN
cord-316534-ep7ezoko	480	8	of	of	IN
cord-316534-ep7ezoko	480	9	administration	administration	NN
cord-316534-ep7ezoko	480	10	and	and	CC
cord-316534-ep7ezoko	480	11	the	the	DT
cord-316534-ep7ezoko	480	12	immune	immune	JJ
cord-316534-ep7ezoko	480	13	system	system	NN
cord-316534-ep7ezoko	480	14	on	on	IN
cord-316534-ep7ezoko	480	15	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	16	-	-	HYPH
cord-316534-ep7ezoko	480	17	mediated	mediate	VBN
cord-316534-ep7ezoko	480	18	gene	gene	NN
cord-316534-ep7ezoko	480	19	transfer	transfer	NN
cord-316534-ep7ezoko	480	20	Circumventing	circumvent	VBG
cord-316534-ep7ezoko	480	21	the	the	DT
cord-316534-ep7ezoko	480	22	immune	immune	JJ
cord-316534-ep7ezoko	480	23	response	response	NN
cord-316534-ep7ezoko	480	24	to	to	IN
cord-316534-ep7ezoko	480	25	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	26	-	-	HYPH
cord-316534-ep7ezoko	480	27	mediated	mediate	VBN
cord-316534-ep7ezoko	480	28	gene	gene	NN
cord-316534-ep7ezoko	480	29	therapy	therapy	NN
cord-316534-ep7ezoko	480	30	Hexon	Hexon	NNP
cord-316534-ep7ezoko	480	31	gene	gene	NN
cord-316534-ep7ezoko	480	32	switch	switch	NN
cord-316534-ep7ezoko	480	33	strategy	strategy	NN
cord-316534-ep7ezoko	480	34	for	for	IN
cord-316534-ep7ezoko	480	35	the	the	DT
cord-316534-ep7ezoko	480	36	generation	generation	NN
cord-316534-ep7ezoko	480	37	of	of	IN
cord-316534-ep7ezoko	480	38	chimeric	chimeric	JJ
cord-316534-ep7ezoko	480	39	recombinant	recombinant	JJ
cord-316534-ep7ezoko	480	40	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	41	Sero	Sero	NNP
cord-316534-ep7ezoko	480	42	-	-	HYPH
cord-316534-ep7ezoko	480	43	switch	switch	NN
cord-316534-ep7ezoko	480	44	'	'	''
cord-316534-ep7ezoko	480	45	adenovirusmediated	adenovirusmediate	VBN
cord-316534-ep7ezoko	480	46	in	in	IN
cord-316534-ep7ezoko	480	47	vivo	vivo	NNP
cord-316534-ep7ezoko	480	48	gene	gene	NN
cord-316534-ep7ezoko	480	49	transfer	transfer	NN
cord-316534-ep7ezoko	480	50	:	:	:
cord-316534-ep7ezoko	480	51	circumvention	circumvention	NN
cord-316534-ep7ezoko	480	52	of	of	IN
cord-316534-ep7ezoko	480	53	anti	anti	JJ
cord-316534-ep7ezoko	480	54	-	-	JJ
cord-316534-ep7ezoko	480	55	adenovirus	adenovirus	JJ
cord-316534-ep7ezoko	480	56	humoral	humoral	JJ
cord-316534-ep7ezoko	480	57	immune	immune	JJ
cord-316534-ep7ezoko	480	58	defenses	defense	NNS
cord-316534-ep7ezoko	480	59	against	against	IN
cord-316534-ep7ezoko	480	60	repeat	repeat	NN
cord-316534-ep7ezoko	480	61	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	62	vector	vector	NN
cord-316534-ep7ezoko	480	63	administration	administration	NN
cord-316534-ep7ezoko	480	64	by	by	IN
cord-316534-ep7ezoko	480	65	changing	change	VBG
cord-316534-ep7ezoko	480	66	the	the	DT
cord-316534-ep7ezoko	480	67	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	68	serotype	serotype	NN
cord-316534-ep7ezoko	480	69	Circumvention	circumvention	NN
cord-316534-ep7ezoko	480	70	of	of	IN
cord-316534-ep7ezoko	480	71	vectorspecific	vectorspecific	NNP
cord-316534-ep7ezoko	480	72	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	480	73	antibody	antibody	NN
cord-316534-ep7ezoko	480	74	response	response	NN
cord-316534-ep7ezoko	480	75	by	by	IN
cord-316534-ep7ezoko	480	76	alternating	alternate	VBG
cord-316534-ep7ezoko	480	77	use	use	NN
cord-316534-ep7ezoko	480	78	of	of	IN
cord-316534-ep7ezoko	480	79	human	human	JJ
cord-316534-ep7ezoko	480	80	and	and	CC
cord-316534-ep7ezoko	480	81	non	non	JJ
cord-316534-ep7ezoko	480	82	-	-	JJ
cord-316534-ep7ezoko	480	83	human	human	JJ
cord-316534-ep7ezoko	480	84	adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	480	85	:	:	:
cord-316534-ep7ezoko	480	86	implications	implication	NNS
cord-316534-ep7ezoko	480	87	in	in	IN
cord-316534-ep7ezoko	480	88	gene	gene	NN
cord-316534-ep7ezoko	480	89	therapy	therapy	NN
cord-316534-ep7ezoko	480	90	Generation	generation	NN
cord-316534-ep7ezoko	480	91	of	of	IN
cord-316534-ep7ezoko	480	92	a	a	DT
cord-316534-ep7ezoko	480	93	novel	novel	JJ
cord-316534-ep7ezoko	480	94	replication	replication	NN
cord-316534-ep7ezoko	480	95	-	-	HYPH
cord-316534-ep7ezoko	480	96	incompetent	incompetent	JJ
cord-316534-ep7ezoko	480	97	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	480	98	vector	vector	NN
cord-316534-ep7ezoko	480	99	derived	derive	VBN
cord-316534-ep7ezoko	480	100	from	from	IN
cord-316534-ep7ezoko	480	101	human	human	JJ
cord-316534-ep7ezoko	480	102	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	103	type	type	NN
cord-316534-ep7ezoko	480	104	49	49	CD
cord-316534-ep7ezoko	480	105	:	:	:
cord-316534-ep7ezoko	480	106	manufacture	manufacture	VB
cord-316534-ep7ezoko	480	107	on	on	IN
cord-316534-ep7ezoko	480	108	PER.C6	PER.C6	NNP
cord-316534-ep7ezoko	480	109	cells	cell	NNS
cord-316534-ep7ezoko	480	110	,	,	,
cord-316534-ep7ezoko	480	111	tropism	tropism	NN
cord-316534-ep7ezoko	480	112	and	and	CC
cord-316534-ep7ezoko	480	113	immunogenicity	immunogenicity	JJ
cord-316534-ep7ezoko	480	114	Dependence	dependence	NN
cord-316534-ep7ezoko	480	115	of	of	IN
cord-316534-ep7ezoko	480	116	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	117	infectivity	infectivity	NN
cord-316534-ep7ezoko	480	118	on	on	IN
cord-316534-ep7ezoko	480	119	length	length	NN
cord-316534-ep7ezoko	480	120	of	of	IN
cord-316534-ep7ezoko	480	121	the	the	DT
cord-316534-ep7ezoko	480	122	fiber	fiber	NN
cord-316534-ep7ezoko	480	123	shaft	shaft	NN
cord-316534-ep7ezoko	480	124	domain	domain	NN
cord-316534-ep7ezoko	480	125	Adenovirus	Adenovirus	NNP
cord-316534-ep7ezoko	480	126	type	type	NN
cord-316534-ep7ezoko	480	127	40	40	CD
cord-316534-ep7ezoko	480	128	virions	virion	NNS
cord-316534-ep7ezoko	480	129	contain	contain	VBP
cord-316534-ep7ezoko	480	130	two	two	CD
cord-316534-ep7ezoko	480	131	distinct	distinct	JJ
cord-316534-ep7ezoko	480	132	fibers	fiber	NNS
cord-316534-ep7ezoko	480	133	Human	human	JJ
cord-316534-ep7ezoko	480	134	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	135	type	type	NN
cord-316534-ep7ezoko	480	136	41	41	CD
cord-316534-ep7ezoko	480	137	contains	contain	VBZ
cord-316534-ep7ezoko	480	138	two	two	CD
cord-316534-ep7ezoko	480	139	fibers	fiber	NNS
cord-316534-ep7ezoko	480	140	Structure	structure	NN
cord-316534-ep7ezoko	480	141	-	-	HYPH
cord-316534-ep7ezoko	480	142	based	base	VBN
cord-316534-ep7ezoko	480	143	identification	identification	NN
cord-316534-ep7ezoko	480	144	of	of	IN
cord-316534-ep7ezoko	480	145	a	a	DT
cord-316534-ep7ezoko	480	146	major	major	JJ
cord-316534-ep7ezoko	480	147	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	480	148	site	site	NN
cord-316534-ep7ezoko	480	149	in	in	IN
cord-316534-ep7ezoko	480	150	an	an	DT
cord-316534-ep7ezoko	480	151	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	152	hexon	hexon	NN
cord-316534-ep7ezoko	480	153	Characterization	characterization	NN
cord-316534-ep7ezoko	480	154	of	of	IN
cord-316534-ep7ezoko	480	155	a	a	DT
cord-316534-ep7ezoko	480	156	family	family	NN
cord-316534-ep7ezoko	480	157	of	of	IN
cord-316534-ep7ezoko	480	158	chimpanzee	chimpanzee	NN
cord-316534-ep7ezoko	480	159	adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	480	160	and	and	CC
cord-316534-ep7ezoko	480	161	development	development	NN
cord-316534-ep7ezoko	480	162	of	of	IN
cord-316534-ep7ezoko	480	163	molecular	molecular	JJ
cord-316534-ep7ezoko	480	164	clones	clone	NNS
cord-316534-ep7ezoko	480	165	for	for	IN
cord-316534-ep7ezoko	480	166	gene	gene	NN
cord-316534-ep7ezoko	480	167	transfer	transfer	NN
cord-316534-ep7ezoko	480	168	vectors	vector	NNS
cord-316534-ep7ezoko	480	169	Replication	replication	NN
cord-316534-ep7ezoko	480	170	-	-	HYPH
cord-316534-ep7ezoko	480	171	defective	defective	JJ
cord-316534-ep7ezoko	480	172	vector	vector	NN
cord-316534-ep7ezoko	480	173	based	base	VBN
cord-316534-ep7ezoko	480	174	on	on	IN
cord-316534-ep7ezoko	480	175	a	a	DT
cord-316534-ep7ezoko	480	176	chimpanzee	chimpanzee	NN
cord-316534-ep7ezoko	480	177	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	178	Chimpanzee	chimpanzee	NN
cord-316534-ep7ezoko	480	179	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	480	180	vaccine	vaccine	NN
cord-316534-ep7ezoko	480	181	protects	protect	VBZ
cord-316534-ep7ezoko	480	182	against	against	IN
cord-316534-ep7ezoko	481	1	Zaire	Zaire	NNP
cord-316534-ep7ezoko	481	2	Ebola	Ebola	NNP
cord-316534-ep7ezoko	481	3	virus	virus	NN
cord-316534-ep7ezoko	481	4	Efficient	efficient	JJ
cord-316534-ep7ezoko	481	5	FLPe	FLPe	NNP
cord-316534-ep7ezoko	481	6	recombinase	recombinase	NN
cord-316534-ep7ezoko	481	7	enables	enable	VBZ
cord-316534-ep7ezoko	481	8	scalable	scalable	JJ
cord-316534-ep7ezoko	481	9	production	production	NN
cord-316534-ep7ezoko	481	10	of	of	IN
cord-316534-ep7ezoko	481	11	helper	helper	NN
cord-316534-ep7ezoko	481	12	-	-	HYPH
cord-316534-ep7ezoko	481	13	dependent	dependent	JJ
cord-316534-ep7ezoko	481	14	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	15	vectors	vector	NNS
cord-316534-ep7ezoko	481	16	with	with	IN
cord-316534-ep7ezoko	481	17	negligible	negligible	JJ
cord-316534-ep7ezoko	481	18	helper	helper	NN
cord-316534-ep7ezoko	481	19	-	-	HYPH
cord-316534-ep7ezoko	481	20	virus	virus	NN
cord-316534-ep7ezoko	481	21	contamination	contamination	NN
cord-316534-ep7ezoko	481	22	High	high	JJ
cord-316534-ep7ezoko	481	23	-	-	HYPH
cord-316534-ep7ezoko	481	24	capacity	capacity	NN
cord-316534-ep7ezoko	481	25	,	,	,
cord-316534-ep7ezoko	481	26	helperdependent	helperdependent	NN
cord-316534-ep7ezoko	481	27	,	,	,
cord-316534-ep7ezoko	481	28	'	'	``
cord-316534-ep7ezoko	481	29	gutless	gutless	JJ
cord-316534-ep7ezoko	481	30	'	'	''
cord-316534-ep7ezoko	481	31	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	32	vectors	vector	NNS
cord-316534-ep7ezoko	481	33	for	for	IN
cord-316534-ep7ezoko	481	34	gene	gene	NN
cord-316534-ep7ezoko	481	35	transfer	transfer	NN
cord-316534-ep7ezoko	481	36	into	into	IN
cord-316534-ep7ezoko	481	37	brain	brain	NN
cord-316534-ep7ezoko	481	38	Regulatable	Regulatable	NNP
cord-316534-ep7ezoko	481	39	gutless	gutless	JJ
cord-316534-ep7ezoko	481	40	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	41	vectors	vector	NNS
cord-316534-ep7ezoko	481	42	sustain	sustain	VBP
cord-316534-ep7ezoko	481	43	inducible	inducible	JJ
cord-316534-ep7ezoko	481	44	transgene	transgene	NN
cord-316534-ep7ezoko	481	45	expression	expression	NN
cord-316534-ep7ezoko	481	46	in	in	IN
cord-316534-ep7ezoko	481	47	the	the	DT
cord-316534-ep7ezoko	481	48	brain	brain	NN
cord-316534-ep7ezoko	481	49	in	in	IN
cord-316534-ep7ezoko	481	50	the	the	DT
cord-316534-ep7ezoko	481	51	presence	presence	NN
cord-316534-ep7ezoko	481	52	of	of	IN
cord-316534-ep7ezoko	481	53	an	an	DT
cord-316534-ep7ezoko	481	54	immune	immune	JJ
cord-316534-ep7ezoko	481	55	response	response	NN
cord-316534-ep7ezoko	481	56	against	against	IN
cord-316534-ep7ezoko	481	57	adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	481	58	Immunization	Immunization	NNP
cord-316534-ep7ezoko	481	59	against	against	IN
cord-316534-ep7ezoko	481	60	the	the	DT
cord-316534-ep7ezoko	481	61	transgene	transgene	NN
cord-316534-ep7ezoko	481	62	but	but	CC
cord-316534-ep7ezoko	481	63	not	not	RB
cord-316534-ep7ezoko	481	64	the	the	DT
cord-316534-ep7ezoko	481	65	TetON	TetON	NNP
cord-316534-ep7ezoko	481	66	switch	switch	NN
cord-316534-ep7ezoko	481	67	reduces	reduce	VBZ
cord-316534-ep7ezoko	481	68	expression	expression	NN
cord-316534-ep7ezoko	481	69	from	from	IN
cord-316534-ep7ezoko	481	70	gutless	gutless	JJ
cord-316534-ep7ezoko	481	71	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	72	vectors	vector	NNS
cord-316534-ep7ezoko	481	73	in	in	IN
cord-316534-ep7ezoko	481	74	the	the	DT
cord-316534-ep7ezoko	481	75	brain	brain	NN
cord-316534-ep7ezoko	481	76	Comparison	comparison	NN
cord-316534-ep7ezoko	481	77	of	of	IN
cord-316534-ep7ezoko	481	78	replicationcompetent	replicationcompetent	NN
cord-316534-ep7ezoko	481	79	,	,	,
cord-316534-ep7ezoko	481	80	first	first	JJ
cord-316534-ep7ezoko	481	81	generation	generation	NN
cord-316534-ep7ezoko	481	82	,	,	,
cord-316534-ep7ezoko	481	83	and	and	CC
cord-316534-ep7ezoko	481	84	helper	helper	NN
cord-316534-ep7ezoko	481	85	-	-	HYPH
cord-316534-ep7ezoko	481	86	dependent	dependent	JJ
cord-316534-ep7ezoko	481	87	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	88	vaccines	vaccine	NNS
cord-316534-ep7ezoko	481	89	Protection	Protection	NNP
cord-316534-ep7ezoko	481	90	against	against	IN
cord-316534-ep7ezoko	481	91	mucosal	mucosal	JJ
cord-316534-ep7ezoko	481	92	SHIV	SHIV	NNP
cord-316534-ep7ezoko	481	93	challenge	challenge	NN
cord-316534-ep7ezoko	481	94	by	by	IN
cord-316534-ep7ezoko	481	95	peptide	peptide	NN
cord-316534-ep7ezoko	481	96	and	and	CC
cord-316534-ep7ezoko	481	97	helper	helper	NN
cord-316534-ep7ezoko	481	98	-	-	HYPH
cord-316534-ep7ezoko	481	99	dependent	dependent	JJ
cord-316534-ep7ezoko	481	100	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	101	vaccines	vaccine	NNS
cord-316534-ep7ezoko	481	102	Effects	effect	NNS
cord-316534-ep7ezoko	481	103	of	of	IN
cord-316534-ep7ezoko	481	104	shielding	shield	VBG
cord-316534-ep7ezoko	481	105	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	106	vectors	vector	NNS
cord-316534-ep7ezoko	481	107	with	with	IN
cord-316534-ep7ezoko	481	108	polyethylene	polyethylene	NN
cord-316534-ep7ezoko	481	109	glycol	glycol	NN
cord-316534-ep7ezoko	481	110	(	(	-LRB-
cord-316534-ep7ezoko	481	111	PEG	PEG	NNP
cord-316534-ep7ezoko	481	112	)	)	-RRB-
cord-316534-ep7ezoko	481	113	on	on	IN
cord-316534-ep7ezoko	481	114	vector	vector	NN
cord-316534-ep7ezoko	481	115	-	-	HYPH
cord-316534-ep7ezoko	481	116	specific	specific	JJ
cord-316534-ep7ezoko	481	117	and	and	CC
cord-316534-ep7ezoko	481	118	vaccine	vaccine	NN
cord-316534-ep7ezoko	481	119	-	-	HYPH
cord-316534-ep7ezoko	481	120	mediated	mediate	VBN
cord-316534-ep7ezoko	481	121	immune	immune	JJ
cord-316534-ep7ezoko	481	122	responses	response	NNS
cord-316534-ep7ezoko	481	123	PEGylated	pegylate	VBN
cord-316534-ep7ezoko	481	124	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	125	for	for	IN
cord-316534-ep7ezoko	481	126	targeted	target	VBN
cord-316534-ep7ezoko	481	127	gene	gene	NN
cord-316534-ep7ezoko	481	128	therapy	therapy	NN
cord-316534-ep7ezoko	481	129	Development	Development	NNP
cord-316534-ep7ezoko	481	130	of	of	IN
cord-316534-ep7ezoko	481	131	PEGylated	pegylated	JJ
cord-316534-ep7ezoko	481	132	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	133	vector	vector	NN
cord-316534-ep7ezoko	481	134	with	with	IN
cord-316534-ep7ezoko	481	135	targeting	target	VBG
cord-316534-ep7ezoko	481	136	ligand	ligand	NN
cord-316534-ep7ezoko	481	137	Neutralizing	neutralize	VBG
cord-316534-ep7ezoko	481	138	antibody	antibody	NN
cord-316534-ep7ezoko	481	139	evasion	evasion	NN
cord-316534-ep7ezoko	481	140	ability	ability	NN
cord-316534-ep7ezoko	481	141	of	of	IN
cord-316534-ep7ezoko	481	142	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	143	vector	vector	NN
cord-316534-ep7ezoko	481	144	induced	induce	VBN
cord-316534-ep7ezoko	481	145	by	by	IN
cord-316534-ep7ezoko	481	146	the	the	DT
cord-316534-ep7ezoko	481	147	bioconjugation	bioconjugation	NN
cord-316534-ep7ezoko	481	148	of	of	IN
cord-316534-ep7ezoko	481	149	methoxypolyethylene	methoxypolyethylene	NNP
cord-316534-ep7ezoko	481	150	glycol	glycol	NNP
cord-316534-ep7ezoko	481	151	succinimidyl	succinimidyl	NNP
cord-316534-ep7ezoko	481	152	propionate	propionate	NNP
cord-316534-ep7ezoko	481	153	(	(	-LRB-
cord-316534-ep7ezoko	481	154	MPEG	MPEG	NNP
cord-316534-ep7ezoko	481	155	-	-	HYPH
cord-316534-ep7ezoko	481	156	SPA	SPA	NNP
cord-316534-ep7ezoko	481	157	)	)	-RRB-
cord-316534-ep7ezoko	481	158	PEGylated	pegylated	JJ
cord-316534-ep7ezoko	481	159	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	160	vectors	vector	NNS
cord-316534-ep7ezoko	481	161	containing	contain	VBG
cord-316534-ep7ezoko	481	162	RGD	RGD	NNP
cord-316534-ep7ezoko	481	163	peptides	peptide	NNS
cord-316534-ep7ezoko	481	164	on	on	IN
cord-316534-ep7ezoko	481	165	the	the	DT
cord-316534-ep7ezoko	481	166	tip	tip	NN
cord-316534-ep7ezoko	481	167	of	of	IN
cord-316534-ep7ezoko	481	168	PEG	PEG	NNP
cord-316534-ep7ezoko	481	169	show	show	VBP
cord-316534-ep7ezoko	481	170	high	high	JJ
cord-316534-ep7ezoko	481	171	transduction	transduction	NN
cord-316534-ep7ezoko	481	172	efficiency	efficiency	NN
cord-316534-ep7ezoko	481	173	and	and	CC
cord-316534-ep7ezoko	481	174	antibody	antibody	NN
cord-316534-ep7ezoko	481	175	evasion	evasion	NN
cord-316534-ep7ezoko	481	176	ability	ability	NN
cord-316534-ep7ezoko	481	177	Evaluation	Evaluation	NNP
cord-316534-ep7ezoko	481	178	of	of	IN
cord-316534-ep7ezoko	481	179	polyethylene	polyethylene	NN
cord-316534-ep7ezoko	481	180	glycol	glycol	NN
cord-316534-ep7ezoko	481	181	modification	modification	NN
cord-316534-ep7ezoko	481	182	of	of	IN
cord-316534-ep7ezoko	481	183	first	first	JJ
cord-316534-ep7ezoko	481	184	-	-	HYPH
cord-316534-ep7ezoko	481	185	generation	generation	NN
cord-316534-ep7ezoko	481	186	and	and	CC
cord-316534-ep7ezoko	481	187	helper	helper	NN
cord-316534-ep7ezoko	481	188	-	-	HYPH
cord-316534-ep7ezoko	481	189	dependent	dependent	JJ
cord-316534-ep7ezoko	481	190	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	191	vectors	vector	NNS
cord-316534-ep7ezoko	481	192	to	to	TO
cord-316534-ep7ezoko	481	193	reduce	reduce	VB
cord-316534-ep7ezoko	481	194	innate	innate	JJ
cord-316534-ep7ezoko	481	195	immune	immune	JJ
cord-316534-ep7ezoko	481	196	responses	response	NNS
cord-316534-ep7ezoko	481	197	PEGylated	pegylate	VBN
cord-316534-ep7ezoko	481	198	helper	helper	NN
cord-316534-ep7ezoko	481	199	-	-	HYPH
cord-316534-ep7ezoko	481	200	dependent	dependent	JJ
cord-316534-ep7ezoko	481	201	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	202	vectors	vector	NNS
cord-316534-ep7ezoko	481	203	:	:	:
cord-316534-ep7ezoko	481	204	highly	highly	RB
cord-316534-ep7ezoko	481	205	efficient	efficient	JJ
cord-316534-ep7ezoko	481	206	vectors	vector	NNS
cord-316534-ep7ezoko	481	207	with	with	IN
cord-316534-ep7ezoko	481	208	an	an	DT
cord-316534-ep7ezoko	481	209	enhanced	enhanced	JJ
cord-316534-ep7ezoko	481	210	safety	safety	NN
cord-316534-ep7ezoko	481	211	profile	profile	NN
cord-316534-ep7ezoko	481	212	Vaccination	vaccination	NN
cord-316534-ep7ezoko	481	213	against	against	IN
cord-316534-ep7ezoko	481	214	hepatitis	hepatitis	NN
cord-316534-ep7ezoko	481	215	C	C	NNP
cord-316534-ep7ezoko	481	216	virus	virus	NN
cord-316534-ep7ezoko	481	217	with	with	IN
cord-316534-ep7ezoko	481	218	dendritic	dendritic	JJ
cord-316534-ep7ezoko	481	219	cells	cell	NNS
cord-316534-ep7ezoko	481	220	transduced	transduce	VBN
cord-316534-ep7ezoko	481	221	with	with	IN
cord-316534-ep7ezoko	481	222	an	an	DT
cord-316534-ep7ezoko	481	223	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	481	224	encoding	encoding	NN
cord-316534-ep7ezoko	481	225	NS3	ns3	RB
cord-316534-ep7ezoko	481	226	protein	protein	NN
cord-316534-ep7ezoko	481	227	Cell	cell	NN
cord-316534-ep7ezoko	481	228	vehicle	vehicle	NN
cord-316534-ep7ezoko	481	229	targeting	target	VBG
cord-316534-ep7ezoko	481	230	strategies	strategy	NNS
cord-316534-ep7ezoko	481	231	Current	current	JJ
cord-316534-ep7ezoko	481	232	strategies	strategy	NNS
cord-316534-ep7ezoko	481	233	and	and	CC
cord-316534-ep7ezoko	481	234	future	future	JJ
cord-316534-ep7ezoko	481	235	directions	direction	NNS
cord-316534-ep7ezoko	481	236	for	for	IN
cord-316534-ep7ezoko	481	237	eluding	elude	VBG
cord-316534-ep7ezoko	481	238	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	239	vector	vector	NN
cord-316534-ep7ezoko	481	240	immunity	immunity	NN
cord-316534-ep7ezoko	481	241	Factors	factor	NNS
cord-316534-ep7ezoko	481	242	influencing	influence	VBG
cord-316534-ep7ezoko	481	243	therapeutic	therapeutic	JJ
cord-316534-ep7ezoko	481	244	efficacy	efficacy	NN
cord-316534-ep7ezoko	481	245	and	and	CC
cord-316534-ep7ezoko	481	246	the	the	DT
cord-316534-ep7ezoko	481	247	host	host	NN
cord-316534-ep7ezoko	481	248	immune	immune	JJ
cord-316534-ep7ezoko	481	249	response	response	NN
cord-316534-ep7ezoko	481	250	to	to	IN
cord-316534-ep7ezoko	481	251	helper	helper	NN
cord-316534-ep7ezoko	481	252	-	-	HYPH
cord-316534-ep7ezoko	481	253	dependent	dependent	JJ
cord-316534-ep7ezoko	481	254	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	481	255	gene	gene	NN
cord-316534-ep7ezoko	481	256	therapy	therapy	NN
cord-316534-ep7ezoko	481	257	in	in	IN
cord-316534-ep7ezoko	481	258	hemophilia	hemophilia	NNP
cord-316534-ep7ezoko	482	1	A	a	DT
cord-316534-ep7ezoko	482	2	mice	mice	NN
cord-316534-ep7ezoko	482	3	Elimination	elimination	NN
cord-316534-ep7ezoko	482	4	of	of	IN
cord-316534-ep7ezoko	482	5	innate	innate	JJ
cord-316534-ep7ezoko	482	6	immune	immune	JJ
cord-316534-ep7ezoko	482	7	responses	response	NNS
cord-316534-ep7ezoko	482	8	and	and	CC
cord-316534-ep7ezoko	482	9	liver	liver	NN
cord-316534-ep7ezoko	482	10	inflammation	inflammation	NN
cord-316534-ep7ezoko	482	11	by	by	IN
cord-316534-ep7ezoko	482	12	PEGylation	PEGylation	NNP
cord-316534-ep7ezoko	482	13	of	of	IN
cord-316534-ep7ezoko	482	14	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	482	15	vectors	vector	NNS
cord-316534-ep7ezoko	482	16	and	and	CC
cord-316534-ep7ezoko	482	17	methylprednisolone	methylprednisolone	NNP
cord-316534-ep7ezoko	482	18	Administration	Administration	NNP
cord-316534-ep7ezoko	482	19	of	of	IN
cord-316534-ep7ezoko	482	20	helper	helper	NN
cord-316534-ep7ezoko	482	21	-	-	HYPH
cord-316534-ep7ezoko	482	22	dependent	dependent	JJ
cord-316534-ep7ezoko	482	23	adenoviral	adenoviral	JJ
cord-316534-ep7ezoko	482	24	vectors	vector	NNS
cord-316534-ep7ezoko	482	25	and	and	CC
cord-316534-ep7ezoko	482	26	sequential	sequential	JJ
cord-316534-ep7ezoko	482	27	delivery	delivery	NN
cord-316534-ep7ezoko	482	28	of	of	IN
cord-316534-ep7ezoko	482	29	different	different	JJ
cord-316534-ep7ezoko	482	30	vector	vector	NN
cord-316534-ep7ezoko	482	31	serotype	serotype	NN
cord-316534-ep7ezoko	482	32	for	for	IN
cord-316534-ep7ezoko	482	33	long	long	JJ
cord-316534-ep7ezoko	482	34	-	-	HYPH
cord-316534-ep7ezoko	482	35	term	term	NN
cord-316534-ep7ezoko	482	36	liver	liver	NN
cord-316534-ep7ezoko	482	37	-	-	HYPH
cord-316534-ep7ezoko	482	38	directed	direct	VBN
cord-316534-ep7ezoko	482	39	gene	gene	NN
cord-316534-ep7ezoko	482	40	transfer	transfer	NN
cord-316534-ep7ezoko	482	41	in	in	IN
cord-316534-ep7ezoko	482	42	baboons	baboon	NNS
cord-316534-ep7ezoko	483	1	Baseline	baseline	JJ
cord-316534-ep7ezoko	483	2	Ad5	ad5	JJ
cord-316534-ep7ezoko	483	3	serostatus	serostatus	NN
cord-316534-ep7ezoko	483	4	does	do	VBZ
cord-316534-ep7ezoko	483	5	not	not	RB
cord-316534-ep7ezoko	483	6	predict	predict	VB
cord-316534-ep7ezoko	483	7	Ad5	ad5	CD
cord-316534-ep7ezoko	483	8	HIV	HIV	NNP
cord-316534-ep7ezoko	483	9	vaccine	vaccine	NN
cord-316534-ep7ezoko	483	10	-	-	HYPH
cord-316534-ep7ezoko	483	11	induced	induce	VBN
cord-316534-ep7ezoko	483	12	expansion	expansion	NN
cord-316534-ep7ezoko	483	13	of	of	IN
cord-316534-ep7ezoko	483	14	adenovirusspecific	adenovirusspecific	NNP
cord-316534-ep7ezoko	483	15	CD4	CD4	NNP
cord-316534-ep7ezoko	483	16	+	+	CC
cord-316534-ep7ezoko	483	17	T	T	NNP
cord-316534-ep7ezoko	483	18	cells	cell	NNS
cord-316534-ep7ezoko	483	19	Translational	translational	JJ
cord-316534-ep7ezoko	483	20	mini	mini	JJ
cord-316534-ep7ezoko	483	21	-	-	JJ
cord-316534-ep7ezoko	483	22	review	review	NN
cord-316534-ep7ezoko	483	23	series	series	NN
cord-316534-ep7ezoko	483	24	on	on	IN
cord-316534-ep7ezoko	483	25	vaccines	vaccine	NNS
cord-316534-ep7ezoko	483	26	for	for	IN
cord-316534-ep7ezoko	483	27	HIV	HIV	NNP
cord-316534-ep7ezoko	483	28	:	:	:
cord-316534-ep7ezoko	483	29	T	t	NN
cord-316534-ep7ezoko	483	30	lymphocyte	lymphocyte	NN
cord-316534-ep7ezoko	483	31	trafficking	trafficking	NN
cord-316534-ep7ezoko	483	32	and	and	CC
cord-316534-ep7ezoko	483	33	vaccine	vaccine	NN
cord-316534-ep7ezoko	483	34	-	-	HYPH
cord-316534-ep7ezoko	483	35	elicited	elicit	VBN
cord-316534-ep7ezoko	483	36	mucosal	mucosal	JJ
cord-316534-ep7ezoko	483	37	immunity	immunity	NN
cord-316534-ep7ezoko	483	38	Route	Route	NNP
cord-316534-ep7ezoko	483	39	of	of	IN
cord-316534-ep7ezoko	483	40	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	483	41	-	-	HYPH
cord-316534-ep7ezoko	483	42	based	base	VBN
cord-316534-ep7ezoko	483	43	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	483	44	vaccine	vaccine	NN
cord-316534-ep7ezoko	483	45	delivery	delivery	NN
cord-316534-ep7ezoko	483	46	impacts	impact	VBZ
cord-316534-ep7ezoko	483	47	the	the	DT
cord-316534-ep7ezoko	483	48	phenotype	phenotype	NN
cord-316534-ep7ezoko	483	49	and	and	CC
cord-316534-ep7ezoko	483	50	trafficking	trafficking	NN
cord-316534-ep7ezoko	483	51	of	of	IN
cord-316534-ep7ezoko	483	52	vaccine	vaccine	NN
cord-316534-ep7ezoko	483	53	-	-	HYPH
cord-316534-ep7ezoko	483	54	elicited	elicit	VBN
cord-316534-ep7ezoko	483	55	CD8	CD8	NNP
cord-316534-ep7ezoko	483	56	+	+	CC
cord-316534-ep7ezoko	483	57	T	T	NNP
cord-316534-ep7ezoko	483	58	lymphocytes	lymphocyte	NNS
cord-316534-ep7ezoko	483	59	Differential	differential	JJ
cord-316534-ep7ezoko	483	60	specificity	specificity	NN
cord-316534-ep7ezoko	483	61	and	and	CC
cord-316534-ep7ezoko	483	62	immunogenicity	immunogenicity	NN
cord-316534-ep7ezoko	483	63	of	of	IN
cord-316534-ep7ezoko	483	64	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	483	65	type	type	NN
cord-316534-ep7ezoko	483	66	5	5	CD
cord-316534-ep7ezoko	483	67	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	483	68	antibodies	antibody	NNS
cord-316534-ep7ezoko	483	69	elicited	elicit	VBN
cord-316534-ep7ezoko	483	70	by	by	IN
cord-316534-ep7ezoko	483	71	natural	natural	JJ
cord-316534-ep7ezoko	483	72	infection	infection	NN
cord-316534-ep7ezoko	483	73	or	or	CC
cord-316534-ep7ezoko	483	74	immunization	immunization	NN
cord-316534-ep7ezoko	483	75	Distribution	distribution	NN
cord-316534-ep7ezoko	483	76	of	of	IN
cord-316534-ep7ezoko	483	77	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	483	78	antibody	antibody	NN
cord-316534-ep7ezoko	483	79	in	in	IN
cord-316534-ep7ezoko	483	80	serum	serum	NN
cord-316534-ep7ezoko	483	81	,	,	,
cord-316534-ep7ezoko	483	82	nasopharynx	nasopharynx	NN
cord-316534-ep7ezoko	483	83	and	and	CC
cord-316534-ep7ezoko	483	84	alimentary	alimentary	JJ
cord-316534-ep7ezoko	483	85	tract	tract	NN
cord-316534-ep7ezoko	483	86	following	follow	VBG
cord-316534-ep7ezoko	483	87	segmental	segmental	JJ
cord-316534-ep7ezoko	483	88	immunization	immunization	NN
cord-316534-ep7ezoko	483	89	of	of	IN
cord-316534-ep7ezoko	483	90	lower	low	JJR
cord-316534-ep7ezoko	483	91	alimentary	alimentary	JJ
cord-316534-ep7ezoko	483	92	tract	tract	NN
cord-316534-ep7ezoko	483	93	with	with	IN
cord-316534-ep7ezoko	483	94	poliovaccine	poliovaccine	NN
cord-316534-ep7ezoko	483	95	Local	local	JJ
cord-316534-ep7ezoko	483	96	antibody	antibody	NN
cord-316534-ep7ezoko	483	97	response	response	NN
cord-316534-ep7ezoko	483	98	to	to	IN
cord-316534-ep7ezoko	483	99	experimental	experimental	JJ
cord-316534-ep7ezoko	483	100	poliovirus	poliovirus	NN
cord-316534-ep7ezoko	483	101	infection	infection	NN
cord-316534-ep7ezoko	483	102	in	in	IN
cord-316534-ep7ezoko	483	103	the	the	DT
cord-316534-ep7ezoko	483	104	central	central	JJ
cord-316534-ep7ezoko	483	105	nervous	nervous	JJ
cord-316534-ep7ezoko	483	106	system	system	NN
cord-316534-ep7ezoko	483	107	of	of	IN
cord-316534-ep7ezoko	483	108	rhesus	rhesu	NNS
cord-316534-ep7ezoko	483	109	monkeys	monkey	NNS
cord-316534-ep7ezoko	483	110	Strategies	strategy	NNS
cord-316534-ep7ezoko	483	111	for	for	IN
cord-316534-ep7ezoko	483	112	optimizing	optimize	VBG
cord-316534-ep7ezoko	483	113	targeting	targeting	NN
cord-316534-ep7ezoko	483	114	and	and	CC
cord-316534-ep7ezoko	483	115	delivery	delivery	NN
cord-316534-ep7ezoko	483	116	of	of	IN
cord-316534-ep7ezoko	483	117	mucosal	mucosal	JJ
cord-316534-ep7ezoko	483	118	HIV	HIV	NNP
cord-316534-ep7ezoko	483	119	vaccines	vaccine	NNS
cord-316534-ep7ezoko	483	120	Primary	Primary	NNP
cord-316534-ep7ezoko	483	121	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	483	122	infection	infection	NN
cord-316534-ep7ezoko	483	123	is	be	VBZ
cord-316534-ep7ezoko	483	124	associated	associate	VBN
cord-316534-ep7ezoko	483	125	with	with	IN
cord-316534-ep7ezoko	483	126	preferential	preferential	JJ
cord-316534-ep7ezoko	483	127	depletion	depletion	NN
cord-316534-ep7ezoko	483	128	of	of	IN
cord-316534-ep7ezoko	483	129	CD4	CD4	NNP
cord-316534-ep7ezoko	483	130	+	+	CC
cord-316534-ep7ezoko	483	131	T	t	NN
cord-316534-ep7ezoko	483	132	lymphocytes	lymphocyte	NNS
cord-316534-ep7ezoko	483	133	from	from	IN
cord-316534-ep7ezoko	483	134	effector	effector	NN
cord-316534-ep7ezoko	483	135	sites	site	NNS
cord-316534-ep7ezoko	483	136	in	in	IN
cord-316534-ep7ezoko	483	137	the	the	DT
cord-316534-ep7ezoko	483	138	gastrointestinal	gastrointestinal	JJ
cord-316534-ep7ezoko	483	139	tract	tract	NN
cord-316534-ep7ezoko	483	140	CD4	CD4	NNP
cord-316534-ep7ezoko	483	141	+	+	CC
cord-316534-ep7ezoko	483	142	T	t	NN
cord-316534-ep7ezoko	483	143	cell	cell	NN
cord-316534-ep7ezoko	483	144	depletion	depletion	NN
cord-316534-ep7ezoko	483	145	during	during	IN
cord-316534-ep7ezoko	483	146	all	all	DT
cord-316534-ep7ezoko	483	147	stages	stage	NNS
cord-316534-ep7ezoko	483	148	of	of	IN
cord-316534-ep7ezoko	483	149	HIV	HIV	NNP
cord-316534-ep7ezoko	483	150	disease	disease	NN
cord-316534-ep7ezoko	484	1	occurs	occur	VBZ
cord-316534-ep7ezoko	484	2	predominantly	predominantly	RB
cord-316534-ep7ezoko	484	3	in	in	IN
cord-316534-ep7ezoko	484	4	the	the	DT
cord-316534-ep7ezoko	484	5	gastrointestinal	gastrointestinal	JJ
cord-316534-ep7ezoko	484	6	tract	tract	NN
cord-316534-ep7ezoko	485	1	Mucosal	Mucosal	NNP
cord-316534-ep7ezoko	485	2	AIDS	AIDS	NNP
cord-316534-ep7ezoko	485	3	vaccine	vaccine	NN
cord-316534-ep7ezoko	485	4	reduces	reduce	VBZ
cord-316534-ep7ezoko	485	5	disease	disease	NN
cord-316534-ep7ezoko	485	6	and	and	CC
cord-316534-ep7ezoko	485	7	viral	viral	JJ
cord-316534-ep7ezoko	485	8	load	load	NN
cord-316534-ep7ezoko	485	9	in	in	IN
cord-316534-ep7ezoko	485	10	gut	gut	NN
cord-316534-ep7ezoko	485	11	reservoir	reservoir	NN
cord-316534-ep7ezoko	485	12	and	and	CC
cord-316534-ep7ezoko	485	13	blood	blood	NN
cord-316534-ep7ezoko	485	14	after	after	IN
cord-316534-ep7ezoko	485	15	mucosal	mucosal	JJ
cord-316534-ep7ezoko	485	16	infection	infection	NN
cord-316534-ep7ezoko	485	17	of	of	IN
cord-316534-ep7ezoko	485	18	macaques	macaque	NNS
cord-316534-ep7ezoko	485	19	Impact	Impact	NNP
cord-316534-ep7ezoko	485	20	of	of	IN
cord-316534-ep7ezoko	485	21	vaccineinduced	vaccineinduced	NNP
cord-316534-ep7ezoko	485	22	mucosal	mucosal	JJ
cord-316534-ep7ezoko	485	23	high	high	JJ
cord-316534-ep7ezoko	485	24	-	-	HYPH
cord-316534-ep7ezoko	485	25	avidity	avidity	NN
cord-316534-ep7ezoko	485	26	CD8	CD8	NNP
cord-316534-ep7ezoko	485	27	+	+	CC
cord-316534-ep7ezoko	485	28	CTLs	ctl	NNS
cord-316534-ep7ezoko	485	29	in	in	IN
cord-316534-ep7ezoko	485	30	delay	delay	NN
cord-316534-ep7ezoko	485	31	of	of	IN
cord-316534-ep7ezoko	485	32	AIDS	AIDS	NNP
cord-316534-ep7ezoko	485	33	viral	viral	JJ
cord-316534-ep7ezoko	485	34	dissemination	dissemination	NN
cord-316534-ep7ezoko	485	35	from	from	IN
cord-316534-ep7ezoko	485	36	mucosa	mucosa	JJ
cord-316534-ep7ezoko	485	37	A	a	DT
cord-316534-ep7ezoko	485	38	novel	novel	JJ
cord-316534-ep7ezoko	485	39	functional	functional	JJ
cord-316534-ep7ezoko	485	40	CTL	CTL	NNP
cord-316534-ep7ezoko	485	41	avidity	avidity	NN
cord-316534-ep7ezoko	485	42	/	/	SYM
cord-316534-ep7ezoko	485	43	activity	activity	NN
cord-316534-ep7ezoko	485	44	compartmentalization	compartmentalization	NN
cord-316534-ep7ezoko	485	45	to	to	IN
cord-316534-ep7ezoko	485	46	the	the	DT
cord-316534-ep7ezoko	485	47	site	site	NN
cord-316534-ep7ezoko	485	48	of	of	IN
cord-316534-ep7ezoko	485	49	mucosal	mucosal	JJ
cord-316534-ep7ezoko	485	50	immunization	immunization	NN
cord-316534-ep7ezoko	485	51	contributes	contribute	VBZ
cord-316534-ep7ezoko	485	52	to	to	IN
cord-316534-ep7ezoko	485	53	protection	protection	NN
cord-316534-ep7ezoko	485	54	of	of	IN
cord-316534-ep7ezoko	485	55	macaques	macaque	NNS
cord-316534-ep7ezoko	485	56	against	against	IN
cord-316534-ep7ezoko	485	57	simian	simian	JJ
cord-316534-ep7ezoko	485	58	/	/	SYM
cord-316534-ep7ezoko	485	59	human	human	JJ
cord-316534-ep7ezoko	485	60	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	485	61	viral	viral	JJ
cord-316534-ep7ezoko	485	62	depletion	depletion	NN
cord-316534-ep7ezoko	485	63	of	of	IN
cord-316534-ep7ezoko	485	64	mucosal	mucosal	JJ
cord-316534-ep7ezoko	485	65	CD4	CD4	NNP
cord-316534-ep7ezoko	485	66	+	+	CC
cord-316534-ep7ezoko	485	67	T	t	NN
cord-316534-ep7ezoko	485	68	cells	cell	NNS
cord-316534-ep7ezoko	486	1	Intranasal	intranasal	NN
cord-316534-ep7ezoko	486	2	immunization	immunization	NN
cord-316534-ep7ezoko	486	3	is	be	VBZ
cord-316534-ep7ezoko	486	4	superior	superior	JJ
cord-316534-ep7ezoko	486	5	to	to	IN
cord-316534-ep7ezoko	486	6	vaginal	vaginal	JJ
cord-316534-ep7ezoko	486	7	,	,	,
cord-316534-ep7ezoko	486	8	gastric	gastric	JJ
cord-316534-ep7ezoko	486	9	,	,	,
cord-316534-ep7ezoko	486	10	or	or	CC
cord-316534-ep7ezoko	486	11	rectal	rectal	JJ
cord-316534-ep7ezoko	486	12	immunization	immunization	NN
cord-316534-ep7ezoko	486	13	for	for	IN
cord-316534-ep7ezoko	486	14	the	the	DT
cord-316534-ep7ezoko	486	15	induction	induction	NN
cord-316534-ep7ezoko	486	16	of	of	IN
cord-316534-ep7ezoko	486	17	systemic	systemic	JJ
cord-316534-ep7ezoko	486	18	and	and	CC
cord-316534-ep7ezoko	486	19	mucosal	mucosal	JJ
cord-316534-ep7ezoko	486	20	anti	anti	JJ
cord-316534-ep7ezoko	486	21	-	-	JJ
cord-316534-ep7ezoko	486	22	HIV	hiv	JJ
cord-316534-ep7ezoko	486	23	antibody	antibody	NN
cord-316534-ep7ezoko	486	24	responses	response	NNS
cord-316534-ep7ezoko	487	1	Prophylactic	prophylactic	JJ
cord-316534-ep7ezoko	487	2	vaccine	vaccine	NN
cord-316534-ep7ezoko	487	3	for	for	IN
cord-316534-ep7ezoko	487	4	Hiv-1	Hiv-1	NNP
cord-316534-ep7ezoko	487	5	Comparison	Comparison	NNP
cord-316534-ep7ezoko	487	6	of	of	IN
cord-316534-ep7ezoko	487	7	the	the	DT
cord-316534-ep7ezoko	487	8	oral	oral	JJ
cord-316534-ep7ezoko	487	9	,	,	,
cord-316534-ep7ezoko	487	10	rectal	rectal	JJ
cord-316534-ep7ezoko	487	11	,	,	,
cord-316534-ep7ezoko	487	12	and	and	CC
cord-316534-ep7ezoko	487	13	vaginal	vaginal	JJ
cord-316534-ep7ezoko	487	14	immunization	immunization	NN
cord-316534-ep7ezoko	487	15	routes	route	NNS
cord-316534-ep7ezoko	487	16	for	for	IN
cord-316534-ep7ezoko	487	17	induction	induction	NN
cord-316534-ep7ezoko	487	18	of	of	IN
cord-316534-ep7ezoko	487	19	antibodies	antibody	NNS
cord-316534-ep7ezoko	487	20	in	in	IN
cord-316534-ep7ezoko	487	21	rectal	rectal	JJ
cord-316534-ep7ezoko	487	22	and	and	CC
cord-316534-ep7ezoko	487	23	genital	genital	JJ
cord-316534-ep7ezoko	487	24	tract	tract	JJ
cord-316534-ep7ezoko	487	25	secretions	secretion	NNS
cord-316534-ep7ezoko	487	26	of	of	IN
cord-316534-ep7ezoko	487	27	women	woman	NNS
cord-316534-ep7ezoko	487	28	Nucleocapsid	Nucleocapsid	NNP
cord-316534-ep7ezoko	487	29	protein	protein	NN
cord-316534-ep7ezoko	487	30	zinc	zinc	NN
cord-316534-ep7ezoko	487	31	-	-	HYPH
cord-316534-ep7ezoko	487	32	finger	finger	NN
cord-316534-ep7ezoko	487	33	mutants	mutant	NNS
cord-316534-ep7ezoko	487	34	of	of	IN
cord-316534-ep7ezoko	487	35	simian	simian	JJ
cord-316534-ep7ezoko	487	36	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	487	37	virus	virus	NN
cord-316534-ep7ezoko	487	38	strain	strain	NN
cord-316534-ep7ezoko	487	39	mne	mne	NNP
cord-316534-ep7ezoko	487	40	produce	produce	NN
cord-316534-ep7ezoko	487	41	virions	virion	NNS
cord-316534-ep7ezoko	487	42	that	that	WDT
cord-316534-ep7ezoko	487	43	are	be	VBP
cord-316534-ep7ezoko	487	44	replication	replication	NN
cord-316534-ep7ezoko	487	45	defective	defective	JJ
cord-316534-ep7ezoko	487	46	in	in	IN
cord-316534-ep7ezoko	487	47	vitro	vitro	FW
cord-316534-ep7ezoko	487	48	and	and	CC
cord-316534-ep7ezoko	487	49	in	in	IN
cord-316534-ep7ezoko	487	50	vivo	vivo	NN
cord-316534-ep7ezoko	488	1	An	an	DT
cord-316534-ep7ezoko	488	2	internalization	internalization	NN
cord-316534-ep7ezoko	488	3	signal	signal	NN
cord-316534-ep7ezoko	488	4	in	in	IN
cord-316534-ep7ezoko	488	5	the	the	DT
cord-316534-ep7ezoko	488	6	simian	simian	JJ
cord-316534-ep7ezoko	488	7	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	488	8	virus	virus	NN
cord-316534-ep7ezoko	488	9	transmembrane	transmembrane	NN
cord-316534-ep7ezoko	488	10	protein	protein	NN
cord-316534-ep7ezoko	488	11	cytoplasmic	cytoplasmic	JJ
cord-316534-ep7ezoko	488	12	domain	domain	NN
cord-316534-ep7ezoko	488	13	modulates	modulate	VBZ
cord-316534-ep7ezoko	488	14	expression	expression	NN
cord-316534-ep7ezoko	488	15	of	of	IN
cord-316534-ep7ezoko	488	16	envelope	envelope	NN
cord-316534-ep7ezoko	488	17	glycoproteins	glycoprotein	NNS
cord-316534-ep7ezoko	488	18	on	on	IN
cord-316534-ep7ezoko	488	19	the	the	DT
cord-316534-ep7ezoko	488	20	cell	cell	NN
cord-316534-ep7ezoko	488	21	surface	surface	NN
cord-316534-ep7ezoko	488	22	Broadly	broadly	RB
cord-316534-ep7ezoko	488	23	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	488	24	monoclonal	monoclonal	JJ
cord-316534-ep7ezoko	488	25	antibodies	antibody	NNS
cord-316534-ep7ezoko	488	26	2F5	2f5	CD
cord-316534-ep7ezoko	488	27	and	and	CC
cord-316534-ep7ezoko	488	28	4E10	4e10	CD
cord-316534-ep7ezoko	488	29	directed	direct	VBD
cord-316534-ep7ezoko	488	30	against	against	IN
cord-316534-ep7ezoko	488	31	the	the	DT
cord-316534-ep7ezoko	488	32	human	human	JJ
cord-316534-ep7ezoko	488	33	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	488	34	virus	virus	NN
cord-316534-ep7ezoko	488	35	type	type	NN
cord-316534-ep7ezoko	488	36	1	1	CD
cord-316534-ep7ezoko	488	37	gp41	gp41	NN
cord-316534-ep7ezoko	488	38	membrane	membrane	NN
cord-316534-ep7ezoko	488	39	-	-	HYPH
cord-316534-ep7ezoko	488	40	proximal	proximal	JJ
cord-316534-ep7ezoko	488	41	external	external	JJ
cord-316534-ep7ezoko	488	42	region	region	NN
cord-316534-ep7ezoko	488	43	protect	protect	VBP
cord-316534-ep7ezoko	488	44	against	against	IN
cord-316534-ep7ezoko	488	45	mucosal	mucosal	JJ
cord-316534-ep7ezoko	488	46	challenge	challenge	NN
cord-316534-ep7ezoko	488	47	by	by	IN
cord-316534-ep7ezoko	488	48	simian	simian	JJ
cord-316534-ep7ezoko	488	49	-	-	HYPH
cord-316534-ep7ezoko	488	50	human	human	JJ
cord-316534-ep7ezoko	488	51	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	488	52	virus	virus	NN
cord-316534-ep7ezoko	488	53	SHIVBa	SHIVBa	NNPS
cord-316534-ep7ezoko	488	54	-	-	HYPH
cord-316534-ep7ezoko	488	55	L	L	NNP
cord-316534-ep7ezoko	488	56	Immunogenicity	Immunogenicity	NNP
cord-316534-ep7ezoko	488	57	of	of	IN
cord-316534-ep7ezoko	488	58	recombinant	recombinant	JJ
cord-316534-ep7ezoko	488	59	human	human	JJ
cord-316534-ep7ezoko	488	60	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	488	61	-	-	HYPH
cord-316534-ep7ezoko	488	62	human	human	JJ
cord-316534-ep7ezoko	488	63	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	488	64	virus	virus	NN
cord-316534-ep7ezoko	488	65	vaccines	vaccine	NNS
cord-316534-ep7ezoko	488	66	in	in	IN
cord-316534-ep7ezoko	488	67	chimpanzees	chimpanzee	NNS
cord-316534-ep7ezoko	488	68	Long	long	JJ
cord-316534-ep7ezoko	488	69	-	-	HYPH
cord-316534-ep7ezoko	488	70	term	term	NN
cord-316534-ep7ezoko	488	71	protection	protection	NN
cord-316534-ep7ezoko	488	72	of	of	IN
cord-316534-ep7ezoko	488	73	chimpanzees	chimpanzee	NNS
cord-316534-ep7ezoko	488	74	against	against	IN
cord-316534-ep7ezoko	488	75	high	high	JJ
cord-316534-ep7ezoko	488	76	-	-	HYPH
cord-316534-ep7ezoko	488	77	dose	dose	NN
cord-316534-ep7ezoko	488	78	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	488	79	challenge	challenge	NN
cord-316534-ep7ezoko	488	80	induced	induce	VBN
cord-316534-ep7ezoko	488	81	by	by	IN
cord-316534-ep7ezoko	488	82	immunization	immunization	NN
cord-316534-ep7ezoko	488	83	Protection	Protection	NNP
cord-316534-ep7ezoko	488	84	against	against	IN
cord-316534-ep7ezoko	488	85	mucosal	mucosal	JJ
cord-316534-ep7ezoko	488	86	simian	simian	JJ
cord-316534-ep7ezoko	488	87	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	488	88	virus	virus	NN
cord-316534-ep7ezoko	488	89	SIV(mac251	SIV(mac251	NNP
cord-316534-ep7ezoko	488	90	)	)	-RRB-
cord-316534-ep7ezoko	488	91	challenge	challenge	NN
cord-316534-ep7ezoko	488	92	by	by	IN
cord-316534-ep7ezoko	488	93	using	use	VBG
cord-316534-ep7ezoko	488	94	replicating	replicate	VBG
cord-316534-ep7ezoko	488	95	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	488	96	-	-	HYPH
cord-316534-ep7ezoko	488	97	SIV	SIV	NNP
cord-316534-ep7ezoko	488	98	multigene	multigene	JJ
cord-316534-ep7ezoko	488	99	vaccine	vaccine	NN
cord-316534-ep7ezoko	488	100	priming	priming	NN
cord-316534-ep7ezoko	488	101	and	and	CC
cord-316534-ep7ezoko	488	102	subunit	subunit	NN
cord-316534-ep7ezoko	488	103	boosting	boost	VBG
cord-316534-ep7ezoko	488	104	Evaluation	Evaluation	NNP
cord-316534-ep7ezoko	488	105	of	of	IN
cord-316534-ep7ezoko	488	106	combination	combination	NN
cord-316534-ep7ezoko	488	107	DNA	dna	NN
cord-316534-ep7ezoko	488	108	/	/	SYM
cord-316534-ep7ezoko	488	109	replication	replication	NN
cord-316534-ep7ezoko	488	110	-	-	HYPH
cord-316534-ep7ezoko	488	111	competent	competent	JJ
cord-316534-ep7ezoko	488	112	Ad	Ad	NNP
cord-316534-ep7ezoko	488	113	-	-	HYPH
cord-316534-ep7ezoko	488	114	SIV	SIV	NNP
cord-316534-ep7ezoko	488	115	recombinant	recombinant	JJ
cord-316534-ep7ezoko	488	116	immunization	immunization	NN
cord-316534-ep7ezoko	488	117	regimens	regimen	NNS
cord-316534-ep7ezoko	488	118	in	in	IN
cord-316534-ep7ezoko	488	119	rhesus	rhesus	NN
cord-316534-ep7ezoko	488	120	macaques	macaque	NNS
cord-316534-ep7ezoko	488	121	Novel	Novel	NNP
cord-316534-ep7ezoko	488	122	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	488	123	vaccine	vaccine	NN
cord-316534-ep7ezoko	488	124	vectors	vector	NNS
cord-316534-ep7ezoko	488	125	based	base	VBN
cord-316534-ep7ezoko	488	126	on	on	IN
cord-316534-ep7ezoko	488	127	the	the	DT
cord-316534-ep7ezoko	488	128	enteric	enteric	JJ
cord-316534-ep7ezoko	488	129	-	-	HYPH
cord-316534-ep7ezoko	488	130	tropic	tropic	NN
cord-316534-ep7ezoko	488	131	serotype	serotype	NN
cord-316534-ep7ezoko	488	132	41	41	CD
cord-316534-ep7ezoko	488	133	Human	human	JJ
cord-316534-ep7ezoko	488	134	viral	viral	JJ
cord-316534-ep7ezoko	488	135	gastroenteritis	gastroenteritis	NN
cord-316534-ep7ezoko	488	136	Unique	unique	JJ
cord-316534-ep7ezoko	488	137	physicochemical	physicochemical	JJ
cord-316534-ep7ezoko	488	138	properties	property	NNS
cord-316534-ep7ezoko	488	139	of	of	IN
cord-316534-ep7ezoko	488	140	human	human	JJ
cord-316534-ep7ezoko	488	141	enteric	enteric	JJ
cord-316534-ep7ezoko	488	142	Ad41	Ad41	NNP
cord-316534-ep7ezoko	488	143	responsible	responsible	JJ
cord-316534-ep7ezoko	488	144	for	for	IN
cord-316534-ep7ezoko	488	145	its	-PRON-	PRP$
cord-316534-ep7ezoko	488	146	survival	survival	NN
cord-316534-ep7ezoko	488	147	and	and	CC
cord-316534-ep7ezoko	488	148	replication	replication	NN
cord-316534-ep7ezoko	488	149	in	in	IN
cord-316534-ep7ezoko	488	150	the	the	DT
cord-316534-ep7ezoko	488	151	gastrointestinal	gastrointestinal	JJ
cord-316534-ep7ezoko	488	152	tract	tract	NN
cord-316534-ep7ezoko	488	153	Human	human	JJ
cord-316534-ep7ezoko	488	154	enteric	enteric	JJ
cord-316534-ep7ezoko	488	155	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	488	156	type	type	NN
cord-316534-ep7ezoko	488	157	41	41	CD
cord-316534-ep7ezoko	489	1	(	(	-LRB-
cord-316534-ep7ezoko	489	2	Tak	Tak	NNP
cord-316534-ep7ezoko	489	3	)	)	-RRB-
cord-316534-ep7ezoko	489	4	contains	contain	VBZ
cord-316534-ep7ezoko	489	5	a	a	DT
cord-316534-ep7ezoko	489	6	second	second	JJ
cord-316534-ep7ezoko	489	7	fiber	fiber	NN
cord-316534-ep7ezoko	489	8	protein	protein	NN
cord-316534-ep7ezoko	489	9	gene	gene	NN
cord-316534-ep7ezoko	489	10	Adenovirus	Adenovirus	NNP
cord-316534-ep7ezoko	489	11	-	-	HYPH
cord-316534-ep7ezoko	489	12	based	base	VBN
cord-316534-ep7ezoko	489	13	primeboost	primeboost	NN
cord-316534-ep7ezoko	489	14	immunization	immunization	NN
cord-316534-ep7ezoko	489	15	for	for	IN
cord-316534-ep7ezoko	489	16	rapid	rapid	JJ
cord-316534-ep7ezoko	489	17	vaccination	vaccination	NN
cord-316534-ep7ezoko	489	18	against	against	IN
cord-316534-ep7ezoko	489	19	anthrax	anthrax	NN
cord-316534-ep7ezoko	489	20	Development	Development	NNP
cord-316534-ep7ezoko	489	21	of	of	IN
cord-316534-ep7ezoko	489	22	a	a	DT
cord-316534-ep7ezoko	489	23	preventive	preventive	JJ
cord-316534-ep7ezoko	489	24	vaccine	vaccine	NN
cord-316534-ep7ezoko	489	25	for	for	IN
cord-316534-ep7ezoko	489	26	Ebola	Ebola	NNP
cord-316534-ep7ezoko	489	27	virus	virus	NN
cord-316534-ep7ezoko	489	28	infection	infection	NN
cord-316534-ep7ezoko	489	29	in	in	IN
cord-316534-ep7ezoko	489	30	primates	primate	NNS
cord-316534-ep7ezoko	489	31	Adenoviral	Adenoviral	NNP
cord-316534-ep7ezoko	489	32	expression	expression	NN
cord-316534-ep7ezoko	489	33	of	of	IN
cord-316534-ep7ezoko	489	34	a	a	DT
cord-316534-ep7ezoko	489	35	truncated	truncated	JJ
cord-316534-ep7ezoko	489	36	S1	s1	NN
cord-316534-ep7ezoko	489	37	subunit	subunit	NN
cord-316534-ep7ezoko	489	38	of	of	IN
cord-316534-ep7ezoko	489	39	SARS	SARS	NNP
cord-316534-ep7ezoko	489	40	-	-	HYPH
cord-316534-ep7ezoko	489	41	CoV	CoV	NNP
cord-316534-ep7ezoko	489	42	spike	spike	NN
cord-316534-ep7ezoko	489	43	protein	protein	NN
cord-316534-ep7ezoko	489	44	results	result	NNS
cord-316534-ep7ezoko	489	45	in	in	IN
cord-316534-ep7ezoko	489	46	specific	specific	JJ
cord-316534-ep7ezoko	489	47	humoral	humoral	JJ
cord-316534-ep7ezoko	489	48	immune	immune	JJ
cord-316534-ep7ezoko	489	49	responses	response	NNS
cord-316534-ep7ezoko	489	50	against	against	IN
cord-316534-ep7ezoko	489	51	SARS	SARS	NNP
cord-316534-ep7ezoko	489	52	-	-	HYPH
cord-316534-ep7ezoko	489	53	CoV	CoV	NNP
cord-316534-ep7ezoko	489	54	in	in	IN
cord-316534-ep7ezoko	489	55	rats	rat	NNS
cord-316534-ep7ezoko	489	56	Adenoviruses	adenovirus	NNS
cord-316534-ep7ezoko	489	57	as	as	IN
cord-316534-ep7ezoko	489	58	vectors	vector	NNS
cord-316534-ep7ezoko	489	59	for	for	IN
cord-316534-ep7ezoko	489	60	HIV	HIV	NNP
cord-316534-ep7ezoko	489	61	vaccines	vaccine	NNS
cord-316534-ep7ezoko	489	62	Characterization	characterization	NN
cord-316534-ep7ezoko	489	63	of	of	IN
cord-316534-ep7ezoko	489	64	a	a	DT
cord-316534-ep7ezoko	489	65	permissive	permissive	JJ
cord-316534-ep7ezoko	489	66	epitope	epitope	NN
cord-316534-ep7ezoko	489	67	insertion	insertion	NN
cord-316534-ep7ezoko	489	68	site	site	NN
cord-316534-ep7ezoko	489	69	in	in	IN
cord-316534-ep7ezoko	489	70	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	489	71	hexon	hexon	NN
cord-316534-ep7ezoko	489	72	Challenges	challenge	NNS
cord-316534-ep7ezoko	489	73	for	for	IN
cord-316534-ep7ezoko	489	74	structure	structure	NN
cord-316534-ep7ezoko	489	75	-	-	HYPH
cord-316534-ep7ezoko	489	76	based	base	VBN
cord-316534-ep7ezoko	489	77	HIV	HIV	NNP
cord-316534-ep7ezoko	489	78	vaccine	vaccine	NN
cord-316534-ep7ezoko	489	79	design	design	NN
cord-316534-ep7ezoko	489	80	Designing	design	VBG
cord-316534-ep7ezoko	489	81	immunogens	immunogen	NNS
cord-316534-ep7ezoko	489	82	to	to	TO
cord-316534-ep7ezoko	489	83	elicit	elicit	VB
cord-316534-ep7ezoko	489	84	broadly	broadly	RB
cord-316534-ep7ezoko	489	85	neutralizing	neutralize	VBG
cord-316534-ep7ezoko	489	86	antibodies	antibody	NNS
cord-316534-ep7ezoko	489	87	to	to	IN
cord-316534-ep7ezoko	489	88	the	the	DT
cord-316534-ep7ezoko	489	89	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	489	90	envelope	envelope	NN
cord-316534-ep7ezoko	489	91	glycoprotein	glycoprotein	NN
cord-316534-ep7ezoko	489	92	Rational	rational	JJ
cord-316534-ep7ezoko	489	93	antibody	antibody	NN
cord-316534-ep7ezoko	489	94	-	-	HYPH
cord-316534-ep7ezoko	489	95	based	base	VBN
cord-316534-ep7ezoko	489	96	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	489	97	vaccine	vaccine	NN
cord-316534-ep7ezoko	489	98	design	design	NN
cord-316534-ep7ezoko	489	99	:	:	:
cord-316534-ep7ezoko	489	100	current	current	JJ
cord-316534-ep7ezoko	489	101	approaches	approach	NNS
cord-316534-ep7ezoko	489	102	and	and	CC
cord-316534-ep7ezoko	489	103	future	future	JJ
cord-316534-ep7ezoko	489	104	directions	direction	NNS
cord-316534-ep7ezoko	489	105	Molecular	molecular	JJ
cord-316534-ep7ezoko	489	106	architecture	architecture	NN
cord-316534-ep7ezoko	489	107	of	of	IN
cord-316534-ep7ezoko	489	108	native	native	JJ
cord-316534-ep7ezoko	489	109	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	489	110	gp120	gp120	NNP
cord-316534-ep7ezoko	489	111	trimers	trimer	VBZ
cord-316534-ep7ezoko	489	112	Structural	structural	JJ
cord-316534-ep7ezoko	489	113	definition	definition	NN
cord-316534-ep7ezoko	489	114	of	of	IN
cord-316534-ep7ezoko	489	115	a	a	DT
cord-316534-ep7ezoko	489	116	conserved	conserve	VBN
cord-316534-ep7ezoko	489	117	neutralization	neutralization	NN
cord-316534-ep7ezoko	489	118	epitope	epitope	NN
cord-316534-ep7ezoko	489	119	on	on	IN
cord-316534-ep7ezoko	490	1	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	490	2	gp120	gp120	NNP
cord-316534-ep7ezoko	491	1	One	one	CD
cord-316534-ep7ezoko	491	2	step	step	NN
cord-316534-ep7ezoko	491	3	forwards	forwards	RB
cord-316534-ep7ezoko	491	4	,	,	,
cord-316534-ep7ezoko	491	5	one	one	CD
cord-316534-ep7ezoko	491	6	step	step	NN
cord-316534-ep7ezoko	491	7	back	back	RP
cord-316534-ep7ezoko	491	8	Prospects	prospect	NNS
cord-316534-ep7ezoko	491	9	for	for	IN
cord-316534-ep7ezoko	491	10	vaccine	vaccine	NN
cord-316534-ep7ezoko	491	11	protection	protection	NN
cord-316534-ep7ezoko	491	12	against	against	IN
cord-316534-ep7ezoko	491	13	HIV-1	HIV-1	NNP
cord-316534-ep7ezoko	491	14	infection	infection	NN
cord-316534-ep7ezoko	491	15	and	and	CC
cord-316534-ep7ezoko	491	16	AIDS	AIDS	NNP
cord-316534-ep7ezoko	491	17	Modification	Modification	NNP
cord-316534-ep7ezoko	491	18	to	to	IN
cord-316534-ep7ezoko	491	19	the	the	DT
cord-316534-ep7ezoko	491	20	capsid	capsid	NN
cord-316534-ep7ezoko	491	21	of	of	IN
cord-316534-ep7ezoko	491	22	the	the	DT
cord-316534-ep7ezoko	491	23	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	24	vector	vector	NN
cord-316534-ep7ezoko	491	25	that	that	WDT
cord-316534-ep7ezoko	491	26	enhances	enhance	VBZ
cord-316534-ep7ezoko	491	27	dendritic	dendritic	JJ
cord-316534-ep7ezoko	491	28	cell	cell	NN
cord-316534-ep7ezoko	491	29	infection	infection	NN
cord-316534-ep7ezoko	491	30	and	and	CC
cord-316534-ep7ezoko	491	31	transgene	transgene	NN
cord-316534-ep7ezoko	491	32	-	-	HYPH
cord-316534-ep7ezoko	491	33	specific	specific	JJ
cord-316534-ep7ezoko	491	34	cellular	cellular	JJ
cord-316534-ep7ezoko	491	35	immune	immune	JJ
cord-316534-ep7ezoko	491	36	responses	response	NNS
cord-316534-ep7ezoko	491	37	Protection	Protection	NNP
cord-316534-ep7ezoko	491	38	against	against	IN
cord-316534-ep7ezoko	491	39	P.	P.	NNP
cord-316534-ep7ezoko	491	40	aeruginosa	aeruginosa	NN
cord-316534-ep7ezoko	491	41	with	with	IN
cord-316534-ep7ezoko	491	42	an	an	DT
cord-316534-ep7ezoko	491	43	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	44	vector	vector	NN
cord-316534-ep7ezoko	491	45	containing	contain	VBG
cord-316534-ep7ezoko	491	46	an	an	DT
cord-316534-ep7ezoko	491	47	OprF	OprF	NNP
cord-316534-ep7ezoko	491	48	epitope	epitope	NN
cord-316534-ep7ezoko	491	49	in	in	IN
cord-316534-ep7ezoko	491	50	the	the	DT
cord-316534-ep7ezoko	491	51	capsid	capsid	JJ
cord-316534-ep7ezoko	491	52	Optimization	optimization	NN
cord-316534-ep7ezoko	491	53	of	of	IN
cord-316534-ep7ezoko	491	54	capsid	capsid	RB
cord-316534-ep7ezoko	491	55	-	-	HYPH
cord-316534-ep7ezoko	491	56	incorporated	incorporate	VBN
cord-316534-ep7ezoko	491	57	antigens	antigen	NNS
cord-316534-ep7ezoko	491	58	for	for	IN
cord-316534-ep7ezoko	491	59	a	a	DT
cord-316534-ep7ezoko	491	60	novel	novel	JJ
cord-316534-ep7ezoko	491	61	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	62	vaccine	vaccine	NN
cord-316534-ep7ezoko	491	63	approach	approach	NN
cord-316534-ep7ezoko	491	64	Epitopes	Epitopes	NNP
cord-316534-ep7ezoko	491	65	expressed	express	VBD
cord-316534-ep7ezoko	491	66	in	in	IN
cord-316534-ep7ezoko	491	67	different	different	JJ
cord-316534-ep7ezoko	491	68	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	69	capsid	capsid	NN
cord-316534-ep7ezoko	491	70	proteins	protein	NNS
cord-316534-ep7ezoko	491	71	induce	induce	VBP
cord-316534-ep7ezoko	491	72	different	different	JJ
cord-316534-ep7ezoko	491	73	levels	level	NNS
cord-316534-ep7ezoko	491	74	of	of	IN
cord-316534-ep7ezoko	491	75	epitope	epitope	NN
cord-316534-ep7ezoko	491	76	-	-	HYPH
cord-316534-ep7ezoko	491	77	specific	specific	JJ
cord-316534-ep7ezoko	491	78	immunity	immunity	NN
cord-316534-ep7ezoko	491	79	Expression	expression	NN
cord-316534-ep7ezoko	491	80	of	of	IN
cord-316534-ep7ezoko	491	81	a	a	DT
cord-316534-ep7ezoko	491	82	foreign	foreign	JJ
cord-316534-ep7ezoko	491	83	epitope	epitope	NN
cord-316534-ep7ezoko	491	84	on	on	IN
cord-316534-ep7ezoko	491	85	the	the	DT
cord-316534-ep7ezoko	491	86	surface	surface	NN
cord-316534-ep7ezoko	491	87	of	of	IN
cord-316534-ep7ezoko	491	88	the	the	DT
cord-316534-ep7ezoko	491	89	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	90	hexon	hexon	NNP
cord-316534-ep7ezoko	491	91	Identification	identification	NN
cord-316534-ep7ezoko	491	92	of	of	IN
cord-316534-ep7ezoko	491	93	sites	site	NNS
cord-316534-ep7ezoko	491	94	in	in	IN
cord-316534-ep7ezoko	491	95	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	96	hexon	hexon	NN
cord-316534-ep7ezoko	491	97	for	for	IN
cord-316534-ep7ezoko	491	98	foreign	foreign	JJ
cord-316534-ep7ezoko	491	99	peptide	peptide	NN
cord-316534-ep7ezoko	491	100	incorporation	incorporation	NN
cord-316534-ep7ezoko	491	101	Structural	structural	JJ
cord-316534-ep7ezoko	491	102	and	and	CC
cord-316534-ep7ezoko	491	103	phylogenetic	phylogenetic	JJ
cord-316534-ep7ezoko	491	104	analysis	analysis	NN
cord-316534-ep7ezoko	491	105	of	of	IN
cord-316534-ep7ezoko	491	106	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	107	hexons	hexon	NNS
cord-316534-ep7ezoko	491	108	by	by	IN
cord-316534-ep7ezoko	491	109	use	use	NN
cord-316534-ep7ezoko	491	110	of	of	IN
cord-316534-ep7ezoko	491	111	high	high	JJ
cord-316534-ep7ezoko	491	112	-	-	HYPH
cord-316534-ep7ezoko	491	113	resolution	resolution	NN
cord-316534-ep7ezoko	491	114	X	x	NN
cord-316534-ep7ezoko	491	115	-	-	NN
cord-316534-ep7ezoko	491	116	ray	ray	NN
cord-316534-ep7ezoko	491	117	crystallographic	crystallographic	JJ
cord-316534-ep7ezoko	491	118	,	,	,
cord-316534-ep7ezoko	491	119	molecular	molecular	JJ
cord-316534-ep7ezoko	491	120	modeling	modeling	NN
cord-316534-ep7ezoko	491	121	,	,	,
cord-316534-ep7ezoko	491	122	and	and	CC
cord-316534-ep7ezoko	491	123	sequence	sequence	NN
cord-316534-ep7ezoko	491	124	-	-	HYPH
cord-316534-ep7ezoko	491	125	based	base	VBN
cord-316534-ep7ezoko	491	126	methods	method	NNS
cord-316534-ep7ezoko	491	127	Protective	protective	JJ
cord-316534-ep7ezoko	491	128	immunity	immunity	NN
cord-316534-ep7ezoko	491	129	to	to	IN
cord-316534-ep7ezoko	491	130	pseudomonas	pseudomonas	NNP
cord-316534-ep7ezoko	491	131	aeruginosa	aeruginosa	NN
cord-316534-ep7ezoko	491	132	induced	induce	VBN
cord-316534-ep7ezoko	491	133	with	with	IN
cord-316534-ep7ezoko	491	134	a	a	DT
cord-316534-ep7ezoko	491	135	capsid	capsid	RB
cord-316534-ep7ezoko	491	136	-	-	HYPH
cord-316534-ep7ezoko	491	137	modified	modify	VBN
cord-316534-ep7ezoko	491	138	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	491	139	expressing	express	VBG
cord-316534-ep7ezoko	491	140	P.	P.	NNP
cord-316534-ep7ezoko	491	141	aeruginosa	aeruginosa	NNP
cord-316534-ep7ezoko	492	1	OprF	OprF	NNP
cord-316534-ep7ezoko	492	2	RGD	RGD	NNP
cord-316534-ep7ezoko	492	3	inclusion	inclusion	NN
cord-316534-ep7ezoko	492	4	in	in	IN
cord-316534-ep7ezoko	492	5	the	the	DT
cord-316534-ep7ezoko	492	6	hexon	hexon	NNP
cord-316534-ep7ezoko	492	7	monomer	monomer	NNP
cord-316534-ep7ezoko	492	8	provides	provide	VBZ
cord-316534-ep7ezoko	492	9	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	492	10	type	type	NN
cord-316534-ep7ezoko	492	11	5-based	5-based	CD
cord-316534-ep7ezoko	492	12	vectors	vector	NNS
cord-316534-ep7ezoko	492	13	with	with	IN
cord-316534-ep7ezoko	492	14	a	a	DT
cord-316534-ep7ezoko	492	15	fiber	fiber	NN
cord-316534-ep7ezoko	492	16	knob	knob	NN
cord-316534-ep7ezoko	492	17	-	-	HYPH
cord-316534-ep7ezoko	492	18	independent	independent	JJ
cord-316534-ep7ezoko	492	19	pathway	pathway	NN
cord-316534-ep7ezoko	492	20	for	for	IN
cord-316534-ep7ezoko	492	21	infection	infection	NN
cord-316534-ep7ezoko	492	22	Adenovirus	Adenovirus	NNP
cord-316534-ep7ezoko	492	23	type	type	NN
cord-316534-ep7ezoko	492	24	5	5	CD
cord-316534-ep7ezoko	492	25	with	with	IN
cord-316534-ep7ezoko	492	26	modified	modify	VBN
cord-316534-ep7ezoko	492	27	hexons	hexon	NNS
cord-316534-ep7ezoko	492	28	induces	induce	VBZ
cord-316534-ep7ezoko	492	29	robust	robust	JJ
cord-316534-ep7ezoko	492	30	transgene	transgene	NN
cord-316534-ep7ezoko	492	31	-	-	HYPH
cord-316534-ep7ezoko	492	32	specific	specific	JJ
cord-316534-ep7ezoko	492	33	immune	immune	JJ
cord-316534-ep7ezoko	492	34	responses	response	NNS
cord-316534-ep7ezoko	492	35	in	in	IN
cord-316534-ep7ezoko	492	36	mice	mouse	NNS
cord-316534-ep7ezoko	492	37	with	with	IN
cord-316534-ep7ezoko	492	38	pre	pre	JJ
cord-316534-ep7ezoko	492	39	-	-	JJ
cord-316534-ep7ezoko	492	40	existing	existing	JJ
cord-316534-ep7ezoko	492	41	immunity	immunity	NN
cord-316534-ep7ezoko	492	42	against	against	IN
cord-316534-ep7ezoko	492	43	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	492	44	type	type	NN
cord-316534-ep7ezoko	492	45	5	5	CD
cord-316534-ep7ezoko	492	46	Structure	structure	NN
cord-316534-ep7ezoko	492	47	and	and	CC
cord-316534-ep7ezoko	492	48	mechanistic	mechanistic	JJ
cord-316534-ep7ezoko	492	49	analysis	analysis	NN
cord-316534-ep7ezoko	492	50	of	of	IN
cord-316534-ep7ezoko	492	51	the	the	DT
cord-316534-ep7ezoko	492	52	anti	anti	JJ
cord-316534-ep7ezoko	492	53	-	-	JJ
cord-316534-ep7ezoko	492	54	human	human	JJ
cord-316534-ep7ezoko	492	55	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	492	56	virus	virus	NN
cord-316534-ep7ezoko	492	57	type	type	NN
cord-316534-ep7ezoko	492	58	1	1	CD
cord-316534-ep7ezoko	492	59	antibody	antibody	NN
cord-316534-ep7ezoko	492	60	2F5	2f5	CD
cord-316534-ep7ezoko	492	61	in	in	IN
cord-316534-ep7ezoko	492	62	complex	complex	NN
cord-316534-ep7ezoko	492	63	with	with	IN
cord-316534-ep7ezoko	492	64	its	-PRON-	PRP$
cord-316534-ep7ezoko	492	65	gp41	gp41	NNP
cord-316534-ep7ezoko	492	66	epitope	epitope	NN
cord-316534-ep7ezoko	492	67	Genetic	genetic	JJ
cord-316534-ep7ezoko	492	68	incorporation	incorporation	NN
cord-316534-ep7ezoko	492	69	of	of	IN
cord-316534-ep7ezoko	492	70	a	a	DT
cord-316534-ep7ezoko	492	71	herpes	herpes	NNP
cord-316534-ep7ezoko	492	72	simplex	simplex	NN
cord-316534-ep7ezoko	492	73	virus	virus	NN
cord-316534-ep7ezoko	492	74	type	type	NN
cord-316534-ep7ezoko	492	75	1	1	CD
cord-316534-ep7ezoko	492	76	thymidine	thymidine	NN
cord-316534-ep7ezoko	492	77	kinase	kinase	NN
cord-316534-ep7ezoko	492	78	and	and	CC
cord-316534-ep7ezoko	492	79	firefly	firefly	NN
cord-316534-ep7ezoko	492	80	luciferase	luciferase	NN
cord-316534-ep7ezoko	492	81	fusion	fusion	NN
cord-316534-ep7ezoko	492	82	into	into	IN
cord-316534-ep7ezoko	492	83	the	the	DT
cord-316534-ep7ezoko	492	84	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	492	85	protein	protein	NN
cord-316534-ep7ezoko	492	86	IX	IX	NNP
cord-316534-ep7ezoko	492	87	for	for	IN
cord-316534-ep7ezoko	492	88	functional	functional	JJ
cord-316534-ep7ezoko	492	89	display	display	NN
cord-316534-ep7ezoko	492	90	on	on	IN
cord-316534-ep7ezoko	492	91	the	the	DT
cord-316534-ep7ezoko	492	92	virion	virion	NN
cord-316534-ep7ezoko	492	93	Derivation	derivation	NN
cord-316534-ep7ezoko	492	94	of	of	IN
cord-316534-ep7ezoko	492	95	a	a	DT
cord-316534-ep7ezoko	492	96	triple	triple	JJ
cord-316534-ep7ezoko	492	97	mosaic	mosaic	JJ
cord-316534-ep7ezoko	492	98	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	492	99	based	base	VBN
cord-316534-ep7ezoko	492	100	on	on	IN
cord-316534-ep7ezoko	492	101	modification	modification	NN
cord-316534-ep7ezoko	492	102	of	of	IN
cord-316534-ep7ezoko	492	103	the	the	DT
cord-316534-ep7ezoko	492	104	minor	minor	JJ
cord-316534-ep7ezoko	492	105	capsid	capsid	NN
cord-316534-ep7ezoko	492	106	protein	protein	NN
cord-316534-ep7ezoko	492	107	IX	IX	NNP
cord-316534-ep7ezoko	492	108	Genetic	genetic	JJ
cord-316534-ep7ezoko	492	109	incorporation	incorporation	NN
cord-316534-ep7ezoko	492	110	of	of	IN
cord-316534-ep7ezoko	492	111	HSV-1	hsv-1	NN
cord-316534-ep7ezoko	492	112	thymidine	thymidine	IN
cord-316534-ep7ezoko	492	113	kinase	kinase	NN
cord-316534-ep7ezoko	492	114	into	into	IN
cord-316534-ep7ezoko	492	115	the	the	DT
cord-316534-ep7ezoko	492	116	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	492	117	protein	protein	NN
cord-316534-ep7ezoko	492	118	IX	IX	NNP
cord-316534-ep7ezoko	492	119	for	for	IN
cord-316534-ep7ezoko	492	120	functional	functional	JJ
cord-316534-ep7ezoko	492	121	display	display	NN
cord-316534-ep7ezoko	492	122	on	on	IN
cord-316534-ep7ezoko	492	123	the	the	DT
cord-316534-ep7ezoko	492	124	virion	virion	NN
cord-316534-ep7ezoko	492	125	HIV	HIV	NNP
cord-316534-ep7ezoko	492	126	antigen	antigen	NN
cord-316534-ep7ezoko	492	127	incorporation	incorporation	NN
cord-316534-ep7ezoko	492	128	within	within	IN
cord-316534-ep7ezoko	492	129	adenovirus	adenovirus	NN
cord-316534-ep7ezoko	492	130	hexon	hexon	NNP
cord-316534-ep7ezoko	492	131	hypervariable	hypervariable	NNP
cord-316534-ep7ezoko	492	132	2	2	CD
cord-316534-ep7ezoko	492	133	for	for	IN
cord-316534-ep7ezoko	492	134	a	a	DT
cord-316534-ep7ezoko	492	135	novel	novel	JJ
cord-316534-ep7ezoko	492	136	HIV	HIV	NNP
cord-316534-ep7ezoko	492	137	vaccine	vaccine	NN
cord-316534-ep7ezoko	492	138	approach	approach	NN
cord-316534-ep7ezoko	492	139	Use	Use	NNP
cord-316534-ep7ezoko	492	140	of	of	IN
cord-316534-ep7ezoko	492	141	random	random	JJ
cord-316534-ep7ezoko	492	142	systematic	systematic	JJ
cord-316534-ep7ezoko	492	143	mutagenesis	mutagenesis	NN
cord-316534-ep7ezoko	492	144	to	to	TO
cord-316534-ep7ezoko	492	145	generate	generate	VB
cord-316534-ep7ezoko	492	146	viable	viable	JJ
cord-316534-ep7ezoko	492	147	human	human	JJ
cord-316534-ep7ezoko	492	148	rhinovirus	rhinovirus	NN
cord-316534-ep7ezoko	492	149	14	14	CD
cord-316534-ep7ezoko	492	150	chimeras	chimera	NNS
cord-316534-ep7ezoko	492	151	displaying	display	VBG
cord-316534-ep7ezoko	492	152	human	human	JJ
cord-316534-ep7ezoko	492	153	immunodeficiency	immunodeficiency	NN
cord-316534-ep7ezoko	492	154	virus	virus	NN
cord-316534-ep7ezoko	492	155	type	type	NN
cord-316534-ep7ezoko	492	156	1	1	CD
cord-316534-ep7ezoko	492	157	V3	v3	NN
cord-316534-ep7ezoko	492	158	loop	loop	NN
cord-316534-ep7ezoko	492	159	sequences	sequence	NNS
cord-316534-ep7ezoko	492	160	Drug	Drug	NNP
cord-316534-ep7ezoko	492	161	Design	Design	NNP
cord-316534-ep7ezoko	492	162	,	,	,
cord-316534-ep7ezoko	492	163	Development	Development	NNP
cord-316534-ep7ezoko	492	164	and	and	CC
cord-316534-ep7ezoko	492	165	Therapy	Therapy	NNP
cord-316534-ep7ezoko	492	166	The	the	DT
cord-316534-ep7ezoko	492	167	Asian	Asian	NNP
cord-316534-ep7ezoko	492	168	Epidemic	Epidemic	NNP
cord-316534-ep7ezoko	492	169	Model	Model	NNP
cord-316534-ep7ezoko	492	170	:	:	:
cord-316534-ep7ezoko	492	171	a	a	DT
cord-316534-ep7ezoko	492	172	process	process	NN
cord-316534-ep7ezoko	492	173	model	model	NN
cord-316534-ep7ezoko	492	174	for	for	IN
cord-316534-ep7ezoko	492	175	exploring	explore	VBG
cord-316534-ep7ezoko	492	176	HIV	HIV	NNP
cord-316534-ep7ezoko	492	177	policy	policy	NN
cord-316534-ep7ezoko	492	178	and	and	CC
cord-316534-ep7ezoko	492	179	programme	programme	NN
cord-316534-ep7ezoko	492	180	alternatives	alternative	NNS
cord-316534-ep7ezoko	492	181	in	in	IN
cord-316534-ep7ezoko	492	182	Asia	Asia	NNP
cord-316534-ep7ezoko	492	183	HIV	HIV	NNP
cord-316534-ep7ezoko	492	184	/	/	SYM
cord-316534-ep7ezoko	492	185	AIDS	AIDS	NNP
cord-316534-ep7ezoko	492	186	prevention	prevention	NN
cord-316534-ep7ezoko	492	187	in	in	IN
cord-316534-ep7ezoko	492	188	Thailand	Thailand	NNP
cord-316534-ep7ezoko	492	189	:	:	:
cord-316534-ep7ezoko	492	190	success	success	NN
cord-316534-ep7ezoko	492	191	and	and	CC
cord-316534-ep7ezoko	492	192	challenges	challenge	VBZ
cord-316534-ep7ezoko	492	193	The	the	DT
cord-316534-ep7ezoko	492	194	epidemiology	epidemiology	NN
cord-316534-ep7ezoko	492	195	of	of	IN
cord-316534-ep7ezoko	492	196	HIV	HIV	NNP
cord-316534-ep7ezoko	492	197	infection	infection	NN
cord-316534-ep7ezoko	492	198	and	and	CC
cord-316534-ep7ezoko	492	199	AIDS	AIDS	NNP
cord-316534-ep7ezoko	492	200	in	in	IN
cord-316534-ep7ezoko	492	201	Thailand	Thailand	NNP
cord-316534-ep7ezoko	492	202	Preventive	Preventive	NNP
cord-316534-ep7ezoko	492	203	HIV	HIV	NNP
cord-316534-ep7ezoko	492	204	vaccine	vaccine	NN
cord-316534-ep7ezoko	492	205	development	development	NN
cord-316534-ep7ezoko	492	206	in	in	IN
cord-316534-ep7ezoko	492	207	Thailand	Thailand	NNP
cord-316534-ep7ezoko	492	208	Impact	Impact	NNP
cord-316534-ep7ezoko	492	209	of	of	IN
cord-316534-ep7ezoko	492	210	Thailand	Thailand	NNP
cord-316534-ep7ezoko	492	211	's	's	POS
cord-316534-ep7ezoko	492	212	HIV	HIV	NNP
cord-316534-ep7ezoko	492	213	-	-	HYPH
cord-316534-ep7ezoko	492	214	control	control	NN
cord-316534-ep7ezoko	492	215	programme	programme	NN
cord-316534-ep7ezoko	492	216	as	as	IN
cord-316534-ep7ezoko	492	217	indicated	indicate	VBN
cord-316534-ep7ezoko	492	218	by	by	IN
cord-316534-ep7ezoko	492	219	the	the	DT
cord-316534-ep7ezoko	492	220	decline	decline	NN
cord-316534-ep7ezoko	492	221	of	of	IN
cord-316534-ep7ezoko	492	222	sexually	sexually	RB
cord-316534-ep7ezoko	492	223	transmitted	transmit	VBN
cord-316534-ep7ezoko	492	224	diseases	disease	NNS
cord-316534-ep7ezoko	492	225	Risk	risk	NN
cord-316534-ep7ezoko	492	226	factors	factor	NNS
cord-316534-ep7ezoko	492	227	for	for	IN
cord-316534-ep7ezoko	492	228	HIV	HIV	NNP
cord-316534-ep7ezoko	492	229	infection	infection	NN
cord-316534-ep7ezoko	492	230	among	among	IN
cord-316534-ep7ezoko	492	231	young	young	JJ
cord-316534-ep7ezoko	492	232	adult	adult	NN
cord-316534-ep7ezoko	492	233	men	man	NNS
cord-316534-ep7ezoko	492	234	in	in	IN
cord-316534-ep7ezoko	492	235	northern	northern	JJ
cord-316534-ep7ezoko	492	236	Thailand	Thailand	NNP
cord-316534-ep7ezoko	492	237	HIV	HIV	NNP
cord-316534-ep7ezoko	492	238	/	/	SYM
cord-316534-ep7ezoko	492	239	AIDS	AIDS	NNP
cord-316534-ep7ezoko	492	240	preventive	preventive	JJ
cord-316534-ep7ezoko	492	241	vaccine	vaccine	NN
cord-316534-ep7ezoko	492	242	'	'	``
cord-316534-ep7ezoko	492	243	prime	prime	JJ
cord-316534-ep7ezoko	492	244	-	-	HYPH
cord-316534-ep7ezoko	492	245	boost	boost	NN
cord-316534-ep7ezoko	492	246	'	'	''
cord-316534-ep7ezoko	492	247	phase	phase	NN
cord-316534-ep7ezoko	492	248	III	iii	CD
cord-316534-ep7ezoko	492	249	trial	trial	NN
cord-316534-ep7ezoko	492	250	:	:	:
cord-316534-ep7ezoko	492	251	foundations	foundation	NNS
cord-316534-ep7ezoko	492	252	and	and	CC
cord-316534-ep7ezoko	492	253	initial	initial	JJ
cord-316534-ep7ezoko	492	254	lessons	lesson	NNS
cord-316534-ep7ezoko	492	255	learned	learn	VBN
cord-316534-ep7ezoko	492	256	from	from	IN
cord-316534-ep7ezoko	492	257	Thailand	Thailand	NNP
cord-316534-ep7ezoko	492	258	Grant	Grant	NNP
cord-316534-ep7ezoko	492	259	support	support	NN
cord-316534-ep7ezoko	492	260	was	be	VBD
cord-316534-ep7ezoko	492	261	provided	provide	VBN
cord-316534-ep7ezoko	492	262	by	by	IN
cord-316534-ep7ezoko	492	263	National	National	NNP
cord-316534-ep7ezoko	492	264	Institutes	Institutes	NNPS
cord-316534-ep7ezoko	492	265	of	of	IN
cord-316534-ep7ezoko	492	266	Health	Health	NNP
cord-316534-ep7ezoko	492	267	grants	grant	VBZ
cord-316534-ep7ezoko	492	268	1R33AI076096	1R33AI076096	NNP
cord-316534-ep7ezoko	492	269	-	-	HYPH
cord-316534-ep7ezoko	492	270	01	01	CD
cord-316534-ep7ezoko	493	1	,	,	,
cord-316534-ep7ezoko	493	2	2P30AI027767	2P30AI027767	NNP
cord-316534-ep7ezoko	493	3	-	-	HYPH
cord-316534-ep7ezoko	493	4	21A1	21a1	CD
cord-316534-ep7ezoko	493	5	,	,	,
cord-316534-ep7ezoko	493	6	and	and	CC
cord-316534-ep7ezoko	493	7	3P30CA013148	3p30ca013148	CD
cord-316534-ep7ezoko	493	8	-	-	HYPH
cord-316534-ep7ezoko	493	9	38S9	38s9	CD
cord-316534-ep7ezoko	493	10	.	.	.
cord-316534-ep7ezoko	494	1	We	-PRON-	PRP
cord-316534-ep7ezoko	494	2	thank	thank	VBP
cord-316534-ep7ezoko	494	3	Erin	Erin	NNP
cord-316534-ep7ezoko	494	4	E	E	NNP
cord-316534-ep7ezoko	494	5	Thacker	Thacker	NNP
cord-316534-ep7ezoko	494	6	for	for	IN
cord-316534-ep7ezoko	494	7	her	-PRON-	PRP$
cord-316534-ep7ezoko	494	8	thoughtful	thoughtful	JJ
cord-316534-ep7ezoko	494	9	insight	insight	NN
cord-316534-ep7ezoko	494	10	.	.	.
cord-316534-ep7ezoko	495	1	The	the	DT
cord-316534-ep7ezoko	495	2	authors	author	NNS
cord-316534-ep7ezoko	495	3	report	report	VBP
cord-316534-ep7ezoko	495	4	no	no	DT
cord-316534-ep7ezoko	495	5	conflicts	conflict	NNS
cord-316534-ep7ezoko	495	6	of	of	IN
cord-316534-ep7ezoko	495	7	interest	interest	NN
cord-316534-ep7ezoko	495	8	in	in	IN
cord-316534-ep7ezoko	495	9	this	this	DT
cord-316534-ep7ezoko	495	10	work	work	NN
cord-316534-ep7ezoko	495	11	.	.	.
cord-316534-ep7ezoko	496	1	Submit	submit	VB
cord-316534-ep7ezoko	496	2	your	-PRON-	PRP$
cord-316534-ep7ezoko	496	3	manuscript	manuscript	NN
cord-316534-ep7ezoko	496	4	here	here	RB
cord-316534-ep7ezoko	496	5	:	:	:
cord-316534-ep7ezoko	496	6	http://www.dovepress.com/drug-design-development-and-therapy-journal	http://www.dovepress.com/drug-design-development-and-therapy-journal	NNP
cord-316534-ep7ezoko	496	7	Drug	Drug	NNP
cord-316534-ep7ezoko	496	8	Design	Design	NNP
cord-316534-ep7ezoko	496	9	,	,	,
cord-316534-ep7ezoko	496	10	Development	Development	NNP
cord-316534-ep7ezoko	496	11	and	and	CC
cord-316534-ep7ezoko	496	12	Therapy	Therapy	NNP
cord-316534-ep7ezoko	496	13	is	be	VBZ
cord-316534-ep7ezoko	496	14	an	an	DT
cord-316534-ep7ezoko	496	15	international	international	JJ
cord-316534-ep7ezoko	496	16	,	,	,
cord-316534-ep7ezoko	496	17	peerreviewed	peerreviewed	JJ
cord-316534-ep7ezoko	496	18	open	open	JJ
cord-316534-ep7ezoko	496	19	-	-	HYPH
cord-316534-ep7ezoko	496	20	access	access	NN
cord-316534-ep7ezoko	496	21	journal	journal	NN
cord-316534-ep7ezoko	496	22	that	that	WDT
cord-316534-ep7ezoko	496	23	spans	span	VBZ
cord-316534-ep7ezoko	496	24	the	the	DT
cord-316534-ep7ezoko	496	25	spectrum	spectrum	NN
cord-316534-ep7ezoko	496	26	of	of	IN
cord-316534-ep7ezoko	496	27	drug	drug	NN
cord-316534-ep7ezoko	496	28	design	design	NN
cord-316534-ep7ezoko	496	29	and	and	CC
cord-316534-ep7ezoko	496	30	development	development	NN
cord-316534-ep7ezoko	496	31	through	through	IN
cord-316534-ep7ezoko	496	32	to	to	IN
cord-316534-ep7ezoko	496	33	clinical	clinical	JJ
cord-316534-ep7ezoko	496	34	applications	application	NNS
cord-316534-ep7ezoko	496	35	.	.	.
cord-316534-ep7ezoko	497	1	Clinical	clinical	JJ
cord-316534-ep7ezoko	497	2	outcomes	outcome	NNS
cord-316534-ep7ezoko	497	3	,	,	,
cord-316534-ep7ezoko	497	4	patient	patient	JJ
cord-316534-ep7ezoko	497	5	safety	safety	NN
cord-316534-ep7ezoko	497	6	,	,	,
cord-316534-ep7ezoko	497	7	and	and	CC
cord-316534-ep7ezoko	497	8	programs	program	NNS
cord-316534-ep7ezoko	497	9	for	for	IN
cord-316534-ep7ezoko	497	10	the	the	DT
cord-316534-ep7ezoko	497	11	development	development	NN
cord-316534-ep7ezoko	497	12	and	and	CC
cord-316534-ep7ezoko	497	13	effective	effective	JJ
cord-316534-ep7ezoko	497	14	,	,	,
cord-316534-ep7ezoko	497	15	safe	safe	JJ
cord-316534-ep7ezoko	497	16	,	,	,
cord-316534-ep7ezoko	497	17	and	and	CC
cord-316534-ep7ezoko	497	18	sustained	sustain	VBN
cord-316534-ep7ezoko	497	19	use	use	NN
cord-316534-ep7ezoko	497	20	of	of	IN
cord-316534-ep7ezoko	497	21	medicines	medicine	NNS
cord-316534-ep7ezoko	497	22	are	be	VBP
cord-316534-ep7ezoko	497	23	a	a	DT
cord-316534-ep7ezoko	497	24	feature	feature	NN
cord-316534-ep7ezoko	497	25	of	of	IN
cord-316534-ep7ezoko	497	26	the	the	DT
cord-316534-ep7ezoko	497	27	journal	journal	NN
cord-316534-ep7ezoko	497	28	,	,	,
cord-316534-ep7ezoko	497	29	which	which	WDT
cord-316534-ep7ezoko	497	30	has	have	VBZ
cord-316534-ep7ezoko	497	31	also	also	RB
cord-316534-ep7ezoko	497	32	been	be	VBN
cord-316534-ep7ezoko	497	33	accepted	accept	VBN
cord-316534-ep7ezoko	497	34	for	for	IN
cord-316534-ep7ezoko	497	35	indexing	indexing	NN
cord-316534-ep7ezoko	497	36	on	on	IN
cord-316534-ep7ezoko	497	37	PubMed	PubMed	NNP
cord-316534-ep7ezoko	497	38	Central	Central	NNP
cord-316534-ep7ezoko	497	39	.	.	.
cord-316534-ep7ezoko	498	1	The	the	DT
cord-316534-ep7ezoko	498	2	manuscript	manuscript	NN
cord-316534-ep7ezoko	498	3	management	management	NN
cord-316534-ep7ezoko	498	4	system	system	NN
cord-316534-ep7ezoko	498	5	is	be	VBZ
cord-316534-ep7ezoko	498	6	completely	completely	RB
cord-316534-ep7ezoko	498	7	online	online	JJ
cord-316534-ep7ezoko	498	8	and	and	CC
cord-316534-ep7ezoko	498	9	includes	include	VBZ
cord-316534-ep7ezoko	498	10	a	a	DT
cord-316534-ep7ezoko	498	11	very	very	RB
cord-316534-ep7ezoko	498	12	quick	quick	JJ
cord-316534-ep7ezoko	498	13	and	and	CC
cord-316534-ep7ezoko	498	14	fair	fair	JJ
cord-316534-ep7ezoko	498	15	peer	peer	NN
cord-316534-ep7ezoko	498	16	-	-	HYPH
cord-316534-ep7ezoko	498	17	review	review	NN
cord-316534-ep7ezoko	498	18	system	system	NN
cord-316534-ep7ezoko	498	19	,	,	,
cord-316534-ep7ezoko	498	20	which	which	WDT
cord-316534-ep7ezoko	498	21	is	be	VBZ
cord-316534-ep7ezoko	498	22	all	all	RB
cord-316534-ep7ezoko	498	23	easy	easy	JJ
cord-316534-ep7ezoko	498	24	to	to	TO
cord-316534-ep7ezoko	498	25	use	use	VB
cord-316534-ep7ezoko	498	26	.	.	.
cord-316534-ep7ezoko	499	1	Visit	visit	VB
cord-316534-ep7ezoko	499	2	http://www.dovepress.com/testimonials.php	http://www.dovepress.com/testimonials.php	NNP
cord-316534-ep7ezoko	499	3	to	to	TO
cord-316534-ep7ezoko	499	4	read	read	VB
cord-316534-ep7ezoko	499	5	real	real	JJ
cord-316534-ep7ezoko	499	6	quotes	quote	NNS
cord-316534-ep7ezoko	499	7	from	from	IN
cord-316534-ep7ezoko	499	8	published	publish	VBN
cord-316534-ep7ezoko	499	9	authors	author	NNS
cord-316534-ep7ezoko	499	10	.	.	.