id sid tid token lemma pos cord-302530-pp6bl941 1 1 key key NN cord-302530-pp6bl941 1 2 : : : cord-302530-pp6bl941 1 3 cord-302530-pp6bl941 cord-302530-pp6bl941 NNP cord-302530-pp6bl941 1 4 authors author NNS cord-302530-pp6bl941 1 5 : : : cord-302530-pp6bl941 1 6 Gale Gale NNP cord-302530-pp6bl941 1 7 , , , cord-302530-pp6bl941 1 8 Paul Paul NNP cord-302530-pp6bl941 1 9 title title NN cord-302530-pp6bl941 1 10 : : : cord-302530-pp6bl941 2 1 How how WRB cord-302530-pp6bl941 2 2 virus virus NN cord-302530-pp6bl941 2 3 size size NN cord-302530-pp6bl941 2 4 and and CC cord-302530-pp6bl941 2 5 attachment attachment NN cord-302530-pp6bl941 2 6 parameters parameter NNS cord-302530-pp6bl941 2 7 affect affect VBP cord-302530-pp6bl941 2 8 the the DT cord-302530-pp6bl941 2 9 temperature temperature NN cord-302530-pp6bl941 2 10 sensitivity sensitivity NN cord-302530-pp6bl941 2 11 of of IN cord-302530-pp6bl941 2 12 virus virus NN cord-302530-pp6bl941 2 13 binding bind VBG cord-302530-pp6bl941 2 14 to to IN cord-302530-pp6bl941 2 15 host host NN cord-302530-pp6bl941 2 16 cells cell NNS cord-302530-pp6bl941 2 17 : : : cord-302530-pp6bl941 3 1 Predictions prediction NNS cord-302530-pp6bl941 3 2 of of IN cord-302530-pp6bl941 3 3 a a DT cord-302530-pp6bl941 3 4 thermodynamic thermodynamic JJ cord-302530-pp6bl941 3 5 model model NN cord-302530-pp6bl941 3 6 for for IN cord-302530-pp6bl941 3 7 arboviruses arboviruses NNP cord-302530-pp6bl941 3 8 and and CC cord-302530-pp6bl941 3 9 HIV HIV NNP cord-302530-pp6bl941 3 10 date date NN cord-302530-pp6bl941 3 11 : : : cord-302530-pp6bl941 3 12 2020 2020 CD cord-302530-pp6bl941 3 13 - - HYPH cord-302530-pp6bl941 3 14 03 03 CD cord-302530-pp6bl941 3 15 - - HYPH cord-302530-pp6bl941 3 16 12 12 CD cord-302530-pp6bl941 3 17 journal journal NN cord-302530-pp6bl941 3 18 : : : cord-302530-pp6bl941 4 1 Microb Microb NNP cord-302530-pp6bl941 4 2 Risk Risk NNP cord-302530-pp6bl941 4 3 Anal anal JJ cord-302530-pp6bl941 4 4 DOI doi NN cord-302530-pp6bl941 4 5 : : : cord-302530-pp6bl941 5 1 10.1016/ 10.1016/ CD cord-302530-pp6bl941 6 1 j.mran.2020.100104 j.mran.2020.100104 NNP cord-302530-pp6bl941 7 1 sha sha NNP cord-302530-pp6bl941 7 2 : : : cord-302530-pp6bl941 8 1 bf0a09d3c2554ec1d4765750011c6668ad394ab2 bf0a09d3c2554ec1d4765750011c6668ad394ab2 NNP cord-302530-pp6bl941 8 2 doc_id doc_id CD cord-302530-pp6bl941 8 3 : : : cord-302530-pp6bl941 8 4 302530 302530 CD cord-302530-pp6bl941 8 5 cord_uid cord_uid NNS cord-302530-pp6bl941 8 6 : : : cord-302530-pp6bl941 9 1 pp6bl941 pp6bl941 NNP cord-302530-pp6bl941 9 2 Virus virus NN cord-302530-pp6bl941 9 3 binding bind VBG cord-302530-pp6bl941 9 4 to to IN cord-302530-pp6bl941 9 5 host host NN cord-302530-pp6bl941 9 6 cells cell NNS cord-302530-pp6bl941 9 7 involves involve VBZ cord-302530-pp6bl941 9 8 specific specific JJ cord-302530-pp6bl941 9 9 interactions interaction NNS cord-302530-pp6bl941 9 10 between between IN cord-302530-pp6bl941 9 11 viral viral JJ cord-302530-pp6bl941 9 12 ( ( -LRB- cord-302530-pp6bl941 9 13 glyco)proteins glyco)protein NNS cord-302530-pp6bl941 9 14 ( ( -LRB- cord-302530-pp6bl941 9 15 GP GP NNP cord-302530-pp6bl941 9 16 ) ) -RRB- cord-302530-pp6bl941 9 17 and and CC cord-302530-pp6bl941 9 18 host host NN cord-302530-pp6bl941 9 19 cell cell NN cord-302530-pp6bl941 9 20 surface surface NN cord-302530-pp6bl941 9 21 receptors receptor NNS cord-302530-pp6bl941 9 22 ( ( -LRB- cord-302530-pp6bl941 9 23 Cr cr NN cord-302530-pp6bl941 9 24 ) ) -RRB- cord-302530-pp6bl941 9 25 ( ( -LRB- cord-302530-pp6bl941 10 1 protein protein NN cord-302530-pp6bl941 10 2 or or CC cord-302530-pp6bl941 10 3 sialic sialic JJ cord-302530-pp6bl941 10 4 acid acid NN cord-302530-pp6bl941 10 5 ( ( -LRB- cord-302530-pp6bl941 10 6 SA SA NNP cord-302530-pp6bl941 10 7 ) ) -RRB- cord-302530-pp6bl941 10 8 ) ) -RRB- cord-302530-pp6bl941 10 9 . . . cord-302530-pp6bl941 11 1 The the DT cord-302530-pp6bl941 11 2 magnitude magnitude NN cord-302530-pp6bl941 11 3 of of IN cord-302530-pp6bl941 11 4 the the DT cord-302530-pp6bl941 11 5 enthalpy enthalpy NN cord-302530-pp6bl941 11 6 of of IN cord-302530-pp6bl941 11 7 association association NN cord-302530-pp6bl941 11 8 changes change NNS cord-302530-pp6bl941 11 9 with with IN cord-302530-pp6bl941 11 10 temperature temperature NN cord-302530-pp6bl941 11 11 according accord VBG cord-302530-pp6bl941 11 12 to to IN cord-302530-pp6bl941 11 13 the the DT cord-302530-pp6bl941 11 14 change change NN cord-302530-pp6bl941 11 15 in in IN cord-302530-pp6bl941 11 16 heat heat NN cord-302530-pp6bl941 11 17 capacity capacity NN cord-302530-pp6bl941 11 18 ( ( -LRB- cord-302530-pp6bl941 11 19 ΔC(p ΔC(p NNP cord-302530-pp6bl941 11 20 ) ) -RRB- cord-302530-pp6bl941 11 21 ) ) -RRB- cord-302530-pp6bl941 11 22 on on IN cord-302530-pp6bl941 11 23 GP GP NNP cord-302530-pp6bl941 11 24 / / SYM cord-302530-pp6bl941 11 25 Cr cr NN cord-302530-pp6bl941 11 26 binding binding NN cord-302530-pp6bl941 11 27 , , , cord-302530-pp6bl941 11 28 being be VBG cord-302530-pp6bl941 11 29 little little RB cord-302530-pp6bl941 11 30 affected affect VBN cord-302530-pp6bl941 11 31 for for IN cord-302530-pp6bl941 12 1 avian avian JJ cord-302530-pp6bl941 12 2 influenza influenza NN cord-302530-pp6bl941 12 3 virus virus NN cord-302530-pp6bl941 12 4 ( ( -LRB- cord-302530-pp6bl941 12 5 AIV AIV NNP cord-302530-pp6bl941 12 6 ) ) -RRB- cord-302530-pp6bl941 12 7 haemagglutinin haemagglutinin NNP cord-302530-pp6bl941 12 8 ( ( -LRB- cord-302530-pp6bl941 12 9 HA HA NNP cord-302530-pp6bl941 12 10 ) ) -RRB- cord-302530-pp6bl941 12 11 binding bind VBG cord-302530-pp6bl941 12 12 to to IN cord-302530-pp6bl941 12 13 SA SA NNP cord-302530-pp6bl941 12 14 ( ( -LRB- cord-302530-pp6bl941 12 15 ΔC(p ΔC(p NNP cord-302530-pp6bl941 12 16 ) ) -RRB- cord-302530-pp6bl941 12 17 = = SYM cord-302530-pp6bl941 12 18 0 0 NFP cord-302530-pp6bl941 13 1 kJ kJ NNP cord-302530-pp6bl941 13 2 / / SYM cord-302530-pp6bl941 13 3 mol mol NNP cord-302530-pp6bl941 13 4 / / SYM cord-302530-pp6bl941 13 5 K K NNP cord-302530-pp6bl941 13 6 ) ) -RRB- cord-302530-pp6bl941 13 7 but but CC cord-302530-pp6bl941 13 8 greatly greatly RB cord-302530-pp6bl941 13 9 affected affected JJ cord-302530-pp6bl941 13 10 for for IN cord-302530-pp6bl941 13 11 HIV HIV NNP cord-302530-pp6bl941 14 1 gp120 gp120 NNP cord-302530-pp6bl941 14 2 binding bind VBG cord-302530-pp6bl941 14 3 to to IN cord-302530-pp6bl941 14 4 CD4 CD4 NNP cord-302530-pp6bl941 14 5 receptor receptor NN cord-302530-pp6bl941 14 6 ( ( -LRB- cord-302530-pp6bl941 14 7 ΔC(p ΔC(p NNP cord-302530-pp6bl941 14 8 ) ) -RRB- cord-302530-pp6bl941 14 9 = = NFP cord-302530-pp6bl941 15 1 −5.0 −5.0 NN cord-302530-pp6bl941 16 1 kJ kJ NNP cord-302530-pp6bl941 16 2 / / SYM cord-302530-pp6bl941 16 3 mol mol NNP cord-302530-pp6bl941 16 4 / / SYM cord-302530-pp6bl941 16 5 K K NNP cord-302530-pp6bl941 16 6 ) ) -RRB- cord-302530-pp6bl941 16 7 . . . cord-302530-pp6bl941 17 1 A a DT cord-302530-pp6bl941 17 2 thermodynamic thermodynamic JJ cord-302530-pp6bl941 17 3 model model NN cord-302530-pp6bl941 17 4 developed develop VBN cord-302530-pp6bl941 17 5 here here RB cord-302530-pp6bl941 17 6 predicts predict VBZ cord-302530-pp6bl941 17 7 that that IN cord-302530-pp6bl941 17 8 values value NNS cord-302530-pp6bl941 17 9 of of IN cord-302530-pp6bl941 17 10 ΔC(p ΔC(p NNS cord-302530-pp6bl941 17 11 ) ) -RRB- cord-302530-pp6bl941 17 12 from from IN cord-302530-pp6bl941 17 13 0 0 CD cord-302530-pp6bl941 17 14 to to IN cord-302530-pp6bl941 17 15 ~−2.0 ~−2.0 . cord-302530-pp6bl941 18 1 kJ kJ NNP cord-302530-pp6bl941 18 2 / / SYM cord-302530-pp6bl941 18 3 mol mol NNP cord-302530-pp6bl941 18 4 / / SYM cord-302530-pp6bl941 18 5 K K NNP cord-302530-pp6bl941 18 6 have have VBP cord-302530-pp6bl941 18 7 relatively relatively RB cord-302530-pp6bl941 18 8 little little JJ cord-302530-pp6bl941 18 9 impact impact NN cord-302530-pp6bl941 18 10 on on IN cord-302530-pp6bl941 18 11 the the DT cord-302530-pp6bl941 18 12 temperature temperature NN cord-302530-pp6bl941 18 13 sensitivity sensitivity NN cord-302530-pp6bl941 18 14 of of IN cord-302530-pp6bl941 18 15 the the DT cord-302530-pp6bl941 18 16 number number NN cord-302530-pp6bl941 18 17 of of IN cord-302530-pp6bl941 18 18 mosquito mosquito NN cord-302530-pp6bl941 18 19 midgut midgut NN cord-302530-pp6bl941 18 20 cells cell NNS cord-302530-pp6bl941 18 21 with with IN cord-302530-pp6bl941 18 22 bound bound NNP cord-302530-pp6bl941 18 23 arbovirus arbovirus NN cord-302530-pp6bl941 18 24 , , , cord-302530-pp6bl941 18 25 while while IN cord-302530-pp6bl941 18 26 intermediate intermediate JJ cord-302530-pp6bl941 18 27 values value NNS cord-302530-pp6bl941 18 28 of of IN cord-302530-pp6bl941 18 29 ΔC(p ΔC(p NNS cord-302530-pp6bl941 18 30 ) ) -RRB- cord-302530-pp6bl941 18 31 of of IN cord-302530-pp6bl941 18 32 ~−3.0 ~−3.0 NNP cord-302530-pp6bl941 19 1 kJ kJ NNP cord-302530-pp6bl941 19 2 / / SYM cord-302530-pp6bl941 19 3 mol mol NNP cord-302530-pp6bl941 19 4 / / SYM cord-302530-pp6bl941 19 5 K K NNP cord-302530-pp6bl941 19 6 give give VBP cord-302530-pp6bl941 19 7 a a DT cord-302530-pp6bl941 19 8 peak peak NN cord-302530-pp6bl941 19 9 binding binding NN cord-302530-pp6bl941 19 10 at at IN cord-302530-pp6bl941 19 11 a a DT cord-302530-pp6bl941 19 12 temperature temperature NN cord-302530-pp6bl941 19 13 of of IN cord-302530-pp6bl941 19 14 ~20 ~20 NFP cord-302530-pp6bl941 19 15 ° ° NN cord-302530-pp6bl941 19 16 C C NNP cord-302530-pp6bl941 19 17 as as IN cord-302530-pp6bl941 19 18 observed observe VBN cord-302530-pp6bl941 19 19 experimentally experimentally RB cord-302530-pp6bl941 19 20 for for IN cord-302530-pp6bl941 19 21 Western western JJ cord-302530-pp6bl941 19 22 equine equine JJ cord-302530-pp6bl941 19 23 encephalitis encephalitis NN cord-302530-pp6bl941 19 24 virus virus NN cord-302530-pp6bl941 19 25 . . . cord-302530-pp6bl941 20 1 More more RBR cord-302530-pp6bl941 20 2 negative negative JJ cord-302530-pp6bl941 20 3 values value NNS cord-302530-pp6bl941 20 4 of of IN cord-302530-pp6bl941 20 5 ΔC(p ΔC(p NNS cord-302530-pp6bl941 20 6 ) ) -RRB- cord-302530-pp6bl941 20 7 greatly greatly RB cord-302530-pp6bl941 20 8 decrease decrease VB cord-302530-pp6bl941 20 9 arbovirus arbovirus NN cord-302530-pp6bl941 20 10 binding bind VBG cord-302530-pp6bl941 20 11 at at IN cord-302530-pp6bl941 20 12 temperatures temperature NNS cord-302530-pp6bl941 20 13 below below IN cord-302530-pp6bl941 20 14 ~20 ~20 NFP cord-302530-pp6bl941 20 15 ° ° NN cord-302530-pp6bl941 20 16 C C NNP cord-302530-pp6bl941 20 17 . . . cord-302530-pp6bl941 21 1 Thus thus RB cord-302530-pp6bl941 21 2 to to TO cord-302530-pp6bl941 21 3 promote promote VB cord-302530-pp6bl941 21 4 transmission transmission NN cord-302530-pp6bl941 21 5 at at IN cord-302530-pp6bl941 21 6 low low JJ cord-302530-pp6bl941 21 7 temperatures temperature NNS cord-302530-pp6bl941 21 8 , , , cord-302530-pp6bl941 21 9 arboviruses arbovirus NNS cord-302530-pp6bl941 21 10 may may MD cord-302530-pp6bl941 21 11 benefit benefit VB cord-302530-pp6bl941 21 12 from from IN cord-302530-pp6bl941 21 13 ΔC(p ΔC(p NNS cord-302530-pp6bl941 21 14 ) ) -RRB- cord-302530-pp6bl941 21 15 ~ ~ NFP cord-302530-pp6bl941 21 16 0 0 NFP cord-302530-pp6bl941 21 17 kJ kJ NNP cord-302530-pp6bl941 21 18 / / SYM cord-302530-pp6bl941 21 19 mol mol NNP cord-302530-pp6bl941 21 20 / / SYM cord-302530-pp6bl941 21 21 K K NNP cord-302530-pp6bl941 21 22 as as IN cord-302530-pp6bl941 21 23 for for IN cord-302530-pp6bl941 21 24 HA HA NNP cord-302530-pp6bl941 21 25 / / SYM cord-302530-pp6bl941 21 26 SA SA NNP cord-302530-pp6bl941 22 1 and and CC cord-302530-pp6bl941 22 2 it -PRON- PRP cord-302530-pp6bl941 22 3 is be VBZ cord-302530-pp6bl941 22 4 interesting interesting JJ cord-302530-pp6bl941 22 5 that that IN cord-302530-pp6bl941 22 6 bluetongue bluetongue NN cord-302530-pp6bl941 22 7 virus virus NN cord-302530-pp6bl941 22 8 binds bind VBZ cord-302530-pp6bl941 22 9 to to IN cord-302530-pp6bl941 22 10 SA SA NNP cord-302530-pp6bl941 22 11 in in IN cord-302530-pp6bl941 22 12 midge midge NNP cord-302530-pp6bl941 22 13 midguts midguts NNP cord-302530-pp6bl941 22 14 . . . cord-302530-pp6bl941 23 1 Large large JJ cord-302530-pp6bl941 23 2 negative negative JJ cord-302530-pp6bl941 23 3 values value NNS cord-302530-pp6bl941 23 4 of of IN cord-302530-pp6bl941 23 5 ΔC(p ΔC(p NNS cord-302530-pp6bl941 23 6 ) ) -RRB- cord-302530-pp6bl941 23 7 as as IN cord-302530-pp6bl941 23 8 for for IN cord-302530-pp6bl941 23 9 HIV HIV NNP cord-302530-pp6bl941 23 10 gp120 gp120 NNP cord-302530-pp6bl941 23 11 : : : cord-302530-pp6bl941 24 1 CD4 CD4 NNP cord-302530-pp6bl941 24 2 diminish diminish VBP cord-302530-pp6bl941 24 3 binding bind VBG cord-302530-pp6bl941 24 4 at at IN cord-302530-pp6bl941 24 5 37 37 CD cord-302530-pp6bl941 24 6 ° ° NN cord-302530-pp6bl941 24 7 C c NN cord-302530-pp6bl941 24 8 . . . cord-302530-pp6bl941 25 1 Of of IN cord-302530-pp6bl941 25 2 greater great JJR cord-302530-pp6bl941 25 3 importance importance NN cord-302530-pp6bl941 25 4 , , , cord-302530-pp6bl941 25 5 however however RB cord-302530-pp6bl941 25 6 , , , cord-302530-pp6bl941 25 7 is be VBZ cord-302530-pp6bl941 25 8 the the DT cord-302530-pp6bl941 25 9 decrease decrease NN cord-302530-pp6bl941 25 10 in in IN cord-302530-pp6bl941 25 11 entropy entropy NN cord-302530-pp6bl941 25 12 of of IN cord-302530-pp6bl941 25 13 the the DT cord-302530-pp6bl941 25 14 whole whole JJ cord-302530-pp6bl941 25 15 virus virus NN cord-302530-pp6bl941 25 16 ( ( -LRB- cord-302530-pp6bl941 25 17 ΔS(a_immob ΔS(a_immob NNP cord-302530-pp6bl941 25 18 ) ) -RRB- cord-302530-pp6bl941 25 19 ) ) -RRB- cord-302530-pp6bl941 25 20 on on IN cord-302530-pp6bl941 25 21 its -PRON- PRP$ cord-302530-pp6bl941 25 22 immobilisation immobilisation NN cord-302530-pp6bl941 25 23 on on IN cord-302530-pp6bl941 25 24 the the DT cord-302530-pp6bl941 25 25 host host NN cord-302530-pp6bl941 25 26 cell cell NN cord-302530-pp6bl941 25 27 surface surface NN cord-302530-pp6bl941 25 28 . . . cord-302530-pp6bl941 26 1 ΔS(a_immob ΔS(a_immob NNP cord-302530-pp6bl941 26 2 ) ) -RRB- cord-302530-pp6bl941 26 3 presents present VBZ cord-302530-pp6bl941 26 4 a a DT cord-302530-pp6bl941 26 5 repulsive repulsive JJ cord-302530-pp6bl941 26 6 force force NN cord-302530-pp6bl941 26 7 which which WDT cord-302530-pp6bl941 26 8 the the DT cord-302530-pp6bl941 26 9 enthalpy enthalpy NN cord-302530-pp6bl941 26 10 - - HYPH cord-302530-pp6bl941 26 11 driven drive VBN cord-302530-pp6bl941 26 12 GP GP NNP cord-302530-pp6bl941 26 13 / / SYM cord-302530-pp6bl941 26 14 Cr cr NN cord-302530-pp6bl941 26 15 interactions interaction NNS cord-302530-pp6bl941 26 16 weakened weaken VBD cord-302530-pp6bl941 26 17 at at IN cord-302530-pp6bl941 26 18 higher high JJR cord-302530-pp6bl941 26 19 temperatures temperature NNS cord-302530-pp6bl941 26 20 struggle struggle VBP cord-302530-pp6bl941 26 21 to to TO cord-302530-pp6bl941 26 22 overcome overcome VB cord-302530-pp6bl941 26 23 . . . cord-302530-pp6bl941 27 1 ΔS(a_immob ΔS(a_immob NNP cord-302530-pp6bl941 27 2 ) ) -RRB- cord-302530-pp6bl941 27 3 is be VBZ cord-302530-pp6bl941 27 4 more more RBR cord-302530-pp6bl941 27 5 negative negative JJ cord-302530-pp6bl941 27 6 ( ( -LRB- cord-302530-pp6bl941 27 7 less less RBR cord-302530-pp6bl941 27 8 favourable favourable JJ cord-302530-pp6bl941 27 9 ) ) -RRB- cord-302530-pp6bl941 27 10 for for IN cord-302530-pp6bl941 27 11 larger large JJR cord-302530-pp6bl941 27 12 diameter diameter NN cord-302530-pp6bl941 27 13 viruses virus NNS cord-302530-pp6bl941 27 14 which which WDT cord-302530-pp6bl941 27 15 therefore therefore RB cord-302530-pp6bl941 27 16 show show VBP cord-302530-pp6bl941 27 17 diminished diminish VBN cord-302530-pp6bl941 27 18 binding bind VBG cord-302530-pp6bl941 27 19 at at IN cord-302530-pp6bl941 27 20 higher high JJR cord-302530-pp6bl941 27 21 temperatures temperature NNS cord-302530-pp6bl941 27 22 than than IN cord-302530-pp6bl941 27 23 smaller small JJR cord-302530-pp6bl941 27 24 viruses virus NNS cord-302530-pp6bl941 27 25 . . . cord-302530-pp6bl941 28 1 It -PRON- PRP cord-302530-pp6bl941 28 2 is be VBZ cord-302530-pp6bl941 28 3 proposed propose VBN cord-302530-pp6bl941 28 4 that that IN cord-302530-pp6bl941 28 5 small small JJ cord-302530-pp6bl941 28 6 size size NN cord-302530-pp6bl941 28 7 phenotype phenotype NN cord-302530-pp6bl941 28 8 through through IN cord-302530-pp6bl941 28 9 a a DT cord-302530-pp6bl941 28 10 less less RBR cord-302530-pp6bl941 28 11 negative negative JJ cord-302530-pp6bl941 28 12 ΔS(a_immob ΔS(a_immob NNP cord-302530-pp6bl941 28 13 ) ) -RRB- cord-302530-pp6bl941 28 14 is be VBZ cord-302530-pp6bl941 28 15 selected select VBN cord-302530-pp6bl941 28 16 for for IN cord-302530-pp6bl941 28 17 viruses virus NNS cord-302530-pp6bl941 28 18 infecting infect VBG cord-302530-pp6bl941 28 19 warmer warm JJR cord-302530-pp6bl941 28 20 hosts host NNS cord-302530-pp6bl941 28 21 thus thus RB cord-302530-pp6bl941 28 22 explaining explain VBG cord-302530-pp6bl941 28 23 the the DT cord-302530-pp6bl941 28 24 observation observation NN cord-302530-pp6bl941 28 25 that that IN cord-302530-pp6bl941 28 26 virion virion NN cord-302530-pp6bl941 28 27 volume volume NN cord-302530-pp6bl941 28 28 decreases decrease VBZ cord-302530-pp6bl941 28 29 with with IN cord-302530-pp6bl941 28 30 increasing increase VBG cord-302530-pp6bl941 28 31 host host NN cord-302530-pp6bl941 28 32 temperature temperature NN cord-302530-pp6bl941 28 33 from from IN cord-302530-pp6bl941 28 34 0 0 CD cord-302530-pp6bl941 28 35 ° ° NN cord-302530-pp6bl941 28 36 C c NN cord-302530-pp6bl941 28 37 to to IN cord-302530-pp6bl941 28 38 40 40 CD cord-302530-pp6bl941 28 39 ° ° NN cord-302530-pp6bl941 28 40 C c NN cord-302530-pp6bl941 28 41 in in IN cord-302530-pp6bl941 28 42 the the DT cord-302530-pp6bl941 28 43 case case NN cord-302530-pp6bl941 28 44 of of IN cord-302530-pp6bl941 28 45 dsDNA dsdna JJ cord-302530-pp6bl941 28 46 viruses virus NNS cord-302530-pp6bl941 28 47 . . . cord-302530-pp6bl941 29 1 Compared compare VBN cord-302530-pp6bl941 29 2 to to IN cord-302530-pp6bl941 29 3 arboviruses arbovirus NNS cord-302530-pp6bl941 29 4 which which WDT cord-302530-pp6bl941 29 5 also also RB cord-302530-pp6bl941 29 6 infect infect VBP cord-302530-pp6bl941 29 7 warm warm JJ cord-302530-pp6bl941 29 8 - - HYPH cord-302530-pp6bl941 29 9 blooded blooded JJ cord-302530-pp6bl941 29 10 vertebrates vertebrate NNS cord-302530-pp6bl941 29 11 , , , cord-302530-pp6bl941 29 12 HIV HIV NNP cord-302530-pp6bl941 29 13 is be VBZ cord-302530-pp6bl941 29 14 large large JJ cord-302530-pp6bl941 29 15 at at IN cord-302530-pp6bl941 29 16 134 134 CD cord-302530-pp6bl941 29 17 nm nm NN cord-302530-pp6bl941 29 18 diameter diameter NN cord-302530-pp6bl941 29 19 and and CC cord-302530-pp6bl941 29 20 thus thus RB cord-302530-pp6bl941 29 21 would would MD cord-302530-pp6bl941 29 22 have have VB cord-302530-pp6bl941 29 23 a a DT cord-302530-pp6bl941 29 24 large large JJ cord-302530-pp6bl941 29 25 negative negative JJ cord-302530-pp6bl941 29 26 ΔS(a_immob δs(a_immob NN cord-302530-pp6bl941 29 27 ) ) -RRB- cord-302530-pp6bl941 29 28 which which WDT cord-302530-pp6bl941 29 29 would would MD cord-302530-pp6bl941 29 30 diminish diminish VB cord-302530-pp6bl941 29 31 its -PRON- PRP$ cord-302530-pp6bl941 29 32 binding binding NN cord-302530-pp6bl941 29 33 at at IN cord-302530-pp6bl941 29 34 human human JJ cord-302530-pp6bl941 29 35 body body NN cord-302530-pp6bl941 29 36 temperature temperature NN cord-302530-pp6bl941 29 37 . . . cord-302530-pp6bl941 30 1 It -PRON- PRP cord-302530-pp6bl941 30 2 is be VBZ cord-302530-pp6bl941 30 3 proposed propose VBN cord-302530-pp6bl941 30 4 that that IN cord-302530-pp6bl941 30 5 prior prior JJ cord-302530-pp6bl941 30 6 non non JJ cord-302530-pp6bl941 30 7 - - JJ cord-302530-pp6bl941 30 8 specific specific JJ cord-302530-pp6bl941 30 9 binding binding NN cord-302530-pp6bl941 30 10 of of IN cord-302530-pp6bl941 30 11 HIV HIV NNP cord-302530-pp6bl941 30 12 through through IN cord-302530-pp6bl941 30 13 attachment attachment NN cord-302530-pp6bl941 30 14 factors factor NNS cord-302530-pp6bl941 30 15 takes take VBZ cord-302530-pp6bl941 30 16 much much JJ cord-302530-pp6bl941 30 17 of of IN cord-302530-pp6bl941 30 18 the the DT cord-302530-pp6bl941 30 19 entropy entropy NN cord-302530-pp6bl941 30 20 loss loss NN cord-302530-pp6bl941 30 21 for for IN cord-302530-pp6bl941 30 22 ΔS(a_immob ΔS(a_immob NNP cord-302530-pp6bl941 30 23 ) ) -RRB- cord-302530-pp6bl941 31 1 so so RB cord-302530-pp6bl941 31 2 enhancing enhance VBG cord-302530-pp6bl941 31 3 subsequent subsequent JJ cord-302530-pp6bl941 31 4 specific specific JJ cord-302530-pp6bl941 31 5 gp120 gp120 NN cord-302530-pp6bl941 31 6 : : : cord-302530-pp6bl941 32 1 CD4 CD4 NNP cord-302530-pp6bl941 32 2 binding bind VBG cord-302530-pp6bl941 32 3 at at IN cord-302530-pp6bl941 32 4 37 37 CD cord-302530-pp6bl941 32 5 ° ° NN cord-302530-pp6bl941 32 6 C c NN cord-302530-pp6bl941 32 7 . . . cord-302530-pp6bl941 33 1 This this DT cord-302530-pp6bl941 33 2 is be VBZ cord-302530-pp6bl941 33 3 consistent consistent JJ cord-302530-pp6bl941 33 4 with with IN cord-302530-pp6bl941 33 5 the the DT cord-302530-pp6bl941 33 6 observation observation NN cord-302530-pp6bl941 33 7 that that IN cord-302530-pp6bl941 33 8 HIV HIV NNP cord-302530-pp6bl941 33 9 attachment attachment NN cord-302530-pp6bl941 33 10 factors factor NNS cord-302530-pp6bl941 33 11 are be VBP cord-302530-pp6bl941 33 12 not not RB cord-302530-pp6bl941 33 13 essential essential JJ cord-302530-pp6bl941 33 14 but but CC cord-302530-pp6bl941 33 15 augment augment VB cord-302530-pp6bl941 33 16 infection infection NN cord-302530-pp6bl941 33 17 . . . cord-302530-pp6bl941 34 1 Antiviral antiviral JJ cord-302530-pp6bl941 34 2 therapies therapy NNS cord-302530-pp6bl941 34 3 should should MD cord-302530-pp6bl941 34 4 focus focus VB cord-302530-pp6bl941 34 5 on on IN cord-302530-pp6bl941 34 6 increasing increase VBG cord-302530-pp6bl941 34 7 virion virion NN cord-302530-pp6bl941 34 8 size size NN cord-302530-pp6bl941 34 9 , , , cord-302530-pp6bl941 34 10 for for IN cord-302530-pp6bl941 34 11 example example NN cord-302530-pp6bl941 34 12 through through IN cord-302530-pp6bl941 34 13 binding binding NN cord-302530-pp6bl941 34 14 of of IN cord-302530-pp6bl941 34 15 zinc zinc NN cord-302530-pp6bl941 34 16 oxide oxide NN cord-302530-pp6bl941 34 17 nanoparticles nanoparticle NNS cord-302530-pp6bl941 34 18 to to IN cord-302530-pp6bl941 34 19 herpes herpes NN cord-302530-pp6bl941 34 20 simplex simplex NNP cord-302530-pp6bl941 34 21 virus virus NN cord-302530-pp6bl941 34 22 , , , cord-302530-pp6bl941 34 23 hence hence RB cord-302530-pp6bl941 34 24 making make VBG cord-302530-pp6bl941 34 25 ΔS(a_immob ΔS(a_immob NNP cord-302530-pp6bl941 34 26 ) ) -RRB- cord-302530-pp6bl941 34 27 more more RBR cord-302530-pp6bl941 34 28 negative negative JJ cord-302530-pp6bl941 34 29 , , , cord-302530-pp6bl941 34 30 and and CC cord-302530-pp6bl941 34 31 thus thus RB cord-302530-pp6bl941 34 32 reducing reduce VBG cord-302530-pp6bl941 34 33 binding bind VBG cord-302530-pp6bl941 34 34 affinity affinity NN cord-302530-pp6bl941 34 35 at at IN cord-302530-pp6bl941 34 36 37 37 CD cord-302530-pp6bl941 34 37 ° ° NN cord-302530-pp6bl941 34 38 C c NN cord-302530-pp6bl941 34 39 . . . cord-302530-pp6bl941 35 1 Some some DT cord-302530-pp6bl941 35 2 viruses virus NNS cord-302530-pp6bl941 35 3 infect infect VBP cord-302530-pp6bl941 35 4 hosts host NNS cord-302530-pp6bl941 35 5 over over IN cord-302530-pp6bl941 35 6 a a DT cord-302530-pp6bl941 35 7 range range NN cord-302530-pp6bl941 35 8 of of IN cord-302530-pp6bl941 35 9 temperatures temperature NNS cord-302530-pp6bl941 35 10 depending depend VBG cord-302530-pp6bl941 35 11 on on IN cord-302530-pp6bl941 35 12 the the DT cord-302530-pp6bl941 35 13 host host NN cord-302530-pp6bl941 35 14 species specie NNS cord-302530-pp6bl941 35 15 . . . cord-302530-pp6bl941 36 1 Most most RBS cord-302530-pp6bl941 36 2 notable notable JJ cord-302530-pp6bl941 36 3 are be VBP cord-302530-pp6bl941 36 4 the the DT cord-302530-pp6bl941 36 5 arboviruses arbovirus NNS cord-302530-pp6bl941 36 6 which which WDT cord-302530-pp6bl941 36 7 may may MD cord-302530-pp6bl941 36 8 infect infect VB cord-302530-pp6bl941 36 9 the the DT cord-302530-pp6bl941 36 10 arthropod arthropod JJ cord-302530-pp6bl941 36 11 vector vector NN cord-302530-pp6bl941 36 12 over over IN cord-302530-pp6bl941 36 13 a a DT cord-302530-pp6bl941 36 14 range range NN cord-302530-pp6bl941 36 15 of of IN cord-302530-pp6bl941 36 16 ambient ambient JJ cord-302530-pp6bl941 36 17 temperatures temperature NNS cord-302530-pp6bl941 36 18 from~15 from~15 NNP cord-302530-pp6bl941 36 19 ° ° NN cord-302530-pp6bl941 36 20 C c NN cord-302530-pp6bl941 36 21 to to IN cord-302530-pp6bl941 36 22 > > XX cord-302530-pp6bl941 36 23 30 30 CD cord-302530-pp6bl941 36 24 ° ° NN cord-302530-pp6bl941 36 25 C C NNP cord-302530-pp6bl941 36 26 ( ( -LRB- cord-302530-pp6bl941 36 27 Mullens Mullens NNP cord-302530-pp6bl941 36 28 et et NNP cord-302530-pp6bl941 36 29 al al NNP cord-302530-pp6bl941 36 30 . . NNP cord-302530-pp6bl941 36 31 , , , cord-302530-pp6bl941 36 32 2004 2004 CD cord-302530-pp6bl941 36 33 ) ) -RRB- cord-302530-pp6bl941 36 34 , , , cord-302530-pp6bl941 36 35 and and CC cord-302530-pp6bl941 36 36 then then RB cord-302530-pp6bl941 36 37 infect infect VB cord-302530-pp6bl941 36 38 a a DT cord-302530-pp6bl941 36 39 vertebrate vertebrate JJ cord-302530-pp6bl941 36 40 host host NN cord-302530-pp6bl941 36 41 at at IN cord-302530-pp6bl941 36 42 temperatures temperature NNS cord-302530-pp6bl941 36 43 from from IN cord-302530-pp6bl941 36 44 37 37 CD cord-302530-pp6bl941 36 45 ° ° NN cord-302530-pp6bl941 36 46 C c NN cord-302530-pp6bl941 36 47 up up IN cord-302530-pp6bl941 36 48 to to TO cord-302530-pp6bl941 36 49 44 44 CD cord-302530-pp6bl941 36 50 ° ° NN cord-302530-pp6bl941 36 51 C c NN cord-302530-pp6bl941 36 52 in in IN cord-302530-pp6bl941 36 53 the the DT cord-302530-pp6bl941 36 54 case case NN cord-302530-pp6bl941 36 55 of of IN cord-302530-pp6bl941 36 56 West West NNP cord-302530-pp6bl941 36 57 Nile Nile NNP cord-302530-pp6bl941 36 58 virus virus NN cord-302530-pp6bl941 36 59 ( ( -LRB- cord-302530-pp6bl941 36 60 WNV WNV NNP cord-302530-pp6bl941 36 61 ) ) -RRB- cord-302530-pp6bl941 36 62 in in IN cord-302530-pp6bl941 36 63 infected infected JJ cord-302530-pp6bl941 36 64 American american JJ cord-302530-pp6bl941 36 65 crows crow NNS cord-302530-pp6bl941 36 66 ( ( -LRB- cord-302530-pp6bl941 36 67 Corvus Corvus NNP cord-302530-pp6bl941 36 68 brachyrhynchos brachyrhynchos NNP cord-302530-pp6bl941 36 69 ) ) -RRB- cord-302530-pp6bl941 37 1 ( ( -LRB- cord-302530-pp6bl941 37 2 Kinney Kinney NNP cord-302530-pp6bl941 37 3 et et NNP cord-302530-pp6bl941 37 4 al al NNP cord-302530-pp6bl941 37 5 . . NNP cord-302530-pp6bl941 37 6 , , , cord-302530-pp6bl941 37 7 2006 2006 CD cord-302530-pp6bl941 37 8 ) ) -RRB- cord-302530-pp6bl941 37 9 . . . cord-302530-pp6bl941 38 1 Birds bird NNS cord-302530-pp6bl941 38 2 generally generally RB cord-302530-pp6bl941 38 3 have have VBP cord-302530-pp6bl941 38 4 higher high JJR cord-302530-pp6bl941 38 5 body body NN cord-302530-pp6bl941 38 6 temperatures temperature NNS cord-302530-pp6bl941 38 7 than than IN cord-302530-pp6bl941 38 8 mammals mammal NNS cord-302530-pp6bl941 38 9 ( ( -LRB- cord-302530-pp6bl941 38 10 Brault Brault NNP cord-302530-pp6bl941 38 11 2009 2009 CD cord-302530-pp6bl941 38 12 ) ) -RRB- cord-302530-pp6bl941 38 13 and and CC cord-302530-pp6bl941 38 14 the the DT cord-302530-pp6bl941 38 15 avian avian JJ cord-302530-pp6bl941 38 16 influenza influenza NN cord-302530-pp6bl941 38 17 virus virus NN cord-302530-pp6bl941 38 18 ( ( -LRB- cord-302530-pp6bl941 38 19 AIV AIV NNP cord-302530-pp6bl941 38 20 ) ) -RRB- cord-302530-pp6bl941 38 21 when when WRB cord-302530-pp6bl941 38 22 jumping jump VBG cord-302530-pp6bl941 38 23 from from IN cord-302530-pp6bl941 38 24 birds bird NNS cord-302530-pp6bl941 38 25 to to IN cord-302530-pp6bl941 38 26 humans human NNS cord-302530-pp6bl941 38 27 has have VBZ cord-302530-pp6bl941 38 28 to to TO cord-302530-pp6bl941 38 29 adapt adapt VB cord-302530-pp6bl941 38 30 to to IN cord-302530-pp6bl941 38 31 a a DT cord-302530-pp6bl941 38 32 temperature temperature NN cord-302530-pp6bl941 38 33 drop drop NN cord-302530-pp6bl941 38 34 of of IN cord-302530-pp6bl941 38 35 8 8 CD cord-302530-pp6bl941 38 36 ° ° NN cord-302530-pp6bl941 38 37 C c NN cord-302530-pp6bl941 38 38 since since IN cord-302530-pp6bl941 38 39 the the DT cord-302530-pp6bl941 38 40 temperature temperature NN cord-302530-pp6bl941 38 41 in in IN cord-302530-pp6bl941 38 42 the the DT cord-302530-pp6bl941 38 43 human human JJ cord-302530-pp6bl941 38 44 upper upper JJ cord-302530-pp6bl941 38 45 respiratory respiratory JJ cord-302530-pp6bl941 38 46 tract tract NN cord-302530-pp6bl941 38 47 is be VBZ cord-302530-pp6bl941 39 1 33 33 CD cord-302530-pp6bl941 39 2 ° ° NN cord-302530-pp6bl941 39 3 C c NN cord-302530-pp6bl941 39 4 compared compare VBN cord-302530-pp6bl941 39 5 to~41 to~41 NNP cord-302530-pp6bl941 39 6 ° ° NN cord-302530-pp6bl941 39 7 C C NNP cord-302530-pp6bl941 39 8 in in IN cord-302530-pp6bl941 39 9 the the DT cord-302530-pp6bl941 39 10 avian avian JJ cord-302530-pp6bl941 39 11 intestinal intestinal JJ cord-302530-pp6bl941 39 12 tract tract NN cord-302530-pp6bl941 39 13 which which WDT cord-302530-pp6bl941 39 14 is be VBZ cord-302530-pp6bl941 39 15 the the DT cord-302530-pp6bl941 39 16 site site NN cord-302530-pp6bl941 39 17 of of IN cord-302530-pp6bl941 39 18 replication replication NN cord-302530-pp6bl941 39 19 of of IN cord-302530-pp6bl941 39 20 avian avian JJ cord-302530-pp6bl941 39 21 viruses virus NNS cord-302530-pp6bl941 39 22 ( ( -LRB- cord-302530-pp6bl941 39 23 De de FW cord-302530-pp6bl941 39 24 Graaf Graaf NNP cord-302530-pp6bl941 39 25 and and CC cord-302530-pp6bl941 39 26 Fouchier Fouchier NNP cord-302530-pp6bl941 39 27 , , , cord-302530-pp6bl941 39 28 2014 2014 CD cord-302530-pp6bl941 39 29 ) ) -RRB- cord-302530-pp6bl941 39 30 . . . cord-302530-pp6bl941 40 1 Bats bat NNS cord-302530-pp6bl941 40 2 have have VBP cord-302530-pp6bl941 40 3 higher high JJR cord-302530-pp6bl941 40 4 core core NN cord-302530-pp6bl941 40 5 body body NN cord-302530-pp6bl941 40 6 temperatures temperature NNS cord-302530-pp6bl941 40 7 than than IN cord-302530-pp6bl941 40 8 primates primate NNS cord-302530-pp6bl941 40 9 ( ( -LRB- cord-302530-pp6bl941 40 10 up up IN cord-302530-pp6bl941 40 11 to to IN cord-302530-pp6bl941 40 12 42.1 42.1 CD cord-302530-pp6bl941 40 13 ° ° NN cord-302530-pp6bl941 40 14 C c NN cord-302530-pp6bl941 40 15 for for IN cord-302530-pp6bl941 40 16 Phyllostomus Phyllostomus NNP cord-302530-pp6bl941 40 17 hastatus hastatus NNP cord-302530-pp6bl941 40 18 which which WDT cord-302530-pp6bl941 40 19 is be VBZ cord-302530-pp6bl941 40 20 an an DT cord-302530-pp6bl941 40 21 omnivorous omnivorous JJ cord-302530-pp6bl941 40 22 bat bat NN cord-302530-pp6bl941 40 23 from from IN cord-302530-pp6bl941 40 24 South South NNP cord-302530-pp6bl941 40 25 America America NNP cord-302530-pp6bl941 40 26 ) ) -RRB- cord-302530-pp6bl941 40 27 when when WRB cord-302530-pp6bl941 40 28 flying fly VBG cord-302530-pp6bl941 40 29 ( ( -LRB- cord-302530-pp6bl941 40 30 O'Shea O'Shea NNP cord-302530-pp6bl941 40 31 et et NNP cord-302530-pp6bl941 40 32 al al NNP cord-302530-pp6bl941 40 33 . . NNP cord-302530-pp6bl941 40 34 , , , cord-302530-pp6bl941 40 35 2014 2014 CD cord-302530-pp6bl941 40 36 ) ) -RRB- cord-302530-pp6bl941 40 37 . . . cord-302530-pp6bl941 41 1 The the DT cord-302530-pp6bl941 41 2 core core NN cord-302530-pp6bl941 41 3 body body NN cord-302530-pp6bl941 41 4 temperature temperature NN cord-302530-pp6bl941 41 5 during during IN cord-302530-pp6bl941 41 6 flight flight NN cord-302530-pp6bl941 41 7 of of IN cord-302530-pp6bl941 41 8 the the DT cord-302530-pp6bl941 41 9 insectivorous insectivorous JJ cord-302530-pp6bl941 41 10 free free JJ cord-302530-pp6bl941 41 11 - - HYPH cord-302530-pp6bl941 41 12 tailed tailed JJ cord-302530-pp6bl941 41 13 bat bat NN cord-302530-pp6bl941 41 14 ( ( -LRB- cord-302530-pp6bl941 41 15 Mops Mops NNP cord-302530-pp6bl941 41 16 condylurus condylurus NNP cord-302530-pp6bl941 41 17 ) ) -RRB- cord-302530-pp6bl941 41 18 which which WDT cord-302530-pp6bl941 41 19 may may MD cord-302530-pp6bl941 41 20 have have VB cord-302530-pp6bl941 41 21 been be VBN cord-302530-pp6bl941 41 22 the the DT cord-302530-pp6bl941 41 23 origin origin NN cord-302530-pp6bl941 41 24 of of IN cord-302530-pp6bl941 41 25 the the DT cord-302530-pp6bl941 41 26 2013/15 2013/15 CD cord-302530-pp6bl941 41 27 severe severe JJ cord-302530-pp6bl941 41 28 Zaire Zaire NNP cord-302530-pp6bl941 41 29 ebolavirus ebolavirus NN cord-302530-pp6bl941 41 30 ( ( -LRB- cord-302530-pp6bl941 41 31 EBOV EBOV NNP cord-302530-pp6bl941 41 32 ) ) -RRB- cord-302530-pp6bl941 41 33 outbreak outbreak NN cord-302530-pp6bl941 41 34 in in IN cord-302530-pp6bl941 41 35 West West NNP cord-302530-pp6bl941 41 36 Africa Africa NNP cord-302530-pp6bl941 42 1 ( ( -LRB- cord-302530-pp6bl941 42 2 Saez Saez NNP cord-302530-pp6bl941 42 3 et et FW cord-302530-pp6bl941 42 4 al al NNP cord-302530-pp6bl941 42 5 . . NNP cord-302530-pp6bl941 42 6 , , , cord-302530-pp6bl941 42 7 2015 2015 CD cord-302530-pp6bl941 42 8 ) ) -RRB- cord-302530-pp6bl941 42 9 is be VBZ cord-302530-pp6bl941 42 10 40.5 40.5 CD cord-302530-pp6bl941 42 11 ° ° NN cord-302530-pp6bl941 42 12 C C NNP cord-302530-pp6bl941 42 13 ± ± NNP cord-302530-pp6bl941 42 14 1 1 CD cord-302530-pp6bl941 42 15 ° ° NN cord-302530-pp6bl941 42 16 C C NNP cord-302530-pp6bl941 42 17 ( ( -LRB- cord-302530-pp6bl941 42 18 O'Shea O'Shea NNP cord-302530-pp6bl941 42 19 et et NNP cord-302530-pp6bl941 42 20 al al NNP cord-302530-pp6bl941 42 21 . . NNP cord-302530-pp6bl941 42 22 , , , cord-302530-pp6bl941 42 23 2014 2014 CD cord-302530-pp6bl941 42 24 ) ) -RRB- cord-302530-pp6bl941 42 25 . . . cord-302530-pp6bl941 43 1 Thus thus RB cord-302530-pp6bl941 43 2 EBOV EBOV NNP cord-302530-pp6bl941 43 3 which which WDT cord-302530-pp6bl941 43 4 infects infect VBZ cord-302530-pp6bl941 43 5 a a DT cord-302530-pp6bl941 43 6 range range NN cord-302530-pp6bl941 43 7 of of IN cord-302530-pp6bl941 43 8 vertebrate vertebrate JJ cord-302530-pp6bl941 43 9 species specie NNS cord-302530-pp6bl941 43 10 from from IN cord-302530-pp6bl941 43 11 bats bat NNS cord-302530-pp6bl941 43 12 to to IN cord-302530-pp6bl941 43 13 primates primate NNS cord-302530-pp6bl941 43 14 and and CC cord-302530-pp6bl941 43 15 deer deer NN cord-302530-pp6bl941 43 16 may may MD cord-302530-pp6bl941 43 17 have have VB cord-302530-pp6bl941 43 18 to to TO cord-302530-pp6bl941 43 19 infect infect VB cord-302530-pp6bl941 43 20 mammalian mammalian JJ cord-302530-pp6bl941 43 21 hosts host NNS cord-302530-pp6bl941 43 22 over over IN cord-302530-pp6bl941 43 23 a a DT cord-302530-pp6bl941 43 24 range range NN cord-302530-pp6bl941 43 25 of of IN cord-302530-pp6bl941 43 26 temperatures temperature NNS cord-302530-pp6bl941 43 27 . . . cord-302530-pp6bl941 44 1 Similarly similarly RB cord-302530-pp6bl941 44 2 Nipah Nipah NNP cord-302530-pp6bl941 44 3 virus virus NN cord-302530-pp6bl941 44 4 on on IN cord-302530-pp6bl941 44 5 jumping jump VBG cord-302530-pp6bl941 44 6 from from IN cord-302530-pp6bl941 44 7 fruit fruit NN cord-302530-pp6bl941 44 8 bats bat NNS cord-302530-pp6bl941 44 9 to to IN cord-302530-pp6bl941 44 10 pigs pig NNS cord-302530-pp6bl941 44 11 and and CC cord-302530-pp6bl941 44 12 humans human NNS cord-302530-pp6bl941 44 13 ( ( -LRB- cord-302530-pp6bl941 44 14 Daszak Daszak NNP cord-302530-pp6bl941 44 15 et et NNP cord-302530-pp6bl941 44 16 al al NNP cord-302530-pp6bl941 44 17 . . NNP cord-302530-pp6bl941 44 18 , , , cord-302530-pp6bl941 44 19 2013 2013 CD cord-302530-pp6bl941 44 20 ) ) -RRB- cord-302530-pp6bl941 44 21 may may MD cord-302530-pp6bl941 44 22 experience experience VB cord-302530-pp6bl941 44 23 a a DT cord-302530-pp6bl941 44 24 small small JJ cord-302530-pp6bl941 44 25 fall fall NN cord-302530-pp6bl941 44 26 in in IN cord-302530-pp6bl941 44 27 temperature temperature NN cord-302530-pp6bl941 44 28 . . . cord-302530-pp6bl941 45 1 Furthermore furthermore RB cord-302530-pp6bl941 45 2 , , , cord-302530-pp6bl941 45 3 cross cross JJ cord-302530-pp6bl941 45 4 - - JJ cord-302530-pp6bl941 45 5 species species JJ cord-302530-pp6bl941 45 6 transmission transmission NN cord-302530-pp6bl941 45 7 of of IN cord-302530-pp6bl941 45 8 viruses virus NNS cord-302530-pp6bl941 45 9 to to IN cord-302530-pp6bl941 45 10 bats bat NNS cord-302530-pp6bl941 45 11 ( ( -LRB- cord-302530-pp6bl941 45 12 and and CC cord-302530-pp6bl941 45 13 other other JJ cord-302530-pp6bl941 45 14 mammals mammal NNS cord-302530-pp6bl941 45 15 ) ) -RRB- cord-302530-pp6bl941 45 16 from from IN cord-302530-pp6bl941 45 17 invertebrates invertebrate NNS cord-302530-pp6bl941 45 18 may may MD cord-302530-pp6bl941 45 19 occur occur VB cord-302530-pp6bl941 45 20 with with IN cord-302530-pp6bl941 45 21 more more JJR cord-302530-pp6bl941 45 22 regularity regularity NN cord-302530-pp6bl941 45 23 than than IN cord-302530-pp6bl941 45 24 has have VBZ cord-302530-pp6bl941 45 25 been be VBN cord-302530-pp6bl941 45 26 appreciated appreciate VBN cord-302530-pp6bl941 45 27 ( ( -LRB- cord-302530-pp6bl941 45 28 Bennett Bennett NNP cord-302530-pp6bl941 45 29 et et NNP cord-302530-pp6bl941 45 30 al al NNP cord-302530-pp6bl941 45 31 . . NNP cord-302530-pp6bl941 45 32 , , , cord-302530-pp6bl941 45 33 2018 2018 CD cord-302530-pp6bl941 45 34 ; ; : cord-302530-pp6bl941 45 35 Leendertz Leendertz NNP cord-302530-pp6bl941 45 36 2016 2016 CD cord-302530-pp6bl941 45 37 ) ) -RRB- cord-302530-pp6bl941 45 38 , , , cord-302530-pp6bl941 45 39 and and CC cord-302530-pp6bl941 45 40 Bennett Bennett NNP cord-302530-pp6bl941 45 41 et et NNP cord-302530-pp6bl941 45 42 al al NNP cord-302530-pp6bl941 45 43 . . . cord-302530-pp6bl941 46 1 ( ( -LRB- cord-302530-pp6bl941 46 2 2018 2018 CD cord-302530-pp6bl941 46 3 ) ) -RRB- cord-302530-pp6bl941 46 4 have have VBP cord-302530-pp6bl941 46 5 suggested suggest VBN cord-302530-pp6bl941 46 6 that that IN cord-302530-pp6bl941 46 7 arthropods arthropod NNS cord-302530-pp6bl941 46 8 may may MD cord-302530-pp6bl941 46 9 host host VB cord-302530-pp6bl941 46 10 many many JJ cord-302530-pp6bl941 46 11 " " `` cord-302530-pp6bl941 46 12 bat bat NN cord-302530-pp6bl941 46 13 - - HYPH cord-302530-pp6bl941 46 14 associated associate VBN cord-302530-pp6bl941 46 15 " " '' cord-302530-pp6bl941 46 16 viruses virus NNS cord-302530-pp6bl941 46 17 that that WDT cord-302530-pp6bl941 46 18 have have VBP cord-302530-pp6bl941 46 19 defied defy VBN cord-302530-pp6bl941 46 20 detection detection NN cord-302530-pp6bl941 46 21 in in IN cord-302530-pp6bl941 46 22 bats bat NNS cord-302530-pp6bl941 46 23 themselves -PRON- PRP cord-302530-pp6bl941 46 24 ( ( -LRB- cord-302530-pp6bl941 46 25 e.g. e.g. RB cord-302530-pp6bl941 46 26 EBOV EBOV NNP cord-302530-pp6bl941 46 27 ) ) -RRB- cord-302530-pp6bl941 46 28 . . . cord-302530-pp6bl941 47 1 Depending depend VBG cord-302530-pp6bl941 47 2 on on IN cord-302530-pp6bl941 47 3 the the DT cord-302530-pp6bl941 47 4 ambient ambient JJ cord-302530-pp6bl941 47 5 temperature temperature NN cord-302530-pp6bl941 47 6 , , , cord-302530-pp6bl941 47 7 viruses virus NNS cord-302530-pp6bl941 47 8 in in IN cord-302530-pp6bl941 47 9 arthropods arthropod NNS cord-302530-pp6bl941 47 10 would would MD cord-302530-pp6bl941 47 11 experience experience VB cord-302530-pp6bl941 47 12 a a DT cord-302530-pp6bl941 47 13 9 9 CD cord-302530-pp6bl941 47 14 ° ° NN cord-302530-pp6bl941 47 15 C c NN cord-302530-pp6bl941 47 16 to to IN cord-302530-pp6bl941 47 17 15 15 CD cord-302530-pp6bl941 47 18 ° ° NN cord-302530-pp6bl941 47 19 C c NN cord-302530-pp6bl941 47 20 temperature temperature NN cord-302530-pp6bl941 47 21 increase increase NN cord-302530-pp6bl941 47 22 on on IN cord-302530-pp6bl941 47 23 being be VBG cord-302530-pp6bl941 47 24 ingested ingest VBN cord-302530-pp6bl941 47 25 by by IN cord-302530-pp6bl941 47 26 a a DT cord-302530-pp6bl941 47 27 bat bat NN cord-302530-pp6bl941 47 28 at at IN cord-302530-pp6bl941 47 29 41 41 CD cord-302530-pp6bl941 47 30 ° ° NN cord-302530-pp6bl941 47 31 C C NNP cord-302530-pp6bl941 47 32 ( ( -LRB- cord-302530-pp6bl941 47 33 Gale Gale NNP cord-302530-pp6bl941 47 34 2017 2017 CD cord-302530-pp6bl941 47 35 ) ) -RRB- cord-302530-pp6bl941 47 36 and and CC cord-302530-pp6bl941 47 37 this this DT cord-302530-pp6bl941 47 38 could could MD cord-302530-pp6bl941 47 39 affect affect VB cord-302530-pp6bl941 47 40 the the DT cord-302530-pp6bl941 47 41 binding bind VBG cord-302530-pp6bl941 47 42 affinity affinity NN cord-302530-pp6bl941 47 43 of of IN cord-302530-pp6bl941 47 44 the the DT cord-302530-pp6bl941 47 45 virus virus NN cord-302530-pp6bl941 47 46 to to IN cord-302530-pp6bl941 47 47 its -PRON- PRP$ cord-302530-pp6bl941 47 48 host host NN cord-302530-pp6bl941 47 49 cell cell NN cord-302530-pp6bl941 47 50 depending depend VBG cord-302530-pp6bl941 47 51 on on IN cord-302530-pp6bl941 47 52 the the DT cord-302530-pp6bl941 47 53 thermodynamics thermodynamic NNS cord-302530-pp6bl941 47 54 of of IN cord-302530-pp6bl941 47 55 virus virus NN cord-302530-pp6bl941 47 56 binding bind VBG cord-302530-pp6bl941 47 57 as as IN cord-302530-pp6bl941 47 58 is be VBZ cord-302530-pp6bl941 47 59 discussed discuss VBN cord-302530-pp6bl941 47 60 here here RB cord-302530-pp6bl941 47 61 . . . cord-302530-pp6bl941 48 1 In in IN cord-302530-pp6bl941 48 2 contrast contrast NN cord-302530-pp6bl941 48 3 other other JJ cord-302530-pp6bl941 48 4 viruses virus NNS cord-302530-pp6bl941 48 5 only only RB cord-302530-pp6bl941 48 6 infect infect VBP cord-302530-pp6bl941 48 7 related related JJ cord-302530-pp6bl941 48 8 host host NN cord-302530-pp6bl941 48 9 species specie NNS cord-302530-pp6bl941 48 10 , , , cord-302530-pp6bl941 48 11 and and CC cord-302530-pp6bl941 48 12 in in IN cord-302530-pp6bl941 48 13 effect effect NN cord-302530-pp6bl941 48 14 are be VBP cord-302530-pp6bl941 48 15 maintained maintain VBN cord-302530-pp6bl941 48 16 at at IN cord-302530-pp6bl941 48 17 similar similar JJ cord-302530-pp6bl941 48 18 temperatures temperature NNS cord-302530-pp6bl941 48 19 . . . cord-302530-pp6bl941 49 1 For for IN cord-302530-pp6bl941 49 2 example example NN cord-302530-pp6bl941 49 3 , , , cord-302530-pp6bl941 49 4 simian simian JJ cord-302530-pp6bl941 49 5 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 49 6 viruses virus NNS cord-302530-pp6bl941 49 7 ( ( -LRB- cord-302530-pp6bl941 49 8 SIV SIV NNP cord-302530-pp6bl941 49 9 ) ) -RRB- cord-302530-pp6bl941 49 10 infect infect VBP cord-302530-pp6bl941 49 11 36 36 CD cord-302530-pp6bl941 49 12 different different JJ cord-302530-pp6bl941 49 13 nonhuman nonhuman NN cord-302530-pp6bl941 49 14 primate primate NN cord-302530-pp6bl941 49 15 species specie NNS cord-302530-pp6bl941 49 16 in in IN cord-302530-pp6bl941 49 17 sub sub JJ cord-302530-pp6bl941 49 18 - - JJ cord-302530-pp6bl941 49 19 Saharan saharan JJ cord-302530-pp6bl941 49 20 Africa Africa NNP cord-302530-pp6bl941 49 21 and and CC cord-302530-pp6bl941 49 22 SIVs siv NNS cord-302530-pp6bl941 49 23 from from IN cord-302530-pp6bl941 49 24 chimpanzees chimpanzee NNS cord-302530-pp6bl941 49 25 ( ( -LRB- cord-302530-pp6bl941 49 26 Pan Pan NNP cord-302530-pp6bl941 49 27 troglodytes troglodyte NNS cord-302530-pp6bl941 49 28 ) ) -RRB- cord-302530-pp6bl941 49 29 have have VBP cord-302530-pp6bl941 49 30 crossed cross VBN cord-302530-pp6bl941 49 31 species species NN cord-302530-pp6bl941 49 32 barriers barrier NNS cord-302530-pp6bl941 49 33 on on IN cord-302530-pp6bl941 49 34 multiple multiple JJ cord-302530-pp6bl941 49 35 occasions occasion NNS cord-302530-pp6bl941 49 36 generating generate VBG cord-302530-pp6bl941 49 37 human human JJ cord-302530-pp6bl941 49 38 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 49 39 virus virus NN cord-302530-pp6bl941 49 40 ( ( -LRB- cord-302530-pp6bl941 49 41 HIV HIV NNP cord-302530-pp6bl941 49 42 ) ) -RRB- cord-302530-pp6bl941 49 43 types type NNS cord-302530-pp6bl941 49 44 1 1 CD cord-302530-pp6bl941 49 45 and and CC cord-302530-pp6bl941 49 46 2 2 CD cord-302530-pp6bl941 50 1 ( ( -LRB- cord-302530-pp6bl941 50 2 Sharp Sharp NNP cord-302530-pp6bl941 50 3 et et FW cord-302530-pp6bl941 50 4 al al NNP cord-302530-pp6bl941 50 5 . . NNP cord-302530-pp6bl941 50 6 , , , cord-302530-pp6bl941 50 7 2005 2005 CD cord-302530-pp6bl941 50 8 ) ) -RRB- cord-302530-pp6bl941 50 9 . . . cord-302530-pp6bl941 51 1 Thus thus RB cord-302530-pp6bl941 51 2 the the DT cord-302530-pp6bl941 51 3 main main JJ cord-302530-pp6bl941 51 4 source source NN cord-302530-pp6bl941 51 5 of of IN cord-302530-pp6bl941 51 6 temperature temperature NN cord-302530-pp6bl941 51 7 variation variation NN cord-302530-pp6bl941 51 8 experienced experience VBN cord-302530-pp6bl941 51 9 by by IN cord-302530-pp6bl941 51 10 SIV SIV NNP cord-302530-pp6bl941 51 11 and and CC cord-302530-pp6bl941 51 12 HIV HIV NNP cord-302530-pp6bl941 51 13 would would MD cord-302530-pp6bl941 51 14 be be VB cord-302530-pp6bl941 51 15 the the DT cord-302530-pp6bl941 51 16 effect effect NN cord-302530-pp6bl941 51 17 of of IN cord-302530-pp6bl941 51 18 the the DT cord-302530-pp6bl941 51 19 circadian circadian NN cord-302530-pp6bl941 51 20 rhythm rhythm NN cord-302530-pp6bl941 51 21 and and CC cord-302530-pp6bl941 51 22 the the DT cord-302530-pp6bl941 51 23 slight slight JJ cord-302530-pp6bl941 51 24 rise rise NN cord-302530-pp6bl941 51 25 in in IN cord-302530-pp6bl941 51 26 temperature temperature NN cord-302530-pp6bl941 51 27 due due IN cord-302530-pp6bl941 51 28 to to IN cord-302530-pp6bl941 51 29 infection infection NN cord-302530-pp6bl941 51 30 of of IN cord-302530-pp6bl941 51 31 the the DT cord-302530-pp6bl941 51 32 host host NN cord-302530-pp6bl941 51 33 which which WDT cord-302530-pp6bl941 51 34 gives give VBZ cord-302530-pp6bl941 51 35 a a DT cord-302530-pp6bl941 51 36 range range NN cord-302530-pp6bl941 51 37 of of IN cord-302530-pp6bl941 51 38 36 36 CD cord-302530-pp6bl941 51 39 ° ° NN cord-302530-pp6bl941 51 40 C c NN cord-302530-pp6bl941 51 41 to to IN cord-302530-pp6bl941 51 42 38 38 CD cord-302530-pp6bl941 51 43 ° ° NN cord-302530-pp6bl941 51 44 C c NN cord-302530-pp6bl941 51 45 in in IN cord-302530-pp6bl941 51 46 the the DT cord-302530-pp6bl941 51 47 case case NN cord-302530-pp6bl941 51 48 of of IN cord-302530-pp6bl941 51 49 Rhesus Rhesus NNP cord-302530-pp6bl941 51 50 monkeys monkey NNS cord-302530-pp6bl941 51 51 ( ( -LRB- cord-302530-pp6bl941 51 52 Huitron Huitron NNP cord-302530-pp6bl941 51 53 - - HYPH cord-302530-pp6bl941 51 54 Resendiz Resendiz NNP cord-302530-pp6bl941 51 55 et et NNP cord-302530-pp6bl941 51 56 al al NNP cord-302530-pp6bl941 51 57 . . NNP cord-302530-pp6bl941 51 58 , , , cord-302530-pp6bl941 51 59 2007 2007 CD cord-302530-pp6bl941 51 60 ) ) -RRB- cord-302530-pp6bl941 51 61 . . . cord-302530-pp6bl941 52 1 Viruses virus NNS cord-302530-pp6bl941 52 2 bind bind VBP cord-302530-pp6bl941 52 3 to to TO cord-302530-pp6bl941 52 4 host host NN cord-302530-pp6bl941 52 5 cells cell NNS cord-302530-pp6bl941 52 6 through through IN cord-302530-pp6bl941 52 7 interactions interaction NNS cord-302530-pp6bl941 52 8 between between IN cord-302530-pp6bl941 52 9 a a DT cord-302530-pp6bl941 52 10 virus virus NN cord-302530-pp6bl941 52 11 surface surface NN cord-302530-pp6bl941 52 12 ( ( -LRB- cord-302530-pp6bl941 52 13 glyco)protein glyco)protein NNP cord-302530-pp6bl941 52 14 ( ( -LRB- cord-302530-pp6bl941 52 15 GP GP NNP cord-302530-pp6bl941 52 16 ) ) -RRB- cord-302530-pp6bl941 52 17 and and CC cord-302530-pp6bl941 52 18 a a DT cord-302530-pp6bl941 52 19 host host NN cord-302530-pp6bl941 52 20 cell cell NN cord-302530-pp6bl941 52 21 receptor receptor NN cord-302530-pp6bl941 52 22 ( ( -LRB- cord-302530-pp6bl941 52 23 Cr Cr NNP cord-302530-pp6bl941 52 24 ) ) -RRB- cord-302530-pp6bl941 52 25 . . . cord-302530-pp6bl941 53 1 The the DT cord-302530-pp6bl941 53 2 Cr Cr NNP cord-302530-pp6bl941 53 3 molecule molecule NN cord-302530-pp6bl941 53 4 on on IN cord-302530-pp6bl941 53 5 the the DT cord-302530-pp6bl941 53 6 cell cell NN cord-302530-pp6bl941 53 7 surface surface NN cord-302530-pp6bl941 53 8 may may MD cord-302530-pp6bl941 53 9 be be VB cord-302530-pp6bl941 53 10 a a DT cord-302530-pp6bl941 53 11 protein protein NN cord-302530-pp6bl941 53 12 as as IN cord-302530-pp6bl941 53 13 in in IN cord-302530-pp6bl941 53 14 the the DT cord-302530-pp6bl941 53 15 case case NN cord-302530-pp6bl941 53 16 of of IN cord-302530-pp6bl941 53 17 HIV HIV NNP cord-302530-pp6bl941 53 18 ( ( -LRB- cord-302530-pp6bl941 53 19 Myszka Myszka NNP cord-302530-pp6bl941 53 20 et et NNP cord-302530-pp6bl941 53 21 al al NNP cord-302530-pp6bl941 53 22 . . NNP cord-302530-pp6bl941 53 23 , , , cord-302530-pp6bl941 53 24 2000 2000 CD cord-302530-pp6bl941 53 25 ) ) -RRB- cord-302530-pp6bl941 53 26 , , , cord-302530-pp6bl941 53 27 EBOV EBOV NNP cord-302530-pp6bl941 53 28 ( ( -LRB- cord-302530-pp6bl941 53 29 Yuan Yuan NNP cord-302530-pp6bl941 53 30 et et FW cord-302530-pp6bl941 53 31 al al NNP cord-302530-pp6bl941 53 32 . . NNP cord-302530-pp6bl941 53 33 , , , cord-302530-pp6bl941 53 34 2015 2015 CD cord-302530-pp6bl941 53 35 ) ) -RRB- cord-302530-pp6bl941 53 36 , , , cord-302530-pp6bl941 53 37 Hendra Hendra NNP cord-302530-pp6bl941 53 38 virus virus NN cord-302530-pp6bl941 53 39 ( ( -LRB- cord-302530-pp6bl941 53 40 Xu Xu NNP cord-302530-pp6bl941 53 41 et et NNP cord-302530-pp6bl941 53 42 al al NNP cord-302530-pp6bl941 53 43 . . NNP cord-302530-pp6bl941 53 44 , , , cord-302530-pp6bl941 53 45 2012 2012 CD cord-302530-pp6bl941 53 46 ) ) -RRB- cord-302530-pp6bl941 53 47 and and CC cord-302530-pp6bl941 53 48 MERS MERS NNP cord-302530-pp6bl941 53 49 - - HYPH cord-302530-pp6bl941 53 50 CoV CoV NNP cord-302530-pp6bl941 53 51 ( ( -LRB- cord-302530-pp6bl941 53 52 Lu Lu NNP cord-302530-pp6bl941 53 53 et et FW cord-302530-pp6bl941 53 54 al al NNP cord-302530-pp6bl941 53 55 . . NNP cord-302530-pp6bl941 53 56 , , , cord-302530-pp6bl941 53 57 2013 2013 CD cord-302530-pp6bl941 53 58 ) ) -RRB- cord-302530-pp6bl941 53 59 or or CC cord-302530-pp6bl941 53 60 alternatively alternatively RB cord-302530-pp6bl941 53 61 is be VBZ cord-302530-pp6bl941 53 62 a a DT cord-302530-pp6bl941 53 63 sialic sialic JJ cord-302530-pp6bl941 53 64 acid acid NN cord-302530-pp6bl941 53 65 ( ( -LRB- cord-302530-pp6bl941 53 66 SA SA NNP cord-302530-pp6bl941 53 67 ) ) -RRB- cord-302530-pp6bl941 53 68 on on IN cord-302530-pp6bl941 53 69 a a DT cord-302530-pp6bl941 53 70 glycan glycan NN cord-302530-pp6bl941 53 71 as as IN cord-302530-pp6bl941 53 72 in in IN cord-302530-pp6bl941 53 73 the the DT cord-302530-pp6bl941 53 74 case case NN cord-302530-pp6bl941 53 75 of of IN cord-302530-pp6bl941 53 76 AIV AIV NNP cord-302530-pp6bl941 53 77 ( ( -LRB- cord-302530-pp6bl941 53 78 De De NNP cord-302530-pp6bl941 53 79 Graaf Graaf NNP cord-302530-pp6bl941 53 80 and and CC cord-302530-pp6bl941 53 81 Fouchier Fouchier NNP cord-302530-pp6bl941 53 82 , , , cord-302530-pp6bl941 53 83 2014 2014 CD cord-302530-pp6bl941 53 84 ; ; : cord-302530-pp6bl941 53 85 Fei Fei NNP cord-302530-pp6bl941 53 86 et et NNP cord-302530-pp6bl941 53 87 al al NNP cord-302530-pp6bl941 53 88 . . NNP cord-302530-pp6bl941 53 89 , , , cord-302530-pp6bl941 53 90 2015 2015 CD cord-302530-pp6bl941 53 91 ) ) -RRB- cord-302530-pp6bl941 53 92 and and CC cord-302530-pp6bl941 53 93 arboviruses arbovirus NNS cord-302530-pp6bl941 53 94 such such JJ cord-302530-pp6bl941 53 95 as as IN cord-302530-pp6bl941 53 96 bluetongue bluetongue NN cord-302530-pp6bl941 53 97 virus virus NN cord-302530-pp6bl941 53 98 ( ( -LRB- cord-302530-pp6bl941 53 99 BTV BTV NNP cord-302530-pp6bl941 53 100 ) ) -RRB- cord-302530-pp6bl941 54 1 ( ( -LRB- cord-302530-pp6bl941 54 2 Zhang Zhang NNP cord-302530-pp6bl941 54 3 et et NNP cord-302530-pp6bl941 54 4 al al NNP cord-302530-pp6bl941 54 5 . . NNP cord-302530-pp6bl941 54 6 , , , cord-302530-pp6bl941 54 7 2010 2010 CD cord-302530-pp6bl941 54 8 ) ) -RRB- cord-302530-pp6bl941 54 9 . . . cord-302530-pp6bl941 55 1 The the DT cord-302530-pp6bl941 55 2 thermodynamics thermodynamic NNS cord-302530-pp6bl941 55 3 of of IN cord-302530-pp6bl941 55 4 virus virus NN cord-302530-pp6bl941 55 5 binding bind VBG cord-302530-pp6bl941 55 6 in in IN cord-302530-pp6bl941 55 7 terms term NNS cord-302530-pp6bl941 55 8 of of IN cord-302530-pp6bl941 55 9 the the DT cord-302530-pp6bl941 55 10 changes change NNS cord-302530-pp6bl941 55 11 in in IN cord-302530-pp6bl941 55 12 enthalpy enthalpy NN cord-302530-pp6bl941 55 13 ( ( -LRB- cord-302530-pp6bl941 55 14 ΔH ΔH NNP cord-302530-pp6bl941 55 15 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 55 16 ) ) -RRB- cord-302530-pp6bl941 55 17 and and CC cord-302530-pp6bl941 55 18 entropy entropy NN cord-302530-pp6bl941 55 19 ( ( -LRB- cord-302530-pp6bl941 55 20 ΔS ΔS NNP cord-302530-pp6bl941 55 21 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 55 22 ) ) -RRB- cord-302530-pp6bl941 55 23 on on IN cord-302530-pp6bl941 55 24 the the DT cord-302530-pp6bl941 55 25 specific specific JJ cord-302530-pp6bl941 55 26 interaction interaction NN cord-302530-pp6bl941 55 27 of of IN cord-302530-pp6bl941 55 28 the the DT cord-302530-pp6bl941 55 29 GP gp NN cord-302530-pp6bl941 55 30 with with IN cord-302530-pp6bl941 55 31 the the DT cord-302530-pp6bl941 55 32 Cr Cr NNP cord-302530-pp6bl941 55 33 receptor receptor NN cord-302530-pp6bl941 55 34 at at IN cord-302530-pp6bl941 55 35 temperature temperature NN cord-302530-pp6bl941 55 36 T t NN cord-302530-pp6bl941 55 37 during during IN cord-302530-pp6bl941 55 38 binding binding NN cord-302530-pp6bl941 55 39 of of IN cord-302530-pp6bl941 55 40 virus virus NN cord-302530-pp6bl941 55 41 to to IN cord-302530-pp6bl941 55 42 the the DT cord-302530-pp6bl941 55 43 host host NN cord-302530-pp6bl941 55 44 cell cell NN cord-302530-pp6bl941 55 45 surface surface NN cord-302530-pp6bl941 55 46 has have VBZ cord-302530-pp6bl941 55 47 been be VBN cord-302530-pp6bl941 55 48 set set VBN cord-302530-pp6bl941 55 49 out out RP cord-302530-pp6bl941 55 50 previously previously RB cord-302530-pp6bl941 55 51 ( ( -LRB- cord-302530-pp6bl941 55 52 Gale Gale NNP cord-302530-pp6bl941 55 53 2018 2018 CD cord-302530-pp6bl941 56 1 ( ( -LRB- cord-302530-pp6bl941 56 2 Gale Gale NNP cord-302530-pp6bl941 56 3 , , , cord-302530-pp6bl941 56 4 2019 2019 CD cord-302530-pp6bl941 56 5 . . . cord-302530-pp6bl941 57 1 The the DT cord-302530-pp6bl941 57 2 interactions interaction NNS cord-302530-pp6bl941 57 3 between between IN cord-302530-pp6bl941 57 4 the the DT cord-302530-pp6bl941 57 5 HIV HIV NNP cord-302530-pp6bl941 57 6 GP GP NNP cord-302530-pp6bl941 57 7 and and CC cord-302530-pp6bl941 57 8 its -PRON- PRP$ cord-302530-pp6bl941 57 9 CD4 CD4 NNP cord-302530-pp6bl941 57 10 cellular cellular JJ cord-302530-pp6bl941 57 11 receptor receptor NN cord-302530-pp6bl941 57 12 ( ( -LRB- cord-302530-pp6bl941 57 13 Myszka Myszka NNP cord-302530-pp6bl941 57 14 et et NNP cord-302530-pp6bl941 57 15 al al NNP cord-302530-pp6bl941 57 16 . . NNP cord-302530-pp6bl941 57 17 , , , cord-302530-pp6bl941 57 18 2000 2000 CD cord-302530-pp6bl941 57 19 ; ; : cord-302530-pp6bl941 57 20 Dey Dey NNP cord-302530-pp6bl941 57 21 et et NNP cord-302530-pp6bl941 57 22 al al NNP cord-302530-pp6bl941 57 23 . . NNP cord-302530-pp6bl941 57 24 , , , cord-302530-pp6bl941 57 25 2007 2007 CD cord-302530-pp6bl941 57 26 ) ) -RRB- cord-302530-pp6bl941 57 27 and and CC cord-302530-pp6bl941 57 28 between between IN cord-302530-pp6bl941 57 29 the the DT cord-302530-pp6bl941 57 30 AIV AIV NNP cord-302530-pp6bl941 57 31 haemagglutinin haemagglutinin NNP cord-302530-pp6bl941 57 32 ( ( -LRB- cord-302530-pp6bl941 57 33 HA HA NNP cord-302530-pp6bl941 57 34 ) ) -RRB- cord-302530-pp6bl941 57 35 and and CC cord-302530-pp6bl941 57 36 its -PRON- PRP$ cord-302530-pp6bl941 57 37 α2,3-SA α2,3-sa NN cord-302530-pp6bl941 57 38 or or CC cord-302530-pp6bl941 57 39 α2,6-SA α2,6-sa NN cord-302530-pp6bl941 57 40 receptors receptor NNS cord-302530-pp6bl941 57 41 ( ( -LRB- cord-302530-pp6bl941 57 42 Fei Fei NNP cord-302530-pp6bl941 57 43 et et NNP cord-302530-pp6bl941 57 44 al al NNP cord-302530-pp6bl941 57 45 . . NNP cord-302530-pp6bl941 57 46 , , , cord-302530-pp6bl941 57 47 2015 2015 CD cord-302530-pp6bl941 57 48 ) ) -RRB- cord-302530-pp6bl941 57 49 are be VBP cord-302530-pp6bl941 57 50 enthalpy enthalpy JJ cord-302530-pp6bl941 57 51 driven drive VBN cord-302530-pp6bl941 57 52 , , , cord-302530-pp6bl941 57 53 i.e. i.e. FW cord-302530-pp6bl941 57 54 large large JJ cord-302530-pp6bl941 57 55 negative negative JJ cord-302530-pp6bl941 57 56 values value NNS cord-302530-pp6bl941 57 57 of of IN cord-302530-pp6bl941 57 58 ΔH ΔH NNP cord-302530-pp6bl941 57 59 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 57 60 overcome overcome VB cord-302530-pp6bl941 57 61 unfavourable unfavourable JJ cord-302530-pp6bl941 57 62 values value NNS cord-302530-pp6bl941 57 63 of of IN cord-302530-pp6bl941 57 64 ΔS ΔS NNP cord-302530-pp6bl941 57 65 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 57 66 . . . cord-302530-pp6bl941 58 1 Also also RB cord-302530-pp6bl941 58 2 the the DT cord-302530-pp6bl941 58 3 binding binding NN cord-302530-pp6bl941 58 4 of of IN cord-302530-pp6bl941 58 5 vesicular vesicular JJ cord-302530-pp6bl941 58 6 stomatitis stomatitis NN cord-302530-pp6bl941 58 7 virus virus NN cord-302530-pp6bl941 58 8 to to IN cord-302530-pp6bl941 58 9 phospholipid phospholipid NN cord-302530-pp6bl941 58 10 bilayers bilayer NNS cord-302530-pp6bl941 58 11 is be VBZ cord-302530-pp6bl941 58 12 enthalpy enthalpy JJ cord-302530-pp6bl941 58 13 driven drive VBN cord-302530-pp6bl941 58 14 ( ( -LRB- cord-302530-pp6bl941 58 15 Carneio Carneio NNP cord-302530-pp6bl941 58 16 et et NNP cord-302530-pp6bl941 58 17 al al NNP cord-302530-pp6bl941 58 18 . . . cord-302530-pp6bl941 58 19 2002 2002 CD cord-302530-pp6bl941 58 20 ) ) -RRB- cord-302530-pp6bl941 58 21 with with IN cord-302530-pp6bl941 58 22 very very RB cord-302530-pp6bl941 58 23 large large JJ cord-302530-pp6bl941 58 24 negative negative JJ cord-302530-pp6bl941 58 25 values value NNS cord-302530-pp6bl941 58 26 of of IN cord-302530-pp6bl941 58 27 ΔH ΔH NNP cord-302530-pp6bl941 58 28 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 58 29 . . . cord-302530-pp6bl941 59 1 Temperature temperature NN cord-302530-pp6bl941 59 2 may may MD cord-302530-pp6bl941 59 3 impose impose VB cord-302530-pp6bl941 59 4 constraints constraint NNS cord-302530-pp6bl941 59 5 on on IN cord-302530-pp6bl941 59 6 viruses virus NNS cord-302530-pp6bl941 59 7 ' ' POS cord-302530-pp6bl941 59 8 jumping jump VBG cord-302530-pp6bl941 59 9 the the DT cord-302530-pp6bl941 59 10 species specie NNS cord-302530-pp6bl941 59 11 barrier barrier NN cord-302530-pp6bl941 59 12 through through IN cord-302530-pp6bl941 59 13 its -PRON- PRP$ cord-302530-pp6bl941 59 14 effect effect NN cord-302530-pp6bl941 59 15 on on IN cord-302530-pp6bl941 59 16 the the DT cord-302530-pp6bl941 59 17 binding bind VBG cord-302530-pp6bl941 59 18 affinity affinity NN cord-302530-pp6bl941 59 19 of of IN cord-302530-pp6bl941 59 20 GP gp NN cord-302530-pp6bl941 59 21 to to IN cord-302530-pp6bl941 59 22 Cr cr NN cord-302530-pp6bl941 59 23 . . . cord-302530-pp6bl941 60 1 There there EX cord-302530-pp6bl941 60 2 may may MD cord-302530-pp6bl941 60 3 also also RB cord-302530-pp6bl941 60 4 be be VB cord-302530-pp6bl941 60 5 constraints constraint NNS cord-302530-pp6bl941 60 6 on on IN cord-302530-pp6bl941 60 7 the the DT cord-302530-pp6bl941 60 8 activities activity NNS cord-302530-pp6bl941 60 9 of of IN cord-302530-pp6bl941 60 10 viral viral JJ cord-302530-pp6bl941 60 11 replication replication NN cord-302530-pp6bl941 60 12 proteins protein NNS cord-302530-pp6bl941 60 13 such such JJ cord-302530-pp6bl941 60 14 as as IN cord-302530-pp6bl941 60 15 the the DT cord-302530-pp6bl941 60 16 AIV AIV NNP cord-302530-pp6bl941 60 17 polymerase polymerase NN cord-302530-pp6bl941 60 18 which which WDT cord-302530-pp6bl941 60 19 showed show VBD cord-302530-pp6bl941 60 20 a a DT cord-302530-pp6bl941 60 21 significantly significantly RB cord-302530-pp6bl941 60 22 higher high JJR cord-302530-pp6bl941 60 23 activity activity NN cord-302530-pp6bl941 60 24 at at IN cord-302530-pp6bl941 60 25 33 33 CD cord-302530-pp6bl941 60 26 ° ° NN cord-302530-pp6bl941 60 27 C c NN cord-302530-pp6bl941 60 28 than than IN cord-302530-pp6bl941 60 29 37 37 CD cord-302530-pp6bl941 60 30 ° ° NN cord-302530-pp6bl941 60 31 C c NN cord-302530-pp6bl941 60 32 ( ( -LRB- cord-302530-pp6bl941 60 33 Ngai Ngai NNP cord-302530-pp6bl941 60 34 et et NNP cord-302530-pp6bl941 60 35 al al NNP cord-302530-pp6bl941 60 36 . . NNP cord-302530-pp6bl941 60 37 , , , cord-302530-pp6bl941 60 38 2013 2013 CD cord-302530-pp6bl941 60 39 ) ) -RRB- cord-302530-pp6bl941 60 40 . . . cord-302530-pp6bl941 61 1 Only only RB cord-302530-pp6bl941 61 2 virus virus NN cord-302530-pp6bl941 61 3 binding binding NN cord-302530-pp6bl941 61 4 is be VBZ cord-302530-pp6bl941 61 5 considered consider VBN cord-302530-pp6bl941 61 6 here here RB cord-302530-pp6bl941 61 7 . . . cord-302530-pp6bl941 62 1 Thus thus RB cord-302530-pp6bl941 62 2 according accord VBG cord-302530-pp6bl941 62 3 to to IN cord-302530-pp6bl941 62 4 the the DT cord-302530-pp6bl941 62 5 Van't Van't NNPS cord-302530-pp6bl941 62 6 Hoff Hoff NNP cord-302530-pp6bl941 62 7 Isochore Isochore NNP cord-302530-pp6bl941 62 8 , , , cord-302530-pp6bl941 62 9 the the DT cord-302530-pp6bl941 62 10 binding bind VBG cord-302530-pp6bl941 62 11 affinity affinity NN cord-302530-pp6bl941 62 12 for for IN cord-302530-pp6bl941 62 13 a a DT cord-302530-pp6bl941 62 14 virus virus NN cord-302530-pp6bl941 62 15 to to IN cord-302530-pp6bl941 62 16 its -PRON- PRP$ cord-302530-pp6bl941 62 17 host host NN cord-302530-pp6bl941 62 18 cell cell NN cord-302530-pp6bl941 62 19 at at IN cord-302530-pp6bl941 62 20 temperature temperature NN cord-302530-pp6bl941 62 21 T T NNP cord-302530-pp6bl941 62 22 as as IN cord-302530-pp6bl941 62 23 represented represent VBN cord-302530-pp6bl941 62 24 by by IN cord-302530-pp6bl941 62 25 the the DT cord-302530-pp6bl941 62 26 association association NN cord-302530-pp6bl941 62 27 constant constant JJ cord-302530-pp6bl941 62 28 K K NNP cord-302530-pp6bl941 62 29 a_virus_T a_virus_T NNP cord-302530-pp6bl941 62 30 would would MD cord-302530-pp6bl941 62 31 be be VB cord-302530-pp6bl941 62 32 greatly greatly RB cord-302530-pp6bl941 62 33 diminished diminish VBN cord-302530-pp6bl941 62 34 for for IN cord-302530-pp6bl941 62 35 enthalpydriven enthalpydriven JJ cord-302530-pp6bl941 62 36 GP GP NNP cord-302530-pp6bl941 62 37 / / SYM cord-302530-pp6bl941 62 38 Cr cr NN cord-302530-pp6bl941 62 39 interactions interaction NNS cord-302530-pp6bl941 62 40 at at IN cord-302530-pp6bl941 62 41 higher high JJR cord-302530-pp6bl941 62 42 temperatures temperature NNS cord-302530-pp6bl941 62 43 compared compare VBN cord-302530-pp6bl941 62 44 to to IN cord-302530-pp6bl941 62 45 lower low JJR cord-302530-pp6bl941 62 46 temperatures temperature NNS cord-302530-pp6bl941 62 47 depending depend VBG cord-302530-pp6bl941 62 48 on on IN cord-302530-pp6bl941 62 49 the the DT cord-302530-pp6bl941 62 50 magnitude magnitude NN cord-302530-pp6bl941 62 51 of of IN cord-302530-pp6bl941 62 52 ΔH ΔH NNP cord-302530-pp6bl941 62 53 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 62 54 ( ( -LRB- cord-302530-pp6bl941 62 55 Gale Gale NNP cord-302530-pp6bl941 62 56 2019 2019 CD cord-302530-pp6bl941 62 57 ) ) -RRB- cord-302530-pp6bl941 62 58 . . . cord-302530-pp6bl941 63 1 Indeed indeed RB cord-302530-pp6bl941 63 2 , , , cord-302530-pp6bl941 63 3 assuming assume VBG cord-302530-pp6bl941 63 4 ΔH ΔH NNP cord-302530-pp6bl941 63 5 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 63 6 is be VBZ cord-302530-pp6bl941 63 7 constant constant JJ cord-302530-pp6bl941 63 8 over over IN cord-302530-pp6bl941 63 9 the the DT cord-302530-pp6bl941 63 10 temperature temperature NN cord-302530-pp6bl941 63 11 range range NN cord-302530-pp6bl941 63 12 , , , cord-302530-pp6bl941 63 13 the the DT cord-302530-pp6bl941 63 14 more more RBR cord-302530-pp6bl941 63 15 negative negative JJ cord-302530-pp6bl941 63 16 ΔH ΔH NNP cord-302530-pp6bl941 63 17 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 63 18 is be VBZ cord-302530-pp6bl941 63 19 in in IN cord-302530-pp6bl941 63 20 magnitude magnitude NN cord-302530-pp6bl941 63 21 , , , cord-302530-pp6bl941 63 22 the the DT cord-302530-pp6bl941 63 23 weaker weak JJR cord-302530-pp6bl941 63 24 the the DT cord-302530-pp6bl941 63 25 binding binding NN cord-302530-pp6bl941 63 26 at at IN cord-302530-pp6bl941 63 27 higher high JJR cord-302530-pp6bl941 63 28 temperatures temperature NNS cord-302530-pp6bl941 63 29 . . . cord-302530-pp6bl941 64 1 This this DT cord-302530-pp6bl941 64 2 presents present VBZ cord-302530-pp6bl941 64 3 a a DT cord-302530-pp6bl941 64 4 paradox paradox NN cord-302530-pp6bl941 65 1 if if IN cord-302530-pp6bl941 65 2 the the DT cord-302530-pp6bl941 65 3 K K NNP cord-302530-pp6bl941 65 4 a_virus_T a_virus_T NNP cord-302530-pp6bl941 65 5 falls fall VBZ cord-302530-pp6bl941 65 6 to to IN cord-302530-pp6bl941 65 7 less less RBR cord-302530-pp6bl941 65 8 than~10 than~10 NNP cord-302530-pp6bl941 65 9 14 14 CD cord-302530-pp6bl941 65 10 M M NNP cord-302530-pp6bl941 65 11 −1 −1 NNP cord-302530-pp6bl941 65 12 in in IN cord-302530-pp6bl941 65 13 that that IN cord-302530-pp6bl941 65 14 higher high JJR cord-302530-pp6bl941 65 15 temperatures temperature NNS cord-302530-pp6bl941 65 16 would would MD cord-302530-pp6bl941 65 17 greatly greatly RB cord-302530-pp6bl941 65 18 diminish diminish VB cord-302530-pp6bl941 65 19 infectivity infectivity NN cord-302530-pp6bl941 65 20 ( ( -LRB- cord-302530-pp6bl941 65 21 Gale Gale NNP cord-302530-pp6bl941 65 22 2019 2019 CD cord-302530-pp6bl941 65 23 ) ) -RRB- cord-302530-pp6bl941 65 24 . . . cord-302530-pp6bl941 66 1 While while IN cord-302530-pp6bl941 66 2 the the DT cord-302530-pp6bl941 66 3 values value NNS cord-302530-pp6bl941 66 4 of of IN cord-302530-pp6bl941 66 5 ΔH ΔH NNP cord-302530-pp6bl941 66 6 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 66 7 and and CC cord-302530-pp6bl941 66 8 ΔS ΔS NNP cord-302530-pp6bl941 66 9 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 66 10 may may MD cord-302530-pp6bl941 66 11 be be VB cord-302530-pp6bl941 66 12 constant constant JJ cord-302530-pp6bl941 66 13 over over IN cord-302530-pp6bl941 66 14 the the DT cord-302530-pp6bl941 66 15 biological biological JJ cord-302530-pp6bl941 66 16 temperature temperature NN cord-302530-pp6bl941 66 17 range range NN cord-302530-pp6bl941 66 18 for for IN cord-302530-pp6bl941 66 19 some some DT cord-302530-pp6bl941 66 20 GP GP NNP cord-302530-pp6bl941 66 21 / / SYM cord-302530-pp6bl941 66 22 Cr cr NN cord-302530-pp6bl941 66 23 systems system NNS cord-302530-pp6bl941 66 24 , , , cord-302530-pp6bl941 66 25 e.g. e.g. RB cord-302530-pp6bl941 66 26 AIV AIV NNP cord-302530-pp6bl941 66 27 haemagglutinin haemagglutinin NNP cord-302530-pp6bl941 66 28 ( ( -LRB- cord-302530-pp6bl941 66 29 HA HA NNP cord-302530-pp6bl941 66 30 ) ) -RRB- cord-302530-pp6bl941 66 31 binding bind VBG cord-302530-pp6bl941 66 32 to to IN cord-302530-pp6bl941 66 33 sialic sialic JJ cord-302530-pp6bl941 66 34 acid acid NN cord-302530-pp6bl941 66 35 ( ( -LRB- cord-302530-pp6bl941 66 36 SA sa NN cord-302530-pp6bl941 66 37 ) ) -RRB- cord-302530-pp6bl941 66 38 residues residue NNS cord-302530-pp6bl941 66 39 ( ( -LRB- cord-302530-pp6bl941 66 40 Fei Fei NNP cord-302530-pp6bl941 66 41 et et NNP cord-302530-pp6bl941 66 42 al al NNP cord-302530-pp6bl941 66 43 . . NNP cord-302530-pp6bl941 66 44 , , , cord-302530-pp6bl941 66 45 2015 2015 CD cord-302530-pp6bl941 66 46 ) ) -RRB- cord-302530-pp6bl941 67 1 they -PRON- PRP cord-302530-pp6bl941 67 2 may may MD cord-302530-pp6bl941 67 3 change change VB cord-302530-pp6bl941 67 4 considerably considerably RB cord-302530-pp6bl941 67 5 in in IN cord-302530-pp6bl941 67 6 magnitude magnitude NN cord-302530-pp6bl941 67 7 over over IN cord-302530-pp6bl941 67 8 the the DT cord-302530-pp6bl941 67 9 biologically biologically RB cord-302530-pp6bl941 67 10 relevant relevant JJ cord-302530-pp6bl941 67 11 temperature temperature NN cord-302530-pp6bl941 67 12 range range NN cord-302530-pp6bl941 67 13 particularly particularly RB cord-302530-pp6bl941 67 14 for for IN cord-302530-pp6bl941 67 15 protein protein NN cord-302530-pp6bl941 67 16 : : : cord-302530-pp6bl941 67 17 protein protein NN cord-302530-pp6bl941 67 18 systems system NNS cord-302530-pp6bl941 67 19 as as IN cord-302530-pp6bl941 67 20 in in IN cord-302530-pp6bl941 67 21 the the DT cord-302530-pp6bl941 67 22 case case NN cord-302530-pp6bl941 67 23 of of IN cord-302530-pp6bl941 67 24 HIV HIV NNP cord-302530-pp6bl941 67 25 gp120 gp120 NNP cord-302530-pp6bl941 67 26 binding bind VBG cord-302530-pp6bl941 67 27 to to IN cord-302530-pp6bl941 67 28 CD4 CD4 NNP cord-302530-pp6bl941 67 29 ( ( -LRB- cord-302530-pp6bl941 67 30 Myszka Myszka NNP cord-302530-pp6bl941 67 31 et et NNP cord-302530-pp6bl941 67 32 al al NNP cord-302530-pp6bl941 67 33 . . NNP cord-302530-pp6bl941 67 34 , , , cord-302530-pp6bl941 67 35 2000 2000 CD cord-302530-pp6bl941 67 36 ) ) -RRB- cord-302530-pp6bl941 68 1 ( ( -LRB- cord-302530-pp6bl941 68 2 Fig Fig NNP cord-302530-pp6bl941 68 3 . . . cord-302530-pp6bl941 69 1 1 1 LS cord-302530-pp6bl941 69 2 ) ) -RRB- cord-302530-pp6bl941 69 3 . . . cord-302530-pp6bl941 70 1 The the DT cord-302530-pp6bl941 70 2 effect effect NN cord-302530-pp6bl941 70 3 of of IN cord-302530-pp6bl941 70 4 this this DT cord-302530-pp6bl941 70 5 on on IN cord-302530-pp6bl941 70 6 K K NNP cord-302530-pp6bl941 70 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 70 8 is be VBZ cord-302530-pp6bl941 70 9 considered consider VBN cord-302530-pp6bl941 70 10 in in IN cord-302530-pp6bl941 70 11 this this DT cord-302530-pp6bl941 70 12 work work NN cord-302530-pp6bl941 70 13 . . . cord-302530-pp6bl941 71 1 The the DT cord-302530-pp6bl941 71 2 change change NN cord-302530-pp6bl941 71 3 in in IN cord-302530-pp6bl941 71 4 ΔH ΔH NNP cord-302530-pp6bl941 71 5 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 71 6 with with IN cord-302530-pp6bl941 71 7 temperature temperature NN cord-302530-pp6bl941 71 8 is be VBZ cord-302530-pp6bl941 71 9 defined define VBN cord-302530-pp6bl941 71 10 by by IN cord-302530-pp6bl941 71 11 the the DT cord-302530-pp6bl941 71 12 difference difference NN cord-302530-pp6bl941 71 13 in in IN cord-302530-pp6bl941 71 14 heat heat NN cord-302530-pp6bl941 71 15 capacities capacity NNS cord-302530-pp6bl941 71 16 ( ( -LRB- cord-302530-pp6bl941 71 17 C c NN cord-302530-pp6bl941 71 18 p p NN cord-302530-pp6bl941 71 19 ) ) -RRB- cord-302530-pp6bl941 71 20 of of IN cord-302530-pp6bl941 71 21 the the DT cord-302530-pp6bl941 71 22 GP GP NNP cord-302530-pp6bl941 71 23 / / SYM cord-302530-pp6bl941 71 24 Cr cr NN cord-302530-pp6bl941 71 25 " " `` cord-302530-pp6bl941 71 26 product product NN cord-302530-pp6bl941 71 27 " " '' cord-302530-pp6bl941 71 28 complex complex JJ cord-302530-pp6bl941 71 29 and and CC cord-302530-pp6bl941 71 30 the the DT cord-302530-pp6bl941 71 31 free free JJ cord-302530-pp6bl941 71 32 GP gp NN cord-302530-pp6bl941 71 33 / / SYM cord-302530-pp6bl941 71 34 free free JJ cord-302530-pp6bl941 71 35 host host NN cord-302530-pp6bl941 71 36 Cr Cr NNP cord-302530-pp6bl941 71 37 " " `` cord-302530-pp6bl941 71 38 reactants reactant NNS cord-302530-pp6bl941 71 39 " " '' cord-302530-pp6bl941 71 40 and and CC cord-302530-pp6bl941 71 41 is be VBZ cord-302530-pp6bl941 71 42 represented represent VBN cord-302530-pp6bl941 71 43 by by IN cord-302530-pp6bl941 71 44 ΔC ΔC NNP cord-302530-pp6bl941 71 45 p p NN cord-302530-pp6bl941 71 46 which which WDT cord-302530-pp6bl941 71 47 is be VBZ cord-302530-pp6bl941 71 48 the the DT cord-302530-pp6bl941 71 49 slope slope NN cord-302530-pp6bl941 71 50 of of IN cord-302530-pp6bl941 71 51 the the DT cord-302530-pp6bl941 71 52 lines line NNS cord-302530-pp6bl941 71 53 in in IN cord-302530-pp6bl941 71 54 Fig Fig NNP cord-302530-pp6bl941 71 55 . . . cord-302530-pp6bl941 72 1 1 1 CD cord-302530-pp6bl941 72 2 and and CC cord-302530-pp6bl941 72 3 typically typically RB cord-302530-pp6bl941 72 4 ranges range VBZ cord-302530-pp6bl941 72 5 from~0 from~0 NNP cord-302530-pp6bl941 72 6 kJ kJ NNP cord-302530-pp6bl941 72 7 / / SYM cord-302530-pp6bl941 72 8 mol mol NNP cord-302530-pp6bl941 72 9 / / SYM cord-302530-pp6bl941 72 10 K K NNP cord-302530-pp6bl941 72 11 to to IN cord-302530-pp6bl941 72 12 −5.0 −5.0 NN cord-302530-pp6bl941 72 13 kJ kJ NNP cord-302530-pp6bl941 72 14 / / SYM cord-302530-pp6bl941 72 15 mol mol NNP cord-302530-pp6bl941 72 16 / / SYM cord-302530-pp6bl941 72 17 K K NNP cord-302530-pp6bl941 72 18 depending depend VBG cord-302530-pp6bl941 72 19 on on IN cord-302530-pp6bl941 72 20 the the DT cord-302530-pp6bl941 72 21 system system NN cord-302530-pp6bl941 72 22 . . . cord-302530-pp6bl941 73 1 The the DT cord-302530-pp6bl941 73 2 previous previous JJ cord-302530-pp6bl941 73 3 thermodynamic thermodynamic JJ cord-302530-pp6bl941 73 4 treatment treatment NN cord-302530-pp6bl941 73 5 of of IN cord-302530-pp6bl941 73 6 virus virus NN cord-302530-pp6bl941 73 7 binding bind VBG cord-302530-pp6bl941 73 8 ( ( -LRB- cord-302530-pp6bl941 73 9 Gale Gale NNP cord-302530-pp6bl941 73 10 2019 2019 CD cord-302530-pp6bl941 73 11 ) ) -RRB- cord-302530-pp6bl941 73 12 identified identify VBD cord-302530-pp6bl941 73 13 the the DT cord-302530-pp6bl941 73 14 entropy entropy NN cord-302530-pp6bl941 73 15 change change NN cord-302530-pp6bl941 73 16 ( ( -LRB- cord-302530-pp6bl941 73 17 ΔS ΔS NNP cord-302530-pp6bl941 73 18 a_immob a_immob NNP cord-302530-pp6bl941 73 19 ) ) -RRB- cord-302530-pp6bl941 73 20 on on IN cord-302530-pp6bl941 73 21 immobilisation immobilisation NN cord-302530-pp6bl941 73 22 of of IN cord-302530-pp6bl941 73 23 the the DT cord-302530-pp6bl941 73 24 whole whole JJ cord-302530-pp6bl941 73 25 virus virus NN cord-302530-pp6bl941 73 26 particle particle NN cord-302530-pp6bl941 73 27 on on IN cord-302530-pp6bl941 73 28 the the DT cord-302530-pp6bl941 73 29 host host NN cord-302530-pp6bl941 73 30 cell cell NN cord-302530-pp6bl941 73 31 surface surface NN cord-302530-pp6bl941 73 32 as as IN cord-302530-pp6bl941 73 33 a a DT cord-302530-pp6bl941 73 34 key key JJ cord-302530-pp6bl941 73 35 parameter parameter NN cord-302530-pp6bl941 73 36 for for IN cord-302530-pp6bl941 73 37 which which WDT cord-302530-pp6bl941 73 38 there there EX cord-302530-pp6bl941 73 39 are be VBP cord-302530-pp6bl941 73 40 currently currently RB cord-302530-pp6bl941 73 41 no no DT cord-302530-pp6bl941 73 42 data data NN cord-302530-pp6bl941 73 43 . . . cord-302530-pp6bl941 74 1 ΔS ΔS NNP cord-302530-pp6bl941 74 2 a_immob a_immob NNP cord-302530-pp6bl941 74 3 would would MD cord-302530-pp6bl941 74 4 be be VB cord-302530-pp6bl941 74 5 expected expect VBN cord-302530-pp6bl941 74 6 to to TO cord-302530-pp6bl941 74 7 be be VB cord-302530-pp6bl941 74 8 large large JJ cord-302530-pp6bl941 74 9 and and CC cord-302530-pp6bl941 74 10 negative negative JJ cord-302530-pp6bl941 74 11 in in IN cord-302530-pp6bl941 74 12 magnitude magnitude NN cord-302530-pp6bl941 74 13 due due IN cord-302530-pp6bl941 74 14 to to IN cord-302530-pp6bl941 74 15 the the DT cord-302530-pp6bl941 74 16 decrease decrease NN cord-302530-pp6bl941 74 17 in in IN cord-302530-pp6bl941 74 18 the the DT cord-302530-pp6bl941 74 19 absolute absolute JJ cord-302530-pp6bl941 74 20 entropy entropy NN cord-302530-pp6bl941 74 21 on on IN cord-302530-pp6bl941 74 22 immobilisation immobilisation NN cord-302530-pp6bl941 74 23 of of IN cord-302530-pp6bl941 74 24 a a DT cord-302530-pp6bl941 74 25 large large JJ cord-302530-pp6bl941 74 26 molecular molecular JJ cord-302530-pp6bl941 74 27 entity entity NN cord-302530-pp6bl941 74 28 such such JJ cord-302530-pp6bl941 74 29 as as IN cord-302530-pp6bl941 74 30 a a DT cord-302530-pp6bl941 74 31 virion virion NN cord-302530-pp6bl941 74 32 . . . cord-302530-pp6bl941 75 1 A a DT cord-302530-pp6bl941 75 2 recent recent JJ cord-302530-pp6bl941 75 3 analysis analysis NN cord-302530-pp6bl941 75 4 has have VBZ cord-302530-pp6bl941 75 5 shown show VBN cord-302530-pp6bl941 75 6 that that IN cord-302530-pp6bl941 75 7 virion virion NN cord-302530-pp6bl941 75 8 volume volume NN cord-302530-pp6bl941 75 9 ( ( -LRB- cord-302530-pp6bl941 75 10 and and CC cord-302530-pp6bl941 75 11 genome genome NN cord-302530-pp6bl941 75 12 length length NN cord-302530-pp6bl941 75 13 ) ) -RRB- cord-302530-pp6bl941 75 14 for for IN cord-302530-pp6bl941 75 15 dsDNA dsdna JJ cord-302530-pp6bl941 75 16 viruses virus NNS cord-302530-pp6bl941 75 17 decreases decrease VBZ cord-302530-pp6bl941 75 18 by by IN cord-302530-pp6bl941 75 19 about about RB cord-302530-pp6bl941 75 20 55-fold 55-fold CD cord-302530-pp6bl941 75 21 as as IN cord-302530-pp6bl941 75 22 the the DT cord-302530-pp6bl941 75 23 temperature temperature NN cord-302530-pp6bl941 75 24 of of IN cord-302530-pp6bl941 75 25 occurrence occurrence NN cord-302530-pp6bl941 75 26 ( ( -LRB- cord-302530-pp6bl941 75 27 i.e. i.e. FW cord-302530-pp6bl941 75 28 host host NN cord-302530-pp6bl941 75 29 ) ) -RRB- cord-302530-pp6bl941 75 30 increases increase NNS cord-302530-pp6bl941 75 31 from from IN cord-302530-pp6bl941 75 32 0 0 CD cord-302530-pp6bl941 75 33 to to IN cord-302530-pp6bl941 75 34 40 40 CD cord-302530-pp6bl941 75 35 ° ° NN cord-302530-pp6bl941 75 36 C c NN cord-302530-pp6bl941 75 37 ( ( -LRB- cord-302530-pp6bl941 75 38 Nifong Nifong NNP cord-302530-pp6bl941 75 39 and and CC cord-302530-pp6bl941 75 40 Gillooly Gillooly NNP cord-302530-pp6bl941 75 41 2016 2016 CD cord-302530-pp6bl941 75 42 ) ) -RRB- cord-302530-pp6bl941 75 43 . . . cord-302530-pp6bl941 76 1 The the DT cord-302530-pp6bl941 76 2 temperature temperature NN cord-302530-pp6bl941 76 3 of of IN cord-302530-pp6bl941 76 4 occurrence occurrence NN cord-302530-pp6bl941 76 5 in in IN cord-302530-pp6bl941 76 6 these these DT cord-302530-pp6bl941 76 7 dsDNA dsdna JJ cord-302530-pp6bl941 76 8 viruses virus NNS cord-302530-pp6bl941 76 9 ranges range VBZ cord-302530-pp6bl941 76 10 from from IN cord-302530-pp6bl941 76 11 near near IN cord-302530-pp6bl941 76 12 zero zero CD cord-302530-pp6bl941 76 13 for for IN cord-302530-pp6bl941 76 14 those those DT cord-302530-pp6bl941 76 15 inhabiting inhabit VBG cord-302530-pp6bl941 76 16 polar polar JJ cord-302530-pp6bl941 76 17 environments environment NNS cord-302530-pp6bl941 76 18 to to IN cord-302530-pp6bl941 76 19 over over IN cord-302530-pp6bl941 76 20 40 40 CD cord-302530-pp6bl941 76 21 ° ° NN cord-302530-pp6bl941 76 22 C c NN cord-302530-pp6bl941 76 23 for for IN cord-302530-pp6bl941 76 24 those those DT cord-302530-pp6bl941 76 25 inhabiting inhabit VBG cord-302530-pp6bl941 76 26 endothermic endothermic JJ cord-302530-pp6bl941 76 27 vertebrates vertebrate NNS cord-302530-pp6bl941 76 28 . . . cord-302530-pp6bl941 77 1 Nifong Nifong NNP cord-302530-pp6bl941 77 2 and and CC cord-302530-pp6bl941 77 3 Gillooly Gillooly NNP cord-302530-pp6bl941 77 4 ( ( -LRB- cord-302530-pp6bl941 77 5 2016 2016 CD cord-302530-pp6bl941 77 6 ) ) -RRB- cord-302530-pp6bl941 77 7 suggest suggest VBP cord-302530-pp6bl941 77 8 that that IN cord-302530-pp6bl941 77 9 this this DT cord-302530-pp6bl941 77 10 could could MD cord-302530-pp6bl941 77 11 reflect reflect VB cord-302530-pp6bl941 77 12 smaller small JJR cord-302530-pp6bl941 77 13 viruses virus NNS cord-302530-pp6bl941 77 14 being be VBG cord-302530-pp6bl941 77 15 able able JJ cord-302530-pp6bl941 77 16 to to TO cord-302530-pp6bl941 77 17 replicate replicate VB cord-302530-pp6bl941 77 18 more more RBR cord-302530-pp6bl941 77 19 quickly quickly RB cord-302530-pp6bl941 77 20 ( ( -LRB- cord-302530-pp6bl941 77 21 due due IN cord-302530-pp6bl941 77 22 to to IN cord-302530-pp6bl941 77 23 more more RBR cord-302530-pp6bl941 77 24 compact compact JJ cord-302530-pp6bl941 77 25 genomes genome NNS cord-302530-pp6bl941 77 26 ) ) -RRB- cord-302530-pp6bl941 77 27 perhaps perhaps RB cord-302530-pp6bl941 77 28 together together RB cord-302530-pp6bl941 77 29 with with IN cord-302530-pp6bl941 77 30 energetic energetic JJ cord-302530-pp6bl941 77 31 constraints constraint NNS cord-302530-pp6bl941 77 32 imposed impose VBN cord-302530-pp6bl941 77 33 by by IN cord-302530-pp6bl941 77 34 their -PRON- PRP$ cord-302530-pp6bl941 77 35 hosts host NNS cord-302530-pp6bl941 77 36 . . . cord-302530-pp6bl941 78 1 However however RB cord-302530-pp6bl941 78 2 from from IN cord-302530-pp6bl941 78 3 the the DT cord-302530-pp6bl941 78 4 thermodynamic thermodynamic JJ cord-302530-pp6bl941 78 5 perspective perspective NN cord-302530-pp6bl941 78 6 , , , cord-302530-pp6bl941 78 7 the the DT cord-302530-pp6bl941 78 8 decrease decrease NN cord-302530-pp6bl941 78 9 in in IN cord-302530-pp6bl941 78 10 volume volume NN cord-302530-pp6bl941 78 11 and and CC cord-302530-pp6bl941 78 12 hence hence RB cord-302530-pp6bl941 78 13 mass mass NN cord-302530-pp6bl941 78 14 and and CC cord-302530-pp6bl941 78 15 radius radius NN cord-302530-pp6bl941 78 16 of of IN cord-302530-pp6bl941 78 17 the the DT cord-302530-pp6bl941 78 18 virus virus NN cord-302530-pp6bl941 78 19 will will MD cord-302530-pp6bl941 78 20 make make VB cord-302530-pp6bl941 78 21 ΔS ΔS NNP cord-302530-pp6bl941 78 22 a_immob a_immob NNP cord-302530-pp6bl941 78 23 less less RBR cord-302530-pp6bl941 78 24 negative negative JJ cord-302530-pp6bl941 78 25 for for IN cord-302530-pp6bl941 78 26 a a DT cord-302530-pp6bl941 78 27 smaller small JJR cord-302530-pp6bl941 78 28 virus virus NN cord-302530-pp6bl941 78 29 than than IN cord-302530-pp6bl941 78 30 for for IN cord-302530-pp6bl941 78 31 a a DT cord-302530-pp6bl941 78 32 larger large JJR cord-302530-pp6bl941 78 33 virus virus NN cord-302530-pp6bl941 78 34 . . . cord-302530-pp6bl941 79 1 It -PRON- PRP cord-302530-pp6bl941 79 2 is be VBZ cord-302530-pp6bl941 79 3 shown show VBN cord-302530-pp6bl941 79 4 here here RB cord-302530-pp6bl941 79 5 how how WRB cord-302530-pp6bl941 79 6 a a DT cord-302530-pp6bl941 79 7 less less RBR cord-302530-pp6bl941 79 8 negative negative JJ cord-302530-pp6bl941 79 9 ΔS ΔS NNP cord-302530-pp6bl941 79 10 a_immob a_immob NNP cord-302530-pp6bl941 79 11 increases increase VBZ cord-302530-pp6bl941 79 12 binding binding NN cord-302530-pp6bl941 79 13 of of IN cord-302530-pp6bl941 79 14 the the DT cord-302530-pp6bl941 79 15 virus virus NN cord-302530-pp6bl941 79 16 at at IN cord-302530-pp6bl941 79 17 the the DT cord-302530-pp6bl941 79 18 relatively relatively RB cord-302530-pp6bl941 79 19 high high JJ cord-302530-pp6bl941 79 20 mammalian mammalian JJ cord-302530-pp6bl941 79 21 body body NN cord-302530-pp6bl941 79 22 temperatures temperature NNS cord-302530-pp6bl941 79 23 and and CC cord-302530-pp6bl941 79 24 it -PRON- PRP cord-302530-pp6bl941 79 25 is be VBZ cord-302530-pp6bl941 79 26 proposed propose VBN cord-302530-pp6bl941 79 27 that that IN cord-302530-pp6bl941 79 28 thermodynamic thermodynamic JJ cord-302530-pp6bl941 79 29 binding binding NN cord-302530-pp6bl941 79 30 constraints constraint NNS cord-302530-pp6bl941 79 31 may may MD cord-302530-pp6bl941 79 32 give give VB cord-302530-pp6bl941 79 33 smaller small JJR cord-302530-pp6bl941 79 34 viruses virus NNS cord-302530-pp6bl941 79 35 a a DT cord-302530-pp6bl941 79 36 selective selective JJ cord-302530-pp6bl941 79 37 advantage advantage NN cord-302530-pp6bl941 79 38 for for IN cord-302530-pp6bl941 79 39 infecting infect VBG cord-302530-pp6bl941 79 40 hosts host NNS cord-302530-pp6bl941 79 41 at at IN cord-302530-pp6bl941 79 42 the the DT cord-302530-pp6bl941 79 43 higher high JJR cord-302530-pp6bl941 79 44 body body NN cord-302530-pp6bl941 79 45 temperatures temperature NNS cord-302530-pp6bl941 79 46 of of IN cord-302530-pp6bl941 79 47 mammals mammal NNS cord-302530-pp6bl941 79 48 and and CC cord-302530-pp6bl941 79 49 birds bird NNS cord-302530-pp6bl941 79 50 . . . cord-302530-pp6bl941 80 1 In in IN cord-302530-pp6bl941 80 2 this this DT cord-302530-pp6bl941 80 3 respect respect NN cord-302530-pp6bl941 80 4 , , , cord-302530-pp6bl941 80 5 the the DT cord-302530-pp6bl941 80 6 large large JJ cord-302530-pp6bl941 80 7 size size NN cord-302530-pp6bl941 80 8 of of IN cord-302530-pp6bl941 80 9 the the DT cord-302530-pp6bl941 80 10 HIV HIV NNP cord-302530-pp6bl941 80 11 virion virion NN cord-302530-pp6bl941 80 12 may may MD cord-302530-pp6bl941 80 13 present present VB cord-302530-pp6bl941 80 14 a a DT cord-302530-pp6bl941 80 15 constraint constraint NN cord-302530-pp6bl941 80 16 to to IN cord-302530-pp6bl941 80 17 binding bind VBG cord-302530-pp6bl941 80 18 at at IN cord-302530-pp6bl941 80 19 human human JJ cord-302530-pp6bl941 80 20 body body NN cord-302530-pp6bl941 80 21 temperatures temperature NNS cord-302530-pp6bl941 80 22 compared compare VBN cord-302530-pp6bl941 80 23 to to IN cord-302530-pp6bl941 80 24 the the DT cord-302530-pp6bl941 80 25 much much RB cord-302530-pp6bl941 80 26 smaller small JJR cord-302530-pp6bl941 80 27 arboviruses arbovirus NNS cord-302530-pp6bl941 80 28 for for IN cord-302530-pp6bl941 80 29 example example NN cord-302530-pp6bl941 80 30 . . . cord-302530-pp6bl941 81 1 In in IN cord-302530-pp6bl941 81 2 the the DT cord-302530-pp6bl941 81 3 case case NN cord-302530-pp6bl941 81 4 of of IN cord-302530-pp6bl941 81 5 HIV HIV NNP cord-302530-pp6bl941 81 6 , , , cord-302530-pp6bl941 81 7 the the DT cord-302530-pp6bl941 81 8 GP GP NNP cord-302530-pp6bl941 81 9 component component NN cord-302530-pp6bl941 81 10 of of IN cord-302530-pp6bl941 81 11 the the DT cord-302530-pp6bl941 81 12 GP GP NNP cord-302530-pp6bl941 81 13 / / SYM cord-302530-pp6bl941 81 14 Cr cr NN cord-302530-pp6bl941 81 15 interaction interaction NN cord-302530-pp6bl941 81 16 is be VBZ cord-302530-pp6bl941 81 17 the the DT cord-302530-pp6bl941 81 18 envelope envelope NN cord-302530-pp6bl941 81 19 protein protein NN cord-302530-pp6bl941 81 20 ( ( -LRB- cord-302530-pp6bl941 81 21 Env Env NNP cord-302530-pp6bl941 81 22 ) ) -RRB- cord-302530-pp6bl941 81 23 which which WDT cord-302530-pp6bl941 81 24 is be VBZ cord-302530-pp6bl941 81 25 a a DT cord-302530-pp6bl941 81 26 trimer trimer NN cord-302530-pp6bl941 81 27 of of IN cord-302530-pp6bl941 81 28 gp120 gp120 NNP cord-302530-pp6bl941 81 29 monomers monomer NNS cord-302530-pp6bl941 81 30 . . . cord-302530-pp6bl941 82 1 Each each DT cord-302530-pp6bl941 82 2 HIV HIV NNP cord-302530-pp6bl941 82 3 Fig Fig NNP cord-302530-pp6bl941 82 4 . . . cord-302530-pp6bl941 83 1 1 1 LS cord-302530-pp6bl941 83 2 . . . cord-302530-pp6bl941 84 1 Variation variation NN cord-302530-pp6bl941 84 2 in in IN cord-302530-pp6bl941 84 3 ΔH ΔH NNP cord-302530-pp6bl941 84 4 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 84 5 as as IN cord-302530-pp6bl941 84 6 a a DT cord-302530-pp6bl941 84 7 function function NN cord-302530-pp6bl941 84 8 of of IN cord-302530-pp6bl941 84 9 temperature temperature NN cord-302530-pp6bl941 84 10 as as IN cord-302530-pp6bl941 84 11 reported report VBN cord-302530-pp6bl941 84 12 for for IN cord-302530-pp6bl941 84 13 HIV HIV NNP cord-302530-pp6bl941 85 1 gp120 gp120 NNP cord-302530-pp6bl941 85 2 monomer monomer NN cord-302530-pp6bl941 85 3 binding bind VBG cord-302530-pp6bl941 85 4 to to IN cord-302530-pp6bl941 85 5 CD4 CD4 NNP cord-302530-pp6bl941 85 6 ( ( -LRB- cord-302530-pp6bl941 85 7 ○ ○ NNP cord-302530-pp6bl941 85 8 ) ) -RRB- cord-302530-pp6bl941 86 1 ( ( -LRB- cord-302530-pp6bl941 86 2 Myszka Myszka NNP cord-302530-pp6bl941 86 3 et et NNP cord-302530-pp6bl941 86 4 al al NNP cord-302530-pp6bl941 86 5 . . NNP cord-302530-pp6bl941 86 6 , , , cord-302530-pp6bl941 86 7 2000 2000 CD cord-302530-pp6bl941 86 8 ) ) -RRB- cord-302530-pp6bl941 86 9 and and CC cord-302530-pp6bl941 86 10 AIV AIV NNP cord-302530-pp6bl941 86 11 HA HA NNP cord-302530-pp6bl941 86 12 monomer monomer NN cord-302530-pp6bl941 86 13 binding bind VBG cord-302530-pp6bl941 86 14 to to IN cord-302530-pp6bl941 86 15 soluble soluble JJ cord-302530-pp6bl941 86 16 α2 α2 NNP cord-302530-pp6bl941 86 17 - - HYPH cord-302530-pp6bl941 86 18 6 6 CD cord-302530-pp6bl941 86 19 sialyllactose sialyllactose NN cord-302530-pp6bl941 86 20 ( ( -LRB- cord-302530-pp6bl941 86 21 Δ δ NN cord-302530-pp6bl941 86 22 ) ) -RRB- cord-302530-pp6bl941 86 23 and and CC cord-302530-pp6bl941 86 24 α2 α2 NN cord-302530-pp6bl941 86 25 - - HYPH cord-302530-pp6bl941 86 26 3 3 CD cord-302530-pp6bl941 86 27 sialyllactose sialyllactose NN cord-302530-pp6bl941 86 28 ( ( -LRB- cord-302530-pp6bl941 86 29 □ □ NFP cord-302530-pp6bl941 86 30 ) ) -RRB- cord-302530-pp6bl941 87 1 ( ( -LRB- cord-302530-pp6bl941 87 2 Fei Fei NNP cord-302530-pp6bl941 87 3 et et NNP cord-302530-pp6bl941 87 4 al al NNP cord-302530-pp6bl941 87 5 . . NNP cord-302530-pp6bl941 87 6 , , , cord-302530-pp6bl941 87 7 2015 2015 CD cord-302530-pp6bl941 87 8 ) ) -RRB- cord-302530-pp6bl941 87 9 . . . cord-302530-pp6bl941 88 1 The the DT cord-302530-pp6bl941 88 2 slopes slope NNS cord-302530-pp6bl941 88 3 of of IN cord-302530-pp6bl941 88 4 the the DT cord-302530-pp6bl941 88 5 lines line NNS cord-302530-pp6bl941 88 6 represent represent VBP cord-302530-pp6bl941 88 7 the the DT cord-302530-pp6bl941 88 8 ΔC ΔC NNP cord-302530-pp6bl941 88 9 p p NN cord-302530-pp6bl941 88 10 values value NNS cord-302530-pp6bl941 88 11 which which WDT cord-302530-pp6bl941 88 12 are be VBP cord-302530-pp6bl941 88 13 summarised summarise VBN cord-302530-pp6bl941 88 14 in in IN cord-302530-pp6bl941 88 15 Table Table NNP cord-302530-pp6bl941 88 16 3 3 CD cord-302530-pp6bl941 88 17 . . . cord-302530-pp6bl941 89 1 Env Env NNP cord-302530-pp6bl941 89 2 trimer trimer NN cord-302530-pp6bl941 89 3 interacts interact VBZ cord-302530-pp6bl941 89 4 with with IN cord-302530-pp6bl941 89 5 one one CD cord-302530-pp6bl941 89 6 CD4 CD4 NNP cord-302530-pp6bl941 89 7 molecule molecule NN cord-302530-pp6bl941 89 8 ( ( -LRB- cord-302530-pp6bl941 89 9 Chuang Chuang NNP cord-302530-pp6bl941 89 10 et et NNP cord-302530-pp6bl941 89 11 al al NNP cord-302530-pp6bl941 89 12 . . NNP cord-302530-pp6bl941 89 13 , , , cord-302530-pp6bl941 89 14 2017 2017 CD cord-302530-pp6bl941 89 15 ; ; : cord-302530-pp6bl941 89 16 Liu Liu NNP cord-302530-pp6bl941 89 17 et et NNP cord-302530-pp6bl941 89 18 al al NNP cord-302530-pp6bl941 89 19 . . NNP cord-302530-pp6bl941 89 20 , , , cord-302530-pp6bl941 89 21 2017a 2017a CD cord-302530-pp6bl941 89 22 ) ) -RRB- cord-302530-pp6bl941 89 23 . . . cord-302530-pp6bl941 90 1 This this DT cord-302530-pp6bl941 90 2 is be VBZ cord-302530-pp6bl941 90 3 different different JJ cord-302530-pp6bl941 90 4 from from IN cord-302530-pp6bl941 90 5 the the DT cord-302530-pp6bl941 90 6 AIV AIV NNP cord-302530-pp6bl941 90 7 HA HA NNP cord-302530-pp6bl941 90 8 trimer trimer NN cord-302530-pp6bl941 90 9 in in IN cord-302530-pp6bl941 90 10 which which WDT cord-302530-pp6bl941 90 11 each each DT cord-302530-pp6bl941 90 12 monomer monomer NN cord-302530-pp6bl941 90 13 in in IN cord-302530-pp6bl941 90 14 the the DT cord-302530-pp6bl941 90 15 trimer trimer NN cord-302530-pp6bl941 90 16 interacts interact VBZ cord-302530-pp6bl941 90 17 with with IN cord-302530-pp6bl941 90 18 one one CD cord-302530-pp6bl941 90 19 glycan glycan NN cord-302530-pp6bl941 90 20 Cr cr NN cord-302530-pp6bl941 90 21 ( ( -LRB- cord-302530-pp6bl941 90 22 De De NNP cord-302530-pp6bl941 90 23 Graaf Graaf NNP cord-302530-pp6bl941 90 24 and and CC cord-302530-pp6bl941 90 25 Fouchier Fouchier NNP cord-302530-pp6bl941 90 26 , , , cord-302530-pp6bl941 90 27 2014 2014 CD cord-302530-pp6bl941 90 28 ; ; . cord-302530-pp6bl941 91 1 Fei Fei NNP cord-302530-pp6bl941 91 2 et et NNP cord-302530-pp6bl941 91 3 al al NNP cord-302530-pp6bl941 91 4 . . NNP cord-302530-pp6bl941 91 5 , , , cord-302530-pp6bl941 91 6 2015 2015 CD cord-302530-pp6bl941 91 7 ) ) -RRB- cord-302530-pp6bl941 91 8 . . . cord-302530-pp6bl941 92 1 Initial initial JJ cord-302530-pp6bl941 92 2 attachment attachment NN cord-302530-pp6bl941 92 3 of of IN cord-302530-pp6bl941 92 4 the the DT cord-302530-pp6bl941 92 5 HIV HIV NNP cord-302530-pp6bl941 92 6 virion virion NN cord-302530-pp6bl941 92 7 to to IN cord-302530-pp6bl941 92 8 the the DT cord-302530-pp6bl941 92 9 host host NN cord-302530-pp6bl941 92 10 CD4 CD4 NNP cord-302530-pp6bl941 92 11 + + CC cord-302530-pp6bl941 92 12 T T NNP cord-302530-pp6bl941 92 13 cell cell NN cord-302530-pp6bl941 92 14 surface surface NN cord-302530-pp6bl941 92 15 is be VBZ cord-302530-pp6bl941 92 16 relatively relatively RB cord-302530-pp6bl941 92 17 nonspecific nonspecific JJ cord-302530-pp6bl941 92 18 ( ( -LRB- cord-302530-pp6bl941 92 19 Wilen Wilen NNP cord-302530-pp6bl941 92 20 et et NNP cord-302530-pp6bl941 92 21 al al NNP cord-302530-pp6bl941 92 22 . . NNP cord-302530-pp6bl941 92 23 , , , cord-302530-pp6bl941 92 24 2012 2012 CD cord-302530-pp6bl941 92 25 ) ) -RRB- cord-302530-pp6bl941 92 26 with with IN cord-302530-pp6bl941 92 27 HIV HIV NNP cord-302530-pp6bl941 92 28 Env Env NNP cord-302530-pp6bl941 92 29 interacting interact VBG cord-302530-pp6bl941 92 30 with with IN cord-302530-pp6bl941 92 31 negatively negatively RB cord-302530-pp6bl941 92 32 charged charge VBN cord-302530-pp6bl941 92 33 host host NN cord-302530-pp6bl941 92 34 cell cell NN cord-302530-pp6bl941 92 35 surface surface NN cord-302530-pp6bl941 92 36 heparan heparan NN cord-302530-pp6bl941 92 37 sulphate sulphate NN cord-302530-pp6bl941 92 38 proteoglycans proteoglycan NNS cord-302530-pp6bl941 92 39 , , , cord-302530-pp6bl941 92 40 or or CC cord-302530-pp6bl941 92 41 with with IN cord-302530-pp6bl941 92 42 pattern pattern NN cord-302530-pp6bl941 92 43 recognition recognition NN cord-302530-pp6bl941 92 44 receptors receptor NNS cord-302530-pp6bl941 92 45 . . . cord-302530-pp6bl941 93 1 According accord VBG cord-302530-pp6bl941 93 2 to to IN cord-302530-pp6bl941 93 3 Wilen Wilen NNP cord-302530-pp6bl941 93 4 et et NNP cord-302530-pp6bl941 93 5 al al NNP cord-302530-pp6bl941 93 6 . . . cord-302530-pp6bl941 94 1 ( ( -LRB- cord-302530-pp6bl941 94 2 2012 2012 CD cord-302530-pp6bl941 94 3 ) ) -RRB- cord-302530-pp6bl941 94 4 , , , cord-302530-pp6bl941 94 5 non non JJ cord-302530-pp6bl941 94 6 - - JJ cord-302530-pp6bl941 94 7 specific specific JJ cord-302530-pp6bl941 94 8 HIV HIV NNP cord-302530-pp6bl941 94 9 attachment attachment NN cord-302530-pp6bl941 94 10 to to IN cord-302530-pp6bl941 94 11 the the DT cord-302530-pp6bl941 94 12 host host NN cord-302530-pp6bl941 94 13 cell cell NN cord-302530-pp6bl941 94 14 via via IN cord-302530-pp6bl941 94 15 any any DT cord-302530-pp6bl941 94 16 of of IN cord-302530-pp6bl941 94 17 these these DT cord-302530-pp6bl941 94 18 factors factor NNS cord-302530-pp6bl941 94 19 likely likely RB cord-302530-pp6bl941 94 20 brings bring VBZ cord-302530-pp6bl941 94 21 HIV HIV NNP cord-302530-pp6bl941 94 22 Env Env NNP cord-302530-pp6bl941 94 23 into into IN cord-302530-pp6bl941 94 24 close close JJ cord-302530-pp6bl941 94 25 proximity proximity NN cord-302530-pp6bl941 94 26 with with IN cord-302530-pp6bl941 94 27 the the DT cord-302530-pp6bl941 94 28 viral viral JJ cord-302530-pp6bl941 94 29 receptor receptor NN cord-302530-pp6bl941 94 30 CD4 CD4 NNP cord-302530-pp6bl941 94 31 and and CC cord-302530-pp6bl941 94 32 the the DT cord-302530-pp6bl941 94 33 CRR5 CRR5 NNP cord-302530-pp6bl941 94 34 coreceptor coreceptor NN cord-302530-pp6bl941 94 35 , , , cord-302530-pp6bl941 94 36 so so CC cord-302530-pp6bl941 94 37 increasing increase VBG cord-302530-pp6bl941 94 38 the the DT cord-302530-pp6bl941 94 39 efficiency efficiency NN cord-302530-pp6bl941 94 40 of of IN cord-302530-pp6bl941 94 41 infection infection NN cord-302530-pp6bl941 94 42 , , , cord-302530-pp6bl941 94 43 although although IN cord-302530-pp6bl941 94 44 the the DT cord-302530-pp6bl941 94 45 physiologic physiologic JJ cord-302530-pp6bl941 94 46 role role NN cord-302530-pp6bl941 94 47 of of IN cord-302530-pp6bl941 94 48 non non JJ cord-302530-pp6bl941 94 49 - - JJ cord-302530-pp6bl941 94 50 specific specific JJ cord-302530-pp6bl941 94 51 attachment attachment NN cord-302530-pp6bl941 94 52 in in IN cord-302530-pp6bl941 94 53 vivo vivo NNP cord-302530-pp6bl941 94 54 remains remain VBZ cord-302530-pp6bl941 94 55 unclear unclear JJ cord-302530-pp6bl941 94 56 . . . cord-302530-pp6bl941 95 1 Here here RB cord-302530-pp6bl941 95 2 it -PRON- PRP cord-302530-pp6bl941 95 3 is be VBZ cord-302530-pp6bl941 95 4 suggested suggest VBN cord-302530-pp6bl941 95 5 that that IN cord-302530-pp6bl941 95 6 non non JJ cord-302530-pp6bl941 95 7 - - JJ cord-302530-pp6bl941 95 8 specific specific JJ cord-302530-pp6bl941 95 9 binding binding NN cord-302530-pp6bl941 95 10 helps help VBZ cord-302530-pp6bl941 95 11 to to TO cord-302530-pp6bl941 95 12 overcome overcome VB cord-302530-pp6bl941 95 13 the the DT cord-302530-pp6bl941 95 14 thermodynamic thermodynamic JJ cord-302530-pp6bl941 95 15 entropy entropy NN cord-302530-pp6bl941 95 16 constraint constraint NN cord-302530-pp6bl941 95 17 of of IN cord-302530-pp6bl941 95 18 immobilisation immobilisation NN cord-302530-pp6bl941 95 19 of of IN cord-302530-pp6bl941 95 20 a a DT cord-302530-pp6bl941 95 21 large large JJ cord-302530-pp6bl941 95 22 virus virus NN cord-302530-pp6bl941 95 23 on on IN cord-302530-pp6bl941 95 24 binding bind VBG cord-302530-pp6bl941 95 25 at at IN cord-302530-pp6bl941 95 26 human human JJ cord-302530-pp6bl941 95 27 body body NN cord-302530-pp6bl941 95 28 temperature temperature NN cord-302530-pp6bl941 95 29 by by IN cord-302530-pp6bl941 95 30 taking take VBG cord-302530-pp6bl941 95 31 some some DT cord-302530-pp6bl941 95 32 of of IN cord-302530-pp6bl941 95 33 the the DT cord-302530-pp6bl941 95 34 entropy entropy NN cord-302530-pp6bl941 95 35 loss loss NN cord-302530-pp6bl941 95 36 in in IN cord-302530-pp6bl941 95 37 ΔS ΔS NNP cord-302530-pp6bl941 95 38 a_immob a_immob NNP cord-302530-pp6bl941 95 39 prior prior RB cord-302530-pp6bl941 95 40 to to IN cord-302530-pp6bl941 95 41 specific specific JJ cord-302530-pp6bl941 95 42 HIV HIV NNP cord-302530-pp6bl941 95 43 Env Env NNP cord-302530-pp6bl941 95 44 : : : cord-302530-pp6bl941 96 1 CD4 CD4 NNP cord-302530-pp6bl941 96 2 binding bind VBG cord-302530-pp6bl941 96 3 . . . cord-302530-pp6bl941 97 1 This this DT cord-302530-pp6bl941 97 2 would would MD cord-302530-pp6bl941 97 3 be be VB cord-302530-pp6bl941 97 4 consistent consistent JJ cord-302530-pp6bl941 97 5 with with IN cord-302530-pp6bl941 97 6 the the DT cord-302530-pp6bl941 97 7 fact fact NN cord-302530-pp6bl941 97 8 that that IN cord-302530-pp6bl941 97 9 non non JJ cord-302530-pp6bl941 97 10 - - JJ cord-302530-pp6bl941 97 11 specific specific JJ cord-302530-pp6bl941 97 12 attachment attachment NN cord-302530-pp6bl941 97 13 factors factor NNS cord-302530-pp6bl941 97 14 differ differ VBP cord-302530-pp6bl941 97 15 from from IN cord-302530-pp6bl941 97 16 receptors receptor NNS cord-302530-pp6bl941 97 17 in in IN cord-302530-pp6bl941 97 18 that that IN cord-302530-pp6bl941 97 19 they -PRON- PRP cord-302530-pp6bl941 97 20 are be VBP cord-302530-pp6bl941 97 21 not not RB cord-302530-pp6bl941 97 22 essential essential JJ cord-302530-pp6bl941 97 23 , , , cord-302530-pp6bl941 97 24 although although IN cord-302530-pp6bl941 97 25 they -PRON- PRP cord-302530-pp6bl941 97 26 augment augment VBP cord-302530-pp6bl941 97 27 infection infection NN cord-302530-pp6bl941 97 28 in in IN cord-302530-pp6bl941 97 29 vitro vitro FW cord-302530-pp6bl941 98 1 ( ( -LRB- cord-302530-pp6bl941 98 2 Wilen Wilen NNP cord-302530-pp6bl941 98 3 et et NNP cord-302530-pp6bl941 98 4 al al NNP cord-302530-pp6bl941 98 5 . . NNP cord-302530-pp6bl941 98 6 , , , cord-302530-pp6bl941 98 7 2012 2012 CD cord-302530-pp6bl941 98 8 ) ) -RRB- cord-302530-pp6bl941 98 9 . . . cord-302530-pp6bl941 99 1 A a DT cord-302530-pp6bl941 99 2 review review NN cord-302530-pp6bl941 99 3 of of IN cord-302530-pp6bl941 99 4 the the DT cord-302530-pp6bl941 99 5 literature literature NN cord-302530-pp6bl941 99 6 has have VBZ cord-302530-pp6bl941 99 7 not not RB cord-302530-pp6bl941 99 8 found find VBN cord-302530-pp6bl941 99 9 any any DT cord-302530-pp6bl941 99 10 results result NNS cord-302530-pp6bl941 99 11 for for IN cord-302530-pp6bl941 99 12 the the DT cord-302530-pp6bl941 99 13 effect effect NN cord-302530-pp6bl941 99 14 of of IN cord-302530-pp6bl941 99 15 temperature temperature NN cord-302530-pp6bl941 99 16 on on IN cord-302530-pp6bl941 99 17 the the DT cord-302530-pp6bl941 99 18 binding binding NN cord-302530-pp6bl941 99 19 of of IN cord-302530-pp6bl941 99 20 HIV HIV NNP cord-302530-pp6bl941 99 21 to to IN cord-302530-pp6bl941 99 22 CD4 CD4 NNP cord-302530-pp6bl941 99 23 + + CC cord-302530-pp6bl941 99 24 T t NN cord-302530-pp6bl941 99 25 cells cell NNS cord-302530-pp6bl941 99 26 with with IN cord-302530-pp6bl941 99 27 which which WDT cord-302530-pp6bl941 99 28 to to TO cord-302530-pp6bl941 99 29 test test VB cord-302530-pp6bl941 99 30 or or CC cord-302530-pp6bl941 99 31 validate validate VB cord-302530-pp6bl941 99 32 the the DT cord-302530-pp6bl941 99 33 HIV HIV NNP cord-302530-pp6bl941 99 34 thermodynamic thermodynamic JJ cord-302530-pp6bl941 99 35 binding binding NN cord-302530-pp6bl941 99 36 model model NN cord-302530-pp6bl941 99 37 developed develop VBN cord-302530-pp6bl941 99 38 here here RB cord-302530-pp6bl941 99 39 . . . cord-302530-pp6bl941 100 1 However however RB cord-302530-pp6bl941 100 2 , , , cord-302530-pp6bl941 100 3 Frey Frey NNP cord-302530-pp6bl941 100 4 et et NNP cord-302530-pp6bl941 100 5 al al NNP cord-302530-pp6bl941 100 6 . . . cord-302530-pp6bl941 101 1 ( ( -LRB- cord-302530-pp6bl941 101 2 1995 1995 CD cord-302530-pp6bl941 101 3 ) ) -RRB- cord-302530-pp6bl941 101 4 reported report VBD cord-302530-pp6bl941 101 5 the the DT cord-302530-pp6bl941 101 6 binding binding NN cord-302530-pp6bl941 101 7 of of IN cord-302530-pp6bl941 101 8 cells cell NNS cord-302530-pp6bl941 101 9 expressing express VBG cord-302530-pp6bl941 101 10 HIV HIV NNP cord-302530-pp6bl941 101 11 GP GP NNP cord-302530-pp6bl941 101 12 on on IN cord-302530-pp6bl941 101 13 their -PRON- PRP$ cord-302530-pp6bl941 101 14 surface surface NN cord-302530-pp6bl941 101 15 to to IN cord-302530-pp6bl941 101 16 CD4 CD4 NNP cord-302530-pp6bl941 101 17 + + CC cord-302530-pp6bl941 101 18 T t NN cord-302530-pp6bl941 101 19 cells cell NNS cord-302530-pp6bl941 101 20 over over IN cord-302530-pp6bl941 101 21 the the DT cord-302530-pp6bl941 101 22 temperature temperature NN cord-302530-pp6bl941 101 23 range range NN cord-302530-pp6bl941 101 24 of of IN cord-302530-pp6bl941 101 25 0 0 CD cord-302530-pp6bl941 101 26 ° ° NN cord-302530-pp6bl941 101 27 C c NN cord-302530-pp6bl941 101 28 to to IN cord-302530-pp6bl941 101 29 42 42 CD cord-302530-pp6bl941 101 30 ° ° NN cord-302530-pp6bl941 101 31 C c NN cord-302530-pp6bl941 101 32 . . . cord-302530-pp6bl941 102 1 It -PRON- PRP cord-302530-pp6bl941 102 2 is be VBZ cord-302530-pp6bl941 102 3 known know VBN cord-302530-pp6bl941 102 4 that that IN cord-302530-pp6bl941 102 5 increasing increase VBG cord-302530-pp6bl941 102 6 host host NN cord-302530-pp6bl941 102 7 membrane membrane NN cord-302530-pp6bl941 102 8 fluidity fluidity NN cord-302530-pp6bl941 102 9 at at IN cord-302530-pp6bl941 102 10 higher high JJR cord-302530-pp6bl941 102 11 temperature temperature NN cord-302530-pp6bl941 102 12 allows allow VBZ cord-302530-pp6bl941 102 13 effective effective JJ cord-302530-pp6bl941 102 14 recruitment recruitment NN cord-302530-pp6bl941 102 15 of of IN cord-302530-pp6bl941 102 16 more more JJR cord-302530-pp6bl941 102 17 Cr cr NN cord-302530-pp6bl941 102 18 molecules molecule NNS cord-302530-pp6bl941 102 19 to to TO cord-302530-pp6bl941 102 20 bind bind VB cord-302530-pp6bl941 102 21 the the DT cord-302530-pp6bl941 102 22 HIV HIV NNP cord-302530-pp6bl941 102 23 virion virion NN cord-302530-pp6bl941 102 24 ( ( -LRB- cord-302530-pp6bl941 102 25 Harada Harada NNP cord-302530-pp6bl941 102 26 et et NNP cord-302530-pp6bl941 102 27 al al NNP cord-302530-pp6bl941 102 28 . . NNP cord-302530-pp6bl941 102 29 , , , cord-302530-pp6bl941 102 30 2004 2004 CD cord-302530-pp6bl941 102 31 ) ) -RRB- cord-302530-pp6bl941 103 1 such such JJ cord-302530-pp6bl941 103 2 that that IN cord-302530-pp6bl941 103 3 the the DT cord-302530-pp6bl941 103 4 number number NN cord-302530-pp6bl941 103 5 , , , cord-302530-pp6bl941 103 6 n n NN cord-302530-pp6bl941 103 7 , , , cord-302530-pp6bl941 103 8 of of IN cord-302530-pp6bl941 103 9 GP GP NNP cord-302530-pp6bl941 103 10 / / SYM cord-302530-pp6bl941 103 11 Cr cr NN cord-302530-pp6bl941 103 12 contacts contact NNS cord-302530-pp6bl941 103 13 increases increase VBZ cord-302530-pp6bl941 103 14 with with IN cord-302530-pp6bl941 103 15 temperature temperature NN cord-302530-pp6bl941 104 1 ( ( -LRB- cord-302530-pp6bl941 104 2 Frey Frey NNP cord-302530-pp6bl941 104 3 et et NNP cord-302530-pp6bl941 104 4 al al NNP cord-302530-pp6bl941 104 5 . . NNP cord-302530-pp6bl941 104 6 , , , cord-302530-pp6bl941 104 7 1995 1995 CD cord-302530-pp6bl941 104 8 ) ) -RRB- cord-302530-pp6bl941 104 9 , , . cord-302530-pp6bl941 105 1 and and CC cord-302530-pp6bl941 105 2 that that IN cord-302530-pp6bl941 105 3 increasing increase VBG cord-302530-pp6bl941 105 4 n n NN cord-302530-pp6bl941 105 5 can can MD cord-302530-pp6bl941 105 6 overcome overcome VB cord-302530-pp6bl941 105 7 both both CC cord-302530-pp6bl941 105 8 the the DT cord-302530-pp6bl941 105 9 effect effect NN cord-302530-pp6bl941 105 10 of of IN cord-302530-pp6bl941 105 11 temperature temperature NN cord-302530-pp6bl941 105 12 on on IN cord-302530-pp6bl941 105 13 decreasing decrease VBG cord-302530-pp6bl941 105 14 the the DT cord-302530-pp6bl941 105 15 GP GP NNP cord-302530-pp6bl941 105 16 / / SYM cord-302530-pp6bl941 105 17 Cr cr NN cord-302530-pp6bl941 105 18 binding bind VBG cord-302530-pp6bl941 105 19 affinity affinity NN cord-302530-pp6bl941 105 20 and and CC cord-302530-pp6bl941 105 21 the the DT cord-302530-pp6bl941 105 22 effect effect NN cord-302530-pp6bl941 105 23 of of IN cord-302530-pp6bl941 105 24 a a DT cord-302530-pp6bl941 105 25 large large JJ cord-302530-pp6bl941 105 26 negative negative JJ cord-302530-pp6bl941 105 27 ΔS ΔS NNP cord-302530-pp6bl941 105 28 a_immob a_immob NNP cord-302530-pp6bl941 105 29 ( ( -LRB- cord-302530-pp6bl941 105 30 Gale Gale NNP cord-302530-pp6bl941 105 31 2019 2019 CD cord-302530-pp6bl941 105 32 ) ) -RRB- cord-302530-pp6bl941 105 33 . . . cord-302530-pp6bl941 106 1 The the DT cord-302530-pp6bl941 106 2 thermodynamic thermodynamic JJ cord-302530-pp6bl941 106 3 HIV HIV NNP cord-302530-pp6bl941 106 4 binding binding NN cord-302530-pp6bl941 106 5 model model NN cord-302530-pp6bl941 106 6 here here RB cord-302530-pp6bl941 106 7 is be VBZ cord-302530-pp6bl941 106 8 therefore therefore RB cord-302530-pp6bl941 106 9 modified modify VBN cord-302530-pp6bl941 106 10 to to TO cord-302530-pp6bl941 106 11 accommodate accommodate VB cord-302530-pp6bl941 106 12 increasing increase VBG cord-302530-pp6bl941 106 13 n n NN cord-302530-pp6bl941 106 14 with with IN cord-302530-pp6bl941 106 15 temperature temperature NN cord-302530-pp6bl941 106 16 and and CC cord-302530-pp6bl941 106 17 so so RB cord-302530-pp6bl941 106 18 attempt attempt VB cord-302530-pp6bl941 106 19 to to TO cord-302530-pp6bl941 106 20 reproduce reproduce VB cord-302530-pp6bl941 106 21 the the DT cord-302530-pp6bl941 106 22 results result NNS cord-302530-pp6bl941 106 23 of of IN cord-302530-pp6bl941 106 24 Frey Frey NNP cord-302530-pp6bl941 106 25 et et NNP cord-302530-pp6bl941 106 26 al al NNP cord-302530-pp6bl941 106 27 . . . cord-302530-pp6bl941 107 1 ( ( -LRB- cord-302530-pp6bl941 107 2 1995 1995 CD cord-302530-pp6bl941 107 3 ) ) -RRB- cord-302530-pp6bl941 107 4 . . . cord-302530-pp6bl941 108 1 The the DT cord-302530-pp6bl941 108 2 success success NN cord-302530-pp6bl941 108 3 of of IN cord-302530-pp6bl941 108 4 the the DT cord-302530-pp6bl941 108 5 model model NN cord-302530-pp6bl941 108 6 here here RB cord-302530-pp6bl941 108 7 is be VBZ cord-302530-pp6bl941 108 8 in in IN cord-302530-pp6bl941 108 9 predicting predict VBG cord-302530-pp6bl941 108 10 the the DT cord-302530-pp6bl941 108 11 subsequent subsequent JJ cord-302530-pp6bl941 108 12 decrease decrease NN cord-302530-pp6bl941 108 13 in in IN cord-302530-pp6bl941 108 14 binding bind VBG cord-302530-pp6bl941 108 15 reported report VBN cord-302530-pp6bl941 108 16 by by IN cord-302530-pp6bl941 108 17 Frey Frey NNP cord-302530-pp6bl941 108 18 et et NNP cord-302530-pp6bl941 108 19 al al NNP cord-302530-pp6bl941 108 20 . . . cord-302530-pp6bl941 109 1 ( ( -LRB- cord-302530-pp6bl941 109 2 1995 1995 CD cord-302530-pp6bl941 109 3 ) ) -RRB- cord-302530-pp6bl941 109 4 at at IN cord-302530-pp6bl941 109 5 higher high JJR cord-302530-pp6bl941 109 6 temperatures temperature NNS cord-302530-pp6bl941 109 7 due due JJ cord-302530-pp6bl941 109 8 to to IN cord-302530-pp6bl941 109 9 ΔS ΔS NNP cord-302530-pp6bl941 109 10 a_immob a_immob NNP cord-302530-pp6bl941 109 11 . . . cord-302530-pp6bl941 110 1 Here here RB cord-302530-pp6bl941 110 2 six six CD cord-302530-pp6bl941 110 3 case case NN cord-302530-pp6bl941 110 4 studies study NNS cord-302530-pp6bl941 110 5 are be VBP cord-302530-pp6bl941 110 6 presented present VBN cord-302530-pp6bl941 110 7 to to TO cord-302530-pp6bl941 110 8 illustrate illustrate VB cord-302530-pp6bl941 110 9 the the DT cord-302530-pp6bl941 110 10 effects effect NNS cord-302530-pp6bl941 110 11 of of IN cord-302530-pp6bl941 110 12 the the DT cord-302530-pp6bl941 110 13 magnitude magnitude NN cord-302530-pp6bl941 110 14 of of IN cord-302530-pp6bl941 110 15 n n NN cord-302530-pp6bl941 110 16 , , , cord-302530-pp6bl941 110 17 ΔC ΔC NNP cord-302530-pp6bl941 110 18 p p NN cord-302530-pp6bl941 110 19 and and CC cord-302530-pp6bl941 110 20 ΔS ΔS NNP cord-302530-pp6bl941 110 21 a_immob a_immob NNP cord-302530-pp6bl941 110 22 on on IN cord-302530-pp6bl941 110 23 the the DT cord-302530-pp6bl941 110 24 temperature temperature NN cord-302530-pp6bl941 110 25 sensitivity sensitivity NN cord-302530-pp6bl941 110 26 of of IN cord-302530-pp6bl941 110 27 virus virus NN cord-302530-pp6bl941 110 28 binding bind VBG cord-302530-pp6bl941 110 29 . . . cord-302530-pp6bl941 111 1 These these DT cord-302530-pp6bl941 111 2 are:-1 are:-1 NNP cord-302530-pp6bl941 112 1 The the DT cord-302530-pp6bl941 112 2 predicted predict VBN cord-302530-pp6bl941 112 3 effect effect NN cord-302530-pp6bl941 112 4 of of IN cord-302530-pp6bl941 112 5 the the DT cord-302530-pp6bl941 112 6 magnitude magnitude NN cord-302530-pp6bl941 112 7 of of IN cord-302530-pp6bl941 112 8 ΔC ΔC NNP cord-302530-pp6bl941 112 9 p p NN cord-302530-pp6bl941 112 10 on on IN cord-302530-pp6bl941 112 11 the the DT cord-302530-pp6bl941 112 12 temperature temperature NN cord-302530-pp6bl941 112 13 dependence dependence NN cord-302530-pp6bl941 112 14 of of IN cord-302530-pp6bl941 112 15 Dengue Dengue NNP cord-302530-pp6bl941 112 16 virus virus NN cord-302530-pp6bl941 112 17 ( ( -LRB- cord-302530-pp6bl941 112 18 DENV DENV NNP cord-302530-pp6bl941 112 19 ) ) -RRB- cord-302530-pp6bl941 112 20 transmission transmission NN cord-302530-pp6bl941 112 21 by by IN cord-302530-pp6bl941 112 22 Aedes Aedes NNP cord-302530-pp6bl941 112 23 albopictus albopictus NN cord-302530-pp6bl941 112 24 ; ; : cord-302530-pp6bl941 112 25 2 2 LS cord-302530-pp6bl941 112 26 The the DT cord-302530-pp6bl941 112 27 predicted predict VBN cord-302530-pp6bl941 112 28 effect effect NN cord-302530-pp6bl941 112 29 of of IN cord-302530-pp6bl941 112 30 the the DT cord-302530-pp6bl941 112 31 magnitude magnitude NN cord-302530-pp6bl941 112 32 of of IN cord-302530-pp6bl941 112 33 ΔC ΔC NNP cord-302530-pp6bl941 112 34 p p NN cord-302530-pp6bl941 112 35 on on IN cord-302530-pp6bl941 112 36 the the DT cord-302530-pp6bl941 112 37 temperature temperature NN cord-302530-pp6bl941 112 38 peak peak NN cord-302530-pp6bl941 112 39 observed observe VBD cord-302530-pp6bl941 112 40 for for IN cord-302530-pp6bl941 112 41 the the DT cord-302530-pp6bl941 112 42 specific specific JJ cord-302530-pp6bl941 112 43 binding binding NN cord-302530-pp6bl941 112 44 of of IN cord-302530-pp6bl941 112 45 Western western JJ cord-302530-pp6bl941 112 46 equine equine JJ cord-302530-pp6bl941 112 47 encephalitis encephalitis NN cord-302530-pp6bl941 112 48 virus virus NN cord-302530-pp6bl941 112 49 ( ( -LRB- cord-302530-pp6bl941 112 50 WEEV WEEV NNP cord-302530-pp6bl941 112 51 ) ) -RRB- cord-302530-pp6bl941 112 52 to to TO cord-302530-pp6bl941 112 53 susceptible susceptible VB cord-302530-pp6bl941 112 54 Culex Culex NNP cord-302530-pp6bl941 112 55 tarsalis tarsalis NNP cord-302530-pp6bl941 112 56 brush brush NN cord-302530-pp6bl941 112 57 border border NN cord-302530-pp6bl941 112 58 fragments fragment NNS cord-302530-pp6bl941 112 59 ( ( -LRB- cord-302530-pp6bl941 112 60 BBFs BBFs NNP cord-302530-pp6bl941 112 61 ) ) -RRB- cord-302530-pp6bl941 112 62 ; ; : cord-302530-pp6bl941 112 63 3 3 CD cord-302530-pp6bl941 112 64 A a DT cord-302530-pp6bl941 112 65 large large JJ cord-302530-pp6bl941 112 66 negative negative JJ cord-302530-pp6bl941 112 67 ΔC δc NN cord-302530-pp6bl941 112 68 p p NN cord-302530-pp6bl941 112 69 for for IN cord-302530-pp6bl941 112 70 a a DT cord-302530-pp6bl941 112 71 protein protein NN cord-302530-pp6bl941 112 72 : : : cord-302530-pp6bl941 113 1 protein protein NN cord-302530-pp6bl941 113 2 GP GP NNP cord-302530-pp6bl941 113 3 / / SYM cord-302530-pp6bl941 113 4 Cr cr NN cord-302530-pp6bl941 113 5 system system NN cord-302530-pp6bl941 113 6 as as IN cord-302530-pp6bl941 113 7 represented represent VBN cord-302530-pp6bl941 113 8 by by IN cord-302530-pp6bl941 113 9 HIV HIV NNP cord-302530-pp6bl941 113 10 gp120 gp120 NNP cord-302530-pp6bl941 113 11 : : : cord-302530-pp6bl941 114 1 CD4 CD4 NNP cord-302530-pp6bl941 114 2 diminishes diminish VBZ cord-302530-pp6bl941 114 3 host host NN cord-302530-pp6bl941 114 4 cell cell NN cord-302530-pp6bl941 114 5 binding bind VBG cord-302530-pp6bl941 114 6 at at IN cord-302530-pp6bl941 114 7 human human JJ cord-302530-pp6bl941 114 8 body body NN cord-302530-pp6bl941 114 9 temperature temperature NN cord-302530-pp6bl941 114 10 ; ; : cord-302530-pp6bl941 114 11 4 4 CD cord-302530-pp6bl941 114 12 A a DT cord-302530-pp6bl941 114 13 large large JJ cord-302530-pp6bl941 114 14 virus virus NN cord-302530-pp6bl941 114 15 diameter diameter NN cord-302530-pp6bl941 114 16 as as IN cord-302530-pp6bl941 114 17 for for IN cord-302530-pp6bl941 114 18 the the DT cord-302530-pp6bl941 114 19 HIV HIV NNP cord-302530-pp6bl941 114 20 virion virion NN cord-302530-pp6bl941 114 21 diminishes diminish VBZ cord-302530-pp6bl941 114 22 host host NN cord-302530-pp6bl941 114 23 cell cell NN cord-302530-pp6bl941 114 24 binding bind VBG cord-302530-pp6bl941 114 25 at at IN cord-302530-pp6bl941 114 26 the the DT cord-302530-pp6bl941 114 27 higher high JJR cord-302530-pp6bl941 114 28 temperature temperature NN cord-302530-pp6bl941 114 29 of of IN cord-302530-pp6bl941 114 30 the the DT cord-302530-pp6bl941 114 31 human human JJ cord-302530-pp6bl941 114 32 body body NN cord-302530-pp6bl941 114 33 through through IN cord-302530-pp6bl941 114 34 the the DT cord-302530-pp6bl941 114 35 large large JJ cord-302530-pp6bl941 114 36 negative negative JJ cord-302530-pp6bl941 114 37 ΔS ΔS NNP cord-302530-pp6bl941 114 38 a_immob a_immob NNP cord-302530-pp6bl941 114 39 ; ; : cord-302530-pp6bl941 114 40 5 5 CD cord-302530-pp6bl941 114 41 Non non JJ cord-302530-pp6bl941 114 42 - - JJ cord-302530-pp6bl941 114 43 specific specific JJ cord-302530-pp6bl941 114 44 attachment attachment NN cord-302530-pp6bl941 114 45 factors factor NNS cord-302530-pp6bl941 114 46 may may MD cord-302530-pp6bl941 114 47 partially partially RB cord-302530-pp6bl941 114 48 overcome overcome VB cord-302530-pp6bl941 114 49 the the DT cord-302530-pp6bl941 114 50 unfavourable unfavourable JJ cord-302530-pp6bl941 114 51 ΔS ΔS NNP cord-302530-pp6bl941 114 52 a_immob a_immob NNP cord-302530-pp6bl941 114 53 and and CC cord-302530-pp6bl941 114 54 hence hence RB cord-302530-pp6bl941 114 55 enhance enhance VB cord-302530-pp6bl941 114 56 specific specific JJ cord-302530-pp6bl941 114 57 HIV HIV NNP cord-302530-pp6bl941 114 58 binding bind VBG cord-302530-pp6bl941 114 59 through through IN cord-302530-pp6bl941 114 60 Env Env NNP cord-302530-pp6bl941 114 61 : : : cord-302530-pp6bl941 115 1 CD4 CD4 NNP cord-302530-pp6bl941 115 2 interactions interaction NNS cord-302530-pp6bl941 115 3 at at IN cord-302530-pp6bl941 115 4 human human JJ cord-302530-pp6bl941 115 5 body body NN cord-302530-pp6bl941 115 6 temperature temperature NN cord-302530-pp6bl941 115 7 ; ; : cord-302530-pp6bl941 115 8 and and CC cord-302530-pp6bl941 115 9 6 6 CD cord-302530-pp6bl941 115 10 Increasing increase VBG cord-302530-pp6bl941 115 11 the the DT cord-302530-pp6bl941 115 12 number number NN cord-302530-pp6bl941 115 13 , , , cord-302530-pp6bl941 115 14 n n NN cord-302530-pp6bl941 115 15 , , , cord-302530-pp6bl941 115 16 of of IN cord-302530-pp6bl941 115 17 GP GP NNP cord-302530-pp6bl941 115 18 / / SYM cord-302530-pp6bl941 115 19 Cr cr NN cord-302530-pp6bl941 115 20 contacts contact NNS cord-302530-pp6bl941 115 21 with with IN cord-302530-pp6bl941 115 22 temperature temperature NN cord-302530-pp6bl941 115 23 to to TO cord-302530-pp6bl941 115 24 reproduce reproduce VB cord-302530-pp6bl941 115 25 the the DT cord-302530-pp6bl941 115 26 data datum NNS cord-302530-pp6bl941 115 27 of of IN cord-302530-pp6bl941 115 28 Frey Frey NNP cord-302530-pp6bl941 115 29 et et NNP cord-302530-pp6bl941 115 30 al al NNP cord-302530-pp6bl941 115 31 . . . cord-302530-pp6bl941 116 1 ( ( -LRB- cord-302530-pp6bl941 116 2 1995 1995 CD cord-302530-pp6bl941 116 3 ) ) -RRB- cord-302530-pp6bl941 116 4 for for IN cord-302530-pp6bl941 116 5 binding bind VBG cord-302530-pp6bl941 116 6 of of IN cord-302530-pp6bl941 116 7 HIV HIV NNP cord-302530-pp6bl941 116 8 Envexpressing Envexpressing NNP cord-302530-pp6bl941 116 9 cells cell NNS cord-302530-pp6bl941 116 10 to to IN cord-302530-pp6bl941 116 11 cells cell NNS cord-302530-pp6bl941 116 12 expressing express VBG cord-302530-pp6bl941 116 13 CD4 CD4 NNP cord-302530-pp6bl941 116 14 . . . cord-302530-pp6bl941 117 1 It -PRON- PRP cord-302530-pp6bl941 117 2 may may MD cord-302530-pp6bl941 117 3 be be VB cord-302530-pp6bl941 117 4 thought think VBN cord-302530-pp6bl941 117 5 there there EX cord-302530-pp6bl941 117 6 is be VBZ cord-302530-pp6bl941 117 7 little little JJ cord-302530-pp6bl941 117 8 point point NN cord-302530-pp6bl941 117 9 in in IN cord-302530-pp6bl941 117 10 modelling model VBG cord-302530-pp6bl941 117 11 HIV HIV NNP cord-302530-pp6bl941 117 12 binding bind VBG cord-302530-pp6bl941 117 13 with with IN cord-302530-pp6bl941 117 14 temperature temperature NN cord-302530-pp6bl941 117 15 because because IN cord-302530-pp6bl941 117 16 HIV HIV NNP cord-302530-pp6bl941 117 17 only only RB cord-302530-pp6bl941 117 18 infects infect VBZ cord-302530-pp6bl941 117 19 human human JJ cord-302530-pp6bl941 117 20 hosts host NNS cord-302530-pp6bl941 117 21 at~37 at~37 NNP cord-302530-pp6bl941 117 22 ° ° NN cord-302530-pp6bl941 117 23 C C NNP cord-302530-pp6bl941 117 24 . . . cord-302530-pp6bl941 118 1 However however RB cord-302530-pp6bl941 118 2 , , , cord-302530-pp6bl941 118 3 the the DT cord-302530-pp6bl941 118 4 model model NN cord-302530-pp6bl941 118 5 here here RB cord-302530-pp6bl941 118 6 suggests suggest VBZ cord-302530-pp6bl941 118 7 mammalian mammalian JJ cord-302530-pp6bl941 118 8 temperature temperature NN cord-302530-pp6bl941 118 9 may may MD cord-302530-pp6bl941 118 10 be be VB cord-302530-pp6bl941 118 11 a a DT cord-302530-pp6bl941 118 12 constraint constraint NN cord-302530-pp6bl941 118 13 on on IN cord-302530-pp6bl941 118 14 HIV HIV NNP cord-302530-pp6bl941 118 15 binding binding NN cord-302530-pp6bl941 118 16 ( ( -LRB- cord-302530-pp6bl941 118 17 due due IN cord-302530-pp6bl941 118 18 to to IN cord-302530-pp6bl941 118 19 the the DT cord-302530-pp6bl941 118 20 large large JJ cord-302530-pp6bl941 118 21 negative negative JJ cord-302530-pp6bl941 118 22 ΔC ΔC NNP cord-302530-pp6bl941 118 23 p p NN cord-302530-pp6bl941 118 24 and and CC cord-302530-pp6bl941 118 25 ΔS ΔS NNP cord-302530-pp6bl941 118 26 a_immob a_immob NNP cord-302530-pp6bl941 118 27 ) ) -RRB- cord-302530-pp6bl941 118 28 in in IN cord-302530-pp6bl941 118 29 effect effect NN cord-302530-pp6bl941 118 30 exposing expose VBG cord-302530-pp6bl941 118 31 a a DT cord-302530-pp6bl941 118 32 potential potential JJ cord-302530-pp6bl941 118 33 weakness weakness NN cord-302530-pp6bl941 118 34 in in IN cord-302530-pp6bl941 118 35 the the DT cord-302530-pp6bl941 118 36 HIV HIV NNP cord-302530-pp6bl941 118 37 infection infection NN cord-302530-pp6bl941 118 38 process process NN cord-302530-pp6bl941 118 39 which which WDT cord-302530-pp6bl941 118 40 could could MD cord-302530-pp6bl941 118 41 be be VB cord-302530-pp6bl941 118 42 exploited exploit VBN cord-302530-pp6bl941 118 43 for for IN cord-302530-pp6bl941 118 44 antiviral antiviral JJ cord-302530-pp6bl941 118 45 therapy therapy NN cord-302530-pp6bl941 118 46 . . . cord-302530-pp6bl941 119 1 The the DT cord-302530-pp6bl941 119 2 implications implication NNS cord-302530-pp6bl941 119 3 of of IN cord-302530-pp6bl941 119 4 making make VBG cord-302530-pp6bl941 119 5 ΔS ΔS NNP cord-302530-pp6bl941 119 6 a_immob a_immob NNP cord-302530-pp6bl941 119 7 more more RBR cord-302530-pp6bl941 119 8 negative negative JJ cord-302530-pp6bl941 119 9 are be VBP cord-302530-pp6bl941 119 10 considered consider VBN cord-302530-pp6bl941 119 11 here here RB cord-302530-pp6bl941 119 12 as as IN cord-302530-pp6bl941 119 13 a a DT cord-302530-pp6bl941 119 14 novel novel JJ cord-302530-pp6bl941 119 15 approach approach NN cord-302530-pp6bl941 119 16 to to IN cord-302530-pp6bl941 119 17 developing develop VBG cord-302530-pp6bl941 119 18 antiviral antiviral JJ cord-302530-pp6bl941 119 19 therapies therapy NNS cord-302530-pp6bl941 119 20 with with IN cord-302530-pp6bl941 119 21 reference reference NN cord-302530-pp6bl941 119 22 to to IN cord-302530-pp6bl941 119 23 Antoine Antoine NNP cord-302530-pp6bl941 119 24 et et FW cord-302530-pp6bl941 119 25 al al NNP cord-302530-pp6bl941 119 26 . . . cord-302530-pp6bl941 120 1 ( ( -LRB- cord-302530-pp6bl941 120 2 2012 2012 CD cord-302530-pp6bl941 120 3 ) ) -RRB- cord-302530-pp6bl941 120 4 using use VBG cord-302530-pp6bl941 120 5 zinc zinc NN cord-302530-pp6bl941 120 6 oxide oxide NN cord-302530-pp6bl941 120 7 nanoparticles nanoparticle NNS cord-302530-pp6bl941 120 8 for for IN cord-302530-pp6bl941 120 9 preventing prevent VBG cord-302530-pp6bl941 120 10 infection infection NN cord-302530-pp6bl941 120 11 by by IN cord-302530-pp6bl941 120 12 herpes herpes NN cord-302530-pp6bl941 120 13 simplex simplex NNP cord-302530-pp6bl941 120 14 virus virus NN cord-302530-pp6bl941 120 15 type type NN cord-302530-pp6bl941 120 16 2 2 CD cord-302530-pp6bl941 120 17 ( ( -LRB- cord-302530-pp6bl941 120 18 HSV-2 HSV-2 NNP cord-302530-pp6bl941 120 19 ) ) -RRB- cord-302530-pp6bl941 120 20 . . . cord-302530-pp6bl941 121 1 2.1 2.1 CD cord-302530-pp6bl941 121 2 . . . cord-302530-pp6bl941 122 1 The the DT cord-302530-pp6bl941 122 2 change change NN cord-302530-pp6bl941 122 3 in in IN cord-302530-pp6bl941 122 4 heat heat NN cord-302530-pp6bl941 122 5 capacity capacity NN cord-302530-pp6bl941 122 6 ( ( -LRB- cord-302530-pp6bl941 122 7 ΔC ΔC NNP cord-302530-pp6bl941 122 8 p p NN cord-302530-pp6bl941 122 9 ) ) -RRB- cord-302530-pp6bl941 122 10 on on IN cord-302530-pp6bl941 122 11 binding binding NN cord-302530-pp6bl941 122 12 of of IN cord-302530-pp6bl941 122 13 virus virus NN cord-302530-pp6bl941 122 14 GP gp NN cord-302530-pp6bl941 122 15 to to IN cord-302530-pp6bl941 122 16 Cr cr NN cord-302530-pp6bl941 122 17 receptors receptor NNS cord-302530-pp6bl941 122 18 on on IN cord-302530-pp6bl941 122 19 the the DT cord-302530-pp6bl941 122 20 host host NN cord-302530-pp6bl941 122 21 cell cell NN cord-302530-pp6bl941 123 1 The the DT cord-302530-pp6bl941 123 2 change change NN cord-302530-pp6bl941 123 3 in in IN cord-302530-pp6bl941 123 4 enthalpy enthalpy NN cord-302530-pp6bl941 123 5 ( ( -LRB- cord-302530-pp6bl941 123 6 H h NN cord-302530-pp6bl941 123 7 ) ) -RRB- cord-302530-pp6bl941 123 8 with with IN cord-302530-pp6bl941 123 9 temperature temperature NN cord-302530-pp6bl941 123 10 ( ( -LRB- cord-302530-pp6bl941 123 11 T t NN cord-302530-pp6bl941 123 12 ) ) -RRB- cord-302530-pp6bl941 123 13 at at IN cord-302530-pp6bl941 123 14 constant constant JJ cord-302530-pp6bl941 123 15 pressure pressure NN cord-302530-pp6bl941 123 16 is be VBZ cord-302530-pp6bl941 123 17 the the DT cord-302530-pp6bl941 123 18 heat heat NN cord-302530-pp6bl941 123 19 capacity capacity NN cord-302530-pp6bl941 123 20 , , , cord-302530-pp6bl941 123 21 C c NN cord-302530-pp6bl941 123 22 p p NN cord-302530-pp6bl941 123 23 . . . cord-302530-pp6bl941 123 24 _SP cord-302530-pp6bl941 124 1 ( ( -LRB- cord-302530-pp6bl941 124 2 Eq Eq NNP cord-302530-pp6bl941 124 3 . . NNP cord-302530-pp6bl941 124 4 10 10 CD cord-302530-pp6bl941 124 5 ) ) -RRB- cord-302530-pp6bl941 125 1 Integrating integrate VBG cord-302530-pp6bl941 125 2 with with IN cord-302530-pp6bl941 125 3 respect respect NN cord-302530-pp6bl941 125 4 to to IN cord-302530-pp6bl941 125 5 temperature temperature NN cord-302530-pp6bl941 125 6 relates relate VBZ cord-302530-pp6bl941 125 7 the the DT cord-302530-pp6bl941 125 8 absolute absolute JJ cord-302530-pp6bl941 125 9 enthalpy enthalpy NN cord-302530-pp6bl941 125 10 ( ( -LRB- cord-302530-pp6bl941 125 11 H h NN cord-302530-pp6bl941 125 12 T t NN cord-302530-pp6bl941 125 13 ) ) -RRB- cord-302530-pp6bl941 125 14 at at IN cord-302530-pp6bl941 125 15 temperature temperature NN cord-302530-pp6bl941 125 16 T t NN cord-302530-pp6bl941 125 17 to to IN cord-302530-pp6bl941 125 18 that that DT cord-302530-pp6bl941 125 19 ( ( -LRB- cord-302530-pp6bl941 125 20 H h NN cord-302530-pp6bl941 125 21 T0 T0 NNP cord-302530-pp6bl941 125 22 ) ) -RRB- cord-302530-pp6bl941 125 23 at at IN cord-302530-pp6bl941 125 24 a a DT cord-302530-pp6bl941 125 25 given give VBN cord-302530-pp6bl941 125 26 reference reference NN cord-302530-pp6bl941 125 27 temperature temperature NN cord-302530-pp6bl941 125 28 T T NNP cord-302530-pp6bl941 125 29 0 0 CD cord-302530-pp6bl941 125 30 through through IN cord-302530-pp6bl941 125 31 C c NN cord-302530-pp6bl941 125 32 p p NN cord-302530-pp6bl941 125 33 according accord VBG cord-302530-pp6bl941 125 34 to to IN cord-302530-pp6bl941 125 35 Eq Eq NNP cord-302530-pp6bl941 125 36 . . . cord-302530-pp6bl941 126 1 ( ( -LRB- cord-302530-pp6bl941 126 2 1 1 LS cord-302530-pp6bl941 126 3 ) ) -RRB- cord-302530-pp6bl941 126 4 ( ( -LRB- cord-302530-pp6bl941 126 5 see see VB cord-302530-pp6bl941 126 6 Table table NN cord-302530-pp6bl941 126 7 1 1 CD cord-302530-pp6bl941 126 8 ) ) -RRB- cord-302530-pp6bl941 126 9 . . . cord-302530-pp6bl941 127 1 The the DT cord-302530-pp6bl941 127 2 attachment attachment NN cord-302530-pp6bl941 127 3 of of IN cord-302530-pp6bl941 127 4 a a DT cord-302530-pp6bl941 127 5 virus virus NN cord-302530-pp6bl941 127 6 to to IN cord-302530-pp6bl941 127 7 its -PRON- PRP$ cord-302530-pp6bl941 127 8 host host NN cord-302530-pp6bl941 127 9 cell cell NN cord-302530-pp6bl941 127 10 is be VBZ cord-302530-pp6bl941 127 11 driven drive VBN cord-302530-pp6bl941 127 12 by by IN cord-302530-pp6bl941 127 13 the the DT cord-302530-pp6bl941 127 14 n n NNP cord-302530-pp6bl941 127 15 individual individual JJ cord-302530-pp6bl941 127 16 interactions interaction NNS cord-302530-pp6bl941 127 17 between between IN cord-302530-pp6bl941 127 18 GP GP NNP cord-302530-pp6bl941 127 19 and and CC cord-302530-pp6bl941 127 20 Cr Cr NNP cord-302530-pp6bl941 127 21 made make VBD cord-302530-pp6bl941 127 22 on on RP cord-302530-pp6bl941 127 23 binding bind VBG cord-302530-pp6bl941 127 24 as as IN cord-302530-pp6bl941 127 25 represented represent VBN cord-302530-pp6bl941 127 26 by by IN cord-302530-pp6bl941 127 27 the the DT cord-302530-pp6bl941 127 28 dynamic dynamic JJ cord-302530-pp6bl941 127 29 equilibrium equilibrium NN cord-302530-pp6bl941 127 30 in in IN cord-302530-pp6bl941 127 31 Eq Eq NNP cord-302530-pp6bl941 127 32 . . . cord-302530-pp6bl941 128 1 ( ( -LRB- cord-302530-pp6bl941 128 2 2 2 LS cord-302530-pp6bl941 128 3 ) ) -RRB- cord-302530-pp6bl941 128 4 . . . cord-302530-pp6bl941 129 1 The the DT cord-302530-pp6bl941 129 2 change change NN cord-302530-pp6bl941 129 3 in in IN cord-302530-pp6bl941 129 4 enthalpy enthalpy NN cord-302530-pp6bl941 129 5 for for IN cord-302530-pp6bl941 129 6 GP gp NN cord-302530-pp6bl941 129 7 binding bind VBG cord-302530-pp6bl941 129 8 to to IN cord-302530-pp6bl941 129 9 Cr Cr NNP cord-302530-pp6bl941 129 10 at at IN cord-302530-pp6bl941 129 11 temperature temperature NN cord-302530-pp6bl941 129 12 T t NN cord-302530-pp6bl941 129 13 , , , cord-302530-pp6bl941 129 14 ΔH ΔH NNP cord-302530-pp6bl941 129 15 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 129 16 , , , cord-302530-pp6bl941 129 17 is be VBZ cord-302530-pp6bl941 129 18 given give VBN cord-302530-pp6bl941 129 19 by by IN cord-302530-pp6bl941 129 20 Eq Eq NNP cord-302530-pp6bl941 129 21 . . . cord-302530-pp6bl941 130 1 ( ( -LRB- cord-302530-pp6bl941 130 2 3 3 CD cord-302530-pp6bl941 130 3 ) ) -RRB- cord-302530-pp6bl941 130 4 . . . cord-302530-pp6bl941 131 1 Substituting substitute VBG cord-302530-pp6bl941 131 2 Eq Eq NNP cord-302530-pp6bl941 131 3 . . . cord-302530-pp6bl941 132 1 ( ( -LRB- cord-302530-pp6bl941 132 2 1 1 LS cord-302530-pp6bl941 132 3 ) ) -RRB- cord-302530-pp6bl941 132 4 into into IN cord-302530-pp6bl941 132 5 Eq Eq NNP cord-302530-pp6bl941 132 6 . . . cord-302530-pp6bl941 133 1 ( ( -LRB- cord-302530-pp6bl941 133 2 3 3 LS cord-302530-pp6bl941 133 3 ) ) -RRB- cord-302530-pp6bl941 133 4 for for IN cord-302530-pp6bl941 133 5 the the DT cord-302530-pp6bl941 133 6 enthalpies enthalpy NNS cord-302530-pp6bl941 133 7 for for IN cord-302530-pp6bl941 133 8 the the DT cord-302530-pp6bl941 133 9 GP.Cr GP.Cr NNP cord-302530-pp6bl941 133 10 complex complex NN cord-302530-pp6bl941 133 11 ( ( -LRB- cord-302530-pp6bl941 133 12 H h NN cord-302530-pp6bl941 133 13 T t NN cord-302530-pp6bl941 133 14 ( ( -LRB- cord-302530-pp6bl941 133 15 GP.Cr GP.Cr NNP cord-302530-pp6bl941 133 16 ) ) -RRB- cord-302530-pp6bl941 133 17 ) ) -RRB- cord-302530-pp6bl941 133 18 , , , cord-302530-pp6bl941 133 19 the the DT cord-302530-pp6bl941 133 20 free free JJ cord-302530-pp6bl941 133 21 GP gp NN cord-302530-pp6bl941 133 22 ( ( -LRB- cord-302530-pp6bl941 133 23 H h NN cord-302530-pp6bl941 133 24 T t NN cord-302530-pp6bl941 133 25 ( ( -LRB- cord-302530-pp6bl941 133 26 GP GP NNP cord-302530-pp6bl941 133 27 ) ) -RRB- cord-302530-pp6bl941 133 28 ) ) -RRB- cord-302530-pp6bl941 133 29 and and CC cord-302530-pp6bl941 133 30 the the DT cord-302530-pp6bl941 133 31 free free JJ cord-302530-pp6bl941 133 32 Cr cr NN cord-302530-pp6bl941 133 33 ( ( -LRB- cord-302530-pp6bl941 133 34 H h NN cord-302530-pp6bl941 133 35 T t NN cord-302530-pp6bl941 133 36 ( ( -LRB- cord-302530-pp6bl941 133 37 Cr cr NN cord-302530-pp6bl941 133 38 ) ) -RRB- cord-302530-pp6bl941 133 39 ) ) -RRB- cord-302530-pp6bl941 133 40 relates relate VBZ cord-302530-pp6bl941 133 41 the the DT cord-302530-pp6bl941 133 42 enthalpy enthalpy NN cord-302530-pp6bl941 133 43 change change NN cord-302530-pp6bl941 133 44 for for IN cord-302530-pp6bl941 133 45 GP gp NN cord-302530-pp6bl941 133 46 binding bind VBG cord-302530-pp6bl941 133 47 to to IN cord-302530-pp6bl941 133 48 Cr Cr NNP cord-302530-pp6bl941 133 49 at at IN cord-302530-pp6bl941 133 50 temperature temperature NN cord-302530-pp6bl941 133 51 T t NN cord-302530-pp6bl941 133 52 , , , cord-302530-pp6bl941 133 53 ΔH ΔH NNP cord-302530-pp6bl941 133 54 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 133 55 , , , cord-302530-pp6bl941 133 56 to to IN cord-302530-pp6bl941 133 57 that that DT cord-302530-pp6bl941 133 58 ( ( -LRB- cord-302530-pp6bl941 133 59 ΔH ΔH NNP cord-302530-pp6bl941 133 60 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 133 61 ) ) -RRB- cord-302530-pp6bl941 133 62 measured measure VBN cord-302530-pp6bl941 133 63 experimentally experimentally RB cord-302530-pp6bl941 133 64 at at IN cord-302530-pp6bl941 133 65 temperature temperature NN cord-302530-pp6bl941 133 66 T t NN cord-302530-pp6bl941 133 67 0 0 CD cord-302530-pp6bl941 134 1 ( ( -LRB- cord-302530-pp6bl941 134 2 Du Du NNP cord-302530-pp6bl941 134 3 et et FW cord-302530-pp6bl941 134 4 al al NNP cord-302530-pp6bl941 134 5 . . NNP cord-302530-pp6bl941 134 6 , , , cord-302530-pp6bl941 134 7 2016 2016 CD cord-302530-pp6bl941 134 8 ) ) -RRB- cord-302530-pp6bl941 135 1 according accord VBG cord-302530-pp6bl941 135 2 to to IN cord-302530-pp6bl941 135 3 Eq Eq NNP cord-302530-pp6bl941 135 4 . . . cord-302530-pp6bl941 136 1 ( ( -LRB- cord-302530-pp6bl941 136 2 4 4 LS cord-302530-pp6bl941 136 3 ) ) -RRB- cord-302530-pp6bl941 136 4 where where WRB cord-302530-pp6bl941 136 5 ΔC ΔC NNP cord-302530-pp6bl941 136 6 p p NNP cord-302530-pp6bl941 136 7 is be VBZ cord-302530-pp6bl941 136 8 the the DT cord-302530-pp6bl941 136 9 change change NN cord-302530-pp6bl941 136 10 in in IN cord-302530-pp6bl941 136 11 heat heat NN cord-302530-pp6bl941 136 12 capacity capacity NN cord-302530-pp6bl941 136 13 defined define VBN cord-302530-pp6bl941 136 14 as as IN cord-302530-pp6bl941 136 15 the the DT cord-302530-pp6bl941 136 16 difference difference NN cord-302530-pp6bl941 136 17 between between IN cord-302530-pp6bl941 136 18 the the DT cord-302530-pp6bl941 136 19 heat heat NN cord-302530-pp6bl941 136 20 capacities capacity NNS cord-302530-pp6bl941 136 21 of of IN cord-302530-pp6bl941 136 22 the the DT cord-302530-pp6bl941 136 23 GP.Cr GP.Cr NNP cord-302530-pp6bl941 136 24 complex complex NN cord-302530-pp6bl941 136 25 and and CC cord-302530-pp6bl941 136 26 the the DT cord-302530-pp6bl941 136 27 sum sum NN cord-302530-pp6bl941 136 28 of of IN cord-302530-pp6bl941 136 29 the the DT cord-302530-pp6bl941 136 30 heat heat NN cord-302530-pp6bl941 136 31 capacities capacity NNS cord-302530-pp6bl941 136 32 of of IN cord-302530-pp6bl941 136 33 the the DT cord-302530-pp6bl941 136 34 free free JJ cord-302530-pp6bl941 136 35 GP gp NN cord-302530-pp6bl941 136 36 and and CC cord-302530-pp6bl941 136 37 Cr cr NN cord-302530-pp6bl941 136 38 molecules molecule NNS cord-302530-pp6bl941 136 39 as as IN cord-302530-pp6bl941 136 40 given give VBN cord-302530-pp6bl941 136 41 by by IN cord-302530-pp6bl941 136 42 Eq Eq NNP cord-302530-pp6bl941 136 43 . . . cord-302530-pp6bl941 137 1 ( ( -LRB- cord-302530-pp6bl941 137 2 5 5 LS cord-302530-pp6bl941 137 3 ) ) -RRB- cord-302530-pp6bl941 137 4 . . . cord-302530-pp6bl941 138 1 Similarly similarly RB cord-302530-pp6bl941 138 2 the the DT cord-302530-pp6bl941 138 3 entropy entropy NN cord-302530-pp6bl941 138 4 change change NN cord-302530-pp6bl941 138 5 ( ( -LRB- cord-302530-pp6bl941 138 6 ΔS ΔS NNP cord-302530-pp6bl941 138 7 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 138 8 ) ) -RRB- cord-302530-pp6bl941 138 9 for for IN cord-302530-pp6bl941 138 10 GP gp NN cord-302530-pp6bl941 138 11 binding bind VBG cord-302530-pp6bl941 138 12 to to IN cord-302530-pp6bl941 138 13 Cr Cr NNP cord-302530-pp6bl941 138 14 at at IN cord-302530-pp6bl941 138 15 temperature temperature NN cord-302530-pp6bl941 138 16 T T NNP cord-302530-pp6bl941 138 17 is be VBZ cord-302530-pp6bl941 138 18 related relate VBN cord-302530-pp6bl941 138 19 to to IN cord-302530-pp6bl941 138 20 that that DT cord-302530-pp6bl941 138 21 ( ( -LRB- cord-302530-pp6bl941 138 22 ΔS ΔS NNP cord-302530-pp6bl941 138 23 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 138 24 ) ) -RRB- cord-302530-pp6bl941 138 25 measured measure VBN cord-302530-pp6bl941 138 26 experimentally experimentally RB cord-302530-pp6bl941 138 27 at at IN cord-302530-pp6bl941 138 28 temperature temperature NN cord-302530-pp6bl941 138 29 T t NN cord-302530-pp6bl941 138 30 0 0 CD cord-302530-pp6bl941 139 1 ( ( -LRB- cord-302530-pp6bl941 139 2 Du Du NNP cord-302530-pp6bl941 139 3 et et FW cord-302530-pp6bl941 139 4 al al NNP cord-302530-pp6bl941 139 5 . . NNP cord-302530-pp6bl941 139 6 , , , cord-302530-pp6bl941 139 7 2016 2016 CD cord-302530-pp6bl941 139 8 ) ) -RRB- cord-302530-pp6bl941 140 1 according accord VBG cord-302530-pp6bl941 140 2 to to IN cord-302530-pp6bl941 140 3 Eq Eq NNP cord-302530-pp6bl941 140 4 . . . cord-302530-pp6bl941 141 1 ( ( -LRB- cord-302530-pp6bl941 141 2 6 6 CD cord-302530-pp6bl941 141 3 ) ) -RRB- cord-302530-pp6bl941 141 4 . . . cord-302530-pp6bl941 142 1 Modelling model VBG cord-302530-pp6bl941 142 2 the the DT cord-302530-pp6bl941 142 3 effect effect NN cord-302530-pp6bl941 142 4 of of IN cord-302530-pp6bl941 142 5 temperature temperature NN cord-302530-pp6bl941 142 6 on on IN cord-302530-pp6bl941 142 7 ΔH ΔH NNP cord-302530-pp6bl941 142 8 a_virus_T a_virus_T NNP cord-302530-pp6bl941 142 9 and and CC cord-302530-pp6bl941 142 10 ΔS ΔS NNP cord-302530-pp6bl941 142 11 a_virus_T a_virus_T NNP cord-302530-pp6bl941 142 12 and and CC cord-302530-pp6bl941 142 13 hence hence RB cord-302530-pp6bl941 142 14 K K NNP cord-302530-pp6bl941 142 15 a_virus_T a_virus_T NNP cord-302530-pp6bl941 142 16 ΔH ΔH NNP cord-302530-pp6bl941 142 17 a_virus_T a_virus_T NNP cord-302530-pp6bl941 142 18 and and CC cord-302530-pp6bl941 142 19 ΔS ΔS NNP cord-302530-pp6bl941 142 20 a_virus_T a_virus_T NNP cord-302530-pp6bl941 142 21 are be VBP cord-302530-pp6bl941 142 22 the the DT cord-302530-pp6bl941 142 23 changes change NNS cord-302530-pp6bl941 142 24 in in IN cord-302530-pp6bl941 142 25 enthalpy enthalpy NN cord-302530-pp6bl941 142 26 and and CC cord-302530-pp6bl941 142 27 entropy entropy NN cord-302530-pp6bl941 142 28 respectively respectively RB cord-302530-pp6bl941 142 29 on on IN cord-302530-pp6bl941 142 30 binding binding NN cord-302530-pp6bl941 142 31 of of IN cord-302530-pp6bl941 142 32 virus virus NN cord-302530-pp6bl941 142 33 to to TO cord-302530-pp6bl941 142 34 host host VB cord-302530-pp6bl941 142 35 cell cell NN cord-302530-pp6bl941 142 36 at at IN cord-302530-pp6bl941 142 37 temperature temperature NN cord-302530-pp6bl941 142 38 T. t. NN cord-302530-pp6bl941 143 1 Substituting substitute VBG cord-302530-pp6bl941 143 2 the the DT cord-302530-pp6bl941 143 3 terms term NNS cord-302530-pp6bl941 143 4 for for IN cord-302530-pp6bl941 143 5 ΔH ΔH NNP cord-302530-pp6bl941 143 6 a_virus_T a_virus_T NNP cord-302530-pp6bl941 143 7 ( ( -LRB- cord-302530-pp6bl941 143 8 Eq Eq NNP cord-302530-pp6bl941 143 9 . . . cord-302530-pp6bl941 144 1 ( ( -LRB- cord-302530-pp6bl941 144 2 7 7 CD cord-302530-pp6bl941 144 3 ) ) -RRB- cord-302530-pp6bl941 144 4 ) ) -RRB- cord-302530-pp6bl941 145 1 and and CC cord-302530-pp6bl941 145 2 ΔS ΔS NNP cord-302530-pp6bl941 145 3 a_virus_T a_virus_T NNP cord-302530-pp6bl941 146 1 ( ( -LRB- cord-302530-pp6bl941 146 2 Eq Eq NNP cord-302530-pp6bl941 146 3 . . . cord-302530-pp6bl941 147 1 ( ( -LRB- cord-302530-pp6bl941 147 2 8) 8) NNP cord-302530-pp6bl941 147 3 ) ) -RRB- cord-302530-pp6bl941 147 4 into into IN cord-302530-pp6bl941 147 5 Eq Eq NNP cord-302530-pp6bl941 147 6 . . . cord-302530-pp6bl941 148 1 ( ( -LRB- cord-302530-pp6bl941 148 2 9 9 LS cord-302530-pp6bl941 148 3 ) ) -RRB- cord-302530-pp6bl941 148 4 expresses express VBZ cord-302530-pp6bl941 148 5 ΔG ΔG NNP cord-302530-pp6bl941 148 6 a_virus_T a_virus_T NNP cord-302530-pp6bl941 148 7 in in IN cord-302530-pp6bl941 148 8 terms term NNS cord-302530-pp6bl941 148 9 of of IN cord-302530-pp6bl941 148 10 n n NN cord-302530-pp6bl941 148 11 , , , cord-302530-pp6bl941 148 12 ΔS ΔS NNP cord-302530-pp6bl941 148 13 a_immob a_immob NNP cord-302530-pp6bl941 148 14 , , , cord-302530-pp6bl941 148 15 ΔH ΔH NNP cord-302530-pp6bl941 148 16 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 148 17 and and CC cord-302530-pp6bl941 148 18 ΔS ΔS NNP cord-302530-pp6bl941 148 19 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 149 1 ( ( -LRB- cord-302530-pp6bl941 149 2 Eq Eq NNP cord-302530-pp6bl941 149 3 . . . cord-302530-pp6bl941 150 1 ( ( -LRB- cord-302530-pp6bl941 150 2 10 10 CD cord-302530-pp6bl941 150 3 ) ) -RRB- cord-302530-pp6bl941 150 4 ) ) -RRB- cord-302530-pp6bl941 150 5 where where WRB cord-302530-pp6bl941 150 6 ΔG ΔG NNP cord-302530-pp6bl941 150 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 150 8 is be VBZ cord-302530-pp6bl941 150 9 the the DT cord-302530-pp6bl941 150 10 change change NN cord-302530-pp6bl941 150 11 in in IN cord-302530-pp6bl941 150 12 Gibbs Gibbs NNP cord-302530-pp6bl941 150 13 free free JJ cord-302530-pp6bl941 150 14 energy energy NN cord-302530-pp6bl941 150 15 on on IN cord-302530-pp6bl941 150 16 association association NNP cord-302530-pp6bl941 150 17 of of IN cord-302530-pp6bl941 150 18 virus virus NN cord-302530-pp6bl941 150 19 with with IN cord-302530-pp6bl941 150 20 a a DT cord-302530-pp6bl941 150 21 host host NN cord-302530-pp6bl941 150 22 cell cell NN cord-302530-pp6bl941 150 23 at at IN cord-302530-pp6bl941 150 24 temperature temperature NN cord-302530-pp6bl941 150 25 T T NNP cord-302530-pp6bl941 150 26 and and CC cord-302530-pp6bl941 150 27 ΔS ΔS NNP cord-302530-pp6bl941 150 28 a_immob a_immob NNP cord-302530-pp6bl941 150 29 is be VBZ cord-302530-pp6bl941 150 30 the the DT cord-302530-pp6bl941 150 31 change change NN cord-302530-pp6bl941 150 32 in in IN cord-302530-pp6bl941 150 33 entropy entropy NN cord-302530-pp6bl941 150 34 on on IN cord-302530-pp6bl941 150 35 immobilisation immobilisation NN cord-302530-pp6bl941 150 36 of of IN cord-302530-pp6bl941 150 37 the the DT cord-302530-pp6bl941 150 38 whole whole JJ cord-302530-pp6bl941 150 39 virus virus NN cord-302530-pp6bl941 150 40 on on IN cord-302530-pp6bl941 150 41 the the DT cord-302530-pp6bl941 150 42 cell cell NN cord-302530-pp6bl941 150 43 surface surface NN cord-302530-pp6bl941 150 44 ( ( -LRB- cord-302530-pp6bl941 150 45 Gale Gale NNP cord-302530-pp6bl941 150 46 2018 2018 CD cord-302530-pp6bl941 150 47 ; ; : cord-302530-pp6bl941 150 48 2019 2019 CD cord-302530-pp6bl941 150 49 ) ) -RRB- cord-302530-pp6bl941 150 50 . . . cord-302530-pp6bl941 151 1 For for IN cord-302530-pp6bl941 151 2 this this DT cord-302530-pp6bl941 151 3 work work NN cord-302530-pp6bl941 151 4 it -PRON- PRP cord-302530-pp6bl941 151 5 is be VBZ cord-302530-pp6bl941 151 6 assumed assume VBN cord-302530-pp6bl941 151 7 that that IN cord-302530-pp6bl941 151 8 the the DT cord-302530-pp6bl941 151 9 change change NN cord-302530-pp6bl941 151 10 in in IN cord-302530-pp6bl941 151 11 heat heat NN cord-302530-pp6bl941 151 12 capacity capacity NN cord-302530-pp6bl941 151 13 on on IN cord-302530-pp6bl941 151 14 binding binding NN cord-302530-pp6bl941 151 15 of of IN cord-302530-pp6bl941 151 16 a a DT cord-302530-pp6bl941 151 17 virus virus NN cord-302530-pp6bl941 151 18 to to IN cord-302530-pp6bl941 151 19 a a DT cord-302530-pp6bl941 151 20 host host NN cord-302530-pp6bl941 151 21 cell cell NN cord-302530-pp6bl941 151 22 is be VBZ cord-302530-pp6bl941 151 23 determined determine VBN cord-302530-pp6bl941 151 24 by by IN cord-302530-pp6bl941 151 25 the the DT cord-302530-pp6bl941 151 26 change change NN cord-302530-pp6bl941 151 27 in in IN cord-302530-pp6bl941 151 28 heat heat NN cord-302530-pp6bl941 151 29 capacity capacity NN cord-302530-pp6bl941 151 30 on on IN cord-302530-pp6bl941 151 31 interaction interaction NN cord-302530-pp6bl941 151 32 of of IN cord-302530-pp6bl941 151 33 GP GP NNP cord-302530-pp6bl941 151 34 with with IN cord-302530-pp6bl941 151 35 Cr cr NN cord-302530-pp6bl941 151 36 according accord VBG cord-302530-pp6bl941 151 37 to to IN cord-302530-pp6bl941 151 38 Eq Eq NNP cord-302530-pp6bl941 151 39 . . . cord-302530-pp6bl941 152 1 ( ( -LRB- cord-302530-pp6bl941 152 2 5 5 LS cord-302530-pp6bl941 152 3 ) ) -RRB- cord-302530-pp6bl941 152 4 and and CC cord-302530-pp6bl941 152 5 that that IN cord-302530-pp6bl941 152 6 ΔS ΔS NNP cord-302530-pp6bl941 152 7 a_immob a_immob NNP cord-302530-pp6bl941 152 8 in in IN cord-302530-pp6bl941 152 9 Eq Eq NNP cord-302530-pp6bl941 152 10 . . . cord-302530-pp6bl941 153 1 ( ( -LRB- cord-302530-pp6bl941 153 2 10 10 CD cord-302530-pp6bl941 153 3 ) ) -RRB- cord-302530-pp6bl941 153 4 is be VBZ cord-302530-pp6bl941 153 5 unaffected unaffected JJ cord-302530-pp6bl941 153 6 . . . cord-302530-pp6bl941 154 1 In in IN cord-302530-pp6bl941 154 2 effect effect NN cord-302530-pp6bl941 154 3 therefore therefore RB cord-302530-pp6bl941 154 4 the the DT cord-302530-pp6bl941 154 5 heat heat NN cord-302530-pp6bl941 154 6 capacity capacity NN cord-302530-pp6bl941 154 7 of of IN cord-302530-pp6bl941 154 8 the the DT cord-302530-pp6bl941 154 9 " " `` cord-302530-pp6bl941 154 10 bulk bulk NN cord-302530-pp6bl941 154 11 " " '' cord-302530-pp6bl941 154 12 ( ( -LRB- cord-302530-pp6bl941 154 13 i.e. i.e. FW cord-302530-pp6bl941 154 14 non non JJ cord-302530-pp6bl941 154 15 - - JJ cord-302530-pp6bl941 154 16 GP GP NNP cord-302530-pp6bl941 154 17 / / SYM cord-302530-pp6bl941 154 18 Cr Cr NNP cord-302530-pp6bl941 154 19 ) ) -RRB- cord-302530-pp6bl941 154 20 of of IN cord-302530-pp6bl941 154 21 the the DT cord-302530-pp6bl941 154 22 bound bind VBN cord-302530-pp6bl941 154 23 virus virus NN cord-302530-pp6bl941 154 24 / / SYM cord-302530-pp6bl941 154 25 host host NN cord-302530-pp6bl941 154 26 cell cell NN cord-302530-pp6bl941 154 27 is be VBZ cord-302530-pp6bl941 154 28 the the DT cord-302530-pp6bl941 154 29 same same JJ cord-302530-pp6bl941 154 30 as as IN cord-302530-pp6bl941 154 31 the the DT cord-302530-pp6bl941 154 32 sum sum NN cord-302530-pp6bl941 154 33 of of IN cord-302530-pp6bl941 154 34 the the DT cord-302530-pp6bl941 154 35 heat heat NN cord-302530-pp6bl941 154 36 capacities capacity NNS cord-302530-pp6bl941 154 37 for for IN cord-302530-pp6bl941 154 38 the the DT cord-302530-pp6bl941 154 39 free free JJ cord-302530-pp6bl941 154 40 virus virus NN cord-302530-pp6bl941 154 41 and and CC cord-302530-pp6bl941 154 42 free free JJ cord-302530-pp6bl941 154 43 host host NN cord-302530-pp6bl941 154 44 cell cell NN cord-302530-pp6bl941 154 45 . . . cord-302530-pp6bl941 155 1 This this DT cord-302530-pp6bl941 155 2 is be VBZ cord-302530-pp6bl941 155 3 acceptable acceptable JJ cord-302530-pp6bl941 155 4 because because IN cord-302530-pp6bl941 155 5 a a DT cord-302530-pp6bl941 155 6 change change NN cord-302530-pp6bl941 155 7 in in IN cord-302530-pp6bl941 155 8 heat heat NN cord-302530-pp6bl941 155 9 capacity capacity NN cord-302530-pp6bl941 155 10 is be VBZ cord-302530-pp6bl941 155 11 related relate VBN cord-302530-pp6bl941 155 12 to to IN cord-302530-pp6bl941 155 13 a a DT cord-302530-pp6bl941 155 14 change change NN cord-302530-pp6bl941 155 15 in in IN cord-302530-pp6bl941 155 16 conformation conformation NN cord-302530-pp6bl941 155 17 of of IN cord-302530-pp6bl941 155 18 the the DT cord-302530-pp6bl941 155 19 molecular molecular JJ cord-302530-pp6bl941 155 20 components component NNS cord-302530-pp6bl941 155 21 ( ( -LRB- cord-302530-pp6bl941 155 22 Myszka Myszka NNP cord-302530-pp6bl941 155 23 et et NNP cord-302530-pp6bl941 155 24 al al NNP cord-302530-pp6bl941 155 25 . . NNP cord-302530-pp6bl941 155 26 , , , cord-302530-pp6bl941 155 27 2000 2000 CD cord-302530-pp6bl941 155 28 ) ) -RRB- cord-302530-pp6bl941 155 29 and and CC cord-302530-pp6bl941 155 30 the the DT cord-302530-pp6bl941 155 31 conformation conformation NN cord-302530-pp6bl941 155 32 of of IN cord-302530-pp6bl941 155 33 the the DT cord-302530-pp6bl941 155 34 bulk bulk NN cord-302530-pp6bl941 155 35 of of IN cord-302530-pp6bl941 155 36 the the DT cord-302530-pp6bl941 155 37 host host NN cord-302530-pp6bl941 155 38 cell cell NN cord-302530-pp6bl941 155 39 and and CC cord-302530-pp6bl941 155 40 the the DT cord-302530-pp6bl941 155 41 virus virus NN cord-302530-pp6bl941 155 42 would would MD cord-302530-pp6bl941 155 43 be be VB cord-302530-pp6bl941 155 44 unaffected unaffected JJ cord-302530-pp6bl941 155 45 by by IN cord-302530-pp6bl941 155 46 attachment attachment NN cord-302530-pp6bl941 155 47 . . . cord-302530-pp6bl941 156 1 Indeed indeed RB cord-302530-pp6bl941 156 2 , , , cord-302530-pp6bl941 156 3 ΔS ΔS NNP cord-302530-pp6bl941 156 4 a_immob a_immob NNP cord-302530-pp6bl941 156 5 is be VBZ cord-302530-pp6bl941 156 6 mainly mainly RB cord-302530-pp6bl941 156 7 related relate VBN cord-302530-pp6bl941 156 8 to to IN cord-302530-pp6bl941 156 9 changes change NNS cord-302530-pp6bl941 156 10 in in IN cord-302530-pp6bl941 156 11 rotational rotational JJ cord-302530-pp6bl941 156 12 and and CC cord-302530-pp6bl941 156 13 translational translational JJ cord-302530-pp6bl941 156 14 mobility mobility NN cord-302530-pp6bl941 156 15 of of IN cord-302530-pp6bl941 156 16 the the DT cord-302530-pp6bl941 156 17 virus virus NN cord-302530-pp6bl941 156 18 particle particle NN cord-302530-pp6bl941 156 19 as as IN cord-302530-pp6bl941 156 20 a a DT cord-302530-pp6bl941 156 21 whole whole NN cord-302530-pp6bl941 156 22 ( ( -LRB- cord-302530-pp6bl941 156 23 see see VB cord-302530-pp6bl941 156 24 below below RB cord-302530-pp6bl941 156 25 ) ) -RRB- cord-302530-pp6bl941 156 26 and and CC cord-302530-pp6bl941 156 27 does do VBZ cord-302530-pp6bl941 156 28 not not RB cord-302530-pp6bl941 156 29 involve involve VB cord-302530-pp6bl941 156 30 the the DT cord-302530-pp6bl941 156 31 conformational conformational JJ cord-302530-pp6bl941 156 32 changes change NNS cord-302530-pp6bl941 156 33 in in IN cord-302530-pp6bl941 156 34 GP GP NNP cord-302530-pp6bl941 156 35 and and CC cord-302530-pp6bl941 156 36 Cr cr NN cord-302530-pp6bl941 156 37 which which WDT cord-302530-pp6bl941 156 38 are be VBP cord-302530-pp6bl941 156 39 accommodated accommodate VBN cord-302530-pp6bl941 156 40 in in IN cord-302530-pp6bl941 156 41 the the DT cord-302530-pp6bl941 156 42 ΔS ΔS NNP cord-302530-pp6bl941 156 43 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 156 44 term term NN cord-302530-pp6bl941 156 45 ( ( -LRB- cord-302530-pp6bl941 156 46 Gale Gale NNP cord-302530-pp6bl941 156 47 2019 2019 CD cord-302530-pp6bl941 156 48 ) ) -RRB- cord-302530-pp6bl941 156 49 . . . cord-302530-pp6bl941 157 1 Since since IN cord-302530-pp6bl941 157 2 the the DT cord-302530-pp6bl941 157 3 heat heat NN cord-302530-pp6bl941 157 4 capacity capacity NN cord-302530-pp6bl941 157 5 of of IN cord-302530-pp6bl941 157 6 the the DT cord-302530-pp6bl941 157 7 " " `` cord-302530-pp6bl941 157 8 bulk bulk NN cord-302530-pp6bl941 157 9 " " '' cord-302530-pp6bl941 157 10 of of IN cord-302530-pp6bl941 157 11 the the DT cord-302530-pp6bl941 157 12 bound bound JJ cord-302530-pp6bl941 157 13 virus/ virus/ CD cord-302530-pp6bl941 157 14 host host NN cord-302530-pp6bl941 157 15 cell cell NN cord-302530-pp6bl941 157 16 is be VBZ cord-302530-pp6bl941 157 17 the the DT cord-302530-pp6bl941 157 18 same same JJ cord-302530-pp6bl941 157 19 as as IN cord-302530-pp6bl941 157 20 the the DT cord-302530-pp6bl941 157 21 sum sum NN cord-302530-pp6bl941 157 22 of of IN cord-302530-pp6bl941 157 23 the the DT cord-302530-pp6bl941 157 24 heat heat NN cord-302530-pp6bl941 157 25 capacities capacity NNS cord-302530-pp6bl941 157 26 for for IN cord-302530-pp6bl941 157 27 the the DT cord-302530-pp6bl941 157 28 free free JJ cord-302530-pp6bl941 157 29 virus virus NN cord-302530-pp6bl941 157 30 and and CC cord-302530-pp6bl941 157 31 free free JJ cord-302530-pp6bl941 157 32 host host NN cord-302530-pp6bl941 157 33 cell cell NN cord-302530-pp6bl941 157 34 , , , cord-302530-pp6bl941 157 35 ΔC ΔC NNP cord-302530-pp6bl941 157 36 p p NNP cord-302530-pp6bl941 157 37 for for IN cord-302530-pp6bl941 157 38 the the DT cord-302530-pp6bl941 157 39 bulk bulk JJ cord-302530-pp6bl941 157 40 equals equal VBZ cord-302530-pp6bl941 157 41 zero zero CD cord-302530-pp6bl941 157 42 , , , cord-302530-pp6bl941 157 43 and and CC cord-302530-pp6bl941 157 44 according accord VBG cord-302530-pp6bl941 157 45 to to IN cord-302530-pp6bl941 157 46 Eq Eq NNP cord-302530-pp6bl941 157 47 . . . cord-302530-pp6bl941 158 1 ( ( -LRB- cord-302530-pp6bl941 158 2 6 6 LS cord-302530-pp6bl941 158 3 ) ) -RRB- cord-302530-pp6bl941 158 4 therefore therefore RB cord-302530-pp6bl941 158 5 , , , cord-302530-pp6bl941 158 6 ΔS ΔS NNP cord-302530-pp6bl941 158 7 a_immob a_immob NNP cord-302530-pp6bl941 158 8 itself -PRON- PRP cord-302530-pp6bl941 158 9 at at IN cord-302530-pp6bl941 158 10 temperature temperature NN cord-302530-pp6bl941 158 11 T T NNP cord-302530-pp6bl941 158 12 ( ( -LRB- cord-302530-pp6bl941 158 13 calculated calculate VBN cord-302530-pp6bl941 158 14 as as IN cord-302530-pp6bl941 158 15 ΔS ΔS NNP cord-302530-pp6bl941 158 16 a_immob_T a_immob_t NN cord-302530-pp6bl941 158 17 = = NFP cord-302530-pp6bl941 158 18 ΔS ΔS NNP cord-302530-pp6bl941 158 19 a_immob_T0 a_immob_t0 NN cord-302530-pp6bl941 158 20 + + CC cord-302530-pp6bl941 158 21 ΔC δc NN cord-302530-pp6bl941 158 22 p p NNP cord-302530-pp6bl941 158 23 .ln(T .ln(T NNP cord-302530-pp6bl941 158 24 / / SYM cord-302530-pp6bl941 158 25 T T NNP cord-302530-pp6bl941 158 26 0 0 CD cord-302530-pp6bl941 158 27 ) ) -RRB- cord-302530-pp6bl941 158 28 ) ) -RRB- cord-302530-pp6bl941 158 29 would would MD cord-302530-pp6bl941 158 30 be be VB cord-302530-pp6bl941 158 31 unaffected unaffected JJ cord-302530-pp6bl941 158 32 by by IN cord-302530-pp6bl941 158 33 temperature temperature NN cord-302530-pp6bl941 158 34 and and CC cord-302530-pp6bl941 158 35 hence hence RB cord-302530-pp6bl941 158 36 constant constant JJ cord-302530-pp6bl941 158 37 as as IN cord-302530-pp6bl941 158 38 assumed assume VBN cord-302530-pp6bl941 158 39 in in IN cord-302530-pp6bl941 158 40 the the DT cord-302530-pp6bl941 158 41 models model NNS cord-302530-pp6bl941 158 42 here here RB cord-302530-pp6bl941 158 43 . . . cord-302530-pp6bl941 159 1 2.2.2 2.2.2 LS cord-302530-pp6bl941 159 2 . . . cord-302530-pp6bl941 160 1 The the DT cord-302530-pp6bl941 160 2 effect effect NN cord-302530-pp6bl941 160 3 of of IN cord-302530-pp6bl941 160 4 the the DT cord-302530-pp6bl941 160 5 magnitude magnitude NN cord-302530-pp6bl941 160 6 of of IN cord-302530-pp6bl941 160 7 ΔC ΔC NNP cord-302530-pp6bl941 160 8 p p NN cord-302530-pp6bl941 160 9 on on IN cord-302530-pp6bl941 160 10 virus virus NN cord-302530-pp6bl941 160 11 binding bind VBG cord-302530-pp6bl941 160 12 affinity affinity NN cord-302530-pp6bl941 160 13 at at IN cord-302530-pp6bl941 161 1 temperature temperature NN cord-302530-pp6bl941 161 2 T T NNP cord-302530-pp6bl941 161 3 Substituting substitute VBG cord-302530-pp6bl941 161 4 ΔH ΔH NNP cord-302530-pp6bl941 161 5 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 161 6 and and CC cord-302530-pp6bl941 161 7 ΔS ΔS NNP cord-302530-pp6bl941 161 8 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 161 9 from from IN cord-302530-pp6bl941 161 10 Eqs Eqs NNP cord-302530-pp6bl941 161 11 . . . cord-302530-pp6bl941 162 1 ( ( -LRB- cord-302530-pp6bl941 162 2 4 4 LS cord-302530-pp6bl941 162 3 ) ) -RRB- cord-302530-pp6bl941 162 4 and and CC cord-302530-pp6bl941 162 5 ( ( -LRB- cord-302530-pp6bl941 162 6 6 6 LS cord-302530-pp6bl941 162 7 ) ) -RRB- cord-302530-pp6bl941 162 8 respectively respectively RB cord-302530-pp6bl941 162 9 into into IN cord-302530-pp6bl941 162 10 Eq Eq NNP cord-302530-pp6bl941 162 11 . . . cord-302530-pp6bl941 163 1 ( ( -LRB- cord-302530-pp6bl941 163 2 10 10 CD cord-302530-pp6bl941 163 3 ) ) -RRB- cord-302530-pp6bl941 163 4 gives give VBZ cord-302530-pp6bl941 163 5 Eq Eq NNP cord-302530-pp6bl941 163 6 . . . cord-302530-pp6bl941 164 1 ( ( -LRB- cord-302530-pp6bl941 164 2 11 11 CD cord-302530-pp6bl941 164 3 ) ) -RRB- cord-302530-pp6bl941 164 4 from from IN cord-302530-pp6bl941 164 5 which which WDT cord-302530-pp6bl941 164 6 K K NNP cord-302530-pp6bl941 164 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 164 8 is be VBZ cord-302530-pp6bl941 164 9 calculated calculate VBN cord-302530-pp6bl941 164 10 according accord VBG cord-302530-pp6bl941 164 11 to to IN cord-302530-pp6bl941 164 12 Eq Eq NNP cord-302530-pp6bl941 164 13 . . . cord-302530-pp6bl941 165 1 ( ( -LRB- cord-302530-pp6bl941 165 2 12 12 CD cord-302530-pp6bl941 165 3 ) ) -RRB- cord-302530-pp6bl941 165 4 where where WRB cord-302530-pp6bl941 165 5 R r NN cord-302530-pp6bl941 165 6 is be VBZ cord-302530-pp6bl941 165 7 the the DT cord-302530-pp6bl941 165 8 ideal ideal JJ cord-302530-pp6bl941 165 9 gas gas NN cord-302530-pp6bl941 165 10 constant constant NN cord-302530-pp6bl941 165 11 . . . cord-302530-pp6bl941 166 1 Comparing compare VBG cord-302530-pp6bl941 166 2 the the DT cord-302530-pp6bl941 166 3 predicted predict VBN cord-302530-pp6bl941 166 4 effect effect NN cord-302530-pp6bl941 166 5 on on IN cord-302530-pp6bl941 166 6 K K NNP cord-302530-pp6bl941 166 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 166 8 of of IN cord-302530-pp6bl941 166 9 the the DT cord-302530-pp6bl941 166 10 magnitude magnitude NN cord-302530-pp6bl941 166 11 of of IN cord-302530-pp6bl941 166 12 ΔC ΔC NNP cord-302530-pp6bl941 166 13 p p NN cord-302530-pp6bl941 166 14 in in IN cord-302530-pp6bl941 166 15 Case Case NNP cord-302530-pp6bl941 166 16 studies study NNS cord-302530-pp6bl941 166 17 1 1 CD cord-302530-pp6bl941 166 18 , , , cord-302530-pp6bl941 166 19 2 2 CD cord-302530-pp6bl941 166 20 and and CC cord-302530-pp6bl941 166 21 3 3 CD cord-302530-pp6bl941 166 22 requires require VBZ cord-302530-pp6bl941 166 23 a a DT cord-302530-pp6bl941 166 24 reference reference NN cord-302530-pp6bl941 166 25 temperature temperature NN cord-302530-pp6bl941 166 26 , , , cord-302530-pp6bl941 166 27 T T NNP cord-302530-pp6bl941 166 28 0 0 CD cord-302530-pp6bl941 166 29 , , , cord-302530-pp6bl941 166 30 to to TO cord-302530-pp6bl941 166 31 be be VB cord-302530-pp6bl941 166 32 defined define VBN cord-302530-pp6bl941 166 33 at at IN cord-302530-pp6bl941 166 34 which which WDT cord-302530-pp6bl941 166 35 the the DT cord-302530-pp6bl941 166 36 plots plot NNS cord-302530-pp6bl941 166 37 of of IN cord-302530-pp6bl941 166 38 K K NNP cord-302530-pp6bl941 166 39 a_virus_T a_virus_T NNP cord-302530-pp6bl941 166 40 intercept intercept VB cord-302530-pp6bl941 166 41 . . . cord-302530-pp6bl941 167 1 Values value NNS cord-302530-pp6bl941 167 2 of of IN cord-302530-pp6bl941 167 3 K K NNP cord-302530-pp6bl941 167 4 a_virus_T a_virus_T NNP cord-302530-pp6bl941 167 5 intercept intercept VB cord-302530-pp6bl941 167 6 at at IN cord-302530-pp6bl941 167 7 T t NN cord-302530-pp6bl941 167 8 = = SYM cord-302530-pp6bl941 167 9 T t NN cord-302530-pp6bl941 167 10 0 0 NFP cord-302530-pp6bl941 167 11 because because IN cord-302530-pp6bl941 167 12 the the DT cord-302530-pp6bl941 167 13 n n NN cord-302530-pp6bl941 167 14 . . . cord-302530-pp6bl941 167 15 ΔC δc NN cord-302530-pp6bl941 167 16 p p NN cord-302530-pp6bl941 167 17 ( ( -LRB- cord-302530-pp6bl941 167 18 T T NNP cord-302530-pp6bl941 167 19 -T -t NN cord-302530-pp6bl941 167 20 0 0 NFP cord-302530-pp6bl941 168 1 + + CC cord-302530-pp6bl941 168 2 T.ln(T T.ln(T NNP cord-302530-pp6bl941 168 3 / / SYM cord-302530-pp6bl941 168 4 T T NNP cord-302530-pp6bl941 168 5 0 0 CD cord-302530-pp6bl941 168 6 ) ) -RRB- cord-302530-pp6bl941 168 7 ) ) -RRB- cord-302530-pp6bl941 168 8 term term NN cord-302530-pp6bl941 168 9 in in IN cord-302530-pp6bl941 168 10 Eq Eq NNP cord-302530-pp6bl941 168 11 . . . cord-302530-pp6bl941 169 1 ( ( -LRB- cord-302530-pp6bl941 169 2 11 11 CD cord-302530-pp6bl941 169 3 ) ) -RRB- cord-302530-pp6bl941 169 4 equals equal VBZ cord-302530-pp6bl941 169 5 zero zero CD cord-302530-pp6bl941 169 6 . . . cord-302530-pp6bl941 170 1 Therefore therefore RB cord-302530-pp6bl941 170 2 for for IN cord-302530-pp6bl941 170 3 the the DT cord-302530-pp6bl941 170 4 purpose purpose NN cord-302530-pp6bl941 170 5 of of IN cord-302530-pp6bl941 170 6 demonstrating demonstrate VBG cord-302530-pp6bl941 170 7 the the DT cord-302530-pp6bl941 170 8 effect effect NN cord-302530-pp6bl941 170 9 of of IN cord-302530-pp6bl941 170 10 ΔC ΔC NNP cord-302530-pp6bl941 170 11 p p NN cord-302530-pp6bl941 170 12 on on IN cord-302530-pp6bl941 170 13 the the DT cord-302530-pp6bl941 170 14 temperature temperature NN cord-302530-pp6bl941 170 15 sensitivity sensitivity NN cord-302530-pp6bl941 170 16 of of IN cord-302530-pp6bl941 170 17 K K NNP cord-302530-pp6bl941 170 18 a_virus_T a_virus_T NNP cord-302530-pp6bl941 170 19 , , , cord-302530-pp6bl941 170 20 T t NN cord-302530-pp6bl941 170 21 0 0 NFP cord-302530-pp6bl941 170 22 needs need VBZ cord-302530-pp6bl941 170 23 to to TO cord-302530-pp6bl941 170 24 be be VB cord-302530-pp6bl941 170 25 chosen choose VBN cord-302530-pp6bl941 170 26 to to TO cord-302530-pp6bl941 170 27 be be VB cord-302530-pp6bl941 170 28 well well RB cord-302530-pp6bl941 170 29 above above IN cord-302530-pp6bl941 170 30 or or CC cord-302530-pp6bl941 170 31 below below IN cord-302530-pp6bl941 170 32 the the DT cord-302530-pp6bl941 170 33 temperature temperature NN cord-302530-pp6bl941 170 34 range range NN cord-302530-pp6bl941 170 35 of of IN cord-302530-pp6bl941 170 36 interest interest NN cord-302530-pp6bl941 170 37 . . . cord-302530-pp6bl941 171 1 It -PRON- PRP cord-302530-pp6bl941 171 2 should should MD cord-302530-pp6bl941 171 3 be be VB cord-302530-pp6bl941 171 4 noted note VBN cord-302530-pp6bl941 171 5 that that IN cord-302530-pp6bl941 171 6 the the DT cord-302530-pp6bl941 171 7 choice choice NN cord-302530-pp6bl941 171 8 of of IN cord-302530-pp6bl941 171 9 reference reference NN cord-302530-pp6bl941 171 10 temperature temperature NN cord-302530-pp6bl941 171 11 is be VBZ cord-302530-pp6bl941 171 12 artificial artificial JJ cord-302530-pp6bl941 171 13 and and CC cord-302530-pp6bl941 171 14 is be VBZ cord-302530-pp6bl941 171 15 only only RB cord-302530-pp6bl941 171 16 used use VBN cord-302530-pp6bl941 171 17 here here RB cord-302530-pp6bl941 171 18 out out IN cord-302530-pp6bl941 171 19 of of IN cord-302530-pp6bl941 171 20 necessity necessity NN cord-302530-pp6bl941 171 21 to to TO cord-302530-pp6bl941 171 22 demonstrate demonstrate VB cord-302530-pp6bl941 171 23 the the DT cord-302530-pp6bl941 171 24 effect effect NN cord-302530-pp6bl941 171 25 of of IN cord-302530-pp6bl941 171 26 different different JJ cord-302530-pp6bl941 171 27 ΔC δc NN cord-302530-pp6bl941 171 28 p p NN cord-302530-pp6bl941 171 29 values value NNS cord-302530-pp6bl941 171 30 while while IN cord-302530-pp6bl941 171 31 fixing fix VBG cord-302530-pp6bl941 171 32 the the DT cord-302530-pp6bl941 171 33 K K NNP cord-302530-pp6bl941 171 34 a_virus_T a_virus_T NNP cord-302530-pp6bl941 171 35 intercept intercept VB cord-302530-pp6bl941 171 36 temperature temperature NN cord-302530-pp6bl941 171 37 . . . cord-302530-pp6bl941 172 1 Indeed indeed RB cord-302530-pp6bl941 172 2 a a DT cord-302530-pp6bl941 172 3 given give VBN cord-302530-pp6bl941 172 4 GP gp NN cord-302530-pp6bl941 172 5 / / SYM cord-302530-pp6bl941 172 6 Cr cr NN cord-302530-pp6bl941 172 7 system system NN cord-302530-pp6bl941 172 8 has have VBZ cord-302530-pp6bl941 172 9 its -PRON- PRP$ cord-302530-pp6bl941 172 10 own own JJ cord-302530-pp6bl941 172 11 natural natural JJ cord-302530-pp6bl941 172 12 ΔC ΔC NNP cord-302530-pp6bl941 172 13 p p NN cord-302530-pp6bl941 172 14 value value NN cord-302530-pp6bl941 172 15 which which WDT cord-302530-pp6bl941 172 16 can can MD cord-302530-pp6bl941 172 17 not not RB cord-302530-pp6bl941 172 18 be be VB cord-302530-pp6bl941 172 19 altered alter VBN cord-302530-pp6bl941 172 20 and and CC cord-302530-pp6bl941 172 21 is be VBZ cord-302530-pp6bl941 172 22 measured measure VBN cord-302530-pp6bl941 172 23 experimentally experimentally RB cord-302530-pp6bl941 173 1 ( ( -LRB- cord-302530-pp6bl941 173 2 Myszka Myszka NNP cord-302530-pp6bl941 173 3 et et NNP cord-302530-pp6bl941 173 4 al al NNP cord-302530-pp6bl941 173 5 . . NNP cord-302530-pp6bl941 173 6 , , , cord-302530-pp6bl941 173 7 2000 2000 CD cord-302530-pp6bl941 173 8 ; ; : cord-302530-pp6bl941 173 9 Fei Fei NNP cord-302530-pp6bl941 173 10 et et NNP cord-302530-pp6bl941 173 11 al al NNP cord-302530-pp6bl941 173 12 . . NNP cord-302530-pp6bl941 173 13 , , , cord-302530-pp6bl941 173 14 2015 2015 CD cord-302530-pp6bl941 173 15 ) ) -RRB- cord-302530-pp6bl941 173 16 . . . cord-302530-pp6bl941 174 1 The the DT cord-302530-pp6bl941 174 2 T t NN cord-302530-pp6bl941 174 3 0 0 CD cord-302530-pp6bl941 174 4 temperature temperature NN cord-302530-pp6bl941 174 5 of of IN cord-302530-pp6bl941 174 6 37 37 CD cord-302530-pp6bl941 174 7 ° ° NN cord-302530-pp6bl941 174 8 C C NNP cord-302530-pp6bl941 174 9 is be VBZ cord-302530-pp6bl941 174 10 appropriate appropriate JJ cord-302530-pp6bl941 174 11 to to TO cord-302530-pp6bl941 174 12 study study VB cord-302530-pp6bl941 174 13 arthropod arthropod JJ cord-302530-pp6bl941 174 14 vector vector NN cord-302530-pp6bl941 174 15 competence competence NN cord-302530-pp6bl941 174 16 for for IN cord-302530-pp6bl941 174 17 arbovirus arbovirus NN cord-302530-pp6bl941 174 18 transmission transmission NN cord-302530-pp6bl941 174 19 over over IN cord-302530-pp6bl941 174 20 the the DT cord-302530-pp6bl941 174 21 10 10 CD cord-302530-pp6bl941 174 22 to to TO cord-302530-pp6bl941 174 23 35 35 CD cord-302530-pp6bl941 174 24 ° ° NN cord-302530-pp6bl941 174 25 C c NN cord-302530-pp6bl941 174 26 temperature temperature NN cord-302530-pp6bl941 174 27 range range NN cord-302530-pp6bl941 174 28 in in IN cord-302530-pp6bl941 174 29 Case Case NNP cord-302530-pp6bl941 174 30 studies study NNS cord-302530-pp6bl941 174 31 1 1 CD cord-302530-pp6bl941 174 32 and and CC cord-302530-pp6bl941 174 33 2 2 CD cord-302530-pp6bl941 174 34 as as IN cord-302530-pp6bl941 174 35 used use VBN cord-302530-pp6bl941 174 36 previously previously RB cord-302530-pp6bl941 174 37 for for IN cord-302530-pp6bl941 174 38 the the DT cord-302530-pp6bl941 174 39 arthropod arthropod NNP cord-302530-pp6bl941 174 40 vector vector NN cord-302530-pp6bl941 174 41 competence competence NN cord-302530-pp6bl941 174 42 model model NN cord-302530-pp6bl941 174 43 ( ( -LRB- cord-302530-pp6bl941 174 44 Gale Gale NNP cord-302530-pp6bl941 174 45 2019 2019 CD cord-302530-pp6bl941 174 46 ) ) -RRB- cord-302530-pp6bl941 174 47 . . . cord-302530-pp6bl941 175 1 However however RB cord-302530-pp6bl941 175 2 , , , cord-302530-pp6bl941 175 3 since since IN cord-302530-pp6bl941 175 4 37 37 CD cord-302530-pp6bl941 175 5 ° ° NN cord-302530-pp6bl941 175 6 C C NNP cord-302530-pp6bl941 175 7 is be VBZ cord-302530-pp6bl941 175 8 the the DT cord-302530-pp6bl941 175 9 human human JJ cord-302530-pp6bl941 175 10 body body NN cord-302530-pp6bl941 175 11 temperature temperature NN cord-302530-pp6bl941 175 12 at at IN cord-302530-pp6bl941 175 13 which which WDT cord-302530-pp6bl941 175 14 HIV HIV NNP cord-302530-pp6bl941 175 15 binds bind VBZ cord-302530-pp6bl941 175 16 to to IN cord-302530-pp6bl941 175 17 host host NN cord-302530-pp6bl941 175 18 cells cell NNS cord-302530-pp6bl941 175 19 , , , cord-302530-pp6bl941 176 1 37 37 CD cord-302530-pp6bl941 176 2 ° ° NN cord-302530-pp6bl941 176 3 C c NN cord-302530-pp6bl941 176 4 is be VBZ cord-302530-pp6bl941 176 5 not not RB cord-302530-pp6bl941 176 6 a a DT cord-302530-pp6bl941 176 7 good good JJ cord-302530-pp6bl941 176 8 choice choice NN cord-302530-pp6bl941 176 9 for for IN cord-302530-pp6bl941 176 10 T t NN cord-302530-pp6bl941 176 11 0 0 CD cord-302530-pp6bl941 176 12 in in IN cord-302530-pp6bl941 176 13 case case NN cord-302530-pp6bl941 176 14 study study NN cord-302530-pp6bl941 176 15 3 3 CD cord-302530-pp6bl941 176 16 for for IN cord-302530-pp6bl941 176 17 which which WDT cord-302530-pp6bl941 176 18 T t NN cord-302530-pp6bl941 176 19 0 0 NFP cord-302530-pp6bl941 176 20 is be VBZ cord-302530-pp6bl941 176 21 therefore therefore RB cord-302530-pp6bl941 176 22 set set VBN cord-302530-pp6bl941 176 23 to to IN cord-302530-pp6bl941 176 24 4 4 CD cord-302530-pp6bl941 176 25 ° ° NN cord-302530-pp6bl941 176 26 C c NN cord-302530-pp6bl941 176 27 . . . cord-302530-pp6bl941 177 1 The the DT cord-302530-pp6bl941 177 2 reference reference NN cord-302530-pp6bl941 177 3 temperature temperature NN cord-302530-pp6bl941 177 4 is be VBZ cord-302530-pp6bl941 177 5 37 37 CD cord-302530-pp6bl941 177 6 ° ° NN cord-302530-pp6bl941 177 7 C c NN cord-302530-pp6bl941 177 8 in in IN cord-302530-pp6bl941 177 9 Case Case NNP cord-302530-pp6bl941 177 10 studies study NNS cord-302530-pp6bl941 177 11 4 4 CD cord-302530-pp6bl941 177 12 , , , cord-302530-pp6bl941 177 13 5 5 CD cord-302530-pp6bl941 177 14 and and CC cord-302530-pp6bl941 177 15 6 6 CD cord-302530-pp6bl941 177 16 because because IN cord-302530-pp6bl941 177 17 the the DT cord-302530-pp6bl941 177 18 experimentally experimentally RB cord-302530-pp6bl941 177 19 measured measure VBN cord-302530-pp6bl941 177 20 value value NN cord-302530-pp6bl941 177 21 of of IN cord-302530-pp6bl941 177 22 ΔC ΔC NNP cord-302530-pp6bl941 177 23 p p NNP cord-302530-pp6bl941 177 24 for for IN cord-302530-pp6bl941 177 25 HIV HIV NNP cord-302530-pp6bl941 178 1 gp120 gp120 NNP cord-302530-pp6bl941 178 2 : : : cord-302530-pp6bl941 178 3 CD4 CD4 NNP cord-302530-pp6bl941 178 4 binding bind VBG cord-302530-pp6bl941 178 5 ( ( -LRB- cord-302530-pp6bl941 178 6 Fig Fig NNP cord-302530-pp6bl941 178 7 . . . cord-302530-pp6bl941 178 8 1 1 CD cord-302530-pp6bl941 178 9 ) ) -RRB- cord-302530-pp6bl941 178 10 is be VBZ cord-302530-pp6bl941 178 11 used use VBN cord-302530-pp6bl941 178 12 together together RB cord-302530-pp6bl941 178 13 with with IN cord-302530-pp6bl941 178 14 ΔH ΔH NNP cord-302530-pp6bl941 178 15 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 178 16 and and CC cord-302530-pp6bl941 178 17 ΔS ΔS NNP cord-302530-pp6bl941 178 18 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 178 19 values value NNS cord-302530-pp6bl941 178 20 measured measure VBN cord-302530-pp6bl941 178 21 experimentally experimentally RB cord-302530-pp6bl941 178 22 at at IN cord-302530-pp6bl941 178 23 a a DT cord-302530-pp6bl941 178 24 temperature temperature NN cord-302530-pp6bl941 178 25 T t NN cord-302530-pp6bl941 178 26 0 0 CD cord-302530-pp6bl941 178 27 of of IN cord-302530-pp6bl941 178 28 37 37 CD cord-302530-pp6bl941 178 29 ° ° NN cord-302530-pp6bl941 178 30 C c NN cord-302530-pp6bl941 178 31 ( ( -LRB- cord-302530-pp6bl941 178 32 Myszka Myszka NNP cord-302530-pp6bl941 178 33 et et NNP cord-302530-pp6bl941 178 34 al al NNP cord-302530-pp6bl941 178 35 . . NNP cord-302530-pp6bl941 178 36 , , , cord-302530-pp6bl941 178 37 2000 2000 CD cord-302530-pp6bl941 178 38 ) ) -RRB- cord-302530-pp6bl941 178 39 , , , cord-302530-pp6bl941 178 40 i.e. i.e. FW cord-302530-pp6bl941 178 41 real real JJ cord-302530-pp6bl941 178 42 data datum NNS cord-302530-pp6bl941 178 43 are be VBP cord-302530-pp6bl941 178 44 used use VBN cord-302530-pp6bl941 178 45 . . . cord-302530-pp6bl941 179 1 2.3 2.3 CD cord-302530-pp6bl941 179 2 . . . cord-302530-pp6bl941 180 1 Case case NN cord-302530-pp6bl941 180 2 study study NN cord-302530-pp6bl941 180 3 1 1 CD cord-302530-pp6bl941 180 4 : : : cord-302530-pp6bl941 181 1 The the DT cord-302530-pp6bl941 181 2 predicted predict VBN cord-302530-pp6bl941 181 3 effect effect NN cord-302530-pp6bl941 181 4 of of IN cord-302530-pp6bl941 181 5 the the DT cord-302530-pp6bl941 181 6 magnitude magnitude NN cord-302530-pp6bl941 181 7 of of IN cord-302530-pp6bl941 181 8 ΔC ΔC NNP cord-302530-pp6bl941 181 9 p p NN cord-302530-pp6bl941 181 10 on on IN cord-302530-pp6bl941 181 11 the the DT cord-302530-pp6bl941 181 12 temperature temperature NN cord-302530-pp6bl941 181 13 dependence dependence NN cord-302530-pp6bl941 181 14 of of IN cord-302530-pp6bl941 181 15 DENV DENV NNP cord-302530-pp6bl941 181 16 transmission transmission NN cord-302530-pp6bl941 181 17 by by IN cord-302530-pp6bl941 181 18 Aedes Aedes NNP cord-302530-pp6bl941 181 19 albopictus albopictus NN cord-302530-pp6bl941 181 20 The the DT cord-302530-pp6bl941 181 21 approach approach NN cord-302530-pp6bl941 181 22 for for IN cord-302530-pp6bl941 181 23 modelling model VBG cord-302530-pp6bl941 181 24 arbovirus arbovirus NN cord-302530-pp6bl941 181 25 transmission transmission NN cord-302530-pp6bl941 181 26 efficiency efficiency NN cord-302530-pp6bl941 181 27 by by IN cord-302530-pp6bl941 181 28 the the DT cord-302530-pp6bl941 181 29 arthropod arthropod JJ cord-302530-pp6bl941 181 30 vector vector NN cord-302530-pp6bl941 181 31 has have VBZ cord-302530-pp6bl941 181 32 been be VBN cord-302530-pp6bl941 181 33 fully fully RB cord-302530-pp6bl941 181 34 described describe VBN cord-302530-pp6bl941 181 35 previously previously RB cord-302530-pp6bl941 181 36 ( ( -LRB- cord-302530-pp6bl941 181 37 Gale Gale NNP cord-302530-pp6bl941 181 38 2019 2019 CD cord-302530-pp6bl941 181 39 ) ) -RRB- cord-302530-pp6bl941 181 40 and and CC cord-302530-pp6bl941 181 41 is be VBZ cord-302530-pp6bl941 181 42 summarised summarise VBN cord-302530-pp6bl941 181 43 here here RB cord-302530-pp6bl941 181 44 for for IN cord-302530-pp6bl941 181 45 the the DT cord-302530-pp6bl941 181 46 purpose purpose NN cord-302530-pp6bl941 181 47 of of IN cord-302530-pp6bl941 181 48 the the DT cord-302530-pp6bl941 181 49 models model NNS cord-302530-pp6bl941 181 50 in in IN cord-302530-pp6bl941 181 51 Figs Figs NNPS cord-302530-pp6bl941 181 52 . . . cord-302530-pp6bl941 182 1 2 2 CD cord-302530-pp6bl941 182 2 and and CC cord-302530-pp6bl941 182 3 3 3 CD cord-302530-pp6bl941 182 4 . . . cord-302530-pp6bl941 183 1 The the DT cord-302530-pp6bl941 183 2 strength strength NN cord-302530-pp6bl941 183 3 of of IN cord-302530-pp6bl941 183 4 GP GP NNP cord-302530-pp6bl941 183 5 / / SYM cord-302530-pp6bl941 183 6 Cr cr NN cord-302530-pp6bl941 183 7 binding bind VBG cord-302530-pp6bl941 183 8 at at IN cord-302530-pp6bl941 183 9 temperature temperature NN cord-302530-pp6bl941 183 10 T t NN cord-302530-pp6bl941 183 11 is be VBZ cord-302530-pp6bl941 183 12 often often RB cord-302530-pp6bl941 183 13 expressed express VBN cord-302530-pp6bl941 183 14 as as IN cord-302530-pp6bl941 183 15 the the DT cord-302530-pp6bl941 183 16 dissociation dissociation NN cord-302530-pp6bl941 183 17 constant constant NN cord-302530-pp6bl941 183 18 , , , cord-302530-pp6bl941 183 19 K K NNP cord-302530-pp6bl941 183 20 d_receptor_T d_receptor_T NNP cord-302530-pp6bl941 183 21 , , , cord-302530-pp6bl941 183 22 for for IN cord-302530-pp6bl941 183 23 which which WDT cord-302530-pp6bl941 183 24 smaller small JJR cord-302530-pp6bl941 183 25 values value NNS cord-302530-pp6bl941 183 26 indicate indicate VBP cord-302530-pp6bl941 183 27 stronger strong JJR cord-302530-pp6bl941 183 28 binding bind VBG cord-302530-pp6bl941 183 29 ( ( -LRB- cord-302530-pp6bl941 184 1 Xiong Xiong NNP cord-302530-pp6bl941 184 2 et et NNP cord-302530-pp6bl941 184 3 al al NNP cord-302530-pp6bl941 184 4 . . NNP cord-302530-pp6bl941 184 5 , , , cord-302530-pp6bl941 184 6 2013 2013 CD cord-302530-pp6bl941 184 7 ) ) -RRB- cord-302530-pp6bl941 184 8 . . . cord-302530-pp6bl941 185 1 The the DT cord-302530-pp6bl941 185 2 thermodynamic thermodynamic JJ cord-302530-pp6bl941 185 3 model model NN cord-302530-pp6bl941 185 4 is be VBZ cord-302530-pp6bl941 185 5 based base VBN cord-302530-pp6bl941 185 6 on on IN cord-302530-pp6bl941 185 7 an an DT cord-302530-pp6bl941 185 8 enthalpy enthalpy NN cord-302530-pp6bl941 185 9 - - HYPH cord-302530-pp6bl941 185 10 driven drive VBN cord-302530-pp6bl941 185 11 GP GP NNP cord-302530-pp6bl941 185 12 / / SYM cord-302530-pp6bl941 185 13 Cr cr NN cord-302530-pp6bl941 185 14 interaction interaction NN cord-302530-pp6bl941 185 15 with with IN cord-302530-pp6bl941 185 16 a a DT cord-302530-pp6bl941 185 17 K K NNP cord-302530-pp6bl941 185 18 d_receptor_T0 d_receptor_t0 NN cord-302530-pp6bl941 185 19 of of IN cord-302530-pp6bl941 185 20 10 10 CD cord-302530-pp6bl941 185 21 −3 −3 NN cord-302530-pp6bl941 185 22 M M NNP cord-302530-pp6bl941 185 23 at at IN cord-302530-pp6bl941 185 24 37 37 CD cord-302530-pp6bl941 185 25 ° ° NN cord-302530-pp6bl941 185 26 C c NN cord-302530-pp6bl941 185 27 ( ( -LRB- cord-302530-pp6bl941 185 28 T T NNP cord-302530-pp6bl941 185 29 0 0 CD cord-302530-pp6bl941 185 30 ) ) -RRB- cord-302530-pp6bl941 185 31 as as IN cord-302530-pp6bl941 185 32 used use VBN cord-302530-pp6bl941 185 33 previously previously RB cord-302530-pp6bl941 185 34 ( ( -LRB- cord-302530-pp6bl941 185 35 Gale Gale NNP cord-302530-pp6bl941 185 36 2019 2019 CD cord-302530-pp6bl941 185 37 ) ) -RRB- cord-302530-pp6bl941 185 38 to to TO cord-302530-pp6bl941 185 39 represent represent VB cord-302530-pp6bl941 185 40 the the DT cord-302530-pp6bl941 185 41 interaction interaction NN cord-302530-pp6bl941 185 42 between between IN cord-302530-pp6bl941 185 43 an an DT cord-302530-pp6bl941 185 44 arbovirus arbovirus NN cord-302530-pp6bl941 185 45 GP gp NN cord-302530-pp6bl941 185 46 and and CC cord-302530-pp6bl941 185 47 a a DT cord-302530-pp6bl941 185 48 SA sa NN cord-302530-pp6bl941 185 49 glycan glycan NN cord-302530-pp6bl941 185 50 ( ( -LRB- cord-302530-pp6bl941 185 51 Cr Cr NNP cord-302530-pp6bl941 185 52 ) ) -RRB- cord-302530-pp6bl941 185 53 on on IN cord-302530-pp6bl941 185 54 the the DT cord-302530-pp6bl941 185 55 brush brush NN cord-302530-pp6bl941 185 56 border border NN cord-302530-pp6bl941 185 57 surface surface NN cord-302530-pp6bl941 185 58 of of IN cord-302530-pp6bl941 185 59 the the DT cord-302530-pp6bl941 185 60 epithelial epithelial JJ cord-302530-pp6bl941 185 61 cells cell NNS cord-302530-pp6bl941 185 62 lining line VBG cord-302530-pp6bl941 185 63 the the DT cord-302530-pp6bl941 185 64 arthropod arthropod NNP cord-302530-pp6bl941 185 65 midgut midgut NN cord-302530-pp6bl941 185 66 . . . cord-302530-pp6bl941 186 1 The the DT cord-302530-pp6bl941 186 2 parameters parameter NNS cord-302530-pp6bl941 186 3 ΔH ΔH NNP cord-302530-pp6bl941 186 4 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 186 5 and and CC cord-302530-pp6bl941 186 6 ΔS ΔS NNP cord-302530-pp6bl941 186 7 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 186 8 at at IN cord-302530-pp6bl941 186 9 T t NN cord-302530-pp6bl941 186 10 0 0 CD cord-302530-pp6bl941 186 11 = = NFP cord-302530-pp6bl941 187 1 37 37 CD cord-302530-pp6bl941 187 2 ° ° NN cord-302530-pp6bl941 187 3 C c NN cord-302530-pp6bl941 187 4 for for IN cord-302530-pp6bl941 187 5 DENV DENV NNP cord-302530-pp6bl941 187 6 transmission transmission NN cord-302530-pp6bl941 187 7 by by IN cord-302530-pp6bl941 187 8 Aedes Aedes NNP cord-302530-pp6bl941 187 9 albopictus albopictus NN cord-302530-pp6bl941 187 10 together together RB cord-302530-pp6bl941 187 11 with with IN cord-302530-pp6bl941 187 12 n n NN cord-302530-pp6bl941 187 13 and and CC cord-302530-pp6bl941 187 14 ΔS ΔS NNP cord-302530-pp6bl941 187 15 a_immob a_immob NNP cord-302530-pp6bl941 187 16 are be VBP cord-302530-pp6bl941 187 17 set set VBN cord-302530-pp6bl941 187 18 out out RP cord-302530-pp6bl941 187 19 in in IN cord-302530-pp6bl941 187 20 Table Table NNP cord-302530-pp6bl941 187 21 2 2 CD cord-302530-pp6bl941 187 22 and and CC cord-302530-pp6bl941 187 23 values value NNS cord-302530-pp6bl941 187 24 of of IN cord-302530-pp6bl941 187 25 K K NNP cord-302530-pp6bl941 187 26 a_virus_T a_virus_T NNP cord-302530-pp6bl941 187 27 over over IN cord-302530-pp6bl941 187 28 the the DT cord-302530-pp6bl941 187 29 temperature temperature NN cord-302530-pp6bl941 187 30 range range NN cord-302530-pp6bl941 187 31 10 10 CD cord-302530-pp6bl941 187 32 - - SYM cord-302530-pp6bl941 187 33 37 37 CD cord-302530-pp6bl941 187 34 ° ° NN cord-302530-pp6bl941 187 35 C c NN cord-302530-pp6bl941 187 36 are be VBP cord-302530-pp6bl941 187 37 calculated calculate VBN cord-302530-pp6bl941 187 38 for for IN cord-302530-pp6bl941 187 39 the the DT cord-302530-pp6bl941 187 40 ΔC ΔC NNP cord-302530-pp6bl941 187 41 p p NN cord-302530-pp6bl941 187 42 values value NNS cord-302530-pp6bl941 187 43 in in IN cord-302530-pp6bl941 187 44 Table table NN cord-302530-pp6bl941 187 45 3 3 CD cord-302530-pp6bl941 187 46 using use VBG cord-302530-pp6bl941 187 47 ΔG ΔG NNP cord-302530-pp6bl941 187 48 a_virus_T a_virus_T NNP cord-302530-pp6bl941 187 49 from from IN cord-302530-pp6bl941 187 50 Eq Eq NNP cord-302530-pp6bl941 187 51 . . . cord-302530-pp6bl941 188 1 ( ( -LRB- cord-302530-pp6bl941 188 2 11 11 CD cord-302530-pp6bl941 188 3 ) ) -RRB- cord-302530-pp6bl941 188 4 in in IN cord-302530-pp6bl941 188 5 Eq Eq NNP cord-302530-pp6bl941 188 6 . . . cord-302530-pp6bl941 189 1 ( ( -LRB- cord-302530-pp6bl941 189 2 12 12 CD cord-302530-pp6bl941 189 3 ) ) -RRB- cord-302530-pp6bl941 189 4 . . . cord-302530-pp6bl941 190 1 The the DT cord-302530-pp6bl941 190 2 arbovirus arbovirus NN cord-302530-pp6bl941 190 3 challenge challenge NN cord-302530-pp6bl941 190 4 dose dose NN cord-302530-pp6bl941 190 5 is be VBZ cord-302530-pp6bl941 191 1 10 10 CD cord-302530-pp6bl941 191 2 5 5 CD cord-302530-pp6bl941 191 3 virions virion NNS cord-302530-pp6bl941 191 4 and and CC cord-302530-pp6bl941 191 5 the the DT cord-302530-pp6bl941 191 6 midgut midgut NN cord-302530-pp6bl941 191 7 volume volume NN cord-302530-pp6bl941 191 8 is be VBZ cord-302530-pp6bl941 191 9 10 10 CD cord-302530-pp6bl941 191 10 −6 −6 NNP cord-302530-pp6bl941 191 11 dm dm NN cord-302530-pp6bl941 191 12 3 3 CD cord-302530-pp6bl941 191 13 giving give VBG cord-302530-pp6bl941 191 14 a a DT cord-302530-pp6bl941 191 15 virus virus NN cord-302530-pp6bl941 191 16 concentration concentration NN cord-302530-pp6bl941 191 17 [ [ -LRB- cord-302530-pp6bl941 191 18 V V NNP cord-302530-pp6bl941 191 19 total total NN cord-302530-pp6bl941 191 20 ] ] -RRB- cord-302530-pp6bl941 191 21 = = NFP cord-302530-pp6bl941 192 1 1.7 1.7 CD cord-302530-pp6bl941 192 2 × × CD cord-302530-pp6bl941 192 3 10 10 CD cord-302530-pp6bl941 192 4 −13 −13 NNP cord-302530-pp6bl941 192 5 M. M. NNP cord-302530-pp6bl941 193 1 The the DT cord-302530-pp6bl941 193 2 fraction fraction NN cord-302530-pp6bl941 193 3 ( ( -LRB- cord-302530-pp6bl941 193 4 F F NNP cord-302530-pp6bl941 193 5 cT cT NNP cord-302530-pp6bl941 193 6 ) ) -RRB- cord-302530-pp6bl941 193 7 of of IN cord-302530-pp6bl941 193 8 arthropod arthropod NNP cord-302530-pp6bl941 193 9 midgut midgut NN cord-302530-pp6bl941 193 10 cells cell NNS cord-302530-pp6bl941 193 11 with with IN cord-302530-pp6bl941 193 12 bound bind VBN cord-302530-pp6bl941 193 13 arbovirus arbovirus NN cord-302530-pp6bl941 193 14 at at IN cord-302530-pp6bl941 193 15 temperature temperature NN cord-302530-pp6bl941 193 16 T T NNP cord-302530-pp6bl941 193 17 is be VBZ cord-302530-pp6bl941 193 18 calculated calculate VBN cord-302530-pp6bl941 193 19 from from IN cord-302530-pp6bl941 193 20 K K NNP cord-302530-pp6bl941 193 21 a_virus_T a_virus_T NNP cord-302530-pp6bl941 193 22 using use VBG cord-302530-pp6bl941 193 23 Eq Eq NNP cord-302530-pp6bl941 193 24 . . . cord-302530-pp6bl941 194 1 ( ( -LRB- cord-302530-pp6bl941 194 2 13 13 CD cord-302530-pp6bl941 194 3 ) ) -RRB- cord-302530-pp6bl941 194 4 assuming assume VBG cord-302530-pp6bl941 194 5 the the DT cord-302530-pp6bl941 194 6 concentration concentration NN cord-302530-pp6bl941 194 7 of of IN cord-302530-pp6bl941 194 8 free free JJ cord-302530-pp6bl941 194 9 virus virus NN cord-302530-pp6bl941 194 10 ( ( -LRB- cord-302530-pp6bl941 194 11 [ [ -LRB- cord-302530-pp6bl941 194 12 V V NNP cord-302530-pp6bl941 194 13 free free JJ cord-302530-pp6bl941 194 14 ] ] -RRB- cord-302530-pp6bl941 194 15 ) ) -RRB- cord-302530-pp6bl941 195 1 ~[V ~[v CD cord-302530-pp6bl941 195 2 total total NN cord-302530-pp6bl941 195 3 ] ] -RRB- cord-302530-pp6bl941 195 4 . . . cord-302530-pp6bl941 196 1 The the DT cord-302530-pp6bl941 196 2 number number NN cord-302530-pp6bl941 196 3 , , , cord-302530-pp6bl941 196 4 C.V C.V NNP cord-302530-pp6bl941 196 5 T T NNP cord-302530-pp6bl941 196 6 , , , cord-302530-pp6bl941 196 7 of of IN cord-302530-pp6bl941 196 8 midgut midgut NN cord-302530-pp6bl941 196 9 cells cell NNS cord-302530-pp6bl941 196 10 with with IN cord-302530-pp6bl941 196 11 bound bind VBN cord-302530-pp6bl941 196 12 arbovirus arbovirus NN cord-302530-pp6bl941 196 13 at at IN cord-302530-pp6bl941 196 14 temperature temperature NN cord-302530-pp6bl941 196 15 T T NNP cord-302530-pp6bl941 196 16 is be VBZ cord-302530-pp6bl941 196 17 calculated calculate VBN cord-302530-pp6bl941 196 18 by by IN cord-302530-pp6bl941 196 19 multiplying multiply VBG cord-302530-pp6bl941 196 20 F F NNP cord-302530-pp6bl941 196 21 cT cT NNP cord-302530-pp6bl941 196 22 by by IN cord-302530-pp6bl941 196 23 the the DT cord-302530-pp6bl941 196 24 total total JJ cord-302530-pp6bl941 196 25 number number NN cord-302530-pp6bl941 196 26 of of IN cord-302530-pp6bl941 196 27 midgut midgut NN cord-302530-pp6bl941 196 28 cells cell NNS cord-302530-pp6bl941 196 29 ( ( -LRB- cord-302530-pp6bl941 196 30 C C NNP cord-302530-pp6bl941 196 31 total total NN cord-302530-pp6bl941 196 32 = = SYM cord-302530-pp6bl941 196 33 1000 1000 CD cord-302530-pp6bl941 196 34 ) ) -RRB- cord-302530-pp6bl941 197 1 ( ( -LRB- cord-302530-pp6bl941 197 2 Eq Eq NNP cord-302530-pp6bl941 197 3 . . . cord-302530-pp6bl941 198 1 ( ( -LRB- cord-302530-pp6bl941 198 2 14 14 CD cord-302530-pp6bl941 198 3 ) ) -RRB- cord-302530-pp6bl941 198 4 ) ) -RRB- cord-302530-pp6bl941 199 1 as as IN cord-302530-pp6bl941 199 2 described describe VBN cord-302530-pp6bl941 199 3 previously previously RB cord-302530-pp6bl941 199 4 ( ( -LRB- cord-302530-pp6bl941 199 5 Gale Gale NNP cord-302530-pp6bl941 199 6 2019 2019 CD cord-302530-pp6bl941 199 7 ) ) -RRB- cord-302530-pp6bl941 199 8 . . . cord-302530-pp6bl941 200 1 The the DT cord-302530-pp6bl941 200 2 probability probability NN cord-302530-pp6bl941 200 3 , , , cord-302530-pp6bl941 200 4 p p NNP cord-302530-pp6bl941 200 5 completeT completeT NNP cord-302530-pp6bl941 200 6 , , , cord-302530-pp6bl941 200 7 of of IN cord-302530-pp6bl941 200 8 an an DT cord-302530-pp6bl941 200 9 arthropod arthropod JJ cord-302530-pp6bl941 200 10 midgut midgut NN cord-302530-pp6bl941 200 11 cell cell NN cord-302530-pp6bl941 200 12 with with IN cord-302530-pp6bl941 200 13 bound bind VBN cord-302530-pp6bl941 200 14 virus virus NN cord-302530-pp6bl941 200 15 successfully successfully RB cord-302530-pp6bl941 200 16 leading lead VBG cord-302530-pp6bl941 200 17 to to IN cord-302530-pp6bl941 200 18 infection infection NN cord-302530-pp6bl941 200 19 of of IN cord-302530-pp6bl941 200 20 the the DT cord-302530-pp6bl941 200 21 arthropod arthropod JJ cord-302530-pp6bl941 200 22 salivary salivary NN cord-302530-pp6bl941 200 23 glands gland NNS cord-302530-pp6bl941 200 24 and and CC cord-302530-pp6bl941 200 25 completion completion NN cord-302530-pp6bl941 200 26 of of IN cord-302530-pp6bl941 200 27 virogenesis virogenesis NN cord-302530-pp6bl941 200 28 within within IN cord-302530-pp6bl941 200 29 in in IN cord-302530-pp6bl941 200 30 the the DT cord-302530-pp6bl941 200 31 lifetime lifetime NN cord-302530-pp6bl941 200 32 of of IN cord-302530-pp6bl941 200 33 the the DT cord-302530-pp6bl941 200 34 arthropod arthropod NNP cord-302530-pp6bl941 200 35 at at IN cord-302530-pp6bl941 200 36 temperature temperature NN cord-302530-pp6bl941 200 37 T T NNP cord-302530-pp6bl941 200 38 is be VBZ cord-302530-pp6bl941 200 39 calculated calculate VBN cord-302530-pp6bl941 200 40 using use VBG cord-302530-pp6bl941 200 41 the the DT cord-302530-pp6bl941 200 42 Arrhenius Arrhenius NNP cord-302530-pp6bl941 200 43 equation equation NN cord-302530-pp6bl941 200 44 ( ( -LRB- cord-302530-pp6bl941 200 45 Eq Eq NNP cord-302530-pp6bl941 200 46 . . . cord-302530-pp6bl941 201 1 ( ( -LRB- cord-302530-pp6bl941 201 2 15 15 CD cord-302530-pp6bl941 201 3 ) ) -RRB- cord-302530-pp6bl941 201 4 ) ) -RRB- cord-302530-pp6bl941 201 5 where where WRB cord-302530-pp6bl941 201 6 p p NN cord-302530-pp6bl941 201 7 complete283 complete283 NNP cord-302530-pp6bl941 201 8 is be VBZ cord-302530-pp6bl941 201 9 the the DT cord-302530-pp6bl941 201 10 probability probability NN cord-302530-pp6bl941 201 11 of of IN cord-302530-pp6bl941 201 12 this this DT cord-302530-pp6bl941 201 13 happening happen VBG cord-302530-pp6bl941 201 14 at at IN cord-302530-pp6bl941 201 15 10 10 CD cord-302530-pp6bl941 201 16 ° ° NN cord-302530-pp6bl941 201 17 C c NN cord-302530-pp6bl941 201 18 ( ( -LRB- cord-302530-pp6bl941 201 19 283 283 CD cord-302530-pp6bl941 201 20 K K NNP cord-302530-pp6bl941 201 21 ) ) -RRB- cord-302530-pp6bl941 201 22 and and CC cord-302530-pp6bl941 202 1 E E NNP cord-302530-pp6bl941 202 2 A A NNP cord-302530-pp6bl941 202 3 is be VBZ cord-302530-pp6bl941 202 4 the the DT cord-302530-pp6bl941 202 5 activation activation NN cord-302530-pp6bl941 202 6 energy energy NN cord-302530-pp6bl941 202 7 of of IN cord-302530-pp6bl941 202 8 the the DT cord-302530-pp6bl941 202 9 rate rate NN cord-302530-pp6bl941 202 10 - - HYPH cord-302530-pp6bl941 202 11 limiting limit VBG cord-302530-pp6bl941 202 12 step step NN cord-302530-pp6bl941 202 13 in in IN cord-302530-pp6bl941 202 14 virogenesis virogenesis NN cord-302530-pp6bl941 202 15 ( ( -LRB- cord-302530-pp6bl941 202 16 Table table NN cord-302530-pp6bl941 202 17 2 2 CD cord-302530-pp6bl941 202 18 ) ) -RRB- cord-302530-pp6bl941 202 19 . . . cord-302530-pp6bl941 203 1 The the DT cord-302530-pp6bl941 203 2 probability probability NN cord-302530-pp6bl941 203 3 , , , cord-302530-pp6bl941 203 4 p p NN cord-302530-pp6bl941 203 5 transmissionT transmissionT NNP cord-302530-pp6bl941 203 6 , , , cord-302530-pp6bl941 203 7 of of IN cord-302530-pp6bl941 203 8 arbovirus arbovirus NN cord-302530-pp6bl941 203 9 transmission transmission NN cord-302530-pp6bl941 203 10 by by IN cord-302530-pp6bl941 203 11 the the DT cord-302530-pp6bl941 203 12 arthropod arthropod NN cord-302530-pp6bl941 203 13 ( ( -LRB- cord-302530-pp6bl941 203 14 i.e. i.e. FW cord-302530-pp6bl941 203 15 successful successful JJ cord-302530-pp6bl941 203 16 infection infection NN cord-302530-pp6bl941 203 17 of of IN cord-302530-pp6bl941 203 18 the the DT cord-302530-pp6bl941 203 19 arthropod arthropod JJ cord-302530-pp6bl941 203 20 salivary salivary NN cord-302530-pp6bl941 203 21 glands gland NNS cord-302530-pp6bl941 203 22 after after IN cord-302530-pp6bl941 203 23 oral oral JJ cord-302530-pp6bl941 203 24 exposure exposure NN cord-302530-pp6bl941 203 25 ) ) -RRB- cord-302530-pp6bl941 203 26 at at IN cord-302530-pp6bl941 203 27 temperature temperature NN cord-302530-pp6bl941 203 28 T T NNP cord-302530-pp6bl941 203 29 given give VBN cord-302530-pp6bl941 203 30 C.V C.V NNP cord-302530-pp6bl941 203 31 T T NNP cord-302530-pp6bl941 203 32 midgut midgut NN cord-302530-pp6bl941 203 33 cells cell NNS cord-302530-pp6bl941 203 34 have have VBP cord-302530-pp6bl941 203 35 bound bind VBN cord-302530-pp6bl941 203 36 virus virus NN cord-302530-pp6bl941 203 37 is be VBZ cord-302530-pp6bl941 203 38 given give VBN cord-302530-pp6bl941 203 39 by by IN cord-302530-pp6bl941 203 40 Eq Eq NNP cord-302530-pp6bl941 203 41 . . . cord-302530-pp6bl941 204 1 ( ( -LRB- cord-302530-pp6bl941 204 2 16 16 CD cord-302530-pp6bl941 204 3 ) ) -RRB- cord-302530-pp6bl941 204 4 . . . cord-302530-pp6bl941 205 1 The the DT cord-302530-pp6bl941 205 2 magnitude magnitude NN cord-302530-pp6bl941 205 3 of of IN cord-302530-pp6bl941 205 4 ΔC ΔC NNP cord-302530-pp6bl941 205 5 p p NN cord-302530-pp6bl941 205 6 could could MD cord-302530-pp6bl941 205 7 explain explain VB cord-302530-pp6bl941 205 8 the the DT cord-302530-pp6bl941 205 9 temperature temperature NN cord-302530-pp6bl941 205 10 peak peak NN cord-302530-pp6bl941 205 11 observed observe VBN cord-302530-pp6bl941 205 12 in in IN cord-302530-pp6bl941 205 13 the the DT cord-302530-pp6bl941 205 14 specific specific JJ cord-302530-pp6bl941 205 15 binding binding NN cord-302530-pp6bl941 205 16 of of IN cord-302530-pp6bl941 205 17 WEEV WEEV NNP cord-302530-pp6bl941 205 18 to to TO cord-302530-pp6bl941 205 19 susceptible susceptible JJ cord-302530-pp6bl941 205 20 Culex Culex NNP cord-302530-pp6bl941 205 21 tarsalis tarsali NNS cord-302530-pp6bl941 205 22 BBFs BBFs . cord-302530-pp6bl941 206 1 The the DT cord-302530-pp6bl941 206 2 value value NN cord-302530-pp6bl941 206 3 of of IN cord-302530-pp6bl941 206 4 ΔC ΔC NNP cord-302530-pp6bl941 206 5 p p NN cord-302530-pp6bl941 206 6 in in IN cord-302530-pp6bl941 206 7 Eq Eq NNP cord-302530-pp6bl941 206 8 . . . cord-302530-pp6bl941 207 1 ( ( -LRB- cord-302530-pp6bl941 207 2 11 11 CD cord-302530-pp6bl941 207 3 ) ) -RRB- cord-302530-pp6bl941 207 4 with with IN cord-302530-pp6bl941 207 5 the the DT cord-302530-pp6bl941 207 6 GP GP NNP cord-302530-pp6bl941 207 7 / / SYM cord-302530-pp6bl941 207 8 Cr cr NN cord-302530-pp6bl941 207 9 binding binding NN cord-302530-pp6bl941 207 10 parameters parameter NNS cord-302530-pp6bl941 207 11 for for IN cord-302530-pp6bl941 207 12 DENV DENV NNP cord-302530-pp6bl941 207 13 in in IN cord-302530-pp6bl941 207 14 Table Table NNP cord-302530-pp6bl941 207 15 2 2 CD cord-302530-pp6bl941 207 16 was be VBD cord-302530-pp6bl941 207 17 optimised optimise VBN cord-302530-pp6bl941 207 18 so so IN cord-302530-pp6bl941 207 19 that that IN cord-302530-pp6bl941 207 20 C.V C.V NNP cord-302530-pp6bl941 207 21 T T NNP cord-302530-pp6bl941 207 22 as as IN cord-302530-pp6bl941 207 23 a a DT cord-302530-pp6bl941 207 24 function function NN cord-302530-pp6bl941 207 25 of of IN cord-302530-pp6bl941 207 26 temperature temperature NN cord-302530-pp6bl941 207 27 best best RB cord-302530-pp6bl941 207 28 approximated approximate VBD cord-302530-pp6bl941 207 29 the the DT cord-302530-pp6bl941 207 30 specific specific JJ cord-302530-pp6bl941 207 31 binding bind VBG cord-302530-pp6bl941 207 32 affinity affinity NN cord-302530-pp6bl941 207 33 of of IN cord-302530-pp6bl941 207 34 WEEV WEEV NNP cord-302530-pp6bl941 207 35 to to IN cord-302530-pp6bl941 207 36 BBFs bbf NNS cord-302530-pp6bl941 207 37 from from IN cord-302530-pp6bl941 207 38 susceptible susceptible JJ cord-302530-pp6bl941 207 39 Culex Culex NNP cord-302530-pp6bl941 207 40 tarsalis tarsalis NNPS cord-302530-pp6bl941 207 41 mosquitoes mosquito NNS cord-302530-pp6bl941 207 42 as as IN cord-302530-pp6bl941 207 43 determined determine VBN cord-302530-pp6bl941 207 44 by by IN cord-302530-pp6bl941 207 45 Houk Houk NNP cord-302530-pp6bl941 207 46 et et NNP cord-302530-pp6bl941 207 47 al al NNP cord-302530-pp6bl941 207 48 . . . cord-302530-pp6bl941 208 1 ( ( -LRB- cord-302530-pp6bl941 208 2 1990 1990 CD cord-302530-pp6bl941 208 3 ) ) -RRB- cord-302530-pp6bl941 209 1 and and CC cord-302530-pp6bl941 209 2 shown show VBN cord-302530-pp6bl941 209 3 in in IN cord-302530-pp6bl941 209 4 Fig Fig NNP cord-302530-pp6bl941 209 5 . . . cord-302530-pp6bl941 210 1 3 3 LS cord-302530-pp6bl941 210 2 . . . cord-302530-pp6bl941 211 1 2.5 2.5 CD cord-302530-pp6bl941 211 2 . . . cord-302530-pp6bl941 212 1 Case case NN cord-302530-pp6bl941 212 2 study study NN cord-302530-pp6bl941 212 3 3 3 CD cord-302530-pp6bl941 212 4 : : : cord-302530-pp6bl941 213 1 A a DT cord-302530-pp6bl941 213 2 large large JJ cord-302530-pp6bl941 213 3 negative negative JJ cord-302530-pp6bl941 213 4 ΔC δc NN cord-302530-pp6bl941 213 5 p p NN cord-302530-pp6bl941 213 6 for for IN cord-302530-pp6bl941 213 7 a a DT cord-302530-pp6bl941 213 8 protein protein NN cord-302530-pp6bl941 213 9 : : : cord-302530-pp6bl941 214 1 protein protein NN cord-302530-pp6bl941 214 2 GP GP NNP cord-302530-pp6bl941 214 3 / / SYM cord-302530-pp6bl941 214 4 Cr cr NN cord-302530-pp6bl941 214 5 system system NN cord-302530-pp6bl941 214 6 as as IN cord-302530-pp6bl941 214 7 represented represent VBN cord-302530-pp6bl941 214 8 by by IN cord-302530-pp6bl941 214 9 HIV HIV NNP cord-302530-pp6bl941 214 10 gp120 gp120 NNP cord-302530-pp6bl941 214 11 : : : cord-302530-pp6bl941 215 1 CD4 CD4 NNP cord-302530-pp6bl941 215 2 diminishes diminish VBZ cord-302530-pp6bl941 215 3 host host NN cord-302530-pp6bl941 215 4 cell cell NN cord-302530-pp6bl941 215 5 binding bind VBG cord-302530-pp6bl941 215 6 at at IN cord-302530-pp6bl941 215 7 higher high JJR cord-302530-pp6bl941 215 8 temperatures temperature NNS cord-302530-pp6bl941 215 9 2.5.1 2.5.1 CD cord-302530-pp6bl941 215 10 . . . cord-302530-pp6bl941 216 1 Estimation estimation NN cord-302530-pp6bl941 216 2 of of IN cord-302530-pp6bl941 216 3 n n NNP cord-302530-pp6bl941 216 4 for for IN cord-302530-pp6bl941 216 5 HIV HIV NNP cord-302530-pp6bl941 216 6 Yang Yang NNP cord-302530-pp6bl941 216 7 et et NNP cord-302530-pp6bl941 216 8 al al NNP cord-302530-pp6bl941 216 9 . . . cord-302530-pp6bl941 217 1 ( ( -LRB- cord-302530-pp6bl941 217 2 2005 2005 CD cord-302530-pp6bl941 217 3 ) ) -RRB- cord-302530-pp6bl941 217 4 using use VBG cord-302530-pp6bl941 217 5 defective defective JJ cord-302530-pp6bl941 217 6 HIV HIV NNP cord-302530-pp6bl941 217 7 gp120 gp120 NNP cord-302530-pp6bl941 217 8 monomers monomer NNS cord-302530-pp6bl941 217 9 concluded conclude VBD cord-302530-pp6bl941 217 10 that that IN cord-302530-pp6bl941 217 11 a a DT cord-302530-pp6bl941 217 12 single single JJ cord-302530-pp6bl941 217 13 Env Env NNP cord-302530-pp6bl941 217 14 trimer trimer NN cord-302530-pp6bl941 217 15 is be VBZ cord-302530-pp6bl941 217 16 sufficient sufficient JJ cord-302530-pp6bl941 217 17 to to TO cord-302530-pp6bl941 217 18 mediate mediate VB cord-302530-pp6bl941 217 19 the the DT cord-302530-pp6bl941 217 20 entry entry NN cord-302530-pp6bl941 217 21 of of IN cord-302530-pp6bl941 217 22 one one CD cord-302530-pp6bl941 217 23 virion virion NN cord-302530-pp6bl941 217 24 , , , cord-302530-pp6bl941 217 25 but but CC cord-302530-pp6bl941 217 26 that that IN cord-302530-pp6bl941 217 27 all all DT cord-302530-pp6bl941 217 28 three three CD cord-302530-pp6bl941 217 29 gp120 gp120 NNP cord-302530-pp6bl941 217 30 monomers monomer NNS cord-302530-pp6bl941 217 31 in in IN cord-302530-pp6bl941 217 32 that that DT cord-302530-pp6bl941 217 33 trimer trimer NN cord-302530-pp6bl941 217 34 must must MD cord-302530-pp6bl941 217 35 be be VB cord-302530-pp6bl941 217 36 active active JJ cord-302530-pp6bl941 217 37 . . . cord-302530-pp6bl941 218 1 Klasse Klasse NNP cord-302530-pp6bl941 218 2 ( ( -LRB- cord-302530-pp6bl941 218 3 2012 2012 CD cord-302530-pp6bl941 218 4 ) ) -RRB- cord-302530-pp6bl941 218 5 has have VBZ cord-302530-pp6bl941 218 6 proposed propose VBN cord-302530-pp6bl941 218 7 that that IN cord-302530-pp6bl941 218 8 a a DT cord-302530-pp6bl941 218 9 realistic realistic JJ cord-302530-pp6bl941 218 10 model model NN cord-302530-pp6bl941 218 11 allows allow VBZ cord-302530-pp6bl941 218 12 both both CC cord-302530-pp6bl941 218 13 a a DT cord-302530-pp6bl941 218 14 minimum minimum JJ cord-302530-pp6bl941 218 15 requirement requirement NN cord-302530-pp6bl941 218 16 of of IN cord-302530-pp6bl941 218 17 two two CD cord-302530-pp6bl941 218 18 gp120 gp120 NNP cord-302530-pp6bl941 218 19 monomers monomer NNS cord-302530-pp6bl941 218 20 with with IN cord-302530-pp6bl941 218 21 an an DT cord-302530-pp6bl941 218 22 increment increment NN cord-302530-pp6bl941 218 23 in in IN cord-302530-pp6bl941 218 24 function function NN cord-302530-pp6bl941 218 25 by by IN cord-302530-pp6bl941 218 26 the the DT cord-302530-pp6bl941 218 27 third third NN cord-302530-pp6bl941 218 28 . . . cord-302530-pp6bl941 219 1 This this DT cord-302530-pp6bl941 219 2 is be VBZ cord-302530-pp6bl941 219 3 consistent consistent JJ cord-302530-pp6bl941 219 4 with with IN cord-302530-pp6bl941 219 5 the the DT cord-302530-pp6bl941 219 6 cryo cryo NN cord-302530-pp6bl941 219 7 - - HYPH cord-302530-pp6bl941 219 8 electron electron NN cord-302530-pp6bl941 219 9 microscopy microscopy NN cord-302530-pp6bl941 219 10 ( ( -LRB- cord-302530-pp6bl941 219 11 EM EM NNP cord-302530-pp6bl941 219 12 ) ) -RRB- cord-302530-pp6bl941 219 13 structure structure NN cord-302530-pp6bl941 219 14 of of IN cord-302530-pp6bl941 219 15 the the DT cord-302530-pp6bl941 219 16 Env Env NNP cord-302530-pp6bl941 219 17 glycoprotein glycoprotein NN cord-302530-pp6bl941 219 18 trimer trimer NN cord-302530-pp6bl941 219 19 ( ( -LRB- cord-302530-pp6bl941 219 20 Liu Liu NNP cord-302530-pp6bl941 219 21 et et NNP cord-302530-pp6bl941 219 22 al al NNP cord-302530-pp6bl941 219 23 . . NNP cord-302530-pp6bl941 219 24 , , , cord-302530-pp6bl941 219 25 2017a 2017a CD cord-302530-pp6bl941 219 26 ) ) -RRB- cord-302530-pp6bl941 219 27 showing show VBG cord-302530-pp6bl941 219 28 that that IN cord-302530-pp6bl941 219 29 in in IN cord-302530-pp6bl941 219 30 each each DT cord-302530-pp6bl941 219 31 trimer trimer NN cord-302530-pp6bl941 219 32 , , , cord-302530-pp6bl941 219 33 one one CD cord-302530-pp6bl941 219 34 gp120 gp120 NN cord-302530-pp6bl941 219 35 monomer monomer NN cord-302530-pp6bl941 219 36 makes make VBZ cord-302530-pp6bl941 219 37 a a DT cord-302530-pp6bl941 219 38 primary primary JJ cord-302530-pp6bl941 219 39 contact contact NN cord-302530-pp6bl941 219 40 with with IN cord-302530-pp6bl941 219 41 the the DT cord-302530-pp6bl941 219 42 bound bind VBN cord-302530-pp6bl941 219 43 CD4 CD4 NNP cord-302530-pp6bl941 219 44 Cr Cr NNP cord-302530-pp6bl941 219 45 molecule molecule NN cord-302530-pp6bl941 219 46 while while IN cord-302530-pp6bl941 219 47 a a DT cord-302530-pp6bl941 219 48 second second NN cord-302530-pp6bl941 219 49 makes make VBZ cord-302530-pp6bl941 219 50 a a DT cord-302530-pp6bl941 219 51 partial partial JJ cord-302530-pp6bl941 219 52 ( ( -LRB- cord-302530-pp6bl941 219 53 Table table NN cord-302530-pp6bl941 219 54 3 3 CD cord-302530-pp6bl941 219 55 ) ) -RRB- cord-302530-pp6bl941 219 56 with with IN cord-302530-pp6bl941 219 57 model model NN cord-302530-pp6bl941 219 58 parameters parameter NNS cord-302530-pp6bl941 219 59 for for IN cord-302530-pp6bl941 219 60 arbovirus arbovirus NN cord-302530-pp6bl941 219 61 binding bind VBG cord-302530-pp6bl941 219 62 to to IN cord-302530-pp6bl941 219 63 mosquito mosquito NN cord-302530-pp6bl941 219 64 midgut midgut NN cord-302530-pp6bl941 219 65 cells cell NNS cord-302530-pp6bl941 219 66 in in IN cord-302530-pp6bl941 219 67 Table Table NNP cord-302530-pp6bl941 219 68 2 2 CD cord-302530-pp6bl941 219 69 and and CC cord-302530-pp6bl941 219 70 ΔS ΔS NNP cord-302530-pp6bl941 219 71 a_immob a_immob NNP cord-302530-pp6bl941 219 72 = = SYM cord-302530-pp6bl941 219 73 0 0 NFP cord-302530-pp6bl941 219 74 J/ J/ NNP cord-302530-pp6bl941 219 75 mol mol NNP cord-302530-pp6bl941 219 76 / / SYM cord-302530-pp6bl941 219 77 K. K. NNP cord-302530-pp6bl941 219 78 Experimental Experimental NNP cord-302530-pp6bl941 219 79 data datum NNS cord-302530-pp6bl941 219 80 ( ( -LRB- cord-302530-pp6bl941 219 81 ■ ■ NFP cord-302530-pp6bl941 219 82 ) ) -RRB- cord-302530-pp6bl941 219 83 in in IN cord-302530-pp6bl941 219 84 c c NNP cord-302530-pp6bl941 219 85 ) ) -RRB- cord-302530-pp6bl941 219 86 and and CC cord-302530-pp6bl941 219 87 d d LS cord-302530-pp6bl941 219 88 ) ) -RRB- cord-302530-pp6bl941 219 89 for for IN cord-302530-pp6bl941 219 90 DENV DENV NNP cord-302530-pp6bl941 219 91 transmission transmission NN cord-302530-pp6bl941 219 92 efficiency efficiency NN cord-302530-pp6bl941 219 93 by by IN cord-302530-pp6bl941 219 94 Aedes Aedes NNP cord-302530-pp6bl941 219 95 albopictus albopictus NN cord-302530-pp6bl941 219 96 mosquitoes mosquito NNS cord-302530-pp6bl941 219 97 from from IN cord-302530-pp6bl941 219 98 Liu Liu NNP cord-302530-pp6bl941 219 99 et et NNP cord-302530-pp6bl941 219 100 al al NNP cord-302530-pp6bl941 219 101 . . . cord-302530-pp6bl941 220 1 ( ( -LRB- cord-302530-pp6bl941 220 2 2017a 2017a CD cord-302530-pp6bl941 220 3 ) ) -RRB- cord-302530-pp6bl941 220 4 . . . cord-302530-pp6bl941 221 1 ( ( -LRB- cord-302530-pp6bl941 221 2 Table table NN cord-302530-pp6bl941 221 3 3 3 CD cord-302530-pp6bl941 221 4 ) ) -RRB- cord-302530-pp6bl941 221 5 with with IN cord-302530-pp6bl941 221 6 model model NN cord-302530-pp6bl941 221 7 parameters parameter NNS cord-302530-pp6bl941 221 8 for for IN cord-302530-pp6bl941 221 9 arbovirus arbovirus NN cord-302530-pp6bl941 221 10 binding bind VBG cord-302530-pp6bl941 221 11 to to IN cord-302530-pp6bl941 221 12 mosquito mosquito NN cord-302530-pp6bl941 221 13 midgut midgut NN cord-302530-pp6bl941 221 14 cells cell NNS cord-302530-pp6bl941 221 15 in in IN cord-302530-pp6bl941 221 16 Table Table NNP cord-302530-pp6bl941 221 17 2 2 CD cord-302530-pp6bl941 221 18 and and CC cord-302530-pp6bl941 221 19 ΔS ΔS NNP cord-302530-pp6bl941 221 20 a_immob a_immob NNP cord-302530-pp6bl941 221 21 = = SYM cord-302530-pp6bl941 221 22 0 0 CD cord-302530-pp6bl941 221 23 J J NNP cord-302530-pp6bl941 221 24 / / SYM cord-302530-pp6bl941 221 25 mol mol NNP cord-302530-pp6bl941 221 26 / / SYM cord-302530-pp6bl941 221 27 K. K. NNP cord-302530-pp6bl941 221 28 Experimental Experimental NNP cord-302530-pp6bl941 221 29 data datum NNS cord-302530-pp6bl941 221 30 ( ( -LRB- cord-302530-pp6bl941 221 31 ■ ■ NFP cord-302530-pp6bl941 221 32 ) ) -RRB- cord-302530-pp6bl941 221 33 in in IN cord-302530-pp6bl941 221 34 b b LS cord-302530-pp6bl941 221 35 ) ) -RRB- cord-302530-pp6bl941 221 36 show show VB cord-302530-pp6bl941 221 37 specific specific JJ cord-302530-pp6bl941 221 38 binding binding NN cord-302530-pp6bl941 221 39 ( ( -LRB- cord-302530-pp6bl941 221 40 as as IN cord-302530-pp6bl941 221 41 the the DT cord-302530-pp6bl941 221 42 percentage percentage NN cord-302530-pp6bl941 221 43 of of IN cord-302530-pp6bl941 221 44 total total JJ cord-302530-pp6bl941 221 45 virus virus NN cord-302530-pp6bl941 221 46 bound bind VBN cord-302530-pp6bl941 221 47 ) ) -RRB- cord-302530-pp6bl941 221 48 of of IN cord-302530-pp6bl941 221 49 Western western JJ cord-302530-pp6bl941 221 50 equine equine JJ cord-302530-pp6bl941 221 51 encephalitis encephalitis NN cord-302530-pp6bl941 221 52 virus virus NN cord-302530-pp6bl941 221 53 ( ( -LRB- cord-302530-pp6bl941 221 54 WEEV WEEV NNP cord-302530-pp6bl941 221 55 ) ) -RRB- cord-302530-pp6bl941 221 56 to to TO cord-302530-pp6bl941 221 57 brush brush VB cord-302530-pp6bl941 221 58 border border NN cord-302530-pp6bl941 221 59 fragments fragment NNS cord-302530-pp6bl941 221 60 from from IN cord-302530-pp6bl941 221 61 susceptible susceptible JJ cord-302530-pp6bl941 221 62 Culex Culex NNP cord-302530-pp6bl941 221 63 tarsalis tarsalis NNPS cord-302530-pp6bl941 221 64 mosquitoes mosquito NNS cord-302530-pp6bl941 221 65 as as IN cord-302530-pp6bl941 221 66 determined determine VBN cord-302530-pp6bl941 221 67 by by IN cord-302530-pp6bl941 221 68 Houk Houk NNP cord-302530-pp6bl941 221 69 et et NNP cord-302530-pp6bl941 221 70 al al NNP cord-302530-pp6bl941 221 71 . . . cord-302530-pp6bl941 222 1 ( ( -LRB- cord-302530-pp6bl941 222 2 1990 1990 CD cord-302530-pp6bl941 222 3 ) ) -RRB- cord-302530-pp6bl941 222 4 . . . cord-302530-pp6bl941 223 1 contact contact NN cord-302530-pp6bl941 223 2 ( ( -LRB- cord-302530-pp6bl941 223 3 called call VBN cord-302530-pp6bl941 223 4 the the DT cord-302530-pp6bl941 223 5 quaternary quaternary JJ cord-302530-pp6bl941 223 6 contact contact NN cord-302530-pp6bl941 223 7 reflecting reflect VBG cord-302530-pp6bl941 223 8 protein protein NN cord-302530-pp6bl941 223 9 structure structure NN cord-302530-pp6bl941 223 10 nomenclature nomenclature NN cord-302530-pp6bl941 223 11 ) ) -RRB- cord-302530-pp6bl941 223 12 and and CC cord-302530-pp6bl941 223 13 the the DT cord-302530-pp6bl941 223 14 third third JJ cord-302530-pp6bl941 223 15 gp120 gp120 NNP cord-302530-pp6bl941 223 16 monomer monomer NN cord-302530-pp6bl941 223 17 makes make VBZ cord-302530-pp6bl941 223 18 no no DT cord-302530-pp6bl941 223 19 direct direct JJ cord-302530-pp6bl941 223 20 contact contact NN cord-302530-pp6bl941 223 21 with with IN cord-302530-pp6bl941 223 22 the the DT cord-302530-pp6bl941 223 23 CD4 CD4 NNP cord-302530-pp6bl941 223 24 at at RB cord-302530-pp6bl941 223 25 all all RB cord-302530-pp6bl941 223 26 . . . cord-302530-pp6bl941 224 1 For for IN cord-302530-pp6bl941 224 2 the the DT cord-302530-pp6bl941 224 3 purpose purpose NN cord-302530-pp6bl941 224 4 of of IN cord-302530-pp6bl941 224 5 the the DT cord-302530-pp6bl941 224 6 model model NN cord-302530-pp6bl941 224 7 here here RB cord-302530-pp6bl941 224 8 , , , cord-302530-pp6bl941 224 9 n n NNP cord-302530-pp6bl941 224 10 represents represent VBZ cord-302530-pp6bl941 224 11 the the DT cord-302530-pp6bl941 224 12 number number NN cord-302530-pp6bl941 224 13 of of IN cord-302530-pp6bl941 224 14 Env Env NNP cord-302530-pp6bl941 224 15 trimers trimer NNS cord-302530-pp6bl941 224 16 on on IN cord-302530-pp6bl941 224 17 each each DT cord-302530-pp6bl941 224 18 HIV HIV NNP cord-302530-pp6bl941 224 19 virion virion NN cord-302530-pp6bl941 224 20 that that WDT cord-302530-pp6bl941 224 21 interact interact VBP cord-302530-pp6bl941 224 22 with with IN cord-302530-pp6bl941 224 23 a a DT cord-302530-pp6bl941 224 24 CD4 CD4 NNP cord-302530-pp6bl941 224 25 Cr Cr NNP cord-302530-pp6bl941 224 26 during during IN cord-302530-pp6bl941 224 27 binding bind VBG cord-302530-pp6bl941 224 28 . . . cord-302530-pp6bl941 225 1 Brandenberg Brandenberg NNP cord-302530-pp6bl941 225 2 et et FW cord-302530-pp6bl941 225 3 al al NNP cord-302530-pp6bl941 225 4 . . . cord-302530-pp6bl941 226 1 ( ( -LRB- cord-302530-pp6bl941 226 2 2015 2015 CD cord-302530-pp6bl941 226 3 ) ) -RRB- cord-302530-pp6bl941 226 4 demonstrate demonstrate VBP cord-302530-pp6bl941 226 5 that that IN cord-302530-pp6bl941 226 6 divergent divergent JJ cord-302530-pp6bl941 226 7 HIV HIV NNP cord-302530-pp6bl941 226 8 strains strain NNS cord-302530-pp6bl941 226 9 differ differ VBP cord-302530-pp6bl941 226 10 in in IN cord-302530-pp6bl941 226 11 their -PRON- PRP$ cord-302530-pp6bl941 226 12 stoichiometry stoichiometry NN cord-302530-pp6bl941 226 13 of of IN cord-302530-pp6bl941 226 14 entry entry NN cord-302530-pp6bl941 226 15 and and CC cord-302530-pp6bl941 226 16 require require VBP cord-302530-pp6bl941 226 17 between between IN cord-302530-pp6bl941 226 18 1 1 CD cord-302530-pp6bl941 226 19 and and CC cord-302530-pp6bl941 226 20 7 7 CD cord-302530-pp6bl941 226 21 Env env NN cord-302530-pp6bl941 226 22 trimers trimer NNS cord-302530-pp6bl941 226 23 , , , cord-302530-pp6bl941 226 24 with with IN cord-302530-pp6bl941 226 25 most most JJS cord-302530-pp6bl941 226 26 strains strain NNS cord-302530-pp6bl941 226 27 depending depend VBG cord-302530-pp6bl941 226 28 on on IN cord-302530-pp6bl941 226 29 2 2 CD cord-302530-pp6bl941 226 30 to to IN cord-302530-pp6bl941 226 31 3 3 CD cord-302530-pp6bl941 226 32 Env Env NNP cord-302530-pp6bl941 226 33 trimers trimer NNS cord-302530-pp6bl941 226 34 to to TO cord-302530-pp6bl941 226 35 complete complete VB cord-302530-pp6bl941 226 36 infection infection NN cord-302530-pp6bl941 226 37 . . . cord-302530-pp6bl941 227 1 Here here RB cord-302530-pp6bl941 227 2 it -PRON- PRP cord-302530-pp6bl941 227 3 is be VBZ cord-302530-pp6bl941 227 4 assumed assume VBN cord-302530-pp6bl941 227 5 that that IN cord-302530-pp6bl941 227 6 n n NN cord-302530-pp6bl941 227 7 = = SYM cord-302530-pp6bl941 227 8 3 3 CD cord-302530-pp6bl941 227 9 Env env NN cord-302530-pp6bl941 227 10 : : : cord-302530-pp6bl941 227 11 CD4 CD4 NNP cord-302530-pp6bl941 227 12 interactions interaction NNS cord-302530-pp6bl941 227 13 for for IN cord-302530-pp6bl941 227 14 HIV HIV NNP cord-302530-pp6bl941 227 15 binding bind VBG cord-302530-pp6bl941 227 16 although although IN cord-302530-pp6bl941 227 17 the the DT cord-302530-pp6bl941 227 18 results result NNS cord-302530-pp6bl941 227 19 of of IN cord-302530-pp6bl941 227 20 Brandenberg Brandenberg NNP cord-302530-pp6bl941 227 21 et et NNP cord-302530-pp6bl941 227 22 al al NNP cord-302530-pp6bl941 227 23 . . . cord-302530-pp6bl941 228 1 ( ( -LRB- cord-302530-pp6bl941 228 2 2015 2015 CD cord-302530-pp6bl941 228 3 ) ) -RRB- cord-302530-pp6bl941 228 4 do do VBP cord-302530-pp6bl941 228 5 not not RB cord-302530-pp6bl941 228 6 separate separate VB cord-302530-pp6bl941 228 7 cell cell NN cord-302530-pp6bl941 228 8 surface surface NN cord-302530-pp6bl941 228 9 binding bind VBG cord-302530-pp6bl941 228 10 itself -PRON- PRP cord-302530-pp6bl941 228 11 from from IN cord-302530-pp6bl941 228 12 the the DT cord-302530-pp6bl941 228 13 subsequent subsequent JJ cord-302530-pp6bl941 228 14 HIV HIV NNP cord-302530-pp6bl941 228 15 / / SYM cord-302530-pp6bl941 228 16 cell cell NN cord-302530-pp6bl941 228 17 fusion fusion NN cord-302530-pp6bl941 228 18 in in IN cord-302530-pp6bl941 228 19 the the DT cord-302530-pp6bl941 228 20 entry entry NN cord-302530-pp6bl941 228 21 process process NN cord-302530-pp6bl941 228 22 . . . cord-302530-pp6bl941 229 1 If if IN cord-302530-pp6bl941 229 2 it -PRON- PRP cord-302530-pp6bl941 229 3 is be VBZ cord-302530-pp6bl941 229 4 later later RB cord-302530-pp6bl941 229 5 found find VBN cord-302530-pp6bl941 229 6 that that IN cord-302530-pp6bl941 229 7 cell cell NN cord-302530-pp6bl941 229 8 surface surface NN cord-302530-pp6bl941 229 9 binding bind VBG cord-302530-pp6bl941 229 10 only only RB cord-302530-pp6bl941 229 11 requires require VBZ cord-302530-pp6bl941 229 12 one one CD cord-302530-pp6bl941 229 13 Env env NN cord-302530-pp6bl941 229 14 : : : cord-302530-pp6bl941 229 15 CD4 CD4 NNP cord-302530-pp6bl941 229 16 interaction interaction NN cord-302530-pp6bl941 229 17 for for IN cord-302530-pp6bl941 229 18 example example NN cord-302530-pp6bl941 229 19 , , , cord-302530-pp6bl941 229 20 while while IN cord-302530-pp6bl941 229 21 more more JJR cord-302530-pp6bl941 229 22 are be VBP cord-302530-pp6bl941 229 23 required require VBN cord-302530-pp6bl941 229 24 for for IN cord-302530-pp6bl941 229 25 the the DT cord-302530-pp6bl941 229 26 membrane membrane NN cord-302530-pp6bl941 229 27 fusion fusion NN cord-302530-pp6bl941 229 28 , , , cord-302530-pp6bl941 229 29 then then RB cord-302530-pp6bl941 229 30 the the DT cord-302530-pp6bl941 229 31 model model NN cord-302530-pp6bl941 229 32 here here RB cord-302530-pp6bl941 229 33 for for IN cord-302530-pp6bl941 229 34 C.V C.V NNP cord-302530-pp6bl941 229 35 T T NNP cord-302530-pp6bl941 229 36 should should MD cord-302530-pp6bl941 229 37 be be VB cord-302530-pp6bl941 229 38 reparameterised reparameterise VBN cord-302530-pp6bl941 229 39 with with IN cord-302530-pp6bl941 229 40 n n NN cord-302530-pp6bl941 229 41 = = SYM cord-302530-pp6bl941 229 42 1 1 CD cord-302530-pp6bl941 229 43 although although IN cord-302530-pp6bl941 229 44 the the DT cord-302530-pp6bl941 229 45 number number NN cord-302530-pp6bl941 229 46 of of IN cord-302530-pp6bl941 229 47 Env Env NNP cord-302530-pp6bl941 229 48 : : : cord-302530-pp6bl941 229 49 CCR5 ccr5 JJ cord-302530-pp6bl941 229 50 and and CC cord-302530-pp6bl941 229 51 nonspecific nonspecific JJ cord-302530-pp6bl941 229 52 Env Env NNP cord-302530-pp6bl941 229 53 interactions interaction NNS cord-302530-pp6bl941 229 54 with with IN cord-302530-pp6bl941 229 55 attachment attachment NN cord-302530-pp6bl941 229 56 factors factor NNS cord-302530-pp6bl941 229 57 ( ( -LRB- cord-302530-pp6bl941 229 58 see see VB cord-302530-pp6bl941 229 59 below below RB cord-302530-pp6bl941 229 60 ) ) -RRB- cord-302530-pp6bl941 229 61 should should MD cord-302530-pp6bl941 229 62 also also RB cord-302530-pp6bl941 229 63 be be VB cord-302530-pp6bl941 229 64 built build VBN cord-302530-pp6bl941 229 65 into into IN cord-302530-pp6bl941 229 66 the the DT cord-302530-pp6bl941 229 67 model model NN cord-302530-pp6bl941 229 68 . . . cord-302530-pp6bl941 230 1 It -PRON- PRP cord-302530-pp6bl941 230 2 should should MD cord-302530-pp6bl941 230 3 be be VB cord-302530-pp6bl941 230 4 noted note VBN cord-302530-pp6bl941 230 5 that that IN cord-302530-pp6bl941 230 6 as as IN cord-302530-pp6bl941 230 7 for for IN cord-302530-pp6bl941 230 8 the the DT cord-302530-pp6bl941 230 9 arbovirus arbovirus NN cord-302530-pp6bl941 230 10 model model NN cord-302530-pp6bl941 230 11 , , , cord-302530-pp6bl941 230 12 it -PRON- PRP cord-302530-pp6bl941 230 13 is be VBZ cord-302530-pp6bl941 230 14 assumed assume VBN cord-302530-pp6bl941 230 15 that that IN cord-302530-pp6bl941 230 16 the the DT cord-302530-pp6bl941 230 17 n n NN cord-302530-pp6bl941 230 18 = = SYM cord-302530-pp6bl941 230 19 3 3 CD cord-302530-pp6bl941 230 20 Env Env NNP cord-302530-pp6bl941 230 21 : : : cord-302530-pp6bl941 230 22 CD4 CD4 NNP cord-302530-pp6bl941 230 23 interactions interaction NNS cord-302530-pp6bl941 230 24 act act VBP cord-302530-pp6bl941 230 25 independently independently RB cord-302530-pp6bl941 230 26 and and CC cord-302530-pp6bl941 230 27 not not RB cord-302530-pp6bl941 230 28 co co VB cord-302530-pp6bl941 230 29 - - VBZ cord-302530-pp6bl941 230 30 operatively operatively RB cord-302530-pp6bl941 230 31 in in IN cord-302530-pp6bl941 230 32 binding bind VBG cord-302530-pp6bl941 230 33 . . . cord-302530-pp6bl941 231 1 This this DT cord-302530-pp6bl941 231 2 is be VBZ cord-302530-pp6bl941 231 3 reflected reflect VBN cord-302530-pp6bl941 231 4 in in IN cord-302530-pp6bl941 231 5 Eqs Eqs NNP cord-302530-pp6bl941 231 6 . . . cord-302530-pp6bl941 232 1 ( ( -LRB- cord-302530-pp6bl941 232 2 7 7 CD cord-302530-pp6bl941 232 3 ) ) -RRB- cord-302530-pp6bl941 232 4 and and CC cord-302530-pp6bl941 232 5 ( ( -LRB- cord-302530-pp6bl941 232 6 8) 8) NN cord-302530-pp6bl941 232 7 where where WRB cord-302530-pp6bl941 232 8 ΔH ΔH NNP cord-302530-pp6bl941 232 9 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 232 10 and and CC cord-302530-pp6bl941 232 11 ΔS ΔS NNP cord-302530-pp6bl941 232 12 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 232 13 act act NN cord-302530-pp6bl941 232 14 additively additively RB cord-302530-pp6bl941 232 15 . . . cord-302530-pp6bl941 233 1 The the DT cord-302530-pp6bl941 233 2 Env Env NNP cord-302530-pp6bl941 233 3 trimer trimer NN cord-302530-pp6bl941 233 4 binds bind VBZ cord-302530-pp6bl941 233 5 a a DT cord-302530-pp6bl941 233 6 single single JJ cord-302530-pp6bl941 233 7 soluble soluble JJ cord-302530-pp6bl941 233 8 CD4 CD4 NNP cord-302530-pp6bl941 233 9 with with IN cord-302530-pp6bl941 233 10 a a DT cord-302530-pp6bl941 233 11 K K NNP cord-302530-pp6bl941 233 12 d_receptor_T d_receptor_t CD cord-302530-pp6bl941 233 13 ( ( -LRB- cord-302530-pp6bl941 233 14 25 25 CD cord-302530-pp6bl941 233 15 ° ° NN cord-302530-pp6bl941 233 16 C C NNP cord-302530-pp6bl941 233 17 ) ) -RRB- cord-302530-pp6bl941 233 18 of of IN cord-302530-pp6bl941 233 19 1.4 1.4 CD cord-302530-pp6bl941 233 20 × × NN cord-302530-pp6bl941 233 21 10 10 CD cord-302530-pp6bl941 233 22 −9 −9 NNP cord-302530-pp6bl941 233 23 M M NNP cord-302530-pp6bl941 233 24 ( ( -LRB- cord-302530-pp6bl941 233 25 Chuang Chuang NNP cord-302530-pp6bl941 233 26 et et NNP cord-302530-pp6bl941 233 27 al al NNP cord-302530-pp6bl941 233 28 . . NNP cord-302530-pp6bl941 233 29 , , , cord-302530-pp6bl941 233 30 2017 2017 CD cord-302530-pp6bl941 233 31 ) ) -RRB- cord-302530-pp6bl941 233 32 which which WDT cord-302530-pp6bl941 233 33 is be VBZ cord-302530-pp6bl941 233 34 15-fold 15-fold JJ cord-302530-pp6bl941 233 35 higher high JJR cord-302530-pp6bl941 233 36 than than IN cord-302530-pp6bl941 233 37 that that DT cord-302530-pp6bl941 233 38 for for IN cord-302530-pp6bl941 233 39 the the DT cord-302530-pp6bl941 233 40 gp120 gp120 NNP cord-302530-pp6bl941 233 41 monomer monomer NN cord-302530-pp6bl941 233 42 : : : cord-302530-pp6bl941 234 1 CD4 CD4 NNP cord-302530-pp6bl941 234 2 interaction interaction NN cord-302530-pp6bl941 234 3 estimated estimate VBN cord-302530-pp6bl941 234 4 at at IN cord-302530-pp6bl941 234 5 25 25 CD cord-302530-pp6bl941 234 6 ° ° NN cord-302530-pp6bl941 234 7 C c NN cord-302530-pp6bl941 234 8 from from IN cord-302530-pp6bl941 234 9 the the DT cord-302530-pp6bl941 234 10 data datum NNS cord-302530-pp6bl941 234 11 of of IN cord-302530-pp6bl941 234 12 Myszka Myszka NNP cord-302530-pp6bl941 234 13 et et NNP cord-302530-pp6bl941 234 14 al al NNP cord-302530-pp6bl941 234 15 . . . cord-302530-pp6bl941 235 1 ( ( -LRB- cord-302530-pp6bl941 235 2 2000 2000 CD cord-302530-pp6bl941 235 3 ) ) -RRB- cord-302530-pp6bl941 236 1 in in IN cord-302530-pp6bl941 236 2 Table Table NNP cord-302530-pp6bl941 236 3 4 4 CD cord-302530-pp6bl941 236 4 . . . cord-302530-pp6bl941 237 1 To to IN cord-302530-pp6bl941 237 2 the the DT cord-302530-pp6bl941 237 3 author author NN cord-302530-pp6bl941 237 4 's 's POS cord-302530-pp6bl941 237 5 knowledge knowledge NN cord-302530-pp6bl941 237 6 there there EX cord-302530-pp6bl941 237 7 are be VBP cord-302530-pp6bl941 237 8 no no DT cord-302530-pp6bl941 237 9 data data NN cord-302530-pp6bl941 237 10 for for IN cord-302530-pp6bl941 237 11 ΔH ΔH NNP cord-302530-pp6bl941 237 12 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 237 13 and and CC cord-302530-pp6bl941 237 14 ΔS ΔS NNP cord-302530-pp6bl941 237 15 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 237 16 for for IN cord-302530-pp6bl941 237 17 Env Env NNP cord-302530-pp6bl941 237 18 trimer trimer NN cord-302530-pp6bl941 237 19 binding bind VBG cord-302530-pp6bl941 237 20 to to IN cord-302530-pp6bl941 237 21 CD4 CD4 NNP cord-302530-pp6bl941 237 22 . . . cord-302530-pp6bl941 238 1 Therefore therefore RB cord-302530-pp6bl941 238 2 the the DT cord-302530-pp6bl941 238 3 values value NNS cord-302530-pp6bl941 238 4 for for IN cord-302530-pp6bl941 238 5 ΔH ΔH NNP cord-302530-pp6bl941 238 6 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 238 7 and and CC cord-302530-pp6bl941 238 8 ΔS ΔS NNP cord-302530-pp6bl941 238 9 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 238 10 for for IN cord-302530-pp6bl941 238 11 HIV HIV NNP cord-302530-pp6bl941 238 12 gp120 gp120 NNP cord-302530-pp6bl941 238 13 monomer monomer NN cord-302530-pp6bl941 238 14 : : : cord-302530-pp6bl941 238 15 CD4 CD4 NNP cord-302530-pp6bl941 238 16 binding bind VBG cord-302530-pp6bl941 238 17 at at IN cord-302530-pp6bl941 238 18 37 37 CD cord-302530-pp6bl941 238 19 ° ° NN cord-302530-pp6bl941 238 20 C c NN cord-302530-pp6bl941 238 21 from from IN cord-302530-pp6bl941 238 22 Myszka Myszka NNP cord-302530-pp6bl941 238 23 et et NNP cord-302530-pp6bl941 238 24 al al NNP cord-302530-pp6bl941 238 25 . . . cord-302530-pp6bl941 239 1 ( ( -LRB- cord-302530-pp6bl941 239 2 2000 2000 CD cord-302530-pp6bl941 239 3 ) ) -RRB- cord-302530-pp6bl941 239 4 are be VBP cord-302530-pp6bl941 239 5 used use VBN cord-302530-pp6bl941 239 6 for for IN cord-302530-pp6bl941 239 7 Env Env NNP cord-302530-pp6bl941 239 8 trimer trimer NN cord-302530-pp6bl941 239 9 binding bind VBG cord-302530-pp6bl941 239 10 to to IN cord-302530-pp6bl941 239 11 a a DT cord-302530-pp6bl941 239 12 single single JJ cord-302530-pp6bl941 239 13 CD4 CD4 NNP cord-302530-pp6bl941 239 14 in in IN cord-302530-pp6bl941 239 15 the the DT cord-302530-pp6bl941 239 16 HIV HIV NNP cord-302530-pp6bl941 239 17 model model NN cord-302530-pp6bl941 239 18 in in IN cord-302530-pp6bl941 239 19 Fig Fig NNP cord-302530-pp6bl941 239 20 . . . cord-302530-pp6bl941 239 21 4a 4a CD cord-302530-pp6bl941 239 22 and and CC cord-302530-pp6bl941 239 23 b b LS cord-302530-pp6bl941 239 24 as as RB cord-302530-pp6bl941 239 25 set set VBN cord-302530-pp6bl941 239 26 out out RP cord-302530-pp6bl941 239 27 in in IN cord-302530-pp6bl941 239 28 Table Table NNP cord-302530-pp6bl941 239 29 4 4 CD cord-302530-pp6bl941 239 30 . . . cord-302530-pp6bl941 240 1 Dey Dey NNP cord-302530-pp6bl941 240 2 et et NNP cord-302530-pp6bl941 240 3 al al NNP cord-302530-pp6bl941 240 4 . . . cord-302530-pp6bl941 241 1 ( ( -LRB- cord-302530-pp6bl941 241 2 2007 2007 CD cord-302530-pp6bl941 241 3 ) ) -RRB- cord-302530-pp6bl941 241 4 reported report VBD cord-302530-pp6bl941 241 5 values value NNS cord-302530-pp6bl941 241 6 at at IN cord-302530-pp6bl941 241 7 37 37 CD cord-302530-pp6bl941 241 8 ° ° NN cord-302530-pp6bl941 241 9 C c NN cord-302530-pp6bl941 241 10 of of IN cord-302530-pp6bl941 241 11 −287.9 −287.9 NNPS cord-302530-pp6bl941 241 12 kJ kJ NNP cord-302530-pp6bl941 241 13 / / SYM cord-302530-pp6bl941 241 14 mol mol NNP cord-302530-pp6bl941 241 15 and and CC cord-302530-pp6bl941 241 16 -786.9 -786.9 : cord-302530-pp6bl941 241 17 J J NNP cord-302530-pp6bl941 241 18 / / SYM cord-302530-pp6bl941 241 19 mol mol NNP cord-302530-pp6bl941 241 20 / / SYM cord-302530-pp6bl941 241 21 K K NNP cord-302530-pp6bl941 241 22 for for IN cord-302530-pp6bl941 241 23 ΔH ΔH NNP cord-302530-pp6bl941 241 24 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 241 25 and and CC cord-302530-pp6bl941 241 26 ΔS ΔS NNP cord-302530-pp6bl941 241 27 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 241 28 respectively respectively RB cord-302530-pp6bl941 241 29 for for IN cord-302530-pp6bl941 241 30 the the DT cord-302530-pp6bl941 241 31 wildtype wildtype JJ cord-302530-pp6bl941 241 32 HIV-1 HIV-1 NNP cord-302530-pp6bl941 241 33 YU2 yu2 NN cord-302530-pp6bl941 241 34 gp120 gp120 NNP cord-302530-pp6bl941 241 35 monomer monomer NN cord-302530-pp6bl941 241 36 binding bind VBG cord-302530-pp6bl941 241 37 to to IN cord-302530-pp6bl941 241 38 soluble soluble JJ cord-302530-pp6bl941 241 39 CD4 CD4 NNP cord-302530-pp6bl941 241 40 . . . cord-302530-pp6bl941 242 1 The the DT cord-302530-pp6bl941 242 2 more more RBR cord-302530-pp6bl941 242 3 negative negative JJ cord-302530-pp6bl941 242 4 ΔS ΔS NNP cord-302530-pp6bl941 242 5 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 242 6 value value NN cord-302530-pp6bl941 242 7 for for IN cord-302530-pp6bl941 242 8 gp120 gp120 NNP cord-302530-pp6bl941 242 9 monomer monomer NN cord-302530-pp6bl941 242 10 : : : cord-302530-pp6bl941 243 1 CD4 CD4 NNP cord-302530-pp6bl941 243 2 binding bind VBG cord-302530-pp6bl941 243 3 from from IN cord-302530-pp6bl941 243 4 Dey Dey NNP cord-302530-pp6bl941 243 5 et et FW cord-302530-pp6bl941 243 6 al al NNP cord-302530-pp6bl941 243 7 . . . cord-302530-pp6bl941 244 1 ( ( -LRB- cord-302530-pp6bl941 244 2 2007 2007 CD cord-302530-pp6bl941 244 3 ) ) -RRB- cord-302530-pp6bl941 244 4 reduces reduce VBZ cord-302530-pp6bl941 244 5 the the DT cord-302530-pp6bl941 244 6 binding bind VBG cord-302530-pp6bl941 244 7 affinity affinity NN cord-302530-pp6bl941 244 8 for for IN cord-302530-pp6bl941 244 9 gp120 gp120 NN cord-302530-pp6bl941 244 10 : : : cord-302530-pp6bl941 245 1 CD4 CD4 NNP cord-302530-pp6bl941 245 2 by by IN cord-302530-pp6bl941 245 3 nine nine CD cord-302530-pp6bl941 245 4 - - HYPH cord-302530-pp6bl941 245 5 fold fold NN cord-302530-pp6bl941 246 1 ( ( -LRB- cord-302530-pp6bl941 246 2 K K NNP cord-302530-pp6bl941 246 3 d_receptor_T d_receptor_t NN cord-302530-pp6bl941 246 4 = = SYM cord-302530-pp6bl941 246 5 4.2 4.2 CD cord-302530-pp6bl941 246 6 × × NN cord-302530-pp6bl941 246 7 10 10 CD cord-302530-pp6bl941 246 8 −8 −8 NNP cord-302530-pp6bl941 246 9 M M NNP cord-302530-pp6bl941 246 10 ) ) -RRB- cord-302530-pp6bl941 246 11 at at IN cord-302530-pp6bl941 246 12 37 37 CD cord-302530-pp6bl941 246 13 ° ° NN cord-302530-pp6bl941 246 14 C c NN cord-302530-pp6bl941 247 1 compared compare VBN cord-302530-pp6bl941 247 2 to to IN cord-302530-pp6bl941 247 3 that that DT cord-302530-pp6bl941 247 4 of of IN cord-302530-pp6bl941 247 5 4.75 4.75 CD cord-302530-pp6bl941 247 6 × × NN cord-302530-pp6bl941 247 7 10 10 CD cord-302530-pp6bl941 247 8 −9 −9 NNP cord-302530-pp6bl941 247 9 M M NNP cord-302530-pp6bl941 247 10 from from IN cord-302530-pp6bl941 247 11 Myszka Myszka NNP cord-302530-pp6bl941 247 12 et et NNP cord-302530-pp6bl941 247 13 al al NNP cord-302530-pp6bl941 247 14 . . . cord-302530-pp6bl941 248 1 ( ( -LRB- cord-302530-pp6bl941 248 2 2000 2000 CD cord-302530-pp6bl941 248 3 ) ) -RRB- cord-302530-pp6bl941 249 1 ( ( -LRB- cord-302530-pp6bl941 249 2 Table table NN cord-302530-pp6bl941 249 3 4 4 CD cord-302530-pp6bl941 249 4 ) ) -RRB- cord-302530-pp6bl941 249 5 . . . cord-302530-pp6bl941 250 1 This this DT cord-302530-pp6bl941 250 2 difference difference NN cord-302530-pp6bl941 250 3 may may MD cord-302530-pp6bl941 250 4 simply simply RB cord-302530-pp6bl941 250 5 reflect reflect VB cord-302530-pp6bl941 250 6 the the DT cord-302530-pp6bl941 250 7 different different JJ cord-302530-pp6bl941 250 8 strains strain NNS cord-302530-pp6bl941 250 9 of of IN cord-302530-pp6bl941 250 10 HIV-1 HIV-1 NNP cord-302530-pp6bl941 250 11 used use VBN cord-302530-pp6bl941 250 12 , , , cord-302530-pp6bl941 250 13 namely namely RB cord-302530-pp6bl941 250 14 YU2 YU2 NNP cord-302530-pp6bl941 250 15 by by IN cord-302530-pp6bl941 250 16 Dey Dey NNP cord-302530-pp6bl941 250 17 et et NNP cord-302530-pp6bl941 250 18 al al NNP cord-302530-pp6bl941 250 19 . . . cord-302530-pp6bl941 251 1 ( ( -LRB- cord-302530-pp6bl941 251 2 2007 2007 CD cord-302530-pp6bl941 251 3 ) ) -RRB- cord-302530-pp6bl941 252 1 and and CC cord-302530-pp6bl941 252 2 WD61 WD61 NNP cord-302530-pp6bl941 252 3 by by IN cord-302530-pp6bl941 252 4 Myszka Myszka NNP cord-302530-pp6bl941 252 5 et et NNP cord-302530-pp6bl941 252 6 al al NNP cord-302530-pp6bl941 252 7 . . . cord-302530-pp6bl941 253 1 ( ( -LRB- cord-302530-pp6bl941 253 2 2000 2000 CD cord-302530-pp6bl941 253 3 ) ) -RRB- cord-302530-pp6bl941 253 4 . . . cord-302530-pp6bl941 254 1 The the DT cord-302530-pp6bl941 254 2 HIV HIV NNP cord-302530-pp6bl941 254 3 gp120 gp120 NNP cord-302530-pp6bl941 254 4 monomer monomer NN cord-302530-pp6bl941 254 5 : : : cord-302530-pp6bl941 255 1 CD4 CD4 NNP cord-302530-pp6bl941 255 2 binding bind VBG cord-302530-pp6bl941 255 3 data datum NNS cord-302530-pp6bl941 255 4 of of IN cord-302530-pp6bl941 255 5 Myszka Myszka NNP cord-302530-pp6bl941 255 6 et et NNP cord-302530-pp6bl941 255 7 al al NNP cord-302530-pp6bl941 255 8 . . . cord-302530-pp6bl941 256 1 ( ( -LRB- cord-302530-pp6bl941 256 2 2000 2000 CD cord-302530-pp6bl941 256 3 ) ) -RRB- cord-302530-pp6bl941 256 4 are be VBP cord-302530-pp6bl941 256 5 chosen choose VBN cord-302530-pp6bl941 256 6 here here RB cord-302530-pp6bl941 256 7 over over IN cord-302530-pp6bl941 256 8 those those DT cord-302530-pp6bl941 256 9 of of IN cord-302530-pp6bl941 256 10 Dey Dey NNP cord-302530-pp6bl941 256 11 et et FW cord-302530-pp6bl941 256 12 al al NNP cord-302530-pp6bl941 256 13 . . . cord-302530-pp6bl941 257 1 ( ( -LRB- cord-302530-pp6bl941 257 2 2007 2007 CD cord-302530-pp6bl941 257 3 ) ) -RRB- cord-302530-pp6bl941 257 4 because because IN cord-302530-pp6bl941 257 5 Myszka Myszka NNP cord-302530-pp6bl941 257 6 et et NNP cord-302530-pp6bl941 257 7 al al NNP cord-302530-pp6bl941 257 8 . . . cord-302530-pp6bl941 258 1 ( ( -LRB- cord-302530-pp6bl941 258 2 2000 2000 CD cord-302530-pp6bl941 258 3 ) ) -RRB- cord-302530-pp6bl941 258 4 present present VBP cord-302530-pp6bl941 258 5 the the DT cord-302530-pp6bl941 258 6 variation variation NN cord-302530-pp6bl941 258 7 in in IN cord-302530-pp6bl941 258 8 ΔH ΔH NNP cord-302530-pp6bl941 258 9 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 258 10 with with IN cord-302530-pp6bl941 258 11 temperature temperature NN cord-302530-pp6bl941 258 12 as as IN cord-302530-pp6bl941 258 13 shown show VBN cord-302530-pp6bl941 258 14 in in IN cord-302530-pp6bl941 258 15 Fig Fig NNP cord-302530-pp6bl941 258 16 . . . cord-302530-pp6bl941 259 1 1 1 LS cord-302530-pp6bl941 259 2 together together RB cord-302530-pp6bl941 259 3 with with IN cord-302530-pp6bl941 259 4 information information NN cord-302530-pp6bl941 259 5 on on IN cord-302530-pp6bl941 259 6 ΔC ΔC NNP cord-302530-pp6bl941 259 7 p p NN cord-302530-pp6bl941 259 8 which which WDT cord-302530-pp6bl941 259 9 Dey Dey NNP cord-302530-pp6bl941 259 10 et et NNP cord-302530-pp6bl941 259 11 al al NNP cord-302530-pp6bl941 259 12 . . . cord-302530-pp6bl941 260 1 ( ( -LRB- cord-302530-pp6bl941 260 2 2007 2007 CD cord-302530-pp6bl941 260 3 ) ) -RRB- cord-302530-pp6bl941 260 4 do do VBP cord-302530-pp6bl941 260 5 not not RB cord-302530-pp6bl941 260 6 consider consider VB cord-302530-pp6bl941 260 7 . . . cord-302530-pp6bl941 261 1 It -PRON- PRP cord-302530-pp6bl941 261 2 is be VBZ cord-302530-pp6bl941 261 3 therefore therefore RB cord-302530-pp6bl941 261 4 assumed assume VBN cord-302530-pp6bl941 261 5 here here RB cord-302530-pp6bl941 261 6 that that DT cord-302530-pp6bl941 261 7 ΔC δc NN cord-302530-pp6bl941 261 8 p p NN cord-302530-pp6bl941 261 9 = = NN cord-302530-pp6bl941 261 10 −5.02 −5.02 NNP cord-302530-pp6bl941 261 11 kJ kJ NNP cord-302530-pp6bl941 261 12 / / SYM cord-302530-pp6bl941 261 13 mol mol NNP cord-302530-pp6bl941 261 14 / / SYM cord-302530-pp6bl941 261 15 K K NNP cord-302530-pp6bl941 261 16 for for IN cord-302530-pp6bl941 261 17 the the DT cord-302530-pp6bl941 261 18 Env Env NNP cord-302530-pp6bl941 261 19 trimer trimer NN cord-302530-pp6bl941 261 20 : : : cord-302530-pp6bl941 261 21 CD4 CD4 NNP cord-302530-pp6bl941 261 22 interaction interaction NN cord-302530-pp6bl941 261 23 as as IN cord-302530-pp6bl941 261 24 reported report VBN cord-302530-pp6bl941 261 25 by by IN cord-302530-pp6bl941 261 26 Myszka Myszka NNP cord-302530-pp6bl941 261 27 et et NNP cord-302530-pp6bl941 261 28 al al NNP cord-302530-pp6bl941 261 29 . . . cord-302530-pp6bl941 262 1 ( ( -LRB- cord-302530-pp6bl941 262 2 2000 2000 CD cord-302530-pp6bl941 262 3 ) ) -RRB- cord-302530-pp6bl941 263 1 for for IN cord-302530-pp6bl941 263 2 the the DT cord-302530-pp6bl941 263 3 gp120 gp120 NNP cord-302530-pp6bl941 263 4 monomer monomer NN cord-302530-pp6bl941 263 5 : : : cord-302530-pp6bl941 263 6 CD4 CD4 NNP cord-302530-pp6bl941 263 7 interaction interaction NN cord-302530-pp6bl941 263 8 ( ( -LRB- cord-302530-pp6bl941 263 9 Table Table NNP cord-302530-pp6bl941 263 10 3 3 CD cord-302530-pp6bl941 263 11 ) ) -RRB- cord-302530-pp6bl941 263 12 . . . cord-302530-pp6bl941 264 1 Values value NNS cord-302530-pp6bl941 264 2 of of IN cord-302530-pp6bl941 264 3 ΔS ΔS NNP cord-302530-pp6bl941 264 4 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 264 5 are be VBP cord-302530-pp6bl941 264 6 not not RB cord-302530-pp6bl941 264 7 documented document VBN cord-302530-pp6bl941 264 8 by by IN cord-302530-pp6bl941 264 9 Myszka Myszka NNP cord-302530-pp6bl941 264 10 et et NNP cord-302530-pp6bl941 264 11 al al NNP cord-302530-pp6bl941 264 12 . . . cord-302530-pp6bl941 265 1 ( ( -LRB- cord-302530-pp6bl941 265 2 2000 2000 CD cord-302530-pp6bl941 265 3 ) ) -RRB- cord-302530-pp6bl941 265 4 other other JJ cord-302530-pp6bl941 265 5 than than IN cord-302530-pp6bl941 265 6 that that DT cord-302530-pp6bl941 265 7 at at IN cord-302530-pp6bl941 265 8 37 37 CD cord-302530-pp6bl941 265 9 ° ° NN cord-302530-pp6bl941 265 10 C c NN cord-302530-pp6bl941 265 11 ( ( -LRB- cord-302530-pp6bl941 265 12 Table Table NNP cord-302530-pp6bl941 265 13 4 4 CD cord-302530-pp6bl941 265 14 ) ) -RRB- cord-302530-pp6bl941 265 15 and and CC cord-302530-pp6bl941 265 16 values value NNS cord-302530-pp6bl941 265 17 at at IN cord-302530-pp6bl941 265 18 lower low JJR cord-302530-pp6bl941 265 19 temperatures temperature NNS cord-302530-pp6bl941 265 20 are be VBP cord-302530-pp6bl941 265 21 therefore therefore RB cord-302530-pp6bl941 265 22 calculated calculate VBN cord-302530-pp6bl941 265 23 from from IN cord-302530-pp6bl941 265 24 that that DT cord-302530-pp6bl941 265 25 at at IN cord-302530-pp6bl941 265 26 T t NN cord-302530-pp6bl941 265 27 0 0 CD cord-302530-pp6bl941 265 28 = = SYM cord-302530-pp6bl941 265 29 37 37 CD cord-302530-pp6bl941 265 30 ° ° NN cord-302530-pp6bl941 265 31 C c NN cord-302530-pp6bl941 265 32 according accord VBG cord-302530-pp6bl941 265 33 to to IN cord-302530-pp6bl941 265 34 Eq Eq NNP cord-302530-pp6bl941 265 35 . . . cord-302530-pp6bl941 266 1 ( ( -LRB- cord-302530-pp6bl941 266 2 6 6 LS cord-302530-pp6bl941 266 3 ) ) -RRB- cord-302530-pp6bl941 266 4 using use VBG cord-302530-pp6bl941 266 5 ΔC ΔC NNP cord-302530-pp6bl941 266 6 p p NN cord-302530-pp6bl941 266 7 = = NN cord-302530-pp6bl941 266 8 −5.02 −5.02 NNP cord-302530-pp6bl941 266 9 kJ kJ NNP cord-302530-pp6bl941 266 10 / / SYM cord-302530-pp6bl941 266 11 mol mol NNP cord-302530-pp6bl941 266 12 / / SYM cord-302530-pp6bl941 266 13 K K NNP cord-302530-pp6bl941 266 14 for for IN cord-302530-pp6bl941 266 15 HIV HIV NNP cord-302530-pp6bl941 267 1 gp120 gp120 NNP cord-302530-pp6bl941 267 2 : : : cord-302530-pp6bl941 268 1 CD4 CD4 NNP cord-302530-pp6bl941 268 2 ( ( -LRB- cord-302530-pp6bl941 268 3 Table Table NNP cord-302530-pp6bl941 268 4 3 3 CD cord-302530-pp6bl941 268 5 ) ) -RRB- cord-302530-pp6bl941 268 6 . . . cord-302530-pp6bl941 269 1 Some some DT cord-302530-pp6bl941 269 2 reassurance reassurance NN cord-302530-pp6bl941 269 3 that that IN cord-302530-pp6bl941 269 4 Eq Eq NNP cord-302530-pp6bl941 269 5 . . . cord-302530-pp6bl941 270 1 ( ( -LRB- cord-302530-pp6bl941 270 2 6 6 LS cord-302530-pp6bl941 270 3 ) ) -RRB- cord-302530-pp6bl941 270 4 is be VBZ cord-302530-pp6bl941 270 5 appropriate appropriate JJ cord-302530-pp6bl941 270 6 is be VBZ cord-302530-pp6bl941 270 7 that that IN cord-302530-pp6bl941 270 8 the the DT cord-302530-pp6bl941 270 9 value value NN cord-302530-pp6bl941 270 10 of of IN cord-302530-pp6bl941 270 11 ΔS ΔS NNP cord-302530-pp6bl941 270 12 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 270 13 of of IN cord-302530-pp6bl941 270 14 −493 −493 NNP cord-302530-pp6bl941 270 15 J J NNP cord-302530-pp6bl941 270 16 / / SYM cord-302530-pp6bl941 270 17 mol mol NNP cord-302530-pp6bl941 270 18 / / SYM cord-302530-pp6bl941 270 19 K K NNP cord-302530-pp6bl941 270 20 predicted predict VBD cord-302530-pp6bl941 270 21 at at IN cord-302530-pp6bl941 270 22 T T NNP cord-302530-pp6bl941 270 23 = = SYM cord-302530-pp6bl941 270 24 25 25 CD cord-302530-pp6bl941 270 25 ° ° NN cord-302530-pp6bl941 270 26 C c NN cord-302530-pp6bl941 270 27 by by IN cord-302530-pp6bl941 270 28 Eq Eq NNP cord-302530-pp6bl941 270 29 . . . cord-302530-pp6bl941 271 1 ( ( -LRB- cord-302530-pp6bl941 271 2 6 6 LS cord-302530-pp6bl941 271 3 ) ) -RRB- cord-302530-pp6bl941 271 4 is be VBZ cord-302530-pp6bl941 271 5 very very RB cord-302530-pp6bl941 271 6 close close JJ cord-302530-pp6bl941 271 7 to to IN cord-302530-pp6bl941 271 8 that that DT cord-302530-pp6bl941 271 9 of of IN cord-302530-pp6bl941 271 10 −473 −473 NNP cord-302530-pp6bl941 271 11 J J NNP cord-302530-pp6bl941 271 12 / / SYM cord-302530-pp6bl941 271 13 mol mol NNP cord-302530-pp6bl941 271 14 / / SYM cord-302530-pp6bl941 271 15 K K NNP cord-302530-pp6bl941 271 16 calculated calculate VBD cord-302530-pp6bl941 271 17 from from IN cord-302530-pp6bl941 271 18 the the DT cord-302530-pp6bl941 271 19 -T. -t. JJ cord-302530-pp6bl941 271 20 ΔS ΔS NNP cord-302530-pp6bl941 271 21 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 271 22 value value NN cord-302530-pp6bl941 271 23 reported report VBN cord-302530-pp6bl941 271 24 by by IN cord-302530-pp6bl941 271 25 Myszka Myszka NNP cord-302530-pp6bl941 271 26 et et NNP cord-302530-pp6bl941 271 27 al al NNP cord-302530-pp6bl941 271 28 . . . cord-302530-pp6bl941 272 1 ( ( -LRB- cord-302530-pp6bl941 272 2 2000 2000 CD cord-302530-pp6bl941 272 3 ) ) -RRB- cord-302530-pp6bl941 272 4 at at IN cord-302530-pp6bl941 272 5 25 25 CD cord-302530-pp6bl941 272 6 ° ° NN cord-302530-pp6bl941 272 7 C c NN cord-302530-pp6bl941 272 8 ( ( -LRB- cord-302530-pp6bl941 272 9 Table Table NNP cord-302530-pp6bl941 272 10 4 4 CD cord-302530-pp6bl941 272 11 ) ) -RRB- cord-302530-pp6bl941 272 12 . . . cord-302530-pp6bl941 273 1 Predicted predict VBN cord-302530-pp6bl941 273 2 values value NNS cord-302530-pp6bl941 273 3 for for IN cord-302530-pp6bl941 273 4 ΔH ΔH NNP cord-302530-pp6bl941 273 5 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 273 6 and and CC cord-302530-pp6bl941 273 7 ΔS ΔS NNP cord-302530-pp6bl941 273 8 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 273 9 for for IN cord-302530-pp6bl941 273 10 HIV HIV NNP cord-302530-pp6bl941 273 11 Env Env NNP cord-302530-pp6bl941 273 12 : : : cord-302530-pp6bl941 274 1 CD4 CD4 NNP cord-302530-pp6bl941 274 2 binding bind VBG cord-302530-pp6bl941 274 3 at at IN cord-302530-pp6bl941 274 4 4 4 CD cord-302530-pp6bl941 274 5 ° ° NN cord-302530-pp6bl941 274 6 C C NNP cord-302530-pp6bl941 274 7 are be VBP cord-302530-pp6bl941 274 8 set set VBN cord-302530-pp6bl941 274 9 out out RP cord-302530-pp6bl941 274 10 in in IN cord-302530-pp6bl941 274 11 Table Table NNP cord-302530-pp6bl941 274 12 4 4 CD cord-302530-pp6bl941 274 13 and and CC cord-302530-pp6bl941 274 14 are be VBP cord-302530-pp6bl941 274 15 used use VBN cord-302530-pp6bl941 274 16 as as IN cord-302530-pp6bl941 274 17 ΔH ΔH NNP cord-302530-pp6bl941 274 18 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 274 19 and and CC cord-302530-pp6bl941 274 20 ΔS ΔS NNP cord-302530-pp6bl941 274 21 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 274 22 respectively respectively RB cord-302530-pp6bl941 274 23 for for IN cord-302530-pp6bl941 274 24 the the DT cord-302530-pp6bl941 274 25 HIV HIV NNP cord-302530-pp6bl941 274 26 model model NN cord-302530-pp6bl941 274 27 in in IN cord-302530-pp6bl941 274 28 Fig Fig NNP cord-302530-pp6bl941 274 29 . . . cord-302530-pp6bl941 275 1 4c 4c NNP cord-302530-pp6bl941 275 2 and and CC cord-302530-pp6bl941 275 3 d d XX cord-302530-pp6bl941 275 4 with with IN cord-302530-pp6bl941 275 5 the the DT cord-302530-pp6bl941 275 6 reference reference NN cord-302530-pp6bl941 275 7 temperature temperature NN cord-302530-pp6bl941 275 8 , , , cord-302530-pp6bl941 275 9 T T NNP cord-302530-pp6bl941 275 10 0 0 CD cord-302530-pp6bl941 275 11 , , , cord-302530-pp6bl941 275 12 set set VBN cord-302530-pp6bl941 275 13 to to IN cord-302530-pp6bl941 275 14 4 4 CD cord-302530-pp6bl941 275 15 ° ° NN cord-302530-pp6bl941 275 16 C c NN cord-302530-pp6bl941 275 17 to to TO cord-302530-pp6bl941 275 18 assess assess VB cord-302530-pp6bl941 275 19 the the DT cord-302530-pp6bl941 275 20 effect effect NN cord-302530-pp6bl941 275 21 of of IN cord-302530-pp6bl941 275 22 varying vary VBG cord-302530-pp6bl941 275 23 ΔC ΔC NNP cord-302530-pp6bl941 275 24 p p NN cord-302530-pp6bl941 275 25 on on IN cord-302530-pp6bl941 275 26 the the DT cord-302530-pp6bl941 275 27 temperature temperature NN cord-302530-pp6bl941 275 28 sensitivity sensitivity NN cord-302530-pp6bl941 275 29 of of IN cord-302530-pp6bl941 275 30 K K NNP cord-302530-pp6bl941 275 31 a_virus_T a_virus_T NNP cord-302530-pp6bl941 275 32 and and CC cord-302530-pp6bl941 275 33 C.V C.V NNP cord-302530-pp6bl941 275 34 T T NNP cord-302530-pp6bl941 275 35 up up RP cord-302530-pp6bl941 275 36 to to IN cord-302530-pp6bl941 275 37 and and CC cord-302530-pp6bl941 275 38 above above IN cord-302530-pp6bl941 275 39 human human JJ cord-302530-pp6bl941 275 40 body body NN cord-302530-pp6bl941 275 41 temperature temperature NN cord-302530-pp6bl941 275 42 . . . cord-302530-pp6bl941 276 1 The the DT cord-302530-pp6bl941 276 2 2.5 2.5 CD cord-302530-pp6bl941 276 3 to to IN cord-302530-pp6bl941 276 4 97.5 97.5 CD cord-302530-pp6bl941 276 5 percentile percentile JJ cord-302530-pp6bl941 276 6 range range NN cord-302530-pp6bl941 276 7 for for IN cord-302530-pp6bl941 276 8 the the DT cord-302530-pp6bl941 276 9 number number NN cord-302530-pp6bl941 276 10 of of IN cord-302530-pp6bl941 276 11 CD4 CD4 NNP cord-302530-pp6bl941 276 12 + + CC cord-302530-pp6bl941 276 13 T T NNP cord-302530-pp6bl941 276 14 cells cell NNS cord-302530-pp6bl941 276 15 in in IN cord-302530-pp6bl941 276 16 humans human NNS cord-302530-pp6bl941 276 17 is be VBZ cord-302530-pp6bl941 276 18 448 448 CD cord-302530-pp6bl941 276 19 to to TO cord-302530-pp6bl941 276 20 1611 1611 CD cord-302530-pp6bl941 276 21 cells cell NNS cord-302530-pp6bl941 276 22 per per IN cord-302530-pp6bl941 276 23 mm mm NN cord-302530-pp6bl941 276 24 3 3 CD cord-302530-pp6bl941 276 25 ( ( -LRB- cord-302530-pp6bl941 276 26 10 10 CD cord-302530-pp6bl941 276 27 −6 −6 NN cord-302530-pp6bl941 276 28 dm dm NNP cord-302530-pp6bl941 276 29 3 3 CD cord-302530-pp6bl941 276 30 ) ) -RRB- cord-302530-pp6bl941 276 31 of of IN cord-302530-pp6bl941 276 32 blood blood NN cord-302530-pp6bl941 276 33 with with IN cord-302530-pp6bl941 276 34 a a DT cord-302530-pp6bl941 276 35 mean mean NN cord-302530-pp6bl941 276 36 of of IN cord-302530-pp6bl941 276 37 919 919 CD cord-302530-pp6bl941 276 38 cells cell NNS cord-302530-pp6bl941 276 39 per per IN cord-302530-pp6bl941 276 40 mm mm NN cord-302530-pp6bl941 276 41 3 3 CD cord-302530-pp6bl941 277 1 ( ( -LRB- cord-302530-pp6bl941 277 2 Thakar Thakar NNP cord-302530-pp6bl941 277 3 et et FW cord-302530-pp6bl941 277 4 al al NNP cord-302530-pp6bl941 277 5 . . NNP cord-302530-pp6bl941 277 6 , , , cord-302530-pp6bl941 277 7 2011 2011 CD cord-302530-pp6bl941 277 8 ) ) -RRB- cord-302530-pp6bl941 277 9 . . . cord-302530-pp6bl941 278 1 The the DT cord-302530-pp6bl941 278 2 model model NN cord-302530-pp6bl941 278 3 here here RB cord-302530-pp6bl941 278 4 takes take VBZ cord-302530-pp6bl941 278 5 1 1 CD cord-302530-pp6bl941 278 6 mm mm CD cord-302530-pp6bl941 278 7 3 3 CD cord-302530-pp6bl941 278 8 Myszka Myszka NNP cord-302530-pp6bl941 278 9 et et NNP cord-302530-pp6bl941 278 10 al al NNP cord-302530-pp6bl941 278 11 . . . cord-302530-pp6bl941 279 1 ( ( -LRB- cord-302530-pp6bl941 279 2 2000 2000 CD cord-302530-pp6bl941 279 3 ) ) -RRB- cord-302530-pp6bl941 279 4 ) ) -RRB- cord-302530-pp6bl941 280 1 at at IN cord-302530-pp6bl941 280 2 37 37 CD cord-302530-pp6bl941 280 3 ° ° NN cord-302530-pp6bl941 280 4 c c NN cord-302530-pp6bl941 280 5 Calculated calculate VBN cord-302530-pp6bl941 280 6 from from IN cord-302530-pp6bl941 280 7 Eq Eq NNP cord-302530-pp6bl941 280 8 . . . cord-302530-pp6bl941 281 1 ( ( -LRB- cord-302530-pp6bl941 281 2 4 4 LS cord-302530-pp6bl941 281 3 ) ) -RRB- cord-302530-pp6bl941 281 4 using use VBG cord-302530-pp6bl941 281 5 ΔC ΔC NNP cord-302530-pp6bl941 281 6 p p NN cord-302530-pp6bl941 281 7 = = NN cord-302530-pp6bl941 281 8 −5.02 −5.02 NNP cord-302530-pp6bl941 281 9 kJ kJ NNP cord-302530-pp6bl941 281 10 / / SYM cord-302530-pp6bl941 281 11 mol mol NNP cord-302530-pp6bl941 281 12 / / SYM cord-302530-pp6bl941 281 13 K K NNP cord-302530-pp6bl941 281 14 ( ( -LRB- cord-302530-pp6bl941 281 15 Table Table NNP cord-302530-pp6bl941 281 16 3 3 CD cord-302530-pp6bl941 281 17 ) ) -RRB- cord-302530-pp6bl941 281 18 with with IN cord-302530-pp6bl941 281 19 T t NN cord-302530-pp6bl941 281 20 0 0 CD cord-302530-pp6bl941 281 21 = = SYM cord-302530-pp6bl941 281 22 310 310 CD cord-302530-pp6bl941 281 23 K k NN cord-302530-pp6bl941 281 24 ( ( -LRB- cord-302530-pp6bl941 281 25 37 37 CD cord-302530-pp6bl941 281 26 ° ° NN cord-302530-pp6bl941 281 27 C C NNP cord-302530-pp6bl941 281 28 ) ) -RRB- cord-302530-pp6bl941 281 29 . . . cord-302530-pp6bl941 282 1 d d NNP cord-302530-pp6bl941 282 2 Calculated calculate VBN cord-302530-pp6bl941 282 3 from from IN cord-302530-pp6bl941 282 4 Eq Eq NNP cord-302530-pp6bl941 282 5 . . . cord-302530-pp6bl941 283 1 ( ( -LRB- cord-302530-pp6bl941 283 2 6 6 LS cord-302530-pp6bl941 283 3 ) ) -RRB- cord-302530-pp6bl941 283 4 using use VBG cord-302530-pp6bl941 283 5 ΔC ΔC NNP cord-302530-pp6bl941 283 6 p p NN cord-302530-pp6bl941 283 7 = = NN cord-302530-pp6bl941 283 8 −5.02 −5.02 NNP cord-302530-pp6bl941 283 9 kJ kJ NNP cord-302530-pp6bl941 283 10 / / SYM cord-302530-pp6bl941 283 11 mol mol NNP cord-302530-pp6bl941 283 12 / / SYM cord-302530-pp6bl941 283 13 K K NNP cord-302530-pp6bl941 283 14 ( ( -LRB- cord-302530-pp6bl941 283 15 Table Table NNP cord-302530-pp6bl941 283 16 3 3 CD cord-302530-pp6bl941 283 17 ) ) -RRB- cord-302530-pp6bl941 283 18 with with IN cord-302530-pp6bl941 283 19 T t NN cord-302530-pp6bl941 283 20 0 0 CD cord-302530-pp6bl941 283 21 = = SYM cord-302530-pp6bl941 283 22 310 310 CD cord-302530-pp6bl941 283 23 K k NN cord-302530-pp6bl941 283 24 ( ( -LRB- cord-302530-pp6bl941 283 25 37 37 CD cord-302530-pp6bl941 283 26 ° ° NN cord-302530-pp6bl941 283 27 C C NNP cord-302530-pp6bl941 283 28 ) ) -RRB- cord-302530-pp6bl941 283 29 . . . cord-302530-pp6bl941 284 1 e e LS cord-302530-pp6bl941 284 2 Estimated estimate VBN cord-302530-pp6bl941 284 3 from from IN cord-302530-pp6bl941 284 4 values value NNS cord-302530-pp6bl941 284 5 for for IN cord-302530-pp6bl941 284 6 ΔH ΔH NNP cord-302530-pp6bl941 284 7 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 285 1 and and CC cord-302530-pp6bl941 285 2 -TΔS -TΔS : cord-302530-pp6bl941 285 3 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 285 4 presented present VBN cord-302530-pp6bl941 285 5 in in IN cord-302530-pp6bl941 285 6 Fig Fig NNP cord-302530-pp6bl941 285 7 . . . cord-302530-pp6bl941 286 1 4 4 CD cord-302530-pp6bl941 286 2 of of IN cord-302530-pp6bl941 286 3 Myszka Myszka NNP cord-302530-pp6bl941 286 4 et et NNP cord-302530-pp6bl941 286 5 al al NNP cord-302530-pp6bl941 286 6 . . . cord-302530-pp6bl941 287 1 ( ( -LRB- cord-302530-pp6bl941 287 2 2000 2000 CD cord-302530-pp6bl941 287 3 ) ) -RRB- cord-302530-pp6bl941 287 4 for for IN cord-302530-pp6bl941 287 5 gp120 gp120 NNP cord-302530-pp6bl941 287 6 binding bind VBG cord-302530-pp6bl941 287 7 to to IN cord-302530-pp6bl941 287 8 CD4 CD4 NNP cord-302530-pp6bl941 287 9 at at IN cord-302530-pp6bl941 287 10 25 25 CD cord-302530-pp6bl941 287 11 ° ° NN cord-302530-pp6bl941 287 12 C c NN cord-302530-pp6bl941 287 13 . . . cord-302530-pp6bl941 288 1 f f NNP cord-302530-pp6bl941 288 2 In in IN cord-302530-pp6bl941 288 3 good good JJ cord-302530-pp6bl941 288 4 agreement agreement NN cord-302530-pp6bl941 288 5 with with IN cord-302530-pp6bl941 288 6 ΔS ΔS NNP cord-302530-pp6bl941 288 7 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 288 8 value value NN cord-302530-pp6bl941 288 9 at at IN cord-302530-pp6bl941 288 10 T T NNP cord-302530-pp6bl941 288 11 = = SYM cord-302530-pp6bl941 288 12 298 298 CD cord-302530-pp6bl941 288 13 K k NN cord-302530-pp6bl941 288 14 ( ( -LRB- cord-302530-pp6bl941 288 15 25 25 CD cord-302530-pp6bl941 288 16 ° ° NN cord-302530-pp6bl941 288 17 C C NNP cord-302530-pp6bl941 288 18 ) ) -RRB- cord-302530-pp6bl941 288 19 of of IN cord-302530-pp6bl941 288 20 −492.8 −492.8 NNP cord-302530-pp6bl941 288 21 J J NNP cord-302530-pp6bl941 288 22 / / SYM cord-302530-pp6bl941 288 23 mol mol NNP cord-302530-pp6bl941 288 24 / / SYM cord-302530-pp6bl941 288 25 K K NNP cord-302530-pp6bl941 288 26 as as IN cord-302530-pp6bl941 288 27 calculated calculate VBN cord-302530-pp6bl941 288 28 from from IN cord-302530-pp6bl941 288 29 Eq Eq NNP cord-302530-pp6bl941 288 30 . . . cord-302530-pp6bl941 289 1 ( ( -LRB- cord-302530-pp6bl941 289 2 6 6 LS cord-302530-pp6bl941 289 3 ) ) -RRB- cord-302530-pp6bl941 289 4 using use VBG cord-302530-pp6bl941 289 5 ΔC ΔC NNP cord-302530-pp6bl941 289 6 p p NN cord-302530-pp6bl941 289 7 = = NN cord-302530-pp6bl941 289 8 −5.02 −5.02 NNP cord-302530-pp6bl941 289 9 kJ kJ NNP cord-302530-pp6bl941 289 10 / / SYM cord-302530-pp6bl941 289 11 mol mol NNP cord-302530-pp6bl941 289 12 / / SYM cord-302530-pp6bl941 289 13 K K NNP cord-302530-pp6bl941 289 14 ( ( -LRB- cord-302530-pp6bl941 289 15 Table Table NNP cord-302530-pp6bl941 289 16 3 3 CD cord-302530-pp6bl941 289 17 ) ) -RRB- cord-302530-pp6bl941 289 18 with with IN cord-302530-pp6bl941 289 19 T t NN cord-302530-pp6bl941 289 20 0 0 CD cord-302530-pp6bl941 289 21 = = SYM cord-302530-pp6bl941 289 22 310 310 CD cord-302530-pp6bl941 289 23 K k NN cord-302530-pp6bl941 289 24 ( ( -LRB- cord-302530-pp6bl941 289 25 37 37 CD cord-302530-pp6bl941 289 26 ° ° NN cord-302530-pp6bl941 289 27 C C NNP cord-302530-pp6bl941 289 28 ) ) -RRB- cord-302530-pp6bl941 289 29 and and CC cord-302530-pp6bl941 289 30 ΔS ΔS NNP cord-302530-pp6bl941 289 31 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 289 32 = = SYM cord-302530-pp6bl941 289 33 −691.04 −691.04 NNP cord-302530-pp6bl941 289 34 J J NNP cord-302530-pp6bl941 289 35 / / SYM cord-302530-pp6bl941 289 36 mol mol NNP cord-302530-pp6bl941 289 37 / / SYM cord-302530-pp6bl941 289 38 K K NNP cord-302530-pp6bl941 289 39 ( ( -LRB- cord-302530-pp6bl941 289 40 see see VB cord-302530-pp6bl941 289 41 b b NNP cord-302530-pp6bl941 289 42 ) ) -RRB- cord-302530-pp6bl941 289 43 . . . cord-302530-pp6bl941 290 1 of of IN cord-302530-pp6bl941 290 2 blood blood NN cord-302530-pp6bl941 290 3 with with IN cord-302530-pp6bl941 290 4 C C NNP cord-302530-pp6bl941 290 5 total total NN cord-302530-pp6bl941 290 6 = = SYM cord-302530-pp6bl941 290 7 10 10 CD cord-302530-pp6bl941 290 8 3 3 CD cord-302530-pp6bl941 290 9 CD4 CD4 NNP cord-302530-pp6bl941 290 10 + + CC cord-302530-pp6bl941 290 11 T t NN cord-302530-pp6bl941 290 12 cells cell NNS cord-302530-pp6bl941 290 13 and and CC cord-302530-pp6bl941 290 14 introduces introduce VBZ cord-302530-pp6bl941 290 15 V V NNP cord-302530-pp6bl941 290 16 total total NN cord-302530-pp6bl941 290 17 = = SYM cord-302530-pp6bl941 290 18 10 10 CD cord-302530-pp6bl941 290 19 5 5 CD cord-302530-pp6bl941 290 20 HIV HIV NNP cord-302530-pp6bl941 290 21 virions virion NNS cord-302530-pp6bl941 290 22 . . . cord-302530-pp6bl941 291 1 Dividing divide VBG cord-302530-pp6bl941 291 2 10 10 CD cord-302530-pp6bl941 291 3 5 5 CD cord-302530-pp6bl941 291 4 HIV HIV NNP cord-302530-pp6bl941 291 5 virions virion NNS cord-302530-pp6bl941 291 6 in in IN cord-302530-pp6bl941 291 7 10 10 CD cord-302530-pp6bl941 291 8 −6 −6 NNS cord-302530-pp6bl941 291 9 dm dm NNP cord-302530-pp6bl941 291 10 3 3 CD cord-302530-pp6bl941 291 11 by by IN cord-302530-pp6bl941 291 12 the the DT cord-302530-pp6bl941 291 13 Avogadro Avogadro NNP cord-302530-pp6bl941 291 14 number number NN cord-302530-pp6bl941 291 15 gives give VBZ cord-302530-pp6bl941 291 16 [ [ -LRB- cord-302530-pp6bl941 291 17 V V NNP cord-302530-pp6bl941 291 18 total total NN cord-302530-pp6bl941 291 19 ] ] -RRB- cord-302530-pp6bl941 291 20 = = NFP cord-302530-pp6bl941 292 1 1.7 1.7 CD cord-302530-pp6bl941 292 2 × × CD cord-302530-pp6bl941 292 3 10 10 CD cord-302530-pp6bl941 292 4 −13 −13 NNP cord-302530-pp6bl941 292 5 M. M. NNP cord-302530-pp6bl941 293 1 The the DT cord-302530-pp6bl941 293 2 advantage advantage NN cord-302530-pp6bl941 293 3 of of IN cord-302530-pp6bl941 293 4 using use VBG cord-302530-pp6bl941 293 5 a a DT cord-302530-pp6bl941 293 6 high high JJ cord-302530-pp6bl941 293 7 V v NN cord-302530-pp6bl941 293 8 total total NN cord-302530-pp6bl941 293 9 that that WDT cord-302530-pp6bl941 293 10 greatly greatly RB cord-302530-pp6bl941 293 11 exceeds exceed VBZ cord-302530-pp6bl941 293 12 C C NNP cord-302530-pp6bl941 293 13 total total NN cord-302530-pp6bl941 293 14 is be VBZ cord-302530-pp6bl941 293 15 that that IN cord-302530-pp6bl941 293 16 as as RB cord-302530-pp6bl941 293 17 previously previously RB cord-302530-pp6bl941 293 18 demonstrated demonstrate VBN cord-302530-pp6bl941 293 19 by by IN cord-302530-pp6bl941 293 20 Gale Gale NNP cord-302530-pp6bl941 293 21 ( ( -LRB- cord-302530-pp6bl941 293 22 2018 2018 CD cord-302530-pp6bl941 293 23 ) ) -RRB- cord-302530-pp6bl941 294 1 not not RB cord-302530-pp6bl941 294 2 only only RB cord-302530-pp6bl941 294 3 may may MD cord-302530-pp6bl941 294 4 the the DT cord-302530-pp6bl941 294 5 fraction fraction NN cord-302530-pp6bl941 294 6 , , , cord-302530-pp6bl941 294 7 F F NNP cord-302530-pp6bl941 294 8 cT cT NNP cord-302530-pp6bl941 294 9 , , , cord-302530-pp6bl941 294 10 of of IN cord-302530-pp6bl941 294 11 CD4 CD4 NNP cord-302530-pp6bl941 294 12 + + CC cord-302530-pp6bl941 294 13 T t NN cord-302530-pp6bl941 294 14 cells cell NNS cord-302530-pp6bl941 294 15 with with IN cord-302530-pp6bl941 294 16 bound bind VBN cord-302530-pp6bl941 294 17 HIV HIV NNP cord-302530-pp6bl941 294 18 be be VB cord-302530-pp6bl941 294 19 calculated calculate VBN cord-302530-pp6bl941 294 20 from from IN cord-302530-pp6bl941 294 21 Eq Eq NNP cord-302530-pp6bl941 294 22 . . . cord-302530-pp6bl941 295 1 ( ( -LRB- cord-302530-pp6bl941 295 2 13 13 CD cord-302530-pp6bl941 295 3 ) ) -RRB- cord-302530-pp6bl941 295 4 with with IN cord-302530-pp6bl941 295 5 [ [ -LRB- cord-302530-pp6bl941 295 6 V v NN cord-302530-pp6bl941 295 7 free free JJ cord-302530-pp6bl941 295 8 ] ] -RRB- cord-302530-pp6bl941 296 1 ~[V ~[V NFP cord-302530-pp6bl941 296 2 total total NN cord-302530-pp6bl941 296 3 ] ] -RRB- cord-302530-pp6bl941 296 4 but but CC cord-302530-pp6bl941 296 5 also also RB cord-302530-pp6bl941 296 6 any any DT cord-302530-pp6bl941 296 7 complications complication NNS cord-302530-pp6bl941 296 8 of of IN cord-302530-pp6bl941 296 9 handling handle VBG cord-302530-pp6bl941 296 10 stochastic stochastic JJ cord-302530-pp6bl941 296 11 effects effect NNS cord-302530-pp6bl941 296 12 at at IN cord-302530-pp6bl941 296 13 low low JJ cord-302530-pp6bl941 296 14 virus virus NN cord-302530-pp6bl941 296 15 doses dose NNS cord-302530-pp6bl941 296 16 are be VBP cord-302530-pp6bl941 296 17 avoided avoid VBN cord-302530-pp6bl941 296 18 . . . cord-302530-pp6bl941 297 1 It -PRON- PRP cord-302530-pp6bl941 297 2 is be VBZ cord-302530-pp6bl941 297 3 recognised recognise VBN cord-302530-pp6bl941 297 4 that that IN cord-302530-pp6bl941 297 5 the the DT cord-302530-pp6bl941 297 6 HIV HIV NNP cord-302530-pp6bl941 297 7 concentration concentration NN cord-302530-pp6bl941 297 8 at at IN cord-302530-pp6bl941 297 9 10 10 CD cord-302530-pp6bl941 297 10 5 5 CD cord-302530-pp6bl941 297 11 HIV HIV NNP cord-302530-pp6bl941 297 12 virions virion NNS cord-302530-pp6bl941 297 13 per per IN cord-302530-pp6bl941 297 14 mm mm NN cord-302530-pp6bl941 297 15 3 3 CD cord-302530-pp6bl941 297 16 used use VBN cord-302530-pp6bl941 297 17 in in IN cord-302530-pp6bl941 297 18 this this DT cord-302530-pp6bl941 297 19 model model NN cord-302530-pp6bl941 297 20 is be VBZ cord-302530-pp6bl941 297 21 10-fold 10-fold JJ cord-302530-pp6bl941 297 22 to to IN cord-302530-pp6bl941 297 23 100-fold 100-fold CD cord-302530-pp6bl941 297 24 higher high JJR cord-302530-pp6bl941 297 25 than than IN cord-302530-pp6bl941 297 26 that that DT cord-302530-pp6bl941 297 27 expected expect VBN cord-302530-pp6bl941 297 28 in in IN cord-302530-pp6bl941 297 29 a a DT cord-302530-pp6bl941 297 30 recipient recipient NN cord-302530-pp6bl941 297 31 person person NN cord-302530-pp6bl941 297 32 's 's POS cord-302530-pp6bl941 297 33 blood blood NN cord-302530-pp6bl941 297 34 present present JJ cord-302530-pp6bl941 297 35 in in IN cord-302530-pp6bl941 297 36 the the DT cord-302530-pp6bl941 297 37 capillaries capillary NNS cord-302530-pp6bl941 297 38 lining line VBG cord-302530-pp6bl941 297 39 the the DT cord-302530-pp6bl941 297 40 skin skin NN cord-302530-pp6bl941 297 41 at at IN cord-302530-pp6bl941 297 42 the the DT cord-302530-pp6bl941 297 43 wound wound NN cord-302530-pp6bl941 297 44 site site NN cord-302530-pp6bl941 297 45 where where WRB cord-302530-pp6bl941 297 46 semen semen NN cord-302530-pp6bl941 297 47 or or CC cord-302530-pp6bl941 297 48 blood blood NN cord-302530-pp6bl941 297 49 from from IN cord-302530-pp6bl941 297 50 an an DT cord-302530-pp6bl941 297 51 infected infected JJ cord-302530-pp6bl941 297 52 source source NN cord-302530-pp6bl941 297 53 were be VBD cord-302530-pp6bl941 297 54 introduced introduce VBN cord-302530-pp6bl941 297 55 since since IN cord-302530-pp6bl941 297 56 maximum maximum JJ cord-302530-pp6bl941 297 57 human human JJ cord-302530-pp6bl941 297 58 plasma plasma NN cord-302530-pp6bl941 297 59 and and CC cord-302530-pp6bl941 297 60 human human JJ cord-302530-pp6bl941 297 61 semen semen NN cord-302530-pp6bl941 297 62 HIV HIV NNP cord-302530-pp6bl941 297 63 loadings loading NNS cord-302530-pp6bl941 297 64 are be VBP cord-302530-pp6bl941 297 65 in in IN cord-302530-pp6bl941 297 66 the the DT cord-302530-pp6bl941 297 67 region region NN cord-302530-pp6bl941 297 68 of of IN cord-302530-pp6bl941 297 69 13,000 13,000 CD cord-302530-pp6bl941 297 70 copies copy NNS cord-302530-pp6bl941 297 71 per per IN cord-302530-pp6bl941 297 72 mm mm NNP cord-302530-pp6bl941 297 73 3 3 CD cord-302530-pp6bl941 297 74 and and CC cord-302530-pp6bl941 297 75 1800 1800 CD cord-302530-pp6bl941 297 76 copies copy NNS cord-302530-pp6bl941 297 77 per per IN cord-302530-pp6bl941 297 78 mm mm NN cord-302530-pp6bl941 297 79 3 3 CD cord-302530-pp6bl941 297 80 respectively respectively RB cord-302530-pp6bl941 297 81 ( ( -LRB- cord-302530-pp6bl941 297 82 Gupta Gupta NNP cord-302530-pp6bl941 297 83 et et NNP cord-302530-pp6bl941 297 84 al al NNP cord-302530-pp6bl941 297 85 . . NNP cord-302530-pp6bl941 297 86 , , , cord-302530-pp6bl941 297 87 1997 1997 CD cord-302530-pp6bl941 297 88 ) ) -RRB- cord-302530-pp6bl941 297 89 . . . cord-302530-pp6bl941 298 1 This this DT cord-302530-pp6bl941 298 2 is be VBZ cord-302530-pp6bl941 298 3 not not RB cord-302530-pp6bl941 298 4 important important JJ cord-302530-pp6bl941 298 5 , , , cord-302530-pp6bl941 298 6 however however RB cord-302530-pp6bl941 298 7 , , , cord-302530-pp6bl941 298 8 because because IN cord-302530-pp6bl941 298 9 the the DT cord-302530-pp6bl941 298 10 purpose purpose NN cord-302530-pp6bl941 298 11 of of IN cord-302530-pp6bl941 298 12 the the DT cord-302530-pp6bl941 298 13 models model NNS cord-302530-pp6bl941 298 14 here here RB cord-302530-pp6bl941 298 15 in in IN cord-302530-pp6bl941 298 16 Figs fig NNS cord-302530-pp6bl941 298 17 . . . cord-302530-pp6bl941 299 1 4 4 LS cord-302530-pp6bl941 299 2 - - SYM cord-302530-pp6bl941 299 3 6 6 CD cord-302530-pp6bl941 299 4 is be VBZ cord-302530-pp6bl941 299 5 not not RB cord-302530-pp6bl941 299 6 to to TO cord-302530-pp6bl941 299 7 produce produce VB cord-302530-pp6bl941 299 8 a a DT cord-302530-pp6bl941 299 9 realistic realistic JJ cord-302530-pp6bl941 299 10 dose dose NN cord-302530-pp6bl941 299 11 - - HYPH cord-302530-pp6bl941 299 12 response response NN cord-302530-pp6bl941 299 13 but but CC cord-302530-pp6bl941 299 14 to to TO cord-302530-pp6bl941 299 15 explore explore VB cord-302530-pp6bl941 299 16 the the DT cord-302530-pp6bl941 299 17 effect effect NN cord-302530-pp6bl941 299 18 of of IN cord-302530-pp6bl941 299 19 changing change VBG cord-302530-pp6bl941 299 20 ΔC ΔC NNP cord-302530-pp6bl941 299 21 p p NN cord-302530-pp6bl941 299 22 , , , cord-302530-pp6bl941 299 23 ΔS ΔS NNP cord-302530-pp6bl941 299 24 a_immob a_immob NNP cord-302530-pp6bl941 299 25 , , , cord-302530-pp6bl941 299 26 n n NN cord-302530-pp6bl941 299 27 and and CC cord-302530-pp6bl941 299 28 temperature temperature NN cord-302530-pp6bl941 299 29 on on IN cord-302530-pp6bl941 299 30 the the DT cord-302530-pp6bl941 299 31 trend trend NN cord-302530-pp6bl941 299 32 in in IN cord-302530-pp6bl941 299 33 the the DT cord-302530-pp6bl941 299 34 predicted predict VBN cord-302530-pp6bl941 299 35 number number NN cord-302530-pp6bl941 299 36 , , , cord-302530-pp6bl941 299 37 C.V C.V NNP cord-302530-pp6bl941 299 38 T T NNP cord-302530-pp6bl941 299 39 , , , cord-302530-pp6bl941 299 40 of of IN cord-302530-pp6bl941 299 41 host host NN cord-302530-pp6bl941 299 42 CD4 CD4 NNP cord-302530-pp6bl941 299 43 + + CC cord-302530-pp6bl941 299 44 T t NN cord-302530-pp6bl941 299 45 cells cell NNS cord-302530-pp6bl941 299 46 with with IN cord-302530-pp6bl941 299 47 bound bind VBN cord-302530-pp6bl941 299 48 virus virus NN cord-302530-pp6bl941 299 49 . . . cord-302530-pp6bl941 300 1 Indeed indeed RB cord-302530-pp6bl941 300 2 , , , cord-302530-pp6bl941 300 3 the the DT cord-302530-pp6bl941 300 4 overall overall JJ cord-302530-pp6bl941 300 5 conclusions conclusion NNS cord-302530-pp6bl941 300 6 of of IN cord-302530-pp6bl941 300 7 the the DT cord-302530-pp6bl941 300 8 model model NN cord-302530-pp6bl941 300 9 in in IN cord-302530-pp6bl941 300 10 terms term NNS cord-302530-pp6bl941 300 11 of of IN cord-302530-pp6bl941 300 12 the the DT cord-302530-pp6bl941 300 13 effect effect NN cord-302530-pp6bl941 300 14 of of IN cord-302530-pp6bl941 300 15 temperature temperature NN cord-302530-pp6bl941 300 16 on on IN cord-302530-pp6bl941 300 17 the the DT cord-302530-pp6bl941 300 18 number number NN cord-302530-pp6bl941 300 19 of of IN cord-302530-pp6bl941 300 20 CD4 CD4 NNP cord-302530-pp6bl941 300 21 + + CC cord-302530-pp6bl941 300 22 T t NN cord-302530-pp6bl941 300 23 cells cell NNS cord-302530-pp6bl941 300 24 with with IN cord-302530-pp6bl941 300 25 bound bind VBN cord-302530-pp6bl941 300 26 virus virus NN cord-302530-pp6bl941 300 27 will will MD cord-302530-pp6bl941 300 28 still still RB cord-302530-pp6bl941 300 29 be be VB cord-302530-pp6bl941 300 30 representative representative JJ cord-302530-pp6bl941 300 31 and and CC cord-302530-pp6bl941 300 32 the the DT cord-302530-pp6bl941 300 33 interpretation interpretation NN cord-302530-pp6bl941 300 34 applicable applicable JJ cord-302530-pp6bl941 300 35 to to IN cord-302530-pp6bl941 300 36 all all DT cord-302530-pp6bl941 300 37 doses dose NNS cord-302530-pp6bl941 300 38 of of IN cord-302530-pp6bl941 300 39 viruses virus NNS cord-302530-pp6bl941 300 40 as as IN cord-302530-pp6bl941 300 41 there there EX cord-302530-pp6bl941 300 42 is be VBZ cord-302530-pp6bl941 300 43 no no DT cord-302530-pp6bl941 300 44 cooperation cooperation NN cord-302530-pp6bl941 300 45 between between IN cord-302530-pp6bl941 300 46 viruses virus NNS cord-302530-pp6bl941 300 47 in in IN cord-302530-pp6bl941 300 48 this this DT cord-302530-pp6bl941 300 49 model model NN cord-302530-pp6bl941 300 50 ( ( -LRB- cord-302530-pp6bl941 300 51 Gale Gale NNP cord-302530-pp6bl941 300 52 2018 2018 CD cord-302530-pp6bl941 300 53 ) ) -RRB- cord-302530-pp6bl941 300 54 . . . cord-302530-pp6bl941 301 1 Furthermore furthermore RB cord-302530-pp6bl941 301 2 , , , cord-302530-pp6bl941 301 3 the the DT cord-302530-pp6bl941 301 4 levels level NNS cord-302530-pp6bl941 301 5 of of IN cord-302530-pp6bl941 301 6 SIV SIV NNP cord-302530-pp6bl941 301 7 in in IN cord-302530-pp6bl941 301 8 Rhesus Rhesus NNP cord-302530-pp6bl941 301 9 monkey monkey NN cord-302530-pp6bl941 301 10 blood blood NN cord-302530-pp6bl941 301 11 plasma plasma NN cord-302530-pp6bl941 301 12 were be VBD cord-302530-pp6bl941 301 13 in in IN cord-302530-pp6bl941 301 14 the the DT cord-302530-pp6bl941 301 15 region region NN cord-302530-pp6bl941 301 16 of of IN cord-302530-pp6bl941 301 17 2.1 2.1 CD cord-302530-pp6bl941 301 18 × × CD cord-302530-pp6bl941 301 19 10 10 CD cord-302530-pp6bl941 301 20 8 8 CD cord-302530-pp6bl941 301 21 virions virion NNS cord-302530-pp6bl941 301 22 per per IN cord-302530-pp6bl941 301 23 ml ml NN cord-302530-pp6bl941 301 24 ( ( -LRB- cord-302530-pp6bl941 301 25 Huitron Huitron NNP cord-302530-pp6bl941 301 26 - - HYPH cord-302530-pp6bl941 301 27 Resendiz Resendiz NNP cord-302530-pp6bl941 301 28 et et NNP cord-302530-pp6bl941 301 29 al al NNP cord-302530-pp6bl941 301 30 . . NNP cord-302530-pp6bl941 301 31 , , , cord-302530-pp6bl941 301 32 2007 2007 CD cord-302530-pp6bl941 301 33 ) ) -RRB- cord-302530-pp6bl941 301 34 which which WDT cord-302530-pp6bl941 301 35 is be VBZ cord-302530-pp6bl941 301 36 2.1 2.1 CD cord-302530-pp6bl941 301 37 × × CD cord-302530-pp6bl941 301 38 10 10 CD cord-302530-pp6bl941 301 39 5 5 CD cord-302530-pp6bl941 301 40 virions virion NNS cord-302530-pp6bl941 301 41 per per IN cord-302530-pp6bl941 301 42 mm mm NNP cord-302530-pp6bl941 301 43 3 3 CD cord-302530-pp6bl941 301 44 and and CC cord-302530-pp6bl941 301 45 representative representative NN cord-302530-pp6bl941 301 46 of of IN cord-302530-pp6bl941 301 47 the the DT cord-302530-pp6bl941 301 48 10 10 CD cord-302530-pp6bl941 301 49 5 5 CD cord-302530-pp6bl941 301 50 used use VBN cord-302530-pp6bl941 301 51 for for IN cord-302530-pp6bl941 301 52 [ [ -LRB- cord-302530-pp6bl941 301 53 V V NNP cord-302530-pp6bl941 301 54 total total NN cord-302530-pp6bl941 301 55 ] ] -RRB- cord-302530-pp6bl941 301 56 in in IN cord-302530-pp6bl941 301 57 the the DT cord-302530-pp6bl941 301 58 model model NN cord-302530-pp6bl941 301 59 here here RB cord-302530-pp6bl941 301 60 . . . cord-302530-pp6bl941 302 1 C.V C.V NNP cord-302530-pp6bl941 302 2 T T NNP cord-302530-pp6bl941 302 3 is be VBZ cord-302530-pp6bl941 302 4 calculated calculate VBN cord-302530-pp6bl941 302 5 by by IN cord-302530-pp6bl941 302 6 multiplying multiply VBG cord-302530-pp6bl941 302 7 F F NNP cord-302530-pp6bl941 302 8 cT cT NNP cord-302530-pp6bl941 302 9 by by IN cord-302530-pp6bl941 302 10 C C NNP cord-302530-pp6bl941 302 11 total total NN cord-302530-pp6bl941 302 12 ( ( -LRB- cord-302530-pp6bl941 302 13 Eq Eq NNP cord-302530-pp6bl941 302 14 . . . cord-302530-pp6bl941 303 1 ( ( -LRB- cord-302530-pp6bl941 303 2 14 14 CD cord-302530-pp6bl941 303 3 ) ) -RRB- cord-302530-pp6bl941 303 4 ) ) -RRB- cord-302530-pp6bl941 303 5 . . . cord-302530-pp6bl941 304 1 2.6 2.6 CD cord-302530-pp6bl941 304 2 . . . cord-302530-pp6bl941 305 1 Case case NN cord-302530-pp6bl941 305 2 study study NN cord-302530-pp6bl941 305 3 4 4 CD cord-302530-pp6bl941 305 4 : : : cord-302530-pp6bl941 306 1 A a DT cord-302530-pp6bl941 306 2 large large JJ cord-302530-pp6bl941 306 3 virus virus NN cord-302530-pp6bl941 306 4 diameter diameter NN cord-302530-pp6bl941 306 5 such such JJ cord-302530-pp6bl941 306 6 as as IN cord-302530-pp6bl941 306 7 for for IN cord-302530-pp6bl941 306 8 the the DT cord-302530-pp6bl941 306 9 HIV HIV NNP cord-302530-pp6bl941 306 10 virion virion NN cord-302530-pp6bl941 306 11 diminishes diminish VBZ cord-302530-pp6bl941 306 12 host host NN cord-302530-pp6bl941 306 13 cell cell NN cord-302530-pp6bl941 306 14 binding bind VBG cord-302530-pp6bl941 306 15 at at IN cord-302530-pp6bl941 306 16 the the DT cord-302530-pp6bl941 306 17 higher high JJR cord-302530-pp6bl941 306 18 temperatures temperature NNS cord-302530-pp6bl941 306 19 of of IN cord-302530-pp6bl941 306 20 the the DT cord-302530-pp6bl941 306 21 human human JJ cord-302530-pp6bl941 306 22 body body NN cord-302530-pp6bl941 306 23 through through IN cord-302530-pp6bl941 306 24 the the DT cord-302530-pp6bl941 306 25 large large JJ cord-302530-pp6bl941 306 26 negative negative JJ cord-302530-pp6bl941 306 27 ΔS ΔS NNP cord-302530-pp6bl941 306 28 a_immob a_immob NN cord-302530-pp6bl941 307 1 2.6.1 2.6.1 UH cord-302530-pp6bl941 307 2 . . . cord-302530-pp6bl941 308 1 Estimation estimation NN cord-302530-pp6bl941 308 2 of of IN cord-302530-pp6bl941 308 3 ΔS ΔS NNP cord-302530-pp6bl941 308 4 a_immob a_immob NNP cord-302530-pp6bl941 308 5 for for IN cord-302530-pp6bl941 308 6 a a DT cord-302530-pp6bl941 308 7 virus virus NN cord-302530-pp6bl941 309 1 There there EX cord-302530-pp6bl941 309 2 are be VBP cord-302530-pp6bl941 309 3 currently currently RB cord-302530-pp6bl941 309 4 no no DT cord-302530-pp6bl941 309 5 data datum NNS cord-302530-pp6bl941 309 6 available available JJ cord-302530-pp6bl941 309 7 on on IN cord-302530-pp6bl941 309 8 the the DT cord-302530-pp6bl941 309 9 magnitude magnitude NN cord-302530-pp6bl941 309 10 of of IN cord-302530-pp6bl941 309 11 ΔS ΔS NNP cord-302530-pp6bl941 309 12 a_immob a_immob NNP cord-302530-pp6bl941 309 13 which which WDT cord-302530-pp6bl941 309 14 was be VBD cord-302530-pp6bl941 309 15 first first RB cord-302530-pp6bl941 309 16 defined define VBN cord-302530-pp6bl941 309 17 through through IN cord-302530-pp6bl941 309 18 development development NN cord-302530-pp6bl941 309 19 of of IN cord-302530-pp6bl941 309 20 a a DT cord-302530-pp6bl941 309 21 thermodynamic thermodynamic JJ cord-302530-pp6bl941 309 22 model model NN cord-302530-pp6bl941 309 23 ( ( -LRB- cord-302530-pp6bl941 309 24 Gale Gale NNP cord-302530-pp6bl941 309 25 2019 2019 CD cord-302530-pp6bl941 309 26 ) ) -RRB- cord-302530-pp6bl941 309 27 . . . cord-302530-pp6bl941 310 1 Xiong Xiong NNP cord-302530-pp6bl941 310 2 et et NNP cord-302530-pp6bl941 310 3 al al NNP cord-302530-pp6bl941 310 4 . . . cord-302530-pp6bl941 311 1 ( ( -LRB- cord-302530-pp6bl941 311 2 2013 2013 CD cord-302530-pp6bl941 311 3 ) ) -RRB- cord-302530-pp6bl941 311 4 reported report VBD cord-302530-pp6bl941 311 5 a a DT cord-302530-pp6bl941 311 6 K K NNP cord-302530-pp6bl941 311 7 d_virus d_virus NN cord-302530-pp6bl941 311 8 of of IN cord-302530-pp6bl941 311 9 10 10 CD cord-302530-pp6bl941 311 10 −15 −15 NNP cord-302530-pp6bl941 311 11 M M NNP cord-302530-pp6bl941 311 12 for for IN cord-302530-pp6bl941 311 13 AIV AIV NNP cord-302530-pp6bl941 311 14 where where WRB cord-302530-pp6bl941 311 15 K K NNP cord-302530-pp6bl941 311 16 d_virus d_virus NNP cord-302530-pp6bl941 311 17 is be VBZ cord-302530-pp6bl941 311 18 the the DT cord-302530-pp6bl941 311 19 dissociation dissociation NN cord-302530-pp6bl941 311 20 constant constant JJ cord-302530-pp6bl941 311 21 for for IN cord-302530-pp6bl941 311 22 virus virus NN cord-302530-pp6bl941 311 23 from from IN cord-302530-pp6bl941 311 24 the the DT cord-302530-pp6bl941 311 25 host host NN cord-302530-pp6bl941 311 26 cell cell NN cord-302530-pp6bl941 311 27 and and CC cord-302530-pp6bl941 311 28 is be VBZ cord-302530-pp6bl941 311 29 the the DT cord-302530-pp6bl941 311 30 inverse inverse NN cord-302530-pp6bl941 311 31 of of IN cord-302530-pp6bl941 311 32 K K NNP cord-302530-pp6bl941 311 33 a_virus_T a_virus_T NNP cord-302530-pp6bl941 311 34 . . . cord-302530-pp6bl941 312 1 According accord VBG cord-302530-pp6bl941 312 2 to to IN cord-302530-pp6bl941 312 3 Yang Yang NNP cord-302530-pp6bl941 312 4 et et NNP cord-302530-pp6bl941 312 5 al al NNP cord-302530-pp6bl941 312 6 . . . cord-302530-pp6bl941 313 1 ( ( -LRB- cord-302530-pp6bl941 313 2 2005 2005 CD cord-302530-pp6bl941 313 3 ) ) -RRB- cord-302530-pp6bl941 314 1 HIV HIV NNP cord-302530-pp6bl941 314 2 virions virion NNS cord-302530-pp6bl941 314 3 bearing bear VBG cord-302530-pp6bl941 314 4 influenza influenza NN cord-302530-pp6bl941 314 5 A a DT cord-302530-pp6bl941 314 6 virus virus NN cord-302530-pp6bl941 314 7 HA HA NNP cord-302530-pp6bl941 314 8 required require VBD cord-302530-pp6bl941 314 9 8 8 CD cord-302530-pp6bl941 314 10 or or CC cord-302530-pp6bl941 314 11 9 9 CD cord-302530-pp6bl941 314 12 HA HA NNP cord-302530-pp6bl941 314 13 trimers trimer NNS cord-302530-pp6bl941 314 14 for for IN cord-302530-pp6bl941 314 15 virus virus NN cord-302530-pp6bl941 314 16 entry entry NN cord-302530-pp6bl941 314 17 . . . cord-302530-pp6bl941 315 1 This this DT cord-302530-pp6bl941 315 2 is be VBZ cord-302530-pp6bl941 315 3 equivalent equivalent JJ cord-302530-pp6bl941 315 4 to to IN cord-302530-pp6bl941 315 5 n n NN cord-302530-pp6bl941 315 6 = = SYM cord-302530-pp6bl941 315 7 24 24 CD cord-302530-pp6bl941 315 8 to to IN cord-302530-pp6bl941 315 9 27 27 CD cord-302530-pp6bl941 315 10 HA HA NNP cord-302530-pp6bl941 315 11 monomers monomer NNS cord-302530-pp6bl941 315 12 each each DT cord-302530-pp6bl941 315 13 of of IN cord-302530-pp6bl941 315 14 K K NNP cord-302530-pp6bl941 315 15 d_receptor d_receptor NNP cord-302530-pp6bl941 316 1 = = NFP cord-302530-pp6bl941 317 1 10 10 CD cord-302530-pp6bl941 318 1 −3 −3 NNP cord-302530-pp6bl941 318 2 M M NNP cord-302530-pp6bl941 318 3 ( ( -LRB- cord-302530-pp6bl941 318 4 Xiong Xiong NNP cord-302530-pp6bl941 318 5 et et NNP cord-302530-pp6bl941 318 6 al al NNP cord-302530-pp6bl941 318 7 . . NNP cord-302530-pp6bl941 318 8 , , , cord-302530-pp6bl941 318 9 2013 2013 CD cord-302530-pp6bl941 318 10 ) ) -RRB- cord-302530-pp6bl941 318 11 . . . cord-302530-pp6bl941 319 1 It -PRON- PRP cord-302530-pp6bl941 319 2 is be VBZ cord-302530-pp6bl941 319 3 not not RB cord-302530-pp6bl941 319 4 clear clear JJ cord-302530-pp6bl941 319 5 whether whether IN cord-302530-pp6bl941 319 6 the the DT cord-302530-pp6bl941 319 7 8 8 CD cord-302530-pp6bl941 319 8 or or CC cord-302530-pp6bl941 319 9 9 9 CD cord-302530-pp6bl941 319 10 AIV AIV NNP cord-302530-pp6bl941 319 11 HA HA NNP cord-302530-pp6bl941 319 12 trimers trimer NNS cord-302530-pp6bl941 319 13 are be VBP cord-302530-pp6bl941 319 14 required require VBN cord-302530-pp6bl941 319 15 for for IN cord-302530-pp6bl941 319 16 cell cell NN cord-302530-pp6bl941 319 17 binding binding NN cord-302530-pp6bl941 319 18 or or CC cord-302530-pp6bl941 319 19 membrane membrane NN cord-302530-pp6bl941 319 20 fusion fusion NN cord-302530-pp6bl941 319 21 in in IN cord-302530-pp6bl941 319 22 Yang Yang NNP cord-302530-pp6bl941 319 23 et et NNP cord-302530-pp6bl941 319 24 al al NNP cord-302530-pp6bl941 319 25 . . . cord-302530-pp6bl941 320 1 ( ( -LRB- cord-302530-pp6bl941 320 2 2005 2005 CD cord-302530-pp6bl941 320 3 ) ) -RRB- cord-302530-pp6bl941 320 4 . . . cord-302530-pp6bl941 321 1 However however RB cord-302530-pp6bl941 321 2 , , , cord-302530-pp6bl941 321 3 if if IN cord-302530-pp6bl941 321 4 n n NN cord-302530-pp6bl941 321 5 = = SYM cord-302530-pp6bl941 321 6 24 24 CD cord-302530-pp6bl941 321 7 HA HA NNP cord-302530-pp6bl941 321 8 monomers monomer NNS cord-302530-pp6bl941 321 9 are be VBP cord-302530-pp6bl941 321 10 required require VBN cord-302530-pp6bl941 321 11 for for IN cord-302530-pp6bl941 321 12 AIV AIV NNP cord-302530-pp6bl941 321 13 binding bind VBG cord-302530-pp6bl941 321 14 to to IN cord-302530-pp6bl941 321 15 the the DT cord-302530-pp6bl941 321 16 host host NN cord-302530-pp6bl941 321 17 cell cell NN cord-302530-pp6bl941 321 18 to to TO cord-302530-pp6bl941 321 19 give give VB cord-302530-pp6bl941 321 20 a a DT cord-302530-pp6bl941 321 21 K K NNP cord-302530-pp6bl941 321 22 a_virus_T a_virus_T NNP cord-302530-pp6bl941 321 23 of of IN cord-302530-pp6bl941 321 24 10 10 CD cord-302530-pp6bl941 321 25 15 15 CD cord-302530-pp6bl941 321 26 M M NNP cord-302530-pp6bl941 321 27 −1 −1 NNP cord-302530-pp6bl941 321 28 then then RB cord-302530-pp6bl941 321 29 ΔS ΔS NNP cord-302530-pp6bl941 321 30 a_immob a_immob NNP cord-302530-pp6bl941 321 31 equals equal VBZ cord-302530-pp6bl941 321 32 −1091 −1091 NNP cord-302530-pp6bl941 321 33 J J NNP cord-302530-pp6bl941 321 34 / / SYM cord-302530-pp6bl941 321 35 mol mol NNP cord-302530-pp6bl941 321 36 / / SYM cord-302530-pp6bl941 321 37 K K NNP cord-302530-pp6bl941 321 38 from from IN cord-302530-pp6bl941 321 39 Eq Eq NNP cord-302530-pp6bl941 321 40 . . . cord-302530-pp6bl941 322 1 ( ( -LRB- cord-302530-pp6bl941 322 2 17 17 CD cord-302530-pp6bl941 322 3 ) ) -RRB- cord-302530-pp6bl941 323 1 ( ( -LRB- cord-302530-pp6bl941 323 2 derived derive VBN cord-302530-pp6bl941 323 3 in in IN cord-302530-pp6bl941 323 4 Gale Gale NNP cord-302530-pp6bl941 323 5 2019 2019 CD cord-302530-pp6bl941 323 6 ) ) -RRB- cord-302530-pp6bl941 323 7 . . . cord-302530-pp6bl941 324 1 This this DT cord-302530-pp6bl941 324 2 is be VBZ cord-302530-pp6bl941 324 3 in in IN cord-302530-pp6bl941 324 4 the the DT cord-302530-pp6bl941 324 5 same same JJ cord-302530-pp6bl941 324 6 order order NN cord-302530-pp6bl941 324 7 of of IN cord-302530-pp6bl941 324 8 magnitude magnitude NN cord-302530-pp6bl941 324 9 as as IN cord-302530-pp6bl941 324 10 assumed assume VBN cord-302530-pp6bl941 324 11 for for IN cord-302530-pp6bl941 324 12 ΔS ΔS NNP cord-302530-pp6bl941 324 13 a_immob a_immob NNP cord-302530-pp6bl941 324 14 on on IN cord-302530-pp6bl941 324 15 the the DT cord-302530-pp6bl941 324 16 basis basis NN cord-302530-pp6bl941 324 17 of of IN cord-302530-pp6bl941 324 18 virus virus NN cord-302530-pp6bl941 324 19 molecular molecular JJ cord-302530-pp6bl941 324 20 weight weight NN cord-302530-pp6bl941 324 21 ( ( -LRB- cord-302530-pp6bl941 324 22 Gale Gale NNP cord-302530-pp6bl941 324 23 2019 2019 CD cord-302530-pp6bl941 324 24 ) ) -RRB- cord-302530-pp6bl941 324 25 . . . cord-302530-pp6bl941 325 1 It -PRON- PRP cord-302530-pp6bl941 325 2 must must MD cord-302530-pp6bl941 325 3 be be VB cord-302530-pp6bl941 325 4 emphasized emphasize VBN cord-302530-pp6bl941 325 5 that that IN cord-302530-pp6bl941 325 6 the the DT cord-302530-pp6bl941 325 7 estimate estimate NN cord-302530-pp6bl941 325 8 of of IN cord-302530-pp6bl941 325 9 8 8 CD cord-302530-pp6bl941 325 10 or or CC cord-302530-pp6bl941 325 11 9 9 CD cord-302530-pp6bl941 325 12 HA HA NNP cord-302530-pp6bl941 325 13 trimers trimer NNS cord-302530-pp6bl941 325 14 in in IN cord-302530-pp6bl941 325 15 Yang Yang NNP cord-302530-pp6bl941 325 16 et et NNP cord-302530-pp6bl941 325 17 al al NNP cord-302530-pp6bl941 325 18 . . . cord-302530-pp6bl941 326 1 ( ( -LRB- cord-302530-pp6bl941 326 2 2005 2005 CD cord-302530-pp6bl941 326 3 ) ) -RRB- cord-302530-pp6bl941 326 4 is be VBZ cord-302530-pp6bl941 326 5 based base VBN cord-302530-pp6bl941 326 6 on on IN cord-302530-pp6bl941 326 7 a a DT cord-302530-pp6bl941 326 8 number number NN cord-302530-pp6bl941 326 9 of of IN cord-302530-pp6bl941 326 10 assumptions assumption NNS cord-302530-pp6bl941 326 11 that that WDT cord-302530-pp6bl941 326 12 may may MD cord-302530-pp6bl941 326 13 not not RB cord-302530-pp6bl941 326 14 hold hold VB cord-302530-pp6bl941 326 15 , , , cord-302530-pp6bl941 326 16 for for IN cord-302530-pp6bl941 326 17 example example NN cord-302530-pp6bl941 326 18 whereas whereas IN cord-302530-pp6bl941 326 19 each each DT cord-302530-pp6bl941 326 20 infection infection NN cord-302530-pp6bl941 326 21 of of IN cord-302530-pp6bl941 326 22 a a DT cord-302530-pp6bl941 326 23 cell cell NN cord-302530-pp6bl941 326 24 is be VBZ cord-302530-pp6bl941 326 25 a a DT cord-302530-pp6bl941 326 26 quantal quantal JJ cord-302530-pp6bl941 326 27 , , , cord-302530-pp6bl941 326 28 all all RB cord-302530-pp6bl941 326 29 - - HYPH cord-302530-pp6bl941 326 30 or or CC cord-302530-pp6bl941 326 31 - - HYPH cord-302530-pp6bl941 326 32 nothing nothing NN cord-302530-pp6bl941 326 33 event event NN cord-302530-pp6bl941 326 34 , , , cord-302530-pp6bl941 326 35 the the DT cord-302530-pp6bl941 326 36 infectivity infectivity NN cord-302530-pp6bl941 326 37 of of IN cord-302530-pp6bl941 326 38 a a DT cord-302530-pp6bl941 326 39 virion virion NN cord-302530-pp6bl941 326 40 could could MD cord-302530-pp6bl941 326 41 span span VB cord-302530-pp6bl941 326 42 a a DT cord-302530-pp6bl941 326 43 wide wide JJ cord-302530-pp6bl941 326 44 spectrum spectrum NN cord-302530-pp6bl941 326 45 of of IN cord-302530-pp6bl941 326 46 propensities propensity NNS cord-302530-pp6bl941 326 47 and and CC cord-302530-pp6bl941 326 48 each each DT cord-302530-pp6bl941 326 49 mathematical mathematical JJ cord-302530-pp6bl941 326 50 model model NN cord-302530-pp6bl941 326 51 could could MD cord-302530-pp6bl941 326 52 have have VB cord-302530-pp6bl941 326 53 different different JJ cord-302530-pp6bl941 326 54 virological virological JJ cord-302530-pp6bl941 326 55 interpretations interpretation NNS cord-302530-pp6bl941 326 56 ( ( -LRB- cord-302530-pp6bl941 326 57 see see VB cord-302530-pp6bl941 326 58 Klasse Klasse NNP cord-302530-pp6bl941 326 59 2012 2012 CD cord-302530-pp6bl941 326 60 ) ) -RRB- cord-302530-pp6bl941 326 61 . . . cord-302530-pp6bl941 327 1 However however RB cord-302530-pp6bl941 327 2 , , , cord-302530-pp6bl941 327 3 in in IN cord-302530-pp6bl941 327 4 the the DT cord-302530-pp6bl941 327 5 absence absence NN cord-302530-pp6bl941 327 6 of of IN cord-302530-pp6bl941 327 7 any any DT cord-302530-pp6bl941 327 8 data datum NNS cord-302530-pp6bl941 327 9 for for IN cord-302530-pp6bl941 327 10 ΔS ΔS NNP cord-302530-pp6bl941 327 11 a_immob a_immob NNP cord-302530-pp6bl941 327 12 the the DT cord-302530-pp6bl941 327 13 value value NN cord-302530-pp6bl941 327 14 of of IN cord-302530-pp6bl941 327 15 n n NN cord-302530-pp6bl941 327 16 from from IN cord-302530-pp6bl941 327 17 Yang Yang NNP cord-302530-pp6bl941 327 18 et et NNP cord-302530-pp6bl941 327 19 al al NNP cord-302530-pp6bl941 327 20 . . . cord-302530-pp6bl941 328 1 ( ( -LRB- cord-302530-pp6bl941 328 2 2005 2005 CD cord-302530-pp6bl941 328 3 ) ) -RRB- cord-302530-pp6bl941 328 4 at at IN cord-302530-pp6bl941 328 5 least least JJS cord-302530-pp6bl941 328 6 provides provide VBZ cord-302530-pp6bl941 328 7 a a DT cord-302530-pp6bl941 328 8 theoretical theoretical JJ cord-302530-pp6bl941 328 9 approach approach NN cord-302530-pp6bl941 328 10 to to TO cord-302530-pp6bl941 328 11 estimate estimate VB cord-302530-pp6bl941 328 12 it -PRON- PRP cord-302530-pp6bl941 328 13 from from IN cord-302530-pp6bl941 328 14 Eq Eq NNP cord-302530-pp6bl941 328 15 . . . cord-302530-pp6bl941 329 1 ( ( -LRB- cord-302530-pp6bl941 329 2 17 17 CD cord-302530-pp6bl941 329 3 ) ) -RRB- cord-302530-pp6bl941 329 4 for for IN cord-302530-pp6bl941 329 5 this this DT cord-302530-pp6bl941 329 6 " " `` cord-302530-pp6bl941 329 7 proof proof NN cord-302530-pp6bl941 329 8 of of IN cord-302530-pp6bl941 329 9 concept concept NN cord-302530-pp6bl941 329 10 " " '' cord-302530-pp6bl941 329 11 model model NN cord-302530-pp6bl941 329 12 . . . cord-302530-pp6bl941 330 1 It -PRON- PRP cord-302530-pp6bl941 330 2 was be VBD cord-302530-pp6bl941 330 3 shown show VBN cord-302530-pp6bl941 330 4 previously previously RB cord-302530-pp6bl941 330 5 ( ( -LRB- cord-302530-pp6bl941 330 6 Gale Gale NNP cord-302530-pp6bl941 330 7 2019 2019 CD cord-302530-pp6bl941 330 8 ) ) -RRB- cord-302530-pp6bl941 330 9 that that WDT cord-302530-pp6bl941 330 10 ΔS ΔS NNP cord-302530-pp6bl941 330 11 a_immob a_immob NNP cord-302530-pp6bl941 330 12 is be VBZ cord-302530-pp6bl941 330 13 the the DT cord-302530-pp6bl941 330 14 sum sum NN cord-302530-pp6bl941 330 15 of of IN cord-302530-pp6bl941 330 16 the the DT cord-302530-pp6bl941 330 17 changes change NNS cord-302530-pp6bl941 330 18 in in IN cord-302530-pp6bl941 330 19 translational translational JJ cord-302530-pp6bl941 330 20 entropy entropy NN cord-302530-pp6bl941 330 21 ( ( -LRB- cord-302530-pp6bl941 330 22 ΔS ΔS NNP cord-302530-pp6bl941 330 23 trans trans NNP cord-302530-pp6bl941 330 24 ) ) -RRB- cord-302530-pp6bl941 330 25 and and CC cord-302530-pp6bl941 330 26 rotational rotational JJ cord-302530-pp6bl941 330 27 entropy entropy NN cord-302530-pp6bl941 330 28 ( ( -LRB- cord-302530-pp6bl941 330 29 ΔS ΔS NNP cord-302530-pp6bl941 330 30 rot rot VB cord-302530-pp6bl941 330 31 ) ) -RRB- cord-302530-pp6bl941 330 32 of of IN cord-302530-pp6bl941 330 33 the the DT cord-302530-pp6bl941 330 34 whole whole JJ cord-302530-pp6bl941 330 35 virus virus NN cord-302530-pp6bl941 330 36 on on IN cord-302530-pp6bl941 330 37 binding bind VBG cord-302530-pp6bl941 330 38 . . . cord-302530-pp6bl941 331 1 According accord VBG cord-302530-pp6bl941 331 2 to to IN cord-302530-pp6bl941 331 3 Mammen Mammen NNP cord-302530-pp6bl941 331 4 et et NNP cord-302530-pp6bl941 331 5 al al NNP cord-302530-pp6bl941 331 6 . . . cord-302530-pp6bl941 332 1 ( ( -LRB- cord-302530-pp6bl941 332 2 1998 1998 CD cord-302530-pp6bl941 332 3 ) ) -RRB- cord-302530-pp6bl941 333 1 ΔS ΔS NNP cord-302530-pp6bl941 333 2 trans trans NNP cord-302530-pp6bl941 333 3 ∝ ∝ NNP cord-302530-pp6bl941 334 1 ln(Mass ln(mass LS cord-302530-pp6bl941 334 2 ) ) -RRB- cord-302530-pp6bl941 335 1 and and CC cord-302530-pp6bl941 335 2 ΔS ΔS NNP cord-302530-pp6bl941 335 3 rot rot VB cord-302530-pp6bl941 335 4 ∝ ∝ NNP cord-302530-pp6bl941 335 5 ln(I ln(I NNP cord-302530-pp6bl941 336 1 x x LS cord-302530-pp6bl941 337 1 x x LS cord-302530-pp6bl941 338 1 I -PRON- PRP cord-302530-pp6bl941 339 1 y y NNP cord-302530-pp6bl941 340 1 x x LS cord-302530-pp6bl941 341 1 I -PRON- PRP cord-302530-pp6bl941 341 2 z z LS cord-302530-pp6bl941 341 3 ) ) -RRB- cord-302530-pp6bl941 342 1 where where WRB cord-302530-pp6bl941 342 2 I -PRON- PRP cord-302530-pp6bl941 342 3 x x VBP cord-302530-pp6bl941 342 4 , , , cord-302530-pp6bl941 342 5 I -PRON- PRP cord-302530-pp6bl941 342 6 y y NNP cord-302530-pp6bl941 342 7 and and CC cord-302530-pp6bl941 343 1 I -PRON- PRP cord-302530-pp6bl941 343 2 z z NNP cord-302530-pp6bl941 343 3 are be VBP cord-302530-pp6bl941 343 4 the the DT cord-302530-pp6bl941 343 5 moments moment NNS cord-302530-pp6bl941 343 6 of of IN cord-302530-pp6bl941 343 7 inertia inertia NN cord-302530-pp6bl941 343 8 about about IN cord-302530-pp6bl941 343 9 the the DT cord-302530-pp6bl941 343 10 three three CD cord-302530-pp6bl941 343 11 principle principle JJ cord-302530-pp6bl941 343 12 axes axis NNS cord-302530-pp6bl941 343 13 of of IN cord-302530-pp6bl941 343 14 rotation rotation NN cord-302530-pp6bl941 343 15 . . . cord-302530-pp6bl941 344 1 Since since IN cord-302530-pp6bl941 344 2 mass mass NN cord-302530-pp6bl941 344 3 , , , cord-302530-pp6bl941 344 4 M M NNP cord-302530-pp6bl941 344 5 , , , cord-302530-pp6bl941 344 6 is be VBZ cord-302530-pp6bl941 344 7 proportional proportional JJ cord-302530-pp6bl941 344 8 to to IN cord-302530-pp6bl941 344 9 the the DT cord-302530-pp6bl941 344 10 volume volume NN cord-302530-pp6bl941 345 1 and and CC cord-302530-pp6bl941 345 2 I i NN cord-302530-pp6bl941 345 3 = = : cord-302530-pp6bl941 345 4 Mr Mr NNP cord-302530-pp6bl941 345 5 2 2 CD cord-302530-pp6bl941 345 6 where where WRB cord-302530-pp6bl941 345 7 r r NNP cord-302530-pp6bl941 345 8 is be VBZ cord-302530-pp6bl941 345 9 the the DT cord-302530-pp6bl941 345 10 radius radius NN cord-302530-pp6bl941 345 11 of of IN cord-302530-pp6bl941 345 12 the the DT cord-302530-pp6bl941 345 13 virus virus NN cord-302530-pp6bl941 345 14 , , , cord-302530-pp6bl941 345 15 it -PRON- PRP cord-302530-pp6bl941 345 16 may may MD cord-302530-pp6bl941 345 17 be be VB cord-302530-pp6bl941 345 18 shown show VBN cord-302530-pp6bl941 345 19 that that IN cord-302530-pp6bl941 345 20 the the DT cord-302530-pp6bl941 345 21 decrease decrease NN cord-302530-pp6bl941 345 22 in in IN cord-302530-pp6bl941 345 23 entropy entropy NN cord-302530-pp6bl941 345 24 on on IN cord-302530-pp6bl941 345 25 immobilisation immobilisation NN cord-302530-pp6bl941 345 26 ( ( -LRB- cord-302530-pp6bl941 345 27 ΔS ΔS NNP cord-302530-pp6bl941 345 28 a_immob a_immob NNP cord-302530-pp6bl941 345 29 ) ) -RRB- cord-302530-pp6bl941 345 30 of of IN cord-302530-pp6bl941 345 31 a a DT cord-302530-pp6bl941 345 32 spherical spherical JJ cord-302530-pp6bl941 345 33 virus virus NN cord-302530-pp6bl941 345 34 can can MD cord-302530-pp6bl941 345 35 be be VB cord-302530-pp6bl941 345 36 expressed express VBN cord-302530-pp6bl941 345 37 as as IN cord-302530-pp6bl941 345 38 Eq Eq NNP cord-302530-pp6bl941 345 39 . . . cord-302530-pp6bl941 346 1 ( ( -LRB- cord-302530-pp6bl941 346 2 18 18 CD cord-302530-pp6bl941 346 3 ) ) -RRB- cord-302530-pp6bl941 346 4 . . . cord-302530-pp6bl941 347 1 Examples example NNS cord-302530-pp6bl941 347 2 of of IN cord-302530-pp6bl941 347 3 diameters diameter NNS cord-302530-pp6bl941 347 4 for for IN cord-302530-pp6bl941 347 5 arboviruses arbovirus NNS cord-302530-pp6bl941 347 6 are~50 are~50 CD cord-302530-pp6bl941 347 7 nm nm NN cord-302530-pp6bl941 347 8 for for IN cord-302530-pp6bl941 347 9 WNV WNV NNP cord-302530-pp6bl941 348 1 ( ( -LRB- cord-302530-pp6bl941 348 2 Mukhopadhyay Mukhopadhyay NNP cord-302530-pp6bl941 348 3 et et NNP cord-302530-pp6bl941 348 4 al al NNP cord-302530-pp6bl941 348 5 . . NNP cord-302530-pp6bl941 348 6 , , , cord-302530-pp6bl941 348 7 2003 2003 CD cord-302530-pp6bl941 348 8 ) ) -RRB- cord-302530-pp6bl941 348 9 and and CC cord-302530-pp6bl941 348 10 DENV DENV NNP cord-302530-pp6bl941 348 11 , , , cord-302530-pp6bl941 348 12 66 66 CD cord-302530-pp6bl941 348 13 nm nm NN cord-302530-pp6bl941 348 14 for for IN cord-302530-pp6bl941 348 15 Eastern eastern JJ cord-302530-pp6bl941 348 16 equine equine JJ cord-302530-pp6bl941 348 17 encephalitis encephalitis NN cord-302530-pp6bl941 348 18 virus virus NN cord-302530-pp6bl941 348 19 ( ( -LRB- cord-302530-pp6bl941 348 20 Hasan Hasan NNP cord-302530-pp6bl941 348 21 et et NNP cord-302530-pp6bl941 348 22 al al NNP cord-302530-pp6bl941 348 23 . . NNP cord-302530-pp6bl941 348 24 , , , cord-302530-pp6bl941 348 25 2018 2018 CD cord-302530-pp6bl941 348 26 ) ) -RRB- cord-302530-pp6bl941 348 27 with with IN cord-302530-pp6bl941 348 28 BTV BTV NNP cord-302530-pp6bl941 348 29 being be VBG cord-302530-pp6bl941 348 30 slightly slightly RB cord-302530-pp6bl941 348 31 larger large JJR cord-302530-pp6bl941 348 32 at at IN cord-302530-pp6bl941 348 33 85 85 CD cord-302530-pp6bl941 348 34 nm nm NN cord-302530-pp6bl941 349 1 ( ( -LRB- cord-302530-pp6bl941 349 2 Nason Nason NNP cord-302530-pp6bl941 349 3 et et NNP cord-302530-pp6bl941 349 4 al al NNP cord-302530-pp6bl941 349 5 . . NNP cord-302530-pp6bl941 349 6 , , , cord-302530-pp6bl941 349 7 2004 2004 CD cord-302530-pp6bl941 349 8 ) ) -RRB- cord-302530-pp6bl941 349 9 . . . cord-302530-pp6bl941 350 1 In in IN cord-302530-pp6bl941 350 2 contrast contrast NN cord-302530-pp6bl941 350 3 , , , cord-302530-pp6bl941 350 4 HIV HIV NNP cord-302530-pp6bl941 350 5 is be VBZ cord-302530-pp6bl941 350 6 much much RB cord-302530-pp6bl941 350 7 larger large JJR cord-302530-pp6bl941 350 8 with with IN cord-302530-pp6bl941 350 9 a a DT cord-302530-pp6bl941 350 10 mean mean JJ cord-302530-pp6bl941 350 11 diameter diameter NN cord-302530-pp6bl941 350 12 of of IN cord-302530-pp6bl941 350 13 134 134 CD cord-302530-pp6bl941 350 14 nm nm NN cord-302530-pp6bl941 350 15 in in IN cord-302530-pp6bl941 350 16 the the DT cord-302530-pp6bl941 350 17 case case NN cord-302530-pp6bl941 350 18 of of IN cord-302530-pp6bl941 350 19 mature mature JJ cord-302530-pp6bl941 350 20 HIV HIV NNP cord-302530-pp6bl941 350 21 virions virion NNS cord-302530-pp6bl941 350 22 containing contain VBG cord-302530-pp6bl941 350 23 a a DT cord-302530-pp6bl941 350 24 single single JJ cord-302530-pp6bl941 350 25 core core NN cord-302530-pp6bl941 350 26 ( ( -LRB- cord-302530-pp6bl941 350 27 Briggs Briggs NNP cord-302530-pp6bl941 350 28 et et NNP cord-302530-pp6bl941 350 29 al al NNP cord-302530-pp6bl941 350 30 . . NNP cord-302530-pp6bl941 350 31 , , , cord-302530-pp6bl941 350 32 2003 2003 CD cord-302530-pp6bl941 350 33 ) ) -RRB- cord-302530-pp6bl941 350 34 . . . cord-302530-pp6bl941 351 1 The the DT cord-302530-pp6bl941 351 2 problem problem NN cord-302530-pp6bl941 351 3 with with IN cord-302530-pp6bl941 351 4 Eq Eq NNP cord-302530-pp6bl941 351 5 . . . cord-302530-pp6bl941 352 1 ( ( -LRB- cord-302530-pp6bl941 352 2 18 18 CD cord-302530-pp6bl941 352 3 ) ) -RRB- cord-302530-pp6bl941 352 4 is be VBZ cord-302530-pp6bl941 352 5 that that DT cord-302530-pp6bl941 352 6 Fig Fig NNP cord-302530-pp6bl941 352 7 . . . cord-302530-pp6bl941 353 1 4 4 LS cord-302530-pp6bl941 353 2 . . . cord-302530-pp6bl941 354 1 Temperature temperature JJ cord-302530-pp6bl941 354 2 variation variation NN cord-302530-pp6bl941 354 3 of of IN cord-302530-pp6bl941 354 4 a a DT cord-302530-pp6bl941 354 5 ) ) -RRB- cord-302530-pp6bl941 354 6 and and CC cord-302530-pp6bl941 354 7 c c LS cord-302530-pp6bl941 354 8 ) ) -RRB- cord-302530-pp6bl941 354 9 K K NNP cord-302530-pp6bl941 354 10 a_virus_T a_virus_T NNP cord-302530-pp6bl941 354 11 and and CC cord-302530-pp6bl941 354 12 b b LS cord-302530-pp6bl941 354 13 ) ) -RRB- cord-302530-pp6bl941 354 14 and and CC cord-302530-pp6bl941 354 15 d d LS cord-302530-pp6bl941 354 16 ) ) -RRB- cord-302530-pp6bl941 354 17 number number NN cord-302530-pp6bl941 354 18 , , , cord-302530-pp6bl941 354 19 C.V C.V NNP cord-302530-pp6bl941 354 20 T T NNP cord-302530-pp6bl941 354 21 , , , cord-302530-pp6bl941 354 22 of of IN cord-302530-pp6bl941 354 23 CD4 CD4 NNP cord-302530-pp6bl941 354 24 + + CC cord-302530-pp6bl941 354 25 T t NN cord-302530-pp6bl941 354 26 cells cell NNS cord-302530-pp6bl941 354 27 per per IN cord-302530-pp6bl941 354 28 mm mm NN cord-302530-pp6bl941 354 29 3 3 CD cord-302530-pp6bl941 354 30 blood blood NN cord-302530-pp6bl941 354 31 with with IN cord-302530-pp6bl941 354 32 bound bind VBN cord-302530-pp6bl941 354 33 HIV HIV NNP cord-302530-pp6bl941 354 34 virions virion NNS cord-302530-pp6bl941 354 35 in in IN cord-302530-pp6bl941 354 36 HIV HIV NNP cord-302530-pp6bl941 354 37 model model NN cord-302530-pp6bl941 354 38 for for IN cord-302530-pp6bl941 354 39 ΔC ΔC NNP cord-302530-pp6bl941 354 40 p p NN cord-302530-pp6bl941 354 41 = = SYM cord-302530-pp6bl941 354 42 0 0 NFP cord-302530-pp6bl941 354 43 ( ( -LRB- cord-302530-pp6bl941 354 44 solid solid JJ cord-302530-pp6bl941 354 45 line line NN cord-302530-pp6bl941 354 46 ) ) -RRB- cord-302530-pp6bl941 354 47 , , , cord-302530-pp6bl941 354 48 −1.97 −1.97 NNP cord-302530-pp6bl941 354 49 ( ( -LRB- cord-302530-pp6bl941 354 50 dotted dotted JJ cord-302530-pp6bl941 354 51 line line NN cord-302530-pp6bl941 354 52 ) ) -RRB- cord-302530-pp6bl941 354 53 and and CC cord-302530-pp6bl941 354 54 −5.02 −5.02 NNP cord-302530-pp6bl941 355 1 ( ( -LRB- cord-302530-pp6bl941 355 2 dashed dash VBN cord-302530-pp6bl941 355 3 line line NN cord-302530-pp6bl941 355 4 ) ) -RRB- cord-302530-pp6bl941 356 1 kJ kJ NNP cord-302530-pp6bl941 357 1 /mol/ /mol/ CC cord-302530-pp6bl941 357 2 K K NNP cord-302530-pp6bl941 357 3 ( ( -LRB- cord-302530-pp6bl941 357 4 Table Table NNP cord-302530-pp6bl941 357 5 3 3 CD cord-302530-pp6bl941 357 6 ) ) -RRB- cord-302530-pp6bl941 357 7 and and CC cord-302530-pp6bl941 357 8 thermodynamic thermodynamic JJ cord-302530-pp6bl941 357 9 parameters parameter NNS cord-302530-pp6bl941 357 10 for for IN cord-302530-pp6bl941 357 11 n n NN cord-302530-pp6bl941 357 12 = = SYM cord-302530-pp6bl941 357 13 3 3 CD cord-302530-pp6bl941 357 14 HIV HIV NNP cord-302530-pp6bl941 357 15 Env Env NNP cord-302530-pp6bl941 357 16 : : : cord-302530-pp6bl941 358 1 CD4 CD4 NNP cord-302530-pp6bl941 358 2 interactions interaction NNS cord-302530-pp6bl941 358 3 in in IN cord-302530-pp6bl941 358 4 Table Table NNP cord-302530-pp6bl941 358 5 4 4 CD cord-302530-pp6bl941 358 6 at at IN cord-302530-pp6bl941 358 7 reference reference NN cord-302530-pp6bl941 358 8 temperature temperature NN cord-302530-pp6bl941 358 9 a a DT cord-302530-pp6bl941 358 10 ) ) -RRB- cord-302530-pp6bl941 358 11 and and CC cord-302530-pp6bl941 358 12 b b LS cord-302530-pp6bl941 358 13 ) ) -RRB- cord-302530-pp6bl941 358 14 T t NN cord-302530-pp6bl941 358 15 0 0 CD cord-302530-pp6bl941 358 16 = = NFP cord-302530-pp6bl941 359 1 37 37 CD cord-302530-pp6bl941 359 2 ° ° NN cord-302530-pp6bl941 359 3 C c NN cord-302530-pp6bl941 359 4 ; ; : cord-302530-pp6bl941 359 5 c c NNP cord-302530-pp6bl941 359 6 ) ) -RRB- cord-302530-pp6bl941 359 7 and and CC cord-302530-pp6bl941 359 8 d d LS cord-302530-pp6bl941 359 9 ) ) -RRB- cord-302530-pp6bl941 359 10 T t NN cord-302530-pp6bl941 359 11 0 0 CD cord-302530-pp6bl941 359 12 = = SYM cord-302530-pp6bl941 359 13 4 4 CD cord-302530-pp6bl941 359 14 ° ° NN cord-302530-pp6bl941 359 15 C c NN cord-302530-pp6bl941 359 16 . . . cord-302530-pp6bl941 360 1 ΔS ΔS NNP cord-302530-pp6bl941 360 2 a_immob a_immob NNP cord-302530-pp6bl941 361 1 = = NFP cord-302530-pp6bl941 362 1 −400 −400 NNP cord-302530-pp6bl941 362 2 J J NNP cord-302530-pp6bl941 362 3 / / SYM cord-302530-pp6bl941 362 4 mol mol NNP cord-302530-pp6bl941 362 5 / / SYM cord-302530-pp6bl941 362 6 K. K. NNP cord-302530-pp6bl941 362 7 proportionality proportionality NN cord-302530-pp6bl941 362 8 constants constant NNS cord-302530-pp6bl941 362 9 in in IN cord-302530-pp6bl941 362 10 units unit NNS cord-302530-pp6bl941 362 11 of of IN cord-302530-pp6bl941 362 12 J J NNP cord-302530-pp6bl941 362 13 / / SYM cord-302530-pp6bl941 362 14 mol mol NNP cord-302530-pp6bl941 362 15 / / SYM cord-302530-pp6bl941 362 16 K K NNP cord-302530-pp6bl941 362 17 are be VBP cord-302530-pp6bl941 362 18 needed need VBN cord-302530-pp6bl941 362 19 probably probably RB cord-302530-pp6bl941 362 20 based base VBN cord-302530-pp6bl941 362 21 on on IN cord-302530-pp6bl941 362 22 R r NN cord-302530-pp6bl941 362 23 as as IN cord-302530-pp6bl941 362 24 in in IN cord-302530-pp6bl941 362 25 the the DT cord-302530-pp6bl941 362 26 Sackur Sackur NNP cord-302530-pp6bl941 362 27 - - HYPH cord-302530-pp6bl941 362 28 Tetrode Tetrode NNP cord-302530-pp6bl941 362 29 equation equation NN cord-302530-pp6bl941 362 30 and and CC cord-302530-pp6bl941 362 31 the the DT cord-302530-pp6bl941 362 32 natural natural JJ cord-302530-pp6bl941 362 33 logarithm logarithm NN cord-302530-pp6bl941 362 34 terms term NNS cord-302530-pp6bl941 363 1 should should MD cord-302530-pp6bl941 363 2 be be VB cord-302530-pp6bl941 363 3 dimensionless dimensionless JJ cord-302530-pp6bl941 363 4 such such JJ cord-302530-pp6bl941 363 5 that that IN cord-302530-pp6bl941 363 6 the the DT cord-302530-pp6bl941 363 7 units unit NNS cord-302530-pp6bl941 363 8 of of IN cord-302530-pp6bl941 363 9 radius radius NN cord-302530-pp6bl941 363 10 cancel cancel VBP cord-302530-pp6bl941 363 11 out out RP cord-302530-pp6bl941 363 12 . . . cord-302530-pp6bl941 364 1 However however RB cord-302530-pp6bl941 364 2 for for IN cord-302530-pp6bl941 364 3 the the DT cord-302530-pp6bl941 364 4 purpose purpose NN cord-302530-pp6bl941 364 5 of of IN cord-302530-pp6bl941 364 6 representing represent VBG cord-302530-pp6bl941 364 7 the the DT cord-302530-pp6bl941 364 8 effect effect NN cord-302530-pp6bl941 364 9 of of IN cord-302530-pp6bl941 364 10 increasing increase VBG cord-302530-pp6bl941 364 11 the the DT cord-302530-pp6bl941 364 12 radius radius NN cord-302530-pp6bl941 364 13 of of IN cord-302530-pp6bl941 364 14 the the DT cord-302530-pp6bl941 364 15 virus virus NN cord-302530-pp6bl941 364 16 on on IN cord-302530-pp6bl941 364 17 ΔS ΔS NNP cord-302530-pp6bl941 364 18 a_immob a_immob NNP cord-302530-pp6bl941 364 19 Eq Eq NNP cord-302530-pp6bl941 364 20 . . . cord-302530-pp6bl941 365 1 ( ( -LRB- cord-302530-pp6bl941 365 2 18 18 CD cord-302530-pp6bl941 365 3 ) ) -RRB- cord-302530-pp6bl941 365 4 is be VBZ cord-302530-pp6bl941 365 5 used use VBN cord-302530-pp6bl941 365 6 with with IN cord-302530-pp6bl941 365 7 the the DT cord-302530-pp6bl941 365 8 virus virus NN cord-302530-pp6bl941 365 9 radius radius NN cord-302530-pp6bl941 365 10 in in IN cord-302530-pp6bl941 365 11 units unit NNS cord-302530-pp6bl941 365 12 of of IN cord-302530-pp6bl941 365 13 nm nm NN cord-302530-pp6bl941 365 14 . . . cord-302530-pp6bl941 366 1 Thus thus RB cord-302530-pp6bl941 366 2 from from IN cord-302530-pp6bl941 366 3 Eq Eq NNP cord-302530-pp6bl941 366 4 . . . cord-302530-pp6bl941 367 1 ( ( -LRB- cord-302530-pp6bl941 367 2 18 18 CD cord-302530-pp6bl941 367 3 ) ) -RRB- cord-302530-pp6bl941 367 4 , , , cord-302530-pp6bl941 367 5 the the DT cord-302530-pp6bl941 367 6 magnitude magnitude NN cord-302530-pp6bl941 367 7 of of IN cord-302530-pp6bl941 367 8 ΔS ΔS NNP cord-302530-pp6bl941 367 9 a_immob a_immob NNP cord-302530-pp6bl941 367 10 for for IN cord-302530-pp6bl941 367 11 a a DT cord-302530-pp6bl941 367 12 virus virus NN cord-302530-pp6bl941 367 13 of of IN cord-302530-pp6bl941 367 14 diameter diameter NN cord-302530-pp6bl941 367 15 134 134 CD cord-302530-pp6bl941 367 16 nm nm NN cord-302530-pp6bl941 367 17 is be VBZ cord-302530-pp6bl941 367 18 18.6 18.6 CD cord-302530-pp6bl941 367 19 % % NN cord-302530-pp6bl941 367 20 more more RBR cord-302530-pp6bl941 367 21 negative negative JJ cord-302530-pp6bl941 367 22 than than IN cord-302530-pp6bl941 367 23 that that DT cord-302530-pp6bl941 367 24 for for IN cord-302530-pp6bl941 367 25 a a DT cord-302530-pp6bl941 367 26 virus virus NN cord-302530-pp6bl941 367 27 of of IN cord-302530-pp6bl941 367 28 diameter diameter NN cord-302530-pp6bl941 367 29 66 66 CD cord-302530-pp6bl941 367 30 nm nm NN cord-302530-pp6bl941 367 31 . . . cord-302530-pp6bl941 368 1 To to TO cord-302530-pp6bl941 368 2 illustrate illustrate VB cord-302530-pp6bl941 368 3 the the DT cord-302530-pp6bl941 368 4 effect effect NN cord-302530-pp6bl941 368 5 of of IN cord-302530-pp6bl941 368 6 increasing increase VBG cord-302530-pp6bl941 368 7 virus virus NN cord-302530-pp6bl941 368 8 size size NN cord-302530-pp6bl941 368 9 on on IN cord-302530-pp6bl941 368 10 the the DT cord-302530-pp6bl941 368 11 number number NN cord-302530-pp6bl941 368 12 of of IN cord-302530-pp6bl941 368 13 CD4 CD4 NNP cord-302530-pp6bl941 368 14 + + CC cord-302530-pp6bl941 368 15 T T NNP cord-302530-pp6bl941 368 16 cells cell NNS cord-302530-pp6bl941 368 17 in in IN cord-302530-pp6bl941 368 18 1 1 CD cord-302530-pp6bl941 368 19 mm mm CD cord-302530-pp6bl941 368 20 3 3 CD cord-302530-pp6bl941 368 21 of of IN cord-302530-pp6bl941 368 22 blood blood NN cord-302530-pp6bl941 368 23 with with IN cord-302530-pp6bl941 368 24 bound bind VBN cord-302530-pp6bl941 368 25 virus virus NN cord-302530-pp6bl941 368 26 , , , cord-302530-pp6bl941 368 27 C.V C.V NNP cord-302530-pp6bl941 368 28 T T NNP cord-302530-pp6bl941 368 29 is be VBZ cord-302530-pp6bl941 368 30 calculated calculate VBN cord-302530-pp6bl941 368 31 for for IN cord-302530-pp6bl941 368 32 the the DT cord-302530-pp6bl941 368 33 HIV HIV NNP cord-302530-pp6bl941 368 34 model model NN cord-302530-pp6bl941 368 35 using use VBG cord-302530-pp6bl941 368 36 values value NNS cord-302530-pp6bl941 368 37 of of IN cord-302530-pp6bl941 368 38 ΔS ΔS NNP cord-302530-pp6bl941 368 39 a_immob a_immob NNP cord-302530-pp6bl941 368 40 which which WDT cord-302530-pp6bl941 368 41 decrease decrease VBP cord-302530-pp6bl941 368 42 in in IN cord-302530-pp6bl941 368 43 steps step NNS cord-302530-pp6bl941 368 44 of of IN cord-302530-pp6bl941 368 45 18.6 18.6 CD cord-302530-pp6bl941 368 46 % % NN cord-302530-pp6bl941 368 47 from from IN cord-302530-pp6bl941 368 48 −240 −240 NNP cord-302530-pp6bl941 368 49 J J NNP cord-302530-pp6bl941 368 50 / / SYM cord-302530-pp6bl941 368 51 mol mol NNP cord-302530-pp6bl941 368 52 / / SYM cord-302530-pp6bl941 368 53 K K NNP cord-302530-pp6bl941 368 54 ( ( -LRB- cord-302530-pp6bl941 368 55 i.e. i.e. FW cord-302530-pp6bl941 368 56 to to IN cord-302530-pp6bl941 368 57 −285 −285 NNP cord-302530-pp6bl941 368 58 J J NNP cord-302530-pp6bl941 368 59 / / SYM cord-302530-pp6bl941 368 60 mol mol NNP cord-302530-pp6bl941 368 61 / / SYM cord-302530-pp6bl941 368 62 K K NNP cord-302530-pp6bl941 368 63 , , , cord-302530-pp6bl941 369 1 −337 −337 NNP cord-302530-pp6bl941 369 2 J/ J/ NNP cord-302530-pp6bl941 369 3 Mol Mol NNP cord-302530-pp6bl941 369 4 / / SYM cord-302530-pp6bl941 369 5 K K NNP cord-302530-pp6bl941 369 6 and and CC cord-302530-pp6bl941 369 7 −400 −400 NNP cord-302530-pp6bl941 369 8 J J NNP cord-302530-pp6bl941 369 9 / / SYM cord-302530-pp6bl941 369 10 mol mol NNP cord-302530-pp6bl941 369 11 / / SYM cord-302530-pp6bl941 369 12 K K NNP cord-302530-pp6bl941 369 13 ) ) -RRB- cord-302530-pp6bl941 369 14 . . . cord-302530-pp6bl941 370 1 2.7 2.7 CD cord-302530-pp6bl941 370 2 . . . cord-302530-pp6bl941 371 1 Case case NN cord-302530-pp6bl941 371 2 study study NN cord-302530-pp6bl941 371 3 5 5 CD cord-302530-pp6bl941 371 4 : : : cord-302530-pp6bl941 372 1 HIV HIV NNP cord-302530-pp6bl941 372 2 attachment attachment NN cord-302530-pp6bl941 372 3 factors factor NNS cord-302530-pp6bl941 372 4 may may MD cord-302530-pp6bl941 372 5 partially partially RB cord-302530-pp6bl941 372 6 overcome overcome VB cord-302530-pp6bl941 372 7 the the DT cord-302530-pp6bl941 372 8 unfavourable unfavourable JJ cord-302530-pp6bl941 372 9 ΔS ΔS NNP cord-302530-pp6bl941 372 10 a_immob a_immob NNP cord-302530-pp6bl941 372 11 and and CC cord-302530-pp6bl941 372 12 enhance enhance VB cord-302530-pp6bl941 372 13 specific specific JJ cord-302530-pp6bl941 372 14 virus virus NN cord-302530-pp6bl941 372 15 binding bind VBG cord-302530-pp6bl941 372 16 through through IN cord-302530-pp6bl941 372 17 Env Env NNP cord-302530-pp6bl941 372 18 / / SYM cord-302530-pp6bl941 372 19 CD4 CD4 NNP cord-302530-pp6bl941 372 20 interactions interaction NNS cord-302530-pp6bl941 372 21 at at IN cord-302530-pp6bl941 372 22 human human JJ cord-302530-pp6bl941 372 23 body body NN cord-302530-pp6bl941 372 24 temperature temperature NN cord-302530-pp6bl941 372 25 2.7.1 2.7.1 CD cord-302530-pp6bl941 372 26 . . . cord-302530-pp6bl941 373 1 Modelling model VBG cord-302530-pp6bl941 373 2 the the DT cord-302530-pp6bl941 373 3 effect effect NN cord-302530-pp6bl941 373 4 of of IN cord-302530-pp6bl941 373 5 non non JJ cord-302530-pp6bl941 373 6 - - JJ cord-302530-pp6bl941 373 7 specific specific JJ cord-302530-pp6bl941 373 8 binding binding NN cord-302530-pp6bl941 373 9 of of IN cord-302530-pp6bl941 373 10 HIV HIV NNP cord-302530-pp6bl941 373 11 to to TO cord-302530-pp6bl941 373 12 host host VB cord-302530-pp6bl941 373 13 CD4 CD4 NNP cord-302530-pp6bl941 373 14 + + CC cord-302530-pp6bl941 373 15 T t NN cord-302530-pp6bl941 373 16 cells cell NNS cord-302530-pp6bl941 373 17 prior prior RB cord-302530-pp6bl941 373 18 to to IN cord-302530-pp6bl941 373 19 specific specific JJ cord-302530-pp6bl941 373 20 Env env NN cord-302530-pp6bl941 373 21 : : : cord-302530-pp6bl941 373 22 CD4 CD4 NNP cord-302530-pp6bl941 373 23 interaction interaction NN cord-302530-pp6bl941 374 1 The the DT cord-302530-pp6bl941 374 2 term term NN cord-302530-pp6bl941 374 3 ΔS ΔS NNP cord-302530-pp6bl941 374 4 a_immob a_immob NNP cord-302530-pp6bl941 374 5 represents represent VBZ cord-302530-pp6bl941 374 6 the the DT cord-302530-pp6bl941 374 7 decrease decrease NN cord-302530-pp6bl941 374 8 in in IN cord-302530-pp6bl941 374 9 entropy entropy NN cord-302530-pp6bl941 374 10 of of IN cord-302530-pp6bl941 374 11 the the DT cord-302530-pp6bl941 374 12 virus virus NN cord-302530-pp6bl941 374 13 on on IN cord-302530-pp6bl941 374 14 going go VBG cord-302530-pp6bl941 374 15 from from IN cord-302530-pp6bl941 374 16 a a DT cord-302530-pp6bl941 374 17 freely freely RB cord-302530-pp6bl941 374 18 rotating rotate VBG cord-302530-pp6bl941 374 19 entity entity NN cord-302530-pp6bl941 374 20 to to IN cord-302530-pp6bl941 374 21 being be VBG cord-302530-pp6bl941 374 22 immobilised immobilise VBN cord-302530-pp6bl941 374 23 in in IN cord-302530-pp6bl941 374 24 a a DT cord-302530-pp6bl941 374 25 specific specific JJ cord-302530-pp6bl941 374 26 orientation orientation NN cord-302530-pp6bl941 374 27 on on IN cord-302530-pp6bl941 374 28 the the DT cord-302530-pp6bl941 374 29 host host NN cord-302530-pp6bl941 374 30 cell cell NN cord-302530-pp6bl941 374 31 surface surface NN cord-302530-pp6bl941 374 32 through through IN cord-302530-pp6bl941 374 33 n n NN cord-302530-pp6bl941 374 34 = = SYM cord-302530-pp6bl941 374 35 3 3 CD cord-302530-pp6bl941 374 36 specific specific JJ cord-302530-pp6bl941 374 37 Env env NN cord-302530-pp6bl941 374 38 : : : cord-302530-pp6bl941 374 39 CD4 CD4 NNP cord-302530-pp6bl941 374 40 interactions interaction NNS cord-302530-pp6bl941 374 41 . . . cord-302530-pp6bl941 375 1 Thermodynamically thermodynamically RB cord-302530-pp6bl941 375 2 this this DT cord-302530-pp6bl941 375 3 could could MD cord-302530-pp6bl941 375 4 be be VB cord-302530-pp6bl941 375 5 accomplished accomplish VBN cord-302530-pp6bl941 375 6 in in IN cord-302530-pp6bl941 375 7 two two CD cord-302530-pp6bl941 375 8 consecutive consecutive JJ cord-302530-pp6bl941 375 9 steps step NNS cord-302530-pp6bl941 375 10 whereby whereby WRB cord-302530-pp6bl941 375 11 the the DT cord-302530-pp6bl941 375 12 virus virus NN cord-302530-pp6bl941 375 13 first first RB cord-302530-pp6bl941 375 14 binds bind VBZ cord-302530-pp6bl941 375 15 non non AFX cord-302530-pp6bl941 375 16 - - NN cord-302530-pp6bl941 375 17 specifically specifically RB cord-302530-pp6bl941 375 18 to to IN cord-302530-pp6bl941 375 19 attachment attachment NN cord-302530-pp6bl941 375 20 proteins protein NNS cord-302530-pp6bl941 375 21 on on IN cord-302530-pp6bl941 375 22 the the DT cord-302530-pp6bl941 375 23 host host NN cord-302530-pp6bl941 375 24 cell cell NN cord-302530-pp6bl941 375 25 surface surface NN cord-302530-pp6bl941 375 26 with with IN cord-302530-pp6bl941 375 27 an an DT cord-302530-pp6bl941 375 28 entropy entropy NN cord-302530-pp6bl941 375 29 change change NN cord-302530-pp6bl941 375 30 of of IN cord-302530-pp6bl941 375 31 ΔS ΔS NNP cord-302530-pp6bl941 375 32 a_non_specific a_non_specific NNP cord-302530-pp6bl941 375 33 , , , cord-302530-pp6bl941 375 34 and and CC cord-302530-pp6bl941 375 35 then then RB cord-302530-pp6bl941 375 36 rolls roll VBZ cord-302530-pp6bl941 375 37 into into IN cord-302530-pp6bl941 375 38 place place NN cord-302530-pp6bl941 375 39 driven drive VBN cord-302530-pp6bl941 375 40 by by IN cord-302530-pp6bl941 375 41 n n NN cord-302530-pp6bl941 375 42 = = SYM cord-302530-pp6bl941 375 43 3 3 CD cord-302530-pp6bl941 375 44 specific specific JJ cord-302530-pp6bl941 375 45 Env env NN cord-302530-pp6bl941 375 46 : : : cord-302530-pp6bl941 376 1 CD4 CD4 NNP cord-302530-pp6bl941 376 2 interactions interaction NNS cord-302530-pp6bl941 376 3 resulting result VBG cord-302530-pp6bl941 376 4 in in IN cord-302530-pp6bl941 376 5 a a DT cord-302530-pp6bl941 376 6 further further JJ cord-302530-pp6bl941 376 7 entropy entropy NN cord-302530-pp6bl941 376 8 loss loss NN cord-302530-pp6bl941 376 9 ( ( -LRB- cord-302530-pp6bl941 376 10 ΔS ΔS NNP cord-302530-pp6bl941 376 11 a_specific a_specific NNP cord-302530-pp6bl941 376 12 ) ) -RRB- cord-302530-pp6bl941 376 13 as as IN cord-302530-pp6bl941 376 14 the the DT cord-302530-pp6bl941 376 15 virus virus NN cord-302530-pp6bl941 376 16 particle particle NN cord-302530-pp6bl941 376 17 takes take VBZ cord-302530-pp6bl941 376 18 up up RP cord-302530-pp6bl941 376 19 a a DT cord-302530-pp6bl941 376 20 specific specific JJ cord-302530-pp6bl941 376 21 orientation orientation NN cord-302530-pp6bl941 376 22 ready ready JJ cord-302530-pp6bl941 376 23 for for IN cord-302530-pp6bl941 376 24 viral viral JJ cord-302530-pp6bl941 376 25 entry entry NN cord-302530-pp6bl941 376 26 . . . cord-302530-pp6bl941 377 1 In in IN cord-302530-pp6bl941 377 2 effect effect NN cord-302530-pp6bl941 377 3 ΔS ΔS NNP cord-302530-pp6bl941 377 4 a_immob a_immob NNP cord-302530-pp6bl941 377 5 is be VBZ cord-302530-pp6bl941 377 6 the the DT cord-302530-pp6bl941 377 7 sum sum NN cord-302530-pp6bl941 377 8 of of IN cord-302530-pp6bl941 377 9 two two CD cord-302530-pp6bl941 377 10 components component NNS cord-302530-pp6bl941 377 11 , , , cord-302530-pp6bl941 377 12 namely namely RB cord-302530-pp6bl941 377 13 ΔS ΔS NNP cord-302530-pp6bl941 377 14 a_non_specific a_non_specific NNP cord-302530-pp6bl941 377 15 and and CC cord-302530-pp6bl941 377 16 ΔS ΔS NNP cord-302530-pp6bl941 377 17 a_specific a_specific NNP cord-302530-pp6bl941 377 18 according accord VBG cord-302530-pp6bl941 377 19 to to IN cord-302530-pp6bl941 377 20 Eq Eq NNP cord-302530-pp6bl941 377 21 . . . cord-302530-pp6bl941 378 1 ( ( -LRB- cord-302530-pp6bl941 378 2 19 19 CD cord-302530-pp6bl941 378 3 ) ) -RRB- cord-302530-pp6bl941 378 4 . . . cord-302530-pp6bl941 379 1 It -PRON- PRP cord-302530-pp6bl941 379 2 should should MD cord-302530-pp6bl941 379 3 be be VB cord-302530-pp6bl941 379 4 noted note VBN cord-302530-pp6bl941 379 5 that that IN cord-302530-pp6bl941 379 6 non non JJ cord-302530-pp6bl941 379 7 - - JJ cord-302530-pp6bl941 379 8 specific specific JJ cord-302530-pp6bl941 379 9 binding binding NN cord-302530-pp6bl941 379 10 to to IN cord-302530-pp6bl941 379 11 HIV HIV NNP cord-302530-pp6bl941 379 12 attachment attachment NN cord-302530-pp6bl941 379 13 factors factor NNS cord-302530-pp6bl941 379 14 would would MD cord-302530-pp6bl941 379 15 not not RB cord-302530-pp6bl941 379 16 increase increase VB cord-302530-pp6bl941 379 17 ΔS ΔS NNP cord-302530-pp6bl941 379 18 a_immob a_immob NNP cord-302530-pp6bl941 379 19 to to IN cord-302530-pp6bl941 379 20 zero zero CD cord-302530-pp6bl941 379 21 because because IN cord-302530-pp6bl941 379 22 there there EX cord-302530-pp6bl941 379 23 are be VBP cord-302530-pp6bl941 379 24 multiple multiple JJ cord-302530-pp6bl941 379 25 ways way NNS cord-302530-pp6bl941 379 26 a a DT cord-302530-pp6bl941 379 27 virus virus NN cord-302530-pp6bl941 379 28 could could MD cord-302530-pp6bl941 379 29 bind bind VB cord-302530-pp6bl941 379 30 non non JJ cord-302530-pp6bl941 379 31 - - JJ cord-302530-pp6bl941 379 32 specifically specifically RB cord-302530-pp6bl941 379 33 compared compare VBN cord-302530-pp6bl941 379 34 to to IN cord-302530-pp6bl941 379 35 the the DT cord-302530-pp6bl941 379 36 one one CD cord-302530-pp6bl941 379 37 way way NN cord-302530-pp6bl941 379 38 in in IN cord-302530-pp6bl941 379 39 which which WDT cord-302530-pp6bl941 379 40 it -PRON- PRP cord-302530-pp6bl941 379 41 binds bind VBZ cord-302530-pp6bl941 379 42 to to IN cord-302530-pp6bl941 379 43 the the DT cord-302530-pp6bl941 379 44 CD4 CD4 NNP cord-302530-pp6bl941 379 45 receptors receptor NNS cord-302530-pp6bl941 379 46 through through IN cord-302530-pp6bl941 379 47 a a DT cord-302530-pp6bl941 379 48 specific specific JJ cord-302530-pp6bl941 379 49 interaction interaction NN cord-302530-pp6bl941 379 50 between between IN cord-302530-pp6bl941 379 51 Env Env NNP cord-302530-pp6bl941 379 52 and and CC cord-302530-pp6bl941 379 53 CD4 CD4 NNP cord-302530-pp6bl941 379 54 , , , cord-302530-pp6bl941 379 55 that that DT cord-302530-pp6bl941 379 56 is be VBZ cord-302530-pp6bl941 379 57 the the DT cord-302530-pp6bl941 379 58 ΔS ΔS NNP cord-302530-pp6bl941 379 59 a_specific a_specific NNP cord-302530-pp6bl941 379 60 term term NN cord-302530-pp6bl941 379 61 is be VBZ cord-302530-pp6bl941 379 62 always always RB cord-302530-pp6bl941 379 63 negative negative JJ cord-302530-pp6bl941 380 1 i.e. i.e. FW cord-302530-pp6bl941 380 2 < < XX cord-302530-pp6bl941 380 3 0 0 CD cord-302530-pp6bl941 380 4 J J NNP cord-302530-pp6bl941 380 5 / / SYM cord-302530-pp6bl941 380 6 mol mol NNP cord-302530-pp6bl941 380 7 / / SYM cord-302530-pp6bl941 380 8 K K NNP cord-302530-pp6bl941 380 9 and and CC cord-302530-pp6bl941 380 10 ΔS ΔS NNP cord-302530-pp6bl941 380 11 a_non_specific a_non_specific NN cord-302530-pp6bl941 380 12 is be VBZ cord-302530-pp6bl941 380 13 always always RB cord-302530-pp6bl941 380 14 less less RBR cord-302530-pp6bl941 380 15 negative negative JJ cord-302530-pp6bl941 380 16 than than IN cord-302530-pp6bl941 380 17 ΔS ΔS NNP cord-302530-pp6bl941 380 18 a_immob a_immob NNP cord-302530-pp6bl941 380 19 . . . cord-302530-pp6bl941 381 1 Prior prior JJ cord-302530-pp6bl941 381 2 attachment attachment NN cord-302530-pp6bl941 381 3 through through IN cord-302530-pp6bl941 381 4 non non JJ cord-302530-pp6bl941 381 5 - - JJ cord-302530-pp6bl941 381 6 specific specific JJ cord-302530-pp6bl941 381 7 binding binding NN cord-302530-pp6bl941 381 8 would would MD cord-302530-pp6bl941 381 9 realise realise VB cord-302530-pp6bl941 381 10 the the DT cord-302530-pp6bl941 381 11 ΔS ΔS NNP cord-302530-pp6bl941 381 12 a_non_specific a_non_specific JJ cord-302530-pp6bl941 381 13 loss loss NN cord-302530-pp6bl941 381 14 before before IN cord-302530-pp6bl941 381 15 specific specific JJ cord-302530-pp6bl941 381 16 Env env NN cord-302530-pp6bl941 381 17 : : : cord-302530-pp6bl941 382 1 CD4 CD4 NNP cord-302530-pp6bl941 382 2 binding bind VBG cord-302530-pp6bl941 382 3 so so IN cord-302530-pp6bl941 382 4 that that DT cord-302530-pp6bl941 382 5 specific specific JJ cord-302530-pp6bl941 382 6 binding binding NN cord-302530-pp6bl941 382 7 involves involve VBZ cord-302530-pp6bl941 383 1 the the DT cord-302530-pp6bl941 383 2 ΔS ΔS NNP cord-302530-pp6bl941 383 3 a_specific a_specific NNP cord-302530-pp6bl941 383 4 term term NN cord-302530-pp6bl941 383 5 alone alone RB cord-302530-pp6bl941 383 6 . . . cord-302530-pp6bl941 384 1 The the DT cord-302530-pp6bl941 384 2 value value NN cord-302530-pp6bl941 384 3 of of IN cord-302530-pp6bl941 384 4 ΔS ΔS NNP cord-302530-pp6bl941 384 5 a_immob a_immob NNP cord-302530-pp6bl941 384 6 is be VBZ cord-302530-pp6bl941 384 7 estimated estimate VBN cord-302530-pp6bl941 384 8 to to TO cord-302530-pp6bl941 384 9 be be VB cord-302530-pp6bl941 384 10 −1091 −1091 NNP cord-302530-pp6bl941 384 11 J J NNP cord-302530-pp6bl941 384 12 / / SYM cord-302530-pp6bl941 384 13 mol mol NNP cord-302530-pp6bl941 384 14 / / SYM cord-302530-pp6bl941 384 15 K K NNP cord-302530-pp6bl941 384 16 ( ( -LRB- cord-302530-pp6bl941 384 17 see see VB cord-302530-pp6bl941 384 18 above above RB cord-302530-pp6bl941 384 19 ) ) -RRB- cord-302530-pp6bl941 384 20 and and CC cord-302530-pp6bl941 384 21 for for IN cord-302530-pp6bl941 384 22 the the DT cord-302530-pp6bl941 384 23 purpose purpose NN cord-302530-pp6bl941 384 24 of of IN cord-302530-pp6bl941 384 25 demonstration demonstration NN cord-302530-pp6bl941 384 26 here here RB cord-302530-pp6bl941 384 27 ΔS ΔS NNP cord-302530-pp6bl941 384 28 a_immob a_immob NNP cord-302530-pp6bl941 384 29 is be VBZ cord-302530-pp6bl941 384 30 replaced replace VBN cord-302530-pp6bl941 384 31 by by IN cord-302530-pp6bl941 384 32 ΔS ΔS NNP cord-302530-pp6bl941 384 33 a_specific a_specific NNP cord-302530-pp6bl941 384 34 in in IN cord-302530-pp6bl941 384 35 Eq Eq NNP cord-302530-pp6bl941 384 36 . . . cord-302530-pp6bl941 385 1 ( ( -LRB- cord-302530-pp6bl941 385 2 11 11 CD cord-302530-pp6bl941 385 3 ) ) -RRB- cord-302530-pp6bl941 385 4 which which WDT cord-302530-pp6bl941 385 5 is be VBZ cord-302530-pp6bl941 385 6 set set VBN cord-302530-pp6bl941 385 7 to to IN cord-302530-pp6bl941 385 8 values value NNS cord-302530-pp6bl941 385 9 of of IN cord-302530-pp6bl941 385 10 −400 −400 NNP cord-302530-pp6bl941 385 11 , , , cord-302530-pp6bl941 385 12 −337 −337 NNP cord-302530-pp6bl941 385 13 , , , cord-302530-pp6bl941 385 14 −285 −285 ADD cord-302530-pp6bl941 385 15 and and CC cord-302530-pp6bl941 385 16 −240 −240 NNP cord-302530-pp6bl941 385 17 J J NNP cord-302530-pp6bl941 385 18 / / SYM cord-302530-pp6bl941 385 19 mol mol NNP cord-302530-pp6bl941 385 20 / / SYM cord-302530-pp6bl941 385 21 K K NNP cord-302530-pp6bl941 386 1 in in IN cord-302530-pp6bl941 386 2 effect effect NN cord-302530-pp6bl941 386 3 representing represent VBG cord-302530-pp6bl941 386 4 the the DT cord-302530-pp6bl941 386 5 effect effect NN cord-302530-pp6bl941 386 6 of of IN cord-302530-pp6bl941 386 7 prior prior JJ cord-302530-pp6bl941 386 8 non non JJ cord-302530-pp6bl941 386 9 - - JJ cord-302530-pp6bl941 386 10 specific specific JJ cord-302530-pp6bl941 386 11 binding bind VBG cord-302530-pp6bl941 386 12 eliminating eliminate VBG cord-302530-pp6bl941 386 13 ΔS ΔS NNP cord-302530-pp6bl941 386 14 a_non_specific a_non_specific JJ cord-302530-pp6bl941 386 15 values value NNS cord-302530-pp6bl941 386 16 of of IN cord-302530-pp6bl941 386 17 −691 −691 DT cord-302530-pp6bl941 386 18 , , , cord-302530-pp6bl941 386 19 −754 −754 NNP cord-302530-pp6bl941 386 20 , , , cord-302530-pp6bl941 386 21 −806 −806 NNP cord-302530-pp6bl941 386 22 and and CC cord-302530-pp6bl941 386 23 −851 −851 NNP cord-302530-pp6bl941 386 24 J J NNP cord-302530-pp6bl941 386 25 / / SYM cord-302530-pp6bl941 386 26 mol mol NNP cord-302530-pp6bl941 386 27 / / SYM cord-302530-pp6bl941 386 28 K K NNP cord-302530-pp6bl941 386 29 respectively respectively RB cord-302530-pp6bl941 386 30 according accord VBG cord-302530-pp6bl941 386 31 to to IN cord-302530-pp6bl941 386 32 Eq Eq NNP cord-302530-pp6bl941 386 33 . . . cord-302530-pp6bl941 387 1 ( ( -LRB- cord-302530-pp6bl941 387 2 19 19 CD cord-302530-pp6bl941 387 3 ) ) -RRB- cord-302530-pp6bl941 387 4 . . . cord-302530-pp6bl941 388 1 2.8 2.8 CD cord-302530-pp6bl941 388 2 . . . cord-302530-pp6bl941 389 1 Case case NN cord-302530-pp6bl941 389 2 study study NN cord-302530-pp6bl941 389 3 6 6 CD cord-302530-pp6bl941 389 4 : : : cord-302530-pp6bl941 390 1 Increasing increase VBG cord-302530-pp6bl941 390 2 the the DT cord-302530-pp6bl941 390 3 number number NN cord-302530-pp6bl941 390 4 , , , cord-302530-pp6bl941 390 5 n n NN cord-302530-pp6bl941 390 6 , , , cord-302530-pp6bl941 390 7 of of IN cord-302530-pp6bl941 390 8 GP GP NNP cord-302530-pp6bl941 390 9 / / SYM cord-302530-pp6bl941 390 10 Cr cr NN cord-302530-pp6bl941 390 11 contacts contact NNS cord-302530-pp6bl941 390 12 with with IN cord-302530-pp6bl941 390 13 temperature temperature NN cord-302530-pp6bl941 390 14 to to TO cord-302530-pp6bl941 390 15 reproduce reproduce VB cord-302530-pp6bl941 390 16 the the DT cord-302530-pp6bl941 390 17 data datum NNS cord-302530-pp6bl941 390 18 of of IN cord-302530-pp6bl941 390 19 Frey Frey NNP cord-302530-pp6bl941 390 20 et et NNP cord-302530-pp6bl941 390 21 al al NNP cord-302530-pp6bl941 390 22 . . . cord-302530-pp6bl941 391 1 ( ( -LRB- cord-302530-pp6bl941 391 2 1995 1995 CD cord-302530-pp6bl941 391 3 ) ) -RRB- cord-302530-pp6bl941 391 4 _SP cord-302530-pp6bl941 392 1 Two two CD cord-302530-pp6bl941 392 2 outputs output NNS cord-302530-pp6bl941 392 3 of of IN cord-302530-pp6bl941 392 4 the the DT cord-302530-pp6bl941 392 5 model model NN cord-302530-pp6bl941 392 6 are be VBP cord-302530-pp6bl941 392 7 demonstrated demonstrate VBN cord-302530-pp6bl941 392 8 . . . cord-302530-pp6bl941 393 1 The the DT cord-302530-pp6bl941 393 2 first first JJ cord-302530-pp6bl941 393 3 output output NN cord-302530-pp6bl941 393 4 builds build VBZ cord-302530-pp6bl941 393 5 on on IN cord-302530-pp6bl941 393 6 the the DT cord-302530-pp6bl941 393 7 model model NN cord-302530-pp6bl941 393 8 in in IN cord-302530-pp6bl941 393 9 Case Case NNP cord-302530-pp6bl941 393 10 study study NN cord-302530-pp6bl941 393 11 5 5 CD cord-302530-pp6bl941 393 12 with with IN cord-302530-pp6bl941 393 13 a a DT cord-302530-pp6bl941 393 14 ΔS ΔS NNP cord-302530-pp6bl941 393 15 a_specific a_specific NNP cord-302530-pp6bl941 393 16 of of IN cord-302530-pp6bl941 393 17 −206 −206 NNP cord-302530-pp6bl941 393 18 J J NNP cord-302530-pp6bl941 393 19 / / SYM cord-302530-pp6bl941 393 20 mol mol NNP cord-302530-pp6bl941 393 21 / / SYM cord-302530-pp6bl941 393 22 K K NNP cord-302530-pp6bl941 393 23 to to TO cord-302530-pp6bl941 393 24 accommodate accommodate VB cord-302530-pp6bl941 393 25 prior prior JJ cord-302530-pp6bl941 393 26 non non JJ cord-302530-pp6bl941 393 27 - - JJ cord-302530-pp6bl941 393 28 specific specific JJ cord-302530-pp6bl941 393 29 binding binding NN cord-302530-pp6bl941 393 30 to to IN cord-302530-pp6bl941 393 31 attachment attachment NN cord-302530-pp6bl941 393 32 factors factor NNS cord-302530-pp6bl941 393 33 having have VBG cord-302530-pp6bl941 393 34 eliminated eliminate VBN cord-302530-pp6bl941 393 35 the the DT cord-302530-pp6bl941 393 36 ΔS ΔS NNP cord-302530-pp6bl941 393 37 a_non_specific a_non_specific NN cord-302530-pp6bl941 393 38 of~−900 of~−900 NNP cord-302530-pp6bl941 394 1 J J NNP cord-302530-pp6bl941 394 2 / / SYM cord-302530-pp6bl941 394 3 mol/ mol/ NNP cord-302530-pp6bl941 395 1 K. K. NNP cord-302530-pp6bl941 396 1 The the DT cord-302530-pp6bl941 396 2 model model NN cord-302530-pp6bl941 396 3 assumes assume VBZ cord-302530-pp6bl941 396 4 n n NN cord-302530-pp6bl941 396 5 = = SYM cord-302530-pp6bl941 396 6 3 3 CD cord-302530-pp6bl941 396 7 Env env NN cord-302530-pp6bl941 396 8 : : : cord-302530-pp6bl941 396 9 CD4 CD4 NNP cord-302530-pp6bl941 396 10 interactions interaction NNS cord-302530-pp6bl941 396 11 where where WRB cord-302530-pp6bl941 396 12 n n CC cord-302530-pp6bl941 396 13 in in IN cord-302530-pp6bl941 396 14 Eq Eq NNP cord-302530-pp6bl941 396 15 . . . cord-302530-pp6bl941 397 1 ( ( -LRB- cord-302530-pp6bl941 397 2 11 11 CD cord-302530-pp6bl941 397 3 ) ) -RRB- cord-302530-pp6bl941 397 4 is be VBZ cord-302530-pp6bl941 397 5 increased increase VBN cord-302530-pp6bl941 397 6 from from IN cord-302530-pp6bl941 397 7 n n NN cord-302530-pp6bl941 397 8 = = SYM cord-302530-pp6bl941 397 9 1 1 CD cord-302530-pp6bl941 397 10 to to IN cord-302530-pp6bl941 397 11 n n NN cord-302530-pp6bl941 397 12 = = SYM cord-302530-pp6bl941 397 13 3 3 CD cord-302530-pp6bl941 397 14 with with IN cord-302530-pp6bl941 397 15 temperature temperature NN cord-302530-pp6bl941 397 16 between between IN cord-302530-pp6bl941 397 17 25 25 CD cord-302530-pp6bl941 397 18 ° ° NN cord-302530-pp6bl941 397 19 C c NN cord-302530-pp6bl941 397 20 and and CC cord-302530-pp6bl941 397 21 27 27 CD cord-302530-pp6bl941 397 22 ° ° NN cord-302530-pp6bl941 397 23 C c NN cord-302530-pp6bl941 397 24 ( ( -LRB- cord-302530-pp6bl941 397 25 Fig Fig NNP cord-302530-pp6bl941 397 26 . . . cord-302530-pp6bl941 397 27 6a 6a LS cord-302530-pp6bl941 397 28 ) ) -RRB- cord-302530-pp6bl941 397 29 to to TO cord-302530-pp6bl941 397 30 represent represent VB cord-302530-pp6bl941 397 31 the the DT cord-302530-pp6bl941 397 32 increase increase NN cord-302530-pp6bl941 397 33 in in IN cord-302530-pp6bl941 397 34 contacts contact NNS cord-302530-pp6bl941 397 35 reported report VBN cord-302530-pp6bl941 397 36 by by IN cord-302530-pp6bl941 397 37 Frey Frey NNP cord-302530-pp6bl941 397 38 et et NNP cord-302530-pp6bl941 397 39 al al NNP cord-302530-pp6bl941 397 40 . . . cord-302530-pp6bl941 398 1 ( ( -LRB- cord-302530-pp6bl941 398 2 1995 1995 CD cord-302530-pp6bl941 398 3 ) ) -RRB- cord-302530-pp6bl941 398 4 . . . cord-302530-pp6bl941 399 1 The the DT cord-302530-pp6bl941 399 2 second second JJ cord-302530-pp6bl941 399 3 output output NN cord-302530-pp6bl941 399 4 attempts attempt NNS cord-302530-pp6bl941 399 5 to to TO cord-302530-pp6bl941 399 6 include include VB cord-302530-pp6bl941 399 7 non non JJ cord-302530-pp6bl941 399 8 - - JJ cord-302530-pp6bl941 399 9 specific specific JJ cord-302530-pp6bl941 399 10 binding binding NN cord-302530-pp6bl941 399 11 and and CC cord-302530-pp6bl941 399 12 also also RB cord-302530-pp6bl941 399 13 CCR5 ccr5 JJ cord-302530-pp6bl941 399 14 co co NN cord-302530-pp6bl941 399 15 - - NN cord-302530-pp6bl941 399 16 receptor receptor NN cord-302530-pp6bl941 399 17 binding binding NN cord-302530-pp6bl941 399 18 and and CC cord-302530-pp6bl941 399 19 a a DT cord-302530-pp6bl941 399 20 ΔS ΔS NNP cord-302530-pp6bl941 399 21 a_immob a_immob NN cord-302530-pp6bl941 399 22 of of IN cord-302530-pp6bl941 399 23 −1110 −1110 NNP cord-302530-pp6bl941 399 24 J J NNP cord-302530-pp6bl941 399 25 / / SYM cord-302530-pp6bl941 399 26 mol mol NNP cord-302530-pp6bl941 399 27 / / SYM cord-302530-pp6bl941 399 28 K K NNP cord-302530-pp6bl941 399 29 is be VBZ cord-302530-pp6bl941 399 30 used use VBN cord-302530-pp6bl941 399 31 to to TO cord-302530-pp6bl941 399 32 represent represent VB cord-302530-pp6bl941 399 33 the the DT cord-302530-pp6bl941 399 34 free free JJ cord-302530-pp6bl941 399 35 virus virus NN cord-302530-pp6bl941 399 36 binding bind VBG cord-302530-pp6bl941 399 37 ( ( -LRB- cord-302530-pp6bl941 399 38 i.e. i.e. FW cord-302530-pp6bl941 399 39 prior prior RB cord-302530-pp6bl941 399 40 to to IN cord-302530-pp6bl941 399 41 non non JJ cord-302530-pp6bl941 399 42 - - JJ cord-302530-pp6bl941 399 43 specific specific JJ cord-302530-pp6bl941 399 44 binding binding NN cord-302530-pp6bl941 399 45 ) ) -RRB- cord-302530-pp6bl941 399 46 . . . cord-302530-pp6bl941 400 1 Kuhmann Kuhmann NNP cord-302530-pp6bl941 400 2 et et NNP cord-302530-pp6bl941 400 3 al al NNP cord-302530-pp6bl941 400 4 . . . cord-302530-pp6bl941 401 1 ( ( -LRB- cord-302530-pp6bl941 401 2 2000 2000 CD cord-302530-pp6bl941 401 3 ) ) -RRB- cord-302530-pp6bl941 401 4 demonstrated demonstrate VBD cord-302530-pp6bl941 401 5 that that IN cord-302530-pp6bl941 401 6 approximately approximately RB cord-302530-pp6bl941 401 7 four four CD cord-302530-pp6bl941 401 8 to to TO cord-302530-pp6bl941 401 9 six six CD cord-302530-pp6bl941 401 10 CCR5 CCR5 NNP cord-302530-pp6bl941 401 11 molecules molecule NNS cord-302530-pp6bl941 401 12 assemble assemble VBP cord-302530-pp6bl941 401 13 around around IN cord-302530-pp6bl941 401 14 the the DT cord-302530-pp6bl941 401 15 HIV HIV NNP cord-302530-pp6bl941 401 16 virion virion NN cord-302530-pp6bl941 401 17 to to TO cord-302530-pp6bl941 401 18 form form VB cord-302530-pp6bl941 401 19 a a DT cord-302530-pp6bl941 401 20 complex complex JJ cord-302530-pp6bl941 401 21 needed need VBN cord-302530-pp6bl941 401 22 for for IN cord-302530-pp6bl941 401 23 infection infection NN cord-302530-pp6bl941 401 24 . . . cord-302530-pp6bl941 402 1 The the DT cord-302530-pp6bl941 402 2 model model NN cord-302530-pp6bl941 402 3 here here RB cord-302530-pp6bl941 402 4 assumes assume VBZ cord-302530-pp6bl941 402 5 n n NN cord-302530-pp6bl941 402 6 = = SYM cord-302530-pp6bl941 402 7 2 2 CD cord-302530-pp6bl941 402 8 non non JJ cord-302530-pp6bl941 402 9 - - JJ cord-302530-pp6bl941 402 10 specific specific JJ cord-302530-pp6bl941 402 11 Env Env NNP cord-302530-pp6bl941 402 12 interactions interaction NNS cord-302530-pp6bl941 402 13 with with IN cord-302530-pp6bl941 402 14 attachment attachment NN cord-302530-pp6bl941 402 15 factors factor NNS cord-302530-pp6bl941 402 16 followed follow VBN cord-302530-pp6bl941 402 17 by by IN cord-302530-pp6bl941 402 18 n n NN cord-302530-pp6bl941 402 19 = = SYM cord-302530-pp6bl941 402 20 4 4 CD cord-302530-pp6bl941 402 21 Env env NN cord-302530-pp6bl941 402 22 : : : cord-302530-pp6bl941 403 1 CCR5 ccr5 JJ cord-302530-pp6bl941 403 2 interactions interaction NNS cord-302530-pp6bl941 403 3 according accord VBG cord-302530-pp6bl941 403 4 to to IN cord-302530-pp6bl941 403 5 Kuhmann Kuhmann NNP cord-302530-pp6bl941 403 6 et et NNP cord-302530-pp6bl941 403 7 al al NNP cord-302530-pp6bl941 403 8 . . . cord-302530-pp6bl941 404 1 ( ( -LRB- cord-302530-pp6bl941 404 2 2000 2000 CD cord-302530-pp6bl941 404 3 ) ) -RRB- cord-302530-pp6bl941 405 1 and and CC cord-302530-pp6bl941 405 2 finally finally RB cord-302530-pp6bl941 405 3 n n NN cord-302530-pp6bl941 405 4 = = SYM cord-302530-pp6bl941 405 5 3 3 CD cord-302530-pp6bl941 405 6 Env env NN cord-302530-pp6bl941 405 7 : : : cord-302530-pp6bl941 406 1 CD4 CD4 NNP cord-302530-pp6bl941 406 2 interactions interaction NNS cord-302530-pp6bl941 406 3 based base VBN cord-302530-pp6bl941 406 4 on on IN cord-302530-pp6bl941 406 5 Brandenberg Brandenberg NNP cord-302530-pp6bl941 406 6 et et FW cord-302530-pp6bl941 406 7 al al NNP cord-302530-pp6bl941 406 8 . . . cord-302530-pp6bl941 407 1 ( ( -LRB- cord-302530-pp6bl941 407 2 2015 2015 CD cord-302530-pp6bl941 407 3 ) ) -RRB- cord-302530-pp6bl941 407 4 to to TO cord-302530-pp6bl941 407 5 form form VB cord-302530-pp6bl941 407 6 a a DT cord-302530-pp6bl941 407 7 complex complex NN cord-302530-pp6bl941 407 8 for for IN cord-302530-pp6bl941 407 9 binding bind VBG cord-302530-pp6bl941 407 10 with with IN cord-302530-pp6bl941 407 11 n n NN cord-302530-pp6bl941 407 12 = = SYM cord-302530-pp6bl941 407 13 9 9 CD cord-302530-pp6bl941 407 14 contacts contact NNS cord-302530-pp6bl941 407 15 in in IN cord-302530-pp6bl941 407 16 total total NN cord-302530-pp6bl941 407 17 which which WDT cord-302530-pp6bl941 407 18 increase increase NN cord-302530-pp6bl941 407 19 from from IN cord-302530-pp6bl941 407 20 1 1 CD cord-302530-pp6bl941 407 21 to to IN cord-302530-pp6bl941 407 22 9 9 CD cord-302530-pp6bl941 407 23 with with IN cord-302530-pp6bl941 407 24 temperature temperature NN cord-302530-pp6bl941 407 25 as as IN cord-302530-pp6bl941 407 26 shown show VBN cord-302530-pp6bl941 407 27 in in IN cord-302530-pp6bl941 407 28 Fig Fig NNP cord-302530-pp6bl941 407 29 . . . cord-302530-pp6bl941 408 1 6b 6b CD cord-302530-pp6bl941 408 2 . . . cord-302530-pp6bl941 409 1 Doranz Doranz NNP cord-302530-pp6bl941 409 2 et et NNP cord-302530-pp6bl941 409 3 al al NNP cord-302530-pp6bl941 409 4 . . . cord-302530-pp6bl941 410 1 ( ( -LRB- cord-302530-pp6bl941 410 2 1999 1999 CD cord-302530-pp6bl941 410 3 ) ) -RRB- cord-302530-pp6bl941 410 4 estimated estimate VBD cord-302530-pp6bl941 410 5 the the DT cord-302530-pp6bl941 410 6 K K NNP cord-302530-pp6bl941 410 7 d_receptor_T d_receptor_T NNP cord-302530-pp6bl941 410 8 of of IN cord-302530-pp6bl941 410 9 interaction interaction NN cord-302530-pp6bl941 410 10 between between IN cord-302530-pp6bl941 410 11 CCR5 CCR5 NNP cord-302530-pp6bl941 410 12 and and CC cord-302530-pp6bl941 410 13 HIV HIV NNP cord-302530-pp6bl941 410 14 gp120 gp120 NNP cord-302530-pp6bl941 410 15 to to TO cord-302530-pp6bl941 410 16 be be VB cord-302530-pp6bl941 410 17 4 4 CD cord-302530-pp6bl941 410 18 × × CD cord-302530-pp6bl941 410 19 10 10 CD cord-302530-pp6bl941 410 20 −9 −9 NNP cord-302530-pp6bl941 410 21 M. m. NN cord-302530-pp6bl941 411 1 This this DT cord-302530-pp6bl941 411 2 is be VBZ cord-302530-pp6bl941 411 3 remarkably remarkably RB cord-302530-pp6bl941 411 4 similar similar JJ cord-302530-pp6bl941 411 5 to to IN cord-302530-pp6bl941 411 6 the the DT cord-302530-pp6bl941 411 7 K K NNP cord-302530-pp6bl941 411 8 d_receptor_T d_receptor_T NNP cord-302530-pp6bl941 411 9 for for IN cord-302530-pp6bl941 411 10 the the DT cord-302530-pp6bl941 411 11 interaction interaction NN cord-302530-pp6bl941 411 12 between between IN cord-302530-pp6bl941 411 13 CD4 CD4 NNP cord-302530-pp6bl941 411 14 and and CC cord-302530-pp6bl941 411 15 HIV HIV NNP cord-302530-pp6bl941 411 16 Env Env NNP cord-302530-pp6bl941 411 17 of of IN cord-302530-pp6bl941 411 18 4.75 4.75 CD cord-302530-pp6bl941 411 19 × × NN cord-302530-pp6bl941 411 20 10 10 CD cord-302530-pp6bl941 411 21 −9 −9 NNP cord-302530-pp6bl941 411 22 M M NNP cord-302530-pp6bl941 411 23 at at IN cord-302530-pp6bl941 411 24 37 37 CD cord-302530-pp6bl941 411 25 ° ° NN cord-302530-pp6bl941 411 26 C c NN cord-302530-pp6bl941 411 27 ( ( -LRB- cord-302530-pp6bl941 411 28 Table Table NNP cord-302530-pp6bl941 411 29 4 4 CD cord-302530-pp6bl941 411 30 ) ) -RRB- cord-302530-pp6bl941 411 31 and and CC cord-302530-pp6bl941 411 32 the the DT cord-302530-pp6bl941 411 33 same same JJ cord-302530-pp6bl941 411 34 values value NNS cord-302530-pp6bl941 411 35 for for IN cord-302530-pp6bl941 411 36 ΔH ΔH NNP cord-302530-pp6bl941 411 37 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 411 38 and and CC cord-302530-pp6bl941 411 39 ΔS ΔS NNP cord-302530-pp6bl941 411 40 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 411 41 not not RB cord-302530-pp6bl941 411 42 only only RB cord-302530-pp6bl941 411 43 for for IN cord-302530-pp6bl941 411 44 the the DT cord-302530-pp6bl941 411 45 four four CD cord-302530-pp6bl941 411 46 HIV HIV NNP cord-302530-pp6bl941 411 47 Env Env NNP cord-302530-pp6bl941 411 48 : : : cord-302530-pp6bl941 411 49 CCR5 ccr5 JJ cord-302530-pp6bl941 411 50 interactions interaction NNS cord-302530-pp6bl941 411 51 but but CC cord-302530-pp6bl941 411 52 also also RB cord-302530-pp6bl941 412 1 for for IN cord-302530-pp6bl941 412 2 the the DT cord-302530-pp6bl941 412 3 two two CD cord-302530-pp6bl941 412 4 nonspecific nonspecific JJ cord-302530-pp6bl941 412 5 interactions interaction NNS cord-302530-pp6bl941 412 6 are be VBP cord-302530-pp6bl941 412 7 therefore therefore RB cord-302530-pp6bl941 412 8 used use VBN cord-302530-pp6bl941 412 9 as as IN cord-302530-pp6bl941 412 10 for for IN cord-302530-pp6bl941 412 11 the the DT cord-302530-pp6bl941 412 12 three three CD cord-302530-pp6bl941 412 13 HIV HIV NNP cord-302530-pp6bl941 412 14 Env Env NNP cord-302530-pp6bl941 412 15 : : : cord-302530-pp6bl941 413 1 CD4 CD4 NNP cord-302530-pp6bl941 413 2 interactions interaction NNS cord-302530-pp6bl941 413 3 in in IN cord-302530-pp6bl941 413 4 Table Table NNP cord-302530-pp6bl941 413 5 4 4 CD cord-302530-pp6bl941 413 6 with with IN cord-302530-pp6bl941 413 7 the the DT cord-302530-pp6bl941 413 8 reference reference NN cord-302530-pp6bl941 413 9 temperature temperature NN cord-302530-pp6bl941 413 10 , , , cord-302530-pp6bl941 413 11 T t NN cord-302530-pp6bl941 413 12 0 0 CD cord-302530-pp6bl941 413 13 at at IN cord-302530-pp6bl941 413 14 37 37 CD cord-302530-pp6bl941 413 15 ° ° NN cord-302530-pp6bl941 413 16 C c NN cord-302530-pp6bl941 413 17 . . . cord-302530-pp6bl941 414 1 Published publish VBN cord-302530-pp6bl941 414 2 values value NNS cord-302530-pp6bl941 414 3 of of IN cord-302530-pp6bl941 414 4 ΔC ΔC NNP cord-302530-pp6bl941 414 5 p p NNP cord-302530-pp6bl941 414 6 for for IN cord-302530-pp6bl941 414 7 protein protein NN cord-302530-pp6bl941 414 8 / / SYM cord-302530-pp6bl941 414 9 protein protein NN cord-302530-pp6bl941 414 10 binding binding NN cord-302530-pp6bl941 414 11 and and CC cord-302530-pp6bl941 414 12 for for IN cord-302530-pp6bl941 414 13 AIV AIV NNP cord-302530-pp6bl941 414 14 HA HA NNP cord-302530-pp6bl941 414 15 binding bind VBG cord-302530-pp6bl941 414 16 to to IN cord-302530-pp6bl941 414 17 SA SA NNP cord-302530-pp6bl941 414 18 glycans glycan NNS cord-302530-pp6bl941 414 19 vary vary VBP cord-302530-pp6bl941 414 20 in in IN cord-302530-pp6bl941 414 21 magnitude magnitude NN cord-302530-pp6bl941 414 22 ( ( -LRB- cord-302530-pp6bl941 414 23 Table table NN cord-302530-pp6bl941 414 24 3 3 CD cord-302530-pp6bl941 414 25 ) ) -RRB- cord-302530-pp6bl941 414 26 . . . cord-302530-pp6bl941 415 1 For for IN cord-302530-pp6bl941 415 2 the the DT cord-302530-pp6bl941 415 3 binding binding NN cord-302530-pp6bl941 415 4 of of IN cord-302530-pp6bl941 415 5 HIV HIV NNP cord-302530-pp6bl941 415 6 gp120 gp120 NNP cord-302530-pp6bl941 415 7 to to IN cord-302530-pp6bl941 415 8 CD4 CD4 NNP cord-302530-pp6bl941 415 9 which which WDT cord-302530-pp6bl941 415 10 is be VBZ cord-302530-pp6bl941 415 11 a a DT cord-302530-pp6bl941 415 12 protein protein NN cord-302530-pp6bl941 415 13 - - HYPH cord-302530-pp6bl941 415 14 protein protein NN cord-302530-pp6bl941 415 15 interaction interaction NN cord-302530-pp6bl941 415 16 , , , cord-302530-pp6bl941 415 17 the the DT cord-302530-pp6bl941 415 18 magnitude magnitude NN cord-302530-pp6bl941 415 19 of of IN cord-302530-pp6bl941 415 20 ΔH ΔH NNP cord-302530-pp6bl941 415 21 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 415 22 becomes become VBZ cord-302530-pp6bl941 415 23 more more RBR cord-302530-pp6bl941 415 24 negative negative JJ cord-302530-pp6bl941 415 25 as as IN cord-302530-pp6bl941 415 26 the the DT cord-302530-pp6bl941 415 27 temperature temperature NN cord-302530-pp6bl941 415 28 increases increase NNS cord-302530-pp6bl941 416 1 i.e. i.e. FW cord-302530-pp6bl941 416 2 ΔC ΔC NNP cord-302530-pp6bl941 416 3 p p NNP cord-302530-pp6bl941 416 4 is be VBZ cord-302530-pp6bl941 416 5 negative negative JJ cord-302530-pp6bl941 417 1 ( ( -LRB- cord-302530-pp6bl941 417 2 Fig Fig NNP cord-302530-pp6bl941 417 3 . . NNP cord-302530-pp6bl941 417 4 1 1 CD cord-302530-pp6bl941 417 5 ) ) -RRB- cord-302530-pp6bl941 417 6 . . . cord-302530-pp6bl941 418 1 Similarly similarly RB cord-302530-pp6bl941 418 2 , , , cord-302530-pp6bl941 418 3 negative negative JJ cord-302530-pp6bl941 418 4 values value NNS cord-302530-pp6bl941 418 5 of of IN cord-302530-pp6bl941 418 6 ΔC ΔC NNP cord-302530-pp6bl941 418 7 p p NNP cord-302530-pp6bl941 418 8 were be VBD cord-302530-pp6bl941 418 9 reported report VBN cord-302530-pp6bl941 418 10 for for IN cord-302530-pp6bl941 418 11 other other JJ cord-302530-pp6bl941 418 12 protein protein NN cord-302530-pp6bl941 418 13 - - HYPH cord-302530-pp6bl941 418 14 protein protein NN cord-302530-pp6bl941 418 15 systems system NNS cord-302530-pp6bl941 418 16 , , , cord-302530-pp6bl941 418 17 namely namely RB cord-302530-pp6bl941 418 18 the the DT cord-302530-pp6bl941 418 19 binding binding NN cord-302530-pp6bl941 418 20 of of IN cord-302530-pp6bl941 418 21 E3 E3 NNP cord-302530-pp6bl941 418 22 and and CC cord-302530-pp6bl941 418 23 E1 e1 NN cord-302530-pp6bl941 418 24 proteins protein NNS cord-302530-pp6bl941 418 25 , , , cord-302530-pp6bl941 418 26 respectively respectively RB cord-302530-pp6bl941 418 27 , , , cord-302530-pp6bl941 418 28 in in IN cord-302530-pp6bl941 418 29 the the DT cord-302530-pp6bl941 418 30 assembly assembly NN cord-302530-pp6bl941 418 31 of of IN cord-302530-pp6bl941 418 32 the the DT cord-302530-pp6bl941 418 33 enzyme enzyme NN cord-302530-pp6bl941 418 34 pyruvate pyruvate NN cord-302530-pp6bl941 418 35 dehydrogenase dehydrogenase NN cord-302530-pp6bl941 418 36 ( ( -LRB- cord-302530-pp6bl941 418 37 Jung Jung NNP cord-302530-pp6bl941 418 38 et et NNP cord-302530-pp6bl941 418 39 al al NNP cord-302530-pp6bl941 418 40 . . NNP cord-302530-pp6bl941 418 41 , , , cord-302530-pp6bl941 418 42 2002 2002 CD cord-302530-pp6bl941 418 43 ) ) -RRB- cord-302530-pp6bl941 418 44 , , , cord-302530-pp6bl941 418 45 although although IN cord-302530-pp6bl941 418 46 with with IN cord-302530-pp6bl941 418 47 ΔC ΔC NNP cord-302530-pp6bl941 418 48 p p NN cord-302530-pp6bl941 418 49 values value NNS cord-302530-pp6bl941 418 50 less less RBR cord-302530-pp6bl941 418 51 negative negative JJ cord-302530-pp6bl941 418 52 than than IN cord-302530-pp6bl941 418 53 that that DT cord-302530-pp6bl941 418 54 for for IN cord-302530-pp6bl941 418 55 HIV HIV NNP cord-302530-pp6bl941 419 1 gp120 gp120 NNP cord-302530-pp6bl941 419 2 : : : cord-302530-pp6bl941 420 1 CD4 CD4 NNP cord-302530-pp6bl941 420 2 ( ( -LRB- cord-302530-pp6bl941 420 3 Table Table NNP cord-302530-pp6bl941 420 4 3 3 CD cord-302530-pp6bl941 420 5 ) ) -RRB- cord-302530-pp6bl941 420 6 . . . cord-302530-pp6bl941 421 1 In in IN cord-302530-pp6bl941 421 2 contrast contrast NN cord-302530-pp6bl941 421 3 for for IN cord-302530-pp6bl941 421 4 AIV AIV NNP cord-302530-pp6bl941 421 5 HA HA NNP cord-302530-pp6bl941 421 6 binding bind VBG cord-302530-pp6bl941 421 7 to to IN cord-302530-pp6bl941 421 8 the the DT cord-302530-pp6bl941 421 9 SA SA NNP cord-302530-pp6bl941 421 10 glycan glycan NN cord-302530-pp6bl941 421 11 the the DT cord-302530-pp6bl941 421 12 magnitude magnitude NN cord-302530-pp6bl941 421 13 of of IN cord-302530-pp6bl941 421 14 ΔC ΔC NNP cord-302530-pp6bl941 421 15 p p NNP cord-302530-pp6bl941 421 16 is be VBZ cord-302530-pp6bl941 421 17 not not RB cord-302530-pp6bl941 421 18 significantly significantly RB cord-302530-pp6bl941 421 19 different different JJ cord-302530-pp6bl941 421 20 from from IN cord-302530-pp6bl941 421 21 zero zero CD cord-302530-pp6bl941 421 22 with with IN cord-302530-pp6bl941 421 23 ΔH ΔH NNP cord-302530-pp6bl941 421 24 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 421 25 constant constant NN cord-302530-pp6bl941 421 26 over over IN cord-302530-pp6bl941 421 27 the the DT cord-302530-pp6bl941 421 28 temperature temperature NN cord-302530-pp6bl941 421 29 range range NN cord-302530-pp6bl941 421 30 15 15 CD cord-302530-pp6bl941 421 31 ° ° NN cord-302530-pp6bl941 421 32 C c NN cord-302530-pp6bl941 421 33 to to IN cord-302530-pp6bl941 421 34 25 25 CD cord-302530-pp6bl941 421 35 ° ° NN cord-302530-pp6bl941 421 36 C c NN cord-302530-pp6bl941 421 37 at at IN cord-302530-pp6bl941 421 38 least least JJS cord-302530-pp6bl941 421 39 for for IN cord-302530-pp6bl941 421 40 binding bind VBG cord-302530-pp6bl941 421 41 of of IN cord-302530-pp6bl941 421 42 both both DT cord-302530-pp6bl941 421 43 α2 α2 NNP cord-302530-pp6bl941 421 44 - - HYPH cord-302530-pp6bl941 421 45 3 3 CD cord-302530-pp6bl941 421 46 and and CC cord-302530-pp6bl941 421 47 α2 α2 NNP cord-302530-pp6bl941 421 48 - - HYPH cord-302530-pp6bl941 421 49 6 6 CD cord-302530-pp6bl941 421 50 sialyllactose sialyllactose NN cord-302530-pp6bl941 421 51 ( ( -LRB- cord-302530-pp6bl941 421 52 Fig Fig NNP cord-302530-pp6bl941 421 53 . . . cord-302530-pp6bl941 421 54 1 1 CD cord-302530-pp6bl941 421 55 ) ) -RRB- cord-302530-pp6bl941 421 56 . . . cord-302530-pp6bl941 422 1 Values value NNS cord-302530-pp6bl941 422 2 of of IN cord-302530-pp6bl941 422 3 K K NNP cord-302530-pp6bl941 422 4 a_virus_T a_virus_T NNP cord-302530-pp6bl941 422 5 predicted predict VBD cord-302530-pp6bl941 422 6 over over IN cord-302530-pp6bl941 422 7 the the DT cord-302530-pp6bl941 422 8 temperature temperature NN cord-302530-pp6bl941 422 9 range range NN cord-302530-pp6bl941 422 10 of of IN cord-302530-pp6bl941 422 11 10 10 CD cord-302530-pp6bl941 422 12 ° ° NN cord-302530-pp6bl941 422 13 C c NN cord-302530-pp6bl941 422 14 to to IN cord-302530-pp6bl941 422 15 37 37 CD cord-302530-pp6bl941 422 16 ° ° NN cord-302530-pp6bl941 422 17 C c NN cord-302530-pp6bl941 422 18 using use VBG cord-302530-pp6bl941 422 19 different different JJ cord-302530-pp6bl941 422 20 values value NNS cord-302530-pp6bl941 422 21 of of IN cord-302530-pp6bl941 422 22 ΔC ΔC NNP cord-302530-pp6bl941 422 23 p p NN cord-302530-pp6bl941 422 24 intercept intercept VB cord-302530-pp6bl941 422 25 at at IN cord-302530-pp6bl941 422 26 the the DT cord-302530-pp6bl941 422 27 reference reference NN cord-302530-pp6bl941 422 28 temperature temperature NN cord-302530-pp6bl941 422 29 ( ( -LRB- cord-302530-pp6bl941 422 30 T T NNP cord-302530-pp6bl941 422 31 0 0 CD cord-302530-pp6bl941 422 32 ) ) -RRB- cord-302530-pp6bl941 422 33 of of IN cord-302530-pp6bl941 422 34 37 37 CD cord-302530-pp6bl941 422 35 ° ° NN cord-302530-pp6bl941 422 36 C c NN cord-302530-pp6bl941 422 37 ( ( -LRB- cord-302530-pp6bl941 422 38 Fig Fig NNP cord-302530-pp6bl941 422 39 . . . cord-302530-pp6bl941 422 40 2a 2a CD cord-302530-pp6bl941 422 41 ) ) -RRB- cord-302530-pp6bl941 422 42 with with IN cord-302530-pp6bl941 422 43 K K NNP cord-302530-pp6bl941 422 44 a_virus_T a_virus_T NNP cord-302530-pp6bl941 422 45 = = NFP cord-302530-pp6bl941 423 1 10 10 CD cord-302530-pp6bl941 423 2 12 12 CD cord-302530-pp6bl941 423 3 M M NNP cord-302530-pp6bl941 423 4 − − NNP cord-302530-pp6bl941 423 5 1 1 CD cord-302530-pp6bl941 424 1 as as IN cord-302530-pp6bl941 424 2 expected expect VBN cord-302530-pp6bl941 424 3 for for IN cord-302530-pp6bl941 424 4 n n NN cord-302530-pp6bl941 424 5 = = SYM cord-302530-pp6bl941 424 6 4 4 CD cord-302530-pp6bl941 424 7 GP GP NNP cord-302530-pp6bl941 424 8 / / SYM cord-302530-pp6bl941 424 9 Cr cr NN cord-302530-pp6bl941 424 10 interactions interaction NNS cord-302530-pp6bl941 424 11 each each DT cord-302530-pp6bl941 424 12 of of IN cord-302530-pp6bl941 424 13 K K NNP cord-302530-pp6bl941 424 14 d_receptor_T0 d_receptor_t0 NN cord-302530-pp6bl941 424 15 of of IN cord-302530-pp6bl941 424 16 10 10 CD cord-302530-pp6bl941 424 17 −3 −3 NN cord-302530-pp6bl941 424 18 M M NNP cord-302530-pp6bl941 424 19 ( ( -LRB- cord-302530-pp6bl941 424 20 Eq Eq NNP cord-302530-pp6bl941 424 21 . . . cord-302530-pp6bl941 425 1 ( ( -LRB- cord-302530-pp6bl941 425 2 17 17 CD cord-302530-pp6bl941 425 3 ) ) -RRB- cord-302530-pp6bl941 425 4 ) ) -RRB- cord-302530-pp6bl941 425 5 . . . cord-302530-pp6bl941 426 1 With with IN cord-302530-pp6bl941 426 2 ΔC ΔC NNP cord-302530-pp6bl941 426 3 p p NN cord-302530-pp6bl941 426 4 = = SYM cord-302530-pp6bl941 426 5 0 0 CD cord-302530-pp6bl941 426 6 kJ kJ NNP cord-302530-pp6bl941 426 7 / / SYM cord-302530-pp6bl941 426 8 mol mol NNP cord-302530-pp6bl941 426 9 / / SYM cord-302530-pp6bl941 426 10 K K NNP cord-302530-pp6bl941 426 11 as as IN cord-302530-pp6bl941 426 12 for for IN cord-302530-pp6bl941 426 13 AIV AIV NNP cord-302530-pp6bl941 426 14 HA HA NNP cord-302530-pp6bl941 426 15 / / SYM cord-302530-pp6bl941 426 16 SA SA NNP cord-302530-pp6bl941 426 17 , , , cord-302530-pp6bl941 426 18 K K NNP cord-302530-pp6bl941 426 19 a_virus_T a_virus_T NNP cord-302530-pp6bl941 426 20 increases increase VBZ cord-302530-pp6bl941 426 21 with with IN cord-302530-pp6bl941 426 22 decreasing decrease VBG cord-302530-pp6bl941 426 23 temperature temperature NN cord-302530-pp6bl941 426 24 according accord VBG cord-302530-pp6bl941 426 25 to to IN cord-302530-pp6bl941 426 26 the the DT cord-302530-pp6bl941 426 27 Van't Van't NNPS cord-302530-pp6bl941 426 28 Hoff Hoff NNP cord-302530-pp6bl941 426 29 Isochore Isochore NNP cord-302530-pp6bl941 426 30 . . . cord-302530-pp6bl941 427 1 In in IN cord-302530-pp6bl941 427 2 contrast contrast NN cord-302530-pp6bl941 427 3 with with IN cord-302530-pp6bl941 427 4 ΔC ΔC NNP cord-302530-pp6bl941 427 5 p p NN cord-302530-pp6bl941 427 6 = = NN cord-302530-pp6bl941 427 7 −5.02 −5.02 NNP cord-302530-pp6bl941 427 8 kJ kJ NNP cord-302530-pp6bl941 427 9 / / SYM cord-302530-pp6bl941 427 10 mol mol NNP cord-302530-pp6bl941 427 11 / / SYM cord-302530-pp6bl941 427 12 K K NNP cord-302530-pp6bl941 427 13 as as IN cord-302530-pp6bl941 427 14 for for IN cord-302530-pp6bl941 427 15 HIV HIV NNP cord-302530-pp6bl941 427 16 gp120 gp120 NNP cord-302530-pp6bl941 427 17 : : : cord-302530-pp6bl941 427 18 CD4 CD4 NNP cord-302530-pp6bl941 427 19 , , , cord-302530-pp6bl941 427 20 K K NNP cord-302530-pp6bl941 427 21 a_virus_T a_virus_T NNP cord-302530-pp6bl941 427 22 peaks peak NNS cord-302530-pp6bl941 427 23 at at IN cord-302530-pp6bl941 427 24 26 26 CD cord-302530-pp6bl941 427 25 ° ° NN cord-302530-pp6bl941 427 26 C c NN cord-302530-pp6bl941 427 27 and and CC cord-302530-pp6bl941 427 28 decreases decrease VBZ cord-302530-pp6bl941 427 29 rapidly rapidly RB cord-302530-pp6bl941 427 30 at at IN cord-302530-pp6bl941 427 31 lower low JJR cord-302530-pp6bl941 427 32 temperatures temperature NNS cord-302530-pp6bl941 427 33 . . . cord-302530-pp6bl941 428 1 For for IN cord-302530-pp6bl941 428 2 the the DT cord-302530-pp6bl941 428 3 simulated simulated JJ cord-302530-pp6bl941 428 4 DENV DENV NNP cord-302530-pp6bl941 428 5 / / SYM cord-302530-pp6bl941 428 6 Ae Ae NNP cord-302530-pp6bl941 428 7 . . . cord-302530-pp6bl941 428 8 albopictus albopictus NNP cord-302530-pp6bl941 428 9 model model NN cord-302530-pp6bl941 428 10 used use VBN cord-302530-pp6bl941 428 11 here here RB cord-302530-pp6bl941 428 12 , , , cord-302530-pp6bl941 428 13 small small JJ cord-302530-pp6bl941 428 14 negative negative JJ cord-302530-pp6bl941 428 15 values value NNS cord-302530-pp6bl941 428 16 of of IN cord-302530-pp6bl941 428 17 ΔC ΔC NNP cord-302530-pp6bl941 428 18 p p NN cord-302530-pp6bl941 428 19 ( ( -LRB- cord-302530-pp6bl941 428 20 −2.0 −2.0 NNP cord-302530-pp6bl941 428 21 kJ kJ NNP cord-302530-pp6bl941 428 22 / / SYM cord-302530-pp6bl941 428 23 mol mol NNP cord-302530-pp6bl941 428 24 / / SYM cord-302530-pp6bl941 428 25 K K NNP cord-302530-pp6bl941 428 26 to to IN cord-302530-pp6bl941 428 27 0 0 CD cord-302530-pp6bl941 428 28 kJ kJ NNP cord-302530-pp6bl941 428 29 / / SYM cord-302530-pp6bl941 428 30 mol mol NNP cord-302530-pp6bl941 428 31 / / SYM cord-302530-pp6bl941 428 32 K K NNP cord-302530-pp6bl941 428 33 ) ) -RRB- cord-302530-pp6bl941 428 34 have have VBP cord-302530-pp6bl941 428 35 little little JJ cord-302530-pp6bl941 428 36 effect effect NN cord-302530-pp6bl941 428 37 on on IN cord-302530-pp6bl941 428 38 the the DT cord-302530-pp6bl941 428 39 probability probability NN cord-302530-pp6bl941 428 40 of of IN cord-302530-pp6bl941 428 41 transmission transmission NN cord-302530-pp6bl941 428 42 at at IN cord-302530-pp6bl941 428 43 low low JJ cord-302530-pp6bl941 428 44 temperatures temperature NNS cord-302530-pp6bl941 428 45 ( ( -LRB- cord-302530-pp6bl941 428 46 Fig Fig NNP cord-302530-pp6bl941 428 47 . . . cord-302530-pp6bl941 428 48 2c 2c NNP cord-302530-pp6bl941 428 49 , , , cord-302530-pp6bl941 428 50 d d NNP cord-302530-pp6bl941 428 51 ) ) -RRB- cord-302530-pp6bl941 428 52 . . . cord-302530-pp6bl941 429 1 This this DT cord-302530-pp6bl941 429 2 is be VBZ cord-302530-pp6bl941 429 3 because because IN cord-302530-pp6bl941 429 4 in in IN cord-302530-pp6bl941 429 5 the the DT cord-302530-pp6bl941 429 6 model model NN cord-302530-pp6bl941 429 7 here here RB cord-302530-pp6bl941 429 8 with with IN cord-302530-pp6bl941 429 9 ΔC ΔC NNP cord-302530-pp6bl941 429 10 p p NN cord-302530-pp6bl941 429 11 in in IN cord-302530-pp6bl941 429 12 the the DT cord-302530-pp6bl941 429 13 range range NN cord-302530-pp6bl941 429 14 of-2.0 of-2.0 NNP cord-302530-pp6bl941 429 15 kJ kJ NNP cord-302530-pp6bl941 429 16 / / SYM cord-302530-pp6bl941 429 17 mol mol NNP cord-302530-pp6bl941 429 18 / / SYM cord-302530-pp6bl941 429 19 K K NNP cord-302530-pp6bl941 429 20 to to IN cord-302530-pp6bl941 429 21 0 0 CD cord-302530-pp6bl941 429 22 kJ kJ NNP cord-302530-pp6bl941 429 23 / / SYM cord-302530-pp6bl941 429 24 mol mol NNP cord-302530-pp6bl941 429 25 / / SYM cord-302530-pp6bl941 429 26 K K NNP cord-302530-pp6bl941 429 27 , , , cord-302530-pp6bl941 429 28 K K NNP cord-302530-pp6bl941 429 29 a_virus_T a_virus_T NNP cord-302530-pp6bl941 429 30 is be VBZ cord-302530-pp6bl941 429 31 high high JJ cord-302530-pp6bl941 429 32 at at IN cord-302530-pp6bl941 429 33 > > XX cord-302530-pp6bl941 429 34 10 10 CD cord-302530-pp6bl941 429 35 14 14 CD cord-302530-pp6bl941 429 36 M M NNP cord-302530-pp6bl941 429 37 − − NNP cord-302530-pp6bl941 429 38 1 1 CD cord-302530-pp6bl941 429 39 at at IN cord-302530-pp6bl941 429 40 low low JJ cord-302530-pp6bl941 429 41 temperatures temperature NNS cord-302530-pp6bl941 429 42 ( ( -LRB- cord-302530-pp6bl941 429 43 Fig Fig NNP cord-302530-pp6bl941 429 44 . . . cord-302530-pp6bl941 429 45 2a 2a CD cord-302530-pp6bl941 429 46 ) ) -RRB- cord-302530-pp6bl941 429 47 and and CC cord-302530-pp6bl941 429 48 thus thus RB cord-302530-pp6bl941 429 49 C.V C.V NNP cord-302530-pp6bl941 429 50 T T NNP cord-302530-pp6bl941 429 51 is be VBZ cord-302530-pp6bl941 429 52 little little RB cord-302530-pp6bl941 429 53 affected affected JJ cord-302530-pp6bl941 429 54 until until IN cord-302530-pp6bl941 429 55 higher high JJR cord-302530-pp6bl941 429 56 temperatures temperature NNS cord-302530-pp6bl941 429 57 ( ( -LRB- cord-302530-pp6bl941 429 58 Fig Fig NNP cord-302530-pp6bl941 429 59 . . . cord-302530-pp6bl941 429 60 2b 2b LS cord-302530-pp6bl941 429 61 ) ) -RRB- cord-302530-pp6bl941 429 62 at at IN cord-302530-pp6bl941 429 63 which which WDT cord-302530-pp6bl941 429 64 K K NNP cord-302530-pp6bl941 429 65 a_virus_T a_virus_T NNP cord-302530-pp6bl941 429 66 falls fall VBZ cord-302530-pp6bl941 429 67 below below IN cord-302530-pp6bl941 429 68 10 10 CD cord-302530-pp6bl941 429 69 14 14 CD cord-302530-pp6bl941 429 70 M M NNP cord-302530-pp6bl941 429 71 − − NNP cord-302530-pp6bl941 429 72 1 1 CD cord-302530-pp6bl941 430 1 ( ( -LRB- cord-302530-pp6bl941 430 2 Fig Fig NNP cord-302530-pp6bl941 430 3 . . . cord-302530-pp6bl941 430 4 2a 2a CD cord-302530-pp6bl941 430 5 ) ) -RRB- cord-302530-pp6bl941 430 6 . . . cord-302530-pp6bl941 431 1 Large large JJ cord-302530-pp6bl941 431 2 negative negative JJ cord-302530-pp6bl941 431 3 values value NNS cord-302530-pp6bl941 431 4 of of IN cord-302530-pp6bl941 431 5 ΔC ΔC NNP cord-302530-pp6bl941 431 6 p p NN cord-302530-pp6bl941 431 7 ( ( -LRB- cord-302530-pp6bl941 431 8 −5.0 −5.0 NNP cord-302530-pp6bl941 431 9 kJ kJ NNP cord-302530-pp6bl941 431 10 / / SYM cord-302530-pp6bl941 431 11 mol mol NNP cord-302530-pp6bl941 431 12 / / SYM cord-302530-pp6bl941 431 13 K K NNP cord-302530-pp6bl941 431 14 ) ) -RRB- cord-302530-pp6bl941 431 15 cause cause VB cord-302530-pp6bl941 431 16 C.V C.V NNP cord-302530-pp6bl941 431 17 T T NNP cord-302530-pp6bl941 431 18 to to TO cord-302530-pp6bl941 431 19 peak peak VB cord-302530-pp6bl941 431 20 rapidly rapidly RB cord-302530-pp6bl941 431 21 falling fall VBG cord-302530-pp6bl941 431 22 at at IN cord-302530-pp6bl941 431 23 lower low JJR cord-302530-pp6bl941 431 24 temperatures temperature NNS cord-302530-pp6bl941 431 25 ( ( -LRB- cord-302530-pp6bl941 431 26 Fig Fig NNP cord-302530-pp6bl941 431 27 . . . cord-302530-pp6bl941 431 28 2b 2b NNP cord-302530-pp6bl941 431 29 ) ) -RRB- cord-302530-pp6bl941 431 30 . . . cord-302530-pp6bl941 432 1 This this DT cord-302530-pp6bl941 432 2 has have VBZ cord-302530-pp6bl941 432 3 a a DT cord-302530-pp6bl941 432 4 large large JJ cord-302530-pp6bl941 432 5 effect effect NN cord-302530-pp6bl941 432 6 on on IN cord-302530-pp6bl941 432 7 the the DT cord-302530-pp6bl941 432 8 predicted predict VBN cord-302530-pp6bl941 432 9 probability probability NN cord-302530-pp6bl941 432 10 of of IN cord-302530-pp6bl941 432 11 transmission transmission NN cord-302530-pp6bl941 432 12 at at IN cord-302530-pp6bl941 432 13 lower low JJR cord-302530-pp6bl941 432 14 temperatures temperature NNS cord-302530-pp6bl941 432 15 with with IN cord-302530-pp6bl941 432 16 p p NN cord-302530-pp6bl941 432 17 transmissionT transmissionT NNP cord-302530-pp6bl941 432 18 44-fold 44-fold CD cord-302530-pp6bl941 432 19 lower low JJR cord-302530-pp6bl941 432 20 at at IN cord-302530-pp6bl941 432 21 10 10 CD cord-302530-pp6bl941 432 22 ° ° NN cord-302530-pp6bl941 432 23 C c NN cord-302530-pp6bl941 432 24 ( ( -LRB- cord-302530-pp6bl941 432 25 Fig Fig NNP cord-302530-pp6bl941 432 26 . . . cord-302530-pp6bl941 432 27 2d 2d NNP cord-302530-pp6bl941 432 28 ) ) -RRB- cord-302530-pp6bl941 432 29 . . . cord-302530-pp6bl941 433 1 It -PRON- PRP cord-302530-pp6bl941 433 2 is be VBZ cord-302530-pp6bl941 433 3 interesting interesting JJ cord-302530-pp6bl941 433 4 to to TO cord-302530-pp6bl941 433 5 note note VB cord-302530-pp6bl941 433 6 that that IN cord-302530-pp6bl941 433 7 ΔC ΔC NNP cord-302530-pp6bl941 433 8 p p NN cord-302530-pp6bl941 433 9 has have VBZ cord-302530-pp6bl941 433 10 little little JJ cord-302530-pp6bl941 433 11 effect effect NN cord-302530-pp6bl941 433 12 on on IN cord-302530-pp6bl941 433 13 p p NN cord-302530-pp6bl941 433 14 transmissionT transmissionT NNP cord-302530-pp6bl941 433 15 over over IN cord-302530-pp6bl941 433 16 the the DT cord-302530-pp6bl941 433 17 range range NN cord-302530-pp6bl941 433 18 of of IN cord-302530-pp6bl941 433 19 temperature temperature NN cord-302530-pp6bl941 433 20 ( ( -LRB- cord-302530-pp6bl941 433 21 23 23 CD cord-302530-pp6bl941 433 22 ° ° NN cord-302530-pp6bl941 433 23 C c NN cord-302530-pp6bl941 433 24 to to IN cord-302530-pp6bl941 433 25 32 32 CD cord-302530-pp6bl941 433 26 ° ° NN cord-302530-pp6bl941 433 27 C C NNP cord-302530-pp6bl941 433 28 ) ) -RRB- cord-302530-pp6bl941 433 29 at at IN cord-302530-pp6bl941 433 30 which which WDT cord-302530-pp6bl941 433 31 laboratory laboratory NN cord-302530-pp6bl941 433 32 vector vector NN cord-302530-pp6bl941 433 33 competence competence NN cord-302530-pp6bl941 433 34 experiments experiment NNS cord-302530-pp6bl941 433 35 ( ( -LRB- cord-302530-pp6bl941 433 36 Liu Liu NNP cord-302530-pp6bl941 433 37 et et NNP cord-302530-pp6bl941 433 38 al al NNP cord-302530-pp6bl941 433 39 . . NNP cord-302530-pp6bl941 433 40 , , , cord-302530-pp6bl941 433 41 2017b 2017b CD cord-302530-pp6bl941 433 42 ) ) -RRB- cord-302530-pp6bl941 433 43 are be VBP cord-302530-pp6bl941 433 44 typically typically RB cord-302530-pp6bl941 433 45 conducted conduct VBN cord-302530-pp6bl941 433 46 ( ( -LRB- cord-302530-pp6bl941 433 47 Fig Fig NNP cord-302530-pp6bl941 433 48 . . . cord-302530-pp6bl941 433 49 2c 2c NNP cord-302530-pp6bl941 433 50 ) ) -RRB- cord-302530-pp6bl941 433 51 . . . cord-302530-pp6bl941 434 1 3.3 3.3 CD cord-302530-pp6bl941 434 2 . . . cord-302530-pp6bl941 435 1 Case case NN cord-302530-pp6bl941 435 2 study study NN cord-302530-pp6bl941 435 3 2 2 CD cord-302530-pp6bl941 435 4 : : : cord-302530-pp6bl941 436 1 The the DT cord-302530-pp6bl941 436 2 magnitude magnitude NN cord-302530-pp6bl941 436 3 of of IN cord-302530-pp6bl941 436 4 ΔC ΔC NNP cord-302530-pp6bl941 436 5 p p NN cord-302530-pp6bl941 436 6 could could MD cord-302530-pp6bl941 436 7 explain explain VB cord-302530-pp6bl941 436 8 the the DT cord-302530-pp6bl941 436 9 temperature temperature NN cord-302530-pp6bl941 436 10 peak peak NN cord-302530-pp6bl941 436 11 observed observe VBN cord-302530-pp6bl941 436 12 in in IN cord-302530-pp6bl941 436 13 the the DT cord-302530-pp6bl941 436 14 specific specific JJ cord-302530-pp6bl941 436 15 binding binding NN cord-302530-pp6bl941 436 16 of of IN cord-302530-pp6bl941 436 17 WEEV WEEV NNP cord-302530-pp6bl941 436 18 to to TO cord-302530-pp6bl941 436 19 susceptible susceptible JJ cord-302530-pp6bl941 436 20 Culex Culex NNP cord-302530-pp6bl941 436 21 tarsalis tarsali NNS cord-302530-pp6bl941 436 22 BBFs BBFs NNP cord-302530-pp6bl941 436 23 With with IN cord-302530-pp6bl941 436 24 a a DT cord-302530-pp6bl941 436 25 ΔC ΔC NNP cord-302530-pp6bl941 436 26 p p NN cord-302530-pp6bl941 436 27 = = SYM cord-302530-pp6bl941 436 28 −3.0 −3.0 NN cord-302530-pp6bl941 436 29 kJ kJ NNP cord-302530-pp6bl941 436 30 / / SYM cord-302530-pp6bl941 436 31 mol mol NNP cord-302530-pp6bl941 436 32 / / SYM cord-302530-pp6bl941 436 33 K K NNP cord-302530-pp6bl941 436 34 the the DT cord-302530-pp6bl941 436 35 magnitude magnitude NN cord-302530-pp6bl941 436 36 of of IN cord-302530-pp6bl941 436 37 K K NNP cord-302530-pp6bl941 436 38 a_virus_T a_virus_T NNP cord-302530-pp6bl941 436 39 between between IN cord-302530-pp6bl941 436 40 0 0 CD cord-302530-pp6bl941 436 41 and and CC cord-302530-pp6bl941 436 42 40 40 CD cord-302530-pp6bl941 436 43 ° ° NN cord-302530-pp6bl941 436 44 C c NN cord-302530-pp6bl941 436 45 is be VBZ cord-302530-pp6bl941 436 46 relatively relatively RB cord-302530-pp6bl941 436 47 constant constant JJ cord-302530-pp6bl941 436 48 compare compare NN cord-302530-pp6bl941 436 49 to to IN cord-302530-pp6bl941 436 50 those those DT cord-302530-pp6bl941 436 51 with with IN cord-302530-pp6bl941 436 52 ΔC ΔC NNP cord-302530-pp6bl941 436 53 p p NN cord-302530-pp6bl941 436 54 = = SYM cord-302530-pp6bl941 436 55 0 0 CD cord-302530-pp6bl941 437 1 kJ kJ NNP cord-302530-pp6bl941 437 2 / / SYM cord-302530-pp6bl941 437 3 mol/ mol/ NNP cord-302530-pp6bl941 437 4 K K NNP cord-302530-pp6bl941 437 5 and and CC cord-302530-pp6bl941 437 6 −5.02 −5.02 NNP cord-302530-pp6bl941 437 7 kJ kJ NNP cord-302530-pp6bl941 437 8 / / SYM cord-302530-pp6bl941 437 9 mol mol NNP cord-302530-pp6bl941 437 10 / / SYM cord-302530-pp6bl941 437 11 K K NNP cord-302530-pp6bl941 437 12 ( ( -LRB- cord-302530-pp6bl941 437 13 Fig Fig NNP cord-302530-pp6bl941 437 14 . . . cord-302530-pp6bl941 437 15 3a 3a LS cord-302530-pp6bl941 437 16 ) ) -RRB- cord-302530-pp6bl941 437 17 varying vary VBG cord-302530-pp6bl941 437 18 by by IN cord-302530-pp6bl941 437 19 only only RB cord-302530-pp6bl941 437 20 40-fold 40-fold CD cord-302530-pp6bl941 437 21 and and CC cord-302530-pp6bl941 437 22 peaking peak VBG cord-302530-pp6bl941 437 23 at at IN cord-302530-pp6bl941 437 24 1.62 1.62 CD cord-302530-pp6bl941 437 25 × × NN cord-302530-pp6bl941 437 26 13 13 CD cord-302530-pp6bl941 437 27 13 13 CD cord-302530-pp6bl941 437 28 M M NNP cord-302530-pp6bl941 437 29 − − NNP cord-302530-pp6bl941 437 30 1 1 CD cord-302530-pp6bl941 437 31 at at IN cord-302530-pp6bl941 437 32 18 18 CD cord-302530-pp6bl941 437 33 ° ° NN cord-302530-pp6bl941 437 34 C c NN cord-302530-pp6bl941 437 35 . . . cord-302530-pp6bl941 438 1 However however RB cord-302530-pp6bl941 438 2 , , , cord-302530-pp6bl941 438 3 this this DT cord-302530-pp6bl941 438 4 variation variation NN cord-302530-pp6bl941 438 5 in in IN cord-302530-pp6bl941 438 6 K K NNP cord-302530-pp6bl941 438 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 438 8 between between IN cord-302530-pp6bl941 438 9 10 10 CD cord-302530-pp6bl941 438 10 12 12 CD cord-302530-pp6bl941 438 11 and and CC cord-302530-pp6bl941 438 12 10 10 CD cord-302530-pp6bl941 438 13 13 13 CD cord-302530-pp6bl941 438 14 M M NNP cord-302530-pp6bl941 438 15 − − NNP cord-302530-pp6bl941 438 16 1 1 CD cord-302530-pp6bl941 438 17 is be VBZ cord-302530-pp6bl941 438 18 optimal optimal JJ cord-302530-pp6bl941 438 19 for for IN cord-302530-pp6bl941 438 20 affecting affect VBG cord-302530-pp6bl941 438 21 the the DT cord-302530-pp6bl941 438 22 number number NN cord-302530-pp6bl941 438 23 of of IN cord-302530-pp6bl941 438 24 midgut midgut NN cord-302530-pp6bl941 438 25 cells cell NNS cord-302530-pp6bl941 438 26 with with IN cord-302530-pp6bl941 438 27 bound bind VBN cord-302530-pp6bl941 438 28 virus virus NN cord-302530-pp6bl941 438 29 ( ( -LRB- cord-302530-pp6bl941 438 30 Fig Fig NNP cord-302530-pp6bl941 438 31 . . . cord-302530-pp6bl941 438 32 3b 3b CD cord-302530-pp6bl941 438 33 ) ) -RRB- cord-302530-pp6bl941 438 34 . . . cord-302530-pp6bl941 439 1 This this DT cord-302530-pp6bl941 439 2 is be VBZ cord-302530-pp6bl941 439 3 because because IN cord-302530-pp6bl941 439 4 K K NNP cord-302530-pp6bl941 439 5 a_virus_T a_virus_T NNP cord-302530-pp6bl941 439 6 is be VBZ cord-302530-pp6bl941 439 7 high high JJ cord-302530-pp6bl941 439 8 enough enough RB cord-302530-pp6bl941 439 9 such such JJ cord-302530-pp6bl941 439 10 that that IN cord-302530-pp6bl941 439 11 a a DT cord-302530-pp6bl941 439 12 significant significant JJ cord-302530-pp6bl941 439 13 proportion proportion NN cord-302530-pp6bl941 439 14 of of IN cord-302530-pp6bl941 439 15 midgut midgut NN cord-302530-pp6bl941 439 16 cells cell NNS cord-302530-pp6bl941 439 17 have have VBP cord-302530-pp6bl941 439 18 bound bind VBN cord-302530-pp6bl941 439 19 virus virus NN cord-302530-pp6bl941 439 20 over over IN cord-302530-pp6bl941 439 21 the the DT cord-302530-pp6bl941 439 22 0 0 CD cord-302530-pp6bl941 439 23 ° ° NN cord-302530-pp6bl941 439 24 C c NN cord-302530-pp6bl941 439 25 to to IN cord-302530-pp6bl941 439 26 40 40 CD cord-302530-pp6bl941 439 27 ° ° NN cord-302530-pp6bl941 439 28 C c NN cord-302530-pp6bl941 439 29 temperature temperature NN cord-302530-pp6bl941 439 30 range range NN cord-302530-pp6bl941 439 31 but but CC cord-302530-pp6bl941 439 32 not not RB cord-302530-pp6bl941 439 33 high high JJ cord-302530-pp6bl941 439 34 enough enough RB cord-302530-pp6bl941 439 35 to to TO cord-302530-pp6bl941 439 36 exceed exceed VB cord-302530-pp6bl941 439 37 the the DT cord-302530-pp6bl941 439 38 10 10 CD cord-302530-pp6bl941 439 39 14 14 CD cord-302530-pp6bl941 439 40 M M NNP cord-302530-pp6bl941 439 41 − − NNP cord-302530-pp6bl941 439 42 1 1 CD cord-302530-pp6bl941 439 43 above above IN cord-302530-pp6bl941 439 44 which which WDT cord-302530-pp6bl941 439 45 all all PDT cord-302530-pp6bl941 439 46 the the DT cord-302530-pp6bl941 439 47 midgut midgut NN cord-302530-pp6bl941 439 48 cells cell NNS cord-302530-pp6bl941 439 49 are be VBP cord-302530-pp6bl941 439 50 saturated saturate VBN cord-302530-pp6bl941 439 51 with with IN cord-302530-pp6bl941 439 52 virus virus NN cord-302530-pp6bl941 439 53 . . . cord-302530-pp6bl941 440 1 The the DT cord-302530-pp6bl941 440 2 variation variation NN cord-302530-pp6bl941 440 3 in in IN cord-302530-pp6bl941 440 4 C.V C.V NNP cord-302530-pp6bl941 440 5 T T NNP cord-302530-pp6bl941 440 6 with with IN cord-302530-pp6bl941 440 7 temperature temperature NN cord-302530-pp6bl941 440 8 with with IN cord-302530-pp6bl941 440 9 ΔC δc NN cord-302530-pp6bl941 440 10 p p NN cord-302530-pp6bl941 440 11 = = SYM cord-302530-pp6bl941 440 12 −3.0 −3.0 NN cord-302530-pp6bl941 440 13 kJ kJ NNP cord-302530-pp6bl941 440 14 / / SYM cord-302530-pp6bl941 440 15 mol mol NNP cord-302530-pp6bl941 440 16 / / SYM cord-302530-pp6bl941 440 17 K K NNP cord-302530-pp6bl941 440 18 shows show VBZ cord-302530-pp6bl941 440 19 some some DT cord-302530-pp6bl941 440 20 similarity similarity NN cord-302530-pp6bl941 440 21 to to IN cord-302530-pp6bl941 440 22 the the DT cord-302530-pp6bl941 440 23 percentage percentage NN cord-302530-pp6bl941 440 24 variation variation NN cord-302530-pp6bl941 440 25 in in IN cord-302530-pp6bl941 440 26 the the DT cord-302530-pp6bl941 440 27 amount amount NN cord-302530-pp6bl941 440 28 of of IN cord-302530-pp6bl941 440 29 WEEV weev NN cord-302530-pp6bl941 440 30 bound bind VBN cord-302530-pp6bl941 440 31 to to IN cord-302530-pp6bl941 440 32 BBFs bbf NNS cord-302530-pp6bl941 440 33 from from IN cord-302530-pp6bl941 440 34 susceptible susceptible JJ cord-302530-pp6bl941 440 35 Culex Culex NNP cord-302530-pp6bl941 440 36 tarsalis tarsalis NNPS cord-302530-pp6bl941 440 37 mosquitoes mosquito NNS cord-302530-pp6bl941 440 38 as as IN cord-302530-pp6bl941 440 39 measured measure VBN cord-302530-pp6bl941 440 40 experimentally experimentally RB cord-302530-pp6bl941 440 41 by by IN cord-302530-pp6bl941 440 42 Houk Houk NNP cord-302530-pp6bl941 440 43 et et NNP cord-302530-pp6bl941 440 44 al al NNP cord-302530-pp6bl941 440 45 . . . cord-302530-pp6bl941 441 1 ( ( -LRB- cord-302530-pp6bl941 441 2 1990 1990 CD cord-302530-pp6bl941 441 3 ) ) -RRB- cord-302530-pp6bl941 441 4 as as IN cord-302530-pp6bl941 441 5 represented represent VBN cord-302530-pp6bl941 441 6 by by IN cord-302530-pp6bl941 441 7 the the DT cord-302530-pp6bl941 441 8 symbols symbol NNS cord-302530-pp6bl941 441 9 in in IN cord-302530-pp6bl941 441 10 Fig Fig NNP cord-302530-pp6bl941 441 11 . . . cord-302530-pp6bl941 441 12 3b 3b CD cord-302530-pp6bl941 441 13 . . . cord-302530-pp6bl941 442 1 According accord VBG cord-302530-pp6bl941 442 2 to to IN cord-302530-pp6bl941 442 3 Houk Houk NNP cord-302530-pp6bl941 442 4 et et NNP cord-302530-pp6bl941 442 5 al al NNP cord-302530-pp6bl941 442 6 . . . cord-302530-pp6bl941 443 1 ( ( -LRB- cord-302530-pp6bl941 443 2 1990 1990 CD cord-302530-pp6bl941 443 3 ) ) -RRB- cord-302530-pp6bl941 443 4 the the DT cord-302530-pp6bl941 443 5 K K NNP cord-302530-pp6bl941 443 6 a_virus_T a_virus_T NNP cord-302530-pp6bl941 443 7 at at IN cord-302530-pp6bl941 443 8 20 20 CD cord-302530-pp6bl941 443 9 ° ° NN cord-302530-pp6bl941 443 10 C c NN cord-302530-pp6bl941 443 11 for for IN cord-302530-pp6bl941 443 12 WEEV weev NN cord-302530-pp6bl941 443 13 binding bind VBG cord-302530-pp6bl941 443 14 to to IN cord-302530-pp6bl941 443 15 BBFs bbf NNS cord-302530-pp6bl941 443 16 from from IN cord-302530-pp6bl941 443 17 susceptible susceptible JJ cord-302530-pp6bl941 443 18 Culex Culex NNP cord-302530-pp6bl941 443 19 tarsalis tarsali NNS cord-302530-pp6bl941 443 20 mosquitoes mosquito NNS cord-302530-pp6bl941 443 21 is be VBZ cord-302530-pp6bl941 443 22 2.2 2.2 CD cord-302530-pp6bl941 443 23 × × CD cord-302530-pp6bl941 443 24 10 10 CD cord-302530-pp6bl941 443 25 11 11 CD cord-302530-pp6bl941 443 26 M M NNP cord-302530-pp6bl941 443 27 − − NNP cord-302530-pp6bl941 443 28 1 1 CD cord-302530-pp6bl941 443 29 . . . cord-302530-pp6bl941 444 1 This this DT cord-302530-pp6bl941 444 2 is be VBZ cord-302530-pp6bl941 444 3 within within IN cord-302530-pp6bl941 444 4 two two CD cord-302530-pp6bl941 444 5 orders order NNS cord-302530-pp6bl941 444 6 of of IN cord-302530-pp6bl941 444 7 magnitude magnitude NN cord-302530-pp6bl941 444 8 of of IN cord-302530-pp6bl941 444 9 the the DT cord-302530-pp6bl941 444 10 value value NN cord-302530-pp6bl941 444 11 of of IN cord-302530-pp6bl941 444 12 1.57 1.57 CD cord-302530-pp6bl941 444 13 × × NN cord-302530-pp6bl941 444 14 10 10 CD cord-302530-pp6bl941 444 15 13 13 CD cord-302530-pp6bl941 444 16 M M NNP cord-302530-pp6bl941 444 17 − − NNP cord-302530-pp6bl941 444 18 1 1 CD cord-302530-pp6bl941 444 19 predicted predict VBD cord-302530-pp6bl941 444 20 by by IN cord-302530-pp6bl941 444 21 the the DT cord-302530-pp6bl941 444 22 model model NN cord-302530-pp6bl941 444 23 here here RB cord-302530-pp6bl941 444 24 with with IN cord-302530-pp6bl941 444 25 ΔC ΔC NNP cord-302530-pp6bl941 444 26 p p NN cord-302530-pp6bl941 444 27 = = SYM cord-302530-pp6bl941 444 28 −3.0 −3.0 NN cord-302530-pp6bl941 444 29 kJ/ kJ/ NNP cord-302530-pp6bl941 444 30 mol mol NNP cord-302530-pp6bl941 444 31 / / SYM cord-302530-pp6bl941 444 32 K K NNP cord-302530-pp6bl941 444 33 ( ( -LRB- cord-302530-pp6bl941 444 34 Fig Fig NNP cord-302530-pp6bl941 444 35 . . . cord-302530-pp6bl941 444 36 3a 3a NNP cord-302530-pp6bl941 444 37 ) ) -RRB- cord-302530-pp6bl941 444 38 . . . cord-302530-pp6bl941 445 1 3.4 3.4 CD cord-302530-pp6bl941 445 2 . . . cord-302530-pp6bl941 446 1 Case case NN cord-302530-pp6bl941 446 2 study study NN cord-302530-pp6bl941 446 3 3 3 CD cord-302530-pp6bl941 446 4 : : : cord-302530-pp6bl941 447 1 A a DT cord-302530-pp6bl941 447 2 large large JJ cord-302530-pp6bl941 447 3 negative negative JJ cord-302530-pp6bl941 447 4 ΔC δc NN cord-302530-pp6bl941 447 5 p p NN cord-302530-pp6bl941 447 6 for for IN cord-302530-pp6bl941 447 7 a a DT cord-302530-pp6bl941 447 8 protein protein NN cord-302530-pp6bl941 447 9 : : : cord-302530-pp6bl941 448 1 protein protein NN cord-302530-pp6bl941 448 2 GP GP NNP cord-302530-pp6bl941 448 3 / / SYM cord-302530-pp6bl941 448 4 Cr cr NN cord-302530-pp6bl941 448 5 system system NN cord-302530-pp6bl941 448 6 as as IN cord-302530-pp6bl941 448 7 represented represent VBN cord-302530-pp6bl941 448 8 by by IN cord-302530-pp6bl941 448 9 HIV HIV NNP cord-302530-pp6bl941 448 10 gp120 gp120 NNP cord-302530-pp6bl941 448 11 : : : cord-302530-pp6bl941 449 1 CD4 CD4 NNP cord-302530-pp6bl941 449 2 diminishes diminish VBZ cord-302530-pp6bl941 449 3 host host NN cord-302530-pp6bl941 449 4 cell cell NN cord-302530-pp6bl941 449 5 binding bind VBG cord-302530-pp6bl941 449 6 at at IN cord-302530-pp6bl941 449 7 higher high JJR cord-302530-pp6bl941 449 8 temperature temperature NN cord-302530-pp6bl941 449 9 3.4.1 3.4.1 NN cord-302530-pp6bl941 449 10 . . . cord-302530-pp6bl941 450 1 Reference reference NN cord-302530-pp6bl941 450 2 temperature temperature NN cord-302530-pp6bl941 450 3 , , , cord-302530-pp6bl941 450 4 T T NNP cord-302530-pp6bl941 450 5 0 0 CD cord-302530-pp6bl941 450 6 , , , cord-302530-pp6bl941 450 7 equals equal VBZ cord-302530-pp6bl941 450 8 37 37 CD cord-302530-pp6bl941 450 9 ° ° NN cord-302530-pp6bl941 451 1 C C NNP cord-302530-pp6bl941 451 2 K K NNP cord-302530-pp6bl941 451 3 a_virus_T a_virus_T NNP cord-302530-pp6bl941 451 4 values value NNS cord-302530-pp6bl941 451 5 for for IN cord-302530-pp6bl941 451 6 HIV HIV NNP cord-302530-pp6bl941 451 7 binding binding NN cord-302530-pp6bl941 451 8 and and CC cord-302530-pp6bl941 452 1 C.V C.V NNP cord-302530-pp6bl941 452 2 T T NNP cord-302530-pp6bl941 452 3 values value NNS cord-302530-pp6bl941 452 4 for for IN cord-302530-pp6bl941 452 5 the the DT cord-302530-pp6bl941 452 6 number number NN cord-302530-pp6bl941 452 7 of of IN cord-302530-pp6bl941 452 8 CD4 CD4 NNP cord-302530-pp6bl941 452 9 + + CC cord-302530-pp6bl941 452 10 T T NNP cord-302530-pp6bl941 452 11 cells cell NNS cord-302530-pp6bl941 452 12 in in IN cord-302530-pp6bl941 452 13 1 1 CD cord-302530-pp6bl941 452 14 mm mm CD cord-302530-pp6bl941 452 15 3 3 CD cord-302530-pp6bl941 452 16 of of IN cord-302530-pp6bl941 452 17 blood blood NN cord-302530-pp6bl941 452 18 with with IN cord-302530-pp6bl941 452 19 bound bind VBN cord-302530-pp6bl941 452 20 HIV HIV NNP cord-302530-pp6bl941 452 21 as as IN cord-302530-pp6bl941 452 22 a a DT cord-302530-pp6bl941 452 23 function function NN cord-302530-pp6bl941 452 24 of of IN cord-302530-pp6bl941 452 25 temperature temperature NN cord-302530-pp6bl941 452 26 are be VBP cord-302530-pp6bl941 452 27 shown show VBN cord-302530-pp6bl941 452 28 in in IN cord-302530-pp6bl941 452 29 Fig Fig NNP cord-302530-pp6bl941 452 30 . . . cord-302530-pp6bl941 452 31 4a 4a CD cord-302530-pp6bl941 452 32 and and CC cord-302530-pp6bl941 452 33 b b LS cord-302530-pp6bl941 452 34 respectively respectively RB cord-302530-pp6bl941 452 35 for for IN cord-302530-pp6bl941 452 36 different different JJ cord-302530-pp6bl941 452 37 ΔC δc NN cord-302530-pp6bl941 452 38 p p NN cord-302530-pp6bl941 452 39 values value NNS cord-302530-pp6bl941 452 40 with with IN cord-302530-pp6bl941 452 41 T t NN cord-302530-pp6bl941 452 42 0 0 CD cord-302530-pp6bl941 452 43 = = NFP cord-302530-pp6bl941 453 1 37 37 CD cord-302530-pp6bl941 453 2 ° ° NN cord-302530-pp6bl941 453 3 C c NN cord-302530-pp6bl941 453 4 . . . cord-302530-pp6bl941 454 1 The the DT cord-302530-pp6bl941 454 2 K K NNP cord-302530-pp6bl941 454 3 a_virus_T a_virus_T NNP cord-302530-pp6bl941 454 4 and and CC cord-302530-pp6bl941 454 5 C.V C.V NNP cord-302530-pp6bl941 454 6 T T NNP cord-302530-pp6bl941 454 7 values value NNS cord-302530-pp6bl941 454 8 in in IN cord-302530-pp6bl941 454 9 Fig Fig NNP cord-302530-pp6bl941 454 10 . . . cord-302530-pp6bl941 454 11 4a 4a CD cord-302530-pp6bl941 454 12 and and CC cord-302530-pp6bl941 454 13 b b LS cord-302530-pp6bl941 454 14 respectively respectively RB cord-302530-pp6bl941 454 15 assume assume VB cord-302530-pp6bl941 454 16 n n NN cord-302530-pp6bl941 454 17 = = SYM cord-302530-pp6bl941 454 18 3 3 CD cord-302530-pp6bl941 454 19 Env env NN cord-302530-pp6bl941 454 20 : : : cord-302530-pp6bl941 455 1 CD4 CD4 NNP cord-302530-pp6bl941 455 2 contacts contact NNS cord-302530-pp6bl941 455 3 with with IN cord-302530-pp6bl941 455 4 thermodynamic thermodynamic JJ cord-302530-pp6bl941 455 5 parameters parameter NNS cord-302530-pp6bl941 455 6 in in IN cord-302530-pp6bl941 456 1 Table table NN cord-302530-pp6bl941 456 2 4 4 CD cord-302530-pp6bl941 456 3 and and CC cord-302530-pp6bl941 456 4 ΔS ΔS NNP cord-302530-pp6bl941 456 5 a_immob a_immob NNP cord-302530-pp6bl941 456 6 = = NFP cord-302530-pp6bl941 457 1 −400 −400 NNP cord-302530-pp6bl941 457 2 J J NNP cord-302530-pp6bl941 457 3 / / SYM cord-302530-pp6bl941 457 4 mol mol NNP cord-302530-pp6bl941 457 5 / / SYM cord-302530-pp6bl941 457 6 K. K. NNP cord-302530-pp6bl941 458 1 The the DT cord-302530-pp6bl941 458 2 large large JJ cord-302530-pp6bl941 458 3 negative negative JJ cord-302530-pp6bl941 458 4 value value NN cord-302530-pp6bl941 458 5 of of IN cord-302530-pp6bl941 458 6 ΔC ΔC NNP cord-302530-pp6bl941 458 7 p p NN cord-302530-pp6bl941 458 8 of of IN cord-302530-pp6bl941 458 9 −5.02 −5.02 NNP cord-302530-pp6bl941 458 10 kJ kJ NNP cord-302530-pp6bl941 458 11 / / SYM cord-302530-pp6bl941 458 12 mol mol NNP cord-302530-pp6bl941 458 13 / / SYM cord-302530-pp6bl941 458 14 K K NNP cord-302530-pp6bl941 458 15 reported report VBD cord-302530-pp6bl941 458 16 for for IN cord-302530-pp6bl941 458 17 gp120 gp120 NNP cord-302530-pp6bl941 458 18 : : : cord-302530-pp6bl941 459 1 CD4 CD4 NNP cord-302530-pp6bl941 459 2 ( ( -LRB- cord-302530-pp6bl941 459 3 Table Table NNP cord-302530-pp6bl941 459 4 3 3 CD cord-302530-pp6bl941 459 5 ) ) -RRB- cord-302530-pp6bl941 459 6 diminishes diminish VBZ cord-302530-pp6bl941 459 7 binding bind VBG cord-302530-pp6bl941 459 8 at at IN cord-302530-pp6bl941 459 9 higher high JJR cord-302530-pp6bl941 459 10 temperatures temperature NNS cord-302530-pp6bl941 459 11 compared compare VBN cord-302530-pp6bl941 459 12 to to IN cord-302530-pp6bl941 459 13 ΔC ΔC NNP cord-302530-pp6bl941 459 14 p p NN cord-302530-pp6bl941 459 15 of of IN cord-302530-pp6bl941 459 16 0 0 CD cord-302530-pp6bl941 459 17 kJ kJ NNP cord-302530-pp6bl941 459 18 / / SYM cord-302530-pp6bl941 459 19 mol/ mol/ NNP cord-302530-pp6bl941 460 1 K. K. NNP cord-302530-pp6bl941 460 2 Thus thus RB cord-302530-pp6bl941 460 3 from from IN cord-302530-pp6bl941 460 4 Fig Fig NNP cord-302530-pp6bl941 460 5 . . . cord-302530-pp6bl941 461 1 4b 4b CD cord-302530-pp6bl941 461 2 , , , cord-302530-pp6bl941 461 3 only only RB cord-302530-pp6bl941 461 4 half half NN cord-302530-pp6bl941 461 5 of of IN cord-302530-pp6bl941 461 6 the the DT cord-302530-pp6bl941 461 7 1000 1000 CD cord-302530-pp6bl941 461 8 cells cell NNS cord-302530-pp6bl941 461 9 have have VBP cord-302530-pp6bl941 461 10 bound bind VBN cord-302530-pp6bl941 461 11 virus virus NN cord-302530-pp6bl941 461 12 at at IN cord-302530-pp6bl941 461 13 12 12 CD cord-302530-pp6bl941 461 14 ° ° NN cord-302530-pp6bl941 461 15 C c NN cord-302530-pp6bl941 461 16 with with IN cord-302530-pp6bl941 461 17 ΔC δc NN cord-302530-pp6bl941 461 18 p p NN cord-302530-pp6bl941 461 19 = = NN cord-302530-pp6bl941 461 20 −5.02 −5.02 NNP cord-302530-pp6bl941 461 21 kJ kJ NNP cord-302530-pp6bl941 461 22 / / SYM cord-302530-pp6bl941 461 23 mol mol NNP cord-302530-pp6bl941 461 24 / / SYM cord-302530-pp6bl941 461 25 K K NNP cord-302530-pp6bl941 461 26 while while NN cord-302530-pp6bl941 461 27 with with IN cord-302530-pp6bl941 461 28 ΔC ΔC NNP cord-302530-pp6bl941 461 29 p p NN cord-302530-pp6bl941 461 30 = = SYM cord-302530-pp6bl941 461 31 0 0 CD cord-302530-pp6bl941 461 32 kJ kJ NNP cord-302530-pp6bl941 461 33 / / SYM cord-302530-pp6bl941 461 34 mol mol NNP cord-302530-pp6bl941 461 35 / / SYM cord-302530-pp6bl941 461 36 K K NNP cord-302530-pp6bl941 461 37 half half NN cord-302530-pp6bl941 461 38 the the DT cord-302530-pp6bl941 461 39 cells cell NNS cord-302530-pp6bl941 461 40 still still RB cord-302530-pp6bl941 461 41 have have VBP cord-302530-pp6bl941 461 42 bound bind VBN cord-302530-pp6bl941 461 43 virus virus NN cord-302530-pp6bl941 461 44 at at IN cord-302530-pp6bl941 461 45 a a DT cord-302530-pp6bl941 461 46 temperature temperature NN cord-302530-pp6bl941 461 47 of of IN cord-302530-pp6bl941 461 48 6 6 CD cord-302530-pp6bl941 461 49 ° ° NN cord-302530-pp6bl941 461 50 C c NN cord-302530-pp6bl941 461 51 higher high JJR cord-302530-pp6bl941 461 52 ( ( -LRB- cord-302530-pp6bl941 461 53 18 18 CD cord-302530-pp6bl941 461 54 ° ° NN cord-302530-pp6bl941 461 55 C C NNP cord-302530-pp6bl941 461 56 ) ) -RRB- cord-302530-pp6bl941 461 57 . . . cord-302530-pp6bl941 462 1 With with IN cord-302530-pp6bl941 462 2 ΔC δc NN cord-302530-pp6bl941 462 3 p p NN cord-302530-pp6bl941 462 4 = = NN cord-302530-pp6bl941 462 5 −5.02 −5.02 NNP cord-302530-pp6bl941 462 6 kJ kJ NNP cord-302530-pp6bl941 462 7 / / SYM cord-302530-pp6bl941 462 8 mol mol NNP cord-302530-pp6bl941 462 9 / / SYM cord-302530-pp6bl941 462 10 K K NNP cord-302530-pp6bl941 462 11 , , , cord-302530-pp6bl941 462 12 C.V C.V NNP cord-302530-pp6bl941 462 13 T T NNP cord-302530-pp6bl941 462 14 is be VBZ cord-302530-pp6bl941 462 15 < < NNP cord-302530-pp6bl941 462 16 1 1 CD cord-302530-pp6bl941 462 17 cell cell NN cord-302530-pp6bl941 462 18 ( ( -LRB- cord-302530-pp6bl941 462 19 i.e. i.e. FW cord-302530-pp6bl941 462 20 no no DT cord-302530-pp6bl941 462 21 virus virus NN cord-302530-pp6bl941 462 22 bound bind VBN cord-302530-pp6bl941 462 23 ) ) -RRB- cord-302530-pp6bl941 462 24 at at IN cord-302530-pp6bl941 462 25 22 22 CD cord-302530-pp6bl941 462 26 ° ° NN cord-302530-pp6bl941 462 27 C c NN cord-302530-pp6bl941 462 28 while while IN cord-302530-pp6bl941 462 29 with with IN cord-302530-pp6bl941 462 30 ΔC ΔC NNP cord-302530-pp6bl941 462 31 p p NN cord-302530-pp6bl941 462 32 = = SYM cord-302530-pp6bl941 462 33 0 0 CD cord-302530-pp6bl941 462 34 kJ kJ NNP cord-302530-pp6bl941 462 35 / / SYM cord-302530-pp6bl941 462 36 mol mol NNP cord-302530-pp6bl941 462 37 / / SYM cord-302530-pp6bl941 462 38 K K NNP cord-302530-pp6bl941 462 39 the the DT cord-302530-pp6bl941 462 40 slightly slightly RB cord-302530-pp6bl941 462 41 higher high JJR cord-302530-pp6bl941 462 42 temperature temperature NN cord-302530-pp6bl941 462 43 of of IN cord-302530-pp6bl941 462 44 24 24 CD cord-302530-pp6bl941 462 45 ° ° NN cord-302530-pp6bl941 462 46 C C NNP cord-302530-pp6bl941 462 47 is be VBZ cord-302530-pp6bl941 462 48 required require VBN cord-302530-pp6bl941 462 49 to to TO cord-302530-pp6bl941 462 50 decrease decrease VB cord-302530-pp6bl941 462 51 C.V C.V NNP cord-302530-pp6bl941 462 52 T T NNP cord-302530-pp6bl941 462 53 to to IN cord-302530-pp6bl941 462 54 < < XX cord-302530-pp6bl941 462 55 1 1 CD cord-302530-pp6bl941 462 56 cell cell NN cord-302530-pp6bl941 462 57 ( ( -LRB- cord-302530-pp6bl941 462 58 Fig Fig NNP cord-302530-pp6bl941 462 59 . . . cord-302530-pp6bl941 462 60 4b 4b CD cord-302530-pp6bl941 462 61 ) ) -RRB- cord-302530-pp6bl941 462 62 . . . cord-302530-pp6bl941 463 1 The the DT cord-302530-pp6bl941 463 2 three three CD cord-302530-pp6bl941 463 3 lines line NNS cord-302530-pp6bl941 463 4 representing represent VBG cord-302530-pp6bl941 463 5 K K NNP cord-302530-pp6bl941 463 6 a_virus_T a_virus_T NNP cord-302530-pp6bl941 463 7 for for IN cord-302530-pp6bl941 463 8 different different JJ cord-302530-pp6bl941 463 9 values value NNS cord-302530-pp6bl941 463 10 of of IN cord-302530-pp6bl941 463 11 ΔC ΔC NNP cord-302530-pp6bl941 463 12 p p NN cord-302530-pp6bl941 463 13 in in IN cord-302530-pp6bl941 463 14 Fig Fig NNP cord-302530-pp6bl941 463 15 . . . cord-302530-pp6bl941 464 1 4a 4a CD cord-302530-pp6bl941 464 2 intercept intercept VBP cord-302530-pp6bl941 464 3 at at IN cord-302530-pp6bl941 464 4 37 37 CD cord-302530-pp6bl941 464 5 ° ° NN cord-302530-pp6bl941 464 6 C c NN cord-302530-pp6bl941 464 7 ( ( -LRB- cord-302530-pp6bl941 464 8 T T NNP cord-302530-pp6bl941 464 9 0 0 CD cord-302530-pp6bl941 464 10 ) ) -RRB- cord-302530-pp6bl941 464 11 and and CC cord-302530-pp6bl941 464 12 would would MD cord-302530-pp6bl941 464 13 do do VB cord-302530-pp6bl941 464 14 for for IN cord-302530-pp6bl941 464 15 C.V C.V NNP cord-302530-pp6bl941 464 16 T T NNP cord-302530-pp6bl941 464 17 in in IN cord-302530-pp6bl941 464 18 Fig Fig NNP cord-302530-pp6bl941 464 19 . . . cord-302530-pp6bl941 464 20 4b 4b CD cord-302530-pp6bl941 464 21 if if IN cord-302530-pp6bl941 464 22 extrapolated extrapolate VBN cord-302530-pp6bl941 464 23 to to IN cord-302530-pp6bl941 464 24 37 37 CD cord-302530-pp6bl941 464 25 ° ° NN cord-302530-pp6bl941 464 26 C c NN cord-302530-pp6bl941 464 27 . . . cord-302530-pp6bl941 465 1 To to TO cord-302530-pp6bl941 465 2 demonstrate demonstrate VB cord-302530-pp6bl941 465 3 how how WRB cord-302530-pp6bl941 465 4 the the DT cord-302530-pp6bl941 465 5 magnitude magnitude NN cord-302530-pp6bl941 465 6 of of IN cord-302530-pp6bl941 465 7 ΔC ΔC NNP cord-302530-pp6bl941 465 8 p p NN cord-302530-pp6bl941 465 9 affects affect VBZ cord-302530-pp6bl941 465 10 K K NNP cord-302530-pp6bl941 465 11 a_virus_T a_virus_T NNP cord-302530-pp6bl941 465 12 at at IN cord-302530-pp6bl941 465 13 temperatures temperature NNS cord-302530-pp6bl941 465 14 of of IN cord-302530-pp6bl941 465 15 37 37 CD cord-302530-pp6bl941 465 16 ° ° NN cord-302530-pp6bl941 465 17 C C NNP cord-302530-pp6bl941 465 18 representing represent VBG cord-302530-pp6bl941 465 19 mammalian mammalian JJ cord-302530-pp6bl941 465 20 body body NN cord-302530-pp6bl941 465 21 temperature temperature NN cord-302530-pp6bl941 465 22 , , , cord-302530-pp6bl941 465 23 the the DT cord-302530-pp6bl941 465 24 reference reference NN cord-302530-pp6bl941 465 25 temperature temperature NN cord-302530-pp6bl941 465 26 is be VBZ cord-302530-pp6bl941 465 27 set set VBN cord-302530-pp6bl941 465 28 to to IN cord-302530-pp6bl941 465 29 4 4 CD cord-302530-pp6bl941 465 30 ° ° NN cord-302530-pp6bl941 465 31 C c NN cord-302530-pp6bl941 465 32 such such JJ cord-302530-pp6bl941 465 33 that that IN cord-302530-pp6bl941 465 34 the the DT cord-302530-pp6bl941 465 35 three three CD cord-302530-pp6bl941 465 36 plots plot NNS cord-302530-pp6bl941 465 37 for for IN cord-302530-pp6bl941 465 38 K K NNP cord-302530-pp6bl941 465 39 a_virus_T a_virus_T NNP cord-302530-pp6bl941 465 40 intercept intercept VB cord-302530-pp6bl941 465 41 at at IN cord-302530-pp6bl941 465 42 4 4 CD cord-302530-pp6bl941 465 43 ° ° NN cord-302530-pp6bl941 465 44 C c NN cord-302530-pp6bl941 465 45 in in IN cord-302530-pp6bl941 465 46 Fig Fig NNP cord-302530-pp6bl941 465 47 . . . cord-302530-pp6bl941 466 1 4c 4c LS cord-302530-pp6bl941 466 2 with with IN cord-302530-pp6bl941 466 3 much much RB cord-302530-pp6bl941 466 4 lower low JJR cord-302530-pp6bl941 466 5 K K NNP cord-302530-pp6bl941 466 6 a_virus_T a_virus_T NNP cord-302530-pp6bl941 466 7 values value NNS cord-302530-pp6bl941 466 8 predicted predict VBD cord-302530-pp6bl941 466 9 at at IN cord-302530-pp6bl941 466 10 37 37 CD cord-302530-pp6bl941 466 11 ° ° NN cord-302530-pp6bl941 466 12 C c NN cord-302530-pp6bl941 466 13 with with IN cord-302530-pp6bl941 466 14 a a DT cord-302530-pp6bl941 466 15 large large JJ cord-302530-pp6bl941 466 16 negative negative JJ cord-302530-pp6bl941 466 17 ΔC δc NN cord-302530-pp6bl941 466 18 p p NN cord-302530-pp6bl941 467 1 than than IN cord-302530-pp6bl941 467 2 for for IN cord-302530-pp6bl941 467 3 a a DT cord-302530-pp6bl941 467 4 system system NN cord-302530-pp6bl941 467 5 with with IN cord-302530-pp6bl941 467 6 ΔC ΔC NNP cord-302530-pp6bl941 467 7 p p NN cord-302530-pp6bl941 467 8 = = SYM cord-302530-pp6bl941 467 9 0 0 CD cord-302530-pp6bl941 467 10 kJ kJ NNP cord-302530-pp6bl941 467 11 / / SYM cord-302530-pp6bl941 467 12 mol mol NNP cord-302530-pp6bl941 467 13 / / SYM cord-302530-pp6bl941 467 14 K. K. NNP cord-302530-pp6bl941 468 1 The the DT cord-302530-pp6bl941 468 2 effect effect NN cord-302530-pp6bl941 468 3 of of IN cord-302530-pp6bl941 468 4 ΔC ΔC NNP cord-302530-pp6bl941 468 5 p p NN cord-302530-pp6bl941 468 6 on on IN cord-302530-pp6bl941 468 7 the the DT cord-302530-pp6bl941 468 8 number number NN cord-302530-pp6bl941 468 9 of of IN cord-302530-pp6bl941 468 10 cells cell NNS cord-302530-pp6bl941 468 11 with with IN cord-302530-pp6bl941 468 12 bound bind VBN cord-302530-pp6bl941 468 13 virus virus NN cord-302530-pp6bl941 468 14 at at IN cord-302530-pp6bl941 468 15 higher high JJR cord-302530-pp6bl941 468 16 temperatures temperature NNS cord-302530-pp6bl941 468 17 is be VBZ cord-302530-pp6bl941 468 18 considerable considerable JJ cord-302530-pp6bl941 468 19 with with IN cord-302530-pp6bl941 468 20 C.V C.V NNP cord-302530-pp6bl941 468 21 T T NNP cord-302530-pp6bl941 468 22 reduced reduce VBN cord-302530-pp6bl941 468 23 to to IN cord-302530-pp6bl941 468 24 1 1 CD cord-302530-pp6bl941 468 25 cell cell NN cord-302530-pp6bl941 468 26 at at IN cord-302530-pp6bl941 468 27 22 22 CD cord-302530-pp6bl941 468 28 ° ° NN cord-302530-pp6bl941 468 29 C c NN cord-302530-pp6bl941 468 30 with with IN cord-302530-pp6bl941 468 31 ΔC δc NN cord-302530-pp6bl941 468 32 p p NN cord-302530-pp6bl941 468 33 = = NN cord-302530-pp6bl941 468 34 −5.02 −5.02 NNP cord-302530-pp6bl941 468 35 kJ kJ NNP cord-302530-pp6bl941 468 36 / / SYM cord-302530-pp6bl941 468 37 mol mol NNP cord-302530-pp6bl941 468 38 / / SYM cord-302530-pp6bl941 468 39 K K NNP cord-302530-pp6bl941 468 40 compared compare VBD cord-302530-pp6bl941 468 41 to to IN cord-302530-pp6bl941 468 42 31 31 CD cord-302530-pp6bl941 468 43 ° ° NN cord-302530-pp6bl941 468 44 C c NN cord-302530-pp6bl941 468 45 with with IN cord-302530-pp6bl941 468 46 ΔC δc NN cord-302530-pp6bl941 468 47 p p NN cord-302530-pp6bl941 468 48 = = SYM cord-302530-pp6bl941 468 49 0 0 CD cord-302530-pp6bl941 468 50 kJ kJ NNP cord-302530-pp6bl941 468 51 / / SYM cord-302530-pp6bl941 468 52 mol mol NNP cord-302530-pp6bl941 468 53 / / SYM cord-302530-pp6bl941 468 54 K K NNP cord-302530-pp6bl941 468 55 ( ( -LRB- cord-302530-pp6bl941 468 56 Fig Fig NNP cord-302530-pp6bl941 468 57 . . . cord-302530-pp6bl941 468 58 4d 4d CD cord-302530-pp6bl941 468 59 ) ) -RRB- cord-302530-pp6bl941 468 60 . . . cord-302530-pp6bl941 469 1 It -PRON- PRP cord-302530-pp6bl941 469 2 should should MD cord-302530-pp6bl941 469 3 be be VB cord-302530-pp6bl941 469 4 noted note VBN cord-302530-pp6bl941 469 5 that that IN cord-302530-pp6bl941 469 6 the the DT cord-302530-pp6bl941 469 7 dashed dash VBN cord-302530-pp6bl941 469 8 lines line NNS cord-302530-pp6bl941 469 9 in in IN cord-302530-pp6bl941 469 10 Fig Fig NNP cord-302530-pp6bl941 469 11 . . . cord-302530-pp6bl941 470 1 4c 4c NNP cord-302530-pp6bl941 470 2 and and CC cord-302530-pp6bl941 470 3 d d NNP cord-302530-pp6bl941 470 4 are be VBP cord-302530-pp6bl941 470 5 the the DT cord-302530-pp6bl941 470 6 same same JJ cord-302530-pp6bl941 470 7 as as IN cord-302530-pp6bl941 470 8 those those DT cord-302530-pp6bl941 470 9 in in IN cord-302530-pp6bl941 470 10 Fig Fig NNP cord-302530-pp6bl941 470 11 . . . cord-302530-pp6bl941 470 12 4a 4a CD cord-302530-pp6bl941 470 13 and and CC cord-302530-pp6bl941 470 14 b b LS cord-302530-pp6bl941 470 15 respectively respectively RB cord-302530-pp6bl941 470 16 being be VBG cord-302530-pp6bl941 470 17 based base VBN cord-302530-pp6bl941 470 18 on on IN cord-302530-pp6bl941 470 19 experimental experimental JJ cord-302530-pp6bl941 470 20 data datum NNS cord-302530-pp6bl941 470 21 for for IN cord-302530-pp6bl941 470 22 HIV HIV NNP cord-302530-pp6bl941 470 23 gp120 gp120 NNP cord-302530-pp6bl941 470 24 : : : cord-302530-pp6bl941 471 1 CD4 CD4 NNP cord-302530-pp6bl941 471 2 ( ( -LRB- cord-302530-pp6bl941 471 3 Fig Fig NNP cord-302530-pp6bl941 471 4 . . . cord-302530-pp6bl941 471 5 1 1 CD cord-302530-pp6bl941 471 6 ) ) -RRB- cord-302530-pp6bl941 471 7 . . . cord-302530-pp6bl941 472 1 The the DT cord-302530-pp6bl941 472 2 purpose purpose NN cord-302530-pp6bl941 472 3 of of IN cord-302530-pp6bl941 472 4 the the DT cord-302530-pp6bl941 472 5 dotted dotted JJ cord-302530-pp6bl941 472 6 and and CC cord-302530-pp6bl941 472 7 solid solid JJ cord-302530-pp6bl941 472 8 lines line NNS cord-302530-pp6bl941 472 9 is be VBZ cord-302530-pp6bl941 472 10 merely merely RB cord-302530-pp6bl941 472 11 to to TO cord-302530-pp6bl941 472 12 illustrate illustrate VB cord-302530-pp6bl941 472 13 the the DT cord-302530-pp6bl941 472 14 effect effect NN cord-302530-pp6bl941 472 15 of of IN cord-302530-pp6bl941 472 16 less less RBR cord-302530-pp6bl941 472 17 negative negative JJ cord-302530-pp6bl941 472 18 ΔC ΔC NNP cord-302530-pp6bl941 472 19 p p NN cord-302530-pp6bl941 472 20 increasing increase VBG cord-302530-pp6bl941 472 21 the the DT cord-302530-pp6bl941 472 22 binding binding NN cord-302530-pp6bl941 472 23 at at IN cord-302530-pp6bl941 472 24 higher high JJR cord-302530-pp6bl941 472 25 temperatures temperature NNS cord-302530-pp6bl941 472 26 for for IN cord-302530-pp6bl941 472 27 the the DT cord-302530-pp6bl941 472 28 purpose purpose NN cord-302530-pp6bl941 472 29 of of IN cord-302530-pp6bl941 472 30 understanding understanding NN cord-302530-pp6bl941 472 31 . . . cord-302530-pp6bl941 473 1 3.5 3.5 CD cord-302530-pp6bl941 473 2 . . . cord-302530-pp6bl941 474 1 Case case NN cord-302530-pp6bl941 474 2 study study NN cord-302530-pp6bl941 474 3 4 4 CD cord-302530-pp6bl941 474 4 : : : cord-302530-pp6bl941 475 1 A a DT cord-302530-pp6bl941 475 2 large large JJ cord-302530-pp6bl941 475 3 virus virus NN cord-302530-pp6bl941 475 4 diameter diameter NN cord-302530-pp6bl941 475 5 as as IN cord-302530-pp6bl941 475 6 for for IN cord-302530-pp6bl941 475 7 the the DT cord-302530-pp6bl941 475 8 HIV HIV NNP cord-302530-pp6bl941 475 9 virion virion NN cord-302530-pp6bl941 475 10 diminishes diminish VBZ cord-302530-pp6bl941 475 11 host host NN cord-302530-pp6bl941 475 12 cell cell NN cord-302530-pp6bl941 475 13 binding bind VBG cord-302530-pp6bl941 475 14 at at IN cord-302530-pp6bl941 475 15 the the DT cord-302530-pp6bl941 475 16 higher high JJR cord-302530-pp6bl941 475 17 temperature temperature NN cord-302530-pp6bl941 475 18 of of IN cord-302530-pp6bl941 475 19 the the DT cord-302530-pp6bl941 475 20 human human JJ cord-302530-pp6bl941 475 21 body body NN cord-302530-pp6bl941 475 22 through through IN cord-302530-pp6bl941 475 23 the the DT cord-302530-pp6bl941 475 24 large large JJ cord-302530-pp6bl941 475 25 negative negative JJ cord-302530-pp6bl941 475 26 ΔS ΔS NNP cord-302530-pp6bl941 475 27 a_immob a_immob NN cord-302530-pp6bl941 476 1 From from IN cord-302530-pp6bl941 476 2 Eq Eq NNP cord-302530-pp6bl941 476 3 . . . cord-302530-pp6bl941 477 1 ( ( -LRB- cord-302530-pp6bl941 477 2 18 18 CD cord-302530-pp6bl941 477 3 ) ) -RRB- cord-302530-pp6bl941 477 4 , , , cord-302530-pp6bl941 477 5 ΔS ΔS NNP cord-302530-pp6bl941 477 6 a_immob a_immob NNP cord-302530-pp6bl941 477 7 becomes become VBZ cord-302530-pp6bl941 477 8 more more RBR cord-302530-pp6bl941 477 9 negative negative JJ cord-302530-pp6bl941 477 10 as as IN cord-302530-pp6bl941 477 11 the the DT cord-302530-pp6bl941 477 12 diameter diameter NN cord-302530-pp6bl941 477 13 of of IN cord-302530-pp6bl941 477 14 the the DT cord-302530-pp6bl941 477 15 virus virus NN cord-302530-pp6bl941 477 16 increases increase VBZ cord-302530-pp6bl941 477 17 . . . cord-302530-pp6bl941 478 1 The the DT cord-302530-pp6bl941 478 2 value value NN cord-302530-pp6bl941 478 3 of of IN cord-302530-pp6bl941 478 4 K K NNP cord-302530-pp6bl941 478 5 a_virus_T a_virus_T NNP cord-302530-pp6bl941 478 6 decreases decrease VBZ cord-302530-pp6bl941 478 7 with with IN cord-302530-pp6bl941 478 8 increasing increase VBG cord-302530-pp6bl941 478 9 temperature temperature NN cord-302530-pp6bl941 478 10 in in IN cord-302530-pp6bl941 478 11 Fig Fig NNP cord-302530-pp6bl941 478 12 . . . cord-302530-pp6bl941 479 1 5a 5a LS cord-302530-pp6bl941 480 1 while while IN cord-302530-pp6bl941 480 2 more more JJR cord-302530-pp6bl941 480 3 negative negative JJ cord-302530-pp6bl941 480 4 values value NNS cord-302530-pp6bl941 480 5 of of IN cord-302530-pp6bl941 480 6 ΔS ΔS NNP cord-302530-pp6bl941 480 7 a_immob a_immob NNP cord-302530-pp6bl941 480 8 merely merely RB cord-302530-pp6bl941 480 9 shift shift VBP cord-302530-pp6bl941 480 10 each each DT cord-302530-pp6bl941 480 11 parallel parallel JJ cord-302530-pp6bl941 480 12 curve curve NN cord-302530-pp6bl941 480 13 to to TO cord-302530-pp6bl941 480 14 lower lower VB cord-302530-pp6bl941 480 15 K K NNP cord-302530-pp6bl941 480 16 a_virus_T a_virus_T NNP cord-302530-pp6bl941 480 17 values value NNS cord-302530-pp6bl941 480 18 as as IN cord-302530-pp6bl941 480 19 expected expect VBN cord-302530-pp6bl941 480 20 from from IN cord-302530-pp6bl941 480 21 Eq Eq NNP cord-302530-pp6bl941 480 22 . . . cord-302530-pp6bl941 481 1 ( ( -LRB- cord-302530-pp6bl941 481 2 17 17 CD cord-302530-pp6bl941 481 3 ) ) -RRB- cord-302530-pp6bl941 481 4 such such JJ cord-302530-pp6bl941 481 5 that that IN cord-302530-pp6bl941 481 6 K K NNP cord-302530-pp6bl941 481 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 481 8 falls fall VBZ cord-302530-pp6bl941 481 9 below below IN cord-302530-pp6bl941 481 10 10 10 CD cord-302530-pp6bl941 481 11 14 14 CD cord-302530-pp6bl941 481 12 M M NNP cord-302530-pp6bl941 481 13 − − NNP cord-302530-pp6bl941 481 14 1 1 CD cord-302530-pp6bl941 481 15 at at IN cord-302530-pp6bl941 481 16 progressively progressively RB cord-302530-pp6bl941 481 17 lower low JJR cord-302530-pp6bl941 481 18 temperatures temperature NNS cord-302530-pp6bl941 481 19 . . . cord-302530-pp6bl941 482 1 Values value NNS cord-302530-pp6bl941 482 2 of of IN cord-302530-pp6bl941 482 3 C.V C.V NNP cord-302530-pp6bl941 482 4 T T NNP cord-302530-pp6bl941 482 5 with with IN cord-302530-pp6bl941 482 6 ΔS ΔS NNP cord-302530-pp6bl941 482 7 a_immob a_immob NNP cord-302530-pp6bl941 482 8 decreasing decrease VBG cord-302530-pp6bl941 482 9 from from IN cord-302530-pp6bl941 482 10 −240 −240 NNP cord-302530-pp6bl941 482 11 J/ J/ NNP cord-302530-pp6bl941 482 12 mol mol NN cord-302530-pp6bl941 482 13 / / SYM cord-302530-pp6bl941 482 14 K K NNP cord-302530-pp6bl941 482 15 to to IN cord-302530-pp6bl941 482 16 −400 −400 NNP cord-302530-pp6bl941 482 17 J J NNP cord-302530-pp6bl941 482 18 / / SYM cord-302530-pp6bl941 482 19 mol mol NNP cord-302530-pp6bl941 482 20 / / SYM cord-302530-pp6bl941 482 21 K K NNP cord-302530-pp6bl941 482 22 in in IN cord-302530-pp6bl941 482 23 steps step NNS cord-302530-pp6bl941 482 24 of of IN cord-302530-pp6bl941 482 25 18.6 18.6 CD cord-302530-pp6bl941 482 26 % % NN cord-302530-pp6bl941 482 27 are be VBP cord-302530-pp6bl941 482 28 plotted plot VBN cord-302530-pp6bl941 482 29 in in IN cord-302530-pp6bl941 482 30 Fig Fig NNP cord-302530-pp6bl941 482 31 . . . cord-302530-pp6bl941 483 1 5b 5b CD cord-302530-pp6bl941 483 2 and and CC cord-302530-pp6bl941 483 3 show show VB cord-302530-pp6bl941 483 4 that that IN cord-302530-pp6bl941 483 5 the the DT cord-302530-pp6bl941 483 6 number number NN cord-302530-pp6bl941 483 7 of of IN cord-302530-pp6bl941 483 8 cells cell NNS cord-302530-pp6bl941 483 9 with with IN cord-302530-pp6bl941 483 10 bound bind VBN cord-302530-pp6bl941 483 11 virus virus NN cord-302530-pp6bl941 483 12 falls fall VBZ cord-302530-pp6bl941 483 13 to to IN cord-302530-pp6bl941 483 14 < < XX cord-302530-pp6bl941 483 15 1 1 CD cord-302530-pp6bl941 483 16 at at IN cord-302530-pp6bl941 483 17 progressively progressively RB cord-302530-pp6bl941 483 18 lower low JJR cord-302530-pp6bl941 483 19 temperature temperature NN cord-302530-pp6bl941 483 20 as as IN cord-302530-pp6bl941 483 21 ΔS ΔS NNP cord-302530-pp6bl941 483 22 a_immob a_immob NNP cord-302530-pp6bl941 483 23 becomes become VBZ cord-302530-pp6bl941 483 24 more more RBR cord-302530-pp6bl941 483 25 negative negative JJ cord-302530-pp6bl941 483 26 through through IN cord-302530-pp6bl941 483 27 increasing increase VBG cord-302530-pp6bl941 483 28 the the DT cord-302530-pp6bl941 483 29 virus virus NN cord-302530-pp6bl941 483 30 diameter diameter NN cord-302530-pp6bl941 483 31 . . . cord-302530-pp6bl941 484 1 The the DT cord-302530-pp6bl941 484 2 temperature temperature NN cord-302530-pp6bl941 484 3 at at IN cord-302530-pp6bl941 484 4 which which WDT cord-302530-pp6bl941 484 5 C.V C.V NNP cord-302530-pp6bl941 484 6 T T NNP cord-302530-pp6bl941 484 7 falls fall VBZ cord-302530-pp6bl941 484 8 to to IN cord-302530-pp6bl941 484 9 < < XX cord-302530-pp6bl941 484 10 1 1 CD cord-302530-pp6bl941 484 11 is be VBZ cord-302530-pp6bl941 484 12 predicted predict VBN cord-302530-pp6bl941 484 13 to to TO cord-302530-pp6bl941 484 14 increase increase VB cord-302530-pp6bl941 484 15 from from IN cord-302530-pp6bl941 484 16 22 22 CD cord-302530-pp6bl941 484 17 ° ° NN cord-302530-pp6bl941 484 18 C c NN cord-302530-pp6bl941 484 19 to to IN cord-302530-pp6bl941 484 20 43 43 CD cord-302530-pp6bl941 484 21 ° ° NN cord-302530-pp6bl941 484 22 C c NN cord-302530-pp6bl941 484 23 as as IN cord-302530-pp6bl941 484 24 ΔS ΔS NNP cord-302530-pp6bl941 484 25 a_immob a_immob NNP cord-302530-pp6bl941 484 26 increases increase VBZ cord-302530-pp6bl941 484 27 in in IN cord-302530-pp6bl941 484 28 magnitude magnitude NN cord-302530-pp6bl941 484 29 from from IN cord-302530-pp6bl941 484 30 −400 −400 NNP cord-302530-pp6bl941 484 31 J J NNP cord-302530-pp6bl941 484 32 / / SYM cord-302530-pp6bl941 484 33 mol mol NNP cord-302530-pp6bl941 484 34 / / SYM cord-302530-pp6bl941 484 35 K K NNP cord-302530-pp6bl941 484 36 to to IN cord-302530-pp6bl941 484 37 −240 −240 NNP cord-302530-pp6bl941 484 38 J J NNP cord-302530-pp6bl941 484 39 / / SYM cord-302530-pp6bl941 484 40 mol mol NNP cord-302530-pp6bl941 484 41 / / SYM cord-302530-pp6bl941 484 42 K. K. NNP cord-302530-pp6bl941 485 1 The the DT cord-302530-pp6bl941 485 2 conclusion conclusion NN cord-302530-pp6bl941 485 3 from from IN cord-302530-pp6bl941 485 4 Fig Fig NNP cord-302530-pp6bl941 485 5 . . . cord-302530-pp6bl941 486 1 5a 5a CD cord-302530-pp6bl941 486 2 and and CC cord-302530-pp6bl941 486 3 b b NN cord-302530-pp6bl941 486 4 is be VBZ cord-302530-pp6bl941 486 5 that that IN cord-302530-pp6bl941 486 6 smaller small JJR cord-302530-pp6bl941 486 7 viruses virus NNS cord-302530-pp6bl941 486 8 with with IN cord-302530-pp6bl941 486 9 less less RBR cord-302530-pp6bl941 486 10 negative negative JJ cord-302530-pp6bl941 486 11 ΔS ΔS NNP cord-302530-pp6bl941 486 12 a_immob a_immob NNP cord-302530-pp6bl941 486 13 bind bind VB cord-302530-pp6bl941 486 14 more more RBR cord-302530-pp6bl941 486 15 strongly strongly RB cord-302530-pp6bl941 486 16 at at IN cord-302530-pp6bl941 486 17 higher high JJR cord-302530-pp6bl941 486 18 temperatures temperature NNS cord-302530-pp6bl941 486 19 than than IN cord-302530-pp6bl941 486 20 larger large JJR cord-302530-pp6bl941 486 21 viruses virus NNS cord-302530-pp6bl941 486 22 . . . cord-302530-pp6bl941 487 1 Only only RB cord-302530-pp6bl941 487 2 with with IN cord-302530-pp6bl941 487 3 ΔS ΔS NNP cord-302530-pp6bl941 487 4 a_immob a_immob NNP cord-302530-pp6bl941 487 5 as as RB cord-302530-pp6bl941 487 6 high high JJ cord-302530-pp6bl941 487 7 as as IN cord-302530-pp6bl941 487 8 −240 −240 NNP cord-302530-pp6bl941 487 9 J J NNP cord-302530-pp6bl941 487 10 / / SYM cord-302530-pp6bl941 487 11 mol mol NNP cord-302530-pp6bl941 487 12 / / SYM cord-302530-pp6bl941 487 13 K K NNP cord-302530-pp6bl941 487 14 representing represent VBG cord-302530-pp6bl941 487 15 smaller small JJR cord-302530-pp6bl941 487 16 viruses virus NNS cord-302530-pp6bl941 487 17 do do VBP cord-302530-pp6bl941 487 18 more more JJR cord-302530-pp6bl941 487 19 than than IN cord-302530-pp6bl941 487 20 30 30 CD cord-302530-pp6bl941 487 21 % % NN cord-302530-pp6bl941 487 22 of of IN cord-302530-pp6bl941 487 23 the the DT cord-302530-pp6bl941 487 24 1000 1000 CD cord-302530-pp6bl941 487 25 cells cell NNS cord-302530-pp6bl941 487 26 have have VBP cord-302530-pp6bl941 487 27 bound bind VBN cord-302530-pp6bl941 487 28 virus virus NN cord-302530-pp6bl941 487 29 at at IN cord-302530-pp6bl941 487 30 the the DT cord-302530-pp6bl941 487 31 human human JJ cord-302530-pp6bl941 487 32 body body NN cord-302530-pp6bl941 487 33 temperature temperature NN cord-302530-pp6bl941 487 34 of of IN cord-302530-pp6bl941 487 35 37 37 CD cord-302530-pp6bl941 487 36 ° ° NN cord-302530-pp6bl941 487 37 C c NN cord-302530-pp6bl941 487 38 according accord VBG cord-302530-pp6bl941 487 39 to to IN cord-302530-pp6bl941 487 40 the the DT cord-302530-pp6bl941 487 41 model model NN cord-302530-pp6bl941 487 42 in in IN cord-302530-pp6bl941 487 43 Fig Fig NNP cord-302530-pp6bl941 487 44 . . . cord-302530-pp6bl941 488 1 5b 5b NN cord-302530-pp6bl941 488 2 . . . cord-302530-pp6bl941 489 1 This this DT cord-302530-pp6bl941 489 2 is be VBZ cord-302530-pp6bl941 489 3 shown show VBN cord-302530-pp6bl941 489 4 in in IN cord-302530-pp6bl941 489 5 Fig Fig NNP cord-302530-pp6bl941 489 6 . . . cord-302530-pp6bl941 490 1 5c 5c NNP cord-302530-pp6bl941 490 2 where where WRB cord-302530-pp6bl941 490 3 nearly nearly RB cord-302530-pp6bl941 490 4 all all PDT cord-302530-pp6bl941 490 5 the the DT cord-302530-pp6bl941 490 6 cells cell NNS cord-302530-pp6bl941 490 7 have have VBP cord-302530-pp6bl941 490 8 bound bind VBN cord-302530-pp6bl941 490 9 virus virus NN cord-302530-pp6bl941 490 10 at at IN cord-302530-pp6bl941 490 11 10 10 CD cord-302530-pp6bl941 490 12 ° ° NN cord-302530-pp6bl941 490 13 C c NN cord-302530-pp6bl941 490 14 irrespective irrespective RB cord-302530-pp6bl941 490 15 of of IN cord-302530-pp6bl941 490 16 ΔS ΔS NNP cord-302530-pp6bl941 490 17 a_immob a_immob NNP cord-302530-pp6bl941 490 18 while while IN cord-302530-pp6bl941 490 19 at at IN cord-302530-pp6bl941 490 20 higher high JJR cord-302530-pp6bl941 490 21 temperatures temperature NNS cord-302530-pp6bl941 490 22 fewer few JJR cord-302530-pp6bl941 490 23 cells cell NNS cord-302530-pp6bl941 490 24 have have VBP cord-302530-pp6bl941 490 25 bound bind VBN cord-302530-pp6bl941 490 26 virus virus NN cord-302530-pp6bl941 490 27 as as IN cord-302530-pp6bl941 490 28 ΔS ΔS NNP cord-302530-pp6bl941 490 29 a_immob a_immob NNP cord-302530-pp6bl941 490 30 becomes become VBZ cord-302530-pp6bl941 490 31 more more RBR cord-302530-pp6bl941 490 32 negative negative JJ cord-302530-pp6bl941 490 33 . . . cord-302530-pp6bl941 491 1 3.6 3.6 CD cord-302530-pp6bl941 491 2 . . . cord-302530-pp6bl941 492 1 Case case NN cord-302530-pp6bl941 492 2 study study NN cord-302530-pp6bl941 492 3 5 5 CD cord-302530-pp6bl941 492 4 : : : cord-302530-pp6bl941 493 1 HIV HIV NNP cord-302530-pp6bl941 493 2 attachment attachment NN cord-302530-pp6bl941 493 3 factors factor NNS cord-302530-pp6bl941 493 4 may may MD cord-302530-pp6bl941 493 5 partially partially RB cord-302530-pp6bl941 493 6 overcome overcome VB cord-302530-pp6bl941 493 7 the the DT cord-302530-pp6bl941 493 8 unfavourable unfavourable JJ cord-302530-pp6bl941 493 9 ΔS ΔS NNP cord-302530-pp6bl941 493 10 a_immob a_immob NNP cord-302530-pp6bl941 493 11 and and CC cord-302530-pp6bl941 493 12 enhance enhance VB cord-302530-pp6bl941 493 13 specific specific JJ cord-302530-pp6bl941 493 14 virus virus NN cord-302530-pp6bl941 493 15 binding bind VBG cord-302530-pp6bl941 493 16 through through IN cord-302530-pp6bl941 493 17 Env Env NNP cord-302530-pp6bl941 493 18 / / SYM cord-302530-pp6bl941 493 19 CD4 CD4 NNP cord-302530-pp6bl941 493 20 interactions interaction NNS cord-302530-pp6bl941 493 21 at at IN cord-302530-pp6bl941 493 22 human human JJ cord-302530-pp6bl941 493 23 body body NN cord-302530-pp6bl941 493 24 temperature temperature NN cord-302530-pp6bl941 493 25 thus thus RB cord-302530-pp6bl941 493 26 increasing increase VBG cord-302530-pp6bl941 493 27 ΔS ΔS NNP cord-302530-pp6bl941 493 28 a_specific a_specific NNP cord-302530-pp6bl941 493 29 for for IN cord-302530-pp6bl941 493 30 specific specific JJ cord-302530-pp6bl941 493 31 Env env NN cord-302530-pp6bl941 493 32 : : : cord-302530-pp6bl941 494 1 CD4 CD4 NNP cord-302530-pp6bl941 494 2 binding bind VBG cord-302530-pp6bl941 494 3 ( ( -LRB- cord-302530-pp6bl941 494 4 as as IN cord-302530-pp6bl941 494 5 ΔS ΔS NNP cord-302530-pp6bl941 494 6 a_immob a_immob NNP cord-302530-pp6bl941 494 7 in in IN cord-302530-pp6bl941 494 8 Eq Eq NNP cord-302530-pp6bl941 494 9 . . . cord-302530-pp6bl941 495 1 ( ( -LRB- cord-302530-pp6bl941 495 2 11 11 CD cord-302530-pp6bl941 495 3 ) ) -RRB- cord-302530-pp6bl941 495 4 ) ) -RRB- cord-302530-pp6bl941 495 5 from from IN cord-302530-pp6bl941 495 6 −400 −400 NNP cord-302530-pp6bl941 495 7 J J NNP cord-302530-pp6bl941 495 8 / / SYM cord-302530-pp6bl941 495 9 mol mol NNP cord-302530-pp6bl941 495 10 / / SYM cord-302530-pp6bl941 495 11 K K NNP cord-302530-pp6bl941 495 12 to to IN cord-302530-pp6bl941 495 13 −240 −240 NNP cord-302530-pp6bl941 495 14 J J NNP cord-302530-pp6bl941 495 15 / / SYM cord-302530-pp6bl941 495 16 mol mol NNP cord-302530-pp6bl941 495 17 / / SYM cord-302530-pp6bl941 495 18 K. K. NNP cord-302530-pp6bl941 495 19 Fig Fig NNP cord-302530-pp6bl941 495 20 . . . cord-302530-pp6bl941 496 1 5b 5b NN cord-302530-pp6bl941 496 2 shows show VBZ cord-302530-pp6bl941 496 3 that that IN cord-302530-pp6bl941 496 4 the the DT cord-302530-pp6bl941 496 5 number number NN cord-302530-pp6bl941 496 6 of of IN cord-302530-pp6bl941 496 7 CD4 CD4 NNP cord-302530-pp6bl941 496 8 + + CC cord-302530-pp6bl941 496 9 T T NNP cord-302530-pp6bl941 496 10 cells cell NNS cord-302530-pp6bl941 496 11 in in IN cord-302530-pp6bl941 496 12 a a DT cord-302530-pp6bl941 496 13 1 1 CD cord-302530-pp6bl941 496 14 mm mm CD cord-302530-pp6bl941 496 15 3 3 CD cord-302530-pp6bl941 496 16 vol vol NN cord-302530-pp6bl941 496 17 of of IN cord-302530-pp6bl941 496 18 blood blood NN cord-302530-pp6bl941 496 19 with with IN cord-302530-pp6bl941 496 20 bound bind VBN cord-302530-pp6bl941 496 21 HIV HIV NNP cord-302530-pp6bl941 496 22 falls fall VBZ cord-302530-pp6bl941 496 23 from from IN cord-302530-pp6bl941 496 24 1000 1000 CD cord-302530-pp6bl941 496 25 to to IN cord-302530-pp6bl941 496 26 < < XX cord-302530-pp6bl941 496 27 1 1 CD cord-302530-pp6bl941 496 28 over over IN cord-302530-pp6bl941 496 29 a a DT cord-302530-pp6bl941 496 30 temperature temperature NN cord-302530-pp6bl941 496 31 range range NN cord-302530-pp6bl941 496 32 of~10 of~10 NNP cord-302530-pp6bl941 496 33 ° ° NN cord-302530-pp6bl941 496 34 C C NNP cord-302530-pp6bl941 496 35 . . . cord-302530-pp6bl941 497 1 The the DT cord-302530-pp6bl941 497 2 temperature temperature NN cord-302530-pp6bl941 497 3 at at IN cord-302530-pp6bl941 497 4 which which WDT cord-302530-pp6bl941 497 5 fewer few JJR cord-302530-pp6bl941 497 6 than than IN cord-302530-pp6bl941 497 7 half half PDT cord-302530-pp6bl941 497 8 the the DT cord-302530-pp6bl941 497 9 T t NN cord-302530-pp6bl941 497 10 cells cell NNS cord-302530-pp6bl941 497 11 in in IN cord-302530-pp6bl941 497 12 the the DT cord-302530-pp6bl941 497 13 1 1 CD cord-302530-pp6bl941 497 14 mm mm CD cord-302530-pp6bl941 497 15 3 3 CD cord-302530-pp6bl941 497 16 vol vol NN cord-302530-pp6bl941 497 17 of of IN cord-302530-pp6bl941 497 18 blood blood NN cord-302530-pp6bl941 497 19 have have VBP cord-302530-pp6bl941 497 20 bound bind VBN cord-302530-pp6bl941 497 21 HIV HIV NNP cord-302530-pp6bl941 497 22 virus virus NN cord-302530-pp6bl941 497 23 increases increase VBZ cord-302530-pp6bl941 497 24 with with IN cord-302530-pp6bl941 497 25 increasing increase VBG cord-302530-pp6bl941 497 26 ΔS ΔS NNP cord-302530-pp6bl941 497 27 a_specific a_specific NNP cord-302530-pp6bl941 497 28 from from IN cord-302530-pp6bl941 497 29 12.5 12.5 CD cord-302530-pp6bl941 497 30 ° ° NN cord-302530-pp6bl941 497 31 C c NN cord-302530-pp6bl941 497 32 for for IN cord-302530-pp6bl941 497 33 ΔS ΔS NNP cord-302530-pp6bl941 497 34 a_specific a_specific NNP cord-302530-pp6bl941 497 35 = = NFP cord-302530-pp6bl941 498 1 −400 −400 NNP cord-302530-pp6bl941 498 2 J J NNP cord-302530-pp6bl941 498 3 / / SYM cord-302530-pp6bl941 498 4 mol mol NNP cord-302530-pp6bl941 498 5 / / SYM cord-302530-pp6bl941 498 6 K K NNP cord-302530-pp6bl941 498 7 to to IN cord-302530-pp6bl941 498 8 36.5 36.5 CD cord-302530-pp6bl941 498 9 ° ° NN cord-302530-pp6bl941 498 10 C c NN cord-302530-pp6bl941 498 11 for for IN cord-302530-pp6bl941 499 1 ΔS ΔS NNP cord-302530-pp6bl941 499 2 a_specific a_specific NNP cord-302530-pp6bl941 499 3 = = NFP cord-302530-pp6bl941 500 1 −240 −240 NNP cord-302530-pp6bl941 500 2 J J NNP cord-302530-pp6bl941 500 3 / / SYM cord-302530-pp6bl941 500 4 mol mol NNP cord-302530-pp6bl941 500 5 / / SYM cord-302530-pp6bl941 500 6 K K NNP cord-302530-pp6bl941 501 1 ( ( -LRB- cord-302530-pp6bl941 501 2 Fig Fig NNP cord-302530-pp6bl941 501 3 . . . cord-302530-pp6bl941 501 4 5b 5b CD cord-302530-pp6bl941 501 5 ) ) -RRB- cord-302530-pp6bl941 501 6 . . . cord-302530-pp6bl941 502 1 Indeed indeed RB cord-302530-pp6bl941 502 2 once once IN cord-302530-pp6bl941 502 3 the the DT cord-302530-pp6bl941 502 4 ΔS ΔS NNP cord-302530-pp6bl941 502 5 a_specific a_specific NNP cord-302530-pp6bl941 502 6 is be VBZ cord-302530-pp6bl941 502 7 > > XX cord-302530-pp6bl941 503 1 −200 −200 NNP cord-302530-pp6bl941 503 2 J J NNP cord-302530-pp6bl941 503 3 / / SYM cord-302530-pp6bl941 503 4 mol mol NNP cord-302530-pp6bl941 503 5 / / SYM cord-302530-pp6bl941 503 6 K K NNP cord-302530-pp6bl941 503 7 , , , cord-302530-pp6bl941 503 8 98 98 CD cord-302530-pp6bl941 503 9 % % NN cord-302530-pp6bl941 503 10 of of IN cord-302530-pp6bl941 503 11 the the DT cord-302530-pp6bl941 503 12 1000 1000 CD cord-302530-pp6bl941 503 13 T t NN cord-302530-pp6bl941 503 14 cells cell NNS cord-302530-pp6bl941 503 15 have have VBP cord-302530-pp6bl941 503 16 bound bind VBN cord-302530-pp6bl941 503 17 HIV HIV NNP cord-302530-pp6bl941 503 18 at at IN cord-302530-pp6bl941 503 19 37 37 CD cord-302530-pp6bl941 503 20 ° ° NN cord-302530-pp6bl941 503 21 C c NN cord-302530-pp6bl941 503 22 ( ( -LRB- cord-302530-pp6bl941 503 23 not not RB cord-302530-pp6bl941 503 24 shown show VBN cord-302530-pp6bl941 503 25 ) ) -RRB- cord-302530-pp6bl941 503 26 . . . cord-302530-pp6bl941 504 1 With with IN cord-302530-pp6bl941 504 2 ΔS ΔS NNP cord-302530-pp6bl941 504 3 a_specific a_specific NNP cord-302530-pp6bl941 504 4 < < XX cord-302530-pp6bl941 504 5 −285 −285 NNP cord-302530-pp6bl941 504 6 J J NNP cord-302530-pp6bl941 504 7 / / SYM cord-302530-pp6bl941 504 8 mol mol NNP cord-302530-pp6bl941 504 9 / / SYM cord-302530-pp6bl941 504 10 K K NNP cord-302530-pp6bl941 504 11 virus virus NN cord-302530-pp6bl941 504 12 is be VBZ cord-302530-pp6bl941 504 13 not not RB cord-302530-pp6bl941 504 14 specifically specifically RB cord-302530-pp6bl941 504 15 bound bind VBN cord-302530-pp6bl941 504 16 to to IN cord-302530-pp6bl941 504 17 any any DT cord-302530-pp6bl941 504 18 of of IN cord-302530-pp6bl941 504 19 the the DT cord-302530-pp6bl941 504 20 1000 1000 CD cord-302530-pp6bl941 504 21 T t NN cord-302530-pp6bl941 504 22 cells cell NNS cord-302530-pp6bl941 504 23 at at IN cord-302530-pp6bl941 504 24 temperatures temperature NNS cord-302530-pp6bl941 504 25 above above IN cord-302530-pp6bl941 504 26 37 37 CD cord-302530-pp6bl941 504 27 ° ° NN cord-302530-pp6bl941 504 28 C c NN cord-302530-pp6bl941 504 29 . . . cord-302530-pp6bl941 505 1 It -PRON- PRP cord-302530-pp6bl941 505 2 is be VBZ cord-302530-pp6bl941 505 3 concluded conclude VBN cord-302530-pp6bl941 505 4 that that IN cord-302530-pp6bl941 505 5 the the DT cord-302530-pp6bl941 505 6 effect effect NN cord-302530-pp6bl941 505 7 of of IN cord-302530-pp6bl941 505 8 making make VBG cord-302530-pp6bl941 505 9 ΔS ΔS NNP cord-302530-pp6bl941 505 10 a_immob a_immob NNP cord-302530-pp6bl941 505 11 less less RBR cord-302530-pp6bl941 505 12 unfavourable unfavourable JJ cord-302530-pp6bl941 505 13 through through IN cord-302530-pp6bl941 505 14 prior prior JJ cord-302530-pp6bl941 505 15 non non JJ cord-302530-pp6bl941 505 16 - - JJ cord-302530-pp6bl941 505 17 specific specific JJ cord-302530-pp6bl941 505 18 binding binding NN cord-302530-pp6bl941 505 19 taking take VBG cord-302530-pp6bl941 505 20 some some DT cord-302530-pp6bl941 505 21 of of IN cord-302530-pp6bl941 505 22 the the DT cord-302530-pp6bl941 505 23 entropy entropy NN cord-302530-pp6bl941 505 24 loss loss NN cord-302530-pp6bl941 505 25 enhances enhance VBZ cord-302530-pp6bl941 505 26 subsequent subsequent JJ cord-302530-pp6bl941 505 27 specific specific JJ cord-302530-pp6bl941 505 28 binding binding NN cord-302530-pp6bl941 505 29 of of IN cord-302530-pp6bl941 505 30 HIV HIV NNP cord-302530-pp6bl941 505 31 through through IN cord-302530-pp6bl941 505 32 Env Env NNP cord-302530-pp6bl941 505 33 : : : cord-302530-pp6bl941 506 1 CD4 CD4 NNP cord-302530-pp6bl941 506 2 interactions interaction NNS cord-302530-pp6bl941 506 3 at at IN cord-302530-pp6bl941 506 4 higher high JJR cord-302530-pp6bl941 506 5 temperatures temperature NNS cord-302530-pp6bl941 506 6 . . . cord-302530-pp6bl941 507 1 Fig Fig NNP cord-302530-pp6bl941 507 2 . . . cord-302530-pp6bl941 508 1 5c 5c NNP cord-302530-pp6bl941 508 2 shows show VBZ cord-302530-pp6bl941 508 3 that that IN cord-302530-pp6bl941 508 4 at at IN cord-302530-pp6bl941 508 5 37 37 CD cord-302530-pp6bl941 508 6 ° ° NN cord-302530-pp6bl941 508 7 C c NN cord-302530-pp6bl941 508 8 increasing increase VBG cord-302530-pp6bl941 508 9 ΔS ΔS NNP cord-302530-pp6bl941 508 10 a_specific a_specific NNP cord-302530-pp6bl941 508 11 from from IN cord-302530-pp6bl941 508 12 −400 −400 NNP cord-302530-pp6bl941 508 13 to to IN cord-302530-pp6bl941 508 14 −240 −240 NNP cord-302530-pp6bl941 508 15 J J NNP cord-302530-pp6bl941 508 16 / / SYM cord-302530-pp6bl941 508 17 mol mol NNP cord-302530-pp6bl941 508 18 / / SYM cord-302530-pp6bl941 508 19 K K NNP cord-302530-pp6bl941 508 20 increases increase VBZ cord-302530-pp6bl941 508 21 the the DT cord-302530-pp6bl941 508 22 number number NN cord-302530-pp6bl941 508 23 of of IN cord-302530-pp6bl941 508 24 CD4 CD4 NNP cord-302530-pp6bl941 508 25 + + CC cord-302530-pp6bl941 508 26 T T NNP cord-302530-pp6bl941 508 27 cells cell NNS cord-302530-pp6bl941 508 28 with with IN cord-302530-pp6bl941 508 29 HIV HIV NNP cord-302530-pp6bl941 508 30 bound bind VBN cord-302530-pp6bl941 508 31 through through IN cord-302530-pp6bl941 508 32 specific specific JJ cord-302530-pp6bl941 508 33 Env Env NNP cord-302530-pp6bl941 508 34 / / SYM cord-302530-pp6bl941 508 35 CD4 CD4 NNP cord-302530-pp6bl941 508 36 interactions interaction NNS cord-302530-pp6bl941 508 37 in in IN cord-302530-pp6bl941 508 38 a a DT cord-302530-pp6bl941 508 39 1 1 CD cord-302530-pp6bl941 508 40 mm mm CD cord-302530-pp6bl941 508 41 3 3 CD cord-302530-pp6bl941 508 42 vol vol NN cord-302530-pp6bl941 508 43 of of IN cord-302530-pp6bl941 508 44 blood blood NN cord-302530-pp6bl941 508 45 from from IN cord-302530-pp6bl941 508 46 2 2 CD cord-302530-pp6bl941 508 47 × × CD cord-302530-pp6bl941 508 48 10 10 CD cord-302530-pp6bl941 508 49 −6 −6 NNS cord-302530-pp6bl941 508 50 to to IN cord-302530-pp6bl941 508 51 307 307 CD cord-302530-pp6bl941 508 52 . . . cord-302530-pp6bl941 509 1 It -PRON- PRP cord-302530-pp6bl941 509 2 should should MD cord-302530-pp6bl941 509 3 be be VB cord-302530-pp6bl941 509 4 noted note VBN cord-302530-pp6bl941 509 5 that that IN cord-302530-pp6bl941 509 6 2 2 CD cord-302530-pp6bl941 509 7 × × CD cord-302530-pp6bl941 509 8 10 10 CD cord-302530-pp6bl941 509 9 −6 −6 NNP cord-302530-pp6bl941 509 10 cells cell NNS cord-302530-pp6bl941 509 11 in in IN cord-302530-pp6bl941 509 12 1 1 CD cord-302530-pp6bl941 509 13 mm mm CD cord-302530-pp6bl941 509 14 3 3 CD cord-302530-pp6bl941 509 15 is be VBZ cord-302530-pp6bl941 509 16 equivalent equivalent JJ cord-302530-pp6bl941 509 17 to to IN cord-302530-pp6bl941 509 18 1 1 CD cord-302530-pp6bl941 509 19 cell cell NN cord-302530-pp6bl941 509 20 in in IN cord-302530-pp6bl941 509 21 500 500 CD cord-302530-pp6bl941 509 22 cm cm NNS cord-302530-pp6bl941 509 23 3 3 CD cord-302530-pp6bl941 509 24 of of IN cord-302530-pp6bl941 509 25 blood blood NN cord-302530-pp6bl941 509 26 . . . cord-302530-pp6bl941 510 1 3.7 3.7 CD cord-302530-pp6bl941 510 2 . . . cord-302530-pp6bl941 511 1 Case case NN cord-302530-pp6bl941 511 2 study study NN cord-302530-pp6bl941 511 3 6 6 CD cord-302530-pp6bl941 511 4 : : : cord-302530-pp6bl941 512 1 Increasing increase VBG cord-302530-pp6bl941 512 2 the the DT cord-302530-pp6bl941 512 3 number number NN cord-302530-pp6bl941 512 4 , , , cord-302530-pp6bl941 512 5 n n NN cord-302530-pp6bl941 512 6 , , , cord-302530-pp6bl941 512 7 of of IN cord-302530-pp6bl941 512 8 GP GP NNP cord-302530-pp6bl941 512 9 / / SYM cord-302530-pp6bl941 512 10 Cr cr NN cord-302530-pp6bl941 512 11 contacts contact NNS cord-302530-pp6bl941 512 12 with with IN cord-302530-pp6bl941 512 13 temperature temperature NN cord-302530-pp6bl941 512 14 to to TO cord-302530-pp6bl941 512 15 reproduce reproduce VB cord-302530-pp6bl941 512 16 the the DT cord-302530-pp6bl941 512 17 data datum NNS cord-302530-pp6bl941 512 18 of of IN cord-302530-pp6bl941 512 19 Frey Frey NNP cord-302530-pp6bl941 512 20 et et NNP cord-302530-pp6bl941 512 21 al al NNP cord-302530-pp6bl941 512 22 . . . cord-302530-pp6bl941 513 1 ( ( -LRB- cord-302530-pp6bl941 513 2 1995 1995 CD cord-302530-pp6bl941 513 3 ) ) -RRB- cord-302530-pp6bl941 513 4 _SP cord-302530-pp6bl941 513 5 Cells Cells NNP cord-302530-pp6bl941 513 6 expressing express VBG cord-302530-pp6bl941 513 7 HIV HIV NNP cord-302530-pp6bl941 513 8 Env Env NNP cord-302530-pp6bl941 513 9 on on IN cord-302530-pp6bl941 513 10 their -PRON- PRP$ cord-302530-pp6bl941 513 11 surface surface NN cord-302530-pp6bl941 513 12 can can MD cord-302530-pp6bl941 513 13 bind bind VB cord-302530-pp6bl941 513 14 and and CC cord-302530-pp6bl941 513 15 fuse fuse VB cord-302530-pp6bl941 513 16 with with IN cord-302530-pp6bl941 513 17 cells cell NNS cord-302530-pp6bl941 513 18 expressing express VBG cord-302530-pp6bl941 513 19 CD4 CD4 NNP cord-302530-pp6bl941 513 20 Cr Cr NNP cord-302530-pp6bl941 513 21 ( ( -LRB- cord-302530-pp6bl941 513 22 Frey Frey NNP cord-302530-pp6bl941 513 23 et et NNP cord-302530-pp6bl941 513 24 al al NNP cord-302530-pp6bl941 513 25 . . NNP cord-302530-pp6bl941 513 26 , , , cord-302530-pp6bl941 513 27 1995 1995 CD cord-302530-pp6bl941 513 28 ) ) -RRB- cord-302530-pp6bl941 513 29 . . . cord-302530-pp6bl941 514 1 Frey Frey NNP cord-302530-pp6bl941 514 2 et et NNP cord-302530-pp6bl941 514 3 al al NNP cord-302530-pp6bl941 514 4 . . . cord-302530-pp6bl941 515 1 ( ( -LRB- cord-302530-pp6bl941 515 2 1995 1995 CD cord-302530-pp6bl941 515 3 ) ) -RRB- cord-302530-pp6bl941 515 4 reported report VBD cord-302530-pp6bl941 515 5 a a DT cord-302530-pp6bl941 515 6 three three CD cord-302530-pp6bl941 515 7 to to TO cord-302530-pp6bl941 515 8 four four CD cord-302530-pp6bl941 515 9 fold fold JJ cord-302530-pp6bl941 515 10 increase increase NN cord-302530-pp6bl941 515 11 in in IN cord-302530-pp6bl941 515 12 cell cell NN cord-302530-pp6bl941 515 13 binding bind VBG cord-302530-pp6bl941 515 14 at at IN cord-302530-pp6bl941 515 15 temperatures temperature NNS cord-302530-pp6bl941 515 16 above above IN cord-302530-pp6bl941 515 17 25 25 CD cord-302530-pp6bl941 515 18 ° ° NN cord-302530-pp6bl941 515 19 C c NN cord-302530-pp6bl941 515 20 with with IN cord-302530-pp6bl941 515 21 a a DT cord-302530-pp6bl941 515 22 substantial substantial JJ cord-302530-pp6bl941 515 23 decrease decrease NN cord-302530-pp6bl941 515 24 in in IN cord-302530-pp6bl941 515 25 binding bind VBG cord-302530-pp6bl941 515 26 at at IN cord-302530-pp6bl941 515 27 temperatures temperature NNS cord-302530-pp6bl941 515 28 above above IN cord-302530-pp6bl941 515 29 37 37 CD cord-302530-pp6bl941 515 30 ° ° NN cord-302530-pp6bl941 515 31 C c NN cord-302530-pp6bl941 515 32 ( ( -LRB- cord-302530-pp6bl941 515 33 Fig Fig NNP cord-302530-pp6bl941 515 34 . . . cord-302530-pp6bl941 515 35 6 6 CD cord-302530-pp6bl941 515 36 ) ) -RRB- cord-302530-pp6bl941 515 37 , , , cord-302530-pp6bl941 515 38 the the DT cord-302530-pp6bl941 515 39 latter latter JJ cord-302530-pp6bl941 515 40 being be VBG cord-302530-pp6bl941 515 41 predicted predict VBN cord-302530-pp6bl941 515 42 by by IN cord-302530-pp6bl941 515 43 the the DT cord-302530-pp6bl941 515 44 thermodynamic thermodynamic JJ cord-302530-pp6bl941 515 45 model model NN cord-302530-pp6bl941 515 46 in in IN cord-302530-pp6bl941 515 47 Fig Fig NNP cord-302530-pp6bl941 515 48 . . . cord-302530-pp6bl941 516 1 5b 5b NN cord-302530-pp6bl941 516 2 . . . cord-302530-pp6bl941 517 1 Frey Frey NNP cord-302530-pp6bl941 517 2 et et NNP cord-302530-pp6bl941 517 3 al al NNP cord-302530-pp6bl941 517 4 . . . cord-302530-pp6bl941 518 1 ( ( -LRB- cord-302530-pp6bl941 518 2 1995 1995 CD cord-302530-pp6bl941 518 3 ) ) -RRB- cord-302530-pp6bl941 518 4 attribute attribute VB cord-302530-pp6bl941 518 5 the the DT cord-302530-pp6bl941 518 6 increase increase NN cord-302530-pp6bl941 518 7 at at IN cord-302530-pp6bl941 518 8 25 25 CD cord-302530-pp6bl941 518 9 ° ° NN cord-302530-pp6bl941 518 10 C c NN cord-302530-pp6bl941 518 11 to to IN cord-302530-pp6bl941 518 12 the the DT cord-302530-pp6bl941 518 13 additional additional JJ cord-302530-pp6bl941 518 14 adhesion adhesion NN cord-302530-pp6bl941 518 15 molecules molecule NNS cord-302530-pp6bl941 518 16 which which WDT cord-302530-pp6bl941 518 17 are be VBP cord-302530-pp6bl941 518 18 brought bring VBN cord-302530-pp6bl941 518 19 into into IN cord-302530-pp6bl941 518 20 contact contact NN cord-302530-pp6bl941 518 21 to to TO cord-302530-pp6bl941 518 22 increase increase VB cord-302530-pp6bl941 518 23 the the DT cord-302530-pp6bl941 518 24 avidity avidity NN cord-302530-pp6bl941 518 25 of of IN cord-302530-pp6bl941 518 26 binding bind VBG cord-302530-pp6bl941 518 27 at at IN cord-302530-pp6bl941 518 28 higher high JJR cord-302530-pp6bl941 518 29 temperatures temperature NNS cord-302530-pp6bl941 518 30 . . . cord-302530-pp6bl941 519 1 The the DT cord-302530-pp6bl941 519 2 thermodynamic thermodynamic JJ cord-302530-pp6bl941 519 3 model model NN cord-302530-pp6bl941 519 4 for for IN cord-302530-pp6bl941 519 5 HIV HIV NNP cord-302530-pp6bl941 519 6 binding bind VBG cord-302530-pp6bl941 519 7 with with IN cord-302530-pp6bl941 519 8 ΔS ΔS NNP cord-302530-pp6bl941 519 9 a_immob a_immob NNP cord-302530-pp6bl941 519 10 of of IN cord-302530-pp6bl941 519 11 −206 −206 NNP cord-302530-pp6bl941 519 12 J J NNP cord-302530-pp6bl941 519 13 / / SYM cord-302530-pp6bl941 519 14 mol mol NNP cord-302530-pp6bl941 519 15 / / SYM cord-302530-pp6bl941 519 16 K K NNP cord-302530-pp6bl941 519 17 reproduces reproduce VBZ cord-302530-pp6bl941 519 18 the the DT cord-302530-pp6bl941 519 19 increase increase NN cord-302530-pp6bl941 519 20 in in IN cord-302530-pp6bl941 519 21 predicted predict VBN cord-302530-pp6bl941 519 22 C.V C.V NNP cord-302530-pp6bl941 519 23 T T NNP cord-302530-pp6bl941 519 24 in in IN cord-302530-pp6bl941 519 25 Fig Fig NNP cord-302530-pp6bl941 519 26 . . . cord-302530-pp6bl941 520 1 6a 6a LS cord-302530-pp6bl941 520 2 by by IN cord-302530-pp6bl941 520 3 increasing increase VBG cord-302530-pp6bl941 520 4 n n NN cord-302530-pp6bl941 520 5 from from IN cord-302530-pp6bl941 520 6 1 1 CD cord-302530-pp6bl941 520 7 to to IN cord-302530-pp6bl941 520 8 3 3 CD cord-302530-pp6bl941 520 9 over over IN cord-302530-pp6bl941 520 10 the the DT cord-302530-pp6bl941 520 11 temperature temperature NN cord-302530-pp6bl941 520 12 range range NN cord-302530-pp6bl941 520 13 25 25 CD cord-302530-pp6bl941 520 14 ° ° NN cord-302530-pp6bl941 520 15 C c NN cord-302530-pp6bl941 520 16 and and CC cord-302530-pp6bl941 520 17 27 27 CD cord-302530-pp6bl941 520 18 ° ° NN cord-302530-pp6bl941 520 19 C c NN cord-302530-pp6bl941 520 20 to to TO cord-302530-pp6bl941 520 21 reflect reflect VB cord-302530-pp6bl941 520 22 the the DT cord-302530-pp6bl941 520 23 effect effect NN cord-302530-pp6bl941 520 24 of of IN cord-302530-pp6bl941 520 25 temperature temperature NN cord-302530-pp6bl941 520 26 facilitating facilitate VBG cord-302530-pp6bl941 520 27 multiple multiple JJ cord-302530-pp6bl941 520 28 HIV HIV NNP cord-302530-pp6bl941 520 29 adhesion adhesion NN cord-302530-pp6bl941 520 30 / / SYM cord-302530-pp6bl941 520 31 binding bind VBG cord-302530-pp6bl941 520 32 sites site NNS cord-302530-pp6bl941 520 33 due due JJ cord-302530-pp6bl941 520 34 to to IN cord-302530-pp6bl941 520 35 increased increase VBN cord-302530-pp6bl941 520 36 membrane membrane NN cord-302530-pp6bl941 520 37 fluidity fluidity NN cord-302530-pp6bl941 520 38 ( ( -LRB- cord-302530-pp6bl941 520 39 Frey Frey NNP cord-302530-pp6bl941 520 40 et et NNP cord-302530-pp6bl941 520 41 al al NNP cord-302530-pp6bl941 520 42 . . NNP cord-302530-pp6bl941 520 43 , , , cord-302530-pp6bl941 520 44 1995 1995 CD cord-302530-pp6bl941 520 45 ; ; : cord-302530-pp6bl941 520 46 Harada Harada NNP cord-302530-pp6bl941 520 47 et et NNP cord-302530-pp6bl941 520 48 al al NNP cord-302530-pp6bl941 520 49 . . NNP cord-302530-pp6bl941 520 50 , , , cord-302530-pp6bl941 520 51 2004 2004 CD cord-302530-pp6bl941 520 52 ) ) -RRB- cord-302530-pp6bl941 520 53 . . . cord-302530-pp6bl941 521 1 Increasing increase VBG cord-302530-pp6bl941 521 2 n n CC cord-302530-pp6bl941 521 3 from from IN cord-302530-pp6bl941 521 4 1 1 CD cord-302530-pp6bl941 521 5 to to IN cord-302530-pp6bl941 521 6 9 9 CD cord-302530-pp6bl941 521 7 over over IN cord-302530-pp6bl941 521 8 the the DT cord-302530-pp6bl941 521 9 temperature temperature NN cord-302530-pp6bl941 521 10 range range NN cord-302530-pp6bl941 521 11 19 19 CD cord-302530-pp6bl941 521 12 ° ° NN cord-302530-pp6bl941 521 13 C c NN cord-302530-pp6bl941 521 14 and and CC cord-302530-pp6bl941 521 15 27 27 CD cord-302530-pp6bl941 521 16 ° ° NNS cord-302530-pp6bl941 522 1 C C NNP cord-302530-pp6bl941 522 2 gives give VBZ cord-302530-pp6bl941 522 3 a a DT cord-302530-pp6bl941 522 4 sharp sharp JJ cord-302530-pp6bl941 522 5 increase increase NN cord-302530-pp6bl941 522 6 in in IN cord-302530-pp6bl941 522 7 C.V C.V NNP cord-302530-pp6bl941 522 8 T T NNP cord-302530-pp6bl941 522 9 at at IN cord-302530-pp6bl941 522 10 26 26 CD cord-302530-pp6bl941 522 11 ° ° NN cord-302530-pp6bl941 522 12 C c NN cord-302530-pp6bl941 522 13 ( ( -LRB- cord-302530-pp6bl941 522 14 Fig Fig NNP cord-302530-pp6bl941 522 15 . . . cord-302530-pp6bl941 522 16 6b 6b CD cord-302530-pp6bl941 522 17 ) ) -RRB- cord-302530-pp6bl941 522 18 with with IN cord-302530-pp6bl941 522 19 ΔS ΔS NNP cord-302530-pp6bl941 522 20 a_immob a_immob NNP cord-302530-pp6bl941 522 21 of of IN cord-302530-pp6bl941 522 22 −1110 −1110 NNP cord-302530-pp6bl941 522 23 J J NNP cord-302530-pp6bl941 522 24 / / SYM cord-302530-pp6bl941 522 25 mol mol NNP cord-302530-pp6bl941 522 26 / / SYM cord-302530-pp6bl941 522 27 K. K. NNP cord-302530-pp6bl941 523 1 The the DT cord-302530-pp6bl941 523 2 subsequent subsequent JJ cord-302530-pp6bl941 523 3 sharp sharp JJ cord-302530-pp6bl941 523 4 fall fall NN cord-302530-pp6bl941 523 5 in in IN cord-302530-pp6bl941 523 6 C.V C.V NNP cord-302530-pp6bl941 523 7 T T NNP cord-302530-pp6bl941 523 8 at at IN cord-302530-pp6bl941 523 9 temperatures temperature NNS cord-302530-pp6bl941 523 10 above above IN cord-302530-pp6bl941 523 11 37 37 CD cord-302530-pp6bl941 523 12 ° ° NN cord-302530-pp6bl941 524 1 C C NNP cord-302530-pp6bl941 524 2 is be VBZ cord-302530-pp6bl941 524 3 due due JJ cord-302530-pp6bl941 524 4 to to IN cord-302530-pp6bl941 524 5 the the DT cord-302530-pp6bl941 524 6 large large JJ cord-302530-pp6bl941 524 7 negative negative JJ cord-302530-pp6bl941 524 8 magnitude magnitude NN cord-302530-pp6bl941 524 9 of of IN cord-302530-pp6bl941 524 10 ΔS ΔS NNP cord-302530-pp6bl941 524 11 a_immob a_immob NNP cord-302530-pp6bl941 524 12 ( ( -LRB- cord-302530-pp6bl941 524 13 −206 −206 UH cord-302530-pp6bl941 524 14 J J NNP cord-302530-pp6bl941 524 15 / / SYM cord-302530-pp6bl941 524 16 mol mol NNP cord-302530-pp6bl941 524 17 / / SYM cord-302530-pp6bl941 524 18 K K NNP cord-302530-pp6bl941 524 19 in in IN cord-302530-pp6bl941 524 20 Fig Fig NNP cord-302530-pp6bl941 524 21 . . . cord-302530-pp6bl941 525 1 6a 6a NNP cord-302530-pp6bl941 525 2 and and CC cord-302530-pp6bl941 525 3 -1110 -1110 VBZ cord-302530-pp6bl941 525 4 J J NNP cord-302530-pp6bl941 525 5 / / SYM cord-302530-pp6bl941 525 6 mol mol NNP cord-302530-pp6bl941 525 7 / / SYM cord-302530-pp6bl941 525 8 K K NNP cord-302530-pp6bl941 525 9 in in IN cord-302530-pp6bl941 525 10 Fig Fig NNP cord-302530-pp6bl941 525 11 . . . cord-302530-pp6bl941 526 1 6b 6b LS cord-302530-pp6bl941 526 2 ) ) -RRB- cord-302530-pp6bl941 526 3 relative relative NN cord-302530-pp6bl941 526 4 to to IN cord-302530-pp6bl941 527 1 n n LS cord-302530-pp6bl941 527 2 such such JJ cord-302530-pp6bl941 527 3 that that IN cord-302530-pp6bl941 527 4 the the DT cord-302530-pp6bl941 527 5 diminished diminished JJ cord-302530-pp6bl941 527 6 GP GP NNP cord-302530-pp6bl941 527 7 / / SYM cord-302530-pp6bl941 527 8 Cr cr NN cord-302530-pp6bl941 527 9 affinity affinity NN cord-302530-pp6bl941 527 10 at at IN cord-302530-pp6bl941 527 11 higher high JJR cord-302530-pp6bl941 527 12 temperatures temperature NNS cord-302530-pp6bl941 527 13 is be VBZ cord-302530-pp6bl941 527 14 not not RB cord-302530-pp6bl941 527 15 sufficient sufficient JJ cord-302530-pp6bl941 527 16 to to TO cord-302530-pp6bl941 527 17 maintain maintain VB cord-302530-pp6bl941 527 18 binding binding NN cord-302530-pp6bl941 527 19 even even RB cord-302530-pp6bl941 527 20 with with IN cord-302530-pp6bl941 527 21 n n NN cord-302530-pp6bl941 527 22 = = NN cord-302530-pp6bl941 527 23 9 9 CD cord-302530-pp6bl941 527 24 GP GP NNP cord-302530-pp6bl941 527 25 / / SYM cord-302530-pp6bl941 527 26 Cr cr NN cord-302530-pp6bl941 527 27 interactions interaction NNS cord-302530-pp6bl941 527 28 in in IN cord-302530-pp6bl941 527 29 Fig Fig NNP cord-302530-pp6bl941 527 30 . . . cord-302530-pp6bl941 528 1 6b 6b CD cord-302530-pp6bl941 528 2 . . . cord-302530-pp6bl941 529 1 The the DT cord-302530-pp6bl941 529 2 decrease decrease NN cord-302530-pp6bl941 529 3 in in IN cord-302530-pp6bl941 529 4 GP GP NNP cord-302530-pp6bl941 529 5 / / SYM cord-302530-pp6bl941 529 6 Cr cr NN cord-302530-pp6bl941 529 7 binding bind VBG cord-302530-pp6bl941 529 8 affinity affinity NN cord-302530-pp6bl941 529 9 with with IN cord-302530-pp6bl941 529 10 temperature temperature NN cord-302530-pp6bl941 529 11 for for IN cord-302530-pp6bl941 529 12 HIV HIV NNP cord-302530-pp6bl941 529 13 Env Env NNP cord-302530-pp6bl941 529 14 : : : cord-302530-pp6bl941 529 15 CD4 CD4 NNP cord-302530-pp6bl941 529 16 is be VBZ cord-302530-pp6bl941 529 17 apparent apparent JJ cord-302530-pp6bl941 529 18 from from IN cord-302530-pp6bl941 529 19 the the DT cord-302530-pp6bl941 529 20 K K NNP cord-302530-pp6bl941 529 21 a_virus_T a_virus_T NNP cord-302530-pp6bl941 529 22 values value NNS cord-302530-pp6bl941 529 23 in in IN cord-302530-pp6bl941 529 24 Fig Fig NNP cord-302530-pp6bl941 529 25 . . . cord-302530-pp6bl941 530 1 5a 5a CD cord-302530-pp6bl941 530 2 and and CC cord-302530-pp6bl941 530 3 the the DT cord-302530-pp6bl941 530 4 increase increase NN cord-302530-pp6bl941 530 5 in in IN cord-302530-pp6bl941 530 6 the the DT cord-302530-pp6bl941 530 7 values value NNS cord-302530-pp6bl941 530 8 of of IN cord-302530-pp6bl941 530 9 K K NNP cord-302530-pp6bl941 530 10 d_receptor_T d_receptor_t CD cord-302530-pp6bl941 530 11 for for IN cord-302530-pp6bl941 530 12 the the DT cord-302530-pp6bl941 530 13 temperatures temperature NNS cord-302530-pp6bl941 530 14 4 4 CD cord-302530-pp6bl941 530 15 ° ° NN cord-302530-pp6bl941 530 16 C c NN cord-302530-pp6bl941 530 17 , , , cord-302530-pp6bl941 530 18 25 25 CD cord-302530-pp6bl941 530 19 ° ° NN cord-302530-pp6bl941 530 20 C c NN cord-302530-pp6bl941 530 21 and and CC cord-302530-pp6bl941 530 22 37 37 CD cord-302530-pp6bl941 530 23 ° ° NN cord-302530-pp6bl941 530 24 C c NN cord-302530-pp6bl941 530 25 in in IN cord-302530-pp6bl941 530 26 Table Table NNP cord-302530-pp6bl941 530 27 4 4 CD cord-302530-pp6bl941 530 28 . . . cord-302530-pp6bl941 531 1 Previously previously RB cord-302530-pp6bl941 531 2 a a DT cord-302530-pp6bl941 531 3 thermodynamic thermodynamic JJ cord-302530-pp6bl941 531 4 model model NN cord-302530-pp6bl941 531 5 for for IN cord-302530-pp6bl941 531 6 the the DT cord-302530-pp6bl941 531 7 effect effect NN cord-302530-pp6bl941 531 8 of of IN cord-302530-pp6bl941 531 9 temperature temperature NN cord-302530-pp6bl941 531 10 on on IN cord-302530-pp6bl941 531 11 arthropod arthropod JJ cord-302530-pp6bl941 531 12 vector vector NN cord-302530-pp6bl941 531 13 competence competence NN cord-302530-pp6bl941 531 14 was be VBD cord-302530-pp6bl941 531 15 developed develop VBN cord-302530-pp6bl941 531 16 ( ( -LRB- cord-302530-pp6bl941 531 17 Gale Gale NNP cord-302530-pp6bl941 531 18 2019 2019 CD cord-302530-pp6bl941 531 19 ) ) -RRB- cord-302530-pp6bl941 531 20 based base VBN cord-302530-pp6bl941 531 21 on on IN cord-302530-pp6bl941 531 22 the the DT cord-302530-pp6bl941 531 23 parameters parameter NNS cord-302530-pp6bl941 531 24 ΔH ΔH NNP cord-302530-pp6bl941 531 25 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 531 26 , , , cord-302530-pp6bl941 531 27 ΔS ΔS NNP cord-302530-pp6bl941 531 28 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 531 29 , , , cord-302530-pp6bl941 531 30 ΔS ΔS NNP cord-302530-pp6bl941 531 31 a_immob a_immob NNP cord-302530-pp6bl941 531 32 and and CC cord-302530-pp6bl941 531 33 n n NNP cord-302530-pp6bl941 531 34 , , , cord-302530-pp6bl941 531 35 together together RB cord-302530-pp6bl941 531 36 with with IN cord-302530-pp6bl941 531 37 the the DT cord-302530-pp6bl941 531 38 kinetic kinetic JJ cord-302530-pp6bl941 531 39 parameters parameter NNS cord-302530-pp6bl941 531 40 , , , cord-302530-pp6bl941 531 41 p p NN cord-302530-pp6bl941 531 42 complete283 complete283 NN cord-302530-pp6bl941 531 43 and and CC cord-302530-pp6bl941 531 44 E E NNP cord-302530-pp6bl941 531 45 A a NN cord-302530-pp6bl941 532 1 ( ( -LRB- cord-302530-pp6bl941 532 2 Table table NN cord-302530-pp6bl941 532 3 2 2 CD cord-302530-pp6bl941 532 4 ) ) -RRB- cord-302530-pp6bl941 532 5 . . . cord-302530-pp6bl941 533 1 This this DT cord-302530-pp6bl941 533 2 paper paper NN cord-302530-pp6bl941 533 3 furthers further VBZ cord-302530-pp6bl941 533 4 that that DT cord-302530-pp6bl941 533 5 model model NN cord-302530-pp6bl941 533 6 by by IN cord-302530-pp6bl941 533 7 allowing allow VBG cord-302530-pp6bl941 533 8 the the DT cord-302530-pp6bl941 533 9 change change NN cord-302530-pp6bl941 533 10 in in IN cord-302530-pp6bl941 533 11 heat heat NN cord-302530-pp6bl941 533 12 capacity capacity NN cord-302530-pp6bl941 533 13 , , , cord-302530-pp6bl941 533 14 ΔC ΔC NNP cord-302530-pp6bl941 533 15 p p NNP cord-302530-pp6bl941 533 16 , , , cord-302530-pp6bl941 533 17 on on IN cord-302530-pp6bl941 533 18 GP GP NNP cord-302530-pp6bl941 533 19 / / SYM cord-302530-pp6bl941 533 20 Cr cr NN cord-302530-pp6bl941 533 21 binding binding NN cord-302530-pp6bl941 533 22 to to TO cord-302530-pp6bl941 533 23 be be VB cord-302530-pp6bl941 533 24 included include VBN cord-302530-pp6bl941 533 25 . . . cord-302530-pp6bl941 534 1 This this DT cord-302530-pp6bl941 534 2 is be VBZ cord-302530-pp6bl941 534 3 important important JJ cord-302530-pp6bl941 534 4 because because IN cord-302530-pp6bl941 534 5 it -PRON- PRP cord-302530-pp6bl941 534 6 defines define VBZ cord-302530-pp6bl941 534 7 the the DT cord-302530-pp6bl941 534 8 effect effect NN cord-302530-pp6bl941 534 9 of of IN cord-302530-pp6bl941 534 10 temperature temperature NN cord-302530-pp6bl941 534 11 on on IN cord-302530-pp6bl941 534 12 ΔH ΔH NNP cord-302530-pp6bl941 534 13 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 535 1 ( ( -LRB- cord-302530-pp6bl941 535 2 Eq Eq NNP cord-302530-pp6bl941 535 3 . . . cord-302530-pp6bl941 536 1 ( ( -LRB- cord-302530-pp6bl941 536 2 4 4 LS cord-302530-pp6bl941 536 3 ) ) -RRB- cord-302530-pp6bl941 536 4 ) ) -RRB- cord-302530-pp6bl941 537 1 and and CC cord-302530-pp6bl941 537 2 ΔS ΔS NNP cord-302530-pp6bl941 537 3 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 538 1 ( ( -LRB- cord-302530-pp6bl941 538 2 Eq Eq NNP cord-302530-pp6bl941 538 3 . . . cord-302530-pp6bl941 539 1 ( ( -LRB- cord-302530-pp6bl941 539 2 6 6 CD cord-302530-pp6bl941 539 3 ) ) -RRB- cord-302530-pp6bl941 539 4 ) ) -RRB- cord-302530-pp6bl941 540 1 and and CC cord-302530-pp6bl941 540 2 hence hence RB cord-302530-pp6bl941 540 3 K K NNP cord-302530-pp6bl941 540 4 a_virus_T a_virus_T NNP cord-302530-pp6bl941 540 5 . . . cord-302530-pp6bl941 541 1 Of of IN cord-302530-pp6bl941 541 2 potentially potentially RB cord-302530-pp6bl941 541 3 greater great JJR cord-302530-pp6bl941 541 4 importance importance NN cord-302530-pp6bl941 541 5 , , , cord-302530-pp6bl941 541 6 however however RB cord-302530-pp6bl941 541 7 , , , cord-302530-pp6bl941 541 8 is be VBZ cord-302530-pp6bl941 541 9 the the DT cord-302530-pp6bl941 541 10 parameter parameter NN cord-302530-pp6bl941 541 11 ΔS ΔS NNP cord-302530-pp6bl941 541 12 a_immob a_immob NNP cord-302530-pp6bl941 541 13 first first RB cord-302530-pp6bl941 541 14 formally formally RB cord-302530-pp6bl941 541 15 identified identify VBN cord-302530-pp6bl941 541 16 in in IN cord-302530-pp6bl941 541 17 the the DT cord-302530-pp6bl941 541 18 thermodynamic thermodynamic JJ cord-302530-pp6bl941 541 19 analysis analysis NN cord-302530-pp6bl941 541 20 of of IN cord-302530-pp6bl941 541 21 virus virus NN cord-302530-pp6bl941 541 22 binding bind VBG cord-302530-pp6bl941 541 23 ( ( -LRB- cord-302530-pp6bl941 541 24 Gale Gale NNP cord-302530-pp6bl941 541 25 2019 2019 CD cord-302530-pp6bl941 541 26 ) ) -RRB- cord-302530-pp6bl941 541 27 . . . cord-302530-pp6bl941 542 1 Thus thus RB cord-302530-pp6bl941 542 2 it -PRON- PRP cord-302530-pp6bl941 542 3 is be VBZ cord-302530-pp6bl941 542 4 proposed propose VBN cord-302530-pp6bl941 542 5 here here RB cord-302530-pp6bl941 542 6 that that IN cord-302530-pp6bl941 542 7 the the DT cord-302530-pp6bl941 542 8 value value NN cord-302530-pp6bl941 542 9 of of IN cord-302530-pp6bl941 542 10 ΔS ΔS NNP cord-302530-pp6bl941 542 11 a_immob a_immob NNP cord-302530-pp6bl941 542 12 is be VBZ cord-302530-pp6bl941 542 13 not not RB cord-302530-pp6bl941 542 14 only only RB cord-302530-pp6bl941 542 15 important important JJ cord-302530-pp6bl941 542 16 in in IN cord-302530-pp6bl941 542 17 explaining explain VBG cord-302530-pp6bl941 542 18 the the DT cord-302530-pp6bl941 542 19 observation observation NN cord-302530-pp6bl941 542 20 that that IN cord-302530-pp6bl941 542 21 dsDNA dsdna RB cord-302530-pp6bl941 542 22 viruses virus NNS cord-302530-pp6bl941 542 23 infecting infect VBG cord-302530-pp6bl941 542 24 warmer warm JJR cord-302530-pp6bl941 542 25 hosts host NNS cord-302530-pp6bl941 542 26 are be VBP cord-302530-pp6bl941 542 27 generally generally RB cord-302530-pp6bl941 542 28 smaller small JJR cord-302530-pp6bl941 542 29 in in IN cord-302530-pp6bl941 542 30 volume volume NN cord-302530-pp6bl941 542 31 than than IN cord-302530-pp6bl941 542 32 those those DT cord-302530-pp6bl941 542 33 infecting infect VBG cord-302530-pp6bl941 542 34 colder cold JJR cord-302530-pp6bl941 542 35 hosts host NNS cord-302530-pp6bl941 542 36 ( ( -LRB- cord-302530-pp6bl941 542 37 Nifong Nifong NNP cord-302530-pp6bl941 542 38 and and CC cord-302530-pp6bl941 542 39 Gillooly Gillooly NNP cord-302530-pp6bl941 542 40 2016 2016 CD cord-302530-pp6bl941 542 41 ) ) -RRB- cord-302530-pp6bl941 542 42 but but CC cord-302530-pp6bl941 542 43 also also RB cord-302530-pp6bl941 542 44 may may MD cord-302530-pp6bl941 542 45 contribute contribute VB cord-302530-pp6bl941 542 46 to to IN cord-302530-pp6bl941 542 47 explaining explain VBG cord-302530-pp6bl941 542 48 the the DT cord-302530-pp6bl941 542 49 need need NN cord-302530-pp6bl941 542 50 for for IN cord-302530-pp6bl941 542 51 attachment attachment NN cord-302530-pp6bl941 542 52 factors factor NNS cord-302530-pp6bl941 542 53 to to TO cord-302530-pp6bl941 542 54 allow allow VB cord-302530-pp6bl941 542 55 binding binding NN cord-302530-pp6bl941 542 56 of of IN cord-302530-pp6bl941 542 57 a a DT cord-302530-pp6bl941 542 58 large large JJ cord-302530-pp6bl941 542 59 virus virus NN cord-302530-pp6bl941 542 60 such such JJ cord-302530-pp6bl941 542 61 as as IN cord-302530-pp6bl941 542 62 HIV HIV NNP cord-302530-pp6bl941 542 63 at at IN cord-302530-pp6bl941 542 64 the the DT cord-302530-pp6bl941 542 65 relatively relatively RB cord-302530-pp6bl941 542 66 high high JJ cord-302530-pp6bl941 542 67 human human JJ cord-302530-pp6bl941 542 68 body body NN cord-302530-pp6bl941 542 69 temperature temperature NN cord-302530-pp6bl941 542 70 of of IN cord-302530-pp6bl941 542 71 37 37 CD cord-302530-pp6bl941 542 72 ° ° NN cord-302530-pp6bl941 542 73 C c NN cord-302530-pp6bl941 542 74 . . . cord-302530-pp6bl941 543 1 This this DT cord-302530-pp6bl941 543 2 has have VBZ cord-302530-pp6bl941 543 3 implications implication NNS cord-302530-pp6bl941 543 4 for for IN cord-302530-pp6bl941 543 5 the the DT cord-302530-pp6bl941 543 6 design design NN cord-302530-pp6bl941 543 7 of of IN cord-302530-pp6bl941 543 8 novel novel JJ cord-302530-pp6bl941 543 9 antiviral antiviral JJ cord-302530-pp6bl941 543 10 therapies therapy NNS cord-302530-pp6bl941 543 11 . . . cord-302530-pp6bl941 544 1 The the DT cord-302530-pp6bl941 544 2 mechanistic mechanistic JJ cord-302530-pp6bl941 544 3 model model NN cord-302530-pp6bl941 544 4 developed develop VBN cord-302530-pp6bl941 544 5 here here RB cord-302530-pp6bl941 544 6 for for IN cord-302530-pp6bl941 544 7 HIV HIV NNP cord-302530-pp6bl941 544 8 goes go VBZ cord-302530-pp6bl941 544 9 as as RB cord-302530-pp6bl941 544 10 far far RB cord-302530-pp6bl941 544 11 as as IN cord-302530-pp6bl941 544 12 cell cell NN cord-302530-pp6bl941 544 13 binding binding NN cord-302530-pp6bl941 544 14 and and CC cord-302530-pp6bl941 544 15 viral viral JJ cord-302530-pp6bl941 544 16 membrane membrane NN cord-302530-pp6bl941 544 17 fusion fusion NN cord-302530-pp6bl941 544 18 ( ( -LRB- cord-302530-pp6bl941 544 19 Harrison Harrison NNP cord-302530-pp6bl941 544 20 2015 2015 CD cord-302530-pp6bl941 544 21 ) ) -RRB- cord-302530-pp6bl941 544 22 could could MD cord-302530-pp6bl941 544 23 be be VB cord-302530-pp6bl941 544 24 added add VBN cord-302530-pp6bl941 544 25 as as IN cord-302530-pp6bl941 544 26 the the DT cord-302530-pp6bl941 544 27 next next JJ cord-302530-pp6bl941 544 28 stage stage NN cord-302530-pp6bl941 544 29 to to TO cord-302530-pp6bl941 544 30 complete complete VB cord-302530-pp6bl941 544 31 the the DT cord-302530-pp6bl941 544 32 cell cell NN cord-302530-pp6bl941 544 33 entry entry NN cord-302530-pp6bl941 544 34 process process NN cord-302530-pp6bl941 544 35 . . . cord-302530-pp6bl941 545 1 Calculations calculation NNS cord-302530-pp6bl941 545 2 using use VBG cord-302530-pp6bl941 545 3 Eq Eq NNP cord-302530-pp6bl941 545 4 . . . cord-302530-pp6bl941 546 1 ( ( -LRB- cord-302530-pp6bl941 546 2 17 17 CD cord-302530-pp6bl941 546 3 ) ) -RRB- cord-302530-pp6bl941 546 4 on on IN cord-302530-pp6bl941 546 5 the the DT cord-302530-pp6bl941 546 6 basis basis NN cord-302530-pp6bl941 546 7 of of IN cord-302530-pp6bl941 546 8 limited limited JJ cord-302530-pp6bl941 546 9 available available JJ cord-302530-pp6bl941 546 10 data datum NNS cord-302530-pp6bl941 546 11 suggest suggest VBP cord-302530-pp6bl941 546 12 ΔS ΔS NNP cord-302530-pp6bl941 546 13 a_immob~− a_immob~− RB cord-302530-pp6bl941 547 1 1100 1100 CD cord-302530-pp6bl941 547 2 J J NNP cord-302530-pp6bl941 547 3 / / SYM cord-302530-pp6bl941 547 4 mol mol NNP cord-302530-pp6bl941 547 5 / / SYM cord-302530-pp6bl941 547 6 K K NNP cord-302530-pp6bl941 547 7 for for IN cord-302530-pp6bl941 547 8 HIV HIV NNP cord-302530-pp6bl941 548 1 although although IN cord-302530-pp6bl941 548 2 it -PRON- PRP cord-302530-pp6bl941 548 3 is be VBZ cord-302530-pp6bl941 548 4 acknowledged acknowledge VBN cord-302530-pp6bl941 548 5 above above IN cord-302530-pp6bl941 548 6 that that IN cord-302530-pp6bl941 548 7 there there EX cord-302530-pp6bl941 548 8 is be VBZ cord-302530-pp6bl941 548 9 considerable considerable JJ cord-302530-pp6bl941 548 10 uncertainty uncertainty NN cord-302530-pp6bl941 548 11 in in IN cord-302530-pp6bl941 548 12 the the DT cord-302530-pp6bl941 548 13 absence absence NN cord-302530-pp6bl941 548 14 of of IN cord-302530-pp6bl941 548 15 definitive definitive JJ cord-302530-pp6bl941 548 16 experimental experimental JJ cord-302530-pp6bl941 548 17 data datum NNS cord-302530-pp6bl941 548 18 . . . cord-302530-pp6bl941 549 1 It -PRON- PRP cord-302530-pp6bl941 549 2 is be VBZ cord-302530-pp6bl941 549 3 possible possible JJ cord-302530-pp6bl941 549 4 that that IN cord-302530-pp6bl941 549 5 statistical statistical JJ cord-302530-pp6bl941 549 6 thermodynamics thermodynamic NNS cord-302530-pp6bl941 549 7 approaches approach NNS cord-302530-pp6bl941 549 8 analogous analogous JJ cord-302530-pp6bl941 549 9 to to IN cord-302530-pp6bl941 549 10 the the DT cord-302530-pp6bl941 549 11 Sackur Sackur NNP cord-302530-pp6bl941 549 12 - - HYPH cord-302530-pp6bl941 549 13 Tetrode Tetrode NNP cord-302530-pp6bl941 549 14 equation equation NN cord-302530-pp6bl941 549 15 for for IN cord-302530-pp6bl941 549 16 the the DT cord-302530-pp6bl941 549 17 entropy entropy NN cord-302530-pp6bl941 549 18 of of IN cord-302530-pp6bl941 549 19 a a DT cord-302530-pp6bl941 549 20 gas gas NN cord-302530-pp6bl941 549 21 may may MD cord-302530-pp6bl941 549 22 be be VB cord-302530-pp6bl941 549 23 developed develop VBN cord-302530-pp6bl941 549 24 to to TO cord-302530-pp6bl941 549 25 estimate estimate VB cord-302530-pp6bl941 549 26 ΔS ΔS NNP cord-302530-pp6bl941 549 27 a_immob a_immob NNP cord-302530-pp6bl941 549 28 theoretically theoretically RB cord-302530-pp6bl941 549 29 . . . cord-302530-pp6bl941 550 1 The the DT cord-302530-pp6bl941 550 2 large large JJ cord-302530-pp6bl941 550 3 size size NN cord-302530-pp6bl941 550 4 of of IN cord-302530-pp6bl941 550 5 the the DT cord-302530-pp6bl941 550 6 HIV HIV NNP cord-302530-pp6bl941 550 7 virion virion NN cord-302530-pp6bl941 550 8 ( ( -LRB- cord-302530-pp6bl941 550 9 134 134 CD cord-302530-pp6bl941 550 10 nm nm NN cord-302530-pp6bl941 550 11 mean mean NN cord-302530-pp6bl941 550 12 diameter diameter NN cord-302530-pp6bl941 550 13 ) ) -RRB- cord-302530-pp6bl941 550 14 compared compare VBN cord-302530-pp6bl941 550 15 to to IN cord-302530-pp6bl941 550 16 a a DT cord-302530-pp6bl941 550 17 typical typical JJ cord-302530-pp6bl941 550 18 arbovirus arbovirus NN cord-302530-pp6bl941 550 19 ( ( -LRB- cord-302530-pp6bl941 550 20 50 50 CD cord-302530-pp6bl941 550 21 to to TO cord-302530-pp6bl941 550 22 70 70 CD cord-302530-pp6bl941 550 23 nm nm NN cord-302530-pp6bl941 550 24 diameter diameter NN cord-302530-pp6bl941 550 25 ) ) -RRB- cord-302530-pp6bl941 550 26 is be VBZ cord-302530-pp6bl941 550 27 consistent consistent JJ cord-302530-pp6bl941 550 28 with with IN cord-302530-pp6bl941 550 29 a a DT cord-302530-pp6bl941 550 30 more more RBR cord-302530-pp6bl941 550 31 negative negative JJ cord-302530-pp6bl941 550 32 value value NN cord-302530-pp6bl941 550 33 of of IN cord-302530-pp6bl941 550 34 ΔS ΔS NNP cord-302530-pp6bl941 550 35 a_immob a_immob NNP cord-302530-pp6bl941 550 36 providing provide VBG cord-302530-pp6bl941 550 37 justification justification NN cord-302530-pp6bl941 550 38 for for IN cord-302530-pp6bl941 550 39 the the DT cord-302530-pp6bl941 550 40 more more RBR cord-302530-pp6bl941 550 41 negative negative JJ cord-302530-pp6bl941 550 42 ΔS ΔS NNP cord-302530-pp6bl941 550 43 a_immob a_immob NNP cord-302530-pp6bl941 550 44 values value NNS cord-302530-pp6bl941 550 45 used use VBN cord-302530-pp6bl941 550 46 here here RB cord-302530-pp6bl941 550 47 for for IN cord-302530-pp6bl941 550 48 the the DT cord-302530-pp6bl941 550 49 HIV HIV NNP cord-302530-pp6bl941 550 50 models model NNS cord-302530-pp6bl941 550 51 in in IN cord-302530-pp6bl941 550 52 Figs Figs NNP cord-302530-pp6bl941 550 53 . . . cord-302530-pp6bl941 551 1 4 4 LS cord-302530-pp6bl941 551 2 - - SYM cord-302530-pp6bl941 551 3 6 6 CD cord-302530-pp6bl941 551 4 compared compare VBN cord-302530-pp6bl941 551 5 to to IN cord-302530-pp6bl941 551 6 that that DT cord-302530-pp6bl941 551 7 used use VBN cord-302530-pp6bl941 551 8 for for IN cord-302530-pp6bl941 551 9 the the DT cord-302530-pp6bl941 551 10 arbovirus arbovirus NN cord-302530-pp6bl941 551 11 models model NNS cord-302530-pp6bl941 551 12 in in IN cord-302530-pp6bl941 551 13 Figs Figs NNP cord-302530-pp6bl941 551 14 . . . cord-302530-pp6bl941 552 1 2 2 CD cord-302530-pp6bl941 552 2 and and CC cord-302530-pp6bl941 552 3 3 3 CD cord-302530-pp6bl941 552 4 . . . cord-302530-pp6bl941 553 1 Figs fig NNS cord-302530-pp6bl941 553 2 . . . cord-302530-pp6bl941 554 1 2 2 LS cord-302530-pp6bl941 554 2 - - SYM cord-302530-pp6bl941 554 3 5 5 CD cord-302530-pp6bl941 554 4 show show VBP cord-302530-pp6bl941 554 5 the the DT cord-302530-pp6bl941 554 6 variation variation NN cord-302530-pp6bl941 554 7 of of IN cord-302530-pp6bl941 554 8 K K NNP cord-302530-pp6bl941 554 9 a_virus_T a_virus_T NNP cord-302530-pp6bl941 554 10 and and CC cord-302530-pp6bl941 554 11 C.V C.V NNP cord-302530-pp6bl941 554 12 T T NNP cord-302530-pp6bl941 554 13 with with IN cord-302530-pp6bl941 554 14 temperature temperature NN cord-302530-pp6bl941 554 15 as as IN cord-302530-pp6bl941 554 16 predicted predict VBN cord-302530-pp6bl941 554 17 by by IN cord-302530-pp6bl941 554 18 models model NNS cord-302530-pp6bl941 554 19 assuming assume VBG cord-302530-pp6bl941 554 20 C C NNP cord-302530-pp6bl941 554 21 total total NN cord-302530-pp6bl941 554 22 = = SYM cord-302530-pp6bl941 554 23 10 10 CD cord-302530-pp6bl941 554 24 3 3 CD cord-302530-pp6bl941 554 25 host host NN cord-302530-pp6bl941 554 26 cells cell NNS cord-302530-pp6bl941 554 27 in in IN cord-302530-pp6bl941 554 28 a a DT cord-302530-pp6bl941 554 29 10 10 CD cord-302530-pp6bl941 554 30 −6 −6 NN cord-302530-pp6bl941 554 31 dm dm NN cord-302530-pp6bl941 554 32 3 3 CD cord-302530-pp6bl941 554 33 volume volume NN cord-302530-pp6bl941 554 34 ( ( -LRB- cord-302530-pp6bl941 554 35 i.e. i.e. FW cord-302530-pp6bl941 554 36 mosquito mosquito JJ cord-302530-pp6bl941 554 37 midgut midgut NN cord-302530-pp6bl941 554 38 or or CC cord-302530-pp6bl941 554 39 human human JJ cord-302530-pp6bl941 554 40 blood blood NN cord-302530-pp6bl941 554 41 sample sample NN cord-302530-pp6bl941 554 42 ) ) -RRB- cord-302530-pp6bl941 554 43 challenged challenge VBD cord-302530-pp6bl941 554 44 with with IN cord-302530-pp6bl941 554 45 V V NNP cord-302530-pp6bl941 554 46 total total NN cord-302530-pp6bl941 554 47 = = SYM cord-302530-pp6bl941 554 48 10 10 CD cord-302530-pp6bl941 554 49 5 5 CD cord-302530-pp6bl941 554 50 virions virion NNS cord-302530-pp6bl941 554 51 . . . cord-302530-pp6bl941 555 1 Previously previously RB cord-302530-pp6bl941 555 2 it -PRON- PRP cord-302530-pp6bl941 555 3 was be VBD cord-302530-pp6bl941 555 4 shown show VBN cord-302530-pp6bl941 555 5 that that IN cord-302530-pp6bl941 555 6 if if IN cord-302530-pp6bl941 555 7 K K NNP cord-302530-pp6bl941 555 8 a_virus_T a_virus_T NNP cord-302530-pp6bl941 555 9 > > XX cord-302530-pp6bl941 555 10 ~10 ~10 CD cord-302530-pp6bl941 555 11 14 14 CD cord-302530-pp6bl941 555 12 M M NNP cord-302530-pp6bl941 555 13 −1 −1 NNP cord-302530-pp6bl941 555 14 then then RB cord-302530-pp6bl941 555 15 nearly nearly RB cord-302530-pp6bl941 555 16 all all PDT cord-302530-pp6bl941 555 17 the the DT cord-302530-pp6bl941 555 18 host host NN cord-302530-pp6bl941 555 19 cells cell NNS cord-302530-pp6bl941 555 20 have have VBP cord-302530-pp6bl941 555 21 bound bind VBN cord-302530-pp6bl941 555 22 virus virus NN cord-302530-pp6bl941 555 23 at at IN cord-302530-pp6bl941 555 24 such such PDT cord-302530-pp6bl941 555 25 a a DT cord-302530-pp6bl941 555 26 high high JJ cord-302530-pp6bl941 555 27 virus virus NN cord-302530-pp6bl941 555 28 dose dose NN cord-302530-pp6bl941 555 29 ( ( -LRB- cord-302530-pp6bl941 555 30 Gale Gale NNP cord-302530-pp6bl941 555 31 2018 2018 CD cord-302530-pp6bl941 555 32 ; ; : cord-302530-pp6bl941 555 33 2019 2019 CD cord-302530-pp6bl941 555 34 ) ) -RRB- cord-302530-pp6bl941 555 35 . . . cord-302530-pp6bl941 556 1 Thus thus RB cord-302530-pp6bl941 556 2 the the DT cord-302530-pp6bl941 556 3 K K NNP cord-302530-pp6bl941 556 4 a_virus_T a_virus_T NNP cord-302530-pp6bl941 556 5 plots plot NNS cord-302530-pp6bl941 556 6 and and CC cord-302530-pp6bl941 556 7 corresponding correspond VBG cord-302530-pp6bl941 556 8 C.V C.V NNP cord-302530-pp6bl941 556 9 T T NNP cord-302530-pp6bl941 556 10 plots plot NNS cord-302530-pp6bl941 556 11 are be VBP cord-302530-pp6bl941 556 12 best well RBS cord-302530-pp6bl941 556 13 interpreted interpret VBN cord-302530-pp6bl941 556 14 in in IN cord-302530-pp6bl941 556 15 terms term NNS cord-302530-pp6bl941 556 16 of of IN cord-302530-pp6bl941 556 17 the the DT cord-302530-pp6bl941 556 18 temperature temperature NN cord-302530-pp6bl941 556 19 ranges range VBZ cord-302530-pp6bl941 556 20 over over IN cord-302530-pp6bl941 556 21 which which WDT cord-302530-pp6bl941 556 22 K K NNP cord-302530-pp6bl941 556 23 a_virus_T a_virus_T NNP cord-302530-pp6bl941 556 24 < < XX cord-302530-pp6bl941 556 25 ~10 ~10 XX cord-302530-pp6bl941 556 26 14 14 CD cord-302530-pp6bl941 556 27 M M NNP cord-302530-pp6bl941 556 28 −1 −1 NNP cord-302530-pp6bl941 556 29 . . . cord-302530-pp6bl941 557 1 For for IN cord-302530-pp6bl941 557 2 the the DT cord-302530-pp6bl941 557 3 arbovirus arbovirus NN cord-302530-pp6bl941 557 4 models model NNS cord-302530-pp6bl941 557 5 in in IN cord-302530-pp6bl941 557 6 Figs Figs NNP cord-302530-pp6bl941 557 7 . . . cord-302530-pp6bl941 558 1 2 2 CD cord-302530-pp6bl941 558 2 and and CC cord-302530-pp6bl941 558 3 3 3 CD cord-302530-pp6bl941 558 4 , , , cord-302530-pp6bl941 558 5 the the DT cord-302530-pp6bl941 558 6 main main JJ cord-302530-pp6bl941 558 7 conclusion conclusion NN cord-302530-pp6bl941 558 8 regarding regard VBG cord-302530-pp6bl941 558 9 the the DT cord-302530-pp6bl941 558 10 change change NN cord-302530-pp6bl941 558 11 in in IN cord-302530-pp6bl941 558 12 heat heat NN cord-302530-pp6bl941 558 13 capacity capacity NN cord-302530-pp6bl941 558 14 on on IN cord-302530-pp6bl941 558 15 GP GP NNP cord-302530-pp6bl941 558 16 / / SYM cord-302530-pp6bl941 558 17 Cr cr NN cord-302530-pp6bl941 558 18 binding binding NN cord-302530-pp6bl941 558 19 is be VBZ cord-302530-pp6bl941 558 20 that that IN cord-302530-pp6bl941 558 21 as as IN cord-302530-pp6bl941 558 22 ΔC ΔC NNP cord-302530-pp6bl941 558 23 p p NNP cord-302530-pp6bl941 558 24 becomes become VBZ cord-302530-pp6bl941 558 25 more more RBR cord-302530-pp6bl941 558 26 negative negative JJ cord-302530-pp6bl941 558 27 so so IN cord-302530-pp6bl941 558 28 a a DT cord-302530-pp6bl941 558 29 peak peak NN cord-302530-pp6bl941 558 30 temperature temperature NN cord-302530-pp6bl941 558 31 for for IN cord-302530-pp6bl941 558 32 K K NNP cord-302530-pp6bl941 558 33 a_virus_T a_virus_T NNP cord-302530-pp6bl941 558 34 becomes become VBZ cord-302530-pp6bl941 558 35 apparent apparent JJ cord-302530-pp6bl941 558 36 such such JJ cord-302530-pp6bl941 558 37 that that IN cord-302530-pp6bl941 558 38 binding bind VBG cord-302530-pp6bl941 558 39 affinity affinity NN cord-302530-pp6bl941 558 40 falls fall VBZ cord-302530-pp6bl941 558 41 at at IN cord-302530-pp6bl941 558 42 lower low JJR cord-302530-pp6bl941 558 43 and and CC cord-302530-pp6bl941 558 44 higher high JJR cord-302530-pp6bl941 558 45 temperatures temperature NNS cord-302530-pp6bl941 558 46 , , , cord-302530-pp6bl941 558 47 directly directly RB cord-302530-pp6bl941 558 48 affecting affect VBG cord-302530-pp6bl941 558 49 C.V C.V NNP cord-302530-pp6bl941 558 50 T T NNP cord-302530-pp6bl941 558 51 when when WRB cord-302530-pp6bl941 558 52 K K NNP cord-302530-pp6bl941 558 53 a_virus_T a_virus_T NNP cord-302530-pp6bl941 558 54 falls fall VBZ cord-302530-pp6bl941 558 55 below below IN cord-302530-pp6bl941 558 56 10 10 CD cord-302530-pp6bl941 558 57 14 14 CD cord-302530-pp6bl941 558 58 M M NNP cord-302530-pp6bl941 558 59 −1 −1 NNP cord-302530-pp6bl941 558 60 . . . cord-302530-pp6bl941 559 1 Values value NNS cord-302530-pp6bl941 559 2 of of IN cord-302530-pp6bl941 559 3 ΔC ΔC NNP cord-302530-pp6bl941 559 4 p p NN cord-302530-pp6bl941 559 5 from from IN cord-302530-pp6bl941 559 6 0 0 CD cord-302530-pp6bl941 559 7 to~−2.0 to~−2.0 CD cord-302530-pp6bl941 560 1 kJ kJ NNP cord-302530-pp6bl941 560 2 / / SYM cord-302530-pp6bl941 560 3 mol mol NNP cord-302530-pp6bl941 560 4 / / SYM cord-302530-pp6bl941 560 5 K K NNP cord-302530-pp6bl941 560 6 have have VBP cord-302530-pp6bl941 560 7 relatively relatively RB cord-302530-pp6bl941 560 8 little little JJ cord-302530-pp6bl941 560 9 impact impact NN cord-302530-pp6bl941 560 10 on on IN cord-302530-pp6bl941 560 11 the the DT cord-302530-pp6bl941 560 12 temperature temperature NN cord-302530-pp6bl941 560 13 sensitivity sensitivity NN cord-302530-pp6bl941 560 14 of of IN cord-302530-pp6bl941 560 15 the the DT cord-302530-pp6bl941 560 16 number number NN cord-302530-pp6bl941 560 17 , , , cord-302530-pp6bl941 560 18 C.V C.V NNP cord-302530-pp6bl941 560 19 T T NNP cord-302530-pp6bl941 560 20 , , , cord-302530-pp6bl941 560 21 of of IN cord-302530-pp6bl941 560 22 mosquito mosquito NN cord-302530-pp6bl941 560 23 midgut midgut NN cord-302530-pp6bl941 560 24 cells cell NNS cord-302530-pp6bl941 560 25 with with IN cord-302530-pp6bl941 560 26 bound bind VBN cord-302530-pp6bl941 560 27 virus virus NN cord-302530-pp6bl941 560 28 ( ( -LRB- cord-302530-pp6bl941 560 29 Fig Fig NNP cord-302530-pp6bl941 560 30 . . . cord-302530-pp6bl941 560 31 2b 2b NNP cord-302530-pp6bl941 560 32 ) ) -RRB- cord-302530-pp6bl941 560 33 , , , cord-302530-pp6bl941 560 34 while while IN cord-302530-pp6bl941 560 35 intermediate intermediate JJ cord-302530-pp6bl941 560 36 values value NNS cord-302530-pp6bl941 560 37 of of IN cord-302530-pp6bl941 560 38 ΔC ΔC NNP cord-302530-pp6bl941 560 39 p p NN cord-302530-pp6bl941 560 40 of of IN cord-302530-pp6bl941 560 41 Fig Fig NNP cord-302530-pp6bl941 560 42 . . NNP cord-302530-pp6bl941 560 43 5 5 CD cord-302530-pp6bl941 560 44 . . . cord-302530-pp6bl941 561 1 Predicted predict VBN cord-302530-pp6bl941 561 2 effect effect NN cord-302530-pp6bl941 561 3 of of IN cord-302530-pp6bl941 561 4 ΔS ΔS NNP cord-302530-pp6bl941 561 5 a_immob a_immob NNP cord-302530-pp6bl941 561 6 on on IN cord-302530-pp6bl941 561 7 the the DT cord-302530-pp6bl941 561 8 temperature temperature NN cord-302530-pp6bl941 561 9 sensitivity sensitivity NN cord-302530-pp6bl941 561 10 of of IN cord-302530-pp6bl941 561 11 a a DT cord-302530-pp6bl941 561 12 ) ) -RRB- cord-302530-pp6bl941 561 13 K K NNP cord-302530-pp6bl941 561 14 a_virus_T a_virus_T NNP cord-302530-pp6bl941 561 15 and and CC cord-302530-pp6bl941 561 16 b b LS cord-302530-pp6bl941 561 17 ) ) -RRB- cord-302530-pp6bl941 562 1 the the DT cord-302530-pp6bl941 562 2 number number NN cord-302530-pp6bl941 562 3 of of IN cord-302530-pp6bl941 562 4 host host NN cord-302530-pp6bl941 562 5 CD4 CD4 NNP cord-302530-pp6bl941 562 6 + + CC cord-302530-pp6bl941 562 7 T t NN cord-302530-pp6bl941 562 8 cells cell NNS cord-302530-pp6bl941 562 9 , , , cord-302530-pp6bl941 562 10 C.V C.V NNP cord-302530-pp6bl941 562 11 T T NNP cord-302530-pp6bl941 562 12 , , , cord-302530-pp6bl941 562 13 with with IN cord-302530-pp6bl941 562 14 bound bind VBN cord-302530-pp6bl941 562 15 HIV HIV NNP cord-302530-pp6bl941 562 16 virions virion NNS cord-302530-pp6bl941 562 17 in in IN cord-302530-pp6bl941 562 18 a a DT cord-302530-pp6bl941 562 19 system system NN cord-302530-pp6bl941 562 20 comprising comprise VBG cord-302530-pp6bl941 562 21 C C NNP cord-302530-pp6bl941 562 22 total total NN cord-302530-pp6bl941 562 23 = = SYM cord-302530-pp6bl941 562 24 10 10 CD cord-302530-pp6bl941 562 25 3 3 CD cord-302530-pp6bl941 562 26 CD4 CD4 NNP cord-302530-pp6bl941 562 27 + + CC cord-302530-pp6bl941 562 28 host host NN cord-302530-pp6bl941 562 29 T t NN cord-302530-pp6bl941 562 30 cells cell NNS cord-302530-pp6bl941 562 31 in in IN cord-302530-pp6bl941 562 32 a a DT cord-302530-pp6bl941 562 33 1 1 CD cord-302530-pp6bl941 562 34 mm mm CD cord-302530-pp6bl941 562 35 3 3 CD cord-302530-pp6bl941 562 36 vol vol NN cord-302530-pp6bl941 562 37 of of IN cord-302530-pp6bl941 562 38 blood blood NN cord-302530-pp6bl941 562 39 with with IN cord-302530-pp6bl941 562 40 a a DT cord-302530-pp6bl941 562 41 challenge challenge NN cord-302530-pp6bl941 562 42 dose dose NN cord-302530-pp6bl941 562 43 of of IN cord-302530-pp6bl941 562 44 10 10 CD cord-302530-pp6bl941 562 45 5 5 CD cord-302530-pp6bl941 562 46 HIV HIV NNP cord-302530-pp6bl941 562 47 virions virion NNS cord-302530-pp6bl941 562 48 . . . cord-302530-pp6bl941 563 1 The the DT cord-302530-pp6bl941 563 2 values value NNS cord-302530-pp6bl941 563 3 of of IN cord-302530-pp6bl941 563 4 ΔH ΔH NNP cord-302530-pp6bl941 563 5 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 563 6 and and CC cord-302530-pp6bl941 563 7 ΔS ΔS NNP cord-302530-pp6bl941 563 8 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 563 9 at at IN cord-302530-pp6bl941 563 10 T t NN cord-302530-pp6bl941 563 11 0 0 CD cord-302530-pp6bl941 563 12 = = NFP cord-302530-pp6bl941 564 1 37 37 CD cord-302530-pp6bl941 564 2 ° ° NN cord-302530-pp6bl941 564 3 C c NN cord-302530-pp6bl941 564 4 for for IN cord-302530-pp6bl941 564 5 specific specific JJ cord-302530-pp6bl941 564 6 HIV HIV NNP cord-302530-pp6bl941 564 7 Env Env NNP cord-302530-pp6bl941 564 8 : : : cord-302530-pp6bl941 564 9 CD4 CD4 NNP cord-302530-pp6bl941 564 10 binding bind VBG cord-302530-pp6bl941 564 11 are be VBP cord-302530-pp6bl941 564 12 given give VBN cord-302530-pp6bl941 564 13 in in IN cord-302530-pp6bl941 564 14 Table Table NNP cord-302530-pp6bl941 564 15 4 4 CD cord-302530-pp6bl941 564 16 with with IN cord-302530-pp6bl941 564 17 n n NN cord-302530-pp6bl941 564 18 t= t= NNP cord-302530-pp6bl941 564 19 3 3 CD cord-302530-pp6bl941 564 20 Env Env NNP cord-302530-pp6bl941 564 21 : : : cord-302530-pp6bl941 564 22 CD4 CD4 NNP cord-302530-pp6bl941 564 23 specific specific JJ cord-302530-pp6bl941 564 24 interactions interaction NNS cord-302530-pp6bl941 564 25 and and CC cord-302530-pp6bl941 564 26 ΔC δc NN cord-302530-pp6bl941 564 27 p p NN cord-302530-pp6bl941 564 28 = = NN cord-302530-pp6bl941 564 29 −5.02 −5.02 NNP cord-302530-pp6bl941 564 30 kJ kJ NNP cord-302530-pp6bl941 564 31 / / SYM cord-302530-pp6bl941 564 32 mol mol NNP cord-302530-pp6bl941 564 33 / / SYM cord-302530-pp6bl941 564 34 K K NNP cord-302530-pp6bl941 564 35 ( ( -LRB- cord-302530-pp6bl941 564 36 Table Table NNP cord-302530-pp6bl941 564 37 3 3 CD cord-302530-pp6bl941 564 38 ) ) -RRB- cord-302530-pp6bl941 565 1 ~−3.0 ~−3.0 NNP cord-302530-pp6bl941 566 1 kJ kJ NNP cord-302530-pp6bl941 566 2 / / SYM cord-302530-pp6bl941 566 3 mol mol NNP cord-302530-pp6bl941 566 4 / / SYM cord-302530-pp6bl941 566 5 K K NNP cord-302530-pp6bl941 566 6 give give VBP cord-302530-pp6bl941 566 7 a a DT cord-302530-pp6bl941 566 8 peak peak NN cord-302530-pp6bl941 566 9 binding binding NN cord-302530-pp6bl941 566 10 at at IN cord-302530-pp6bl941 566 11 a a DT cord-302530-pp6bl941 566 12 temperature temperature NN cord-302530-pp6bl941 566 13 of~20 of~20 NNP cord-302530-pp6bl941 566 14 ° ° NN cord-302530-pp6bl941 566 15 C C NNP cord-302530-pp6bl941 566 16 as as IN cord-302530-pp6bl941 566 17 observed observe VBN cord-302530-pp6bl941 566 18 experimentally experimentally RB cord-302530-pp6bl941 566 19 for for IN cord-302530-pp6bl941 566 20 WEEV weev NN cord-302530-pp6bl941 566 21 binding bind VBG cord-302530-pp6bl941 566 22 to to IN cord-302530-pp6bl941 566 23 BBFs bbf NNS cord-302530-pp6bl941 566 24 from from IN cord-302530-pp6bl941 566 25 susceptible susceptible JJ cord-302530-pp6bl941 566 26 mosquito mosquito NN cord-302530-pp6bl941 566 27 midguts midgut NNS cord-302530-pp6bl941 566 28 in in IN cord-302530-pp6bl941 566 29 Fig Fig NNP cord-302530-pp6bl941 566 30 . . . cord-302530-pp6bl941 566 31 3b 3b CD cord-302530-pp6bl941 566 32 . . . cord-302530-pp6bl941 567 1 More more RBR cord-302530-pp6bl941 567 2 negative negative JJ cord-302530-pp6bl941 567 3 values value NNS cord-302530-pp6bl941 567 4 of of IN cord-302530-pp6bl941 567 5 ΔC ΔC NNP cord-302530-pp6bl941 567 6 p p NN cord-302530-pp6bl941 567 7 at at IN cord-302530-pp6bl941 567 8 −5.0 −5.0 NN cord-302530-pp6bl941 568 1 kJ/ kJ/ NNP cord-302530-pp6bl941 568 2 mol mol NNP cord-302530-pp6bl941 568 3 / / SYM cord-302530-pp6bl941 568 4 K K NNP cord-302530-pp6bl941 568 5 greatly greatly RB cord-302530-pp6bl941 568 6 diminish diminish VB cord-302530-pp6bl941 568 7 arbovirus arbovirus NN cord-302530-pp6bl941 568 8 binding bind VBG cord-302530-pp6bl941 568 9 affinity affinity NN cord-302530-pp6bl941 568 10 at at IN cord-302530-pp6bl941 568 11 temperatures temperature NNS cord-302530-pp6bl941 568 12 below~20 below~20 NNP cord-302530-pp6bl941 568 13 ° ° NN cord-302530-pp6bl941 568 14 C c NN cord-302530-pp6bl941 568 15 ( ( -LRB- cord-302530-pp6bl941 568 16 Fig Fig NNP cord-302530-pp6bl941 568 17 . . . cord-302530-pp6bl941 568 18 2b 2b LS cord-302530-pp6bl941 568 19 ) ) -RRB- cord-302530-pp6bl941 568 20 which which WDT cord-302530-pp6bl941 568 21 in in IN cord-302530-pp6bl941 568 22 turn turn NN cord-302530-pp6bl941 568 23 diminishes diminish VBZ cord-302530-pp6bl941 568 24 the the DT cord-302530-pp6bl941 568 25 transmission transmission NN cord-302530-pp6bl941 568 26 efficiency efficiency NN cord-302530-pp6bl941 568 27 of of IN cord-302530-pp6bl941 568 28 the the DT cord-302530-pp6bl941 568 29 arbovirus arbovirus NN cord-302530-pp6bl941 568 30 at at IN cord-302530-pp6bl941 568 31 temperatures temperature NNS cord-302530-pp6bl941 568 32 below below IN cord-302530-pp6bl941 568 33 20 20 CD cord-302530-pp6bl941 568 34 ° ° NN cord-302530-pp6bl941 568 35 C c NN cord-302530-pp6bl941 568 36 compared compare VBN cord-302530-pp6bl941 568 37 to to IN cord-302530-pp6bl941 568 38 GP/ GP/ NNP cord-302530-pp6bl941 568 39 Cr Cr NNP cord-302530-pp6bl941 568 40 systems system NNS cord-302530-pp6bl941 568 41 with with IN cord-302530-pp6bl941 568 42 ΔC ΔC NNP cord-302530-pp6bl941 568 43 p p NN cord-302530-pp6bl941 568 44 in in IN cord-302530-pp6bl941 568 45 the the DT cord-302530-pp6bl941 568 46 range range NN cord-302530-pp6bl941 568 47 of of IN cord-302530-pp6bl941 568 48 −2.0 −2.0 CD cord-302530-pp6bl941 568 49 to to IN cord-302530-pp6bl941 568 50 0 0 CD cord-302530-pp6bl941 568 51 kJ kJ NNP cord-302530-pp6bl941 568 52 / / SYM cord-302530-pp6bl941 568 53 mol mol NNP cord-302530-pp6bl941 568 54 / / SYM cord-302530-pp6bl941 568 55 K K NNP cord-302530-pp6bl941 568 56 ( ( -LRB- cord-302530-pp6bl941 568 57 Fig Fig NNP cord-302530-pp6bl941 568 58 . . . cord-302530-pp6bl941 568 59 2d 2d NNP cord-302530-pp6bl941 568 60 ) ) -RRB- cord-302530-pp6bl941 568 61 . . . cord-302530-pp6bl941 569 1 In in IN cord-302530-pp6bl941 569 2 evolutionary evolutionary JJ cord-302530-pp6bl941 569 3 terms term NNS cord-302530-pp6bl941 569 4 , , , cord-302530-pp6bl941 569 5 to to TO cord-302530-pp6bl941 569 6 optimise optimise VB cord-302530-pp6bl941 569 7 arbovirus arbovirus NN cord-302530-pp6bl941 569 8 infectivity infectivity NN cord-302530-pp6bl941 569 9 with with IN cord-302530-pp6bl941 569 10 n n NN cord-302530-pp6bl941 569 11 = = SYM cord-302530-pp6bl941 569 12 4 4 CD cord-302530-pp6bl941 569 13 GP GP NNP cord-302530-pp6bl941 569 14 / / SYM cord-302530-pp6bl941 569 15 Cr cr NN cord-302530-pp6bl941 569 16 interactions interaction NNS cord-302530-pp6bl941 569 17 over over IN cord-302530-pp6bl941 569 18 a a DT cord-302530-pp6bl941 569 19 range range NN cord-302530-pp6bl941 569 20 of of IN cord-302530-pp6bl941 569 21 temperatures temperature NNS cord-302530-pp6bl941 569 22 , , , cord-302530-pp6bl941 569 23 GP GP NNP cord-302530-pp6bl941 569 24 / / SYM cord-302530-pp6bl941 569 25 Cr cr NN cord-302530-pp6bl941 569 26 interactions interaction NNS cord-302530-pp6bl941 569 27 with with IN cord-302530-pp6bl941 569 28 small small JJ cord-302530-pp6bl941 569 29 ΔC ΔC NNP cord-302530-pp6bl941 569 30 p p NN cord-302530-pp6bl941 569 31 would would MD cord-302530-pp6bl941 569 32 be be VB cord-302530-pp6bl941 569 33 selected select VBN cord-302530-pp6bl941 569 34 as as IN cord-302530-pp6bl941 569 35 for for IN cord-302530-pp6bl941 569 36 AIV AIV NNP cord-302530-pp6bl941 569 37 HA HA NNP cord-302530-pp6bl941 569 38 / / SYM cord-302530-pp6bl941 569 39 SA SA NNP cord-302530-pp6bl941 569 40 binding binding NN cord-302530-pp6bl941 569 41 ( ( -LRB- cord-302530-pp6bl941 569 42 Table Table NNP cord-302530-pp6bl941 569 43 3 3 CD cord-302530-pp6bl941 569 44 ) ) -RRB- cord-302530-pp6bl941 569 45 . . . cord-302530-pp6bl941 570 1 It -PRON- PRP cord-302530-pp6bl941 570 2 is be VBZ cord-302530-pp6bl941 570 3 proposed propose VBN cord-302530-pp6bl941 570 4 here here RB cord-302530-pp6bl941 570 5 that that DT cord-302530-pp6bl941 570 6 to to TO cord-302530-pp6bl941 570 7 maintain maintain VB cord-302530-pp6bl941 570 8 some some DT cord-302530-pp6bl941 570 9 transmission transmission NN cord-302530-pp6bl941 570 10 efficiency efficiency NN cord-302530-pp6bl941 570 11 at at IN cord-302530-pp6bl941 570 12 lower low JJR cord-302530-pp6bl941 570 13 temperatures temperature NNS cord-302530-pp6bl941 570 14 , , , cord-302530-pp6bl941 570 15 arboviruses arbovirus NNS cord-302530-pp6bl941 570 16 may may MD cord-302530-pp6bl941 570 17 use use VB cord-302530-pp6bl941 570 18 SA SA NNP cord-302530-pp6bl941 570 19 binding bind VBG cord-302530-pp6bl941 570 20 interactions interaction NNS cord-302530-pp6bl941 570 21 as as IN cord-302530-pp6bl941 570 22 shown show VBN cord-302530-pp6bl941 570 23 for for IN cord-302530-pp6bl941 570 24 BTV BTV NNP cord-302530-pp6bl941 570 25 coat coat NN cord-302530-pp6bl941 570 26 protein protein NN cord-302530-pp6bl941 570 27 VP2 vp2 NN cord-302530-pp6bl941 570 28 ( ( -LRB- cord-302530-pp6bl941 570 29 Zhang Zhang NNP cord-302530-pp6bl941 570 30 et et NNP cord-302530-pp6bl941 570 31 al al NNP cord-302530-pp6bl941 570 32 . . NNP cord-302530-pp6bl941 570 33 , , , cord-302530-pp6bl941 570 34 2010 2010 CD cord-302530-pp6bl941 570 35 ) ) -RRB- cord-302530-pp6bl941 570 36 for for IN cord-302530-pp6bl941 570 37 which which WDT cord-302530-pp6bl941 570 38 ΔC ΔC NNP cord-302530-pp6bl941 570 39 p p NN cord-302530-pp6bl941 570 40 may may MD cord-302530-pp6bl941 570 41 approximate approximate VB cord-302530-pp6bl941 570 42 0 0 CD cord-302530-pp6bl941 570 43 kJ kJ NNP cord-302530-pp6bl941 570 44 / / SYM cord-302530-pp6bl941 570 45 mol mol NNP cord-302530-pp6bl941 570 46 / / SYM cord-302530-pp6bl941 570 47 K K NNP cord-302530-pp6bl941 570 48 as as IN cord-302530-pp6bl941 570 49 in in IN cord-302530-pp6bl941 570 50 the the DT cord-302530-pp6bl941 570 51 case case NN cord-302530-pp6bl941 570 52 of of IN cord-302530-pp6bl941 570 53 AIV AIV NNP cord-302530-pp6bl941 570 54 HA HA NNP cord-302530-pp6bl941 570 55 / / SYM cord-302530-pp6bl941 570 56 SA SA NNP cord-302530-pp6bl941 570 57 ( ( -LRB- cord-302530-pp6bl941 570 58 Table Table NNP cord-302530-pp6bl941 570 59 3 3 CD cord-302530-pp6bl941 570 60 ) ) -RRB- cord-302530-pp6bl941 570 61 . . . cord-302530-pp6bl941 571 1 This this DT cord-302530-pp6bl941 571 2 would would MD cord-302530-pp6bl941 571 3 facilitate facilitate VB cord-302530-pp6bl941 571 4 arboviruses arbovirus NNS cord-302530-pp6bl941 571 5 ' ' POS cord-302530-pp6bl941 571 6 expanding expand VBG cord-302530-pp6bl941 571 7 their -PRON- PRP$ cord-302530-pp6bl941 571 8 range range NN cord-302530-pp6bl941 571 9 into into IN cord-302530-pp6bl941 571 10 temperate temperate JJ cord-302530-pp6bl941 571 11 regions region NNS cord-302530-pp6bl941 571 12 of of IN cord-302530-pp6bl941 571 13 the the DT cord-302530-pp6bl941 571 14 world world NN cord-302530-pp6bl941 571 15 with with IN cord-302530-pp6bl941 571 16 climate climate NN cord-302530-pp6bl941 571 17 change change NN cord-302530-pp6bl941 571 18 . . . cord-302530-pp6bl941 572 1 With with IN cord-302530-pp6bl941 572 2 the the DT cord-302530-pp6bl941 572 3 reference reference NN cord-302530-pp6bl941 572 4 temperature temperature NN cord-302530-pp6bl941 572 5 of of IN cord-302530-pp6bl941 572 6 T t NN cord-302530-pp6bl941 572 7 0 0 CD cord-302530-pp6bl941 572 8 = = SYM cord-302530-pp6bl941 572 9 37 37 CD cord-302530-pp6bl941 572 10 ° ° NN cord-302530-pp6bl941 572 11 C c NN cord-302530-pp6bl941 572 12 , , , cord-302530-pp6bl941 572 13 C.V C.V NNP cord-302530-pp6bl941 572 14 T T NNP cord-302530-pp6bl941 572 15 falls fall VBZ cord-302530-pp6bl941 572 16 rapidly rapidly RB cord-302530-pp6bl941 572 17 at at IN cord-302530-pp6bl941 572 18 temperatures temperature NNS cord-302530-pp6bl941 572 19 above above IN cord-302530-pp6bl941 572 20 20 20 CD cord-302530-pp6bl941 572 21 ° ° NN cord-302530-pp6bl941 572 22 C c NN cord-302530-pp6bl941 572 23 in in IN cord-302530-pp6bl941 572 24 the the DT cord-302530-pp6bl941 572 25 arbovirus arbovirus NN cord-302530-pp6bl941 572 26 model model NN cord-302530-pp6bl941 572 27 here here RB cord-302530-pp6bl941 572 28 with with IN cord-302530-pp6bl941 572 29 n n NN cord-302530-pp6bl941 572 30 = = SYM cord-302530-pp6bl941 572 31 4 4 CD cord-302530-pp6bl941 572 32 GP/ GP/ NNP cord-302530-pp6bl941 572 33 Cr Cr NNP cord-302530-pp6bl941 572 34 interactions interaction NNS cord-302530-pp6bl941 572 35 irrespective irrespective RB cord-302530-pp6bl941 572 36 of of IN cord-302530-pp6bl941 572 37 the the DT cord-302530-pp6bl941 572 38 magnitude magnitude NN cord-302530-pp6bl941 572 39 of of IN cord-302530-pp6bl941 572 40 ΔC ΔC NNP cord-302530-pp6bl941 572 41 p p NN cord-302530-pp6bl941 572 42 ( ( -LRB- cord-302530-pp6bl941 572 43 Fig Fig NNP cord-302530-pp6bl941 572 44 . . . cord-302530-pp6bl941 572 45 2b 2b LS cord-302530-pp6bl941 572 46 ) ) -RRB- cord-302530-pp6bl941 572 47 as as IN cord-302530-pp6bl941 572 48 the the DT cord-302530-pp6bl941 572 49 K K NNP cord-302530-pp6bl941 572 50 a_virus_T a_virus_T NNP cord-302530-pp6bl941 572 51 values value NNS cord-302530-pp6bl941 572 52 fall fall VBP cord-302530-pp6bl941 572 53 below below IN cord-302530-pp6bl941 572 54 10 10 CD cord-302530-pp6bl941 572 55 14 14 CD cord-302530-pp6bl941 572 56 M M NNP cord-302530-pp6bl941 572 57 − − NNP cord-302530-pp6bl941 572 58 1 1 CD cord-302530-pp6bl941 572 59 and and CC cord-302530-pp6bl941 572 60 converge converge VB cord-302530-pp6bl941 572 61 at at IN cord-302530-pp6bl941 572 62 10 10 CD cord-302530-pp6bl941 572 63 12 12 CD cord-302530-pp6bl941 572 64 M M NNP cord-302530-pp6bl941 572 65 − − NNP cord-302530-pp6bl941 572 66 1 1 CD cord-302530-pp6bl941 572 67 at at IN cord-302530-pp6bl941 572 68 37 37 CD cord-302530-pp6bl941 572 69 ° ° NN cord-302530-pp6bl941 572 70 C c NN cord-302530-pp6bl941 572 71 ( ( -LRB- cord-302530-pp6bl941 572 72 Fig Fig NNP cord-302530-pp6bl941 572 73 . . . cord-302530-pp6bl941 572 74 2a 2a CD cord-302530-pp6bl941 572 75 ) ) -RRB- cord-302530-pp6bl941 572 76 . . . cord-302530-pp6bl941 573 1 This this DT cord-302530-pp6bl941 573 2 fall fall NN cord-302530-pp6bl941 573 3 is be VBZ cord-302530-pp6bl941 573 4 observed observe VBN cord-302530-pp6bl941 573 5 experimentally experimentally RB cord-302530-pp6bl941 573 6 as as IN cord-302530-pp6bl941 573 7 the the DT cord-302530-pp6bl941 573 8 temperature temperature NN cord-302530-pp6bl941 573 9 is be VBZ cord-302530-pp6bl941 573 10 increased increase VBN cord-302530-pp6bl941 573 11 from from IN cord-302530-pp6bl941 573 12 20 20 CD cord-302530-pp6bl941 573 13 ° ° NN cord-302530-pp6bl941 573 14 C c NN cord-302530-pp6bl941 573 15 to to IN cord-302530-pp6bl941 573 16 40 40 CD cord-302530-pp6bl941 573 17 ° ° NN cord-302530-pp6bl941 573 18 C c NN cord-302530-pp6bl941 573 19 ( ( -LRB- cord-302530-pp6bl941 573 20 Fig Fig NNP cord-302530-pp6bl941 573 21 . . . cord-302530-pp6bl941 573 22 3b 3b CD cord-302530-pp6bl941 573 23 ) ) -RRB- cord-302530-pp6bl941 573 24 for for IN cord-302530-pp6bl941 573 25 WEEV weev NN cord-302530-pp6bl941 573 26 binding bind VBG cord-302530-pp6bl941 573 27 to to IN cord-302530-pp6bl941 573 28 BBFs bbf NNS cord-302530-pp6bl941 573 29 from from IN cord-302530-pp6bl941 573 30 susceptible susceptible JJ cord-302530-pp6bl941 573 31 mosquito mosquito NN cord-302530-pp6bl941 573 32 midguts midgut NNS cord-302530-pp6bl941 573 33 as as IN cord-302530-pp6bl941 573 34 reported report VBN cord-302530-pp6bl941 573 35 by by IN cord-302530-pp6bl941 573 36 Houk Houk NNP cord-302530-pp6bl941 573 37 et et NNP cord-302530-pp6bl941 573 38 al al NNP cord-302530-pp6bl941 573 39 . . . cord-302530-pp6bl941 574 1 ( ( -LRB- cord-302530-pp6bl941 574 2 1990 1990 CD cord-302530-pp6bl941 574 3 ) ) -RRB- cord-302530-pp6bl941 574 4 . . . cord-302530-pp6bl941 575 1 4.4 4.4 CD cord-302530-pp6bl941 575 2 . . . cord-302530-pp6bl941 576 1 The the DT cord-302530-pp6bl941 576 2 large large JJ cord-302530-pp6bl941 576 3 negative negative JJ cord-302530-pp6bl941 576 4 ΔC ΔC NNP cord-302530-pp6bl941 576 5 p p NN cord-302530-pp6bl941 576 6 for for IN cord-302530-pp6bl941 576 7 HIV HIV NNP cord-302530-pp6bl941 577 1 gp120 gp120 NNP cord-302530-pp6bl941 577 2 : : : cord-302530-pp6bl941 578 1 CD4 CD4 NNP cord-302530-pp6bl941 578 2 diminishes diminish VBZ cord-302530-pp6bl941 578 3 binding bind VBG cord-302530-pp6bl941 578 4 at at IN cord-302530-pp6bl941 578 5 human human JJ cord-302530-pp6bl941 578 6 body body NN cord-302530-pp6bl941 578 7 temperature temperature NN cord-302530-pp6bl941 578 8 in in IN cord-302530-pp6bl941 578 9 the the DT cord-302530-pp6bl941 578 10 HIV HIV NNP cord-302530-pp6bl941 578 11 model model NN cord-302530-pp6bl941 579 1 The the DT cord-302530-pp6bl941 579 2 ΔC ΔC NNP cord-302530-pp6bl941 579 3 p p NN cord-302530-pp6bl941 579 4 for for IN cord-302530-pp6bl941 579 5 HIV HIV NNP cord-302530-pp6bl941 580 1 gp120 gp120 NNP cord-302530-pp6bl941 580 2 : : : cord-302530-pp6bl941 581 1 CD4 CD4 NNP cord-302530-pp6bl941 581 2 binding binding NN cord-302530-pp6bl941 581 3 is be VBZ cord-302530-pp6bl941 581 4 well well RB cord-302530-pp6bl941 581 5 documented document VBN cord-302530-pp6bl941 581 6 unlike unlike IN cord-302530-pp6bl941 581 7 that that DT cord-302530-pp6bl941 581 8 for for IN cord-302530-pp6bl941 581 9 arbovirus arbovirus NN cord-302530-pp6bl941 581 10 binding binding NN cord-302530-pp6bl941 581 11 and and CC cord-302530-pp6bl941 581 12 the the DT cord-302530-pp6bl941 581 13 values value NNS cord-302530-pp6bl941 581 14 of of IN cord-302530-pp6bl941 581 15 ΔH ΔH NNP cord-302530-pp6bl941 581 16 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 581 17 have have VBP cord-302530-pp6bl941 581 18 been be VBN cord-302530-pp6bl941 581 19 reported report VBN cord-302530-pp6bl941 581 20 over over IN cord-302530-pp6bl941 581 21 the the DT cord-302530-pp6bl941 581 22 temperature temperature NN cord-302530-pp6bl941 581 23 range range NN cord-302530-pp6bl941 581 24 of of IN cord-302530-pp6bl941 581 25 12 12 CD cord-302530-pp6bl941 581 26 ° ° NN cord-302530-pp6bl941 581 27 C c NN cord-302530-pp6bl941 581 28 to to IN cord-302530-pp6bl941 581 29 44 44 CD cord-302530-pp6bl941 581 30 ° ° NN cord-302530-pp6bl941 581 31 C c NN cord-302530-pp6bl941 581 32 ( ( -LRB- cord-302530-pp6bl941 581 33 Fig Fig NNP cord-302530-pp6bl941 581 34 . . . cord-302530-pp6bl941 581 35 1 1 CD cord-302530-pp6bl941 581 36 ) ) -RRB- cord-302530-pp6bl941 581 37 . . . cord-302530-pp6bl941 582 1 The the DT cord-302530-pp6bl941 582 2 results result NNS cord-302530-pp6bl941 582 3 with with IN cord-302530-pp6bl941 582 4 varying vary VBG cord-302530-pp6bl941 582 5 ΔC ΔC NNP cord-302530-pp6bl941 582 6 p p NN cord-302530-pp6bl941 582 7 in in IN cord-302530-pp6bl941 582 8 Fig Fig NNP cord-302530-pp6bl941 582 9 . . . cord-302530-pp6bl941 583 1 4 4 CD cord-302530-pp6bl941 583 2 are be VBP cord-302530-pp6bl941 583 3 therefore therefore RB cord-302530-pp6bl941 583 4 hypothetical hypothetical JJ cord-302530-pp6bl941 583 5 but but CC cord-302530-pp6bl941 583 6 illustrate illustrate VBP cord-302530-pp6bl941 583 7 how how WRB cord-302530-pp6bl941 583 8 the the DT cord-302530-pp6bl941 583 9 large large JJ cord-302530-pp6bl941 583 10 negative negative JJ cord-302530-pp6bl941 583 11 ΔC ΔC NNP cord-302530-pp6bl941 583 12 p p NN cord-302530-pp6bl941 583 13 for for IN cord-302530-pp6bl941 583 14 the the DT cord-302530-pp6bl941 583 15 HIV HIV NNP cord-302530-pp6bl941 583 16 Env Env NNP cord-302530-pp6bl941 583 17 : : : cord-302530-pp6bl941 583 18 CD4 CD4 NNP cord-302530-pp6bl941 583 19 interaction interaction NN cord-302530-pp6bl941 583 20 diminishes diminish VBZ cord-302530-pp6bl941 583 21 binding bind VBG cord-302530-pp6bl941 583 22 at at IN cord-302530-pp6bl941 583 23 the the DT cord-302530-pp6bl941 583 24 higher high JJR cord-302530-pp6bl941 583 25 temperatures temperature NNS cord-302530-pp6bl941 583 26 of of IN cord-302530-pp6bl941 583 27 mammals mammal NNS cord-302530-pp6bl941 583 28 and and CC cord-302530-pp6bl941 583 29 birds bird NNS cord-302530-pp6bl941 583 30 compared compare VBN cord-302530-pp6bl941 583 31 to to IN cord-302530-pp6bl941 583 32 a a DT cord-302530-pp6bl941 583 33 system system NN cord-302530-pp6bl941 583 34 such such JJ cord-302530-pp6bl941 583 35 as as IN cord-302530-pp6bl941 583 36 HA HA NNP cord-302530-pp6bl941 583 37 / / SYM cord-302530-pp6bl941 583 38 SA SA NNP cord-302530-pp6bl941 583 39 for for IN cord-302530-pp6bl941 583 40 which which WDT cord-302530-pp6bl941 583 41 ΔC δc NN cord-302530-pp6bl941 583 42 p p NN cord-302530-pp6bl941 583 43 = = SYM cord-302530-pp6bl941 583 44 0 0 CD cord-302530-pp6bl941 583 45 kJ kJ NNP cord-302530-pp6bl941 583 46 / / SYM cord-302530-pp6bl941 583 47 mol/ mol/ NNP cord-302530-pp6bl941 584 1 K. K. NNP cord-302530-pp6bl941 584 2 Thus thus RB cord-302530-pp6bl941 584 3 , , , cord-302530-pp6bl941 584 4 a a DT cord-302530-pp6bl941 584 5 less less RBR cord-302530-pp6bl941 584 6 negative negative JJ cord-302530-pp6bl941 584 7 ΔC δc NN cord-302530-pp6bl941 584 8 p p NN cord-302530-pp6bl941 584 9 increases increase VBZ cord-302530-pp6bl941 584 10 the the DT cord-302530-pp6bl941 584 11 number number NN cord-302530-pp6bl941 584 12 of of IN cord-302530-pp6bl941 584 13 cells cell NNS cord-302530-pp6bl941 584 14 with with IN cord-302530-pp6bl941 584 15 bound bind VBN cord-302530-pp6bl941 584 16 virus virus NN cord-302530-pp6bl941 584 17 at at IN cord-302530-pp6bl941 584 18 higher high JJR cord-302530-pp6bl941 584 19 temperatures temperature NNS cord-302530-pp6bl941 584 20 , , , cord-302530-pp6bl941 584 21 albeit albeit IN cord-302530-pp6bl941 584 22 more more RBR cord-302530-pp6bl941 584 23 markedly markedly RB cord-302530-pp6bl941 584 24 for for IN cord-302530-pp6bl941 584 25 the the DT cord-302530-pp6bl941 584 26 reference reference NN cord-302530-pp6bl941 584 27 temperature temperature NN cord-302530-pp6bl941 585 1 T t NN cord-302530-pp6bl941 585 2 0 0 CD cord-302530-pp6bl941 585 3 = = NFP cord-302530-pp6bl941 586 1 4 4 LS cord-302530-pp6bl941 586 2 ° ° NN cord-302530-pp6bl941 586 3 C C NNP cord-302530-pp6bl941 586 4 ( ( -LRB- cord-302530-pp6bl941 586 5 Fig Fig NNP cord-302530-pp6bl941 586 6 . . . cord-302530-pp6bl941 586 7 4d 4d CD cord-302530-pp6bl941 586 8 ) ) -RRB- cord-302530-pp6bl941 587 1 than than IN cord-302530-pp6bl941 587 2 for for IN cord-302530-pp6bl941 587 3 T t NN cord-302530-pp6bl941 587 4 0 0 CD cord-302530-pp6bl941 587 5 = = NFP cord-302530-pp6bl941 588 1 37 37 CD cord-302530-pp6bl941 588 2 ° ° NN cord-302530-pp6bl941 588 3 C c NN cord-302530-pp6bl941 588 4 ( ( -LRB- cord-302530-pp6bl941 588 5 Fig Fig NNP cord-302530-pp6bl941 588 6 . . . cord-302530-pp6bl941 588 7 4b 4b CD cord-302530-pp6bl941 588 8 ) ) -RRB- cord-302530-pp6bl941 588 9 . . . cord-302530-pp6bl941 589 1 In in IN cord-302530-pp6bl941 589 2 the the DT cord-302530-pp6bl941 589 3 absence absence NN cord-302530-pp6bl941 589 4 of of IN cord-302530-pp6bl941 589 5 data datum NNS cord-302530-pp6bl941 589 6 for for IN cord-302530-pp6bl941 589 7 ΔC ΔC NNP cord-302530-pp6bl941 589 8 p p NNP cord-302530-pp6bl941 589 9 for for IN cord-302530-pp6bl941 589 10 HIV HIV NNP cord-302530-pp6bl941 589 11 Env Env NNP cord-302530-pp6bl941 589 12 : : : cord-302530-pp6bl941 589 13 CD4 CD4 NNP cord-302530-pp6bl941 589 14 binding bind VBG cord-302530-pp6bl941 589 15 , , , cord-302530-pp6bl941 589 16 the the DT cord-302530-pp6bl941 589 17 value value NN cord-302530-pp6bl941 589 18 for for IN cord-302530-pp6bl941 589 19 the the DT cord-302530-pp6bl941 589 20 gp120 gp120 NNP cord-302530-pp6bl941 589 21 monomer monomer NN cord-302530-pp6bl941 589 22 : : : cord-302530-pp6bl941 590 1 CD4 CD4 NNP cord-302530-pp6bl941 590 2 interaction interaction NN cord-302530-pp6bl941 590 3 is be VBZ cord-302530-pp6bl941 590 4 used use VBN cord-302530-pp6bl941 590 5 for for IN cord-302530-pp6bl941 590 6 the the DT cord-302530-pp6bl941 590 7 HIV HIV NNP cord-302530-pp6bl941 590 8 models model NNS cord-302530-pp6bl941 590 9 in in IN cord-302530-pp6bl941 590 10 Figs Figs NNP cord-302530-pp6bl941 590 11 . . . cord-302530-pp6bl941 591 1 4 4 LS cord-302530-pp6bl941 591 2 - - SYM cord-302530-pp6bl941 591 3 6 6 CD cord-302530-pp6bl941 591 4 . . . cord-302530-pp6bl941 592 1 Evidence evidence NN cord-302530-pp6bl941 592 2 for for IN cord-302530-pp6bl941 592 3 a a DT cord-302530-pp6bl941 592 4 large large JJ cord-302530-pp6bl941 592 5 negative negative JJ cord-302530-pp6bl941 592 6 ΔC ΔC NNP cord-302530-pp6bl941 592 7 p p NN cord-302530-pp6bl941 592 8 for for IN cord-302530-pp6bl941 592 9 HIV HIV NNP cord-302530-pp6bl941 592 10 Env Env NNP cord-302530-pp6bl941 592 11 : : : cord-302530-pp6bl941 593 1 CD4 CD4 NNP cord-302530-pp6bl941 593 2 binding bind VBG cord-302530-pp6bl941 593 3 is be VBZ cord-302530-pp6bl941 593 4 that that IN cord-302530-pp6bl941 593 5 cryo cryo NN cord-302530-pp6bl941 593 6 - - HYPH cord-302530-pp6bl941 593 7 EM EM NNP cord-302530-pp6bl941 593 8 demonstrates demonstrate VBZ cord-302530-pp6bl941 593 9 considerable considerable JJ cord-302530-pp6bl941 593 10 conformational conformational JJ cord-302530-pp6bl941 593 11 shifts shift NNS cord-302530-pp6bl941 593 12 ( ( -LRB- cord-302530-pp6bl941 593 13 Liu Liu NNP cord-302530-pp6bl941 593 14 et et NNP cord-302530-pp6bl941 593 15 al al NNP cord-302530-pp6bl941 593 16 . . NNP cord-302530-pp6bl941 593 17 , , , cord-302530-pp6bl941 593 18 2017a 2017a CD cord-302530-pp6bl941 593 19 ) ) -RRB- cord-302530-pp6bl941 593 20 . . . cord-302530-pp6bl941 594 1 A a DT cord-302530-pp6bl941 594 2 negative negative JJ cord-302530-pp6bl941 594 3 value value NN cord-302530-pp6bl941 594 4 of of IN cord-302530-pp6bl941 594 5 ΔS ΔS NNP cord-302530-pp6bl941 594 6 a_immob a_immob NNP cord-302530-pp6bl941 594 7 presents present VBZ cord-302530-pp6bl941 594 8 a a DT cord-302530-pp6bl941 594 9 repulsive repulsive JJ cord-302530-pp6bl941 594 10 force force NN cord-302530-pp6bl941 594 11 between between IN cord-302530-pp6bl941 594 12 the the DT cord-302530-pp6bl941 594 13 virus virus NN cord-302530-pp6bl941 594 14 and and CC cord-302530-pp6bl941 594 15 the the DT cord-302530-pp6bl941 594 16 host host NN cord-302530-pp6bl941 594 17 cell cell NN cord-302530-pp6bl941 594 18 in in IN cord-302530-pp6bl941 594 19 effect effect NN cord-302530-pp6bl941 594 20 preventing prevent VBG cord-302530-pp6bl941 594 21 virus virus NN cord-302530-pp6bl941 594 22 binding bind VBG cord-302530-pp6bl941 594 23 and and CC cord-302530-pp6bl941 594 24 with with IN cord-302530-pp6bl941 594 25 n n NN cord-302530-pp6bl941 594 26 = = NN cord-302530-pp6bl941 594 27 0 0 CD cord-302530-pp6bl941 594 28 GP GP NNP cord-302530-pp6bl941 594 29 / / SYM cord-302530-pp6bl941 594 30 Cr cr NN cord-302530-pp6bl941 594 31 contacts contact NNS cord-302530-pp6bl941 594 32 , , , cord-302530-pp6bl941 594 33 K K NNP cord-302530-pp6bl941 594 34 a_virus_T a_virus_T NNP cord-302530-pp6bl941 594 35 is be VBZ cord-302530-pp6bl941 594 36 < < NNP cord-302530-pp6bl941 594 37 1 1 CD cord-302530-pp6bl941 594 38 M M NNP cord-302530-pp6bl941 594 39 − − NNP cord-302530-pp6bl941 594 40 1 1 CD cord-302530-pp6bl941 594 41 according accord VBG cord-302530-pp6bl941 594 42 to to IN cord-302530-pp6bl941 594 43 Eq Eq NNP cord-302530-pp6bl941 594 44 . . . cord-302530-pp6bl941 595 1 ( ( -LRB- cord-302530-pp6bl941 595 2 17 17 CD cord-302530-pp6bl941 595 3 ) ) -RRB- cord-302530-pp6bl941 596 1 ( ( -LRB- cord-302530-pp6bl941 596 2 Gale Gale NNP cord-302530-pp6bl941 596 3 2019 2019 CD cord-302530-pp6bl941 596 4 ) ) -RRB- cord-302530-pp6bl941 596 5 . . . cord-302530-pp6bl941 597 1 Increasing increase VBG cord-302530-pp6bl941 597 2 the the DT cord-302530-pp6bl941 597 3 value value NN cord-302530-pp6bl941 597 4 of of IN cord-302530-pp6bl941 597 5 n n NN cord-302530-pp6bl941 597 6 is be VBZ cord-302530-pp6bl941 597 7 one one CD cord-302530-pp6bl941 597 8 way way NN cord-302530-pp6bl941 597 9 for for IN cord-302530-pp6bl941 597 10 the the DT cord-302530-pp6bl941 597 11 virus virus NN cord-302530-pp6bl941 597 12 to to TO cord-302530-pp6bl941 597 13 overcome overcome VB cord-302530-pp6bl941 597 14 a a DT cord-302530-pp6bl941 597 15 large large JJ cord-302530-pp6bl941 597 16 negative negative JJ cord-302530-pp6bl941 597 17 value value NN cord-302530-pp6bl941 597 18 of of IN cord-302530-pp6bl941 597 19 ΔS ΔS NNP cord-302530-pp6bl941 597 20 a_immob a_immob NNP cord-302530-pp6bl941 597 21 ( ( -LRB- cord-302530-pp6bl941 597 22 Gale Gale NNP cord-302530-pp6bl941 597 23 2019 2019 CD cord-302530-pp6bl941 597 24 ) ) -RRB- cord-302530-pp6bl941 597 25 . . . cord-302530-pp6bl941 598 1 Thus thus RB cord-302530-pp6bl941 598 2 15 15 CD cord-302530-pp6bl941 598 3 to to TO cord-302530-pp6bl941 598 4 18 18 CD cord-302530-pp6bl941 598 5 GP GP NNP cord-302530-pp6bl941 598 6 / / SYM cord-302530-pp6bl941 598 7 Cr cr NN cord-302530-pp6bl941 598 8 contacts contact NNS cord-302530-pp6bl941 598 9 of of IN cord-302530-pp6bl941 598 10 K K NNP cord-302530-pp6bl941 598 11 d_receptor_T0 d_receptor_T0 NNP cord-302530-pp6bl941 598 12 = = SYM cord-302530-pp6bl941 598 13 10 10 CD cord-302530-pp6bl941 598 14 −3 −3 NN cord-302530-pp6bl941 598 15 M M NNP cord-302530-pp6bl941 598 16 ( ( -LRB- cord-302530-pp6bl941 598 17 37 37 CD cord-302530-pp6bl941 598 18 ° ° NN cord-302530-pp6bl941 598 19 C c NN cord-302530-pp6bl941 598 20 ) ) -RRB- cord-302530-pp6bl941 598 21 were be VBD cord-302530-pp6bl941 598 22 sufficient sufficient JJ cord-302530-pp6bl941 598 23 to to TO cord-302530-pp6bl941 598 24 overcome overcome VB cord-302530-pp6bl941 598 25 a a DT cord-302530-pp6bl941 598 26 ΔS ΔS NNP cord-302530-pp6bl941 598 27 a_immob a_immob NN cord-302530-pp6bl941 598 28 of of IN cord-302530-pp6bl941 598 29 −750 −750 NNP cord-302530-pp6bl941 598 30 J J NNP cord-302530-pp6bl941 598 31 / / SYM cord-302530-pp6bl941 598 32 mol mol NNP cord-302530-pp6bl941 598 33 / / SYM cord-302530-pp6bl941 598 34 K K NNP cord-302530-pp6bl941 598 35 such such JJ cord-302530-pp6bl941 598 36 that that IN cord-302530-pp6bl941 598 37 K K NNP cord-302530-pp6bl941 598 38 a_virus_T a_virus_T NNP cord-302530-pp6bl941 599 1 > > XX cord-302530-pp6bl941 600 1 10 10 CD cord-302530-pp6bl941 600 2 14 14 CD cord-302530-pp6bl941 600 3 M M NNP cord-302530-pp6bl941 600 4 − − NNP cord-302530-pp6bl941 600 5 1 1 CD cord-302530-pp6bl941 601 1 ( ( -LRB- cord-302530-pp6bl941 601 2 Fig Fig NNP cord-302530-pp6bl941 601 3 . . . cord-302530-pp6bl941 602 1 3 3 CD cord-302530-pp6bl941 602 2 of of IN cord-302530-pp6bl941 602 3 Gale Gale NNP cord-302530-pp6bl941 602 4 ( ( -LRB- cord-302530-pp6bl941 602 5 2019 2019 CD cord-302530-pp6bl941 602 6 ) ) -RRB- cord-302530-pp6bl941 602 7 ) ) -RRB- cord-302530-pp6bl941 602 8 . . . cord-302530-pp6bl941 603 1 This this DT cord-302530-pp6bl941 603 2 is be VBZ cord-302530-pp6bl941 603 3 apparent apparent JJ cord-302530-pp6bl941 603 4 from from IN cord-302530-pp6bl941 603 5 Fig Fig NNP cord-302530-pp6bl941 603 6 . . . cord-302530-pp6bl941 604 1 6a 6a LS cord-302530-pp6bl941 604 2 where where WRB cord-302530-pp6bl941 604 3 n n NN cord-302530-pp6bl941 604 4 = = SYM cord-302530-pp6bl941 604 5 3 3 CD cord-302530-pp6bl941 604 6 GP GP NNP cord-302530-pp6bl941 604 7 / / SYM cord-302530-pp6bl941 604 8 Cr cr NN cord-302530-pp6bl941 604 9 contacts contact NNS cord-302530-pp6bl941 604 10 can can MD cord-302530-pp6bl941 604 11 overcome overcome VB cord-302530-pp6bl941 604 12 a a DT cord-302530-pp6bl941 604 13 ΔS ΔS NNP cord-302530-pp6bl941 604 14 a_immob a_immob NN cord-302530-pp6bl941 604 15 of of IN cord-302530-pp6bl941 604 16 −206 −206 NNP cord-302530-pp6bl941 604 17 J J NNP cord-302530-pp6bl941 604 18 / / SYM cord-302530-pp6bl941 604 19 mol mol NNP cord-302530-pp6bl941 604 20 / / SYM cord-302530-pp6bl941 604 21 K K NNP cord-302530-pp6bl941 604 22 while while IN cord-302530-pp6bl941 604 23 n n NN cord-302530-pp6bl941 604 24 = = NN cord-302530-pp6bl941 604 25 9 9 CD cord-302530-pp6bl941 604 26 GP GP NNP cord-302530-pp6bl941 604 27 / / SYM cord-302530-pp6bl941 604 28 Cr cr NN cord-302530-pp6bl941 604 29 contacts contact NNS cord-302530-pp6bl941 604 30 are be VBP cord-302530-pp6bl941 604 31 required require VBN cord-302530-pp6bl941 604 32 to to TO cord-302530-pp6bl941 604 33 overcome overcome VB cord-302530-pp6bl941 604 34 the the DT cord-302530-pp6bl941 604 35 more more RBR cord-302530-pp6bl941 604 36 negative negative JJ cord-302530-pp6bl941 604 37 ΔS ΔS NNP cord-302530-pp6bl941 604 38 a_immob a_immob NNP cord-302530-pp6bl941 604 39 of of IN cord-302530-pp6bl941 604 40 −1110 −1110 NNP cord-302530-pp6bl941 604 41 J J NNP cord-302530-pp6bl941 604 42 / / SYM cord-302530-pp6bl941 604 43 mol mol NNP cord-302530-pp6bl941 604 44 / / SYM cord-302530-pp6bl941 604 45 K K NNP cord-302530-pp6bl941 604 46 in in IN cord-302530-pp6bl941 604 47 Fig Fig NNP cord-302530-pp6bl941 604 48 . . . cord-302530-pp6bl941 605 1 6b 6b CD cord-302530-pp6bl941 605 2 . . . cord-302530-pp6bl941 606 1 Even even RB cord-302530-pp6bl941 606 2 for for IN cord-302530-pp6bl941 606 3 ΔS ΔS NNP cord-302530-pp6bl941 606 4 a_immob a_immob NNP cord-302530-pp6bl941 606 5 = = SYM cord-302530-pp6bl941 606 6 0 0 NNP cord-302530-pp6bl941 606 7 J J NNP cord-302530-pp6bl941 606 8 / / SYM cord-302530-pp6bl941 606 9 mol mol NNP cord-302530-pp6bl941 606 10 / / SYM cord-302530-pp6bl941 606 11 K K NNP cord-302530-pp6bl941 606 12 as as IN cord-302530-pp6bl941 606 13 in in IN cord-302530-pp6bl941 606 14 Figs Figs NNPS cord-302530-pp6bl941 606 15 . . . cord-302530-pp6bl941 607 1 2a 2a NNP cord-302530-pp6bl941 607 2 and and CC cord-302530-pp6bl941 607 3 3a 3a NNP cord-302530-pp6bl941 607 4 , , , cord-302530-pp6bl941 607 5 the the DT cord-302530-pp6bl941 607 6 magnitude magnitude NN cord-302530-pp6bl941 607 7 of of IN cord-302530-pp6bl941 607 8 K K NNP cord-302530-pp6bl941 607 9 a_virus_T a_virus_T NNP cord-302530-pp6bl941 607 10 decreases decrease VBZ cord-302530-pp6bl941 607 11 with with IN cord-302530-pp6bl941 607 12 increasing increase VBG cord-302530-pp6bl941 607 13 temperature temperature NN cord-302530-pp6bl941 607 14 ( ( -LRB- cord-302530-pp6bl941 607 15 albeit albeit IN cord-302530-pp6bl941 607 16 after after IN cord-302530-pp6bl941 607 17 a a DT cord-302530-pp6bl941 607 18 peak peak NN cord-302530-pp6bl941 607 19 in in IN cord-302530-pp6bl941 607 20 the the DT cord-302530-pp6bl941 607 21 case case NN cord-302530-pp6bl941 607 22 of of IN cord-302530-pp6bl941 607 23 ΔC ΔC NNP cord-302530-pp6bl941 607 24 p p XX cord-302530-pp6bl941 607 25 < < XX cord-302530-pp6bl941 607 26 −2.0 −2.0 CD cord-302530-pp6bl941 607 27 kJ kJ NNP cord-302530-pp6bl941 607 28 / / SYM cord-302530-pp6bl941 607 29 mol mol NNP cord-302530-pp6bl941 607 30 / / SYM cord-302530-pp6bl941 607 31 K K NNP cord-302530-pp6bl941 607 32 ) ) -RRB- cord-302530-pp6bl941 607 33 . . . cord-302530-pp6bl941 608 1 This this DT cord-302530-pp6bl941 608 2 is be VBZ cord-302530-pp6bl941 608 3 due due JJ cord-302530-pp6bl941 608 4 to to IN cord-302530-pp6bl941 608 5 the the DT cord-302530-pp6bl941 608 6 reduced reduce VBN cord-302530-pp6bl941 608 7 affinity affinity NN cord-302530-pp6bl941 608 8 of of IN cord-302530-pp6bl941 608 9 the the DT cord-302530-pp6bl941 608 10 enthalpy enthalpy NN cord-302530-pp6bl941 608 11 - - HYPH cord-302530-pp6bl941 608 12 driven drive VBN cord-302530-pp6bl941 608 13 GP GP NNP cord-302530-pp6bl941 608 14 / / SYM cord-302530-pp6bl941 608 15 Cr cr NN cord-302530-pp6bl941 608 16 interactions interaction NNS cord-302530-pp6bl941 608 17 at at IN cord-302530-pp6bl941 608 18 higher high JJR cord-302530-pp6bl941 608 19 temperatures temperature NNS cord-302530-pp6bl941 608 20 . . . cord-302530-pp6bl941 609 1 Making make VBG cord-302530-pp6bl941 609 2 ΔS ΔS NNP cord-302530-pp6bl941 609 3 a_immob a_immob NNP cord-302530-pp6bl941 609 4 more more RBR cord-302530-pp6bl941 609 5 negative negative JJ cord-302530-pp6bl941 609 6 shifts shift NNS cord-302530-pp6bl941 609 7 the the DT cord-302530-pp6bl941 609 8 K K NNP cord-302530-pp6bl941 609 9 a_virus_T a_virus_T NNP cord-302530-pp6bl941 609 10 curve curve NN cord-302530-pp6bl941 609 11 to to IN cord-302530-pp6bl941 609 12 lower low JJR cord-302530-pp6bl941 609 13 values value NNS cord-302530-pp6bl941 609 14 ( ( -LRB- cord-302530-pp6bl941 609 15 Fig fig NN cord-302530-pp6bl941 609 16 . . . cord-302530-pp6bl941 609 17 5a 5a CD cord-302530-pp6bl941 609 18 ) ) -RRB- cord-302530-pp6bl941 610 1 thus thus RB cord-302530-pp6bl941 610 2 exacerbating exacerbate VBG cord-302530-pp6bl941 610 3 the the DT cord-302530-pp6bl941 610 4 effect effect NN cord-302530-pp6bl941 610 5 of of IN cord-302530-pp6bl941 610 6 higher high JJR cord-302530-pp6bl941 610 7 temperature temperature NN cord-302530-pp6bl941 610 8 on on IN cord-302530-pp6bl941 610 9 reducing reduce VBG cord-302530-pp6bl941 610 10 binding binding NN cord-302530-pp6bl941 610 11 . . . cord-302530-pp6bl941 611 1 As as IN cord-302530-pp6bl941 611 2 K K NNP cord-302530-pp6bl941 611 3 a_virus_T a_virus_T NNP cord-302530-pp6bl941 611 4 falls fall VBZ cord-302530-pp6bl941 611 5 below below IN cord-302530-pp6bl941 611 6 10 10 CD cord-302530-pp6bl941 611 7 14 14 CD cord-302530-pp6bl941 611 8 M M NNP cord-302530-pp6bl941 611 9 − − NNP cord-302530-pp6bl941 611 10 1 1 CD cord-302530-pp6bl941 611 11 at at IN cord-302530-pp6bl941 611 12 higher high JJR cord-302530-pp6bl941 611 13 temperatures temperature NNS cord-302530-pp6bl941 611 14 , , , cord-302530-pp6bl941 611 15 so so RB cord-302530-pp6bl941 611 16 C.V C.V NNP cord-302530-pp6bl941 611 17 T T NNP cord-302530-pp6bl941 611 18 falls fall VBZ cord-302530-pp6bl941 611 19 ( ( -LRB- cord-302530-pp6bl941 611 20 Fig Fig NNP cord-302530-pp6bl941 611 21 . . . cord-302530-pp6bl941 611 22 5b 5b CD cord-302530-pp6bl941 611 23 ) ) -RRB- cord-302530-pp6bl941 611 24 . . . cord-302530-pp6bl941 612 1 The the DT cord-302530-pp6bl941 612 2 magnitude magnitude NN cord-302530-pp6bl941 612 3 of of IN cord-302530-pp6bl941 612 4 ΔS ΔS NNP cord-302530-pp6bl941 612 5 a_immob a_immob NNP cord-302530-pp6bl941 612 6 merely merely RB cord-302530-pp6bl941 612 7 positions position VBZ cord-302530-pp6bl941 612 8 the the DT cord-302530-pp6bl941 612 9 C.V C.V NNP cord-302530-pp6bl941 612 10 T T NNP cord-302530-pp6bl941 612 11 curve curve NN cord-302530-pp6bl941 612 12 relative relative JJ cord-302530-pp6bl941 612 13 to to IN cord-302530-pp6bl941 612 14 the the DT cord-302530-pp6bl941 612 15 temperature temperature NN cord-302530-pp6bl941 612 16 scale scale NN cord-302530-pp6bl941 612 17 with with IN cord-302530-pp6bl941 612 18 less less JJR cord-302530-pp6bl941 612 19 negative negative JJ cord-302530-pp6bl941 612 20 values value NNS cord-302530-pp6bl941 612 21 of of IN cord-302530-pp6bl941 612 22 ΔS ΔS NNP cord-302530-pp6bl941 612 23 a_immob a_immob NNP cord-302530-pp6bl941 612 24 shifting shift VBG cord-302530-pp6bl941 612 25 the the DT cord-302530-pp6bl941 612 26 curve curve NN cord-302530-pp6bl941 612 27 to to IN cord-302530-pp6bl941 612 28 higher high JJR cord-302530-pp6bl941 612 29 temperatures temperature NNS cord-302530-pp6bl941 612 30 ( ( -LRB- cord-302530-pp6bl941 612 31 Fig fig NN cord-302530-pp6bl941 612 32 . . . cord-302530-pp6bl941 612 33 5b 5b CD cord-302530-pp6bl941 612 34 ) ) -RRB- cord-302530-pp6bl941 612 35 such such JJ cord-302530-pp6bl941 612 36 that that IN cord-302530-pp6bl941 612 37 high high JJ cord-302530-pp6bl941 612 38 C.V c.v NN cord-302530-pp6bl941 612 39 T t NN cord-302530-pp6bl941 612 40 values value NNS cord-302530-pp6bl941 612 41 are be VBP cord-302530-pp6bl941 612 42 maintained maintain VBN cord-302530-pp6bl941 612 43 at at IN cord-302530-pp6bl941 612 44 progressively progressively RB cord-302530-pp6bl941 612 45 higher high JJR cord-302530-pp6bl941 612 46 temperatures temperature NNS cord-302530-pp6bl941 612 47 as as IN cord-302530-pp6bl941 612 48 ΔS ΔS NNP cord-302530-pp6bl941 612 49 a_immob a_immob NNP cord-302530-pp6bl941 612 50 becomes become VBZ cord-302530-pp6bl941 612 51 less less RBR cord-302530-pp6bl941 612 52 negative negative JJ cord-302530-pp6bl941 612 53 ( ( -LRB- cord-302530-pp6bl941 612 54 Fig Fig NNP cord-302530-pp6bl941 612 55 . . . cord-302530-pp6bl941 612 56 5c 5c CD cord-302530-pp6bl941 612 57 ) ) -RRB- cord-302530-pp6bl941 612 58 . . . cord-302530-pp6bl941 613 1 The the DT cord-302530-pp6bl941 613 2 thermodynamic thermodynamic JJ cord-302530-pp6bl941 613 3 model model NN cord-302530-pp6bl941 613 4 here here RB cord-302530-pp6bl941 613 5 suggests suggest VBZ cord-302530-pp6bl941 613 6 that that IN cord-302530-pp6bl941 613 7 a a DT cord-302530-pp6bl941 613 8 large large JJ cord-302530-pp6bl941 613 9 negative negative JJ cord-302530-pp6bl941 613 10 ΔC ΔC NNP cord-302530-pp6bl941 613 11 p p NN cord-302530-pp6bl941 613 12 for for IN cord-302530-pp6bl941 613 13 HIV HIV NNP cord-302530-pp6bl941 613 14 Env Env NNP cord-302530-pp6bl941 613 15 : : : cord-302530-pp6bl941 613 16 CD4 CD4 NNP cord-302530-pp6bl941 613 17 diminishes diminish VBZ cord-302530-pp6bl941 613 18 binding bind VBG cord-302530-pp6bl941 613 19 at at IN cord-302530-pp6bl941 613 20 higher high JJR cord-302530-pp6bl941 613 21 temperatures temperature NNS cord-302530-pp6bl941 613 22 . . . cord-302530-pp6bl941 614 1 However however RB cord-302530-pp6bl941 614 2 , , , cord-302530-pp6bl941 614 3 there there EX cord-302530-pp6bl941 614 4 may may MD cord-302530-pp6bl941 614 5 be be VB cord-302530-pp6bl941 614 6 molecular molecular JJ cord-302530-pp6bl941 614 7 constraints constraint NNS cord-302530-pp6bl941 614 8 such such JJ cord-302530-pp6bl941 614 9 that that IN cord-302530-pp6bl941 614 10 a a DT cord-302530-pp6bl941 614 11 large large JJ cord-302530-pp6bl941 614 12 negative negative JJ cord-302530-pp6bl941 614 13 ΔC δc NN cord-302530-pp6bl941 614 14 p p NN cord-302530-pp6bl941 614 15 value value NN cord-302530-pp6bl941 614 16 is be VBZ cord-302530-pp6bl941 614 17 a a DT cord-302530-pp6bl941 614 18 direct direct JJ cord-302530-pp6bl941 614 19 consequence consequence NN cord-302530-pp6bl941 614 20 of of IN cord-302530-pp6bl941 614 21 a a DT cord-302530-pp6bl941 614 22 molecular molecular JJ cord-302530-pp6bl941 614 23 mechanism mechanism NN cord-302530-pp6bl941 614 24 involving involve VBG cord-302530-pp6bl941 614 25 a a DT cord-302530-pp6bl941 614 26 large large JJ cord-302530-pp6bl941 614 27 conformational conformational JJ cord-302530-pp6bl941 614 28 change change NN cord-302530-pp6bl941 614 29 that that WDT cord-302530-pp6bl941 614 30 serves serve VBZ cord-302530-pp6bl941 614 31 a a DT cord-302530-pp6bl941 614 32 purpose purpose NN cord-302530-pp6bl941 614 33 for for IN cord-302530-pp6bl941 614 34 cell cell NN cord-302530-pp6bl941 614 35 entry entry NN cord-302530-pp6bl941 614 36 / / SYM cord-302530-pp6bl941 614 37 fusion fusion NN cord-302530-pp6bl941 614 38 ( ( -LRB- cord-302530-pp6bl941 614 39 Harrison Harrison NNP cord-302530-pp6bl941 614 40 2015 2015 CD cord-302530-pp6bl941 614 41 ) ) -RRB- cord-302530-pp6bl941 614 42 such such JJ cord-302530-pp6bl941 614 43 that that IN cord-302530-pp6bl941 614 44 a a DT cord-302530-pp6bl941 614 45 negligible negligible JJ cord-302530-pp6bl941 614 46 ΔC δc NN cord-302530-pp6bl941 614 47 p p NN cord-302530-pp6bl941 614 48 value value NN cord-302530-pp6bl941 614 49 may may MD cord-302530-pp6bl941 614 50 not not RB cord-302530-pp6bl941 614 51 be be VB cord-302530-pp6bl941 614 52 achievable achievable JJ cord-302530-pp6bl941 614 53 . . . cord-302530-pp6bl941 615 1 Furthermore furthermore RB cord-302530-pp6bl941 615 2 , , , cord-302530-pp6bl941 615 3 a a DT cord-302530-pp6bl941 615 4 large large JJ cord-302530-pp6bl941 615 5 negative negative JJ cord-302530-pp6bl941 615 6 ΔS ΔS NNP cord-302530-pp6bl941 615 7 a_immob a_immob NNP cord-302530-pp6bl941 615 8 imposes impose VBZ cord-302530-pp6bl941 615 9 additional additional JJ cord-302530-pp6bl941 615 10 constraints constraint NNS cord-302530-pp6bl941 615 11 on on IN cord-302530-pp6bl941 615 12 virus virus NN cord-302530-pp6bl941 615 13 binding bind VBG cord-302530-pp6bl941 615 14 at at IN cord-302530-pp6bl941 615 15 higher high JJR cord-302530-pp6bl941 615 16 temperatures temperature NNS cord-302530-pp6bl941 615 17 exacerbating exacerbate VBG cord-302530-pp6bl941 615 18 the the DT cord-302530-pp6bl941 615 19 reduced reduce VBN cord-302530-pp6bl941 615 20 strength strength NN cord-302530-pp6bl941 615 21 of of IN cord-302530-pp6bl941 615 22 the the DT cord-302530-pp6bl941 615 23 enthalpy enthalpy NN cord-302530-pp6bl941 615 24 - - HYPH cord-302530-pp6bl941 615 25 driven drive VBN cord-302530-pp6bl941 615 26 GP GP NNP cord-302530-pp6bl941 615 27 / / SYM cord-302530-pp6bl941 615 28 Cr cr NN cord-302530-pp6bl941 615 29 interactions interaction NNS cord-302530-pp6bl941 615 30 at at IN cord-302530-pp6bl941 615 31 higher high JJR cord-302530-pp6bl941 615 32 temperatures temperature NNS cord-302530-pp6bl941 615 33 . . . cord-302530-pp6bl941 616 1 Therefore therefore RB cord-302530-pp6bl941 616 2 other other JJ cord-302530-pp6bl941 616 3 mechanisms mechanism NNS cord-302530-pp6bl941 616 4 may may MD cord-302530-pp6bl941 616 5 be be VB cord-302530-pp6bl941 616 6 needed need VBN cord-302530-pp6bl941 616 7 by by IN cord-302530-pp6bl941 616 8 the the DT cord-302530-pp6bl941 616 9 virus virus NN cord-302530-pp6bl941 616 10 to to TO cord-302530-pp6bl941 616 11 achieve achieve VB cord-302530-pp6bl941 616 12 binding bind VBG cord-302530-pp6bl941 616 13 at at IN cord-302530-pp6bl941 616 14 37 37 CD cord-302530-pp6bl941 616 15 ° ° NN cord-302530-pp6bl941 616 16 C c NN cord-302530-pp6bl941 616 17 . . . cord-302530-pp6bl941 617 1 These these DT cord-302530-pp6bl941 617 2 could could MD cord-302530-pp6bl941 617 3 include include VB cord-302530-pp6bl941 617 4 more more JJR cord-302530-pp6bl941 617 5 GP GP NNP cord-302530-pp6bl941 617 6 / / SYM cord-302530-pp6bl941 617 7 Cr cr NN cord-302530-pp6bl941 617 8 contacts contact NNS cord-302530-pp6bl941 617 9 at at IN cord-302530-pp6bl941 617 10 higher high JJR cord-302530-pp6bl941 617 11 temperature temperature NN cord-302530-pp6bl941 617 12 ( ( -LRB- cord-302530-pp6bl941 617 13 Frey Frey NNP cord-302530-pp6bl941 617 14 et et NNP cord-302530-pp6bl941 617 15 al al NNP cord-302530-pp6bl941 617 16 . . NNP cord-302530-pp6bl941 617 17 , , , cord-302530-pp6bl941 617 18 1995 1995 CD cord-302530-pp6bl941 617 19 ; ; : cord-302530-pp6bl941 617 20 Harada Harada NNP cord-302530-pp6bl941 617 21 et et NNP cord-302530-pp6bl941 617 22 al al NNP cord-302530-pp6bl941 617 23 . . NNP cord-302530-pp6bl941 617 24 , , , cord-302530-pp6bl941 617 25 2004 2004 CD cord-302530-pp6bl941 617 26 ) ) -RRB- cord-302530-pp6bl941 617 27 . . . cord-302530-pp6bl941 618 1 An an DT cord-302530-pp6bl941 618 2 alternative alternative JJ cord-302530-pp6bl941 618 3 strategy strategy NN cord-302530-pp6bl941 618 4 evolved evolve VBN cord-302530-pp6bl941 618 5 by by IN cord-302530-pp6bl941 618 6 viruses virus NNS cord-302530-pp6bl941 618 7 could could MD cord-302530-pp6bl941 618 8 be be VB cord-302530-pp6bl941 618 9 to to TO cord-302530-pp6bl941 618 10 make make VB cord-302530-pp6bl941 618 11 ΔS ΔS NNP cord-302530-pp6bl941 618 12 a_immob a_immob NNP cord-302530-pp6bl941 618 13 itself -PRON- PRP cord-302530-pp6bl941 618 14 less less RBR cord-302530-pp6bl941 618 15 negative negative JJ cord-302530-pp6bl941 618 16 such such JJ cord-302530-pp6bl941 618 17 that that IN cord-302530-pp6bl941 618 18 virus virus NN cord-302530-pp6bl941 618 19 binding binding NN cord-302530-pp6bl941 618 20 is be VBZ cord-302530-pp6bl941 618 21 maintained maintain VBN cord-302530-pp6bl941 618 22 at at IN cord-302530-pp6bl941 618 23 the the DT cord-302530-pp6bl941 618 24 higher high JJR cord-302530-pp6bl941 618 25 body body NN cord-302530-pp6bl941 618 26 temperatures temperature NNS cord-302530-pp6bl941 618 27 of of IN cord-302530-pp6bl941 618 28 mammals mammal NNS cord-302530-pp6bl941 618 29 and and CC cord-302530-pp6bl941 618 30 birds bird NNS cord-302530-pp6bl941 618 31 . . . cord-302530-pp6bl941 619 1 Two two CD cord-302530-pp6bl941 619 2 possible possible JJ cord-302530-pp6bl941 619 3 evolutionary evolutionary JJ cord-302530-pp6bl941 619 4 strategies strategy NNS cord-302530-pp6bl941 619 5 are be VBP cord-302530-pp6bl941 619 6 suggested suggest VBN cord-302530-pp6bl941 619 7 here here RB cord-302530-pp6bl941 619 8 which which WDT cord-302530-pp6bl941 619 9 could could MD cord-302530-pp6bl941 619 10 make make VB cord-302530-pp6bl941 619 11 ΔS ΔS NNP cord-302530-pp6bl941 619 12 a_immob a_immob NNP cord-302530-pp6bl941 619 13 less less RBR cord-302530-pp6bl941 619 14 negative negative JJ cord-302530-pp6bl941 619 15 . . . cord-302530-pp6bl941 620 1 The the DT cord-302530-pp6bl941 620 2 first first JJ cord-302530-pp6bl941 620 3 is be VBZ cord-302530-pp6bl941 620 4 decreasing decrease VBG cord-302530-pp6bl941 620 5 the the DT cord-302530-pp6bl941 620 6 size size NN cord-302530-pp6bl941 620 7 of of IN cord-302530-pp6bl941 620 8 the the DT cord-302530-pp6bl941 620 9 virus virus NN cord-302530-pp6bl941 620 10 and and CC cord-302530-pp6bl941 620 11 the the DT cord-302530-pp6bl941 620 12 second second JJ cord-302530-pp6bl941 620 13 is be VBZ cord-302530-pp6bl941 620 14 the the DT cord-302530-pp6bl941 620 15 use use NN cord-302530-pp6bl941 620 16 of of IN cord-302530-pp6bl941 620 17 non- non- NNP cord-302530-pp6bl941 620 18 Fig Fig NNP cord-302530-pp6bl941 620 19 . . . cord-302530-pp6bl941 620 20 6 6 CD cord-302530-pp6bl941 620 21 . . . cord-302530-pp6bl941 621 1 Experimental experimental JJ cord-302530-pp6bl941 621 2 binding binding NN cord-302530-pp6bl941 621 3 of of IN cord-302530-pp6bl941 621 4 HIV HIV NNP cord-302530-pp6bl941 621 5 Env Env NNP cord-302530-pp6bl941 621 6 - - HYPH cord-302530-pp6bl941 621 7 expressing express VBG cord-302530-pp6bl941 621 8 cells cell NNS cord-302530-pp6bl941 621 9 to to IN cord-302530-pp6bl941 621 10 cells cell NNS cord-302530-pp6bl941 621 11 expressing express VBG cord-302530-pp6bl941 621 12 CD4 CD4 NNP cord-302530-pp6bl941 621 13 as as IN cord-302530-pp6bl941 621 14 reported report VBN cord-302530-pp6bl941 621 15 by by IN cord-302530-pp6bl941 621 16 Frey Frey NNP cord-302530-pp6bl941 621 17 et et NNP cord-302530-pp6bl941 621 18 al al NNP cord-302530-pp6bl941 621 19 . . . cord-302530-pp6bl941 622 1 ( ( -LRB- cord-302530-pp6bl941 622 2 1995 1995 CD cord-302530-pp6bl941 622 3 ) ) -RRB- cord-302530-pp6bl941 622 4 increases increase VBZ cord-302530-pp6bl941 622 5 three three CD cord-302530-pp6bl941 622 6 to to TO cord-302530-pp6bl941 622 7 four four CD cord-302530-pp6bl941 622 8 fold fold NN cord-302530-pp6bl941 622 9 at at IN cord-302530-pp6bl941 622 10 25 25 CD cord-302530-pp6bl941 622 11 ° ° NN cord-302530-pp6bl941 622 12 C C NNP cord-302530-pp6bl941 622 13 ( ( -LRB- cord-302530-pp6bl941 622 14 cross cross NN cord-302530-pp6bl941 622 15 ) ) -RRB- cord-302530-pp6bl941 622 16 . . . cord-302530-pp6bl941 623 1 The the DT cord-302530-pp6bl941 623 2 number number NN cord-302530-pp6bl941 623 3 , , , cord-302530-pp6bl941 623 4 C.V C.V NNP cord-302530-pp6bl941 623 5 T T NNP cord-302530-pp6bl941 623 6 , , , cord-302530-pp6bl941 623 7 of of IN cord-302530-pp6bl941 623 8 CD4 CD4 NNP cord-302530-pp6bl941 623 9 + + CC cord-302530-pp6bl941 623 10 T t NN cord-302530-pp6bl941 623 11 cells cell NNS cord-302530-pp6bl941 623 12 with with IN cord-302530-pp6bl941 623 13 bound bind VBN cord-302530-pp6bl941 623 14 HIV HIV NNP cord-302530-pp6bl941 623 15 virions virion NNS cord-302530-pp6bl941 623 16 per per IN cord-302530-pp6bl941 623 17 mm mm CD cord-302530-pp6bl941 623 18 3 3 CD cord-302530-pp6bl941 623 19 blood blood NN cord-302530-pp6bl941 623 20 predicted predict VBN cord-302530-pp6bl941 623 21 by by IN cord-302530-pp6bl941 623 22 the the DT cord-302530-pp6bl941 623 23 thermodynamic thermodynamic JJ cord-302530-pp6bl941 623 24 model model NN cord-302530-pp6bl941 623 25 ( ( -LRB- cord-302530-pp6bl941 623 26 circle circle NN cord-302530-pp6bl941 623 27 ) ) -RRB- cord-302530-pp6bl941 623 28 using use VBG cord-302530-pp6bl941 623 29 Eq Eq NNP cord-302530-pp6bl941 623 30 . . . cord-302530-pp6bl941 624 1 ( ( -LRB- cord-302530-pp6bl941 624 2 11 11 CD cord-302530-pp6bl941 624 3 ) ) -RRB- cord-302530-pp6bl941 624 4 with with IN cord-302530-pp6bl941 624 5 the the DT cord-302530-pp6bl941 624 6 number number NN cord-302530-pp6bl941 624 7 , , , cord-302530-pp6bl941 624 8 n n NN cord-302530-pp6bl941 624 9 , , , cord-302530-pp6bl941 624 10 of of IN cord-302530-pp6bl941 624 11 GP GP NNP cord-302530-pp6bl941 624 12 / / SYM cord-302530-pp6bl941 624 13 Cr cr NN cord-302530-pp6bl941 624 14 contacts contact NNS cord-302530-pp6bl941 624 15 increasing increase VBG cord-302530-pp6bl941 624 16 according accord VBG cord-302530-pp6bl941 624 17 to to IN cord-302530-pp6bl941 624 18 the the DT cord-302530-pp6bl941 624 19 dotted dotted JJ cord-302530-pp6bl941 624 20 line line NN cord-302530-pp6bl941 624 21 with with IN cord-302530-pp6bl941 624 22 temperature temperature NN cord-302530-pp6bl941 624 23 in in IN cord-302530-pp6bl941 624 24 a a DT cord-302530-pp6bl941 624 25 ) ) -RRB- cord-302530-pp6bl941 624 26 from from IN cord-302530-pp6bl941 624 27 1 1 CD cord-302530-pp6bl941 624 28 to to IN cord-302530-pp6bl941 624 29 3 3 CD cord-302530-pp6bl941 624 30 between between IN cord-302530-pp6bl941 624 31 25 25 CD cord-302530-pp6bl941 624 32 and and CC cord-302530-pp6bl941 624 33 27 27 CD cord-302530-pp6bl941 624 34 ° ° NN cord-302530-pp6bl941 624 35 C c NN cord-302530-pp6bl941 624 36 ; ; : cord-302530-pp6bl941 624 37 and and CC cord-302530-pp6bl941 624 38 in in IN cord-302530-pp6bl941 624 39 b b LS cord-302530-pp6bl941 624 40 ) ) -RRB- cord-302530-pp6bl941 624 41 from from IN cord-302530-pp6bl941 624 42 1 1 CD cord-302530-pp6bl941 624 43 to to IN cord-302530-pp6bl941 624 44 9 9 CD cord-302530-pp6bl941 624 45 between between IN cord-302530-pp6bl941 624 46 19 19 CD cord-302530-pp6bl941 624 47 ° ° NN cord-302530-pp6bl941 624 48 C c NN cord-302530-pp6bl941 624 49 and and CC cord-302530-pp6bl941 624 50 27 27 CD cord-302530-pp6bl941 624 51 ° ° NN cord-302530-pp6bl941 624 52 C c NN cord-302530-pp6bl941 624 53 . . . cord-302530-pp6bl941 625 1 The the DT cord-302530-pp6bl941 625 2 values value NNS cord-302530-pp6bl941 625 3 of of IN cord-302530-pp6bl941 625 4 ΔH ΔH NNP cord-302530-pp6bl941 625 5 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 625 6 and and CC cord-302530-pp6bl941 625 7 ΔS ΔS NNP cord-302530-pp6bl941 625 8 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 625 9 at at IN cord-302530-pp6bl941 625 10 T t NN cord-302530-pp6bl941 625 11 0 0 CD cord-302530-pp6bl941 625 12 = = NFP cord-302530-pp6bl941 626 1 37 37 CD cord-302530-pp6bl941 626 2 ° ° NN cord-302530-pp6bl941 626 3 C c NN cord-302530-pp6bl941 626 4 for for IN cord-302530-pp6bl941 626 5 non non JJ cord-302530-pp6bl941 626 6 - - JJ cord-302530-pp6bl941 626 7 specific specific JJ cord-302530-pp6bl941 626 8 attachment attachment NN cord-302530-pp6bl941 626 9 factor factor NN cord-302530-pp6bl941 626 10 binding binding NN cord-302530-pp6bl941 626 11 and and CC cord-302530-pp6bl941 626 12 for for IN cord-302530-pp6bl941 626 13 HIV HIV NNP cord-302530-pp6bl941 626 14 Env Env NNP cord-302530-pp6bl941 626 15 : : : cord-302530-pp6bl941 627 1 CCR5 ccr5 JJ cord-302530-pp6bl941 627 2 co co NN cord-302530-pp6bl941 627 3 - - NN cord-302530-pp6bl941 627 4 receptor receptor NN cord-302530-pp6bl941 627 5 binding binding NN cord-302530-pp6bl941 627 6 are be VBP cord-302530-pp6bl941 627 7 as as IN cord-302530-pp6bl941 627 8 those those DT cord-302530-pp6bl941 627 9 for for IN cord-302530-pp6bl941 627 10 specific specific JJ cord-302530-pp6bl941 627 11 HIV HIV NNP cord-302530-pp6bl941 627 12 Env Env NNP cord-302530-pp6bl941 627 13 : : : cord-302530-pp6bl941 628 1 CD4 CD4 NNP cord-302530-pp6bl941 628 2 binding bind VBG cord-302530-pp6bl941 628 3 in in IN cord-302530-pp6bl941 628 4 Table Table NNP cord-302530-pp6bl941 628 5 4 4 CD cord-302530-pp6bl941 628 6 with with IN cord-302530-pp6bl941 628 7 ΔC δc NN cord-302530-pp6bl941 628 8 p p NN cord-302530-pp6bl941 628 9 = = NN cord-302530-pp6bl941 628 10 −5.02 −5.02 NNP cord-302530-pp6bl941 628 11 kJ kJ NNP cord-302530-pp6bl941 628 12 / / SYM cord-302530-pp6bl941 628 13 mol mol NNP cord-302530-pp6bl941 628 14 / / SYM cord-302530-pp6bl941 628 15 K K NNP cord-302530-pp6bl941 628 16 ( ( -LRB- cord-302530-pp6bl941 628 17 Table Table NNP cord-302530-pp6bl941 628 18 3 3 CD cord-302530-pp6bl941 628 19 ) ) -RRB- cord-302530-pp6bl941 628 20 . . . cord-302530-pp6bl941 629 1 ΔS ΔS NNP cord-302530-pp6bl941 629 2 a_immob a_immob NNP cord-302530-pp6bl941 629 3 = = VBZ cord-302530-pp6bl941 629 4 a a NN cord-302530-pp6bl941 629 5 ) ) -RRB- cord-302530-pp6bl941 630 1 −206 −206 UH cord-302530-pp6bl941 630 2 J J NNP cord-302530-pp6bl941 630 3 / / SYM cord-302530-pp6bl941 630 4 mol mol NNP cord-302530-pp6bl941 630 5 / / SYM cord-302530-pp6bl941 630 6 K K NNP cord-302530-pp6bl941 630 7 to to TO cord-302530-pp6bl941 630 8 represent represent VB cord-302530-pp6bl941 630 9 prior prior JJ cord-302530-pp6bl941 630 10 elimination elimination NN cord-302530-pp6bl941 630 11 of of IN cord-302530-pp6bl941 630 12 ΔS ΔS NNP cord-302530-pp6bl941 630 13 a_non_specific a_non_specific NN cord-302530-pp6bl941 630 14 through through IN cord-302530-pp6bl941 630 15 binding binding NN cord-302530-pp6bl941 630 16 of of IN cord-302530-pp6bl941 630 17 virus virus NN cord-302530-pp6bl941 630 18 through through IN cord-302530-pp6bl941 630 19 nonspecific nonspecific JJ cord-302530-pp6bl941 630 20 attachment attachment NN cord-302530-pp6bl941 630 21 ; ; : cord-302530-pp6bl941 630 22 and and CC cord-302530-pp6bl941 630 23 b b LS cord-302530-pp6bl941 630 24 ) ) -RRB- cord-302530-pp6bl941 630 25 −1,110 −1,110 NNP cord-302530-pp6bl941 630 26 J J NNP cord-302530-pp6bl941 630 27 / / SYM cord-302530-pp6bl941 630 28 mol mol NNP cord-302530-pp6bl941 630 29 / / SYM cord-302530-pp6bl941 630 30 K K NNP cord-302530-pp6bl941 630 31 to to TO cord-302530-pp6bl941 630 32 represent represent VB cord-302530-pp6bl941 630 33 free free JJ cord-302530-pp6bl941 630 34 virus virus NN cord-302530-pp6bl941 630 35 binding bind VBG cord-302530-pp6bl941 630 36 . . . cord-302530-pp6bl941 631 1 specific specific JJ cord-302530-pp6bl941 631 2 attachment attachment NN cord-302530-pp6bl941 631 3 factors factor NNS cord-302530-pp6bl941 631 4 to to TO cord-302530-pp6bl941 631 5 randomly randomly RB cord-302530-pp6bl941 631 6 trap trap VB cord-302530-pp6bl941 631 7 the the DT cord-302530-pp6bl941 631 8 virus virus NN cord-302530-pp6bl941 631 9 on on IN cord-302530-pp6bl941 631 10 the the DT cord-302530-pp6bl941 631 11 cell cell NN cord-302530-pp6bl941 631 12 surface surface NN cord-302530-pp6bl941 631 13 prior prior RB cord-302530-pp6bl941 631 14 to to IN cord-302530-pp6bl941 631 15 specific specific JJ cord-302530-pp6bl941 631 16 GP GP NNP cord-302530-pp6bl941 631 17 / / SYM cord-302530-pp6bl941 631 18 Cr cr NN cord-302530-pp6bl941 631 19 binding binding NN cord-302530-pp6bl941 631 20 . . . cord-302530-pp6bl941 632 1 Decreasing decrease VBG cord-302530-pp6bl941 632 2 the the DT cord-302530-pp6bl941 632 3 size size NN cord-302530-pp6bl941 632 4 of of IN cord-302530-pp6bl941 632 5 a a DT cord-302530-pp6bl941 632 6 virus virus NN cord-302530-pp6bl941 632 7 makes make VBZ cord-302530-pp6bl941 632 8 ΔS ΔS NNP cord-302530-pp6bl941 632 9 a_immob a_immob NNP cord-302530-pp6bl941 632 10 less less RBR cord-302530-pp6bl941 632 11 negative negative JJ cord-302530-pp6bl941 632 12 ( ( -LRB- cord-302530-pp6bl941 632 13 Eq Eq NNP cord-302530-pp6bl941 632 14 . . . cord-302530-pp6bl941 633 1 ( ( -LRB- cord-302530-pp6bl941 633 2 18 18 CD cord-302530-pp6bl941 633 3 ) ) -RRB- cord-302530-pp6bl941 633 4 ) ) -RRB- cord-302530-pp6bl941 633 5 such such JJ cord-302530-pp6bl941 633 6 that that IN cord-302530-pp6bl941 633 7 smaller small JJR cord-302530-pp6bl941 633 8 viruses virus NNS cord-302530-pp6bl941 633 9 bind bind VBP cord-302530-pp6bl941 633 10 more more RBR cord-302530-pp6bl941 633 11 strongly strongly RB cord-302530-pp6bl941 633 12 at at IN cord-302530-pp6bl941 633 13 the the DT cord-302530-pp6bl941 633 14 higher high JJR cord-302530-pp6bl941 633 15 temperatures temperature NNS cord-302530-pp6bl941 633 16 of of IN cord-302530-pp6bl941 633 17 mammals mammal NNS cord-302530-pp6bl941 633 18 and and CC cord-302530-pp6bl941 633 19 birds bird NNS cord-302530-pp6bl941 633 20 ( ( -LRB- cord-302530-pp6bl941 633 21 Fig fig NN cord-302530-pp6bl941 633 22 . . . cord-302530-pp6bl941 633 23 5 5 CD cord-302530-pp6bl941 633 24 ) ) -RRB- cord-302530-pp6bl941 633 25 . . . cord-302530-pp6bl941 634 1 It -PRON- PRP cord-302530-pp6bl941 634 2 is be VBZ cord-302530-pp6bl941 634 3 suggested suggest VBN cord-302530-pp6bl941 634 4 that that IN cord-302530-pp6bl941 634 5 binding bind VBG cord-302530-pp6bl941 634 6 to to IN cord-302530-pp6bl941 634 7 cells cell NNS cord-302530-pp6bl941 634 8 at at IN cord-302530-pp6bl941 634 9 the the DT cord-302530-pp6bl941 634 10 higher high JJR cord-302530-pp6bl941 634 11 temperatures temperature NNS cord-302530-pp6bl941 634 12 of of IN cord-302530-pp6bl941 634 13 avian avian JJ cord-302530-pp6bl941 634 14 and and CC cord-302530-pp6bl941 634 15 mammalian mammalian JJ cord-302530-pp6bl941 634 16 hosts host NNS cord-302530-pp6bl941 634 17 selects select VBZ cord-302530-pp6bl941 634 18 for for IN cord-302530-pp6bl941 634 19 viruses virus NNS cord-302530-pp6bl941 634 20 of of IN cord-302530-pp6bl941 634 21 smaller small JJR cord-302530-pp6bl941 634 22 diameter diameter NN cord-302530-pp6bl941 634 23 through through IN cord-302530-pp6bl941 634 24 a a DT cord-302530-pp6bl941 634 25 less less RBR cord-302530-pp6bl941 634 26 negative negative JJ cord-302530-pp6bl941 634 27 ΔS ΔS NNP cord-302530-pp6bl941 634 28 a_immob a_immob NNP cord-302530-pp6bl941 634 29 . . . cord-302530-pp6bl941 635 1 This this DT cord-302530-pp6bl941 635 2 could could MD cord-302530-pp6bl941 635 3 explain explain VB cord-302530-pp6bl941 635 4 the the DT cord-302530-pp6bl941 635 5 decrease decrease NN cord-302530-pp6bl941 635 6 in in IN cord-302530-pp6bl941 635 7 volume volume NN cord-302530-pp6bl941 635 8 of of IN cord-302530-pp6bl941 635 9 viruses virus NNS cord-302530-pp6bl941 635 10 with with IN cord-302530-pp6bl941 635 11 increasing increase VBG cord-302530-pp6bl941 635 12 host host NN cord-302530-pp6bl941 635 13 / / SYM cord-302530-pp6bl941 635 14 environment environment NN cord-302530-pp6bl941 635 15 temperature temperature NN cord-302530-pp6bl941 635 16 as as IN cord-302530-pp6bl941 635 17 reported report VBN cord-302530-pp6bl941 635 18 by by IN cord-302530-pp6bl941 635 19 Nifong Nifong NNP cord-302530-pp6bl941 635 20 and and CC cord-302530-pp6bl941 635 21 Gillooly Gillooly NNP cord-302530-pp6bl941 635 22 ( ( -LRB- cord-302530-pp6bl941 635 23 2016 2016 CD cord-302530-pp6bl941 635 24 ) ) -RRB- cord-302530-pp6bl941 635 25 for for IN cord-302530-pp6bl941 635 26 dsDNA dsdna JJ cord-302530-pp6bl941 635 27 viruses virus NNS cord-302530-pp6bl941 635 28 . . . cord-302530-pp6bl941 636 1 Thus thus RB cord-302530-pp6bl941 636 2 the the DT cord-302530-pp6bl941 636 3 average average JJ cord-302530-pp6bl941 636 4 diameters diameter NNS cord-302530-pp6bl941 636 5 of of IN cord-302530-pp6bl941 636 6 dsDNA dsdna JJ cord-302530-pp6bl941 636 7 viruses virus NNS cord-302530-pp6bl941 636 8 decreased decrease VBD cord-302530-pp6bl941 636 9 from from IN cord-302530-pp6bl941 636 10 182 182 CD cord-302530-pp6bl941 636 11 nm nm NN cord-302530-pp6bl941 636 12 at at IN cord-302530-pp6bl941 636 13 a a DT cord-302530-pp6bl941 636 14 host host NN cord-302530-pp6bl941 636 15 / / SYM cord-302530-pp6bl941 636 16 environment environment NN cord-302530-pp6bl941 636 17 temperature temperature NN cord-302530-pp6bl941 636 18 of of IN cord-302530-pp6bl941 636 19 10 10 CD cord-302530-pp6bl941 636 20 ° ° NN cord-302530-pp6bl941 636 21 C c NN cord-302530-pp6bl941 636 22 down down RB cord-302530-pp6bl941 636 23 to to IN cord-302530-pp6bl941 636 24 74 74 CD cord-302530-pp6bl941 636 25 nm nm NN cord-302530-pp6bl941 636 26 at at IN cord-302530-pp6bl941 636 27 37 37 CD cord-302530-pp6bl941 636 28 ° ° NN cord-302530-pp6bl941 636 29 C c NN cord-302530-pp6bl941 636 30 according accord VBG cord-302530-pp6bl941 636 31 to to IN cord-302530-pp6bl941 636 32 the the DT cord-302530-pp6bl941 636 33 best good JJS cord-302530-pp6bl941 636 34 fit fit JJ cord-302530-pp6bl941 636 35 line line NN cord-302530-pp6bl941 636 36 of of IN cord-302530-pp6bl941 636 37 Nifong Nifong NNP cord-302530-pp6bl941 636 38 and and CC cord-302530-pp6bl941 636 39 Gillooly Gillooly NNP cord-302530-pp6bl941 636 40 ( ( -LRB- cord-302530-pp6bl941 636 41 2016 2016 CD cord-302530-pp6bl941 636 42 ) ) -RRB- cord-302530-pp6bl941 636 43 suggesting suggest VBG cord-302530-pp6bl941 636 44 the the DT cord-302530-pp6bl941 636 45 HIV HIV NNP cord-302530-pp6bl941 636 46 virion virion NN cord-302530-pp6bl941 636 47 at at IN cord-302530-pp6bl941 636 48 134 134 CD cord-302530-pp6bl941 636 49 nm nm NN cord-302530-pp6bl941 637 1 mean mean JJ cord-302530-pp6bl941 637 2 diameter diameter NN cord-302530-pp6bl941 637 3 is be VBZ cord-302530-pp6bl941 637 4 almost almost RB cord-302530-pp6bl941 637 5 double double PDT cord-302530-pp6bl941 637 6 the the DT cord-302530-pp6bl941 637 7 size size NN cord-302530-pp6bl941 637 8 for for IN cord-302530-pp6bl941 637 9 a a DT cord-302530-pp6bl941 637 10 virus virus NN cord-302530-pp6bl941 637 11 infecting infect VBG cord-302530-pp6bl941 637 12 at at IN cord-302530-pp6bl941 637 13 avian avian JJ cord-302530-pp6bl941 637 14 / / SYM cord-302530-pp6bl941 637 15 mammalian mammalian JJ cord-302530-pp6bl941 637 16 host host NN cord-302530-pp6bl941 637 17 temperature temperature NN cord-302530-pp6bl941 637 18 . . . cord-302530-pp6bl941 638 1 It -PRON- PRP cord-302530-pp6bl941 638 2 is be VBZ cord-302530-pp6bl941 638 3 interesting interesting JJ cord-302530-pp6bl941 638 4 to to TO cord-302530-pp6bl941 638 5 note note VB cord-302530-pp6bl941 638 6 that that IN cord-302530-pp6bl941 638 7 thermophilic thermophilic JJ cord-302530-pp6bl941 638 8 bacteria bacteria NNS cord-302530-pp6bl941 638 9 adapted adapt VBN cord-302530-pp6bl941 638 10 to to IN cord-302530-pp6bl941 638 11 high high JJ cord-302530-pp6bl941 638 12 temperature temperature NN cord-302530-pp6bl941 638 13 may may MD cord-302530-pp6bl941 638 14 be be VB cord-302530-pp6bl941 638 15 subject subject JJ cord-302530-pp6bl941 638 16 to to IN cord-302530-pp6bl941 638 17 selection selection NN cord-302530-pp6bl941 638 18 favouring favour VBG cord-302530-pp6bl941 638 19 smaller small JJR cord-302530-pp6bl941 638 20 cell cell NN cord-302530-pp6bl941 638 21 size size NN cord-302530-pp6bl941 638 22 . . . cord-302530-pp6bl941 639 1 This this DT cord-302530-pp6bl941 639 2 may may MD cord-302530-pp6bl941 639 3 aid aid VB cord-302530-pp6bl941 639 4 attachment attachment NN cord-302530-pp6bl941 639 5 to to IN cord-302530-pp6bl941 639 6 biofilms biofilm NNS cord-302530-pp6bl941 639 7 which which WDT cord-302530-pp6bl941 639 8 provide provide VBP cord-302530-pp6bl941 639 9 some some DT cord-302530-pp6bl941 639 10 protection protection NN cord-302530-pp6bl941 639 11 against against IN cord-302530-pp6bl941 639 12 temperature temperature NN cord-302530-pp6bl941 639 13 stress stress NN cord-302530-pp6bl941 639 14 . . . cord-302530-pp6bl941 640 1 It -PRON- PRP cord-302530-pp6bl941 640 2 is be VBZ cord-302530-pp6bl941 640 3 proposed propose VBN cord-302530-pp6bl941 640 4 here here RB cord-302530-pp6bl941 640 5 that that IN cord-302530-pp6bl941 640 6 by by IN cord-302530-pp6bl941 640 7 taking take VBG cord-302530-pp6bl941 640 8 the the DT cord-302530-pp6bl941 640 9 entropy entropy NN cord-302530-pp6bl941 640 10 loss loss NN cord-302530-pp6bl941 640 11 ΔS ΔS NNP cord-302530-pp6bl941 640 12 a_non_specific a_non_specific NN cord-302530-pp6bl941 640 13 in in IN cord-302530-pp6bl941 640 14 ΔS ΔS NNP cord-302530-pp6bl941 640 15 a_immob a_immob NNP cord-302530-pp6bl941 640 16 that that IN cord-302530-pp6bl941 640 17 non non JJ cord-302530-pp6bl941 640 18 - - JJ cord-302530-pp6bl941 640 19 specific specific JJ cord-302530-pp6bl941 640 20 binding binding NN cord-302530-pp6bl941 640 21 to to IN cord-302530-pp6bl941 640 22 attachment attachment NN cord-302530-pp6bl941 640 23 factors factor NNS cord-302530-pp6bl941 640 24 facilitates facilitate VBZ cord-302530-pp6bl941 640 25 subsequent subsequent JJ cord-302530-pp6bl941 640 26 specific specific JJ cord-302530-pp6bl941 640 27 HIV HIV NNP cord-302530-pp6bl941 640 28 Env Env NNP cord-302530-pp6bl941 640 29 binding binding NN cord-302530-pp6bl941 640 30 to to IN cord-302530-pp6bl941 640 31 CD4 CD4 NNP cord-302530-pp6bl941 640 32 receptors receptor NNS cord-302530-pp6bl941 640 33 on on IN cord-302530-pp6bl941 640 34 the the DT cord-302530-pp6bl941 640 35 host host NN cord-302530-pp6bl941 640 36 CD4 CD4 NNP cord-302530-pp6bl941 640 37 + + CC cord-302530-pp6bl941 640 38 T T NNP cord-302530-pp6bl941 640 39 cell cell NN cord-302530-pp6bl941 640 40 at at IN cord-302530-pp6bl941 640 41 human human JJ cord-302530-pp6bl941 640 42 body body NN cord-302530-pp6bl941 640 43 temperature temperature NN cord-302530-pp6bl941 640 44 . . . cord-302530-pp6bl941 641 1 Thus thus RB cord-302530-pp6bl941 641 2 the the DT cord-302530-pp6bl941 641 3 shift shift NN cord-302530-pp6bl941 641 4 in in IN cord-302530-pp6bl941 641 5 the the DT cord-302530-pp6bl941 641 6 K K NNP cord-302530-pp6bl941 641 7 a_virus_T a_virus_T NNP cord-302530-pp6bl941 641 8 curve curve NN cord-302530-pp6bl941 641 9 to to IN cord-302530-pp6bl941 641 10 higher high JJR cord-302530-pp6bl941 641 11 values value NNS cord-302530-pp6bl941 641 12 with with IN cord-302530-pp6bl941 641 13 a a DT cord-302530-pp6bl941 641 14 less less RBR cord-302530-pp6bl941 641 15 negative negative JJ cord-302530-pp6bl941 641 16 ΔS ΔS NNP cord-302530-pp6bl941 641 17 a_immob a_immob NNP cord-302530-pp6bl941 641 18 in in IN cord-302530-pp6bl941 641 19 Fig Fig NNP cord-302530-pp6bl941 641 20 . . . cord-302530-pp6bl941 642 1 5a 5a CD cord-302530-pp6bl941 642 2 is be VBZ cord-302530-pp6bl941 642 3 consistent consistent JJ cord-302530-pp6bl941 642 4 with with IN cord-302530-pp6bl941 642 5 HIV HIV NNP cord-302530-pp6bl941 642 6 attachment attachment NN cord-302530-pp6bl941 642 7 factors factor NNS cord-302530-pp6bl941 642 8 augmenting augment VBG cord-302530-pp6bl941 642 9 infection infection NN cord-302530-pp6bl941 643 1 ( ( -LRB- cord-302530-pp6bl941 643 2 Wilen Wilen NNP cord-302530-pp6bl941 643 3 et et NNP cord-302530-pp6bl941 643 4 al al NNP cord-302530-pp6bl941 643 5 . . NNP cord-302530-pp6bl941 643 6 , , , cord-302530-pp6bl941 643 7 2012 2012 CD cord-302530-pp6bl941 643 8 ) ) -RRB- cord-302530-pp6bl941 643 9 . . . cord-302530-pp6bl941 644 1 Indeed indeed RB cord-302530-pp6bl941 644 2 with with IN cord-302530-pp6bl941 644 3 n n NN cord-302530-pp6bl941 644 4 = = SYM cord-302530-pp6bl941 644 5 3 3 CD cord-302530-pp6bl941 644 6 Env env NN cord-302530-pp6bl941 644 7 : : : cord-302530-pp6bl941 644 8 CD4 CD4 NNP cord-302530-pp6bl941 644 9 contacts contact NNS cord-302530-pp6bl941 644 10 , , , cord-302530-pp6bl941 644 11 significant significant JJ cord-302530-pp6bl941 644 12 binding binding NN cord-302530-pp6bl941 644 13 of of IN cord-302530-pp6bl941 644 14 HIV HIV NNP cord-302530-pp6bl941 644 15 to to TO cord-302530-pp6bl941 644 16 host host VB cord-302530-pp6bl941 644 17 cells cell NNS cord-302530-pp6bl941 644 18 is be VBZ cord-302530-pp6bl941 644 19 only only RB cord-302530-pp6bl941 644 20 achieved achieve VBN cord-302530-pp6bl941 644 21 at at IN cord-302530-pp6bl941 644 22 37 37 CD cord-302530-pp6bl941 644 23 ° ° NN cord-302530-pp6bl941 644 24 C c NN cord-302530-pp6bl941 644 25 if if IN cord-302530-pp6bl941 644 26 ΔS ΔS NNP cord-302530-pp6bl941 644 27 a_immob a_immob NNP cord-302530-pp6bl941 644 28 is be VBZ cord-302530-pp6bl941 644 29 increased increase VBN cord-302530-pp6bl941 644 30 to to IN cord-302530-pp6bl941 644 31 > > XX cord-302530-pp6bl941 645 1 −280 −280 NFP cord-302530-pp6bl941 645 2 J/ J/ NNP cord-302530-pp6bl941 645 3 mol mol NN cord-302530-pp6bl941 645 4 / / SYM cord-302530-pp6bl941 645 5 K K NNP cord-302530-pp6bl941 645 6 ( ( -LRB- cord-302530-pp6bl941 645 7 Fig Fig NNP cord-302530-pp6bl941 645 8 . . . cord-302530-pp6bl941 645 9 5c 5c CD cord-302530-pp6bl941 645 10 ) ) -RRB- cord-302530-pp6bl941 645 11 . . . cord-302530-pp6bl941 646 1 ΔS ΔS NNP cord-302530-pp6bl941 646 2 a_immob a_immob NNP cord-302530-pp6bl941 646 3 is be VBZ cord-302530-pp6bl941 646 4 estimated estimate VBN cord-302530-pp6bl941 646 5 here here RB cord-302530-pp6bl941 646 6 to to TO cord-302530-pp6bl941 646 7 be be VB cord-302530-pp6bl941 646 8 −1091 −1091 NNP cord-302530-pp6bl941 646 9 J J NNP cord-302530-pp6bl941 646 10 / / SYM cord-302530-pp6bl941 646 11 mol mol NNP cord-302530-pp6bl941 646 12 / / SYM cord-302530-pp6bl941 646 13 K K NNP cord-302530-pp6bl941 646 14 for for IN cord-302530-pp6bl941 646 15 HIV HIV NNP cord-302530-pp6bl941 646 16 . . . cord-302530-pp6bl941 647 1 Thus thus RB cord-302530-pp6bl941 647 2 the the DT cord-302530-pp6bl941 647 3 prior prior JJ cord-302530-pp6bl941 647 4 non non JJ cord-302530-pp6bl941 647 5 - - JJ cord-302530-pp6bl941 647 6 specific specific JJ cord-302530-pp6bl941 647 7 binding binding NN cord-302530-pp6bl941 647 8 of of IN cord-302530-pp6bl941 647 9 HIV HIV NNP cord-302530-pp6bl941 647 10 would would MD cord-302530-pp6bl941 647 11 need need VB cord-302530-pp6bl941 647 12 to to TO cord-302530-pp6bl941 647 13 realise realise VB cord-302530-pp6bl941 647 14 a a DT cord-302530-pp6bl941 647 15 ΔS δs NN cord-302530-pp6bl941 647 16 a_non_specific a_non_specific NN cord-302530-pp6bl941 647 17 of of IN cord-302530-pp6bl941 647 18 −810 −810 NNP cord-302530-pp6bl941 647 19 J J NNP cord-302530-pp6bl941 647 20 / / SYM cord-302530-pp6bl941 647 21 mol mol NNP cord-302530-pp6bl941 647 22 / / SYM cord-302530-pp6bl941 647 23 K K NNP cord-302530-pp6bl941 647 24 for for IN cord-302530-pp6bl941 647 25 subsequent subsequent JJ cord-302530-pp6bl941 647 26 effective effective JJ cord-302530-pp6bl941 647 27 Env Env NNP cord-302530-pp6bl941 647 28 : : : cord-302530-pp6bl941 647 29 CD4 CD4 NNP cord-302530-pp6bl941 647 30 binding bind VBG cord-302530-pp6bl941 647 31 at at IN cord-302530-pp6bl941 647 32 human human JJ cord-302530-pp6bl941 647 33 body body NN cord-302530-pp6bl941 647 34 temperature temperature NN cord-302530-pp6bl941 647 35 according accord VBG cord-302530-pp6bl941 647 36 to to IN cord-302530-pp6bl941 647 37 the the DT cord-302530-pp6bl941 647 38 model model NN cord-302530-pp6bl941 647 39 such such JJ cord-302530-pp6bl941 647 40 that that DT cord-302530-pp6bl941 647 41 ΔS ΔS NNP cord-302530-pp6bl941 648 1 a_non_specific a_non_specific JJ cord-302530-pp6bl941 648 2 in in IN cord-302530-pp6bl941 648 3 Eq Eq NNP cord-302530-pp6bl941 648 4 . . . cord-302530-pp6bl941 649 1 ( ( -LRB- cord-302530-pp6bl941 649 2 19 19 CD cord-302530-pp6bl941 649 3 ) ) -RRB- cord-302530-pp6bl941 649 4 takes~75 takes~75 JJ cord-302530-pp6bl941 649 5 % % NN cord-302530-pp6bl941 649 6 of of IN cord-302530-pp6bl941 649 7 the the DT cord-302530-pp6bl941 649 8 entropy entropy NN cord-302530-pp6bl941 649 9 loss loss NN cord-302530-pp6bl941 649 10 in in IN cord-302530-pp6bl941 649 11 ΔS ΔS NNP cord-302530-pp6bl941 649 12 a_immob a_immob NNP cord-302530-pp6bl941 649 13 . . . cord-302530-pp6bl941 650 1 Wilen Wilen NNP cord-302530-pp6bl941 650 2 et et NNP cord-302530-pp6bl941 650 3 al al NNP cord-302530-pp6bl941 650 4 . . . cord-302530-pp6bl941 651 1 ( ( -LRB- cord-302530-pp6bl941 651 2 2012 2012 CD cord-302530-pp6bl941 651 3 ) ) -RRB- cord-302530-pp6bl941 651 4 also also RB cord-302530-pp6bl941 651 5 report report VBP cord-302530-pp6bl941 651 6 that that IN cord-302530-pp6bl941 651 7 HIV HIV NNP cord-302530-pp6bl941 651 8 attachment attachment NN cord-302530-pp6bl941 651 9 factors factor NNS cord-302530-pp6bl941 651 10 are be VBP cord-302530-pp6bl941 651 11 not not RB cord-302530-pp6bl941 651 12 essential essential JJ cord-302530-pp6bl941 651 13 . . . cord-302530-pp6bl941 652 1 Again again RB cord-302530-pp6bl941 652 2 this this DT cord-302530-pp6bl941 652 3 is be VBZ cord-302530-pp6bl941 652 4 consistent consistent JJ cord-302530-pp6bl941 652 5 with with IN cord-302530-pp6bl941 652 6 the the DT cord-302530-pp6bl941 652 7 model model NN cord-302530-pp6bl941 652 8 here here RB cord-302530-pp6bl941 652 9 when when WRB cord-302530-pp6bl941 652 10 it -PRON- PRP cord-302530-pp6bl941 652 11 is be VBZ cord-302530-pp6bl941 652 12 noted note VBN cord-302530-pp6bl941 652 13 that that IN cord-302530-pp6bl941 652 14 the the DT cord-302530-pp6bl941 652 15 C.V C.V NNP cord-302530-pp6bl941 652 16 T T NNP cord-302530-pp6bl941 652 17 value value NN cord-302530-pp6bl941 652 18 of of IN cord-302530-pp6bl941 652 19 < < NNP cord-302530-pp6bl941 652 20 1 1 CD cord-302530-pp6bl941 652 21 CD4 CD4 NNP cord-302530-pp6bl941 652 22 + + CC cord-302530-pp6bl941 652 23 T t NN cord-302530-pp6bl941 652 24 cell cell NN cord-302530-pp6bl941 652 25 with with IN cord-302530-pp6bl941 652 26 bound bind VBN cord-302530-pp6bl941 652 27 virus virus NN cord-302530-pp6bl941 652 28 in in IN cord-302530-pp6bl941 652 29 Fig Fig NNP cord-302530-pp6bl941 652 30 . . . cord-302530-pp6bl941 653 1 5b 5b NN cord-302530-pp6bl941 653 2 is be VBZ cord-302530-pp6bl941 653 3 not not RB cord-302530-pp6bl941 653 4 a a DT cord-302530-pp6bl941 653 5 threshold threshold NN cord-302530-pp6bl941 653 6 and and CC cord-302530-pp6bl941 653 7 merely merely RB cord-302530-pp6bl941 653 8 represents represent VBZ cord-302530-pp6bl941 653 9 1 1 CD cord-302530-pp6bl941 653 10 mm mm CD cord-302530-pp6bl941 653 11 3 3 CD cord-302530-pp6bl941 653 12 of of IN cord-302530-pp6bl941 653 13 blood blood NN cord-302530-pp6bl941 653 14 . . . cord-302530-pp6bl941 654 1 Thus thus RB cord-302530-pp6bl941 654 2 with with IN cord-302530-pp6bl941 654 3 ΔS ΔS NNP cord-302530-pp6bl941 654 4 a_immob a_immob NNP cord-302530-pp6bl941 654 5 = = NFP cord-302530-pp6bl941 655 1 −348 −348 NNP cord-302530-pp6bl941 655 2 J J NNP cord-302530-pp6bl941 655 3 / / SYM cord-302530-pp6bl941 655 4 mol mol NNP cord-302530-pp6bl941 655 5 / / SYM cord-302530-pp6bl941 655 6 K K NNP cord-302530-pp6bl941 655 7 , , , cord-302530-pp6bl941 655 8 C.V C.V NNP cord-302530-pp6bl941 655 9 T T NNP cord-302530-pp6bl941 655 10 = = SYM cord-302530-pp6bl941 655 11 1 1 CD cord-302530-pp6bl941 655 12 × × NN cord-302530-pp6bl941 655 13 10 10 CD cord-302530-pp6bl941 655 14 −3 −3 NN cord-302530-pp6bl941 655 15 at at IN cord-302530-pp6bl941 655 16 37 37 CD cord-302530-pp6bl941 655 17 ° ° NN cord-302530-pp6bl941 655 18 C c NN cord-302530-pp6bl941 655 19 ( ( -LRB- cord-302530-pp6bl941 655 20 Fig Fig NNP cord-302530-pp6bl941 655 21 . . . cord-302530-pp6bl941 655 22 5c 5c CD cord-302530-pp6bl941 655 23 ) ) -RRB- cord-302530-pp6bl941 655 24 . . . cord-302530-pp6bl941 656 1 This this DT cord-302530-pp6bl941 656 2 represents represent VBZ cord-302530-pp6bl941 656 3 one one CD cord-302530-pp6bl941 656 4 CD4 CD4 NNP cord-302530-pp6bl941 656 5 + + CC cord-302530-pp6bl941 656 6 T t NN cord-302530-pp6bl941 656 7 cell cell NN cord-302530-pp6bl941 656 8 with with IN cord-302530-pp6bl941 656 9 bound bind VBN cord-302530-pp6bl941 656 10 HIV HIV NNP cord-302530-pp6bl941 656 11 in in IN cord-302530-pp6bl941 656 12 1000 1000 CD cord-302530-pp6bl941 656 13 × × NN cord-302530-pp6bl941 656 14 1 1 CD cord-302530-pp6bl941 656 15 mm mm NNP cord-302530-pp6bl941 656 16 3 3 CD cord-302530-pp6bl941 656 17 vol vol NN cord-302530-pp6bl941 656 18 of of IN cord-302530-pp6bl941 656 19 blood blood NN cord-302530-pp6bl941 656 20 , , , cord-302530-pp6bl941 656 21 i.e. i.e. FW cord-302530-pp6bl941 656 22 in in IN cord-302530-pp6bl941 656 23 1 1 CD cord-302530-pp6bl941 656 24 cm cm NNS cord-302530-pp6bl941 656 25 3 3 CD cord-302530-pp6bl941 656 26 of of IN cord-302530-pp6bl941 656 27 blood blood NN cord-302530-pp6bl941 656 28 . . . cord-302530-pp6bl941 657 1 Decreasing decrease VBG cord-302530-pp6bl941 657 2 ΔS ΔS NNP cord-302530-pp6bl941 657 3 a_immob a_immob NNP cord-302530-pp6bl941 657 4 further further RB cord-302530-pp6bl941 657 5 to to IN cord-302530-pp6bl941 657 6 −405 −405 ADD cord-302530-pp6bl941 658 1 J/ J/ NNP cord-302530-pp6bl941 658 2 mol mol NN cord-302530-pp6bl941 658 3 / / SYM cord-302530-pp6bl941 658 4 K K NNP cord-302530-pp6bl941 658 5 gives give VBZ cord-302530-pp6bl941 658 6 C.V C.V NNP cord-302530-pp6bl941 658 7 T T NNP cord-302530-pp6bl941 658 8 = = SYM cord-302530-pp6bl941 658 9 1 1 CD cord-302530-pp6bl941 658 10 × × NNP cord-302530-pp6bl941 658 11 10 10 CD cord-302530-pp6bl941 658 12 −6 −6 NNS cord-302530-pp6bl941 658 13 at at IN cord-302530-pp6bl941 658 14 37 37 CD cord-302530-pp6bl941 658 15 ° ° NN cord-302530-pp6bl941 658 16 C c NN cord-302530-pp6bl941 658 17 representing represent VBG cord-302530-pp6bl941 658 18 one one CD cord-302530-pp6bl941 658 19 CD4 CD4 NNP cord-302530-pp6bl941 658 20 + + CC cord-302530-pp6bl941 658 21 T t NN cord-302530-pp6bl941 658 22 cell cell NN cord-302530-pp6bl941 658 23 with with IN cord-302530-pp6bl941 658 24 bound bind VBN cord-302530-pp6bl941 658 25 HIV HIV NNP cord-302530-pp6bl941 658 26 in in IN cord-302530-pp6bl941 658 27 1 1 CD cord-302530-pp6bl941 658 28 litre litre NN cord-302530-pp6bl941 658 29 of of IN cord-302530-pp6bl941 658 30 blood blood NN cord-302530-pp6bl941 658 31 . . . cord-302530-pp6bl941 659 1 The the DT cord-302530-pp6bl941 659 2 model model NN cord-302530-pp6bl941 659 3 here here RB cord-302530-pp6bl941 659 4 suggests suggest VBZ cord-302530-pp6bl941 659 5 human human JJ cord-302530-pp6bl941 659 6 body body NN cord-302530-pp6bl941 659 7 temperature temperature NN cord-302530-pp6bl941 659 8 may may MD cord-302530-pp6bl941 659 9 be be VB cord-302530-pp6bl941 659 10 a a DT cord-302530-pp6bl941 659 11 constraint constraint NN cord-302530-pp6bl941 659 12 on on IN cord-302530-pp6bl941 659 13 HIV HIV NNP cord-302530-pp6bl941 659 14 binding binding NN cord-302530-pp6bl941 659 15 ( ( -LRB- cord-302530-pp6bl941 659 16 due due IN cord-302530-pp6bl941 659 17 to to IN cord-302530-pp6bl941 659 18 the the DT cord-302530-pp6bl941 659 19 large large JJ cord-302530-pp6bl941 659 20 negative negative JJ cord-302530-pp6bl941 659 21 values value NNS cord-302530-pp6bl941 659 22 of of IN cord-302530-pp6bl941 659 23 both both DT cord-302530-pp6bl941 659 24 ΔC ΔC NNP cord-302530-pp6bl941 659 25 p p NN cord-302530-pp6bl941 659 26 and and CC cord-302530-pp6bl941 659 27 ΔS ΔS NNP cord-302530-pp6bl941 659 28 a_immob a_immob NNP cord-302530-pp6bl941 659 29 ) ) -RRB- cord-302530-pp6bl941 659 30 in in IN cord-302530-pp6bl941 659 31 effect effect NN cord-302530-pp6bl941 659 32 exposing expose VBG cord-302530-pp6bl941 659 33 a a DT cord-302530-pp6bl941 659 34 potential potential JJ cord-302530-pp6bl941 659 35 weakness weakness NN cord-302530-pp6bl941 659 36 in in IN cord-302530-pp6bl941 659 37 the the DT cord-302530-pp6bl941 659 38 HIV HIV NNP cord-302530-pp6bl941 659 39 infection infection NN cord-302530-pp6bl941 659 40 strategy strategy NN cord-302530-pp6bl941 659 41 which which WDT cord-302530-pp6bl941 659 42 could could MD cord-302530-pp6bl941 659 43 be be VB cord-302530-pp6bl941 659 44 exploited exploit VBN cord-302530-pp6bl941 659 45 for for IN cord-302530-pp6bl941 659 46 antiviral antiviral JJ cord-302530-pp6bl941 659 47 therapy therapy NN cord-302530-pp6bl941 659 48 . . . cord-302530-pp6bl941 660 1 Figure figure NN cord-302530-pp6bl941 660 2 9 9 CD cord-302530-pp6bl941 660 3 of of IN cord-302530-pp6bl941 660 4 Antoine Antoine NNP cord-302530-pp6bl941 660 5 et et FW cord-302530-pp6bl941 660 6 al al NNP cord-302530-pp6bl941 660 7 . . . cord-302530-pp6bl941 661 1 ( ( -LRB- cord-302530-pp6bl941 661 2 2012 2012 CD cord-302530-pp6bl941 661 3 ) ) -RRB- cord-302530-pp6bl941 661 4 shows show VBZ cord-302530-pp6bl941 661 5 a a DT cord-302530-pp6bl941 661 6 herpes herpes NN cord-302530-pp6bl941 661 7 simplex simplex NN cord-302530-pp6bl941 661 8 virus virus NN cord-302530-pp6bl941 661 9 type type NN cord-302530-pp6bl941 661 10 2 2 CD cord-302530-pp6bl941 662 1 ( ( -LRB- cord-302530-pp6bl941 662 2 HSV-2 HSV-2 NNP cord-302530-pp6bl941 662 3 ) ) -RRB- cord-302530-pp6bl941 662 4 bound bind VBN cord-302530-pp6bl941 662 5 to to IN cord-302530-pp6bl941 662 6 a a DT cord-302530-pp6bl941 662 7 tetrahedral tetrahedral JJ cord-302530-pp6bl941 662 8 nanoparticle nanoparticle NN cord-302530-pp6bl941 662 9 of of IN cord-302530-pp6bl941 662 10 zinc zinc NN cord-302530-pp6bl941 662 11 oxide oxide NN cord-302530-pp6bl941 662 12 ( ( -LRB- cord-302530-pp6bl941 662 13 ZnO ZnO NNP cord-302530-pp6bl941 662 14 ) ) -RRB- cord-302530-pp6bl941 662 15 called call VBD cord-302530-pp6bl941 662 16 a a DT cord-302530-pp6bl941 662 17 zinc zinc NN cord-302530-pp6bl941 662 18 oxide oxide NN cord-302530-pp6bl941 662 19 tetrapod tetrapod NN cord-302530-pp6bl941 662 20 ( ( -LRB- cord-302530-pp6bl941 662 21 ZnOT ZnOT NNP cord-302530-pp6bl941 662 22 ) ) -RRB- cord-302530-pp6bl941 662 23 . . . cord-302530-pp6bl941 663 1 The the DT cord-302530-pp6bl941 663 2 mechanism mechanism NN cord-302530-pp6bl941 663 3 behind behind IN cord-302530-pp6bl941 663 4 the the DT cord-302530-pp6bl941 663 5 ability ability NN cord-302530-pp6bl941 663 6 of of IN cord-302530-pp6bl941 663 7 ZnOTs znot NNS cord-302530-pp6bl941 663 8 to to TO cord-302530-pp6bl941 663 9 prevent prevent VB cord-302530-pp6bl941 663 10 , , , cord-302530-pp6bl941 663 11 neutralize neutralize VB cord-302530-pp6bl941 663 12 or or CC cord-302530-pp6bl941 663 13 reduce reduce VB cord-302530-pp6bl941 663 14 HSV-2 hsv-2 JJ cord-302530-pp6bl941 663 15 infection infection NN cord-302530-pp6bl941 663 16 relies rely VBZ cord-302530-pp6bl941 663 17 on on IN cord-302530-pp6bl941 663 18 their -PRON- PRP$ cord-302530-pp6bl941 663 19 ability ability NN cord-302530-pp6bl941 663 20 to to TO cord-302530-pp6bl941 663 21 bind bind VB cord-302530-pp6bl941 663 22 the the DT cord-302530-pp6bl941 663 23 HSV-2 hsv-2 JJ cord-302530-pp6bl941 663 24 virions virion NNS cord-302530-pp6bl941 663 25 ( ( -LRB- cord-302530-pp6bl941 663 26 Antoine Antoine NNP cord-302530-pp6bl941 663 27 et et FW cord-302530-pp6bl941 663 28 al al NNP cord-302530-pp6bl941 663 29 . . NNP cord-302530-pp6bl941 663 30 , , , cord-302530-pp6bl941 663 31 2012 2012 CD cord-302530-pp6bl941 663 32 ) ) -RRB- cord-302530-pp6bl941 663 33 . . . cord-302530-pp6bl941 664 1 The the DT cord-302530-pp6bl941 664 2 ZnOT znot NN cord-302530-pp6bl941 664 3 being be VBG cord-302530-pp6bl941 664 4 some some DT cord-302530-pp6bl941 664 5 40 40 CD cord-302530-pp6bl941 664 6 µm µm NN cord-302530-pp6bl941 664 7 in in IN cord-302530-pp6bl941 664 8 size size NN cord-302530-pp6bl941 664 9 is be VBZ cord-302530-pp6bl941 664 10 much much RB cord-302530-pp6bl941 664 11 larger large JJR cord-302530-pp6bl941 664 12 than than IN cord-302530-pp6bl941 664 13 the the DT cord-302530-pp6bl941 664 14 attached attach VBN cord-302530-pp6bl941 664 15 virion virion NN cord-302530-pp6bl941 664 16 which which WDT cord-302530-pp6bl941 664 17 could could MD cord-302530-pp6bl941 664 18 still still RB cord-302530-pp6bl941 664 19 attach attach VB cord-302530-pp6bl941 664 20 to to IN cord-302530-pp6bl941 664 21 a a DT cord-302530-pp6bl941 664 22 host host NN cord-302530-pp6bl941 664 23 cell cell NN cord-302530-pp6bl941 664 24 surface surface NN cord-302530-pp6bl941 664 25 in in IN cord-302530-pp6bl941 664 26 terms term NNS cord-302530-pp6bl941 664 27 of of IN cord-302530-pp6bl941 664 28 spatial spatial JJ cord-302530-pp6bl941 664 29 considerations consideration NNS cord-302530-pp6bl941 664 30 . . . cord-302530-pp6bl941 665 1 However however RB cord-302530-pp6bl941 665 2 , , , cord-302530-pp6bl941 665 3 the the DT cord-302530-pp6bl941 665 4 magnitude magnitude NN cord-302530-pp6bl941 665 5 of of IN cord-302530-pp6bl941 665 6 ΔS ΔS NNP cord-302530-pp6bl941 665 7 a_immob a_immob NNP cord-302530-pp6bl941 665 8 for for IN cord-302530-pp6bl941 665 9 an an DT cord-302530-pp6bl941 665 10 HSV-2 hsv-2 JJ cord-302530-pp6bl941 665 11 virion virion NN cord-302530-pp6bl941 665 12 bound bind VBN cord-302530-pp6bl941 665 13 to to IN cord-302530-pp6bl941 665 14 a a DT cord-302530-pp6bl941 665 15 ZnOT znot NN cord-302530-pp6bl941 665 16 nanoparticle nanoparticle NN cord-302530-pp6bl941 665 17 would would MD cord-302530-pp6bl941 665 18 be be VB cord-302530-pp6bl941 665 19 very very RB cord-302530-pp6bl941 665 20 large large JJ cord-302530-pp6bl941 665 21 and and CC cord-302530-pp6bl941 665 22 negative negative JJ cord-302530-pp6bl941 665 23 , , , cord-302530-pp6bl941 665 24 indeed indeed RB cord-302530-pp6bl941 665 25 much much RB cord-302530-pp6bl941 665 26 more more RBR cord-302530-pp6bl941 665 27 negative negative JJ cord-302530-pp6bl941 665 28 than than IN cord-302530-pp6bl941 665 29 for for IN cord-302530-pp6bl941 665 30 ΔS ΔS NNP cord-302530-pp6bl941 665 31 a_immob a_immob NNP cord-302530-pp6bl941 665 32 for for IN cord-302530-pp6bl941 665 33 a a DT cord-302530-pp6bl941 665 34 free free JJ cord-302530-pp6bl941 665 35 HSV-2 hsv-2 JJ cord-302530-pp6bl941 665 36 virion virion NN cord-302530-pp6bl941 665 37 . . . cord-302530-pp6bl941 666 1 Thus thus RB cord-302530-pp6bl941 666 2 according accord VBG cord-302530-pp6bl941 666 3 to to IN cord-302530-pp6bl941 666 4 Fig Fig NNP cord-302530-pp6bl941 666 5 . . . cord-302530-pp6bl941 667 1 5c 5c NNP cord-302530-pp6bl941 667 2 , , , cord-302530-pp6bl941 667 3 binding bind VBG cord-302530-pp6bl941 667 4 of of IN cord-302530-pp6bl941 667 5 HSV-2 HSV-2 NNP cord-302530-pp6bl941 667 6 / / SYM cord-302530-pp6bl941 667 7 ZnOT ZnOT NNP cord-302530-pp6bl941 667 8 to to TO cord-302530-pp6bl941 667 9 host host NN cord-302530-pp6bl941 667 10 cells cell NNS cord-302530-pp6bl941 667 11 would would MD cord-302530-pp6bl941 667 12 be be VB cord-302530-pp6bl941 667 13 greatly greatly RB cord-302530-pp6bl941 667 14 diminished diminish VBN cord-302530-pp6bl941 667 15 particularly particularly RB cord-302530-pp6bl941 667 16 at at IN cord-302530-pp6bl941 667 17 the the DT cord-302530-pp6bl941 667 18 human human JJ cord-302530-pp6bl941 667 19 body body NN cord-302530-pp6bl941 667 20 temperature temperature NN cord-302530-pp6bl941 667 21 due due IN cord-302530-pp6bl941 667 22 to to IN cord-302530-pp6bl941 667 23 the the DT cord-302530-pp6bl941 667 24 very very RB cord-302530-pp6bl941 667 25 large large JJ cord-302530-pp6bl941 667 26 negative negative JJ cord-302530-pp6bl941 667 27 ΔS ΔS NNP cord-302530-pp6bl941 667 28 a_immob a_immob NNP cord-302530-pp6bl941 667 29 . . . cord-302530-pp6bl941 668 1 Although although IN cord-302530-pp6bl941 668 2 ΔS ΔS NNP cord-302530-pp6bl941 668 3 a_immob a_immob NNP cord-302530-pp6bl941 668 4 changes change VBZ cord-302530-pp6bl941 668 5 logarithmically logarithmically RB cord-302530-pp6bl941 668 6 ( ( -LRB- cord-302530-pp6bl941 668 7 i.e. i.e. FW cord-302530-pp6bl941 668 8 slowly slowly RB cord-302530-pp6bl941 668 9 ) ) -RRB- cord-302530-pp6bl941 668 10 with with IN cord-302530-pp6bl941 668 11 virus virus NN cord-302530-pp6bl941 668 12 size size NN cord-302530-pp6bl941 668 13 according accord VBG cord-302530-pp6bl941 668 14 to to IN cord-302530-pp6bl941 668 15 Eq Eq NNP cord-302530-pp6bl941 668 16 . . . cord-302530-pp6bl941 669 1 ( ( -LRB- cord-302530-pp6bl941 669 2 18 18 CD cord-302530-pp6bl941 669 3 ) ) -RRB- cord-302530-pp6bl941 669 4 , , , cord-302530-pp6bl941 669 5 the the DT cord-302530-pp6bl941 669 6 number number NN cord-302530-pp6bl941 669 7 , , , cord-302530-pp6bl941 669 8 C.V C.V NNP cord-302530-pp6bl941 669 9 T T NNP cord-302530-pp6bl941 669 10 , , , cord-302530-pp6bl941 669 11 of of IN cord-302530-pp6bl941 669 12 cells cell NNS cord-302530-pp6bl941 669 13 with with IN cord-302530-pp6bl941 669 14 bound bind VBN cord-302530-pp6bl941 669 15 virus virus NN cord-302530-pp6bl941 669 16 is be VBZ cord-302530-pp6bl941 669 17 very very RB cord-302530-pp6bl941 669 18 sensitive sensitive JJ cord-302530-pp6bl941 669 19 to to IN cord-302530-pp6bl941 669 20 changes change NNS cord-302530-pp6bl941 669 21 in in IN cord-302530-pp6bl941 669 22 ΔS ΔS NNP cord-302530-pp6bl941 669 23 a_immob a_immob NNP cord-302530-pp6bl941 669 24 at at IN cord-302530-pp6bl941 669 25 37 37 CD cord-302530-pp6bl941 669 26 ° ° NN cord-302530-pp6bl941 669 27 C c NN cord-302530-pp6bl941 669 28 ( ( -LRB- cord-302530-pp6bl941 669 29 Fig Fig NNP cord-302530-pp6bl941 669 30 . . . cord-302530-pp6bl941 669 31 5c 5c CD cord-302530-pp6bl941 669 32 ) ) -RRB- cord-302530-pp6bl941 669 33 . . . cord-302530-pp6bl941 670 1 It -PRON- PRP cord-302530-pp6bl941 670 2 is be VBZ cord-302530-pp6bl941 670 3 proposed propose VBN cord-302530-pp6bl941 670 4 that that IN cord-302530-pp6bl941 670 5 antiviral antiviral JJ cord-302530-pp6bl941 670 6 research research NN cord-302530-pp6bl941 670 7 should should MD cord-302530-pp6bl941 670 8 take take VB cord-302530-pp6bl941 670 9 into into IN cord-302530-pp6bl941 670 10 account account NN cord-302530-pp6bl941 670 11 and and CC cord-302530-pp6bl941 670 12 even even RB cord-302530-pp6bl941 670 13 focus focus VB cord-302530-pp6bl941 670 14 on on IN cord-302530-pp6bl941 670 15 making make VBG cord-302530-pp6bl941 670 16 the the DT cord-302530-pp6bl941 670 17 magnitude magnitude NN cord-302530-pp6bl941 670 18 of of IN cord-302530-pp6bl941 670 19 ΔS ΔS NNP cord-302530-pp6bl941 670 20 a_immob a_immob NNP cord-302530-pp6bl941 670 21 more more RBR cord-302530-pp6bl941 670 22 negative negative JJ cord-302530-pp6bl941 670 23 in in IN cord-302530-pp6bl941 670 24 addition addition NN cord-302530-pp6bl941 670 25 to to IN cord-302530-pp6bl941 670 26 looking look VBG cord-302530-pp6bl941 670 27 at at IN cord-302530-pp6bl941 670 28 conventional conventional JJ cord-302530-pp6bl941 670 29 approaches approach NNS cord-302530-pp6bl941 670 30 to to TO cord-302530-pp6bl941 670 31 block block VB cord-302530-pp6bl941 670 32 the the DT cord-302530-pp6bl941 670 33 GP GP NNP cord-302530-pp6bl941 670 34 / / SYM cord-302530-pp6bl941 670 35 Cr cr NN cord-302530-pp6bl941 670 36 interaction interaction NN cord-302530-pp6bl941 670 37 . . . cord-302530-pp6bl941 671 1 The the DT cord-302530-pp6bl941 671 2 advantage advantage NN cord-302530-pp6bl941 671 3 of of IN cord-302530-pp6bl941 671 4 focusing focus VBG cord-302530-pp6bl941 671 5 on on IN cord-302530-pp6bl941 671 6 ΔS ΔS NNP cord-302530-pp6bl941 671 7 a_immob a_immob NNP cord-302530-pp6bl941 671 8 is be VBZ cord-302530-pp6bl941 671 9 that that IN cord-302530-pp6bl941 671 10 only only RB cord-302530-pp6bl941 671 11 one one CD cord-302530-pp6bl941 671 12 ZnOT znot NN cord-302530-pp6bl941 671 13 nanoparticle nanoparticle NN cord-302530-pp6bl941 671 14 has have VBZ cord-302530-pp6bl941 671 15 to to TO cord-302530-pp6bl941 671 16 bind bind VB cord-302530-pp6bl941 671 17 to to IN cord-302530-pp6bl941 671 18 a a DT cord-302530-pp6bl941 671 19 virus virus NN cord-302530-pp6bl941 671 20 to to TO cord-302530-pp6bl941 671 21 markedly markedly RB cord-302530-pp6bl941 671 22 affect affect VB cord-302530-pp6bl941 671 23 ΔS ΔS NNP cord-302530-pp6bl941 671 24 a_immob a_immob NNP cord-302530-pp6bl941 671 25 , , , cord-302530-pp6bl941 671 26 while while IN cord-302530-pp6bl941 671 27 a a DT cord-302530-pp6bl941 671 28 large large JJ cord-302530-pp6bl941 671 29 proportion proportion NN cord-302530-pp6bl941 671 30 of of IN cord-302530-pp6bl941 671 31 the the DT cord-302530-pp6bl941 671 32 GP GP NNP cord-302530-pp6bl941 671 33 molecules molecule NNS cord-302530-pp6bl941 671 34 on on IN cord-302530-pp6bl941 671 35 the the DT cord-302530-pp6bl941 671 36 virus virus NN cord-302530-pp6bl941 671 37 have have VBP cord-302530-pp6bl941 671 38 to to TO cord-302530-pp6bl941 671 39 be be VB cord-302530-pp6bl941 671 40 bound bind VBN cord-302530-pp6bl941 671 41 with with IN cord-302530-pp6bl941 671 42 inhibitors inhibitor NNS cord-302530-pp6bl941 671 43 , , , cord-302530-pp6bl941 671 44 including include VBG cord-302530-pp6bl941 671 45 neutralising neutralise VBG cord-302530-pp6bl941 671 46 antibodies antibody NNS cord-302530-pp6bl941 671 47 , , , cord-302530-pp6bl941 671 48 to to TO cord-302530-pp6bl941 671 49 block block VB cord-302530-pp6bl941 671 50 virus virus NN cord-302530-pp6bl941 671 51 binding bind VBG cord-302530-pp6bl941 671 52 ( ( -LRB- cord-302530-pp6bl941 671 53 Klasse Klasse NNP cord-302530-pp6bl941 671 54 2012 2012 CD cord-302530-pp6bl941 671 55 ) ) -RRB- cord-302530-pp6bl941 671 56 and and CC cord-302530-pp6bl941 671 57 hence hence RB cord-302530-pp6bl941 671 58 eliminate eliminate VB cord-302530-pp6bl941 671 59 ΔH ΔH NNP cord-302530-pp6bl941 671 60 a_receptor_T0 a_receptor_t0 NN cord-302530-pp6bl941 671 61 in in IN cord-302530-pp6bl941 671 62 Eq Eq NNP cord-302530-pp6bl941 671 63 . . . cord-302530-pp6bl941 672 1 ( ( -LRB- cord-302530-pp6bl941 672 2 11 11 CD cord-302530-pp6bl941 672 3 ) ) -RRB- cord-302530-pp6bl941 672 4 . . . cord-302530-pp6bl941 673 1 The the DT cord-302530-pp6bl941 673 2 temperature temperature NN cord-302530-pp6bl941 673 3 dependence dependence NN cord-302530-pp6bl941 673 4 of of IN cord-302530-pp6bl941 673 5 virus virus NN cord-302530-pp6bl941 673 6 diffusion diffusion NN cord-302530-pp6bl941 673 7 in in IN cord-302530-pp6bl941 673 8 mucus mucus NN cord-302530-pp6bl941 673 9 ( ( -LRB- cord-302530-pp6bl941 673 10 Erickson Erickson NNP cord-302530-pp6bl941 673 11 et et NNP cord-302530-pp6bl941 673 12 al al NNP cord-302530-pp6bl941 673 13 . . NNP cord-302530-pp6bl941 673 14 , , , cord-302530-pp6bl941 673 15 2015 2015 CD cord-302530-pp6bl941 673 16 ) ) -RRB- cord-302530-pp6bl941 673 17 could could MD cord-302530-pp6bl941 673 18 also also RB cord-302530-pp6bl941 673 19 be be VB cord-302530-pp6bl941 673 20 considered consider VBN cord-302530-pp6bl941 673 21 not not RB cord-302530-pp6bl941 673 22 only only RB cord-302530-pp6bl941 673 23 in in IN cord-302530-pp6bl941 673 24 mechanistic mechanistic JJ cord-302530-pp6bl941 673 25 dose dose JJ cord-302530-pp6bl941 673 26 - - HYPH cord-302530-pp6bl941 673 27 response response NN cord-302530-pp6bl941 673 28 models model NNS cord-302530-pp6bl941 673 29 for for IN cord-302530-pp6bl941 673 30 viral viral JJ cord-302530-pp6bl941 673 31 infection infection NN cord-302530-pp6bl941 673 32 at at IN cord-302530-pp6bl941 673 33 mucosal mucosal JJ cord-302530-pp6bl941 673 34 epithelial epithelial JJ cord-302530-pp6bl941 673 35 membranes membrane NNS cord-302530-pp6bl941 673 36 in in IN cord-302530-pp6bl941 673 37 the the DT cord-302530-pp6bl941 673 38 intestine intestine NN cord-302530-pp6bl941 673 39 ( ( -LRB- cord-302530-pp6bl941 673 40 Gale Gale NNP cord-302530-pp6bl941 673 41 2018 2018 CD cord-302530-pp6bl941 673 42 ) ) -RRB- cord-302530-pp6bl941 673 43 but but CC cord-302530-pp6bl941 673 44 also also RB cord-302530-pp6bl941 673 45 in in IN cord-302530-pp6bl941 673 46 terms term NNS cord-302530-pp6bl941 673 47 of of IN cord-302530-pp6bl941 673 48 therapeutics therapeutic NNS cord-302530-pp6bl941 673 49 when when WRB cord-302530-pp6bl941 673 50 combined combine VBN cord-302530-pp6bl941 673 51 with with IN cord-302530-pp6bl941 673 52 the the DT cord-302530-pp6bl941 673 53 thermodynamic thermodynamic JJ cord-302530-pp6bl941 673 54 approach approach NN cord-302530-pp6bl941 673 55 developed develop VBN cord-302530-pp6bl941 673 56 here here RB cord-302530-pp6bl941 673 57 . . . cord-302530-pp6bl941 674 1 Normal normal JJ cord-302530-pp6bl941 674 2 , , , cord-302530-pp6bl941 674 3 acidic acidic JJ cord-302530-pp6bl941 674 4 cervicovaginal cervicovaginal JJ cord-302530-pp6bl941 674 5 mucus mucus NN cord-302530-pp6bl941 674 6 greatly greatly RB cord-302530-pp6bl941 674 7 hinders hinder VBZ cord-302530-pp6bl941 674 8 the the DT cord-302530-pp6bl941 674 9 movement movement NN cord-302530-pp6bl941 674 10 of of IN cord-302530-pp6bl941 674 11 virions virion NNS cord-302530-pp6bl941 674 12 of of IN cord-302530-pp6bl941 674 13 HSV HSV NNP cord-302530-pp6bl941 674 14 and and CC cord-302530-pp6bl941 674 15 HIV HIV NNP cord-302530-pp6bl941 674 16 , , , cord-302530-pp6bl941 674 17 whereas whereas IN cord-302530-pp6bl941 674 18 mucus mucus NN cord-302530-pp6bl941 674 19 that that WDT cord-302530-pp6bl941 674 20 is be VBZ cord-302530-pp6bl941 674 21 neutralized neutralize VBN cord-302530-pp6bl941 674 22 by by IN cord-302530-pp6bl941 674 23 semen semen NN cord-302530-pp6bl941 674 24 provides provide VBZ cord-302530-pp6bl941 674 25 a a DT cord-302530-pp6bl941 674 26 much much RB cord-302530-pp6bl941 674 27 less less RBR cord-302530-pp6bl941 674 28 effective effective JJ cord-302530-pp6bl941 674 29 barrier barrier NN cord-302530-pp6bl941 674 30 against against IN cord-302530-pp6bl941 674 31 the the DT cord-302530-pp6bl941 674 32 same same JJ cord-302530-pp6bl941 674 33 virions virion NNS cord-302530-pp6bl941 674 34 ( ( -LRB- cord-302530-pp6bl941 674 35 Erickson Erickson NNP cord-302530-pp6bl941 674 36 et et NNP cord-302530-pp6bl941 674 37 al al NNP cord-302530-pp6bl941 674 38 . . NNP cord-302530-pp6bl941 674 39 , , , cord-302530-pp6bl941 674 40 2015 2015 CD cord-302530-pp6bl941 674 41 ) ) -RRB- cord-302530-pp6bl941 674 42 . . . cord-302530-pp6bl941 675 1 Thus thus RB cord-302530-pp6bl941 675 2 binding bind VBG cord-302530-pp6bl941 675 3 of of IN cord-302530-pp6bl941 675 4 the the DT cord-302530-pp6bl941 675 5 HSV HSV NNP cord-302530-pp6bl941 675 6 or or CC cord-302530-pp6bl941 675 7 HIV HIV NNP cord-302530-pp6bl941 675 8 virion virion NN cord-302530-pp6bl941 675 9 to to IN cord-302530-pp6bl941 675 10 a a DT cord-302530-pp6bl941 675 11 ZnOT znot NN cord-302530-pp6bl941 675 12 particle particle NN cord-302530-pp6bl941 675 13 may may MD cord-302530-pp6bl941 675 14 not not RB cord-302530-pp6bl941 675 15 only only RB cord-302530-pp6bl941 675 16 decrease decrease VB cord-302530-pp6bl941 675 17 its -PRON- PRP$ cord-302530-pp6bl941 675 18 diffusion diffusion NN cord-302530-pp6bl941 675 19 coefficient coefficient NN cord-302530-pp6bl941 675 20 in in IN cord-302530-pp6bl941 675 21 mucus mucus NN cord-302530-pp6bl941 675 22 but but CC cord-302530-pp6bl941 675 23 also also RB cord-302530-pp6bl941 675 24 make make VB cord-302530-pp6bl941 675 25 the the DT cord-302530-pp6bl941 675 26 magnitude magnitude NN cord-302530-pp6bl941 675 27 of of IN cord-302530-pp6bl941 675 28 ΔS ΔS NNP cord-302530-pp6bl941 675 29 a_immob a_immob NNP cord-302530-pp6bl941 675 30 more more RBR cord-302530-pp6bl941 675 31 negative negative JJ cord-302530-pp6bl941 675 32 hence hence RB cord-302530-pp6bl941 675 33 reducing reduce VBG cord-302530-pp6bl941 675 34 the the DT cord-302530-pp6bl941 675 35 binding bind VBG cord-302530-pp6bl941 675 36 affinity affinity NN cord-302530-pp6bl941 675 37 of of IN cord-302530-pp6bl941 675 38 those those DT cord-302530-pp6bl941 675 39 virions virion NNS cord-302530-pp6bl941 675 40 which which WDT cord-302530-pp6bl941 675 41 do do VBP cord-302530-pp6bl941 675 42 make make VB cord-302530-pp6bl941 675 43 it -PRON- PRP cord-302530-pp6bl941 675 44 through through IN cord-302530-pp6bl941 675 45 the the DT cord-302530-pp6bl941 675 46 mucus mucus NN cord-302530-pp6bl941 675 47 to to IN cord-302530-pp6bl941 675 48 the the DT cord-302530-pp6bl941 675 49 epithelial epithelial JJ cord-302530-pp6bl941 675 50 cell cell NN cord-302530-pp6bl941 675 51 surface surface NN cord-302530-pp6bl941 675 52 at at IN cord-302530-pp6bl941 675 53 human human JJ cord-302530-pp6bl941 675 54 body body NN cord-302530-pp6bl941 675 55 temperature temperature NN cord-302530-pp6bl941 675 56 . . . cord-302530-pp6bl941 676 1 It -PRON- PRP cord-302530-pp6bl941 676 2 is be VBZ cord-302530-pp6bl941 676 3 assumed assume VBN cord-302530-pp6bl941 676 4 for for IN cord-302530-pp6bl941 676 5 the the DT cord-302530-pp6bl941 676 6 purpose purpose NN cord-302530-pp6bl941 676 7 of of IN cord-302530-pp6bl941 676 8 the the DT cord-302530-pp6bl941 676 9 " " `` cord-302530-pp6bl941 676 10 proof proof NN cord-302530-pp6bl941 676 11 of of IN cord-302530-pp6bl941 676 12 concept concept NN cord-302530-pp6bl941 676 13 " " '' cord-302530-pp6bl941 676 14 model model NN cord-302530-pp6bl941 676 15 here here RB cord-302530-pp6bl941 676 16 that that IN cord-302530-pp6bl941 676 17 the the DT cord-302530-pp6bl941 676 18 thermodynamic thermodynamic JJ cord-302530-pp6bl941 676 19 parameters parameter NNS cord-302530-pp6bl941 676 20 for for IN cord-302530-pp6bl941 676 21 the the DT cord-302530-pp6bl941 676 22 HIV HIV NNP cord-302530-pp6bl941 676 23 gp120 gp120 NNP cord-302530-pp6bl941 676 24 monomer monomer NN cord-302530-pp6bl941 676 25 : : : cord-302530-pp6bl941 676 26 CD4 CD4 NNP cord-302530-pp6bl941 676 27 interaction interaction NN cord-302530-pp6bl941 676 28 in in IN cord-302530-pp6bl941 676 29 Myszka Myszka NNP cord-302530-pp6bl941 676 30 et et NNP cord-302530-pp6bl941 676 31 al al NNP cord-302530-pp6bl941 676 32 . . . cord-302530-pp6bl941 677 1 ( ( -LRB- cord-302530-pp6bl941 677 2 2000 2000 CD cord-302530-pp6bl941 677 3 ) ) -RRB- cord-302530-pp6bl941 677 4 can can MD cord-302530-pp6bl941 677 5 be be VB cord-302530-pp6bl941 677 6 used use VBN cord-302530-pp6bl941 677 7 for for IN cord-302530-pp6bl941 677 8 HIV HIV NNP cord-302530-pp6bl941 677 9 Env Env NNP cord-302530-pp6bl941 677 10 trimer trimer NN cord-302530-pp6bl941 677 11 binding bind VBG cord-302530-pp6bl941 677 12 to to IN cord-302530-pp6bl941 677 13 a a DT cord-302530-pp6bl941 677 14 single single JJ cord-302530-pp6bl941 677 15 CD4 CD4 NNP cord-302530-pp6bl941 677 16 in in IN cord-302530-pp6bl941 677 17 the the DT cord-302530-pp6bl941 677 18 absence absence NN cord-302530-pp6bl941 677 19 of of IN cord-302530-pp6bl941 677 20 data datum NNS cord-302530-pp6bl941 677 21 . . . cord-302530-pp6bl941 678 1 Although although IN cord-302530-pp6bl941 678 2 the the DT cord-302530-pp6bl941 678 3 K K NNP cord-302530-pp6bl941 678 4 d_receptor_T d_receptor_T NNP cord-302530-pp6bl941 678 5 value value NN cord-302530-pp6bl941 678 6 for for IN cord-302530-pp6bl941 678 7 the the DT cord-302530-pp6bl941 678 8 Env Env NNP cord-302530-pp6bl941 678 9 trimer trimer NN cord-302530-pp6bl941 678 10 : : : cord-302530-pp6bl941 678 11 CD4 CD4 NNP cord-302530-pp6bl941 678 12 interaction interaction NN cord-302530-pp6bl941 678 13 ( ( -LRB- cord-302530-pp6bl941 678 14 1.4 1.4 CD cord-302530-pp6bl941 678 15 × × NN cord-302530-pp6bl941 678 16 10 10 CD cord-302530-pp6bl941 678 17 −9 −9 NNP cord-302530-pp6bl941 678 18 M M NNP cord-302530-pp6bl941 678 19 , , , cord-302530-pp6bl941 678 20 Chuang Chuang NNP cord-302530-pp6bl941 678 21 et et NNP cord-302530-pp6bl941 678 22 al al NNP cord-302530-pp6bl941 678 23 . . NNP cord-302530-pp6bl941 678 24 , , , cord-302530-pp6bl941 678 25 2017 2017 CD cord-302530-pp6bl941 678 26 ) ) -RRB- cord-302530-pp6bl941 678 27 is be VBZ cord-302530-pp6bl941 678 28 15-fold 15-fold RB cord-302530-pp6bl941 678 29 higher high JJR cord-302530-pp6bl941 678 30 than than IN cord-302530-pp6bl941 678 31 that that DT cord-302530-pp6bl941 678 32 for for IN cord-302530-pp6bl941 678 33 the the DT cord-302530-pp6bl941 678 34 gp120 gp120 NNP cord-302530-pp6bl941 678 35 monomer monomer NN cord-302530-pp6bl941 678 36 : : : cord-302530-pp6bl941 679 1 CD4 CD4 NNP cord-302530-pp6bl941 679 2 interaction interaction NN cord-302530-pp6bl941 679 3 ( ( -LRB- cord-302530-pp6bl941 679 4 0.9 0.9 CD cord-302530-pp6bl941 679 5 × × NN cord-302530-pp6bl941 679 6 10 10 CD cord-302530-pp6bl941 679 7 −10 −10 NNP cord-302530-pp6bl941 679 8 M M NNP cord-302530-pp6bl941 679 9 , , , cord-302530-pp6bl941 679 10 Table Table NNP cord-302530-pp6bl941 679 11 4 4 CD cord-302530-pp6bl941 679 12 ) ) -RRB- cord-302530-pp6bl941 679 13 at at IN cord-302530-pp6bl941 679 14 25 25 CD cord-302530-pp6bl941 679 15 ° ° NN cord-302530-pp6bl941 679 16 C c NN cord-302530-pp6bl941 680 1 , , , cord-302530-pp6bl941 680 2 this this DT cord-302530-pp6bl941 680 3 is be VBZ cord-302530-pp6bl941 680 4 close close JJ cord-302530-pp6bl941 680 5 enough enough RB cord-302530-pp6bl941 680 6 to to TO cord-302530-pp6bl941 680 7 support support VB cord-302530-pp6bl941 680 8 using use VBG cord-302530-pp6bl941 680 9 the the DT cord-302530-pp6bl941 680 10 gp120 gp120 NNP cord-302530-pp6bl941 680 11 monomer monomer NN cord-302530-pp6bl941 680 12 : : : cord-302530-pp6bl941 681 1 CD4 CD4 NNP cord-302530-pp6bl941 681 2 data datum NNS cord-302530-pp6bl941 681 3 , , , cord-302530-pp6bl941 681 4 particularly particularly RB cord-302530-pp6bl941 681 5 as as IN cord-302530-pp6bl941 681 6 K K NNP cord-302530-pp6bl941 681 7 d_receptor_T d_receptor_t CD cord-302530-pp6bl941 681 8 values value NNS cord-302530-pp6bl941 681 9 for for IN cord-302530-pp6bl941 681 10 the the DT cord-302530-pp6bl941 681 11 gp120 gp120 NNP cord-302530-pp6bl941 681 12 monomer monomer NN cord-302530-pp6bl941 681 13 : : : cord-302530-pp6bl941 682 1 CD4 CD4 NNP cord-302530-pp6bl941 682 2 interaction interaction NN cord-302530-pp6bl941 682 3 vary vary VBP cord-302530-pp6bl941 682 4 nine nine CD cord-302530-pp6bl941 682 5 - - HYPH cord-302530-pp6bl941 682 6 fold fold NN cord-302530-pp6bl941 682 7 between between IN cord-302530-pp6bl941 682 8 two two CD cord-302530-pp6bl941 682 9 HIV HIV NNP cord-302530-pp6bl941 682 10 strains strain NNS cord-302530-pp6bl941 682 11 ( ( -LRB- cord-302530-pp6bl941 682 12 see see VB cord-302530-pp6bl941 682 13 above above RB cord-302530-pp6bl941 682 14 ) ) -RRB- cord-302530-pp6bl941 682 15 . . . cord-302530-pp6bl941 683 1 The the DT cord-302530-pp6bl941 683 2 predicted predict VBN cord-302530-pp6bl941 683 3 values value NNS cord-302530-pp6bl941 683 4 of of IN cord-302530-pp6bl941 683 5 K K NNP cord-302530-pp6bl941 683 6 a_virus_T a_virus_T NNP cord-302530-pp6bl941 683 7 increase increase NN cord-302530-pp6bl941 683 8 with with IN cord-302530-pp6bl941 683 9 decreasing decrease VBG cord-302530-pp6bl941 683 10 temperature temperature NN cord-302530-pp6bl941 683 11 according accord VBG cord-302530-pp6bl941 683 12 the the DT cord-302530-pp6bl941 683 13 HIV HIV NNP cord-302530-pp6bl941 683 14 model model NN cord-302530-pp6bl941 683 15 in in IN cord-302530-pp6bl941 683 16 Fig Fig NNP cord-302530-pp6bl941 683 17 . . . cord-302530-pp6bl941 684 1 5a 5a LS cord-302530-pp6bl941 684 2 . . . cord-302530-pp6bl941 685 1 This this DT cord-302530-pp6bl941 685 2 is be VBZ cord-302530-pp6bl941 685 3 unexpected unexpected JJ cord-302530-pp6bl941 685 4 on on IN cord-302530-pp6bl941 685 5 the the DT cord-302530-pp6bl941 685 6 basis basis NN cord-302530-pp6bl941 685 7 of of IN cord-302530-pp6bl941 685 8 the the DT cord-302530-pp6bl941 685 9 ΔH ΔH NNP cord-302530-pp6bl941 685 10 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 685 11 values value NNS cord-302530-pp6bl941 685 12 reported report VBN cord-302530-pp6bl941 685 13 by by IN cord-302530-pp6bl941 685 14 Myszka Myszka NNP cord-302530-pp6bl941 685 15 et et NNP cord-302530-pp6bl941 685 16 al al NNP cord-302530-pp6bl941 685 17 . . . cord-302530-pp6bl941 686 1 ( ( -LRB- cord-302530-pp6bl941 686 2 2000 2000 CD cord-302530-pp6bl941 686 3 ) ) -RRB- cord-302530-pp6bl941 687 1 for for IN cord-302530-pp6bl941 687 2 gp120 gp120 NNP cord-302530-pp6bl941 687 3 : : : cord-302530-pp6bl941 687 4 CD4 CD4 NNP cord-302530-pp6bl941 687 5 which which WDT cord-302530-pp6bl941 687 6 become become VBP cord-302530-pp6bl941 687 7 less less RBR cord-302530-pp6bl941 687 8 negative negative JJ cord-302530-pp6bl941 687 9 with with IN cord-302530-pp6bl941 687 10 decreasing decrease VBG cord-302530-pp6bl941 687 11 temperature temperature NN cord-302530-pp6bl941 687 12 ( ( -LRB- cord-302530-pp6bl941 687 13 Fig fig NN cord-302530-pp6bl941 687 14 . . . cord-302530-pp6bl941 687 15 1 1 CD cord-302530-pp6bl941 687 16 ) ) -RRB- cord-302530-pp6bl941 687 17 . . . cord-302530-pp6bl941 688 1 However however RB cord-302530-pp6bl941 688 2 , , , cord-302530-pp6bl941 688 3 according accord VBG cord-302530-pp6bl941 688 4 to to IN cord-302530-pp6bl941 688 5 Eq Eq NNP cord-302530-pp6bl941 688 6 . . . cord-302530-pp6bl941 689 1 ( ( -LRB- cord-302530-pp6bl941 689 2 6 6 CD cord-302530-pp6bl941 689 3 ) ) -RRB- cord-302530-pp6bl941 690 1 the the DT cord-302530-pp6bl941 690 2 predicted predict VBN cord-302530-pp6bl941 690 3 ΔS ΔS NNP cord-302530-pp6bl941 690 4 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 690 5 term term NN cord-302530-pp6bl941 690 6 becomes become VBZ cord-302530-pp6bl941 690 7 more more RBR cord-302530-pp6bl941 690 8 favourable favourable JJ cord-302530-pp6bl941 690 9 ( ( -LRB- cord-302530-pp6bl941 690 10 less less RBR cord-302530-pp6bl941 690 11 negative negative JJ cord-302530-pp6bl941 690 12 ) ) -RRB- cord-302530-pp6bl941 690 13 with with IN cord-302530-pp6bl941 690 14 decreasing decrease VBG cord-302530-pp6bl941 690 15 temperature temperature NN cord-302530-pp6bl941 690 16 and and CC cord-302530-pp6bl941 690 17 it -PRON- PRP cord-302530-pp6bl941 690 18 is be VBZ cord-302530-pp6bl941 690 19 therefore therefore RB cord-302530-pp6bl941 690 20 the the DT cord-302530-pp6bl941 690 21 entropy entropy NN cord-302530-pp6bl941 690 22 term term NN cord-302530-pp6bl941 690 23 that that WDT cord-302530-pp6bl941 690 24 facilitates facilitate VBZ cord-302530-pp6bl941 690 25 the the DT cord-302530-pp6bl941 690 26 tighter tight JJR cord-302530-pp6bl941 690 27 binding binding NN cord-302530-pp6bl941 690 28 of of IN cord-302530-pp6bl941 690 29 gp120 gp120 DT cord-302530-pp6bl941 690 30 to to IN cord-302530-pp6bl941 690 31 CD4 CD4 NNP cord-302530-pp6bl941 690 32 at at IN cord-302530-pp6bl941 690 33 lower low JJR cord-302530-pp6bl941 690 34 temperatures temperature NNS cord-302530-pp6bl941 690 35 . . . cord-302530-pp6bl941 691 1 Unfortunately unfortunately RB cord-302530-pp6bl941 691 2 Myszka Myszka NNP cord-302530-pp6bl941 691 3 et et NNP cord-302530-pp6bl941 691 4 al al NNP cord-302530-pp6bl941 691 5 . . . cord-302530-pp6bl941 692 1 ( ( -LRB- cord-302530-pp6bl941 692 2 2000 2000 CD cord-302530-pp6bl941 692 3 ) ) -RRB- cord-302530-pp6bl941 692 4 only only RB cord-302530-pp6bl941 692 5 give give VBP cord-302530-pp6bl941 692 6 the the DT cord-302530-pp6bl941 692 7 full full JJ cord-302530-pp6bl941 692 8 range range NN cord-302530-pp6bl941 692 9 of of IN cord-302530-pp6bl941 692 10 values value NNS cord-302530-pp6bl941 692 11 for for IN cord-302530-pp6bl941 692 12 ΔH ΔH NNP cord-302530-pp6bl941 692 13 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 693 1 ( ( -LRB- cord-302530-pp6bl941 693 2 Fig Fig NNP cord-302530-pp6bl941 693 3 . . . cord-302530-pp6bl941 693 4 1 1 CD cord-302530-pp6bl941 693 5 ) ) -RRB- cord-302530-pp6bl941 693 6 with with IN cord-302530-pp6bl941 693 7 no no DT cord-302530-pp6bl941 693 8 data data NN cord-302530-pp6bl941 693 9 for for IN cord-302530-pp6bl941 693 10 ΔS ΔS NNP cord-302530-pp6bl941 693 11 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 693 12 over over IN cord-302530-pp6bl941 693 13 the the DT cord-302530-pp6bl941 693 14 range range NN cord-302530-pp6bl941 693 15 of of IN cord-302530-pp6bl941 693 16 temperature temperature NN cord-302530-pp6bl941 693 17 . . . cord-302530-pp6bl941 694 1 However however RB cord-302530-pp6bl941 694 2 , , , cord-302530-pp6bl941 694 3 Myszka Myszka NNP cord-302530-pp6bl941 694 4 et et NNP cord-302530-pp6bl941 694 5 al al NNP cord-302530-pp6bl941 694 6 . . . cord-302530-pp6bl941 695 1 ( ( -LRB- cord-302530-pp6bl941 695 2 2000 2000 CD cord-302530-pp6bl941 695 3 ) ) -RRB- cord-302530-pp6bl941 695 4 do do VBP cord-302530-pp6bl941 695 5 give give VB cord-302530-pp6bl941 695 6 some some DT cord-302530-pp6bl941 695 7 graphical graphical JJ cord-302530-pp6bl941 695 8 data datum NNS cord-302530-pp6bl941 695 9 from from IN cord-302530-pp6bl941 695 10 which which WDT cord-302530-pp6bl941 695 11 ΔS ΔS NNP cord-302530-pp6bl941 695 12 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 695 13 at at IN cord-302530-pp6bl941 695 14 25 25 CD cord-302530-pp6bl941 695 15 ° ° NNS cord-302530-pp6bl941 696 1 C C NNP cord-302530-pp6bl941 696 2 can can MD cord-302530-pp6bl941 696 3 be be VB cord-302530-pp6bl941 696 4 estimated estimate VBN cord-302530-pp6bl941 696 5 and and CC cord-302530-pp6bl941 696 6 it -PRON- PRP cord-302530-pp6bl941 696 7 is be VBZ cord-302530-pp6bl941 696 8 reassuring reassure VBG cord-302530-pp6bl941 697 1 this this DT cord-302530-pp6bl941 697 2 ΔS ΔS NNP cord-302530-pp6bl941 698 1 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 698 2 is be VBZ cord-302530-pp6bl941 698 3 much much RB cord-302530-pp6bl941 698 4 less less RBR cord-302530-pp6bl941 698 5 negative negative JJ cord-302530-pp6bl941 698 6 at at IN cord-302530-pp6bl941 698 7 −473 −473 NNP cord-302530-pp6bl941 698 8 J J NNP cord-302530-pp6bl941 698 9 / / SYM cord-302530-pp6bl941 698 10 mol mol NNP cord-302530-pp6bl941 698 11 / / SYM cord-302530-pp6bl941 698 12 K K NNP cord-302530-pp6bl941 698 13 than than IN cord-302530-pp6bl941 698 14 that that DT cord-302530-pp6bl941 698 15 of of IN cord-302530-pp6bl941 698 16 −691 −691 NNP cord-302530-pp6bl941 698 17 J J NNP cord-302530-pp6bl941 698 18 / / SYM cord-302530-pp6bl941 698 19 mol mol NNP cord-302530-pp6bl941 698 20 / / SYM cord-302530-pp6bl941 698 21 K K NNP cord-302530-pp6bl941 699 1 measured measure VBN cord-302530-pp6bl941 699 2 at at IN cord-302530-pp6bl941 699 3 37 37 CD cord-302530-pp6bl941 699 4 ° ° NN cord-302530-pp6bl941 699 5 C c NN cord-302530-pp6bl941 699 6 and and CC cord-302530-pp6bl941 699 7 furthermore furthermore RB cord-302530-pp6bl941 699 8 is be VBZ cord-302530-pp6bl941 699 9 actually actually RB cord-302530-pp6bl941 699 10 less less RBR cord-302530-pp6bl941 699 11 negative negative JJ cord-302530-pp6bl941 699 12 than than IN cord-302530-pp6bl941 699 13 the the DT cord-302530-pp6bl941 699 14 value value NN cord-302530-pp6bl941 699 15 of of IN cord-302530-pp6bl941 699 16 −492.8 −492.8 NNP cord-302530-pp6bl941 699 17 J J NNP cord-302530-pp6bl941 699 18 / / SYM cord-302530-pp6bl941 699 19 mol mol NNP cord-302530-pp6bl941 699 20 / / SYM cord-302530-pp6bl941 699 21 K K NNP cord-302530-pp6bl941 699 22 predicted predict VBD cord-302530-pp6bl941 699 23 for for IN cord-302530-pp6bl941 699 24 25 25 CD cord-302530-pp6bl941 699 25 ° ° NN cord-302530-pp6bl941 699 26 C c NN cord-302530-pp6bl941 699 27 by by IN cord-302530-pp6bl941 699 28 Eq Eq NNP cord-302530-pp6bl941 699 29 . . . cord-302530-pp6bl941 700 1 ( ( -LRB- cord-302530-pp6bl941 700 2 6 6 LS cord-302530-pp6bl941 700 3 ) ) -RRB- cord-302530-pp6bl941 700 4 ( ( -LRB- cord-302530-pp6bl941 700 5 Table table NN cord-302530-pp6bl941 700 6 4 4 CD cord-302530-pp6bl941 700 7 ) ) -RRB- cord-302530-pp6bl941 700 8 and and CC cord-302530-pp6bl941 700 9 used use VBN cord-302530-pp6bl941 700 10 in in IN cord-302530-pp6bl941 700 11 the the DT cord-302530-pp6bl941 700 12 model model NN cord-302530-pp6bl941 700 13 in in IN cord-302530-pp6bl941 700 14 Fig Fig NNP cord-302530-pp6bl941 700 15 . . . cord-302530-pp6bl941 701 1 5 5 LS cord-302530-pp6bl941 701 2 . . . cord-302530-pp6bl941 702 1 This this DT cord-302530-pp6bl941 702 2 is be VBZ cord-302530-pp6bl941 702 3 strong strong JJ cord-302530-pp6bl941 702 4 experimental experimental JJ cord-302530-pp6bl941 702 5 evidence evidence NN cord-302530-pp6bl941 702 6 that that IN cord-302530-pp6bl941 702 7 warming warm VBG cord-302530-pp6bl941 702 8 to to IN cord-302530-pp6bl941 702 9 37 37 CD cord-302530-pp6bl941 702 10 ° ° NN cord-302530-pp6bl941 702 11 C c NN cord-302530-pp6bl941 702 12 and and CC cord-302530-pp6bl941 702 13 above above RB cord-302530-pp6bl941 702 14 does do VBZ cord-302530-pp6bl941 702 15 indeed indeed RB cord-302530-pp6bl941 702 16 give give VB cord-302530-pp6bl941 702 17 a a DT cord-302530-pp6bl941 702 18 significant significant JJ cord-302530-pp6bl941 702 19 reduction reduction NN cord-302530-pp6bl941 702 20 in in IN cord-302530-pp6bl941 702 21 the the DT cord-302530-pp6bl941 702 22 binding bind VBG cord-302530-pp6bl941 702 23 affinity affinity NN cord-302530-pp6bl941 702 24 of of IN cord-302530-pp6bl941 702 25 Env Env NNP cord-302530-pp6bl941 702 26 to to IN cord-302530-pp6bl941 702 27 CD4 CD4 NNP cord-302530-pp6bl941 702 28 as as IN cord-302530-pp6bl941 702 29 borne bear VBN cord-302530-pp6bl941 702 30 out out RP cord-302530-pp6bl941 702 31 by by IN cord-302530-pp6bl941 702 32 the the DT cord-302530-pp6bl941 702 33 52-fold 52-fold CD cord-302530-pp6bl941 702 34 increase increase NN cord-302530-pp6bl941 702 35 in in IN cord-302530-pp6bl941 702 36 the the DT cord-302530-pp6bl941 702 37 K K NNP cord-302530-pp6bl941 702 38 d_receptor_T d_receptor_T NNP cord-302530-pp6bl941 702 39 value value NN cord-302530-pp6bl941 702 40 for for IN cord-302530-pp6bl941 702 41 gp120 gp120 NN cord-302530-pp6bl941 702 42 : : : cord-302530-pp6bl941 703 1 CD4 CD4 NNP cord-302530-pp6bl941 703 2 on on IN cord-302530-pp6bl941 703 3 warming warm VBG cord-302530-pp6bl941 703 4 from from IN cord-302530-pp6bl941 703 5 25 25 CD cord-302530-pp6bl941 703 6 ° ° NN cord-302530-pp6bl941 703 7 C c NN cord-302530-pp6bl941 703 8 to to IN cord-302530-pp6bl941 703 9 37 37 CD cord-302530-pp6bl941 703 10 ° ° NN cord-302530-pp6bl941 703 11 C c NN cord-302530-pp6bl941 703 12 as as IN cord-302530-pp6bl941 703 13 calculated calculate VBN cord-302530-pp6bl941 703 14 from from IN cord-302530-pp6bl941 703 15 the the DT cord-302530-pp6bl941 703 16 actual actual JJ cord-302530-pp6bl941 703 17 data datum NNS cord-302530-pp6bl941 703 18 of of IN cord-302530-pp6bl941 703 19 Myszka Myszka NNP cord-302530-pp6bl941 703 20 et et NNP cord-302530-pp6bl941 703 21 al al NNP cord-302530-pp6bl941 703 22 . . . cord-302530-pp6bl941 704 1 ( ( -LRB- cord-302530-pp6bl941 704 2 2000 2000 CD cord-302530-pp6bl941 704 3 ) ) -RRB- cord-302530-pp6bl941 705 1 ( ( -LRB- cord-302530-pp6bl941 705 2 Table table NN cord-302530-pp6bl941 705 3 4 4 CD cord-302530-pp6bl941 705 4 ) ) -RRB- cord-302530-pp6bl941 705 5 . . . cord-302530-pp6bl941 706 1 Furthermore furthermore RB cord-302530-pp6bl941 706 2 it -PRON- PRP cord-302530-pp6bl941 706 3 suggests suggest VBZ cord-302530-pp6bl941 706 4 that that IN cord-302530-pp6bl941 706 5 the the DT cord-302530-pp6bl941 706 6 actual actual JJ cord-302530-pp6bl941 706 7 increase increase NN cord-302530-pp6bl941 706 8 in in IN cord-302530-pp6bl941 706 9 K K NNP cord-302530-pp6bl941 706 10 a_virus_T a_virus_T NNP cord-302530-pp6bl941 706 11 on on IN cord-302530-pp6bl941 706 12 cooling cool VBG cord-302530-pp6bl941 706 13 from from IN cord-302530-pp6bl941 706 14 37 37 CD cord-302530-pp6bl941 706 15 ° ° NN cord-302530-pp6bl941 706 16 C c NN cord-302530-pp6bl941 706 17 down down RB cord-302530-pp6bl941 706 18 to to IN cord-302530-pp6bl941 706 19 25 25 CD cord-302530-pp6bl941 706 20 ° ° NN cord-302530-pp6bl941 706 21 C c NN cord-302530-pp6bl941 706 22 may may MD cord-302530-pp6bl941 706 23 be be VB cord-302530-pp6bl941 706 24 greater great JJR cord-302530-pp6bl941 706 25 than than IN cord-302530-pp6bl941 706 26 that that DT cord-302530-pp6bl941 706 27 predicted predict VBN cord-302530-pp6bl941 706 28 by by IN cord-302530-pp6bl941 706 29 the the DT cord-302530-pp6bl941 706 30 model model NN cord-302530-pp6bl941 706 31 in in IN cord-302530-pp6bl941 706 32 Fig Fig NNP cord-302530-pp6bl941 706 33 . . . cord-302530-pp6bl941 707 1 5a 5a LS cord-302530-pp6bl941 707 2 . . . cord-302530-pp6bl941 708 1 The the DT cord-302530-pp6bl941 708 2 decrease decrease NN cord-302530-pp6bl941 708 3 in in IN cord-302530-pp6bl941 708 4 binding bind VBG cord-302530-pp6bl941 708 5 affinity affinity NN cord-302530-pp6bl941 708 6 with with IN cord-302530-pp6bl941 708 7 increasing increase VBG cord-302530-pp6bl941 708 8 temperature temperature NN cord-302530-pp6bl941 708 9 for for IN cord-302530-pp6bl941 708 10 HIV HIV NNP cord-302530-pp6bl941 708 11 Env Env NNP cord-302530-pp6bl941 708 12 : : : cord-302530-pp6bl941 708 13 CD4 CD4 NNP cord-302530-pp6bl941 708 14 is be VBZ cord-302530-pp6bl941 708 15 also also RB cord-302530-pp6bl941 708 16 supported support VBN cord-302530-pp6bl941 708 17 by by IN cord-302530-pp6bl941 708 18 experimental experimental JJ cord-302530-pp6bl941 708 19 data datum NNS cord-302530-pp6bl941 708 20 of of IN cord-302530-pp6bl941 708 21 Moore Moore NNP cord-302530-pp6bl941 708 22 and and CC cord-302530-pp6bl941 708 23 Klasse Klasse NNP cord-302530-pp6bl941 708 24 ( ( -LRB- cord-302530-pp6bl941 708 25 1992 1992 CD cord-302530-pp6bl941 708 26 ) ) -RRB- cord-302530-pp6bl941 708 27 which which WDT cord-302530-pp6bl941 708 28 showed show VBD cord-302530-pp6bl941 708 29 that that IN cord-302530-pp6bl941 708 30 soluble soluble JJ cord-302530-pp6bl941 708 31 CD4 CD4 NNP cord-302530-pp6bl941 708 32 dissociated dissociate VBD cord-302530-pp6bl941 708 33 from from IN cord-302530-pp6bl941 708 34 HIV HIV NNP cord-302530-pp6bl941 708 35 virions virion NNS cord-302530-pp6bl941 708 36 at at IN cord-302530-pp6bl941 708 37 temperatures temperature NNS cord-302530-pp6bl941 708 38 above above IN cord-302530-pp6bl941 708 39 35 35 CD cord-302530-pp6bl941 708 40 ° ° NN cord-302530-pp6bl941 708 41 C c NN cord-302530-pp6bl941 708 42 . . . cord-302530-pp6bl941 709 1 Similarly similarly RB cord-302530-pp6bl941 709 2 Doranz Doranz NNP cord-302530-pp6bl941 709 3 et et NNP cord-302530-pp6bl941 709 4 al al NNP cord-302530-pp6bl941 709 5 . . . cord-302530-pp6bl941 710 1 ( ( -LRB- cord-302530-pp6bl941 710 2 1999 1999 CD cord-302530-pp6bl941 710 3 ) ) -RRB- cord-302530-pp6bl941 710 4 demonstrated demonstrate VBD cord-302530-pp6bl941 710 5 that that IN cord-302530-pp6bl941 710 6 gp120 gp120 DT cord-302530-pp6bl941 710 7 bound bind VBN cord-302530-pp6bl941 710 8 to to IN cord-302530-pp6bl941 710 9 CD4 CD4 NNP cord-302530-pp6bl941 710 10 + + CC cord-302530-pp6bl941 710 11 T t NN cord-302530-pp6bl941 710 12 cells cell NNS cord-302530-pp6bl941 710 13 began begin VBD cord-302530-pp6bl941 710 14 to to TO cord-302530-pp6bl941 710 15 dissociate dissociate VB cord-302530-pp6bl941 710 16 at at IN cord-302530-pp6bl941 710 17 temperatures temperature NNS cord-302530-pp6bl941 710 18 above above IN cord-302530-pp6bl941 710 19 45 45 CD cord-302530-pp6bl941 710 20 ° ° NN cord-302530-pp6bl941 710 21 C c NN cord-302530-pp6bl941 710 22 . . . cord-302530-pp6bl941 711 1 The the DT cord-302530-pp6bl941 711 2 data datum NNS cord-302530-pp6bl941 711 3 of of IN cord-302530-pp6bl941 711 4 Frey Frey NNP cord-302530-pp6bl941 711 5 et et NNP cord-302530-pp6bl941 711 6 al al NNP cord-302530-pp6bl941 711 7 . . . cord-302530-pp6bl941 712 1 ( ( -LRB- cord-302530-pp6bl941 712 2 1995 1995 CD cord-302530-pp6bl941 712 3 ) ) -RRB- cord-302530-pp6bl941 712 4 in in IN cord-302530-pp6bl941 712 5 Fig Fig NNP cord-302530-pp6bl941 712 6 . . . cord-302530-pp6bl941 713 1 6 6 CD cord-302530-pp6bl941 713 2 offer offer VBP cord-302530-pp6bl941 713 3 further further JJ cord-302530-pp6bl941 713 4 validation validation NN cord-302530-pp6bl941 713 5 of of IN cord-302530-pp6bl941 713 6 the the DT cord-302530-pp6bl941 713 7 model model NN cord-302530-pp6bl941 713 8 in in IN cord-302530-pp6bl941 713 9 that that IN cord-302530-pp6bl941 713 10 the the DT cord-302530-pp6bl941 713 11 binding binding NN cord-302530-pp6bl941 713 12 of of IN cord-302530-pp6bl941 713 13 HIV HIV NNP cord-302530-pp6bl941 713 14 Env Env NNP cord-302530-pp6bl941 713 15 - - HYPH cord-302530-pp6bl941 713 16 expressing express VBG cord-302530-pp6bl941 713 17 cells cell NNS cord-302530-pp6bl941 713 18 to to IN cord-302530-pp6bl941 713 19 cells cell NNS cord-302530-pp6bl941 713 20 expressing express VBG cord-302530-pp6bl941 713 21 CD4 CD4 NNP cord-302530-pp6bl941 713 22 decreases decrease VBZ cord-302530-pp6bl941 713 23 substantially substantially RB cord-302530-pp6bl941 713 24 at at IN cord-302530-pp6bl941 713 25 37 37 CD cord-302530-pp6bl941 713 26 ° ° NN cord-302530-pp6bl941 713 27 C c NN cord-302530-pp6bl941 713 28 as as IN cord-302530-pp6bl941 713 29 predicted predict VBN cord-302530-pp6bl941 713 30 by by IN cord-302530-pp6bl941 713 31 the the DT cord-302530-pp6bl941 713 32 model model NN cord-302530-pp6bl941 713 33 . . . cord-302530-pp6bl941 714 1 The the DT cord-302530-pp6bl941 714 2 Env Env NNP cord-302530-pp6bl941 714 3 trimer trimer NN cord-302530-pp6bl941 714 4 is be VBZ cord-302530-pp6bl941 714 5 stable stable JJ cord-302530-pp6bl941 714 6 up up IN cord-302530-pp6bl941 714 7 to to IN cord-302530-pp6bl941 714 8 at at RB cord-302530-pp6bl941 714 9 least least RBS cord-302530-pp6bl941 714 10 60 60 CD cord-302530-pp6bl941 714 11 ° ° NN cord-302530-pp6bl941 714 12 C c NN cord-302530-pp6bl941 714 13 ( ( -LRB- cord-302530-pp6bl941 714 14 Chuang Chuang NNP cord-302530-pp6bl941 714 15 et et NNP cord-302530-pp6bl941 714 16 al al NNP cord-302530-pp6bl941 714 17 . . NNP cord-302530-pp6bl941 714 18 , , , cord-302530-pp6bl941 714 19 2017 2017 CD cord-302530-pp6bl941 714 20 ) ) -RRB- cord-302530-pp6bl941 714 21 suggesting suggest VBG cord-302530-pp6bl941 714 22 it -PRON- PRP cord-302530-pp6bl941 714 23 is be VBZ cord-302530-pp6bl941 714 24 not not RB cord-302530-pp6bl941 714 25 denaturation denaturation NN cord-302530-pp6bl941 714 26 of of IN cord-302530-pp6bl941 714 27 the the DT cord-302530-pp6bl941 714 28 Env Env NNP cord-302530-pp6bl941 714 29 trimer trimer NN cord-302530-pp6bl941 714 30 itself -PRON- PRP cord-302530-pp6bl941 714 31 that that WDT cord-302530-pp6bl941 714 32 is be VBZ cord-302530-pp6bl941 714 33 responsible responsible JJ cord-302530-pp6bl941 714 34 for for IN cord-302530-pp6bl941 714 35 the the DT cord-302530-pp6bl941 714 36 decreased decrease VBN cord-302530-pp6bl941 714 37 binding bind VBG cord-302530-pp6bl941 714 38 at at IN cord-302530-pp6bl941 714 39 higher high JJR cord-302530-pp6bl941 714 40 temperatures temperature NNS cord-302530-pp6bl941 714 41 . . . cord-302530-pp6bl941 715 1 However however RB cord-302530-pp6bl941 715 2 , , , cord-302530-pp6bl941 715 3 care care NN cord-302530-pp6bl941 715 4 has have VBZ cord-302530-pp6bl941 715 5 to to TO cord-302530-pp6bl941 715 6 be be VB cord-302530-pp6bl941 715 7 taken take VBN cord-302530-pp6bl941 715 8 in in IN cord-302530-pp6bl941 715 9 using use VBG cord-302530-pp6bl941 715 10 Eqs Eqs NNP cord-302530-pp6bl941 715 11 . . . cord-302530-pp6bl941 716 1 ( ( -LRB- cord-302530-pp6bl941 716 2 4 4 LS cord-302530-pp6bl941 716 3 ) ) -RRB- cord-302530-pp6bl941 716 4 and and CC cord-302530-pp6bl941 716 5 ( ( -LRB- cord-302530-pp6bl941 716 6 6 6 CD cord-302530-pp6bl941 716 7 ) ) -RRB- cord-302530-pp6bl941 717 1 to to TO cord-302530-pp6bl941 717 2 predict predict VB cord-302530-pp6bl941 717 3 ΔH ΔH NNP cord-302530-pp6bl941 717 4 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 717 5 and and CC cord-302530-pp6bl941 717 6 ΔS ΔS NNP cord-302530-pp6bl941 717 7 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 717 8 respectively respectively RB cord-302530-pp6bl941 717 9 down down RB cord-302530-pp6bl941 717 10 to to IN cord-302530-pp6bl941 717 11 very very RB cord-302530-pp6bl941 717 12 low low JJ cord-302530-pp6bl941 717 13 temperatures temperature NNS cord-302530-pp6bl941 717 14 . . . cord-302530-pp6bl941 718 1 Thus thus RB cord-302530-pp6bl941 718 2 although although IN cord-302530-pp6bl941 718 3 the the DT cord-302530-pp6bl941 718 4 predicted predict VBN cord-302530-pp6bl941 718 5 value value NN cord-302530-pp6bl941 718 6 of of IN cord-302530-pp6bl941 718 7 K K NNP cord-302530-pp6bl941 718 8 d_receptor_T d_receptor_T NNP cord-302530-pp6bl941 718 9 for for IN cord-302530-pp6bl941 718 10 gp120 gp120 NNP cord-302530-pp6bl941 718 11 : : : cord-302530-pp6bl941 718 12 CD4 CD4 NNP cord-302530-pp6bl941 718 13 at at IN cord-302530-pp6bl941 718 14 4 4 CD cord-302530-pp6bl941 718 15 ° ° NN cord-302530-pp6bl941 718 16 C c NN cord-302530-pp6bl941 718 17 is be VBZ cord-302530-pp6bl941 718 18 3700-fold 3700-fold CD cord-302530-pp6bl941 718 19 lower low JJR cord-302530-pp6bl941 718 20 than than IN cord-302530-pp6bl941 718 21 that that DT cord-302530-pp6bl941 718 22 at at IN cord-302530-pp6bl941 718 23 37 37 CD cord-302530-pp6bl941 718 24 ° ° NN cord-302530-pp6bl941 718 25 C c NN cord-302530-pp6bl941 718 26 ( ( -LRB- cord-302530-pp6bl941 718 27 Table Table NNP cord-302530-pp6bl941 718 28 4 4 CD cord-302530-pp6bl941 718 29 ) ) -RRB- cord-302530-pp6bl941 718 30 , , , cord-302530-pp6bl941 718 31 Frey Frey NNP cord-302530-pp6bl941 718 32 et et NNP cord-302530-pp6bl941 718 33 al al NNP cord-302530-pp6bl941 718 34 . . . cord-302530-pp6bl941 719 1 ( ( -LRB- cord-302530-pp6bl941 719 2 1995 1995 CD cord-302530-pp6bl941 719 3 ) ) -RRB- cord-302530-pp6bl941 719 4 cite cite VBP cord-302530-pp6bl941 719 5 some some DT cord-302530-pp6bl941 719 6 studies study NNS cord-302530-pp6bl941 719 7 which which WDT cord-302530-pp6bl941 719 8 suggested suggest VBD cord-302530-pp6bl941 719 9 weaker weak JJR cord-302530-pp6bl941 719 10 binding binding NN cord-302530-pp6bl941 719 11 of of IN cord-302530-pp6bl941 719 12 soluble soluble JJ cord-302530-pp6bl941 719 13 CD4 CD4 NNP cord-302530-pp6bl941 719 14 to to IN cord-302530-pp6bl941 719 15 HIV HIV NNP cord-302530-pp6bl941 719 16 virions virion NNS cord-302530-pp6bl941 719 17 at at IN cord-302530-pp6bl941 719 18 4 4 CD cord-302530-pp6bl941 719 19 ° ° NN cord-302530-pp6bl941 719 20 C c NN cord-302530-pp6bl941 719 21 compared compare VBN cord-302530-pp6bl941 719 22 to to IN cord-302530-pp6bl941 719 23 37 37 CD cord-302530-pp6bl941 719 24 ° ° NN cord-302530-pp6bl941 719 25 C c NN cord-302530-pp6bl941 719 26 . . . cord-302530-pp6bl941 720 1 Without without IN cord-302530-pp6bl941 720 2 actual actual JJ cord-302530-pp6bl941 720 3 binding bind VBG cord-302530-pp6bl941 720 4 data datum NNS cord-302530-pp6bl941 720 5 for for IN cord-302530-pp6bl941 720 6 HIV HIV NNP cord-302530-pp6bl941 720 7 over over IN cord-302530-pp6bl941 720 8 the the DT cord-302530-pp6bl941 720 9 full full JJ cord-302530-pp6bl941 720 10 temperature temperature NN cord-302530-pp6bl941 720 11 range range NN cord-302530-pp6bl941 720 12 , , , cord-302530-pp6bl941 720 13 it -PRON- PRP cord-302530-pp6bl941 720 14 can can MD cord-302530-pp6bl941 720 15 not not RB cord-302530-pp6bl941 720 16 be be VB cord-302530-pp6bl941 720 17 ruled rule VBN cord-302530-pp6bl941 720 18 out out RP cord-302530-pp6bl941 720 19 that that IN cord-302530-pp6bl941 720 20 K K NNP cord-302530-pp6bl941 720 21 a_virus_T a_virus_T NNP cord-302530-pp6bl941 720 22 does do VBZ cord-302530-pp6bl941 720 23 not not RB cord-302530-pp6bl941 720 24 exhibit exhibit VB cord-302530-pp6bl941 720 25 a a DT cord-302530-pp6bl941 720 26 peak peak NN cord-302530-pp6bl941 720 27 with with IN cord-302530-pp6bl941 720 28 temperature temperature NN cord-302530-pp6bl941 720 29 as as IN cord-302530-pp6bl941 720 30 for for IN cord-302530-pp6bl941 720 31 the the DT cord-302530-pp6bl941 720 32 WEEV weev NN cord-302530-pp6bl941 720 33 binding bind VBG cord-302530-pp6bl941 720 34 in in IN cord-302530-pp6bl941 720 35 Fig Fig NNP cord-302530-pp6bl941 720 36 . . . cord-302530-pp6bl941 720 37 3b 3b CD cord-302530-pp6bl941 720 38 . . . cord-302530-pp6bl941 721 1 Indeed indeed RB cord-302530-pp6bl941 721 2 , , , cord-302530-pp6bl941 721 3 binding bind VBG cord-302530-pp6bl941 721 4 of of IN cord-302530-pp6bl941 721 5 125 125 CD cord-302530-pp6bl941 721 6 Ilabelled ilabelled JJ cord-302530-pp6bl941 721 7 gp120 gp120 NNP cord-302530-pp6bl941 721 8 to to IN cord-302530-pp6bl941 721 9 T t NN cord-302530-pp6bl941 721 10 cells cell NNS cord-302530-pp6bl941 721 11 peaked peak VBD cord-302530-pp6bl941 721 12 at at IN cord-302530-pp6bl941 721 13 16 16 CD cord-302530-pp6bl941 721 14 ° ° NN cord-302530-pp6bl941 721 15 C c NN cord-302530-pp6bl941 721 16 with with IN cord-302530-pp6bl941 721 17 binding bind VBG cord-302530-pp6bl941 721 18 at at IN cord-302530-pp6bl941 721 19 4 4 CD cord-302530-pp6bl941 721 20 ° ° NN cord-302530-pp6bl941 721 21 C c NN cord-302530-pp6bl941 721 22 much much RB cord-302530-pp6bl941 721 23 lower low JJR cord-302530-pp6bl941 721 24 than than IN cord-302530-pp6bl941 721 25 that that DT cord-302530-pp6bl941 721 26 at at IN cord-302530-pp6bl941 721 27 37 37 CD cord-302530-pp6bl941 721 28 ° ° NN cord-302530-pp6bl941 721 29 C c NN cord-302530-pp6bl941 721 30 ( ( -LRB- cord-302530-pp6bl941 721 31 Frey Frey NNP cord-302530-pp6bl941 721 32 et et NNP cord-302530-pp6bl941 721 33 al al NNP cord-302530-pp6bl941 721 34 . . NNP cord-302530-pp6bl941 721 35 , , , cord-302530-pp6bl941 721 36 1995 1995 CD cord-302530-pp6bl941 721 37 ) ) -RRB- cord-302530-pp6bl941 721 38 . . . cord-302530-pp6bl941 722 1 The the DT cord-302530-pp6bl941 722 2 observed observed JJ cord-302530-pp6bl941 722 3 increase increase NN cord-302530-pp6bl941 722 4 between between IN cord-302530-pp6bl941 722 5 4 4 CD cord-302530-pp6bl941 722 6 ° ° NN cord-302530-pp6bl941 722 7 C c NN cord-302530-pp6bl941 722 8 and and CC cord-302530-pp6bl941 722 9 16 16 CD cord-302530-pp6bl941 722 10 ° ° NN cord-302530-pp6bl941 722 11 C C NNP cord-302530-pp6bl941 722 12 is be VBZ cord-302530-pp6bl941 722 13 unlikely unlikely JJ cord-302530-pp6bl941 722 14 to to TO cord-302530-pp6bl941 722 15 be be VB cord-302530-pp6bl941 722 16 due due JJ cord-302530-pp6bl941 722 17 to to IN cord-302530-pp6bl941 722 18 increased increase VBN cord-302530-pp6bl941 722 19 fluidity fluidity NN cord-302530-pp6bl941 722 20 of of IN cord-302530-pp6bl941 722 21 the the DT cord-302530-pp6bl941 722 22 membrane membrane NN cord-302530-pp6bl941 722 23 allowing allow VBG cord-302530-pp6bl941 722 24 recruitment recruitment NN cord-302530-pp6bl941 722 25 of of IN cord-302530-pp6bl941 722 26 more more JJR cord-302530-pp6bl941 722 27 CD4 CD4 NNP cord-302530-pp6bl941 722 28 molecules molecule NNS cord-302530-pp6bl941 722 29 because because IN cord-302530-pp6bl941 722 30 unlike unlike IN cord-302530-pp6bl941 722 31 the the DT cord-302530-pp6bl941 722 32 virus virus NN cord-302530-pp6bl941 722 33 , , , cord-302530-pp6bl941 722 34 each each DT cord-302530-pp6bl941 722 35 gp120 gp120 NN cord-302530-pp6bl941 722 36 only only RB cord-302530-pp6bl941 722 37 binds bind VBZ cord-302530-pp6bl941 722 38 a a DT cord-302530-pp6bl941 722 39 single single JJ cord-302530-pp6bl941 722 40 Cr cr NN cord-302530-pp6bl941 722 41 molecule molecule NN cord-302530-pp6bl941 722 42 . . . cord-302530-pp6bl941 723 1 Dimitrov Dimitrov NNP cord-302530-pp6bl941 723 2 et et NNP cord-302530-pp6bl941 723 3 al al NNP cord-302530-pp6bl941 723 4 . . . cord-302530-pp6bl941 724 1 ( ( -LRB- cord-302530-pp6bl941 724 2 1992 1992 CD cord-302530-pp6bl941 724 3 ) ) -RRB- cord-302530-pp6bl941 724 4 showed show VBD cord-302530-pp6bl941 724 5 that that IN cord-302530-pp6bl941 724 6 the the DT cord-302530-pp6bl941 724 7 activation activation NN cord-302530-pp6bl941 724 8 energy energy NN cord-302530-pp6bl941 724 9 for for IN cord-302530-pp6bl941 724 10 binding bind VBG cord-302530-pp6bl941 724 11 of of IN cord-302530-pp6bl941 724 12 soluble soluble JJ cord-302530-pp6bl941 724 13 CD4 CD4 NNP cord-302530-pp6bl941 724 14 to to TO cord-302530-pp6bl941 724 15 cells cell NNS cord-302530-pp6bl941 724 16 expressing express VBG cord-302530-pp6bl941 724 17 HIV HIV NNP cord-302530-pp6bl941 724 18 Env Env NNP cord-302530-pp6bl941 724 19 changed change VBD cord-302530-pp6bl941 724 20 at at IN cord-302530-pp6bl941 724 21 18 18 CD cord-302530-pp6bl941 724 22 ° ° NN cord-302530-pp6bl941 724 23 C C NNP cord-302530-pp6bl941 724 24 suggesting suggest VBG cord-302530-pp6bl941 724 25 18 18 CD cord-302530-pp6bl941 724 26 ° ° NN cord-302530-pp6bl941 724 27 C C NNP cord-302530-pp6bl941 724 28 is be VBZ cord-302530-pp6bl941 724 29 a a DT cord-302530-pp6bl941 724 30 transition transition NN cord-302530-pp6bl941 724 31 temperature temperature NN cord-302530-pp6bl941 724 32 . . . cord-302530-pp6bl941 725 1 This this DT cord-302530-pp6bl941 725 2 could could MD cord-302530-pp6bl941 725 3 explain explain VB cord-302530-pp6bl941 725 4 the the DT cord-302530-pp6bl941 725 5 peak peak NN cord-302530-pp6bl941 725 6 in in IN cord-302530-pp6bl941 725 7 binding binding NN cord-302530-pp6bl941 725 8 of of IN cord-302530-pp6bl941 725 9 gp120 gp120 DT cord-302530-pp6bl941 725 10 at at IN cord-302530-pp6bl941 725 11 16 16 CD cord-302530-pp6bl941 725 12 ° ° NN cord-302530-pp6bl941 725 13 C C NNP cord-302530-pp6bl941 725 14 reported report VBN cord-302530-pp6bl941 725 15 by by IN cord-302530-pp6bl941 725 16 Frey Frey NNP cord-302530-pp6bl941 725 17 et et NNP cord-302530-pp6bl941 725 18 al al NNP cord-302530-pp6bl941 725 19 . . . cord-302530-pp6bl941 726 1 ( ( -LRB- cord-302530-pp6bl941 726 2 1995 1995 CD cord-302530-pp6bl941 726 3 ) ) -RRB- cord-302530-pp6bl941 726 4 . . . cord-302530-pp6bl941 727 1 Thus thus RB cord-302530-pp6bl941 727 2 extrapolation extrapolation NN cord-302530-pp6bl941 727 3 of of IN cord-302530-pp6bl941 727 4 ΔH ΔH NNP cord-302530-pp6bl941 727 5 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 727 6 and and CC cord-302530-pp6bl941 727 7 ΔS ΔS NNP cord-302530-pp6bl941 727 8 a_receptor_T a_receptor_T NNP cord-302530-pp6bl941 727 9 through through IN cord-302530-pp6bl941 727 10 Eqs Eqs NNP cord-302530-pp6bl941 727 11 . . . cord-302530-pp6bl941 728 1 ( ( -LRB- cord-302530-pp6bl941 728 2 4 4 LS cord-302530-pp6bl941 728 3 ) ) -RRB- cord-302530-pp6bl941 728 4 and and CC cord-302530-pp6bl941 728 5 ( ( -LRB- cord-302530-pp6bl941 728 6 6 6 CD cord-302530-pp6bl941 728 7 ) ) -RRB- cord-302530-pp6bl941 728 8 , , , cord-302530-pp6bl941 728 9 respectively respectively RB cord-302530-pp6bl941 728 10 to to IN cord-302530-pp6bl941 728 11 temperatures temperature NNS cord-302530-pp6bl941 728 12 below below IN cord-302530-pp6bl941 728 13 18 18 CD cord-302530-pp6bl941 728 14 ° ° NN cord-302530-pp6bl941 728 15 C c NN cord-302530-pp6bl941 728 16 may may MD cord-302530-pp6bl941 728 17 not not RB cord-302530-pp6bl941 728 18 be be VB cord-302530-pp6bl941 728 19 justified justify VBN cord-302530-pp6bl941 728 20 in in IN cord-302530-pp6bl941 728 21 the the DT cord-302530-pp6bl941 728 22 case case NN cord-302530-pp6bl941 728 23 of of IN cord-302530-pp6bl941 728 24 HIV HIV NNP cord-302530-pp6bl941 728 25 binding bind VBG cord-302530-pp6bl941 728 26 . . . cord-302530-pp6bl941 729 1 It -PRON- PRP cord-302530-pp6bl941 729 2 should should MD cord-302530-pp6bl941 729 3 be be VB cord-302530-pp6bl941 729 4 remembered remember VBN cord-302530-pp6bl941 729 5 that that IN cord-302530-pp6bl941 729 6 HIV HIV NNP cord-302530-pp6bl941 729 7 only only RB cord-302530-pp6bl941 729 8 infects infect VBZ cord-302530-pp6bl941 729 9 humans human NNS cord-302530-pp6bl941 729 10 at at IN cord-302530-pp6bl941 729 11 37 37 CD cord-302530-pp6bl941 729 12 ° ° NN cord-302530-pp6bl941 729 13 C c NN cord-302530-pp6bl941 729 14 and and CC cord-302530-pp6bl941 729 15 therefore therefore RB cord-302530-pp6bl941 729 16 the the DT cord-302530-pp6bl941 729 17 lower low JJR cord-302530-pp6bl941 729 18 temperature temperature NN cord-302530-pp6bl941 729 19 predictions prediction NNS cord-302530-pp6bl941 729 20 are be VBP cord-302530-pp6bl941 729 21 more more JJR cord-302530-pp6bl941 729 22 of of IN cord-302530-pp6bl941 729 23 academic academic JJ cord-302530-pp6bl941 729 24 interest interest NN cord-302530-pp6bl941 729 25 , , , cord-302530-pp6bl941 729 26 although although IN cord-302530-pp6bl941 729 27 temperature temperature NN cord-302530-pp6bl941 729 28 trends trend NNS cord-302530-pp6bl941 729 29 may may MD cord-302530-pp6bl941 729 30 give give VB cord-302530-pp6bl941 729 31 an an DT cord-302530-pp6bl941 729 32 insight insight NN cord-302530-pp6bl941 729 33 into into IN cord-302530-pp6bl941 729 34 weaknesses weakness NNS cord-302530-pp6bl941 729 35 in in IN cord-302530-pp6bl941 729 36 the the DT cord-302530-pp6bl941 729 37 HIV HIV NNP cord-302530-pp6bl941 729 38 infection infection NN cord-302530-pp6bl941 729 39 strategy strategy NN cord-302530-pp6bl941 729 40 as as IN cord-302530-pp6bl941 729 41 suggested suggest VBN cord-302530-pp6bl941 729 42 here here RB cord-302530-pp6bl941 729 43 . . . cord-302530-pp6bl941 730 1 It -PRON- PRP cord-302530-pp6bl941 730 2 is be VBZ cord-302530-pp6bl941 730 3 only only RB cord-302530-pp6bl941 730 4 the the DT cord-302530-pp6bl941 730 5 37 37 CD cord-302530-pp6bl941 730 6 ° ° NN cord-302530-pp6bl941 730 7 C c NN cord-302530-pp6bl941 730 8 line line NN cord-302530-pp6bl941 730 9 in in IN cord-302530-pp6bl941 730 10 Fig Fig NNP cord-302530-pp6bl941 730 11 . . . cord-302530-pp6bl941 730 12 5c 5c NNP cord-302530-pp6bl941 730 13 which which WDT cord-302530-pp6bl941 730 14 is be VBZ cord-302530-pp6bl941 730 15 important important JJ cord-302530-pp6bl941 730 16 for for IN cord-302530-pp6bl941 730 17 HIV HIV NNP cord-302530-pp6bl941 731 1 and and CC cord-302530-pp6bl941 731 2 it -PRON- PRP cord-302530-pp6bl941 731 3 is be VBZ cord-302530-pp6bl941 731 4 reassuring reassure VBG cord-302530-pp6bl941 731 5 to to TO cord-302530-pp6bl941 731 6 note note VB cord-302530-pp6bl941 731 7 that that IN cord-302530-pp6bl941 731 8 this this DT cord-302530-pp6bl941 731 9 is be VBZ cord-302530-pp6bl941 731 10 based base VBN cord-302530-pp6bl941 731 11 on on IN cord-302530-pp6bl941 731 12 actual actual JJ cord-302530-pp6bl941 731 13 experimental experimental JJ cord-302530-pp6bl941 731 14 data datum NNS cord-302530-pp6bl941 731 15 for for IN cord-302530-pp6bl941 731 16 gp120 gp120 NNP cord-302530-pp6bl941 731 17 monomer monomer NN cord-302530-pp6bl941 731 18 : : : cord-302530-pp6bl941 732 1 CD4 CD4 NNP cord-302530-pp6bl941 732 2 binding bind VBG cord-302530-pp6bl941 732 3 measured measure VBN cord-302530-pp6bl941 732 4 at at IN cord-302530-pp6bl941 732 5 that that DT cord-302530-pp6bl941 732 6 temperature temperature NN cord-302530-pp6bl941 732 7 . . . cord-302530-pp6bl941 733 1 The the DT cord-302530-pp6bl941 733 2 lower low JJR cord-302530-pp6bl941 733 3 temperature temperature NN cord-302530-pp6bl941 733 4 lines line NNS cord-302530-pp6bl941 733 5 in in IN cord-302530-pp6bl941 733 6 Fig Fig NNP cord-302530-pp6bl941 733 7 . . . cord-302530-pp6bl941 734 1 5c 5c NNP cord-302530-pp6bl941 734 2 are be VBP cord-302530-pp6bl941 734 3 of of IN cord-302530-pp6bl941 734 4 more more JJR cord-302530-pp6bl941 734 5 general general JJ cord-302530-pp6bl941 734 6 interest interest NN cord-302530-pp6bl941 734 7 , , , cord-302530-pp6bl941 734 8 for for IN cord-302530-pp6bl941 734 9 example example NN cord-302530-pp6bl941 734 10 in in IN cord-302530-pp6bl941 734 11 explaining explain VBG cord-302530-pp6bl941 734 12 the the DT cord-302530-pp6bl941 734 13 observed observed JJ cord-302530-pp6bl941 734 14 relationship relationship NN cord-302530-pp6bl941 734 15 ( ( -LRB- cord-302530-pp6bl941 734 16 Nifong Nifong NNP cord-302530-pp6bl941 734 17 and and CC cord-302530-pp6bl941 734 18 Gillooly Gillooly NNP cord-302530-pp6bl941 734 19 2016 2016 CD cord-302530-pp6bl941 734 20 ) ) -RRB- cord-302530-pp6bl941 734 21 between between IN cord-302530-pp6bl941 734 22 larger large JJR cord-302530-pp6bl941 734 23 virus virus NN cord-302530-pp6bl941 734 24 volume volume NN cord-302530-pp6bl941 734 25 and and CC cord-302530-pp6bl941 734 26 lower low JJR cord-302530-pp6bl941 734 27 host host NN cord-302530-pp6bl941 734 28 temperature temperature NN cord-302530-pp6bl941 734 29 . . . cord-302530-pp6bl941 735 1 Individual individual JJ cord-302530-pp6bl941 735 2 virions virion NNS cord-302530-pp6bl941 735 3 of of IN cord-302530-pp6bl941 735 4 the the DT cord-302530-pp6bl941 735 5 same same JJ cord-302530-pp6bl941 735 6 virus virus NN cord-302530-pp6bl941 735 7 may may MD cord-302530-pp6bl941 735 8 vary vary VB cord-302530-pp6bl941 735 9 both both DT cord-302530-pp6bl941 735 10 in in IN cord-302530-pp6bl941 735 11 size size NN cord-302530-pp6bl941 735 12 ( ( -LRB- cord-302530-pp6bl941 735 13 Briggs Briggs NNP cord-302530-pp6bl941 735 14 et et NNP cord-302530-pp6bl941 735 15 al al NNP cord-302530-pp6bl941 735 16 . . NNP cord-302530-pp6bl941 735 17 , , , cord-302530-pp6bl941 735 18 2003 2003 CD cord-302530-pp6bl941 735 19 ) ) -RRB- cord-302530-pp6bl941 735 20 and and CC cord-302530-pp6bl941 735 21 in in IN cord-302530-pp6bl941 735 22 the the DT cord-302530-pp6bl941 735 23 case case NN cord-302530-pp6bl941 735 24 of of IN cord-302530-pp6bl941 735 25 some some DT cord-302530-pp6bl941 735 26 RNA RNA NNP cord-302530-pp6bl941 735 27 viruses virus NNS cord-302530-pp6bl941 735 28 in in IN cord-302530-pp6bl941 735 29 the the DT cord-302530-pp6bl941 735 30 actual actual JJ cord-302530-pp6bl941 735 31 base base NN cord-302530-pp6bl941 735 32 sequence sequence NN cord-302530-pp6bl941 735 33 of of IN cord-302530-pp6bl941 735 34 the the DT cord-302530-pp6bl941 735 35 genome genome NN cord-302530-pp6bl941 735 36 giving give VBG cord-302530-pp6bl941 735 37 a a DT cord-302530-pp6bl941 735 38 spectrum spectrum NN cord-302530-pp6bl941 735 39 of of IN cord-302530-pp6bl941 735 40 mutants mutant NNS cord-302530-pp6bl941 735 41 . . . cord-302530-pp6bl941 736 1 The the DT cord-302530-pp6bl941 736 2 infection infection NN cord-302530-pp6bl941 736 3 process process NN cord-302530-pp6bl941 736 4 may may MD cord-302530-pp6bl941 736 5 represent represent VB cord-302530-pp6bl941 736 6 a a DT cord-302530-pp6bl941 736 7 bottleneck bottleneck NN cord-302530-pp6bl941 736 8 such such JJ cord-302530-pp6bl941 736 9 that that IN cord-302530-pp6bl941 736 10 only only RB cord-302530-pp6bl941 736 11 one one CD cord-302530-pp6bl941 736 12 or or CC cord-302530-pp6bl941 736 13 two two CD cord-302530-pp6bl941 736 14 viral viral JJ cord-302530-pp6bl941 736 15 variants variant NNS cord-302530-pp6bl941 736 16 in in IN cord-302530-pp6bl941 736 17 the the DT cord-302530-pp6bl941 736 18 exposure exposure NN cord-302530-pp6bl941 736 19 dose dose NN cord-302530-pp6bl941 736 20 successfully successfully RB cord-302530-pp6bl941 736 21 establish establish VB cord-302530-pp6bl941 736 22 infection infection NN cord-302530-pp6bl941 737 1 ( ( -LRB- cord-302530-pp6bl941 737 2 Bull Bull NNP cord-302530-pp6bl941 737 3 et et NNP cord-302530-pp6bl941 737 4 al al NNP cord-302530-pp6bl941 737 5 . . NNP cord-302530-pp6bl941 737 6 , , , cord-302530-pp6bl941 737 7 2011 2011 CD cord-302530-pp6bl941 737 8 ) ) -RRB- cord-302530-pp6bl941 737 9 . . . cord-302530-pp6bl941 738 1 Thus thus RB cord-302530-pp6bl941 738 2 in in IN cord-302530-pp6bl941 738 3 the the DT cord-302530-pp6bl941 738 4 case case NN cord-302530-pp6bl941 738 5 of of IN cord-302530-pp6bl941 738 6 norovirus norovirus NN cord-302530-pp6bl941 738 7 , , , cord-302530-pp6bl941 738 8 only only RB cord-302530-pp6bl941 738 9 minor minor JJ cord-302530-pp6bl941 738 10 variants variant NNS cord-302530-pp6bl941 738 11 at at IN cord-302530-pp6bl941 738 12 frequencies frequency NNS cord-302530-pp6bl941 738 13 as as RB cord-302530-pp6bl941 738 14 low low JJ cord-302530-pp6bl941 738 15 as as IN cord-302530-pp6bl941 738 16 0.01 0.01 CD cord-302530-pp6bl941 738 17 % % NN cord-302530-pp6bl941 738 18 were be VBD cord-302530-pp6bl941 738 19 successfully successfully RB cord-302530-pp6bl941 738 20 transmitted transmit VBN cord-302530-pp6bl941 738 21 to to TO cord-302530-pp6bl941 738 22 establish establish VB cord-302530-pp6bl941 738 23 a a DT cord-302530-pp6bl941 738 24 new new JJ cord-302530-pp6bl941 738 25 infection infection NN cord-302530-pp6bl941 738 26 ( ( -LRB- cord-302530-pp6bl941 738 27 Bull Bull NNP cord-302530-pp6bl941 738 28 et et NNP cord-302530-pp6bl941 738 29 al al NNP cord-302530-pp6bl941 738 30 . . NNP cord-302530-pp6bl941 738 31 , , , cord-302530-pp6bl941 738 32 2012 2012 CD cord-302530-pp6bl941 738 33 ) ) -RRB- cord-302530-pp6bl941 738 34 . . . cord-302530-pp6bl941 739 1 The the DT cord-302530-pp6bl941 739 2 work work NN cord-302530-pp6bl941 739 3 here here RB cord-302530-pp6bl941 739 4 suggests suggest VBZ cord-302530-pp6bl941 739 5 that that IN cord-302530-pp6bl941 739 6 the the DT cord-302530-pp6bl941 739 7 actual actual JJ cord-302530-pp6bl941 739 8 size size NN cord-302530-pp6bl941 739 9 of of IN cord-302530-pp6bl941 739 10 the the DT cord-302530-pp6bl941 739 11 virion virion NN cord-302530-pp6bl941 739 12 itself -PRON- PRP cord-302530-pp6bl941 739 13 may may MD cord-302530-pp6bl941 739 14 present present VB cord-302530-pp6bl941 739 15 an an DT cord-302530-pp6bl941 739 16 additional additional JJ cord-302530-pp6bl941 739 17 constraint constraint NN cord-302530-pp6bl941 739 18 particularly particularly RB cord-302530-pp6bl941 739 19 at at IN cord-302530-pp6bl941 739 20 mammalian mammalian JJ cord-302530-pp6bl941 739 21 body body NN cord-302530-pp6bl941 739 22 temperatures temperature NNS cord-302530-pp6bl941 739 23 . . . cord-302530-pp6bl941 740 1 Thus thus RB cord-302530-pp6bl941 740 2 although although IN cord-302530-pp6bl941 740 3 the the DT cord-302530-pp6bl941 740 4 average average JJ cord-302530-pp6bl941 740 5 diameter diameter NN cord-302530-pp6bl941 740 6 for for IN cord-302530-pp6bl941 740 7 HIV HIV NNP cord-302530-pp6bl941 740 8 virions virion NNS cord-302530-pp6bl941 740 9 with with IN cord-302530-pp6bl941 740 10 a a DT cord-302530-pp6bl941 740 11 single single JJ cord-302530-pp6bl941 740 12 core core NN cord-302530-pp6bl941 740 13 is be VBZ cord-302530-pp6bl941 740 14 134 134 CD cord-302530-pp6bl941 740 15 nm nm NN cord-302530-pp6bl941 740 16 , , , cord-302530-pp6bl941 740 17 individual individual JJ cord-302530-pp6bl941 740 18 virions virion NNS cord-302530-pp6bl941 740 19 display display VBP cord-302530-pp6bl941 740 20 a a DT cord-302530-pp6bl941 740 21 broad broad JJ cord-302530-pp6bl941 740 22 range range NN cord-302530-pp6bl941 740 23 of of IN cord-302530-pp6bl941 740 24 diameters diameter NNS cord-302530-pp6bl941 740 25 extending extend VBG cord-302530-pp6bl941 740 26 from from IN cord-302530-pp6bl941 740 27 120 120 CD cord-302530-pp6bl941 740 28 to to IN cord-302530-pp6bl941 740 29 200 200 CD cord-302530-pp6bl941 740 30 nm nm NN cord-302530-pp6bl941 740 31 with with IN cord-302530-pp6bl941 740 32 a a DT cord-302530-pp6bl941 740 33 skewed skewed JJ cord-302530-pp6bl941 740 34 distribution distribution NN cord-302530-pp6bl941 740 35 ( ( -LRB- cord-302530-pp6bl941 740 36 Briggs Briggs NNP cord-302530-pp6bl941 740 37 et et NNP cord-302530-pp6bl941 740 38 al al NNP cord-302530-pp6bl941 740 39 . . NNP cord-302530-pp6bl941 740 40 , , , cord-302530-pp6bl941 740 41 2003 2003 CD cord-302530-pp6bl941 740 42 ) ) -RRB- cord-302530-pp6bl941 740 43 . . . cord-302530-pp6bl941 741 1 Furthermore furthermore RB cord-302530-pp6bl941 741 2 while while IN cord-302530-pp6bl941 741 3 the the DT cord-302530-pp6bl941 741 4 majority majority NN cord-302530-pp6bl941 741 5 of of IN cord-302530-pp6bl941 741 6 HIV HIV NNP cord-302530-pp6bl941 741 7 virions virion NNS cord-302530-pp6bl941 741 8 contained contain VBD cord-302530-pp6bl941 741 9 a a DT cord-302530-pp6bl941 741 10 single single JJ cord-302530-pp6bl941 741 11 core core NN cord-302530-pp6bl941 741 12 , , , cord-302530-pp6bl941 741 13 almost almost RB cord-302530-pp6bl941 741 14 a a DT cord-302530-pp6bl941 741 15 third third NN cord-302530-pp6bl941 741 16 contained contain VBN cord-302530-pp6bl941 741 17 two two CD cord-302530-pp6bl941 741 18 or or CC cord-302530-pp6bl941 741 19 more more JJR cord-302530-pp6bl941 741 20 cores core NNS cord-302530-pp6bl941 741 21 . . . cord-302530-pp6bl941 742 1 The the DT cord-302530-pp6bl941 742 2 mean mean JJ cord-302530-pp6bl941 742 3 diameter diameter NN cord-302530-pp6bl941 742 4 of of IN cord-302530-pp6bl941 742 5 the the DT cord-302530-pp6bl941 742 6 HIV HIV NNP cord-302530-pp6bl941 742 7 virions virion NNS cord-302530-pp6bl941 742 8 containing contain VBG cord-302530-pp6bl941 742 9 a a DT cord-302530-pp6bl941 742 10 single single JJ cord-302530-pp6bl941 742 11 core core NN cord-302530-pp6bl941 742 12 ( ( -LRB- cord-302530-pp6bl941 742 13 134 134 CD cord-302530-pp6bl941 742 14 ± ± CD cord-302530-pp6bl941 742 15 11 11 CD cord-302530-pp6bl941 742 16 nm nm NN cord-302530-pp6bl941 742 17 , , , cord-302530-pp6bl941 742 18 n n NN cord-302530-pp6bl941 742 19 = = SYM cord-302530-pp6bl941 742 20 89 89 CD cord-302530-pp6bl941 742 21 ) ) -RRB- cord-302530-pp6bl941 742 22 was be VBD cord-302530-pp6bl941 742 23 significantly significantly RB cord-302530-pp6bl941 742 24 smaller small JJR cord-302530-pp6bl941 742 25 than than IN cord-302530-pp6bl941 742 26 the the DT cord-302530-pp6bl941 742 27 mean mean JJ cord-302530-pp6bl941 742 28 diameter diameter NN cord-302530-pp6bl941 742 29 of of IN cord-302530-pp6bl941 742 30 virions virion NNS cord-302530-pp6bl941 742 31 containing contain VBG cord-302530-pp6bl941 742 32 two two CD cord-302530-pp6bl941 742 33 cores core NNS cord-302530-pp6bl941 742 34 ( ( -LRB- cord-302530-pp6bl941 742 35 158 158 CD cord-302530-pp6bl941 742 36 ± ± NNP cord-302530-pp6bl941 742 37 16 16 CD cord-302530-pp6bl941 742 38 nm nm NN cord-302530-pp6bl941 742 39 , , , cord-302530-pp6bl941 742 40 n n NN cord-302530-pp6bl941 742 41 = = SYM cord-302530-pp6bl941 742 42 43 43 CD cord-302530-pp6bl941 742 43 ) ) -RRB- cord-302530-pp6bl941 743 1 ( ( -LRB- cord-302530-pp6bl941 743 2 Briggs Briggs NNP cord-302530-pp6bl941 743 3 et et NNP cord-302530-pp6bl941 743 4 al al NNP cord-302530-pp6bl941 743 5 . . NNP cord-302530-pp6bl941 743 6 , , , cord-302530-pp6bl941 743 7 2003 2003 CD cord-302530-pp6bl941 743 8 ) ) -RRB- cord-302530-pp6bl941 743 9 . . . cord-302530-pp6bl941 744 1 Thus thus RB cord-302530-pp6bl941 744 2 the the DT cord-302530-pp6bl941 744 3 magnitude magnitude NN cord-302530-pp6bl941 744 4 of of IN cord-302530-pp6bl941 744 5 ΔS ΔS NNP cord-302530-pp6bl941 744 6 a_immob a_immob NNP cord-302530-pp6bl941 744 7 may may MD cord-302530-pp6bl941 744 8 vary vary VB cord-302530-pp6bl941 744 9 between between IN cord-302530-pp6bl941 744 10 individual individual JJ cord-302530-pp6bl941 744 11 HIV HIV NNP cord-302530-pp6bl941 744 12 virions virion NNS cord-302530-pp6bl941 744 13 within within IN cord-302530-pp6bl941 744 14 the the DT cord-302530-pp6bl941 744 15 same same JJ cord-302530-pp6bl941 744 16 exposure exposure NN cord-302530-pp6bl941 744 17 dose dose NN cord-302530-pp6bl941 744 18 . . . cord-302530-pp6bl941 745 1 The the DT cord-302530-pp6bl941 745 2 key key JJ cord-302530-pp6bl941 745 3 conclusion conclusion NN cord-302530-pp6bl941 745 4 from from IN cord-302530-pp6bl941 745 5 Fig Fig NNP cord-302530-pp6bl941 745 6 . . . cord-302530-pp6bl941 746 1 5c 5c NNP cord-302530-pp6bl941 746 2 is be VBZ cord-302530-pp6bl941 746 3 that that IN cord-302530-pp6bl941 746 4 the the DT cord-302530-pp6bl941 746 5 number number NN cord-302530-pp6bl941 746 6 of of IN cord-302530-pp6bl941 746 7 CD4 CD4 NNP cord-302530-pp6bl941 746 8 + + CC cord-302530-pp6bl941 746 9 T t NN cord-302530-pp6bl941 746 10 cells cell NNS cord-302530-pp6bl941 746 11 with with IN cord-302530-pp6bl941 746 12 bound bind VBN cord-302530-pp6bl941 746 13 virus virus NN cord-302530-pp6bl941 746 14 is be VBZ cord-302530-pp6bl941 746 15 highly highly RB cord-302530-pp6bl941 746 16 sensitive sensitive JJ cord-302530-pp6bl941 746 17 to to IN cord-302530-pp6bl941 746 18 the the DT cord-302530-pp6bl941 746 19 magnitude magnitude NN cord-302530-pp6bl941 746 20 of of IN cord-302530-pp6bl941 746 21 ΔS ΔS NNP cord-302530-pp6bl941 746 22 a_immob a_immob NNP cord-302530-pp6bl941 746 23 with with IN cord-302530-pp6bl941 746 24 just just RB cord-302530-pp6bl941 746 25 a a DT cord-302530-pp6bl941 746 26 4.5 4.5 CD cord-302530-pp6bl941 746 27 % % NN cord-302530-pp6bl941 746 28 increase increase NN cord-302530-pp6bl941 746 29 in in IN cord-302530-pp6bl941 746 30 the the DT cord-302530-pp6bl941 746 31 magnitude magnitude NN cord-302530-pp6bl941 746 32 of of IN cord-302530-pp6bl941 746 33 ΔS ΔS NNP cord-302530-pp6bl941 746 34 a_immob a_immob NNP cord-302530-pp6bl941 746 35 from from IN cord-302530-pp6bl941 746 36 -290 -290 NN cord-302530-pp6bl941 746 37 to to IN cord-302530-pp6bl941 746 38 -277 -277 XX cord-302530-pp6bl941 747 1 J J NNP cord-302530-pp6bl941 747 2 / / SYM cord-302530-pp6bl941 747 3 mol mol NNP cord-302530-pp6bl941 747 4 / / SYM cord-302530-pp6bl941 747 5 K K NNP cord-302530-pp6bl941 747 6 for for IN cord-302530-pp6bl941 747 7 example example NN cord-302530-pp6bl941 747 8 increasing increase VBG cord-302530-pp6bl941 747 9 C.V C.V NNP cord-302530-pp6bl941 747 10 T T NNP cord-302530-pp6bl941 747 11 by by IN cord-302530-pp6bl941 747 12 five five CD cord-302530-pp6bl941 747 13 - - RB cord-302530-pp6bl941 747 14 fold fold RB cord-302530-pp6bl941 747 15 from from IN cord-302530-pp6bl941 747 16 1 1 CD cord-302530-pp6bl941 747 17 to to IN cord-302530-pp6bl941 747 18 5 5 CD cord-302530-pp6bl941 747 19 CD4 CD4 NNP cord-302530-pp6bl941 747 20 + + CC cord-302530-pp6bl941 747 21 T t NN cord-302530-pp6bl941 747 22 cells cell NNS cord-302530-pp6bl941 747 23 per per IN cord-302530-pp6bl941 747 24 mm mm NN cord-302530-pp6bl941 747 25 3 3 CD cord-302530-pp6bl941 747 26 of of IN cord-302530-pp6bl941 747 27 blood blood NN cord-302530-pp6bl941 747 28 at at IN cord-302530-pp6bl941 747 29 37 37 CD cord-302530-pp6bl941 747 30 ° ° NN cord-302530-pp6bl941 747 31 C c NN cord-302530-pp6bl941 747 32 . . . cord-302530-pp6bl941 748 1 Thus thus RB cord-302530-pp6bl941 748 2 smaller small JJR cord-302530-pp6bl941 748 3 diameter diameter NN cord-302530-pp6bl941 748 4 viruses virus NNS cord-302530-pp6bl941 748 5 in in IN cord-302530-pp6bl941 748 6 a a DT cord-302530-pp6bl941 748 7 challenge challenge NN cord-302530-pp6bl941 748 8 does do VBZ cord-302530-pp6bl941 748 9 may may MD cord-302530-pp6bl941 748 10 have have VB cord-302530-pp6bl941 748 11 an an DT cord-302530-pp6bl941 748 12 advantage advantage NN cord-302530-pp6bl941 748 13 in in IN cord-302530-pp6bl941 748 14 binding bind VBG cord-302530-pp6bl941 748 15 and and CC cord-302530-pp6bl941 748 16 hence hence RB cord-302530-pp6bl941 748 17 initiating initiate VBG cord-302530-pp6bl941 748 18 infection infection NN cord-302530-pp6bl941 748 19 at at IN cord-302530-pp6bl941 748 20 mammalian mammalian JJ cord-302530-pp6bl941 748 21 body body NN cord-302530-pp6bl941 748 22 temperatures temperature NNS cord-302530-pp6bl941 748 23 . . . cord-302530-pp6bl941 749 1 This this DT cord-302530-pp6bl941 749 2 also also RB cord-302530-pp6bl941 749 3 raises raise VBZ cord-302530-pp6bl941 749 4 the the DT cord-302530-pp6bl941 749 5 question question NN cord-302530-pp6bl941 749 6 of of IN cord-302530-pp6bl941 749 7 the the DT cord-302530-pp6bl941 749 8 magnitude magnitude NN cord-302530-pp6bl941 749 9 of of IN cord-302530-pp6bl941 749 10 ΔS ΔS NNP cord-302530-pp6bl941 749 11 a_immob a_immob NNP cord-302530-pp6bl941 749 12 for for IN cord-302530-pp6bl941 749 13 an an DT cord-302530-pp6bl941 749 14 aggregate aggregate NN cord-302530-pp6bl941 749 15 containing contain VBG cord-302530-pp6bl941 749 16 several several JJ cord-302530-pp6bl941 749 17 virions virion NNS cord-302530-pp6bl941 749 18 of of IN cord-302530-pp6bl941 749 19 the the DT cord-302530-pp6bl941 749 20 same same JJ cord-302530-pp6bl941 749 21 virus virus NN cord-302530-pp6bl941 749 22 and and CC cord-302530-pp6bl941 749 23 in in IN cord-302530-pp6bl941 749 24 the the DT cord-302530-pp6bl941 749 25 case case NN cord-302530-pp6bl941 749 26 of of IN cord-302530-pp6bl941 749 27 EBOV EBOV NNP cord-302530-pp6bl941 749 28 , , , cord-302530-pp6bl941 749 29 for for IN cord-302530-pp6bl941 749 30 the the DT cord-302530-pp6bl941 749 31 long long JJ cord-302530-pp6bl941 749 32 filaments filament NNS cord-302530-pp6bl941 749 33 linking link VBG cord-302530-pp6bl941 749 34 multiple multiple JJ cord-302530-pp6bl941 749 35 genome genome NN cord-302530-pp6bl941 749 36 copies copy NNS cord-302530-pp6bl941 749 37 ( ( -LRB- cord-302530-pp6bl941 749 38 Beniac Beniac NNP cord-302530-pp6bl941 749 39 et et NNP cord-302530-pp6bl941 749 40 al al NNP cord-302530-pp6bl941 749 41 . . NNP cord-302530-pp6bl941 749 42 , , , cord-302530-pp6bl941 749 43 2012 2012 CD cord-302530-pp6bl941 749 44 ) ) -RRB- cord-302530-pp6bl941 749 45 . . . cord-302530-pp6bl941 750 1 It -PRON- PRP cord-302530-pp6bl941 750 2 has have VBZ cord-302530-pp6bl941 750 3 previously previously RB cord-302530-pp6bl941 750 4 been be VBN cord-302530-pp6bl941 750 5 proposed propose VBN cord-302530-pp6bl941 750 6 that that IN cord-302530-pp6bl941 750 7 fusing fuse VBG cord-302530-pp6bl941 750 8 multiple multiple JJ cord-302530-pp6bl941 750 9 genome genome NN cord-302530-pp6bl941 750 10 copies copy NNS cord-302530-pp6bl941 750 11 into into IN cord-302530-pp6bl941 750 12 the the DT cord-302530-pp6bl941 750 13 same same JJ cord-302530-pp6bl941 750 14 filament filament NN cord-302530-pp6bl941 750 15 in in IN cord-302530-pp6bl941 750 16 the the DT cord-302530-pp6bl941 750 17 case case NN cord-302530-pp6bl941 750 18 of of IN cord-302530-pp6bl941 750 19 EBOV EBOV NNP cord-302530-pp6bl941 750 20 takes take VBZ cord-302530-pp6bl941 750 21 some some DT cord-302530-pp6bl941 750 22 of of IN cord-302530-pp6bl941 750 23 the the DT cord-302530-pp6bl941 750 24 entropy entropy NN cord-302530-pp6bl941 750 25 loss loss NN cord-302530-pp6bl941 750 26 for for IN cord-302530-pp6bl941 750 27 ΔS ΔS NNP cord-302530-pp6bl941 750 28 a_immob a_immob NNP cord-302530-pp6bl941 750 29 prior prior RB cord-302530-pp6bl941 750 30 to to IN cord-302530-pp6bl941 750 31 binding bind VBG cord-302530-pp6bl941 750 32 to to IN cord-302530-pp6bl941 750 33 the the DT cord-302530-pp6bl941 750 34 cell cell NN cord-302530-pp6bl941 750 35 surface surface NN cord-302530-pp6bl941 750 36 ( ( -LRB- cord-302530-pp6bl941 750 37 Gale Gale NNP cord-302530-pp6bl941 750 38 2017 2017 CD cord-302530-pp6bl941 750 39 ) ) -RRB- cord-302530-pp6bl941 751 1 such such JJ cord-302530-pp6bl941 751 2 that that DT cord-302530-pp6bl941 751 3 aggregation aggregation NN cord-302530-pp6bl941 751 4 can can MD cord-302530-pp6bl941 751 5 be be VB cord-302530-pp6bl941 751 6 viewed view VBN cord-302530-pp6bl941 751 7 as as IN cord-302530-pp6bl941 751 8 a a DT cord-302530-pp6bl941 751 9 cooperative cooperative JJ cord-302530-pp6bl941 751 10 effect effect NN cord-302530-pp6bl941 751 11 in in IN cord-302530-pp6bl941 751 12 the the DT cord-302530-pp6bl941 751 13 infection infection NN cord-302530-pp6bl941 751 14 process process NN cord-302530-pp6bl941 751 15 . . . cord-302530-pp6bl941 752 1 The the DT cord-302530-pp6bl941 752 2 effect effect NN cord-302530-pp6bl941 752 3 of of IN cord-302530-pp6bl941 752 4 aggregation aggregation NN cord-302530-pp6bl941 752 5 and and CC cord-302530-pp6bl941 752 6 virus virus NN cord-302530-pp6bl941 752 7 size size NN cord-302530-pp6bl941 752 8 on on IN cord-302530-pp6bl941 752 9 the the DT cord-302530-pp6bl941 752 10 magnitude magnitude NN cord-302530-pp6bl941 752 11 of of IN cord-302530-pp6bl941 752 12 ΔS ΔS NNP cord-302530-pp6bl941 752 13 a_immob a_immob NNP cord-302530-pp6bl941 752 14 according accord VBG cord-302530-pp6bl941 752 15 to to IN cord-302530-pp6bl941 752 16 Eq Eq NNP cord-302530-pp6bl941 752 17 . . . cord-302530-pp6bl941 753 1 ( ( -LRB- cord-302530-pp6bl941 753 2 18 18 CD cord-302530-pp6bl941 753 3 ) ) -RRB- cord-302530-pp6bl941 753 4 needs need VBZ cord-302530-pp6bl941 753 5 to to TO cord-302530-pp6bl941 753 6 be be VB cord-302530-pp6bl941 753 7 investigated investigate VBN cord-302530-pp6bl941 753 8 and and CC cord-302530-pp6bl941 753 9 understood understand VBN cord-302530-pp6bl941 753 10 to to TO cord-302530-pp6bl941 753 11 further further RB cord-302530-pp6bl941 753 12 the the DT cord-302530-pp6bl941 753 13 work work NN cord-302530-pp6bl941 753 14 here here RB cord-302530-pp6bl941 753 15 . . . cord-302530-pp6bl941 754 1 From from IN cord-302530-pp6bl941 754 2 a a DT cord-302530-pp6bl941 754 3 thermodynamic thermodynamic JJ cord-302530-pp6bl941 754 4 perspective perspective NN cord-302530-pp6bl941 754 5 , , , cord-302530-pp6bl941 754 6 the the DT cord-302530-pp6bl941 754 7 affinity affinity NN cord-302530-pp6bl941 754 8 of of IN cord-302530-pp6bl941 754 9 virus virus NN cord-302530-pp6bl941 754 10 binding bind VBG cord-302530-pp6bl941 754 11 to to IN cord-302530-pp6bl941 754 12 a a DT cord-302530-pp6bl941 754 13 host host NN cord-302530-pp6bl941 754 14 cell cell NN cord-302530-pp6bl941 754 15 is be VBZ cord-302530-pp6bl941 754 16 greatly greatly RB cord-302530-pp6bl941 754 17 decreased decrease VBN cord-302530-pp6bl941 754 18 at at IN cord-302530-pp6bl941 754 19 the the DT cord-302530-pp6bl941 754 20 higher high JJR cord-302530-pp6bl941 754 21 body body NN cord-302530-pp6bl941 754 22 temperatures temperature NNS cord-302530-pp6bl941 754 23 of of IN cord-302530-pp6bl941 754 24 mammals mammal NNS cord-302530-pp6bl941 754 25 and and CC cord-302530-pp6bl941 754 26 birds bird NNS cord-302530-pp6bl941 754 27 such such JJ cord-302530-pp6bl941 754 28 that that IN cord-302530-pp6bl941 754 29 temperature temperature NN cord-302530-pp6bl941 754 30 can can MD cord-302530-pp6bl941 754 31 be be VB cord-302530-pp6bl941 754 32 considered consider VBN cord-302530-pp6bl941 754 33 a a DT cord-302530-pp6bl941 754 34 constraint constraint NN cord-302530-pp6bl941 754 35 to to TO cord-302530-pp6bl941 754 36 be be VB cord-302530-pp6bl941 754 37 overcome overcome VBN cord-302530-pp6bl941 754 38 . . . cord-302530-pp6bl941 755 1 The the DT cord-302530-pp6bl941 755 2 relationship relationship NN cord-302530-pp6bl941 755 3 between between IN cord-302530-pp6bl941 755 4 binding bind VBG cord-302530-pp6bl941 755 5 affinity affinity NN cord-302530-pp6bl941 755 6 and and CC cord-302530-pp6bl941 755 7 temperature temperature NN cord-302530-pp6bl941 755 8 can can MD cord-302530-pp6bl941 755 9 be be VB cord-302530-pp6bl941 755 10 markedly markedly RB cord-302530-pp6bl941 755 11 affected affect VBN cord-302530-pp6bl941 755 12 by by IN cord-302530-pp6bl941 755 13 the the DT cord-302530-pp6bl941 755 14 change change NN cord-302530-pp6bl941 755 15 in in IN cord-302530-pp6bl941 755 16 heat heat NN cord-302530-pp6bl941 755 17 capacity capacity NN cord-302530-pp6bl941 755 18 ( ( -LRB- cord-302530-pp6bl941 755 19 ΔC ΔC NNP cord-302530-pp6bl941 755 20 p p NN cord-302530-pp6bl941 755 21 ) ) -RRB- cord-302530-pp6bl941 755 22 on on IN cord-302530-pp6bl941 755 23 virus virus NN cord-302530-pp6bl941 755 24 binding bind VBG cord-302530-pp6bl941 755 25 through through IN cord-302530-pp6bl941 755 26 its -PRON- PRP$ cord-302530-pp6bl941 755 27 effect effect NN cord-302530-pp6bl941 755 28 on on IN cord-302530-pp6bl941 755 29 the the DT cord-302530-pp6bl941 755 30 enthalpy enthalpy NN cord-302530-pp6bl941 755 31 and and CC cord-302530-pp6bl941 755 32 entropy entropy NN cord-302530-pp6bl941 755 33 of of IN cord-302530-pp6bl941 755 34 the the DT cord-302530-pp6bl941 755 35 GP GP NNP cord-302530-pp6bl941 755 36 / / SYM cord-302530-pp6bl941 755 37 Cr cr NN cord-302530-pp6bl941 755 38 interaction interaction NN cord-302530-pp6bl941 755 39 . . . cord-302530-pp6bl941 756 1 Specifically specifically RB cord-302530-pp6bl941 756 2 large large JJ cord-302530-pp6bl941 756 3 negative negative JJ cord-302530-pp6bl941 756 4 values value NNS cord-302530-pp6bl941 756 5 of of IN cord-302530-pp6bl941 756 6 ΔC δc NN cord-302530-pp6bl941 756 7 p p NN cord-302530-pp6bl941 756 8 reduce reduce NN cord-302530-pp6bl941 756 9 binding binding NN cord-302530-pp6bl941 756 10 at at IN cord-302530-pp6bl941 756 11 both both CC cord-302530-pp6bl941 756 12 low low JJ cord-302530-pp6bl941 756 13 and and CC cord-302530-pp6bl941 756 14 high high JJ cord-302530-pp6bl941 756 15 temperatures temperature NNS cord-302530-pp6bl941 756 16 giving give VBG cord-302530-pp6bl941 756 17 a a DT cord-302530-pp6bl941 756 18 peak peak NN cord-302530-pp6bl941 756 19 binding binding NN cord-302530-pp6bl941 756 20 at at IN cord-302530-pp6bl941 756 21 a a DT cord-302530-pp6bl941 756 22 medium medium JJ cord-302530-pp6bl941 756 23 temperature temperature NN cord-302530-pp6bl941 756 24 as as IN cord-302530-pp6bl941 756 25 has have VBZ cord-302530-pp6bl941 756 26 been be VBN cord-302530-pp6bl941 756 27 observed observe VBN cord-302530-pp6bl941 756 28 experimentally experimentally RB cord-302530-pp6bl941 756 29 in in IN cord-302530-pp6bl941 756 30 binding binding NN cord-302530-pp6bl941 756 31 of of IN cord-302530-pp6bl941 756 32 WEEV WEEV NNP cord-302530-pp6bl941 756 33 to to IN cord-302530-pp6bl941 756 34 mosquito mosquito NNP cord-302530-pp6bl941 756 35 midguts midgut NNS cord-302530-pp6bl941 756 36 . . . cord-302530-pp6bl941 757 1 Very very RB cord-302530-pp6bl941 757 2 large large JJ cord-302530-pp6bl941 757 3 negative negative JJ cord-302530-pp6bl941 757 4 values value NNS cord-302530-pp6bl941 757 5 of of IN cord-302530-pp6bl941 757 6 ΔC ΔC NNP cord-302530-pp6bl941 757 7 p p NN cord-302530-pp6bl941 757 8 for for IN cord-302530-pp6bl941 758 1 protein protein NN cord-302530-pp6bl941 758 2 / / SYM cord-302530-pp6bl941 758 3 protein protein NN cord-302530-pp6bl941 758 4 GP GP NNP cord-302530-pp6bl941 758 5 / / SYM cord-302530-pp6bl941 758 6 Cr cr NN cord-302530-pp6bl941 758 7 interactions interaction NNS cord-302530-pp6bl941 758 8 are be VBP cord-302530-pp6bl941 758 9 predicted predict VBN cord-302530-pp6bl941 758 10 to to TO cord-302530-pp6bl941 758 11 diminish diminish VB cord-302530-pp6bl941 758 12 arbovirus arbovirus NN cord-302530-pp6bl941 758 13 transmission transmission NN cord-302530-pp6bl941 758 14 at at IN cord-302530-pp6bl941 758 15 low low JJ cord-302530-pp6bl941 758 16 temperatures temperature NNS cord-302530-pp6bl941 758 17 compared compare VBN cord-302530-pp6bl941 758 18 to to IN cord-302530-pp6bl941 758 19 the the DT cord-302530-pp6bl941 758 20 HA HA NNP cord-302530-pp6bl941 758 21 / / SYM cord-302530-pp6bl941 758 22 SA sa NN cord-302530-pp6bl941 758 23 glycan glycan NN cord-302530-pp6bl941 758 24 interaction interaction NN cord-302530-pp6bl941 758 25 for for IN cord-302530-pp6bl941 758 26 which which WDT cord-302530-pp6bl941 758 27 ΔC ΔC NNP cord-302530-pp6bl941 758 28 p p NNP cord-302530-pp6bl941 758 29 is be VBZ cord-302530-pp6bl941 758 30 negligible negligible JJ cord-302530-pp6bl941 758 31 . . . cord-302530-pp6bl941 759 1 Thus thus RB cord-302530-pp6bl941 759 2 selecting select VBG cord-302530-pp6bl941 759 3 for for IN cord-302530-pp6bl941 759 4 SA sa NN cord-302530-pp6bl941 759 5 glycan glycan NN cord-302530-pp6bl941 759 6 interactions interaction NNS cord-302530-pp6bl941 759 7 as as IN cord-302530-pp6bl941 759 8 reported report VBN cord-302530-pp6bl941 759 9 for for IN cord-302530-pp6bl941 759 10 BTV BTV NNP cord-302530-pp6bl941 759 11 binding binding NN cord-302530-pp6bl941 759 12 may may MD cord-302530-pp6bl941 759 13 be be VB cord-302530-pp6bl941 759 14 a a DT cord-302530-pp6bl941 759 15 mechanism mechanism NN cord-302530-pp6bl941 759 16 to to TO cord-302530-pp6bl941 759 17 allow allow VB cord-302530-pp6bl941 759 18 transmission transmission NN cord-302530-pp6bl941 759 19 at at IN cord-302530-pp6bl941 759 20 the the DT cord-302530-pp6bl941 759 21 lower low JJR cord-302530-pp6bl941 759 22 temperatures temperature NNS cord-302530-pp6bl941 759 23 experienced experience VBN cord-302530-pp6bl941 759 24 by by IN cord-302530-pp6bl941 759 25 arboviruses arbovirus NNS cord-302530-pp6bl941 759 26 infecting infect VBG cord-302530-pp6bl941 759 27 arthropods arthropod NNS cord-302530-pp6bl941 759 28 in in IN cord-302530-pp6bl941 759 29 temperate temperate JJ cord-302530-pp6bl941 759 30 regions region NNS cord-302530-pp6bl941 759 31 of of IN cord-302530-pp6bl941 759 32 the the DT cord-302530-pp6bl941 759 33 world world NN cord-302530-pp6bl941 759 34 . . . cord-302530-pp6bl941 760 1 The the DT cord-302530-pp6bl941 760 2 magnitude magnitude NN cord-302530-pp6bl941 760 3 of of IN cord-302530-pp6bl941 760 4 ΔS ΔS NNP cord-302530-pp6bl941 760 5 a_immob a_immob NNP cord-302530-pp6bl941 760 6 is be VBZ cord-302530-pp6bl941 760 7 currently currently RB cord-302530-pp6bl941 760 8 unknown unknown JJ cord-302530-pp6bl941 760 9 but but CC cord-302530-pp6bl941 760 10 is be VBZ cord-302530-pp6bl941 760 11 predicted predict VBN cord-302530-pp6bl941 760 12 to to TO cord-302530-pp6bl941 760 13 be be VB cord-302530-pp6bl941 760 14 large large JJ cord-302530-pp6bl941 760 15 and and CC cord-302530-pp6bl941 760 16 negative negative JJ cord-302530-pp6bl941 760 17 and and CC cord-302530-pp6bl941 760 18 to to TO cord-302530-pp6bl941 760 19 be be VB cord-302530-pp6bl941 760 20 more more RBR cord-302530-pp6bl941 760 21 negative negative JJ cord-302530-pp6bl941 760 22 for for IN cord-302530-pp6bl941 760 23 larger large JJR cord-302530-pp6bl941 760 24 viruses virus NNS cord-302530-pp6bl941 760 25 such such JJ cord-302530-pp6bl941 760 26 as as IN cord-302530-pp6bl941 760 27 HIV HIV NNP cord-302530-pp6bl941 761 1 ( ( -LRB- cord-302530-pp6bl941 761 2 mean mean UH cord-302530-pp6bl941 761 3 diameter diameter NN cord-302530-pp6bl941 761 4 134 134 CD cord-302530-pp6bl941 761 5 nm nm NN cord-302530-pp6bl941 761 6 ) ) -RRB- cord-302530-pp6bl941 761 7 compared compare VBN cord-302530-pp6bl941 761 8 to to IN cord-302530-pp6bl941 761 9 the the DT cord-302530-pp6bl941 761 10 smaller small JJR cord-302530-pp6bl941 761 11 arboviruses arbovirus NNS cord-302530-pp6bl941 761 12 ( ( -LRB- cord-302530-pp6bl941 761 13 diameter diameter NN cord-302530-pp6bl941 761 14 50 50 CD cord-302530-pp6bl941 761 15 to to TO cord-302530-pp6bl941 761 16 70 70 CD cord-302530-pp6bl941 761 17 nm nm NN cord-302530-pp6bl941 761 18 ) ) -RRB- cord-302530-pp6bl941 761 19 . . . cord-302530-pp6bl941 762 1 Small small JJ cord-302530-pp6bl941 762 2 virion virion NN cord-302530-pp6bl941 762 3 diameter diameter NN cord-302530-pp6bl941 762 4 through through IN cord-302530-pp6bl941 762 5 a a DT cord-302530-pp6bl941 762 6 less less RBR cord-302530-pp6bl941 762 7 negative negative JJ cord-302530-pp6bl941 762 8 ΔS ΔS NNP cord-302530-pp6bl941 762 9 a_immob a_immob NNP cord-302530-pp6bl941 762 10 , , , cord-302530-pp6bl941 762 11 favours favour VBZ cord-302530-pp6bl941 762 12 virus virus NN cord-302530-pp6bl941 762 13 binding bind VBG cord-302530-pp6bl941 762 14 at at IN cord-302530-pp6bl941 762 15 higher high JJR cord-302530-pp6bl941 762 16 temperatures temperature NNS cord-302530-pp6bl941 762 17 giving give VBG cord-302530-pp6bl941 762 18 smaller small JJR cord-302530-pp6bl941 762 19 viruses virus NNS cord-302530-pp6bl941 762 20 a a DT cord-302530-pp6bl941 762 21 selective selective JJ cord-302530-pp6bl941 762 22 advantage advantage NN cord-302530-pp6bl941 762 23 for for IN cord-302530-pp6bl941 762 24 infecting infect VBG cord-302530-pp6bl941 762 25 hosts host NNS cord-302530-pp6bl941 762 26 at at IN cord-302530-pp6bl941 762 27 the the DT cord-302530-pp6bl941 762 28 higher high JJR cord-302530-pp6bl941 762 29 body body NN cord-302530-pp6bl941 762 30 temperatures temperature NNS cord-302530-pp6bl941 762 31 of of IN cord-302530-pp6bl941 762 32 mammals mammal NNS cord-302530-pp6bl941 762 33 and and CC cord-302530-pp6bl941 762 34 birds bird NNS cord-302530-pp6bl941 762 35 . . . cord-302530-pp6bl941 763 1 This this DT cord-302530-pp6bl941 763 2 is be VBZ cord-302530-pp6bl941 763 3 in in IN cord-302530-pp6bl941 763 4 agreement agreement NN cord-302530-pp6bl941 763 5 with with IN cord-302530-pp6bl941 763 6 the the DT cord-302530-pp6bl941 763 7 published publish VBN cord-302530-pp6bl941 763 8 observational observational JJ cord-302530-pp6bl941 763 9 findings finding NNS cord-302530-pp6bl941 763 10 that that IN cord-302530-pp6bl941 763 11 virus virus NN cord-302530-pp6bl941 763 12 volume volume NN cord-302530-pp6bl941 763 13 decreases decrease VBZ cord-302530-pp6bl941 763 14 with with IN cord-302530-pp6bl941 763 15 increasing increase VBG cord-302530-pp6bl941 763 16 host host NN cord-302530-pp6bl941 763 17 temperature temperature NN cord-302530-pp6bl941 763 18 in in IN cord-302530-pp6bl941 763 19 the the DT cord-302530-pp6bl941 763 20 case case NN cord-302530-pp6bl941 763 21 of of IN cord-302530-pp6bl941 763 22 dsDNA dsdna JJ cord-302530-pp6bl941 763 23 viruses virus NNS cord-302530-pp6bl941 763 24 . . . cord-302530-pp6bl941 764 1 In in IN cord-302530-pp6bl941 764 2 the the DT cord-302530-pp6bl941 764 3 case case NN cord-302530-pp6bl941 764 4 of of IN cord-302530-pp6bl941 764 5 HIV HIV NNP cord-302530-pp6bl941 764 6 , , , cord-302530-pp6bl941 764 7 the the DT cord-302530-pp6bl941 764 8 unfavourable unfavourable JJ cord-302530-pp6bl941 764 9 effect effect NN cord-302530-pp6bl941 764 10 at at IN cord-302530-pp6bl941 764 11 human human JJ cord-302530-pp6bl941 764 12 body body NN cord-302530-pp6bl941 764 13 temperature temperature NN cord-302530-pp6bl941 764 14 of of IN cord-302530-pp6bl941 764 15 the the DT cord-302530-pp6bl941 764 16 large large JJ cord-302530-pp6bl941 764 17 negative negative JJ cord-302530-pp6bl941 764 18 ΔS ΔS NNP cord-302530-pp6bl941 764 19 a_immob a_immob NNP cord-302530-pp6bl941 764 20 value value NN cord-302530-pp6bl941 764 21 due due IN cord-302530-pp6bl941 764 22 to to IN cord-302530-pp6bl941 764 23 the the DT cord-302530-pp6bl941 764 24 large large JJ cord-302530-pp6bl941 764 25 size size NN cord-302530-pp6bl941 764 26 of of IN cord-302530-pp6bl941 764 27 the the DT cord-302530-pp6bl941 764 28 virus virus NN cord-302530-pp6bl941 764 29 may may MD cord-302530-pp6bl941 764 30 be be VB cord-302530-pp6bl941 764 31 overcome overcome VBN cord-302530-pp6bl941 764 32 by by IN cord-302530-pp6bl941 764 33 non non JJ cord-302530-pp6bl941 764 34 - - JJ cord-302530-pp6bl941 764 35 specific specific JJ cord-302530-pp6bl941 764 36 binding binding NN cord-302530-pp6bl941 764 37 . . . cord-302530-pp6bl941 765 1 It -PRON- PRP cord-302530-pp6bl941 765 2 is be VBZ cord-302530-pp6bl941 765 3 proposed propose VBN cord-302530-pp6bl941 765 4 here here RB cord-302530-pp6bl941 765 5 that that IN cord-302530-pp6bl941 765 6 non non JJ cord-302530-pp6bl941 765 7 - - JJ cord-302530-pp6bl941 765 8 specific specific JJ cord-302530-pp6bl941 765 9 binding binding NN cord-302530-pp6bl941 765 10 of of IN cord-302530-pp6bl941 765 11 HIV HIV NNP cord-302530-pp6bl941 765 12 as as IN cord-302530-pp6bl941 765 13 the the DT cord-302530-pp6bl941 765 14 virus virus NN cord-302530-pp6bl941 765 15 first first RB cord-302530-pp6bl941 765 16 randomly randomly RB cord-302530-pp6bl941 765 17 attaches attach VBZ cord-302530-pp6bl941 765 18 to to IN cord-302530-pp6bl941 765 19 a a DT cord-302530-pp6bl941 765 20 host host NN cord-302530-pp6bl941 765 21 CD4 CD4 NNP cord-302530-pp6bl941 765 22 + + CC cord-302530-pp6bl941 765 23 T T NNP cord-302530-pp6bl941 765 24 cell cell NN cord-302530-pp6bl941 765 25 surface surface NN cord-302530-pp6bl941 765 26 takes take VBZ cord-302530-pp6bl941 765 27 a a DT cord-302530-pp6bl941 765 28 large large JJ cord-302530-pp6bl941 765 29 proportion proportion NN cord-302530-pp6bl941 765 30 ( ( -LRB- cord-302530-pp6bl941 765 31 represented represent VBN cord-302530-pp6bl941 765 32 by by IN cord-302530-pp6bl941 765 33 ΔS ΔS NNP cord-302530-pp6bl941 765 34 a_non_specific a_non_specific NNP cord-302530-pp6bl941 765 35 ) ) -RRB- cord-302530-pp6bl941 765 36 of of IN cord-302530-pp6bl941 765 37 the the DT cord-302530-pp6bl941 765 38 entropy entropy NN cord-302530-pp6bl941 765 39 loss loss NN cord-302530-pp6bl941 765 40 of of IN cord-302530-pp6bl941 765 41 ΔS ΔS NNP cord-302530-pp6bl941 765 42 a_immob a_immob NNP cord-302530-pp6bl941 765 43 such such JJ cord-302530-pp6bl941 765 44 that that IN cord-302530-pp6bl941 765 45 HIV HIV NNP cord-302530-pp6bl941 765 46 can can MD cord-302530-pp6bl941 765 47 then then RB cord-302530-pp6bl941 765 48 bind bind VB cord-302530-pp6bl941 765 49 specifically specifically RB cord-302530-pp6bl941 765 50 through through IN cord-302530-pp6bl941 765 51 Env Env NNP cord-302530-pp6bl941 765 52 : : : cord-302530-pp6bl941 766 1 CD4 CD4 NNP cord-302530-pp6bl941 766 2 interactions interaction NNS cord-302530-pp6bl941 766 3 at at IN cord-302530-pp6bl941 766 4 the the DT cord-302530-pp6bl941 766 5 relatively relatively RB cord-302530-pp6bl941 766 6 high high JJ cord-302530-pp6bl941 766 7 temperature temperature NN cord-302530-pp6bl941 766 8 of of IN cord-302530-pp6bl941 766 9 the the DT cord-302530-pp6bl941 766 10 human human JJ cord-302530-pp6bl941 766 11 body body NN cord-302530-pp6bl941 766 12 . . . cord-302530-pp6bl941 767 1 The the DT cord-302530-pp6bl941 767 2 randomly randomly RB cord-302530-pp6bl941 767 3 attached attach VBN cord-302530-pp6bl941 767 4 virus virus NN cord-302530-pp6bl941 767 5 " " `` cord-302530-pp6bl941 767 6 rolls roll VBZ cord-302530-pp6bl941 767 7 into into IN cord-302530-pp6bl941 767 8 place place NN cord-302530-pp6bl941 767 9 " " `` cord-302530-pp6bl941 767 10 driven drive VBN cord-302530-pp6bl941 767 11 by by IN cord-302530-pp6bl941 767 12 n n NN cord-302530-pp6bl941 767 13 = = SYM cord-302530-pp6bl941 767 14 3 3 CD cord-302530-pp6bl941 767 15 specific specific JJ cord-302530-pp6bl941 767 16 Env env NN cord-302530-pp6bl941 767 17 : : : cord-302530-pp6bl941 768 1 CD4 CD4 NNP cord-302530-pp6bl941 768 2 interactions interaction NNS cord-302530-pp6bl941 768 3 resulting result VBG cord-302530-pp6bl941 768 4 in in IN cord-302530-pp6bl941 768 5 a a DT cord-302530-pp6bl941 768 6 further further JJ cord-302530-pp6bl941 768 7 entropy entropy NN cord-302530-pp6bl941 768 8 loss loss NN cord-302530-pp6bl941 768 9 ( ( -LRB- cord-302530-pp6bl941 768 10 ΔS ΔS NNP cord-302530-pp6bl941 768 11 a_specific a_specific NNP cord-302530-pp6bl941 768 12 ) ) -RRB- cord-302530-pp6bl941 768 13 as as IN cord-302530-pp6bl941 768 14 the the DT cord-302530-pp6bl941 768 15 virus virus NN cord-302530-pp6bl941 768 16 particle particle NN cord-302530-pp6bl941 768 17 takes take VBZ cord-302530-pp6bl941 768 18 up up RP cord-302530-pp6bl941 768 19 a a DT cord-302530-pp6bl941 768 20 specific specific JJ cord-302530-pp6bl941 768 21 orientation orientation NN cord-302530-pp6bl941 768 22 ready ready JJ cord-302530-pp6bl941 768 23 for for IN cord-302530-pp6bl941 768 24 viral viral JJ cord-302530-pp6bl941 768 25 entry entry NN cord-302530-pp6bl941 768 26 . . . cord-302530-pp6bl941 769 1 Non non JJ cord-302530-pp6bl941 769 2 - - JJ cord-302530-pp6bl941 769 3 specific specific JJ cord-302530-pp6bl941 769 4 attachment attachment NN cord-302530-pp6bl941 769 5 factors factor NNS cord-302530-pp6bl941 769 6 are be VBP cord-302530-pp6bl941 769 7 all all PDT cord-302530-pp6bl941 769 8 the the DT cord-302530-pp6bl941 769 9 more more RBR cord-302530-pp6bl941 769 10 important important JJ cord-302530-pp6bl941 769 11 for for IN cord-302530-pp6bl941 769 12 a a DT cord-302530-pp6bl941 769 13 GP GP NNP cord-302530-pp6bl941 769 14 / / SYM cord-302530-pp6bl941 769 15 Cr cr NN cord-302530-pp6bl941 769 16 system system NN cord-302530-pp6bl941 769 17 such such JJ cord-302530-pp6bl941 769 18 as as IN cord-302530-pp6bl941 769 19 the the DT cord-302530-pp6bl941 769 20 HIV HIV NNP cord-302530-pp6bl941 769 21 Env Env NNP cord-302530-pp6bl941 769 22 : : : cord-302530-pp6bl941 769 23 CD4 CD4 NNP cord-302530-pp6bl941 769 24 interaction interaction NN cord-302530-pp6bl941 769 25 for for IN cord-302530-pp6bl941 769 26 which which WDT cord-302530-pp6bl941 769 27 ΔC ΔC NNP cord-302530-pp6bl941 769 28 p p NNP cord-302530-pp6bl941 769 29 is be VBZ cord-302530-pp6bl941 769 30 large large JJ cord-302530-pp6bl941 769 31 and and CC cord-302530-pp6bl941 769 32 negative negative JJ cord-302530-pp6bl941 769 33 and and CC cord-302530-pp6bl941 769 34 diminishes diminish VBZ cord-302530-pp6bl941 769 35 binding bind VBG cord-302530-pp6bl941 769 36 at at IN cord-302530-pp6bl941 769 37 higher high JJR cord-302530-pp6bl941 769 38 temperatures temperature NNS cord-302530-pp6bl941 769 39 . . . cord-302530-pp6bl941 770 1 It -PRON- PRP cord-302530-pp6bl941 770 2 is be VBZ cord-302530-pp6bl941 770 3 concluded conclude VBN cord-302530-pp6bl941 770 4 that that IN cord-302530-pp6bl941 770 5 experimental experimental JJ cord-302530-pp6bl941 770 6 data datum NNS cord-302530-pp6bl941 770 7 on on IN cord-302530-pp6bl941 770 8 ΔS ΔS NNP cord-302530-pp6bl941 770 9 a_immob a_immob NNP cord-302530-pp6bl941 770 10 should should MD cord-302530-pp6bl941 770 11 be be VB cord-302530-pp6bl941 770 12 obtained obtain VBN cord-302530-pp6bl941 770 13 and and CC cord-302530-pp6bl941 770 14 antiviral antiviral JJ cord-302530-pp6bl941 770 15 therapeutic therapeutic JJ cord-302530-pp6bl941 770 16 strategies strategy NNS cord-302530-pp6bl941 770 17 , , , cord-302530-pp6bl941 770 18 for for IN cord-302530-pp6bl941 770 19 example example NN cord-302530-pp6bl941 770 20 using use VBG cord-302530-pp6bl941 770 21 zinc zinc NN cord-302530-pp6bl941 770 22 oxide oxide NN cord-302530-pp6bl941 770 23 nanoparticles nanoparticle NNS cord-302530-pp6bl941 770 24 for for IN cord-302530-pp6bl941 770 25 herpes herpes NN cord-302530-pp6bl941 770 26 simplex simplex NNP cord-302530-pp6bl941 770 27 virus virus NN cord-302530-pp6bl941 770 28 or or CC cord-302530-pp6bl941 770 29 neutralising neutralise VBG cord-302530-pp6bl941 770 30 antibodies antibody NNS cord-302530-pp6bl941 770 31 to to TO cord-302530-pp6bl941 770 32 block block VB cord-302530-pp6bl941 770 33 virus virus NN cord-302530-pp6bl941 770 34 binding binding NN cord-302530-pp6bl941 770 35 , , , cord-302530-pp6bl941 770 36 should should MD cord-302530-pp6bl941 770 37 focus focus VB cord-302530-pp6bl941 770 38 not not RB cord-302530-pp6bl941 770 39 only only RB cord-302530-pp6bl941 770 40 on on IN cord-302530-pp6bl941 770 41 blocking block VBG cord-302530-pp6bl941 770 42 the the DT cord-302530-pp6bl941 770 43 Cr cr NN cord-302530-pp6bl941 770 44 - - HYPH cord-302530-pp6bl941 770 45 binding bind VBG cord-302530-pp6bl941 770 46 sites site NNS cord-302530-pp6bl941 770 47 on on IN cord-302530-pp6bl941 770 48 the the DT cord-302530-pp6bl941 770 49 GP gp NN cord-302530-pp6bl941 770 50 molecules molecule NNS cord-302530-pp6bl941 770 51 themselves -PRON- PRP cord-302530-pp6bl941 770 52 but but CC cord-302530-pp6bl941 770 53 also also RB cord-302530-pp6bl941 770 54 on on IN cord-302530-pp6bl941 770 55 targeting target VBG cord-302530-pp6bl941 770 56 ΔS ΔS NNP cord-302530-pp6bl941 770 57 a_immob a_immob NNP cord-302530-pp6bl941 770 58 by by IN cord-302530-pp6bl941 770 59 increasing increase VBG cord-302530-pp6bl941 770 60 the the DT cord-302530-pp6bl941 770 61 size size NN cord-302530-pp6bl941 770 62 of of IN cord-302530-pp6bl941 770 63 the the DT cord-302530-pp6bl941 770 64 virus virus NN cord-302530-pp6bl941 770 65 itself -PRON- PRP cord-302530-pp6bl941 770 66 and and CC cord-302530-pp6bl941 770 67 so so RB cord-302530-pp6bl941 770 68 minimising minimise VBG cord-302530-pp6bl941 770 69 host host NN cord-302530-pp6bl941 770 70 cell cell NN cord-302530-pp6bl941 770 71 binding bind VBG cord-302530-pp6bl941 770 72 affinity affinity NN cord-302530-pp6bl941 770 73 at at IN cord-302530-pp6bl941 770 74 human human JJ cord-302530-pp6bl941 770 75 body body NN cord-302530-pp6bl941 770 76 temperatures temperature NNS cord-302530-pp6bl941 770 77 according accord VBG cord-302530-pp6bl941 770 78 to to IN cord-302530-pp6bl941 770 79 the the DT cord-302530-pp6bl941 770 80 model model NN cord-302530-pp6bl941 770 81 here here RB cord-302530-pp6bl941 770 82 . . . cord-302530-pp6bl941 771 1 Bacterial bacterial JJ cord-302530-pp6bl941 771 2 cells cell NNS cord-302530-pp6bl941 771 3 are be VBP cord-302530-pp6bl941 771 4 larger large JJR cord-302530-pp6bl941 771 5 than than IN cord-302530-pp6bl941 771 6 viruses virus NNS cord-302530-pp6bl941 771 7 and and CC cord-302530-pp6bl941 771 8 ΔS ΔS NNP cord-302530-pp6bl941 771 9 a_immob a_immob NNP cord-302530-pp6bl941 771 10 would would MD cord-302530-pp6bl941 771 11 be be VB cord-302530-pp6bl941 771 12 expected expect VBN cord-302530-pp6bl941 771 13 to to TO cord-302530-pp6bl941 771 14 be be VB cord-302530-pp6bl941 771 15 more more RBR cord-302530-pp6bl941 771 16 negative negative JJ cord-302530-pp6bl941 771 17 . . . cord-302530-pp6bl941 772 1 Targeting target VBG cord-302530-pp6bl941 772 2 ΔS ΔS NNP cord-302530-pp6bl941 772 3 a_immob a_immob NNP cord-302530-pp6bl941 772 4 may may MD cord-302530-pp6bl941 772 5 also also RB cord-302530-pp6bl941 772 6 have have VB cord-302530-pp6bl941 772 7 application application NN cord-302530-pp6bl941 772 8 as as IN cord-302530-pp6bl941 772 9 an an DT cord-302530-pp6bl941 772 10 alternative alternative JJ cord-302530-pp6bl941 772 11 approach approach NN cord-302530-pp6bl941 772 12 to to IN cord-302530-pp6bl941 772 13 antibiotics antibiotic NNS cord-302530-pp6bl941 772 14 for for IN cord-302530-pp6bl941 772 15 bacterial bacterial JJ cord-302530-pp6bl941 772 16 pathogens pathogen NNS cord-302530-pp6bl941 772 17 when when WRB cord-302530-pp6bl941 772 18 bacterial bacterial JJ cord-302530-pp6bl941 772 19 pathogenesis pathogenesis NN cord-302530-pp6bl941 772 20 depends depend VBZ cord-302530-pp6bl941 772 21 on on IN cord-302530-pp6bl941 772 22 attachment attachment NN cord-302530-pp6bl941 772 23 to to IN cord-302530-pp6bl941 772 24 cells cell NNS cord-302530-pp6bl941 772 25 . . . cord-302530-pp6bl941 773 1 However however RB cord-302530-pp6bl941 773 2 , , , cord-302530-pp6bl941 773 3 it -PRON- PRP cord-302530-pp6bl941 773 4 should should MD cord-302530-pp6bl941 773 5 be be VB cord-302530-pp6bl941 773 6 noted note VBN cord-302530-pp6bl941 773 7 that that IN cord-302530-pp6bl941 773 8 ΔS ΔS NNP cord-302530-pp6bl941 773 9 a_immob a_immob NNP cord-302530-pp6bl941 773 10 decreases decrease VBZ cord-302530-pp6bl941 773 11 logarithmically logarithmically RB cord-302530-pp6bl941 773 12 ( ( -LRB- cord-302530-pp6bl941 773 13 i.e. i.e. FW cord-302530-pp6bl941 773 14 slowly slowly RB cord-302530-pp6bl941 773 15 ) ) -RRB- cord-302530-pp6bl941 773 16 with with IN cord-302530-pp6bl941 773 17 increasing increase VBG cord-302530-pp6bl941 773 18 size size NN cord-302530-pp6bl941 773 19 which which WDT cord-302530-pp6bl941 773 20 may may MD cord-302530-pp6bl941 773 21 limit limit VB cord-302530-pp6bl941 773 22 the the DT cord-302530-pp6bl941 773 23 practicability practicability NN cord-302530-pp6bl941 773 24 to to IN cord-302530-pp6bl941 773 25 bacteria bacteria NNS cord-302530-pp6bl941 773 26 . . . cord-302530-pp6bl941 774 1 Prophylactic prophylactic JJ cord-302530-pp6bl941 774 2 , , , cord-302530-pp6bl941 774 3 therapeutic therapeutic JJ cord-302530-pp6bl941 774 4 and and CC cord-302530-pp6bl941 774 5 neutralizing neutralize VBG cord-302530-pp6bl941 774 6 effects effect NNS cord-302530-pp6bl941 774 7 of of IN cord-302530-pp6bl941 774 8 zinc zinc NN cord-302530-pp6bl941 774 9 oxide oxide NN cord-302530-pp6bl941 774 10 tetrapod tetrapod NN cord-302530-pp6bl941 774 11 structures structure NNS cord-302530-pp6bl941 774 12 against against IN cord-302530-pp6bl941 774 13 herpes herpes NNP cord-302530-pp6bl941 774 14 simplex simplex NNP cord-302530-pp6bl941 774 15 virus virus NN cord-302530-pp6bl941 774 16 type-2 type-2 NN cord-302530-pp6bl941 774 17 infection infection NN cord-302530-pp6bl941 775 1 The the DT cord-302530-pp6bl941 775 2 organisation organisation NN cord-302530-pp6bl941 775 3 of of IN cord-302530-pp6bl941 775 4 Ebola Ebola NNP cord-302530-pp6bl941 775 5 virus virus NN cord-302530-pp6bl941 775 6 reveals reveal VBZ cord-302530-pp6bl941 775 7 a a DT cord-302530-pp6bl941 775 8 capacity capacity NN cord-302530-pp6bl941 775 9 for for IN cord-302530-pp6bl941 775 10 extensive extensive JJ cord-302530-pp6bl941 775 11 modular modular JJ cord-302530-pp6bl941 775 12 polyploidy polyploidy NN cord-302530-pp6bl941 775 13 Diverse Diverse NNP cord-302530-pp6bl941 775 14 rna rna NNP cord-302530-pp6bl941 775 15 viruses virus NNS cord-302530-pp6bl941 775 16 of of IN cord-302530-pp6bl941 775 17 arthropod arthropod JJ cord-302530-pp6bl941 775 18 origin origin NN cord-302530-pp6bl941 775 19 in in IN cord-302530-pp6bl941 775 20 the the DT cord-302530-pp6bl941 775 21 blood blood NN cord-302530-pp6bl941 775 22 of of IN cord-302530-pp6bl941 775 23 fruit fruit NN cord-302530-pp6bl941 775 24 bats bat NNS cord-302530-pp6bl941 775 25 suggest suggest VBP cord-302530-pp6bl941 775 26 a a DT cord-302530-pp6bl941 775 27 link link NN cord-302530-pp6bl941 775 28 between between IN cord-302530-pp6bl941 775 29 bat bat NN cord-302530-pp6bl941 775 30 and and CC cord-302530-pp6bl941 775 31 arthropod arthropod NN cord-302530-pp6bl941 775 32 viromes virome VBZ cord-302530-pp6bl941 775 33 Different different JJ cord-302530-pp6bl941 775 34 infectivity infectivity NN cord-302530-pp6bl941 775 35 of of IN cord-302530-pp6bl941 775 36 HIV-1 HIV-1 NNP cord-302530-pp6bl941 775 37 strains strain NNS cord-302530-pp6bl941 775 38 is be VBZ cord-302530-pp6bl941 775 39 linked link VBN cord-302530-pp6bl941 775 40 to to IN cord-302530-pp6bl941 775 41 number number NN cord-302530-pp6bl941 775 42 of of IN cord-302530-pp6bl941 775 43 envelope envelope NN cord-302530-pp6bl941 775 44 trimers trimer NNS cord-302530-pp6bl941 775 45 required require VBN cord-302530-pp6bl941 775 46 for for IN cord-302530-pp6bl941 775 47 entry entry NN cord-302530-pp6bl941 775 48 Changing change VBG cord-302530-pp6bl941 775 49 patterns pattern NNS cord-302530-pp6bl941 775 50 of of IN cord-302530-pp6bl941 775 51 west west NN cord-302530-pp6bl941 775 52 Nile Nile NNP cord-302530-pp6bl941 775 53 virus virus NN cord-302530-pp6bl941 775 54 transmission transmission NN cord-302530-pp6bl941 775 55 : : : cord-302530-pp6bl941 775 56 altered alter VBN cord-302530-pp6bl941 775 57 vector vector NN cord-302530-pp6bl941 775 58 competence competence NN cord-302530-pp6bl941 775 59 and and CC cord-302530-pp6bl941 775 60 host host NN cord-302530-pp6bl941 775 61 susceptibility susceptibility NN cord-302530-pp6bl941 775 62 Structural structural JJ cord-302530-pp6bl941 775 63 organization organization NN cord-302530-pp6bl941 775 64 of of IN cord-302530-pp6bl941 775 65 authentic authentic JJ cord-302530-pp6bl941 775 66 , , , cord-302530-pp6bl941 775 67 mature mature VB cord-302530-pp6bl941 775 68 HIV-1 HIV-1 NNP cord-302530-pp6bl941 775 69 virions virion NNS cord-302530-pp6bl941 775 70 and and CC cord-302530-pp6bl941 775 71 cores core NNS cord-302530-pp6bl941 775 72 Sequential sequential JJ cord-302530-pp6bl941 775 73 bottlenecks bottleneck NNS cord-302530-pp6bl941 775 74 drive drive VBP cord-302530-pp6bl941 775 75 viral viral JJ cord-302530-pp6bl941 775 76 evolution evolution NN cord-302530-pp6bl941 775 77 in in IN cord-302530-pp6bl941 775 78 early early JJ cord-302530-pp6bl941 775 79 acute acute JJ cord-302530-pp6bl941 775 80 hepatitis hepatitis NN cord-302530-pp6bl941 775 81 c c NN cord-302530-pp6bl941 775 82 virus virus NN cord-302530-pp6bl941 775 83 infection infection NN cord-302530-pp6bl941 775 84 Membrane Membrane NNP cord-302530-pp6bl941 775 85 recognition recognition NN cord-302530-pp6bl941 775 86 by by IN cord-302530-pp6bl941 775 87 vesicular vesicular JJ cord-302530-pp6bl941 775 88 stomatitis stomatitis NN cord-302530-pp6bl941 775 89 virus virus NN cord-302530-pp6bl941 775 90 involves involve VBZ cord-302530-pp6bl941 775 91 enthalphy enthalphy NN cord-302530-pp6bl941 775 92 - - HYPH cord-302530-pp6bl941 775 93 driven drive VBN cord-302530-pp6bl941 775 94 protein protein NN cord-302530-pp6bl941 775 95 - - HYPH cord-302530-pp6bl941 775 96 lipid lipid NN cord-302530-pp6bl941 775 97 interactions interaction NNS cord-302530-pp6bl941 775 98 Structure structure NN cord-302530-pp6bl941 775 99 - - HYPH cord-302530-pp6bl941 775 100 based base VBN cord-302530-pp6bl941 775 101 design design NN cord-302530-pp6bl941 775 102 of of IN cord-302530-pp6bl941 775 103 a a DT cord-302530-pp6bl941 775 104 soluble soluble JJ cord-302530-pp6bl941 775 105 prefusion prefusion NN cord-302530-pp6bl941 775 106 - - HYPH cord-302530-pp6bl941 775 107 closed close VBN cord-302530-pp6bl941 775 108 HIV-1 HIV-1 NNP cord-302530-pp6bl941 775 109 env env NN cord-302530-pp6bl941 775 110 trimer trimer NN cord-302530-pp6bl941 775 111 with with IN cord-302530-pp6bl941 775 112 reduced reduce VBN cord-302530-pp6bl941 775 113 CD4 CD4 NNP cord-302530-pp6bl941 775 114 affinity affinity NN cord-302530-pp6bl941 775 115 and and CC cord-302530-pp6bl941 775 116 improved improve VBD cord-302530-pp6bl941 775 117 immunogenicity immunogenicity JJ cord-302530-pp6bl941 775 118 Interdisciplinary interdisciplinary JJ cord-302530-pp6bl941 775 119 approaches approach NNS cord-302530-pp6bl941 775 120 to to IN cord-302530-pp6bl941 775 121 understanding understand VBG cord-302530-pp6bl941 775 122 disease disease NN cord-302530-pp6bl941 775 123 emergence emergence NN cord-302530-pp6bl941 775 124 : : : cord-302530-pp6bl941 775 125 the the DT cord-302530-pp6bl941 775 126 past past NN cord-302530-pp6bl941 775 127 , , , cord-302530-pp6bl941 775 128 present present JJ cord-302530-pp6bl941 775 129 , , , cord-302530-pp6bl941 775 130 and and CC cord-302530-pp6bl941 775 131 future future JJ cord-302530-pp6bl941 775 132 drivers driver NNS cord-302530-pp6bl941 775 133 of of IN cord-302530-pp6bl941 775 134 Nipah Nipah NNP cord-302530-pp6bl941 775 135 virus virus NN cord-302530-pp6bl941 775 136 emergence emergence NN cord-302530-pp6bl941 775 137 Role role NN cord-302530-pp6bl941 775 138 of of IN cord-302530-pp6bl941 775 139 receptor receptor NN cord-302530-pp6bl941 775 140 binding bind VBG cord-302530-pp6bl941 775 141 specificity specificity NN cord-302530-pp6bl941 775 142 in in IN cord-302530-pp6bl941 775 143 influenza influenza NN cord-302530-pp6bl941 776 1 a a DT cord-302530-pp6bl941 776 2 virus virus NN cord-302530-pp6bl941 776 3 transmission transmission NN cord-302530-pp6bl941 776 4 and and CC cord-302530-pp6bl941 776 5 pathogenesis pathogenesis NN cord-302530-pp6bl941 776 6 Characterization characterization NN cord-302530-pp6bl941 776 7 of of IN cord-302530-pp6bl941 776 8 human human JJ cord-302530-pp6bl941 776 9 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 776 10 virus virus NN cord-302530-pp6bl941 776 11 type type NN cord-302530-pp6bl941 776 12 1 1 CD cord-302530-pp6bl941 776 13 monomeric monomeric JJ cord-302530-pp6bl941 776 14 and and CC cord-302530-pp6bl941 776 15 trimeric trimeric JJ cord-302530-pp6bl941 776 16 gp120 gp120 NN cord-302530-pp6bl941 776 17 glycoproteins glycoprotein NNS cord-302530-pp6bl941 776 18 stabilized stabilize VBN cord-302530-pp6bl941 776 19 in in IN cord-302530-pp6bl941 776 20 the the DT cord-302530-pp6bl941 776 21 CD4-bound cd4-bound NN cord-302530-pp6bl941 776 22 state state NN cord-302530-pp6bl941 776 23 : : : cord-302530-pp6bl941 776 24 antigenicity antigenicity NN cord-302530-pp6bl941 776 25 , , , cord-302530-pp6bl941 776 26 biophysics biophysic NNS cord-302530-pp6bl941 776 27 , , , cord-302530-pp6bl941 776 28 and and CC cord-302530-pp6bl941 776 29 immunogenicity immunogenicity NN cord-302530-pp6bl941 776 30 Kinetics Kinetics NNP cord-302530-pp6bl941 776 31 of of IN cord-302530-pp6bl941 776 32 soluble soluble JJ cord-302530-pp6bl941 776 33 CD4 CD4 NNP cord-302530-pp6bl941 776 34 binding bind VBG cord-302530-pp6bl941 776 35 to to IN cord-302530-pp6bl941 776 36 cells cell NNS cord-302530-pp6bl941 776 37 expressing express VBG cord-302530-pp6bl941 776 38 human human JJ cord-302530-pp6bl941 776 39 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 776 40 virus virus NN cord-302530-pp6bl941 776 41 type type NN cord-302530-pp6bl941 776 42 1 1 CD cord-302530-pp6bl941 776 43 envelope envelope NN cord-302530-pp6bl941 776 44 glycoprotein glycoprotein NN cord-302530-pp6bl941 776 45 Use use NN cord-302530-pp6bl941 776 46 of of IN cord-302530-pp6bl941 776 47 a a DT cord-302530-pp6bl941 776 48 gp120 gp120 NN cord-302530-pp6bl941 776 49 binding bind VBG cord-302530-pp6bl941 776 50 assay assay NN cord-302530-pp6bl941 776 51 to to TO cord-302530-pp6bl941 776 52 dissect dissect VB cord-302530-pp6bl941 776 53 the the DT cord-302530-pp6bl941 776 54 requirements requirement NNS cord-302530-pp6bl941 776 55 and and CC cord-302530-pp6bl941 776 56 kinetics kinetic NNS cord-302530-pp6bl941 776 57 of of IN cord-302530-pp6bl941 776 58 human human JJ cord-302530-pp6bl941 776 59 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 776 60 virus virus NN cord-302530-pp6bl941 776 61 fusion fusion NN cord-302530-pp6bl941 776 62 events event NNS cord-302530-pp6bl941 776 63 Insights insight NNS cord-302530-pp6bl941 776 64 into into IN cord-302530-pp6bl941 776 65 protein protein NN cord-302530-pp6bl941 776 66 - - HYPH cord-302530-pp6bl941 776 67 ligand ligand NN cord-302530-pp6bl941 776 68 interactions interaction NNS cord-302530-pp6bl941 776 69 : : : cord-302530-pp6bl941 776 70 mechanisms mechanism NNS cord-302530-pp6bl941 776 71 , , , cord-302530-pp6bl941 776 72 models model NNS cord-302530-pp6bl941 776 73 , , , cord-302530-pp6bl941 776 74 and and CC cord-302530-pp6bl941 776 75 methods method NNS cord-302530-pp6bl941 776 76 Predicting predict VBG cord-302530-pp6bl941 776 77 first first JJ cord-302530-pp6bl941 776 78 traversal traversal NN cord-302530-pp6bl941 776 79 times time NNS cord-302530-pp6bl941 776 80 for for IN cord-302530-pp6bl941 776 81 virions virion NNS cord-302530-pp6bl941 776 82 and and CC cord-302530-pp6bl941 776 83 nanoparticles nanoparticle NNS cord-302530-pp6bl941 776 84 in in IN cord-302530-pp6bl941 776 85 mucus mucus NN cord-302530-pp6bl941 776 86 with with IN cord-302530-pp6bl941 776 87 slowed slow VBN cord-302530-pp6bl941 776 88 diffusion diffusion NN cord-302530-pp6bl941 776 89 Characterization characterization NN cord-302530-pp6bl941 776 90 of of IN cord-302530-pp6bl941 776 91 receptor receptor NN cord-302530-pp6bl941 776 92 binding bind VBG cord-302530-pp6bl941 776 93 profiles profile NNS cord-302530-pp6bl941 776 94 of of IN cord-302530-pp6bl941 776 95 influenza influenza NN cord-302530-pp6bl941 776 96 a a DT cord-302530-pp6bl941 776 97 viruses virus NNS cord-302530-pp6bl941 776 98 using use VBG cord-302530-pp6bl941 776 99 an an DT cord-302530-pp6bl941 776 100 ellipsometry ellipsometry NN cord-302530-pp6bl941 776 101 - - HYPH cord-302530-pp6bl941 776 102 based base VBN cord-302530-pp6bl941 776 103 label label NN cord-302530-pp6bl941 776 104 - - HYPH cord-302530-pp6bl941 776 105 free free JJ cord-302530-pp6bl941 776 106 glycan glycan NN cord-302530-pp6bl941 776 107 microarray microarray NN cord-302530-pp6bl941 776 108 assay assay NN cord-302530-pp6bl941 776 109 platform platform NN cord-302530-pp6bl941 776 110 Temperature temperature NN cord-302530-pp6bl941 776 111 dependence dependence NN cord-302530-pp6bl941 776 112 of of IN cord-302530-pp6bl941 776 113 cell cell NN cord-302530-pp6bl941 776 114 - - HYPH cord-302530-pp6bl941 776 115 cell cell NN cord-302530-pp6bl941 776 116 fusion fusion NN cord-302530-pp6bl941 776 117 induced induce VBN cord-302530-pp6bl941 776 118 by by IN cord-302530-pp6bl941 776 119 the the DT cord-302530-pp6bl941 776 120 envelope envelope NN cord-302530-pp6bl941 776 121 glycoprotein glycoprotein NN cord-302530-pp6bl941 776 122 of of IN cord-302530-pp6bl941 776 123 human human JJ cord-302530-pp6bl941 776 124 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 776 125 virus virus NN cord-302530-pp6bl941 776 126 type type NN cord-302530-pp6bl941 776 127 1 1 CD cord-302530-pp6bl941 776 128 Could Could MD cord-302530-pp6bl941 776 129 bat bat VB cord-302530-pp6bl941 776 130 cell cell NN cord-302530-pp6bl941 776 131 temperature temperature NN cord-302530-pp6bl941 776 132 and and CC cord-302530-pp6bl941 777 1 filovirus filovirus NNP cord-302530-pp6bl941 777 2 filament filament NN cord-302530-pp6bl941 777 3 length length NN cord-302530-pp6bl941 777 4 explain explain VB cord-302530-pp6bl941 777 5 the the DT cord-302530-pp6bl941 777 6 emergence emergence NN cord-302530-pp6bl941 777 7 of of IN cord-302530-pp6bl941 777 8 ebola ebola NNP cord-302530-pp6bl941 777 9 virus virus NN cord-302530-pp6bl941 777 10 in in IN cord-302530-pp6bl941 777 11 mammals mammal NNS cord-302530-pp6bl941 777 12 ? ? . cord-302530-pp6bl941 778 1 predictions prediction NNS cord-302530-pp6bl941 778 2 of of IN cord-302530-pp6bl941 778 3 a a DT cord-302530-pp6bl941 778 4 thermodynamic thermodynamic JJ cord-302530-pp6bl941 778 5 model model NN cord-302530-pp6bl941 778 6 Using use VBG cord-302530-pp6bl941 778 7 thermodynamic thermodynamic JJ cord-302530-pp6bl941 778 8 parameters parameter NNS cord-302530-pp6bl941 778 9 to to TO cord-302530-pp6bl941 778 10 calibrate calibrate VB cord-302530-pp6bl941 778 11 a a DT cord-302530-pp6bl941 778 12 mechanistic mechanistic JJ cord-302530-pp6bl941 778 13 dose dose NN cord-302530-pp6bl941 778 14 - - HYPH cord-302530-pp6bl941 778 15 response response NN cord-302530-pp6bl941 778 16 for for IN cord-302530-pp6bl941 778 17 infection infection NN cord-302530-pp6bl941 778 18 of of IN cord-302530-pp6bl941 778 19 a a DT cord-302530-pp6bl941 778 20 host host NN cord-302530-pp6bl941 778 21 by by IN cord-302530-pp6bl941 778 22 a a DT cord-302530-pp6bl941 778 23 virus virus NN cord-302530-pp6bl941 778 24 . . . cord-302530-pp6bl941 779 1 Microbial microbial JJ cord-302530-pp6bl941 779 2 Risk Risk NNP cord-302530-pp6bl941 779 3 Anal Anal NNP cord-302530-pp6bl941 779 4 Towards towards IN cord-302530-pp6bl941 779 5 a a DT cord-302530-pp6bl941 779 6 thermodynamic thermodynamic JJ cord-302530-pp6bl941 779 7 mechanistic mechanistic JJ cord-302530-pp6bl941 779 8 model model NN cord-302530-pp6bl941 779 9 for for IN cord-302530-pp6bl941 779 10 the the DT cord-302530-pp6bl941 779 11 effect effect NN cord-302530-pp6bl941 779 12 of of IN cord-302530-pp6bl941 779 13 temperature temperature NN cord-302530-pp6bl941 779 14 on on IN cord-302530-pp6bl941 779 15 arthropod arthropod JJ cord-302530-pp6bl941 779 16 vector vector NN cord-302530-pp6bl941 779 17 competence competence NN cord-302530-pp6bl941 779 18 for for IN cord-302530-pp6bl941 779 19 transmission transmission NN cord-302530-pp6bl941 779 20 of of IN cord-302530-pp6bl941 779 21 arbovirus arbovirus NN cord-302530-pp6bl941 779 22 High high JJ cord-302530-pp6bl941 779 23 viral viral JJ cord-302530-pp6bl941 779 24 load load NN cord-302530-pp6bl941 779 25 in in IN cord-302530-pp6bl941 779 26 semen semen NN cord-302530-pp6bl941 779 27 of of IN cord-302530-pp6bl941 779 28 human human JJ cord-302530-pp6bl941 779 29 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 779 30 virus virus NN cord-302530-pp6bl941 779 31 type type NN cord-302530-pp6bl941 779 32 1-infected 1-infected CD cord-302530-pp6bl941 779 33 men man NNS cord-302530-pp6bl941 779 34 at at IN cord-302530-pp6bl941 779 35 all all DT cord-302530-pp6bl941 779 36 stages stage NNS cord-302530-pp6bl941 779 37 of of IN cord-302530-pp6bl941 779 38 disease disease NN cord-302530-pp6bl941 779 39 and and CC cord-302530-pp6bl941 779 40 its -PRON- PRP$ cord-302530-pp6bl941 779 41 reduction reduction NN cord-302530-pp6bl941 779 42 by by IN cord-302530-pp6bl941 779 43 therapy therapy NN cord-302530-pp6bl941 779 44 with with IN cord-302530-pp6bl941 779 45 protease protease NN cord-302530-pp6bl941 779 46 and and CC cord-302530-pp6bl941 779 47 nonnucleoside nonnucleoside NN cord-302530-pp6bl941 779 48 reverse reverse NN cord-302530-pp6bl941 780 1 transcriptase transcriptase NNP cord-302530-pp6bl941 780 2 inhibitors inhibitor NNS cord-302530-pp6bl941 780 3 Adsorption Adsorption NNP cord-302530-pp6bl941 780 4 and and CC cord-302530-pp6bl941 780 5 infectivity infectivity NN cord-302530-pp6bl941 780 6 of of IN cord-302530-pp6bl941 780 7 human human JJ cord-302530-pp6bl941 780 8 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 780 9 virus virus NN cord-302530-pp6bl941 780 10 type type NN cord-302530-pp6bl941 780 11 1 1 CD cord-302530-pp6bl941 780 12 are be VBP cord-302530-pp6bl941 780 13 modified modify VBN cord-302530-pp6bl941 780 14 by by IN cord-302530-pp6bl941 780 15 the the DT cord-302530-pp6bl941 780 16 fluidity fluidity NN cord-302530-pp6bl941 780 17 of of IN cord-302530-pp6bl941 780 18 the the DT cord-302530-pp6bl941 780 19 plasma plasma NN cord-302530-pp6bl941 780 20 membrane membrane NN cord-302530-pp6bl941 780 21 for for IN cord-302530-pp6bl941 780 22 multiple multiple JJ cord-302530-pp6bl941 780 23 - - HYPH cord-302530-pp6bl941 780 24 site site NN cord-302530-pp6bl941 780 25 binding bind VBG cord-302530-pp6bl941 780 26 Viral viral JJ cord-302530-pp6bl941 780 27 membrane membrane NN cord-302530-pp6bl941 780 28 fusion fusion NN cord-302530-pp6bl941 780 29 . . . cord-302530-pp6bl941 781 1 Virology Virology NNP cord-302530-pp6bl941 781 2 479 479 CD cord-302530-pp6bl941 781 3 - - SYM cord-302530-pp6bl941 781 4 480 480 CD cord-302530-pp6bl941 781 5 Cryo Cryo NNP cord-302530-pp6bl941 781 6 - - HYPH cord-302530-pp6bl941 781 7 EM EM NNP cord-302530-pp6bl941 781 8 structures structure NNS cord-302530-pp6bl941 781 9 of of IN cord-302530-pp6bl941 781 10 eastern eastern JJ cord-302530-pp6bl941 781 11 equine equine JJ cord-302530-pp6bl941 781 12 encephalitis encephalitis NNP cord-302530-pp6bl941 781 13 virus virus NN cord-302530-pp6bl941 781 14 reveal reveal VBP cord-302530-pp6bl941 781 15 mechanisms mechanism NNS cord-302530-pp6bl941 781 16 of of IN cord-302530-pp6bl941 781 17 virus virus NN cord-302530-pp6bl941 781 18 disassembly disassembly NN cord-302530-pp6bl941 781 19 and and CC cord-302530-pp6bl941 781 20 antibody antibody NN cord-302530-pp6bl941 781 21 neutralization neutralization NN cord-302530-pp6bl941 781 22 Binding binding NN cord-302530-pp6bl941 781 23 of of IN cord-302530-pp6bl941 781 24 western western JJ cord-302530-pp6bl941 781 25 equine equine JJ cord-302530-pp6bl941 781 26 encephalomyelitis encephalomyelitis NN cord-302530-pp6bl941 781 27 virus virus NN cord-302530-pp6bl941 781 28 to to TO cord-302530-pp6bl941 781 29 brush brush VB cord-302530-pp6bl941 781 30 border border NN cord-302530-pp6bl941 781 31 fragments fragment NNS cord-302530-pp6bl941 781 32 isolated isolate VBN cord-302530-pp6bl941 781 33 from from IN cord-302530-pp6bl941 781 34 mesenteronal mesenteronal JJ cord-302530-pp6bl941 781 35 epithelial epithelial JJ cord-302530-pp6bl941 781 36 cells cell NNS cord-302530-pp6bl941 781 37 of of IN cord-302530-pp6bl941 781 38 mosquitoes mosquito NNS cord-302530-pp6bl941 782 1 Effects effect NNS cord-302530-pp6bl941 782 2 of of IN cord-302530-pp6bl941 782 3 simian simian JJ cord-302530-pp6bl941 782 4 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 782 5 virus virus NN cord-302530-pp6bl941 782 6 on on IN cord-302530-pp6bl941 782 7 the the DT cord-302530-pp6bl941 782 8 circadian circadian NN cord-302530-pp6bl941 782 9 rhythms rhythm NNS cord-302530-pp6bl941 782 10 of of IN cord-302530-pp6bl941 782 11 body body NN cord-302530-pp6bl941 782 12 temperature temperature NN cord-302530-pp6bl941 782 13 and and CC cord-302530-pp6bl941 782 14 gross gross JJ cord-302530-pp6bl941 782 15 locomotor locomotor NN cord-302530-pp6bl941 782 16 activity activity NN cord-302530-pp6bl941 782 17 Thermodynamic thermodynamic JJ cord-302530-pp6bl941 782 18 analysis analysis NN cord-302530-pp6bl941 782 19 of of IN cord-302530-pp6bl941 782 20 the the DT cord-302530-pp6bl941 782 21 binding binding NN cord-302530-pp6bl941 782 22 of of IN cord-302530-pp6bl941 782 23 component component NN cord-302530-pp6bl941 782 24 enzymes enzyme NNS cord-302530-pp6bl941 782 25 in in IN cord-302530-pp6bl941 782 26 the the DT cord-302530-pp6bl941 782 27 assembly assembly NN cord-302530-pp6bl941 782 28 of of IN cord-302530-pp6bl941 782 29 the the DT cord-302530-pp6bl941 782 30 pyruvate pyruvate NN cord-302530-pp6bl941 782 31 dehydrogenase dehydrogenase NN cord-302530-pp6bl941 782 32 multienzyme multienzyme NNS cord-302530-pp6bl941 782 33 complex complex NN cord-302530-pp6bl941 782 34 of of IN cord-302530-pp6bl941 782 35 Bacillus Bacillus NNP cord-302530-pp6bl941 782 36 stearothermophilus stearothermophilus NN cord-302530-pp6bl941 782 37 Avian avian JJ cord-302530-pp6bl941 782 38 virulence virulence NN cord-302530-pp6bl941 782 39 and and CC cord-302530-pp6bl941 782 40 thermostable thermostable JJ cord-302530-pp6bl941 782 41 replication replication NN cord-302530-pp6bl941 782 42 of of IN cord-302530-pp6bl941 782 43 the the DT cord-302530-pp6bl941 782 44 North north JJ cord-302530-pp6bl941 782 45 American american JJ cord-302530-pp6bl941 782 46 strain strain NN cord-302530-pp6bl941 782 47 of of IN cord-302530-pp6bl941 782 48 west west NN cord-302530-pp6bl941 782 49 Nile Nile NNP cord-302530-pp6bl941 782 50 virus virus NN cord-302530-pp6bl941 783 1 The the DT cord-302530-pp6bl941 783 2 molecular molecular JJ cord-302530-pp6bl941 783 3 basis basis NN cord-302530-pp6bl941 783 4 of of IN cord-302530-pp6bl941 783 5 HIV HIV NNP cord-302530-pp6bl941 783 6 entry entry NN cord-302530-pp6bl941 783 7 Cooperation Cooperation NNP cord-302530-pp6bl941 783 8 of of IN cord-302530-pp6bl941 783 9 multiple multiple JJ cord-302530-pp6bl941 783 10 CCR5 CCR5 NNP cord-302530-pp6bl941 783 11 coreceptors coreceptor NNS cord-302530-pp6bl941 783 12 is be VBZ cord-302530-pp6bl941 783 13 required require VBN cord-302530-pp6bl941 783 14 for for IN cord-302530-pp6bl941 783 15 infections infection NNS cord-302530-pp6bl941 783 16 by by IN cord-302530-pp6bl941 783 17 human human JJ cord-302530-pp6bl941 783 18 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 783 19 virus virus NN cord-302530-pp6bl941 783 20 type type NN cord-302530-pp6bl941 783 21 1 1 CD cord-302530-pp6bl941 783 22 Testing test VBG cord-302530-pp6bl941 783 23 new new JJ cord-302530-pp6bl941 783 24 hypotheses hypothesis NNS cord-302530-pp6bl941 783 25 regarding regard VBG cord-302530-pp6bl941 783 26 ebolavirus ebolavirus NN cord-302530-pp6bl941 783 27 reservoirs reservoir NNS cord-302530-pp6bl941 783 28 . . . cord-302530-pp6bl941 784 1 Viruses virus NNS cord-302530-pp6bl941 784 2 8 8 CD cord-302530-pp6bl941 784 3 Quaternary quaternary JJ cord-302530-pp6bl941 784 4 contact contact NN cord-302530-pp6bl941 784 5 in in IN cord-302530-pp6bl941 784 6 the the DT cord-302530-pp6bl941 784 7 initial initial JJ cord-302530-pp6bl941 784 8 interaction interaction NN cord-302530-pp6bl941 784 9 of of IN cord-302530-pp6bl941 784 10 CD4 CD4 NNP cord-302530-pp6bl941 784 11 with with IN cord-302530-pp6bl941 784 12 the the DT cord-302530-pp6bl941 784 13 HIV-1 HIV-1 NNP cord-302530-pp6bl941 784 14 envelope envelope NN cord-302530-pp6bl941 784 15 trimer trimer NN cord-302530-pp6bl941 784 16 Temperature temperature NN cord-302530-pp6bl941 784 17 increase increase NN cord-302530-pp6bl941 784 18 enhances enhance VBZ cord-302530-pp6bl941 784 19 Aedes Aedes NNP cord-302530-pp6bl941 784 20 albopictus albopictus NN cord-302530-pp6bl941 784 21 competence competence NN cord-302530-pp6bl941 784 22 to to TO cord-302530-pp6bl941 784 23 transmit transmit VB cord-302530-pp6bl941 784 24 Dengue Dengue NNP cord-302530-pp6bl941 784 25 virus virus NN cord-302530-pp6bl941 784 26 Molecular molecular JJ cord-302530-pp6bl941 784 27 basis basis NN cord-302530-pp6bl941 784 28 of of IN cord-302530-pp6bl941 784 29 binding bind VBG cord-302530-pp6bl941 784 30 between between IN cord-302530-pp6bl941 784 31 novel novel JJ cord-302530-pp6bl941 784 32 human human JJ cord-302530-pp6bl941 784 33 coronavirus coronavirus NN cord-302530-pp6bl941 784 34 MERS MERS NNP cord-302530-pp6bl941 784 35 - - HYPH cord-302530-pp6bl941 784 36 COV COV NNP cord-302530-pp6bl941 784 37 and and CC cord-302530-pp6bl941 784 38 its -PRON- PRP$ cord-302530-pp6bl941 784 39 cellular cellular JJ cord-302530-pp6bl941 784 40 receptor receptor NN cord-302530-pp6bl941 784 41 CD26 CD26 NNP cord-302530-pp6bl941 784 42 Polyvalent Polyvalent NNP cord-302530-pp6bl941 784 43 interactions interaction NNS cord-302530-pp6bl941 784 44 in in IN cord-302530-pp6bl941 784 45 biological biological JJ cord-302530-pp6bl941 784 46 systems system NNS cord-302530-pp6bl941 784 47 : : : cord-302530-pp6bl941 784 48 implications implication NNS cord-302530-pp6bl941 784 49 for for IN cord-302530-pp6bl941 784 50 design design NN cord-302530-pp6bl941 784 51 and and CC cord-302530-pp6bl941 784 52 use use NN cord-302530-pp6bl941 784 53 of of IN cord-302530-pp6bl941 784 54 multivalent multivalent JJ cord-302530-pp6bl941 784 55 ligands ligand NNS cord-302530-pp6bl941 784 56 and and CC cord-302530-pp6bl941 784 57 inhibitors inhibitor NNS cord-302530-pp6bl941 784 58 Thermodynamic thermodynamic JJ cord-302530-pp6bl941 784 59 and and CC cord-302530-pp6bl941 784 60 kinetic kinetic JJ cord-302530-pp6bl941 784 61 analysis analysis NN cord-302530-pp6bl941 784 62 of of IN cord-302530-pp6bl941 784 63 sCD4 sCD4 NNP cord-302530-pp6bl941 784 64 binding bind VBG cord-302530-pp6bl941 784 65 to to IN cord-302530-pp6bl941 784 66 HIV-1 HIV-1 NNP cord-302530-pp6bl941 784 67 virions virion NNS cord-302530-pp6bl941 784 68 and and CC cord-302530-pp6bl941 784 69 of of IN cord-302530-pp6bl941 784 70 gp120 gp120 DT cord-302530-pp6bl941 784 71 dissociation dissociation NN cord-302530-pp6bl941 784 72 Structure Structure NNP cord-302530-pp6bl941 784 73 of of IN cord-302530-pp6bl941 784 74 west west NNP cord-302530-pp6bl941 784 75 Nile Nile NNP cord-302530-pp6bl941 784 76 virus virus NN cord-302530-pp6bl941 784 77 Environmental environmental JJ cord-302530-pp6bl941 784 78 effects effect NNS cord-302530-pp6bl941 784 79 on on IN cord-302530-pp6bl941 784 80 vector vector NN cord-302530-pp6bl941 784 81 competence competence NN cord-302530-pp6bl941 784 82 and and CC cord-302530-pp6bl941 784 83 virogenesis virogenesis NN cord-302530-pp6bl941 784 84 of of IN cord-302530-pp6bl941 784 85 bluetongue bluetongue NN cord-302530-pp6bl941 784 86 virus virus NN cord-302530-pp6bl941 784 87 in in IN cord-302530-pp6bl941 784 88 Culicoides Culicoides NNP cord-302530-pp6bl941 784 89 interpreting interpret VBG cord-302530-pp6bl941 784 90 laboratory laboratory NN cord-302530-pp6bl941 784 91 data datum NNS cord-302530-pp6bl941 784 92 in in IN cord-302530-pp6bl941 784 93 a a DT cord-302530-pp6bl941 784 94 field field NN cord-302530-pp6bl941 784 95 context context NN cord-302530-pp6bl941 784 96 Energetics energetic NNS cord-302530-pp6bl941 784 97 of of IN cord-302530-pp6bl941 784 98 the the DT cord-302530-pp6bl941 784 99 HIV HIV NNP cord-302530-pp6bl941 784 100 gp120-CD4 gp120-CD4 NNP cord-302530-pp6bl941 784 101 binding binding NN cord-302530-pp6bl941 784 102 reaction reaction NN cord-302530-pp6bl941 784 103 Interactions interaction NNS cord-302530-pp6bl941 784 104 between between IN cord-302530-pp6bl941 784 105 the the DT cord-302530-pp6bl941 784 106 inner inner JJ cord-302530-pp6bl941 784 107 and and CC cord-302530-pp6bl941 784 108 outer outer JJ cord-302530-pp6bl941 784 109 capsids capsid NNS cord-302530-pp6bl941 784 110 of of IN cord-302530-pp6bl941 784 111 bluetongue bluetongue NN cord-302530-pp6bl941 784 112 virus virus NN cord-302530-pp6bl941 784 113 Replication replication NN cord-302530-pp6bl941 784 114 and and CC cord-302530-pp6bl941 784 115 transcription transcription NN cord-302530-pp6bl941 784 116 activities activity NNS cord-302530-pp6bl941 784 117 of of IN cord-302530-pp6bl941 784 118 ribonucleoprotein ribonucleoprotein NN cord-302530-pp6bl941 784 119 complexes complex NNS cord-302530-pp6bl941 784 120 reconstituted reconstitute VBN cord-302530-pp6bl941 784 121 from from IN cord-302530-pp6bl941 784 122 avian avian JJ cord-302530-pp6bl941 784 123 H5N1 H5N1 NNP cord-302530-pp6bl941 784 124 , , , cord-302530-pp6bl941 784 125 H1N1pdm09 H1N1pdm09 NNP cord-302530-pp6bl941 784 126 and and CC cord-302530-pp6bl941 784 127 H3N2 H3N2 NNP cord-302530-pp6bl941 785 1 influenza influenza NN cord-302530-pp6bl941 785 2 A a DT cord-302530-pp6bl941 785 3 viruses virus NNS cord-302530-pp6bl941 786 1 Temperature temperature NN cord-302530-pp6bl941 786 2 effects effect NNS cord-302530-pp6bl941 786 3 on on IN cord-302530-pp6bl941 786 4 virion virion NN cord-302530-pp6bl941 786 5 volume volume NN cord-302530-pp6bl941 786 6 and and CC cord-302530-pp6bl941 786 7 genome genome NN cord-302530-pp6bl941 786 8 length length NN cord-302530-pp6bl941 786 9 in in IN cord-302530-pp6bl941 786 10 dsDNA dsdna JJ cord-302530-pp6bl941 786 11 viruses virus NNS cord-302530-pp6bl941 787 1 Bat bat NN cord-302530-pp6bl941 787 2 flight flight NN cord-302530-pp6bl941 787 3 and and CC cord-302530-pp6bl941 787 4 zoonotic zoonotic JJ cord-302530-pp6bl941 787 5 viruses virus NNS cord-302530-pp6bl941 787 6 Investigating investigate VBG cord-302530-pp6bl941 787 7 the the DT cord-302530-pp6bl941 787 8 zoonotic zoonotic JJ cord-302530-pp6bl941 787 9 origin origin NN cord-302530-pp6bl941 787 10 of of IN cord-302530-pp6bl941 787 11 the the DT cord-302530-pp6bl941 787 12 west west JJ cord-302530-pp6bl941 787 13 African african JJ cord-302530-pp6bl941 787 14 Ebola Ebola NNP cord-302530-pp6bl941 787 15 epidemic epidemic NN cord-302530-pp6bl941 787 16 Simian simian JJ cord-302530-pp6bl941 787 17 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 787 18 virus virus NN cord-302530-pp6bl941 787 19 infection infection NN cord-302530-pp6bl941 787 20 of of IN cord-302530-pp6bl941 787 21 Chimpanzees Chimpanzees NNPS cord-302530-pp6bl941 787 22 Establishment Establishment NNP cord-302530-pp6bl941 787 23 of of IN cord-302530-pp6bl941 787 24 reference reference NN cord-302530-pp6bl941 787 25 CD4 CD4 NNP cord-302530-pp6bl941 787 26 + + CC cord-302530-pp6bl941 787 27 t t NN cord-302530-pp6bl941 787 28 cell cell NN cord-302530-pp6bl941 787 29 values value NNS cord-302530-pp6bl941 787 30 for for IN cord-302530-pp6bl941 787 31 adult adult JJ cord-302530-pp6bl941 787 32 Indian indian JJ cord-302530-pp6bl941 787 33 population population NN cord-302530-pp6bl941 787 34 Receptor receptor NN cord-302530-pp6bl941 787 35 binding bind VBG cord-302530-pp6bl941 787 36 by by IN cord-302530-pp6bl941 787 37 a a DT cord-302530-pp6bl941 787 38 ferret ferret JJ cord-302530-pp6bl941 787 39 - - HYPH cord-302530-pp6bl941 787 40 transmissible transmissible JJ cord-302530-pp6bl941 787 41 H5 H5 NNP cord-302530-pp6bl941 787 42 avian avian JJ cord-302530-pp6bl941 787 43 influenza influenza NN cord-302530-pp6bl941 787 44 New new JJ cord-302530-pp6bl941 787 45 insights insight NNS cord-302530-pp6bl941 787 46 into into IN cord-302530-pp6bl941 787 47 the the DT cord-302530-pp6bl941 787 48 Hendra Hendra NNP cord-302530-pp6bl941 787 49 virus virus NN cord-302530-pp6bl941 787 50 attachment attachment NN cord-302530-pp6bl941 787 51 and and CC cord-302530-pp6bl941 787 52 entry entry NN cord-302530-pp6bl941 787 53 process process NN cord-302530-pp6bl941 787 54 from from IN cord-302530-pp6bl941 787 55 structures structure NNS cord-302530-pp6bl941 787 56 of of IN cord-302530-pp6bl941 787 57 the the DT cord-302530-pp6bl941 787 58 virus virus NN cord-302530-pp6bl941 787 59 G g NN cord-302530-pp6bl941 787 60 glycoprotein glycoprotein NN cord-302530-pp6bl941 787 61 and and CC cord-302530-pp6bl941 787 62 its -PRON- PRP$ cord-302530-pp6bl941 787 63 complex complex NN cord-302530-pp6bl941 787 64 with with IN cord-302530-pp6bl941 787 65 ephrin ephrin NN cord-302530-pp6bl941 787 66 - - HYPH cord-302530-pp6bl941 787 67 B2 B2 NNP cord-302530-pp6bl941 787 68 Stoichiometry Stoichiometry NNP cord-302530-pp6bl941 787 69 of of IN cord-302530-pp6bl941 787 70 envelope envelope NN cord-302530-pp6bl941 787 71 glycoprotein glycoprotein NN cord-302530-pp6bl941 787 72 trimers trimer NNS cord-302530-pp6bl941 787 73 in in IN cord-302530-pp6bl941 787 74 the the DT cord-302530-pp6bl941 787 75 entry entry NN cord-302530-pp6bl941 787 76 of of IN cord-302530-pp6bl941 787 77 human human JJ cord-302530-pp6bl941 787 78 immunodeficiency immunodeficiency NN cord-302530-pp6bl941 787 79 virus virus NN cord-302530-pp6bl941 787 80 type type NN cord-302530-pp6bl941 787 81 1 1 CD cord-302530-pp6bl941 787 82 TIM-1 TIM-1 NNP cord-302530-pp6bl941 787 83 acts act VBZ cord-302530-pp6bl941 787 84 a a DT cord-302530-pp6bl941 787 85 dual dual JJ cord-302530-pp6bl941 787 86 - - HYPH cord-302530-pp6bl941 787 87 attachment attachment NN cord-302530-pp6bl941 787 88 receptor receptor NN cord-302530-pp6bl941 787 89 for for IN cord-302530-pp6bl941 787 90 Ebolavirus Ebolavirus NNP cord-302530-pp6bl941 787 91 by by IN cord-302530-pp6bl941 787 92 interacting interact VBG cord-302530-pp6bl941 787 93 directly directly RB cord-302530-pp6bl941 787 94 with with IN cord-302530-pp6bl941 787 95 viral viral JJ cord-302530-pp6bl941 787 96 GP gp NN cord-302530-pp6bl941 787 97 and and CC cord-302530-pp6bl941 787 98 the the DT cord-302530-pp6bl941 787 99 PS PS NNP cord-302530-pp6bl941 787 100 on on IN cord-302530-pp6bl941 787 101 the the DT cord-302530-pp6bl941 787 102 viral viral JJ cord-302530-pp6bl941 787 103 envelope envelope NN cord-302530-pp6bl941 787 104 Bluetongue Bluetongue NNP cord-302530-pp6bl941 787 105 virus virus NN cord-302530-pp6bl941 787 106 coat coat NN cord-302530-pp6bl941 787 107 protein protein NN cord-302530-pp6bl941 787 108 VP2 VP2 NNP cord-302530-pp6bl941 787 109 contains contain VBZ cord-302530-pp6bl941 787 110 sialic sialic JJ cord-302530-pp6bl941 787 111 acid acid NN cord-302530-pp6bl941 787 112 - - HYPH cord-302530-pp6bl941 787 113 binding bind VBG cord-302530-pp6bl941 787 114 domains domain NNS cord-302530-pp6bl941 787 115 , , , cord-302530-pp6bl941 787 116 and and CC cord-302530-pp6bl941 787 117 VP5 VP5 NNS cord-302530-pp6bl941 787 118 resembles resemble VBZ cord-302530-pp6bl941 787 119 enveloped envelop VBN cord-302530-pp6bl941 787 120 virus virus NN cord-302530-pp6bl941 787 121 fusion fusion NN cord-302530-pp6bl941 787 122 proteins protein NNS cord-302530-pp6bl941 788 1 I -PRON- PRP cord-302530-pp6bl941 788 2 thank thank VBP cord-302530-pp6bl941 788 3 the the DT cord-302530-pp6bl941 788 4 anonymous anonymous JJ cord-302530-pp6bl941 788 5 reviewer reviewer NN cord-302530-pp6bl941 788 6 who who WP cord-302530-pp6bl941 788 7 helped help VBD cord-302530-pp6bl941 788 8 me -PRON- PRP cord-302530-pp6bl941 788 9 with with IN cord-302530-pp6bl941 788 10 the the DT cord-302530-pp6bl941 788 11 HIV HIV NNP cord-302530-pp6bl941 788 12 binding bind VBG cord-302530-pp6bl941 788 13 data datum NNS cord-302530-pp6bl941 788 14 and and CC cord-302530-pp6bl941 788 15 greatly greatly RB cord-302530-pp6bl941 788 16 improved improve VBD cord-302530-pp6bl941 788 17 this this DT cord-302530-pp6bl941 788 18 manuscript manuscript NN cord-302530-pp6bl941 788 19 . . . cord-302530-pp6bl941 789 1 I -PRON- PRP cord-302530-pp6bl941 789 2 wrote write VBD cord-302530-pp6bl941 789 3 the the DT cord-302530-pp6bl941 789 4 whole whole NN cord-302530-pp6bl941 789 5 of of IN cord-302530-pp6bl941 789 6 this this DT cord-302530-pp6bl941 789 7 paper paper NN cord-302530-pp6bl941 789 8 , , , cord-302530-pp6bl941 789 9 did do VBD cord-302530-pp6bl941 789 10 all all PDT cord-302530-pp6bl941 789 11 the the DT cord-302530-pp6bl941 789 12 work work NN cord-302530-pp6bl941 789 13 and and CC cord-302530-pp6bl941 789 14 developed develop VBD cord-302530-pp6bl941 789 15 all all PDT cord-302530-pp6bl941 789 16 the the DT cord-302530-pp6bl941 789 17 ideas idea NNS cord-302530-pp6bl941 789 18 . . . cord-302530-pp6bl941 790 1 I -PRON- PRP cord-302530-pp6bl941 790 2 have have VBP cord-302530-pp6bl941 790 3 done do VBN cord-302530-pp6bl941 790 4 this this DT cord-302530-pp6bl941 790 5 work work NN cord-302530-pp6bl941 790 6 in in IN cord-302530-pp6bl941 790 7 my -PRON- PRP$ cord-302530-pp6bl941 790 8 spare spare JJ cord-302530-pp6bl941 790 9 time time NN cord-302530-pp6bl941 790 10 at at IN cord-302530-pp6bl941 790 11 home home NN cord-302530-pp6bl941 790 12 with with IN cord-302530-pp6bl941 790 13 no no DT cord-302530-pp6bl941 790 14 funding funding NN cord-302530-pp6bl941 790 15 . . . cord-302530-pp6bl941 791 1 I -PRON- PRP cord-302530-pp6bl941 791 2 greatly greatly RB cord-302530-pp6bl941 791 3 enjoy enjoy VBP cord-302530-pp6bl941 791 4 doing do VBG cord-302530-pp6bl941 791 5 this this DT cord-302530-pp6bl941 791 6 sort sort NN cord-302530-pp6bl941 791 7 of of IN cord-302530-pp6bl941 791 8 paper paper NN cord-302530-pp6bl941 791 9 . . . cord-302530-pp6bl941 792 1 The the DT cord-302530-pp6bl941 792 2 views view NNS cord-302530-pp6bl941 792 3 expressed express VBN cord-302530-pp6bl941 792 4 in in IN cord-302530-pp6bl941 792 5 this this DT cord-302530-pp6bl941 792 6 paper paper NN cord-302530-pp6bl941 792 7 are be VBP cord-302530-pp6bl941 792 8 those those DT cord-302530-pp6bl941 792 9 of of IN cord-302530-pp6bl941 792 10 the the DT cord-302530-pp6bl941 792 11 author author NN cord-302530-pp6bl941 792 12 and and CC cord-302530-pp6bl941 792 13 not not RB cord-302530-pp6bl941 792 14 necessarily necessarily RB cord-302530-pp6bl941 792 15 those those DT cord-302530-pp6bl941 792 16 of of IN cord-302530-pp6bl941 792 17 any any DT cord-302530-pp6bl941 792 18 organisations organisation NNS cord-302530-pp6bl941 792 19 . . . cord-302530-pp6bl941 793 1 None none NN cord-302530-pp6bl941 793 2 declared declare VBD cord-302530-pp6bl941 793 3 . . .