id	sid	tid	token	lemma	pos
cord-302082-aaokc182	1	1	key	key	NN
cord-302082-aaokc182	1	2	:	:	:
cord-302082-aaokc182	1	3	cord-302082-aaokc182	cord-302082-aaokc182	NNP
cord-302082-aaokc182	1	4	authors	author	NNS
cord-302082-aaokc182	1	5	:	:	:
cord-302082-aaokc182	1	6	Stanberry	Stanberry	NNP
cord-302082-aaokc182	1	7	,	,	,
cord-302082-aaokc182	1	8	Lawrence	Lawrence	NNP
cord-302082-aaokc182	1	9	R.	R.	NNP
cord-302082-aaokc182	1	10	;	;	:
cord-302082-aaokc182	1	11	Strugnell	Strugnell	NNP
cord-302082-aaokc182	1	12	,	,	,
cord-302082-aaokc182	1	13	Richard	Richard	NNP
cord-302082-aaokc182	1	14	title	title	NN
cord-302082-aaokc182	1	15	:	:	:
cord-302082-aaokc182	1	16	Vaccines	vaccine	NNS
cord-302082-aaokc182	1	17	of	of	IN
cord-302082-aaokc182	1	18	the	the	DT
cord-302082-aaokc182	1	19	future	future	JJ
cord-302082-aaokc182	1	20	date	date	NN
cord-302082-aaokc182	1	21	:	:	:
cord-302082-aaokc182	1	22	2011	2011	CD
cord-302082-aaokc182	1	23	-	-	SYM
cord-302082-aaokc182	1	24	08	08	CD
cord-302082-aaokc182	1	25	-	-	HYPH
cord-302082-aaokc182	1	26	31	31	CD
cord-302082-aaokc182	1	27	journal	journal	NN
cord-302082-aaokc182	1	28	:	:	:
cord-302082-aaokc182	1	29	Perspectives	perspective	NNS
cord-302082-aaokc182	1	30	in	in	IN
cord-302082-aaokc182	1	31	Vaccinology	Vaccinology	NNP
cord-302082-aaokc182	1	32	DOI	DOI	NNP
cord-302082-aaokc182	1	33	:	:	:
cord-302082-aaokc182	1	34	10.1016/	10.1016/	CD
cord-302082-aaokc182	2	1	j.pervac.2011.05.006	j.pervac.2011.05.006	NFP
cord-302082-aaokc182	2	2	sha	sha	NNP
cord-302082-aaokc182	2	3	:	:	:
cord-302082-aaokc182	2	4	e60b4fcf80aaad1476cae520377853544ce74a0f	e60b4fcf80aaad1476cae520377853544ce74a0f	NNP
cord-302082-aaokc182	2	5	doc_id	doc_id	NNPS
cord-302082-aaokc182	2	6	:	:	:
cord-302082-aaokc182	2	7	302082	302082	CD
cord-302082-aaokc182	2	8	cord_uid	cord_uid	NNS
cord-302082-aaokc182	2	9	:	:	:
cord-302082-aaokc182	3	1	aaokc182	aaokc182	NNP
cord-302082-aaokc182	3	2	nan	nan	NNP
cord-302082-aaokc182	4	1	The	the	DT
cord-302082-aaokc182	4	2	advances	advance	NNS
cord-302082-aaokc182	4	3	made	make	VBN
cord-302082-aaokc182	4	4	in	in	IN
cord-302082-aaokc182	4	5	vaccine	vaccine	NN
cord-302082-aaokc182	4	6	technology	technology	NN
cord-302082-aaokc182	4	7	since	since	IN
cord-302082-aaokc182	4	8	Edward	Edward	NNP
cord-302082-aaokc182	4	9	Jenner	Jenner	NNP
cord-302082-aaokc182	4	10	vaccinated	vaccinate	VBD
cord-302082-aaokc182	4	11	the	the	DT
cord-302082-aaokc182	4	12	young	young	JJ
cord-302082-aaokc182	4	13	James	James	NNP
cord-302082-aaokc182	4	14	Phipps	Phipps	NNP
cord-302082-aaokc182	4	15	against	against	IN
cord-302082-aaokc182	4	16	smallpox	smallpox	NN
cord-302082-aaokc182	4	17	have	have	VBP
cord-302082-aaokc182	4	18	had	have	VBN
cord-302082-aaokc182	4	19	a	a	DT
cord-302082-aaokc182	4	20	spectacular	spectacular	JJ
cord-302082-aaokc182	4	21	impact	impact	NN
cord-302082-aaokc182	4	22	on	on	IN
cord-302082-aaokc182	4	23	human	human	JJ
cord-302082-aaokc182	4	24	health	health	NN
cord-302082-aaokc182	4	25	over	over	IN
cord-302082-aaokc182	4	26	the	the	DT
cord-302082-aaokc182	4	27	last	last	JJ
cord-302082-aaokc182	4	28	two	two	CD
cord-302082-aaokc182	4	29	centuries	century	NNS
cord-302082-aaokc182	4	30	(	(	-LRB-
cord-302082-aaokc182	4	31	see	see	VB
cord-302082-aaokc182	4	32	Chapter	chapter	NN
cord-302082-aaokc182	4	33	1	1	CD
cord-302082-aaokc182	4	34	e	e	NN
cord-302082-aaokc182	4	35	Vaccine	vaccine	NN
cord-302082-aaokc182	4	36	evolution	evolution	NN
cord-302082-aaokc182	4	37	)	)	-RRB-
cord-302082-aaokc182	4	38	.	.	.
cord-302082-aaokc182	5	1	Vaccines	vaccine	NNS
cord-302082-aaokc182	5	2	have	have	VBP
cord-302082-aaokc182	5	3	been	be	VBN
cord-302082-aaokc182	5	4	fundamental	fundamental	JJ
cord-302082-aaokc182	5	5	in	in	IN
cord-302082-aaokc182	5	6	the	the	DT
cord-302082-aaokc182	5	7	control	control	NN
cord-302082-aaokc182	5	8	and	and	CC
cord-302082-aaokc182	5	9	elimination	elimination	NN
cord-302082-aaokc182	5	10	of	of	IN
cord-302082-aaokc182	5	11	many	many	JJ
cord-302082-aaokc182	5	12	debilitating	debilitating	JJ
cord-302082-aaokc182	5	13	and	and	CC
cord-302082-aaokc182	5	14	lethal	lethal	JJ
cord-302082-aaokc182	5	15	diseases	disease	NNS
cord-302082-aaokc182	5	16	,	,	,
cord-302082-aaokc182	5	17	and	and	CC
cord-302082-aaokc182	5	18	more	more	JJR
cord-302082-aaokc182	5	19	diseases	disease	NNS
cord-302082-aaokc182	5	20	are	be	VBP
cord-302082-aaokc182	5	21	currently	currently	RB
cord-302082-aaokc182	5	22	targeted	target	VBN
cord-302082-aaokc182	5	23	for	for	IN
cord-302082-aaokc182	5	24	eradication	eradication	NN
cord-302082-aaokc182	5	25	by	by	IN
cord-302082-aaokc182	5	26	vaccination	vaccination	NN
cord-302082-aaokc182	5	27	.	.	.
cord-302082-aaokc182	6	1	Recent	recent	JJ
cord-302082-aaokc182	6	2	major	major	JJ
cord-302082-aaokc182	6	3	breakthroughs	breakthrough	NNS
cord-302082-aaokc182	6	4	in	in	IN
cord-302082-aaokc182	6	5	immunology	immunology	NN
cord-302082-aaokc182	6	6	,	,	,
cord-302082-aaokc182	6	7	molecular	molecular	JJ
cord-302082-aaokc182	6	8	biology	biology	NN
cord-302082-aaokc182	6	9	,	,	,
cord-302082-aaokc182	6	10	genomics	genomic	NNS
cord-302082-aaokc182	6	11	,	,	,
cord-302082-aaokc182	6	12	proteomics	proteomic	NNS
cord-302082-aaokc182	6	13	,	,	,
cord-302082-aaokc182	6	14	biochemistry	biochemistry	NN
cord-302082-aaokc182	6	15	and	and	CC
cord-302082-aaokc182	6	16	computing	computing	NN
cord-302082-aaokc182	6	17	sciences	science	NNS
cord-302082-aaokc182	6	18	have	have	VBP
cord-302082-aaokc182	6	19	driven	drive	VBN
cord-302082-aaokc182	6	20	vaccine	vaccine	NN
cord-302082-aaokc182	6	21	technology	technology	NN
cord-302082-aaokc182	6	22	forward	forward	RB
cord-302082-aaokc182	6	23	,	,	,
cord-302082-aaokc182	6	24	and	and	CC
cord-302082-aaokc182	6	25	will	will	MD
cord-302082-aaokc182	6	26	continue	continue	VB
cord-302082-aaokc182	6	27	to	to	TO
cord-302082-aaokc182	6	28	do	do	VB
cord-302082-aaokc182	6	29	so	so	RB
cord-302082-aaokc182	6	30	.	.	.
cord-302082-aaokc182	7	1	Many	many	JJ
cord-302082-aaokc182	7	2	challenges	challenge	NNS
cord-302082-aaokc182	7	3	remain	remain	VBP
cord-302082-aaokc182	7	4	,	,	,
cord-302082-aaokc182	7	5	however	however	RB
cord-302082-aaokc182	7	6	,	,	,
cord-302082-aaokc182	7	7	including	include	VBG
cord-302082-aaokc182	7	8	persistent	persistent	JJ
cord-302082-aaokc182	7	9	or	or	CC
cord-302082-aaokc182	7	10	latent	latent	JJ
cord-302082-aaokc182	7	11	infections	infection	NNS
cord-302082-aaokc182	7	12	,	,	,
cord-302082-aaokc182	7	13	pathogens	pathogen	NNS
cord-302082-aaokc182	7	14	with	with	IN
cord-302082-aaokc182	7	15	complex	complex	JJ
cord-302082-aaokc182	7	16	life	life	NN
cord-302082-aaokc182	7	17	cycles	cycle	NNS
cord-302082-aaokc182	7	18	,	,	,
cord-302082-aaokc182	7	19	antigenic	antigenic	JJ
cord-302082-aaokc182	7	20	drift	drift	NN
cord-302082-aaokc182	7	21	and	and	CC
cord-302082-aaokc182	7	22	shift	shift	VB
cord-302082-aaokc182	7	23	in	in	IN
cord-302082-aaokc182	7	24	pathogens	pathogen	NNS
cord-302082-aaokc182	7	25	subject	subject	JJ
cord-302082-aaokc182	7	26	to	to	IN
cord-302082-aaokc182	7	27	selective	selective	JJ
cord-302082-aaokc182	7	28	pressures	pressure	NNS
cord-302082-aaokc182	7	29	,	,	,
cord-302082-aaokc182	7	30	challenging	challenge	VBG
cord-302082-aaokc182	7	31	populations	population	NNS
cord-302082-aaokc182	7	32	and	and	CC
cord-302082-aaokc182	7	33	emerging	emerge	VBG
cord-302082-aaokc182	7	34	infections	infection	NNS
cord-302082-aaokc182	7	35	.	.	.
cord-302082-aaokc182	8	1	To	to	TO
cord-302082-aaokc182	8	2	address	address	VB
cord-302082-aaokc182	8	3	these	these	DT
cord-302082-aaokc182	8	4	challenges	challenge	NNS
cord-302082-aaokc182	8	5	researchers	researcher	NNS
cord-302082-aaokc182	8	6	are	be	VBP
cord-302082-aaokc182	8	7	exploring	explore	VBG
cord-302082-aaokc182	8	8	many	many	JJ
cord-302082-aaokc182	8	9	avenues	avenue	NNS
cord-302082-aaokc182	8	10	:	:	:
cord-302082-aaokc182	8	11	novel	novel	NN
cord-302082-aaokc182	8	12	adjuvants	adjuvant	NNS
cord-302082-aaokc182	8	13	are	be	VBP
cord-302082-aaokc182	8	14	being	be	VBG
cord-302082-aaokc182	8	15	developed	develop	VBN
cord-302082-aaokc182	8	16	that	that	WDT
cord-302082-aaokc182	8	17	enhance	enhance	VB
cord-302082-aaokc182	8	18	the	the	DT
cord-302082-aaokc182	8	19	immune	immune	JJ
cord-302082-aaokc182	8	20	response	response	NN
cord-302082-aaokc182	8	21	elicited	elicit	VBN
cord-302082-aaokc182	8	22	by	by	IN
cord-302082-aaokc182	8	23	a	a	DT
cord-302082-aaokc182	8	24	vaccine	vaccine	NN
cord-302082-aaokc182	8	25	while	while	IN
cord-302082-aaokc182	8	26	maintaining	maintain	VBG
cord-302082-aaokc182	8	27	high	high	JJ
cord-302082-aaokc182	8	28	levels	level	NNS
cord-302082-aaokc182	8	29	of	of	IN
cord-302082-aaokc182	8	30	tolerability	tolerability	NN
cord-302082-aaokc182	8	31	;	;	:
cord-302082-aaokc182	8	32	methods	method	NNS
cord-302082-aaokc182	8	33	of	of	IN
cord-302082-aaokc182	8	34	protective	protective	JJ
cord-302082-aaokc182	8	35	antigen	antigen	NN
cord-302082-aaokc182	8	36	identification	identification	NN
cord-302082-aaokc182	8	37	are	be	VBP
cord-302082-aaokc182	8	38	iterated	iterate	VBN
cord-302082-aaokc182	8	39	with	with	IN
cord-302082-aaokc182	8	40	every	every	DT
cord-302082-aaokc182	8	41	success	success	NN
cord-302082-aaokc182	8	42	;	;	:
cord-302082-aaokc182	8	43	vaccine	vaccine	NN
cord-302082-aaokc182	8	44	storage	storage	NN
cord-302082-aaokc182	8	45	and	and	CC
cord-302082-aaokc182	8	46	transport	transport	NN
cord-302082-aaokc182	8	47	systems	system	NNS
cord-302082-aaokc182	8	48	are	be	VBP
cord-302082-aaokc182	8	49	improving	improve	VBG
cord-302082-aaokc182	8	50	(	(	-LRB-
cord-302082-aaokc182	8	51	including	include	VBG
cord-302082-aaokc182	8	52	optimising	optimise	VBG
cord-302082-aaokc182	8	53	the	the	DT
cord-302082-aaokc182	8	54	cold	cold	JJ
cord-302082-aaokc182	8	55	chain	chain	NN
cord-302082-aaokc182	8	56	and	and	CC
cord-302082-aaokc182	8	57	developing	develop	VBG
cord-302082-aaokc182	8	58	temperature	temperature	NN
cord-302082-aaokc182	8	59	-	-	HYPH
cord-302082-aaokc182	8	60	stable	stable	JJ
cord-302082-aaokc182	8	61	vaccines	vaccine	NNS
cord-302082-aaokc182	8	62	)	)	-RRB-
cord-302082-aaokc182	8	63	;	;	:
cord-302082-aaokc182	8	64	and	and	CC
cord-302082-aaokc182	8	65	new	new	JJ
cord-302082-aaokc182	8	66	and	and	CC
cord-302082-aaokc182	8	67	potentially	potentially	RB
cord-302082-aaokc182	8	68	more	more	RBR
cord-302082-aaokc182	8	69	convenient	convenient	JJ
cord-302082-aaokc182	8	70	methods	method	NNS
cord-302082-aaokc182	8	71	of	of	IN
cord-302082-aaokc182	8	72	vaccine	vaccine	NN
cord-302082-aaokc182	8	73	administration	administration	NN
cord-302082-aaokc182	8	74	are	be	VBP
cord-302082-aaokc182	8	75	being	be	VBG
cord-302082-aaokc182	8	76	pursued	pursue	VBN
cord-302082-aaokc182	8	77	.	.	.
cord-302082-aaokc182	9	1	High	high	JJ
cord-302082-aaokc182	9	2	priority	priority	NN
cord-302082-aaokc182	9	3	targets	target	NNS
cord-302082-aaokc182	9	4	include	include	VBP
cord-302082-aaokc182	9	5	life	life	NN
cord-302082-aaokc182	9	6	-	-	HYPH
cord-302082-aaokc182	9	7	threatening	threaten	VBG
cord-302082-aaokc182	9	8	diseases	disease	NNS
cord-302082-aaokc182	9	9	,	,	,
cord-302082-aaokc182	9	10	such	such	JJ
cord-302082-aaokc182	9	11	as	as	IN
cord-302082-aaokc182	9	12	malaria	malaria	NN
cord-302082-aaokc182	9	13	,	,	,
cord-302082-aaokc182	9	14	tuberculosis	tuberculosis	NN
cord-302082-aaokc182	9	15	(	(	-LRB-
cord-302082-aaokc182	9	16	TB	TB	NNP
cord-302082-aaokc182	9	17	)	)	-RRB-
cord-302082-aaokc182	9	18	and	and	CC
cord-302082-aaokc182	9	19	human	human	JJ
cord-302082-aaokc182	9	20	immunodeficiency	immunodeficiency	NN
cord-302082-aaokc182	9	21	virus	virus	NN
cord-302082-aaokc182	9	22	(	(	-LRB-
cord-302082-aaokc182	9	23	HIV	HIV	NNP
cord-302082-aaokc182	9	24	)	)	-RRB-
cord-302082-aaokc182	9	25	,	,	,
cord-302082-aaokc182	9	26	as	as	RB
cord-302082-aaokc182	9	27	well	well	RB
cord-302082-aaokc182	9	28	as	as	IN
cord-302082-aaokc182	9	29	problematic	problematic	JJ
cord-302082-aaokc182	9	30	infections	infection	NNS
cord-302082-aaokc182	9	31	caused	cause	VBN
cord-302082-aaokc182	9	32	by	by	IN
cord-302082-aaokc182	9	33	ubiquitous	ubiquitous	JJ
cord-302082-aaokc182	9	34	agents	agent	NNS
cord-302082-aaokc182	9	35	,	,	,
cord-302082-aaokc182	9	36	such	such	JJ
cord-302082-aaokc182	9	37	as	as	IN
cord-302082-aaokc182	9	38	respiratory	respiratory	JJ
cord-302082-aaokc182	9	39	syncytial	syncytial	JJ
cord-302082-aaokc182	9	40	virus	virus	NN
cord-302082-aaokc182	9	41	(	(	-LRB-
cord-302082-aaokc182	9	42	RSV	RSV	NNP
cord-302082-aaokc182	9	43	)	)	-RRB-
cord-302082-aaokc182	9	44	,	,	,
cord-302082-aaokc182	9	45	cytomegalovirus	cytomegalovirus	NNP
cord-302082-aaokc182	9	46	(	(	-LRB-
cord-302082-aaokc182	9	47	CMV	CMV	NNP
cord-302082-aaokc182	9	48	)	)	-RRB-
cord-302082-aaokc182	9	49	and	and	CC
cord-302082-aaokc182	9	50	Staphylococcus	Staphylococcus	NNP
cord-302082-aaokc182	9	51	aureus	aureus	NN
cord-302082-aaokc182	9	52	.	.	.
cord-302082-aaokc182	10	1	Non	non	JJ
cord-302082-aaokc182	10	2	-	-	JJ
cord-302082-aaokc182	10	3	traditional	traditional	JJ
cord-302082-aaokc182	10	4	vaccines	vaccine	NNS
cord-302082-aaokc182	10	5	are	be	VBP
cord-302082-aaokc182	10	6	also	also	RB
cord-302082-aaokc182	10	7	likely	likely	JJ
cord-302082-aaokc182	10	8	to	to	TO
cord-302082-aaokc182	10	9	become	become	VB
cord-302082-aaokc182	10	10	available	available	JJ
cord-302082-aaokc182	10	11	for	for	IN
cord-302082-aaokc182	10	12	the	the	DT
cord-302082-aaokc182	10	13	management	management	NN
cord-302082-aaokc182	10	14	of	of	IN
cord-302082-aaokc182	10	15	addiction	addiction	NN
cord-302082-aaokc182	10	16	,	,	,
cord-302082-aaokc182	10	17	and	and	CC
cord-302082-aaokc182	10	18	the	the	DT
cord-302082-aaokc182	10	19	prevention	prevention	NN
cord-302082-aaokc182	10	20	,	,	,
cord-302082-aaokc182	10	21	treatment	treatment	NN
cord-302082-aaokc182	10	22	and	and	CC
cord-302082-aaokc182	10	23	cure	cure	NN
cord-302082-aaokc182	10	24	of	of	IN
cord-302082-aaokc182	10	25	malignancies	malignancy	NNS
cord-302082-aaokc182	10	26	.	.	.
cord-302082-aaokc182	11	1	This	this	DT
cord-302082-aaokc182	11	2	chapter	chapter	NN
cord-302082-aaokc182	11	3	is	be	VBZ
cord-302082-aaokc182	11	4	not	not	RB
cord-302082-aaokc182	11	5	meant	mean	VBN
cord-302082-aaokc182	11	6	as	as	IN
cord-302082-aaokc182	11	7	a	a	DT
cord-302082-aaokc182	11	8	compendium	compendium	NN
cord-302082-aaokc182	11	9	of	of	IN
cord-302082-aaokc182	11	10	all	all	DT
cord-302082-aaokc182	11	11	new	new	JJ
cord-302082-aaokc182	11	12	-	-	HYPH
cord-302082-aaokc182	11	13	generation	generation	NN
cord-302082-aaokc182	11	14	vaccines	vaccine	NNS
cord-302082-aaokc182	11	15	,	,	,
cord-302082-aaokc182	11	16	but	but	CC
cord-302082-aaokc182	11	17	rather	rather	RB
cord-302082-aaokc182	11	18	as	as	IN
cord-302082-aaokc182	11	19	an	an	DT
cord-302082-aaokc182	11	20	outline	outline	NN
cord-302082-aaokc182	11	21	of	of	IN
cord-302082-aaokc182	11	22	the	the	DT
cord-302082-aaokc182	11	23	modern	modern	JJ
cord-302082-aaokc182	11	24	principles	principle	NNS
cord-302082-aaokc182	11	25	that	that	WDT
cord-302082-aaokc182	11	26	will	will	MD
cord-302082-aaokc182	11	27	likely	likely	RB
cord-302082-aaokc182	11	28	facilitate	facilitate	VB
cord-302082-aaokc182	11	29	the	the	DT
cord-302082-aaokc182	11	30	development	development	NN
cord-302082-aaokc182	11	31	of	of	IN
cord-302082-aaokc182	11	32	future	future	JJ
cord-302082-aaokc182	11	33	vaccines	vaccine	NNS
cord-302082-aaokc182	11	34	.	.	.
cord-302082-aaokc182	12	1	As	as	IN
cord-302082-aaokc182	12	2	shown	show	VBN
cord-302082-aaokc182	12	3	in	in	IN
cord-302082-aaokc182	12	4	Figure	Figure	NNP
cord-302082-aaokc182	12	5	6	6	CD
cord-302082-aaokc182	12	6	.1	.1	NNS
cord-302082-aaokc182	12	7	,	,	,
cord-302082-aaokc182	12	8	there	there	EX
cord-302082-aaokc182	12	9	are	be	VBP
cord-302082-aaokc182	12	10	several	several	JJ
cord-302082-aaokc182	12	11	key	key	JJ
cord-302082-aaokc182	12	12	elements	element	NNS
cord-302082-aaokc182	12	13	that	that	WDT
cord-302082-aaokc182	12	14	are	be	VBP
cord-302082-aaokc182	12	15	likely	likely	JJ
cord-302082-aaokc182	12	16	to	to	TO
cord-302082-aaokc182	12	17	be	be	VB
cord-302082-aaokc182	12	18	152	152	CD
cord-302082-aaokc182	12	19	UNDERSTANDING	understanding	NN
cord-302082-aaokc182	13	1	MODERN	modern	JJ
cord-302082-aaokc182	13	2	VACCINES	vaccine	NNS
cord-302082-aaokc182	14	1	the	the	DT
cord-302082-aaokc182	14	2	foundation	foundation	NN
cord-302082-aaokc182	14	3	for	for	IN
cord-302082-aaokc182	14	4	the	the	DT
cord-302082-aaokc182	14	5	development	development	NN
cord-302082-aaokc182	14	6	of	of	IN
cord-302082-aaokc182	14	7	future	future	JJ
cord-302082-aaokc182	14	8	vaccines	vaccine	NNS
cord-302082-aaokc182	14	9	.	.	.
cord-302082-aaokc182	15	1	This	this	DT
cord-302082-aaokc182	15	2	chapter	chapter	NN
cord-302082-aaokc182	15	3	will	will	MD
cord-302082-aaokc182	15	4	illustrate	illustrate	VB
cord-302082-aaokc182	15	5	these	these	DT
cord-302082-aaokc182	15	6	elements	element	NNS
cord-302082-aaokc182	15	7	and	and	CC
cord-302082-aaokc182	15	8	provide	provide	VB
cord-302082-aaokc182	15	9	examples	example	NNS
cord-302082-aaokc182	15	10	that	that	WDT
cord-302082-aaokc182	15	11	show	show	VBP
cord-302082-aaokc182	15	12	promise	promise	NN
cord-302082-aaokc182	15	13	.	.	.
cord-302082-aaokc182	16	1	Since	since	IN
cord-302082-aaokc182	16	2	the	the	DT
cord-302082-aaokc182	16	3	first	first	JJ
cord-302082-aaokc182	16	4	use	use	NN
cord-302082-aaokc182	16	5	of	of	IN
cord-302082-aaokc182	16	6	an	an	DT
cord-302082-aaokc182	16	7	adjuvant	adjuvant	NN
cord-302082-aaokc182	16	8	in	in	IN
cord-302082-aaokc182	16	9	a	a	DT
cord-302082-aaokc182	16	10	human	human	JJ
cord-302082-aaokc182	16	11	vaccine	vaccine	NN
cord-302082-aaokc182	16	12	over	over	IN
cord-302082-aaokc182	16	13	80	80	CD
cord-302082-aaokc182	16	14	years	year	NNS
cord-302082-aaokc182	16	15	ago	ago	RB
cord-302082-aaokc182	16	16	,	,	,
cord-302082-aaokc182	16	17	adjuvant	adjuvant	JJ
cord-302082-aaokc182	16	18	technology	technology	NN
cord-302082-aaokc182	16	19	has	have	VBZ
cord-302082-aaokc182	16	20	improved	improve	VBN
cord-302082-aaokc182	16	21	significantly	significantly	RB
cord-302082-aaokc182	16	22	with	with	IN
cord-302082-aaokc182	16	23	respect	respect	NN
cord-302082-aaokc182	16	24	to	to	IN
cord-302082-aaokc182	16	25	improving	improve	VBG
cord-302082-aaokc182	16	26	vaccine	vaccine	NN
cord-302082-aaokc182	16	27	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	16	28	and	and	CC
cord-302082-aaokc182	16	29	efficacy	efficacy	NN
cord-302082-aaokc182	16	30	.	.	.
cord-302082-aaokc182	17	1	Over	over	IN
cord-302082-aaokc182	17	2	The	the	DT
cord-302082-aaokc182	17	3	advances	advance	NNS
cord-302082-aaokc182	17	4	in	in	IN
cord-302082-aaokc182	17	5	adjuvant	adjuvant	NN
cord-302082-aaokc182	17	6	design	design	NN
cord-302082-aaokc182	17	7	have	have	VBP
cord-302082-aaokc182	17	8	been	be	VBN
cord-302082-aaokc182	17	9	driven	drive	VBN
cord-302082-aaokc182	17	10	by	by	IN
cord-302082-aaokc182	17	11	parallel	parallel	JJ
cord-302082-aaokc182	17	12	advances	advance	NNS
cord-302082-aaokc182	17	13	in	in	IN
cord-302082-aaokc182	17	14	vaccine	vaccine	NN
cord-302082-aaokc182	17	15	technology	technology	NN
cord-302082-aaokc182	17	16	as	as	IN
cord-302082-aaokc182	17	17	many	many	JJ
cord-302082-aaokc182	17	18	modern	modern	JJ
cord-302082-aaokc182	17	19	vaccines	vaccine	NNS
cord-302082-aaokc182	17	20	consist	consist	VBP
cord-302082-aaokc182	17	21	of	of	IN
cord-302082-aaokc182	17	22	highly	highly	RB
cord-302082-aaokc182	17	23	purified	purify	VBN
cord-302082-aaokc182	17	24	antigens	antigen	NNS
cord-302082-aaokc182	17	25	e	e	NN
cord-302082-aaokc182	17	26	with	with	IN
cord-302082-aaokc182	17	27	low	low	JJ
cord-302082-aaokc182	17	28	non	non	JJ
cord-302082-aaokc182	17	29	-	-	JJ
cord-302082-aaokc182	17	30	specific	specific	JJ
cord-302082-aaokc182	17	31	reactogenicity	reactogenicity	NN
cord-302082-aaokc182	17	32	which	which	WDT
cord-302082-aaokc182	17	33	require	require	VBP
cord-302082-aaokc182	17	34	combination	combination	NN
cord-302082-aaokc182	17	35	with	with	IN
cord-302082-aaokc182	17	36	adjuvants	adjuvant	NNS
cord-302082-aaokc182	17	37	to	to	TO
cord-302082-aaokc182	17	38	enhance	enhance	VB
cord-302082-aaokc182	17	39	the	the	DT
cord-302082-aaokc182	17	40	immune	immune	JJ
cord-302082-aaokc182	17	41	response	response	NN
cord-302082-aaokc182	17	42	.	.	.
cord-302082-aaokc182	18	1	Future	future	JJ
cord-302082-aaokc182	18	2	developments	development	NNS
cord-302082-aaokc182	18	3	in	in	IN
cord-302082-aaokc182	18	4	adjuvant	adjuvant	NN
cord-302082-aaokc182	18	5	technology	technology	NN
cord-302082-aaokc182	18	6	are	be	VBP
cord-302082-aaokc182	18	7	expected	expect	VBN
cord-302082-aaokc182	18	8	to	to	TO
cord-302082-aaokc182	18	9	provide	provide	VB
cord-302082-aaokc182	18	10	stronger	strong	JJR
cord-302082-aaokc182	18	11	immune	immune	JJ
cord-302082-aaokc182	18	12	priming	priming	NN
cord-302082-aaokc182	18	13	,	,	,
cord-302082-aaokc182	18	14	enhance	enhance	VB
cord-302082-aaokc182	18	15	immune	immune	JJ
cord-302082-aaokc182	18	16	responses	response	NNS
cord-302082-aaokc182	18	17	in	in	IN
cord-302082-aaokc182	18	18	specific	specific	JJ
cord-302082-aaokc182	18	19	populations	population	NNS
cord-302082-aaokc182	18	20	,	,	,
cord-302082-aaokc182	18	21	and	and	CC
cord-302082-aaokc182	18	22	lead	lead	VB
cord-302082-aaokc182	18	23	to	to	IN
cord-302082-aaokc182	18	24	antigen	antigen	NN
cord-302082-aaokc182	18	25	sparing	sparing	NN
cord-302082-aaokc182	18	26	.	.	.
cord-302082-aaokc182	19	1	Adjuvants	adjuvant	NNS
cord-302082-aaokc182	19	2	to	to	IN
cord-302082-aaokc182	19	3	date	date	NN
cord-302082-aaokc182	19	4	have	have	VBP
cord-302082-aaokc182	19	5	demonstrated	demonstrate	VBN
cord-302082-aaokc182	19	6	an	an	DT
cord-302082-aaokc182	19	7	ability	ability	NN
cord-302082-aaokc182	19	8	 	 	_SP
cord-302082-aaokc182	19	9	New	new	JJ
cord-302082-aaokc182	19	10	adjuvants	adjuvant	NNS
cord-302082-aaokc182	19	11	must	must	MD
cord-302082-aaokc182	19	12	aim	aim	VB
cord-302082-aaokc182	19	13	to	to	TO
cord-302082-aaokc182	19	14	drive	drive	VB
cord-302082-aaokc182	19	15	the	the	DT
cord-302082-aaokc182	19	16	immune	immune	JJ
cord-302082-aaokc182	19	17	response	response	NN
cord-302082-aaokc182	19	18	that	that	WDT
cord-302082-aaokc182	19	19	is	be	VBZ
cord-302082-aaokc182	19	20	associated	associate	VBN
cord-302082-aaokc182	19	21	with	with	IN
cord-302082-aaokc182	19	22	lifelong	lifelong	JJ
cord-302082-aaokc182	19	23	protection	protection	NN
cord-302082-aaokc182	19	24	.	.	.
cord-302082-aaokc182	20	1	New	new	JJ
cord-302082-aaokc182	20	2	adjuvants	adjuvant	NNS
cord-302082-aaokc182	20	3	and	and	CC
cord-302082-aaokc182	20	4	adjuvant	adjuvant	JJ
cord-302082-aaokc182	20	5	combinations	combination	NNS
cord-302082-aaokc182	20	6	will	will	MD
cord-302082-aaokc182	20	7	play	play	VB
cord-302082-aaokc182	20	8	many	many	JJ
cord-302082-aaokc182	20	9	roles	role	NNS
cord-302082-aaokc182	20	10	in	in	IN
cord-302082-aaokc182	20	11	future	future	JJ
cord-302082-aaokc182	20	12	vaccines	vaccine	NNS
cord-302082-aaokc182	20	13	as	as	IN
cord-302082-aaokc182	20	14	illustrated	illustrate	VBN
cord-302082-aaokc182	20	15	in	in	IN
cord-302082-aaokc182	20	16	Figure	Figure	NNP
cord-302082-aaokc182	20	17	6	6	CD
cord-302082-aaokc182	20	18	.2	.2	CD
cord-302082-aaokc182	20	19	.	.	.
cord-302082-aaokc182	21	1	Adjuvants	adjuvant	NNS
cord-302082-aaokc182	21	2	will	will	MD
cord-302082-aaokc182	21	3	need	need	VB
cord-302082-aaokc182	21	4	to	to	TO
cord-302082-aaokc182	21	5	be	be	VB
cord-302082-aaokc182	21	6	individually	individually	RB
cord-302082-aaokc182	21	7	selected	select	VBN
cord-302082-aaokc182	21	8	for	for	IN
cord-302082-aaokc182	21	9	specific	specific	JJ
cord-302082-aaokc182	21	10	vaccine	vaccine	NN
cord-302082-aaokc182	21	11	targets	target	NNS
cord-302082-aaokc182	21	12	in	in	IN
cord-302082-aaokc182	21	13	order	order	NN
cord-302082-aaokc182	21	14	to	to	TO
cord-302082-aaokc182	21	15	achieve	achieve	VB
cord-302082-aaokc182	21	16	the	the	DT
cord-302082-aaokc182	21	17	desired	desire	VBN
cord-302082-aaokc182	21	18	goal	goal	NN
cord-302082-aaokc182	21	19	(	(	-LRB-
cord-302082-aaokc182	21	20	ie	ie	RB
cord-302082-aaokc182	21	21	enhanced	enhance	VBN
cord-302082-aaokc182	21	22	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	21	23	,	,	,
cord-302082-aaokc182	21	24	induction	induction	NN
cord-302082-aaokc182	21	25	of	of	IN
cord-302082-aaokc182	21	26	specific	specific	JJ
cord-302082-aaokc182	21	27	immune	immune	JJ
cord-302082-aaokc182	21	28	profile	profile	NN
cord-302082-aaokc182	21	29	etc	etc	FW
cord-302082-aaokc182	21	30	)	)	-RRB-
cord-302082-aaokc182	21	31	.	.	.
cord-302082-aaokc182	22	1	To	to	TO
cord-302082-aaokc182	22	2	deliver	deliver	VB
cord-302082-aaokc182	22	3	this	this	DT
cord-302082-aaokc182	22	4	aim	aim	NN
cord-302082-aaokc182	22	5	,	,	,
cord-302082-aaokc182	22	6	some	some	DT
cord-302082-aaokc182	22	7	adjuvants	adjuvant	NNS
cord-302082-aaokc182	22	8	will	will	MD
cord-302082-aaokc182	22	9	be	be	VB
cord-302082-aaokc182	22	10	mixed	mix	VBN
cord-302082-aaokc182	22	11	with	with	IN
cord-302082-aaokc182	22	12	free	free	JJ
cord-302082-aaokc182	22	13	antigens	antigen	NNS
cord-302082-aaokc182	22	14	,	,	,
cord-302082-aaokc182	22	15	while	while	IN
cord-302082-aaokc182	22	16	others	other	NNS
cord-302082-aaokc182	22	17	will	will	MD
cord-302082-aaokc182	22	18	need	need	VB
cord-302082-aaokc182	22	19	to	to	TO
cord-302082-aaokc182	22	20	be	be	VB
cord-302082-aaokc182	22	21	covalently	covalently	RB
cord-302082-aaokc182	22	22	linked	link	VBN
cord-302082-aaokc182	22	23	to	to	IN
cord-302082-aaokc182	22	24	the	the	DT
cord-302082-aaokc182	22	25	antigenic	antigenic	JJ
cord-302082-aaokc182	22	26	moiety	moiety	NN
cord-302082-aaokc182	22	27	as	as	IN
cord-302082-aaokc182	22	28	part	part	NN
cord-302082-aaokc182	22	29	of	of	IN
cord-302082-aaokc182	22	30	a	a	DT
cord-302082-aaokc182	22	31	complex	complex	JJ
cord-302082-aaokc182	22	32	molecule	molecule	NN
cord-302082-aaokc182	22	33	.	.	.
cord-302082-aaokc182	23	1	Some	some	DT
cord-302082-aaokc182	23	2	examples	example	NNS
cord-302082-aaokc182	23	3	of	of	IN
cord-302082-aaokc182	23	4	new	new	JJ
cord-302082-aaokc182	23	5	adjuvants	adjuvant	NNS
cord-302082-aaokc182	23	6	that	that	WDT
cord-302082-aaokc182	23	7	have	have	VBP
cord-302082-aaokc182	23	8	been	be	VBN
cord-302082-aaokc182	23	9	evaluated	evaluate	VBN
cord-302082-aaokc182	23	10	in	in	IN
cord-302082-aaokc182	23	11	humans	human	NNS
cord-302082-aaokc182	23	12	or	or	CC
cord-302082-aaokc182	23	13	that	that	WDT
cord-302082-aaokc182	23	14	are	be	VBP
cord-302082-aaokc182	23	15	in	in	IN
cord-302082-aaokc182	23	16	clinical	clinical	JJ
cord-302082-aaokc182	23	17	trials	trial	NNS
cord-302082-aaokc182	23	18	are	be	VBP
cord-302082-aaokc182	23	19	listed	list	VBN
cord-302082-aaokc182	23	20	in	in	IN
cord-302082-aaokc182	23	21	Table	Table	NNP
cord-302082-aaokc182	23	22	6	6	CD
cord-302082-aaokc182	23	23	.1	.1	.
cord-302082-aaokc182	23	24	(	(	-LRB-
cord-302082-aaokc182	23	25	also	also	RB
cord-302082-aaokc182	23	26	see	see	VB
cord-302082-aaokc182	23	27	Chapter	chapter	NN
cord-302082-aaokc182	23	28	4	4	CD
cord-302082-aaokc182	23	29	e	e	NN
cord-302082-aaokc182	23	30	Vaccine	vaccine	NN
cord-302082-aaokc182	23	31	adjuvants	adjuvant	NNS
cord-302082-aaokc182	23	32	)	)	-RRB-
cord-302082-aaokc182	23	33	.	.	.
cord-302082-aaokc182	24	1	Modern	modern	JJ
cord-302082-aaokc182	24	2	approaches	approach	NNS
cord-302082-aaokc182	24	3	to	to	IN
cord-302082-aaokc182	24	4	antigen	antigen	NN
cord-302082-aaokc182	24	5	design	design	NN
cord-302082-aaokc182	24	6	tend	tend	VBP
cord-302082-aaokc182	24	7	to	to	TO
cord-302082-aaokc182	24	8	eschew	eschew	VB
cord-302082-aaokc182	24	9	classical	classical	JJ
cord-302082-aaokc182	24	10	trial	trial	NN
cord-302082-aaokc182	24	11	and	and	CC
cord-302082-aaokc182	24	12	error	error	NN
cord-302082-aaokc182	24	13	techniques	technique	NNS
cord-302082-aaokc182	24	14	in	in	IN
cord-302082-aaokc182	24	15	favour	favour	NN
cord-302082-aaokc182	24	16	of	of	IN
cord-302082-aaokc182	24	17	identifying	identify	VBG
cord-302082-aaokc182	24	18	the	the	DT
cord-302082-aaokc182	24	19	type	type	NN
cord-302082-aaokc182	24	20	of	of	IN
cord-302082-aaokc182	24	21	pathogenic	pathogenic	JJ
cord-302082-aaokc182	24	22	structures	structure	NNS
cord-302082-aaokc182	24	23	(	(	-LRB-
cord-302082-aaokc182	24	24	ie	ie	NNP
cord-302082-aaokc182	24	25	antigens	antigens	NNP
cord-302082-aaokc182	24	26	)	)	-RRB-
cord-302082-aaokc182	24	27	that	that	WDT
cord-302082-aaokc182	24	28	are	be	VBP
cord-302082-aaokc182	24	29	most	most	RBS
cord-302082-aaokc182	24	30	likely	likely	JJ
cord-302082-aaokc182	24	31	to	to	TO
cord-302082-aaokc182	24	32	be	be	VB
cord-302082-aaokc182	24	33	important	important	JJ
cord-302082-aaokc182	24	34	immunogens	immunogen	NNS
cord-302082-aaokc182	24	35	based	base	VBN
cord-302082-aaokc182	24	36	on	on	IN
cord-302082-aaokc182	24	37	their	-PRON-	PRP$
cord-302082-aaokc182	24	38	structural	structural	JJ
cord-302082-aaokc182	24	39	signature	signature	NN
cord-302082-aaokc182	24	40	or	or	CC
cord-302082-aaokc182	24	41	physical	physical	JJ
cord-302082-aaokc182	24	42	location	location	NN
cord-302082-aaokc182	24	43	within	within	IN
cord-302082-aaokc182	24	44	the	the	DT
cord-302082-aaokc182	24	45	pathogen	pathogen	NN
cord-302082-aaokc182	24	46	(	(	-LRB-
cord-302082-aaokc182	24	47	Table	table	NN
cord-302082-aaokc182	24	48	6	6	CD
cord-302082-aaokc182	24	49	.2	.2	CD
cord-302082-aaokc182	24	50	)	)	-RRB-
cord-302082-aaokc182	24	51	(	(	-LRB-
cord-302082-aaokc182	24	52	see	see	VB
cord-302082-aaokc182	24	53	Chapter	chapter	NN
cord-302082-aaokc182	24	54	3	3	CD
cord-302082-aaokc182	24	55	e	e	NN
cord-302082-aaokc182	24	56	Vaccine	vaccine	NN
cord-302082-aaokc182	24	57	antigens	antigen	NNS
cord-302082-aaokc182	24	58	)	)	-RRB-
cord-302082-aaokc182	24	59	.	.	.
cord-302082-aaokc182	25	1	The	the	DT
cord-302082-aaokc182	25	2	T	t	NN
cord-302082-aaokc182	25	3	or	or	CC
cord-302082-aaokc182	25	4	B	b	NN
cord-302082-aaokc182	25	5	cell	cell	NN
cord-302082-aaokc182	25	6	immune	immune	JJ
cord-302082-aaokc182	25	7	responses	response	NNS
cord-302082-aaokc182	25	8	to	to	IN
cord-302082-aaokc182	25	9	an	an	DT
cord-302082-aaokc182	25	10	antigen	antigen	NN
cord-302082-aaokc182	25	11	are	be	VBP
cord-302082-aaokc182	25	12	targeted	target	VBN
cord-302082-aaokc182	25	13	to	to	IN
cord-302082-aaokc182	25	14	precise	precise	JJ
cord-302082-aaokc182	25	15	regions	region	NNS
cord-302082-aaokc182	25	16	of	of	IN
cord-302082-aaokc182	25	17	the	the	DT
cord-302082-aaokc182	25	18	antigen	antigen	NN
cord-302082-aaokc182	25	19	(	(	-LRB-
cord-302082-aaokc182	25	20	ie	ie	FW
cord-302082-aaokc182	25	21	epitopes	epitopes	NNP
cord-302082-aaokc182	25	22	e	e	NNP
cord-302082-aaokc182	26	1	either	either	CC
cord-302082-aaokc182	26	2	linear	linear	JJ
cord-302082-aaokc182	26	3	or	or	CC
cord-302082-aaokc182	26	4	three	three	CD
cord-302082-aaokc182	26	5	-	-	HYPH
cord-302082-aaokc182	26	6	dimensional	dimensional	JJ
cord-302082-aaokc182	26	7	conformational	conformational	JJ
cord-302082-aaokc182	26	8	structures	structure	NNS
cord-302082-aaokc182	26	9	;	;	:
cord-302082-aaokc182	26	10	in	in	IN
cord-302082-aaokc182	26	11	the	the	DT
cord-302082-aaokc182	26	12	case	case	NN
cord-302082-aaokc182	26	13	of	of	IN
cord-302082-aaokc182	26	14	protein	protein	NN
cord-302082-aaokc182	26	15	antigens	antigen	NNS
cord-302082-aaokc182	26	16	these	these	DT
cord-302082-aaokc182	26	17	are	be	VBP
cord-302082-aaokc182	26	18	specific	specific	JJ
cord-302082-aaokc182	26	19	peptide	peptide	JJ
cord-302082-aaokc182	26	20	epitopes	epitope	NNS
cord-302082-aaokc182	26	21	)	)	-RRB-
cord-302082-aaokc182	26	22	.	.	.
cord-302082-aaokc182	27	1	Historically	historically	RB
cord-302082-aaokc182	27	2	,	,	,
cord-302082-aaokc182	27	3	simple	simple	JJ
cord-302082-aaokc182	27	4	,	,	,
cord-302082-aaokc182	27	5	linear	linear	JJ
cord-302082-aaokc182	27	6	,	,	,
cord-302082-aaokc182	27	7	synthetic	synthetic	JJ
cord-302082-aaokc182	27	8	peptide	peptide	NN
cord-302082-aaokc182	27	9	epitope	epitope	NN
cord-302082-aaokc182	27	10	vaccines	vaccine	NNS
cord-302082-aaokc182	27	11	have	have	VBP
cord-302082-aaokc182	27	12	been	be	VBN
cord-302082-aaokc182	27	13	poorly	poorly	RB
cord-302082-aaokc182	27	14	immunogenic	immunogenic	JJ
cord-302082-aaokc182	27	15	because	because	IN
cord-302082-aaokc182	27	16	they	-PRON-	PRP
cord-302082-aaokc182	27	17	lack	lack	VBP
cord-302082-aaokc182	27	18	a	a	DT
cord-302082-aaokc182	27	19	specific	specific	JJ
cord-302082-aaokc182	27	20	conformation	conformation	NN
cord-302082-aaokc182	27	21	and	and	CC
cord-302082-aaokc182	27	22	are	be	VBP
cord-302082-aaokc182	27	23	easily	easily	RB
cord-302082-aaokc182	27	24	degraded	degrade	VBN
cord-302082-aaokc182	27	25	by	by	IN
cord-302082-aaokc182	27	26	a	a	DT
cord-302082-aaokc182	27	27	variety	variety	NN
cord-302082-aaokc182	27	28	of	of	IN
cord-302082-aaokc182	27	29	extracellular	extracellular	JJ
cord-302082-aaokc182	27	30	and	and	CC
cord-302082-aaokc182	27	31	cell	cell	NN
cord-302082-aaokc182	27	32	-	-	HYPH
cord-302082-aaokc182	27	33	surface	surface	NN
cord-302082-aaokc182	27	34	proteases	protease	NNS
cord-302082-aaokc182	27	35	that	that	WDT
cord-302082-aaokc182	27	36	serve	serve	VBP
cord-302082-aaokc182	27	37	to	to	TO
cord-302082-aaokc182	27	38	limit	limit	VB
cord-302082-aaokc182	27	39	epitope	epitope	NN
cord-302082-aaokc182	27	40	presentation	presentation	NN
cord-302082-aaokc182	27	41	to	to	IN
cord-302082-aaokc182	27	42	T	t	NN
cord-302082-aaokc182	27	43	cells	cell	NNS
cord-302082-aaokc182	28	1	and/or	and/or	CC
cord-302082-aaokc182	28	2	result	result	VB
cord-302082-aaokc182	28	3	in	in	IN
cord-302082-aaokc182	28	4	destruction	destruction	NN
cord-302082-aaokc182	28	5	of	of	IN
cord-302082-aaokc182	28	6	the	the	DT
cord-302082-aaokc182	28	7	B	b	NN
cord-302082-aaokc182	28	8	-	-	HYPH
cord-302082-aaokc182	28	9	cell	cell	NN
cord-302082-aaokc182	28	10	epitope	epitope	NN
cord-302082-aaokc182	28	11	.	.	.
cord-302082-aaokc182	29	1	Peptide	peptide	NN
cord-302082-aaokc182	29	2	vaccines	vaccine	NNS
cord-302082-aaokc182	29	3	need	need	VBP
cord-302082-aaokc182	29	4	to	to	IN
cord-302082-aaokc182	29	5	Union	Union	NNP
cord-302082-aaokc182	29	6	.	.	.
cord-302082-aaokc182	30	1	Every	every	DT
cord-302082-aaokc182	30	2	effort	effort	NN
cord-302082-aaokc182	30	3	has	have	VBZ
cord-302082-aaokc182	30	4	been	be	VBN
cord-302082-aaokc182	30	5	made	make	VBN
cord-302082-aaokc182	30	6	to	to	TO
cord-302082-aaokc182	30	7	verify	verify	VB
cord-302082-aaokc182	30	8	the	the	DT
cord-302082-aaokc182	30	9	information	information	NN
cord-302082-aaokc182	30	10	in	in	IN
cord-302082-aaokc182	30	11	the	the	DT
cord-302082-aaokc182	30	12	above	above	JJ
cord-302082-aaokc182	30	13	table	table	NN
cord-302082-aaokc182	30	14	.	.	.
cord-302082-aaokc182	31	1	The	the	DT
cord-302082-aaokc182	31	2	information	information	NN
cord-302082-aaokc182	31	3	included	include	VBD
cord-302082-aaokc182	31	4	is	be	VBZ
cord-302082-aaokc182	31	5	not	not	RB
cord-302082-aaokc182	31	6	meant	mean	VBN
cord-302082-aaokc182	31	7	to	to	TO
cord-302082-aaokc182	31	8	be	be	VB
cord-302082-aaokc182	31	9	exhaustive	exhaustive	JJ
cord-302082-aaokc182	31	10	but	but	CC
cord-302082-aaokc182	31	11	is	be	VBZ
cord-302082-aaokc182	31	12	intended	intend	VBN
cord-302082-aaokc182	31	13	to	to	TO
cord-302082-aaokc182	31	14	provide	provide	VB
cord-302082-aaokc182	31	15	an	an	DT
cord-302082-aaokc182	31	16	overview	overview	NN
cord-302082-aaokc182	31	17	of	of	IN
cord-302082-aaokc182	31	18	the	the	DT
cord-302082-aaokc182	31	19	subject	subject	JJ
cord-302082-aaokc182	31	20	matter	matter	NN
cord-302082-aaokc182	31	21	.	.	.
cord-302082-aaokc182	32	1	Subunit	subunit	NN
cord-302082-aaokc182	32	2	and	and	CC
cord-302082-aaokc182	32	3	individual	individual	JJ
cord-302082-aaokc182	32	4	epitope	epitope	NN
cord-302082-aaokc182	32	5	vaccines	vaccine	NNS
cord-302082-aaokc182	32	6	need	need	VBP
cord-302082-aaokc182	32	7	to	to	TO
cord-302082-aaokc182	32	8	be	be	VB
cord-302082-aaokc182	32	9	optimised	optimise	VBN
cord-302082-aaokc182	32	10	to	to	TO
cord-302082-aaokc182	32	11	ensure	ensure	VB
cord-302082-aaokc182	32	12	adequate	adequate	JJ
cord-302082-aaokc182	32	13	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	32	14	.	.	.
cord-302082-aaokc182	33	1	Novel	novel	JJ
cord-302082-aaokc182	33	2	strategies	strategy	NNS
cord-302082-aaokc182	33	3	are	be	VBP
cord-302082-aaokc182	33	4	being	be	VBG
cord-302082-aaokc182	33	5	developed	develop	VBN
cord-302082-aaokc182	33	6	and	and	CC
cord-302082-aaokc182	33	7	exploited	exploit	VBN
cord-302082-aaokc182	33	8	in	in	IN
cord-302082-aaokc182	33	9	order	order	NN
cord-302082-aaokc182	33	10	to	to	TO
cord-302082-aaokc182	33	11	identify	identify	VB
cord-302082-aaokc182	33	12	antigens	antigen	NNS
cord-302082-aaokc182	33	13	recognised	recognise	VBN
cord-302082-aaokc182	33	14	by	by	IN
cord-302082-aaokc182	33	15	T	T	NNP
cord-302082-aaokc182	33	16	and	and	CC
cord-302082-aaokc182	33	17	B	b	NN
cord-302082-aaokc182	33	18	cells	cell	NNS
cord-302082-aaokc182	33	19	,	,	,
cord-302082-aaokc182	33	20	thus	thus	RB
cord-302082-aaokc182	33	21	facilitating	facilitate	VBG
cord-302082-aaokc182	33	22	a	a	DT
cord-302082-aaokc182	33	23	more	more	JJR
cord-302082-aaokc182	33	24	knowledge	knowledge	NN
cord-302082-aaokc182	33	25	-	-	HYPH
cord-302082-aaokc182	33	26	based	base	VBN
cord-302082-aaokc182	33	27	vaccine	vaccine	NN
cord-302082-aaokc182	33	28	design	design	NN
cord-302082-aaokc182	33	29	.	.	.
cord-302082-aaokc182	34	1	One	one	CD
cord-302082-aaokc182	34	2	of	of	IN
cord-302082-aaokc182	34	3	the	the	DT
cord-302082-aaokc182	34	4	most	most	RBS
cord-302082-aaokc182	34	5	common	common	JJ
cord-302082-aaokc182	34	6	ways	way	NNS
cord-302082-aaokc182	34	7	to	to	TO
cord-302082-aaokc182	34	8	identify	identify	VB
cord-302082-aaokc182	34	9	these	these	DT
cord-302082-aaokc182	34	10	antigens	antigen	NNS
cord-302082-aaokc182	34	11	is	be	VBZ
cord-302082-aaokc182	34	12	to	to	TO
cord-302082-aaokc182	34	13	measure	measure	VB
cord-302082-aaokc182	34	14	cellular	cellular	JJ
cord-302082-aaokc182	34	15	proliferation	proliferation	NN
cord-302082-aaokc182	34	16	(	(	-LRB-
cord-302082-aaokc182	34	17	T	t	NN
cord-302082-aaokc182	34	18	or	or	CC
cord-302082-aaokc182	34	19	B	b	NN
cord-302082-aaokc182	34	20	cells	cell	NNS
cord-302082-aaokc182	34	21	)	)	-RRB-
cord-302082-aaokc182	34	22	upon	upon	IN
cord-302082-aaokc182	34	23	in	in	FW
cord-302082-aaokc182	34	24	vitro	vitro	FW
cord-302082-aaokc182	34	25	stimulation	stimulation	NN
cord-302082-aaokc182	34	26	with	with	IN
cord-302082-aaokc182	34	27	antigen	antigen	NN
cord-302082-aaokc182	34	28	.	.	.
cord-302082-aaokc182	35	1	High	high	JJ
cord-302082-aaokc182	35	2	-	-	HYPH
cord-302082-aaokc182	35	3	throughput	throughput	NN
cord-302082-aaokc182	35	4	screening	screening	NN
cord-302082-aaokc182	35	5	assays	assay	NNS
cord-302082-aaokc182	35	6	of	of	IN
cord-302082-aaokc182	35	7	candidate	candidate	NN
cord-302082-aaokc182	35	8	synthetic	synthetic	JJ
cord-302082-aaokc182	35	9	peptides	peptide	NNS
cord-302082-aaokc182	35	10	that	that	WDT
cord-302082-aaokc182	35	11	drive	drive	VBP
cord-302082-aaokc182	35	12	cellular	cellular	JJ
cord-302082-aaokc182	35	13	proliferation	proliferation	NN
cord-302082-aaokc182	35	14	help	help	NN
cord-302082-aaokc182	35	15	speed	speed	VB
cord-302082-aaokc182	35	16	the	the	DT
cord-302082-aaokc182	35	17	rate	rate	NN
cord-302082-aaokc182	35	18	of	of	IN
cord-302082-aaokc182	35	19	antigen	antigen	NN
cord-302082-aaokc182	35	20	discovery	discovery	NN
cord-302082-aaokc182	35	21	.	.	.
cord-302082-aaokc182	36	1	Reverse	reverse	JJ
cord-302082-aaokc182	36	2	vaccinology	vaccinology	NN
cord-302082-aaokc182	36	3	combines	combine	VBZ
cord-302082-aaokc182	36	4	knowledge	knowledge	NN
cord-302082-aaokc182	36	5	of	of	IN
cord-302082-aaokc182	36	6	the	the	DT
cord-302082-aaokc182	36	7	pathogen	pathogen	NN
cord-302082-aaokc182	36	8	's	's	POS
cord-302082-aaokc182	36	9	genome	genome	NN
cord-302082-aaokc182	36	10	sequence	sequence	NN
cord-302082-aaokc182	36	11	with	with	IN
cord-302082-aaokc182	36	12	known	know	VBN
cord-302082-aaokc182	36	13	protein	protein	NN
cord-302082-aaokc182	36	14	sequences	sequence	NNS
cord-302082-aaokc182	36	15	via	via	IN
cord-302082-aaokc182	36	16	computer	computer	NN
cord-302082-aaokc182	36	17	analysis	analysis	NN
cord-302082-aaokc182	36	18	,	,	,
cord-302082-aaokc182	36	19	to	to	TO
cord-302082-aaokc182	36	20	predict	predict	VB
cord-302082-aaokc182	36	21	protein	protein	NN
cord-302082-aaokc182	36	22	expression	expression	NN
cord-302082-aaokc182	36	23	and	and	CC
cord-302082-aaokc182	36	24	post	post	JJ
cord-302082-aaokc182	36	25	-	-	JJ
cord-302082-aaokc182	36	26	translational	translational	JJ
cord-302082-aaokc182	36	27	modifications	modification	NNS
cord-302082-aaokc182	36	28	and	and	CC
cord-302082-aaokc182	36	29	identify	identify	VB
cord-302082-aaokc182	36	30	likely	likely	JJ
cord-302082-aaokc182	36	31	vaccine	vaccine	NN
cord-302082-aaokc182	36	32	candidates	candidate	NNS
cord-302082-aaokc182	36	33	(	(	-LRB-
cord-302082-aaokc182	36	34	see	see	VB
cord-302082-aaokc182	36	35	Chapter	chapter	NN
cord-302082-aaokc182	36	36	3	3	CD
cord-302082-aaokc182	36	37	e	e	NN
cord-302082-aaokc182	36	38	Vaccine	vaccine	NN
cord-302082-aaokc182	36	39	antigens	antigen	NNS
cord-302082-aaokc182	36	40	;	;	:
cord-302082-aaokc182	36	41	Figure	figure	NN
cord-302082-aaokc182	36	42	3	3	CD
cord-302082-aaokc182	36	43	.5	.5	CD
cord-302082-aaokc182	36	44	)	)	-RRB-
cord-302082-aaokc182	36	45	.	.	.
cord-302082-aaokc182	37	1	The	the	DT
cord-302082-aaokc182	37	2	development	development	NN
cord-302082-aaokc182	37	3	of	of	IN
cord-302082-aaokc182	37	4	epitope	epitope	NN
cord-302082-aaokc182	37	5	-	-	HYPH
cord-302082-aaokc182	37	6	based	base	VBN
cord-302082-aaokc182	37	7	vaccines	vaccine	NNS
cord-302082-aaokc182	37	8	is	be	VBZ
cord-302082-aaokc182	37	9	one	one	CD
cord-302082-aaokc182	37	10	example	example	NN
cord-302082-aaokc182	37	11	of	of	IN
cord-302082-aaokc182	37	12	reverse	reverse	JJ
cord-302082-aaokc182	37	13	vaccinology	vaccinology	NN
cord-302082-aaokc182	37	14	where	where	WRB
cord-302082-aaokc182	37	15	computer	computer	NN
cord-302082-aaokc182	37	16	software	software	NN
cord-302082-aaokc182	37	17	combines	combine	VBZ
cord-302082-aaokc182	37	18	prediction	prediction	NN
cord-302082-aaokc182	37	19	algorithms	algorithm	NNS
cord-302082-aaokc182	37	20	to	to	TO
cord-302082-aaokc182	37	21	suggest	suggest	VB
cord-302082-aaokc182	37	22	sequences	sequence	NNS
cord-302082-aaokc182	37	23	similar	similar	JJ
cord-302082-aaokc182	37	24	to	to	IN
cord-302082-aaokc182	37	25	those	those	DT
cord-302082-aaokc182	37	26	for	for	IN
cord-302082-aaokc182	37	27	pathogenic	pathogenic	JJ
cord-302082-aaokc182	37	28	components	component	NNS
cord-302082-aaokc182	37	29	.	.	.
cord-302082-aaokc182	38	1	Epitope	epitope	NN
cord-302082-aaokc182	38	2	mapping	mapping	NN
cord-302082-aaokc182	38	3	,	,	,
cord-302082-aaokc182	38	4	combined	combine	VBN
cord-302082-aaokc182	38	5	with	with	IN
cord-302082-aaokc182	38	6	the	the	DT
cord-302082-aaokc182	38	7	creation	creation	NN
cord-302082-aaokc182	38	8	of	of	IN
cord-302082-aaokc182	38	9	more	more	RBR
cord-302082-aaokc182	38	10	stable	stable	JJ
cord-302082-aaokc182	38	11	poly	poly	JJ
cord-302082-aaokc182	38	12	-	-	HYPH
cord-302082-aaokc182	38	13	epitope	epitope	JJ
cord-302082-aaokc182	38	14	vaccines	vaccine	NNS
cord-302082-aaokc182	38	15	,	,	,
cord-302082-aaokc182	38	16	may	may	MD
cord-302082-aaokc182	38	17	lead	lead	VB
cord-302082-aaokc182	38	18	to	to	IN
cord-302082-aaokc182	38	19	the	the	DT
cord-302082-aaokc182	38	20	successful	successful	JJ
cord-302082-aaokc182	38	21	translation	translation	NN
cord-302082-aaokc182	38	22	of	of	IN
cord-302082-aaokc182	38	23	this	this	DT
cord-302082-aaokc182	38	24	technology	technology	NN
cord-302082-aaokc182	38	25	into	into	IN
cord-302082-aaokc182	38	26	products	product	NNS
cord-302082-aaokc182	38	27	.	.	.
cord-302082-aaokc182	39	1	MHC	MHC	NNP
cord-302082-aaokc182	39	2	molecules	molecule	NNS
cord-302082-aaokc182	39	3	exhibit	exhibit	VBP
cord-302082-aaokc182	39	4	widely	widely	RB
cord-302082-aaokc182	39	5	varying	vary	VBG
cord-302082-aaokc182	39	6	binding	bind	VBG
cord-302082-aaokc182	39	7	specificities	specificity	NNS
cord-302082-aaokc182	39	8	;	;	:
cord-302082-aaokc182	39	9	a	a	DT
cord-302082-aaokc182	39	10	vaccine	vaccine	NN
cord-302082-aaokc182	39	11	expressing	express	VBG
cord-302082-aaokc182	39	12	a	a	DT
cord-302082-aaokc182	39	13	single	single	JJ
cord-302082-aaokc182	39	14	peptide	peptide	NN
cord-302082-aaokc182	39	15	antigen	antigen	NN
cord-302082-aaokc182	39	16	would	would	MD
cord-302082-aaokc182	39	17	therefore	therefore	RB
cord-302082-aaokc182	39	18	only	only	RB
cord-302082-aaokc182	39	19	target	target	VB
cord-302082-aaokc182	39	20	a	a	DT
cord-302082-aaokc182	39	21	few	few	JJ
cord-302082-aaokc182	39	22	MHC	MHC	NNP
cord-302082-aaokc182	39	23	molecules	molecule	NNS
cord-302082-aaokc182	39	24	and	and	CC
cord-302082-aaokc182	39	25	thus	thus	RB
cord-302082-aaokc182	39	26	only	only	RB
cord-302082-aaokc182	39	27	be	be	VB
cord-302082-aaokc182	39	28	recognised	recognise	VBN
cord-302082-aaokc182	39	29	by	by	IN
cord-302082-aaokc182	39	30	the	the	DT
cord-302082-aaokc182	39	31	T	T	NNP
cord-302082-aaokc182	39	32	cells	cell	NNS
cord-302082-aaokc182	39	33	of	of	IN
cord-302082-aaokc182	39	34	individuals	individual	NNS
cord-302082-aaokc182	39	35	carrying	carry	VBG
cord-302082-aaokc182	39	36	a	a	DT
cord-302082-aaokc182	39	37	specific	specific	JJ
cord-302082-aaokc182	39	38	MHC	MHC	NNP
cord-302082-aaokc182	39	39	phenotype	phenotype	NN
cord-302082-aaokc182	39	40	.	.	.
cord-302082-aaokc182	40	1	Poly	poly	NN
cord-302082-aaokc182	40	2	-	-	HYPH
cord-302082-aaokc182	40	3	epitope	epitope	NN
cord-302082-aaokc182	40	4	technology	technology	NN
cord-302082-aaokc182	40	5	could	could	MD
cord-302082-aaokc182	40	6	be	be	VB
cord-302082-aaokc182	40	7	used	use	VBN
cord-302082-aaokc182	40	8	to	to	TO
cord-302082-aaokc182	40	9	generate	generate	VB
cord-302082-aaokc182	40	10	a	a	DT
cord-302082-aaokc182	40	11	synthetic	synthetic	JJ
cord-302082-aaokc182	40	12	protein	protein	NN
cord-302082-aaokc182	40	13	carrying	carry	VBG
cord-302082-aaokc182	40	14	antigenic	antigenic	JJ
cord-302082-aaokc182	40	15	epitopes	epitope	NNS
cord-302082-aaokc182	40	16	from	from	IN
cord-302082-aaokc182	40	17	multiple	multiple	JJ
cord-302082-aaokc182	40	18	strains	strain	NNS
cord-302082-aaokc182	40	19	or	or	CC
cord-302082-aaokc182	40	20	pathogens	pathogen	NNS
cord-302082-aaokc182	40	21	.	.	.
cord-302082-aaokc182	41	1	This	this	DT
cord-302082-aaokc182	41	2	would	would	MD
cord-302082-aaokc182	41	3	overcome	overcome	VB
cord-302082-aaokc182	41	4	the	the	DT
cord-302082-aaokc182	41	5	MHC	MHC	NNP
cord-302082-aaokc182	41	6	restriction	restriction	NN
cord-302082-aaokc182	41	7	and	and	CC
cord-302082-aaokc182	41	8	afford	afford	VB
cord-302082-aaokc182	41	9	protection	protection	NN
cord-302082-aaokc182	41	10	in	in	IN
cord-302082-aaokc182	41	11	individuals	individual	NNS
cord-302082-aaokc182	41	12	carrying	carry	VBG
cord-302082-aaokc182	41	13	different	different	JJ
cord-302082-aaokc182	41	14	MHC	MHC	NNP
cord-302082-aaokc182	41	15	types	type	NNS
cord-302082-aaokc182	41	16	.	.	.
cord-302082-aaokc182	42	1	The	the	DT
cord-302082-aaokc182	42	2	screening	screening	NN
cord-302082-aaokc182	42	3	of	of	IN
cord-302082-aaokc182	42	4	pathogen	pathogen	NN
cord-302082-aaokc182	42	5	peptide	peptide	NN
cord-302082-aaokc182	42	6	libraries	library	NNS
cord-302082-aaokc182	42	7	is	be	VBZ
cord-302082-aaokc182	42	8	another	another	DT
cord-302082-aaokc182	42	9	example	example	NN
cord-302082-aaokc182	42	10	of	of	IN
cord-302082-aaokc182	42	11	new	new	JJ
cord-302082-aaokc182	42	12	approaches	approach	NNS
cord-302082-aaokc182	42	13	to	to	IN
cord-302082-aaokc182	42	14	antigen	antigen	NN
cord-302082-aaokc182	42	15	discovery	discovery	NN
cord-302082-aaokc182	42	16	.	.	.
cord-302082-aaokc182	43	1	Screening	screening	NN
cord-302082-aaokc182	43	2	methods	method	NNS
cord-302082-aaokc182	43	3	are	be	VBP
cord-302082-aaokc182	43	4	used	use	VBN
cord-302082-aaokc182	43	5	to	to	TO
cord-302082-aaokc182	43	6	identify	identify	VB
cord-302082-aaokc182	43	7	antigens	antigen	NNS
cord-302082-aaokc182	43	8	that	that	WDT
cord-302082-aaokc182	43	9	can	can	MD
cord-302082-aaokc182	43	10	stimulate	stimulate	VB
cord-302082-aaokc182	43	11	CD4	CD4	NNP
cord-302082-aaokc182	43	12	þ	þ	NNP
cord-302082-aaokc182	43	13	or	or	CC
cord-302082-aaokc182	43	14	CD8	CD8	NNP
cord-302082-aaokc182	43	15	þ	þ	NNP
cord-302082-aaokc182	43	16	T	T	NNP
cord-302082-aaokc182	43	17	cells	cell	NNS
cord-302082-aaokc182	43	18	,	,	,
cord-302082-aaokc182	43	19	or	or	CC
cord-302082-aaokc182	43	20	which	which	WDT
cord-302082-aaokc182	43	21	bind	bind	VBP
cord-302082-aaokc182	43	22	to	to	IN
cord-302082-aaokc182	43	23	antibodies	antibody	NNS
cord-302082-aaokc182	43	24	from	from	IN
cord-302082-aaokc182	43	25	humans	human	NNS
cord-302082-aaokc182	43	26	known	know	VBN
cord-302082-aaokc182	43	27	to	to	TO
cord-302082-aaokc182	43	28	have	have	VB
cord-302082-aaokc182	43	29	been	be	VBN
cord-302082-aaokc182	43	30	infected	infect	VBN
cord-302082-aaokc182	43	31	with	with	IN
cord-302082-aaokc182	43	32	the	the	DT
cord-302082-aaokc182	43	33	relevant	relevant	JJ
cord-302082-aaokc182	43	34	pathogen	pathogen	NN
cord-302082-aaokc182	43	35	.	.	.
cord-302082-aaokc182	44	1	Where	where	WRB
cord-302082-aaokc182	44	2	peptide	peptide	NN
cord-302082-aaokc182	44	3	screening	screening	NN
cord-302082-aaokc182	44	4	uses	use	VBZ
cord-302082-aaokc182	44	5	antibodies	antibody	NNS
cord-302082-aaokc182	44	6	,	,	,
cord-302082-aaokc182	44	7	an	an	DT
cord-302082-aaokc182	44	8	additional	additional	JJ
cord-302082-aaokc182	44	9	consideration	consideration	NN
cord-302082-aaokc182	44	10	is	be	VBZ
cord-302082-aaokc182	44	11	the	the	DT
cord-302082-aaokc182	44	12	synthesis	synthesis	NN
cord-302082-aaokc182	44	13	of	of	IN
cord-302082-aaokc182	44	14	antigens	antigen	NNS
cord-302082-aaokc182	44	15	that	that	WDT
cord-302082-aaokc182	44	16	contain	contain	VBP
cord-302082-aaokc182	44	17	the	the	DT
cord-302082-aaokc182	44	18	tertiary	tertiary	JJ
cord-302082-aaokc182	44	19	(	(	-LRB-
cord-302082-aaokc182	44	20	folding	fold	VBG
cord-302082-aaokc182	44	21	/	/	SYM
cord-302082-aaokc182	44	22	three	three	CD
cord-302082-aaokc182	44	23	-	-	HYPH
cord-302082-aaokc182	44	24	dimensional	dimensional	JJ
cord-302082-aaokc182	44	25	)	)	-RRB-
cord-302082-aaokc182	44	26	structure	structure	NN
cord-302082-aaokc182	44	27	of	of	IN
cord-302082-aaokc182	44	28	the	the	DT
cord-302082-aaokc182	44	29	native	native	JJ
cord-302082-aaokc182	44	30	immunogen	immunogen	NN
cord-302082-aaokc182	44	31	,	,	,
cord-302082-aaokc182	44	32	since	since	IN
cord-302082-aaokc182	44	33	vaccine	vaccine	NN
cord-302082-aaokc182	44	34	efficacy	efficacy	NN
cord-302082-aaokc182	44	35	can	can	MD
cord-302082-aaokc182	44	36	be	be	VB
cord-302082-aaokc182	44	37	impacted	impact	VBN
cord-302082-aaokc182	44	38	by	by	IN
cord-302082-aaokc182	44	39	infidelities	infidelity	NNS
cord-302082-aaokc182	44	40	in	in	IN
cord-302082-aaokc182	44	41	the	the	DT
cord-302082-aaokc182	44	42	structure	structure	NN
cord-302082-aaokc182	44	43	of	of	IN
cord-302082-aaokc182	44	44	the	the	DT
cord-302082-aaokc182	44	45	final	final	JJ
cord-302082-aaokc182	44	46	product	product	NN
cord-302082-aaokc182	44	47	.	.	.
cord-302082-aaokc182	45	1	Incorrect	incorrect	JJ
cord-302082-aaokc182	45	2	protein	protein	NN
cord-302082-aaokc182	45	3	folding	folding	NN
cord-302082-aaokc182	45	4	may	may	MD
cord-302082-aaokc182	45	5	result	result	VB
cord-302082-aaokc182	45	6	in	in	IN
cord-302082-aaokc182	45	7	a	a	DT
cord-302082-aaokc182	45	8	less	less	RBR
cord-302082-aaokc182	45	9	immunogenic	immunogenic	JJ
cord-302082-aaokc182	45	10	antigen	antigen	NN
cord-302082-aaokc182	45	11	or	or	CC
cord-302082-aaokc182	45	12	an	an	DT
cord-302082-aaokc182	45	13	antigen	antigen	NN
cord-302082-aaokc182	45	14	that	that	WDT
cord-302082-aaokc182	45	15	induces	induce	VBZ
cord-302082-aaokc182	45	16	an	an	DT
cord-302082-aaokc182	45	17	immune	immune	JJ
cord-302082-aaokc182	45	18	response	response	NN
cord-302082-aaokc182	45	19	that	that	WDT
cord-302082-aaokc182	45	20	differs	differ	VBZ
cord-302082-aaokc182	45	21	from	from	IN
cord-302082-aaokc182	45	22	that	that	DT
cord-302082-aaokc182	45	23	of	of	IN
cord-302082-aaokc182	45	24	the	the	DT
cord-302082-aaokc182	45	25	native	native	JJ
cord-302082-aaokc182	45	26	immunogen	immunogen	NN
cord-302082-aaokc182	45	27	.	.	.
cord-302082-aaokc182	46	1	The	the	DT
cord-302082-aaokc182	46	2	mimicking	mimicking	NN
cord-302082-aaokc182	46	3	of	of	IN
cord-302082-aaokc182	46	4	the	the	DT
cord-302082-aaokc182	46	5	three	three	CD
cord-302082-aaokc182	46	6	-	-	HYPH
cord-302082-aaokc182	46	7	dimensional	dimensional	JJ
cord-302082-aaokc182	46	8	structure	structure	NN
cord-302082-aaokc182	46	9	of	of	IN
cord-302082-aaokc182	46	10	the	the	DT
cord-302082-aaokc182	46	11	native	native	JJ
cord-302082-aaokc182	46	12	immunogen	immunogen	NN
cord-302082-aaokc182	46	13	is	be	VBZ
cord-302082-aaokc182	46	14	important	important	JJ
cord-302082-aaokc182	46	15	during	during	IN
cord-302082-aaokc182	46	16	the	the	DT
cord-302082-aaokc182	46	17	synthesis	synthesis	NN
cord-302082-aaokc182	46	18	of	of	IN
cord-302082-aaokc182	46	19	antigens	antigen	NNS
cord-302082-aaokc182	46	20	that	that	WDT
cord-302082-aaokc182	46	21	are	be	VBP
cord-302082-aaokc182	46	22	being	be	VBG
cord-302082-aaokc182	46	23	used	use	VBN
cord-302082-aaokc182	46	24	to	to	TO
cord-302082-aaokc182	46	25	target	target	VB
cord-302082-aaokc182	46	26	B	b	NN
cord-302082-aaokc182	46	27	-	-	HYPH
cord-302082-aaokc182	46	28	cell	cell	NN
cord-302082-aaokc182	46	29	responses	response	NNS
cord-302082-aaokc182	46	30	.	.	.
cord-302082-aaokc182	47	1	Conversely	conversely	RB
cord-302082-aaokc182	47	2	,	,	,
cord-302082-aaokc182	47	3	the	the	DT
cord-302082-aaokc182	47	4	requirement	requirement	NN
cord-302082-aaokc182	47	5	for	for	IN
cord-302082-aaokc182	47	6	folding	folding	NN
cord-302082-aaokc182	47	7	is	be	VBZ
cord-302082-aaokc182	47	8	reduced	reduce	VBN
cord-302082-aaokc182	47	9	for	for	IN
cord-302082-aaokc182	47	10	T	t	NN
cord-302082-aaokc182	47	11	cells	cell	NNS
cord-302082-aaokc182	47	12	since	since	IN
cord-302082-aaokc182	47	13	T	T	NNP
cord-302082-aaokc182	47	14	cells	cell	NNS
cord-302082-aaokc182	47	15	bind	bind	VBP
cord-302082-aaokc182	47	16	only	only	RB
cord-302082-aaokc182	47	17	processed	process	VBN
cord-302082-aaokc182	47	18	peptides	peptide	NNS
cord-302082-aaokc182	47	19	,	,	,
cord-302082-aaokc182	47	20	from	from	IN
cord-302082-aaokc182	47	21	degraded	degraded	JJ
cord-302082-aaokc182	47	22	proteins	protein	NNS
cord-302082-aaokc182	47	23	.	.	.
cord-302082-aaokc182	48	1	Likewise	likewise	RB
cord-302082-aaokc182	48	2	,	,	,
cord-302082-aaokc182	48	3	DNA	dna	NN
cord-302082-aaokc182	48	4	expression	expression	NN
cord-302082-aaokc182	48	5	libraries	library	NNS
cord-302082-aaokc182	48	6	using	use	VBG
cord-302082-aaokc182	48	7	the	the	DT
cord-302082-aaokc182	48	8	pathogen	pathogen	NN
cord-302082-aaokc182	48	9	genomic	genomic	JJ
cord-302082-aaokc182	48	10	DNA	dna	NN
cord-302082-aaokc182	48	11	have	have	VBP
cord-302082-aaokc182	48	12	been	be	VBN
cord-302082-aaokc182	48	13	screened	screen	VBN
cord-302082-aaokc182	48	14	using	use	VBG
cord-302082-aaokc182	48	15	animal	animal	NN
cord-302082-aaokc182	48	16	model	model	NN
cord-302082-aaokc182	48	17	systems	system	NNS
cord-302082-aaokc182	48	18	to	to	TO
cord-302082-aaokc182	48	19	identify	identify	VB
cord-302082-aaokc182	48	20	genes	gene	NNS
cord-302082-aaokc182	48	21	encoding	encode	VBG
cord-302082-aaokc182	48	22	proteins	protein	NNS
cord-302082-aaokc182	48	23	that	that	WDT
cord-302082-aaokc182	48	24	afford	afford	VBP
cord-302082-aaokc182	48	25	protection	protection	NN
cord-302082-aaokc182	48	26	against	against	IN
cord-302082-aaokc182	48	27	infection	infection	NN
cord-302082-aaokc182	48	28	or	or	CC
cord-302082-aaokc182	48	29	disease	disease	NN
cord-302082-aaokc182	48	30	caused	cause	VBN
cord-302082-aaokc182	48	31	by	by	IN
cord-302082-aaokc182	48	32	the	the	DT
cord-302082-aaokc182	48	33	pathogen	pathogen	NN
cord-302082-aaokc182	48	34	.	.	.
cord-302082-aaokc182	49	1	One	one	CD
cord-302082-aaokc182	49	2	example	example	NN
cord-302082-aaokc182	49	3	is	be	VBZ
cord-302082-aaokc182	49	4	Genocea	Genocea	NNP
cord-302082-aaokc182	49	5	's	's	POS
cord-302082-aaokc182	49	6	vaccine	vaccine	NN
cord-302082-aaokc182	49	7	development	development	NN
cord-302082-aaokc182	49	8	programmes	programme	NNS
cord-302082-aaokc182	49	9	that	that	WDT
cord-302082-aaokc182	49	10	are	be	VBP
cord-302082-aaokc182	49	11	built	build	VBN
cord-302082-aaokc182	49	12	around	around	IN
cord-302082-aaokc182	49	13	a	a	DT
cord-302082-aaokc182	49	14	broad	broad	JJ
cord-302082-aaokc182	49	15	platform	platform	NN
cord-302082-aaokc182	49	16	for	for	IN
cord-302082-aaokc182	49	17	the	the	DT
cord-302082-aaokc182	49	18	rapid	rapid	JJ
cord-302082-aaokc182	49	19	discovery	discovery	NN
cord-302082-aaokc182	49	20	of	of	IN
cord-302082-aaokc182	49	21	T	t	NN
cord-302082-aaokc182	49	22	-	-	HYPH
cord-302082-aaokc182	49	23	cell	cell	NN
cord-302082-aaokc182	49	24	antigens	antigen	NNS
cord-302082-aaokc182	49	25	.	.	.
cord-302082-aaokc182	50	1	The	the	DT
cord-302082-aaokc182	50	2	process	process	NN
cord-302082-aaokc182	50	3	is	be	VBZ
cord-302082-aaokc182	50	4	explained	explain	VBN
cord-302082-aaokc182	50	5	in	in	IN
cord-302082-aaokc182	50	6	Figure	Figure	NNP
cord-302082-aaokc182	50	7	6	6	CD
cord-302082-aaokc182	50	8	.3	.3	NFP
cord-302082-aaokc182	50	9	.	.	.
cord-302082-aaokc182	51	1	T	t	NN
cord-302082-aaokc182	51	2	-	-	HYPH
cord-302082-aaokc182	51	3	cell	cell	NN
cord-302082-aaokc182	51	4	antigens	antigen	NNS
cord-302082-aaokc182	51	5	,	,	,
cord-302082-aaokc182	51	6	specifically	specifically	RB
cord-302082-aaokc182	51	7	antigens	antigen	NNS
cord-302082-aaokc182	51	8	that	that	WDT
cord-302082-aaokc182	51	9	stimulate	stimulate	VBP
cord-302082-aaokc182	51	10	CD4	CD4	NNP
cord-302082-aaokc182	51	11	þ	þ	NNP
cord-302082-aaokc182	51	12	and	and	CC
cord-302082-aaokc182	51	13	CD8	CD8	NNP
cord-302082-aaokc182	51	14	þ	þ	NNP
cord-302082-aaokc182	51	15	T	T	NNP
cord-302082-aaokc182	51	16	cells	cell	NNS
cord-302082-aaokc182	51	17	,	,	,
cord-302082-aaokc182	51	18	are	be	VBP
cord-302082-aaokc182	51	19	critical	critical	JJ
cord-302082-aaokc182	51	20	to	to	IN
cord-302082-aaokc182	51	21	generating	generate	VBG
cord-302082-aaokc182	51	22	disease	disease	NN
cord-302082-aaokc182	51	23	-	-	HYPH
cord-302082-aaokc182	51	24	specific	specific	JJ
cord-302082-aaokc182	51	25	cellular	cellular	JJ
cord-302082-aaokc182	51	26	immune	immune	JJ
cord-302082-aaokc182	51	27	responses	response	NNS
cord-302082-aaokc182	51	28	and	and	CC
cord-302082-aaokc182	51	29	long	long	JJ
cord-302082-aaokc182	51	30	-	-	HYPH
cord-302082-aaokc182	51	31	term	term	NN
cord-302082-aaokc182	51	32	T	t	NN
cord-302082-aaokc182	51	33	-	-	HYPH
cord-302082-aaokc182	51	34	cell	cell	NN
cord-302082-aaokc182	51	35	memory	memory	NN
cord-302082-aaokc182	51	36	.	.	.
cord-302082-aaokc182	52	1	Stability	stability	NN
cord-302082-aaokc182	52	2	of	of	IN
cord-302082-aaokc182	52	3	the	the	DT
cord-302082-aaokc182	52	4	final	final	JJ
cord-302082-aaokc182	52	5	product	product	NN
cord-302082-aaokc182	52	6	is	be	VBZ
cord-302082-aaokc182	52	7	another	another	DT
cord-302082-aaokc182	52	8	important	important	JJ
cord-302082-aaokc182	52	9	consideration	consideration	NN
cord-302082-aaokc182	52	10	.	.	.
cord-302082-aaokc182	53	1	Adverse	adverse	JJ
cord-302082-aaokc182	53	2	environmental	environmental	JJ
cord-302082-aaokc182	53	3	conditions	condition	NNS
cord-302082-aaokc182	53	4	can	can	MD
cord-302082-aaokc182	53	5	result	result	VB
cord-302082-aaokc182	53	6	in	in	IN
cord-302082-aaokc182	53	7	degradation	degradation	NN
cord-302082-aaokc182	53	8	of	of	IN
cord-302082-aaokc182	53	9	the	the	DT
cord-302082-aaokc182	53	10	vaccine	vaccine	NN
cord-302082-aaokc182	53	11	,	,	,
cord-302082-aaokc182	53	12	rendering	render	VBG
cord-302082-aaokc182	53	13	it	-PRON-	PRP
cord-302082-aaokc182	53	14	non	non	JJ
cord-302082-aaokc182	53	15	-	-	JJ
cord-302082-aaokc182	53	16	immunogenic	immunogenic	JJ
cord-302082-aaokc182	53	17	.	.	.
cord-302082-aaokc182	54	1	In	in	IN
cord-302082-aaokc182	54	2	order	order	NN
cord-302082-aaokc182	54	3	to	to	TO
cord-302082-aaokc182	54	4	maintain	maintain	VB
cord-302082-aaokc182	54	5	product	product	NN
cord-302082-aaokc182	54	6	integrity	integrity	NN
cord-302082-aaokc182	54	7	many	many	JJ
cord-302082-aaokc182	54	8	vaccines	vaccine	NNS
cord-302082-aaokc182	54	9	(	(	-LRB-
cord-302082-aaokc182	54	10	particularly	particularly	RB
cord-302082-aaokc182	54	11	live	live	JJ
cord-302082-aaokc182	54	12	vaccines	vaccine	NNS
cord-302082-aaokc182	54	13	)	)	-RRB-
cord-302082-aaokc182	54	14	must	must	MD
cord-302082-aaokc182	54	15	be	be	VB
cord-302082-aaokc182	54	16	stored	store	VBN
cord-302082-aaokc182	54	17	at	at	IN
cord-302082-aaokc182	54	18	cold	cold	JJ
cord-302082-aaokc182	54	19	temperatures	temperature	NNS
cord-302082-aaokc182	54	20	(	(	-LRB-
cord-302082-aaokc182	54	21	4	4	CD
cord-302082-aaokc182	54	22	C	C	NNP
cord-302082-aaokc182	54	23	)	)	-RRB-
cord-302082-aaokc182	54	24	.	.	.
cord-302082-aaokc182	55	1	The	the	DT
cord-302082-aaokc182	55	2	maintenance	maintenance	NN
cord-302082-aaokc182	55	3	of	of	IN
cord-302082-aaokc182	55	4	the	the	DT
cord-302082-aaokc182	55	5	vaccine	vaccine	NN
cord-302082-aaokc182	55	6	at	at	IN
cord-302082-aaokc182	55	7	this	this	DT
cord-302082-aaokc182	55	8	temperature	temperature	NN
cord-302082-aaokc182	55	9	from	from	IN
cord-302082-aaokc182	55	10	production	production	NN
cord-302082-aaokc182	55	11	site	site	NN
cord-302082-aaokc182	55	12	to	to	IN
cord-302082-aaokc182	55	13	distribution	distribution	NN
cord-302082-aaokc182	55	14	site	site	NN
cord-302082-aaokc182	55	15	,	,	,
cord-302082-aaokc182	55	16	and	and	CC
cord-302082-aaokc182	55	17	medical	medical	JJ
cord-302082-aaokc182	55	18	office	office	NN
cord-302082-aaokc182	55	19	or	or	CC
cord-302082-aaokc182	55	20	clinic	clinic	NN
cord-302082-aaokc182	55	21	,	,	,
cord-302082-aaokc182	55	22	is	be	VBZ
cord-302082-aaokc182	55	23	referred	refer	VBN
cord-302082-aaokc182	55	24	to	to	IN
cord-302082-aaokc182	55	25	as	as	IN
cord-302082-aaokc182	55	26	the	the	DT
cord-302082-aaokc182	55	27	'	'	``
cord-302082-aaokc182	55	28	cold	cold	JJ
cord-302082-aaokc182	55	29	chain	chain	NN
cord-302082-aaokc182	55	30	'	'	''
cord-302082-aaokc182	55	31	.	.	.
cord-302082-aaokc182	56	1	Maintaining	maintain	VBG
cord-302082-aaokc182	56	2	the	the	DT
cord-302082-aaokc182	56	3	cold	cold	JJ
cord-302082-aaokc182	56	4	chain	chain	NN
cord-302082-aaokc182	56	5	is	be	VBZ
cord-302082-aaokc182	56	6	much	much	RB
cord-302082-aaokc182	56	7	less	less	JJR
cord-302082-aaokc182	56	8	of	of	IN
cord-302082-aaokc182	56	9	a	a	DT
cord-302082-aaokc182	56	10	challenge	challenge	NN
cord-302082-aaokc182	56	11	in	in	IN
cord-302082-aaokc182	56	12	resource	resource	NN
cord-302082-aaokc182	56	13	-	-	HYPH
cord-302082-aaokc182	56	14	rich	rich	JJ
cord-302082-aaokc182	56	15	countries	country	NNS
cord-302082-aaokc182	56	16	,	,	,
cord-302082-aaokc182	56	17	but	but	CC
cord-302082-aaokc182	56	18	can	can	MD
cord-302082-aaokc182	56	19	be	be	VB
cord-302082-aaokc182	56	20	a	a	DT
cord-302082-aaokc182	56	21	major	major	JJ
cord-302082-aaokc182	56	22	barrier	barrier	NN
cord-302082-aaokc182	56	23	to	to	IN
cord-302082-aaokc182	56	24	vaccine	vaccine	NN
cord-302082-aaokc182	56	25	implementation	implementation	NN
cord-302082-aaokc182	56	26	in	in	IN
cord-302082-aaokc182	56	27	resource	resource	NN
cord-302082-aaokc182	56	28	-	-	HYPH
cord-302082-aaokc182	56	29	limited	limit	VBN
cord-302082-aaokc182	56	30	areas	area	NNS
cord-302082-aaokc182	56	31	.	.	.
cord-302082-aaokc182	57	1	Ongoing	ongoing	JJ
cord-302082-aaokc182	57	2	research	research	NN
cord-302082-aaokc182	57	3	designed	design	VBN
cord-302082-aaokc182	57	4	to	to	TO
cord-302082-aaokc182	57	5	increase	increase	VB
cord-302082-aaokc182	57	6	our	-PRON-	PRP$
cord-302082-aaokc182	57	7	understanding	understanding	NN
cord-302082-aaokc182	57	8	of	of	IN
cord-302082-aaokc182	57	9	vaccine	vaccine	NN
cord-302082-aaokc182	57	10	degradation	degradation	NN
cord-302082-aaokc182	57	11	may	may	MD
cord-302082-aaokc182	57	12	address	address	VB
cord-302082-aaokc182	57	13	the	the	DT
cord-302082-aaokc182	57	14	problems	problem	NNS
cord-302082-aaokc182	57	15	associated	associate	VBN
cord-302082-aaokc182	57	16	with	with	IN
cord-302082-aaokc182	57	17	cold	cold	JJ
cord-302082-aaokc182	57	18	chain	chain	NN
cord-302082-aaokc182	57	19	management	management	NN
cord-302082-aaokc182	57	20	and	and	CC
cord-302082-aaokc182	57	21	lead	lead	VB
cord-302082-aaokc182	57	22	to	to	IN
cord-302082-aaokc182	57	23	the	the	DT
cord-302082-aaokc182	57	24	development	development	NN
cord-302082-aaokc182	57	25	of	of	IN
cord-302082-aaokc182	57	26	thermostable	thermostable	JJ
cord-302082-aaokc182	57	27	vaccines	vaccine	NNS
cord-302082-aaokc182	57	28	.	.	.
cord-302082-aaokc182	58	1	The	the	DT
cord-302082-aaokc182	58	2	level	level	NN
cord-302082-aaokc182	58	3	of	of	IN
cord-302082-aaokc182	58	4	antigen	antigen	NN
cord-302082-aaokc182	58	5	presentation	presentation	NN
cord-302082-aaokc182	58	6	which	which	WDT
cord-302082-aaokc182	58	7	occurs	occur	VBZ
cord-302082-aaokc182	58	8	with	with	IN
cord-302082-aaokc182	58	9	some	some	DT
cord-302082-aaokc182	58	10	current	current	JJ
cord-302082-aaokc182	58	11	vaccines	vaccine	NNS
cord-302082-aaokc182	58	12	may	may	MD
cord-302082-aaokc182	58	13	sometimes	sometimes	RB
cord-302082-aaokc182	58	14	be	be	VB
cord-302082-aaokc182	58	15	insufficient	insufficient	JJ
cord-302082-aaokc182	58	16	to	to	TO
cord-302082-aaokc182	58	17	drive	drive	VB
cord-302082-aaokc182	58	18	long	long	RB
cord-302082-aaokc182	58	19	-	-	HYPH
cord-302082-aaokc182	58	20	lasting	last	VBG
cord-302082-aaokc182	58	21	immune	immune	JJ
cord-302082-aaokc182	58	22	responses	response	NNS
cord-302082-aaokc182	58	23	of	of	IN
cord-302082-aaokc182	58	24	high	high	JJ
cord-302082-aaokc182	58	25	quality	quality	NN
cord-302082-aaokc182	58	26	(	(	-LRB-
cord-302082-aaokc182	58	27	see	see	VB
cord-302082-aaokc182	58	28	Chapter	chapter	NN
cord-302082-aaokc182	58	29	3	3	CD
cord-302082-aaokc182	58	30	e	e	NN
cord-302082-aaokc182	58	31	Vaccine	vaccine	NN
cord-302082-aaokc182	58	32	antigens	antigen	NNS
cord-302082-aaokc182	58	33	)	)	-RRB-
cord-302082-aaokc182	58	34	.	.	.
cord-302082-aaokc182	59	1	This	this	DT
cord-302082-aaokc182	59	2	may	may	MD
cord-302082-aaokc182	59	3	be	be	VB
cord-302082-aaokc182	59	4	due	due	JJ
cord-302082-aaokc182	59	5	to	to	IN
cord-302082-aaokc182	59	6	inadequate	inadequate	JJ
cord-302082-aaokc182	59	7	exposure	exposure	NN
cord-302082-aaokc182	59	8	of	of	IN
cord-302082-aaokc182	59	9	the	the	DT
cord-302082-aaokc182	59	10	antigen	antigen	NN
cord-302082-aaokc182	59	11	to	to	IN
cord-302082-aaokc182	59	12	immature	immature	JJ
cord-302082-aaokc182	59	13	antigen	antigen	NN
cord-302082-aaokc182	59	14	-	-	HYPH
cord-302082-aaokc182	59	15	presenting	present	VBG
cord-302082-aaokc182	59	16	cells	cell	NNS
cord-302082-aaokc182	59	17	(	(	-LRB-
cord-302082-aaokc182	59	18	APCs	apc	NNS
cord-302082-aaokc182	59	19	)	)	-RRB-
cord-302082-aaokc182	59	20	rapid	rapid	JJ
cord-302082-aaokc182	59	21	or	or	CC
cord-302082-aaokc182	59	22	subimmunogenic	subimmunogenic	JJ
cord-302082-aaokc182	59	23	degradation	degradation	NN
cord-302082-aaokc182	59	24	or	or	CC
cord-302082-aaokc182	59	25	sequestration	sequestration	NN
cord-302082-aaokc182	59	26	of	of	IN
cord-302082-aaokc182	59	27	antigens	antigen	NNS
cord-302082-aaokc182	59	28	,	,	,
cord-302082-aaokc182	59	29	or	or	CC
cord-302082-aaokc182	59	30	lack	lack	NN
cord-302082-aaokc182	59	31	of	of	IN
cord-302082-aaokc182	59	32	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	59	33	due	due	IN
cord-302082-aaokc182	59	34	to	to	IN
cord-302082-aaokc182	59	35	the	the	DT
cord-302082-aaokc182	59	36	physical	physical	JJ
cord-302082-aaokc182	59	37	presentation	presentation	NN
cord-302082-aaokc182	59	38	of	of	IN
cord-302082-aaokc182	59	39	the	the	DT
cord-302082-aaokc182	59	40	antigen	antigen	NN
cord-302082-aaokc182	59	41	.	.	.
cord-302082-aaokc182	60	1	The	the	DT
cord-302082-aaokc182	60	2	discovery	discovery	NN
cord-302082-aaokc182	60	3	and	and	CC
cord-302082-aaokc182	60	4	 	 	_SP
cord-302082-aaokc182	60	5	Modifying	modify	VBG
cord-302082-aaokc182	60	6	vaccine	vaccine	NN
cord-302082-aaokc182	60	7	formulations	formulation	NNS
cord-302082-aaokc182	60	8	to	to	TO
cord-302082-aaokc182	60	9	increase	increase	VB
cord-302082-aaokc182	60	10	tolerance	tolerance	NN
cord-302082-aaokc182	60	11	to	to	IN
cord-302082-aaokc182	60	12	temperature	temperature	NN
cord-302082-aaokc182	60	13	fluctuations	fluctuation	NNS
cord-302082-aaokc182	60	14	is	be	VBZ
cord-302082-aaokc182	60	15	likely	likely	JJ
cord-302082-aaokc182	60	16	to	to	TO
cord-302082-aaokc182	60	17	increase	increase	VB
cord-302082-aaokc182	60	18	the	the	DT
cord-302082-aaokc182	60	19	shelf	shelf	NN
cord-302082-aaokc182	60	20	-	-	HYPH
cord-302082-aaokc182	60	21	life	life	NN
cord-302082-aaokc182	60	22	of	of	IN
cord-302082-aaokc182	60	23	the	the	DT
cord-302082-aaokc182	60	24	product	product	NN
cord-302082-aaokc182	60	25	and	and	CC
cord-302082-aaokc182	60	26	reduce	reduce	VB
cord-302082-aaokc182	60	27	transport	transport	NN
cord-302082-aaokc182	60	28	and	and	CC
cord-302082-aaokc182	60	29	wastage	wastage	NN
cord-302082-aaokc182	60	30	issues	issue	NNS
cord-302082-aaokc182	60	31	.	.	.
cord-302082-aaokc182	61	1	UNDERSTANDING	understand	VBG
cord-302082-aaokc182	61	2	MODERN	modern	JJ
cord-302082-aaokc182	61	3	VACCINES	vaccine	NNS
cord-302082-aaokc182	61	4	refinement	refinement	NN
cord-302082-aaokc182	61	5	of	of	IN
cord-302082-aaokc182	61	6	new	new	JJ
cord-302082-aaokc182	61	7	and	and	CC
cord-302082-aaokc182	61	8	varied	varied	JJ
cord-302082-aaokc182	61	9	options	option	NNS
cord-302082-aaokc182	61	10	for	for	IN
cord-302082-aaokc182	61	11	antigen	antigen	NN
cord-302082-aaokc182	61	12	presentation	presentation	NN
cord-302082-aaokc182	61	13	is	be	VBZ
cord-302082-aaokc182	61	14	expected	expect	VBN
cord-302082-aaokc182	61	15	to	to	TO
cord-302082-aaokc182	61	16	allow	allow	VB
cord-302082-aaokc182	61	17	the	the	DT
cord-302082-aaokc182	61	18	design	design	NN
cord-302082-aaokc182	61	19	of	of	IN
cord-302082-aaokc182	61	20	vaccines	vaccine	NNS
cord-302082-aaokc182	61	21	to	to	TO
cord-302082-aaokc182	61	22	produce	produce	VB
cord-302082-aaokc182	61	23	specific	specific	JJ
cord-302082-aaokc182	61	24	immune	immune	JJ
cord-302082-aaokc182	61	25	profiles	profile	NNS
cord-302082-aaokc182	61	26	.	.	.
cord-302082-aaokc182	62	1	Some	some	DT
cord-302082-aaokc182	62	2	of	of	IN
cord-302082-aaokc182	62	3	these	these	DT
cord-302082-aaokc182	62	4	technologies	technology	NNS
cord-302082-aaokc182	62	5	have	have	VBP
cord-302082-aaokc182	62	6	been	be	VBN
cord-302082-aaokc182	62	7	shown	show	VBN
cord-302082-aaokc182	62	8	to	to	TO
cord-302082-aaokc182	62	9	facilitate	facilitate	VB
cord-302082-aaokc182	62	10	oral	oral	JJ
cord-302082-aaokc182	62	11	delivery	delivery	NN
cord-302082-aaokc182	62	12	to	to	TO
cord-302082-aaokc182	62	13	target	target	VB
cord-302082-aaokc182	62	14	mucosal	mucosal	JJ
cord-302082-aaokc182	62	15	immune	immune	JJ
cord-302082-aaokc182	62	16	responses	response	NNS
cord-302082-aaokc182	62	17	and	and	CC
cord-302082-aaokc182	62	18	also	also	RB
cord-302082-aaokc182	62	19	trigger	trigger	VB
cord-302082-aaokc182	62	20	both	both	DT
cord-302082-aaokc182	62	21	innate	innate	JJ
cord-302082-aaokc182	62	22	and	and	CC
cord-302082-aaokc182	62	23	adaptive	adaptive	JJ
cord-302082-aaokc182	62	24	immune	immune	JJ
cord-302082-aaokc182	62	25	systems	system	NNS
cord-302082-aaokc182	62	26	,	,	,
cord-302082-aaokc182	62	27	including	include	VBG
cord-302082-aaokc182	62	28	T	t	NN
cord-302082-aaokc182	62	29	-	-	HYPH
cord-302082-aaokc182	62	30	and	and	CC
cord-302082-aaokc182	62	31	B	b	NN
cord-302082-aaokc182	62	32	-	-	HYPH
cord-302082-aaokc182	62	33	cell	cell	NN
cord-302082-aaokc182	62	34	effector	effector	NN
cord-302082-aaokc182	62	35	and	and	CC
cord-302082-aaokc182	62	36	memory	memory	NN
cord-302082-aaokc182	62	37	responses	response	NNS
cord-302082-aaokc182	62	38	.	.	.
cord-302082-aaokc182	63	1	Candidate	candidate	NN
cord-302082-aaokc182	63	2	viral	viral	JJ
cord-302082-aaokc182	63	3	vector	vector	NN
cord-302082-aaokc182	63	4	vaccines	vaccine	NNS
cord-302082-aaokc182	63	5	utilise	utilise	VBP
cord-302082-aaokc182	63	6	a	a	DT
cord-302082-aaokc182	63	7	non	non	JJ
cord-302082-aaokc182	63	8	-	-	JJ
cord-302082-aaokc182	63	9	pathogenic	pathogenic	JJ
cord-302082-aaokc182	63	10	virus	virus	NN
cord-302082-aaokc182	63	11	to	to	TO
cord-302082-aaokc182	63	12	carry	carry	VB
cord-302082-aaokc182	63	13	and	and	CC
cord-302082-aaokc182	63	14	subsequently	subsequently	RB
cord-302082-aaokc182	63	15	induce	induce	VB
cord-302082-aaokc182	63	16	expression	expression	NN
cord-302082-aaokc182	63	17	of	of	IN
cord-302082-aaokc182	63	18	genes	gene	NNS
cord-302082-aaokc182	63	19	that	that	WDT
cord-302082-aaokc182	63	20	produce	produce	VBP
cord-302082-aaokc182	63	21	immunogenic	immunogenic	JJ
cord-302082-aaokc182	63	22	foreign	foreign	JJ
cord-302082-aaokc182	63	23	proteins	protein	NNS
cord-302082-aaokc182	63	24	at	at	IN
cord-302082-aaokc182	63	25	high	high	JJ
cord-302082-aaokc182	63	26	levels	level	NNS
cord-302082-aaokc182	63	27	in	in	IN
cord-302082-aaokc182	63	28	the	the	DT
cord-302082-aaokc182	63	29	host	host	NN
cord-302082-aaokc182	63	30	.	.	.
cord-302082-aaokc182	64	1	These	these	DT
cord-302082-aaokc182	64	2	are	be	VBP
cord-302082-aaokc182	64	3	taken	take	VBN
cord-302082-aaokc182	64	4	up	up	RP
cord-302082-aaokc182	64	5	by	by	IN
cord-302082-aaokc182	64	6	immature	immature	JJ
cord-302082-aaokc182	64	7	APCs	apc	NNS
cord-302082-aaokc182	64	8	,	,	,
cord-302082-aaokc182	64	9	and	and	CC
cord-302082-aaokc182	64	10	have	have	VBP
cord-302082-aaokc182	64	11	been	be	VBN
cord-302082-aaokc182	64	12	shown	show	VBN
cord-302082-aaokc182	64	13	to	to	TO
cord-302082-aaokc182	64	14	lead	lead	VB
cord-302082-aaokc182	64	15	to	to	IN
cord-302082-aaokc182	64	16	a	a	DT
cord-302082-aaokc182	64	17	robust	robust	JJ
cord-302082-aaokc182	64	18	,	,	,
cord-302082-aaokc182	64	19	long	long	RB
cord-302082-aaokc182	64	20	-	-	HYPH
cord-302082-aaokc182	64	21	lasting	last	VBG
cord-302082-aaokc182	64	22	immune	immune	JJ
cord-302082-aaokc182	64	23	response	response	NN
cord-302082-aaokc182	64	24	to	to	IN
cord-302082-aaokc182	64	25	the	the	DT
cord-302082-aaokc182	64	26	target	target	NN
cord-302082-aaokc182	64	27	antigen	antigen	NN
cord-302082-aaokc182	64	28	(	(	-LRB-
cord-302082-aaokc182	64	29	Figure	figure	NN
cord-302082-aaokc182	64	30	6	6	CD
cord-302082-aaokc182	64	31	.4	.4	CD
cord-302082-aaokc182	64	32	)	)	-RRB-
cord-302082-aaokc182	64	33	.	.	.
cord-302082-aaokc182	65	1	Viral	viral	JJ
cord-302082-aaokc182	65	2	vector	vector	NN
cord-302082-aaokc182	65	3	vaccines	vaccine	NNS
cord-302082-aaokc182	65	4	,	,	,
cord-302082-aaokc182	65	5	eg	eg	IN
cord-302082-aaokc182	65	6	recombinant	recombinant	JJ
cord-302082-aaokc182	65	7	poxvirus	poxvirus	NNP
cord-302082-aaokc182	65	8	vaccines	vaccine	NNS
cord-302082-aaokc182	65	9	,	,	,
cord-302082-aaokc182	65	10	can	can	MD
cord-302082-aaokc182	65	11	be	be	VB
cord-302082-aaokc182	65	12	administered	administer	VBN
cord-302082-aaokc182	65	13	mucosally	mucosally	RB
cord-302082-aaokc182	65	14	to	to	TO
cord-302082-aaokc182	65	15	stimulate	stimulate	VB
cord-302082-aaokc182	65	16	mucosal	mucosal	JJ
cord-302082-aaokc182	65	17	immune	immune	JJ
cord-302082-aaokc182	65	18	responses	response	NNS
cord-302082-aaokc182	65	19	.	.	.
cord-302082-aaokc182	66	1	The	the	DT
cord-302082-aaokc182	66	2	attenuated	attenuated	JJ
cord-302082-aaokc182	66	3	modified	modified	JJ
cord-302082-aaokc182	66	4	vaccinia	vaccinia	NN
cord-302082-aaokc182	66	5	virus	virus	NN
cord-302082-aaokc182	66	6	Ankara	Ankara	NNP
cord-302082-aaokc182	66	7	(	(	-LRB-
cord-302082-aaokc182	66	8	rMVA	rMVA	NNP
cord-302082-aaokc182	66	9	)	)	-RRB-
cord-302082-aaokc182	66	10	vectors	vector	NNS
cord-302082-aaokc182	66	11	are	be	VBP
cord-302082-aaokc182	66	12	showing	show	VBG
cord-302082-aaokc182	66	13	promise	promise	NN
cord-302082-aaokc182	66	14	as	as	IN
cord-302082-aaokc182	66	15	mucosal	mucosal	JJ
cord-302082-aaokc182	66	16	delivery	delivery	NN
cord-302082-aaokc182	66	17	vectors	vector	NNS
cord-302082-aaokc182	66	18	.	.	.
cord-302082-aaokc182	67	1	Pre	pre	JJ
cord-302082-aaokc182	67	2	-	-	JJ
cord-302082-aaokc182	67	3	existing	existing	JJ
cord-302082-aaokc182	67	4	immunity	immunity	NN
cord-302082-aaokc182	67	5	to	to	IN
cord-302082-aaokc182	67	6	the	the	DT
cord-302082-aaokc182	67	7	viral	viral	JJ
cord-302082-aaokc182	67	8	vaccine	vaccine	NN
cord-302082-aaokc182	67	9	vector	vector	NN
cord-302082-aaokc182	67	10	is	be	VBZ
cord-302082-aaokc182	67	11	an	an	DT
cord-302082-aaokc182	67	12	impediment	impediment	NN
cord-302082-aaokc182	67	13	to	to	IN
cord-302082-aaokc182	67	14	successful	successful	JJ
cord-302082-aaokc182	67	15	use	use	NN
cord-302082-aaokc182	67	16	of	of	IN
cord-302082-aaokc182	67	17	this	this	DT
cord-302082-aaokc182	67	18	approach	approach	NN
cord-302082-aaokc182	67	19	.	.	.
cord-302082-aaokc182	68	1	As	as	IN
cord-302082-aaokc182	68	2	ways	way	NNS
cord-302082-aaokc182	68	3	to	to	TO
cord-302082-aaokc182	68	4	avoid	avoid	VB
cord-302082-aaokc182	68	5	anti	anti	JJ
cord-302082-aaokc182	68	6	-	-	JJ
cord-302082-aaokc182	68	7	vector	vector	JJ
cord-302082-aaokc182	68	8	immunity	immunity	NN
cord-302082-aaokc182	68	9	,	,	,
cord-302082-aaokc182	68	10	viruses	virus	NNS
cord-302082-aaokc182	68	11	can	can	MD
cord-302082-aaokc182	68	12	be	be	VB
cord-302082-aaokc182	68	13	attenuated	attenuate	VBN
cord-302082-aaokc182	68	14	or	or	CC
cord-302082-aaokc182	68	15	inactivated	inactivate	VBN
cord-302082-aaokc182	68	16	,	,	,
cord-302082-aaokc182	68	17	by	by	IN
cord-302082-aaokc182	68	18	deleting	delete	VBG
cord-302082-aaokc182	68	19	or	or	CC
cord-302082-aaokc182	68	20	replacing	replace	VBG
cord-302082-aaokc182	68	21	pathogenic	pathogenic	JJ
cord-302082-aaokc182	68	22	genes	gene	NNS
cord-302082-aaokc182	68	23	.	.	.
cord-302082-aaokc182	69	1	Figure	figure	NN
cord-302082-aaokc182	69	2	6	6	CD
cord-302082-aaokc182	69	3	.4	.4	NN
cord-302082-aaokc182	69	4	demonstrates	demonstrate	VBZ
cord-302082-aaokc182	69	5	how	how	WRB
cord-302082-aaokc182	69	6	viral	viral	JJ
cord-302082-aaokc182	69	7	vaccine	vaccine	NN
cord-302082-aaokc182	69	8	vectors	vector	NNS
cord-302082-aaokc182	69	9	are	be	VBP
cord-302082-aaokc182	69	10	made	make	VBN
cord-302082-aaokc182	69	11	.	.	.
cord-302082-aaokc182	70	1	DNA	DNA	NNP
cord-302082-aaokc182	70	2	expressing	express	VBG
cord-302082-aaokc182	70	3	an	an	DT
cord-302082-aaokc182	70	4	immunogenic	immunogenic	JJ
cord-302082-aaokc182	70	5	transgene	transgene	NN
cord-302082-aaokc182	70	6	(	(	-LRB-
cord-302082-aaokc182	70	7	the	the	DT
cord-302082-aaokc182	70	8	vaccine	vaccine	NN
cord-302082-aaokc182	70	9	antigen	antigen	NN
cord-302082-aaokc182	70	10	)	)	-RRB-
cord-302082-aaokc182	70	11	is	be	VBZ
cord-302082-aaokc182	70	12	inserted	insert	VBN
cord-302082-aaokc182	70	13	into	into	IN
cord-302082-aaokc182	70	14	the	the	DT
cord-302082-aaokc182	70	15	viral	viral	JJ
cord-302082-aaokc182	70	16	vector	vector	NN
cord-302082-aaokc182	70	17	genome	genome	NN
cord-302082-aaokc182	70	18	for	for	IN
cord-302082-aaokc182	70	19	expression	expression	NN
cord-302082-aaokc182	70	20	following	follow	VBG
cord-302082-aaokc182	70	21	administration	administration	NN
cord-302082-aaokc182	70	22	into	into	IN
cord-302082-aaokc182	70	23	the	the	DT
cord-302082-aaokc182	70	24	recipient	recipient	NN
cord-302082-aaokc182	70	25	;	;	:
cord-302082-aaokc182	70	26	expression	expression	NN
cord-302082-aaokc182	70	27	of	of	IN
cord-302082-aaokc182	70	28	the	the	DT
cord-302082-aaokc182	70	29	vaccine	vaccine	NN
cord-302082-aaokc182	70	30	antigen	antigen	NN
cord-302082-aaokc182	70	31	can	can	MD
cord-302082-aaokc182	70	32	be	be	VB
cord-302082-aaokc182	70	33	boosted	boost	VBN
cord-302082-aaokc182	70	34	by	by	IN
cord-302082-aaokc182	70	35	using	use	VBG
cord-302082-aaokc182	70	36	a	a	DT
cord-302082-aaokc182	70	37	variety	variety	NN
cord-302082-aaokc182	70	38	of	of	IN
cord-302082-aaokc182	70	39	DNA	dna	NN
cord-302082-aaokc182	70	40	promoters	promoter	NNS
cord-302082-aaokc182	70	41	.	.	.
cord-302082-aaokc182	71	1	If	if	IN
cord-302082-aaokc182	71	2	the	the	DT
cord-302082-aaokc182	71	3	viral	viral	JJ
cord-302082-aaokc182	71	4	vector	vector	NN
cord-302082-aaokc182	71	5	is	be	VBZ
cord-302082-aaokc182	71	6	no	no	DT
cord-302082-aaokc182	71	7	longer	longer	RB
cord-302082-aaokc182	71	8	able	able	JJ
cord-302082-aaokc182	71	9	to	to	TO
cord-302082-aaokc182	71	10	grow	grow	VB
cord-302082-aaokc182	71	11	and	and	CC
cord-302082-aaokc182	71	12	replicate	replicate	VB
cord-302082-aaokc182	71	13	,	,	,
cord-302082-aaokc182	71	14	the	the	DT
cord-302082-aaokc182	71	15	virus	virus	NN
cord-302082-aaokc182	71	16	is	be	VBZ
cord-302082-aaokc182	71	17	grown	grow	VBN
cord-302082-aaokc182	71	18	using	use	VBG
cord-302082-aaokc182	71	19	a	a	DT
cord-302082-aaokc182	71	20	cell	cell	NN
cord-302082-aaokc182	71	21	line	line	NN
cord-302082-aaokc182	71	22	(	(	-LRB-
cord-302082-aaokc182	71	23	a	a	DT
cord-302082-aaokc182	71	24	so	so	RB
cord-302082-aaokc182	71	25	-	-	HYPH
cord-302082-aaokc182	71	26	called	call	VBN
cord-302082-aaokc182	71	27	complementing	complement	VBG
cord-302082-aaokc182	71	28	cell	cell	NN
cord-302082-aaokc182	71	29	line	line	NN
cord-302082-aaokc182	71	30	)	)	-RRB-
cord-302082-aaokc182	71	31	that	that	WDT
cord-302082-aaokc182	71	32	has	have	VBZ
cord-302082-aaokc182	71	33	been	be	VBN
cord-302082-aaokc182	71	34	engineered	engineer	VBN
cord-302082-aaokc182	71	35	to	to	TO
cord-302082-aaokc182	71	36	produce	produce	VB
cord-302082-aaokc182	71	37	the	the	DT
cord-302082-aaokc182	71	38	missing	miss	VBG
cord-302082-aaokc182	71	39	viral	viral	JJ
cord-302082-aaokc182	71	40	product	product	NN
cord-302082-aaokc182	71	41	.	.	.
cord-302082-aaokc182	72	1	Often	often	RB
cord-302082-aaokc182	72	2	,	,	,
cord-302082-aaokc182	72	3	viral	viral	JJ
cord-302082-aaokc182	72	4	genes	gene	NNS
cord-302082-aaokc182	72	5	are	be	VBP
cord-302082-aaokc182	72	6	removed	remove	VBN
cord-302082-aaokc182	72	7	in	in	IN
cord-302082-aaokc182	72	8	an	an	DT
cord-302082-aaokc182	72	9	effort	effort	NN
cord-302082-aaokc182	72	10	to	to	TO
cord-302082-aaokc182	72	11	reduce	reduce	VB
cord-302082-aaokc182	72	12	or	or	CC
cord-302082-aaokc182	72	13	eliminate	eliminate	VB
cord-302082-aaokc182	72	14	the	the	DT
cord-302082-aaokc182	72	15	pathogenicity	pathogenicity	NN
cord-302082-aaokc182	72	16	of	of	IN
cord-302082-aaokc182	72	17	the	the	DT
cord-302082-aaokc182	72	18	vector	vector	NN
cord-302082-aaokc182	72	19	and	and	CC
cord-302082-aaokc182	72	20	in	in	IN
cord-302082-aaokc182	72	21	some	some	DT
cord-302082-aaokc182	72	22	cases	case	NNS
cord-302082-aaokc182	72	23	viral	viral	JJ
cord-302082-aaokc182	72	24	genes	gene	NNS
cord-302082-aaokc182	72	25	are	be	VBP
cord-302082-aaokc182	72	26	removed	remove	VBN
cord-302082-aaokc182	72	27	to	to	TO
cord-302082-aaokc182	72	28	make	make	VB
cord-302082-aaokc182	72	29	the	the	DT
cord-302082-aaokc182	72	30	vector	vector	NN
cord-302082-aaokc182	72	31	itself	-PRON-	PRP
cord-302082-aaokc182	72	32	less	less	RBR
cord-302082-aaokc182	72	33	immunogenic	immunogenic	JJ
cord-302082-aaokc182	72	34	;	;	:
cord-302082-aaokc182	72	35	an	an	DT
cord-302082-aaokc182	72	36	anti	anti	JJ
cord-302082-aaokc182	72	37	-	-	JJ
cord-302082-aaokc182	72	38	vector	vector	JJ
cord-302082-aaokc182	72	39	immune	immune	JJ
cord-302082-aaokc182	72	40	response	response	NN
cord-302082-aaokc182	72	41	would	would	MD
cord-302082-aaokc182	72	42	greatly	greatly	RB
cord-302082-aaokc182	72	43	reduce	reduce	VB
cord-302082-aaokc182	72	44	the	the	DT
cord-302082-aaokc182	72	45	ability	ability	NN
cord-302082-aaokc182	72	46	of	of	IN
cord-302082-aaokc182	72	47	the	the	DT
cord-302082-aaokc182	72	48	vector	vector	NN
cord-302082-aaokc182	72	49	to	to	TO
cord-302082-aaokc182	72	50	induce	induce	VB
cord-302082-aaokc182	72	51	an	an	DT
cord-302082-aaokc182	72	52	antigen	antigen	NN
cord-302082-aaokc182	72	53	-	-	HYPH
cord-302082-aaokc182	72	54	specific	specific	JJ
cord-302082-aaokc182	72	55	response	response	NN
cord-302082-aaokc182	72	56	.	.	.
cord-302082-aaokc182	73	1	Examples	example	NNS
cord-302082-aaokc182	73	2	of	of	IN
cord-302082-aaokc182	73	3	viral	viral	JJ
cord-302082-aaokc182	73	4	vector	vector	NN
cord-302082-aaokc182	73	5	candidate	candidate	NN
cord-302082-aaokc182	73	6	vaccines	vaccine	NNS
cord-302082-aaokc182	73	7	in	in	IN
cord-302082-aaokc182	73	8	clinical	clinical	JJ
cord-302082-aaokc182	73	9	development	development	NN
cord-302082-aaokc182	73	10	are	be	VBP
cord-302082-aaokc182	73	11	listed	list	VBN
cord-302082-aaokc182	73	12	in	in	IN
cord-302082-aaokc182	73	13	Table	Table	NNP
cord-302082-aaokc182	73	14	6	6	CD
cord-302082-aaokc182	73	15	.3	.3	NFP
cord-302082-aaokc182	73	16	.	.	.
cord-302082-aaokc182	74	1	Non	non	JJ
cord-302082-aaokc182	74	2	-	-	JJ
cord-302082-aaokc182	74	3	pathogenic	pathogenic	JJ
cord-302082-aaokc182	74	4	bacterial	bacterial	JJ
cord-302082-aaokc182	74	5	vectors	vector	NNS
cord-302082-aaokc182	74	6	have	have	VBP
cord-302082-aaokc182	74	7	many	many	JJ
cord-302082-aaokc182	74	8	features	feature	NNS
cord-302082-aaokc182	74	9	that	that	WDT
cord-302082-aaokc182	74	10	make	make	VBP
cord-302082-aaokc182	74	11	them	-PRON-	PRP
cord-302082-aaokc182	74	12	an	an	DT
cord-302082-aaokc182	74	13	attractive	attractive	JJ
cord-302082-aaokc182	74	14	vaccine	vaccine	NN
cord-302082-aaokc182	74	15	platform	platform	NN
cord-302082-aaokc182	74	16	.	.	.
cord-302082-aaokc182	75	1	Bacterial	bacterial	JJ
cord-302082-aaokc182	75	2	vectors	vector	NNS
cord-302082-aaokc182	75	3	can	can	MD
cord-302082-aaokc182	75	4	be	be	VB
cord-302082-aaokc182	75	5	engineered	engineer	VBN
cord-302082-aaokc182	75	6	for	for	IN
cord-302082-aaokc182	75	7	maximum	maximum	JJ
cord-302082-aaokc182	75	8	safety	safety	NN
cord-302082-aaokc182	75	9	(	(	-LRB-
cord-302082-aaokc182	75	10	eg	eg	IN
cord-302082-aaokc182	75	11	deletion	deletion	NN
cord-302082-aaokc182	75	12	of	of	IN
cord-302082-aaokc182	75	13	two	two	CD
cord-302082-aaokc182	75	14	or	or	CC
cord-302082-aaokc182	75	15	more	more	JJR
cord-302082-aaokc182	75	16	genes	gene	NNS
cord-302082-aaokc182	75	17	from	from	IN
cord-302082-aaokc182	75	18	the	the	DT
cord-302082-aaokc182	75	19	same	same	JJ
cord-302082-aaokc182	75	20	metabolic	metabolic	JJ
cord-302082-aaokc182	75	21	pathway	pathway	NN
cord-302082-aaokc182	75	22	)	)	-RRB-
cord-302082-aaokc182	75	23	,	,	,
cord-302082-aaokc182	75	24	and	and	CC
cord-302082-aaokc182	75	25	to	to	TO
cord-302082-aaokc182	75	26	express	express	VB
cord-302082-aaokc182	75	27	large	large	JJ
cord-302082-aaokc182	75	28	numbers	number	NNS
cord-302082-aaokc182	75	29	of	of	IN
cord-302082-aaokc182	75	30	foreign	foreign	JJ
cord-302082-aaokc182	75	31	antigens	antigen	NNS
cord-302082-aaokc182	75	32	(	(	-LRB-
cord-302082-aaokc182	75	33	Figure	figure	NN
cord-302082-aaokc182	75	34	6	6	CD
cord-302082-aaokc182	75	35	.5	.5	CD
cord-302082-aaokc182	75	36	)	)	-RRB-
cord-302082-aaokc182	75	37	.	.	.
cord-302082-aaokc182	76	1	Two	two	CD
cord-302082-aaokc182	76	2	key	key	JJ
cord-302082-aaokc182	76	3	issues	issue	NNS
cord-302082-aaokc182	76	4	affecting	affect	VBG
cord-302082-aaokc182	76	5	bacterial	bacterial	JJ
cord-302082-aaokc182	76	6	vaccine	vaccine	NN
cord-302082-aaokc182	76	7	vectors	vector	NNS
cord-302082-aaokc182	76	8	are	be	VBP
cord-302082-aaokc182	76	9	:	:	:
cord-302082-aaokc182	76	10	a	a	LS
cord-302082-aaokc182	76	11	)	)	-RRB-
cord-302082-aaokc182	76	12	to	to	TO
cord-302082-aaokc182	76	13	decide	decide	VB
cord-302082-aaokc182	76	14	whether	whether	IN
cord-302082-aaokc182	76	15	the	the	DT
cord-302082-aaokc182	76	16	optimal	optimal	JJ
cord-302082-aaokc182	76	17	platform	platform	NN
cord-302082-aaokc182	76	18	should	should	MD
cord-302082-aaokc182	76	19	be	be	VB
cord-302082-aaokc182	76	20	a	a	DT
cord-302082-aaokc182	76	21	bacterial	bacterial	JJ
cord-302082-aaokc182	76	22	vaccine	vaccine	NN
cord-302082-aaokc182	76	23	in	in	IN
cord-302082-aaokc182	76	24	its	-PRON-	PRP$
cord-302082-aaokc182	76	25	Figure	figure	NN
cord-302082-aaokc182	76	26	6	6	CD
cord-302082-aaokc182	76	27	.4	.4	CD
cord-302082-aaokc182	76	28	Viral	viral	JJ
cord-302082-aaokc182	76	29	vectors	vector	NNS
cord-302082-aaokc182	76	30	for	for	IN
cord-302082-aaokc182	76	31	vaccines	vaccine	NNS
cord-302082-aaokc182	76	32	.	.	.
cord-302082-aaokc182	77	1	Viral	viral	JJ
cord-302082-aaokc182	77	2	vector	vector	NN
cord-302082-aaokc182	77	3	vaccines	vaccine	NNS
cord-302082-aaokc182	77	4	exploit	exploit	VBP
cord-302082-aaokc182	77	5	the	the	DT
cord-302082-aaokc182	77	6	natural	natural	JJ
cord-302082-aaokc182	77	7	ability	ability	NN
cord-302082-aaokc182	77	8	of	of	IN
cord-302082-aaokc182	77	9	viruses	virus	NNS
cord-302082-aaokc182	77	10	to	to	TO
cord-302082-aaokc182	77	11	infect	infect	VB
cord-302082-aaokc182	77	12	or	or	CC
cord-302082-aaokc182	77	13	otherwise	otherwise	RB
cord-302082-aaokc182	77	14	enter	enter	VB
cord-302082-aaokc182	77	15	(	(	-LRB-
cord-302082-aaokc182	77	16	in	in	IN
cord-302082-aaokc182	77	17	the	the	DT
cord-302082-aaokc182	77	18	case	case	NN
cord-302082-aaokc182	77	19	of	of	IN
cord-302082-aaokc182	77	20	disabled	disabled	JJ
cord-302082-aaokc182	77	21	viral	viral	JJ
cord-302082-aaokc182	77	22	vectors	vector	NNS
cord-302082-aaokc182	77	23	)	)	-RRB-
cord-302082-aaokc182	77	24	host	host	NN
cord-302082-aaokc182	77	25	cells	cell	NNS
cord-302082-aaokc182	77	26	,	,	,
cord-302082-aaokc182	77	27	and	and	CC
cord-302082-aaokc182	77	28	then	then	RB
cord-302082-aaokc182	77	29	deliver	deliver	VB
cord-302082-aaokc182	77	30	pathogen	pathogen	NN
cord-302082-aaokc182	77	31	-	-	HYPH
cord-302082-aaokc182	77	32	specific	specific	JJ
cord-302082-aaokc182	77	33	antigens	antigen	NNS
cord-302082-aaokc182	77	34	.	.	.
cord-302082-aaokc182	78	1	Antigen	antigen	NN
cord-302082-aaokc182	78	2	-	-	HYPH
cord-302082-aaokc182	78	3	encoding	encode	VBG
cord-302082-aaokc182	78	4	genes	gene	NNS
cord-302082-aaokc182	78	5	are	be	VBP
cord-302082-aaokc182	78	6	isolated	isolate	VBN
cord-302082-aaokc182	78	7	from	from	IN
cord-302082-aaokc182	78	8	the	the	DT
cord-302082-aaokc182	78	9	pathogen	pathogen	NN
cord-302082-aaokc182	78	10	and	and	CC
cord-302082-aaokc182	78	11	inserted	insert	VBD
cord-302082-aaokc182	78	12	into	into	IN
cord-302082-aaokc182	78	13	the	the	DT
cord-302082-aaokc182	78	14	viral	viral	JJ
cord-302082-aaokc182	78	15	vector	vector	NN
cord-302082-aaokc182	78	16	genome	genome	NN
cord-302082-aaokc182	78	17	.	.	.
cord-302082-aaokc182	79	1	The	the	DT
cord-302082-aaokc182	79	2	viral	viral	JJ
cord-302082-aaokc182	79	3	vector	vector	NN
cord-302082-aaokc182	79	4	can	can	MD
cord-302082-aaokc182	79	5	then	then	RB
cord-302082-aaokc182	79	6	be	be	VB
cord-302082-aaokc182	79	7	used	use	VBN
cord-302082-aaokc182	79	8	as	as	IN
cord-302082-aaokc182	79	9	a	a	DT
cord-302082-aaokc182	79	10	factory	factory	NN
cord-302082-aaokc182	79	11	for	for	IN
cord-302082-aaokc182	79	12	production	production	NN
cord-302082-aaokc182	79	13	of	of	IN
cord-302082-aaokc182	79	14	large	large	JJ
cord-302082-aaokc182	79	15	quantities	quantity	NNS
cord-302082-aaokc182	79	16	of	of	IN
cord-302082-aaokc182	79	17	pathogen	pathogen	NN
cord-302082-aaokc182	79	18	antigen	antigen	NN
cord-302082-aaokc182	79	19	in	in	IN
cord-302082-aaokc182	79	20	vivo	vivo	NN
cord-302082-aaokc182	79	21	,	,	,
cord-302082-aaokc182	79	22	following	follow	VBG
cord-302082-aaokc182	79	23	introduction	introduction	NN
cord-302082-aaokc182	79	24	of	of	IN
cord-302082-aaokc182	79	25	the	the	DT
cord-302082-aaokc182	79	26	vector	vector	NN
cord-302082-aaokc182	79	27	into	into	IN
cord-302082-aaokc182	79	28	the	the	DT
cord-302082-aaokc182	79	29	vaccine	vaccine	NN
cord-302082-aaokc182	79	30	recipient	recipient	NN
cord-302082-aaokc182	79	31	,	,	,
cord-302082-aaokc182	79	32	with	with	IN
cord-302082-aaokc182	79	33	the	the	DT
cord-302082-aaokc182	79	34	pathogen	pathogen	NN
cord-302082-aaokc182	79	35	antigen	antigen	NN
cord-302082-aaokc182	79	36	then	then	RB
cord-302082-aaokc182	79	37	expressed	express	VBD
cord-302082-aaokc182	79	38	on	on	IN
cord-302082-aaokc182	79	39	the	the	DT
cord-302082-aaokc182	79	40	surface	surface	NN
cord-302082-aaokc182	79	41	of	of	IN
cord-302082-aaokc182	79	42	the	the	DT
cord-302082-aaokc182	79	43	infected	infect	VBN
cord-302082-aaokc182	79	44	/	/	SYM
cord-302082-aaokc182	79	45	transduced	transduce	VBN
cord-302082-aaokc182	79	46	host	host	NN
cord-302082-aaokc182	79	47	cells	cell	NNS
cord-302082-aaokc182	79	48	or	or	CC
cord-302082-aaokc182	79	49	exported	export	VBN
cord-302082-aaokc182	79	50	out	out	IN
cord-302082-aaokc182	79	51	of	of	IN
cord-302082-aaokc182	79	52	the	the	DT
cord-302082-aaokc182	79	53	producer	producer	NN
cord-302082-aaokc182	79	54	cell	cell	NN
cord-302082-aaokc182	79	55	.	.	.
cord-302082-aaokc182	80	1	MHC	MHC	NNP
cord-302082-aaokc182	80	2	,	,	,
cord-302082-aaokc182	80	3	major	major	JJ
cord-302082-aaokc182	80	4	histocompatibility	histocompatibility	NN
cord-302082-aaokc182	80	5	complex	complex	NN
cord-302082-aaokc182	80	6	.	.	.
cord-302082-aaokc182	81	1	own	own	JJ
cord-302082-aaokc182	81	2	right	right	NN
cord-302082-aaokc182	81	3	or	or	CC
cord-302082-aaokc182	81	4	a	a	DT
cord-302082-aaokc182	81	5	bacterial	bacterial	JJ
cord-302082-aaokc182	81	6	vector	vector	NN
cord-302082-aaokc182	81	7	system	system	NN
cord-302082-aaokc182	81	8	to	to	TO
cord-302082-aaokc182	81	9	deliver	deliver	VB
cord-302082-aaokc182	81	10	exogenous	exogenous	JJ
cord-302082-aaokc182	81	11	antigens	antigen	NNS
cord-302082-aaokc182	81	12	;	;	:
cord-302082-aaokc182	81	13	and	and	CC
cord-302082-aaokc182	81	14	b	b	LS
cord-302082-aaokc182	81	15	)	)	-RRB-
cord-302082-aaokc182	82	1	to	to	TO
cord-302082-aaokc182	82	2	determine	determine	VB
cord-302082-aaokc182	82	3	whether	whether	IN
cord-302082-aaokc182	82	4	re	re	NN
cord-302082-aaokc182	82	5	-	-	NN
cord-302082-aaokc182	82	6	administration	administration	NN
cord-302082-aaokc182	82	7	of	of	IN
cord-302082-aaokc182	82	8	the	the	DT
cord-302082-aaokc182	82	9	vector	vector	NN
cord-302082-aaokc182	82	10	,	,	,
cord-302082-aaokc182	82	11	either	either	CC
cord-302082-aaokc182	82	12	with	with	IN
cord-302082-aaokc182	82	13	the	the	DT
cord-302082-aaokc182	82	14	same	same	JJ
cord-302082-aaokc182	82	15	or	or	CC
cord-302082-aaokc182	82	16	different	different	JJ
cord-302082-aaokc182	82	17	target	target	NN
cord-302082-aaokc182	82	18	antigens	antigen	NNS
cord-302082-aaokc182	82	19	,	,	,
cord-302082-aaokc182	82	20	will	will	MD
cord-302082-aaokc182	82	21	fail	fail	VB
cord-302082-aaokc182	82	22	because	because	IN
cord-302082-aaokc182	82	23	of	of	IN
cord-302082-aaokc182	82	24	the	the	DT
cord-302082-aaokc182	82	25	immune	immune	JJ
cord-302082-aaokc182	82	26	response	response	NN
cord-302082-aaokc182	82	27	to	to	IN
cord-302082-aaokc182	82	28	the	the	DT
cord-302082-aaokc182	82	29	bacterial	bacterial	JJ
cord-302082-aaokc182	82	30	vector	vector	NN
cord-302082-aaokc182	82	31	vaccine	vaccine	NN
cord-302082-aaokc182	82	32	at	at	IN
cord-302082-aaokc182	82	33	the	the	DT
cord-302082-aaokc182	82	34	time	time	NN
cord-302082-aaokc182	82	35	of	of	IN
cord-302082-aaokc182	82	36	its	-PRON-	PRP$
cord-302082-aaokc182	82	37	initial	initial	JJ
cord-302082-aaokc182	82	38	administration	administration	NN
cord-302082-aaokc182	82	39	.	.	.
cord-302082-aaokc182	83	1	Initial	initial	JJ
cord-302082-aaokc182	83	2	assessments	assessment	NNS
cord-302082-aaokc182	83	3	of	of	IN
cord-302082-aaokc182	83	4	the	the	DT
cord-302082-aaokc182	83	5	feasibility	feasibility	NN
cord-302082-aaokc182	83	6	of	of	IN
cord-302082-aaokc182	83	7	using	use	VBG
cord-302082-aaokc182	83	8	attenuated	attenuated	JJ
cord-302082-aaokc182	83	9	bacterial	bacterial	JJ
cord-302082-aaokc182	83	10	vectors	vector	NNS
cord-302082-aaokc182	83	11	for	for	IN
cord-302082-aaokc182	83	12	the	the	DT
cord-302082-aaokc182	83	13	delivery	delivery	NN
cord-302082-aaokc182	83	14	of	of	IN
cord-302082-aaokc182	83	15	foreign	foreign	JJ
cord-302082-aaokc182	83	16	antigens	antigen	NNS
cord-302082-aaokc182	83	17	have	have	VBP
cord-302082-aaokc182	83	18	focused	focus	VBN
cord-302082-aaokc182	83	19	on	on	IN
cord-302082-aaokc182	83	20	Salmonella	Salmonella	NNP
cord-302082-aaokc182	83	21	species	specie	NNS
cord-302082-aaokc182	83	22	.	.	.
cord-302082-aaokc182	84	1	Bacterial	bacterial	JJ
cord-302082-aaokc182	84	2	vaccine	vaccine	NN
cord-302082-aaokc182	84	3	vectors	vector	NNS
cord-302082-aaokc182	84	4	for	for	IN
cord-302082-aaokc182	84	5	humans	human	NNS
cord-302082-aaokc182	84	6	,	,	,
cord-302082-aaokc182	84	7	however	however	RB
cord-302082-aaokc182	84	8	,	,	,
cord-302082-aaokc182	84	9	have	have	VBP
cord-302082-aaokc182	84	10	been	be	VBN
cord-302082-aaokc182	84	11	disappointing	disappointing	JJ
cord-302082-aaokc182	84	12	so	so	RB
cord-302082-aaokc182	84	13	far	far	RB
cord-302082-aaokc182	84	14	.	.	.
cord-302082-aaokc182	85	1	It	-PRON-	PRP
cord-302082-aaokc182	85	2	may	may	MD
cord-302082-aaokc182	85	3	be	be	VB
cord-302082-aaokc182	85	4	necessary	necessary	JJ
cord-302082-aaokc182	85	5	to	to	TO
cord-302082-aaokc182	85	6	develop	develop	VB
cord-302082-aaokc182	85	7	unique	unique	JJ
cord-302082-aaokc182	85	8	bacterial	bacterial	JJ
cord-302082-aaokc182	85	9	vaccine	vaccine	NN
cord-302082-aaokc182	85	10	vectors	vector	NNS
cord-302082-aaokc182	85	11	for	for	IN
cord-302082-aaokc182	85	12	delivering	deliver	VBG
cord-302082-aaokc182	85	13	exogenous	exogenous	JJ
cord-302082-aaokc182	85	14	antigens	antigen	NNS
cord-302082-aaokc182	85	15	,	,	,
cord-302082-aaokc182	85	16	in	in	IN
cord-302082-aaokc182	85	17	which	which	WDT
cord-302082-aaokc182	85	18	case	case	NN
cord-302082-aaokc182	85	19	the	the	DT
cord-302082-aaokc182	85	20	vectors	vector	NNS
cord-302082-aaokc182	85	21	can	can	MD
cord-302082-aaokc182	85	22	be	be	VB
cord-302082-aaokc182	85	23	modified	modify	VBN
cord-302082-aaokc182	85	24	to	to	TO
cord-302082-aaokc182	85	25	allow	allow	VB
cord-302082-aaokc182	85	26	for	for	IN
cord-302082-aaokc182	85	27	re	re	NN
cord-302082-aaokc182	85	28	-	-	NN
cord-302082-aaokc182	85	29	use	use	NN
cord-302082-aaokc182	85	30	.	.	.
cord-302082-aaokc182	86	1	For	for	IN
cord-302082-aaokc182	86	2	example	example	NN
cord-302082-aaokc182	86	3	,	,	,
cord-302082-aaokc182	86	4	if	if	IN
cord-302082-aaokc182	86	5	immunity	immunity	NN
cord-302082-aaokc182	86	6	against	against	IN
cord-302082-aaokc182	86	7	the	the	DT
cord-302082-aaokc182	86	8	vector	vector	NN
cord-302082-aaokc182	86	9	,	,	,
cord-302082-aaokc182	86	10	which	which	WDT
cord-302082-aaokc182	86	11	is	be	VBZ
cord-302082-aaokc182	86	12	a	a	DT
cord-302082-aaokc182	86	13	major	major	JJ
cord-302082-aaokc182	86	14	impediment	impediment	NN
cord-302082-aaokc182	86	15	to	to	IN
cord-302082-aaokc182	86	16	vaccine	vaccine	NN
cord-302082-aaokc182	86	17	re	re	NNS
cord-302082-aaokc182	86	18	-	-	NN
cord-302082-aaokc182	86	19	use	use	NN
cord-302082-aaokc182	86	20	,	,	,
cord-302082-aaokc182	86	21	is	be	VBZ
cord-302082-aaokc182	86	22	determined	determine	VBN
cord-302082-aaokc182	86	23	by	by	IN
cord-302082-aaokc182	86	24	antibodies	antibody	NNS
cord-302082-aaokc182	86	25	against	against	IN
cord-302082-aaokc182	86	26	the	the	DT
cord-302082-aaokc182	86	27	surface	surface	NN
cord-302082-aaokc182	86	28	structures	structure	NNS
cord-302082-aaokc182	86	29	of	of	IN
cord-302082-aaokc182	86	30	the	the	DT
cord-302082-aaokc182	86	31	bacterium	bacterium	NN
cord-302082-aaokc182	86	32	(	(	-LRB-
cord-302082-aaokc182	86	33	such	such	JJ
cord-302082-aaokc182	86	34	as	as	IN
cord-302082-aaokc182	86	35	lipopolysaccharide	lipopolysaccharide	NN
cord-302082-aaokc182	86	36	[	[	-LRB-
cord-302082-aaokc182	86	37	LPS	LPS	NNP
cord-302082-aaokc182	86	38	]	]	-RRB-
cord-302082-aaokc182	86	39	)	)	-RRB-
cord-302082-aaokc182	86	40	,	,	,
cord-302082-aaokc182	86	41	the	the	DT
cord-302082-aaokc182	86	42	dedicated	dedicated	JJ
cord-302082-aaokc182	86	43	vaccine	vaccine	NN
cord-302082-aaokc182	86	44	vector	vector	NN
cord-302082-aaokc182	86	45	could	could	MD
cord-302082-aaokc182	86	46	be	be	VB
cord-302082-aaokc182	86	47	developed	develop	VBN
cord-302082-aaokc182	86	48	to	to	TO
cord-302082-aaokc182	86	49	lack	lack	VB
cord-302082-aaokc182	86	50	expression	expression	NN
cord-302082-aaokc182	86	51	of	of	IN
cord-302082-aaokc182	86	52	LPS	LPS	NNP
cord-302082-aaokc182	86	53	or	or	CC
cord-302082-aaokc182	86	54	to	to	TO
cord-302082-aaokc182	86	55	express	express	VB
cord-302082-aaokc182	86	56	truncated/	truncated/	JJ
cord-302082-aaokc182	86	57	different	different	JJ
cord-302082-aaokc182	86	58	forms	form	NNS
cord-302082-aaokc182	86	59	of	of	IN
cord-302082-aaokc182	86	60	LPS	lp	NNS
cord-302082-aaokc182	86	61	to	to	IN
cord-302082-aaokc182	86	62	the	the	DT
cord-302082-aaokc182	86	63	target	target	NN
cord-302082-aaokc182	86	64	,	,	,
cord-302082-aaokc182	86	65	thereby	thereby	RB
cord-302082-aaokc182	86	66	avoiding	avoid	VBG
cord-302082-aaokc182	86	67	priming	priming	NN
cord-302082-aaokc182	86	68	of	of	IN
cord-302082-aaokc182	86	69	the	the	DT
cord-302082-aaokc182	86	70	immune	immune	JJ
cord-302082-aaokc182	86	71	response	response	NN
cord-302082-aaokc182	86	72	and	and	CC
cord-302082-aaokc182	86	73	allowing	allow	VBG
cord-302082-aaokc182	86	74	for	for	IN
cord-302082-aaokc182	86	75	re	re	NN
cord-302082-aaokc182	86	76	-	-	NN
cord-302082-aaokc182	86	77	use	use	NN
cord-302082-aaokc182	86	78	of	of	IN
cord-302082-aaokc182	86	79	the	the	DT
cord-302082-aaokc182	86	80	vector	vector	NN
cord-302082-aaokc182	86	81	and/or	and/or	CC
cord-302082-aaokc182	86	82	vaccine	vaccine	NN
cord-302082-aaokc182	86	83	.	.	.
cord-302082-aaokc182	87	1	Some	some	DT
cord-302082-aaokc182	87	2	potential	potential	JJ
cord-302082-aaokc182	87	3	options	option	NNS
cord-302082-aaokc182	87	4	for	for	IN
cord-302082-aaokc182	87	5	live	live	JJ
cord-302082-aaokc182	87	6	,	,	,
cord-302082-aaokc182	87	7	attenuated	attenuated	JJ
cord-302082-aaokc182	87	8	bacterial	bacterial	JJ
cord-302082-aaokc182	87	9	vectors	vector	NNS
cord-302082-aaokc182	87	10	are	be	VBP
cord-302082-aaokc182	87	11	shown	show	VBN
cord-302082-aaokc182	87	12	in	in	IN
cord-302082-aaokc182	87	13	Table	Table	NNP
cord-302082-aaokc182	87	14	6	6	CD
cord-302082-aaokc182	87	15	.4	.4	CD
cord-302082-aaokc182	87	16	.	.	.
cord-302082-aaokc182	87	17	 	 	_SP
cord-302082-aaokc182	88	1	DNA	DNA	NNP
cord-302082-aaokc182	88	2	vaccines	vaccine	NNS
cord-302082-aaokc182	88	3	are	be	VBP
cord-302082-aaokc182	88	4	the	the	DT
cord-302082-aaokc182	88	5	result	result	NN
cord-302082-aaokc182	88	6	of	of	IN
cord-302082-aaokc182	88	7	the	the	DT
cord-302082-aaokc182	88	8	discovery	discovery	NN
cord-302082-aaokc182	88	9	in	in	IN
cord-302082-aaokc182	88	10	the	the	DT
cord-302082-aaokc182	88	11	early	early	JJ
cord-302082-aaokc182	88	12	1990s	1990	NNS
cord-302082-aaokc182	88	13	that	that	IN
cord-302082-aaokc182	88	14	the	the	DT
cord-302082-aaokc182	88	15	gene	gene	NN
cord-302082-aaokc182	88	16	,	,	,
cord-302082-aaokc182	88	17	rather	rather	RB
cord-302082-aaokc182	88	18	than	than	IN
cord-302082-aaokc182	88	19	the	the	DT
cord-302082-aaokc182	88	20	encoded	encode	VBN
cord-302082-aaokc182	88	21	protein	protein	NN
cord-302082-aaokc182	88	22	,	,	,
cord-302082-aaokc182	88	23	if	if	IN
cord-302082-aaokc182	88	24	delivered	deliver	VBN
cord-302082-aaokc182	88	25	in	in	IN
cord-302082-aaokc182	88	26	an	an	DT
cord-302082-aaokc182	88	27	'	'	``
cord-302082-aaokc182	88	28	expressible	expressible	JJ
cord-302082-aaokc182	88	29	'	'	''
cord-302082-aaokc182	88	30	form	form	NN
cord-302082-aaokc182	88	31	,	,	,
cord-302082-aaokc182	88	32	could	could	MD
cord-302082-aaokc182	88	33	induce	induce	VB
cord-302082-aaokc182	88	34	an	an	DT
cord-302082-aaokc182	88	35	immune	immune	JJ
cord-302082-aaokc182	88	36	response	response	NN
cord-302082-aaokc182	88	37	(	(	-LRB-
cord-302082-aaokc182	88	38	see	see	VB
cord-302082-aaokc182	88	39	Chapter	chapter	NN
cord-302082-aaokc182	88	40	1	1	CD
cord-302082-aaokc182	88	41	e	e	NN
cord-302082-aaokc182	88	42	Vaccine	vaccine	NN
cord-302082-aaokc182	88	43	evolution	evolution	NN
cord-302082-aaokc182	88	44	)	)	-RRB-
cord-302082-aaokc182	88	45	.	.	.
cord-302082-aaokc182	89	1	The	the	DT
cord-302082-aaokc182	89	2	principle	principle	NN
cord-302082-aaokc182	89	3	behind	behind	IN
cord-302082-aaokc182	89	4	DNA	dna	NN
cord-302082-aaokc182	89	5	vaccines	vaccine	NNS
cord-302082-aaokc182	89	6	is	be	VBZ
cord-302082-aaokc182	89	7	that	that	IN
cord-302082-aaokc182	89	8	the	the	DT
cord-302082-aaokc182	89	9	antigenic	antigenic	JJ
cord-302082-aaokc182	89	10	molecule	molecule	NN
cord-302082-aaokc182	89	11	is	be	VBZ
cord-302082-aaokc182	89	12	produced	produce	VBN
cord-302082-aaokc182	89	13	within	within	IN
cord-302082-aaokc182	89	14	the	the	DT
cord-302082-aaokc182	89	15	host	host	NN
cord-302082-aaokc182	89	16	from	from	IN
cord-302082-aaokc182	89	17	the	the	DT
cord-302082-aaokc182	89	18	DNA	DNA	NNP
cord-302082-aaokc182	89	19	or	or	CC
cord-302082-aaokc182	89	20	RNA	RNA	NNP
cord-302082-aaokc182	89	21	that	that	WDT
cord-302082-aaokc182	89	22	is	be	VBZ
cord-302082-aaokc182	89	23	injected	inject	VBN
cord-302082-aaokc182	89	24	,	,	,
cord-302082-aaokc182	89	25	in	in	IN
cord-302082-aaokc182	89	26	contrast	contrast	NN
cord-302082-aaokc182	89	27	to	to	IN
cord-302082-aaokc182	89	28	more	more	JJR
cord-302082-aaokc182	89	29	traditional	traditional	JJ
cord-302082-aaokc182	89	30	vaccination	vaccination	NN
cord-302082-aaokc182	89	31	where	where	WRB
cord-302082-aaokc182	89	32	the	the	DT
cord-302082-aaokc182	89	33	antigen	antigen	NN
cord-302082-aaokc182	89	34	is	be	VBZ
cord-302082-aaokc182	89	35	supplied	supply	VBN
cord-302082-aaokc182	89	36	in	in	IN
cord-302082-aaokc182	89	37	the	the	DT
cord-302082-aaokc182	89	38	vaccine	vaccine	NN
cord-302082-aaokc182	89	39	formulation	formulation	NN
cord-302082-aaokc182	89	40	.	.	.
cord-302082-aaokc182	90	1	The	the	DT
cord-302082-aaokc182	90	2	gene(s	gene(s	NNP
cord-302082-aaokc182	90	3	)	)	-RRB-
cord-302082-aaokc182	90	4	for	for	IN
cord-302082-aaokc182	90	5	target	target	NN
cord-302082-aaokc182	90	6	antigen(s	antigen(s	NNP
cord-302082-aaokc182	90	7	)	)	-RRB-
cord-302082-aaokc182	90	8	is	be	VBZ
cord-302082-aaokc182	90	9	/	/	,
cord-302082-aaokc182	90	10	are	be	VBP
cord-302082-aaokc182	90	11	usually	usually	RB
cord-302082-aaokc182	90	12	encoded	encode	VBN
cord-302082-aaokc182	90	13	in	in	IN
cord-302082-aaokc182	90	14	a	a	DT
cord-302082-aaokc182	90	15	circular	circular	JJ
cord-302082-aaokc182	90	16	plasmid	plasmid	NN
cord-302082-aaokc182	90	17	expression	expression	NN
cord-302082-aaokc182	90	18	vector	vector	NN
cord-302082-aaokc182	90	19	under	under	IN
cord-302082-aaokc182	90	20	the	the	DT
cord-302082-aaokc182	90	21	control	control	NN
cord-302082-aaokc182	90	22	of	of	IN
cord-302082-aaokc182	90	23	promoter	promoter	NN
cord-302082-aaokc182	90	24	sequences	sequence	NNS
cord-302082-aaokc182	90	25	that	that	WDT
cord-302082-aaokc182	90	26	direct	direct	JJ
cord-302082-aaokc182	90	27	gene	gene	NN
cord-302082-aaokc182	90	28	expression	expression	NN
cord-302082-aaokc182	90	29	in	in	IN
cord-302082-aaokc182	90	30	mammalian	mammalian	JJ
cord-302082-aaokc182	90	31	cells	cell	NNS
cord-302082-aaokc182	90	32	,	,	,
cord-302082-aaokc182	90	33	which	which	WDT
cord-302082-aaokc182	90	34	is	be	VBZ
cord-302082-aaokc182	90	35	achieved	achieve	VBN
cord-302082-aaokc182	90	36	after	after	IN
cord-302082-aaokc182	90	37	injection	injection	NN
cord-302082-aaokc182	90	38	into	into	IN
cord-302082-aaokc182	90	39	mammals	mammal	NNS
cord-302082-aaokc182	90	40	.	.	.
cord-302082-aaokc182	90	41	 	 	_SP
cord-302082-aaokc182	91	1	The	the	DT
cord-302082-aaokc182	91	2	DNA	dna	NN
cord-302082-aaokc182	91	3	vaccine	vaccine	NN
cord-302082-aaokc182	91	4	process	process	NN
cord-302082-aaokc182	91	5	can	can	MD
cord-302082-aaokc182	91	6	circumvent	circumvent	VB
cord-302082-aaokc182	91	7	some	some	DT
cord-302082-aaokc182	91	8	of	of	IN
cord-302082-aaokc182	91	9	the	the	DT
cord-302082-aaokc182	91	10	major	major	JJ
cord-302082-aaokc182	91	11	issues	issue	NNS
cord-302082-aaokc182	91	12	resulting	result	VBG
cord-302082-aaokc182	91	13	from	from	IN
cord-302082-aaokc182	91	14	recombinant	recombinant	JJ
cord-302082-aaokc182	91	15	protein	protein	NN
cord-302082-aaokc182	91	16	administration	administration	NN
cord-302082-aaokc182	91	17	.	.	.
cord-302082-aaokc182	92	1	The	the	DT
cord-302082-aaokc182	92	2	construction	construction	NN
cord-302082-aaokc182	92	3	and	and	CC
cord-302082-aaokc182	92	4	production	production	NN
cord-302082-aaokc182	92	5	of	of	IN
cord-302082-aaokc182	92	6	the	the	DT
cord-302082-aaokc182	92	7	plasmids	plasmid	NNS
cord-302082-aaokc182	92	8	carrying	carry	VBG
cord-302082-aaokc182	92	9	the	the	DT
cord-302082-aaokc182	92	10	gene	gene	NN
cord-302082-aaokc182	92	11	of	of	IN
cord-302082-aaokc182	92	12	interest	interest	NN
cord-302082-aaokc182	92	13	together	together	RB
cord-302082-aaokc182	92	14	with	with	IN
cord-302082-aaokc182	92	15	the	the	DT
cord-302082-aaokc182	92	16	promoter	promoter	NN
cord-302082-aaokc182	92	17	sequences	sequence	NNS
cord-302082-aaokc182	92	18	is	be	VBZ
cord-302082-aaokc182	92	19	relatively	relatively	RB
cord-302082-aaokc182	92	20	simple	simple	JJ
cord-302082-aaokc182	92	21	;	;	:
cord-302082-aaokc182	92	22	antigens	antigen	NNS
cord-302082-aaokc182	92	23	expressed	express	VBN
cord-302082-aaokc182	92	24	from	from	IN
cord-302082-aaokc182	92	25	plasmids	plasmid	NNS
cord-302082-aaokc182	92	26	retain	retain	VBP
cord-302082-aaokc182	92	27	their	-PRON-	PRP$
cord-302082-aaokc182	92	28	native	native	JJ
cord-302082-aaokc182	92	29	conformation	conformation	NN
cord-302082-aaokc182	92	30	,	,	,
cord-302082-aaokc182	92	31	the	the	DT
cord-302082-aaokc182	92	32	gene	gene	NN
cord-302082-aaokc182	92	33	can	can	MD
cord-302082-aaokc182	92	34	be	be	VB
cord-302082-aaokc182	92	35	readily	readily	RB
cord-302082-aaokc182	92	36	modified	modify	VBN
cord-302082-aaokc182	92	37	to	to	TO
cord-302082-aaokc182	92	38	produce	produce	VB
cord-302082-aaokc182	92	39	tailored	tailor	VBN
cord-302082-aaokc182	92	40	antigens	antigen	NNS
cord-302082-aaokc182	92	41	,	,	,
cord-302082-aaokc182	92	42	and	and	CC
cord-302082-aaokc182	92	43	bacterial	bacterial	JJ
cord-302082-aaokc182	92	44	plasmid	plasmid	NN
cord-302082-aaokc182	92	45	DNA	dna	NN
cord-302082-aaokc182	92	46	is	be	VBZ
cord-302082-aaokc182	92	47	intrinsically	intrinsically	RB
cord-302082-aaokc182	92	48	immunogenic	immunogenic	JJ
cord-302082-aaokc182	92	49	(	(	-LRB-
cord-302082-aaokc182	92	50	subsequently	subsequently	RB
cord-302082-aaokc182	92	51	shown	show	VBN
cord-302082-aaokc182	92	52	to	to	TO
cord-302082-aaokc182	92	53	result	result	VB
cord-302082-aaokc182	92	54	from	from	IN
cord-302082-aaokc182	92	55	the	the	DT
cord-302082-aaokc182	92	56	pathogen	pathogen	NN
cord-302082-aaokc182	92	57	-	-	HYPH
cord-302082-aaokc182	92	58	associated	associate	VBN
cord-302082-aaokc182	92	59	molecular	molecular	JJ
cord-302082-aaokc182	92	60	patterns	pattern	NNS
cord-302082-aaokc182	92	61	[	[	-LRB-
cord-302082-aaokc182	92	62	PAMPs	pamp	NNS
cord-302082-aaokc182	92	63	]	]	-RRB-
cord-302082-aaokc182	92	64	it	-PRON-	PRP
cord-302082-aaokc182	92	65	carries	carry	VBZ
cord-302082-aaokc182	92	66	)	)	-RRB-
cord-302082-aaokc182	92	67	.	.	.
cord-302082-aaokc182	93	1	Additional	additional	JJ
cord-302082-aaokc182	93	2	desirable	desirable	JJ
cord-302082-aaokc182	93	3	features	feature	NNS
cord-302082-aaokc182	93	4	include	include	VBP
cord-302082-aaokc182	93	5	the	the	DT
cord-302082-aaokc182	93	6	ability	ability	NN
cord-302082-aaokc182	93	7	to	to	TO
cord-302082-aaokc182	93	8	engineer	engineer	VB
cord-302082-aaokc182	93	9	and	and	CC
cord-302082-aaokc182	93	10	deliver	deliver	VB
cord-302082-aaokc182	93	11	genetic	genetic	JJ
cord-302082-aaokc182	93	12	adjuvants	adjuvant	NNS
cord-302082-aaokc182	93	13	in	in	IN
cord-302082-aaokc182	93	14	tandem	tandem	NN
cord-302082-aaokc182	93	15	or	or	CC
cord-302082-aaokc182	93	16	parallel	parallel	JJ
cord-302082-aaokc182	93	17	with	with	IN
cord-302082-aaokc182	93	18	the	the	DT
cord-302082-aaokc182	93	19	antigen	antigen	NN
cord-302082-aaokc182	93	20	,	,	,
cord-302082-aaokc182	93	21	the	the	DT
cord-302082-aaokc182	93	22	potential	potential	NN
cord-302082-aaokc182	93	23	to	to	TO
cord-302082-aaokc182	93	24	deliver	deliver	VB
cord-302082-aaokc182	93	25	multiple	multiple	JJ
cord-302082-aaokc182	93	26	antigen	antigen	NN
cord-302082-aaokc182	93	27	genes	gene	NNS
cord-302082-aaokc182	93	28	in	in	IN
cord-302082-aaokc182	93	29	one	one	CD
cord-302082-aaokc182	93	30	construct	construct	NN
cord-302082-aaokc182	93	31	or	or	CC
cord-302082-aaokc182	93	32	within	within	IN
cord-302082-aaokc182	93	33	other	other	JJ
cord-302082-aaokc182	93	34	constructs	construct	NNS
cord-302082-aaokc182	93	35	that	that	WDT
cord-302082-aaokc182	93	36	encode	encode	VBP
cord-302082-aaokc182	93	37	adjuvanting	adjuvante	VBG
cord-302082-aaokc182	93	38	protein(s	protein(s	NNP
cord-302082-aaokc182	93	39	)	)	-RRB-
cord-302082-aaokc182	93	40	,	,	,
cord-302082-aaokc182	93	41	and	and	CC
cord-302082-aaokc182	93	42	the	the	DT
cord-302082-aaokc182	93	43	ability	ability	NN
cord-302082-aaokc182	93	44	to	to	TO
cord-302082-aaokc182	93	45	induce	induce	VB
cord-302082-aaokc182	93	46	both	both	DT
cord-302082-aaokc182	93	47	cellular	cellular	JJ
cord-302082-aaokc182	93	48	and	and	CC
cord-302082-aaokc182	93	49	humoral	humoral	JJ
cord-302082-aaokc182	93	50	immune	immune	JJ
cord-302082-aaokc182	93	51	responses	response	NNS
cord-302082-aaokc182	93	52	.	.	.
cord-302082-aaokc182	94	1	Despite	despite	IN
cord-302082-aaokc182	94	2	promising	promising	JJ
cord-302082-aaokc182	94	3	data	datum	NNS
cord-302082-aaokc182	94	4	in	in	IN
cord-302082-aaokc182	94	5	pre	pre	JJ
cord-302082-aaokc182	94	6	-	-	JJ
cord-302082-aaokc182	94	7	clinical	clinical	JJ
cord-302082-aaokc182	94	8	testing	testing	NN
cord-302082-aaokc182	94	9	,	,	,
cord-302082-aaokc182	94	10	DNA	dna	NN
cord-302082-aaokc182	94	11	vaccine	vaccine	NN
cord-302082-aaokc182	94	12	candidates	candidate	NNS
cord-302082-aaokc182	94	13	have	have	VBP
cord-302082-aaokc182	94	14	shown	show	VBN
cord-302082-aaokc182	94	15	only	only	RB
cord-302082-aaokc182	94	16	limited	limited	JJ
cord-302082-aaokc182	94	17	success	success	NN
cord-302082-aaokc182	94	18	in	in	IN
cord-302082-aaokc182	94	19	clinical	clinical	JJ
cord-302082-aaokc182	94	20	settings	setting	NNS
cord-302082-aaokc182	94	21	so	so	RB
cord-302082-aaokc182	94	22	far	far	RB
cord-302082-aaokc182	94	23	.	.	.
cord-302082-aaokc182	95	1	One	one	CD
cord-302082-aaokc182	95	2	of	of	IN
cord-302082-aaokc182	95	3	the	the	DT
cord-302082-aaokc182	95	4	current	current	JJ
cord-302082-aaokc182	95	5	drawbacks	drawback	NNS
cord-302082-aaokc182	95	6	of	of	IN
cord-302082-aaokc182	95	7	DNA	dna	NN
cord-302082-aaokc182	95	8	vaccines	vaccine	NNS
cord-302082-aaokc182	95	9	is	be	VBZ
cord-302082-aaokc182	95	10	the	the	DT
cord-302082-aaokc182	95	11	inefficiency	inefficiency	NN
cord-302082-aaokc182	95	12	of	of	IN
cord-302082-aaokc182	95	13	conventional	conventional	JJ
cord-302082-aaokc182	95	14	delivery	delivery	NN
cord-302082-aaokc182	95	15	methods	method	NNS
cord-302082-aaokc182	95	16	for	for	IN
cord-302082-aaokc182	95	17	the	the	DT
cord-302082-aaokc182	95	18	plasmid	plasmid	NN
cord-302082-aaokc182	95	19	DNA	dna	NN
cord-302082-aaokc182	95	20	;	;	:
cord-302082-aaokc182	95	21	however	however	RB
cord-302082-aaokc182	95	22	,	,	,
cord-302082-aaokc182	95	23	 	 	_SP
cord-302082-aaokc182	95	24	UNDERSTANDING	understand	VBG
cord-302082-aaokc182	95	25	MODERN	modern	JJ
cord-302082-aaokc182	95	26	VACCINES	vaccine	NNS
cord-302082-aaokc182	95	27	emerging	emerge	VBG
cord-302082-aaokc182	95	28	proprietary	proprietary	JJ
cord-302082-aaokc182	95	29	particle	particle	NN
cord-302082-aaokc182	95	30	-	-	HYPH
cord-302082-aaokc182	95	31	mediated	mediate	VBN
cord-302082-aaokc182	95	32	delivery	delivery	NN
cord-302082-aaokc182	95	33	technology	technology	NN
cord-302082-aaokc182	95	34	or	or	CC
cord-302082-aaokc182	95	35	electroporation	electroporation	NN
cord-302082-aaokc182	95	36	technology	technology	NN
cord-302082-aaokc182	95	37	seeks	seek	VBZ
cord-302082-aaokc182	95	38	to	to	TO
cord-302082-aaokc182	95	39	improve	improve	VB
cord-302082-aaokc182	95	40	this	this	DT
cord-302082-aaokc182	95	41	situation	situation	NN
cord-302082-aaokc182	95	42	.	.	.
cord-302082-aaokc182	96	1	With	with	IN
cord-302082-aaokc182	96	2	the	the	DT
cord-302082-aaokc182	96	3	electroporation	electroporation	NN
cord-302082-aaokc182	96	4	method	method	NN
cord-302082-aaokc182	96	5	,	,	,
cord-302082-aaokc182	96	6	brief	brief	JJ
cord-302082-aaokc182	96	7	electrical	electrical	JJ
cord-302082-aaokc182	96	8	pulses	pulse	NNS
cord-302082-aaokc182	96	9	are	be	VBP
cord-302082-aaokc182	96	10	applied	apply	VBN
cord-302082-aaokc182	96	11	at	at	IN
cord-302082-aaokc182	96	12	the	the	DT
cord-302082-aaokc182	96	13	site	site	NN
cord-302082-aaokc182	96	14	of	of	IN
cord-302082-aaokc182	96	15	immunisation	immunisation	NN
cord-302082-aaokc182	96	16	which	which	WDT
cord-302082-aaokc182	96	17	causes	cause	VBZ
cord-302082-aaokc182	96	18	a	a	DT
cord-302082-aaokc182	96	19	transient	transient	JJ
cord-302082-aaokc182	96	20	disruption	disruption	NN
cord-302082-aaokc182	96	21	of	of	IN
cord-302082-aaokc182	96	22	cell	cell	NN
cord-302082-aaokc182	96	23	membranes	membrane	NNS
cord-302082-aaokc182	96	24	.	.	.
cord-302082-aaokc182	97	1	This	this	DT
cord-302082-aaokc182	97	2	results	result	VBZ
cord-302082-aaokc182	97	3	in	in	IN
cord-302082-aaokc182	97	4	an	an	DT
cord-302082-aaokc182	97	5	enhancement	enhancement	NN
cord-302082-aaokc182	97	6	in	in	IN
cord-302082-aaokc182	97	7	uptake	uptake	NN
cord-302082-aaokc182	97	8	of	of	IN
cord-302082-aaokc182	97	9	the	the	DT
cord-302082-aaokc182	97	10	DNA	dna	NN
cord-302082-aaokc182	97	11	vaccine	vaccine	NN
cord-302082-aaokc182	97	12	between	between	IN
cord-302082-aaokc182	97	13	10e100-fold	10e100-fold	CD
cord-302082-aaokc182	97	14	.	.	.
cord-302082-aaokc182	98	1	Examples	example	NNS
cord-302082-aaokc182	98	2	of	of	IN
cord-302082-aaokc182	98	3	DNA	dna	NN
cord-302082-aaokc182	98	4	candidate	candidate	NN
cord-302082-aaokc182	98	5	vaccines	vaccine	NNS
cord-302082-aaokc182	98	6	in	in	IN
cord-302082-aaokc182	98	7	clinical	clinical	JJ
cord-302082-aaokc182	98	8	development	development	NN
cord-302082-aaokc182	98	9	are	be	VBP
cord-302082-aaokc182	98	10	presented	present	VBN
cord-302082-aaokc182	98	11	in	in	IN
cord-302082-aaokc182	98	12	Table	Table	NNP
cord-302082-aaokc182	98	13	6	6	CD
cord-302082-aaokc182	98	14	.5	.5	CD
cord-302082-aaokc182	98	15	.	.	.
cord-302082-aaokc182	99	1	Dendritic	dendritic	JJ
cord-302082-aaokc182	99	2	cell	cell	NN
cord-302082-aaokc182	99	3	(	(	-LRB-
cord-302082-aaokc182	99	4	DC	DC	NNP
cord-302082-aaokc182	99	5	)	)	-RRB-
cord-302082-aaokc182	99	6	vaccines	vaccine	NNS
cord-302082-aaokc182	99	7	typically	typically	RB
cord-302082-aaokc182	99	8	use	use	VBP
cord-302082-aaokc182	99	9	monocytes	monocyte	NNS
cord-302082-aaokc182	99	10	harvested	harvest	VBN
cord-302082-aaokc182	99	11	from	from	IN
cord-302082-aaokc182	99	12	the	the	DT
cord-302082-aaokc182	99	13	blood	blood	NN
cord-302082-aaokc182	99	14	(	(	-LRB-
cord-302082-aaokc182	99	15	in	in	IN
cord-302082-aaokc182	99	16	most	most	JJS
cord-302082-aaokc182	99	17	cases	case	NNS
cord-302082-aaokc182	99	18	from	from	IN
cord-302082-aaokc182	99	19	the	the	DT
cord-302082-aaokc182	99	20	individual	individual	NN
cord-302082-aaokc182	99	21	who	who	WP
cord-302082-aaokc182	99	22	will	will	MD
cord-302082-aaokc182	99	23	receive	receive	VB
cord-302082-aaokc182	99	24	the	the	DT
cord-302082-aaokc182	99	25	vaccine	vaccine	NN
cord-302082-aaokc182	99	26	)	)	-RRB-
cord-302082-aaokc182	99	27	to	to	TO
cord-302082-aaokc182	99	28	produce	produce	VB
cord-302082-aaokc182	99	29	immature	immature	JJ
cord-302082-aaokc182	99	30	DCs	dc	NNS
cord-302082-aaokc182	99	31	in	in	IN
cord-302082-aaokc182	99	32	vitro	vitro	FW
cord-302082-aaokc182	99	33	.	.	.
cord-302082-aaokc182	100	1	The	the	DT
cord-302082-aaokc182	100	2	monocytes	monocyte	NNS
cord-302082-aaokc182	100	3	are	be	VBP
cord-302082-aaokc182	100	4	antigen	antigen	NN
cord-302082-aaokc182	100	5	-	-	HYPH
cord-302082-aaokc182	100	6	loaded	load	VBN
cord-302082-aaokc182	100	7	and	and	CC
cord-302082-aaokc182	100	8	treated	treat	VBN
cord-302082-aaokc182	100	9	to	to	TO
cord-302082-aaokc182	100	10	induce	induce	VB
cord-302082-aaokc182	100	11	their	-PRON-	PRP$
cord-302082-aaokc182	100	12	maturation	maturation	NN
cord-302082-aaokc182	100	13	into	into	IN
cord-302082-aaokc182	100	14	APCs	apc	NNS
cord-302082-aaokc182	100	15	and	and	CC
cord-302082-aaokc182	100	16	infused	infuse	VBD
cord-302082-aaokc182	100	17	back	back	RB
cord-302082-aaokc182	100	18	into	into	IN
cord-302082-aaokc182	100	19	the	the	DT
cord-302082-aaokc182	100	20	patient	patient	NN
cord-302082-aaokc182	100	21	.	.	.
cord-302082-aaokc182	101	1	The	the	DT
cord-302082-aaokc182	101	2	first	first	JJ
cord-302082-aaokc182	101	3	Food	Food	NNP
cord-302082-aaokc182	101	4	and	and	CC
cord-302082-aaokc182	101	5	Drug	Drug	NNP
cord-302082-aaokc182	101	6	Administration	Administration	NNP
cord-302082-aaokc182	101	7	(	(	-LRB-
cord-302082-aaokc182	101	8	FDA)-approved	FDA)-approved	NNP
cord-302082-aaokc182	101	9	DC	DC	NNP
cord-302082-aaokc182	101	10	vaccine	vaccine	NN
cord-302082-aaokc182	101	11	,	,	,
cord-302082-aaokc182	101	12	designed	design	VBN
cord-302082-aaokc182	101	13	for	for	IN
cord-302082-aaokc182	101	14	the	the	DT
cord-302082-aaokc182	101	15	treatment	treatment	NN
cord-302082-aaokc182	101	16	of	of	IN
cord-302082-aaokc182	101	17	prostate	prostate	NN
cord-302082-aaokc182	101	18	cancer	cancer	NN
cord-302082-aaokc182	101	19	,	,	,
cord-302082-aaokc182	101	20	was	be	VBD
cord-302082-aaokc182	101	21	licensed	license	VBN
cord-302082-aaokc182	101	22	in	in	IN
cord-302082-aaokc182	101	23	2010	2010	CD
cord-302082-aaokc182	101	24	(	(	-LRB-
cord-302082-aaokc182	101	25	Sipuleucel	Sipuleucel	NNP
cord-302082-aaokc182	101	26	-	-	HYPH
cord-302082-aaokc182	101	27	T	T	NNP
cord-302082-aaokc182	101	28	)	)	-RRB-
cord-302082-aaokc182	101	29	;	;	:
cord-302082-aaokc182	101	30	examples	example	NNS
cord-302082-aaokc182	101	31	of	of	IN
cord-302082-aaokc182	101	32	other	other	JJ
cord-302082-aaokc182	101	33	targets	target	NNS
cord-302082-aaokc182	101	34	for	for	IN
cord-302082-aaokc182	101	35	DC	DC	NNP
cord-302082-aaokc182	101	36	vaccine	vaccine	NN
cord-302082-aaokc182	101	37	therapy	therapy	NN
cord-302082-aaokc182	101	38	are	be	VBP
cord-302082-aaokc182	101	39	presented	present	VBN
cord-302082-aaokc182	101	40	in	in	IN
cord-302082-aaokc182	101	41	Table	Table	NNP
cord-302082-aaokc182	101	42	6	6	CD
cord-302082-aaokc182	101	43	.6	.6	CD
cord-302082-aaokc182	101	44	.	.	.
cord-302082-aaokc182	102	1	DC	DC	NNP
cord-302082-aaokc182	102	2	vaccines	vaccine	NNS
cord-302082-aaokc182	102	3	offer	offer	VBP
cord-302082-aaokc182	102	4	an	an	DT
cord-302082-aaokc182	102	5	individualised	individualised	JJ
cord-302082-aaokc182	102	6	approach	approach	NN
cord-302082-aaokc182	102	7	to	to	IN
cord-302082-aaokc182	102	8	therapeutic	therapeutic	JJ
cord-302082-aaokc182	102	9	vaccine	vaccine	NN
cord-302082-aaokc182	102	10	development	development	NN
cord-302082-aaokc182	102	11	,	,	,
cord-302082-aaokc182	102	12	but	but	CC
cord-302082-aaokc182	102	13	represent	represent	VB
cord-302082-aaokc182	102	14	a	a	DT
cord-302082-aaokc182	102	15	specialised	specialised	JJ
cord-302082-aaokc182	102	16	method	method	NN
cord-302082-aaokc182	102	17	of	of	IN
cord-302082-aaokc182	102	18	vaccination	vaccination	NN
cord-302082-aaokc182	102	19	that	that	WDT
cord-302082-aaokc182	102	20	is	be	VBZ
cord-302082-aaokc182	102	21	currently	currently	RB
cord-302082-aaokc182	102	22	limited	limit	VBN
cord-302082-aaokc182	102	23	to	to	IN
cord-302082-aaokc182	102	24	aggressive	aggressive	JJ
cord-302082-aaokc182	102	25	cancers	cancer	NNS
cord-302082-aaokc182	102	26	,	,	,
cord-302082-aaokc182	102	27	and	and	CC
cord-302082-aaokc182	102	28	the	the	DT
cord-302082-aaokc182	102	29	treatment	treatment	NN
cord-302082-aaokc182	102	30	of	of	IN
cord-302082-aaokc182	102	31	serious	serious	JJ
cord-302082-aaokc182	102	32	,	,	,
cord-302082-aaokc182	102	33	intractable	intractable	JJ
cord-302082-aaokc182	102	34	infections	infection	NNS
cord-302082-aaokc182	102	35	.	.	.
cord-302082-aaokc182	103	1	A	a	DT
cord-302082-aaokc182	103	2	comparison	comparison	NN
cord-302082-aaokc182	103	3	between	between	IN
cord-302082-aaokc182	103	4	the	the	DT
cord-302082-aaokc182	103	5	strengths	strength	NNS
cord-302082-aaokc182	103	6	and	and	CC
cord-302082-aaokc182	103	7	weaknesses	weakness	NNS
cord-302082-aaokc182	103	8	of	of	IN
cord-302082-aaokc182	103	9	selected	select	VBN
cord-302082-aaokc182	103	10	new	new	JJ
cord-302082-aaokc182	103	11	vaccine	vaccine	NN
cord-302082-aaokc182	103	12	platforms	platform	NNS
cord-302082-aaokc182	103	13	is	be	VBZ
cord-302082-aaokc182	103	14	presented	present	VBN
cord-302082-aaokc182	103	15	in	in	IN
cord-302082-aaokc182	103	16	Table	Table	NNP
cord-302082-aaokc182	103	17	6	6	CD
cord-302082-aaokc182	103	18	.7	.7	NFP
cord-302082-aaokc182	103	19	.	.	.
cord-302082-aaokc182	104	1	Developing	develop	VBG
cord-302082-aaokc182	104	2	administration	administration	NN
cord-302082-aaokc182	104	3	techniques	technique	NNS
cord-302082-aaokc182	104	4	that	that	WDT
cord-302082-aaokc182	104	5	place	place	VBP
cord-302082-aaokc182	104	6	the	the	DT
cord-302082-aaokc182	104	7	vaccine	vaccine	NN
cord-302082-aaokc182	104	8	directly	directly	RB
cord-302082-aaokc182	104	9	at	at	IN
cord-302082-aaokc182	104	10	the	the	DT
cord-302082-aaokc182	104	11	site(s	site(s	NNP
cord-302082-aaokc182	104	12	)	)	-RRB-
cord-302082-aaokc182	104	13	where	where	WRB
cord-302082-aaokc182	104	14	pathogens	pathogen	NNS
cord-302082-aaokc182	104	15	are	be	VBP
cord-302082-aaokc182	104	16	most	most	RBS
cord-302082-aaokc182	104	17	likely	likely	JJ
cord-302082-aaokc182	104	18	to	to	TO
cord-302082-aaokc182	104	19	initiate	initiate	VB
cord-302082-aaokc182	104	20	an	an	DT
cord-302082-aaokc182	104	21	infection	infection	NN
cord-302082-aaokc182	104	22	(	(	-LRB-
cord-302082-aaokc182	104	23	eg	eg	IN
cord-302082-aaokc182	104	24	mucosal	mucosal	JJ
cord-302082-aaokc182	104	25	or	or	CC
cord-302082-aaokc182	104	26	respiratory	respiratory	JJ
cord-302082-aaokc182	104	27	sites	site	NNS
cord-302082-aaokc182	104	28	)	)	-RRB-
cord-302082-aaokc182	104	29	is	be	VBZ
cord-302082-aaokc182	104	30	likely	likely	JJ
cord-302082-aaokc182	104	31	to	to	TO
cord-302082-aaokc182	104	32	improve	improve	VB
cord-302082-aaokc182	104	33	vaccine	vaccine	NN
cord-302082-aaokc182	104	34	efficacy	efficacy	NN
cord-302082-aaokc182	104	35	and	and	CC
cord-302082-aaokc182	104	36	safety	safety	NN
cord-302082-aaokc182	104	37	.	.	.
cord-302082-aaokc182	105	1	Traditional	traditional	JJ
cord-302082-aaokc182	105	2	methods	method	NNS
cord-302082-aaokc182	105	3	of	of	IN
cord-302082-aaokc182	105	4	vaccine	vaccine	NN
cord-302082-aaokc182	105	5	administration	administration	NN
cord-302082-aaokc182	105	6	can	can	MD
cord-302082-aaokc182	105	7	potentially	potentially	RB
cord-302082-aaokc182	105	8	pose	pose	VB
cord-302082-aaokc182	105	9	a	a	DT
cord-302082-aaokc182	105	10	number	number	NN
cord-302082-aaokc182	105	11	of	of	IN
cord-302082-aaokc182	105	12	limitations	limitation	NNS
cord-302082-aaokc182	105	13	with	with	IN
cord-302082-aaokc182	105	14	respect	respect	NN
cord-302082-aaokc182	105	15	to	to	IN
cord-302082-aaokc182	105	16	reactogenicity	reactogenicity	NN
cord-302082-aaokc182	105	17	,	,	,
cord-302082-aaokc182	105	18	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	105	19	,	,	,
cord-302082-aaokc182	105	20	convenience	convenience	NN
cord-302082-aaokc182	105	21	,	,	,
cord-302082-aaokc182	105	22	efficacy	efficacy	NN
cord-302082-aaokc182	105	23	,	,	,
cord-302082-aaokc182	105	24	safety	safety	NN
cord-302082-aaokc182	105	25	and	and	CC
cord-302082-aaokc182	105	26	cost	cost	NN
cord-302082-aaokc182	105	27	-	-	HYPH
cord-302082-aaokc182	105	28	effectiveness	effectiveness	NN
cord-302082-aaokc182	105	29	.	.	.
cord-302082-aaokc182	106	1	The	the	DT
cord-302082-aaokc182	106	2	information	information	NN
cord-302082-aaokc182	106	3	included	include	VBD
cord-302082-aaokc182	106	4	is	be	VBZ
cord-302082-aaokc182	106	5	not	not	RB
cord-302082-aaokc182	106	6	meant	mean	VBN
cord-302082-aaokc182	106	7	to	to	TO
cord-302082-aaokc182	106	8	be	be	VB
cord-302082-aaokc182	106	9	exhaustive	exhaustive	JJ
cord-302082-aaokc182	106	10	but	but	CC
cord-302082-aaokc182	106	11	is	be	VBZ
cord-302082-aaokc182	106	12	intended	intend	VBN
cord-302082-aaokc182	106	13	to	to	TO
cord-302082-aaokc182	106	14	provide	provide	VB
cord-302082-aaokc182	106	15	an	an	DT
cord-302082-aaokc182	106	16	overview	overview	NN
cord-302082-aaokc182	106	17	of	of	IN
cord-302082-aaokc182	106	18	the	the	DT
cord-302082-aaokc182	106	19	subject	subject	JJ
cord-302082-aaokc182	106	20	matter	matter	NN
cord-302082-aaokc182	106	21	.	.	.
cord-302082-aaokc182	107	1	Ongoing	ongoing	JJ
cord-302082-aaokc182	107	2	research	research	NN
cord-302082-aaokc182	107	3	on	on	IN
cord-302082-aaokc182	107	4	alternative	alternative	JJ
cord-302082-aaokc182	107	5	experimental	experimental	JJ
cord-302082-aaokc182	107	6	administration	administration	NN
cord-302082-aaokc182	107	7	strategies	strategy	NNS
cord-302082-aaokc182	107	8	includes	include	VBZ
cord-302082-aaokc182	107	9	ballistic	ballistic	JJ
cord-302082-aaokc182	107	10	delivery	delivery	NN
cord-302082-aaokc182	107	11	to	to	TO
cord-302082-aaokc182	107	12	skin	skin	VB
cord-302082-aaokc182	107	13	(	(	-LRB-
cord-302082-aaokc182	107	14	the	the	DT
cord-302082-aaokc182	107	15	gene	gene	NN
cord-302082-aaokc182	107	16	gun	gun	NN
cord-302082-aaokc182	107	17	)	)	-RRB-
cord-302082-aaokc182	107	18	,	,	,
cord-302082-aaokc182	107	19	the	the	DT
cord-302082-aaokc182	107	20	transdermal	transdermal	JJ
cord-302082-aaokc182	107	21	patch	patch	NN
cord-302082-aaokc182	107	22	and	and	CC
cord-302082-aaokc182	107	23	other	other	JJ
cord-302082-aaokc182	107	24	intradermal	intradermal	JJ
cord-302082-aaokc182	107	25	methods	method	NNS
cord-302082-aaokc182	107	26	,	,	,
cord-302082-aaokc182	107	27	plus	plus	CC
cord-302082-aaokc182	107	28	sublingual	sublingual	NN
cord-302082-aaokc182	107	29	,	,	,
cord-302082-aaokc182	107	30	aerosol	aerosol	NN
cord-302082-aaokc182	107	31	,	,	,
cord-302082-aaokc182	107	32	rectal	rectal	JJ
cord-302082-aaokc182	107	33	and	and	CC
cord-302082-aaokc182	107	34	vaginal	vaginal	JJ
cord-302082-aaokc182	107	35	mucosal	mucosal	JJ
cord-302082-aaokc182	107	36	vaccines	vaccine	NNS
cord-302082-aaokc182	107	37	.	.	.
cord-302082-aaokc182	108	1	The	the	DT
cord-302082-aaokc182	108	2	main	main	JJ
cord-302082-aaokc182	108	3	advantages	advantage	NNS
cord-302082-aaokc182	108	4	of	of	IN
cord-302082-aaokc182	108	5	alternative	alternative	JJ
cord-302082-aaokc182	108	6	delivery	delivery	NN
cord-302082-aaokc182	108	7	strategies	strategy	NNS
cord-302082-aaokc182	108	8	are	be	VBP
cord-302082-aaokc182	108	9	the	the	DT
cord-302082-aaokc182	108	10	potential	potential	NN
cord-302082-aaokc182	108	11	to	to	TO
cord-302082-aaokc182	108	12	induce	induce	VB
cord-302082-aaokc182	108	13	immune	immune	JJ
cord-302082-aaokc182	108	14	responses	response	NNS
cord-302082-aaokc182	108	15	at	at	IN
cord-302082-aaokc182	108	16	the	the	DT
cord-302082-aaokc182	108	17	common	common	JJ
cord-302082-aaokc182	108	18	portals	portal	NNS
cord-302082-aaokc182	108	19	of	of	IN
cord-302082-aaokc182	108	20	pathogen	pathogen	NN
cord-302082-aaokc182	108	21	entry	entry	NN
cord-302082-aaokc182	108	22	(	(	-LRB-
cord-302082-aaokc182	108	23	eg	eg	IN
cord-302082-aaokc182	108	24	oral	oral	JJ
cord-302082-aaokc182	108	25	polio	polio	NN
cord-302082-aaokc182	108	26	vaccine	vaccine	NN
cord-302082-aaokc182	108	27	replicating	replicate	VBG
cord-302082-aaokc182	108	28	in	in	IN
cord-302082-aaokc182	108	29	the	the	DT
cord-302082-aaokc182	108	30	gut	gut	NN
cord-302082-aaokc182	108	31	)	)	-RRB-
cord-302082-aaokc182	108	32	,	,	,
cord-302082-aaokc182	108	33	potential	potential	JJ
cord-302082-aaokc182	108	34	convenience	convenience	NN
cord-302082-aaokc182	108	35	(	(	-LRB-
cord-302082-aaokc182	108	36	eg	eg	IN
cord-302082-aaokc182	108	37	ease	ease	NN
cord-302082-aaokc182	108	38	of	of	IN
cord-302082-aaokc182	108	39	use	use	NN
cord-302082-aaokc182	108	40	of	of	IN
cord-302082-aaokc182	108	41	the	the	DT
cord-302082-aaokc182	108	42	transdermal	transdermal	JJ
cord-302082-aaokc182	108	43	patch	patch	NN
cord-302082-aaokc182	108	44	)	)	-RRB-
cord-302082-aaokc182	108	45	,	,	,
cord-302082-aaokc182	108	46	potential	potential	JJ
cord-302082-aaokc182	108	47	combination	combination	NN
cord-302082-aaokc182	108	48	of	of	IN
cord-302082-aaokc182	108	49	vaccines	vaccine	NNS
cord-302082-aaokc182	108	50	to	to	TO
cord-302082-aaokc182	108	51	reduce	reduce	VB
cord-302082-aaokc182	108	52	or	or	CC
cord-302082-aaokc182	108	53	simplify	simplify	VB
cord-302082-aaokc182	108	54	the	the	DT
cord-302082-aaokc182	108	55	vaccination	vaccination	NN
cord-302082-aaokc182	108	56	schedule	schedule	NN
cord-302082-aaokc182	108	57	,	,	,
cord-302082-aaokc182	108	58	and	and	CC
cord-302082-aaokc182	108	59	reduction	reduction	NN
cord-302082-aaokc182	108	60	or	or	CC
cord-302082-aaokc182	108	61	elimination	elimination	NN
cord-302082-aaokc182	108	62	of	of	IN
cord-302082-aaokc182	108	63	administration	administration	NN
cord-302082-aaokc182	108	64	via	via	IN
cord-302082-aaokc182	108	65	standard	standard	JJ
cord-302082-aaokc182	108	66	hypodermic	hypodermic	JJ
cord-302082-aaokc182	108	67	needle	needle	NN
cord-302082-aaokc182	108	68	injection	injection	NN
cord-302082-aaokc182	108	69	.	.	.
cord-302082-aaokc182	109	1	Despite	despite	IN
cord-302082-aaokc182	109	2	the	the	DT
cord-302082-aaokc182	109	3	intuitive	intuitive	JJ
cord-302082-aaokc182	109	4	value	value	NN
cord-302082-aaokc182	109	5	of	of	IN
cord-302082-aaokc182	109	6	these	these	DT
cord-302082-aaokc182	109	7	approaches	approach	NNS
cord-302082-aaokc182	109	8	,	,	,
cord-302082-aaokc182	109	9	few	few	JJ
cord-302082-aaokc182	109	10	vaccines	vaccine	NNS
cord-302082-aaokc182	109	11	today	today	NN
cord-302082-aaokc182	109	12	are	be	VBP
cord-302082-aaokc182	109	13	administered	administer	VBN
cord-302082-aaokc182	109	14	via	via	IN
cord-302082-aaokc182	109	15	non	non	JJ
cord-302082-aaokc182	109	16	-	-	JJ
cord-302082-aaokc182	109	17	IM	im	JJ
cord-302082-aaokc182	109	18	routes	route	NNS
cord-302082-aaokc182	109	19	.	.	.
cord-302082-aaokc182	110	1	This	this	DT
cord-302082-aaokc182	110	2	is	be	VBZ
cord-302082-aaokc182	110	3	for	for	IN
cord-302082-aaokc182	110	4	several	several	JJ
cord-302082-aaokc182	110	5	reasons	reason	NNS
cord-302082-aaokc182	110	6	including	include	VBG
cord-302082-aaokc182	110	7	feasibility	feasibility	NN
cord-302082-aaokc182	110	8	,	,	,
cord-302082-aaokc182	110	9	lack	lack	NN
cord-302082-aaokc182	110	10	of	of	IN
cord-302082-aaokc182	110	11	proven	prove	VBN
cord-302082-aaokc182	110	12	efficacy	efficacy	NN
cord-302082-aaokc182	110	13	and	and	CC
cord-302082-aaokc182	110	14	limited	limited	JJ
cord-302082-aaokc182	110	15	safety	safety	NN
cord-302082-aaokc182	110	16	data	datum	NNS
cord-302082-aaokc182	110	17	.	.	.
cord-302082-aaokc182	111	1	Some	some	DT
cord-302082-aaokc182	111	2	problems	problem	NNS
cord-302082-aaokc182	111	3	have	have	VBP
cord-302082-aaokc182	111	4	been	be	VBN
cord-302082-aaokc182	111	5	observed	observe	VBN
cord-302082-aaokc182	111	6	with	with	IN
cord-302082-aaokc182	111	7	new	new	JJ
cord-302082-aaokc182	111	8	routes	route	NNS
cord-302082-aaokc182	111	9	of	of	IN
cord-302082-aaokc182	111	10	delivery	delivery	NN
cord-302082-aaokc182	111	11	,	,	,
cord-302082-aaokc182	111	12	for	for	IN
cord-302082-aaokc182	111	13	example	example	NN
cord-302082-aaokc182	111	14	,	,	,
cord-302082-aaokc182	111	15	after	after	IN
cord-302082-aaokc182	111	16	the	the	DT
cord-302082-aaokc182	111	17	2000	2000	CD
cord-302082-aaokc182	111	18	launch	launch	NN
cord-302082-aaokc182	111	19	of	of	IN
cord-302082-aaokc182	111	20	an	an	DT
cord-302082-aaokc182	111	21	inactivated	inactivate	VBN
cord-302082-aaokc182	111	22	intranasal	intranasal	NN
cord-302082-aaokc182	111	23	influenza	influenza	NN
cord-302082-aaokc182	111	24	vaccine	vaccine	NN
cord-302082-aaokc182	111	25	(	(	-LRB-
cord-302082-aaokc182	111	26	a	a	DT
cord-302082-aaokc182	111	27	virosome	virosome	NNP
cord-302082-aaokc182	111	28	formulation	formulation	NN
cord-302082-aaokc182	111	29	adjuvanted	adjuvante	VBN
cord-302082-aaokc182	111	30	by	by	IN
cord-302082-aaokc182	111	31	heat	heat	NN
cord-302082-aaokc182	111	32	labile	labile	JJ
cord-302082-aaokc182	111	33	enterotoxoid	enterotoxoid	NN
cord-302082-aaokc182	111	34	of	of	IN
cord-302082-aaokc182	111	35	Escherichia	Escherichia	NNP
cord-302082-aaokc182	111	36	coli	coli	NNS
cord-302082-aaokc182	111	37	)	)	-RRB-
cord-302082-aaokc182	111	38	,	,	,
cord-302082-aaokc182	111	39	post	post	JJ
cord-302082-aaokc182	111	40	-	-	JJ
cord-302082-aaokc182	111	41	licensure	licensure	JJ
cord-302082-aaokc182	111	42	data	datum	NNS
cord-302082-aaokc182	111	43	indicated	indicate	VBD
cord-302082-aaokc182	111	44	a	a	DT
cord-302082-aaokc182	111	45	significantly	significantly	RB
cord-302082-aaokc182	111	46	increased	increase	VBN
cord-302082-aaokc182	111	47	risk	risk	NN
cord-302082-aaokc182	111	48	of	of	IN
cord-302082-aaokc182	111	49	Bell	Bell	NNP
cord-302082-aaokc182	111	50	's	's	POS
cord-302082-aaokc182	111	51	palsy	palsy	NN
cord-302082-aaokc182	111	52	in	in	IN
cord-302082-aaokc182	111	53	vaccinees	vaccinees	NNP
cord-302082-aaokc182	111	54	and	and	CC
cord-302082-aaokc182	111	55	forced	force	VBD
cord-302082-aaokc182	111	56	its	-PRON-	PRP$
cord-302082-aaokc182	111	57	withdrawal	withdrawal	NN
cord-302082-aaokc182	111	58	from	from	IN
cord-302082-aaokc182	111	59	the	the	DT
cord-302082-aaokc182	111	60	market	market	NN
cord-302082-aaokc182	111	61	.	.	.
cord-302082-aaokc182	112	1	This	this	DT
cord-302082-aaokc182	112	2	experience	experience	NN
cord-302082-aaokc182	112	3	led	lead	VBD
cord-302082-aaokc182	112	4	to	to	IN
cord-302082-aaokc182	112	5	a	a	DT
cord-302082-aaokc182	112	6	higher	high	JJR
cord-302082-aaokc182	112	7	level	level	NN
cord-302082-aaokc182	112	8	of	of	IN
cord-302082-aaokc182	112	9	caution	caution	NN
cord-302082-aaokc182	112	10	in	in	IN
cord-302082-aaokc182	112	11	the	the	DT
cord-302082-aaokc182	112	12	development	development	NN
cord-302082-aaokc182	112	13	of	of	IN
cord-302082-aaokc182	112	14	intranasal	intranasal	NN
cord-302082-aaokc182	112	15	vaccines	vaccine	NNS
cord-302082-aaokc182	112	16	.	.	.
cord-302082-aaokc182	113	1	Today	today	NN
cord-302082-aaokc182	113	2	,	,	,
cord-302082-aaokc182	113	3	the	the	DT
cord-302082-aaokc182	113	4	only	only	JJ
cord-302082-aaokc182	113	5	example	example	NN
cord-302082-aaokc182	113	6	of	of	IN
cord-302082-aaokc182	113	7	a	a	DT
cord-302082-aaokc182	113	8	licensed	licensed	JJ
cord-302082-aaokc182	113	9	vaccine	vaccine	NN
cord-302082-aaokc182	113	10	against	against	IN
cord-302082-aaokc182	113	11	a	a	DT
cord-302082-aaokc182	113	12	latent	latent	JJ
cord-302082-aaokc182	113	13	infection	infection	NN
cord-302082-aaokc182	113	14	is	be	VBZ
cord-302082-aaokc182	113	15	the	the	DT
cord-302082-aaokc182	113	16	zoster	zoster	NNP
cord-302082-aaokc182	113	17	vaccine	vaccine	NN
cord-302082-aaokc182	113	18	;	;	:
cord-302082-aaokc182	113	19	the	the	DT
cord-302082-aaokc182	113	20	vaccine	vaccine	NN
cord-302082-aaokc182	113	21	formulation	formulation	NN
cord-302082-aaokc182	113	22	is	be	VBZ
cord-302082-aaokc182	113	23	the	the	DT
cord-302082-aaokc182	113	24	high	high	JJ
cord-302082-aaokc182	113	25	potency	potency	NN
cord-302082-aaokc182	113	26	(	(	-LRB-
cord-302082-aaokc182	113	27	about	about	RB
cord-302082-aaokc182	113	28	15-fold	15-fold	CD
cord-302082-aaokc182	113	29	)	)	-RRB-
cord-302082-aaokc182	113	30	version	version	NN
cord-302082-aaokc182	113	31	of	of	IN
cord-302082-aaokc182	113	32	the	the	DT
cord-302082-aaokc182	113	33	live	live	JJ
cord-302082-aaokc182	113	34	,	,	,
cord-302082-aaokc182	113	35	attenuated	attenuated	JJ
cord-302082-aaokc182	113	36	varicella	varicella	NN
cord-302082-aaokc182	113	37	zoster	zoster	NN
cord-302082-aaokc182	113	38	virus	virus	NN
cord-302082-aaokc182	113	39	(	(	-LRB-
cord-302082-aaokc182	113	40	VZV	VZV	NNP
cord-302082-aaokc182	113	41	)	)	-RRB-
cord-302082-aaokc182	113	42	vaccine	vaccine	NN
cord-302082-aaokc182	113	43	.	.	.
cord-302082-aaokc182	114	1	This	this	DT
cord-302082-aaokc182	114	2	vaccine	vaccine	NN
cord-302082-aaokc182	114	3	has	have	VBZ
cord-302082-aaokc182	114	4	been	be	VBN
cord-302082-aaokc182	114	5	used	use	VBN
cord-302082-aaokc182	114	6	to	to	TO
cord-302082-aaokc182	114	7	boost	boost	VB
cord-302082-aaokc182	114	8	the	the	DT
cord-302082-aaokc182	114	9	anti	anti	JJ
cord-302082-aaokc182	114	10	-	-	JJ
cord-302082-aaokc182	114	11	VZV	vzv	JJ
cord-302082-aaokc182	114	12	cell	cell	NN
cord-302082-aaokc182	114	13	-	-	HYPH
cord-302082-aaokc182	114	14	mediated	mediate	VBN
cord-302082-aaokc182	114	15	immune	immune	JJ
cord-302082-aaokc182	114	16	response	response	NN
cord-302082-aaokc182	114	17	in	in	IN
cord-302082-aaokc182	114	18	older	old	JJR
cord-302082-aaokc182	114	19	subjects	subject	NNS
cord-302082-aaokc182	114	20	and	and	CC
cord-302082-aaokc182	114	21	has	have	VBZ
cord-302082-aaokc182	114	22	been	be	VBN
cord-302082-aaokc182	114	23	shown	show	VBN
cord-302082-aaokc182	114	24	to	to	TO
cord-302082-aaokc182	114	25	reduce	reduce	VB
cord-302082-aaokc182	114	26	the	the	DT
cord-302082-aaokc182	114	27	overall	overall	JJ
cord-302082-aaokc182	114	28	incidence	incidence	NN
cord-302082-aaokc182	114	29	of	of	IN
cord-302082-aaokc182	114	30	zoster	zoster	NN
cord-302082-aaokc182	114	31	by	by	IN
cord-302082-aaokc182	114	32	50	50	CD
cord-302082-aaokc182	114	33	%	%	NN
cord-302082-aaokc182	114	34	in	in	IN
cord-302082-aaokc182	114	35	subjects	subject	NNS
cord-302082-aaokc182	114	36	aged	age	VBN
cord-302082-aaokc182	114	37	60	60	CD
cord-302082-aaokc182	114	38	years	year	NNS
cord-302082-aaokc182	114	39	or	or	CC
cord-302082-aaokc182	114	40	older	old	JJR
cord-302082-aaokc182	115	1	(	(	-LRB-
cord-302082-aaokc182	115	2	Oxman	Oxman	NNP
cord-302082-aaokc182	115	3	et	et	FW
cord-302082-aaokc182	115	4	al	al	NNP
cord-302082-aaokc182	115	5	.	.	NNP
cord-302082-aaokc182	115	6	,	,	,
cord-302082-aaokc182	115	7	2005	2005	CD
cord-302082-aaokc182	115	8	)	)	-RRB-
cord-302082-aaokc182	115	9	.	.	.
cord-302082-aaokc182	116	1	Future	future	JJ
cord-302082-aaokc182	116	2	vaccines	vaccine	NNS
cord-302082-aaokc182	116	3	may	may	MD
cord-302082-aaokc182	116	4	control	control	VB
cord-302082-aaokc182	116	5	persistent	persistent	JJ
cord-302082-aaokc182	116	6	infections	infection	NNS
cord-302082-aaokc182	116	7	either	either	CC
cord-302082-aaokc182	116	8	by	by	IN
cord-302082-aaokc182	116	9	preventing	prevent	VBG
cord-302082-aaokc182	116	10	the	the	DT
cord-302082-aaokc182	116	11	initial	initial	JJ
cord-302082-aaokc182	116	12	infection	infection	NN
cord-302082-aaokc182	116	13	or	or	CC
cord-302082-aaokc182	116	14	disease	disease	NN
cord-302082-aaokc182	116	15	(	(	-LRB-
cord-302082-aaokc182	116	16	ie	ie	FW
cord-302082-aaokc182	116	17	prophylactic	prophylactic	JJ
cord-302082-aaokc182	116	18	vaccines	vaccine	NNS
cord-302082-aaokc182	116	19	)	)	-RRB-
cord-302082-aaokc182	117	1	Aerosol	aerosol	NN
cord-302082-aaokc182	117	2	delivery	delivery	NN
cord-302082-aaokc182	117	3	:	:	:
cord-302082-aaokc182	117	4	'	'	''
cord-302082-aaokc182	118	1	Mass	mass	JJ
cord-302082-aaokc182	118	2	immunization	immunization	NN
cord-302082-aaokc182	118	3	of	of	IN
cord-302082-aaokc182	118	4	almost	almost	RB
cord-302082-aaokc182	118	5	all	all	DT
cord-302082-aaokc182	118	6	susceptible	susceptible	JJ
cord-302082-aaokc182	118	7	children	child	NNS
cord-302082-aaokc182	118	8	in	in	IN
cord-302082-aaokc182	118	9	a	a	DT
cord-302082-aaokc182	118	10	short	short	JJ
cord-302082-aaokc182	118	11	period	period	NN
cord-302082-aaokc182	118	12	of	of	IN
cord-302082-aaokc182	118	13	time	time	NN
cord-302082-aaokc182	118	14	,	,	,
cord-302082-aaokc182	118	15	has	have	VBZ
cord-302082-aaokc182	118	16	the	the	DT
cord-302082-aaokc182	118	17	potential	potential	NN
cord-302082-aaokc182	118	18	of	of	IN
cord-302082-aaokc182	118	19	rapidly	rapidly	RB
cord-302082-aaokc182	118	20	eliminating	eliminate	VBG
cord-302082-aaokc182	118	21	measles	measle	NNS
cord-302082-aaokc182	118	22	as	as	IN
cord-302082-aaokc182	118	23	a	a	DT
cord-302082-aaokc182	118	24	public	public	JJ
cord-302082-aaokc182	118	25	health	health	NN
cord-302082-aaokc182	118	26	problem	problem	NN
cord-302082-aaokc182	118	27	.	.	.
cord-302082-aaokc182	119	1	Immunization	immunization	NN
cord-302082-aaokc182	119	2	by	by	IN
cord-302082-aaokc182	119	3	inhalation	inhalation	NN
cord-302082-aaokc182	119	4	of	of	IN
cord-302082-aaokc182	119	5	aerosolised	aerosolised	JJ
cord-302082-aaokc182	119	6	measles	measles	NNP
cord-302082-aaokc182	119	7	vaccine	vaccine	NN
cord-302082-aaokc182	119	8	provides	provide	VBZ
cord-302082-aaokc182	119	9	a	a	DT
cord-302082-aaokc182	119	10	procedure	procedure	NN
cord-302082-aaokc182	119	11	that	that	WDT
cord-302082-aaokc182	119	12	could	could	MD
cord-302082-aaokc182	119	13	make	make	VB
cord-302082-aaokc182	119	14	such	such	PDT
cord-302082-aaokc182	119	15	a	a	DT
cord-302082-aaokc182	119	16	mass	mass	NN
cord-302082-aaokc182	119	17	programme	programme	NN
cord-302082-aaokc182	119	18	possible	possible	JJ
cord-302082-aaokc182	119	19	,	,	,
cord-302082-aaokc182	119	20	especially	especially	RB
cord-302082-aaokc182	119	21	in	in	IN
cord-302082-aaokc182	119	22	parts	part	NNS
cord-302082-aaokc182	119	23	of	of	IN
cord-302082-aaokc182	119	24	the	the	DT
cord-302082-aaokc182	119	25	world	world	NN
cord-302082-aaokc182	119	26	where	where	WRB
cord-302082-aaokc182	119	27	measles	measles	NN
cord-302082-aaokc182	119	28	continues	continue	VBZ
cord-302082-aaokc182	119	29	to	to	TO
cord-302082-aaokc182	119	30	be	be	VB
cord-302082-aaokc182	119	31	a	a	DT
cord-302082-aaokc182	119	32	serious	serious	JJ
cord-302082-aaokc182	119	33	problem	problem	NN
cord-302082-aaokc182	119	34	.	.	.
cord-302082-aaokc182	119	35	'	'	''
cord-302082-aaokc182	120	1	(	(	-LRB-
cord-302082-aaokc182	120	2	Sabin	Sabin	NNP
cord-302082-aaokc182	120	3	et	et	NNP
cord-302082-aaokc182	120	4	al	al	NNP
cord-302082-aaokc182	120	5	.	.	NNP
cord-302082-aaokc182	120	6	,	,	,
cord-302082-aaokc182	120	7	1983	1983	CD
cord-302082-aaokc182	120	8	)	)	-RRB-
cord-302082-aaokc182	120	9	.	.	.
cord-302082-aaokc182	121	1	Administering	administer	VBG
cord-302082-aaokc182	121	2	the	the	DT
cord-302082-aaokc182	121	3	measles	measle	NNS
cord-302082-aaokc182	121	4	vaccine	vaccine	NN
cord-302082-aaokc182	121	5	as	as	IN
cord-302082-aaokc182	121	6	an	an	DT
cord-302082-aaokc182	121	7	aerosol	aerosol	NN
cord-302082-aaokc182	121	8	,	,	,
cord-302082-aaokc182	121	9	either	either	CC
cord-302082-aaokc182	121	10	as	as	IN
cord-302082-aaokc182	121	11	nebulised	nebulised	JJ
cord-302082-aaokc182	121	12	vaccine	vaccine	NN
cord-302082-aaokc182	121	13	or	or	CC
cord-302082-aaokc182	121	14	as	as	IN
cord-302082-aaokc182	121	15	An	an	DT
cord-302082-aaokc182	121	16	increased	increase	VBN
cord-302082-aaokc182	121	17	understanding	understanding	NN
cord-302082-aaokc182	121	18	of	of	IN
cord-302082-aaokc182	121	19	human	human	JJ
cord-302082-aaokc182	121	20	immunology	immunology	NN
cord-302082-aaokc182	121	21	and	and	CC
cord-302082-aaokc182	121	22	of	of	IN
cord-302082-aaokc182	121	23	hostepathogen	hostepathogen	NNP
cord-302082-aaokc182	121	24	interactions	interaction	NNS
cord-302082-aaokc182	121	25	should	should	MD
cord-302082-aaokc182	121	26	enable	enable	VB
cord-302082-aaokc182	121	27	the	the	DT
cord-302082-aaokc182	121	28	identification	identification	NN
cord-302082-aaokc182	121	29	of	of	IN
cord-302082-aaokc182	121	30	the	the	DT
cord-302082-aaokc182	121	31	type(s	type(s	NNP
cord-302082-aaokc182	121	32	)	)	-RRB-
cord-302082-aaokc182	121	33	of	of	IN
cord-302082-aaokc182	121	34	immunity	immunity	NN
cord-302082-aaokc182	121	35	required	require	VBN
cord-302082-aaokc182	121	36	to	to	TO
cord-302082-aaokc182	121	37	effectively	effectively	RB
cord-302082-aaokc182	121	38	prevent	prevent	VB
cord-302082-aaokc182	121	39	or	or	CC
cord-302082-aaokc182	121	40	control	control	VB
cord-302082-aaokc182	121	41	persistent	persistent	JJ
cord-302082-aaokc182	121	42	infections	infection	NNS
cord-302082-aaokc182	121	43	(	(	-LRB-
cord-302082-aaokc182	121	44	see	see	VB
cord-302082-aaokc182	121	45	Chapter	chapter	NN
cord-302082-aaokc182	121	46	2	2	CD
cord-302082-aaokc182	121	47	e	e	NN
cord-302082-aaokc182	121	48	Vaccine	vaccine	NN
cord-302082-aaokc182	121	49	immunology	immunology	NN
cord-302082-aaokc182	121	50	)	)	-RRB-
cord-302082-aaokc182	121	51	.	.	.
cord-302082-aaokc182	122	1	Some	some	DT
cord-302082-aaokc182	122	2	examples	example	NNS
cord-302082-aaokc182	122	3	of	of	IN
cord-302082-aaokc182	122	4	persistent	persistent	JJ
cord-302082-aaokc182	122	5	infections	infection	NNS
cord-302082-aaokc182	122	6	are	be	VBP
cord-302082-aaokc182	122	7	shown	show	VBN
cord-302082-aaokc182	122	8	in	in	IN
cord-302082-aaokc182	122	9	Table	Table	NNP
cord-302082-aaokc182	122	10	6	6	CD
cord-302082-aaokc182	122	11	.8	.8	CD
cord-302082-aaokc182	122	12	.	.	.
cord-302082-aaokc182	123	1	Mycobacterium	mycobacterium	NN
cord-302082-aaokc182	123	2	tuberculosis	tuberculosis	NN
cord-302082-aaokc182	123	3	can	can	MD
cord-302082-aaokc182	123	4	persist	persist	VB
cord-302082-aaokc182	123	5	in	in	IN
cord-302082-aaokc182	123	6	a	a	DT
cord-302082-aaokc182	123	7	latent	latent	JJ
cord-302082-aaokc182	123	8	state	state	NN
cord-302082-aaokc182	123	9	within	within	IN
cord-302082-aaokc182	123	10	the	the	DT
cord-302082-aaokc182	123	11	human	human	JJ
cord-302082-aaokc182	123	12	host	host	NN
cord-302082-aaokc182	123	13	for	for	IN
cord-302082-aaokc182	123	14	years	year	NNS
cord-302082-aaokc182	123	15	without	without	IN
cord-302082-aaokc182	123	16	causing	cause	VBG
cord-302082-aaokc182	123	17	disease	disease	NN
cord-302082-aaokc182	123	18	(	(	-LRB-
cord-302082-aaokc182	123	19	latent	latent	JJ
cord-302082-aaokc182	123	20	TB	TB	NNP
cord-302082-aaokc182	123	21	)	)	-RRB-
cord-302082-aaokc182	123	22	.	.	.
cord-302082-aaokc182	124	1	Protection	protection	NN
cord-302082-aaokc182	124	2	against	against	IN
cord-302082-aaokc182	124	3	miliary	miliary	JJ
cord-302082-aaokc182	124	4	(	(	-LRB-
cord-302082-aaokc182	124	5	disseminated	disseminate	VBN
cord-302082-aaokc182	124	6	)	)	-RRB-
cord-302082-aaokc182	124	7	TB	TB	NNP
cord-302082-aaokc182	124	8	in	in	IN
cord-302082-aaokc182	124	9	children	child	NNS
cord-302082-aaokc182	124	10	is	be	VBZ
cord-302082-aaokc182	124	11	provided	provide	VBN
cord-302082-aaokc182	124	12	by	by	IN
cord-302082-aaokc182	124	13	the	the	DT
cord-302082-aaokc182	124	14	bacille	bacille	NNP
cord-302082-aaokc182	124	15	CalmetteeGuérin	CalmetteeGuérin	NNP
cord-302082-aaokc182	124	16	(	(	-LRB-
cord-302082-aaokc182	124	17	BCG	BCG	NNP
cord-302082-aaokc182	124	18	)	)	-RRB-
cord-302082-aaokc182	124	19	vaccine	vaccine	NN
cord-302082-aaokc182	124	20	,	,	,
cord-302082-aaokc182	124	21	developed	develop	VBN
cord-302082-aaokc182	124	22	through	through	IN
cord-302082-aaokc182	124	23	culture	culture	NN
cord-302082-aaokc182	124	24	attenuation	attenuation	NN
cord-302082-aaokc182	124	25	of	of	IN
cord-302082-aaokc182	124	26	Mycobacterium	Mycobacterium	NNP
cord-302082-aaokc182	124	27	bovis	bovis	NN
cord-302082-aaokc182	124	28	early	early	RB
cord-302082-aaokc182	124	29	in	in	IN
cord-302082-aaokc182	124	30	the	the	DT
cord-302082-aaokc182	124	31	20th	20th	JJ
cord-302082-aaokc182	124	32	century	century	NN
cord-302082-aaokc182	124	33	,	,	,
cord-302082-aaokc182	124	34	which	which	WDT
cord-302082-aaokc182	124	35	is	be	VBZ
cord-302082-aaokc182	124	36	routinely	routinely	RB
cord-302082-aaokc182	124	37	given	give	VBN
cord-302082-aaokc182	124	38	in	in	IN
cord-302082-aaokc182	124	39	many	many	JJ
cord-302082-aaokc182	124	40	countries	country	NNS
cord-302082-aaokc182	124	41	.	.	.
cord-302082-aaokc182	125	1	The	the	DT
cord-302082-aaokc182	125	2	vaccine	vaccine	NN
cord-302082-aaokc182	125	3	,	,	,
cord-302082-aaokc182	125	4	however	however	RB
cord-302082-aaokc182	125	5	,	,	,
cord-302082-aaokc182	125	6	provides	provide	VBZ
cord-302082-aaokc182	125	7	only	only	RB
cord-302082-aaokc182	125	8	modest	modest	JJ
cord-302082-aaokc182	125	9	and	and	CC
cord-302082-aaokc182	125	10	often	often	RB
cord-302082-aaokc182	125	11	temporary	temporary	JJ
cord-302082-aaokc182	125	12	protection	protection	NN
cord-302082-aaokc182	125	13	against	against	IN
cord-302082-aaokc182	125	14	pulmonary	pulmonary	JJ
cord-302082-aaokc182	125	15	TB	TB	NNP
cord-302082-aaokc182	125	16	,	,	,
cord-302082-aaokc182	125	17	and	and	CC
cord-302082-aaokc182	125	18	provides	provide	VBZ
cord-302082-aaokc182	125	19	lower	low	JJR
cord-302082-aaokc182	125	20	efficacy	efficacy	NN
cord-302082-aaokc182	125	21	in	in	IN
cord-302082-aaokc182	125	22	resource	resource	NN
cord-302082-aaokc182	125	23	-	-	HYPH
cord-302082-aaokc182	125	24	limited	limit	VBN
cord-302082-aaokc182	125	25	regions	region	NNS
cord-302082-aaokc182	125	26	closer	close	RBR
cord-302082-aaokc182	125	27	to	to	IN
cord-302082-aaokc182	125	28	the	the	DT
cord-302082-aaokc182	125	29	equator	equator	NN
cord-302082-aaokc182	125	30	.	.	.
cord-302082-aaokc182	126	1	In	in	IN
cord-302082-aaokc182	126	2	addition	addition	NN
cord-302082-aaokc182	126	3	,	,	,
cord-302082-aaokc182	126	4	vaccination	vaccination	NN
cord-302082-aaokc182	126	5	with	with	IN
cord-302082-aaokc182	126	6	live	live	JJ
cord-302082-aaokc182	126	7	,	,	,
cord-302082-aaokc182	126	8	attenuated	attenuated	JJ
cord-302082-aaokc182	126	9	Mycobacterium	Mycobacterium	NNP
cord-302082-aaokc182	126	10	bovis	bovis	NN
cord-302082-aaokc182	126	11	is	be	VBZ
cord-302082-aaokc182	126	12	a	a	DT
cord-302082-aaokc182	126	13	particular	particular	JJ
cord-302082-aaokc182	126	14	concern	concern	NN
cord-302082-aaokc182	126	15	in	in	IN
cord-302082-aaokc182	126	16	HIV	HIV	NNP
cord-302082-aaokc182	126	17	-	-	HYPH
cord-302082-aaokc182	126	18	positive	positive	JJ
cord-302082-aaokc182	126	19	individuals	individual	NNS
cord-302082-aaokc182	126	20	,	,	,
cord-302082-aaokc182	126	21	especially	especially	RB
cord-302082-aaokc182	126	22	those	those	DT
cord-302082-aaokc182	126	23	with	with	IN
cord-302082-aaokc182	126	24	advanced	advanced	JJ
cord-302082-aaokc182	126	25	immune	immune	JJ
cord-302082-aaokc182	126	26	suppression	suppression	NN
cord-302082-aaokc182	126	27	;	;	:
cord-302082-aaokc182	126	28	this	this	DT
cord-302082-aaokc182	126	29	population	population	NN
cord-302082-aaokc182	126	30	would	would	MD
cord-302082-aaokc182	126	31	particularly	particularly	RB
cord-302082-aaokc182	126	32	benefit	benefit	VB
cord-302082-aaokc182	126	33	from	from	IN
cord-302082-aaokc182	126	34	TB	TB	NNP
cord-302082-aaokc182	126	35	vaccination	vaccination	NN
cord-302082-aaokc182	126	36	as	as	IN
cord-302082-aaokc182	126	37	TB	TB	NNP
cord-302082-aaokc182	126	38	is	be	VBZ
cord-302082-aaokc182	126	39	a	a	DT
cord-302082-aaokc182	126	40	leading	leading	JJ
cord-302082-aaokc182	126	41	cause	cause	NN
cord-302082-aaokc182	126	42	of	of	IN
cord-302082-aaokc182	126	43	death	death	NN
cord-302082-aaokc182	126	44	worldwide	worldwide	RB
cord-302082-aaokc182	126	45	for	for	IN
cord-302082-aaokc182	126	46	people	people	NNS
cord-302082-aaokc182	126	47	with	with	IN
cord-302082-aaokc182	126	48	HIV	HIV	NNP
cord-302082-aaokc182	126	49	/	/	SYM
cord-302082-aaokc182	126	50	acquired	acquire	VBN
cord-302082-aaokc182	126	51	immunodeficiency	immunodeficiency	NN
cord-302082-aaokc182	126	52	syndrome	syndrome	NN
cord-302082-aaokc182	126	53	(	(	-LRB-
cord-302082-aaokc182	126	54	AIDS	AIDS	NNP
cord-302082-aaokc182	126	55	)	)	-RRB-
cord-302082-aaokc182	126	56	.	.	.
cord-302082-aaokc182	127	1	However	however	RB
cord-302082-aaokc182	127	2	,	,	,
cord-302082-aaokc182	127	3	a	a	DT
cord-302082-aaokc182	127	4	recent	recent	JJ
cord-302082-aaokc182	127	5	Phase	Phase	NNP
cord-302082-aaokc182	127	6	III	iii	CD
cord-302082-aaokc182	127	7	trial	trial	NN
cord-302082-aaokc182	127	8	demonstrated	demonstrate	VBD
cord-302082-aaokc182	127	9	that	that	IN
cord-302082-aaokc182	127	10	protection	protection	NN
cord-302082-aaokc182	127	11	against	against	IN
cord-302082-aaokc182	127	12	TB	TB	NNP
cord-302082-aaokc182	127	13	can	can	MD
cord-302082-aaokc182	127	14	be	be	VB
cord-302082-aaokc182	127	15	provided	provide	VBN
cord-302082-aaokc182	127	16	to	to	IN
cord-302082-aaokc182	127	17	individuals	individual	NNS
cord-302082-aaokc182	127	18	with	with	IN
cord-302082-aaokc182	127	19	HIV	HIV	NNP
cord-302082-aaokc182	127	20	by	by	IN
cord-302082-aaokc182	127	21	using	use	VBG
cord-302082-aaokc182	127	22	an	an	DT
cord-302082-aaokc182	127	23	inactivated	inactivate	VBN
cord-302082-aaokc182	127	24	whole	whole	JJ
cord-302082-aaokc182	127	25	-	-	HYPH
cord-302082-aaokc182	127	26	cell	cell	NN
cord-302082-aaokc182	127	27	mycobacterial	mycobacterial	JJ
cord-302082-aaokc182	127	28	vaccine	vaccine	NN
cord-302082-aaokc182	127	29	(	(	-LRB-
cord-302082-aaokc182	127	30	von	von	NNP
cord-302082-aaokc182	127	31	Reyn	Reyn	NNP
cord-302082-aaokc182	127	32	et	et	FW
cord-302082-aaokc182	127	33	al	al	NNP
cord-302082-aaokc182	127	34	.	.	NNP
cord-302082-aaokc182	127	35	,	,	,
cord-302082-aaokc182	127	36	2010	2010	CD
cord-302082-aaokc182	127	37	)	)	-RRB-
cord-302082-aaokc182	127	38	.	.	.
cord-302082-aaokc182	128	1	The	the	DT
cord-302082-aaokc182	128	2	current	current	JJ
cord-302082-aaokc182	128	3	state	state	NN
cord-302082-aaokc182	128	4	of	of	IN
cord-302082-aaokc182	128	5	TB	TB	NNP
cord-302082-aaokc182	128	6	vaccine	vaccine	NN
cord-302082-aaokc182	128	7	development	development	NN
cord-302082-aaokc182	128	8	has	have	VBZ
cord-302082-aaokc182	128	9	been	be	VBN
cord-302082-aaokc182	128	10	summarised	summarise	VBN
cord-302082-aaokc182	128	11	in	in	IN
cord-302082-aaokc182	128	12	reviews	review	NNS
cord-302082-aaokc182	128	13	by	by	IN
cord-302082-aaokc182	128	14	Walker	Walker	NNP
cord-302082-aaokc182	128	15	et	et	NNP
cord-302082-aaokc182	128	16	al	al	NNP
cord-302082-aaokc182	128	17	.	.	.
cord-302082-aaokc182	129	1	(	(	-LRB-
cord-302082-aaokc182	129	2	2010	2010	CD
cord-302082-aaokc182	129	3	)	)	-RRB-
cord-302082-aaokc182	129	4	and	and	CC
cord-302082-aaokc182	129	5	Lambert	Lambert	NNP
cord-302082-aaokc182	129	6	et	et	NNP
cord-302082-aaokc182	129	7	al	al	NNP
cord-302082-aaokc182	129	8	.	.	.
cord-302082-aaokc182	130	1	(	(	-LRB-
cord-302082-aaokc182	130	2	2009	2009	CD
cord-302082-aaokc182	130	3	)	)	-RRB-
cord-302082-aaokc182	130	4	and	and	CC
cord-302082-aaokc182	130	5	examples	example	NNS
cord-302082-aaokc182	130	6	of	of	IN
cord-302082-aaokc182	130	7	vaccines	vaccine	NNS
cord-302082-aaokc182	130	8	in	in	IN
cord-302082-aaokc182	130	9	development	development	NN
cord-302082-aaokc182	130	10	are	be	VBP
cord-302082-aaokc182	130	11	shown	show	VBN
cord-302082-aaokc182	130	12	in	in	IN
cord-302082-aaokc182	130	13	Table	Table	NNP
cord-302082-aaokc182	130	14	6	6	CD
cord-302082-aaokc182	130	15	.9	.9	CD
cord-302082-aaokc182	130	16	.	.	.
cord-302082-aaokc182	131	1	Cytomegalovirus	Cytomegalovirus	NNP
cord-302082-aaokc182	131	2	,	,	,
cord-302082-aaokc182	131	3	a	a	DT
cord-302082-aaokc182	131	4	herpes	herpes	NN
cord-302082-aaokc182	131	5	virus	virus	NN
cord-302082-aaokc182	131	6	,	,	,
cord-302082-aaokc182	131	7	establishes	establish	VBZ
cord-302082-aaokc182	131	8	latent	latent	JJ
cord-302082-aaokc182	131	9	infection	infection	NN
cord-302082-aaokc182	131	10	in	in	IN
cord-302082-aaokc182	131	11	cells	cell	NNS
cord-302082-aaokc182	131	12	in	in	IN
cord-302082-aaokc182	131	13	the	the	DT
cord-302082-aaokc182	131	14	bone	bone	NN
cord-302082-aaokc182	131	15	marrow	marrow	NN
cord-302082-aaokc182	131	16	and	and	CC
cord-302082-aaokc182	131	17	peripheral	peripheral	JJ
cord-302082-aaokc182	131	18	blood	blood	NN
cord-302082-aaokc182	131	19	.	.	.
cord-302082-aaokc182	132	1	Primary	primary	JJ
cord-302082-aaokc182	132	2	infection	infection	NN
cord-302082-aaokc182	132	3	during	during	IN
cord-302082-aaokc182	132	4	pregnancy	pregnancy	NN
cord-302082-aaokc182	132	5	is	be	VBZ
cord-302082-aaokc182	132	6	associated	associate	VBN
cord-302082-aaokc182	132	7	with	with	IN
cord-302082-aaokc182	132	8	congenital	congenital	JJ
cord-302082-aaokc182	132	9	infection	infection	NN
cord-302082-aaokc182	132	10	that	that	WDT
cord-302082-aaokc182	132	11	 	 	_SP
cord-302082-aaokc182	132	12	frequently	frequently	RB
cord-302082-aaokc182	132	13	causes	cause	VBZ
cord-302082-aaokc182	132	14	a	a	DT
cord-302082-aaokc182	132	15	well	well	RB
cord-302082-aaokc182	132	16	-	-	HYPH
cord-302082-aaokc182	132	17	characterised	characterise	VBN
cord-302082-aaokc182	132	18	spectrum	spectrum	NN
cord-302082-aaokc182	132	19	of	of	IN
cord-302082-aaokc182	132	20	abnormalities	abnormality	NNS
cord-302082-aaokc182	132	21	and	and	CC
cord-302082-aaokc182	132	22	disabilities	disability	NNS
cord-302082-aaokc182	132	23	,	,	,
cord-302082-aaokc182	132	24	which	which	WDT
cord-302082-aaokc182	132	25	may	may	MD
cord-302082-aaokc182	132	26	be	be	VB
cord-302082-aaokc182	132	27	severe	severe	JJ
cord-302082-aaokc182	132	28	or	or	CC
cord-302082-aaokc182	132	29	fatal	fatal	JJ
cord-302082-aaokc182	132	30	.	.	.
cord-302082-aaokc182	133	1	Reactivation	reactivation	NN
cord-302082-aaokc182	133	2	in	in	IN
cord-302082-aaokc182	133	3	pregnancy	pregnancy	NN
cord-302082-aaokc182	133	4	is	be	VBZ
cord-302082-aaokc182	133	5	common	common	JJ
cord-302082-aaokc182	133	6	,	,	,
cord-302082-aaokc182	133	7	but	but	CC
cord-302082-aaokc182	133	8	is	be	VBZ
cord-302082-aaokc182	133	9	unlikely	unlikely	JJ
cord-302082-aaokc182	133	10	to	to	TO
cord-302082-aaokc182	133	11	cause	cause	VB
cord-302082-aaokc182	133	12	severe	severe	JJ
cord-302082-aaokc182	133	13	congenital	congenital	JJ
cord-302082-aaokc182	133	14	infection	infection	NN
cord-302082-aaokc182	133	15	,	,	,
cord-302082-aaokc182	133	16	although	although	IN
cord-302082-aaokc182	133	17	some	some	DT
cord-302082-aaokc182	133	18	manifestations	manifestation	NNS
cord-302082-aaokc182	133	19	,	,	,
cord-302082-aaokc182	133	20	especially	especially	RB
cord-302082-aaokc182	133	21	hearing	hear	VBG
cord-302082-aaokc182	133	22	loss	loss	NN
cord-302082-aaokc182	133	23	,	,	,
cord-302082-aaokc182	133	24	remain	remain	VBP
cord-302082-aaokc182	133	25	common	common	JJ
cord-302082-aaokc182	133	26	.	.	.
cord-302082-aaokc182	134	1	Reactivation	reactivation	NN
cord-302082-aaokc182	134	2	of	of	IN
cord-302082-aaokc182	134	3	CMV	CMV	NNP
cord-302082-aaokc182	134	4	is	be	VBZ
cord-302082-aaokc182	134	5	of	of	IN
cord-302082-aaokc182	134	6	special	special	JJ
cord-302082-aaokc182	134	7	concern	concern	NN
cord-302082-aaokc182	134	8	in	in	IN
cord-302082-aaokc182	134	9	immunocompromised	immunocompromised	JJ
cord-302082-aaokc182	134	10	individuals	individual	NNS
cord-302082-aaokc182	134	11	,	,	,
cord-302082-aaokc182	134	12	where	where	WRB
cord-302082-aaokc182	134	13	severe	severe	JJ
cord-302082-aaokc182	134	14	and	and	CC
cord-302082-aaokc182	134	15	fatal	fatal	JJ
cord-302082-aaokc182	134	16	pulmonary	pulmonary	JJ
cord-302082-aaokc182	134	17	,	,	,
cord-302082-aaokc182	134	18	hepatic	hepatic	JJ
cord-302082-aaokc182	134	19	and	and	CC
cord-302082-aaokc182	134	20	central	central	JJ
cord-302082-aaokc182	134	21	nervous	nervous	JJ
cord-302082-aaokc182	134	22	system	system	NN
cord-302082-aaokc182	134	23	infections	infection	NNS
cord-302082-aaokc182	134	24	are	be	VBP
cord-302082-aaokc182	134	25	common	common	JJ
cord-302082-aaokc182	134	26	.	.	.
cord-302082-aaokc182	135	1	Gastrointestinal	gastrointestinal	JJ
cord-302082-aaokc182	135	2	disease	disease	NN
cord-302082-aaokc182	135	3	and	and	CC
cord-302082-aaokc182	135	4	retinitis	retinitis	NN
cord-302082-aaokc182	135	5	are	be	VBP
cord-302082-aaokc182	135	6	common	common	JJ
cord-302082-aaokc182	135	7	in	in	IN
cord-302082-aaokc182	135	8	association	association	NN
cord-302082-aaokc182	135	9	with	with	IN
cord-302082-aaokc182	135	10	HIV	HIV	NNP
cord-302082-aaokc182	135	11	.	.	.
cord-302082-aaokc182	136	1	A	a	DT
cord-302082-aaokc182	136	2	successful	successful	JJ
cord-302082-aaokc182	136	3	CMV	CMV	NNP
cord-302082-aaokc182	136	4	vaccine	vaccine	NN
cord-302082-aaokc182	136	5	has	have	VBZ
cord-302082-aaokc182	136	6	proved	prove	VBN
cord-302082-aaokc182	136	7	elusive	elusive	JJ
cord-302082-aaokc182	136	8	for	for	IN
cord-302082-aaokc182	136	9	more	more	JJR
cord-302082-aaokc182	136	10	than	than	IN
cord-302082-aaokc182	136	11	30	30	CD
cord-302082-aaokc182	136	12	years	year	NNS
cord-302082-aaokc182	136	13	.	.	.
cord-302082-aaokc182	137	1	Based	base	VBN
cord-302082-aaokc182	137	2	upon	upon	IN
cord-302082-aaokc182	137	3	the	the	DT
cord-302082-aaokc182	137	4	observation	observation	NN
cord-302082-aaokc182	137	5	that	that	IN
cord-302082-aaokc182	137	6	antibodies	antibody	NNS
cord-302082-aaokc182	137	7	to	to	IN
cord-302082-aaokc182	137	8	the	the	DT
cord-302082-aaokc182	137	9	CMV	CMV	NNP
cord-302082-aaokc182	137	10	envelope	envelope	NN
cord-302082-aaokc182	137	11	glycoprotein	glycoprotein	NN
cord-302082-aaokc182	137	12	B	B	NNP
cord-302082-aaokc182	137	13	(	(	-LRB-
cord-302082-aaokc182	137	14	gB	gB	NNP
cord-302082-aaokc182	137	15	)	)	-RRB-
cord-302082-aaokc182	137	16	could	could	MD
cord-302082-aaokc182	137	17	Pass	pass	VB
cord-302082-aaokc182	137	18	et	et	FW
cord-302082-aaokc182	137	19	al	al	NNP
cord-302082-aaokc182	137	20	.	.	NNP
cord-302082-aaokc182	137	21	,	,	,
cord-302082-aaokc182	137	22	1999	1999	CD
cord-302082-aaokc182	137	23	)	)	-RRB-
cord-302082-aaokc182	137	24	.	.	.
cord-302082-aaokc182	138	1	A	a	DT
cord-302082-aaokc182	138	2	recent	recent	JJ
cord-302082-aaokc182	138	3	Phase	Phase	NNP
cord-302082-aaokc182	138	4	II	ii	CD
cord-302082-aaokc182	138	5	clinical	clinical	JJ
cord-302082-aaokc182	138	6	trial	trial	NN
cord-302082-aaokc182	138	7	in	in	IN
cord-302082-aaokc182	138	8	CMV	CMV	NNP
cord-302082-aaokc182	138	9	-	-	HYPH
cord-302082-aaokc182	138	10	seronegative	seronegative	JJ
cord-302082-aaokc182	138	11	women	woman	NNS
cord-302082-aaokc182	138	12	1	1	CD
cord-302082-aaokc182	138	13	year	year	NN
cord-302082-aaokc182	138	14	post	post	NN
cord-302082-aaokc182	138	15	-	-	NN
cord-302082-aaokc182	138	16	partum	partum	NNP
cord-302082-aaokc182	138	17	has	have	VBZ
cord-302082-aaokc182	138	18	shown	show	VBN
cord-302082-aaokc182	138	19	the	the	DT
cord-302082-aaokc182	138	20	potential	potential	NN
cord-302082-aaokc182	138	21	of	of	IN
cord-302082-aaokc182	138	22	gB	gB	NNP
cord-302082-aaokc182	138	23	/	/	SYM
cord-302082-aaokc182	138	24	MF59	MF59	NNP
cord-302082-aaokc182	138	25	in	in	IN
cord-302082-aaokc182	138	26	decreasing	decrease	VBG
cord-302082-aaokc182	138	27	incident	incident	NN
cord-302082-aaokc182	138	28	cases	case	NNS
cord-302082-aaokc182	138	29	of	of	IN
cord-302082-aaokc182	138	30	maternal	maternal	JJ
cord-302082-aaokc182	138	31	and	and	CC
cord-302082-aaokc182	138	32	congenital	congenital	JJ
cord-302082-aaokc182	138	33	CMV	CMV	NNP
cord-302082-aaokc182	138	34	infection	infection	NN
cord-302082-aaokc182	139	1	(	(	-LRB-
cord-302082-aaokc182	139	2	Pass	pass	VB
cord-302082-aaokc182	139	3	et	et	FW
cord-302082-aaokc182	139	4	al	al	NNP
cord-302082-aaokc182	139	5	.	.	NNP
cord-302082-aaokc182	139	6	,	,	,
cord-302082-aaokc182	139	7	2009	2009	CD
cord-302082-aaokc182	139	8	)	)	-RRB-
cord-302082-aaokc182	139	9	.	.	.
cord-302082-aaokc182	140	1	This	this	DT
cord-302082-aaokc182	140	2	is	be	VBZ
cord-302082-aaokc182	140	3	the	the	DT
cord-302082-aaokc182	140	4	first	first	JJ
cord-302082-aaokc182	140	5	evidence	evidence	NN
cord-302082-aaokc182	140	6	that	that	IN
cord-302082-aaokc182	140	7	a	a	DT
cord-302082-aaokc182	140	8	CMV	CMV	NNP
cord-302082-aaokc182	140	9	vaccine	vaccine	NN
cord-302082-aaokc182	140	10	can	can	MD
cord-302082-aaokc182	140	11	protect	protect	VB
cord-302082-aaokc182	140	12	against	against	IN
cord-302082-aaokc182	140	13	infection	infection	NN
cord-302082-aaokc182	140	14	.	.	.
cord-302082-aaokc182	141	1	An	an	DT
cord-302082-aaokc182	141	2	alternative	alternative	JJ
cord-302082-aaokc182	141	3	approach	approach	NN
cord-302082-aaokc182	141	4	to	to	IN
cord-302082-aaokc182	141	5	the	the	DT
cord-302082-aaokc182	141	6	development	development	NN
cord-302082-aaokc182	141	7	of	of	IN
cord-302082-aaokc182	141	8	a	a	DT
cord-302082-aaokc182	141	9	CMV	CMV	NNP
cord-302082-aaokc182	141	10	vaccine	vaccine	NN
cord-302082-aaokc182	141	11	has	have	VBZ
cord-302082-aaokc182	141	12	been	be	VBN
cord-302082-aaokc182	141	13	to	to	TO
cord-302082-aaokc182	141	14	utilise	utilise	VB
cord-302082-aaokc182	141	15	DNA	dna	NN
cord-302082-aaokc182	141	16	vaccination	vaccination	NN
cord-302082-aaokc182	141	17	to	to	TO
cord-302082-aaokc182	141	18	induce	induce	VB
cord-302082-aaokc182	141	19	host	host	NN
cord-302082-aaokc182	141	20	responses	response	NNS
cord-302082-aaokc182	141	21	to	to	IN
cord-302082-aaokc182	141	22	CMV	CMV	NNP
cord-302082-aaokc182	141	23	gB	gB	NNP
cord-302082-aaokc182	141	24	and	and	CC
cord-302082-aaokc182	141	25	phosphoprotein	phosphoprotein	NN
cord-302082-aaokc182	141	26	65	65	CD
cord-302082-aaokc182	142	1	(	(	-LRB-
cord-302082-aaokc182	142	2	pp65	pp65	RB
cord-302082-aaokc182	142	3	is	be	VBZ
cord-302082-aaokc182	142	4	another	another	DT
cord-302082-aaokc182	142	5	viral	viral	JJ
cord-302082-aaokc182	142	6	target	target	NN
cord-302082-aaokc182	142	7	)	)	-RRB-
cord-302082-aaokc182	142	8	.	.	.
cord-302082-aaokc182	143	1	Recent	recent	JJ
cord-302082-aaokc182	143	2	studies	study	NNS
cord-302082-aaokc182	143	3	have	have	VBP
cord-302082-aaokc182	143	4	shown	show	VBN
cord-302082-aaokc182	143	5	that	that	DT
cord-302082-aaokc182	143	6	injection	injection	NN
cord-302082-aaokc182	143	7	of	of	IN
cord-302082-aaokc182	143	8	combinations	combination	NNS
cord-302082-aaokc182	143	9	of	of	IN
cord-302082-aaokc182	143	10	plasmids	plasmid	NNS
cord-302082-aaokc182	143	11	,	,	,
cord-302082-aaokc182	143	12	formulated	formulate	VBN
cord-302082-aaokc182	143	13	with	with	IN
cord-302082-aaokc182	143	14	an	an	DT
cord-302082-aaokc182	143	15	adjuvant	adjuvant	NN
cord-302082-aaokc182	143	16	,	,	,
cord-302082-aaokc182	143	17	can	can	MD
cord-302082-aaokc182	143	18	induce	induce	VB
cord-302082-aaokc182	143	19	vaccine	vaccine	NN
cord-302082-aaokc182	143	20	-	-	HYPH
cord-302082-aaokc182	143	21	specific	specific	JJ
cord-302082-aaokc182	143	22	immune	immune	JJ
cord-302082-aaokc182	143	23	responses	response	NNS
cord-302082-aaokc182	143	24	,	,	,
cord-302082-aaokc182	143	25	and	and	CC
cord-302082-aaokc182	143	26	can	can	MD
cord-302082-aaokc182	143	27	prime	prime	VB
cord-302082-aaokc182	143	28	for	for	IN
cord-302082-aaokc182	143	29	effective	effective	JJ
cord-302082-aaokc182	143	30	memory	memory	NN
cord-302082-aaokc182	143	31	responses	response	NNS
cord-302082-aaokc182	143	32	.	.	.
cord-302082-aaokc182	144	1	The	the	DT
cord-302082-aaokc182	144	2	hallmark	hallmark	NN
cord-302082-aaokc182	144	3	of	of	IN
cord-302082-aaokc182	144	4	herpes	herpes	NNP
cord-302082-aaokc182	144	5	simplex	simplex	NNP
cord-302082-aaokc182	144	6	virus	virus	NN
cord-302082-aaokc182	144	7	types	type	NNS
cord-302082-aaokc182	144	8	1	1	CD
cord-302082-aaokc182	144	9	and	and	CC
cord-302082-aaokc182	144	10	2	2	CD
cord-302082-aaokc182	144	11	(	(	-LRB-
cord-302082-aaokc182	144	12	HSV-1	hsv-1	NN
cord-302082-aaokc182	144	13	and	and	CC
cord-302082-aaokc182	144	14	HSV-2	HSV-2	NNP
cord-302082-aaokc182	144	15	)	)	-RRB-
cord-302082-aaokc182	144	16	is	be	VBZ
cord-302082-aaokc182	144	17	their	-PRON-	PRP$
cord-302082-aaokc182	144	18	ability	ability	NN
cord-302082-aaokc182	144	19	to	to	TO
cord-302082-aaokc182	144	20	establish	establish	VB
cord-302082-aaokc182	144	21	and	and	CC
cord-302082-aaokc182	144	22	maintain	maintain	VB
cord-302082-aaokc182	144	23	latent	latent	JJ
cord-302082-aaokc182	144	24	infection	infection	NN
cord-302082-aaokc182	144	25	in	in	IN
cord-302082-aaokc182	144	26	to	to	TO
cord-302082-aaokc182	144	27	be	be	VB
cord-302082-aaokc182	144	28	exhaustive	exhaustive	JJ
cord-302082-aaokc182	144	29	but	but	CC
cord-302082-aaokc182	144	30	is	be	VBZ
cord-302082-aaokc182	144	31	intended	intend	VBN
cord-302082-aaokc182	144	32	to	to	TO
cord-302082-aaokc182	144	33	provide	provide	VB
cord-302082-aaokc182	144	34	an	an	DT
cord-302082-aaokc182	144	35	overview	overview	NN
cord-302082-aaokc182	144	36	of	of	IN
cord-302082-aaokc182	144	37	the	the	DT
cord-302082-aaokc182	144	38	subject	subject	JJ
cord-302082-aaokc182	144	39	matter	matter	NN
cord-302082-aaokc182	144	40	.	.	.
cord-302082-aaokc182	145	1	sensory	sensory	JJ
cord-302082-aaokc182	145	2	ganglion	ganglion	NN
cord-302082-aaokc182	145	3	neurons	neuron	NNS
cord-302082-aaokc182	145	4	.	.	.
cord-302082-aaokc182	146	1	Periodic	periodic	JJ
cord-302082-aaokc182	146	2	reactivation	reactivation	NN
cord-302082-aaokc182	146	3	of	of	IN
cord-302082-aaokc182	146	4	the	the	DT
cord-302082-aaokc182	146	5	latent	latent	JJ
cord-302082-aaokc182	146	6	infection	infection	NN
cord-302082-aaokc182	146	7	results	result	NNS
cord-302082-aaokc182	146	8	in	in	IN
cord-302082-aaokc182	146	9	recurrent	recurrent	JJ
cord-302082-aaokc182	146	10	infections	infection	NNS
cord-302082-aaokc182	146	11	.	.	.
cord-302082-aaokc182	147	1	Both	both	CC
cord-302082-aaokc182	147	2	HSV-1	HSV-1	NNS
cord-302082-aaokc182	147	3	and	and	CC
cord-302082-aaokc182	147	4	HSV-2	HSV-2	NNP
cord-302082-aaokc182	147	5	can	can	MD
cord-302082-aaokc182	147	6	cause	cause	VB
cord-302082-aaokc182	147	7	myriad	myriad	JJ
cord-302082-aaokc182	147	8	diseases	disease	NNS
cord-302082-aaokc182	147	9	but	but	CC
cord-302082-aaokc182	148	1	the	the	DT
cord-302082-aaokc182	148	2	greatest	great	JJS
cord-302082-aaokc182	148	3	public	public	JJ
cord-302082-aaokc182	148	4	health	health	NN
cord-302082-aaokc182	148	5	problem	problem	NN
cord-302082-aaokc182	148	6	is	be	VBZ
cord-302082-aaokc182	148	7	genital	genital	JJ
cord-302082-aaokc182	148	8	herpes	herpes	NN
cord-302082-aaokc182	148	9	.	.	.
cord-302082-aaokc182	149	1	Genital	genital	JJ
cord-302082-aaokc182	149	2	HSV-2	hsv-2	JJ
cord-302082-aaokc182	149	3	infection	infection	NN
cord-302082-aaokc182	149	4	increases	increase	VBZ
cord-302082-aaokc182	149	5	the	the	DT
cord-302082-aaokc182	149	6	risk	risk	NN
cord-302082-aaokc182	149	7	of	of	IN
cord-302082-aaokc182	149	8	HIV	HIV	NNP
cord-302082-aaokc182	149	9	acquisition	acquisition	NN
cord-302082-aaokc182	149	10	and	and	CC
cord-302082-aaokc182	149	11	transmission	transmission	NN
cord-302082-aaokc182	149	12	,	,	,
cord-302082-aaokc182	149	13	and	and	CC
cord-302082-aaokc182	149	14	control	control	NN
cord-302082-aaokc182	149	15	of	of	IN
cord-302082-aaokc182	149	16	genital	genital	JJ
cord-302082-aaokc182	149	17	herpes	herpe	NNS
cord-302082-aaokc182	149	18	has	have	VBZ
cord-302082-aaokc182	149	19	been	be	VBN
cord-302082-aaokc182	149	20	predicted	predict	VBN
cord-302082-aaokc182	149	21	to	to	TO
cord-302082-aaokc182	149	22	significantly	significantly	RB
cord-302082-aaokc182	149	23	impact	impact	VB
cord-302082-aaokc182	149	24	the	the	DT
cord-302082-aaokc182	149	25	HIV	HIV	NNP
cord-302082-aaokc182	149	26	epidemic	epidemic	NN
cord-302082-aaokc182	149	27	.	.	.
cord-302082-aaokc182	150	1	Given	give	VBN
cord-302082-aaokc182	150	2	the	the	DT
cord-302082-aaokc182	150	3	complex	complex	JJ
cord-302082-aaokc182	150	4	natural	natural	JJ
cord-302082-aaokc182	150	5	history	history	NN
cord-302082-aaokc182	150	6	of	of	IN
cord-302082-aaokc182	150	7	HSV	HSV	NNP
cord-302082-aaokc182	150	8	infections	infection	NNS
cord-302082-aaokc182	150	9	,	,	,
cord-302082-aaokc182	150	10	vaccines	vaccine	NNS
cord-302082-aaokc182	150	11	could	could	MD
cord-302082-aaokc182	150	12	have	have	VB
cord-302082-aaokc182	150	13	a	a	DT
cord-302082-aaokc182	150	14	variety	variety	NN
cord-302082-aaokc182	150	15	of	of	IN
cord-302082-aaokc182	150	16	possible	possible	JJ
cord-302082-aaokc182	150	17	risks	risk	NNS
cord-302082-aaokc182	150	18	and	and	CC
cord-302082-aaokc182	150	19	benefits	benefit	NNS
cord-302082-aaokc182	150	20	(	(	-LRB-
cord-302082-aaokc182	150	21	Table	Table	NNP
cord-302082-aaokc182	150	22	6	6	CD
cord-302082-aaokc182	150	23	.10	.10	CD
cord-302082-aaokc182	150	24	)	)	-RRB-
cord-302082-aaokc182	150	25	.	.	.
cord-302082-aaokc182	151	1	An	an	DT
cord-302082-aaokc182	151	2	effective	effective	JJ
cord-302082-aaokc182	151	3	HSV	HSV	NNP
cord-302082-aaokc182	151	4	vaccine	vaccine	NN
cord-302082-aaokc182	151	5	has	have	VBZ
cord-302082-aaokc182	151	6	been	be	VBN
cord-302082-aaokc182	151	7	sought	seek	VBN
cord-302082-aaokc182	151	8	for	for	IN
cord-302082-aaokc182	151	9	more	more	JJR
cord-302082-aaokc182	151	10	than	than	IN
cord-302082-aaokc182	151	11	80	80	CD
cord-302082-aaokc182	151	12	years	year	NNS
cord-302082-aaokc182	151	13	.	.	.
cord-302082-aaokc182	152	1	Recently	recently	RB
cord-302082-aaokc182	152	2	,	,	,
cord-302082-aaokc182	152	3	an	an	DT
cord-302082-aaokc182	152	4	HSV-2	HSV-2	NNP
cord-302082-aaokc182	152	5	glycoprotein	glycoprotein	NN
cord-302082-aaokc182	152	6	D	d	NN
cord-302082-aaokc182	152	7	(	(	-LRB-
cord-302082-aaokc182	152	8	gD2	gd2	FW
cord-302082-aaokc182	152	9	)	)	-RRB-
cord-302082-aaokc182	152	10	candidate	candidate	NN
cord-302082-aaokc182	152	11	vaccine	vaccine	NN
cord-302082-aaokc182	152	12	containing	contain	VBG
cord-302082-aaokc182	152	13	the	the	DT
cord-302082-aaokc182	152	14	AS04	AS04	NNP
cord-302082-aaokc182	152	15	adjuvant	adjuvant	NN
cord-302082-aaokc182	152	16	(	(	-LRB-
cord-302082-aaokc182	152	17	see	see	VB
cord-302082-aaokc182	152	18	Chapter	chapter	NN
cord-302082-aaokc182	152	19	4	4	CD
cord-302082-aaokc182	152	20	e	e	NN
cord-302082-aaokc182	152	21	Vaccine	vaccine	NN
cord-302082-aaokc182	152	22	adjuvants	adjuvant	NNS
cord-302082-aaokc182	152	23	)	)	-RRB-
cord-302082-aaokc182	152	24	,	,	,
cord-302082-aaokc182	152	25	was	be	VBD
cord-302082-aaokc182	152	26	tested	test	VBN
cord-302082-aaokc182	152	27	in	in	IN
cord-302082-aaokc182	152	28	three	three	CD
cord-302082-aaokc182	152	29	large	large	JJ
cord-302082-aaokc182	152	30	,	,	,
cord-302082-aaokc182	152	31	double	double	JJ
cord-302082-aaokc182	152	32	-	-	HYPH
cord-302082-aaokc182	152	33	blind	blind	JJ
cord-302082-aaokc182	152	34	,	,	,
cord-302082-aaokc182	152	35	Phase	Phase	NNP
cord-302082-aaokc182	152	36	III	III	NNP
cord-302082-aaokc182	152	37	controlled	control	VBN
cord-302082-aaokc182	152	38	trials	trial	NNS
cord-302082-aaokc182	152	39	.	.	.
cord-302082-aaokc182	153	1	The	the	DT
cord-302082-aaokc182	153	2	first	first	JJ
cord-302082-aaokc182	153	3	two	two	CD
cord-302082-aaokc182	153	4	studies	study	NNS
cord-302082-aaokc182	153	5	recruited	recruit	VBD
cord-302082-aaokc182	153	6	volunteers	volunteer	NNS
cord-302082-aaokc182	153	7	with	with	IN
cord-302082-aaokc182	153	8	a	a	DT
cord-302082-aaokc182	153	9	partner	partner	NN
cord-302082-aaokc182	153	10	with	with	IN
cord-302082-aaokc182	153	11	genital	genital	JJ
cord-302082-aaokc182	153	12	herpes	herpes	NN
cord-302082-aaokc182	153	13	disease	disease	NN
cord-302082-aaokc182	153	14	and	and	CC
cord-302082-aaokc182	153	15	found	find	VBD
cord-302082-aaokc182	153	16	the	the	DT
cord-302082-aaokc182	153	17	candidate	candidate	NN
cord-302082-aaokc182	153	18	vaccine	vaccine	NN
cord-302082-aaokc182	153	19	was	be	VBD
cord-302082-aaokc182	153	20	73	73	CD
cord-302082-aaokc182	153	21	%	%	NN
cord-302082-aaokc182	153	22	effective	effective	JJ
cord-302082-aaokc182	153	23	against	against	IN
cord-302082-aaokc182	153	24	genital	genital	JJ
cord-302082-aaokc182	153	25	herpes	herpes	NN
cord-302082-aaokc182	153	26	disease	disease	NN
cord-302082-aaokc182	153	27	in	in	IN
cord-302082-aaokc182	153	28	women	woman	NNS
cord-302082-aaokc182	153	29	seronegative	seronegative	JJ
cord-302082-aaokc182	153	30	for	for	IN
cord-302082-aaokc182	153	31	both	both	CC
cord-302082-aaokc182	153	32	HSV-1	HSV-1	NNP
cord-302082-aaokc182	153	33	and	and	CC
cord-302082-aaokc182	154	1	HSV-2	HSV-2	NNP
cord-302082-aaokc182	154	2	(	(	-LRB-
cord-302082-aaokc182	154	3	Stanberry	Stanberry	NNP
cord-302082-aaokc182	154	4	et	et	NNP
cord-302082-aaokc182	154	5	al	al	NNP
cord-302082-aaokc182	154	6	.	.	NNP
cord-302082-aaokc182	154	7	,	,	,
cord-302082-aaokc182	154	8	2002	2002	CD
cord-302082-aaokc182	154	9	)	)	-RRB-
cord-302082-aaokc182	154	10	.	.	.
cord-302082-aaokc182	155	1	Trends	trend	NNS
cord-302082-aaokc182	155	2	towards	towards	IN
cord-302082-aaokc182	155	3	protection	protection	NN
cord-302082-aaokc182	155	4	against	against	IN
cord-302082-aaokc182	155	5	infection	infection	NN
cord-302082-aaokc182	155	6	were	be	VBD
cord-302082-aaokc182	155	7	also	also	RB
cord-302082-aaokc182	155	8	observed	observe	VBN
cord-302082-aaokc182	155	9	,	,	,
cord-302082-aaokc182	155	10	but	but	CC
cord-302082-aaokc182	155	11	were	be	VBD
cord-302082-aaokc182	155	12	not	not	RB
cord-302082-aaokc182	155	13	statistically	statistically	RB
cord-302082-aaokc182	155	14	significant	significant	JJ
cord-302082-aaokc182	155	15	.	.	.
cord-302082-aaokc182	156	1	The	the	DT
cord-302082-aaokc182	156	2	candidate	candidate	NN
cord-302082-aaokc182	156	3	vaccine	vaccine	NN
cord-302082-aaokc182	156	4	was	be	VBD
cord-302082-aaokc182	156	5	not	not	RB
cord-302082-aaokc182	156	6	effective	effective	JJ
cord-302082-aaokc182	156	7	in	in	IN
cord-302082-aaokc182	156	8	HSV-1	hsv-1	NN
cord-302082-aaokc182	156	9	seropositive	seropositive	JJ
cord-302082-aaokc182	156	10	women	woman	NNS
cord-302082-aaokc182	156	11	;	;	:
cord-302082-aaokc182	156	12	or	or	CC
cord-302082-aaokc182	156	13	in	in	IN
cord-302082-aaokc182	156	14	 	 	_SP
cord-302082-aaokc182	156	15	UNDERSTANDING	understand	VBG
cord-302082-aaokc182	156	16	MODERN	modern	JJ
cord-302082-aaokc182	156	17	VACCINES	vaccine	NNS
cord-302082-aaokc182	156	18	men	man	NNS
cord-302082-aaokc182	156	19	,	,	,
cord-302082-aaokc182	156	20	regardless	regardless	RB
cord-302082-aaokc182	156	21	of	of	IN
cord-302082-aaokc182	156	22	their	-PRON-	PRP$
cord-302082-aaokc182	156	23	HSV	HSV	NNP
cord-302082-aaokc182	156	24	seropositivity	seropositivity	NN
cord-302082-aaokc182	156	25	status	status	NN
cord-302082-aaokc182	156	26	.	.	.
cord-302082-aaokc182	157	1	These	these	DT
cord-302082-aaokc182	157	2	were	be	VBD
cord-302082-aaokc182	157	3	the	the	DT
cord-302082-aaokc182	157	4	first	first	JJ
cord-302082-aaokc182	157	5	studies	study	NNS
cord-302082-aaokc182	157	6	to	to	TO
cord-302082-aaokc182	157	7	report	report	VB
cord-302082-aaokc182	157	8	a	a	DT
cord-302082-aaokc182	157	9	significant	significant	JJ
cord-302082-aaokc182	157	10	difference	difference	NN
cord-302082-aaokc182	157	11	in	in	IN
cord-302082-aaokc182	157	12	vaccine	vaccine	NN
cord-302082-aaokc182	157	13	efficacy	efficacy	NN
cord-302082-aaokc182	157	14	between	between	IN
cord-302082-aaokc182	157	15	men	man	NNS
cord-302082-aaokc182	157	16	and	and	CC
cord-302082-aaokc182	157	17	women	woman	NNS
cord-302082-aaokc182	157	18	.	.	.
cord-302082-aaokc182	158	1	This	this	DT
cord-302082-aaokc182	158	2	finding	finding	NN
cord-302082-aaokc182	158	3	could	could	MD
cord-302082-aaokc182	158	4	have	have	VB
cord-302082-aaokc182	158	5	important	important	JJ
cord-302082-aaokc182	158	6	implications	implication	NNS
cord-302082-aaokc182	158	7	for	for	IN
cord-302082-aaokc182	158	8	other	other	JJ
cord-302082-aaokc182	158	9	vaccines	vaccine	NNS
cord-302082-aaokc182	158	10	targeting	target	VBG
cord-302082-aaokc182	158	11	sexually	sexually	RB
cord-302082-aaokc182	158	12	transmitted	transmit	VBN
cord-302082-aaokc182	158	13	diseases	disease	NNS
cord-302082-aaokc182	158	14	.	.	.
cord-302082-aaokc182	159	1	The	the	DT
cord-302082-aaokc182	159	2	basis	basis	NN
cord-302082-aaokc182	159	3	for	for	IN
cord-302082-aaokc182	159	4	this	this	DT
cord-302082-aaokc182	159	5	difference	difference	NN
cord-302082-aaokc182	159	6	could	could	MD
cord-302082-aaokc182	159	7	relate	relate	VB
cord-302082-aaokc182	159	8	to	to	IN
cord-302082-aaokc182	159	9	differences	difference	NNS
cord-302082-aaokc182	159	10	in	in	IN
cord-302082-aaokc182	159	11	how	how	WRB
cord-302082-aaokc182	159	12	men	man	NNS
cord-302082-aaokc182	159	13	and	and	CC
cord-302082-aaokc182	159	14	women	woman	NNS
cord-302082-aaokc182	159	15	respond	respond	VBP
cord-302082-aaokc182	159	16	to	to	IN
cord-302082-aaokc182	159	17	novel	novel	NN
cord-302082-aaokc182	159	18	adjuvants	adjuvant	NNS
cord-302082-aaokc182	159	19	or	or	CC
cord-302082-aaokc182	159	20	may	may	MD
cord-302082-aaokc182	159	21	reflect	reflect	VB
cord-302082-aaokc182	159	22	differences	difference	NNS
cord-302082-aaokc182	159	23	in	in	IN
cord-302082-aaokc182	159	24	the	the	DT
cord-302082-aaokc182	159	25	acquisition	acquisition	NN
cord-302082-aaokc182	159	26	and	and	CC
cord-302082-aaokc182	159	27	natural	natural	JJ
cord-302082-aaokc182	159	28	history	history	NN
cord-302082-aaokc182	159	29	of	of	IN
cord-302082-aaokc182	159	30	genital	genital	JJ
cord-302082-aaokc182	159	31	herpes	herpe	NNS
cord-302082-aaokc182	159	32	in	in	IN
cord-302082-aaokc182	159	33	men	man	NNS
cord-302082-aaokc182	159	34	and	and	CC
cord-302082-aaokc182	159	35	women	woman	NNS
cord-302082-aaokc182	159	36	.	.	.
cord-302082-aaokc182	160	1	A	a	DT
cord-302082-aaokc182	160	2	third	third	JJ
cord-302082-aaokc182	160	3	Phase	Phase	NNP
cord-302082-aaokc182	160	4	III	III	NNP
cord-302082-aaokc182	160	5	efficacy	efficacy	NN
cord-302082-aaokc182	160	6	trial	trial	NN
cord-302082-aaokc182	160	7	of	of	IN
cord-302082-aaokc182	160	8	the	the	DT
cord-302082-aaokc182	160	9	gD2	gd2	FW
cord-302082-aaokc182	160	10	candidate	candidate	NN
cord-302082-aaokc182	160	11	vaccine	vaccine	NN
cord-302082-aaokc182	160	12	in	in	IN
cord-302082-aaokc182	160	13	HSV-1	HSV-1	NNP
cord-302082-aaokc182	160	14	and	and	CC
cord-302082-aaokc182	160	15	HSV-2	hsv-2	JJ
cord-302082-aaokc182	160	16	negative	negative	JJ
cord-302082-aaokc182	160	17	women	woman	NNS
cord-302082-aaokc182	160	18	who	who	WP
cord-302082-aaokc182	160	19	thought	think	VBD
cord-302082-aaokc182	160	20	themselves	-PRON-	PRP
cord-302082-aaokc182	160	21	possibly	possibly	RB
cord-302082-aaokc182	160	22	at	at	IN
cord-302082-aaokc182	160	23	risk	risk	NN
cord-302082-aaokc182	160	24	of	of	IN
cord-302082-aaokc182	160	25	acquiring	acquire	VBG
cord-302082-aaokc182	160	26	genital	genital	JJ
cord-302082-aaokc182	160	27	herpes	herpe	NNS
cord-302082-aaokc182	160	28	(	(	-LRB-
cord-302082-aaokc182	160	29	a	a	DT
cord-302082-aaokc182	160	30	different	different	JJ
cord-302082-aaokc182	160	31	risk	risk	NN
cord-302082-aaokc182	160	32	population	population	NN
cord-302082-aaokc182	160	33	than	than	IN
cord-302082-aaokc182	160	34	in	in	IN
cord-302082-aaokc182	160	35	the	the	DT
cord-302082-aaokc182	160	36	original	original	JJ
cord-302082-aaokc182	160	37	two	two	CD
cord-302082-aaokc182	160	38	trials	trial	NNS
cord-302082-aaokc182	160	39	)	)	-RRB-
cord-302082-aaokc182	160	40	has	have	VBZ
cord-302082-aaokc182	160	41	been	be	VBN
cord-302082-aaokc182	160	42	completed	complete	VBN
cord-302082-aaokc182	160	43	and	and	CC
cord-302082-aaokc182	160	44	is	be	VBZ
cord-302082-aaokc182	160	45	being	be	VBG
cord-302082-aaokc182	160	46	analysed	analyse	VBN
cord-302082-aaokc182	160	47	.	.	.
cord-302082-aaokc182	161	1	An	an	DT
cord-302082-aaokc182	161	2	initial	initial	JJ
cord-302082-aaokc182	161	3	assessment	assessment	NN
cord-302082-aaokc182	161	4	of	of	IN
cord-302082-aaokc182	161	5	the	the	DT
cord-302082-aaokc182	161	6	results	result	NNS
cord-302082-aaokc182	161	7	of	of	IN
cord-302082-aaokc182	161	8	the	the	DT
cord-302082-aaokc182	161	9	third	third	JJ
cord-302082-aaokc182	161	10	trial	trial	NN
cord-302082-aaokc182	161	11	showed	show	VBD
cord-302082-aaokc182	161	12	that	that	IN
cord-302082-aaokc182	161	13	the	the	DT
cord-302082-aaokc182	161	14	vaccine	vaccine	NN
cord-302082-aaokc182	161	15	had	have	VBD
cord-302082-aaokc182	161	16	an	an	DT
cord-302082-aaokc182	161	17	acceptable	acceptable	JJ
cord-302082-aaokc182	161	18	safety	safety	NN
cord-302082-aaokc182	161	19	profile	profile	NN
cord-302082-aaokc182	161	20	but	but	CC
cord-302082-aaokc182	161	21	the	the	DT
cord-302082-aaokc182	161	22	primary	primary	JJ
cord-302082-aaokc182	161	23	trial	trial	NN
cord-302082-aaokc182	161	24	endpoint	endpoint	NN
cord-302082-aaokc182	161	25	,	,	,
cord-302082-aaokc182	161	26	prevention	prevention	NN
cord-302082-aaokc182	161	27	of	of	IN
cord-302082-aaokc182	161	28	genital	genital	JJ
cord-302082-aaokc182	161	29	herpes	herpes	NN
cord-302082-aaokc182	161	30	disease	disease	NN
cord-302082-aaokc182	161	31	,	,	,
cord-302082-aaokc182	161	32	was	be	VBD
cord-302082-aaokc182	161	33	not	not	RB
cord-302082-aaokc182	161	34	met	meet	VBN
cord-302082-aaokc182	161	35	(	(	-LRB-
cord-302082-aaokc182	161	36	NIAID	NIAID	NNP
cord-302082-aaokc182	161	37	,	,	,
cord-302082-aaokc182	161	38	2010	2010	CD
cord-302082-aaokc182	161	39	)	)	-RRB-
cord-302082-aaokc182	161	40	.	.	.
cord-302082-aaokc182	162	1	Although	although	IN
cord-302082-aaokc182	162	2	the	the	DT
cord-302082-aaokc182	162	3	development	development	NN
cord-302082-aaokc182	162	4	of	of	IN
cord-302082-aaokc182	162	5	the	the	DT
cord-302082-aaokc182	162	6	vaccine	vaccine	NN
cord-302082-aaokc182	162	7	has	have	VBZ
cord-302082-aaokc182	162	8	been	be	VBN
cord-302082-aaokc182	162	9	stopped	stop	VBN
cord-302082-aaokc182	162	10	,	,	,
cord-302082-aaokc182	162	11	further	further	JJ
cord-302082-aaokc182	162	12	analyses	analysis	NNS
cord-302082-aaokc182	162	13	and	and	CC
cord-302082-aaokc182	162	14	comparison	comparison	NN
cord-302082-aaokc182	162	15	of	of	IN
cord-302082-aaokc182	162	16	the	the	DT
cord-302082-aaokc182	162	17	trials	trial	NNS
cord-302082-aaokc182	162	18	may	may	MD
cord-302082-aaokc182	162	19	guide	guide	VB
cord-302082-aaokc182	162	20	researchers	researcher	NNS
cord-302082-aaokc182	162	21	as	as	IN
cord-302082-aaokc182	162	22	they	-PRON-	PRP
cord-302082-aaokc182	162	23	continue	continue	VBP
cord-302082-aaokc182	162	24	seeking	seek	VBG
cord-302082-aaokc182	162	25	vaccines	vaccine	NNS
cord-302082-aaokc182	162	26	to	to	TO
cord-302082-aaokc182	162	27	control	control	VB
cord-302082-aaokc182	162	28	HSV	HSV	NNP
cord-302082-aaokc182	162	29	infections	infection	NNS
cord-302082-aaokc182	162	30	.	.	.
cord-302082-aaokc182	163	1	As	as	IN
cord-302082-aaokc182	163	2	discussed	discuss	VBN
cord-302082-aaokc182	163	3	in	in	IN
cord-302082-aaokc182	163	4	Chapter	chapter	NN
cord-302082-aaokc182	163	5	2	2	CD
cord-302082-aaokc182	163	6	e	e	NN
cord-302082-aaokc182	163	7	Vaccine	vaccine	NN
cord-302082-aaokc182	163	8	immunology	immunology	NN
cord-302082-aaokc182	163	9	,	,	,
cord-302082-aaokc182	163	10	some	some	DT
cord-302082-aaokc182	163	11	pathogens	pathogen	NNS
cord-302082-aaokc182	163	12	have	have	VBP
cord-302082-aaokc182	163	13	complex	complex	JJ
cord-302082-aaokc182	163	14	life	life	NN
cord-302082-aaokc182	163	15	cycles	cycle	NNS
cord-302082-aaokc182	163	16	.	.	.
cord-302082-aaokc182	164	1	One	one	CD
cord-302082-aaokc182	164	2	specific	specific	JJ
cord-302082-aaokc182	164	3	example	example	NN
cord-302082-aaokc182	164	4	is	be	VBZ
cord-302082-aaokc182	164	5	parasites	parasite	NNS
cord-302082-aaokc182	164	6	,	,	,
cord-302082-aaokc182	164	7	sometimes	sometimes	RB
cord-302082-aaokc182	164	8	using	use	VBG
cord-302082-aaokc182	164	9	more	more	JJR
cord-302082-aaokc182	164	10	than	than	IN
cord-302082-aaokc182	164	11	a	a	DT
cord-302082-aaokc182	164	12	single	single	JJ
cord-302082-aaokc182	164	13	host	host	NN
cord-302082-aaokc182	164	14	,	,	,
cord-302082-aaokc182	164	15	where	where	WRB
cord-302082-aaokc182	164	16	each	each	DT
cord-302082-aaokc182	164	17	development	development	NN
cord-302082-aaokc182	164	18	phase	phase	NN
cord-302082-aaokc182	164	19	is	be	VBZ
cord-302082-aaokc182	164	20	marked	mark	VBN
cord-302082-aaokc182	164	21	by	by	IN
cord-302082-aaokc182	164	22	differential	differential	JJ
cord-302082-aaokc182	164	23	expression	expression	NN
cord-302082-aaokc182	164	24	of	of	IN
cord-302082-aaokc182	164	25	major	major	JJ
cord-302082-aaokc182	164	26	proteins	protein	NNS
cord-302082-aaokc182	164	27	,	,	,
cord-302082-aaokc182	164	28	meaning	mean	VBG
cord-302082-aaokc182	164	29	that	that	IN
cord-302082-aaokc182	164	30	possible	possible	JJ
cord-302082-aaokc182	164	31	antigen	antigen	NN
cord-302082-aaokc182	164	32	targets	target	NNS
cord-302082-aaokc182	164	33	are	be	VBP
cord-302082-aaokc182	164	34	host	host	NN
cord-302082-aaokc182	164	35	-	-	:
cord-302082-aaokc182	164	36	and	and	CC
cord-302082-aaokc182	164	37	development	development	NN
cord-302082-aaokc182	164	38	-	-	HYPH
cord-302082-aaokc182	164	39	phase	phase	NN
cord-302082-aaokc182	164	40	specific	specific	NN
cord-302082-aaokc182	164	41	.	.	.
cord-302082-aaokc182	165	1	Taenid	Taenid	NNP
cord-302082-aaokc182	165	2	worms	worm	NNS
cord-302082-aaokc182	165	3	aside	aside	RB
cord-302082-aaokc182	166	1	,	,	,
cord-302082-aaokc182	166	2	vaccines	vaccine	NNS
cord-302082-aaokc182	166	3	against	against	IN
cord-302082-aaokc182	166	4	parasites	parasite	NNS
cord-302082-aaokc182	166	5	have	have	VBP
cord-302082-aaokc182	166	6	been	be	VBN
cord-302082-aaokc182	166	7	extremely	extremely	RB
cord-302082-aaokc182	166	8	difficult	difficult	JJ
cord-302082-aaokc182	166	9	to	to	TO
cord-302082-aaokc182	166	10	develop	develop	VB
cord-302082-aaokc182	166	11	and	and	CC
cord-302082-aaokc182	166	12	only	only	RB
cord-302082-aaokc182	166	13	a	a	DT
cord-302082-aaokc182	166	14	limited	limited	JJ
cord-302082-aaokc182	166	15	number	number	NN
cord-302082-aaokc182	166	16	have	have	VBP
cord-302082-aaokc182	166	17	performed	perform	VBN
cord-302082-aaokc182	166	18	well	well	RB
cord-302082-aaokc182	166	19	in	in	IN
cord-302082-aaokc182	166	20	later	later	JJ
cord-302082-aaokc182	166	21	-	-	HYPH
cord-302082-aaokc182	166	22	stage	stage	NN
cord-302082-aaokc182	166	23	clinical	clinical	JJ
cord-302082-aaokc182	166	24	trials	trial	NNS
cord-302082-aaokc182	166	25	.	.	.
cord-302082-aaokc182	167	1	The	the	DT
cord-302082-aaokc182	167	2	protozoan	protozoan	NN
cord-302082-aaokc182	167	3	parasite	parasite	VBP
cord-302082-aaokc182	167	4	Plasmodium	plasmodium	NN
cord-302082-aaokc182	167	5	falciparum	falciparum	NN
cord-302082-aaokc182	167	6	,	,	,
cord-302082-aaokc182	167	7	the	the	DT
cord-302082-aaokc182	167	8	most	most	RBS
cord-302082-aaokc182	167	9	common	common	JJ
cord-302082-aaokc182	167	10	cause	cause	NN
cord-302082-aaokc182	167	11	of	of	IN
cord-302082-aaokc182	167	12	malaria	malaria	NN
cord-302082-aaokc182	167	13	,	,	,
cord-302082-aaokc182	167	14	has	have	VBZ
cord-302082-aaokc182	167	15	a	a	DT
cord-302082-aaokc182	167	16	complex	complex	JJ
cord-302082-aaokc182	167	17	life	life	NN
cord-302082-aaokc182	167	18	cycle	cycle	NN
cord-302082-aaokc182	167	19	,	,	,
cord-302082-aaokc182	167	20	as	as	IN
cord-302082-aaokc182	167	21	shown	show	VBN
cord-302082-aaokc182	167	22	in	in	IN
cord-302082-aaokc182	167	23	Figure	Figure	NNP
cord-302082-aaokc182	167	24	6	6	CD
cord-302082-aaokc182	167	25	.7	.7	NFP
cord-302082-aaokc182	167	26	.	.	.
cord-302082-aaokc182	168	1	The	the	DT
cord-302082-aaokc182	168	2	Plasmodium	Plasmodium	NNP
cord-302082-aaokc182	168	3	parasite	parasite	NN
cord-302082-aaokc182	168	4	has	have	VBZ
cord-302082-aaokc182	168	5	a	a	DT
cord-302082-aaokc182	168	6	genome	genome	NN
cord-302082-aaokc182	168	7	encoding	encode	VBG
cord-302082-aaokc182	168	8	more	more	JJR
cord-302082-aaokc182	168	9	than	than	IN
cord-302082-aaokc182	168	10	5000	5000	CD
cord-302082-aaokc182	168	11	proteins	protein	NNS
cord-302082-aaokc182	168	12	,	,	,
cord-302082-aaokc182	168	13	and	and	CC
cord-302082-aaokc182	168	14	presents	present	VBZ
cord-302082-aaokc182	168	15	different	different	JJ
cord-302082-aaokc182	168	16	allelic	allelic	JJ
cord-302082-aaokc182	168	17	and	and	CC
cord-302082-aaokc182	168	18	immunogenic	immunogenic	JJ
cord-302082-aaokc182	168	19	Table	Table	NNP
cord-302082-aaokc182	168	20	7	7	CD
cord-302082-aaokc182	168	21	)	)	-RRB-
cord-302082-aaokc182	168	22	.	.	.
cord-302082-aaokc182	169	1	One	one	CD
cord-302082-aaokc182	169	2	of	of	IN
cord-302082-aaokc182	169	3	the	the	DT
cord-302082-aaokc182	169	4	furthest	furthest	RBS
cord-302082-aaokc182	169	5	advanced	advanced	JJ
cord-302082-aaokc182	169	6	of	of	IN
cord-302082-aaokc182	169	7	these	these	DT
cord-302082-aaokc182	169	8	new	new	JJ
cord-302082-aaokc182	169	9	candidate	candidate	NN
cord-302082-aaokc182	169	10	vaccines	vaccine	NNS
cord-302082-aaokc182	169	11	is	be	VBZ
cord-302082-aaokc182	169	12	RTS	RTS	NNP
cord-302082-aaokc182	169	13	,	,	,
cord-302082-aaokc182	169	14	S	S	NNP
cord-302082-aaokc182	169	15	/	/	SYM
cord-302082-aaokc182	169	16	AS01	AS01	NNP
cord-302082-aaokc182	169	17	.	.	.
cord-302082-aaokc182	170	1	The	the	DT
cord-302082-aaokc182	170	2	vaccine	vaccine	NN
cord-302082-aaokc182	170	3	targets	target	VBZ
cord-302082-aaokc182	170	4	the	the	DT
cord-302082-aaokc182	170	5	pre	pre	JJ
cord-302082-aaokc182	170	6	-	-	JJ
cord-302082-aaokc182	170	7	erythrocytic	erythrocytic	JJ
cord-302082-aaokc182	170	8	stage	stage	NN
cord-302082-aaokc182	170	9	of	of	IN
cord-302082-aaokc182	170	10	the	the	DT
cord-302082-aaokc182	170	11	parasite	parasite	NN
cord-302082-aaokc182	170	12	(	(	-LRB-
cord-302082-aaokc182	170	13	Figure	figure	NN
cord-302082-aaokc182	170	14	6.7	6.7	CD
cord-302082-aaokc182	170	15	)	)	-RRB-
cord-302082-aaokc182	170	16	.	.	.
cord-302082-aaokc182	171	1	To	to	TO
cord-302082-aaokc182	171	2	be	be	VB
cord-302082-aaokc182	171	3	protective	protective	JJ
cord-302082-aaokc182	171	4	,	,	,
cord-302082-aaokc182	171	5	a	a	DT
cord-302082-aaokc182	171	6	vaccine	vaccine	NN
cord-302082-aaokc182	171	7	targeted	target	VBN
cord-302082-aaokc182	171	8	at	at	IN
cord-302082-aaokc182	171	9	this	this	DT
cord-302082-aaokc182	171	10	phase	phase	NN
cord-302082-aaokc182	171	11	needs	need	VBZ
cord-302082-aaokc182	171	12	to	to	TO
cord-302082-aaokc182	171	13	induce	induce	VB
cord-302082-aaokc182	171	14	humoral	humoral	JJ
cord-302082-aaokc182	171	15	immunity	immunity	NN
cord-302082-aaokc182	171	16	,	,	,
cord-302082-aaokc182	171	17	to	to	TO
cord-302082-aaokc182	171	18	prevent	prevent	VB
cord-302082-aaokc182	171	19	parasites	parasite	NNS
cord-302082-aaokc182	171	20	from	from	IN
cord-302082-aaokc182	171	21	invading	invade	VBG
cord-302082-aaokc182	171	22	the	the	DT
cord-302082-aaokc182	171	23	liver	liver	NN
cord-302082-aaokc182	171	24	,	,	,
cord-302082-aaokc182	171	25	and	and	CC
cord-302082-aaokc182	171	26	cell	cell	NN
cord-302082-aaokc182	171	27	-	-	HYPH
cord-302082-aaokc182	171	28	mediated	mediate	VBN
cord-302082-aaokc182	171	29	immunity	immunity	NN
cord-302082-aaokc182	171	30	to	to	TO
cord-302082-aaokc182	171	31	destroy	destroy	VB
cord-302082-aaokc182	171	32	hepatocytes	hepatocyte	NNS
cord-302082-aaokc182	171	33	that	that	WDT
cord-302082-aaokc182	171	34	become	become	VBP
cord-302082-aaokc182	171	35	infected	infect	VBN
cord-302082-aaokc182	171	36	in	in	IN
cord-302082-aaokc182	171	37	the	the	DT
cord-302082-aaokc182	171	38	face	face	NN
cord-302082-aaokc182	171	39	of	of	IN
cord-302082-aaokc182	171	40	the	the	DT
cord-302082-aaokc182	171	41	humoral	humoral	JJ
cord-302082-aaokc182	171	42	immune	immune	JJ
cord-302082-aaokc182	171	43	response	response	NN
cord-302082-aaokc182	171	44	.	.	.
cord-302082-aaokc182	172	1	The	the	DT
cord-302082-aaokc182	172	2	RTS	RTS	NNP
cord-302082-aaokc182	172	3	,	,	,
cord-302082-aaokc182	172	4	S	S	NNP
cord-302082-aaokc182	172	5	antigen	antigen	NN
cord-302082-aaokc182	172	6	,	,	,
cord-302082-aaokc182	172	7	produced	produce	VBN
cord-302082-aaokc182	172	8	in	in	IN
cord-302082-aaokc182	172	9	Saccharomyces	Saccharomyces	NNP
cord-302082-aaokc182	172	10	cerevisiae	cerevisiae	NNS
cord-302082-aaokc182	172	11	,	,	,
cord-302082-aaokc182	172	12	contains	contain	VBZ
cord-302082-aaokc182	172	13	sequences	sequence	NNS
cord-302082-aaokc182	172	14	of	of	IN
cord-302082-aaokc182	172	15	the	the	DT
cord-302082-aaokc182	172	16	P.	P.	NNP
cord-302082-aaokc182	172	17	falciparum	falciparum	NN
cord-302082-aaokc182	172	18	circumsporozoite	circumsporozoite	JJ
cord-302082-aaokc182	172	19	protein	protein	NN
cord-302082-aaokc182	172	20	,	,	,
cord-302082-aaokc182	172	21	linked	link	VBN
cord-302082-aaokc182	172	22	to	to	IN
cord-302082-aaokc182	172	23	the	the	DT
cord-302082-aaokc182	172	24	hepatitis	hepatitis	NN
cord-302082-aaokc182	172	25	B	B	NNP
cord-302082-aaokc182	172	26	surface	surface	NN
cord-302082-aaokc182	172	27	antigen	antigen	NN
cord-302082-aaokc182	172	28	(	(	-LRB-
cord-302082-aaokc182	172	29	HBsAg	hbsag	ADD
cord-302082-aaokc182	172	30	)	)	-RRB-
cord-302082-aaokc182	172	31	.	.	.
cord-302082-aaokc182	173	1	This	this	DT
cord-302082-aaokc182	173	2	chimeric	chimeric	JJ
cord-302082-aaokc182	173	3	protein	protein	NN
cord-302082-aaokc182	173	4	spontaneously	spontaneously	RB
cord-302082-aaokc182	173	5	assembles	assemble	VBZ
cord-302082-aaokc182	173	6	into	into	IN
cord-302082-aaokc182	173	7	mixed	mixed	JJ
cord-302082-aaokc182	173	8	polymeric	polymeric	JJ
cord-302082-aaokc182	173	9	particulate	particulate	NN
cord-302082-aaokc182	173	10	structures	structure	NNS
cord-302082-aaokc182	173	11	.	.	.
cord-302082-aaokc182	174	1	In	in	IN
cord-302082-aaokc182	174	2	Phase	Phase	NNP
cord-302082-aaokc182	174	3	II	II	NNP
cord-302082-aaokc182	174	4	studies	study	NNS
cord-302082-aaokc182	174	5	,	,	,
cord-302082-aaokc182	174	6	the	the	DT
cord-302082-aaokc182	174	7	RTS	RTS	NNP
cord-302082-aaokc182	174	8	,	,	,
cord-302082-aaokc182	174	9	S	S	NNP
cord-302082-aaokc182	174	10	/	/	SYM
cord-302082-aaokc182	174	11	AS01	AS01	NNP
cord-302082-aaokc182	174	12	candidate	candidate	NN
cord-302082-aaokc182	174	13	vaccine	vaccine	NN
cord-302082-aaokc182	174	14	induced	induce	VBD
cord-302082-aaokc182	174	15	a	a	DT
cord-302082-aaokc182	174	16	strong	strong	JJ
cord-302082-aaokc182	174	17	neutralising	neutralise	VBG
cord-302082-aaokc182	174	18	antibody	antibody	NN
cord-302082-aaokc182	174	19	response	response	NN
cord-302082-aaokc182	174	20	and	and	CC
cord-302082-aaokc182	174	21	cell	cell	NN
cord-302082-aaokc182	174	22	-	-	HYPH
cord-302082-aaokc182	174	23	mediated	mediate	VBN
cord-302082-aaokc182	174	24	immunity	immunity	NN
cord-302082-aaokc182	174	25	,	,	,
cord-302082-aaokc182	174	26	and	and	CC
cord-302082-aaokc182	174	27	afforded	afford	VBN
cord-302082-aaokc182	174	28	protection	protection	NN
cord-302082-aaokc182	174	29	against	against	IN
cord-302082-aaokc182	174	30	malaria	malaria	NN
cord-302082-aaokc182	175	1	(	(	-LRB-
cord-302082-aaokc182	175	2	Bejon	Bejon	NNP
cord-302082-aaokc182	175	3	et	et	NNP
cord-302082-aaokc182	175	4	al	al	NNP
cord-302082-aaokc182	175	5	.	.	NNP
cord-302082-aaokc182	175	6	,	,	,
cord-302082-aaokc182	175	7	2008	2008	CD
cord-302082-aaokc182	176	1	;	;	:
cord-302082-aaokc182	176	2	Abdulla	Abdulla	NNP
cord-302082-aaokc182	176	3	et	et	NNP
cord-302082-aaokc182	176	4	al	al	NNP
cord-302082-aaokc182	176	5	.	.	NNP
cord-302082-aaokc182	176	6	,	,	,
cord-302082-aaokc182	176	7	2008	2008	CD
cord-302082-aaokc182	176	8	)	)	-RRB-
cord-302082-aaokc182	176	9	.	.	.
cord-302082-aaokc182	177	1	RTS	RTS	NNP
cord-302082-aaokc182	177	2	,	,	,
cord-302082-aaokc182	178	1	S	S	NNP
cord-302082-aaokc182	178	2	/	/	SYM
cord-302082-aaokc182	178	3	AS01	AS01	NNP
cord-302082-aaokc182	178	4	has	have	VBZ
cord-302082-aaokc182	178	5	been	be	VBN
cord-302082-aaokc182	178	6	selected	select	VBN
cord-302082-aaokc182	178	7	to	to	TO
cord-302082-aaokc182	178	8	proceed	proceed	VB
cord-302082-aaokc182	178	9	to	to	IN
cord-302082-aaokc182	178	10	Phase	Phase	NNP
cord-302082-aaokc182	178	11	III	iii	CD
cord-302082-aaokc182	178	12	clinical	clinical	JJ
cord-302082-aaokc182	178	13	testing	testing	NN
cord-302082-aaokc182	178	14	due	due	IN
cord-302082-aaokc182	178	15	to	to	IN
cord-302082-aaokc182	178	16	its	-PRON-	PRP$
cord-302082-aaokc182	178	17	higher	high	JJR
cord-302082-aaokc182	178	18	efficacy	efficacy	NN
cord-302082-aaokc182	178	19	compared	compare	VBN
cord-302082-aaokc182	178	20	with	with	IN
cord-302082-aaokc182	178	21	alternative	alternative	JJ
cord-302082-aaokc182	178	22	formulations	formulation	NNS
cord-302082-aaokc182	178	23	.	.	.
cord-302082-aaokc182	179	1	If	if	IN
cord-302082-aaokc182	179	2	successful	successful	JJ
cord-302082-aaokc182	179	3	,	,	,
cord-302082-aaokc182	179	4	the	the	DT
cord-302082-aaokc182	179	5	RTS	RTS	NNP
cord-302082-aaokc182	179	6	,	,	,
cord-302082-aaokc182	179	7	S	S	NNP
cord-302082-aaokc182	179	8	/	/	SYM
cord-302082-aaokc182	179	9	AS01	AS01	NNP
cord-302082-aaokc182	179	10	candidate	candidate	NN
cord-302082-aaokc182	179	11	vaccine	vaccine	NN
cord-302082-aaokc182	179	12	could	could	MD
cord-302082-aaokc182	179	13	be	be	VB
cord-302082-aaokc182	179	14	the	the	DT
cord-302082-aaokc182	179	15	first	first	JJ
cord-302082-aaokc182	179	16	licensed	licensed	JJ
cord-302082-aaokc182	179	17	human	human	JJ
cord-302082-aaokc182	179	18	vaccine	vaccine	NN
cord-302082-aaokc182	179	19	against	against	IN
cord-302082-aaokc182	179	20	a	a	DT
cord-302082-aaokc182	179	21	parasite	parasite	NN
cord-302082-aaokc182	179	22	.	.	.
cord-302082-aaokc182	180	1	Other	other	JJ
cord-302082-aaokc182	180	2	malaria	malaria	NN
cord-302082-aaokc182	180	3	candidate	candidate	NN
cord-302082-aaokc182	180	4	vaccines	vaccine	NNS
cord-302082-aaokc182	180	5	in	in	IN
cord-302082-aaokc182	180	6	development	development	NN
cord-302082-aaokc182	180	7	are	be	VBP
cord-302082-aaokc182	180	8	shown	show	VBN
cord-302082-aaokc182	180	9	in	in	IN
cord-302082-aaokc182	180	10	Appendices	Appendices	NNPS
cord-302082-aaokc182	180	11	,	,	,
cord-302082-aaokc182	180	12	Supplementary	Supplementary	NNP
cord-302082-aaokc182	180	13	Table	Table	NNP
cord-302082-aaokc182	180	14	7	7	CD
cord-302082-aaokc182	180	15	.	.	.
cord-302082-aaokc182	181	1	Pathogens	pathogen	NNS
cord-302082-aaokc182	181	2	may	may	MD
cord-302082-aaokc182	181	3	mutate	mutate	VB
cord-302082-aaokc182	181	4	or	or	CC
cord-302082-aaokc182	181	5	recombine	recombine	VB
cord-302082-aaokc182	181	6	to	to	TO
cord-302082-aaokc182	181	7	change	change	VB
cord-302082-aaokc182	181	8	their	-PRON-	PRP$
cord-302082-aaokc182	181	9	antigenic	antigenic	JJ
cord-302082-aaokc182	181	10	profile	profile	NN
cord-302082-aaokc182	181	11	.	.	.
cord-302082-aaokc182	182	1	Antigenic	antigenic	JJ
cord-302082-aaokc182	182	2	drift	drift	NN
cord-302082-aaokc182	182	3	refers	refer	VBZ
cord-302082-aaokc182	182	4	to	to	IN
cord-302082-aaokc182	182	5	a	a	DT
cord-302082-aaokc182	182	6	gradual	gradual	JJ
cord-302082-aaokc182	182	7	process	process	NN
cord-302082-aaokc182	182	8	whereby	whereby	WRB
cord-302082-aaokc182	182	9	point	point	NN
cord-302082-aaokc182	182	10	mutations	mutation	NNS
cord-302082-aaokc182	182	11	in	in	IN
cord-302082-aaokc182	182	12	genes	gene	NNS
cord-302082-aaokc182	182	13	encoding	encode	VBG
cord-302082-aaokc182	182	14	antigenic	antigenic	JJ
cord-302082-aaokc182	182	15	proteins	protein	NNS
cord-302082-aaokc182	182	16	change	change	VBP
cord-302082-aaokc182	182	17	the	the	DT
cord-302082-aaokc182	182	18	antigen	antigen	NN
cord-302082-aaokc182	182	19	sufficiently	sufficiently	RB
cord-302082-aaokc182	182	20	so	so	IN
cord-302082-aaokc182	182	21	that	that	IN
cord-302082-aaokc182	182	22	over	over	IN
cord-302082-aaokc182	182	23	time	time	NN
cord-302082-aaokc182	182	24	previously	previously	RB
cord-302082-aaokc182	182	25	effective	effective	JJ
cord-302082-aaokc182	182	26	antibodies	antibody	NNS
cord-302082-aaokc182	182	27	and	and	CC
cord-302082-aaokc182	182	28	vaccines	vaccine	NNS
cord-302082-aaokc182	182	29	no	no	RB
cord-302082-aaokc182	182	30	longer	long	RBR
cord-302082-aaokc182	182	31	effectively	effectively	RB
cord-302082-aaokc182	182	32	control	control	VB
cord-302082-aaokc182	182	33	the	the	DT
cord-302082-aaokc182	182	34	pathogen	pathogen	NN
cord-302082-aaokc182	182	35	and	and	CC
cord-302082-aaokc182	182	36	hence	hence	RB
cord-302082-aaokc182	182	37	new	new	JJ
cord-302082-aaokc182	182	38	vaccines	vaccine	NNS
cord-302082-aaokc182	183	1	need	need	VB
cord-302082-aaokc182	183	2	to	to	TO
cord-302082-aaokc182	183	3	be	be	VB
cord-302082-aaokc182	183	4	created	create	VBN
cord-302082-aaokc182	183	5	.	.	.
cord-302082-aaokc182	184	1	Antigenic	antigenic	JJ
cord-302082-aaokc182	184	2	shift	shift	NN
cord-302082-aaokc182	184	3	is	be	VBZ
cord-302082-aaokc182	184	4	a	a	DT
cord-302082-aaokc182	184	5	more	more	RBR
cord-302082-aaokc182	184	6	dramatic	dramatic	JJ
cord-302082-aaokc182	184	7	event	event	NN
cord-302082-aaokc182	184	8	where	where	WRB
cord-302082-aaokc182	184	9	there	there	EX
cord-302082-aaokc182	184	10	is	be	VBZ
cord-302082-aaokc182	184	11	a	a	DT
cord-302082-aaokc182	184	12	recombination	recombination	NN
cord-302082-aaokc182	184	13	of	of	IN
cord-302082-aaokc182	184	14	genes	gene	NNS
cord-302082-aaokc182	184	15	between	between	IN
cord-302082-aaokc182	184	16	different	different	JJ
cord-302082-aaokc182	184	17	pathogen	pathogen	NN
cord-302082-aaokc182	184	18	strains	strain	NNS
cord-302082-aaokc182	184	19	that	that	WDT
cord-302082-aaokc182	184	20	gives	give	VBZ
cord-302082-aaokc182	184	21	rise	rise	NN
cord-302082-aaokc182	184	22	to	to	IN
cord-302082-aaokc182	184	23	a	a	DT
cord-302082-aaokc182	184	24	new	new	JJ
cord-302082-aaokc182	184	25	strain	strain	NN
cord-302082-aaokc182	184	26	with	with	IN
cord-302082-aaokc182	184	27	a	a	DT
cord-302082-aaokc182	184	28	unique	unique	JJ
cord-302082-aaokc182	184	29	antigenic	antigenic	JJ
cord-302082-aaokc182	184	30	profile	profile	NN
cord-302082-aaokc182	184	31	.	.	.
cord-302082-aaokc182	185	1	In	in	IN
cord-302082-aaokc182	185	2	theory	theory	NN
cord-302082-aaokc182	185	3	,	,	,
cord-302082-aaokc182	185	4	pathogens	pathogen	NNS
cord-302082-aaokc182	185	5	are	be	VBP
cord-302082-aaokc182	185	6	susceptible	susceptible	JJ
cord-302082-aaokc182	185	7	to	to	IN
cord-302082-aaokc182	185	8	selective	selective	JJ
cord-302082-aaokc182	185	9	pressure	pressure	NN
cord-302082-aaokc182	185	10	and	and	CC
cord-302082-aaokc182	185	11	an	an	DT
cord-302082-aaokc182	185	12	immunological	immunological	JJ
cord-302082-aaokc182	185	13	environment	environment	NN
cord-302082-aaokc182	185	14	that	that	WDT
cord-302082-aaokc182	185	15	provides	provide	VBZ
cord-302082-aaokc182	185	16	strong	strong	JJ
cord-302082-aaokc182	185	17	selective	selective	JJ
cord-302082-aaokc182	185	18	pressures	pressure	NNS
cord-302082-aaokc182	185	19	should	should	MD
cord-302082-aaokc182	185	20	provide	provide	VB
cord-302082-aaokc182	185	21	the	the	DT
cord-302082-aaokc182	185	22	'	'	``
cord-302082-aaokc182	185	23	bottleneck	bottleneck	NN
cord-302082-aaokc182	185	24	'	'	''
cord-302082-aaokc182	185	25	that	that	WDT
cord-302082-aaokc182	185	26	drives	drive	VBZ
cord-302082-aaokc182	185	27	selection	selection	NN
cord-302082-aaokc182	185	28	.	.	.
cord-302082-aaokc182	186	1	This	this	DT
cord-302082-aaokc182	186	2	occurs	occur	VBZ
cord-302082-aaokc182	186	3	with	with	IN
cord-302082-aaokc182	186	4	influenza	influenza	NN
cord-302082-aaokc182	186	5	viruses	virus	NNS
cord-302082-aaokc182	186	6	,	,	,
cord-302082-aaokc182	186	7	where	where	WRB
cord-302082-aaokc182	186	8	the	the	DT
cord-302082-aaokc182	186	9	high	high	JJ
cord-302082-aaokc182	186	10	mutation	mutation	NN
cord-302082-aaokc182	186	11	frequency	frequency	NN
cord-302082-aaokc182	186	12	allows	allow	VBZ
cord-302082-aaokc182	186	13	for	for	IN
cord-302082-aaokc182	186	14	the	the	DT
cord-302082-aaokc182	186	15	selection	selection	NN
cord-302082-aaokc182	186	16	of	of	IN
cord-302082-aaokc182	186	17	mutants	mutant	NNS
cord-302082-aaokc182	186	18	that	that	WDT
cord-302082-aaokc182	186	19	are	be	VBP
cord-302082-aaokc182	186	20	not	not	RB
cord-302082-aaokc182	186	21	neutralised	neutralise	VBN
cord-302082-aaokc182	186	22	.	.	.
cord-302082-aaokc182	187	1	The	the	DT
cord-302082-aaokc182	187	2	risk	risk	NN
cord-302082-aaokc182	187	3	of	of	IN
cord-302082-aaokc182	187	4	vaccine	vaccine	NN
cord-302082-aaokc182	187	5	-	-	HYPH
cord-302082-aaokc182	187	6	mediated	mediate	VBN
cord-302082-aaokc182	187	7	immune	immune	JJ
cord-302082-aaokc182	187	8	selection	selection	NN
cord-302082-aaokc182	187	9	of	of	IN
cord-302082-aaokc182	187	10	pathogens	pathogen	NNS
cord-302082-aaokc182	187	11	,	,	,
cord-302082-aaokc182	187	12	though	though	IN
cord-302082-aaokc182	187	13	certainly	certainly	RB
cord-302082-aaokc182	187	14	present	present	JJ
cord-302082-aaokc182	187	15	,	,	,
cord-302082-aaokc182	187	16	is	be	VBZ
cord-302082-aaokc182	187	17	difficult	difficult	JJ
cord-302082-aaokc182	187	18	to	to	TO
cord-302082-aaokc182	187	19	demonstrate	demonstrate	VB
cord-302082-aaokc182	187	20	.	.	.
cord-302082-aaokc182	188	1	Moreover	moreover	RB
cord-302082-aaokc182	188	2	,	,	,
cord-302082-aaokc182	188	3	peptide	peptide	JJ
cord-302082-aaokc182	188	4	vaccines	vaccine	NNS
cord-302082-aaokc182	188	5	only	only	RB
cord-302082-aaokc182	188	6	use	use	VBP
cord-302082-aaokc182	188	7	the	the	DT
cord-302082-aaokc182	188	8	antigenic	antigenic	JJ
cord-302082-aaokc182	188	9	epitope	epitope	NN
cord-302082-aaokc182	188	10	so	so	IN
cord-302082-aaokc182	188	11	the	the	DT
cord-302082-aaokc182	188	12	risk	risk	NN
cord-302082-aaokc182	188	13	of	of	IN
cord-302082-aaokc182	188	14	pathogen	pathogen	NN
cord-302082-aaokc182	188	15	evolution	evolution	NN
cord-302082-aaokc182	188	16	is	be	VBZ
cord-302082-aaokc182	188	17	theoretically	theoretically	RB
cord-302082-aaokc182	188	18	increased	increase	VBN
cord-302082-aaokc182	188	19	.	.	.
cord-302082-aaokc182	189	1	However	however	RB
cord-302082-aaokc182	189	2	,	,	,
cord-302082-aaokc182	189	3	this	this	DT
cord-302082-aaokc182	189	4	phenomenon	phenomenon	NN
cord-302082-aaokc182	189	5	has	have	VBZ
cord-302082-aaokc182	189	6	not	not	RB
cord-302082-aaokc182	189	7	been	be	VBN
cord-302082-aaokc182	189	8	regularly	regularly	RB
cord-302082-aaokc182	189	9	observed	observe	VBN
cord-302082-aaokc182	189	10	in	in	IN
cord-302082-aaokc182	189	11	experimental	experimental	JJ
cord-302082-aaokc182	189	12	studies	study	NNS
cord-302082-aaokc182	189	13	and	and	CC
cord-302082-aaokc182	189	14	may	may	MD
cord-302082-aaokc182	189	15	reflect	reflect	VB
cord-302082-aaokc182	189	16	the	the	DT
cord-302082-aaokc182	189	17	complex	complex	JJ
cord-302082-aaokc182	189	18	nature	nature	NN
cord-302082-aaokc182	189	19	of	of	IN
cord-302082-aaokc182	189	20	most	most	JJS
cord-302082-aaokc182	189	21	vaccine	vaccine	NN
cord-302082-aaokc182	189	22	antigens	antigen	NNS
cord-302082-aaokc182	189	23	and	and	CC
cord-302082-aaokc182	189	24	the	the	DT
cord-302082-aaokc182	189	25	presence	presence	NN
cord-302082-aaokc182	189	26	of	of	IN
cord-302082-aaokc182	189	27	immune	immune	JJ
cord-302082-aaokc182	189	28	responses	response	NNS
cord-302082-aaokc182	189	29	against	against	IN
cord-302082-aaokc182	189	30	multiple	multiple	JJ
cord-302082-aaokc182	189	31	antigens	antigen	NNS
cord-302082-aaokc182	189	32	and	and	CC
cord-302082-aaokc182	189	33	multiple	multiple	JJ
cord-302082-aaokc182	189	34	epitopes	epitope	NNS
cord-302082-aaokc182	189	35	within	within	IN
cord-302082-aaokc182	189	36	antigens	antigen	NNS
cord-302082-aaokc182	189	37	.	.	.
cord-302082-aaokc182	190	1	Serotype	Serotype	NNP
cord-302082-aaokc182	190	2	replacement	replacement	NN
cord-302082-aaokc182	190	3	,	,	,
cord-302082-aaokc182	190	4	where	where	WRB
cord-302082-aaokc182	190	5	the	the	DT
cord-302082-aaokc182	190	6	distribution	distribution	NN
cord-302082-aaokc182	190	7	of	of	IN
cord-302082-aaokc182	190	8	specific	specific	JJ
cord-302082-aaokc182	190	9	microbial	microbial	JJ
cord-302082-aaokc182	190	10	serotypes	serotypes	NN
cord-302082-aaokc182	190	11	within	within	IN
cord-302082-aaokc182	190	12	communities	community	NNS
cord-302082-aaokc182	190	13	changes	change	NNS
cord-302082-aaokc182	190	14	after	after	IN
cord-302082-aaokc182	190	15	the	the	DT
cord-302082-aaokc182	190	16	introduction	introduction	NN
cord-302082-aaokc182	190	17	of	of	IN
cord-302082-aaokc182	190	18	vaccines	vaccine	NNS
cord-302082-aaokc182	190	19	,	,	,
cord-302082-aaokc182	190	20	has	have	VBZ
cord-302082-aaokc182	190	21	occurred	occur	VBN
cord-302082-aaokc182	190	22	for	for	IN
cord-302082-aaokc182	190	23	some	some	DT
cord-302082-aaokc182	190	24	bacterial	bacterial	JJ
cord-302082-aaokc182	190	25	pathogens	pathogen	NNS
cord-302082-aaokc182	190	26	and	and	CC
cord-302082-aaokc182	190	27	may	may	MD
cord-302082-aaokc182	190	28	be	be	VB
cord-302082-aaokc182	190	29	a	a	DT
cord-302082-aaokc182	190	30	consequence	consequence	NN
cord-302082-aaokc182	190	31	of	of	IN
cord-302082-aaokc182	190	32	the	the	DT
cord-302082-aaokc182	190	33	use	use	NN
cord-302082-aaokc182	190	34	of	of	IN
cord-302082-aaokc182	190	35	capsular	capsular	JJ
cord-302082-aaokc182	190	36	vaccines	vaccine	NNS
cord-302082-aaokc182	190	37	that	that	WDT
cord-302082-aaokc182	190	38	address	address	VBP
cord-302082-aaokc182	190	39	only	only	RB
cord-302082-aaokc182	190	40	a	a	DT
cord-302082-aaokc182	190	41	limited	limited	JJ
cord-302082-aaokc182	190	42	number	number	NN
cord-302082-aaokc182	190	43	of	of	IN
cord-302082-aaokc182	190	44	serotypes	serotype	NNS
cord-302082-aaokc182	190	45	.	.	.
cord-302082-aaokc182	191	1	Similarly	similarly	RB
cord-302082-aaokc182	191	2	,	,	,
cord-302082-aaokc182	191	3	since	since	IN
cord-302082-aaokc182	191	4	their	-PRON-	PRP$
cord-302082-aaokc182	191	5	introduction	introduction	NN
cord-302082-aaokc182	191	6	in	in	IN
cord-302082-aaokc182	191	7	the	the	DT
cord-302082-aaokc182	191	8	1940s	1940	NNS
cord-302082-aaokc182	191	9	,	,	,
cord-302082-aaokc182	191	10	the	the	DT
cord-302082-aaokc182	191	11	use	use	NN
cord-302082-aaokc182	191	12	of	of	IN
cord-302082-aaokc182	191	13	antibiotics	antibiotic	NNS
cord-302082-aaokc182	191	14	has	have	VBZ
cord-302082-aaokc182	191	15	exerted	exert	VBN
cord-302082-aaokc182	191	16	a	a	DT
cord-302082-aaokc182	191	17	selective	selective	JJ
cord-302082-aaokc182	191	18	pressure	pressure	NN
cord-302082-aaokc182	191	19	on	on	IN
cord-302082-aaokc182	191	20	bacterial	bacterial	JJ
cord-302082-aaokc182	191	21	strains	strain	NNS
cord-302082-aaokc182	191	22	leading	lead	VBG
cord-302082-aaokc182	191	23	to	to	IN
cord-302082-aaokc182	191	24	selection	selection	NN
cord-302082-aaokc182	191	25	for	for	IN
cord-302082-aaokc182	191	26	common	common	JJ
cord-302082-aaokc182	191	27	resistance	resistance	NN
cord-302082-aaokc182	191	28	alleles	allele	NNS
cord-302082-aaokc182	191	29	(	(	-LRB-
cord-302082-aaokc182	191	30	eg	eg	IN
cord-302082-aaokc182	191	31	the	the	DT
cord-302082-aaokc182	191	32	extended	extend	VBN
cord-302082-aaokc182	191	33	-	-	HYPH
cord-302082-aaokc182	191	34	spectrum	spectrum	NN
cord-302082-aaokc182	191	35	beta	beta	NN
cord-302082-aaokc182	191	36	-	-	HYPH
cord-302082-aaokc182	191	37	lactamase	lactamase	NN
cord-302082-aaokc182	191	38	[	[	-LRB-
cord-302082-aaokc182	191	39	ESBL	ESBL	NNP
cord-302082-aaokc182	191	40	]	]	-RRB-
cord-302082-aaokc182	191	41	resistance	resistance	NN
cord-302082-aaokc182	191	42	of	of	IN
cord-302082-aaokc182	191	43	enteric	enteric	JJ
cord-302082-aaokc182	191	44	bacteria	bacteria	NNS
cord-302082-aaokc182	191	45	and	and	CC
cord-302082-aaokc182	191	46	beta	beta	NN
cord-302082-aaokc182	191	47	-	-	HYPH
cord-302082-aaokc182	191	48	lactamase	lactamase	NN
cord-302082-aaokc182	191	49	resistance	resistance	NN
cord-302082-aaokc182	191	50	in	in	IN
cord-302082-aaokc182	191	51	gonococci	gonococci	NNP
cord-302082-aaokc182	191	52	)	)	-RRB-
cord-302082-aaokc182	191	53	.	.	.
cord-302082-aaokc182	192	1	To	to	IN
cord-302082-aaokc182	192	2	date	date	NN
cord-302082-aaokc182	192	3	,	,	,
cord-302082-aaokc182	192	4	there	there	EX
cord-302082-aaokc182	192	5	has	have	VBZ
cord-302082-aaokc182	192	6	been	be	VBN
cord-302082-aaokc182	192	7	no	no	DT
cord-302082-aaokc182	192	8	requirement	requirement	NN
cord-302082-aaokc182	192	9	to	to	TO
cord-302082-aaokc182	192	10	remodel	remodel	VB
cord-302082-aaokc182	192	11	a	a	DT
cord-302082-aaokc182	192	12	vaccine	vaccine	NN
cord-302082-aaokc182	192	13	because	because	IN
cord-302082-aaokc182	192	14	of	of	IN
cord-302082-aaokc182	192	15	vaccine	vaccine	NN
cord-302082-aaokc182	192	16	-	-	HYPH
cord-302082-aaokc182	192	17	mediated	mediate	VBN
cord-302082-aaokc182	192	18	immune	immune	JJ
cord-302082-aaokc182	192	19	escape	escape	NN
cord-302082-aaokc182	192	20	;	;	:
cord-302082-aaokc182	192	21	however	however	RB
cord-302082-aaokc182	192	22	,	,	,
cord-302082-aaokc182	192	23	new	new	JJ
cord-302082-aaokc182	192	24	vaccines	vaccine	NNS
cord-302082-aaokc182	192	25	against	against	IN
cord-302082-aaokc182	192	26	the	the	DT
cord-302082-aaokc182	192	27	pneumococcus	pneumococcus	NNP
cord-302082-aaokc182	192	28	have	have	VBP
cord-302082-aaokc182	192	29	been	be	VBN
cord-302082-aaokc182	192	30	licensed	license	VBN
cord-302082-aaokc182	192	31	,	,	,
cord-302082-aaokc182	192	32	including	include	VBG
cord-302082-aaokc182	192	33	additional	additional	JJ
cord-302082-aaokc182	192	34	capsular	capsular	JJ
cord-302082-aaokc182	192	35	types	type	NNS
cord-302082-aaokc182	192	36	,	,	,
cord-302082-aaokc182	192	37	to	to	TO
cord-302082-aaokc182	192	38	expand	expand	VB
cord-302082-aaokc182	192	39	the	the	DT
cord-302082-aaokc182	192	40	geographical	geographical	JJ
cord-302082-aaokc182	192	41	coverage	coverage	NN
cord-302082-aaokc182	192	42	of	of	IN
cord-302082-aaokc182	192	43	most	most	JJS
cord-302082-aaokc182	192	44	frequent	frequent	JJ
cord-302082-aaokc182	192	45	types	type	NNS
cord-302082-aaokc182	192	46	and	and	CC
cord-302082-aaokc182	192	47	,	,	,
cord-302082-aaokc182	192	48	in	in	IN
cord-302082-aaokc182	192	49	part	part	NN
cord-302082-aaokc182	192	50	,	,	,
cord-302082-aaokc182	192	51	to	to	TO
cord-302082-aaokc182	192	52	counter	counter	VB
cord-302082-aaokc182	192	53	the	the	DT
cord-302082-aaokc182	192	54	observed	observed	JJ
cord-302082-aaokc182	192	55	phenomenon	phenomenon	NN
cord-302082-aaokc182	192	56	of	of	IN
cord-302082-aaokc182	192	57	serotype	serotype	NN
cord-302082-aaokc182	192	58	replacement	replacement	NN
cord-302082-aaokc182	192	59	.	.	.
cord-302082-aaokc182	193	1	Annual	annual	JJ
cord-302082-aaokc182	193	2	seasonal	seasonal	JJ
cord-302082-aaokc182	193	3	influenza	influenza	NN
cord-302082-aaokc182	193	4	infections	infection	NNS
cord-302082-aaokc182	193	5	are	be	VBP
cord-302082-aaokc182	193	6	subject	subject	JJ
cord-302082-aaokc182	193	7	to	to	IN
cord-302082-aaokc182	193	8	natural	natural	JJ
cord-302082-aaokc182	193	9	antigenic	antigenic	JJ
cord-302082-aaokc182	193	10	drift	drift	NN
cord-302082-aaokc182	193	11	which	which	WDT
cord-302082-aaokc182	193	12	requires	require	VBZ
cord-302082-aaokc182	193	13	the	the	DT
cord-302082-aaokc182	193	14	reformulation	reformulation	NN
cord-302082-aaokc182	193	15	of	of	IN
cord-302082-aaokc182	193	16	the	the	DT
cord-302082-aaokc182	193	17	vaccine	vaccine	NN
cord-302082-aaokc182	193	18	when	when	WRB
cord-302082-aaokc182	193	19	drifts	drift	NNS
cord-302082-aaokc182	193	20	occur	occur	VBP
cord-302082-aaokc182	193	21	,	,	,
cord-302082-aaokc182	193	22	but	but	CC
cord-302082-aaokc182	193	23	there	there	EX
cord-302082-aaokc182	193	24	is	be	VBZ
cord-302082-aaokc182	193	25	no	no	DT
cord-302082-aaokc182	193	26	evidence	evidence	NN
cord-302082-aaokc182	193	27	that	that	IN
cord-302082-aaokc182	193	28	the	the	DT
cord-302082-aaokc182	193	29	deployment	deployment	NN
cord-302082-aaokc182	193	30	of	of	IN
cord-302082-aaokc182	193	31	the	the	DT
cord-302082-aaokc182	193	32	vaccine	vaccine	NN
cord-302082-aaokc182	193	33	accelerates	accelerate	VBZ
cord-302082-aaokc182	193	34	this	this	DT
cord-302082-aaokc182	193	35	drift	drift	NN
cord-302082-aaokc182	193	36	.	.	.
cord-302082-aaokc182	194	1	Antigenic	antigenic	JJ
cord-302082-aaokc182	194	2	shift	shift	NN
cord-302082-aaokc182	194	3	,	,	,
cord-302082-aaokc182	194	4	while	while	IN
cord-302082-aaokc182	194	5	not	not	RB
cord-302082-aaokc182	194	6	the	the	DT
cord-302082-aaokc182	194	7	result	result	NN
cord-302082-aaokc182	194	8	of	of	IN
cord-302082-aaokc182	194	9	selective	selective	JJ
cord-302082-aaokc182	194	10	pressure	pressure	NN
cord-302082-aaokc182	194	11	,	,	,
cord-302082-aaokc182	194	12	gives	give	VBZ
cord-302082-aaokc182	194	13	rise	rise	NN
cord-302082-aaokc182	194	14	to	to	IN
cord-302082-aaokc182	194	15	viral	viral	JJ
cord-302082-aaokc182	194	16	strains	strain	NNS
cord-302082-aaokc182	194	17	containing	contain	VBG
cord-302082-aaokc182	194	18	a	a	DT
cord-302082-aaokc182	194	19	mixture	mixture	NN
cord-302082-aaokc182	194	20	of	of	IN
cord-302082-aaokc182	194	21	the	the	DT
cord-302082-aaokc182	194	22	surface	surface	NN
cord-302082-aaokc182	194	23	antigens	antigen	NNS
cord-302082-aaokc182	194	24	from	from	IN
cord-302082-aaokc182	194	25	the	the	DT
cord-302082-aaokc182	194	26	parent	parent	NN
cord-302082-aaokc182	194	27	strains	strain	NNS
cord-302082-aaokc182	194	28	.	.	.
cord-302082-aaokc182	195	1	Pathogens	pathogen	NNS
cord-302082-aaokc182	195	2	that	that	WDT
cord-302082-aaokc182	195	3	can	can	MD
cord-302082-aaokc182	195	4	undergo	undergo	VB
cord-302082-aaokc182	195	5	antigenic	antigenic	JJ
cord-302082-aaokc182	195	6	shift	shift	NN
cord-302082-aaokc182	195	7	,	,	,
cord-302082-aaokc182	195	8	including	include	VBG
cord-302082-aaokc182	195	9	influenza	influenza	NN
cord-302082-aaokc182	195	10	viruses	virus	NNS
cord-302082-aaokc182	195	11	(	(	-LRB-
cord-302082-aaokc182	195	12	Figure	figure	NN
cord-302082-aaokc182	195	13	6	6	CD
cord-302082-aaokc182	195	14	.8	.8	CD
cord-302082-aaokc182	195	15	)	)	-RRB-
cord-302082-aaokc182	195	16	,	,	,
cord-302082-aaokc182	195	17	present	present	JJ
cord-302082-aaokc182	195	18	major	major	JJ
cord-302082-aaokc182	195	19	challenges	challenge	NNS
cord-302082-aaokc182	195	20	for	for	IN
cord-302082-aaokc182	195	21	vaccine	vaccine	NN
cord-302082-aaokc182	195	22	developers	developer	NNS
cord-302082-aaokc182	195	23	.	.	.
cord-302082-aaokc182	196	1	Chapter	chapter	NN
cord-302082-aaokc182	196	2	4	4	CD
cord-302082-aaokc182	196	3	e	e	NN
cord-302082-aaokc182	196	4	Vaccine	vaccine	NN
cord-302082-aaokc182	196	5	adjuvants	adjuvant	NNS
cord-302082-aaokc182	196	6	,	,	,
cord-302082-aaokc182	196	7	there	there	EX
cord-302082-aaokc182	196	8	has	have	VBZ
cord-302082-aaokc182	196	9	been	be	VBN
cord-302082-aaokc182	196	10	progress	progress	NN
cord-302082-aaokc182	196	11	in	in	IN
cord-302082-aaokc182	196	12	the	the	DT
cord-302082-aaokc182	196	13	Another	another	DT
cord-302082-aaokc182	196	14	approach	approach	NN
cord-302082-aaokc182	196	15	to	to	IN
cord-302082-aaokc182	196	16	the	the	DT
cord-302082-aaokc182	196	17	problem	problem	NN
cord-302082-aaokc182	196	18	of	of	IN
cord-302082-aaokc182	196	19	influenza	influenza	NN
cord-302082-aaokc182	196	20	genome	genome	NN
cord-302082-aaokc182	196	21	shifts	shift	NNS
cord-302082-aaokc182	196	22	has	have	VBZ
cord-302082-aaokc182	196	23	been	be	VBN
cord-302082-aaokc182	196	24	to	to	TO
cord-302082-aaokc182	196	25	target	target	VB
cord-302082-aaokc182	196	26	weakly	weakly	RB
cord-302082-aaokc182	196	27	immunogenic	immunogenic	JJ
cord-302082-aaokc182	196	28	conserved	conserved	JJ
cord-302082-aaokc182	196	29	antigens	antigen	NNS
cord-302082-aaokc182	196	30	such	such	JJ
cord-302082-aaokc182	196	31	as	as	IN
cord-302082-aaokc182	196	32	the	the	DT
cord-302082-aaokc182	196	33	influenza	influenza	NN
cord-302082-aaokc182	196	34	M2e	M2e	VBG
cord-302082-aaokc182	196	35	protein	protein	NN
cord-302082-aaokc182	196	36	.	.	.
cord-302082-aaokc182	197	1	One	one	CD
cord-302082-aaokc182	197	2	approach	approach	NN
cord-302082-aaokc182	197	3	to	to	IN
cord-302082-aaokc182	197	4	addressing	address	VBG
cord-302082-aaokc182	197	5	the	the	DT
cord-302082-aaokc182	197	6	weak	weak	JJ
cord-302082-aaokc182	197	7	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	197	8	of	of	IN
cord-302082-aaokc182	197	9	the	the	DT
cord-302082-aaokc182	197	10	antigen	antigen	NN
cord-302082-aaokc182	197	11	has	have	VBZ
cord-302082-aaokc182	197	12	been	be	VBN
cord-302082-aaokc182	197	13	to	to	TO
cord-302082-aaokc182	197	14	link	link	VB
cord-302082-aaokc182	197	15	it	-PRON-	PRP
cord-302082-aaokc182	197	16	to	to	IN
cord-302082-aaokc182	197	17	a	a	DT
cord-302082-aaokc182	197	18	potent	potent	JJ
cord-302082-aaokc182	197	19	Toll	toll	NN
cord-302082-aaokc182	197	20	-	-	HYPH
cord-302082-aaokc182	197	21	like	like	JJ
cord-302082-aaokc182	197	22	receptor	receptor	NN
cord-302082-aaokc182	197	23	adjuvant	adjuvant	NN
cord-302082-aaokc182	197	24	such	such	JJ
cord-302082-aaokc182	197	25	as	as	IN
cord-302082-aaokc182	197	26	flagellin	flagellin	NNP
cord-302082-aaokc182	197	27	,	,	,
cord-302082-aaokc182	197	28	an	an	DT
cord-302082-aaokc182	197	29	approach	approach	NN
cord-302082-aaokc182	197	30	developed	develop	VBN
cord-302082-aaokc182	197	31	by	by	IN
cord-302082-aaokc182	197	32	VaxInnate	VaxInnate	NNP
cord-302082-aaokc182	197	33	Inc.	Inc.	NNP
cord-302082-aaokc182	198	1	During	during	IN
cord-302082-aaokc182	198	2	primary	primary	JJ
cord-302082-aaokc182	198	3	infection	infection	NN
cord-302082-aaokc182	198	4	of	of	IN
cord-302082-aaokc182	198	5	a	a	DT
cord-302082-aaokc182	198	6	single	single	JJ
cord-302082-aaokc182	198	7	individual	individual	NN
cord-302082-aaokc182	198	8	with	with	IN
cord-302082-aaokc182	198	9	HIV	HIV	NNP
cord-302082-aaokc182	198	10	,	,	,
cord-302082-aaokc182	198	11	mutations	mutation	NNS
cord-302082-aaokc182	198	12	in	in	IN
cord-302082-aaokc182	198	13	surface	surface	NN
cord-302082-aaokc182	198	14	proteins	protein	NNS
cord-302082-aaokc182	198	15	of	of	IN
cord-302082-aaokc182	198	16	the	the	DT
cord-302082-aaokc182	198	17	virus	virus	NN
cord-302082-aaokc182	198	18	lead	lead	NN
cord-302082-aaokc182	198	19	to	to	IN
cord-302082-aaokc182	198	20	selection	selection	NN
cord-302082-aaokc182	198	21	of	of	IN
cord-302082-aaokc182	198	22	a	a	DT
cord-302082-aaokc182	198	23	'	'	``
cord-302082-aaokc182	198	24	cloud	cloud	NN
cord-302082-aaokc182	198	25	'	'	''
cord-302082-aaokc182	198	26	of	of	IN
cord-302082-aaokc182	198	27	antigenic	antigenic	JJ
cord-302082-aaokc182	198	28	variants	variant	NNS
cord-302082-aaokc182	198	29	that	that	WDT
cord-302082-aaokc182	198	30	can	can	MD
cord-302082-aaokc182	198	31	evade	evade	VB
cord-302082-aaokc182	198	32	the	the	DT
cord-302082-aaokc182	198	33	cell	cell	NN
cord-302082-aaokc182	198	34	-	-	HYPH
cord-302082-aaokc182	198	35	mediated	mediate	VBN
cord-302082-aaokc182	198	36	immune	immune	JJ
cord-302082-aaokc182	198	37	responses	response	NNS
cord-302082-aaokc182	198	38	complicating	complicate	VBG
cord-302082-aaokc182	198	39	the	the	DT
cord-302082-aaokc182	198	40	development	development	NN
cord-302082-aaokc182	198	41	of	of	IN
cord-302082-aaokc182	198	42	broadly	broadly	RB
cord-302082-aaokc182	198	43	effective	effective	JJ
cord-302082-aaokc182	198	44	vaccines	vaccine	NNS
cord-302082-aaokc182	198	45	.	.	.
cord-302082-aaokc182	199	1	This	this	DT
cord-302082-aaokc182	199	2	propensity	propensity	NN
cord-302082-aaokc182	199	3	for	for	IN
cord-302082-aaokc182	199	4	mutation	mutation	NN
cord-302082-aaokc182	199	5	has	have	VBZ
cord-302082-aaokc182	199	6	given	give	VBN
cord-302082-aaokc182	199	7	rise	rise	NN
cord-302082-aaokc182	199	8	to	to	IN
cord-302082-aaokc182	199	9	many	many	JJ
cord-302082-aaokc182	199	10	strains	strain	NNS
cord-302082-aaokc182	199	11	of	of	IN
cord-302082-aaokc182	199	12	HIV	HIV	NNP
cord-302082-aaokc182	199	13	(	(	-LRB-
cord-302082-aaokc182	199	14	Figure	figure	NN
cord-302082-aaokc182	199	15	6	6	CD
cord-302082-aaokc182	199	16	.9	.9	CD
cord-302082-aaokc182	199	17	)	)	-RRB-
cord-302082-aaokc182	199	18	.	.	.
cord-302082-aaokc182	200	1	Two	two	CD
cord-302082-aaokc182	200	2	types	type	NNS
cord-302082-aaokc182	200	3	of	of	IN
cord-302082-aaokc182	200	4	HIV	HIV	NNP
cord-302082-aaokc182	200	5	,	,	,
cord-302082-aaokc182	200	6	HIV-1	HIV-1	NNP
cord-302082-aaokc182	200	7	and	and	CC
cord-302082-aaokc182	200	8	HIV-2	HIV-2	NNP
cord-302082-aaokc182	200	9	,	,	,
cord-302082-aaokc182	200	10	have	have	VBP
cord-302082-aaokc182	200	11	been	be	VBN
cord-302082-aaokc182	200	12	identified	identify	VBN
cord-302082-aaokc182	200	13	,	,	,
cord-302082-aaokc182	200	14	with	with	IN
cord-302082-aaokc182	200	15	HIV-1	HIV-1	NNP
cord-302082-aaokc182	200	16	being	be	VBG
cord-302082-aaokc182	200	17	the	the	DT
cord-302082-aaokc182	200	18	most	most	RBS
cord-302082-aaokc182	200	19	common	common	JJ
cord-302082-aaokc182	200	20	.	.	.
cord-302082-aaokc182	201	1	On	on	IN
cord-302082-aaokc182	201	2	a	a	DT
cord-302082-aaokc182	201	3	global	global	JJ
cord-302082-aaokc182	201	4	scale	scale	NN
cord-302082-aaokc182	201	5	,	,	,
cord-302082-aaokc182	201	6	HIV-1	HIV-1	NNP
cord-302082-aaokc182	201	7	strains	strain	NNS
cord-302082-aaokc182	201	8	are	be	VBP
cord-302082-aaokc182	201	9	differentiated	differentiate	VBN
cord-302082-aaokc182	201	10	according	accord	VBG
cord-302082-aaokc182	201	11	to	to	IN
cord-302082-aaokc182	201	12	their	-PRON-	PRP$
cord-302082-aaokc182	201	13	respective	respective	JJ
cord-302082-aaokc182	201	14	group	group	NN
cord-302082-aaokc182	201	15	and	and	CC
cord-302082-aaokc182	201	16	subtypes	subtype	NNS
cord-302082-aaokc182	201	17	(	(	-LRB-
cord-302082-aaokc182	201	18	or	or	CC
cord-302082-aaokc182	201	19	'	'	``
cord-302082-aaokc182	201	20	clades	clade	NNS
cord-302082-aaokc182	201	21	'	'	''
cord-302082-aaokc182	201	22	)	)	-RRB-
cord-302082-aaokc182	202	1	within	within	IN
cord-302082-aaokc182	202	2	groups	group	NNS
cord-302082-aaokc182	202	3	.	.	.
cord-302082-aaokc182	203	1	The	the	DT
cord-302082-aaokc182	203	2	amino	amino	NN
cord-302082-aaokc182	203	3	acid	acid	NN
cord-302082-aaokc182	203	4	sequence	sequence	NN
cord-302082-aaokc182	203	5	of	of	IN
cord-302082-aaokc182	203	6	the	the	DT
cord-302082-aaokc182	203	7	viral	viral	JJ
cord-302082-aaokc182	203	8	envelope	envelope	NN
cord-302082-aaokc182	203	9	glycoprotein	glycoprotein	NN
cord-302082-aaokc182	203	10	gp120	gp120	NN
cord-302082-aaokc182	203	11	shows	show	VBZ
cord-302082-aaokc182	203	12	25e35	25e35	CD
cord-302082-aaokc182	203	13	%	%	NN
cord-302082-aaokc182	203	14	divergence	divergence	NN
cord-302082-aaokc182	203	15	between	between	IN
cord-302082-aaokc182	203	16	clades	clade	NNS
cord-302082-aaokc182	203	17	and	and	CC
cord-302082-aaokc182	203	18	up	up	IN
cord-302082-aaokc182	203	19	to	to	TO
cord-302082-aaokc182	203	20	20	20	CD
cord-302082-aaokc182	203	21	%	%	NN
cord-302082-aaokc182	203	22	divergence	divergence	NN
cord-302082-aaokc182	203	23	within	within	IN
cord-302082-aaokc182	203	24	any	any	DT
cord-302082-aaokc182	203	25	given	give	VBN
cord-302082-aaokc182	203	26	clade	clade	NN
cord-302082-aaokc182	203	27	,	,	,
cord-302082-aaokc182	203	28	which	which	WDT
cord-302082-aaokc182	203	29	constitutes	constitute	VBZ
cord-302082-aaokc182	203	30	a	a	DT
cord-302082-aaokc182	203	31	formidable	formidable	JJ
cord-302082-aaokc182	203	32	hurdle	hurdle	NN
cord-302082-aaokc182	203	33	to	to	IN
cord-302082-aaokc182	203	34	vaccine	vaccine	NN
cord-302082-aaokc182	203	35	development	development	NN
cord-302082-aaokc182	203	36	.	.	.
cord-302082-aaokc182	204	1	This	this	DT
cord-302082-aaokc182	204	2	is	be	VBZ
cord-302082-aaokc182	204	3	made	make	VBN
cord-302082-aaokc182	204	4	worse	bad	JJR
cord-302082-aaokc182	204	5	by	by	IN
cord-302082-aaokc182	204	6	recombination	recombination	NN
cord-302082-aaokc182	204	7	between	between	IN
cord-302082-aaokc182	204	8	clades	clade	NNS
cord-302082-aaokc182	204	9	of	of	IN
cord-302082-aaokc182	204	10	HIV-1	HIV-1	NNP
cord-302082-aaokc182	204	11	,	,	,
cord-302082-aaokc182	204	12	which	which	WDT
cord-302082-aaokc182	204	13	has	have	VBZ
cord-302082-aaokc182	204	14	produced	produce	VBN
cord-302082-aaokc182	204	15	circulating	circulate	VBG
cord-302082-aaokc182	204	16	recombinant	recombinant	JJ
cord-302082-aaokc182	204	17	forms	form	NNS
cord-302082-aaokc182	204	18	(	(	-LRB-
cord-302082-aaokc182	204	19	CRFs	CRFs	NNP
cord-302082-aaokc182	204	20	)	)	-RRB-
cord-302082-aaokc182	204	21	which	which	WDT
cord-302082-aaokc182	204	22	differ	differ	VBP
cord-302082-aaokc182	204	23	in	in	IN
cord-302082-aaokc182	204	24	antigenicity	antigenicity	NN
cord-302082-aaokc182	204	25	depending	depend	VBG
cord-302082-aaokc182	204	26	on	on	IN
cord-302082-aaokc182	204	27	the	the	DT
cord-302082-aaokc182	204	28	geographical	geographical	JJ
cord-302082-aaokc182	204	29	region	region	NN
cord-302082-aaokc182	204	30	.	.	.
cord-302082-aaokc182	204	31	 	 	_SP
cord-302082-aaokc182	205	1	Since	since	IN
cord-302082-aaokc182	205	2	the	the	DT
cord-302082-aaokc182	205	3	initiation	initiation	NN
cord-302082-aaokc182	205	4	of	of	IN
cord-302082-aaokc182	205	5	HIV	HIV	NNP
cord-302082-aaokc182	205	6	vaccine	vaccine	NN
cord-302082-aaokc182	205	7	programmes	programme	NNS
cord-302082-aaokc182	205	8	,	,	,
cord-302082-aaokc182	205	9	more	more	JJR
cord-302082-aaokc182	205	10	than	than	IN
cord-302082-aaokc182	205	11	30	30	CD
cord-302082-aaokc182	205	12	candidate	candidate	NN
cord-302082-aaokc182	205	13	vaccines	vaccine	NNS
cord-302082-aaokc182	205	14	have	have	VBP
cord-302082-aaokc182	205	15	been	be	VBN
cord-302082-aaokc182	205	16	tested	test	VBN
cord-302082-aaokc182	205	17	in	in	IN
cord-302082-aaokc182	205	18	over	over	IN
cord-302082-aaokc182	205	19	80	80	CD
cord-302082-aaokc182	205	20	Phase	phase	NN
cord-302082-aaokc182	205	21	I	I	NNP
cord-302082-aaokc182	205	22	/	/	SYM
cord-302082-aaokc182	205	23	II	II	NNP
cord-302082-aaokc182	205	24	clinical	clinical	JJ
cord-302082-aaokc182	205	25	trials	trial	NNS
cord-302082-aaokc182	205	26	involving	involve	VBG
cord-302082-aaokc182	205	27	more	more	JJR
cord-302082-aaokc182	205	28	than	than	IN
cord-302082-aaokc182	205	29	10,000	10,000	CD
cord-302082-aaokc182	205	30	healthy	healthy	JJ
cord-302082-aaokc182	205	31	human	human	JJ
cord-302082-aaokc182	205	32	volunteers	volunteer	NNS
cord-302082-aaokc182	205	33	.	.	.
cord-302082-aaokc182	206	1	Regrettably	regrettably	RB
cord-302082-aaokc182	206	2	,	,	,
cord-302082-aaokc182	206	3	all	all	DT
cord-302082-aaokc182	206	4	attempts	attempt	NNS
cord-302082-aaokc182	206	5	to	to	IN
cord-302082-aaokc182	206	6	date	date	NN
cord-302082-aaokc182	206	7	have	have	VBP
cord-302082-aaokc182	206	8	failed	fail	VBN
cord-302082-aaokc182	206	9	to	to	TO
cord-302082-aaokc182	206	10	yield	yield	VB
cord-302082-aaokc182	206	11	a	a	DT
cord-302082-aaokc182	206	12	licensed	licensed	JJ
cord-302082-aaokc182	206	13	HIV	HIV	NNP
cord-302082-aaokc182	206	14	vaccine	vaccine	NN
cord-302082-aaokc182	206	15	.	.	.
cord-302082-aaokc182	207	1	Questions	question	NNS
cord-302082-aaokc182	207	2	remain	remain	VBP
cord-302082-aaokc182	207	3	concerning	concern	VBG
cord-302082-aaokc182	207	4	the	the	DT
cord-302082-aaokc182	207	5	immune	immune	JJ
cord-302082-aaokc182	207	6	mechanisms	mechanism	NNS
cord-302082-aaokc182	207	7	behind	behind	IN
cord-302082-aaokc182	207	8	vaccines	vaccine	NNS
cord-302082-aaokc182	207	9	that	that	WDT
cord-302082-aaokc182	207	10	achieve	achieve	VBP
cord-302082-aaokc182	207	11	partial	partial	JJ
cord-302082-aaokc182	207	12	protection	protection	NN
cord-302082-aaokc182	207	13	.	.	.
cord-302082-aaokc182	208	1	Regardless	regardless	RB
cord-302082-aaokc182	208	2	of	of	IN
cord-302082-aaokc182	208	3	the	the	DT
cord-302082-aaokc182	208	4	unknowns	unknown	NNS
cord-302082-aaokc182	208	5	,	,	,
cord-302082-aaokc182	208	6	the	the	DT
cord-302082-aaokc182	208	7	ability	ability	NN
cord-302082-aaokc182	208	8	to	to	TO
cord-302082-aaokc182	208	9	prevent	prevent	VB
cord-302082-aaokc182	208	10	infection	infection	NN
cord-302082-aaokc182	208	11	in	in	IN
cord-302082-aaokc182	208	12	at	at	IN
cord-302082-aaokc182	208	13	least	least	JJS
cord-302082-aaokc182	208	14	some	some	DT
cord-302082-aaokc182	208	15	individuals	individual	NNS
cord-302082-aaokc182	208	16	still	still	RB
cord-302082-aaokc182	208	17	offers	offer	VBZ
cord-302082-aaokc182	208	18	real	real	JJ
cord-302082-aaokc182	208	19	hope	hope	NN
cord-302082-aaokc182	208	20	that	that	IN
cord-302082-aaokc182	208	21	a	a	DT
cord-302082-aaokc182	208	22	globally	globally	RB
cord-302082-aaokc182	208	23	effective	effective	JJ
cord-302082-aaokc182	208	24	HIV	HIV	NNP
cord-302082-aaokc182	208	25	vaccine	vaccine	NN
cord-302082-aaokc182	208	26	might	may	MD
cord-302082-aaokc182	208	27	be	be	VB
cord-302082-aaokc182	208	28	possible	possible	JJ
cord-302082-aaokc182	208	29	.	.	.
cord-302082-aaokc182	209	1	Current	current	JJ
cord-302082-aaokc182	209	2	research	research	NN
cord-302082-aaokc182	209	3	is	be	VBZ
cord-302082-aaokc182	209	4	comparing	compare	VBG
cord-302082-aaokc182	209	5	the	the	DT
cord-302082-aaokc182	209	6	immune	immune	JJ
cord-302082-aaokc182	209	7	responses	response	NNS
cord-302082-aaokc182	209	8	of	of	IN
cord-302082-aaokc182	209	9	subjects	subject	NNS
cord-302082-aaokc182	209	10	who	who	WP
cord-302082-aaokc182	209	11	are	be	VBP
cord-302082-aaokc182	209	12	naturally	naturally	RB
cord-302082-aaokc182	209	13	protected	protect	VBN
cord-302082-aaokc182	209	14	against	against	IN
cord-302082-aaokc182	209	15	HIV	HIV	NNP
cord-302082-aaokc182	209	16	with	with	IN
cord-302082-aaokc182	209	17	those	those	DT
cord-302082-aaokc182	209	18	who	who	WP
cord-302082-aaokc182	209	19	were	be	VBD
cord-302082-aaokc182	209	20	infected	infect	VBN
cord-302082-aaokc182	209	21	,	,	,
cord-302082-aaokc182	209	22	seeking	seek	VBG
cord-302082-aaokc182	209	23	to	to	TO
cord-302082-aaokc182	209	24	find	find	VB
cord-302082-aaokc182	209	25	the	the	DT
cord-302082-aaokc182	209	26	elusive	elusive	JJ
cord-302082-aaokc182	209	27	immunological	immunological	JJ
cord-302082-aaokc182	209	28	mechanisms	mechanism	NNS
cord-302082-aaokc182	209	29	of	of	IN
cord-302082-aaokc182	209	30	protection	protection	NN
cord-302082-aaokc182	209	31	to	to	TO
cord-302082-aaokc182	209	32	help	help	VB
cord-302082-aaokc182	209	33	guide	guide	VB
cord-302082-aaokc182	209	34	the	the	DT
cord-302082-aaokc182	209	35	design	design	NN
cord-302082-aaokc182	209	36	of	of	IN
cord-302082-aaokc182	209	37	future	future	JJ
cord-302082-aaokc182	209	38	T	t	NN
cord-302082-aaokc182	209	39	-	-	HYPH
cord-302082-aaokc182	209	40	cell	cell	NN
cord-302082-aaokc182	209	41	vaccines	vaccine	NNS
cord-302082-aaokc182	209	42	against	against	IN
cord-302082-aaokc182	209	43	the	the	DT
cord-302082-aaokc182	209	44	virus	virus	NN
cord-302082-aaokc182	209	45	.	.	.
cord-302082-aaokc182	210	1	Infections	infection	NNS
cord-302082-aaokc182	210	2	of	of	IN
cord-302082-aaokc182	210	3	group	group	NN
cord-302082-aaokc182	210	4	A	a	DT
cord-302082-aaokc182	210	5	streptococcal	streptococcal	JJ
cord-302082-aaokc182	210	6	serotypes	serotype	NNS
cord-302082-aaokc182	210	7	(	(	-LRB-
cord-302082-aaokc182	210	8	ie	ie	FW
cord-302082-aaokc182	210	9	Streptococcus	Streptococcus	NNP
cord-302082-aaokc182	210	10	pyogenes	pyogene	NNS
cord-302082-aaokc182	210	11	)	)	-RRB-
cord-302082-aaokc182	210	12	account	account	VBP
cord-302082-aaokc182	210	13	for	for	IN
cord-302082-aaokc182	210	14	approximately	approximately	RB
cord-302082-aaokc182	210	15	85	85	CD
cord-302082-aaokc182	210	16	%	%	NN
cord-302082-aaokc182	210	17	of	of	IN
cord-302082-aaokc182	210	18	cases	case	NNS
cord-302082-aaokc182	210	19	of	of	IN
cord-302082-aaokc182	210	20	 	 	_SP
cord-302082-aaokc182	210	21	uncomplicated	uncomplicated	JJ
cord-302082-aaokc182	210	22	bacterial	bacterial	JJ
cord-302082-aaokc182	210	23	pharyngitis	pharyngitis	NN
cord-302082-aaokc182	210	24	and	and	CC
cord-302082-aaokc182	210	25	streptococcal	streptococcal	JJ
cord-302082-aaokc182	210	26	invasive	invasive	JJ
cord-302082-aaokc182	210	27	infections	infection	NNS
cord-302082-aaokc182	210	28	in	in	IN
cord-302082-aaokc182	210	29	North	North	NNP
cord-302082-aaokc182	210	30	America	America	NNP
cord-302082-aaokc182	210	31	.	.	.
cord-302082-aaokc182	211	1	The	the	DT
cord-302082-aaokc182	211	2	M	M	NNP
cord-302082-aaokc182	211	3	protein	protein	NN
cord-302082-aaokc182	211	4	of	of	IN
cord-302082-aaokc182	211	5	group	group	NN
cord-302082-aaokc182	211	6	A	a	DT
cord-302082-aaokc182	211	7	streptococci	streptococcus	NNS
cord-302082-aaokc182	211	8	is	be	VBZ
cord-302082-aaokc182	211	9	a	a	DT
cord-302082-aaokc182	211	10	major	major	JJ
cord-302082-aaokc182	211	11	virulence	virulence	NN
cord-302082-aaokc182	211	12	determinant	determinant	NN
cord-302082-aaokc182	211	13	of	of	IN
cord-302082-aaokc182	211	14	these	these	DT
cord-302082-aaokc182	211	15	organisms	organism	NNS
cord-302082-aaokc182	211	16	and	and	CC
cord-302082-aaokc182	211	17	also	also	RB
cord-302082-aaokc182	211	18	functions	function	VBZ
cord-302082-aaokc182	211	19	as	as	IN
cord-302082-aaokc182	211	20	a	a	DT
cord-302082-aaokc182	211	21	major	major	JJ
cord-302082-aaokc182	211	22	target	target	NN
cord-302082-aaokc182	211	23	for	for	IN
cord-302082-aaokc182	211	24	protective	protective	JJ
cord-302082-aaokc182	211	25	antibodies	antibody	NNS
cord-302082-aaokc182	211	26	.	.	.
cord-302082-aaokc182	212	1	One	one	CD
cord-302082-aaokc182	212	2	of	of	IN
cord-302082-aaokc182	212	3	several	several	JJ
cord-302082-aaokc182	212	4	strategies	strategy	NNS
cord-302082-aaokc182	212	5	for	for	IN
cord-302082-aaokc182	212	6	vaccine	vaccine	NN
cord-302082-aaokc182	212	7	prevention	prevention	NN
cord-302082-aaokc182	212	8	of	of	IN
cord-302082-aaokc182	212	9	these	these	DT
cord-302082-aaokc182	212	10	infections	infection	NNS
cord-302082-aaokc182	212	11	is	be	VBZ
cord-302082-aaokc182	212	12	based	base	VBN
cord-302082-aaokc182	212	13	on	on	IN
cord-302082-aaokc182	212	14	type	type	NN
cord-302082-aaokc182	212	15	-	-	HYPH
cord-302082-aaokc182	212	16	specific	specific	JJ
cord-302082-aaokc182	212	17	M	M	NNP
cord-302082-aaokc182	212	18	protein	protein	NN
cord-302082-aaokc182	212	19	epitopes	epitope	NNS
cord-302082-aaokc182	212	20	.	.	.
cord-302082-aaokc182	213	1	However	however	RB
cord-302082-aaokc182	213	2	,	,	,
cord-302082-aaokc182	213	3	group	group	NN
cord-302082-aaokc182	213	4	A	a	DT
cord-302082-aaokc182	213	5	streptococcal	streptococcal	JJ
cord-302082-aaokc182	213	6	vaccine	vaccine	NN
cord-302082-aaokc182	213	7	development	development	NN
cord-302082-aaokc182	213	8	faces	face	VBZ
cord-302082-aaokc182	213	9	many	many	JJ
cord-302082-aaokc182	213	10	obstacles	obstacle	NNS
cord-302082-aaokc182	213	11	:	:	:
cord-302082-aaokc182	213	12	i	i	LS
cord-302082-aaokc182	213	13	)	)	-RRB-
cord-302082-aaokc182	213	14	the	the	DT
cord-302082-aaokc182	213	15	widespread	widespread	JJ
cord-302082-aaokc182	213	16	diversity	diversity	NN
cord-302082-aaokc182	213	17	of	of	IN
cord-302082-aaokc182	213	18	circulating	circulate	VBG
cord-302082-aaokc182	213	19	M	M	NNP
cord-302082-aaokc182	213	20	protein	protein	NN
cord-302082-aaokc182	213	21	types	type	NNS
cord-302082-aaokc182	213	22	;	;	:
cord-302082-aaokc182	213	23	ii	ii	LS
cord-302082-aaokc182	213	24	)	)	-RRB-
cord-302082-aaokc182	213	25	immunological	immunological	JJ
cord-302082-aaokc182	213	26	cross	cross	NN
cord-302082-aaokc182	213	27	-	-	NN
cord-302082-aaokc182	213	28	reactivity	reactivity	NN
cord-302082-aaokc182	213	29	between	between	IN
cord-302082-aaokc182	213	30	epitopes	epitope	NNS
cord-302082-aaokc182	213	31	in	in	IN
cord-302082-aaokc182	213	32	the	the	DT
cord-302082-aaokc182	213	33	M	M	NNP
cord-302082-aaokc182	213	34	protein	protein	NN
cord-302082-aaokc182	213	35	and	and	CC
cord-302082-aaokc182	213	36	several	several	JJ
cord-302082-aaokc182	213	37	human	human	JJ
cord-302082-aaokc182	213	38	tissues	tissue	NNS
cord-302082-aaokc182	213	39	introducing	introduce	VBG
cord-302082-aaokc182	213	40	an	an	DT
cord-302082-aaokc182	213	41	autoimmune	autoimmune	JJ
cord-302082-aaokc182	213	42	risk	risk	NN
cord-302082-aaokc182	213	43	;	;	:
cord-302082-aaokc182	213	44	and	and	CC
cord-302082-aaokc182	213	45	iii	iii	LS
cord-302082-aaokc182	213	46	)	)	-RRB-
cord-302082-aaokc182	213	47	animal	animal	NN
cord-302082-aaokc182	213	48	models	model	NNS
cord-302082-aaokc182	213	49	are	be	VBP
cord-302082-aaokc182	213	50	of	of	IN
cord-302082-aaokc182	213	51	limited	limited	JJ
cord-302082-aaokc182	213	52	value	value	NN
cord-302082-aaokc182	213	53	because	because	IN
cord-302082-aaokc182	213	54	humans	human	NNS
cord-302082-aaokc182	213	55	are	be	VBP
cord-302082-aaokc182	213	56	the	the	DT
cord-302082-aaokc182	213	57	only	only	JJ
cord-302082-aaokc182	213	58	hosts	host	NNS
cord-302082-aaokc182	213	59	for	for	IN
cord-302082-aaokc182	213	60	group	group	NN
cord-302082-aaokc182	213	61	A	a	DT
cord-302082-aaokc182	213	62	streptococci	streptococcus	NNS
cord-302082-aaokc182	213	63	.	.	.
cord-302082-aaokc182	214	1	In	in	IN
cord-302082-aaokc182	214	2	an	an	DT
cord-302082-aaokc182	214	3	attempt	attempt	NN
cord-302082-aaokc182	214	4	to	to	TO
cord-302082-aaokc182	214	5	partially	partially	RB
cord-302082-aaokc182	214	6	overcome	overcome	VB
cord-302082-aaokc182	214	7	some	some	DT
cord-302082-aaokc182	214	8	of	of	IN
cord-302082-aaokc182	214	9	these	these	DT
cord-302082-aaokc182	214	10	obstacles	obstacle	NNS
cord-302082-aaokc182	214	11	,	,	,
cord-302082-aaokc182	214	12	a	a	DT
cord-302082-aaokc182	214	13	design	design	NN
cord-302082-aaokc182	214	14	strategy	strategy	NN
cord-302082-aaokc182	214	15	akin	akin	JJ
cord-302082-aaokc182	214	16	to	to	IN
cord-302082-aaokc182	214	17	that	that	DT
cord-302082-aaokc182	214	18	of	of	IN
cord-302082-aaokc182	214	19	the	the	DT
cord-302082-aaokc182	214	20	pneumococcal	pneumococcal	JJ
cord-302082-aaokc182	214	21	polysaccharide	polysaccharide	NN
cord-302082-aaokc182	214	22	vaccines	vaccine	NNS
cord-302082-aaokc182	214	23	has	have	VBZ
cord-302082-aaokc182	214	24	been	be	VBN
cord-302082-aaokc182	214	25	employed	employ	VBN
cord-302082-aaokc182	214	26	to	to	TO
cord-302082-aaokc182	214	27	generate	generate	VB
cord-302082-aaokc182	214	28	a	a	DT
cord-302082-aaokc182	214	29	group	group	NN
cord-302082-aaokc182	214	30	A	a	DT
cord-302082-aaokc182	214	31	streptococci	streptococcus	NNS
cord-302082-aaokc182	214	32	multivalent	multivalent	JJ
cord-302082-aaokc182	214	33	M	M	NNP
cord-302082-aaokc182	214	34	protein	protein	NN
cord-302082-aaokc182	214	35	-	-	HYPH
cord-302082-aaokc182	214	36	based	base	VBN
cord-302082-aaokc182	214	37	vaccine	vaccine	NN
cord-302082-aaokc182	214	38	containing	contain	VBG
cord-302082-aaokc182	214	39	type	type	NN
cord-302082-aaokc182	214	40	-	-	HYPH
cord-302082-aaokc182	214	41	specific	specific	JJ
cord-302082-aaokc182	214	42	determinants	determinant	NNS
cord-302082-aaokc182	214	43	from	from	IN
cord-302082-aaokc182	214	44	26	26	CD
cord-302082-aaokc182	214	45	different	different	JJ
cord-302082-aaokc182	214	46	M	M	NNP
cord-302082-aaokc182	214	47	serotypes	serotype	NNS
cord-302082-aaokc182	214	48	.	.	.
cord-302082-aaokc182	215	1	This	this	DT
cord-302082-aaokc182	215	2	multivalent	multivalent	JJ
cord-302082-aaokc182	215	3	vaccine	vaccine	NN
cord-302082-aaokc182	215	4	is	be	VBZ
cord-302082-aaokc182	215	5	currently	currently	RB
cord-302082-aaokc182	215	6	in	in	IN
cord-302082-aaokc182	215	7	clinical	clinical	JJ
cord-302082-aaokc182	215	8	development	development	NN
cord-302082-aaokc182	215	9	.	.	.
cord-302082-aaokc182	216	1	The	the	DT
cord-302082-aaokc182	216	2	'	'	``
cord-302082-aaokc182	216	3	prime	prime	JJ
cord-302082-aaokc182	216	4	-	-	HYPH
cord-302082-aaokc182	216	5	boost	boost	NN
cord-302082-aaokc182	216	6	'	'	''
cord-302082-aaokc182	216	7	approach	approach	NN
cord-302082-aaokc182	216	8	The	the	DT
cord-302082-aaokc182	216	9	term	term	NN
cord-302082-aaokc182	216	10	'	'	``
cord-302082-aaokc182	216	11	prime	prime	JJ
cord-302082-aaokc182	216	12	boost	boost	NN
cord-302082-aaokc182	216	13	'	'	''
cord-302082-aaokc182	216	14	(	(	-LRB-
cord-302082-aaokc182	216	15	or	or	CC
cord-302082-aaokc182	216	16	heterologous	heterologous	JJ
cord-302082-aaokc182	216	17	boosting	boosting	NN
cord-302082-aaokc182	216	18	)	)	-RRB-
cord-302082-aaokc182	216	19	describes	describe	VBZ
cord-302082-aaokc182	216	20	an	an	DT
cord-302082-aaokc182	216	21	approach	approach	NN
cord-302082-aaokc182	216	22	to	to	IN
cord-302082-aaokc182	216	23	vaccination	vaccination	NN
cord-302082-aaokc182	216	24	where	where	WRB
cord-302082-aaokc182	216	25	one	one	CD
cord-302082-aaokc182	216	26	type	type	NN
cord-302082-aaokc182	216	27	of	of	IN
cord-302082-aaokc182	216	28	vaccine	vaccine	NN
cord-302082-aaokc182	216	29	,	,	,
cord-302082-aaokc182	216	30	such	such	JJ
cord-302082-aaokc182	216	31	as	as	IN
cord-302082-aaokc182	216	32	a	a	DT
cord-302082-aaokc182	216	33	live	live	JJ
cord-302082-aaokc182	216	34	-	-	HYPH
cord-302082-aaokc182	216	35	vector	vector	NN
cord-302082-aaokc182	216	36	vaccine	vaccine	NN
cord-302082-aaokc182	216	37	,	,	,
cord-302082-aaokc182	216	38	is	be	VBZ
cord-302082-aaokc182	216	39	administered	administer	VBN
cord-302082-aaokc182	216	40	followed	follow	VBN
cord-302082-aaokc182	216	41	by	by	IN
cord-302082-aaokc182	216	42	a	a	DT
cord-302082-aaokc182	216	43	second	second	JJ
cord-302082-aaokc182	216	44	type	type	NN
cord-302082-aaokc182	216	45	of	of	IN
cord-302082-aaokc182	216	46	vaccine	vaccine	NN
cord-302082-aaokc182	216	47	,	,	,
cord-302082-aaokc182	216	48	such	such	JJ
cord-302082-aaokc182	216	49	as	as	IN
cord-302082-aaokc182	216	50	a	a	DT
cord-302082-aaokc182	216	51	recombinant	recombinant	JJ
cord-302082-aaokc182	216	52	subunit	subunit	NN
cord-302082-aaokc182	216	53	vaccine	vaccine	NN
cord-302082-aaokc182	216	54	.	.	.
cord-302082-aaokc182	217	1	This	this	DT
cord-302082-aaokc182	217	2	is	be	VBZ
cord-302082-aaokc182	217	3	in	in	IN
cord-302082-aaokc182	217	4	contrast	contrast	NN
cord-302082-aaokc182	217	5	with	with	IN
cord-302082-aaokc182	217	6	the	the	DT
cord-302082-aaokc182	217	7	traditional	traditional	JJ
cord-302082-aaokc182	217	8	method	method	NN
cord-302082-aaokc182	217	9	of	of	IN
cord-302082-aaokc182	217	10	homologous	homologous	JJ
cord-302082-aaokc182	217	11	boosting	boosting	NN
cord-302082-aaokc182	217	12	in	in	IN
cord-302082-aaokc182	217	13	which	which	WDT
cord-302082-aaokc182	217	14	two	two	CD
cord-302082-aaokc182	217	15	or	or	CC
cord-302082-aaokc182	217	16	more	more	JJR
cord-302082-aaokc182	217	17	doses	dose	NNS
cord-302082-aaokc182	217	18	of	of	IN
cord-302082-aaokc182	217	19	the	the	DT
cord-302082-aaokc182	217	20	same	same	JJ
cord-302082-aaokc182	217	21	vaccine	vaccine	NN
cord-302082-aaokc182	217	22	are	be	VBP
cord-302082-aaokc182	217	23	given	give	VBN
cord-302082-aaokc182	217	24	successively	successively	RB
cord-302082-aaokc182	217	25	.	.	.
cord-302082-aaokc182	218	1	The	the	DT
cord-302082-aaokc182	218	2	intent	intent	NN
cord-302082-aaokc182	218	3	of	of	IN
cord-302082-aaokc182	218	4	prime	prime	JJ
cord-302082-aaokc182	218	5	-	-	HYPH
cord-302082-aaokc182	218	6	boost	boost	NN
cord-302082-aaokc182	218	7	vaccination	vaccination	NN
cord-302082-aaokc182	218	8	is	be	VBZ
cord-302082-aaokc182	218	9	to	to	TO
cord-302082-aaokc182	218	10	induce	induce	VB
cord-302082-aaokc182	218	11	different	different	JJ
cord-302082-aaokc182	218	12	types	type	NNS
cord-302082-aaokc182	218	13	of	of	IN
cord-302082-aaokc182	218	14	immune	immune	JJ
cord-302082-aaokc182	218	15	responses	response	NNS
cord-302082-aaokc182	218	16	and	and	CC
cord-302082-aaokc182	218	17	enhance	enhance	VB
cord-302082-aaokc182	218	18	the	the	DT
cord-302082-aaokc182	218	19	overall	overall	JJ
cord-302082-aaokc182	218	20	immune	immune	JJ
cord-302082-aaokc182	218	21	response	response	NN
cord-302082-aaokc182	218	22	,	,	,
cord-302082-aaokc182	218	23	a	a	DT
cord-302082-aaokc182	218	24	result	result	NN
cord-302082-aaokc182	218	25	that	that	WDT
cord-302082-aaokc182	218	26	may	may	MD
cord-302082-aaokc182	218	27	not	not	RB
cord-302082-aaokc182	218	28	occur	occur	VB
cord-302082-aaokc182	218	29	if	if	IN
cord-302082-aaokc182	218	30	only	only	RB
cord-302082-aaokc182	218	31	one	one	CD
cord-302082-aaokc182	218	32	type	type	NN
cord-302082-aaokc182	218	33	of	of	IN
cord-302082-aaokc182	218	34	vaccine	vaccine	NN
cord-302082-aaokc182	218	35	were	be	VBD
cord-302082-aaokc182	218	36	to	to	TO
cord-302082-aaokc182	218	37	be	be	VB
cord-302082-aaokc182	218	38	given	give	VBN
cord-302082-aaokc182	218	39	for	for	IN
cord-302082-aaokc182	218	40	all	all	DT
cord-302082-aaokc182	218	41	doses	dose	NNS
cord-302082-aaokc182	218	42	.	.	.
cord-302082-aaokc182	219	1	This	this	DT
cord-302082-aaokc182	219	2	approach	approach	NN
cord-302082-aaokc182	219	3	has	have	VBZ
cord-302082-aaokc182	219	4	been	be	VBN
cord-302082-aaokc182	219	5	employed	employ	VBN
cord-302082-aaokc182	219	6	in	in	IN
cord-302082-aaokc182	219	7	trials	trial	NNS
cord-302082-aaokc182	219	8	with	with	IN
cord-302082-aaokc182	219	9	,	,	,
cord-302082-aaokc182	219	10	for	for	IN
cord-302082-aaokc182	219	11	example	example	NN
cord-302082-aaokc182	219	12	,	,	,
cord-302082-aaokc182	219	13	TB	TB	NNP
cord-302082-aaokc182	219	14	,	,	,
cord-302082-aaokc182	219	15	CMV	CMV	NNP
cord-302082-aaokc182	219	16	,	,	,
cord-302082-aaokc182	219	17	malaria	malaria	NN
cord-302082-aaokc182	219	18	and	and	CC
cord-302082-aaokc182	219	19	HIV	HIV	NNP
cord-302082-aaokc182	219	20	candidate	candidate	NN
cord-302082-aaokc182	219	21	vaccines	vaccine	NNS
cord-302082-aaokc182	219	22	.	.	.
cord-302082-aaokc182	220	1	For	for	IN
cord-302082-aaokc182	220	2	example	example	NN
cord-302082-aaokc182	220	3	,	,	,
cord-302082-aaokc182	220	4	in	in	IN
cord-302082-aaokc182	220	5	studies	study	NNS
cord-302082-aaokc182	220	6	on	on	IN
cord-302082-aaokc182	220	7	new	new	JJ
cord-302082-aaokc182	220	8	TB	TB	NNP
cord-302082-aaokc182	220	9	vaccines	vaccine	NNS
cord-302082-aaokc182	220	10	,	,	,
cord-302082-aaokc182	220	11	subjects	subject	NNS
cord-302082-aaokc182	220	12	already	already	RB
cord-302082-aaokc182	220	13	primed	prime	VBN
cord-302082-aaokc182	220	14	with	with	IN
cord-302082-aaokc182	220	15	the	the	DT
cord-302082-aaokc182	220	16	live	live	JJ
cord-302082-aaokc182	220	17	,	,	,
cord-302082-aaokc182	220	18	attenuated	attenuated	JJ
cord-302082-aaokc182	220	19	BCG	BCG	NNP
cord-302082-aaokc182	220	20	vaccine	vaccine	NN
cord-302082-aaokc182	220	21	have	have	VBP
cord-302082-aaokc182	220	22	been	be	VBN
cord-302082-aaokc182	220	23	boosted	boost	VBN
cord-302082-aaokc182	220	24	with	with	IN
cord-302082-aaokc182	220	25	a	a	DT
cord-302082-aaokc182	220	26	subunit	subunit	NN
cord-302082-aaokc182	220	27	adjuvanted	adjuvante	VBN
cord-302082-aaokc182	220	28	vaccine	vaccine	NN
cord-302082-aaokc182	220	29	(	(	-LRB-
cord-302082-aaokc182	220	30	see	see	VB
cord-302082-aaokc182	220	31	Tuberculosis	Tuberculosis	NNP
cord-302082-aaokc182	220	32	)	)	-RRB-
cord-302082-aaokc182	220	33	.	.	.
cord-302082-aaokc182	220	34	 	 	_SP
cord-302082-aaokc182	221	1	Respiratory	respiratory	JJ
cord-302082-aaokc182	221	2	syncytial	syncytial	JJ
cord-302082-aaokc182	221	3	virus	virus	NN
cord-302082-aaokc182	221	4	is	be	VBZ
cord-302082-aaokc182	221	5	a	a	DT
cord-302082-aaokc182	221	6	common	common	JJ
cord-302082-aaokc182	221	7	cause	cause	NN
cord-302082-aaokc182	221	8	of	of	IN
cord-302082-aaokc182	221	9	bronchiolitis	bronchiolitis	NN
cord-302082-aaokc182	221	10	and	and	CC
cord-302082-aaokc182	221	11	pneumonia	pneumonia	NN
cord-302082-aaokc182	221	12	in	in	IN
cord-302082-aaokc182	221	13	infants	infant	NNS
cord-302082-aaokc182	221	14	,	,	,
cord-302082-aaokc182	221	15	and	and	CC
cord-302082-aaokc182	221	16	exacerbations	exacerbation	NNS
cord-302082-aaokc182	221	17	of	of	IN
cord-302082-aaokc182	221	18	chronic	chronic	JJ
cord-302082-aaokc182	221	19	obstructive	obstructive	JJ
cord-302082-aaokc182	221	20	pulmonary	pulmonary	JJ
cord-302082-aaokc182	221	21	disease	disease	NN
cord-302082-aaokc182	221	22	in	in	IN
cord-302082-aaokc182	221	23	the	the	DT
cord-302082-aaokc182	221	24	elderly	elderly	JJ
cord-302082-aaokc182	221	25	.	.	.
cord-302082-aaokc182	222	1	The	the	DT
cord-302082-aaokc182	222	2	development	development	NN
cord-302082-aaokc182	222	3	of	of	IN
cord-302082-aaokc182	222	4	an	an	DT
cord-302082-aaokc182	222	5	effective	effective	JJ
cord-302082-aaokc182	222	6	vaccine	vaccine	NN
cord-302082-aaokc182	222	7	has	have	VBZ
cord-302082-aaokc182	222	8	been	be	VBN
cord-302082-aaokc182	222	9	challenging	challenging	JJ
cord-302082-aaokc182	222	10	;	;	:
cord-302082-aaokc182	222	11	natural	natural	JJ
cord-302082-aaokc182	222	12	immunity	immunity	NN
cord-302082-aaokc182	222	13	to	to	IN
cord-302082-aaokc182	222	14	RSV	RSV	NNP
cord-302082-aaokc182	222	15	infection	infection	NN
cord-302082-aaokc182	222	16	is	be	VBZ
cord-302082-aaokc182	222	17	incomplete	incomplete	JJ
cord-302082-aaokc182	222	18	and	and	CC
cord-302082-aaokc182	222	19	re	re	NNS
cord-302082-aaokc182	222	20	-	-	NNS
cord-302082-aaokc182	222	21	infections	infection	NNS
cord-302082-aaokc182	222	22	occur	occur	VBP
cord-302082-aaokc182	222	23	in	in	IN
cord-302082-aaokc182	222	24	all	all	DT
cord-302082-aaokc182	222	25	age	age	NN
cord-302082-aaokc182	222	26	groups	group	NNS
cord-302082-aaokc182	222	27	.	.	.
cord-302082-aaokc182	223	1	Moreover	moreover	RB
cord-302082-aaokc182	223	2	,	,	,
cord-302082-aaokc182	223	3	the	the	DT
cord-302082-aaokc182	223	4	primary	primary	JJ
cord-302082-aaokc182	223	5	target	target	NN
cord-302082-aaokc182	223	6	population	population	NN
cord-302082-aaokc182	223	7	for	for	IN
cord-302082-aaokc182	223	8	vaccination	vaccination	NN
cord-302082-aaokc182	223	9	is	be	VBZ
cord-302082-aaokc182	223	10	newborns	newborn	NNS
cord-302082-aaokc182	223	11	and	and	CC
cord-302082-aaokc182	223	12	young	young	JJ
cord-302082-aaokc182	223	13	infants	infant	NNS
cord-302082-aaokc182	223	14	,	,	,
cord-302082-aaokc182	223	15	and	and	CC
cord-302082-aaokc182	223	16	they	-PRON-	PRP
cord-302082-aaokc182	223	17	are	be	VBP
cord-302082-aaokc182	223	18	a	a	DT
cord-302082-aaokc182	223	19	challenging	challenging	JJ
cord-302082-aaokc182	223	20	population	population	NN
cord-302082-aaokc182	223	21	as	as	IN
cord-302082-aaokc182	223	22	they	-PRON-	PRP
cord-302082-aaokc182	223	23	have	have	VBP
cord-302082-aaokc182	223	24	relatively	relatively	RB
cord-302082-aaokc182	223	25	immature	immature	JJ
cord-302082-aaokc182	223	26	immune	immune	JJ
cord-302082-aaokc182	223	27	systems	system	NNS
cord-302082-aaokc182	223	28	and	and	CC
cord-302082-aaokc182	223	29	the	the	DT
cord-302082-aaokc182	223	30	presence	presence	NN
cord-302082-aaokc182	223	31	of	of	IN
cord-302082-aaokc182	223	32	maternal	maternal	JJ
cord-302082-aaokc182	223	33	antibodies	antibody	NNS
cord-302082-aaokc182	223	34	may	may	MD
cord-302082-aaokc182	223	35	interfere	interfere	VB
cord-302082-aaokc182	223	36	with	with	IN
cord-302082-aaokc182	223	37	vaccination	vaccination	NN
cord-302082-aaokc182	223	38	of	of	IN
cord-302082-aaokc182	223	39	the	the	DT
cord-302082-aaokc182	223	40	young	young	JJ
cord-302082-aaokc182	223	41	infant	infant	NN
cord-302082-aaokc182	223	42	(	(	-LRB-
cord-302082-aaokc182	223	43	see	see	VB
cord-302082-aaokc182	223	44	Chapter	chapter	NN
cord-302082-aaokc182	223	45	2	2	CD
cord-302082-aaokc182	223	46	e	e	NN
cord-302082-aaokc182	223	47	Vaccine	vaccine	NN
cord-302082-aaokc182	223	48	immunology	immunology	NN
cord-302082-aaokc182	223	49	)	)	-RRB-
cord-302082-aaokc182	223	50	.	.	.
cord-302082-aaokc182	224	1	The	the	DT
cord-302082-aaokc182	224	2	initial	initial	JJ
cord-302082-aaokc182	224	3	efforts	effort	NNS
cord-302082-aaokc182	224	4	to	to	TO
cord-302082-aaokc182	224	5	develop	develop	VB
cord-302082-aaokc182	224	6	a	a	DT
cord-302082-aaokc182	224	7	formalin	formalin	NN
cord-302082-aaokc182	224	8	-	-	HYPH
cord-302082-aaokc182	224	9	inactivated	inactivate	VBN
cord-302082-aaokc182	224	10	cell	cell	NN
cord-302082-aaokc182	224	11	culture	culture	NN
cord-302082-aaokc182	224	12	-	-	HYPH
cord-302082-aaokc182	224	13	derived	derive	VBN
cord-302082-aaokc182	224	14	RSV	RSV	NNP
cord-302082-aaokc182	224	15	vaccine	vaccine	NN
cord-302082-aaokc182	224	16	resulted	result	VBD
cord-302082-aaokc182	224	17	in	in	IN
cord-302082-aaokc182	224	18	an	an	DT
cord-302082-aaokc182	224	19	unanticipated	unanticipated	JJ
cord-302082-aaokc182	224	20	enhancement	enhancement	NN
cord-302082-aaokc182	224	21	of	of	IN
cord-302082-aaokc182	224	22	natural	natural	JJ
cord-302082-aaokc182	224	23	RSV	RSV	NNP
cord-302082-aaokc182	224	24	disease	disease	NN
cord-302082-aaokc182	224	25	in	in	IN
cord-302082-aaokc182	224	26	some	some	DT
cord-302082-aaokc182	224	27	of	of	IN
cord-302082-aaokc182	224	28	the	the	DT
cord-302082-aaokc182	224	29	RSV	RSV	NNP
cord-302082-aaokc182	224	30	-	-	HYPH
cord-302082-aaokc182	224	31	naïve	naïve	JJ
cord-302082-aaokc182	224	32	infants	infant	NNS
cord-302082-aaokc182	224	33	who	who	WP
cord-302082-aaokc182	224	34	received	receive	VBD
cord-302082-aaokc182	224	35	the	the	DT
cord-302082-aaokc182	224	36	vaccine	vaccine	NN
cord-302082-aaokc182	224	37	in	in	IN
cord-302082-aaokc182	224	38	a	a	DT
cord-302082-aaokc182	224	39	clinical	clinical	JJ
cord-302082-aaokc182	224	40	trial	trial	NN
cord-302082-aaokc182	224	41	and	and	CC
cord-302082-aaokc182	224	42	subsequently	subsequently	RB
cord-302082-aaokc182	224	43	were	be	VBD
cord-302082-aaokc182	224	44	exposed	expose	VBN
cord-302082-aaokc182	224	45	to	to	IN
cord-302082-aaokc182	224	46	RSV	RSV	NNP
cord-302082-aaokc182	224	47	.	.	.
cord-302082-aaokc182	225	1	The	the	DT
cord-302082-aaokc182	225	2	exacerbated	exacerbated	JJ
cord-302082-aaokc182	225	3	disease	disease	NN
cord-302082-aaokc182	225	4	is	be	VBZ
cord-302082-aaokc182	225	5	thought	think	VBN
cord-302082-aaokc182	225	6	to	to	TO
cord-302082-aaokc182	225	7	be	be	VB
cord-302082-aaokc182	225	8	due	due	JJ
cord-302082-aaokc182	225	9	to	to	IN
cord-302082-aaokc182	225	10	an	an	DT
cord-302082-aaokc182	225	11	exaggerated	exaggerated	JJ
cord-302082-aaokc182	225	12	T	t	NN
cord-302082-aaokc182	225	13	helper	helper	NN
cord-302082-aaokc182	225	14	type	type	NN
cord-302082-aaokc182	225	15	2	2	CD
cord-302082-aaokc182	225	16	cell	cell	NN
cord-302082-aaokc182	225	17	immune	immune	JJ
cord-302082-aaokc182	225	18	response	response	NN
cord-302082-aaokc182	225	19	(	(	-LRB-
cord-302082-aaokc182	225	20	see	see	VB
cord-302082-aaokc182	225	21	Chapter	chapter	NN
cord-302082-aaokc182	225	22	2	2	CD
cord-302082-aaokc182	225	23	e	e	NN
cord-302082-aaokc182	225	24	Vaccine	vaccine	NN
cord-302082-aaokc182	225	25	immunology	immunology	NN
cord-302082-aaokc182	225	26	)	)	-RRB-
cord-302082-aaokc182	225	27	.	.	.
cord-302082-aaokc182	226	1	Safety	safety	NN
cord-302082-aaokc182	226	2	concerns	concern	NNS
cord-302082-aaokc182	226	3	regarding	regard	VBG
cord-302082-aaokc182	226	4	the	the	DT
cord-302082-aaokc182	226	5	potential	potential	NN
cord-302082-aaokc182	226	6	of	of	IN
cord-302082-aaokc182	226	7	vaccines	vaccine	NNS
cord-302082-aaokc182	226	8	to	to	TO
cord-302082-aaokc182	226	9	trigger	trigger	VB
cord-302082-aaokc182	226	10	or	or	CC
cord-302082-aaokc182	226	11	prime	prime	NN
cord-302082-aaokc182	226	12	for	for	IN
cord-302082-aaokc182	226	13	immunopathological	immunopathological	JJ
cord-302082-aaokc182	226	14	responses	response	NNS
cord-302082-aaokc182	226	15	has	have	VBZ
cord-302082-aaokc182	226	16	resulted	result	VBN
cord-302082-aaokc182	226	17	in	in	IN
cord-302082-aaokc182	226	18	a	a	DT
cord-302082-aaokc182	226	19	cautious	cautious	JJ
cord-302082-aaokc182	226	20	approach	approach	NN
cord-302082-aaokc182	226	21	to	to	IN
cord-302082-aaokc182	226	22	the	the	DT
cord-302082-aaokc182	226	23	development	development	NN
cord-302082-aaokc182	226	24	of	of	IN
cord-302082-aaokc182	226	25	RSV	RSV	NNP
cord-302082-aaokc182	226	26	vaccines	vaccine	NNS
cord-302082-aaokc182	226	27	.	.	.
cord-302082-aaokc182	227	1	The	the	DT
cord-302082-aaokc182	227	2	vaccine	vaccine	NN
cord-302082-aaokc182	227	3	candidates	candidate	NNS
cord-302082-aaokc182	227	4	most	most	RBS
cord-302082-aaokc182	227	5	advanced	advanced	JJ
cord-302082-aaokc182	227	6	in	in	IN
cord-302082-aaokc182	227	7	clinical	clinical	JJ
cord-302082-aaokc182	227	8	development	development	NN
cord-302082-aaokc182	227	9	use	use	VBP
cord-302082-aaokc182	227	10	two	two	CD
cord-302082-aaokc182	227	11	different	different	JJ
cord-302082-aaokc182	227	12	approaches	approach	NNS
cord-302082-aaokc182	228	1	e	e	LS
cord-302082-aaokc182	228	2	one	one	NN
cord-302082-aaokc182	228	3	uses	use	VBZ
cord-302082-aaokc182	228	4	a	a	DT
cord-302082-aaokc182	228	5	live	live	JJ
cord-302082-aaokc182	228	6	,	,	,
cord-302082-aaokc182	228	7	attenuated	attenuated	JJ
cord-302082-aaokc182	228	8	virus	virus	NN
cord-302082-aaokc182	228	9	with	with	IN
cord-302082-aaokc182	228	10	a	a	DT
cord-302082-aaokc182	228	11	gene	gene	NN
cord-302082-aaokc182	228	12	deletion	deletion	NN
cord-302082-aaokc182	228	13	deliberately	deliberately	RB
cord-302082-aaokc182	228	14	targeted	target	VBD
cord-302082-aaokc182	228	15	to	to	TO
cord-302082-aaokc182	228	16	minimise	minimise	VB
cord-302082-aaokc182	228	17	immunopathological	immunopathological	JJ
cord-302082-aaokc182	228	18	responses	response	NNS
cord-302082-aaokc182	228	19	.	.	.
cord-302082-aaokc182	229	1	The	the	DT
cord-302082-aaokc182	229	2	other	other	JJ
cord-302082-aaokc182	229	3	approach	approach	NN
cord-302082-aaokc182	229	4	uses	use	VBZ
cord-302082-aaokc182	229	5	a	a	DT
cord-302082-aaokc182	229	6	live	live	JJ
cord-302082-aaokc182	229	7	viral	viral	JJ
cord-302082-aaokc182	229	8	vector	vector	NN
cord-302082-aaokc182	229	9	to	to	TO
cord-302082-aaokc182	229	10	deliver	deliver	VB
cord-302082-aaokc182	229	11	only	only	RB
cord-302082-aaokc182	229	12	a	a	DT
cord-302082-aaokc182	229	13	key	key	JJ
cord-302082-aaokc182	229	14	RSV	RSV	NNP
cord-302082-aaokc182	229	15	surface	surface	NN
cord-302082-aaokc182	229	16	antigen	antigen	NN
cord-302082-aaokc182	229	17	,	,	,
cord-302082-aaokc182	229	18	thereby	thereby	RB
cord-302082-aaokc182	229	19	avoiding	avoid	VBG
cord-302082-aaokc182	229	20	the	the	DT
cord-302082-aaokc182	229	21	risk	risk	NN
cord-302082-aaokc182	229	22	of	of	IN
cord-302082-aaokc182	229	23	an	an	DT
cord-302082-aaokc182	229	24	immunopathological	immunopathological	JJ
cord-302082-aaokc182	229	25	response	response	NN
cord-302082-aaokc182	229	26	arising	arise	VBG
cord-302082-aaokc182	229	27	from	from	IN
cord-302082-aaokc182	229	28	exposure	exposure	NN
cord-302082-aaokc182	229	29	to	to	IN
cord-302082-aaokc182	229	30	the	the	DT
cord-302082-aaokc182	229	31	RSV	RSV	NNP
cord-302082-aaokc182	229	32	virus	virus	NN
cord-302082-aaokc182	229	33	itself	-PRON-	PRP
cord-302082-aaokc182	229	34	.	.	.
cord-302082-aaokc182	230	1	Infectious	infectious	JJ
cord-302082-aaokc182	230	2	illnesses	illness	NNS
cord-302082-aaokc182	230	3	exert	exert	VBP
cord-302082-aaokc182	230	4	a	a	DT
cord-302082-aaokc182	230	5	major	major	JJ
cord-302082-aaokc182	230	6	burden	burden	NN
cord-302082-aaokc182	230	7	of	of	IN
cord-302082-aaokc182	230	8	disease	disease	NN
cord-302082-aaokc182	230	9	in	in	IN
cord-302082-aaokc182	230	10	developing	develop	VBG
cord-302082-aaokc182	230	11	countries	country	NNS
cord-302082-aaokc182	230	12	.	.	.
cord-302082-aaokc182	231	1	The	the	DT
cord-302082-aaokc182	231	2	greatest	great	JJS
cord-302082-aaokc182	231	3	burden	burden	NN
cord-302082-aaokc182	231	4	is	be	VBZ
cord-302082-aaokc182	231	5	caused	cause	VBN
cord-302082-aaokc182	231	6	by	by	IN
cord-302082-aaokc182	231	7	diseases	disease	NNS
cord-302082-aaokc182	231	8	for	for	IN
cord-302082-aaokc182	231	9	which	which	WDT
cord-302082-aaokc182	231	10	we	-PRON-	PRP
cord-302082-aaokc182	231	11	currently	currently	RB
cord-302082-aaokc182	231	12	have	have	VBP
cord-302082-aaokc182	231	13	no	no	DT
cord-302082-aaokc182	231	14	vaccines	vaccine	NNS
cord-302082-aaokc182	231	15	,	,	,
cord-302082-aaokc182	231	16	eg	eg	IN
cord-302082-aaokc182	231	17	taeniid	taeniid	NNP
cord-302082-aaokc182	231	18	cestode	cestode	NNP
cord-302082-aaokc182	231	19	parasites	parasite	NNS
cord-302082-aaokc182	231	20	are	be	VBP
cord-302082-aaokc182	231	21	associated	associate	VBN
cord-302082-aaokc182	231	22	with	with	IN
cord-302082-aaokc182	231	23	high	high	JJ
cord-302082-aaokc182	231	24	human	human	JJ
cord-302082-aaokc182	231	25	morbidity	morbidity	NN
cord-302082-aaokc182	231	26	and	and	CC
cord-302082-aaokc182	231	27	losses	loss	NNS
cord-302082-aaokc182	231	28	in	in	IN
cord-302082-aaokc182	231	29	livestock	livestock	NN
cord-302082-aaokc182	231	30	.	.	.
cord-302082-aaokc182	232	1	Global	global	JJ
cord-302082-aaokc182	232	2	efforts	effort	NNS
cord-302082-aaokc182	232	3	to	to	TO
cord-302082-aaokc182	232	4	reduce	reduce	VB
cord-302082-aaokc182	232	5	these	these	DT
cord-302082-aaokc182	232	6	infections	infection	NNS
cord-302082-aaokc182	232	7	in	in	IN
cord-302082-aaokc182	232	8	humans	human	NNS
cord-302082-aaokc182	232	9	are	be	VBP
cord-302082-aaokc182	232	10	ongoing	ongoe	VBG
cord-302082-aaokc182	232	11	through	through	IN
cord-302082-aaokc182	232	12	the	the	DT
cord-302082-aaokc182	232	13	use	use	NN
cord-302082-aaokc182	232	14	of	of	IN
cord-302082-aaokc182	232	15	antihelminthics	antihelminthic	NNS
cord-302082-aaokc182	232	16	and	and	CC
cord-302082-aaokc182	232	17	the	the	DT
cord-302082-aaokc182	232	18	implementation	implementation	NN
cord-302082-aaokc182	232	19	of	of	IN
cord-302082-aaokc182	232	20	lifestyle	lifestyle	NN
cord-302082-aaokc182	232	21	changes	change	NNS
cord-302082-aaokc182	232	22	,	,	,
cord-302082-aaokc182	232	23	but	but	CC
cord-302082-aaokc182	232	24	this	this	DT
cord-302082-aaokc182	232	25	is	be	VBZ
cord-302082-aaokc182	232	26	having	have	VBG
cord-302082-aaokc182	232	27	little	little	JJ
cord-302082-aaokc182	232	28	effect	effect	NN
cord-302082-aaokc182	232	29	.	.	.
cord-302082-aaokc182	233	1	However	however	RB
cord-302082-aaokc182	233	2	,	,	,
cord-302082-aaokc182	233	3	substantial	substantial	JJ
cord-302082-aaokc182	233	4	progress	progress	NN
cord-302082-aaokc182	233	5	has	have	VBZ
cord-302082-aaokc182	233	6	been	be	VBN
cord-302082-aaokc182	233	7	made	make	VBN
cord-302082-aaokc182	233	8	towards	towards	IN
cord-302082-aaokc182	233	9	developing	develop	VBG
cord-302082-aaokc182	233	10	veterinary	veterinary	JJ
cord-302082-aaokc182	233	11	vaccines	vaccine	NNS
cord-302082-aaokc182	233	12	which	which	WDT
cord-302082-aaokc182	233	13	encourages	encourage	VBZ
cord-302082-aaokc182	233	14	investigation	investigation	NN
cord-302082-aaokc182	233	15	of	of	IN
cord-302082-aaokc182	233	16	the	the	DT
cord-302082-aaokc182	233	17	potential	potential	JJ
cord-302082-aaokc182	233	18	use	use	NN
cord-302082-aaokc182	233	19	of	of	IN
cord-302082-aaokc182	233	20	similar	similar	JJ
cord-302082-aaokc182	233	21	vaccines	vaccine	NNS
cord-302082-aaokc182	233	22	in	in	IN
cord-302082-aaokc182	233	23	humans	human	NNS
cord-302082-aaokc182	233	24	to	to	TO
cord-302082-aaokc182	233	25	prevent	prevent	VB
cord-302082-aaokc182	233	26	,	,	,
cord-302082-aaokc182	233	27	for	for	IN
cord-302082-aaokc182	233	28	example	example	NN
cord-302082-aaokc182	233	29	,	,	,
cord-302082-aaokc182	233	30	hydatid	hydatid	NNP
cord-302082-aaokc182	233	31	disease	disease	NNP
cord-302082-aaokc182	233	32	(	(	-LRB-
cord-302082-aaokc182	233	33	arising	arise	VBG
cord-302082-aaokc182	233	34	from	from	IN
cord-302082-aaokc182	233	35	infection	infection	NN
cord-302082-aaokc182	233	36	with	with	IN
cord-302082-aaokc182	233	37	Echinococcus	Echinococcus	NNP
cord-302082-aaokc182	233	38	granulosus	granulosus	NNP
cord-302082-aaokc182	233	39	)	)	-RRB-
cord-302082-aaokc182	233	40	and	and	CC
cord-302082-aaokc182	233	41	cysticercosis	cysticercosis	NNP
cord-302082-aaokc182	233	42	(	(	-LRB-
cord-302082-aaokc182	233	43	from	from	IN
cord-302082-aaokc182	233	44	infection	infection	NN
cord-302082-aaokc182	233	45	with	with	IN
cord-302082-aaokc182	233	46	Taenia	Taenia	NNP
cord-302082-aaokc182	233	47	solium	solium	NN
cord-302082-aaokc182	233	48	)	)	-RRB-
cord-302082-aaokc182	233	49	.	.	.
cord-302082-aaokc182	234	1	Relative	relative	JJ
cord-302082-aaokc182	234	2	to	to	IN
cord-302082-aaokc182	234	3	their	-PRON-	PRP$
cord-302082-aaokc182	234	4	burden	burden	NN
cord-302082-aaokc182	234	5	on	on	IN
cord-302082-aaokc182	234	6	society	society	NN
cord-302082-aaokc182	234	7	,	,	,
cord-302082-aaokc182	234	8	such	such	JJ
cord-302082-aaokc182	234	9	diseases	disease	NNS
cord-302082-aaokc182	234	10	have	have	VBP
cord-302082-aaokc182	234	11	a	a	DT
cord-302082-aaokc182	234	12	low	low	JJ
cord-302082-aaokc182	234	13	priority	priority	NN
cord-302082-aaokc182	234	14	for	for	IN
cord-302082-aaokc182	234	15	funding	funding	NN
cord-302082-aaokc182	234	16	.	.	.
cord-302082-aaokc182	235	1	Unless	unless	IN
cord-302082-aaokc182	235	2	comprehensive	comprehensive	JJ
cord-302082-aaokc182	235	3	measures	measure	NNS
cord-302082-aaokc182	235	4	are	be	VBP
cord-302082-aaokc182	235	5	taken	take	VBN
cord-302082-aaokc182	235	6	to	to	TO
cord-302082-aaokc182	235	7	address	address	VB
cord-302082-aaokc182	235	8	the	the	DT
cord-302082-aaokc182	235	9	gaps	gap	NNS
cord-302082-aaokc182	235	10	in	in	IN
cord-302082-aaokc182	235	11	funding	funding	NN
cord-302082-aaokc182	235	12	,	,	,
cord-302082-aaokc182	235	13	research	research	NN
cord-302082-aaokc182	235	14	and	and	CC
cord-302082-aaokc182	235	15	global	global	JJ
cord-302082-aaokc182	235	16	immunisation	immunisation	NN
cord-302082-aaokc182	235	17	coverage	coverage	NN
cord-302082-aaokc182	235	18	,	,	,
cord-302082-aaokc182	235	19	developing	develop	VBG
cord-302082-aaokc182	235	20	countries	country	NNS
cord-302082-aaokc182	235	21	will	will	MD
cord-302082-aaokc182	235	22	continue	continue	VB
cord-302082-aaokc182	235	23	to	to	TO
cord-302082-aaokc182	235	24	be	be	VB
cord-302082-aaokc182	235	25	overwhelmed	overwhelm	VBN
cord-302082-aaokc182	235	26	by	by	IN
cord-302082-aaokc182	235	27	some	some	DT
cord-302082-aaokc182	235	28	of	of	IN
cord-302082-aaokc182	235	29	the	the	DT
cord-302082-aaokc182	235	30	most	most	RBS
cord-302082-aaokc182	235	31	devastating	devastating	JJ
cord-302082-aaokc182	235	32	diseases	disease	NNS
cord-302082-aaokc182	235	33	.	.	.
cord-302082-aaokc182	236	1	In	in	IN
cord-302082-aaokc182	236	2	order	order	NN
cord-302082-aaokc182	236	3	to	to	TO
cord-302082-aaokc182	236	4	improve	improve	VB
cord-302082-aaokc182	236	5	the	the	DT
cord-302082-aaokc182	236	6	situation	situation	NN
cord-302082-aaokc182	236	7	,	,	,
cord-302082-aaokc182	236	8	collaborative	collaborative	JJ
cord-302082-aaokc182	236	9	schemes	scheme	NNS
cord-302082-aaokc182	236	10	are	be	VBP
cord-302082-aaokc182	236	11	underway	underway	JJ
cord-302082-aaokc182	236	12	that	that	IN
cord-302082-aaokc182	236	13	bring	bring	VBP
cord-302082-aaokc182	236	14	together	together	RB
cord-302082-aaokc182	236	15	academic	academic	JJ
cord-302082-aaokc182	236	16	institutions	institution	NNS
cord-302082-aaokc182	236	17	,	,	,
cord-302082-aaokc182	236	18	industry	industry	NN
cord-302082-aaokc182	236	19	and	and	CC
cord-302082-aaokc182	236	20	public	public	JJ
cord-302082-aaokc182	236	21	/	/	SYM
cord-302082-aaokc182	236	22	charitable	charitable	JJ
cord-302082-aaokc182	236	23	financing	financing	NN
cord-302082-aaokc182	236	24	organisations	organisation	NNS
cord-302082-aaokc182	236	25	.	.	.
cord-302082-aaokc182	236	26	 	 	_SP
cord-302082-aaokc182	237	1	Microbiome	Microbiome	NNP
cord-302082-aaokc182	237	2	Project	Project	NNP
cord-302082-aaokc182	237	3	is	be	VBZ
cord-302082-aaokc182	237	4	a	a	DT
cord-302082-aaokc182	237	5	National	National	NNP
cord-302082-aaokc182	237	6	Institutes	Institutes	NNPS
cord-302082-aaokc182	237	7	of	of	IN
cord-302082-aaokc182	237	8	Health	Health	NNP
cord-302082-aaokc182	237	9	initiative	initiative	NN
cord-302082-aaokc182	237	10	that	that	WDT
cord-302082-aaokc182	237	11	seeks	seek	VBZ
cord-302082-aaokc182	237	12	to	to	TO
cord-302082-aaokc182	237	13	determine	determine	VB
cord-302082-aaokc182	237	14	the	the	DT
cord-302082-aaokc182	237	15	relationship	relationship	NN
cord-302082-aaokc182	237	16	between	between	IN
cord-302082-aaokc182	237	17	human	human	JJ
cord-302082-aaokc182	237	18	health	health	NN
cord-302082-aaokc182	237	19	and	and	CC
cord-302082-aaokc182	237	20	changes	change	NNS
cord-302082-aaokc182	237	21	in	in	IN
cord-302082-aaokc182	237	22	the	the	DT
cord-302082-aaokc182	237	23	human	human	JJ
cord-302082-aaokc182	237	24	microbiome	microbiome	NN
cord-302082-aaokc182	237	25	.	.	.
cord-302082-aaokc182	238	1	By	by	IN
cord-302082-aaokc182	238	2	using	use	VBG
cord-302082-aaokc182	238	3	revolutionary	revolutionary	JJ
cord-302082-aaokc182	238	4	sequencing	sequencing	NN
cord-302082-aaokc182	238	5	technologies	technology	NNS
cord-302082-aaokc182	238	6	to	to	TO
cord-302082-aaokc182	238	7	characterise	characterise	VB
cord-302082-aaokc182	238	8	the	the	DT
cord-302082-aaokc182	238	9	microbiology	microbiology	NN
cord-302082-aaokc182	238	10	of	of	IN
cord-302082-aaokc182	238	11	five	five	CD
cord-302082-aaokc182	238	12	body	body	NN
cord-302082-aaokc182	238	13	sites	site	NNS
cord-302082-aaokc182	238	14	e	e	LS
cord-302082-aaokc182	238	15	oral	oral	JJ
cord-302082-aaokc182	238	16	cavity	cavity	NN
cord-302082-aaokc182	238	17	,	,	,
cord-302082-aaokc182	238	18	skin	skin	NN
cord-302082-aaokc182	238	19	,	,	,
cord-302082-aaokc182	238	20	vagina	vagina	NN
cord-302082-aaokc182	238	21	,	,	,
cord-302082-aaokc182	238	22	gut	gut	NN
cord-302082-aaokc182	238	23	and	and	CC
cord-302082-aaokc182	238	24	nasal	nasal	NN
cord-302082-aaokc182	239	1	tract	tract	NNP
cord-302082-aaokc182	239	2	/	/	SYM
cord-302082-aaokc182	239	3	lung	lung	NN
cord-302082-aaokc182	239	4	e	e	NN
cord-302082-aaokc182	240	1	an	an	DT
cord-302082-aaokc182	240	2	association	association	NN
cord-302082-aaokc182	240	3	may	may	MD
cord-302082-aaokc182	240	4	be	be	VB
cord-302082-aaokc182	240	5	made	make	VBN
cord-302082-aaokc182	240	6	between	between	IN
cord-302082-aaokc182	240	7	the	the	DT
cord-302082-aaokc182	240	8	microbiomes	microbiome	NNS
cord-302082-aaokc182	240	9	associated	associate	VBN
cord-302082-aaokc182	240	10	with	with	IN
cord-302082-aaokc182	240	11	either	either	CC
cord-302082-aaokc182	240	12	the	the	DT
cord-302082-aaokc182	240	13	healthy	healthy	JJ
cord-302082-aaokc182	240	14	body	body	NN
cord-302082-aaokc182	240	15	state	state	NN
cord-302082-aaokc182	240	16	or	or	CC
cord-302082-aaokc182	240	17	disease	disease	NN
cord-302082-aaokc182	240	18	.	.	.
cord-302082-aaokc182	241	1	Characterising	characterise	VBG
cord-302082-aaokc182	241	2	microbes	microbe	NNS
cord-302082-aaokc182	241	3	associated	associate	VBN
cord-302082-aaokc182	241	4	with	with	IN
cord-302082-aaokc182	241	5	disease	disease	NN
cord-302082-aaokc182	241	6	-	-	HYPH
cord-302082-aaokc182	241	7	related	relate	VBN
cord-302082-aaokc182	241	8	pathogens	pathogen	NNS
cord-302082-aaokc182	241	9	may	may	MD
cord-302082-aaokc182	241	10	allow	allow	VB
cord-302082-aaokc182	241	11	for	for	IN
cord-302082-aaokc182	241	12	the	the	DT
cord-302082-aaokc182	241	13	development	development	NN
cord-302082-aaokc182	241	14	of	of	IN
cord-302082-aaokc182	241	15	new	new	JJ
cord-302082-aaokc182	241	16	vaccines	vaccine	NNS
cord-302082-aaokc182	241	17	that	that	WDT
cord-302082-aaokc182	241	18	preserve	preserve	VBP
cord-302082-aaokc182	241	19	or	or	CC
cord-302082-aaokc182	241	20	protect	protect	VB
cord-302082-aaokc182	241	21	the	the	DT
cord-302082-aaokc182	241	22	healthy	healthy	JJ
cord-302082-aaokc182	241	23	microbiome	microbiome	NN
cord-302082-aaokc182	241	24	and	and	CC
cord-302082-aaokc182	241	25	hence	hence	RB
cord-302082-aaokc182	241	26	could	could	MD
cord-302082-aaokc182	241	27	protect	protect	VB
cord-302082-aaokc182	241	28	human	human	JJ
cord-302082-aaokc182	241	29	health	health	NN
cord-302082-aaokc182	241	30	.	.	.
cord-302082-aaokc182	242	1	Some	some	DT
cord-302082-aaokc182	242	2	of	of	IN
cord-302082-aaokc182	242	3	the	the	DT
cord-302082-aaokc182	242	4	areas	area	NNS
cord-302082-aaokc182	242	5	of	of	IN
cord-302082-aaokc182	242	6	current	current	JJ
cord-302082-aaokc182	242	7	research	research	NN
cord-302082-aaokc182	242	8	are	be	VBP
cord-302082-aaokc182	242	9	outlined	outline	VBN
cord-302082-aaokc182	242	10	in	in	IN
cord-302082-aaokc182	242	11	the	the	DT
cord-302082-aaokc182	242	12	box	box	NN
cord-302082-aaokc182	242	13	,	,	,
cord-302082-aaokc182	242	14	right	right	UH
cord-302082-aaokc182	242	15	.	.	.
cord-302082-aaokc182	243	1	Some	some	DT
cord-302082-aaokc182	243	2	conditions	condition	NNS
cord-302082-aaokc182	243	3	traditionally	traditionally	RB
cord-302082-aaokc182	243	4	thought	think	VBD
cord-302082-aaokc182	243	5	of	of	IN
cord-302082-aaokc182	243	6	as	as	IN
cord-302082-aaokc182	243	7	non	non	JJ
cord-302082-aaokc182	243	8	-	-	JJ
cord-302082-aaokc182	243	9	infectious	infectious	JJ
cord-302082-aaokc182	243	10	may	may	NN
cord-302082-aaokc182	243	11	in	in	IN
cord-302082-aaokc182	243	12	fact	fact	NN
cord-302082-aaokc182	243	13	have	have	VB
cord-302082-aaokc182	243	14	infectious	infectious	JJ
cord-302082-aaokc182	243	15	origins	origin	NNS
cord-302082-aaokc182	243	16	(	(	-LRB-
cord-302082-aaokc182	243	17	Table	table	NN
cord-302082-aaokc182	243	18	6	6	CD
cord-302082-aaokc182	243	19	.12	.12	CD
cord-302082-aaokc182	243	20	)	)	-RRB-
cord-302082-aaokc182	243	21	;	;	:
cord-302082-aaokc182	243	22	therefore	therefore	RB
cord-302082-aaokc182	243	23	,	,	,
cord-302082-aaokc182	243	24	vaccination	vaccination	NN
cord-302082-aaokc182	243	25	could	could	MD
cord-302082-aaokc182	243	26	be	be	VB
cord-302082-aaokc182	243	27	a	a	DT
cord-302082-aaokc182	243	28	strategy	strategy	NN
cord-302082-aaokc182	243	29	to	to	TO
cord-302082-aaokc182	243	30	prevent	prevent	VB
cord-302082-aaokc182	243	31	these	these	DT
cord-302082-aaokc182	243	32	diseases	disease	NNS
cord-302082-aaokc182	243	33	.	.	.
cord-302082-aaokc182	244	1	Other	other	JJ
cord-302082-aaokc182	244	2	diseases	disease	NNS
cord-302082-aaokc182	244	3	may	may	MD
cord-302082-aaokc182	244	4	result	result	VB
cord-302082-aaokc182	244	5	from	from	IN
cord-302082-aaokc182	244	6	an	an	DT
cord-302082-aaokc182	244	7	interaction	interaction	NN
cord-302082-aaokc182	244	8	between	between	IN
cord-302082-aaokc182	244	9	the	the	DT
cord-302082-aaokc182	244	10	host	host	NN
cord-302082-aaokc182	244	11	's	's	POS
cord-302082-aaokc182	244	12	genetic	genetic	JJ
cord-302082-aaokc182	244	13	background	background	NN
cord-302082-aaokc182	244	14	and	and	CC
cord-302082-aaokc182	244	15	a	a	DT
cord-302082-aaokc182	244	16	particular	particular	JJ
cord-302082-aaokc182	244	17	microbe	microbe	NN
cord-302082-aaokc182	244	18	(	(	-LRB-
cord-302082-aaokc182	244	19	a	a	DT
cord-302082-aaokc182	244	20	so	so	RB
cord-302082-aaokc182	244	21	-	-	HYPH
cord-302082-aaokc182	244	22	called	call	VBN
cord-302082-aaokc182	244	23	gene	gene	NN
cord-302082-aaokc182	244	24	-	-	HYPH
cord-302082-aaokc182	244	25	environment	environment	NN
cord-302082-aaokc182	244	26	interaction	interaction	NN
cord-302082-aaokc182	244	27	)	)	-RRB-
cord-302082-aaokc182	244	28	.	.	.
cord-302082-aaokc182	245	1	Some	some	DT
cord-302082-aaokc182	245	2	diseases	disease	NNS
cord-302082-aaokc182	245	3	have	have	VBP
cord-302082-aaokc182	245	4	an	an	DT
cord-302082-aaokc182	245	5	established	establish	VBN
cord-302082-aaokc182	245	6	link	link	NN
cord-302082-aaokc182	245	7	with	with	IN
cord-302082-aaokc182	245	8	an	an	DT
cord-302082-aaokc182	245	9	identified	identify	VBN
cord-302082-aaokc182	245	10	infectious	infectious	JJ
cord-302082-aaokc182	245	11	agent	agent	NN
cord-302082-aaokc182	245	12	.	.	.
cord-302082-aaokc182	246	1	For	for	IN
cord-302082-aaokc182	246	2	example	example	NN
cord-302082-aaokc182	246	3	,	,	,
cord-302082-aaokc182	246	4	primary	primary	JJ
cord-302082-aaokc182	246	5	CMV	CMV	NNP
cord-302082-aaokc182	246	6	infection	infection	NN
cord-302082-aaokc182	246	7	is	be	VBZ
cord-302082-aaokc182	246	8	a	a	DT
cord-302082-aaokc182	246	9	known	known	JJ
cord-302082-aaokc182	246	10	cause	cause	NN
cord-302082-aaokc182	246	11	of	of	IN
cord-302082-aaokc182	246	12	congenital	congenital	JJ
cord-302082-aaokc182	246	13	mental	mental	JJ
cord-302082-aaokc182	246	14	retardation	retardation	NN
cord-302082-aaokc182	246	15	;	;	:
cord-302082-aaokc182	246	16	similarly	similarly	RB
cord-302082-aaokc182	246	17	the	the	DT
cord-302082-aaokc182	246	18	link	link	NN
cord-302082-aaokc182	246	19	between	between	IN
cord-302082-aaokc182	246	20	bacterial	bacterial	JJ
cord-302082-aaokc182	246	21	vaginosis	vaginosis	NN
cord-302082-aaokc182	246	22	and	and	CC
cord-302082-aaokc182	246	23	foetal	foetal	JJ
cord-302082-aaokc182	246	24	prematurity	prematurity	NN
cord-302082-aaokc182	246	25	is	be	VBZ
cord-302082-aaokc182	246	26	widely	widely	RB
cord-302082-aaokc182	246	27	accepted	accept	VBN
cord-302082-aaokc182	246	28	.	.	.
cord-302082-aaokc182	247	1	While	while	IN
cord-302082-aaokc182	247	2	some	some	DT
cord-302082-aaokc182	247	3	links	link	NNS
cord-302082-aaokc182	247	4	have	have	VBP
cord-302082-aaokc182	247	5	been	be	VBN
cord-302082-aaokc182	247	6	established	establish	VBN
cord-302082-aaokc182	247	7	,	,	,
cord-302082-aaokc182	247	8	others	other	NNS
cord-302082-aaokc182	247	9	remain	remain	VBP
cord-302082-aaokc182	247	10	speculative	speculative	JJ
cord-302082-aaokc182	247	11	(	(	-LRB-
cord-302082-aaokc182	247	12	Table	table	NN
cord-302082-aaokc182	247	13	6	6	CD
cord-302082-aaokc182	247	14	.12	.12	CD
cord-302082-aaokc182	247	15	)	)	-RRB-
cord-302082-aaokc182	247	16	.	.	.
cord-302082-aaokc182	248	1	Candidate	candidate	NN
cord-302082-aaokc182	248	2	vaccines	vaccine	NNS
cord-302082-aaokc182	248	3	are	be	VBP
cord-302082-aaokc182	248	4	in	in	IN
cord-302082-aaokc182	248	5	development	development	NN
cord-302082-aaokc182	248	6	for	for	IN
cord-302082-aaokc182	248	7	the	the	DT
cord-302082-aaokc182	248	8	prevention	prevention	NN
cord-302082-aaokc182	248	9	and	and	CC
cord-302082-aaokc182	248	10	treatment	treatment	NN
cord-302082-aaokc182	248	11	of	of	IN
cord-302082-aaokc182	248	12	various	various	JJ
cord-302082-aaokc182	248	13	types	type	NNS
cord-302082-aaokc182	248	14	of	of	IN
cord-302082-aaokc182	248	15	addiction	addiction	NN
cord-302082-aaokc182	248	16	.	.	.
cord-302082-aaokc182	249	1	The	the	DT
cord-302082-aaokc182	249	2	basic	basic	JJ
cord-302082-aaokc182	249	3	concept	concept	NN
cord-302082-aaokc182	249	4	is	be	VBZ
cord-302082-aaokc182	249	5	to	to	TO
cord-302082-aaokc182	249	6	induce	induce	VB
cord-302082-aaokc182	249	7	the	the	DT
cord-302082-aaokc182	249	8	production	production	NN
cord-302082-aaokc182	249	9	of	of	IN
cord-302082-aaokc182	249	10	antibodies	antibody	NNS
cord-302082-aaokc182	249	11	which	which	WDT
cord-302082-aaokc182	249	12	will	will	MD
cord-302082-aaokc182	249	13	bind	bind	VB
cord-302082-aaokc182	249	14	the	the	DT
cord-302082-aaokc182	249	15	drug	drug	NN
cord-302082-aaokc182	249	16	and	and	CC
cord-302082-aaokc182	249	17	impede	impede	VB
cord-302082-aaokc182	249	18	its	-PRON-	PRP$
cord-302082-aaokc182	249	19	crossing	cross	VBG
cord-302082-aaokc182	249	20	the	the	DT
cord-302082-aaokc182	249	21	bloodebrain	bloodebrain	NNP
cord-302082-aaokc182	249	22	barrier	barrier	NN
cord-302082-aaokc182	249	23	to	to	TO
cord-302082-aaokc182	249	24	exert	exert	VB
cord-302082-aaokc182	249	25	its	-PRON-	PRP$
cord-302082-aaokc182	249	26	psychoactive	psychoactive	JJ
cord-302082-aaokc182	249	27	effects	effect	NNS
cord-302082-aaokc182	249	28	.	.	.
cord-302082-aaokc182	250	1	Several	several	JJ
cord-302082-aaokc182	250	2	nicotine	nicotine	NN
cord-302082-aaokc182	250	3	candidate	candidate	NN
cord-302082-aaokc182	250	4	vaccines	vaccine	NNS
cord-302082-aaokc182	250	5	have	have	VBP
cord-302082-aaokc182	250	6	now	now	RB
cord-302082-aaokc182	250	7	entered	enter	VBN
cord-302082-aaokc182	250	8	clinical	clinical	JJ
cord-302082-aaokc182	250	9	trials	trial	NNS
cord-302082-aaokc182	250	10	.	.	.
cord-302082-aaokc182	251	1	A	a	DT
cord-302082-aaokc182	251	2	cocaine	cocaine	NN
cord-302082-aaokc182	251	3	candidate	candidate	NN
cord-302082-aaokc182	251	4	vaccine	vaccine	NN
cord-302082-aaokc182	251	5	has	have	VBZ
cord-302082-aaokc182	251	6	also	also	RB
cord-302082-aaokc182	251	7	shown	show	VBN
cord-302082-aaokc182	251	8	some	some	DT
cord-302082-aaokc182	251	9	benefit	benefit	NN
cord-302082-aaokc182	251	10	in	in	IN
cord-302082-aaokc182	251	11	a	a	DT
cord-302082-aaokc182	251	12	Phase	phase	NN
cord-302082-aaokc182	251	13	IIb	iib	NN
cord-302082-aaokc182	251	14	clinical	clinical	JJ
cord-302082-aaokc182	251	15	trial	trial	NN
cord-302082-aaokc182	251	16	.	.	.
cord-302082-aaokc182	252	1	The	the	DT
cord-302082-aaokc182	252	2	key	key	JJ
cord-302082-aaokc182	252	3	issue	issue	NN
cord-302082-aaokc182	252	4	to	to	IN
cord-302082-aaokc182	252	5	date	date	NN
cord-302082-aaokc182	252	6	for	for	IN
cord-302082-aaokc182	252	7	both	both	CC
cord-302082-aaokc182	252	8	nicotine	nicotine	NN
cord-302082-aaokc182	252	9	and	and	CC
cord-302082-aaokc182	252	10	cocaine	cocaine	NN
cord-302082-aaokc182	252	11	candidate	candidate	NN
cord-302082-aaokc182	252	12	vaccines	vaccine	NNS
cord-302082-aaokc182	252	13	has	have	VBZ
cord-302082-aaokc182	252	14	been	be	VBN
cord-302082-aaokc182	252	15	to	to	TO
cord-302082-aaokc182	252	16	induce	induce	VB
cord-302082-aaokc182	252	17	 	 	_SP
cord-302082-aaokc182	252	18	Continued	Continued	NNP
cord-302082-aaokc182	252	19	on	on	IN
cord-302082-aaokc182	252	20	next	next	JJ
cord-302082-aaokc182	252	21	page	page	NN
cord-302082-aaokc182	252	22	high	high	JJ
cord-302082-aaokc182	252	23	immunoglobulin	immunoglobulin	NN
cord-302082-aaokc182	252	24	(	(	-LRB-
cord-302082-aaokc182	252	25	Ig)G	Ig)G	NNP
cord-302082-aaokc182	252	26	anti	anti	JJ
cord-302082-aaokc182	252	27	-	-	JJ
cord-302082-aaokc182	252	28	drug	drug	JJ
cord-302082-aaokc182	252	29	antibody	antibody	NN
cord-302082-aaokc182	252	30	levels	level	NNS
cord-302082-aaokc182	252	31	,	,	,
cord-302082-aaokc182	252	32	which	which	WDT
cord-302082-aaokc182	252	33	appear	appear	VBP
cord-302082-aaokc182	252	34	to	to	TO
cord-302082-aaokc182	252	35	be	be	VB
cord-302082-aaokc182	252	36	critical	critical	JJ
cord-302082-aaokc182	252	37	in	in	IN
cord-302082-aaokc182	252	38	achieving	achieve	VBG
cord-302082-aaokc182	252	39	some	some	DT
cord-302082-aaokc182	252	40	degree	degree	NN
cord-302082-aaokc182	252	41	of	of	IN
cord-302082-aaokc182	252	42	efficacy	efficacy	NN
cord-302082-aaokc182	252	43	.	.	.
cord-302082-aaokc182	253	1	Candidate	candidate	NN
cord-302082-aaokc182	253	2	vaccines	vaccine	NNS
cord-302082-aaokc182	253	3	against	against	IN
cord-302082-aaokc182	253	4	methamphetamine	methamphetamine	NN
cord-302082-aaokc182	253	5	addiction	addiction	NN
cord-302082-aaokc182	253	6	are	be	VBP
cord-302082-aaokc182	253	7	also	also	RB
cord-302082-aaokc182	253	8	in	in	IN
cord-302082-aaokc182	253	9	early	early	JJ
cord-302082-aaokc182	253	10	development	development	NN
cord-302082-aaokc182	253	11	.	.	.
cord-302082-aaokc182	254	1	To	to	IN
cord-302082-aaokc182	254	2	date	date	NN
cord-302082-aaokc182	254	3	,	,	,
cord-302082-aaokc182	254	4	the	the	DT
cord-302082-aaokc182	254	5	approach	approach	NN
cord-302082-aaokc182	254	6	to	to	IN
cord-302082-aaokc182	254	7	developing	develop	VBG
cord-302082-aaokc182	254	8	prophylactic	prophylactic	JJ
cord-302082-aaokc182	254	9	cancer	cancer	NN
cord-302082-aaokc182	254	10	vaccines	vaccine	NNS
cord-302082-aaokc182	254	11	has	have	VBZ
cord-302082-aaokc182	254	12	been	be	VBN
cord-302082-aaokc182	254	13	to	to	TO
cord-302082-aaokc182	254	14	target	target	VB
cord-302082-aaokc182	254	15	infectious	infectious	JJ
cord-302082-aaokc182	254	16	diseases	disease	NNS
cord-302082-aaokc182	254	17	that	that	WDT
cord-302082-aaokc182	254	18	cause	cause	VBP
cord-302082-aaokc182	254	19	or	or	CC
cord-302082-aaokc182	254	20	contribute	contribute	VB
cord-302082-aaokc182	254	21	to	to	IN
cord-302082-aaokc182	254	22	the	the	DT
cord-302082-aaokc182	254	23	development	development	NN
cord-302082-aaokc182	254	24	of	of	IN
cord-302082-aaokc182	254	25	cancer	cancer	NN
cord-302082-aaokc182	254	26	such	such	JJ
cord-302082-aaokc182	254	27	as	as	IN
cord-302082-aaokc182	254	28	HPV	HPV	NNP
cord-302082-aaokc182	254	29	(	(	-LRB-
cord-302082-aaokc182	254	30	cervical	cervical	JJ
cord-302082-aaokc182	254	31	cancer	cancer	NN
cord-302082-aaokc182	254	32	)	)	-RRB-
cord-302082-aaokc182	254	33	and	and	CC
cord-302082-aaokc182	254	34	HBV	HBV	NNP
cord-302082-aaokc182	254	35	(	(	-LRB-
cord-302082-aaokc182	254	36	hepatocellular	hepatocellular	JJ
cord-302082-aaokc182	254	37	carcinoma	carcinoma	NN
cord-302082-aaokc182	254	38	)	)	-RRB-
cord-302082-aaokc182	254	39	.	.	.
cord-302082-aaokc182	255	1	Examples	example	NNS
cord-302082-aaokc182	255	2	of	of	IN
cord-302082-aaokc182	255	3	infectious	infectious	JJ
cord-302082-aaokc182	255	4	diseases	disease	NNS
cord-302082-aaokc182	255	5	associated	associate	VBN
cord-302082-aaokc182	255	6	with	with	IN
cord-302082-aaokc182	255	7	cancer	cancer	NN
cord-302082-aaokc182	255	8	are	be	VBP
cord-302082-aaokc182	255	9	shown	show	VBN
cord-302082-aaokc182	255	10	in	in	IN
cord-302082-aaokc182	255	11	Table	Table	NNP
cord-302082-aaokc182	255	12	6	6	CD
cord-302082-aaokc182	255	13	.13	.13	NFP
cord-302082-aaokc182	255	14	.	.	.
cord-302082-aaokc182	256	1	The	the	DT
cord-302082-aaokc182	256	2	successful	successful	JJ
cord-302082-aaokc182	256	3	development	development	NN
cord-302082-aaokc182	256	4	of	of	IN
cord-302082-aaokc182	256	5	a	a	DT
cord-302082-aaokc182	256	6	nicotine	nicotine	NN
cord-302082-aaokc182	256	7	vaccine	vaccine	NN
cord-302082-aaokc182	256	8	would	would	MD
cord-302082-aaokc182	256	9	be	be	VB
cord-302082-aaokc182	256	10	expected	expect	VBN
cord-302082-aaokc182	256	11	to	to	TO
cord-302082-aaokc182	256	12	reduce	reduce	VB
cord-302082-aaokc182	256	13	cigarette	cigarette	NN
cord-302082-aaokc182	256	14	smoking	smoking	NN
cord-302082-aaokc182	256	15	-	-	HYPH
cord-302082-aaokc182	256	16	related	relate	VBN
cord-302082-aaokc182	256	17	lung	lung	NN
cord-302082-aaokc182	256	18	cancer	cancer	NN
cord-302082-aaokc182	256	19	.	.	.
cord-302082-aaokc182	257	1	Some	some	DT
cord-302082-aaokc182	257	2	cancers	cancer	NNS
cord-302082-aaokc182	257	3	express	express	VBP
cord-302082-aaokc182	257	4	tissue	tissue	NN
cord-302082-aaokc182	257	5	-	-	HYPH
cord-302082-aaokc182	257	6	specific	specific	JJ
cord-302082-aaokc182	257	7	antigens	antigen	NNS
cord-302082-aaokc182	257	8	that	that	WDT
cord-302082-aaokc182	257	9	can	can	MD
cord-302082-aaokc182	257	10	be	be	VB
cord-302082-aaokc182	257	11	targeted	target	VBN
cord-302082-aaokc182	257	12	by	by	IN
cord-302082-aaokc182	257	13	the	the	DT
cord-302082-aaokc182	257	14	immune	immune	JJ
cord-302082-aaokc182	257	15	system	system	NN
cord-302082-aaokc182	257	16	.	.	.
cord-302082-aaokc182	258	1	Therapeutic	therapeutic	JJ
cord-302082-aaokc182	258	2	cancer	cancer	NN
cord-302082-aaokc182	258	3	vaccines	vaccine	NNS
cord-302082-aaokc182	258	4	aim	aim	VBP
cord-302082-aaokc182	258	5	to	to	TO
cord-302082-aaokc182	258	6	target	target	VB
cord-302082-aaokc182	258	7	tumour	tumour	NN
cord-302082-aaokc182	258	8	-	-	HYPH
cord-302082-aaokc182	258	9	associated	associate	VBN
cord-302082-aaokc182	258	10	antigens	antigen	NNS
cord-302082-aaokc182	258	11	(	(	-LRB-
cord-302082-aaokc182	258	12	TAA	TAA	NNP
cord-302082-aaokc182	258	13	)	)	-RRB-
cord-302082-aaokc182	258	14	with	with	IN
cord-302082-aaokc182	258	15	T	t	NN
cord-302082-aaokc182	258	16	-	-	HYPH
cord-302082-aaokc182	258	17	cell	cell	NN
cord-302082-aaokc182	258	18	mediated	mediate	VBN
cord-302082-aaokc182	258	19	immune	immune	JJ
cord-302082-aaokc182	258	20	responses	response	NNS
cord-302082-aaokc182	258	21	.	.	.
cord-302082-aaokc182	259	1	TAA	TAA	NNP
cord-302082-aaokc182	259	2	can	can	MD
cord-302082-aaokc182	259	3	be	be	VB
cord-302082-aaokc182	259	4	related	relate	VBN
cord-302082-aaokc182	259	5	to	to	IN
cord-302082-aaokc182	259	6	the	the	DT
cord-302082-aaokc182	259	7	genetic	genetic	JJ
cord-302082-aaokc182	259	8	changes	change	NNS
cord-302082-aaokc182	259	9	that	that	WDT
cord-302082-aaokc182	259	10	drive	drive	VBP
cord-302082-aaokc182	259	11	the	the	DT
cord-302082-aaokc182	259	12	cancer	cancer	NN
cord-302082-aaokc182	259	13	(	(	-LRB-
cord-302082-aaokc182	259	14	eg	eg	IN
cord-302082-aaokc182	259	15	Ras	Ras	NNP
cord-302082-aaokc182	259	16	oncogene	oncogene	NN
cord-302082-aaokc182	259	17	)	)	-RRB-
cord-302082-aaokc182	259	18	,	,	,
cord-302082-aaokc182	259	19	or	or	CC
cord-302082-aaokc182	259	20	inappropriate	inappropriate	JJ
cord-302082-aaokc182	259	21	up	up	RP
cord-302082-aaokc182	259	22	-	-	HYPH
cord-302082-aaokc182	259	23	regulation/	regulation/	CD
cord-302082-aaokc182	259	24	expression	expression	NN
cord-302082-aaokc182	259	25	of	of	IN
cord-302082-aaokc182	259	26	genes	gene	NNS
cord-302082-aaokc182	259	27	(	(	-LRB-
cord-302082-aaokc182	259	28	eg	eg	IN
cord-302082-aaokc182	259	29	carcinoembryonic	carcinoembryonic	NNP
cord-302082-aaokc182	259	30	antigen	antigen	NNP
cord-302082-aaokc182	259	31	)	)	-RRB-
cord-302082-aaokc182	259	32	.	.	.
cord-302082-aaokc182	260	1	With	with	IN
cord-302082-aaokc182	260	2	such	such	JJ
cord-302082-aaokc182	260	3	TAA	TAA	NNP
cord-302082-aaokc182	260	4	targets	target	NNS
cord-302082-aaokc182	260	5	,	,	,
cord-302082-aaokc182	260	6	vaccines	vaccine	NNS
cord-302082-aaokc182	260	7	aim	aim	VBP
cord-302082-aaokc182	260	8	to	to	TO
cord-302082-aaokc182	260	9	maximally	maximally	RB
cord-302082-aaokc182	260	10	stimulate	stimulate	VB
cord-302082-aaokc182	260	11	a	a	DT
cord-302082-aaokc182	260	12	cytotoxic	cytotoxic	JJ
cord-302082-aaokc182	260	13	T	t	NN
cord-302082-aaokc182	260	14	-	-	HYPH
cord-302082-aaokc182	260	15	cell	cell	NN
cord-302082-aaokc182	260	16	response	response	NN
cord-302082-aaokc182	260	17	and	and	CC
cord-302082-aaokc182	260	18	their	-PRON-	PRP$
cord-302082-aaokc182	260	19	design	design	NN
cord-302082-aaokc182	260	20	often	often	RB
cord-302082-aaokc182	260	21	includes	include	VBZ
cord-302082-aaokc182	260	22	adjuvants	adjuvant	NNS
cord-302082-aaokc182	260	23	to	to	TO
cord-302082-aaokc182	260	24	enhance	enhance	VB
cord-302082-aaokc182	260	25	antigen	antigen	NN
cord-302082-aaokc182	260	26	presentation	presentation	NN
cord-302082-aaokc182	260	27	.	.	.
cord-302082-aaokc182	261	1	Tumours	tumour	NNS
cord-302082-aaokc182	261	2	develop	develop	VBP
cord-302082-aaokc182	261	3	in	in	IN
cord-302082-aaokc182	261	4	a	a	DT
cord-302082-aaokc182	261	5	multistep	multistep	JJ
cord-302082-aaokc182	261	6	process	process	NN
cord-302082-aaokc182	261	7	in	in	IN
cord-302082-aaokc182	261	8	the	the	DT
cord-302082-aaokc182	261	9	face	face	NN
cord-302082-aaokc182	261	10	of	of	IN
cord-302082-aaokc182	261	11	the	the	DT
cord-302082-aaokc182	261	12	host	host	NN
cord-302082-aaokc182	261	13	immune	immune	JJ
cord-302082-aaokc182	261	14	response	response	NN
cord-302082-aaokc182	261	15	and	and	CC
cord-302082-aaokc182	261	16	frequently	frequently	RB
cord-302082-aaokc182	261	17	evolve	evolve	VBP
cord-302082-aaokc182	261	18	to	to	TO
cord-302082-aaokc182	261	19	escape	escape	VB
cord-302082-aaokc182	261	20	immune	immune	JJ
cord-302082-aaokc182	261	21	control	control	NN
cord-302082-aaokc182	261	22	.	.	.
cord-302082-aaokc182	262	1	Mechanisms	mechanism	NNS
cord-302082-aaokc182	262	2	of	of	IN
cord-302082-aaokc182	262	3	evasion	evasion	NN
cord-302082-aaokc182	262	4	include	include	VBP
cord-302082-aaokc182	262	5	genetic	genetic	JJ
cord-302082-aaokc182	262	6	changes	change	NNS
cord-302082-aaokc182	262	7	(	(	-LRB-
cord-302082-aaokc182	262	8	loss	loss	NN
cord-302082-aaokc182	262	9	of	of	IN
cord-302082-aaokc182	262	10	human	human	JJ
cord-302082-aaokc182	262	11	leukocyte	leukocyte	NN
cord-302082-aaokc182	262	12	antigen	antigen	NNP
cord-302082-aaokc182	262	13	/	/	SYM
cord-302082-aaokc182	262	14	TAA	TAA	NNP
cord-302082-aaokc182	262	15	expression	expression	NN
cord-302082-aaokc182	262	16	)	)	-RRB-
cord-302082-aaokc182	262	17	and	and	CC
cord-302082-aaokc182	262	18	induction	induction	NN
cord-302082-aaokc182	262	19	of	of	IN
cord-302082-aaokc182	262	20	immune	immune	JJ
cord-302082-aaokc182	262	21	regulatory	regulatory	JJ
cord-302082-aaokc182	262	22	systems	system	NNS
cord-302082-aaokc182	262	23	(	(	-LRB-
cord-302082-aaokc182	262	24	T	t	NN
cord-302082-aaokc182	262	25	-	-	HYPH
cord-302082-aaokc182	262	26	cell	cell	NN
cord-302082-aaokc182	262	27	anergy	anergy	NN
cord-302082-aaokc182	262	28	due	due	IN
cord-302082-aaokc182	262	29	to	to	IN
cord-302082-aaokc182	262	30	the	the	DT
cord-302082-aaokc182	262	31	activity	activity	NN
cord-302082-aaokc182	262	32	of	of	IN
cord-302082-aaokc182	262	33	 	 	_SP
cord-302082-aaokc182	262	34	T	T	NNP
cord-302082-aaokc182	262	35	reg	reg	NNP
cord-302082-aaokc182	262	36	cells	cell	NNS
cord-302082-aaokc182	262	37	)	)	-RRB-
cord-302082-aaokc182	262	38	which	which	WDT
cord-302082-aaokc182	262	39	limit	limit	VBP
cord-302082-aaokc182	262	40	anti	anti	JJ
cord-302082-aaokc182	262	41	-	-	JJ
cord-302082-aaokc182	262	42	tumour	tumour	JJ
cord-302082-aaokc182	262	43	immunity	immunity	NN
cord-302082-aaokc182	262	44	.	.	.
cord-302082-aaokc182	263	1	The	the	DT
cord-302082-aaokc182	263	2	key	key	JJ
cord-302082-aaokc182	263	3	approach	approach	NN
cord-302082-aaokc182	263	4	for	for	IN
cord-302082-aaokc182	263	5	therapeutic	therapeutic	JJ
cord-302082-aaokc182	263	6	cancer	cancer	NN
cord-302082-aaokc182	263	7	vaccines	vaccine	NNS
cord-302082-aaokc182	263	8	is	be	VBZ
cord-302082-aaokc182	263	9	resetting	reset	VBG
cord-302082-aaokc182	263	10	the	the	DT
cord-302082-aaokc182	263	11	immune	immune	JJ
cord-302082-aaokc182	263	12	response	response	NN
cord-302082-aaokc182	263	13	to	to	TO
cord-302082-aaokc182	263	14	deliver	deliver	VB
cord-302082-aaokc182	263	15	anti	anti	JJ
cord-302082-aaokc182	263	16	-	-	JJ
cord-302082-aaokc182	263	17	tumour	tumour	JJ
cord-302082-aaokc182	263	18	immunity	immunity	NN
cord-302082-aaokc182	263	19	that	that	WDT
cord-302082-aaokc182	263	20	alters	alter	VBZ
cord-302082-aaokc182	263	21	or	or	CC
cord-302082-aaokc182	263	22	destroys	destroy	VBZ
cord-302082-aaokc182	263	23	cancer	cancer	NN
cord-302082-aaokc182	263	24	cells	cell	NNS
cord-302082-aaokc182	263	25	and	and	CC
cord-302082-aaokc182	263	26	hence	hence	RB
cord-302082-aaokc182	263	27	eliminates	eliminate	VBZ
cord-302082-aaokc182	263	28	or	or	CC
cord-302082-aaokc182	263	29	reduces	reduce	VBZ
cord-302082-aaokc182	263	30	the	the	DT
cord-302082-aaokc182	263	31	tumour	tumour	NN
cord-302082-aaokc182	263	32	.	.	.
cord-302082-aaokc182	264	1	One	one	CD
cord-302082-aaokc182	264	2	strategy	strategy	NN
cord-302082-aaokc182	264	3	uses	use	VBZ
cord-302082-aaokc182	264	4	the	the	DT
cord-302082-aaokc182	264	5	patient	patient	NN
cord-302082-aaokc182	264	6	's	's	POS
cord-302082-aaokc182	264	7	own	own	JJ
cord-302082-aaokc182	264	8	tumour	tumour	NN
cord-302082-aaokc182	264	9	as	as	IN
cord-302082-aaokc182	264	10	the	the	DT
cord-302082-aaokc182	264	11	immunogen	immunogen	NN
cord-302082-aaokc182	264	12	,	,	,
cord-302082-aaokc182	264	13	thereby	thereby	RB
cord-302082-aaokc182	264	14	providing	provide	VBG
cord-302082-aaokc182	264	15	all	all	PDT
cord-302082-aaokc182	264	16	the	the	DT
cord-302082-aaokc182	264	17	potential	potential	JJ
cord-302082-aaokc182	264	18	idiotypic	idiotypic	JJ
cord-302082-aaokc182	264	19	changes	change	NNS
cord-302082-aaokc182	264	20	that	that	WDT
cord-302082-aaokc182	264	21	might	may	MD
cord-302082-aaokc182	264	22	act	act	VB
cord-302082-aaokc182	264	23	as	as	IN
cord-302082-aaokc182	264	24	TAA	TAA	NNP
cord-302082-aaokc182	264	25	,	,	,
cord-302082-aaokc182	264	26	in	in	IN
cord-302082-aaokc182	264	27	conjunction	conjunction	NN
cord-302082-aaokc182	264	28	with	with	IN
cord-302082-aaokc182	264	29	antigen	antigen	NN
cord-302082-aaokc182	264	30	-	-	HYPH
cord-302082-aaokc182	264	31	presenting	present	VBG
cord-302082-aaokc182	264	32	DCs	dc	NNS
cord-302082-aaokc182	264	33	harvested	harvest	VBN
cord-302082-aaokc182	264	34	from	from	IN
cord-302082-aaokc182	264	35	the	the	DT
cord-302082-aaokc182	264	36	same	same	JJ
cord-302082-aaokc182	264	37	patient	patient	NN
cord-302082-aaokc182	264	38	and	and	CC
cord-302082-aaokc182	264	39	activated	activate	VBN
cord-302082-aaokc182	264	40	in	in	IN
cord-302082-aaokc182	264	41	vitro	vitro	FW
cord-302082-aaokc182	264	42	(	(	-LRB-
cord-302082-aaokc182	264	43	see	see	VB
cord-302082-aaokc182	264	44	Dendritic	dendritic	JJ
cord-302082-aaokc182	264	45	cell	cell	NN
cord-302082-aaokc182	264	46	vaccines	vaccine	NNS
cord-302082-aaokc182	264	47	)	)	-RRB-
cord-302082-aaokc182	264	48	.	.	.
cord-302082-aaokc182	265	1	There	there	EX
cord-302082-aaokc182	265	2	are	be	VBP
cord-302082-aaokc182	265	3	different	different	JJ
cord-302082-aaokc182	265	4	types	type	NNS
cord-302082-aaokc182	265	5	of	of	IN
cord-302082-aaokc182	265	6	therapeutic	therapeutic	JJ
cord-302082-aaokc182	265	7	candidate	candidate	NN
cord-302082-aaokc182	265	8	vaccines	vaccine	NNS
cord-302082-aaokc182	265	9	currently	currently	RB
cord-302082-aaokc182	265	10	undergoing	undergo	VBG
cord-302082-aaokc182	265	11	clinical	clinical	JJ
cord-302082-aaokc182	265	12	trials	trial	NNS
cord-302082-aaokc182	265	13	for	for	IN
cord-302082-aaokc182	265	14	numerous	numerous	JJ
cord-302082-aaokc182	265	15	types	type	NNS
cord-302082-aaokc182	265	16	of	of	IN
cord-302082-aaokc182	265	17	cancer	cancer	NN
cord-302082-aaokc182	265	18	(	(	-LRB-
cord-302082-aaokc182	265	19	Table	table	NN
cord-302082-aaokc182	265	20	6	6	CD
cord-302082-aaokc182	265	21	.14	.14	NFP
cord-302082-aaokc182	265	22	)	)	-RRB-
cord-302082-aaokc182	265	23	.	.	.
cord-302082-aaokc182	266	1	The	the	DT
cord-302082-aaokc182	266	2	most	most	RBS
cord-302082-aaokc182	266	3	advanced	advanced	JJ
cord-302082-aaokc182	266	4	candidates	candidate	NNS
cord-302082-aaokc182	266	5	currently	currently	RB
cord-302082-aaokc182	266	6	in	in	IN
cord-302082-aaokc182	266	7	Phase	Phase	NNP
cord-302082-aaokc182	266	8	III	III	NNP
cord-302082-aaokc182	266	9	are	be	VBP
cord-302082-aaokc182	266	10	described	describe	VBN
cord-302082-aaokc182	266	11	in	in	IN
cord-302082-aaokc182	266	12	Chapter	chapter	NN
cord-302082-aaokc182	266	13	4	4	CD
cord-302082-aaokc182	266	14	e	e	NN
cord-302082-aaokc182	266	15	Vaccine	vaccine	NN
cord-302082-aaokc182	266	16	adjuvants	adjuvant	NNS
cord-302082-aaokc182	266	17	.	.	.
cord-302082-aaokc182	267	1	There	there	EX
cord-302082-aaokc182	267	2	has	have	VBZ
cord-302082-aaokc182	267	3	been	be	VBN
cord-302082-aaokc182	267	4	some	some	DT
cord-302082-aaokc182	267	5	success	success	NN
cord-302082-aaokc182	267	6	in	in	IN
cord-302082-aaokc182	267	7	the	the	DT
cord-302082-aaokc182	267	8	development	development	NN
cord-302082-aaokc182	267	9	of	of	IN
cord-302082-aaokc182	267	10	therapeutic	therapeutic	JJ
cord-302082-aaokc182	267	11	cancer	cancer	NN
cord-302082-aaokc182	267	12	vaccines	vaccine	NNS
cord-302082-aaokc182	267	13	,	,	,
cord-302082-aaokc182	267	14	with	with	IN
cord-302082-aaokc182	267	15	the	the	DT
cord-302082-aaokc182	267	16	FDA	FDA	NNP
cord-302082-aaokc182	267	17	approval	approval	NN
cord-302082-aaokc182	267	18	of	of	IN
cord-302082-aaokc182	267	19	the	the	DT
cord-302082-aaokc182	267	20	first	first	JJ
cord-302082-aaokc182	267	21	DC	DC	NNP
cord-302082-aaokc182	267	22	vaccine	vaccine	NN
cord-302082-aaokc182	267	23	Oxford	Oxford	NNP
cord-302082-aaokc182	267	24	BioMedica	BioMedica	NNP
cord-302082-aaokc182	267	25	MUC1	MUC1	NNP
cord-302082-aaokc182	267	26	,	,	,
cord-302082-aaokc182	267	27	Mucin	mucin	NN
cord-302082-aaokc182	267	28	1	1	CD
cord-302082-aaokc182	267	29	cell	cell	NN
cord-302082-aaokc182	267	30	surface	surface	NN
cord-302082-aaokc182	267	31	;	;	:
cord-302082-aaokc182	267	32	hIL2	hIL2	NNP
cord-302082-aaokc182	267	33	,	,	,
cord-302082-aaokc182	267	34	human	human	JJ
cord-302082-aaokc182	267	35	cytokine	cytokine	NN
cord-302082-aaokc182	267	36	interleukin-2	interleukin-2	XX
cord-302082-aaokc182	267	37	;	;	:
cord-302082-aaokc182	267	38	ASCI	ASCI	NNP
cord-302082-aaokc182	267	39	,	,	,
cord-302082-aaokc182	267	40	antigen	antigen	NN
cord-302082-aaokc182	267	41	-	-	HYPH
cord-302082-aaokc182	267	42	specific	specific	JJ
cord-302082-aaokc182	267	43	cancer	cancer	NN
cord-302082-aaokc182	267	44	immunotherapeutics	immunotherapeutic	NNS
cord-302082-aaokc182	267	45	;	;	:
cord-302082-aaokc182	267	46	MAGE	MAGE	NNP
cord-302082-aaokc182	267	47	,	,	,
cord-302082-aaokc182	267	48	melanomaassociated	melanomaassociate	VBD
cord-302082-aaokc182	267	49	antigen	antigen	NN
cord-302082-aaokc182	267	50	;	;	:
cord-302082-aaokc182	267	51	CTL	CTL	NNP
cord-302082-aaokc182	267	52	,	,	,
cord-302082-aaokc182	267	53	cytotoxic	cytotoxic	JJ
cord-302082-aaokc182	267	54	T	t	NN
cord-302082-aaokc182	267	55	lymphocyte	lymphocyte	NN
cord-302082-aaokc182	267	56	.	.	.
cord-302082-aaokc182	268	1	Every	every	DT
cord-302082-aaokc182	268	2	effort	effort	NN
cord-302082-aaokc182	268	3	has	have	VBZ
cord-302082-aaokc182	268	4	been	be	VBN
cord-302082-aaokc182	268	5	made	make	VBN
cord-302082-aaokc182	268	6	to	to	TO
cord-302082-aaokc182	268	7	verify	verify	VB
cord-302082-aaokc182	268	8	the	the	DT
cord-302082-aaokc182	268	9	information	information	NN
cord-302082-aaokc182	268	10	in	in	IN
cord-302082-aaokc182	268	11	this	this	DT
cord-302082-aaokc182	268	12	table	table	NN
cord-302082-aaokc182	268	13	.	.	.
cord-302082-aaokc182	269	1	The	the	DT
cord-302082-aaokc182	269	2	information	information	NN
cord-302082-aaokc182	269	3	included	include	VBD
cord-302082-aaokc182	269	4	is	be	VBZ
cord-302082-aaokc182	269	5	not	not	RB
cord-302082-aaokc182	269	6	meant	mean	VBN
cord-302082-aaokc182	269	7	to	to	TO
cord-302082-aaokc182	269	8	be	be	VB
cord-302082-aaokc182	269	9	exhaustive	exhaustive	JJ
cord-302082-aaokc182	269	10	but	but	CC
cord-302082-aaokc182	269	11	is	be	VBZ
cord-302082-aaokc182	269	12	intended	intend	VBN
cord-302082-aaokc182	269	13	to	to	TO
cord-302082-aaokc182	269	14	provide	provide	VB
cord-302082-aaokc182	269	15	an	an	DT
cord-302082-aaokc182	269	16	overview	overview	NN
cord-302082-aaokc182	269	17	of	of	IN
cord-302082-aaokc182	269	18	the	the	DT
cord-302082-aaokc182	269	19	subject	subject	JJ
cord-302082-aaokc182	269	20	matter	matter	NN
cord-302082-aaokc182	269	21	.	.	.
cord-302082-aaokc182	270	1	vaccine	vaccine	NN
cord-302082-aaokc182	270	2	approaches	approach	VBZ
cord-302082-aaokc182	270	3	.	.	.
cord-302082-aaokc182	271	1	However	however	RB
cord-302082-aaokc182	271	2	,	,	,
cord-302082-aaokc182	271	3	this	this	DT
cord-302082-aaokc182	271	4	presents	present	VBZ
cord-302082-aaokc182	271	5	opportunities	opportunity	NNS
cord-302082-aaokc182	271	6	for	for	IN
cord-302082-aaokc182	271	7	the	the	DT
cord-302082-aaokc182	271	8	application	application	NN
cord-302082-aaokc182	271	9	of	of	IN
cord-302082-aaokc182	271	10	novel	novel	JJ
cord-302082-aaokc182	271	11	technologies	technology	NNS
cord-302082-aaokc182	271	12	and	and	CC
cord-302082-aaokc182	271	13	adjuvants	adjuvant	NNS
cord-302082-aaokc182	271	14	.	.	.
cord-302082-aaokc182	272	1	Some	some	DT
cord-302082-aaokc182	272	2	of	of	IN
cord-302082-aaokc182	272	3	the	the	DT
cord-302082-aaokc182	272	4	considerations	consideration	NNS
cord-302082-aaokc182	272	5	for	for	IN
cord-302082-aaokc182	272	6	vaccines	vaccine	NNS
cord-302082-aaokc182	272	7	designed	design	VBN
cord-302082-aaokc182	272	8	for	for	IN
cord-302082-aaokc182	272	9	use	use	NN
cord-302082-aaokc182	272	10	in	in	IN
cord-302082-aaokc182	272	11	special	special	JJ
cord-302082-aaokc182	272	12	populations	population	NNS
cord-302082-aaokc182	272	13	include	include	VBP
cord-302082-aaokc182	272	14	:	:	:
cord-302082-aaokc182	272	15	immunosenescence	immunosenescence	VB
cord-302082-aaokc182	272	16	in	in	IN
cord-302082-aaokc182	272	17	the	the	DT
cord-302082-aaokc182	272	18	elderly	elderly	JJ
cord-302082-aaokc182	272	19	;	;	:
cord-302082-aaokc182	272	20	the	the	DT
cord-302082-aaokc182	272	21	poor	poor	JJ
cord-302082-aaokc182	272	22	immunological	immunological	JJ
cord-302082-aaokc182	272	23	response	response	NN
cord-302082-aaokc182	272	24	to	to	IN
cord-302082-aaokc182	272	25	traditional	traditional	JJ
cord-302082-aaokc182	272	26	vaccines	vaccine	NNS
cord-302082-aaokc182	272	27	seen	see	VBN
cord-302082-aaokc182	272	28	in	in	IN
cord-302082-aaokc182	272	29	immunocompromised	immunocompromised	JJ
cord-302082-aaokc182	272	30	individuals	individual	NNS
cord-302082-aaokc182	272	31	(	(	-LRB-
cord-302082-aaokc182	272	32	patients	patient	NNS
cord-302082-aaokc182	272	33	with	with	IN
cord-302082-aaokc182	272	34	HIV	HIV	NNP
cord-302082-aaokc182	272	35	,	,	,
cord-302082-aaokc182	272	36	transplant	transplant	NN
cord-302082-aaokc182	272	37	recipients	recipient	NNS
cord-302082-aaokc182	272	38	)	)	-RRB-
cord-302082-aaokc182	272	39	;	;	:
cord-302082-aaokc182	272	40	the	the	DT
cord-302082-aaokc182	272	41	crossing	crossing	NN
cord-302082-aaokc182	272	42	of	of	IN
cord-302082-aaokc182	272	43	vaccine	vaccine	NN
cord-302082-aaokc182	272	44	components	component	NNS
cord-302082-aaokc182	272	45	into	into	IN
cord-302082-aaokc182	272	46	the	the	DT
cord-302082-aaokc182	272	47	foetal	foetal	JJ
cord-302082-aaokc182	272	48	bloodstream	bloodstream	NN
cord-302082-aaokc182	272	49	when	when	WRB
cord-302082-aaokc182	272	50	vaccines	vaccine	NNS
cord-302082-aaokc182	272	51	are	be	VBP
cord-302082-aaokc182	272	52	administered	administer	VBN
cord-302082-aaokc182	272	53	to	to	IN
cord-302082-aaokc182	272	54	pregnant	pregnant	JJ
cord-302082-aaokc182	272	55	women	woman	NNS
cord-302082-aaokc182	272	56	;	;	:
cord-302082-aaokc182	272	57	and	and	CC
cord-302082-aaokc182	272	58	the	the	DT
cord-302082-aaokc182	272	59	safety	safety	NN
cord-302082-aaokc182	272	60	and	and	CC
cord-302082-aaokc182	272	61	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	272	62	concerns	concern	NNS
cord-302082-aaokc182	272	63	surrounding	surround	VBG
cord-302082-aaokc182	272	64	vaccines	vaccine	NNS
cord-302082-aaokc182	272	65	for	for	IN
cord-302082-aaokc182	272	66	neonates	neonate	NNS
cord-302082-aaokc182	272	67	due	due	JJ
cord-302082-aaokc182	272	68	to	to	IN
cord-302082-aaokc182	272	69	their	-PRON-	PRP$
cord-302082-aaokc182	272	70	naïve	naïve	JJ
cord-302082-aaokc182	272	71	and	and	CC
cord-302082-aaokc182	272	72	immature	immature	JJ
cord-302082-aaokc182	272	73	immune	immune	JJ
cord-302082-aaokc182	272	74	system	system	NN
cord-302082-aaokc182	272	75	.	.	.
cord-302082-aaokc182	273	1	Cell	cell	NN
cord-302082-aaokc182	273	2	-	-	HYPH
cord-302082-aaokc182	273	3	mediated	mediate	VBN
cord-302082-aaokc182	273	4	immunity	immunity	NN
cord-302082-aaokc182	273	5	is	be	VBZ
cord-302082-aaokc182	273	6	depressed	depress	VBN
cord-302082-aaokc182	273	7	in	in	IN
cord-302082-aaokc182	273	8	pregnant	pregnant	JJ
cord-302082-aaokc182	273	9	women	woman	NNS
cord-302082-aaokc182	273	10	,	,	,
cord-302082-aaokc182	273	11	leaving	leave	VBG
cord-302082-aaokc182	273	12	them	-PRON-	PRP
cord-302082-aaokc182	273	13	at	at	IN
cord-302082-aaokc182	273	14	high	high	JJ
cord-302082-aaokc182	273	15	risk	risk	NN
cord-302082-aaokc182	273	16	of	of	IN
cord-302082-aaokc182	273	17	infection	infection	NN
cord-302082-aaokc182	273	18	from	from	IN
cord-302082-aaokc182	273	19	pathogens	pathogen	NNS
cord-302082-aaokc182	273	20	,	,	,
cord-302082-aaokc182	273	21	including	include	VBG
cord-302082-aaokc182	273	22	those	those	DT
cord-302082-aaokc182	273	23	harmful	harmful	JJ
cord-302082-aaokc182	273	24	to	to	IN
cord-302082-aaokc182	273	25	the	the	DT
cord-302082-aaokc182	273	26	foetus	foetus	NN
cord-302082-aaokc182	273	27	.	.	.
cord-302082-aaokc182	274	1	Most	Most	JJS
cord-302082-aaokc182	274	2	live	live	VBP
cord-302082-aaokc182	274	3	,	,	,
cord-302082-aaokc182	274	4	attenuated	attenuated	JJ
cord-302082-aaokc182	274	5	vaccines	vaccine	NNS
cord-302082-aaokc182	274	6	are	be	VBP
cord-302082-aaokc182	274	7	contraindicated	contraindicated	JJ
cord-302082-aaokc182	274	8	during	during	IN
cord-302082-aaokc182	274	9	pregnancy	pregnancy	NN
cord-302082-aaokc182	274	10	because	because	IN
cord-302082-aaokc182	274	11	of	of	IN
cord-302082-aaokc182	274	12	the	the	DT
cord-302082-aaokc182	274	13	theoretical	theoretical	JJ
cord-302082-aaokc182	274	14	risk	risk	NN
cord-302082-aaokc182	274	15	of	of	IN
cord-302082-aaokc182	274	16	foetal	foetal	JJ
cord-302082-aaokc182	274	17	infection	infection	NN
cord-302082-aaokc182	274	18	from	from	IN
cord-302082-aaokc182	274	19	the	the	DT
cord-302082-aaokc182	274	20	vaccine	vaccine	NN
cord-302082-aaokc182	274	21	.	.	.
cord-302082-aaokc182	275	1	However	however	RB
cord-302082-aaokc182	275	2	,	,	,
cord-302082-aaokc182	275	3	inactivated	inactivate	VBN
cord-302082-aaokc182	275	4	viral	viral	JJ
cord-302082-aaokc182	275	5	or	or	CC
cord-302082-aaokc182	275	6	bacterial	bacterial	JJ
cord-302082-aaokc182	275	7	vaccines	vaccine	NNS
cord-302082-aaokc182	275	8	can	can	MD
cord-302082-aaokc182	275	9	be	be	VB
cord-302082-aaokc182	275	10	administered	administer	VBN
cord-302082-aaokc182	275	11	.	.	.
cord-302082-aaokc182	276	1	Pregnant	pregnant	JJ
cord-302082-aaokc182	276	2	women	woman	NNS
cord-302082-aaokc182	276	3	can	can	MD
cord-302082-aaokc182	276	4	,	,	,
cord-302082-aaokc182	276	5	therefore	therefore	RB
cord-302082-aaokc182	276	6	,	,	,
cord-302082-aaokc182	276	7	be	be	VB
cord-302082-aaokc182	276	8	vaccinated	vaccinate	VBN
cord-302082-aaokc182	276	9	against	against	IN
cord-302082-aaokc182	276	10	some	some	DT
cord-302082-aaokc182	276	11	infections	infection	NNS
cord-302082-aaokc182	276	12	,	,	,
cord-302082-aaokc182	276	13	including	include	VBG
cord-302082-aaokc182	276	14	several	several	JJ
cord-302082-aaokc182	276	15	that	that	DT
cord-302082-aaokc182	276	16	pass	pass	NN
cord-302082-aaokc182	276	17	from	from	IN
cord-302082-aaokc182	276	18	mother	mother	NN
cord-302082-aaokc182	276	19	to	to	IN
cord-302082-aaokc182	276	20	foetus	foetus	NN
cord-302082-aaokc182	276	21	(	(	-LRB-
cord-302082-aaokc182	276	22	such	such	JJ
cord-302082-aaokc182	276	23	as	as	IN
cord-302082-aaokc182	276	24	hepatitis	hepatitis	NNP
cord-302082-aaokc182	276	25	A	A	NNP
cord-302082-aaokc182	276	26	and	and	CC
cord-302082-aaokc182	276	27	B	B	NNP
cord-302082-aaokc182	276	28	)	)	-RRB-
cord-302082-aaokc182	276	29	,	,	,
cord-302082-aaokc182	276	30	and	and	CC
cord-302082-aaokc182	276	31	against	against	IN
cord-302082-aaokc182	276	32	infections	infection	NNS
cord-302082-aaokc182	276	33	acquired	acquire	VBN
cord-302082-aaokc182	276	34	by	by	IN
cord-302082-aaokc182	276	35	the	the	DT
cord-302082-aaokc182	276	36	infant	infant	NN
cord-302082-aaokc182	276	37	in	in	IN
cord-302082-aaokc182	276	38	the	the	DT
cord-302082-aaokc182	276	39	first	first	JJ
cord-302082-aaokc182	276	40	few	few	JJ
cord-302082-aaokc182	276	41	months	month	NNS
cord-302082-aaokc182	276	42	of	of	IN
cord-302082-aaokc182	276	43	life	life	NN
cord-302082-aaokc182	276	44	(	(	-LRB-
cord-302082-aaokc182	276	45	often	often	RB
cord-302082-aaokc182	276	46	from	from	IN
cord-302082-aaokc182	276	47	close	close	JJ
cord-302082-aaokc182	276	48	contact	contact	NN
cord-302082-aaokc182	276	49	with	with	IN
cord-302082-aaokc182	276	50	the	the	DT
cord-302082-aaokc182	276	51	mother	mother	NN
cord-302082-aaokc182	276	52	)	)	-RRB-
cord-302082-aaokc182	276	53	.	.	.
cord-302082-aaokc182	277	1	In	in	IN
cord-302082-aaokc182	277	2	the	the	DT
cord-302082-aaokc182	277	3	latter	latter	JJ
cord-302082-aaokc182	277	4	case	case	NN
cord-302082-aaokc182	277	5	,	,	,
cord-302082-aaokc182	277	6	the	the	DT
cord-302082-aaokc182	277	7	infant	infant	NN
cord-302082-aaokc182	277	8	can	can	MD
cord-302082-aaokc182	277	9	be	be	VB
cord-302082-aaokc182	277	10	protected	protect	VBN
cord-302082-aaokc182	277	11	by	by	IN
cord-302082-aaokc182	277	12	transfer	transfer	NN
cord-302082-aaokc182	277	13	of	of	IN
cord-302082-aaokc182	277	14	maternal	maternal	JJ
cord-302082-aaokc182	277	15	antibodies	antibody	NNS
cord-302082-aaokc182	277	16	during	during	IN
cord-302082-aaokc182	277	17	late	late	JJ
cord-302082-aaokc182	277	18	gestation	gestation	NN
cord-302082-aaokc182	277	19	.	.	.
cord-302082-aaokc182	278	1	Examples	example	NNS
cord-302082-aaokc182	278	2	of	of	IN
cord-302082-aaokc182	278	3	diseases	disease	NNS
cord-302082-aaokc182	278	4	that	that	WDT
cord-302082-aaokc182	278	5	can	can	MD
cord-302082-aaokc182	278	6	be	be	VB
cord-302082-aaokc182	278	7	prevented	prevent	VBN
cord-302082-aaokc182	278	8	in	in	IN
cord-302082-aaokc182	278	9	pregnant	pregnant	JJ
cord-302082-aaokc182	278	10	women	woman	NNS
cord-302082-aaokc182	278	11	include	include	VBP
cord-302082-aaokc182	278	12	influenza	influenza	NN
cord-302082-aaokc182	278	13	,	,	,
cord-302082-aaokc182	278	14	tetanus	tetanus	NN
cord-302082-aaokc182	278	15	,	,	,
cord-302082-aaokc182	278	16	diphtheria	diphtheria	NN
cord-302082-aaokc182	278	17	and	and	CC
cord-302082-aaokc182	278	18	probably	probably	RB
cord-302082-aaokc182	278	19	pertussis	pertussis	NN
cord-302082-aaokc182	278	20	.	.	.
cord-302082-aaokc182	279	1	Other	other	JJ
cord-302082-aaokc182	279	2	diseases	disease	NNS
cord-302082-aaokc182	279	3	,	,	,
cord-302082-aaokc182	279	4	such	such	JJ
cord-302082-aaokc182	279	5	as	as	IN
cord-302082-aaokc182	279	6	those	those	DT
cord-302082-aaokc182	279	7	caused	cause	VBN
cord-302082-aaokc182	279	8	by	by	IN
cord-302082-aaokc182	279	9	the	the	DT
cord-302082-aaokc182	279	10	so	so	RB
cord-302082-aaokc182	279	11	-	-	HYPH
cord-302082-aaokc182	279	12	called	call	VBN
cord-302082-aaokc182	279	13	TORCH	torch	NN
cord-302082-aaokc182	279	14	pathogens	pathogen	NNS
cord-302082-aaokc182	279	15	(	(	-LRB-
cord-302082-aaokc182	279	16	toxoplasma	toxoplasma	NN
cord-302082-aaokc182	279	17	,	,	,
cord-302082-aaokc182	279	18	others	other	NNS
cord-302082-aaokc182	279	19	including	include	VBG
cord-302082-aaokc182	279	20	syphilis	syphili	NNS
cord-302082-aaokc182	279	21	,	,	,
cord-302082-aaokc182	279	22	CMV	CMV	NNP
cord-302082-aaokc182	279	23	and	and	CC
cord-302082-aaokc182	279	24	HSV	HSV	NNP
cord-302082-aaokc182	279	25	)	)	-RRB-
cord-302082-aaokc182	279	26	,	,	,
cord-302082-aaokc182	279	27	are	be	VBP
cord-302082-aaokc182	279	28	not	not	RB
cord-302082-aaokc182	279	29	yet	yet	RB
cord-302082-aaokc182	279	30	preventable	preventable	JJ
cord-302082-aaokc182	279	31	through	through	IN
cord-302082-aaokc182	279	32	vaccination	vaccination	NN
cord-302082-aaokc182	279	33	though	though	IN
cord-302082-aaokc182	279	34	encouraging	encourage	VBG
cord-302082-aaokc182	279	35	Phase	Phase	NNP
cord-302082-aaokc182	279	36	II	II	NNP
cord-302082-aaokc182	279	37	results	result	NNS
cord-302082-aaokc182	279	38	have	have	VBP
cord-302082-aaokc182	279	39	been	be	VBN
cord-302082-aaokc182	279	40	presented	present	VBN
cord-302082-aaokc182	279	41	for	for	IN
cord-302082-aaokc182	279	42	a	a	DT
cord-302082-aaokc182	279	43	vaccine	vaccine	NN
cord-302082-aaokc182	279	44	to	to	TO
cord-302082-aaokc182	279	45	prevent	prevent	VB
cord-302082-aaokc182	279	46	Group	Group	NNP
cord-302082-aaokc182	279	47	B	B	NNP
cord-302082-aaokc182	279	48	streptococcus	streptococcus	NN
cord-302082-aaokc182	279	49	carriage	carriage	NN
cord-302082-aaokc182	279	50	in	in	IN
cord-302082-aaokc182	279	51	pregnant	pregnant	JJ
cord-302082-aaokc182	279	52	women	woman	NNS
cord-302082-aaokc182	279	53	(	(	-LRB-
cord-302082-aaokc182	279	54	Hillier	Hillier	NNP
cord-302082-aaokc182	279	55	et	et	NNP
cord-302082-aaokc182	279	56	al	al	NNP
cord-302082-aaokc182	279	57	.	.	NNP
cord-302082-aaokc182	279	58	,	,	,
cord-302082-aaokc182	279	59	2009	2009	CD
cord-302082-aaokc182	279	60	;	;	:
cord-302082-aaokc182	279	61	Smith	Smith	NNP
cord-302082-aaokc182	279	62	,	,	,
cord-302082-aaokc182	279	63	2009	2009	CD
cord-302082-aaokc182	279	64	)	)	-RRB-
cord-302082-aaokc182	279	65	.	.	.
cord-302082-aaokc182	280	1	The	the	DT
cord-302082-aaokc182	280	2	2009	2009	CD
cord-302082-aaokc182	280	3	H1N1	H1N1	NNP
cord-302082-aaokc182	280	4	pandemic	pandemic	NN
cord-302082-aaokc182	280	5	influenza	influenza	NN
cord-302082-aaokc182	280	6	outbreak	outbreak	NN
cord-302082-aaokc182	280	7	posed	pose	VBD
cord-302082-aaokc182	280	8	an	an	DT
cord-302082-aaokc182	280	9	increased	increase	VBN
cord-302082-aaokc182	280	10	risk	risk	NN
cord-302082-aaokc182	280	11	to	to	IN
cord-302082-aaokc182	280	12	pregnant	pregnant	JJ
cord-302082-aaokc182	280	13	women	woman	NNS
cord-302082-aaokc182	280	14	and	and	CC
cord-302082-aaokc182	280	15	vaccination	vaccination	NN
cord-302082-aaokc182	280	16	was	be	VBD
cord-302082-aaokc182	280	17	specifically	specifically	RB
cord-302082-aaokc182	280	18	recommended	recommend	VBN
cord-302082-aaokc182	280	19	in	in	IN
cord-302082-aaokc182	280	20	pregnant	pregnant	JJ
cord-302082-aaokc182	280	21	women	woman	NNS
cord-302082-aaokc182	280	22	as	as	IN
cord-302082-aaokc182	280	23	one	one	CD
cord-302082-aaokc182	280	24	of	of	IN
cord-302082-aaokc182	280	25	the	the	DT
cord-302082-aaokc182	280	26	high	high	JJ
cord-302082-aaokc182	280	27	-	-	HYPH
cord-302082-aaokc182	280	28	risk	risk	NN
cord-302082-aaokc182	280	29	groups	group	NNS
cord-302082-aaokc182	280	30	.	.	.
cord-302082-aaokc182	281	1	The	the	DT
cord-302082-aaokc182	281	2	pandemic	pandemic	NN
cord-302082-aaokc182	281	3	example	example	NN
cord-302082-aaokc182	281	4	has	have	VBZ
cord-302082-aaokc182	281	5	emphasised	emphasise	VBN
cord-302082-aaokc182	281	6	once	once	RB
cord-302082-aaokc182	281	7	more	more	RBR
cord-302082-aaokc182	281	8	the	the	DT
cord-302082-aaokc182	281	9	importance	importance	NN
cord-302082-aaokc182	281	10	of	of	IN
cord-302082-aaokc182	281	11	protecting	protect	VBG
cord-302082-aaokc182	281	12	pregnant	pregnant	JJ
cord-302082-aaokc182	281	13	women	woman	NNS
cord-302082-aaokc182	281	14	against	against	IN
cord-302082-aaokc182	281	15	influenza	influenza	NN
cord-302082-aaokc182	281	16	.	.	.
cord-302082-aaokc182	282	1	Seasonal	seasonal	JJ
cord-302082-aaokc182	282	2	influenza	influenza	NN
cord-302082-aaokc182	282	3	vaccination	vaccination	NN
cord-302082-aaokc182	282	4	in	in	IN
cord-302082-aaokc182	282	5	pregnancy	pregnancy	NN
cord-302082-aaokc182	282	6	is	be	VBZ
cord-302082-aaokc182	282	7	well	well	RB
cord-302082-aaokc182	282	8	tolerated	tolerate	VBN
cord-302082-aaokc182	282	9	and	and	CC
cord-302082-aaokc182	282	10	the	the	DT
cord-302082-aaokc182	282	11	benefiterisk	benefiterisk	NN
cord-302082-aaokc182	282	12	profile	profile	NN
cord-302082-aaokc182	282	13	when	when	WRB
cord-302082-aaokc182	282	14	administered	administer	VBN
cord-302082-aaokc182	282	15	to	to	IN
cord-302082-aaokc182	282	16	pregnant	pregnant	JJ
cord-302082-aaokc182	282	17	women	woman	NNS
cord-302082-aaokc182	282	18	supports	support	VBZ
cord-302082-aaokc182	282	19	its	-PRON-	PRP$
cord-302082-aaokc182	282	20	use	use	NN
cord-302082-aaokc182	282	21	during	during	IN
cord-302082-aaokc182	282	22	pregnancy	pregnancy	NN
cord-302082-aaokc182	282	23	.	.	.
cord-302082-aaokc182	283	1	Many	many	JJ
cord-302082-aaokc182	283	2	public	public	JJ
cord-302082-aaokc182	283	3	health	health	NN
cord-302082-aaokc182	283	4	authorities	authority	NNS
cord-302082-aaokc182	283	5	worldwide	worldwide	RB
cord-302082-aaokc182	283	6	recommend	recommend	VBP
cord-302082-aaokc182	283	7	seasonal	seasonal	JJ
cord-302082-aaokc182	283	8	influenza	influenza	NN
cord-302082-aaokc182	283	9	vaccination	vaccination	NN
cord-302082-aaokc182	283	10	in	in	IN
cord-302082-aaokc182	283	11	pregnant	pregnant	JJ
cord-302082-aaokc182	283	12	women	woman	NNS
cord-302082-aaokc182	283	13	and	and	CC
cord-302082-aaokc182	283	14	this	this	DT
cord-302082-aaokc182	283	15	recommendation	recommendation	NN
cord-302082-aaokc182	283	16	is	be	VBZ
cord-302082-aaokc182	283	17	motivated	motivate	VBN
cord-302082-aaokc182	283	18	not	not	RB
cord-302082-aaokc182	283	19	only	only	RB
cord-302082-aaokc182	283	20	by	by	IN
cord-302082-aaokc182	283	21	the	the	DT
cord-302082-aaokc182	283	22	potentially	potentially	RB
cord-302082-aaokc182	283	23	severe	severe	JJ
cord-302082-aaokc182	283	24	course	course	NN
cord-302082-aaokc182	283	25	of	of	IN
cord-302082-aaokc182	283	26	influenza	influenza	NN
cord-302082-aaokc182	283	27	during	during	IN
cord-302082-aaokc182	283	28	pregnancy	pregnancy	NN
cord-302082-aaokc182	283	29	,	,	,
cord-302082-aaokc182	283	30	but	but	CC
cord-302082-aaokc182	283	31	also	also	RB
cord-302082-aaokc182	283	32	by	by	IN
cord-302082-aaokc182	283	33	the	the	DT
cord-302082-aaokc182	283	34	need	need	NN
cord-302082-aaokc182	283	35	to	to	TO
cord-302082-aaokc182	283	36	protect	protect	VB
cord-302082-aaokc182	283	37	vulnerable	vulnerable	JJ
cord-302082-aaokc182	283	38	infants	infant	NNS
cord-302082-aaokc182	283	39	against	against	IN
cord-302082-aaokc182	283	40	influenza	influenza	NN
cord-302082-aaokc182	283	41	during	during	IN
cord-302082-aaokc182	283	42	their	-PRON-	PRP$
cord-302082-aaokc182	283	43	first	first	JJ
cord-302082-aaokc182	283	44	months	month	NNS
cord-302082-aaokc182	283	45	of	of	IN
cord-302082-aaokc182	283	46	life	life	NN
cord-302082-aaokc182	283	47	.	.	.
cord-302082-aaokc182	284	1	Boosting	boost	VBG
cord-302082-aaokc182	284	2	RSV	RSV	NNP
cord-302082-aaokc182	284	3	immunity	immunity	NN
cord-302082-aaokc182	284	4	in	in	IN
cord-302082-aaokc182	284	5	pregnant	pregnant	JJ
cord-302082-aaokc182	284	6	women	woman	NNS
cord-302082-aaokc182	284	7	through	through	IN
cord-302082-aaokc182	284	8	vaccination	vaccination	NN
cord-302082-aaokc182	284	9	may	may	MD
cord-302082-aaokc182	284	10	be	be	VB
cord-302082-aaokc182	284	11	another	another	DT
cord-302082-aaokc182	284	12	approach	approach	NN
cord-302082-aaokc182	284	13	to	to	IN
cord-302082-aaokc182	284	14	protecting	protect	VBG
cord-302082-aaokc182	284	15	the	the	DT
cord-302082-aaokc182	284	16	newborn	newborn	NN
cord-302082-aaokc182	284	17	against	against	IN
cord-302082-aaokc182	284	18	RSV	RSV	NNP
cord-302082-aaokc182	284	19	infection	infection	NN
cord-302082-aaokc182	284	20	during	during	IN
cord-302082-aaokc182	284	21	the	the	DT
cord-302082-aaokc182	284	22	most	most	RBS
cord-302082-aaokc182	284	23	vulnerable	vulnerable	JJ
cord-302082-aaokc182	284	24	early	early	JJ
cord-302082-aaokc182	284	25	months	month	NNS
cord-302082-aaokc182	284	26	after	after	IN
cord-302082-aaokc182	284	27	birth	birth	NN
cord-302082-aaokc182	284	28	.	.	.
cord-302082-aaokc182	285	1	Neonatal	neonatal	JJ
cord-302082-aaokc182	285	2	immunisation	immunisation	NN
cord-302082-aaokc182	285	3	is	be	VBZ
cord-302082-aaokc182	285	4	a	a	DT
cord-302082-aaokc182	285	5	strategy	strategy	NN
cord-302082-aaokc182	285	6	to	to	TO
cord-302082-aaokc182	285	7	protect	protect	VB
cord-302082-aaokc182	285	8	infants	infant	NNS
cord-302082-aaokc182	285	9	against	against	IN
cord-302082-aaokc182	285	10	infections	infection	NNS
cord-302082-aaokc182	285	11	during	during	IN
cord-302082-aaokc182	285	12	a	a	DT
cord-302082-aaokc182	285	13	particularly	particularly	RB
cord-302082-aaokc182	285	14	vulnerable	vulnerable	JJ
cord-302082-aaokc182	285	15	period	period	NN
cord-302082-aaokc182	285	16	.	.	.
cord-302082-aaokc182	286	1	A	a	DT
cord-302082-aaokc182	286	2	recent	recent	JJ
cord-302082-aaokc182	286	3	study	study	NN
cord-302082-aaokc182	286	4	showed	show	VBD
cord-302082-aaokc182	286	5	that	that	IN
cord-302082-aaokc182	286	6	immunisation	immunisation	NN
cord-302082-aaokc182	286	7	with	with	IN
cord-302082-aaokc182	286	8	an	an	DT
cord-302082-aaokc182	286	9	acellular	acellular	JJ
cord-302082-aaokc182	286	10	pertussis	pertussis	NN
cord-302082-aaokc182	286	11	vaccine	vaccine	NN
cord-302082-aaokc182	286	12	at	at	IN
cord-302082-aaokc182	286	13	birth	birth	NN
cord-302082-aaokc182	286	14	and	and	CC
cord-302082-aaokc182	286	15	1	1	CD
cord-302082-aaokc182	286	16	month	month	NN
cord-302082-aaokc182	286	17	of	of	IN
cord-302082-aaokc182	286	18	age	age	NN
cord-302082-aaokc182	286	19	induces	induce	VBZ
cord-302082-aaokc182	286	20	high	high	JJ
cord-302082-aaokc182	286	21	IgG	igg	NN
cord-302082-aaokc182	286	22	anti	anti	JJ
cord-302082-aaokc182	286	23	-	-	JJ
cord-302082-aaokc182	286	24	pertussis	pertussis	JJ
cord-302082-aaokc182	286	25	antibody	antibody	NN
cord-302082-aaokc182	286	26	titres	titre	NNS
cord-302082-aaokc182	286	27	by	by	IN
cord-302082-aaokc182	286	28	2	2	CD
cord-302082-aaokc182	286	29	months	month	NNS
cord-302082-aaokc182	286	30	of	of	IN
cord-302082-aaokc182	286	31	age	age	NN
cord-302082-aaokc182	286	32	(	(	-LRB-
cord-302082-aaokc182	286	33	Wood	Wood	NNP
cord-302082-aaokc182	286	34	et	et	FW
cord-302082-aaokc182	286	35	al	al	NNP
cord-302082-aaokc182	286	36	.	.	NNP
cord-302082-aaokc182	286	37	,	,	,
cord-302082-aaokc182	286	38	2010	2010	CD
cord-302082-aaokc182	286	39	)	)	-RRB-
cord-302082-aaokc182	286	40	.	.	.
cord-302082-aaokc182	287	1	It	-PRON-	PRP
cord-302082-aaokc182	287	2	is	be	VBZ
cord-302082-aaokc182	287	3	hoped	hope	VBN
cord-302082-aaokc182	287	4	that	that	IN
cord-302082-aaokc182	287	5	this	this	DT
cord-302082-aaokc182	287	6	approach	approach	NN
cord-302082-aaokc182	287	7	may	may	MD
cord-302082-aaokc182	287	8	reduce	reduce	VB
cord-302082-aaokc182	287	9	death	death	NN
cord-302082-aaokc182	287	10	and	and	CC
cord-302082-aaokc182	287	11	morbidity	morbidity	NN
cord-302082-aaokc182	287	12	from	from	IN
cord-302082-aaokc182	287	13	Bordetella	Bordetella	NNP
cord-302082-aaokc182	287	14	pertussis	pertussis	NN
cord-302082-aaokc182	287	15	infection	infection	NN
cord-302082-aaokc182	287	16	in	in	IN
cord-302082-aaokc182	287	17	the	the	DT
cord-302082-aaokc182	287	18	first	first	JJ
cord-302082-aaokc182	287	19	3	3	CD
cord-302082-aaokc182	287	20	months	month	NNS
cord-302082-aaokc182	287	21	of	of	IN
cord-302082-aaokc182	287	22	life	life	NN
cord-302082-aaokc182	287	23	.	.	.
cord-302082-aaokc182	288	1	The	the	DT
cord-302082-aaokc182	288	2	elderly	elderly	JJ
cord-302082-aaokc182	288	3	respond	respond	VBP
cord-302082-aaokc182	288	4	poorly	poorly	RB
cord-302082-aaokc182	288	5	to	to	IN
cord-302082-aaokc182	288	6	vaccination	vaccination	NN
cord-302082-aaokc182	288	7	as	as	IN
cord-302082-aaokc182	288	8	the	the	DT
cord-302082-aaokc182	288	9	immune	immune	JJ
cord-302082-aaokc182	288	10	system	system	NN
cord-302082-aaokc182	288	11	becomes	become	VBZ
cord-302082-aaokc182	288	12	more	more	RBR
cord-302082-aaokc182	288	13	senescent	senescent	JJ
cord-302082-aaokc182	288	14	with	with	IN
cord-302082-aaokc182	288	15	increasing	increase	VBG
cord-302082-aaokc182	288	16	age	age	NN
cord-302082-aaokc182	288	17	and	and	CC
cord-302082-aaokc182	288	18	,	,	,
cord-302082-aaokc182	288	19	therefore	therefore	RB
cord-302082-aaokc182	288	20	,	,	,
cord-302082-aaokc182	288	21	new	new	JJ
cord-302082-aaokc182	288	22	vaccine	vaccine	NN
cord-302082-aaokc182	288	23	technologies	technology	NNS
cord-302082-aaokc182	288	24	are	be	VBP
cord-302082-aaokc182	288	25	needed	need	VBN
cord-302082-aaokc182	288	26	to	to	TO
cord-302082-aaokc182	288	27	improve	improve	VB
cord-302082-aaokc182	288	28	the	the	DT
cord-302082-aaokc182	288	29	response	response	NN
cord-302082-aaokc182	288	30	to	to	IN
cord-302082-aaokc182	288	31	vaccination	vaccination	NN
cord-302082-aaokc182	288	32	in	in	IN
cord-302082-aaokc182	288	33	this	this	DT
cord-302082-aaokc182	288	34	population	population	NN
cord-302082-aaokc182	288	35	.	.	.
cord-302082-aaokc182	289	1	In	in	IN
cord-302082-aaokc182	289	2	the	the	DT
cord-302082-aaokc182	289	3	late	late	JJ
cord-302082-aaokc182	289	4	1990s	1990	NNS
cord-302082-aaokc182	289	5	,	,	,
cord-302082-aaokc182	289	6	an	an	DT
cord-302082-aaokc182	289	7	influenza	influenza	NN
cord-302082-aaokc182	289	8	vaccine	vaccine	NN
cord-302082-aaokc182	289	9	adjuvanted	adjuvante	VBN
cord-302082-aaokc182	289	10	with	with	IN
cord-302082-aaokc182	289	11	the	the	DT
cord-302082-aaokc182	289	12	oil	oil	NN
cord-302082-aaokc182	289	13	-	-	HYPH
cord-302082-aaokc182	289	14	in	in	IN
cord-302082-aaokc182	289	15	-	-	HYPH
cord-302082-aaokc182	289	16	water	water	NN
cord-302082-aaokc182	289	17	emulsion	emulsion	NN
cord-302082-aaokc182	289	18	,	,	,
cord-302082-aaokc182	289	19	MF59Ô	mf59ô	NN
cord-302082-aaokc182	289	20	,	,	,
cord-302082-aaokc182	289	21	was	be	VBD
cord-302082-aaokc182	289	22	shown	show	VBN
cord-302082-aaokc182	289	23	to	to	TO
cord-302082-aaokc182	289	24	be	be	VB
cord-302082-aaokc182	289	25	more	more	RBR
cord-302082-aaokc182	289	26	effective	effective	JJ
cord-302082-aaokc182	289	27	at	at	IN
cord-302082-aaokc182	289	28	inducing	induce	VBG
cord-302082-aaokc182	289	29	high	high	JJ
cord-302082-aaokc182	289	30	immune	immune	JJ
cord-302082-aaokc182	289	31	responses	response	NNS
cord-302082-aaokc182	289	32	in	in	IN
cord-302082-aaokc182	289	33	the	the	DT
cord-302082-aaokc182	289	34	elderly	elderly	JJ
cord-302082-aaokc182	289	35	(	(	-LRB-
cord-302082-aaokc182	289	36	Minutello	Minutello	NNP
cord-302082-aaokc182	289	37	et	et	NNP
cord-302082-aaokc182	289	38	al	al	NNP
cord-302082-aaokc182	289	39	.	.	NNP
cord-302082-aaokc182	289	40	,	,	,
cord-302082-aaokc182	289	41	1999	1999	CD
cord-302082-aaokc182	289	42	)	)	-RRB-
cord-302082-aaokc182	289	43	.	.	.
cord-302082-aaokc182	290	1	Alternative	alternative	JJ
cord-302082-aaokc182	290	2	vaccine	vaccine	NN
cord-302082-aaokc182	290	3	administration	administration	NN
cord-302082-aaokc182	290	4	techniques	technique	NNS
cord-302082-aaokc182	290	5	have	have	VBP
cord-302082-aaokc182	290	6	also	also	RB
cord-302082-aaokc182	290	7	been	be	VBN
cord-302082-aaokc182	290	8	studied	study	VBN
cord-302082-aaokc182	290	9	in	in	IN
cord-302082-aaokc182	290	10	the	the	DT
cord-302082-aaokc182	290	11	elderly	elderly	JJ
cord-302082-aaokc182	290	12	.	.	.
cord-302082-aaokc182	291	1	Research	research	NN
cord-302082-aaokc182	291	2	showed	show	VBD
cord-302082-aaokc182	291	3	that	that	IN
cord-302082-aaokc182	291	4	in	in	IN
cord-302082-aaokc182	291	5	subjects	subject	NNS
cord-302082-aaokc182	291	6	60	60	CD
cord-302082-aaokc182	291	7	years	year	NNS
cord-302082-aaokc182	291	8	of	of	IN
cord-302082-aaokc182	291	9	age	age	NN
cord-302082-aaokc182	291	10	or	or	CC
cord-302082-aaokc182	291	11	older	old	JJR
cord-302082-aaokc182	291	12	,	,	,
cord-302082-aaokc182	291	13	an	an	DT
cord-302082-aaokc182	291	14	influenza	influenza	NN
cord-302082-aaokc182	291	15	vaccine	vaccine	NN
cord-302082-aaokc182	291	16	administered	administer	VBN
cord-302082-aaokc182	291	17	with	with	IN
cord-302082-aaokc182	291	18	an	an	DT
cord-302082-aaokc182	291	19	intradermal	intradermal	JJ
cord-302082-aaokc182	291	20	microinjection	microinjection	NN
cord-302082-aaokc182	291	21	system	system	NN
cord-302082-aaokc182	291	22	induced	induce	VBN
cord-302082-aaokc182	291	23	significantly	significantly	RB
cord-302082-aaokc182	291	24	higher	high	JJR
cord-302082-aaokc182	291	25	antibody	antibody	NN
cord-302082-aaokc182	291	26	titres	titre	NNS
cord-302082-aaokc182	291	27	compared	compare	VBN
cord-302082-aaokc182	291	28	with	with	IN
cord-302082-aaokc182	291	29	IM	im	JJ
cord-302082-aaokc182	291	30	vaccination	vaccination	NN
cord-302082-aaokc182	291	31	(	(	-LRB-
cord-302082-aaokc182	291	32	Arnou	Arnou	NNP
cord-302082-aaokc182	291	33	et	et	FW
cord-302082-aaokc182	291	34	al	al	NNP
cord-302082-aaokc182	291	35	.	.	NNP
cord-302082-aaokc182	291	36	,	,	,
cord-302082-aaokc182	291	37	2009	2009	CD
cord-302082-aaokc182	291	38	)	)	-RRB-
cord-302082-aaokc182	291	39	.	.	.
cord-302082-aaokc182	292	1	Subsequently	subsequently	RB
cord-302082-aaokc182	292	2	,	,	,
cord-302082-aaokc182	292	3	a	a	DT
cord-302082-aaokc182	292	4	microinjection	microinjection	NN
cord-302082-aaokc182	292	5	system	system	NN
cord-302082-aaokc182	292	6	influenza	influenza	NN
cord-302082-aaokc182	292	7	vaccine	vaccine	NN
cord-302082-aaokc182	292	8	was	be	VBD
cord-302082-aaokc182	292	9	licensed	license	VBN
cord-302082-aaokc182	292	10	for	for	IN
cord-302082-aaokc182	292	11	use	use	NN
cord-302082-aaokc182	292	12	in	in	IN
cord-302082-aaokc182	292	13	Europe	Europe	NNP
cord-302082-aaokc182	292	14	,	,	,
cord-302082-aaokc182	292	15	and	and	CC
cord-302082-aaokc182	292	16	a	a	DT
cord-302082-aaokc182	292	17	high	high	JJ
cord-302082-aaokc182	292	18	antigen	antigen	NN
cord-302082-aaokc182	292	19	dose	dose	NN
cord-302082-aaokc182	292	20	formulation	formulation	NN
cord-302082-aaokc182	292	21	has	have	VBZ
cord-302082-aaokc182	292	22	been	be	VBN
cord-302082-aaokc182	292	23	licensed	license	VBN
cord-302082-aaokc182	292	24	for	for	IN
cord-302082-aaokc182	292	25	the	the	DT
cord-302082-aaokc182	292	26	elderly	elderly	JJ
cord-302082-aaokc182	292	27	in	in	IN
cord-302082-aaokc182	292	28	the	the	DT
cord-302082-aaokc182	292	29	USA	USA	NNP
cord-302082-aaokc182	292	30	.	.	.
cord-302082-aaokc182	293	1	Individuals	individual	NNS
cord-302082-aaokc182	293	2	with	with	IN
cord-302082-aaokc182	293	3	cancer	cancer	NN
cord-302082-aaokc182	293	4	,	,	,
cord-302082-aaokc182	293	5	HIV	HIV	NNP
cord-302082-aaokc182	293	6	infection	infection	NN
cord-302082-aaokc182	293	7	or	or	CC
cord-302082-aaokc182	294	1	who	who	WP
cord-302082-aaokc182	294	2	are	be	VBP
cord-302082-aaokc182	294	3	asplenic	asplenic	NNP
cord-302082-aaokc182	294	4	can	can	MD
cord-302082-aaokc182	294	5	be	be	VB
cord-302082-aaokc182	294	6	immunocompromised	immunocompromise	VBN
cord-302082-aaokc182	294	7	as	as	IN
cord-302082-aaokc182	294	8	a	a	DT
cord-302082-aaokc182	294	9	result	result	NN
cord-302082-aaokc182	294	10	of	of	IN
cord-302082-aaokc182	294	11	their	-PRON-	PRP$
cord-302082-aaokc182	294	12	condition	condition	NN
cord-302082-aaokc182	294	13	.	.	.
cord-302082-aaokc182	295	1	Patients	patient	NNS
cord-302082-aaokc182	295	2	can	can	MD
cord-302082-aaokc182	295	3	also	also	RB
cord-302082-aaokc182	295	4	be	be	VB
cord-302082-aaokc182	295	5	immunocompromised	immunocompromise	VBN
cord-302082-aaokc182	295	6	as	as	IN
cord-302082-aaokc182	295	7	a	a	DT
cord-302082-aaokc182	295	8	result	result	NN
cord-302082-aaokc182	295	9	of	of	IN
cord-302082-aaokc182	295	10	therapy	therapy	NN
cord-302082-aaokc182	295	11	,	,	,
cord-302082-aaokc182	295	12	eg	eg	IN
cord-302082-aaokc182	295	13	when	when	WRB
cord-302082-aaokc182	295	14	receiving	receive	VBG
cord-302082-aaokc182	295	15	an	an	DT
cord-302082-aaokc182	295	16	organ	organ	NN
cord-302082-aaokc182	295	17	transplant	transplant	NN
cord-302082-aaokc182	295	18	,	,	,
cord-302082-aaokc182	295	19	radiation	radiation	NN
cord-302082-aaokc182	295	20	therapy	therapy	NN
cord-302082-aaokc182	295	21	or	or	CC
cord-302082-aaokc182	295	22	immunosuppressive	immunosuppressive	JJ
cord-302082-aaokc182	295	23	medication	medication	NN
cord-302082-aaokc182	295	24	.	.	.
cord-302082-aaokc182	296	1	Such	such	JJ
cord-302082-aaokc182	296	2	patients	patient	NNS
cord-302082-aaokc182	296	3	are	be	VBP
cord-302082-aaokc182	296	4	therefore	therefore	RB
cord-302082-aaokc182	296	5	at	at	IN
cord-302082-aaokc182	296	6	an	an	DT
cord-302082-aaokc182	296	7	elevated	elevated	JJ
cord-302082-aaokc182	296	8	risk	risk	NN
cord-302082-aaokc182	296	9	of	of	IN
cord-302082-aaokc182	296	10	infection	infection	NN
cord-302082-aaokc182	296	11	from	from	IN
cord-302082-aaokc182	296	12	pathogens	pathogen	NNS
cord-302082-aaokc182	296	13	such	such	JJ
cord-302082-aaokc182	296	14	as	as	IN
cord-302082-aaokc182	296	15	herpesviruses	herpesviruses	NNP
cord-302082-aaokc182	296	16	(	(	-LRB-
cord-302082-aaokc182	296	17	particularly	particularly	RB
cord-302082-aaokc182	296	18	CMV	CMV	NNP
cord-302082-aaokc182	296	19	and	and	CC
cord-302082-aaokc182	296	20	EpsteineBarr	EpsteineBarr	NNP
cord-302082-aaokc182	296	21	virus	virus	NN
cord-302082-aaokc182	296	22	)	)	-RRB-
cord-302082-aaokc182	296	23	,	,	,
cord-302082-aaokc182	296	24	HBV	HBV	NNP
cord-302082-aaokc182	296	25	,	,	,
cord-302082-aaokc182	296	26	HCV	HCV	NNP
cord-302082-aaokc182	296	27	,	,	,
cord-302082-aaokc182	296	28	pneumocystis	pneumocystis	NN
cord-302082-aaokc182	296	29	and	and	CC
cord-302082-aaokc182	296	30	coinfections	coinfection	NNS
cord-302082-aaokc182	296	31	and	and	CC
cord-302082-aaokc182	296	32	represent	represent	VB
cord-302082-aaokc182	296	33	a	a	DT
cord-302082-aaokc182	296	34	special	special	JJ
cord-302082-aaokc182	296	35	population	population	NN
cord-302082-aaokc182	296	36	regarding	regard	VBG
cord-302082-aaokc182	296	37	immunisation	immunisation	NN
cord-302082-aaokc182	296	38	.	.	.
cord-302082-aaokc182	297	1	Despite	despite	IN
cord-302082-aaokc182	297	2	a	a	DT
cord-302082-aaokc182	297	3	likely	likely	JJ
cord-302082-aaokc182	297	4	reduction	reduction	NN
cord-302082-aaokc182	297	5	in	in	IN
cord-302082-aaokc182	297	6	the	the	DT
cord-302082-aaokc182	297	7	efficacy	efficacy	NN
cord-302082-aaokc182	297	8	of	of	IN
cord-302082-aaokc182	297	9	vaccinations	vaccination	NNS
cord-302082-aaokc182	297	10	in	in	IN
cord-302082-aaokc182	297	11	immunocompromised	immunocompromised	JJ
cord-302082-aaokc182	297	12	individuals	individual	NNS
cord-302082-aaokc182	297	13	,	,	,
cord-302082-aaokc182	297	14	immunisation	immunisation	NN
cord-302082-aaokc182	297	15	remains	remain	VBZ
cord-302082-aaokc182	297	16	a	a	DT
cord-302082-aaokc182	297	17	frequent	frequent	JJ
cord-302082-aaokc182	297	18	recommendation	recommendation	NN
cord-302082-aaokc182	297	19	in	in	IN
cord-302082-aaokc182	297	20	the	the	DT
cord-302082-aaokc182	297	21	hope	hope	NN
cord-302082-aaokc182	297	22	that	that	IN
cord-302082-aaokc182	297	23	at	at	IN
cord-302082-aaokc182	297	24	least	least	JJS
cord-302082-aaokc182	297	25	partial	partial	JJ
cord-302082-aaokc182	297	26	immunity	immunity	NN
cord-302082-aaokc182	297	27	will	will	MD
cord-302082-aaokc182	297	28	be	be	VB
cord-302082-aaokc182	297	29	achieved	achieve	VBN
cord-302082-aaokc182	297	30	.	.	.
cord-302082-aaokc182	298	1	Eliciting	elicit	VBG
cord-302082-aaokc182	298	2	a	a	DT
cord-302082-aaokc182	298	3	response	response	NN
cord-302082-aaokc182	298	4	from	from	IN
cord-302082-aaokc182	298	5	vaccination	vaccination	NN
cord-302082-aaokc182	298	6	in	in	IN
cord-302082-aaokc182	298	7	immunocompromised	immunocompromised	JJ
cord-302082-aaokc182	298	8	patients	patient	NNS
cord-302082-aaokc182	298	9	may	may	MD
cord-302082-aaokc182	298	10	require	require	VB
cord-302082-aaokc182	298	11	an	an	DT
cord-302082-aaokc182	298	12	increase	increase	NN
cord-302082-aaokc182	298	13	in	in	IN
cord-302082-aaokc182	298	14	the	the	DT
cord-302082-aaokc182	298	15	dose	dose	NN
cord-302082-aaokc182	298	16	and/or	and/or	CC
cord-302082-aaokc182	298	17	number	number	NN
cord-302082-aaokc182	298	18	of	of	IN
cord-302082-aaokc182	298	19	doses	dose	NNS
cord-302082-aaokc182	298	20	;	;	,
cord-302082-aaokc182	298	21	altering	alter	VBG
cord-302082-aaokc182	298	22	the	the	DT
cord-302082-aaokc182	298	23	dosing	dosing	NN
cord-302082-aaokc182	298	24	interval	interval	NN
cord-302082-aaokc182	298	25	;	;	:
cord-302082-aaokc182	298	26	selecting	select	VBG
cord-302082-aaokc182	298	27	a	a	DT
cord-302082-aaokc182	298	28	different	different	JJ
cord-302082-aaokc182	298	29	vaccine	vaccine	NN
cord-302082-aaokc182	298	30	formulation	formulation	NN
cord-302082-aaokc182	298	31	;	;	:
cord-302082-aaokc182	298	32	or	or	CC
cord-302082-aaokc182	298	33	administration	administration	NN
cord-302082-aaokc182	298	34	via	via	IN
cord-302082-aaokc182	298	35	an	an	DT
cord-302082-aaokc182	298	36	alternative	alternative	JJ
cord-302082-aaokc182	298	37	route	route	NN
cord-302082-aaokc182	298	38	.	.	.
cord-302082-aaokc182	299	1	Evidence	evidence	NN
cord-302082-aaokc182	299	2	in	in	IN
cord-302082-aaokc182	299	3	this	this	DT
cord-302082-aaokc182	299	4	patient	patient	JJ
cord-302082-aaokc182	299	5	population	population	NN
cord-302082-aaokc182	299	6	is	be	VBZ
cord-302082-aaokc182	299	7	lacking	lack	VBG
cord-302082-aaokc182	299	8	and	and	CC
cord-302082-aaokc182	299	9	guidelines	guideline	NNS
cord-302082-aaokc182	299	10	are	be	VBP
cord-302082-aaokc182	299	11	often	often	RB
cord-302082-aaokc182	299	12	based	base	VBN
cord-302082-aaokc182	299	13	on	on	IN
cord-302082-aaokc182	299	14	theoretical	theoretical	JJ
cord-302082-aaokc182	299	15	assumptions	assumption	NNS
cord-302082-aaokc182	299	16	.	.	.
cord-302082-aaokc182	300	1	Live	live	JJ
cord-302082-aaokc182	300	2	vaccines	vaccine	NNS
cord-302082-aaokc182	300	3	are	be	VBP
cord-302082-aaokc182	300	4	generally	generally	RB
cord-302082-aaokc182	300	5	contraindicated	contraindicate	VBN
cord-302082-aaokc182	300	6	in	in	IN
cord-302082-aaokc182	300	7	immunocompromised	immunocompromised	JJ
cord-302082-aaokc182	300	8	or	or	CC
cord-302082-aaokc182	300	9	immunosuppressed	immunosuppressed	JJ
cord-302082-aaokc182	300	10	individuals	individual	NNS
cord-302082-aaokc182	300	11	due	due	JJ
cord-302082-aaokc182	300	12	to	to	IN
cord-302082-aaokc182	300	13	the	the	DT
cord-302082-aaokc182	300	14	risk	risk	NN
cord-302082-aaokc182	300	15	of	of	IN
cord-302082-aaokc182	300	16	an	an	DT
cord-302082-aaokc182	300	17	active	active	JJ
cord-302082-aaokc182	300	18	and	and	CC
cord-302082-aaokc182	300	19	symptomatic	symptomatic	JJ
cord-302082-aaokc182	300	20	infection	infection	NN
cord-302082-aaokc182	300	21	resulting	result	VBG
cord-302082-aaokc182	300	22	from	from	IN
cord-302082-aaokc182	300	23	the	the	DT
cord-302082-aaokc182	300	24	vaccine	vaccine	NN
cord-302082-aaokc182	300	25	itself	-PRON-	PRP
cord-302082-aaokc182	300	26	(	(	-LRB-
cord-302082-aaokc182	300	27	non	non	JJ
cord-302082-aaokc182	300	28	-	-	JJ
cord-302082-aaokc182	300	29	controlled	controlled	JJ
cord-302082-aaokc182	300	30	replication	replication	NN
cord-302082-aaokc182	300	31	process	process	NN
cord-302082-aaokc182	300	32	)	)	-RRB-
cord-302082-aaokc182	300	33	.	.	.
cord-302082-aaokc182	301	1	Encouragingly	encouragingly	RB
cord-302082-aaokc182	301	2	,	,	,
cord-302082-aaokc182	301	3	vaccine	vaccine	NN
cord-302082-aaokc182	301	4	formulations	formulation	NNS
cord-302082-aaokc182	301	5	with	with	IN
cord-302082-aaokc182	301	6	highly	highly	RB
cord-302082-aaokc182	301	7	purified	purify	VBN
cord-302082-aaokc182	301	8	antigens	antigen	NNS
cord-302082-aaokc182	301	9	and	and	CC
cord-302082-aaokc182	301	10	novel	novel	NN
cord-302082-aaokc182	301	11	adjuvants	adjuvant	NNS
cord-302082-aaokc182	301	12	or	or	CC
cord-302082-aaokc182	301	13	alternative	alternative	JJ
cord-302082-aaokc182	301	14	deliveries	delivery	NNS
cord-302082-aaokc182	301	15	have	have	VBP
cord-302082-aaokc182	301	16	been	be	VBN
cord-302082-aaokc182	301	17	shown	show	VBN
cord-302082-aaokc182	301	18	to	to	TO
cord-302082-aaokc182	301	19	induce	induce	VB
cord-302082-aaokc182	301	20	more	more	RBR
cord-302082-aaokc182	301	21	effective	effective	JJ
cord-302082-aaokc182	301	22	immune	immune	JJ
cord-302082-aaokc182	301	23	responses	response	NNS
cord-302082-aaokc182	301	24	than	than	IN
cord-302082-aaokc182	301	25	the	the	DT
cord-302082-aaokc182	301	26	classical	classical	JJ
cord-302082-aaokc182	301	27	inactivated	inactivate	VBN
cord-302082-aaokc182	301	28	vaccines	vaccine	NNS
cord-302082-aaokc182	301	29	in	in	IN
cord-302082-aaokc182	301	30	immunocompromised	immunocompromised	JJ
cord-302082-aaokc182	301	31	hosts	host	NNS
cord-302082-aaokc182	301	32	,	,	,
cord-302082-aaokc182	301	33	including	include	VBG
cord-302082-aaokc182	301	34	patients	patient	NNS
cord-302082-aaokc182	301	35	with	with	IN
cord-302082-aaokc182	301	36	end	end	NN
cord-302082-aaokc182	301	37	-	-	HYPH
cord-302082-aaokc182	301	38	stage	stage	NN
cord-302082-aaokc182	301	39	renal	renal	JJ
cord-302082-aaokc182	301	40	diseases	disease	NNS
cord-302082-aaokc182	301	41	in	in	IN
cord-302082-aaokc182	301	42	pre	pre	JJ
cord-302082-aaokc182	301	43	-	-	JJ
cord-302082-aaokc182	301	44	haemodialysis	haemodialysis	JJ
cord-302082-aaokc182	301	45	and	and	CC
cord-302082-aaokc182	301	46	haemodialysis	haemodialysis	NNP
cord-302082-aaokc182	301	47	(	(	-LRB-
cord-302082-aaokc182	301	48	see	see	VB
cord-302082-aaokc182	301	49	Chapter	chapter	NN
cord-302082-aaokc182	301	50	4	4	CD
cord-302082-aaokc182	301	51	e	e	NN
cord-302082-aaokc182	301	52	Vaccine	Vaccine	NNP
cord-302082-aaokc182	301	53	Adjuvants	Adjuvants	NNP
cord-302082-aaokc182	301	54	)	)	-RRB-
cord-302082-aaokc182	301	55	,	,	,
cord-302082-aaokc182	301	56	patients	patient	NNS
cord-302082-aaokc182	301	57	with	with	IN
cord-302082-aaokc182	301	58	HIV	HIV	NNP
cord-302082-aaokc182	301	59	and	and	CC
cord-302082-aaokc182	301	60	those	those	DT
cord-302082-aaokc182	301	61	who	who	WP
cord-302082-aaokc182	301	62	have	have	VBP
cord-302082-aaokc182	301	63	received	receive	VBN
cord-302082-aaokc182	301	64	haematological	haematological	JJ
cord-302082-aaokc182	301	65	stem	stem	NN
cord-302082-aaokc182	301	66	cell	cell	NN
cord-302082-aaokc182	301	67	transplants	transplant	NNS
cord-302082-aaokc182	301	68	.	.	.
cord-302082-aaokc182	302	1	The	the	DT
cord-302082-aaokc182	302	2	future	future	NN
cord-302082-aaokc182	302	3	of	of	IN
cord-302082-aaokc182	302	4	vaccine	vaccine	NN
cord-302082-aaokc182	302	5	development	development	NN
cord-302082-aaokc182	302	6	can	can	MD
cord-302082-aaokc182	302	7	build	build	VB
cord-302082-aaokc182	302	8	on	on	IN
cord-302082-aaokc182	302	9	the	the	DT
cord-302082-aaokc182	302	10	knowledge	knowledge	NN
cord-302082-aaokc182	302	11	and	and	CC
cord-302082-aaokc182	302	12	experience	experience	NN
cord-302082-aaokc182	302	13	gained	gain	VBD
cord-302082-aaokc182	302	14	over	over	IN
cord-302082-aaokc182	302	15	the	the	DT
cord-302082-aaokc182	302	16	last	last	JJ
cord-302082-aaokc182	302	17	200	200	CD
cord-302082-aaokc182	302	18	years	year	NNS
cord-302082-aaokc182	302	19	,	,	,
cord-302082-aaokc182	302	20	and	and	CC
cord-302082-aaokc182	302	21	at	at	IN
cord-302082-aaokc182	302	22	the	the	DT
cord-302082-aaokc182	302	23	same	same	JJ
cord-302082-aaokc182	302	24	time	time	NN
cord-302082-aaokc182	302	25	can	can	MD
cord-302082-aaokc182	302	26	take	take	VB
cord-302082-aaokc182	302	27	advantage	advantage	NN
cord-302082-aaokc182	302	28	of	of	IN
cord-302082-aaokc182	302	29	the	the	DT
cord-302082-aaokc182	302	30	most	most	RBS
cord-302082-aaokc182	302	31	cutting	cutting	JJ
cord-302082-aaokc182	302	32	-	-	HYPH
cord-302082-aaokc182	302	33	edge	edge	NN
cord-302082-aaokc182	302	34	technologies	technology	NNS
cord-302082-aaokc182	302	35	and	and	CC
cord-302082-aaokc182	302	36	194	194	CD
cord-302082-aaokc182	302	37	UNDERSTANDING	understand	VBG
cord-302082-aaokc182	302	38	MODERN	modern	JJ
cord-302082-aaokc182	302	39	VACCINES	vaccine	NNS
cord-302082-aaokc182	302	40	research	research	NN
cord-302082-aaokc182	302	41	.	.	.
cord-302082-aaokc182	303	1	New	new	JJ
cord-302082-aaokc182	303	2	approaches	approach	NNS
cord-302082-aaokc182	303	3	to	to	IN
cord-302082-aaokc182	303	4	antigen	antigen	NN
cord-302082-aaokc182	303	5	selection	selection	NN
cord-302082-aaokc182	303	6	and	and	CC
cord-302082-aaokc182	303	7	production	production	NN
cord-302082-aaokc182	303	8	,	,	,
cord-302082-aaokc182	304	1	antigen	antigen	NNP
cord-302082-aaokc182	304	2	delivery	delivery	NN
cord-302082-aaokc182	304	3	,	,	,
cord-302082-aaokc182	304	4	adjuvantation	adjuvantation	NN
cord-302082-aaokc182	304	5	and	and	CC
cord-302082-aaokc182	304	6	vaccine	vaccine	NN
cord-302082-aaokc182	304	7	administration	administration	NN
cord-302082-aaokc182	304	8	will	will	MD
cord-302082-aaokc182	304	9	allow	allow	VB
cord-302082-aaokc182	304	10	us	-PRON-	PRP
cord-302082-aaokc182	304	11	to	to	TO
cord-302082-aaokc182	304	12	target	target	VB
cord-302082-aaokc182	304	13	established	establish	VBN
cord-302082-aaokc182	304	14	and	and	CC
cord-302082-aaokc182	304	15	emerging	emerge	VBG
cord-302082-aaokc182	304	16	diseases	disease	NNS
cord-302082-aaokc182	304	17	,	,	,
cord-302082-aaokc182	304	18	and	and	CC
cord-302082-aaokc182	304	19	populations	population	NNS
cord-302082-aaokc182	304	20	with	with	IN
cord-302082-aaokc182	304	21	complex	complex	JJ
cord-302082-aaokc182	304	22	needs	need	NNS
cord-302082-aaokc182	304	23	.	.	.
cord-302082-aaokc182	305	1	Vaccination	vaccination	NN
cord-302082-aaokc182	305	2	has	have	VBZ
cord-302082-aaokc182	305	3	been	be	VBN
cord-302082-aaokc182	305	4	one	one	CD
cord-302082-aaokc182	305	5	of	of	IN
cord-302082-aaokc182	305	6	the	the	DT
cord-302082-aaokc182	305	7	most	most	RBS
cord-302082-aaokc182	305	8	successful	successful	JJ
cord-302082-aaokc182	305	9	and	and	CC
cord-302082-aaokc182	305	10	cost	cost	NN
cord-302082-aaokc182	305	11	-	-	HYPH
cord-302082-aaokc182	305	12	effective	effective	JJ
cord-302082-aaokc182	305	13	health	health	NN
cord-302082-aaokc182	305	14	interventions	intervention	NNS
cord-302082-aaokc182	305	15	ever	ever	RB
cord-302082-aaokc182	305	16	conceived	conceive	VBN
cord-302082-aaokc182	305	17	and	and	CC
cord-302082-aaokc182	305	18	is	be	VBZ
cord-302082-aaokc182	305	19	now	now	RB
cord-302082-aaokc182	305	20	expanding	expand	VBG
cord-302082-aaokc182	305	21	further	far	RBR
cord-302082-aaokc182	305	22	into	into	IN
cord-302082-aaokc182	305	23	cancer	cancer	NN
cord-302082-aaokc182	305	24	and	and	CC
cord-302082-aaokc182	305	25	chronic	chronic	JJ
cord-302082-aaokc182	305	26	diseases	disease	NNS
cord-302082-aaokc182	305	27	.	.	.
cord-302082-aaokc182	306	1	This	this	DT
cord-302082-aaokc182	306	2	expansion	expansion	NN
cord-302082-aaokc182	306	3	of	of	IN
cord-302082-aaokc182	306	4	scope	scope	NN
cord-302082-aaokc182	306	5	and	and	CC
cord-302082-aaokc182	306	6	the	the	DT
cord-302082-aaokc182	306	7	subsequent	subsequent	JJ
cord-302082-aaokc182	306	8	impact	impact	NN
cord-302082-aaokc182	306	9	on	on	IN
cord-302082-aaokc182	306	10	human	human	JJ
cord-302082-aaokc182	306	11	disease	disease	NN
cord-302082-aaokc182	306	12	is	be	VBZ
cord-302082-aaokc182	306	13	likely	likely	JJ
cord-302082-aaokc182	306	14	to	to	TO
cord-302082-aaokc182	306	15	continue	continue	VB
cord-302082-aaokc182	306	16	into	into	IN
cord-302082-aaokc182	306	17	the	the	DT
cord-302082-aaokc182	306	18	future	future	NN
cord-302082-aaokc182	306	19	in	in	IN
cord-302082-aaokc182	306	20	currently	currently	RB
cord-302082-aaokc182	306	21	unforeseen	unforeseen	JJ
cord-302082-aaokc182	306	22	ways	way	NNS
cord-302082-aaokc182	306	23	,	,	,
cord-302082-aaokc182	306	24	further	further	RB
cord-302082-aaokc182	306	25	increasing	increase	VBG
cord-302082-aaokc182	306	26	the	the	DT
cord-302082-aaokc182	306	27	importance	importance	NN
cord-302082-aaokc182	306	28	of	of	IN
cord-302082-aaokc182	306	29	vaccine	vaccine	NN
cord-302082-aaokc182	306	30	science	science	NN
cord-302082-aaokc182	306	31	and	and	CC
cord-302082-aaokc182	306	32	engineering	engineering	NN
cord-302082-aaokc182	306	33	in	in	IN
cord-302082-aaokc182	306	34	improving	improve	VBG
cord-302082-aaokc182	306	35	human	human	JJ
cord-302082-aaokc182	306	36	health	health	NN
cord-302082-aaokc182	306	37	.	.	.
cord-302082-aaokc182	307	1	Safety	safety	NN
cord-302082-aaokc182	307	2	and	and	CC
cord-302082-aaokc182	307	3	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	307	4	of	of	IN
cord-302082-aaokc182	307	5	RTS	RTS	NNP
cord-302082-aaokc182	307	6	,	,	,
cord-302082-aaokc182	307	7	S	S	NNP
cord-302082-aaokc182	307	8	/	/	SYM
cord-302082-aaokc182	307	9	AS02D	AS02D	NNP
cord-302082-aaokc182	308	1	malaria	malaria	NNP
cord-302082-aaokc182	308	2	vaccine	vaccine	NN
cord-302082-aaokc182	308	3	in	in	IN
cord-302082-aaokc182	308	4	infants	infant	NNS
cord-302082-aaokc182	308	5	Intradermal	Intradermal	NNP
cord-302082-aaokc182	308	6	influenza	influenza	NN
cord-302082-aaokc182	308	7	vaccine	vaccine	NN
cord-302082-aaokc182	308	8	for	for	IN
cord-302082-aaokc182	308	9	older	old	JJR
cord-302082-aaokc182	308	10	adults	adult	NNS
cord-302082-aaokc182	308	11	:	:	:
cord-302082-aaokc182	309	1	a	a	DT
cord-302082-aaokc182	309	2	randomized	randomized	JJ
cord-302082-aaokc182	309	3	controlled	control	VBN
cord-302082-aaokc182	309	4	multicenter	multicenter	JJ
cord-302082-aaokc182	309	5	phase	phase	NN
cord-302082-aaokc182	309	6	III	iii	CD
cord-302082-aaokc182	309	7	study	study	NN
cord-302082-aaokc182	309	8	Efficacy	Efficacy	NNP
cord-302082-aaokc182	309	9	of	of	IN
cord-302082-aaokc182	309	10	RTS	RTS	NNP
cord-302082-aaokc182	309	11	,	,	,
cord-302082-aaokc182	309	12	S	S	NNP
cord-302082-aaokc182	309	13	/	/	SYM
cord-302082-aaokc182	309	14	AS01E	as01e	NN
cord-302082-aaokc182	309	15	vaccine	vaccine	NN
cord-302082-aaokc182	309	16	against	against	IN
cord-302082-aaokc182	309	17	malaria	malaria	NN
cord-302082-aaokc182	309	18	in	in	IN
cord-302082-aaokc182	309	19	children	child	NNS
cord-302082-aaokc182	309	20	5	5	CD
cord-302082-aaokc182	309	21	to	to	TO
cord-302082-aaokc182	309	22	17	17	CD
cord-302082-aaokc182	309	23	months	month	NNS
cord-302082-aaokc182	309	24	of	of	IN
cord-302082-aaokc182	309	25	age	age	NN
cord-302082-aaokc182	309	26	Women	woman	NNS
cord-302082-aaokc182	309	27	receiving	receive	VBG
cord-302082-aaokc182	309	28	Group	Group	NNP
cord-302082-aaokc182	309	29	B	B	NNP
cord-302082-aaokc182	309	30	Streptococcus	Streptococcus	NNP
cord-302082-aaokc182	309	31	serotype	serotype	NN
cord-302082-aaokc182	309	32	III	iii	NN
cord-302082-aaokc182	309	33	tetanus	tetanus	NN
cord-302082-aaokc182	309	34	toxoid	toxoid	NN
cord-302082-aaokc182	310	1	(	(	-LRB-
cord-302082-aaokc182	310	2	GBS	GBS	NNP
cord-302082-aaokc182	310	3	III	III	NNP
cord-302082-aaokc182	310	4	-	-	HYPH
cord-302082-aaokc182	310	5	TT	TT	NNP
cord-302082-aaokc182	310	6	)	)	-RRB-
cord-302082-aaokc182	310	7	vaccine	vaccine	NN
cord-302082-aaokc182	310	8	have	have	VBP
cord-302082-aaokc182	310	9	reduced	reduce	VBN
cord-302082-aaokc182	310	10	vaginal	vaginal	JJ
cord-302082-aaokc182	310	11	and	and	CC
cord-302082-aaokc182	310	12	rectal	rectal	JJ
cord-302082-aaokc182	310	13	acquisition	acquisition	NN
cord-302082-aaokc182	310	14	of	of	IN
cord-302082-aaokc182	310	15	GBS	GBS	NNP
cord-302082-aaokc182	310	16	Type	Type	NNP
cord-302082-aaokc182	310	17	III	III	NNP
cord-302082-aaokc182	310	18	New	new	JJ
cord-302082-aaokc182	310	19	vaccines	vaccine	NNS
cord-302082-aaokc182	310	20	against	against	IN
cord-302082-aaokc182	310	21	tuberculosis	tuberculosis	NN
cord-302082-aaokc182	310	22	Safety	safety	NN
cord-302082-aaokc182	310	23	and	and	CC
cord-302082-aaokc182	310	24	immunogenicity	immunogenicity	NN
cord-302082-aaokc182	310	25	of	of	IN
cord-302082-aaokc182	310	26	an	an	DT
cord-302082-aaokc182	310	27	inactivated	inactivate	VBN
cord-302082-aaokc182	310	28	subunit	subunit	NN
cord-302082-aaokc182	310	29	influenza	influenza	NN
cord-302082-aaokc182	310	30	virus	virus	NN
cord-302082-aaokc182	310	31	vaccine	vaccine	NN
cord-302082-aaokc182	310	32	combined	combine	VBN
cord-302082-aaokc182	310	33	with	with	IN
cord-302082-aaokc182	310	34	MF59	MF59	NNP
cord-302082-aaokc182	310	35	adjuvant	adjuvant	NN
cord-302082-aaokc182	310	36	emulsion	emulsion	NN
cord-302082-aaokc182	310	37	in	in	IN
cord-302082-aaokc182	310	38	elderly	elderly	JJ
cord-302082-aaokc182	310	39	subjects	subject	NNS
cord-302082-aaokc182	310	40	,	,	,
cord-302082-aaokc182	310	41	immunized	immunize	VBN
cord-302082-aaokc182	310	42	for	for	IN
cord-302082-aaokc182	310	43	three	three	CD
cord-302082-aaokc182	310	44	consecutive	consecutive	JJ
cord-302082-aaokc182	310	45	influenza	influenza	NN
cord-302082-aaokc182	310	46	seasons	season	NNS
cord-302082-aaokc182	310	47	A	a	DT
cord-302082-aaokc182	310	48	vaccine	vaccine	NN
cord-302082-aaokc182	310	49	to	to	TO
cord-302082-aaokc182	310	50	prevent	prevent	VB
cord-302082-aaokc182	310	51	herpes	herpes	NN
cord-302082-aaokc182	310	52	zoster	zoster	NN
cord-302082-aaokc182	310	53	and	and	CC
cord-302082-aaokc182	310	54	postherpetic	postherpetic	NNP
cord-302082-aaokc182	310	55	neuralgia	neuralgia	NN
cord-302082-aaokc182	310	56	in	in	IN
cord-302082-aaokc182	310	57	older	old	JJR
cord-302082-aaokc182	310	58	adults	adult	NNS
cord-302082-aaokc182	311	1	A	a	DT
cord-302082-aaokc182	311	2	subunit	subunit	NN
cord-302082-aaokc182	311	3	cytomegalovirus	cytomegalovirus	NN
cord-302082-aaokc182	311	4	vaccine	vaccine	NN
cord-302082-aaokc182	311	5	based	base	VBN
cord-302082-aaokc182	311	6	on	on	IN
cord-302082-aaokc182	311	7	recombinant	recombinant	JJ
cord-302082-aaokc182	311	8	envelope	envelope	NN
cord-302082-aaokc182	311	9	glycoprotein	glycoprotein	NN
cord-302082-aaokc182	311	10	B	b	NN
cord-302082-aaokc182	311	11	and	and	CC
cord-302082-aaokc182	311	12	a	a	DT
cord-302082-aaokc182	311	13	new	new	JJ
cord-302082-aaokc182	311	14	adjuvant	adjuvant	JJ
cord-302082-aaokc182	311	15	Vaccine	vaccine	NN
cord-302082-aaokc182	311	16	prevention	prevention	NN
cord-302082-aaokc182	311	17	of	of	IN
cord-302082-aaokc182	311	18	maternal	maternal	JJ
cord-302082-aaokc182	311	19	cytomegalovirus	cytomegalovirus	NN
cord-302082-aaokc182	311	20	infection	infection	NN
cord-302082-aaokc182	311	21	Vaccination	Vaccination	NNP
cord-302082-aaokc182	311	22	with	with	IN
cord-302082-aaokc182	311	23	ALVAC	ALVAC	NNP
cord-302082-aaokc182	311	24	and	and	CC
cord-302082-aaokc182	311	25	AIDSVAX	AIDSVAX	NNP
cord-302082-aaokc182	311	26	to	to	TO
cord-302082-aaokc182	311	27	prevent	prevent	VB
cord-302082-aaokc182	311	28	HIV-1	HIV-1	NNP
cord-302082-aaokc182	311	29	infection	infection	NN
cord-302082-aaokc182	311	30	in	in	IN
cord-302082-aaokc182	311	31	Thailand	Thailand	NNP
cord-302082-aaokc182	311	32	Successful	successful	JJ
cord-302082-aaokc182	311	33	immunization	immunization	NN
cord-302082-aaokc182	311	34	of	of	IN
cord-302082-aaokc182	311	35	children	child	NNS
cord-302082-aaokc182	311	36	with	with	IN
cord-302082-aaokc182	311	37	and	and	CC
cord-302082-aaokc182	311	38	without	without	IN
cord-302082-aaokc182	311	39	maternal	maternal	JJ
cord-302082-aaokc182	311	40	antibody	antibody	NN
cord-302082-aaokc182	311	41	by	by	IN
cord-302082-aaokc182	311	42	aerosolized	aerosolized	JJ
cord-302082-aaokc182	311	43	measles	measle	NNS
cord-302082-aaokc182	311	44	vaccine	vaccine	NN
cord-302082-aaokc182	311	45	.	.	.
cord-302082-aaokc182	312	1	I.	i.	LS
cord-302082-aaokc182	312	2	Different	different	JJ
cord-302082-aaokc182	312	3	results	result	NNS
cord-302082-aaokc182	312	4	with	with	IN
cord-302082-aaokc182	312	5	undiluted	undiluted	JJ
cord-302082-aaokc182	312	6	human	human	JJ
cord-302082-aaokc182	312	7	diploid	diploid	JJ
cord-302082-aaokc182	312	8	cell	cell	NN
cord-302082-aaokc182	312	9	and	and	CC
cord-302082-aaokc182	312	10	chick	chick	NN
cord-302082-aaokc182	312	11	embryo	embryo	NN
cord-302082-aaokc182	312	12	fibroblast	fibroblast	NN
cord-302082-aaokc182	312	13	vaccines	vaccine	NNS
cord-302082-aaokc182	312	14	Associate	associate	VBP
cord-302082-aaokc182	312	15	Clinical	clinical	JJ
cord-302082-aaokc182	312	16	Professor	Professor	NNP
cord-302082-aaokc182	312	17	of	of	IN
cord-302082-aaokc182	312	18	Medicine	Medicine	NNP
cord-302082-aaokc182	312	19	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-302082-aaokc182	312	20	Herpes	Herpes	NNP
cord-302082-aaokc182	312	21	Vaccine	Vaccine	NNP
cord-302082-aaokc182	312	22	Efficacy	Efficacy	NNP
cord-302082-aaokc182	312	23	Study	Study	NNP
cord-302082-aaokc182	312	24	Group	Group	NNP
cord-302082-aaokc182	312	25	.	.	.
cord-302082-aaokc182	313	1	Glycoprotein	glycoprotein	NN
cord-302082-aaokc182	313	2	-	-	HYPH
cord-302082-aaokc182	313	3	D	d	NN
cord-302082-aaokc182	313	4	-	-	HYPH
cord-302082-aaokc182	313	5	adjuvant	adjuvant	JJ
cord-302082-aaokc182	313	6	vaccine	vaccine	NN
cord-302082-aaokc182	313	7	to	to	TO
cord-302082-aaokc182	313	8	prevent	prevent	VB
cord-302082-aaokc182	313	9	genital	genital	JJ
cord-302082-aaokc182	313	10	herpes	herpes	NN
cord-302082-aaokc182	313	11	Prevention	prevention	NN
cord-302082-aaokc182	313	12	of	of	IN
cord-302082-aaokc182	313	13	tuberculosis	tuberculosis	NN
cord-302082-aaokc182	313	14	in	in	IN
cord-302082-aaokc182	313	15	Bacille	Bacille	NNP
cord-302082-aaokc182	313	16	Calmette	Calmette	NNP
cord-302082-aaokc182	313	17	-	-	HYPH
cord-302082-aaokc182	313	18	Guérin	Guérin	NNP
cord-302082-aaokc182	313	19	-	-	HYPH
cord-302082-aaokc182	313	20	primed	prime	VBN
cord-302082-aaokc182	313	21	,	,	,
cord-302082-aaokc182	313	22	HIV	HIV	NNP
cord-302082-aaokc182	313	23	-	-	HYPH
cord-302082-aaokc182	313	24	infected	infect	VBN
cord-302082-aaokc182	313	25	adults	adult	NNS
cord-302082-aaokc182	313	26	boosted	boost	VBN
cord-302082-aaokc182	313	27	with	with	IN
cord-302082-aaokc182	313	28	an	an	DT
cord-302082-aaokc182	313	29	inactivated	inactivated	JJ
cord-302082-aaokc182	313	30	whole	whole	JJ
cord-302082-aaokc182	313	31	-	-	HYPH
cord-302082-aaokc182	313	32	cell	cell	NN
cord-302082-aaokc182	313	33	mycobacterial	mycobacterial	JJ
cord-302082-aaokc182	313	34	vaccine	vaccine	NN
cord-302082-aaokc182	314	1	The	the	DT
cord-302082-aaokc182	314	2	second	second	JJ
cord-302082-aaokc182	314	3	Geneva	Geneva	NNP
cord-302082-aaokc182	314	4	Consensus	Consensus	NNP
cord-302082-aaokc182	314	5	:	:	:
cord-302082-aaokc182	314	6	recommendations	recommendation	NNS
cord-302082-aaokc182	314	7	for	for	IN
cord-302082-aaokc182	314	8	novel	novel	NN
cord-302082-aaokc182	314	9	live	live	JJ
cord-302082-aaokc182	314	10	TB	TB	NNP
cord-302082-aaokc182	314	11	vaccines	vaccine	NNS
cord-302082-aaokc182	315	1	Acellular	acellular	JJ
cord-302082-aaokc182	315	2	pertussis	pertussis	NN
cord-302082-aaokc182	315	3	vaccine	vaccine	NN
cord-302082-aaokc182	315	4	at	at	IN
cord-302082-aaokc182	315	5	birth	birth	NN
cord-302082-aaokc182	315	6	and	and	CC
cord-302082-aaokc182	315	7	one	one	CD
cord-302082-aaokc182	315	8	month	month	NN
cord-302082-aaokc182	315	9	induces	induce	VBZ
cord-302082-aaokc182	315	10	antibody	antibody	NN
cord-302082-aaokc182	315	11	responses	response	NNS
cord-302082-aaokc182	315	12	by	by	IN
cord-302082-aaokc182	315	13	two	two	CD
cord-302082-aaokc182	315	14	months	month	NNS
cord-302082-aaokc182	315	15	of	of	IN
cord-302082-aaokc182	315	16	age	age	NN
cord-302082-aaokc182	315	17	Genocea	Genocea	NNP
cord-302082-aaokc182	315	18	technology	technology	NN
cord-302082-aaokc182	315	19	Developing	develop	VBG
cord-302082-aaokc182	315	20	cell	cell	NN
cord-302082-aaokc182	315	21	culture	culture	NN
cord-302082-aaokc182	315	22	-	-	HYPH
cord-302082-aaokc182	315	23	derived	derive	VBN
cord-302082-aaokc182	315	24	pandemic	pandemic	NN
cord-302082-aaokc182	315	25	vaccines	vaccine	NNS
cord-302082-aaokc182	315	26	Seeking	seek	VBG
cord-302082-aaokc182	315	27	new	new	JJ
cord-302082-aaokc182	315	28	pathways	pathway	NNS
cord-302082-aaokc182	315	29	for	for	IN
cord-302082-aaokc182	315	30	HIV	HIV	NNP
cord-302082-aaokc182	315	31	vaccine	vaccine	NN
cord-302082-aaokc182	315	32	discovery	discovery	NN
cord-302082-aaokc182	315	33	Infectious	infectious	JJ
cord-302082-aaokc182	315	34	diseases	disease	NNS
cord-302082-aaokc182	315	35	and	and	CC
cord-302082-aaokc182	315	36	global	global	JJ
cord-302082-aaokc182	315	37	cancer	cancer	NN
cord-302082-aaokc182	315	38	control	control	NN
cord-302082-aaokc182	315	39	Intrauterine	intrauterine	JJ
cord-302082-aaokc182	315	40	infection	infection	NN
cord-302082-aaokc182	315	41	and	and	CC
cord-302082-aaokc182	315	42	preterm	preterm	NNS
cord-302082-aaokc182	315	43	delivery	delivery	NN
cord-302082-aaokc182	316	1	The	the	DT
cord-302082-aaokc182	316	2	NIH	NIH	NNP
cord-302082-aaokc182	316	3	human	human	JJ
cord-302082-aaokc182	316	4	microbiome	microbiome	NN
cord-302082-aaokc182	316	5	project	project	NN
cord-302082-aaokc182	316	6	Alliance	Alliance	NNP
cord-302082-aaokc182	316	7	for	for	IN
cord-302082-aaokc182	316	8	Case	Case	NNP
cord-302082-aaokc182	316	9	Studies	Studies	NNP
cord-302082-aaokc182	316	10	for	for	IN
cord-302082-aaokc182	316	11	Global	Global	NNP
cord-302082-aaokc182	316	12	Health	Health	NNP
cord-302082-aaokc182	316	13	.	.	.
cord-302082-aaokc182	317	1	Case	case	NN
cord-302082-aaokc182	317	2	studies	study	NNS
cord-302082-aaokc182	317	3	for	for	IN
cord-302082-aaokc182	317	4	global	global	JJ
cord-302082-aaokc182	317	5	health	health	NN
cord-302082-aaokc182	317	6	:	:	:
cord-302082-aaokc182	317	7	Building	Building	NNP
cord-302082-aaokc182	317	8	relationships	relationship	NNS
cord-302082-aaokc182	317	9	Alliance	Alliance	NNP
cord-302082-aaokc182	317	10	for	for	IN
cord-302082-aaokc182	317	11	Case	Case	NNP
cord-302082-aaokc182	317	12	Studies	Studies	NNP
cord-302082-aaokc182	317	13	International	International	NNP
cord-302082-aaokc182	317	14	AIDS	AIDS	NNP
cord-302082-aaokc182	317	15	Vaccine	Vaccine	NNP
cord-302082-aaokc182	317	16	Initiative	Initiative	NNP
cord-302082-aaokc182	317	17	VACCINES	vaccine	NNS
cord-302082-aaokc182	317	18	OF	of	IN
cord-302082-aaokc182	317	19	THE	the	DT
cord-302082-aaokc182	317	20	FUTURE	FUTURE	NNP
cord-302082-aaokc182	317	21	National	National	NNP
cord-302082-aaokc182	317	22	Institute	Institute	NNP
cord-302082-aaokc182	317	23	of	of	IN
cord-302082-aaokc182	317	24	Allergy	Allergy	NNP
cord-302082-aaokc182	317	25	and	and	CC
cord-302082-aaokc182	317	26	Infectious	Infectious	NNP
cord-302082-aaokc182	317	27	Diseases	Diseases	NNPS
cord-302082-aaokc182	317	28	(	(	-LRB-
cord-302082-aaokc182	317	29	NIAID	NIAID	NNP
cord-302082-aaokc182	317	30	)	)	-RRB-
cord-302082-aaokc182	317	31	.	.	.
cord-302082-aaokc182	318	1	Statement	statement	NN
cord-302082-aaokc182	318	2	:	:	:
cord-302082-aaokc182	319	1	Study	study	NN
cord-302082-aaokc182	319	2	finds	find	VBZ
cord-302082-aaokc182	319	3	genital	genital	JJ
cord-302082-aaokc182	319	4	herpes	herpes	NN
cord-302082-aaokc182	319	5	vaccine	vaccine	NN
cord-302082-aaokc182	319	6	ineffective	ineffective	JJ
cord-302082-aaokc182	319	7	in	in	IN
cord-302082-aaokc182	319	8	women	woman	NNS
cord-302082-aaokc182	319	9	World	World	NNP
cord-302082-aaokc182	319	10	Health	Health	NNP
cord-302082-aaokc182	319	11	Organization	Organization	NNP
cord-302082-aaokc182	319	12	's	's	POS
cord-302082-aaokc182	319	13	Special	Special	NNP
cord-302082-aaokc182	319	14	Programme	Programme	NNP
cord-302082-aaokc182	319	15	for	for	IN
cord-302082-aaokc182	319	16	Research	Research	NNP
cord-302082-aaokc182	319	17	and	and	CC
cord-302082-aaokc182	319	18	Training	Training	NNP
cord-302082-aaokc182	319	19	in	in	IN
cord-302082-aaokc182	320	1	Tropical	tropical	JJ
cord-302082-aaokc182	320	2	Diseases	Diseases	NNPS
cord-302082-aaokc182	320	3	AIDSVAXÔ	AIDSVAXÔ	NNP
cord-302082-aaokc182	320	4	is	be	VBZ
cord-302082-aaokc182	320	5	a	a	DT
cord-302082-aaokc182	320	6	trademark	trademark	NN
cord-302082-aaokc182	320	7	of	of	IN
cord-302082-aaokc182	320	8	Global	Global	NNP
cord-302082-aaokc182	320	9	Solutions	Solutions	NNPS
cord-302082-aaokc182	320	10	for	for	IN
cord-302082-aaokc182	320	11	Infectious	Infectious	NNP
cord-302082-aaokc182	320	12	Diseases	Diseases	NNPS
cord-302082-aaokc182	320	13	Corporation	Corporation	NNP
cord-302082-aaokc182	320	14	;	;	:
cord-302082-aaokc182	320	15	ALVACÔ	ALVACÔ	NNP
cord-302082-aaokc182	320	16	is	be	VBZ
cord-302082-aaokc182	320	17	a	a	DT
cord-302082-aaokc182	320	18	trademark	trademark	NN
cord-302082-aaokc182	320	19	of	of	IN
cord-302082-aaokc182	320	20	Connaught	Connaught	NNP
cord-302082-aaokc182	320	21	Technology	Technology	NNP
cord-302082-aaokc182	320	22	Corporation	Corporation	NNP
cord-302082-aaokc182	321	1	MF59Ô	MF59Ô	NNP
cord-302082-aaokc182	321	2	is	be	VBZ
cord-302082-aaokc182	321	3	a	a	DT
cord-302082-aaokc182	321	4	trademark	trademark	NN
cord-302082-aaokc182	321	5	of	of	IN
cord-302082-aaokc182	321	6	Novartis	Novartis	NNP
cord-302082-aaokc182	321	7	;	;	:
cord-302082-aaokc182	321	8	MontanideÔ	MontanideÔ	NNP
cord-302082-aaokc182	321	9	is	be	VBZ
cord-302082-aaokc182	321	10	a	a	DT
cord-302082-aaokc182	321	11	trademark	trademark	NN
cord-302082-aaokc182	321	12	of	of	IN
cord-302082-aaokc182	321	13	Seppic	Seppic	NNP
cord-302082-aaokc182	321	14	;	;	:
cord-302082-aaokc182	321	15	NanoStatÔ	NanoStatÔ	NNP
cord-302082-aaokc182	321	16	is	be	VBZ
cord-302082-aaokc182	321	17	a	a	DT
cord-302082-aaokc182	321	18	trademark	trademark	NN
cord-302082-aaokc182	321	19	of	of	IN
cord-302082-aaokc182	321	20	NanoBio	NanoBio	NNP
cord-302082-aaokc182	321	21	Corporation	Corporation	NNP
cord-302082-aaokc182	321	22	.	.	.
cord-302082-aaokc182	322	1	For	for	IN
cord-302082-aaokc182	322	2	details	detail	NNS
cord-302082-aaokc182	322	3	of	of	IN
cord-302082-aaokc182	322	4	trademarks	trademark	NNS
cord-302082-aaokc182	322	5	not	not	RB
cord-302082-aaokc182	322	6	listed	list	VBN
cord-302082-aaokc182	322	7	above	above	RB
cord-302082-aaokc182	322	8	please	please	UH
cord-302082-aaokc182	322	9	see	see	VB
cord-302082-aaokc182	322	10	the	the	DT
cord-302082-aaokc182	322	11	manufacturer	manufacturer	NN
cord-302082-aaokc182	322	12	's	's	POS
cord-302082-aaokc182	322	13	website	website	NN
cord-302082-aaokc182	322	14	(	(	-LRB-
cord-302082-aaokc182	322	15	see	see	VB
cord-302082-aaokc182	322	16	section	section	NN
cord-302082-aaokc182	322	17	Internet	internet	NN
cord-302082-aaokc182	322	18	resources	resource	NNS
cord-302082-aaokc182	322	19	)	)	-RRB-
cord-302082-aaokc182	323	1	VACCINES	vaccine	NNS
cord-302082-aaokc182	323	2	OF	of	IN
cord-302082-aaokc182	323	3	THE	the	DT
cord-302082-aaokc182	323	4	FUTURE	future	NN