id	sid	tid	token	lemma	pos
cord-294366-swwz4kzd	1	1	key	key	JJ
cord-294366-swwz4kzd	2	1	:	:	:
cord-294366-swwz4kzd	2	2	cord-294366-swwz4kzd	cord-294366-swwz4kzd	NNS
cord-294366-swwz4kzd	2	3	authors	author	NNS
cord-294366-swwz4kzd	2	4	:	:	:
cord-294366-swwz4kzd	2	5	Bramwell	Bramwell	NNP
cord-294366-swwz4kzd	2	6	,	,	,
cord-294366-swwz4kzd	2	7	Vincent	Vincent	NNP
cord-294366-swwz4kzd	2	8	W.	W.	NNP
cord-294366-swwz4kzd	2	9	;	;	:
cord-294366-swwz4kzd	2	10	Perrie	Perrie	NNP
cord-294366-swwz4kzd	2	11	,	,	,
cord-294366-swwz4kzd	3	1	Yvonne	Yvonne	NNP
cord-294366-swwz4kzd	3	2	title	title	NN
cord-294366-swwz4kzd	3	3	:	:	:
cord-294366-swwz4kzd	3	4	The	the	DT
cord-294366-swwz4kzd	3	5	rational	rational	JJ
cord-294366-swwz4kzd	3	6	design	design	NN
cord-294366-swwz4kzd	3	7	of	of	IN
cord-294366-swwz4kzd	3	8	vaccines	vaccine	NNS
cord-294366-swwz4kzd	3	9	date	date	NN
cord-294366-swwz4kzd	3	10	:	:	:
cord-294366-swwz4kzd	3	11	2005	2005	CD
cord-294366-swwz4kzd	3	12	-	-	SYM
cord-294366-swwz4kzd	3	13	11	11	CD
cord-294366-swwz4kzd	3	14	-	-	SYM
cord-294366-swwz4kzd	3	15	15	15	CD
cord-294366-swwz4kzd	3	16	journal	journal	NN
cord-294366-swwz4kzd	3	17	:	:	:
cord-294366-swwz4kzd	3	18	Drug	drug	NN
cord-294366-swwz4kzd	3	19	Discov	Discov	NNP
cord-294366-swwz4kzd	4	1	Today	today	NN
cord-294366-swwz4kzd	4	2	DOI	DOI	NNP
cord-294366-swwz4kzd	4	3	:	:	:
cord-294366-swwz4kzd	4	4	10.1016	10.1016	CD
cord-294366-swwz4kzd	4	5	/	/	SYM
cord-294366-swwz4kzd	4	6	s1359	s1359	NNP
cord-294366-swwz4kzd	4	7	-	-	HYPH
cord-294366-swwz4kzd	4	8	6446(05)03600	6446(05)03600	NNP
cord-294366-swwz4kzd	4	9	-	-	HYPH
cord-294366-swwz4kzd	4	10	7	7	CD
cord-294366-swwz4kzd	4	11	sha	sha	NNP
cord-294366-swwz4kzd	4	12	:	:	:
cord-294366-swwz4kzd	4	13	d5e96d010d0c08646164d722ab81f2ab64ab94c9	d5e96d010d0c08646164d722ab81f2ab64ab94c9	NNP
cord-294366-swwz4kzd	4	14	doc_id	doc_id	CD
cord-294366-swwz4kzd	4	15	:	:	:
cord-294366-swwz4kzd	4	16	294366	294366	CD
cord-294366-swwz4kzd	4	17	cord_uid	cord_uid	NNS
cord-294366-swwz4kzd	4	18	:	:	:
cord-294366-swwz4kzd	5	1	swwz4kzd	swwz4kzd	NNP
cord-294366-swwz4kzd	6	1	This	this	DT
cord-294366-swwz4kzd	6	2	review	review	NN
cord-294366-swwz4kzd	6	3	provides	provide	VBZ
cord-294366-swwz4kzd	6	4	an	an	DT
cord-294366-swwz4kzd	6	5	insight	insight	NN
cord-294366-swwz4kzd	6	6	into	into	IN
cord-294366-swwz4kzd	6	7	the	the	DT
cord-294366-swwz4kzd	6	8	various	various	JJ
cord-294366-swwz4kzd	6	9	opportunities	opportunity	NNS
cord-294366-swwz4kzd	6	10	for	for	IN
cord-294366-swwz4kzd	6	11	vaccine	vaccine	NN
cord-294366-swwz4kzd	6	12	intervention	intervention	NN
cord-294366-swwz4kzd	6	13	,	,	,
cord-294366-swwz4kzd	6	14	analysis	analysis	NN
cord-294366-swwz4kzd	6	15	of	of	IN
cord-294366-swwz4kzd	6	16	strategies	strategy	NNS
cord-294366-swwz4kzd	6	17	for	for	IN
cord-294366-swwz4kzd	6	18	vaccine	vaccine	NN
cord-294366-swwz4kzd	6	19	development	development	NN
cord-294366-swwz4kzd	6	20	,	,	,
cord-294366-swwz4kzd	6	21	vaccine	vaccine	NN
cord-294366-swwz4kzd	6	22	ability	ability	NN
cord-294366-swwz4kzd	6	23	to	to	TO
cord-294366-swwz4kzd	6	24	modulate	modulate	VB
cord-294366-swwz4kzd	6	25	immune	immune	JJ
cord-294366-swwz4kzd	6	26	responses	response	NNS
cord-294366-swwz4kzd	6	27	and	and	CC
cord-294366-swwz4kzd	6	28	resultant	resultant	JJ
cord-294366-swwz4kzd	6	29	rational	rational	JJ
cord-294366-swwz4kzd	6	30	vaccine	vaccine	NN
cord-294366-swwz4kzd	6	31	design	design	NN
cord-294366-swwz4kzd	6	32	.	.	.
cord-294366-swwz4kzd	7	1	In	in	IN
cord-294366-swwz4kzd	7	2	addition	addition	NN
cord-294366-swwz4kzd	7	3	,	,	,
cord-294366-swwz4kzd	7	4	wider	wide	JJR
cord-294366-swwz4kzd	7	5	aspects	aspect	NNS
cord-294366-swwz4kzd	7	6	are	be	VBP
cord-294366-swwz4kzd	7	7	considered	consider	VBN
cord-294366-swwz4kzd	7	8	,	,	,
cord-294366-swwz4kzd	7	9	such	such	JJ
cord-294366-swwz4kzd	7	10	as	as	IN
cord-294366-swwz4kzd	7	11	biotechnological	biotechnological	JJ
cord-294366-swwz4kzd	7	12	advances	advance	NNS
cord-294366-swwz4kzd	7	13	,	,	,
cord-294366-swwz4kzd	7	14	advances	advance	NNS
cord-294366-swwz4kzd	7	15	in	in	IN
cord-294366-swwz4kzd	7	16	immunological	immunological	JJ
cord-294366-swwz4kzd	7	17	understanding	understanding	NN
cord-294366-swwz4kzd	7	18	and	and	CC
cord-294366-swwz4kzd	7	19	host	host	NN
cord-294366-swwz4kzd	7	20	–	–	:
cord-294366-swwz4kzd	7	21	pathogen	pathogen	NN
cord-294366-swwz4kzd	7	22	interactions	interaction	NNS
cord-294366-swwz4kzd	7	23	.	.	.
cord-294366-swwz4kzd	8	1	The	the	DT
cord-294366-swwz4kzd	8	2	key	key	JJ
cord-294366-swwz4kzd	8	3	question	question	NN
cord-294366-swwz4kzd	8	4	addressed	address	VBN
cord-294366-swwz4kzd	8	5	here	here	RB
cord-294366-swwz4kzd	8	6	is	be	VBZ
cord-294366-swwz4kzd	8	7	,	,	,
cord-294366-swwz4kzd	8	8	with	with	IN
cord-294366-swwz4kzd	8	9	all	all	PDT
cord-294366-swwz4kzd	8	10	our	-PRON-	PRP$
cord-294366-swwz4kzd	8	11	research	research	NN
cord-294366-swwz4kzd	8	12	and	and	CC
cord-294366-swwz4kzd	8	13	understanding	understanding	NN
cord-294366-swwz4kzd	8	14	,	,	,
cord-294366-swwz4kzd	8	15	have	have	VBP
cord-294366-swwz4kzd	8	16	we	-PRON-	PRP
cord-294366-swwz4kzd	8	17	reached	reach	VBN
cord-294366-swwz4kzd	8	18	a	a	DT
cord-294366-swwz4kzd	8	19	new	new	JJ
cord-294366-swwz4kzd	8	20	echelon	echelon	NN
cord-294366-swwz4kzd	8	21	in	in	IN
cord-294366-swwz4kzd	8	22	vaccine	vaccine	NN
cord-294366-swwz4kzd	8	23	development	development	NN
cord-294366-swwz4kzd	8	24	,	,	,
cord-294366-swwz4kzd	8	25	that	that	DT
cord-294366-swwz4kzd	8	26	of	of	IN
cord-294366-swwz4kzd	8	27	rational	rational	JJ
cord-294366-swwz4kzd	8	28	design	design	NN
cord-294366-swwz4kzd	8	29	?	?	.
cord-294366-swwz4kzd	9	1	The	the	DT
cord-294366-swwz4kzd	9	2	goal	goal	NN
cord-294366-swwz4kzd	9	3	of	of	IN
cord-294366-swwz4kzd	9	4	any	any	DT
cord-294366-swwz4kzd	9	5	vaccination	vaccination	NN
cord-294366-swwz4kzd	9	6	is	be	VBZ
cord-294366-swwz4kzd	9	7	the	the	DT
cord-294366-swwz4kzd	9	8	induction	induction	NN
cord-294366-swwz4kzd	9	9	of	of	IN
cord-294366-swwz4kzd	9	10	an	an	DT
cord-294366-swwz4kzd	9	11	appropriate	appropriate	JJ
cord-294366-swwz4kzd	9	12	and	and	CC
cord-294366-swwz4kzd	9	13	effective	effective	JJ
cord-294366-swwz4kzd	9	14	immune	immune	JJ
cord-294366-swwz4kzd	9	15	response	response	NN
cord-294366-swwz4kzd	9	16	,	,	,
cord-294366-swwz4kzd	9	17	but	but	CC
cord-294366-swwz4kzd	9	18	precisely	precisely	RB
cord-294366-swwz4kzd	9	19	what	what	WP
cord-294366-swwz4kzd	9	20	constitutes	constitute	VBZ
cord-294366-swwz4kzd	9	21	an	an	DT
cord-294366-swwz4kzd	9	22	effective	effective	JJ
cord-294366-swwz4kzd	9	23	immune	immune	JJ
cord-294366-swwz4kzd	9	24	response	response	NN
cord-294366-swwz4kzd	9	25	for	for	IN
cord-294366-swwz4kzd	9	26	many	many	JJ
cord-294366-swwz4kzd	9	27	diseases	disease	NNS
cord-294366-swwz4kzd	9	28	is	be	VBZ
cord-294366-swwz4kzd	9	29	still	still	RB
cord-294366-swwz4kzd	9	30	unclear	unclear	JJ
cord-294366-swwz4kzd	9	31	.	.	.
cord-294366-swwz4kzd	10	1	Specific	specific	JJ
cord-294366-swwz4kzd	10	2	levels	level	NNS
cord-294366-swwz4kzd	10	3	of	of	IN
cord-294366-swwz4kzd	10	4	antibody	antibody	NN
cord-294366-swwz4kzd	10	5	are	be	VBP
cord-294366-swwz4kzd	10	6	considered	consider	VBN
cord-294366-swwz4kzd	10	7	protective	protective	JJ
cord-294366-swwz4kzd	10	8	in	in	IN
cord-294366-swwz4kzd	10	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	10	10	efficacy	efficacy	NN
cord-294366-swwz4kzd	10	11	for	for	IN
cord-294366-swwz4kzd	10	12	vaccines	vaccine	NNS
cord-294366-swwz4kzd	10	13	against	against	IN
cord-294366-swwz4kzd	10	14	hepatitis	hepatitis	NN
cord-294366-swwz4kzd	10	15	,	,	,
cord-294366-swwz4kzd	10	16	diphtheria	diphtheria	NN
cord-294366-swwz4kzd	10	17	and	and	CC
cord-294366-swwz4kzd	10	18	tetanus	tetanus	NN
cord-294366-swwz4kzd	10	19	;	;	:
cord-294366-swwz4kzd	10	20	for	for	IN
cord-294366-swwz4kzd	10	21	example	example	NN
cord-294366-swwz4kzd	10	22	,	,	,
cord-294366-swwz4kzd	10	23	anti	anti	JJ
cord-294366-swwz4kzd	10	24	-	-	JJ
cord-294366-swwz4kzd	10	25	hepatitis	hepatitis	JJ
cord-294366-swwz4kzd	10	26	surface	surface	NN
cord-294366-swwz4kzd	10	27	antigen	antigen	NN
cord-294366-swwz4kzd	10	28	antibody	antibody	NN
cord-294366-swwz4kzd	10	29	levels	level	NNS
cord-294366-swwz4kzd	10	30	>	>	XX
cord-294366-swwz4kzd	11	1	10	10	CD
cord-294366-swwz4kzd	11	2	mIU	mIU	NNP
cord-294366-swwz4kzd	11	3	/	/	SYM
cord-294366-swwz4kzd	11	4	ml	ml	NN
cord-294366-swwz4kzd	11	5	,	,	,
cord-294366-swwz4kzd	11	6	anti	anti	JJ
cord-294366-swwz4kzd	11	7	-	-	JJ
cord-294366-swwz4kzd	11	8	diphtheria	diphtheria	JJ
cord-294366-swwz4kzd	11	9	antibody	antibody	NN
cord-294366-swwz4kzd	11	10	levels	level	NNS
cord-294366-swwz4kzd	12	1	>	>	XX
cord-294366-swwz4kzd	13	1	100	100	CD
cord-294366-swwz4kzd	13	2	mIU	mIU	NNP
cord-294366-swwz4kzd	13	3	/	/	SYM
cord-294366-swwz4kzd	13	4	ml	ml	NN
cord-294366-swwz4kzd	13	5	and	and	CC
cord-294366-swwz4kzd	13	6	anti	anti	JJ
cord-294366-swwz4kzd	13	7	-	-	JJ
cord-294366-swwz4kzd	13	8	tetanus	tetanus	JJ
cord-294366-swwz4kzd	13	9	antibody	antibody	NN
cord-294366-swwz4kzd	13	10	levels	level	NNS
cord-294366-swwz4kzd	14	1	>	>	XX
cord-294366-swwz4kzd	15	1	100	100	CD
cord-294366-swwz4kzd	15	2	mIU	mIU	NNP
cord-294366-swwz4kzd	15	3	/	/	SYM
cord-294366-swwz4kzd	15	4	ml	ml	NNS
cord-294366-swwz4kzd	15	5	are	be	VBP
cord-294366-swwz4kzd	15	6	quoted	quote	VBN
cord-294366-swwz4kzd	15	7	as	as	IN
cord-294366-swwz4kzd	15	8	protective	protective	JJ
cord-294366-swwz4kzd	15	9	levels	level	NNS
cord-294366-swwz4kzd	15	10	of	of	IN
cord-294366-swwz4kzd	15	11	antibody	antibody	NN
cord-294366-swwz4kzd	15	12	in	in	IN
cord-294366-swwz4kzd	15	13	humans	human	NNS
cord-294366-swwz4kzd	15	14	[	[	-LRB-
cord-294366-swwz4kzd	15	15	1	1	CD
cord-294366-swwz4kzd	15	16	,	,	,
cord-294366-swwz4kzd	15	17	2	2	CD
cord-294366-swwz4kzd	15	18	]	]	-RRB-
cord-294366-swwz4kzd	15	19	.	.	.
cord-294366-swwz4kzd	16	1	However	however	RB
cord-294366-swwz4kzd	16	2	,	,	,
cord-294366-swwz4kzd	16	3	for	for	IN
cord-294366-swwz4kzd	16	4	many	many	JJ
cord-294366-swwz4kzd	16	5	other	other	JJ
cord-294366-swwz4kzd	16	6	diseases	disease	NNS
cord-294366-swwz4kzd	16	7	,	,	,
cord-294366-swwz4kzd	16	8	correlations	correlation	NNS
cord-294366-swwz4kzd	16	9	of	of	IN
cord-294366-swwz4kzd	16	10	efficacy	efficacy	NN
cord-294366-swwz4kzd	16	11	are	be	VBP
cord-294366-swwz4kzd	16	12	less	less	RBR
cord-294366-swwz4kzd	16	13	obvious	obvious	JJ
cord-294366-swwz4kzd	16	14	or	or	CC
cord-294366-swwz4kzd	16	15	yet	yet	RB
cord-294366-swwz4kzd	16	16	to	to	TO
cord-294366-swwz4kzd	16	17	be	be	VB
cord-294366-swwz4kzd	16	18	agreed	agree	VBN
cord-294366-swwz4kzd	16	19	.	.	.
cord-294366-swwz4kzd	17	1	By	by	IN
cord-294366-swwz4kzd	17	2	definition	definition	NN
cord-294366-swwz4kzd	17	3	of	of	IN
cord-294366-swwz4kzd	17	4	perceived	perceive	VBN
cord-294366-swwz4kzd	17	5	need	need	NN
cord-294366-swwz4kzd	17	6	,	,	,
cord-294366-swwz4kzd	17	7	we	-PRON-	PRP
cord-294366-swwz4kzd	17	8	are	be	VBP
cord-294366-swwz4kzd	17	9	most	most	RBS
cord-294366-swwz4kzd	17	10	acutely	acutely	RB
cord-294366-swwz4kzd	17	11	aware	aware	JJ
cord-294366-swwz4kzd	17	12	of	of	IN
cord-294366-swwz4kzd	17	13	the	the	DT
cord-294366-swwz4kzd	17	14	requirement	requirement	NN
cord-294366-swwz4kzd	17	15	of	of	IN
cord-294366-swwz4kzd	17	16	effective	effective	JJ
cord-294366-swwz4kzd	17	17	vaccines	vaccine	NNS
cord-294366-swwz4kzd	17	18	against	against	IN
cord-294366-swwz4kzd	17	19	infectious	infectious	JJ
cord-294366-swwz4kzd	17	20	agents	agent	NNS
cord-294366-swwz4kzd	17	21	,	,	,
cord-294366-swwz4kzd	17	22	pathogens	pathogen	NNS
cord-294366-swwz4kzd	17	23	ancient	ancient	JJ
cord-294366-swwz4kzd	17	24	,	,	,
cord-294366-swwz4kzd	17	25	re	re	VBN
cord-294366-swwz4kzd	17	26	-	-	VB
cord-294366-swwz4kzd	17	27	emergent	emergent	JJ
cord-294366-swwz4kzd	17	28	and	and	CC
cord-294366-swwz4kzd	17	29	new	new	JJ
cord-294366-swwz4kzd	17	30	,	,	,
cord-294366-swwz4kzd	17	31	yet	yet	CC
cord-294366-swwz4kzd	17	32	the	the	DT
cord-294366-swwz4kzd	17	33	opportunities	opportunity	NNS
cord-294366-swwz4kzd	17	34	for	for	IN
cord-294366-swwz4kzd	17	35	manipulation	manipulation	NN
cord-294366-swwz4kzd	17	36	of	of	IN
cord-294366-swwz4kzd	17	37	immune	immune	JJ
cord-294366-swwz4kzd	17	38	responses	response	NNS
cord-294366-swwz4kzd	17	39	offer	offer	VBP
cord-294366-swwz4kzd	17	40	potential	potential	NN
cord-294366-swwz4kzd	17	41	in	in	IN
cord-294366-swwz4kzd	17	42	the	the	DT
cord-294366-swwz4kzd	17	43	prevention	prevention	NN
cord-294366-swwz4kzd	17	44	and	and	CC
cord-294366-swwz4kzd	17	45	treatment	treatment	NN
cord-294366-swwz4kzd	17	46	of	of	IN
cord-294366-swwz4kzd	17	47	a	a	DT
cord-294366-swwz4kzd	17	48	far	far	RB
cord-294366-swwz4kzd	17	49	larger	large	JJR
cord-294366-swwz4kzd	17	50	diversity	diversity	NN
cord-294366-swwz4kzd	17	51	of	of	IN
cord-294366-swwz4kzd	17	52	diseases	disease	NNS
cord-294366-swwz4kzd	17	53	.	.	.
cord-294366-swwz4kzd	18	1	From	from	IN
cord-294366-swwz4kzd	18	2	these	these	DT
cord-294366-swwz4kzd	18	3	,	,	,
cord-294366-swwz4kzd	18	4	immunomodulation	immunomodulation	NN
cord-294366-swwz4kzd	18	5	in	in	IN
cord-294366-swwz4kzd	18	6	cancer	cancer	NN
cord-294366-swwz4kzd	18	7	,	,	,
cord-294366-swwz4kzd	18	8	allergy	allergy	NN
cord-294366-swwz4kzd	18	9	and	and	CC
cord-294366-swwz4kzd	18	10	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	18	11	disease	disease	NN
cord-294366-swwz4kzd	18	12	are	be	VBP
cord-294366-swwz4kzd	18	13	also	also	RB
cord-294366-swwz4kzd	18	14	considered	consider	VBN
cord-294366-swwz4kzd	18	15	here	here	RB
cord-294366-swwz4kzd	18	16	.	.	.
cord-294366-swwz4kzd	19	1	Recent	recent	JJ
cord-294366-swwz4kzd	19	2	developments	development	NNS
cord-294366-swwz4kzd	19	3	have	have	VBP
cord-294366-swwz4kzd	19	4	brought	bring	VBN
cord-294366-swwz4kzd	19	5	vaccines	vaccine	NNS
cord-294366-swwz4kzd	19	6	against	against	IN
cord-294366-swwz4kzd	19	7	infectious	infectious	JJ
cord-294366-swwz4kzd	19	8	diseases	disease	NNS
cord-294366-swwz4kzd	19	9	to	to	IN
cord-294366-swwz4kzd	19	10	the	the	DT
cord-294366-swwz4kzd	19	11	forefront	forefront	NN
cord-294366-swwz4kzd	19	12	of	of	IN
cord-294366-swwz4kzd	19	13	the	the	DT
cord-294366-swwz4kzd	19	14	scientific	scientific	JJ
cord-294366-swwz4kzd	19	15	community	community	NN
cord-294366-swwz4kzd	19	16	.	.	.
cord-294366-swwz4kzd	20	1	The	the	DT
cord-294366-swwz4kzd	20	2	'	'	``
cord-294366-swwz4kzd	20	3	wake	wake	VBP
cord-294366-swwz4kzd	20	4	up	up	RP
cord-294366-swwz4kzd	20	5	call	call	NN
cord-294366-swwz4kzd	20	6	'	'	''
cord-294366-swwz4kzd	20	7	that	that	WDT
cord-294366-swwz4kzd	20	8	came	come	VBD
cord-294366-swwz4kzd	20	9	from	from	IN
cord-294366-swwz4kzd	20	10	SARS	SARS	NNP
cord-294366-swwz4kzd	20	11	(	(	-LRB-
cord-294366-swwz4kzd	20	12	severe	severe	JJ
cord-294366-swwz4kzd	20	13	acute	acute	JJ
cord-294366-swwz4kzd	20	14	respiratory	respiratory	JJ
cord-294366-swwz4kzd	20	15	syndrome	syndrome	NN
cord-294366-swwz4kzd	20	16	)	)	-RRB-
cord-294366-swwz4kzd	20	17	has	have	VBZ
cord-294366-swwz4kzd	20	18	undoubtedly	undoubtedly	RB
cord-294366-swwz4kzd	20	19	fuelled	fuel	VBN
cord-294366-swwz4kzd	20	20	present	present	JJ
cord-294366-swwz4kzd	20	21	fears	fear	NNS
cord-294366-swwz4kzd	20	22	of	of	IN
cord-294366-swwz4kzd	20	23	a	a	DT
cord-294366-swwz4kzd	20	24	flu	flu	NN
cord-294366-swwz4kzd	20	25	pandemic	pandemic	NN
cord-294366-swwz4kzd	20	26	.	.	.
cord-294366-swwz4kzd	21	1	The	the	DT
cord-294366-swwz4kzd	21	2	1918	1918	CD
cord-294366-swwz4kzd	21	3	Spanish	spanish	JJ
cord-294366-swwz4kzd	21	4	flu	flu	NN
cord-294366-swwz4kzd	21	5	pandemic	pandemic	NN
cord-294366-swwz4kzd	21	6	provides	provide	VBZ
cord-294366-swwz4kzd	21	7	an	an	DT
cord-294366-swwz4kzd	21	8	extreme	extreme	JJ
cord-294366-swwz4kzd	21	9	historical	historical	JJ
cord-294366-swwz4kzd	21	10	precedent	precedent	NN
cord-294366-swwz4kzd	21	11	,	,	,
cord-294366-swwz4kzd	21	12	causing	cause	VBG
cord-294366-swwz4kzd	21	13	an	an	DT
cord-294366-swwz4kzd	21	14	estimated	estimate	VBN
cord-294366-swwz4kzd	21	15	50	50	CD
cord-294366-swwz4kzd	21	16	million	million	CD
cord-294366-swwz4kzd	21	17	deaths	death	NNS
cord-294366-swwz4kzd	21	18	after	after	IN
cord-294366-swwz4kzd	21	19	infecting	infect	VBG
cord-294366-swwz4kzd	21	20	one	one	CD
cord-294366-swwz4kzd	21	21	billion	billion	CD
cord-294366-swwz4kzd	21	22	people	people	NNS
cord-294366-swwz4kzd	21	23	worldwide	worldwide	RB
cord-294366-swwz4kzd	21	24	[	[	-LRB-
cord-294366-swwz4kzd	21	25	3	3	CD
cord-294366-swwz4kzd	21	26	]	]	-RRB-
cord-294366-swwz4kzd	21	27	.	.	.
cord-294366-swwz4kzd	22	1	As	as	IN
cord-294366-swwz4kzd	22	2	to	to	IN
cord-294366-swwz4kzd	22	3	the	the	DT
cord-294366-swwz4kzd	22	4	impact	impact	NN
cord-294366-swwz4kzd	22	5	of	of	IN
cord-294366-swwz4kzd	22	6	such	such	PDT
cord-294366-swwz4kzd	22	7	an	an	DT
cord-294366-swwz4kzd	22	8	outbreak	outbreak	NN
cord-294366-swwz4kzd	22	9	,	,	,
cord-294366-swwz4kzd	22	10	today	today	NN
cord-294366-swwz4kzd	22	11	there	there	EX
cord-294366-swwz4kzd	22	12	is	be	VBZ
cord-294366-swwz4kzd	22	13	serious	serious	JJ
cord-294366-swwz4kzd	22	14	concern	concern	NN
cord-294366-swwz4kzd	22	15	over	over	IN
cord-294366-swwz4kzd	22	16	the	the	DT
cord-294366-swwz4kzd	22	17	capacity	capacity	NN
cord-294366-swwz4kzd	22	18	of	of	IN
cord-294366-swwz4kzd	22	19	the	the	DT
cord-294366-swwz4kzd	22	20	existing	exist	VBG
cord-294366-swwz4kzd	22	21	infrastructure	infrastructure	NN
cord-294366-swwz4kzd	22	22	to	to	TO
cord-294366-swwz4kzd	22	23	limit	limit	VB
cord-294366-swwz4kzd	22	24	fatalities	fatality	NNS
cord-294366-swwz4kzd	22	25	by	by	IN
cord-294366-swwz4kzd	22	26	providing	provide	VBG
cord-294366-swwz4kzd	22	27	suitable	suitable	JJ
cord-294366-swwz4kzd	22	28	healthcare	healthcare	NN
cord-294366-swwz4kzd	22	29	[	[	-LRB-
cord-294366-swwz4kzd	22	30	4	4	CD
cord-294366-swwz4kzd	22	31	]	]	-RRB-
cord-294366-swwz4kzd	22	32	.	.	.
cord-294366-swwz4kzd	23	1	Although	although	IN
cord-294366-swwz4kzd	23	2	development	development	NN
cord-294366-swwz4kzd	23	3	of	of	IN
cord-294366-swwz4kzd	23	4	a	a	DT
cord-294366-swwz4kzd	23	5	suitable	suitable	JJ
cord-294366-swwz4kzd	23	6	vaccine	vaccine	NN
cord-294366-swwz4kzd	23	7	can	can	MD
cord-294366-swwz4kzd	23	8	take	take	VB
cord-294366-swwz4kzd	23	9	a	a	DT
cord-294366-swwz4kzd	23	10	minimum	minimum	NN
cord-294366-swwz4kzd	23	11	of	of	IN
cord-294366-swwz4kzd	23	12	six	six	CD
cord-294366-swwz4kzd	23	13	months	month	NNS
cord-294366-swwz4kzd	23	14	,	,	,
cord-294366-swwz4kzd	23	15	in	in	IN
cord-294366-swwz4kzd	23	16	an	an	DT
cord-294366-swwz4kzd	23	17	organized	organized	JJ
cord-294366-swwz4kzd	23	18	and	and	CC
cord-294366-swwz4kzd	23	19	prepared	prepared	JJ
cord-294366-swwz4kzd	23	20	scenario	scenario	NN
cord-294366-swwz4kzd	23	21	this	this	DT
cord-294366-swwz4kzd	23	22	could	could	MD
cord-294366-swwz4kzd	23	23	provide	provide	VB
cord-294366-swwz4kzd	23	24	the	the	DT
cord-294366-swwz4kzd	23	25	major	major	JJ
cord-294366-swwz4kzd	23	26	weapon	weapon	NN
cord-294366-swwz4kzd	23	27	that	that	WDT
cord-294366-swwz4kzd	23	28	will	will	MD
cord-294366-swwz4kzd	23	29	ultimately	ultimately	RB
cord-294366-swwz4kzd	23	30	contain	contain	VB
cord-294366-swwz4kzd	23	31	such	such	PDT
cord-294366-swwz4kzd	23	32	a	a	DT
cord-294366-swwz4kzd	23	33	catastrophe	catastrophe	NN
cord-294366-swwz4kzd	23	34	.	.	.
cord-294366-swwz4kzd	24	1	The	the	DT
cord-294366-swwz4kzd	24	2	latest	late	JJS
cord-294366-swwz4kzd	24	3	polio	polio	NN
cord-294366-swwz4kzd	24	4	outbreaks	outbreak	NNS
cord-294366-swwz4kzd	24	5	look	look	VBP
cord-294366-swwz4kzd	24	6	set	set	VBN
cord-294366-swwz4kzd	24	7	to	to	TO
cord-294366-swwz4kzd	24	8	delay	delay	VB
cord-294366-swwz4kzd	24	9	the	the	DT
cord-294366-swwz4kzd	24	10	long	long	JJ
cord-294366-swwz4kzd	24	11	hope	hope	NN
cord-294366-swwz4kzd	24	12	for	for	IN
cord-294366-swwz4kzd	24	13	eradication	eradication	NN
cord-294366-swwz4kzd	24	14	of	of	IN
cord-294366-swwz4kzd	24	15	this	this	DT
cord-294366-swwz4kzd	24	16	disease	disease	NN
cord-294366-swwz4kzd	24	17	[	[	-LRB-
cord-294366-swwz4kzd	24	18	5	5	CD
cord-294366-swwz4kzd	24	19	]	]	-RRB-
cord-294366-swwz4kzd	24	20	.	.	.
cord-294366-swwz4kzd	25	1	In	in	IN
cord-294366-swwz4kzd	25	2	the	the	DT
cord-294366-swwz4kzd	25	3	UK	UK	NNP
cord-294366-swwz4kzd	25	4	,	,	,
cord-294366-swwz4kzd	25	5	the	the	DT
cord-294366-swwz4kzd	25	6	substitution	substitution	NN
cord-294366-swwz4kzd	25	7	of	of	IN
cord-294366-swwz4kzd	25	8	the	the	DT
cord-294366-swwz4kzd	25	9	live	live	JJ
cord-294366-swwz4kzd	25	10	oral	oral	JJ
cord-294366-swwz4kzd	25	11	polio	polio	NN
cord-294366-swwz4kzd	25	12	vaccine	vaccine	NN
cord-294366-swwz4kzd	25	13	with	with	IN
cord-294366-swwz4kzd	25	14	an	an	DT
cord-294366-swwz4kzd	25	15	inactive	inactive	JJ
cord-294366-swwz4kzd	25	16	vaccine	vaccine	NN
cord-294366-swwz4kzd	25	17	should	should	MD
cord-294366-swwz4kzd	25	18	provide	provide	VB
cord-294366-swwz4kzd	25	19	a	a	DT
cord-294366-swwz4kzd	25	20	step	step	NN
cord-294366-swwz4kzd	25	21	towards	towards	IN
cord-294366-swwz4kzd	25	22	safe	safe	JJ
cord-294366-swwz4kzd	25	23	cessation	cessation	NN
cord-294366-swwz4kzd	25	24	of	of	IN
cord-294366-swwz4kzd	25	25	polio	polio	NN
cord-294366-swwz4kzd	25	26	vaccination	vaccination	NN
cord-294366-swwz4kzd	25	27	when	when	WRB
cord-294366-swwz4kzd	25	28	the	the	DT
cord-294366-swwz4kzd	25	29	time	time	NN
cord-294366-swwz4kzd	25	30	is	be	VBZ
cord-294366-swwz4kzd	25	31	right	right	JJ
cord-294366-swwz4kzd	25	32	.	.	.
cord-294366-swwz4kzd	26	1	The	the	DT
cord-294366-swwz4kzd	26	2	live	live	JJ
cord-294366-swwz4kzd	26	3	vaccine	vaccine	NN
cord-294366-swwz4kzd	26	4	has	have	VBZ
cord-294366-swwz4kzd	26	5	the	the	DT
cord-294366-swwz4kzd	26	6	capacity	capacity	NN
cord-294366-swwz4kzd	26	7	to	to	TO
cord-294366-swwz4kzd	26	8	generate	generate	VB
cord-294366-swwz4kzd	26	9	infectious	infectious	JJ
cord-294366-swwz4kzd	26	10	polio	polio	NN
cord-294366-swwz4kzd	26	11	virus	virus	NN
cord-294366-swwz4kzd	26	12	through	through	IN
cord-294366-swwz4kzd	26	13	mutation	mutation	NN
cord-294366-swwz4kzd	26	14	,	,	,
cord-294366-swwz4kzd	26	15	and	and	CC
cord-294366-swwz4kzd	26	16	altered	alter	VBN
cord-294366-swwz4kzd	26	17	immunological	immunological	JJ
cord-294366-swwz4kzd	26	18	properties	property	NNS
cord-294366-swwz4kzd	26	19	of	of	IN
cord-294366-swwz4kzd	26	20	mutants	mutant	NNS
cord-294366-swwz4kzd	26	21	present	present	VBP
cord-294366-swwz4kzd	26	22	concern	concern	NN
cord-294366-swwz4kzd	26	23	about	about	IN
cord-294366-swwz4kzd	26	24	virus	virus	NN
cord-294366-swwz4kzd	26	25	spread	spread	VBN
cord-294366-swwz4kzd	26	26	in	in	IN
cord-294366-swwz4kzd	26	27	immunized	immunize	VBN
cord-294366-swwz4kzd	26	28	as	as	RB
cord-294366-swwz4kzd	26	29	well	well	RB
cord-294366-swwz4kzd	26	30	as	as	IN
cord-294366-swwz4kzd	26	31	non	non	JJ
cord-294366-swwz4kzd	26	32	-	-	JJ
cord-294366-swwz4kzd	26	33	immunized	immunize	VBN
cord-294366-swwz4kzd	26	34	populations	population	NNS
cord-294366-swwz4kzd	26	35	[	[	-LRB-
cord-294366-swwz4kzd	26	36	6	6	CD
cord-294366-swwz4kzd	26	37	,	,	,
cord-294366-swwz4kzd	26	38	7	7	CD
cord-294366-swwz4kzd	26	39	]	]	-RRB-
cord-294366-swwz4kzd	26	40	.	.	.
cord-294366-swwz4kzd	27	1	Taken	take	VBN
cord-294366-swwz4kzd	27	2	as	as	IN
cord-294366-swwz4kzd	27	3	a	a	DT
cord-294366-swwz4kzd	27	4	whole	whole	NN
cord-294366-swwz4kzd	27	5	,	,	,
cord-294366-swwz4kzd	27	6	vaccine	vaccine	NN
cord-294366-swwz4kzd	27	7	research	research	NN
cord-294366-swwz4kzd	27	8	and	and	CC
cord-294366-swwz4kzd	27	9	development	development	NN
cord-294366-swwz4kzd	27	10	encompasses	encompass	VBZ
cord-294366-swwz4kzd	27	11	a	a	DT
cord-294366-swwz4kzd	27	12	wide	wide	JJ
cord-294366-swwz4kzd	27	13	diversity	diversity	NN
cord-294366-swwz4kzd	27	14	of	of	IN
cord-294366-swwz4kzd	27	15	potential	potential	JJ
cord-294366-swwz4kzd	27	16	applications	application	NNS
cord-294366-swwz4kzd	27	17	,	,	,
cord-294366-swwz4kzd	27	18	developmental	developmental	JJ
cord-294366-swwz4kzd	27	19	strategies	strategy	NNS
cord-294366-swwz4kzd	27	20	and	and	CC
cord-294366-swwz4kzd	27	21	opportunities	opportunity	NNS
cord-294366-swwz4kzd	27	22	.	.	.
cord-294366-swwz4kzd	28	1	The	the	DT
cord-294366-swwz4kzd	28	2	ongoing	ongoing	JJ
cord-294366-swwz4kzd	28	3	elucidation	elucidation	NN
cord-294366-swwz4kzd	28	4	of	of	IN
cord-294366-swwz4kzd	28	5	immunological	immunological	JJ
cord-294366-swwz4kzd	28	6	mechanisms	mechanism	NNS
cord-294366-swwz4kzd	28	7	of	of	IN
cord-294366-swwz4kzd	28	8	pathogen	pathogen	NN
cord-294366-swwz4kzd	28	9	recognition	recognition	NN
cord-294366-swwz4kzd	28	10	and	and	CC
cord-294366-swwz4kzd	28	11	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	28	12	action	action	NN
cord-294366-swwz4kzd	28	13	,	,	,
cord-294366-swwz4kzd	28	14	as	as	RB
cord-294366-swwz4kzd	28	15	well	well	RB
cord-294366-swwz4kzd	28	16	as	as	IN
cord-294366-swwz4kzd	28	17	the	the	DT
cord-294366-swwz4kzd	28	18	knowledge	knowledge	NN
cord-294366-swwz4kzd	28	19	of	of	IN
cord-294366-swwz4kzd	28	20	pathogen	pathogen	NN
cord-294366-swwz4kzd	28	21	mediated	mediate	VBN
cord-294366-swwz4kzd	28	22	mechanisms	mechanism	NNS
cord-294366-swwz4kzd	28	23	of	of	IN
cord-294366-swwz4kzd	28	24	immune	immune	JJ
cord-294366-swwz4kzd	28	25	evasion	evasion	NN
cord-294366-swwz4kzd	28	26	and	and	CC
cord-294366-swwz4kzd	28	27	gene	gene	NN
cord-294366-swwz4kzd	28	28	expression	expression	NN
cord-294366-swwz4kzd	28	29	,	,	,
cord-294366-swwz4kzd	28	30	have	have	VBP
cord-294366-swwz4kzd	28	31	transformed	transform	VBN
cord-294366-swwz4kzd	28	32	our	-PRON-	PRP$
cord-294366-swwz4kzd	28	33	understanding	understanding	NN
cord-294366-swwz4kzd	28	34	of	of	IN
cord-294366-swwz4kzd	28	35	immunology	immunology	NN
cord-294366-swwz4kzd	28	36	and	and	CC
cord-294366-swwz4kzd	28	37	disease	disease	NN
cord-294366-swwz4kzd	28	38	in	in	IN
cord-294366-swwz4kzd	28	39	recent	recent	JJ
cord-294366-swwz4kzd	28	40	years	year	NNS
cord-294366-swwz4kzd	28	41	.	.	.
cord-294366-swwz4kzd	29	1	In	in	IN
cord-294366-swwz4kzd	29	2	this	this	DT
cord-294366-swwz4kzd	29	3	complex	complex	NN
cord-294366-swwz4kzd	29	4	but	but	CC
cord-294366-swwz4kzd	29	5	increasingly	increasingly	RB
cord-294366-swwz4kzd	29	6	focussed	focusse	VBN
cord-294366-swwz4kzd	29	7	environment	environment	NN
cord-294366-swwz4kzd	29	8	of	of	IN
cord-294366-swwz4kzd	29	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	29	10	development	development	NN
cord-294366-swwz4kzd	29	11	,	,	,
cord-294366-swwz4kzd	29	12	are	be	VBP
cord-294366-swwz4kzd	29	13	there	there	EX
cord-294366-swwz4kzd	29	14	opportunities	opportunity	NNS
cord-294366-swwz4kzd	29	15	for	for	IN
cord-294366-swwz4kzd	29	16	new	new	JJ
cord-294366-swwz4kzd	29	17	solutions	solution	NNS
cord-294366-swwz4kzd	29	18	for	for	IN
cord-294366-swwz4kzd	29	19	vaccine	vaccine	NN
cord-294366-swwz4kzd	29	20	design	design	NN
cord-294366-swwz4kzd	29	21	?	?	.
cord-294366-swwz4kzd	30	1	And	and	CC
cord-294366-swwz4kzd	30	2	can	can	MD
cord-294366-swwz4kzd	30	3	new	new	VB
cord-294366-swwz4kzd	30	4	and	and	CC
cord-294366-swwz4kzd	30	5	refined	refined	JJ
cord-294366-swwz4kzd	30	6	approaches	approach	NNS
cord-294366-swwz4kzd	30	7	succeed	succeed	VBP
cord-294366-swwz4kzd	30	8	where	where	WRB
cord-294366-swwz4kzd	30	9	more	more	JJR
cord-294366-swwz4kzd	30	10	conventional	conventional	JJ
cord-294366-swwz4kzd	30	11	approaches	approach	NNS
cord-294366-swwz4kzd	30	12	appear	appear	VBP
cord-294366-swwz4kzd	30	13	to	to	TO
cord-294366-swwz4kzd	30	14	have	have	VB
cord-294366-swwz4kzd	30	15	failed	fail	VBN
cord-294366-swwz4kzd	30	16	?	?	.
cord-294366-swwz4kzd	31	1	There	there	EX
cord-294366-swwz4kzd	31	2	are	be	VBP
cord-294366-swwz4kzd	31	3	several	several	JJ
cord-294366-swwz4kzd	31	4	reasons	reason	NNS
cord-294366-swwz4kzd	31	5	as	as	IN
cord-294366-swwz4kzd	31	6	to	to	IN
cord-294366-swwz4kzd	31	7	why	why	WRB
cord-294366-swwz4kzd	31	8	the	the	DT
cord-294366-swwz4kzd	31	9	bacillus	bacillus	NN
cord-294366-swwz4kzd	31	10	Calmette	Calmette	NNP
cord-294366-swwz4kzd	31	11	-	-	HYPH
cord-294366-swwz4kzd	31	12	Guérin	Guérin	NNP
cord-294366-swwz4kzd	31	13	(	(	-LRB-
cord-294366-swwz4kzd	31	14	BCG	BCG	NNP
cord-294366-swwz4kzd	31	15	)	)	-RRB-
cord-294366-swwz4kzd	31	16	vaccine	vaccine	NN
cord-294366-swwz4kzd	31	17	against	against	IN
cord-294366-swwz4kzd	31	18	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	31	19	(	(	-LRB-
cord-294366-swwz4kzd	31	20	TB	TB	NNP
cord-294366-swwz4kzd	31	21	)	)	-RRB-
cord-294366-swwz4kzd	31	22	is	be	VBZ
cord-294366-swwz4kzd	31	23	perceived	perceive	VBN
cord-294366-swwz4kzd	31	24	as	as	IN
cord-294366-swwz4kzd	31	25	ineffective	ineffective	JJ
cord-294366-swwz4kzd	31	26	,	,	,
cord-294366-swwz4kzd	31	27	including	include	VBG
cord-294366-swwz4kzd	31	28	manipulation	manipulation	NN
cord-294366-swwz4kzd	31	29	of	of	IN
cord-294366-swwz4kzd	31	30	immune	immune	JJ
cord-294366-swwz4kzd	31	31	responses	response	NNS
cord-294366-swwz4kzd	31	32	(	(	-LRB-
cord-294366-swwz4kzd	31	33	as	as	IN
cord-294366-swwz4kzd	31	34	for	for	IN
cord-294366-swwz4kzd	31	35	virulent	virulent	JJ
cord-294366-swwz4kzd	31	36	TB	TB	NNP
cord-294366-swwz4kzd	31	37	[	[	-LRB-
cord-294366-swwz4kzd	31	38	8	8	CD
cord-294366-swwz4kzd	31	39	,	,	,
cord-294366-swwz4kzd	31	40	9	9	CD
cord-294366-swwz4kzd	31	41	]	]	-RRB-
cord-294366-swwz4kzd	31	42	)	)	-RRB-
cord-294366-swwz4kzd	32	1	and	and	CC
cord-294366-swwz4kzd	32	2	,	,	,
cord-294366-swwz4kzd	32	3	interestingly	interestingly	RB
cord-294366-swwz4kzd	32	4	,	,	,
cord-294366-swwz4kzd	32	5	variation	variation	NN
cord-294366-swwz4kzd	32	6	between	between	IN
cord-294366-swwz4kzd	32	7	propagated	propagate	VBN
cord-294366-swwz4kzd	32	8	strains	strain	NNS
cord-294366-swwz4kzd	32	9	of	of	IN
cord-294366-swwz4kzd	32	10	BCG	BCG	NNP
cord-294366-swwz4kzd	32	11	[	[	-LRB-
cord-294366-swwz4kzd	32	12	10	10	CD
cord-294366-swwz4kzd	32	13	]	]	-RRB-
cord-294366-swwz4kzd	32	14	.	.	.
cord-294366-swwz4kzd	33	1	In	in	IN
cord-294366-swwz4kzd	33	2	the	the	DT
cord-294366-swwz4kzd	33	3	case	case	NN
cord-294366-swwz4kzd	33	4	of	of	IN
cord-294366-swwz4kzd	33	5	TB	TB	NNP
cord-294366-swwz4kzd	33	6	,	,	,
cord-294366-swwz4kzd	33	7	recent	recent	JJ
cord-294366-swwz4kzd	33	8	literature	literature	NN
cord-294366-swwz4kzd	33	9	has	have	VBZ
cord-294366-swwz4kzd	33	10	correlated	correlate	VBN
cord-294366-swwz4kzd	33	11	the	the	DT
cord-294366-swwz4kzd	33	12	production	production	NN
cord-294366-swwz4kzd	33	13	of	of	IN
cord-294366-swwz4kzd	33	14	interleukin	interleukin	NN
cord-294366-swwz4kzd	33	15	4	4	CD
cord-294366-swwz4kzd	33	16	(	(	-LRB-
cord-294366-swwz4kzd	33	17	IL-4	IL-4	NNP
cord-294366-swwz4kzd	33	18	)	)	-RRB-
cord-294366-swwz4kzd	33	19	and	and	CC
cord-294366-swwz4kzd	33	20	IL-4δ2	IL-4δ2	NNP
cord-294366-swwz4kzd	33	21	(	(	-LRB-
cord-294366-swwz4kzd	33	22	a	a	DT
cord-294366-swwz4kzd	33	23	splice	splice	NN
cord-294366-swwz4kzd	33	24	variant	variant	NN
cord-294366-swwz4kzd	33	25	of	of	IN
cord-294366-swwz4kzd	33	26	IL-4	IL-4	NNP
cord-294366-swwz4kzd	33	27	and	and	CC
cord-294366-swwz4kzd	33	28	an	an	DT
cord-294366-swwz4kzd	33	29	IL-4	IL-4	NNP
cord-294366-swwz4kzd	33	30	antagonist	antagonist	NN
cord-294366-swwz4kzd	33	31	)	)	-RRB-
cord-294366-swwz4kzd	33	32	with	with	IN
cord-294366-swwz4kzd	33	33	the	the	DT
cord-294366-swwz4kzd	33	34	propensity	propensity	NN
cord-294366-swwz4kzd	33	35	of	of	IN
cord-294366-swwz4kzd	33	36	a	a	DT
cord-294366-swwz4kzd	33	37	latently	latently	RB
cord-294366-swwz4kzd	33	38	infected	infect	VBN
cord-294366-swwz4kzd	33	39	host	host	NN
cord-294366-swwz4kzd	33	40	to	to	TO
cord-294366-swwz4kzd	33	41	succumb	succumb	VB
cord-294366-swwz4kzd	33	42	to	to	IN
cord-294366-swwz4kzd	33	43	active	active	JJ
cord-294366-swwz4kzd	33	44	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	33	45	.	.	.
cord-294366-swwz4kzd	34	1	The	the	DT
cord-294366-swwz4kzd	34	2	production	production	NN
cord-294366-swwz4kzd	34	3	of	of	IN
cord-294366-swwz4kzd	34	4	IL-4δ2	IL-4δ2	NNP
cord-294366-swwz4kzd	34	5	is	be	VBZ
cord-294366-swwz4kzd	34	6	correlated	correlate	VBN
cord-294366-swwz4kzd	34	7	with	with	IN
cord-294366-swwz4kzd	34	8	the	the	DT
cord-294366-swwz4kzd	34	9	control	control	NN
cord-294366-swwz4kzd	34	10	of	of	IN
cord-294366-swwz4kzd	34	11	the	the	DT
cord-294366-swwz4kzd	34	12	disease	disease	NN
cord-294366-swwz4kzd	34	13	[	[	-LRB-
cord-294366-swwz4kzd	34	14	11	11	CD
cord-294366-swwz4kzd	34	15	]	]	-RRB-
cord-294366-swwz4kzd	34	16	.	.	.
cord-294366-swwz4kzd	35	1	Focus	focus	VB
cord-294366-swwz4kzd	35	2	on	on	IN
cord-294366-swwz4kzd	35	3	the	the	DT
cord-294366-swwz4kzd	35	4	type	type	NN
cord-294366-swwz4kzd	35	5	of	of	IN
cord-294366-swwz4kzd	35	6	immune	immune	JJ
cord-294366-swwz4kzd	35	7	response	response	NN
cord-294366-swwz4kzd	35	8	needed	need	VBN
cord-294366-swwz4kzd	35	9	to	to	TO
cord-294366-swwz4kzd	35	10	engender	engender	VB
cord-294366-swwz4kzd	35	11	protection	protection	NN
cord-294366-swwz4kzd	35	12	against	against	IN
cord-294366-swwz4kzd	35	13	TB	TB	NNP
cord-294366-swwz4kzd	35	14	seems	seem	VBZ
cord-294366-swwz4kzd	35	15	to	to	TO
cord-294366-swwz4kzd	35	16	be	be	VB
cord-294366-swwz4kzd	35	17	orientated	orientate	VBN
cord-294366-swwz4kzd	35	18	(	(	-LRB-
cord-294366-swwz4kzd	35	19	convincingly	convincingly	RB
cord-294366-swwz4kzd	35	20	)	)	-RRB-
cord-294366-swwz4kzd	35	21	towards	towards	IN
cord-294366-swwz4kzd	35	22	suppression	suppression	NN
cord-294366-swwz4kzd	35	23	of	of	IN
cord-294366-swwz4kzd	35	24	IL-4	IL-4	NNP
cord-294366-swwz4kzd	35	25	and	and	CC
cord-294366-swwz4kzd	35	26	the	the	DT
cord-294366-swwz4kzd	35	27	long	long	JJ
cord-294366-swwz4kzd	35	28	standing	standing	NN
cord-294366-swwz4kzd	35	29	dogma	dogma	NN
cord-294366-swwz4kzd	35	30	advocating	advocate	VBG
cord-294366-swwz4kzd	35	31	the	the	DT
cord-294366-swwz4kzd	35	32	importance	importance	NN
cord-294366-swwz4kzd	35	33	of	of	IN
cord-294366-swwz4kzd	35	34	Th1	th1	NN
cord-294366-swwz4kzd	35	35	type	type	NN
cord-294366-swwz4kzd	35	36	cytokines	cytokine	NNS
cord-294366-swwz4kzd	35	37	(	(	-LRB-
cord-294366-swwz4kzd	35	38	such	such	JJ
cord-294366-swwz4kzd	35	39	as	as	IN
cord-294366-swwz4kzd	35	40	interferon	interferon	NN
cord-294366-swwz4kzd	35	41	gamma	gamma	NN
cord-294366-swwz4kzd	35	42	,	,	,
cord-294366-swwz4kzd	35	43	IFN	IFN	NNP
cord-294366-swwz4kzd	35	44	-	-	HYPH
cord-294366-swwz4kzd	35	45	γ	γ	NNP
cord-294366-swwz4kzd	35	46	)	)	-RRB-
cord-294366-swwz4kzd	35	47	in	in	IN
cord-294366-swwz4kzd	35	48	TB	TB	NNP
cord-294366-swwz4kzd	35	49	resistance	resistance	NN
cord-294366-swwz4kzd	35	50	[	[	-LRB-
cord-294366-swwz4kzd	35	51	12	12	CD
cord-294366-swwz4kzd	35	52	,	,	,
cord-294366-swwz4kzd	35	53	13	13	CD
cord-294366-swwz4kzd	35	54	]	]	-RRB-
cord-294366-swwz4kzd	35	55	.	.	.
cord-294366-swwz4kzd	36	1	In	in	IN
cord-294366-swwz4kzd	36	2	the	the	DT
cord-294366-swwz4kzd	36	3	case	case	NN
cord-294366-swwz4kzd	36	4	of	of	IN
cord-294366-swwz4kzd	36	5	HIV	HIV	NNP
cord-294366-swwz4kzd	36	6	,	,	,
cord-294366-swwz4kzd	36	7	only	only	RB
cord-294366-swwz4kzd	36	8	one	one	CD
cord-294366-swwz4kzd	36	9	HIV	HIV	NNP
cord-294366-swwz4kzd	36	10	candidate	candidate	NN
cord-294366-swwz4kzd	36	11	vaccine	vaccine	NN
cord-294366-swwz4kzd	36	12	has	have	VBZ
cord-294366-swwz4kzd	36	13	completed	complete	VBN
cord-294366-swwz4kzd	36	14	clinical	clinical	JJ
cord-294366-swwz4kzd	36	15	trials	trial	NNS
cord-294366-swwz4kzd	36	16	Phases	phase	NNS
cord-294366-swwz4kzd	37	1	I	-PRON-	PRP
cord-294366-swwz4kzd	37	2	,	,	,
cord-294366-swwz4kzd	37	3	II	II	NNP
cord-294366-swwz4kzd	37	4	and	and	CC
cord-294366-swwz4kzd	37	5	III	iii	CD
cord-294366-swwz4kzd	37	6	in	in	IN
cord-294366-swwz4kzd	37	7	more	more	JJR
cord-294366-swwz4kzd	37	8	than	than	IN
cord-294366-swwz4kzd	37	9	20	20	CD
cord-294366-swwz4kzd	37	10	years	year	NNS
cord-294366-swwz4kzd	37	11	of	of	IN
cord-294366-swwz4kzd	37	12	the	the	DT
cord-294366-swwz4kzd	37	13	epidemic	epidemic	NN
cord-294366-swwz4kzd	37	14	.	.	.
cord-294366-swwz4kzd	38	1	The	the	DT
cord-294366-swwz4kzd	38	2	Phase	Phase	NNP
cord-294366-swwz4kzd	38	3	III	III	NNP
cord-294366-swwz4kzd	38	4	trial	trial	NN
cord-294366-swwz4kzd	38	5	was	be	VBD
cord-294366-swwz4kzd	38	6	based	base	VBN
cord-294366-swwz4kzd	38	7	on	on	IN
cord-294366-swwz4kzd	38	8	the	the	DT
cord-294366-swwz4kzd	38	9	use	use	NN
cord-294366-swwz4kzd	38	10	of	of	IN
cord-294366-swwz4kzd	38	11	recombinant	recombinant	JJ
cord-294366-swwz4kzd	38	12	envelope	envelope	NN
cord-294366-swwz4kzd	38	13	proteins	protein	NNS
cord-294366-swwz4kzd	38	14	,	,	,
cord-294366-swwz4kzd	38	15	with	with	IN
cord-294366-swwz4kzd	38	16	the	the	DT
cord-294366-swwz4kzd	38	17	aim	aim	NN
cord-294366-swwz4kzd	38	18	of	of	IN
cord-294366-swwz4kzd	38	19	evoking	evoke	VBG
cord-294366-swwz4kzd	38	20	virus	virus	NN
cord-294366-swwz4kzd	38	21	neutralizing	neutralize	VBG
cord-294366-swwz4kzd	38	22	antibodies	antibody	NNS
cord-294366-swwz4kzd	38	23	.	.	.
cord-294366-swwz4kzd	39	1	However	however	RB
cord-294366-swwz4kzd	39	2	,	,	,
cord-294366-swwz4kzd	39	3	results	result	VBZ
cord-294366-swwz4kzd	39	4	from	from	IN
cord-294366-swwz4kzd	39	5	this	this	DT
cord-294366-swwz4kzd	39	6	were	be	VBD
cord-294366-swwz4kzd	39	7	disappointing	disappointing	JJ
cord-294366-swwz4kzd	39	8	.	.	.
cord-294366-swwz4kzd	40	1	Currently	currently	RB
cord-294366-swwz4kzd	40	2	available	available	JJ
cord-294366-swwz4kzd	40	3	vaccines	vaccine	NNS
cord-294366-swwz4kzd	40	4	are	be	VBP
cord-294366-swwz4kzd	40	5	mostly	mostly	RB
cord-294366-swwz4kzd	40	6	effective	effective	JJ
cord-294366-swwz4kzd	40	7	against	against	IN
cord-294366-swwz4kzd	40	8	viral	viral	JJ
cord-294366-swwz4kzd	40	9	diseases	disease	NNS
cord-294366-swwz4kzd	40	10	that	that	WDT
cord-294366-swwz4kzd	40	11	are	be	VBP
cord-294366-swwz4kzd	40	12	normally	normally	RB
cord-294366-swwz4kzd	40	13	cleared	clear	VBN
cord-294366-swwz4kzd	40	14	during	during	IN
cord-294366-swwz4kzd	40	15	natural	natural	JJ
cord-294366-swwz4kzd	40	16	infection	infection	NN
cord-294366-swwz4kzd	40	17	[	[	-LRB-
cord-294366-swwz4kzd	40	18	influenza	influenza	NN
cord-294366-swwz4kzd	40	19	,	,	,
cord-294366-swwz4kzd	40	20	smallpox	smallpox	NN
cord-294366-swwz4kzd	40	21	,	,	,
cord-294366-swwz4kzd	40	22	polio	polio	NN
cord-294366-swwz4kzd	40	23	and	and	CC
cord-294366-swwz4kzd	40	24	all	all	DT
cord-294366-swwz4kzd	40	25	three	three	CD
cord-294366-swwz4kzd	40	26	viruses	virus	NNS
cord-294366-swwz4kzd	40	27	in	in	IN
cord-294366-swwz4kzd	40	28	the	the	DT
cord-294366-swwz4kzd	40	29	measles	measle	NNS
cord-294366-swwz4kzd	40	30	,	,	,
cord-294366-swwz4kzd	40	31	mumps	mumps	NN
cord-294366-swwz4kzd	40	32	and	and	CC
cord-294366-swwz4kzd	40	33	rubella	rubella	NN
cord-294366-swwz4kzd	40	34	(	(	-LRB-
cord-294366-swwz4kzd	40	35	MMR	MMR	NNP
cord-294366-swwz4kzd	40	36	)	)	-RRB-
cord-294366-swwz4kzd	40	37	immunisation	immunisation	NN
cord-294366-swwz4kzd	40	38	]	]	-RRB-
cord-294366-swwz4kzd	40	39	.	.	.
cord-294366-swwz4kzd	41	1	HIV	HIV	NNP
cord-294366-swwz4kzd	41	2	,	,	,
cord-294366-swwz4kzd	41	3	in	in	IN
cord-294366-swwz4kzd	41	4	common	common	JJ
cord-294366-swwz4kzd	41	5	with	with	IN
cord-294366-swwz4kzd	41	6	Epstein	Epstein	NNP
cord-294366-swwz4kzd	41	7	-	-	HYPH
cord-294366-swwz4kzd	41	8	Barr	Barr	NNP
cord-294366-swwz4kzd	41	9	virus	virus	NN
cord-294366-swwz4kzd	41	10	,	,	,
cord-294366-swwz4kzd	41	11	cytomegalovirus	cytomegalovirus	NNP
cord-294366-swwz4kzd	41	12	,	,	,
cord-294366-swwz4kzd	41	13	hepatitis	hepatitis	NNP
cord-294366-swwz4kzd	41	14	(	(	-LRB-
cord-294366-swwz4kzd	41	15	B	b	NN
cord-294366-swwz4kzd	41	16	and	and	CC
cord-294366-swwz4kzd	41	17	C	C	NNP
cord-294366-swwz4kzd	41	18	)	)	-RRB-
cord-294366-swwz4kzd	41	19	and	and	CC
cord-294366-swwz4kzd	41	20	herpes	herpes	NN
cord-294366-swwz4kzd	41	21	simplex	simplex	NNP
cord-294366-swwz4kzd	41	22	virus	virus	NN
cord-294366-swwz4kzd	41	23	,	,	,
cord-294366-swwz4kzd	41	24	normally	normally	RB
cord-294366-swwz4kzd	41	25	establishes	establish	VBZ
cord-294366-swwz4kzd	41	26	chronic	chronic	JJ
cord-294366-swwz4kzd	41	27	infection	infection	NN
cord-294366-swwz4kzd	41	28	.	.	.
cord-294366-swwz4kzd	42	1	Opinion	opinion	NN
cord-294366-swwz4kzd	42	2	is	be	VBZ
cord-294366-swwz4kzd	42	3	divided	divide	VBN
cord-294366-swwz4kzd	42	4	as	as	IN
cord-294366-swwz4kzd	42	5	to	to	IN
cord-294366-swwz4kzd	42	6	what	what	WDT
cord-294366-swwz4kzd	42	7	type	type	NN
cord-294366-swwz4kzd	42	8	of	of	IN
cord-294366-swwz4kzd	42	9	immune	immune	JJ
cord-294366-swwz4kzd	42	10	response	response	NN
cord-294366-swwz4kzd	42	11	is	be	VBZ
cord-294366-swwz4kzd	42	12	required	require	VBN
cord-294366-swwz4kzd	42	13	in	in	IN
cord-294366-swwz4kzd	42	14	the	the	DT
cord-294366-swwz4kzd	42	15	control	control	NN
cord-294366-swwz4kzd	42	16	of	of	IN
cord-294366-swwz4kzd	42	17	HIV	HIV	NNP
cord-294366-swwz4kzd	42	18	.	.	.
cord-294366-swwz4kzd	43	1	Neutralizing	neutralize	VBG
cord-294366-swwz4kzd	43	2	antibodies	antibody	NNS
cord-294366-swwz4kzd	43	3	might	may	MD
cord-294366-swwz4kzd	43	4	be	be	VB
cord-294366-swwz4kzd	43	5	efficient	efficient	JJ
cord-294366-swwz4kzd	43	6	in	in	IN
cord-294366-swwz4kzd	43	7	blocking	block	VBG
cord-294366-swwz4kzd	43	8	virus	virus	NN
cord-294366-swwz4kzd	43	9	particles	particle	NNS
cord-294366-swwz4kzd	43	10	but	but	CC
cord-294366-swwz4kzd	43	11	poorly	poorly	RB
cord-294366-swwz4kzd	43	12	effective	effective	JJ
cord-294366-swwz4kzd	43	13	against	against	IN
cord-294366-swwz4kzd	43	14	cellassociated	cellassociate	VBN
cord-294366-swwz4kzd	43	15	virus	virus	NN
cord-294366-swwz4kzd	43	16	,	,	,
cord-294366-swwz4kzd	43	17	whereas	whereas	IN
cord-294366-swwz4kzd	43	18	some	some	DT
cord-294366-swwz4kzd	43	19	cytotoxic	cytotoxic	JJ
cord-294366-swwz4kzd	43	20	T	t	NN
cord-294366-swwz4kzd	43	21	lymphocytes	lymphocyte	NNS
cord-294366-swwz4kzd	43	22	(	(	-LRB-
cord-294366-swwz4kzd	43	23	CTLs	CTLs	NNP
cord-294366-swwz4kzd	43	24	)	)	-RRB-
cord-294366-swwz4kzd	43	25	are	be	VBP
cord-294366-swwz4kzd	43	26	effective	effective	JJ
cord-294366-swwz4kzd	43	27	against	against	IN
cord-294366-swwz4kzd	43	28	virally	virally	RB
cord-294366-swwz4kzd	43	29	infected	infect	VBN
cord-294366-swwz4kzd	43	30	cells	cell	NNS
cord-294366-swwz4kzd	43	31	but	but	CC
cord-294366-swwz4kzd	43	32	not	not	RB
cord-294366-swwz4kzd	43	33	against	against	IN
cord-294366-swwz4kzd	43	34	free	free	JJ
cord-294366-swwz4kzd	43	35	virus	virus	NN
cord-294366-swwz4kzd	43	36	particles	particle	NNS
cord-294366-swwz4kzd	43	37	.	.	.
cord-294366-swwz4kzd	44	1	Latent	latent	JJ
cord-294366-swwz4kzd	44	2	infection	infection	NN
cord-294366-swwz4kzd	44	3	facilitates	facilitate	VBZ
cord-294366-swwz4kzd	44	4	immune	immune	JJ
cord-294366-swwz4kzd	44	5	evasion	evasion	NN
cord-294366-swwz4kzd	44	6	and	and	CC
cord-294366-swwz4kzd	44	7	the	the	DT
cord-294366-swwz4kzd	44	8	rate	rate	NN
cord-294366-swwz4kzd	44	9	of	of	IN
cord-294366-swwz4kzd	44	10	mutation	mutation	NN
cord-294366-swwz4kzd	44	11	inherent	inherent	JJ
cord-294366-swwz4kzd	44	12	in	in	IN
cord-294366-swwz4kzd	44	13	HIV	HIV	NNP
cord-294366-swwz4kzd	44	14	also	also	RB
cord-294366-swwz4kzd	44	15	facilitates	facilitate	VBZ
cord-294366-swwz4kzd	44	16	evasion	evasion	NN
cord-294366-swwz4kzd	44	17	(	(	-LRB-
cord-294366-swwz4kzd	44	18	by	by	IN
cord-294366-swwz4kzd	44	19	escape	escape	NN
cord-294366-swwz4kzd	44	20	from	from	IN
cord-294366-swwz4kzd	44	21	responding	respond	VBG
cord-294366-swwz4kzd	44	22	T	T	NNP
cord-294366-swwz4kzd	44	23	cells	cell	NNS
cord-294366-swwz4kzd	44	24	[	[	-LRB-
cord-294366-swwz4kzd	44	25	14	14	CD
cord-294366-swwz4kzd	44	26	]	]	-RRB-
cord-294366-swwz4kzd	44	27	)	)	-RRB-
cord-294366-swwz4kzd	44	28	.	.	.
cord-294366-swwz4kzd	45	1	Promising	promising	JJ
cord-294366-swwz4kzd	45	2	vaccine	vaccine	NN
cord-294366-swwz4kzd	45	3	strategies	strategy	NNS
cord-294366-swwz4kzd	45	4	will	will	MD
cord-294366-swwz4kzd	45	5	likely	likely	RB
cord-294366-swwz4kzd	45	6	depend	depend	VB
cord-294366-swwz4kzd	45	7	upon	upon	IN
cord-294366-swwz4kzd	45	8	highly	highly	RB
cord-294366-swwz4kzd	45	9	conserved	conserve	VBN
cord-294366-swwz4kzd	45	10	epitopes	epitope	NNS
cord-294366-swwz4kzd	45	11	and	and	CC
cord-294366-swwz4kzd	45	12	upon	upon	IN
cord-294366-swwz4kzd	45	13	vaccine	vaccine	NN
cord-294366-swwz4kzd	45	14	strategies	strategy	NNS
cord-294366-swwz4kzd	45	15	that	that	WDT
cord-294366-swwz4kzd	45	16	induce	induce	VBP
cord-294366-swwz4kzd	45	17	potent	potent	JJ
cord-294366-swwz4kzd	45	18	immune	immune	JJ
cord-294366-swwz4kzd	45	19	responses	response	NNS
cord-294366-swwz4kzd	45	20	capable	capable	JJ
cord-294366-swwz4kzd	45	21	of	of	IN
cord-294366-swwz4kzd	45	22	driving	drive	VBG
cord-294366-swwz4kzd	45	23	cytotoxicity	cytotoxicity	NN
cord-294366-swwz4kzd	45	24	and	and	CC
cord-294366-swwz4kzd	45	25	producing	produce	VBG
cord-294366-swwz4kzd	45	26	broadly	broadly	RB
cord-294366-swwz4kzd	45	27	effective	effective	JJ
cord-294366-swwz4kzd	45	28	neutralizing	neutralize	VBG
cord-294366-swwz4kzd	45	29	antibodies	antibody	NNS
cord-294366-swwz4kzd	45	30	[	[	-LRB-
cord-294366-swwz4kzd	45	31	15	15	CD
cord-294366-swwz4kzd	45	32	]	]	-RRB-
cord-294366-swwz4kzd	45	33	.	.	.
cord-294366-swwz4kzd	46	1	Allergic	allergic	JJ
cord-294366-swwz4kzd	46	2	and	and	CC
cord-294366-swwz4kzd	46	3	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	46	4	diseases	disease	NNS
cord-294366-swwz4kzd	46	5	represent	represent	VBP
cord-294366-swwz4kzd	46	6	undesired	undesired	JJ
cord-294366-swwz4kzd	46	7	hypersensitive	hypersensitive	JJ
cord-294366-swwz4kzd	46	8	immune	immune	JJ
cord-294366-swwz4kzd	46	9	responses	response	NNS
cord-294366-swwz4kzd	46	10	to	to	IN
cord-294366-swwz4kzd	46	11	normally	normally	RB
cord-294366-swwz4kzd	46	12	harmless	harmless	JJ
cord-294366-swwz4kzd	46	13	environmental	environmental	JJ
cord-294366-swwz4kzd	46	14	antigens	antigen	NNS
cord-294366-swwz4kzd	46	15	,	,	,
cord-294366-swwz4kzd	46	16	in	in	IN
cord-294366-swwz4kzd	46	17	the	the	DT
cord-294366-swwz4kzd	46	18	case	case	NN
cord-294366-swwz4kzd	46	19	of	of	IN
cord-294366-swwz4kzd	46	20	allergy	allergy	NN
cord-294366-swwz4kzd	46	21	,	,	,
cord-294366-swwz4kzd	46	22	or	or	CC
cord-294366-swwz4kzd	46	23	normally	normally	RB
cord-294366-swwz4kzd	46	24	tolerated	tolerate	VBD
cord-294366-swwz4kzd	46	25	self	self	NN
cord-294366-swwz4kzd	46	26	-	-	HYPH
cord-294366-swwz4kzd	46	27	proteins	protein	NNS
cord-294366-swwz4kzd	46	28	,	,	,
cord-294366-swwz4kzd	46	29	in	in	IN
cord-294366-swwz4kzd	46	30	the	the	DT
cord-294366-swwz4kzd	46	31	case	case	NN
cord-294366-swwz4kzd	46	32	of	of	IN
cord-294366-swwz4kzd	46	33	autoimmunity	autoimmunity	NN
cord-294366-swwz4kzd	46	34	.	.	.
cord-294366-swwz4kzd	47	1	The	the	DT
cord-294366-swwz4kzd	47	2	understanding	understanding	NN
cord-294366-swwz4kzd	47	3	of	of	IN
cord-294366-swwz4kzd	47	4	the	the	DT
cord-294366-swwz4kzd	47	5	pathogenesis	pathogenesis	NN
cord-294366-swwz4kzd	47	6	of	of	IN
cord-294366-swwz4kzd	47	7	allergic	allergic	JJ
cord-294366-swwz4kzd	47	8	and	and	CC
cord-294366-swwz4kzd	47	9	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	47	10	diseases	disease	NNS
cord-294366-swwz4kzd	47	11	has	have	VBZ
cord-294366-swwz4kzd	47	12	led	lead	VBN
cord-294366-swwz4kzd	47	13	to	to	IN
cord-294366-swwz4kzd	47	14	several	several	JJ
cord-294366-swwz4kzd	47	15	proposed	propose	VBN
cord-294366-swwz4kzd	47	16	associations	association	NNS
cord-294366-swwz4kzd	47	17	and	and	CC
cord-294366-swwz4kzd	47	18	causes	cause	NNS
cord-294366-swwz4kzd	47	19	for	for	IN
cord-294366-swwz4kzd	47	20	these	these	DT
cord-294366-swwz4kzd	47	21	diseases	disease	NNS
cord-294366-swwz4kzd	47	22	.	.	.
cord-294366-swwz4kzd	48	1	It	-PRON-	PRP
cord-294366-swwz4kzd	48	2	has	have	VBZ
cord-294366-swwz4kzd	48	3	been	be	VBN
cord-294366-swwz4kzd	48	4	shown	show	VBN
cord-294366-swwz4kzd	48	5	that	that	IN
cord-294366-swwz4kzd	48	6	highaffinity	highaffinity	NN
cord-294366-swwz4kzd	48	7	T	t	NN
cord-294366-swwz4kzd	48	8	cells	cell	NNS
cord-294366-swwz4kzd	48	9	can	can	MD
cord-294366-swwz4kzd	48	10	out	out	RB
cord-294366-swwz4kzd	48	11	-	-	HYPH
cord-294366-swwz4kzd	48	12	compete	compete	VB
cord-294366-swwz4kzd	48	13	lower	low	JJR
cord-294366-swwz4kzd	48	14	-	-	HYPH
cord-294366-swwz4kzd	48	15	affinity	affinity	NN
cord-294366-swwz4kzd	48	16	T	t	NN
cord-294366-swwz4kzd	48	17	cells	cell	NNS
cord-294366-swwz4kzd	48	18	during	during	IN
cord-294366-swwz4kzd	48	19	responses	response	NNS
cord-294366-swwz4kzd	48	20	to	to	IN
cord-294366-swwz4kzd	48	21	antigen	antigen	NN
cord-294366-swwz4kzd	48	22	in	in	IN
cord-294366-swwz4kzd	48	23	vivo	vivo	NN
cord-294366-swwz4kzd	48	24	[	[	-LRB-
cord-294366-swwz4kzd	48	25	16	16	CD
cord-294366-swwz4kzd	48	26	]	]	-RRB-
cord-294366-swwz4kzd	48	27	.	.	.
cord-294366-swwz4kzd	49	1	Competition	competition	NN
cord-294366-swwz4kzd	49	2	between	between	IN
cord-294366-swwz4kzd	49	3	T	t	NN
cord-294366-swwz4kzd	49	4	cells	cell	NNS
cord-294366-swwz4kzd	49	5	provides	provide	VBZ
cord-294366-swwz4kzd	49	6	the	the	DT
cord-294366-swwz4kzd	49	7	basis	basis	NN
cord-294366-swwz4kzd	49	8	for	for	IN
cord-294366-swwz4kzd	49	9	the	the	DT
cord-294366-swwz4kzd	49	10	argument	argument	NN
cord-294366-swwz4kzd	49	11	that	that	IN
cord-294366-swwz4kzd	49	12	maintaining	maintain	VBG
cord-294366-swwz4kzd	49	13	a	a	DT
cord-294366-swwz4kzd	49	14	balanced	balanced	JJ
cord-294366-swwz4kzd	49	15	peripheral	peripheral	JJ
cord-294366-swwz4kzd	49	16	immune	immune	JJ
cord-294366-swwz4kzd	49	17	system	system	NN
cord-294366-swwz4kzd	49	18	might	may	MD
cord-294366-swwz4kzd	49	19	also	also	RB
cord-294366-swwz4kzd	49	20	be	be	VB
cord-294366-swwz4kzd	49	21	a	a	DT
cord-294366-swwz4kzd	49	22	side	side	JJ
cord-294366-swwz4kzd	49	23	effect	effect	NN
cord-294366-swwz4kzd	49	24	of	of	IN
cord-294366-swwz4kzd	49	25	normal	normal	JJ
cord-294366-swwz4kzd	49	26	competition	competition	NN
cord-294366-swwz4kzd	49	27	for	for	IN
cord-294366-swwz4kzd	49	28	shared	share	VBN
cord-294366-swwz4kzd	49	29	resources	resource	NNS
cord-294366-swwz4kzd	49	30	within	within	IN
cord-294366-swwz4kzd	49	31	an	an	DT
cord-294366-swwz4kzd	49	32	intact	intact	JJ
cord-294366-swwz4kzd	49	33	immune	immune	JJ
cord-294366-swwz4kzd	49	34	system	system	NN
cord-294366-swwz4kzd	49	35	[	[	-LRB-
cord-294366-swwz4kzd	49	36	17	17	CD
cord-294366-swwz4kzd	49	37	]	]	-RRB-
cord-294366-swwz4kzd	49	38	,	,	,
cord-294366-swwz4kzd	49	39	a	a	DT
cord-294366-swwz4kzd	49	40	mechanism	mechanism	NN
cord-294366-swwz4kzd	49	41	proposed	propose	VBN
cord-294366-swwz4kzd	49	42	to	to	TO
cord-294366-swwz4kzd	49	43	be	be	VB
cord-294366-swwz4kzd	49	44	responsible	responsible	JJ
cord-294366-swwz4kzd	49	45	for	for	IN
cord-294366-swwz4kzd	49	46	the	the	DT
cord-294366-swwz4kzd	49	47	increased	increase	VBN
cord-294366-swwz4kzd	49	48	occurrence	occurrence	NN
cord-294366-swwz4kzd	49	49	of	of	IN
cord-294366-swwz4kzd	49	50	these	these	DT
cord-294366-swwz4kzd	49	51	diseases	disease	NNS
cord-294366-swwz4kzd	49	52	,	,	,
cord-294366-swwz4kzd	49	53	where	where	WRB
cord-294366-swwz4kzd	49	54	hypersensitivity	hypersensitivity	NN
cord-294366-swwz4kzd	49	55	is	be	VBZ
cord-294366-swwz4kzd	49	56	normally	normally	RB
cord-294366-swwz4kzd	49	57	passively	passively	RB
cord-294366-swwz4kzd	49	58	controlled	control	VBN
cord-294366-swwz4kzd	49	59	by	by	IN
cord-294366-swwz4kzd	49	60	expansion	expansion	NN
cord-294366-swwz4kzd	49	61	of	of	IN
cord-294366-swwz4kzd	49	62	immune	immune	JJ
cord-294366-swwz4kzd	49	63	cells	cell	NNS
cord-294366-swwz4kzd	49	64	specific	specific	JJ
cord-294366-swwz4kzd	49	65	for	for	IN
cord-294366-swwz4kzd	49	66	prevalent	prevalent	JJ
cord-294366-swwz4kzd	49	67	infectious	infectious	JJ
cord-294366-swwz4kzd	49	68	agents	agent	NNS
cord-294366-swwz4kzd	49	69	.	.	.
cord-294366-swwz4kzd	50	1	Autoimmunity	autoimmunity	NN
cord-294366-swwz4kzd	50	2	can	can	MD
cord-294366-swwz4kzd	50	3	have	have	VB
cord-294366-swwz4kzd	50	4	strong	strong	JJ
cord-294366-swwz4kzd	50	5	associations	association	NNS
cord-294366-swwz4kzd	50	6	with	with	IN
cord-294366-swwz4kzd	50	7	exposure	exposure	NN
cord-294366-swwz4kzd	50	8	to	to	IN
cord-294366-swwz4kzd	50	9	crossreactive	crossreactive	JJ
cord-294366-swwz4kzd	50	10	proteins	protein	NNS
cord-294366-swwz4kzd	50	11	,	,	,
cord-294366-swwz4kzd	50	12	and	and	CC
cord-294366-swwz4kzd	50	13	genes	gene	NNS
cord-294366-swwz4kzd	50	14	encoding	encode	VBG
cord-294366-swwz4kzd	50	15	major	major	JJ
cord-294366-swwz4kzd	50	16	histocompatibility	histocompatibility	NN
cord-294366-swwz4kzd	50	17	complex	complex	NN
cord-294366-swwz4kzd	50	18	(	(	-LRB-
cord-294366-swwz4kzd	50	19	MHC	MHC	NNP
cord-294366-swwz4kzd	50	20	)	)	-RRB-
cord-294366-swwz4kzd	51	1	are	be	VBP
cord-294366-swwz4kzd	51	2	strongly	strongly	RB
cord-294366-swwz4kzd	51	3	associated	associate	VBN
cord-294366-swwz4kzd	51	4	with	with	IN
cord-294366-swwz4kzd	51	5	some	some	DT
cord-294366-swwz4kzd	51	6	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	51	7	diseases	disease	NNS
cord-294366-swwz4kzd	51	8	,	,	,
cord-294366-swwz4kzd	51	9	but	but	CC
cord-294366-swwz4kzd	51	10	this	this	DT
cord-294366-swwz4kzd	51	11	is	be	VBZ
cord-294366-swwz4kzd	51	12	markedly	markedly	RB
cord-294366-swwz4kzd	51	13	less	less	RBR
cord-294366-swwz4kzd	51	14	so	so	RB
cord-294366-swwz4kzd	51	15	for	for	IN
cord-294366-swwz4kzd	51	16	allergy	allergy	NN
cord-294366-swwz4kzd	51	17	.	.	.
cord-294366-swwz4kzd	52	1	Allergy	allergy	NN
cord-294366-swwz4kzd	52	2	and	and	CC
cord-294366-swwz4kzd	52	3	autoimmunity	autoimmunity	NN
cord-294366-swwz4kzd	52	4	are	be	VBP
cord-294366-swwz4kzd	52	5	thought	think	VBN
cord-294366-swwz4kzd	52	6	to	to	TO
cord-294366-swwz4kzd	52	7	differ	differ	VB
cord-294366-swwz4kzd	52	8	by	by	IN
cord-294366-swwz4kzd	52	9	virtue	virtue	NN
cord-294366-swwz4kzd	52	10	of	of	IN
cord-294366-swwz4kzd	52	11	their	-PRON-	PRP$
cord-294366-swwz4kzd	52	12	regulation	regulation	NN
cord-294366-swwz4kzd	52	13	through	through	IN
cord-294366-swwz4kzd	52	14	central	central	JJ
cord-294366-swwz4kzd	52	15	and	and	CC
cord-294366-swwz4kzd	52	16	peripheral	peripheral	JJ
cord-294366-swwz4kzd	52	17	tolerance	tolerance	NN
cord-294366-swwz4kzd	52	18	.	.	.
cord-294366-swwz4kzd	53	1	Genetic	genetic	JJ
cord-294366-swwz4kzd	53	2	predisposition	predisposition	NN
cord-294366-swwz4kzd	53	3	and	and	CC
cord-294366-swwz4kzd	53	4	environmental	environmental	JJ
cord-294366-swwz4kzd	53	5	exposure	exposure	NN
cord-294366-swwz4kzd	53	6	are	be	VBP
cord-294366-swwz4kzd	53	7	believed	believe	VBN
cord-294366-swwz4kzd	53	8	to	to	TO
cord-294366-swwz4kzd	53	9	play	play	VB
cord-294366-swwz4kzd	53	10	key	key	JJ
cord-294366-swwz4kzd	53	11	roles	role	NNS
cord-294366-swwz4kzd	53	12	in	in	IN
cord-294366-swwz4kzd	53	13	the	the	DT
cord-294366-swwz4kzd	53	14	development	development	NN
cord-294366-swwz4kzd	53	15	of	of	IN
cord-294366-swwz4kzd	53	16	asthma	asthma	NN
cord-294366-swwz4kzd	53	17	and	and	CC
cord-294366-swwz4kzd	53	18	atopy	atopy	NN
cord-294366-swwz4kzd	53	19	[	[	-LRB-
cord-294366-swwz4kzd	53	20	18	18	CD
cord-294366-swwz4kzd	53	21	]	]	-RRB-
cord-294366-swwz4kzd	53	22	,	,	,
cord-294366-swwz4kzd	53	23	with	with	IN
cord-294366-swwz4kzd	53	24	the	the	DT
cord-294366-swwz4kzd	53	25	significant	significant	JJ
cord-294366-swwz4kzd	53	26	increase	increase	NN
cord-294366-swwz4kzd	53	27	in	in	IN
cord-294366-swwz4kzd	53	28	the	the	DT
cord-294366-swwz4kzd	53	29	incidence	incidence	NN
cord-294366-swwz4kzd	53	30	of	of	IN
cord-294366-swwz4kzd	53	31	these	these	DT
cord-294366-swwz4kzd	53	32	disorders	disorder	NNS
cord-294366-swwz4kzd	53	33	thought	think	VBD
cord-294366-swwz4kzd	53	34	to	to	TO
cord-294366-swwz4kzd	53	35	provide	provide	VB
cord-294366-swwz4kzd	53	36	evidence	evidence	NN
cord-294366-swwz4kzd	53	37	for	for	IN
cord-294366-swwz4kzd	53	38	the	the	DT
cord-294366-swwz4kzd	53	39	involvement	involvement	NN
cord-294366-swwz4kzd	53	40	of	of	IN
cord-294366-swwz4kzd	53	41	various	various	JJ
cord-294366-swwz4kzd	53	42	environmental	environmental	JJ
cord-294366-swwz4kzd	53	43	factors	factor	NNS
cord-294366-swwz4kzd	53	44	,	,	,
cord-294366-swwz4kzd	53	45	especially	especially	RB
cord-294366-swwz4kzd	53	46	in	in	IN
cord-294366-swwz4kzd	53	47	developed	develop	VBN
cord-294366-swwz4kzd	53	48	countries	country	NNS
cord-294366-swwz4kzd	53	49	[	[	-LRB-
cord-294366-swwz4kzd	53	50	19	19	CD
cord-294366-swwz4kzd	53	51	]	]	-RRB-
cord-294366-swwz4kzd	53	52	.	.	.
cord-294366-swwz4kzd	54	1	The	the	DT
cord-294366-swwz4kzd	54	2	rationale	rationale	NN
cord-294366-swwz4kzd	54	3	for	for	IN
cord-294366-swwz4kzd	54	4	immunological	immunological	JJ
cord-294366-swwz4kzd	54	5	therapeutic	therapeutic	JJ
cord-294366-swwz4kzd	54	6	intervention	intervention	NN
cord-294366-swwz4kzd	54	7	is	be	VBZ
cord-294366-swwz4kzd	54	8	strongly	strongly	RB
cord-294366-swwz4kzd	54	9	supported	support	VBN
cord-294366-swwz4kzd	54	10	by	by	IN
cord-294366-swwz4kzd	54	11	the	the	DT
cord-294366-swwz4kzd	54	12	present	present	JJ
cord-294366-swwz4kzd	54	13	lack	lack	NN
cord-294366-swwz4kzd	54	14	of	of	IN
cord-294366-swwz4kzd	54	15	curative	curative	JJ
cord-294366-swwz4kzd	54	16	treatments	treatment	NNS
cord-294366-swwz4kzd	54	17	for	for	IN
cord-294366-swwz4kzd	54	18	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	54	19	and	and	CC
cord-294366-swwz4kzd	54	20	allergic	allergic	JJ
cord-294366-swwz4kzd	54	21	disorders	disorder	NNS
cord-294366-swwz4kzd	54	22	,	,	,
cord-294366-swwz4kzd	54	23	a	a	DT
cord-294366-swwz4kzd	54	24	growing	grow	VBG
cord-294366-swwz4kzd	54	25	unmet	unmet	JJ
cord-294366-swwz4kzd	54	26	need	need	NN
cord-294366-swwz4kzd	54	27	,	,	,
cord-294366-swwz4kzd	54	28	where	where	WRB
cord-294366-swwz4kzd	54	29	the	the	DT
cord-294366-swwz4kzd	54	30	largely	largely	RB
cord-294366-swwz4kzd	54	31	palliative	palliative	JJ
cord-294366-swwz4kzd	54	32	treatment	treatment	NN
cord-294366-swwz4kzd	54	33	is	be	VBZ
cord-294366-swwz4kzd	54	34	not	not	RB
cord-294366-swwz4kzd	54	35	without	without	IN
cord-294366-swwz4kzd	54	36	problems	problem	NNS
cord-294366-swwz4kzd	54	37	[	[	-LRB-
cord-294366-swwz4kzd	54	38	20	20	CD
cord-294366-swwz4kzd	54	39	]	]	-RRB-
cord-294366-swwz4kzd	54	40	.	.	.
cord-294366-swwz4kzd	55	1	Evidence	evidence	NN
cord-294366-swwz4kzd	55	2	that	that	IN
cord-294366-swwz4kzd	55	3	pathology	pathology	NN
cord-294366-swwz4kzd	55	4	associated	associate	VBN
cord-294366-swwz4kzd	55	5	with	with	IN
cord-294366-swwz4kzd	55	6	allergy	allergy	NN
cord-294366-swwz4kzd	55	7	and	and	CC
cord-294366-swwz4kzd	55	8	autoimmunity	autoimmunity	NN
cord-294366-swwz4kzd	55	9	is	be	VBZ
cord-294366-swwz4kzd	55	10	reversible	reversible	JJ
cord-294366-swwz4kzd	55	11	is	be	VBZ
cord-294366-swwz4kzd	55	12	provided	provide	VBN
cord-294366-swwz4kzd	55	13	by	by	IN
cord-294366-swwz4kzd	55	14	transient	transient	JJ
cord-294366-swwz4kzd	55	15	and	and	CC
cord-294366-swwz4kzd	55	16	long	long	JJ
cord-294366-swwz4kzd	55	17	-	-	HYPH
cord-294366-swwz4kzd	55	18	term	term	NN
cord-294366-swwz4kzd	55	19	resolution	resolution	NN
cord-294366-swwz4kzd	55	20	of	of	IN
cord-294366-swwz4kzd	55	21	disease	disease	NN
cord-294366-swwz4kzd	55	22	as	as	RB
cord-294366-swwz4kzd	55	23	well	well	RB
cord-294366-swwz4kzd	55	24	as	as	IN
cord-294366-swwz4kzd	55	25	by	by	IN
cord-294366-swwz4kzd	55	26	the	the	DT
cord-294366-swwz4kzd	55	27	success	success	NN
cord-294366-swwz4kzd	55	28	of	of	IN
cord-294366-swwz4kzd	55	29	specific	specific	JJ
cord-294366-swwz4kzd	55	30	allergen	allergen	NN
cord-294366-swwz4kzd	55	31	immunotherapy	immunotherapy	NN
cord-294366-swwz4kzd	55	32	,	,	,
cord-294366-swwz4kzd	55	33	where	where	WRB
cord-294366-swwz4kzd	55	34	subcutaneous	subcutaneous	JJ
cord-294366-swwz4kzd	55	35	or	or	CC
cord-294366-swwz4kzd	55	36	sublingual	sublingual	JJ
cord-294366-swwz4kzd	55	37	administration	administration	NN
cord-294366-swwz4kzd	55	38	of	of	IN
cord-294366-swwz4kzd	55	39	the	the	DT
cord-294366-swwz4kzd	55	40	sensitizing	sensitize	VBG
cord-294366-swwz4kzd	55	41	protein(s	protein(s	NNP
cord-294366-swwz4kzd	55	42	)	)	-RRB-
cord-294366-swwz4kzd	55	43	modifies	modify	VBZ
cord-294366-swwz4kzd	55	44	immunity	immunity	NN
cord-294366-swwz4kzd	55	45	and	and	CC
cord-294366-swwz4kzd	55	46	reduces	reduce	VBZ
cord-294366-swwz4kzd	55	47	allergen	allergen	NN
cord-294366-swwz4kzd	55	48	sensitivity	sensitivity	NN
cord-294366-swwz4kzd	55	49	[	[	-LRB-
cord-294366-swwz4kzd	55	50	20	20	CD
cord-294366-swwz4kzd	55	51	]	]	-RRB-
cord-294366-swwz4kzd	55	52	.	.	.
cord-294366-swwz4kzd	56	1	Serological	serological	JJ
cord-294366-swwz4kzd	56	2	identification	identification	NN
cord-294366-swwz4kzd	56	3	of	of	IN
cord-294366-swwz4kzd	56	4	antigens	antigen	NNS
cord-294366-swwz4kzd	56	5	by	by	IN
cord-294366-swwz4kzd	56	6	recombinant	recombinant	JJ
cord-294366-swwz4kzd	56	7	expression	expression	NN
cord-294366-swwz4kzd	56	8	cloning	cloning	NN
cord-294366-swwz4kzd	56	9	has	have	VBZ
cord-294366-swwz4kzd	56	10	led	lead	VBN
cord-294366-swwz4kzd	56	11	to	to	IN
cord-294366-swwz4kzd	56	12	the	the	DT
cord-294366-swwz4kzd	56	13	identification	identification	NN
cord-294366-swwz4kzd	56	14	of	of	IN
cord-294366-swwz4kzd	56	15	a	a	DT
cord-294366-swwz4kzd	56	16	multitude	multitude	NN
cord-294366-swwz4kzd	56	17	of	of	IN
cord-294366-swwz4kzd	56	18	new	new	JJ
cord-294366-swwz4kzd	56	19	tumour	tumour	NN
cord-294366-swwz4kzd	56	20	antigens	antigen	NNS
cord-294366-swwz4kzd	56	21	[	[	-LRB-
cord-294366-swwz4kzd	56	22	21	21	CD
cord-294366-swwz4kzd	56	23	]	]	-RRB-
cord-294366-swwz4kzd	56	24	.	.	.
cord-294366-swwz4kzd	57	1	It	-PRON-	PRP
cord-294366-swwz4kzd	57	2	is	be	VBZ
cord-294366-swwz4kzd	57	3	thought	think	VBN
cord-294366-swwz4kzd	57	4	that	that	IN
cord-294366-swwz4kzd	57	5	most	most	JJS
cord-294366-swwz4kzd	57	6	or	or	CC
cord-294366-swwz4kzd	57	7	all	all	DT
cord-294366-swwz4kzd	57	8	paraneoplastic	paraneoplastic	JJ
cord-294366-swwz4kzd	57	9	neurological	neurological	JJ
cord-294366-swwz4kzd	57	10	disorders	disorder	NNS
cord-294366-swwz4kzd	57	11	(	(	-LRB-
cord-294366-swwz4kzd	57	12	neurological	neurological	JJ
cord-294366-swwz4kzd	57	13	disorders	disorder	NNS
cord-294366-swwz4kzd	57	14	remote	remote	JJ
cord-294366-swwz4kzd	57	15	from	from	IN
cord-294366-swwz4kzd	57	16	the	the	DT
cord-294366-swwz4kzd	57	17	site	site	NN
cord-294366-swwz4kzd	57	18	of	of	IN
cord-294366-swwz4kzd	57	19	a	a	DT
cord-294366-swwz4kzd	57	20	malignant	malignant	JJ
cord-294366-swwz4kzd	57	21	neoplasm	neoplasm	NN
cord-294366-swwz4kzd	57	22	or	or	CC
cord-294366-swwz4kzd	57	23	its	-PRON-	PRP$
cord-294366-swwz4kzd	57	24	metastases	metastasis	NNS
cord-294366-swwz4kzd	57	25	)	)	-RRB-
cord-294366-swwz4kzd	57	26	are	be	VBP
cord-294366-swwz4kzd	57	27	immune	immune	JJ
cord-294366-swwz4kzd	57	28	mediated	mediate	VBN
cord-294366-swwz4kzd	57	29	[	[	-LRB-
cord-294366-swwz4kzd	57	30	22	22	CD
cord-294366-swwz4kzd	57	31	]	]	-RRB-
cord-294366-swwz4kzd	57	32	and	and	CC
cord-294366-swwz4kzd	57	33	this	this	DT
cord-294366-swwz4kzd	57	34	has	have	VBZ
cord-294366-swwz4kzd	57	35	been	be	VBN
cord-294366-swwz4kzd	57	36	cited	cite	VBN
cord-294366-swwz4kzd	57	37	as	as	IN
cord-294366-swwz4kzd	57	38	evidence	evidence	NN
cord-294366-swwz4kzd	57	39	for	for	IN
cord-294366-swwz4kzd	57	40	the	the	DT
cord-294366-swwz4kzd	57	41	involvement	involvement	NN
cord-294366-swwz4kzd	57	42	of	of	IN
cord-294366-swwz4kzd	57	43	specific	specific	JJ
cord-294366-swwz4kzd	57	44	immune	immune	JJ
cord-294366-swwz4kzd	57	45	responses	response	NNS
cord-294366-swwz4kzd	57	46	in	in	IN
cord-294366-swwz4kzd	57	47	cancer	cancer	NN
cord-294366-swwz4kzd	57	48	suppression	suppression	NN
cord-294366-swwz4kzd	57	49	[	[	-LRB-
cord-294366-swwz4kzd	57	50	23	23	CD
cord-294366-swwz4kzd	57	51	]	]	-RRB-
cord-294366-swwz4kzd	57	52	.	.	.
cord-294366-swwz4kzd	58	1	Indeed	indeed	RB
cord-294366-swwz4kzd	58	2	,	,	,
cord-294366-swwz4kzd	58	3	failure	failure	NN
cord-294366-swwz4kzd	58	4	to	to	TO
cord-294366-swwz4kzd	58	5	find	find	VB
cord-294366-swwz4kzd	58	6	the	the	DT
cord-294366-swwz4kzd	58	7	relevant	relevant	JJ
cord-294366-swwz4kzd	58	8	antigen	antigen	NN
cord-294366-swwz4kzd	58	9	in	in	IN
cord-294366-swwz4kzd	58	10	the	the	DT
cord-294366-swwz4kzd	58	11	cancer	cancer	NN
cord-294366-swwz4kzd	58	12	of	of	IN
cord-294366-swwz4kzd	58	13	a	a	DT
cord-294366-swwz4kzd	58	14	patient	patient	NN
cord-294366-swwz4kzd	58	15	should	should	MD
cord-294366-swwz4kzd	58	16	prompt	prompt	VB
cord-294366-swwz4kzd	58	17	a	a	DT
cord-294366-swwz4kzd	58	18	search	search	NN
cord-294366-swwz4kzd	58	19	for	for	IN
cord-294366-swwz4kzd	58	20	a	a	DT
cord-294366-swwz4kzd	58	21	second	second	JJ
cord-294366-swwz4kzd	58	22	cancer	cancer	NN
cord-294366-swwz4kzd	58	23	www.drugdiscoverytoday.com	www.drugdiscoverytoday.com	ADD
cord-294366-swwz4kzd	58	24	[	[	-LRB-
cord-294366-swwz4kzd	58	25	24	24	CD
cord-294366-swwz4kzd	58	26	]	]	-RRB-
cord-294366-swwz4kzd	58	27	.	.	.
cord-294366-swwz4kzd	59	1	Immunotherapy	immunotherapy	NN
cord-294366-swwz4kzd	59	2	has	have	VBZ
cord-294366-swwz4kzd	59	3	recently	recently	RB
cord-294366-swwz4kzd	59	4	achieved	achieve	VBN
cord-294366-swwz4kzd	59	5	much	much	JJ
cord-294366-swwz4kzd	59	6	interest	interest	NN
cord-294366-swwz4kzd	59	7	as	as	IN
cord-294366-swwz4kzd	59	8	a	a	DT
cord-294366-swwz4kzd	59	9	possible	possible	JJ
cord-294366-swwz4kzd	59	10	addition	addition	NN
cord-294366-swwz4kzd	59	11	to	to	IN
cord-294366-swwz4kzd	59	12	chemotherapeutic	chemotherapeutic	JJ
cord-294366-swwz4kzd	59	13	treatment	treatment	NN
cord-294366-swwz4kzd	59	14	[	[	-LRB-
cord-294366-swwz4kzd	59	15	25	25	CD
cord-294366-swwz4kzd	59	16	]	]	-RRB-
cord-294366-swwz4kzd	59	17	and	and	CC
cord-294366-swwz4kzd	59	18	this	this	DT
cord-294366-swwz4kzd	59	19	could	could	MD
cord-294366-swwz4kzd	59	20	open	open	VB
cord-294366-swwz4kzd	59	21	up	up	RP
cord-294366-swwz4kzd	59	22	a	a	DT
cord-294366-swwz4kzd	59	23	new	new	JJ
cord-294366-swwz4kzd	59	24	and	and	CC
cord-294366-swwz4kzd	59	25	innovative	innovative	JJ
cord-294366-swwz4kzd	59	26	avenue	avenue	NN
cord-294366-swwz4kzd	59	27	for	for	IN
cord-294366-swwz4kzd	59	28	clinical	clinical	JJ
cord-294366-swwz4kzd	59	29	trials	trial	NNS
cord-294366-swwz4kzd	59	30	.	.	.
cord-294366-swwz4kzd	60	1	Effective	effective	JJ
cord-294366-swwz4kzd	60	2	chemotherapy	chemotherapy	NN
cord-294366-swwz4kzd	60	3	against	against	IN
cord-294366-swwz4kzd	60	4	Schistosoma	Schistosoma	NNP
cord-294366-swwz4kzd	60	5	mansoni	mansoni	NNP
cord-294366-swwz4kzd	60	6	with	with	IN
cord-294366-swwz4kzd	60	7	praziquantel	praziquantel	NN
cord-294366-swwz4kzd	60	8	is	be	VBZ
cord-294366-swwz4kzd	60	9	dependent	dependent	JJ
cord-294366-swwz4kzd	60	10	on	on	IN
cord-294366-swwz4kzd	60	11	the	the	DT
cord-294366-swwz4kzd	60	12	presence	presence	NN
cord-294366-swwz4kzd	60	13	of	of	IN
cord-294366-swwz4kzd	60	14	antibodies	antibody	NNS
cord-294366-swwz4kzd	60	15	recognizing	recognize	VBG
cord-294366-swwz4kzd	60	16	schistosome	schistosome	NNP
cord-294366-swwz4kzd	60	17	glycoprotein	glycoprotein	NN
cord-294366-swwz4kzd	60	18	epitopes	epitope	NNS
cord-294366-swwz4kzd	60	19	[	[	-LRB-
cord-294366-swwz4kzd	60	20	26	26	CD
cord-294366-swwz4kzd	60	21	]	]	-RRB-
cord-294366-swwz4kzd	60	22	.	.	.
cord-294366-swwz4kzd	61	1	Another	another	DT
cord-294366-swwz4kzd	61	2	interesting	interesting	JJ
cord-294366-swwz4kzd	61	3	approach	approach	NN
cord-294366-swwz4kzd	61	4	is	be	VBZ
cord-294366-swwz4kzd	61	5	the	the	DT
cord-294366-swwz4kzd	61	6	therapeutic	therapeutic	JJ
cord-294366-swwz4kzd	61	7	vaccination	vaccination	NN
cord-294366-swwz4kzd	61	8	against	against	IN
cord-294366-swwz4kzd	61	9	cancer	cancer	NN
cord-294366-swwz4kzd	61	10	by	by	IN
cord-294366-swwz4kzd	61	11	targeting	target	VBG
cord-294366-swwz4kzd	61	12	anti	anti	JJ
cord-294366-swwz4kzd	61	13	-	-	JJ
cord-294366-swwz4kzd	61	14	apoptotic	apoptotic	JJ
cord-294366-swwz4kzd	61	15	molecules	molecule	NNS
cord-294366-swwz4kzd	61	16	[	[	-LRB-
cord-294366-swwz4kzd	61	17	27	27	CD
cord-294366-swwz4kzd	61	18	]	]	-RRB-
cord-294366-swwz4kzd	61	19	.	.	.
cord-294366-swwz4kzd	62	1	Infectious	infectious	JJ
cord-294366-swwz4kzd	62	2	agents	agent	NNS
cord-294366-swwz4kzd	62	3	are	be	VBP
cord-294366-swwz4kzd	62	4	implicated	implicate	VBN
cord-294366-swwz4kzd	62	5	as	as	IN
cord-294366-swwz4kzd	62	6	causes	cause	NNS
cord-294366-swwz4kzd	62	7	of	of	IN
cord-294366-swwz4kzd	62	8	cancer	cancer	NN
cord-294366-swwz4kzd	62	9	and	and	CC
cord-294366-swwz4kzd	62	10	contribute	contribute	VB
cord-294366-swwz4kzd	62	11	to	to	IN
cord-294366-swwz4kzd	62	12	a	a	DT
cord-294366-swwz4kzd	62	13	variety	variety	NN
cord-294366-swwz4kzd	62	14	of	of	IN
cord-294366-swwz4kzd	62	15	malignancies	malignancy	NNS
cord-294366-swwz4kzd	62	16	worldwide	worldwide	RB
cord-294366-swwz4kzd	62	17	.	.	.
cord-294366-swwz4kzd	63	1	Some	some	DT
cord-294366-swwz4kzd	63	2	of	of	IN
cord-294366-swwz4kzd	63	3	the	the	DT
cord-294366-swwz4kzd	63	4	major	major	JJ
cord-294366-swwz4kzd	63	5	players	player	NNS
cord-294366-swwz4kzd	63	6	in	in	IN
cord-294366-swwz4kzd	63	7	this	this	DT
cord-294366-swwz4kzd	63	8	role	role	NN
cord-294366-swwz4kzd	63	9	are	be	VBP
cord-294366-swwz4kzd	63	10	shown	show	VBN
cord-294366-swwz4kzd	63	11	in	in	IN
cord-294366-swwz4kzd	63	12	Table	Table	NNP
cord-294366-swwz4kzd	63	13	1	1	CD
cord-294366-swwz4kzd	63	14	and	and	CC
cord-294366-swwz4kzd	63	15	they	-PRON-	PRP
cord-294366-swwz4kzd	63	16	account	account	VBP
cord-294366-swwz4kzd	63	17	for	for	IN
cord-294366-swwz4kzd	63	18	several	several	JJ
cord-294366-swwz4kzd	63	19	of	of	IN
cord-294366-swwz4kzd	63	20	the	the	DT
cord-294366-swwz4kzd	63	21	most	most	RBS
cord-294366-swwz4kzd	63	22	common	common	JJ
cord-294366-swwz4kzd	63	23	malignancies	malignancy	NNS
cord-294366-swwz4kzd	63	24	and	and	CC
cord-294366-swwz4kzd	63	25	up	up	IN
cord-294366-swwz4kzd	63	26	to	to	TO
cord-294366-swwz4kzd	63	27	20	20	CD
cord-294366-swwz4kzd	63	28	%	%	NN
cord-294366-swwz4kzd	63	29	of	of	IN
cord-294366-swwz4kzd	63	30	malignancies	malignancy	NNS
cord-294366-swwz4kzd	63	31	around	around	IN
cord-294366-swwz4kzd	63	32	the	the	DT
cord-294366-swwz4kzd	63	33	globe	globe	NN
cord-294366-swwz4kzd	63	34	[	[	-LRB-
cord-294366-swwz4kzd	63	35	28	28	CD
cord-294366-swwz4kzd	63	36	]	]	-RRB-
cord-294366-swwz4kzd	63	37	.	.	.
cord-294366-swwz4kzd	64	1	As	as	IN
cord-294366-swwz4kzd	64	2	such	such	JJ
cord-294366-swwz4kzd	64	3	,	,	,
cord-294366-swwz4kzd	64	4	these	these	DT
cord-294366-swwz4kzd	64	5	agents	agent	NNS
cord-294366-swwz4kzd	64	6	offer	offer	VBP
cord-294366-swwz4kzd	64	7	increased	increase	VBN
cord-294366-swwz4kzd	64	8	potential	potential	NN
cord-294366-swwz4kzd	64	9	for	for	IN
cord-294366-swwz4kzd	64	10	prevention	prevention	NN
cord-294366-swwz4kzd	64	11	of	of	IN
cord-294366-swwz4kzd	64	12	cancer	cancer	NN
cord-294366-swwz4kzd	64	13	by	by	IN
cord-294366-swwz4kzd	64	14	prophylactic	prophylactic	JJ
cord-294366-swwz4kzd	64	15	vaccination	vaccination	NN
cord-294366-swwz4kzd	64	16	.	.	.
cord-294366-swwz4kzd	65	1	Administration	Administration	NNP
cord-294366-swwz4kzd	65	2	of	of	IN
cord-294366-swwz4kzd	65	3	antisera	antisera	NNP
cord-294366-swwz4kzd	65	4	as	as	IN
cord-294366-swwz4kzd	65	5	a	a	DT
cord-294366-swwz4kzd	65	6	treatment	treatment	NN
cord-294366-swwz4kzd	65	7	against	against	IN
cord-294366-swwz4kzd	65	8	snake	snake	NN
cord-294366-swwz4kzd	65	9	venom	venom	NN
cord-294366-swwz4kzd	65	10	dates	date	VBZ
cord-294366-swwz4kzd	65	11	back	back	RB
cord-294366-swwz4kzd	65	12	to	to	IN
cord-294366-swwz4kzd	65	13	the	the	DT
cord-294366-swwz4kzd	65	14	1890s	1890	NNS
cord-294366-swwz4kzd	65	15	and	and	CC
cord-294366-swwz4kzd	65	16	the	the	DT
cord-294366-swwz4kzd	65	17	work	work	NN
cord-294366-swwz4kzd	65	18	of	of	IN
cord-294366-swwz4kzd	65	19	Albert	Albert	NNP
cord-294366-swwz4kzd	65	20	Calmette	Calmette	NNP
cord-294366-swwz4kzd	65	21	.	.	.
cord-294366-swwz4kzd	66	1	Although	although	IN
cord-294366-swwz4kzd	66	2	this	this	DT
cord-294366-swwz4kzd	66	3	article	article	NN
cord-294366-swwz4kzd	66	4	largely	largely	RB
cord-294366-swwz4kzd	66	5	focuses	focus	VBZ
cord-294366-swwz4kzd	66	6	on	on	IN
cord-294366-swwz4kzd	66	7	active	active	JJ
cord-294366-swwz4kzd	66	8	immunisation	immunisation	NN
cord-294366-swwz4kzd	66	9	and	and	CC
cord-294366-swwz4kzd	66	10	the	the	DT
cord-294366-swwz4kzd	66	11	generation	generation	NN
cord-294366-swwz4kzd	66	12	of	of	IN
cord-294366-swwz4kzd	66	13	host	host	NN
cord-294366-swwz4kzd	66	14	antibodies	antibody	NNS
cord-294366-swwz4kzd	66	15	by	by	IN
cord-294366-swwz4kzd	66	16	the	the	DT
cord-294366-swwz4kzd	66	17	host	host	NN
cord-294366-swwz4kzd	66	18	immune	immune	JJ
cord-294366-swwz4kzd	66	19	system	system	NN
cord-294366-swwz4kzd	66	20	itself	-PRON-	PRP
cord-294366-swwz4kzd	66	21	,	,	,
cord-294366-swwz4kzd	66	22	the	the	DT
cord-294366-swwz4kzd	66	23	strategy	strategy	NN
cord-294366-swwz4kzd	66	24	of	of	IN
cord-294366-swwz4kzd	66	25	passive	passive	JJ
cord-294366-swwz4kzd	66	26	immunisation	immunisation	NN
cord-294366-swwz4kzd	66	27	is	be	VBZ
cord-294366-swwz4kzd	66	28	worth	worth	JJ
cord-294366-swwz4kzd	66	29	consideration	consideration	NN
cord-294366-swwz4kzd	66	30	,	,	,
cord-294366-swwz4kzd	66	31	as	as	IN
cord-294366-swwz4kzd	66	32	epitopes	epitope	NNS
cord-294366-swwz4kzd	66	33	identified	identify	VBN
cord-294366-swwz4kzd	66	34	using	use	VBG
cord-294366-swwz4kzd	66	35	modern	modern	JJ
cord-294366-swwz4kzd	66	36	molecular	molecular	JJ
cord-294366-swwz4kzd	66	37	biology	biology	NN
cord-294366-swwz4kzd	66	38	techniques	technique	NNS
cord-294366-swwz4kzd	66	39	might	may	MD
cord-294366-swwz4kzd	66	40	be	be	VB
cord-294366-swwz4kzd	66	41	targeted	target	VBN
cord-294366-swwz4kzd	66	42	by	by	IN
cord-294366-swwz4kzd	66	43	the	the	DT
cord-294366-swwz4kzd	66	44	use	use	NN
cord-294366-swwz4kzd	66	45	of	of	IN
cord-294366-swwz4kzd	66	46	passively	passively	RB
cord-294366-swwz4kzd	66	47	administered	administer	VBN
cord-294366-swwz4kzd	66	48	monoclonal	monoclonal	JJ
cord-294366-swwz4kzd	66	49	antibodies	antibody	NNS
cord-294366-swwz4kzd	66	50	.	.	.
cord-294366-swwz4kzd	67	1	Examples	example	NNS
cord-294366-swwz4kzd	67	2	of	of	IN
cord-294366-swwz4kzd	67	3	immunotherapy	immunotherapy	NN
cord-294366-swwz4kzd	67	4	using	use	VBG
cord-294366-swwz4kzd	67	5	monoclonal	monoclonal	JJ
cord-294366-swwz4kzd	67	6	antibodies	antibody	NNS
cord-294366-swwz4kzd	67	7	are	be	VBP
cord-294366-swwz4kzd	67	8	Campath	Campath	NNP
cord-294366-swwz4kzd	67	9	®	®	.
cord-294366-swwz4kzd	67	10	(	(	-LRB-
cord-294366-swwz4kzd	67	11	alemtuzumab	alemtuzumab	NNP
cord-294366-swwz4kzd	67	12	)	)	-RRB-
cord-294366-swwz4kzd	67	13	,	,	,
cord-294366-swwz4kzd	67	14	manufactured	manufacture	VBN
cord-294366-swwz4kzd	67	15	by	by	IN
cord-294366-swwz4kzd	67	16	Genzyme	Genzyme	NNP
cord-294366-swwz4kzd	67	17	for	for	IN
cord-294366-swwz4kzd	67	18	the	the	DT
cord-294366-swwz4kzd	67	19	treatment	treatment	NN
cord-294366-swwz4kzd	67	20	of	of	IN
cord-294366-swwz4kzd	67	21	B	b	NN
cord-294366-swwz4kzd	67	22	-	-	HYPH
cord-294366-swwz4kzd	67	23	cell	cell	NN
cord-294366-swwz4kzd	67	24	chronic	chronic	NN
cord-294366-swwz4kzd	67	25	lymphocytic	lymphocytic	JJ
cord-294366-swwz4kzd	67	26	leukaemia	leukaemia	NN
cord-294366-swwz4kzd	67	27	,	,	,
cord-294366-swwz4kzd	67	28	and	and	CC
cord-294366-swwz4kzd	67	29	Rituxan	Rituxan	NNP
cord-294366-swwz4kzd	67	30	®	®	.
cord-294366-swwz4kzd	67	31	(	(	-LRB-
cord-294366-swwz4kzd	67	32	Rituximab	Rituximab	NNP
cord-294366-swwz4kzd	67	33	)	)	-RRB-
cord-294366-swwz4kzd	67	34	,	,	,
cord-294366-swwz4kzd	67	35	a	a	DT
cord-294366-swwz4kzd	67	36	chimeric	chimeric	JJ
cord-294366-swwz4kzd	67	37	murine	murine	JJ
cord-294366-swwz4kzd	67	38	-	-	HYPH
cord-294366-swwz4kzd	67	39	human	human	JJ
cord-294366-swwz4kzd	67	40	monoclonal	monoclonal	JJ
cord-294366-swwz4kzd	67	41	antibody	antibody	NN
cord-294366-swwz4kzd	67	42	that	that	WDT
cord-294366-swwz4kzd	67	43	targets	target	VBZ
cord-294366-swwz4kzd	67	44	the	the	DT
cord-294366-swwz4kzd	67	45	CD20	CD20	NNP
cord-294366-swwz4kzd	67	46	antigen	antigen	NN
cord-294366-swwz4kzd	67	47	found	find	VBN
cord-294366-swwz4kzd	67	48	on	on	IN
cord-294366-swwz4kzd	67	49	the	the	DT
cord-294366-swwz4kzd	67	50	surface	surface	NN
cord-294366-swwz4kzd	67	51	of	of	IN
cord-294366-swwz4kzd	67	52	normal	normal	JJ
cord-294366-swwz4kzd	67	53	and	and	CC
cord-294366-swwz4kzd	67	54	malignant	malignant	JJ
cord-294366-swwz4kzd	67	55	B	b	NN
cord-294366-swwz4kzd	67	56	lymphocytes	lymphocyte	NNS
cord-294366-swwz4kzd	67	57	and	and	CC
cord-294366-swwz4kzd	67	58	used	use	VBN
cord-294366-swwz4kzd	67	59	in	in	IN
cord-294366-swwz4kzd	67	60	the	the	DT
cord-294366-swwz4kzd	67	61	treatment	treatment	NN
cord-294366-swwz4kzd	67	62	of	of	IN
cord-294366-swwz4kzd	67	63	non	non	JJ
cord-294366-swwz4kzd	67	64	-	-	JJ
cord-294366-swwz4kzd	67	65	Hodgkin	Hodgkin	NNP
cord-294366-swwz4kzd	67	66	's	's	POS
cord-294366-swwz4kzd	67	67	lymphoma	lymphoma	NN
cord-294366-swwz4kzd	67	68	.	.	.
cord-294366-swwz4kzd	68	1	This	this	DT
cord-294366-swwz4kzd	68	2	strategy	strategy	NN
cord-294366-swwz4kzd	68	3	is	be	VBZ
cord-294366-swwz4kzd	68	4	not	not	RB
cord-294366-swwz4kzd	68	5	restricted	restrict	VBN
cord-294366-swwz4kzd	68	6	to	to	IN
cord-294366-swwz4kzd	68	7	cancers	cancer	NNS
cord-294366-swwz4kzd	68	8	;	;	:
cord-294366-swwz4kzd	68	9	for	for	IN
cord-294366-swwz4kzd	68	10	example	example	NN
cord-294366-swwz4kzd	68	11	Remicade	Remicade	NNP
cord-294366-swwz4kzd	68	12	®	®	NNP
cord-294366-swwz4kzd	68	13	,	,	,
cord-294366-swwz4kzd	68	14	a	a	DT
cord-294366-swwz4kzd	68	15	chimeric	chimeric	JJ
cord-294366-swwz4kzd	68	16	monoclonal	monoclonal	JJ
cord-294366-swwz4kzd	68	17	antibody	antibody	NN
cord-294366-swwz4kzd	68	18	specific	specific	JJ
cord-294366-swwz4kzd	68	19	for	for	IN
cord-294366-swwz4kzd	68	20	tumour	tumour	NN
cord-294366-swwz4kzd	68	21	necrosis	necrosis	NN
cord-294366-swwz4kzd	68	22	factor	factor	NN
cord-294366-swwz4kzd	68	23	α	α	NNP
cord-294366-swwz4kzd	68	24	(	(	-LRB-
cord-294366-swwz4kzd	68	25	TNF	TNF	NNP
cord-294366-swwz4kzd	68	26	-	-	HYPH
cord-294366-swwz4kzd	68	27	α	α	NNP
cord-294366-swwz4kzd	68	28	,	,	,
cord-294366-swwz4kzd	68	29	is	be	VBZ
cord-294366-swwz4kzd	68	30	used	use	VBN
cord-294366-swwz4kzd	68	31	in	in	IN
cord-294366-swwz4kzd	68	32	the	the	DT
cord-294366-swwz4kzd	68	33	treatment	treatment	NN
cord-294366-swwz4kzd	68	34	of	of	IN
cord-294366-swwz4kzd	68	35	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	68	36	disease	disease	NN
cord-294366-swwz4kzd	68	37	.	.	.
cord-294366-swwz4kzd	69	1	The	the	DT
cord-294366-swwz4kzd	69	2	implementation	implementation	NN
cord-294366-swwz4kzd	69	3	of	of	IN
cord-294366-swwz4kzd	69	4	rational	rational	JJ
cord-294366-swwz4kzd	69	5	design	design	NN
cord-294366-swwz4kzd	69	6	was	be	VBD
cord-294366-swwz4kzd	69	7	first	first	RB
cord-294366-swwz4kzd	69	8	evident	evident	JJ
cord-294366-swwz4kzd	69	9	when	when	WRB
cord-294366-swwz4kzd	69	10	Pasteur	Pasteur	NNP
cord-294366-swwz4kzd	69	11	reproducibly	reproducibly	RB
cord-294366-swwz4kzd	69	12	manufactured	manufacture	VBD
cord-294366-swwz4kzd	69	13	attenuated	attenuated	JJ
cord-294366-swwz4kzd	69	14	cultures	culture	NNS
cord-294366-swwz4kzd	69	15	of	of	IN
cord-294366-swwz4kzd	69	16	chicken	chicken	NN
cord-294366-swwz4kzd	69	17	cholera	cholera	NN
cord-294366-swwz4kzd	69	18	vaccines	vaccine	NNS
cord-294366-swwz4kzd	69	19	,	,	,
cord-294366-swwz4kzd	69	20	thereby	thereby	RB
cord-294366-swwz4kzd	69	21	routinely	routinely	RB
cord-294366-swwz4kzd	69	22	preventing	prevent	VBG
cord-294366-swwz4kzd	69	23	cholera	cholera	NN
cord-294366-swwz4kzd	69	24	in	in	IN
cord-294366-swwz4kzd	69	25	vaccinated	vaccinated	JJ
cord-294366-swwz4kzd	69	26	chickens	chicken	NNS
cord-294366-swwz4kzd	69	27	.	.	.
cord-294366-swwz4kzd	70	1	Extrapolation	extrapolation	NN
cord-294366-swwz4kzd	70	2	of	of	IN
cord-294366-swwz4kzd	70	3	this	this	DT
cord-294366-swwz4kzd	70	4	strategy	strategy	NN
cord-294366-swwz4kzd	70	5	for	for	IN
cord-294366-swwz4kzd	70	6	anthrax	anthrax	NN
cord-294366-swwz4kzd	70	7	vaccines	vaccine	NNS
cord-294366-swwz4kzd	70	8	in	in	IN
cord-294366-swwz4kzd	70	9	livestock	livestock	NN
cord-294366-swwz4kzd	70	10	in	in	IN
cord-294366-swwz4kzd	70	11	the	the	DT
cord-294366-swwz4kzd	70	12	1880s	1880s	CD
cord-294366-swwz4kzd	70	13	was	be	VBD
cord-294366-swwz4kzd	70	14	a	a	DT
cord-294366-swwz4kzd	70	15	success	success	NN
cord-294366-swwz4kzd	70	16	with	with	IN
cord-294366-swwz4kzd	70	17	significant	significant	JJ
cord-294366-swwz4kzd	70	18	economic	economic	JJ
cord-294366-swwz4kzd	70	19	benefits	benefit	NNS
cord-294366-swwz4kzd	70	20	.	.	.
cord-294366-swwz4kzd	71	1	Despite	despite	IN
cord-294366-swwz4kzd	71	2	the	the	DT
cord-294366-swwz4kzd	71	3	elucidation	elucidation	NN
cord-294366-swwz4kzd	71	4	of	of	IN
cord-294366-swwz4kzd	71	5	an	an	DT
cord-294366-swwz4kzd	71	6	attenuated	attenuated	JJ
cord-294366-swwz4kzd	71	7	vaccination	vaccination	NN
cord-294366-swwz4kzd	71	8	strategy	strategy	NN
cord-294366-swwz4kzd	71	9	against	against	IN
cord-294366-swwz4kzd	71	10	rabies	rabie	NNS
cord-294366-swwz4kzd	71	11	and	and	CC
cord-294366-swwz4kzd	71	12	other	other	JJ
cord-294366-swwz4kzd	71	13	inactivated	inactivate	VBN
cord-294366-swwz4kzd	71	14	whole	whole	JJ
cord-294366-swwz4kzd	71	15	-	-	HYPH
cord-294366-swwz4kzd	71	16	organism	organism	NN
cord-294366-swwz4kzd	71	17	vaccines	vaccine	NNS
cord-294366-swwz4kzd	71	18	towards	towards	IN
cord-294366-swwz4kzd	71	19	the	the	DT
cord-294366-swwz4kzd	71	20	end	end	NN
cord-294366-swwz4kzd	71	21	of	of	IN
cord-294366-swwz4kzd	71	22	the	the	DT
cord-294366-swwz4kzd	71	23	nineteenth	nineteenth	JJ
cord-294366-swwz4kzd	71	24	century	century	NN
cord-294366-swwz4kzd	71	25	,	,	,
cord-294366-swwz4kzd	71	26	it	-PRON-	PRP
cord-294366-swwz4kzd	71	27	was	be	VBD
cord-294366-swwz4kzd	71	28	n't	not	RB
cord-294366-swwz4kzd	71	29	until	until	IN
cord-294366-swwz4kzd	71	30	the	the	DT
cord-294366-swwz4kzd	71	31	cell	cell	NN
cord-294366-swwz4kzd	71	32	-	-	HYPH
cord-294366-swwz4kzd	71	33	culture	culture	NN
cord-294366-swwz4kzd	71	34	revolution	revolution	NN
cord-294366-swwz4kzd	71	35	in	in	IN
cord-294366-swwz4kzd	71	36	1950	1950	CD
cord-294366-swwz4kzd	71	37	-	-	SYM
cord-294366-swwz4kzd	71	38	1980	1980	CD
cord-294366-swwz4kzd	71	39	that	that	WDT
cord-294366-swwz4kzd	71	40	attenuated	attenuate	VBD
cord-294366-swwz4kzd	71	41	viral	viral	JJ
cord-294366-swwz4kzd	71	42	vaccines	vaccine	NNS
cord-294366-swwz4kzd	71	43	really	really	RB
cord-294366-swwz4kzd	71	44	took	take	VBD
cord-294366-swwz4kzd	71	45	off	off	RP
cord-294366-swwz4kzd	71	46	,	,	,
cord-294366-swwz4kzd	71	47	together	together	RB
cord-294366-swwz4kzd	71	48	with	with	IN
cord-294366-swwz4kzd	71	49	the	the	DT
cord-294366-swwz4kzd	71	50	isolation	isolation	NN
cord-294366-swwz4kzd	71	51	and	and	CC
cord-294366-swwz4kzd	71	52	use	use	NN
cord-294366-swwz4kzd	71	53	of	of	IN
cord-294366-swwz4kzd	71	54	extracts	extract	NNS
cord-294366-swwz4kzd	71	55	and	and	CC
cord-294366-swwz4kzd	71	56	subunits	subunit	NNS
cord-294366-swwz4kzd	71	57	of	of	IN
cord-294366-swwz4kzd	71	58	infectious	infectious	JJ
cord-294366-swwz4kzd	71	59	agents	agent	NNS
cord-294366-swwz4kzd	71	60	.	.	.
cord-294366-swwz4kzd	72	1	Pasteur	Pasteur	NNP
cord-294366-swwz4kzd	72	2	's	's	POS
cord-294366-swwz4kzd	72	3	approaches	approach	NNS
cord-294366-swwz4kzd	72	4	of	of	IN
cord-294366-swwz4kzd	72	5	attenuation	attenuation	NN
cord-294366-swwz4kzd	72	6	and	and	CC
cord-294366-swwz4kzd	72	7	inactivation	inactivation	NN
cord-294366-swwz4kzd	72	8	still	still	RB
cord-294366-swwz4kzd	72	9	today	today	NN
cord-294366-swwz4kzd	72	10	provide	provide	VB
cord-294366-swwz4kzd	72	11	the	the	DT
cord-294366-swwz4kzd	72	12	two	two	CD
cord-294366-swwz4kzd	72	13	poles	pole	NNS
cord-294366-swwz4kzd	72	14	of	of	IN
cord-294366-swwz4kzd	72	15	vaccine	vaccine	NN
cord-294366-swwz4kzd	72	16	technology	technology	NN
cord-294366-swwz4kzd	72	17	[	[	-LRB-
cord-294366-swwz4kzd	72	18	29	29	CD
cord-294366-swwz4kzd	72	19	]	]	-RRB-
cord-294366-swwz4kzd	72	20	.	.	.
cord-294366-swwz4kzd	73	1	A	a	DT
cord-294366-swwz4kzd	73	2	chronology	chronology	NN
cord-294366-swwz4kzd	73	3	of	of	IN
cord-294366-swwz4kzd	73	4	important	important	JJ
cord-294366-swwz4kzd	73	5	developments	development	NNS
cord-294366-swwz4kzd	73	6	and	and	CC
cord-294366-swwz4kzd	73	7	achievements	achievement	NNS
cord-294366-swwz4kzd	73	8	in	in	IN
cord-294366-swwz4kzd	73	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	73	10	research	research	NN
cord-294366-swwz4kzd	73	11	and	and	CC
cord-294366-swwz4kzd	73	12	implementation	implementation	NN
cord-294366-swwz4kzd	73	13	is	be	VBZ
cord-294366-swwz4kzd	73	14	shown	show	VBN
cord-294366-swwz4kzd	73	15	in	in	IN
cord-294366-swwz4kzd	73	16	Figure	figure	NN
cord-294366-swwz4kzd	73	17	1	1	CD
cord-294366-swwz4kzd	73	18	.	.	.
cord-294366-swwz4kzd	74	1	Recent	recent	JJ
cord-294366-swwz4kzd	74	2	developments	development	NNS
cord-294366-swwz4kzd	74	3	in	in	IN
cord-294366-swwz4kzd	74	4	vaccine	vaccine	NN
cord-294366-swwz4kzd	74	5	technology	technology	NN
cord-294366-swwz4kzd	74	6	and	and	CC
cord-294366-swwz4kzd	74	7	application	application	NN
cord-294366-swwz4kzd	74	8	include	include	VBP
cord-294366-swwz4kzd	74	9	combination	combination	NN
cord-294366-swwz4kzd	74	10	vaccines	vaccine	NNS
cord-294366-swwz4kzd	74	11	,	,	,
cord-294366-swwz4kzd	74	12	new	new	JJ
cord-294366-swwz4kzd	74	13	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	74	14	and	and	CC
cord-294366-swwz4kzd	74	15	delivery	delivery	NN
cord-294366-swwz4kzd	74	16	systems	system	NNS
cord-294366-swwz4kzd	74	17	,	,	,
cord-294366-swwz4kzd	74	18	reverse	reverse	VB
cord-294366-swwz4kzd	74	19	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	74	20	and	and	CC
cord-294366-swwz4kzd	74	21	vaccines	vaccine	NNS
cord-294366-swwz4kzd	74	22	against	against	IN
cord-294366-swwz4kzd	74	23	noninfectious	noninfectious	JJ
cord-294366-swwz4kzd	74	24	diseases	disease	NNS
cord-294366-swwz4kzd	74	25	.	.	.
cord-294366-swwz4kzd	75	1	The	the	DT
cord-294366-swwz4kzd	75	2	history	history	NN
cord-294366-swwz4kzd	75	3	of	of	IN
cord-294366-swwz4kzd	75	4	vaccine	vaccine	NN
cord-294366-swwz4kzd	75	5	development	development	NN
cord-294366-swwz4kzd	75	6	is	be	VBZ
cord-294366-swwz4kzd	75	7	very	very	RB
cord-294366-swwz4kzd	75	8	much	much	RB
cord-294366-swwz4kzd	75	9	related	relate	VBN
cord-294366-swwz4kzd	75	10	to	to	IN
cord-294366-swwz4kzd	75	11	technological	technological	JJ
cord-294366-swwz4kzd	75	12	advances	advance	NNS
cord-294366-swwz4kzd	75	13	[	[	-LRB-
cord-294366-swwz4kzd	75	14	30	30	CD
cord-294366-swwz4kzd	75	15	]	]	-RRB-
cord-294366-swwz4kzd	75	16	.	.	.
cord-294366-swwz4kzd	76	1	Subunit	subunit	NN
cord-294366-swwz4kzd	76	2	vaccines	vaccine	NNS
cord-294366-swwz4kzd	76	3	can	can	MD
cord-294366-swwz4kzd	76	4	be	be	VB
cord-294366-swwz4kzd	76	5	produced	produce	VBN
cord-294366-swwz4kzd	76	6	in	in	IN
cord-294366-swwz4kzd	76	7	bulk	bulk	NN
cord-294366-swwz4kzd	76	8	,	,	,
cord-294366-swwz4kzd	76	9	safely	safely	RB
cord-294366-swwz4kzd	76	10	and	and	CC
cord-294366-swwz4kzd	76	11	reproducibly	reproducibly	RB
cord-294366-swwz4kzd	76	12	,	,	,
cord-294366-swwz4kzd	76	13	using	use	VBG
cord-294366-swwz4kzd	76	14	recombinant	recombinant	JJ
cord-294366-swwz4kzd	76	15	DNA	dna	NN
cord-294366-swwz4kzd	76	16	technology	technology	NN
cord-294366-swwz4kzd	76	17	.	.	.
cord-294366-swwz4kzd	77	1	Much	much	JJ
cord-294366-swwz4kzd	77	2	research	research	NN
cord-294366-swwz4kzd	77	3	has	have	VBZ
cord-294366-swwz4kzd	77	4	already	already	RB
cord-294366-swwz4kzd	77	5	been	be	VBN
cord-294366-swwz4kzd	77	6	accomplished	accomplish	VBN
cord-294366-swwz4kzd	77	7	in	in	IN
cord-294366-swwz4kzd	77	8	the	the	DT
cord-294366-swwz4kzd	77	9	development	development	NN
cord-294366-swwz4kzd	77	10	of	of	IN
cord-294366-swwz4kzd	77	11	suitable	suitable	JJ
cord-294366-swwz4kzd	77	12	carrier	carrier	NN
cord-294366-swwz4kzd	77	13	systems	system	NNS
cord-294366-swwz4kzd	77	14	able	able	JJ
cord-294366-swwz4kzd	77	15	to	to	TO
cord-294366-swwz4kzd	77	16	engender	engender	VB
cord-294366-swwz4kzd	77	17	enhanced	enhanced	JJ
cord-294366-swwz4kzd	77	18	immune	immune	JJ
cord-294366-swwz4kzd	77	19	responses	response	NNS
cord-294366-swwz4kzd	77	20	to	to	IN
cord-294366-swwz4kzd	77	21	entrapped	entrap	VBN
cord-294366-swwz4kzd	77	22	peptide	peptide	NN
cord-294366-swwz4kzd	77	23	and	and	CC
cord-294366-swwz4kzd	77	24	protein	protein	NN
cord-294366-swwz4kzd	77	25	epitopes	epitope	NNS
cord-294366-swwz4kzd	77	26	.	.	.
cord-294366-swwz4kzd	78	1	The	the	DT
cord-294366-swwz4kzd	78	2	identification	identification	NN
cord-294366-swwz4kzd	78	3	of	of	IN
cord-294366-swwz4kzd	78	4	potentially	potentially	RB
cord-294366-swwz4kzd	78	5	useful	useful	JJ
cord-294366-swwz4kzd	78	6	antigens	antigen	NNS
cord-294366-swwz4kzd	78	7	is	be	VBZ
cord-294366-swwz4kzd	78	8	greatly	greatly	RB
cord-294366-swwz4kzd	78	9	facilitated	facilitate	VBN
cord-294366-swwz4kzd	78	10	by	by	IN
cord-294366-swwz4kzd	78	11	improved	improve	VBN
cord-294366-swwz4kzd	78	12	molecular	molecular	JJ
cord-294366-swwz4kzd	78	13	biology	biology	NN
cord-294366-swwz4kzd	78	14	techniques	technique	NNS
cord-294366-swwz4kzd	78	15	,	,	,
cord-294366-swwz4kzd	78	16	such	such	JJ
cord-294366-swwz4kzd	78	17	as	as	IN
cord-294366-swwz4kzd	78	18	microarray	microarray	NN
cord-294366-swwz4kzd	78	19	technology	technology	NN
cord-294366-swwz4kzd	78	20	(	(	-LRB-
cord-294366-swwz4kzd	78	21	discussed	discuss	VBN
cord-294366-swwz4kzd	78	22	further	further	RB
cord-294366-swwz4kzd	78	23	below	below	RB
cord-294366-swwz4kzd	78	24	)	)	-RRB-
cord-294366-swwz4kzd	78	25	,	,	,
cord-294366-swwz4kzd	78	26	but	but	CC
cord-294366-swwz4kzd	78	27	the	the	DT
cord-294366-swwz4kzd	78	28	elucidation	elucidation	NN
cord-294366-swwz4kzd	78	29	of	of	IN
cord-294366-swwz4kzd	78	30	their	-PRON-	PRP$
cord-294366-swwz4kzd	78	31	full	full	JJ
cord-294366-swwz4kzd	78	32	potential	potential	NN
cord-294366-swwz4kzd	78	33	might	may	MD
cord-294366-swwz4kzd	78	34	rely	rely	VB
cord-294366-swwz4kzd	78	35	on	on	IN
cord-294366-swwz4kzd	78	36	the	the	DT
cord-294366-swwz4kzd	78	37	development	development	NN
cord-294366-swwz4kzd	78	38	of	of	IN
cord-294366-swwz4kzd	78	39	effective	effective	JJ
cord-294366-swwz4kzd	78	40	delivery	delivery	NN
cord-294366-swwz4kzd	78	41	systems	system	NNS
cord-294366-swwz4kzd	78	42	and	and	CC
cord-294366-swwz4kzd	78	43	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	78	44	.	.	.
cord-294366-swwz4kzd	79	1	Many	many	JJ
cord-294366-swwz4kzd	79	2	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	79	3	are	be	VBP
cord-294366-swwz4kzd	79	4	based	base	VBN
cord-294366-swwz4kzd	79	5	on	on	IN
cord-294366-swwz4kzd	79	6	microbial	microbial	JJ
cord-294366-swwz4kzd	79	7	components	component	NNS
cord-294366-swwz4kzd	79	8	but	but	CC
cord-294366-swwz4kzd	79	9	others	other	NNS
cord-294366-swwz4kzd	79	10	,	,	,
cord-294366-swwz4kzd	79	11	traditionally	traditionally	RB
cord-294366-swwz4kzd	79	12	aluminium	aluminium	VBP
cord-294366-swwz4kzd	79	13	salts	salt	NNS
cord-294366-swwz4kzd	79	14	and	and	CC
cord-294366-swwz4kzd	79	15	more	more	JJR
cord-294366-swwz4kzd	79	16	recently	recently	RB
cord-294366-swwz4kzd	79	17	emulsions	emulsion	NNS
cord-294366-swwz4kzd	79	18	and	and	CC
cord-294366-swwz4kzd	79	19	surfactant	surfactant	NN
cord-294366-swwz4kzd	79	20	based	base	VBN
cord-294366-swwz4kzd	79	21	formulations	formulation	NNS
cord-294366-swwz4kzd	79	22	,	,	,
cord-294366-swwz4kzd	79	23	exploit	exploit	VB
cord-294366-swwz4kzd	79	24	different	different	JJ
cord-294366-swwz4kzd	79	25	mechanisms	mechanism	NNS
cord-294366-swwz4kzd	79	26	of	of	IN
cord-294366-swwz4kzd	79	27	action	action	NN
cord-294366-swwz4kzd	79	28	.	.	.
cord-294366-swwz4kzd	80	1	Particulate	particulate	NN
cord-294366-swwz4kzd	80	2	delivery	delivery	NN
cord-294366-swwz4kzd	80	3	can	can	MD
cord-294366-swwz4kzd	80	4	be	be	VB
cord-294366-swwz4kzd	80	5	mediated	mediate	VBN
cord-294366-swwz4kzd	80	6	by	by	IN
cord-294366-swwz4kzd	80	7	polymer	polymer	NN
cord-294366-swwz4kzd	80	8	[	[	-LRB-
cord-294366-swwz4kzd	80	9	often	often	RB
cord-294366-swwz4kzd	80	10	poli(lactideco	poli(lactideco	NN
cord-294366-swwz4kzd	80	11	-	-	HYPH
cord-294366-swwz4kzd	80	12	glycolide	glycolide	NN
cord-294366-swwz4kzd	80	13	)	)	-RRB-
cord-294366-swwz4kzd	80	14	]	]	-RRB-
cord-294366-swwz4kzd	80	15	microparticles	microparticle	NNS
cord-294366-swwz4kzd	80	16	,	,	,
cord-294366-swwz4kzd	80	17	immunostimulatory	immunostimulatory	NNP
cord-294366-swwz4kzd	80	18	complexes	complex	NNS
cord-294366-swwz4kzd	80	19	,	,	,
cord-294366-swwz4kzd	80	20	liposomes	liposome	NNS
cord-294366-swwz4kzd	80	21	and	and	CC
cord-294366-swwz4kzd	80	22	virosomes	virosome	NNS
cord-294366-swwz4kzd	80	23	[	[	-LRB-
cord-294366-swwz4kzd	80	24	31	31	CD
cord-294366-swwz4kzd	80	25	]	]	-RRB-
cord-294366-swwz4kzd	80	26	.	.	.
cord-294366-swwz4kzd	81	1	Possible	possible	JJ
cord-294366-swwz4kzd	81	2	advantages	advantage	NNS
cord-294366-swwz4kzd	81	3	of	of	IN
cord-294366-swwz4kzd	81	4	particulate	particulate	NN
cord-294366-swwz4kzd	81	5	delivery	delivery	NN
cord-294366-swwz4kzd	81	6	are	be	VBP
cord-294366-swwz4kzd	81	7	that	that	IN
cord-294366-swwz4kzd	81	8	antigen	antigen	NN
cord-294366-swwz4kzd	81	9	and	and	CC
cord-294366-swwz4kzd	81	10	coadjuvant	coadjuvant	NN
cord-294366-swwz4kzd	81	11	can	can	MD
cord-294366-swwz4kzd	81	12	be	be	VB
cord-294366-swwz4kzd	81	13	delivered	deliver	VBN
cord-294366-swwz4kzd	81	14	to	to	IN
cord-294366-swwz4kzd	81	15	the	the	DT
cord-294366-swwz4kzd	81	16	same	same	JJ
cord-294366-swwz4kzd	81	17	cell	cell	NN
cord-294366-swwz4kzd	81	18	and	and	CC
cord-294366-swwz4kzd	81	19	particulates	particulate	NNS
cord-294366-swwz4kzd	81	20	have	have	VBP
cord-294366-swwz4kzd	81	21	excellent	excellent	JJ
cord-294366-swwz4kzd	81	22	potential	potential	NN
cord-294366-swwz4kzd	81	23	for	for	IN
cord-294366-swwz4kzd	81	24	targeting	target	VBG
cord-294366-swwz4kzd	81	25	cells	cell	NNS
cord-294366-swwz4kzd	81	26	of	of	IN
cord-294366-swwz4kzd	81	27	the	the	DT
cord-294366-swwz4kzd	81	28	immune	immune	JJ
cord-294366-swwz4kzd	81	29	system	system	NN
cord-294366-swwz4kzd	81	30	[	[	-LRB-
cord-294366-swwz4kzd	81	31	32	32	CD
cord-294366-swwz4kzd	81	32	]	]	-RRB-
cord-294366-swwz4kzd	81	33	.	.	.
cord-294366-swwz4kzd	82	1	The	the	DT
cord-294366-swwz4kzd	82	2	extensive	extensive	JJ
cord-294366-swwz4kzd	82	3	diversity	diversity	NN
cord-294366-swwz4kzd	82	4	of	of	IN
cord-294366-swwz4kzd	82	5	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	82	6	and	and	CC
cord-294366-swwz4kzd	82	7	delivery	delivery	NN
cord-294366-swwz4kzd	82	8	systems	system	NNS
cord-294366-swwz4kzd	82	9	is	be	VBZ
cord-294366-swwz4kzd	82	10	more	more	RBR
cord-294366-swwz4kzd	82	11	comprehensively	comprehensively	RB
cord-294366-swwz4kzd	82	12	reviewed	review	VBN
cord-294366-swwz4kzd	82	13	elsewhere	elsewhere	RB
cord-294366-swwz4kzd	82	14	[	[	-LRB-
cord-294366-swwz4kzd	82	15	31	31	CD
cord-294366-swwz4kzd	82	16	]	]	-RRB-
cord-294366-swwz4kzd	83	1	[	[	-LRB-
cord-294366-swwz4kzd	83	2	32	32	CD
cord-294366-swwz4kzd	83	3	]	]	-RRB-
cord-294366-swwz4kzd	83	4	[	[	-LRB-
cord-294366-swwz4kzd	83	5	33	33	CD
cord-294366-swwz4kzd	83	6	]	]	-RRB-
cord-294366-swwz4kzd	84	1	[	[	-LRB-
cord-294366-swwz4kzd	84	2	34	34	CD
cord-294366-swwz4kzd	84	3	]	]	-RRB-
cord-294366-swwz4kzd	84	4	and	and	CC
cord-294366-swwz4kzd	84	5	this	this	DT
cord-294366-swwz4kzd	84	6	review	review	NN
cord-294366-swwz4kzd	84	7	will	will	MD
cord-294366-swwz4kzd	84	8	,	,	,
cord-294366-swwz4kzd	84	9	where	where	WRB
cord-294366-swwz4kzd	84	10	appropriate	appropriate	JJ
cord-294366-swwz4kzd	84	11	,	,	,
cord-294366-swwz4kzd	84	12	focus	focus	VB
cord-294366-swwz4kzd	84	13	on	on	IN
cord-294366-swwz4kzd	84	14	the	the	DT
cord-294366-swwz4kzd	84	15	application	application	NN
cord-294366-swwz4kzd	84	16	and	and	CC
cord-294366-swwz4kzd	84	17	other	other	JJ
cord-294366-swwz4kzd	84	18	aspects	aspect	NNS
cord-294366-swwz4kzd	84	19	of	of	IN
cord-294366-swwz4kzd	84	20	this	this	DT
cord-294366-swwz4kzd	84	21	technology	technology	NN
cord-294366-swwz4kzd	84	22	.	.	.
cord-294366-swwz4kzd	85	1	The	the	DT
cord-294366-swwz4kzd	85	2	300	300	CD
cord-294366-swwz4kzd	85	3	million	million	CD
cord-294366-swwz4kzd	85	4	doses	dose	NNS
cord-294366-swwz4kzd	85	5	of	of	IN
cord-294366-swwz4kzd	85	6	influenza	influenza	NN
cord-294366-swwz4kzd	85	7	vaccine	vaccine	NN
cord-294366-swwz4kzd	85	8	needed	need	VBN
cord-294366-swwz4kzd	85	9	annually	annually	RB
cord-294366-swwz4kzd	85	10	worldwide	worldwide	RB
cord-294366-swwz4kzd	85	11	require	require	VBP
cord-294366-swwz4kzd	85	12	more	more	JJR
cord-294366-swwz4kzd	85	13	than	than	IN
cord-294366-swwz4kzd	85	14	350	350	CD
cord-294366-swwz4kzd	85	15	million	million	CD
cord-294366-swwz4kzd	85	16	chicken	chicken	NN
cord-294366-swwz4kzd	85	17	eggs	egg	NNS
cord-294366-swwz4kzd	85	18	and	and	CC
cord-294366-swwz4kzd	85	19	six	six	CD
cord-294366-swwz4kzd	85	20	or	or	CC
cord-294366-swwz4kzd	85	21	more	more	JJR
cord-294366-swwz4kzd	85	22	months	month	NNS
cord-294366-swwz4kzd	85	23	.	.	.
cord-294366-swwz4kzd	86	1	The	the	DT
cord-294366-swwz4kzd	86	2	development	development	NN
cord-294366-swwz4kzd	86	3	of	of	IN
cord-294366-swwz4kzd	86	4	cell	cell	NN
cord-294366-swwz4kzd	86	5	-	-	HYPH
cord-294366-swwz4kzd	86	6	culture	culture	NN
cord-294366-swwz4kzd	86	7	technology	technology	NN
cord-294366-swwz4kzd	86	8	that	that	WDT
cord-294366-swwz4kzd	86	9	could	could	MD
cord-294366-swwz4kzd	86	10	replace	replace	VB
cord-294366-swwz4kzd	86	11	the	the	DT
cord-294366-swwz4kzd	86	12	egg	egg	NN
cord-294366-swwz4kzd	86	13	-	-	HYPH
cord-294366-swwz4kzd	86	14	based	base	VBN
cord-294366-swwz4kzd	86	15	manufacturing	manufacturing	NN
cord-294366-swwz4kzd	86	16	process	process	NN
cord-294366-swwz4kzd	86	17	might	may	MD
cord-294366-swwz4kzd	86	18	facilitate	facilitate	VB
cord-294366-swwz4kzd	86	19	faster	fast	JJR
cord-294366-swwz4kzd	86	20	production	production	NN
cord-294366-swwz4kzd	86	21	of	of	IN
cord-294366-swwz4kzd	86	22	much	much	JJ
cord-294366-swwz4kzd	86	23	-	-	HYPH
cord-294366-swwz4kzd	86	24	higher	high	JJR
cord-294366-swwz4kzd	86	25	antigen	antigen	NN
cord-294366-swwz4kzd	86	26	yields	yield	NNS
cord-294366-swwz4kzd	86	27	[	[	-LRB-
cord-294366-swwz4kzd	86	28	4	4	CD
cord-294366-swwz4kzd	86	29	]	]	-RRB-
cord-294366-swwz4kzd	86	30	.	.	.
cord-294366-swwz4kzd	87	1	Live	live	JJ
cord-294366-swwz4kzd	87	2	vaccines	vaccine	NNS
cord-294366-swwz4kzd	87	3	generally	generally	RB
cord-294366-swwz4kzd	87	4	possess	possess	VBP
cord-294366-swwz4kzd	87	5	a	a	DT
cord-294366-swwz4kzd	87	6	natural	natural	JJ
cord-294366-swwz4kzd	87	7	adjuvant	adjuvant	NN
cord-294366-swwz4kzd	87	8	capability	capability	NN
cord-294366-swwz4kzd	87	9	that	that	WDT
cord-294366-swwz4kzd	87	10	is	be	VBZ
cord-294366-swwz4kzd	87	11	built	build	VBN
cord-294366-swwz4kzd	87	12	on	on	IN
cord-294366-swwz4kzd	87	13	the	the	DT
cord-294366-swwz4kzd	87	14	evolved	evolved	JJ
cord-294366-swwz4kzd	87	15	ability	ability	NN
cord-294366-swwz4kzd	87	16	of	of	IN
cord-294366-swwz4kzd	87	17	our	-PRON-	PRP$
cord-294366-swwz4kzd	87	18	immune	immune	JJ
cord-294366-swwz4kzd	87	19	system	system	NN
cord-294366-swwz4kzd	87	20	to	to	TO
cord-294366-swwz4kzd	87	21	recognize	recognize	VB
cord-294366-swwz4kzd	87	22	many	many	JJ
cord-294366-swwz4kzd	87	23	facets	facet	NNS
cord-294366-swwz4kzd	87	24	of	of	IN
cord-294366-swwz4kzd	87	25	potentially	potentially	RB
cord-294366-swwz4kzd	87	26	dangerous	dangerous	JJ
cord-294366-swwz4kzd	87	27	microbes	microbe	NNS
cord-294366-swwz4kzd	87	28	and	and	CC
cord-294366-swwz4kzd	87	29	they	-PRON-	PRP
cord-294366-swwz4kzd	87	30	have	have	VBP
cord-294366-swwz4kzd	87	31	contributed	contribute	VBN
cord-294366-swwz4kzd	87	32	immeasurably	immeasurably	RB
cord-294366-swwz4kzd	87	33	to	to	IN
cord-294366-swwz4kzd	87	34	the	the	DT
cord-294366-swwz4kzd	87	35	control	control	NN
cord-294366-swwz4kzd	87	36	of	of	IN
cord-294366-swwz4kzd	87	37	disease	disease	NN
cord-294366-swwz4kzd	87	38	.	.	.
cord-294366-swwz4kzd	88	1	Although	although	IN
cord-294366-swwz4kzd	88	2	some	some	DT
cord-294366-swwz4kzd	88	3	live	live	JJ
cord-294366-swwz4kzd	88	4	vaccines	vaccine	NNS
cord-294366-swwz4kzd	88	5	might	may	MD
cord-294366-swwz4kzd	88	6	have	have	VB
cord-294366-swwz4kzd	88	7	undesirable	undesirable	JJ
cord-294366-swwz4kzd	88	8	characteristics	characteristic	NNS
cord-294366-swwz4kzd	88	9	,	,	,
cord-294366-swwz4kzd	88	10	such	such	JJ
cord-294366-swwz4kzd	88	11	as	as	IN
cord-294366-swwz4kzd	88	12	the	the	DT
cord-294366-swwz4kzd	88	13	mutation	mutation	NN
cord-294366-swwz4kzd	88	14	of	of	IN
cord-294366-swwz4kzd	88	15	polio	polio	NNP
cord-294366-swwz4kzd	88	16	virus	virus	NN
cord-294366-swwz4kzd	88	17	and	and	CC
cord-294366-swwz4kzd	88	18	persistence	persistence	NN
cord-294366-swwz4kzd	88	19	of	of	IN
cord-294366-swwz4kzd	88	20	viruses	virus	NNS
cord-294366-swwz4kzd	88	21	such	such	JJ
cord-294366-swwz4kzd	88	22	as	as	IN
cord-294366-swwz4kzd	88	23	varicella	varicella	NN
cord-294366-swwz4kzd	88	24	zoster	zoster	NNP
cord-294366-swwz4kzd	88	25	virus	virus	NN
cord-294366-swwz4kzd	88	26	,	,	,
cord-294366-swwz4kzd	88	27	their	-PRON-	PRP$
cord-294366-swwz4kzd	88	28	use	use	NN
cord-294366-swwz4kzd	88	29	has	have	VBZ
cord-294366-swwz4kzd	88	30	been	be	VBN
cord-294366-swwz4kzd	88	31	,	,	,
cord-294366-swwz4kzd	88	32	and	and	CC
cord-294366-swwz4kzd	88	33	indeed	indeed	RB
cord-294366-swwz4kzd	88	34	remains	remain	VBZ
cord-294366-swwz4kzd	88	35	,	,	,
cord-294366-swwz4kzd	88	36	able	able	JJ
cord-294366-swwz4kzd	88	37	to	to	TO
cord-294366-swwz4kzd	88	38	significantly	significantly	RB
cord-294366-swwz4kzd	88	39	reduce	reduce	VB
cord-294366-swwz4kzd	88	40	the	the	DT
cord-294366-swwz4kzd	88	41	impact	impact	NN
cord-294366-swwz4kzd	88	42	of	of	IN
cord-294366-swwz4kzd	88	43	associated	associated	JJ
cord-294366-swwz4kzd	88	44	diseases	disease	NNS
cord-294366-swwz4kzd	88	45	[	[	-LRB-
cord-294366-swwz4kzd	88	46	35	35	CD
cord-294366-swwz4kzd	88	47	,	,	,
cord-294366-swwz4kzd	88	48	36	36	CD
cord-294366-swwz4kzd	88	49	]	]	-RRB-
cord-294366-swwz4kzd	88	50	.	.	.
cord-294366-swwz4kzd	89	1	Viruses	virus	NNS
cord-294366-swwz4kzd	89	2	and	and	CC
cord-294366-swwz4kzd	89	3	bacteria	bacteria	NNS
cord-294366-swwz4kzd	89	4	as	as	IN
cord-294366-swwz4kzd	89	5	carriers	carrier	NNS
cord-294366-swwz4kzd	89	6	of	of	IN
cord-294366-swwz4kzd	89	7	heterologous	heterologous	JJ
cord-294366-swwz4kzd	89	8	antigens	antigen	NNS
cord-294366-swwz4kzd	89	9	and	and	CC
cord-294366-swwz4kzd	89	10	genes	gene	NNS
cord-294366-swwz4kzd	89	11	have	have	VBP
cord-294366-swwz4kzd	89	12	received	receive	VBN
cord-294366-swwz4kzd	89	13	considerable	considerable	JJ
cord-294366-swwz4kzd	89	14	attention	attention	NN
cord-294366-swwz4kzd	89	15	over	over	IN
cord-294366-swwz4kzd	89	16	previous	previous	JJ
cord-294366-swwz4kzd	89	17	decades	decade	NNS
cord-294366-swwz4kzd	89	18	,	,	,
cord-294366-swwz4kzd	89	19	and	and	CC
cord-294366-swwz4kzd	89	20	generation	generation	NN
cord-294366-swwz4kzd	89	21	of	of	IN
cord-294366-swwz4kzd	89	22	auxotrophic	auxotrophic	JJ
cord-294366-swwz4kzd	89	23	mutants	mutant	NNS
cord-294366-swwz4kzd	89	24	,	,	,
cord-294366-swwz4kzd	89	25	as	as	RB
cord-294366-swwz4kzd	89	26	well	well	RB
cord-294366-swwz4kzd	89	27	as	as	IN
cord-294366-swwz4kzd	89	28	the	the	DT
cord-294366-swwz4kzd	89	29	use	use	NN
cord-294366-swwz4kzd	89	30	of	of	IN
cord-294366-swwz4kzd	89	31	other	other	JJ
cord-294366-swwz4kzd	89	32	replication	replication	NN
cord-294366-swwz4kzd	89	33	incompetent	incompetent	JJ
cord-294366-swwz4kzd	89	34	vectors	vector	NNS
cord-294366-swwz4kzd	89	35	and	and	CC
cord-294366-swwz4kzd	89	36	of	of	IN
cord-294366-swwz4kzd	89	37	reassortant	reassortant	JJ
cord-294366-swwz4kzd	89	38	viruses	virus	NNS
cord-294366-swwz4kzd	89	39	generated	generate	VBN
cord-294366-swwz4kzd	89	40	by	by	IN
cord-294366-swwz4kzd	89	41	the	the	DT
cord-294366-swwz4kzd	89	42	addition	addition	NN
cord-294366-swwz4kzd	89	43	of	of	IN
cord-294366-swwz4kzd	89	44	RNA	RNA	NNP
cord-294366-swwz4kzd	89	45	segments	segment	NNS
cord-294366-swwz4kzd	89	46	to	to	IN
cord-294366-swwz4kzd	89	47	viruses	virus	NNS
cord-294366-swwz4kzd	89	48	with	with	IN
cord-294366-swwz4kzd	89	49	segmented	segmented	JJ
cord-294366-swwz4kzd	89	50	genomes	genome	NNS
cord-294366-swwz4kzd	89	51	,	,	,
cord-294366-swwz4kzd	89	52	such	such	JJ
cord-294366-swwz4kzd	89	53	as	as	IN
cord-294366-swwz4kzd	89	54	influenza	influenza	NN
cord-294366-swwz4kzd	89	55	and	and	CC
cord-294366-swwz4kzd	89	56	rotavirus	rotavirus	NN
cord-294366-swwz4kzd	89	57	,	,	,
cord-294366-swwz4kzd	89	58	indicates	indicate	VBZ
cord-294366-swwz4kzd	89	59	the	the	DT
cord-294366-swwz4kzd	89	60	potential	potential	JJ
cord-294366-swwz4kzd	89	61	inherent	inherent	NN
cord-294366-swwz4kzd	89	62	in	in	IN
cord-294366-swwz4kzd	89	63	these	these	DT
cord-294366-swwz4kzd	89	64	efficient	efficient	JJ
cord-294366-swwz4kzd	89	65	types	type	NNS
cord-294366-swwz4kzd	89	66	of	of	IN
cord-294366-swwz4kzd	89	67	vaccine	vaccine	NN
cord-294366-swwz4kzd	89	68	.	.	.
cord-294366-swwz4kzd	90	1	In	in	IN
cord-294366-swwz4kzd	90	2	an	an	DT
cord-294366-swwz4kzd	90	3	interesting	interesting	JJ
cord-294366-swwz4kzd	90	4	utilization	utilization	NN
cord-294366-swwz4kzd	90	5	of	of	IN
cord-294366-swwz4kzd	90	6	viral	viral	JJ
cord-294366-swwz4kzd	90	7	replication	replication	NN
cord-294366-swwz4kzd	90	8	,	,	,
cord-294366-swwz4kzd	90	9	a	a	DT
cord-294366-swwz4kzd	90	10	self	self	NN
cord-294366-swwz4kzd	90	11	-	-	HYPH
cord-294366-swwz4kzd	90	12	replicating	replicate	VBG
cord-294366-swwz4kzd	90	13	RNA	RNA	NNP
cord-294366-swwz4kzd	90	14	vector	vector	NN
cord-294366-swwz4kzd	90	15	encoding	encode	VBG
cord-294366-swwz4kzd	90	16	a	a	DT
cord-294366-swwz4kzd	90	17	model	model	NN
cord-294366-swwz4kzd	90	18	antigen	antigen	NN
cord-294366-swwz4kzd	90	19	(	(	-LRB-
cord-294366-swwz4kzd	90	20	β	β	NN
cord-294366-swwz4kzd	90	21	-	-	HYPH
cord-294366-swwz4kzd	90	22	gal	gal	NNP
cord-294366-swwz4kzd	90	23	)	)	-RRB-
cord-294366-swwz4kzd	90	24	,	,	,
cord-294366-swwz4kzd	90	25	which	which	WDT
cord-294366-swwz4kzd	90	26	was	be	VBD
cord-294366-swwz4kzd	90	27	shown	show	VBN
cord-294366-swwz4kzd	90	28	to	to	TO
cord-294366-swwz4kzd	90	29	protect	protect	VB
cord-294366-swwz4kzd	90	30	mice	mouse	NNS
cord-294366-swwz4kzd	90	31	against	against	IN
cord-294366-swwz4kzd	90	32	subsequent	subsequent	JJ
cord-294366-swwz4kzd	90	33	tumour	tumour	NN
cord-294366-swwz4kzd	90	34	challenge	challenge	NN
cord-294366-swwz4kzd	90	35	with	with	IN
cord-294366-swwz4kzd	90	36	colon	colon	NN
cord-294366-swwz4kzd	90	37	carcinoma	carcinoma	NN
cord-294366-swwz4kzd	90	38	cells	cell	NNS
cord-294366-swwz4kzd	90	39	engineered	engineer	VBN
cord-294366-swwz4kzd	90	40	to	to	TO
cord-294366-swwz4kzd	90	41	express	express	VB
cord-294366-swwz4kzd	90	42	β	β	NN
cord-294366-swwz4kzd	90	43	-	-	HYPH
cord-294366-swwz4kzd	90	44	gal	gal	NNP
cord-294366-swwz4kzd	90	45	,	,	,
cord-294366-swwz4kzd	90	46	was	be	VBD
cord-294366-swwz4kzd	90	47	also	also	RB
cord-294366-swwz4kzd	90	48	shown	show	VBN
cord-294366-swwz4kzd	90	49	to	to	TO
cord-294366-swwz4kzd	90	50	effectively	effectively	RB
cord-294366-swwz4kzd	90	51	induce	induce	VB
cord-294366-swwz4kzd	90	52	apoptosis	apoptosis	NN
cord-294366-swwz4kzd	90	53	in	in	IN
cord-294366-swwz4kzd	90	54	transduced	transduce	VBN
cord-294366-swwz4kzd	90	55	cells	cell	NNS
cord-294366-swwz4kzd	90	56	[	[	-LRB-
cord-294366-swwz4kzd	90	57	37	37	CD
cord-294366-swwz4kzd	90	58	]	]	-RRB-
cord-294366-swwz4kzd	90	59	.	.	.
cord-294366-swwz4kzd	91	1	The	the	DT
cord-294366-swwz4kzd	91	2	observed	observed	JJ
cord-294366-swwz4kzd	91	3	apoptosis	apoptosis	NN
cord-294366-swwz4kzd	91	4	also	also	RB
cord-294366-swwz4kzd	91	5	facilitated	facilitate	VBD
cord-294366-swwz4kzd	91	6	enhanced	enhanced	JJ
cord-294366-swwz4kzd	91	7	uptake	uptake	NN
cord-294366-swwz4kzd	91	8	by	by	IN
cord-294366-swwz4kzd	91	9	dendritic	dendritic	JJ
cord-294366-swwz4kzd	91	10	cells	cell	NNS
cord-294366-swwz4kzd	91	11	and	and	CC
cord-294366-swwz4kzd	91	12	was	be	VBD
cord-294366-swwz4kzd	91	13	likely	likely	RB
cord-294366-swwz4kzd	91	14	mediated	mediate	VBN
cord-294366-swwz4kzd	91	15	by	by	IN
cord-294366-swwz4kzd	91	16	the	the	DT
cord-294366-swwz4kzd	91	17	presence	presence	NN
cord-294366-swwz4kzd	91	18	of	of	IN
cord-294366-swwz4kzd	91	19	double	double	RB
cord-294366-swwz4kzd	91	20	-	-	HYPH
cord-294366-swwz4kzd	91	21	stranded	strand	VBN
cord-294366-swwz4kzd	91	22	RNA	RNA	NNP
cord-294366-swwz4kzd	91	23	in	in	IN
cord-294366-swwz4kzd	91	24	replication	replication	NN
cord-294366-swwz4kzd	91	25	of	of	IN
cord-294366-swwz4kzd	91	26	the	the	DT
cord-294366-swwz4kzd	91	27	virally	virally	RB
cord-294366-swwz4kzd	91	28	derived	derive	VBN
cord-294366-swwz4kzd	91	29	genome	genome	NN
cord-294366-swwz4kzd	91	30	.	.	.
cord-294366-swwz4kzd	92	1	Double	double	JJ
cord-294366-swwz4kzd	92	2	-	-	HYPH
cord-294366-swwz4kzd	92	3	stranded	strand	VBN
cord-294366-swwz4kzd	92	4	RNA	RNA	NNP
cord-294366-swwz4kzd	92	5	is	be	VBZ
cord-294366-swwz4kzd	92	6	recognized	recognize	VBN
cord-294366-swwz4kzd	92	7	by	by	IN
cord-294366-swwz4kzd	92	8	Toll	toll	NN
cord-294366-swwz4kzd	92	9	-	-	HYPH
cord-294366-swwz4kzd	92	10	like	like	JJ
cord-294366-swwz4kzd	92	11	receptor	receptor	NN
cord-294366-swwz4kzd	92	12	(	(	-LRB-
cord-294366-swwz4kzd	92	13	TLR	TLR	NNP
cord-294366-swwz4kzd	92	14	)	)	-RRB-
cord-294366-swwz4kzd	92	15	binding	binding	NN
cord-294366-swwz4kzd	92	16	.	.	.
cord-294366-swwz4kzd	93	1	Different	different	JJ
cord-294366-swwz4kzd	93	2	TLRs	tlr	NNS
cord-294366-swwz4kzd	93	3	recognize	recognize	VBP
cord-294366-swwz4kzd	93	4	different	different	JJ
cord-294366-swwz4kzd	93	5	surface	surface	NN
cord-294366-swwz4kzd	93	6	and	and	CC
cord-294366-swwz4kzd	93	7	intracellular	intracellular	JJ
cord-294366-swwz4kzd	93	8	components	component	NNS
cord-294366-swwz4kzd	93	9	of	of	IN
cord-294366-swwz4kzd	93	10	microorganisms	microorganism	NNS
cord-294366-swwz4kzd	93	11	.	.	.
cord-294366-swwz4kzd	94	1	The	the	DT
cord-294366-swwz4kzd	94	2	interaction	interaction	NN
cord-294366-swwz4kzd	94	3	between	between	IN
cord-294366-swwz4kzd	94	4	a	a	DT
cord-294366-swwz4kzd	94	5	TLR	TLR	NNP
cord-294366-swwz4kzd	94	6	and	and	CC
cord-294366-swwz4kzd	94	7	a	a	DT
cord-294366-swwz4kzd	94	8	microbial	microbial	JJ
cord-294366-swwz4kzd	94	9	component	component	NN
cord-294366-swwz4kzd	94	10	triggers	trigger	VBZ
cord-294366-swwz4kzd	94	11	the	the	DT
cord-294366-swwz4kzd	94	12	activation	activation	NN
cord-294366-swwz4kzd	94	13	of	of	IN
cord-294366-swwz4kzd	94	14	the	the	DT
cord-294366-swwz4kzd	94	15	innate	innate	JJ
cord-294366-swwz4kzd	94	16	immune	immune	JJ
cord-294366-swwz4kzd	94	17	system	system	NN
cord-294366-swwz4kzd	94	18	and	and	CC
cord-294366-swwz4kzd	94	19	www.drugdiscoverytoday.com	www.drugdiscoverytoday.com	ADD
cord-294366-swwz4kzd	95	1	the	the	DT
cord-294366-swwz4kzd	95	2	initiation	initiation	NN
cord-294366-swwz4kzd	95	3	of	of	IN
cord-294366-swwz4kzd	95	4	acquired	acquire	VBN
cord-294366-swwz4kzd	95	5	immunity	immunity	NN
cord-294366-swwz4kzd	95	6	[	[	-LRB-
cord-294366-swwz4kzd	95	7	38	38	CD
cord-294366-swwz4kzd	95	8	]	]	-RRB-
cord-294366-swwz4kzd	95	9	.	.	.
cord-294366-swwz4kzd	96	1	The	the	DT
cord-294366-swwz4kzd	96	2	elucidation	elucidation	NN
cord-294366-swwz4kzd	96	3	of	of	IN
cord-294366-swwz4kzd	96	4	these	these	DT
cord-294366-swwz4kzd	96	5	pathways	pathway	NNS
cord-294366-swwz4kzd	96	6	sheds	shed	VBZ
cord-294366-swwz4kzd	96	7	light	light	NN
cord-294366-swwz4kzd	96	8	on	on	IN
cord-294366-swwz4kzd	96	9	mechanisms	mechanism	NNS
cord-294366-swwz4kzd	96	10	of	of	IN
cord-294366-swwz4kzd	96	11	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	96	12	action	action	NN
cord-294366-swwz4kzd	96	13	and	and	CC
cord-294366-swwz4kzd	96	14	provides	provide	VBZ
cord-294366-swwz4kzd	96	15	a	a	DT
cord-294366-swwz4kzd	96	16	basis	basis	NN
cord-294366-swwz4kzd	96	17	for	for	IN
cord-294366-swwz4kzd	96	18	the	the	DT
cord-294366-swwz4kzd	96	19	inclusion	inclusion	NN
cord-294366-swwz4kzd	96	20	of	of	IN
cord-294366-swwz4kzd	96	21	such	such	JJ
cord-294366-swwz4kzd	96	22	potent	potent	JJ
cord-294366-swwz4kzd	96	23	agents	agent	NNS
cord-294366-swwz4kzd	96	24	and	and	CC
cord-294366-swwz4kzd	96	25	their	-PRON-	PRP$
cord-294366-swwz4kzd	96	26	analogues	analogue	NNS
cord-294366-swwz4kzd	96	27	in	in	IN
cord-294366-swwz4kzd	96	28	vaccine	vaccine	NN
cord-294366-swwz4kzd	96	29	design	design	NN
cord-294366-swwz4kzd	96	30	.	.	.
cord-294366-swwz4kzd	97	1	It	-PRON-	PRP
cord-294366-swwz4kzd	97	2	is	be	VBZ
cord-294366-swwz4kzd	97	3	important	important	JJ
cord-294366-swwz4kzd	97	4	to	to	TO
cord-294366-swwz4kzd	97	5	consider	consider	VB
cord-294366-swwz4kzd	97	6	how	how	WRB
cord-294366-swwz4kzd	97	7	we	-PRON-	PRP
cord-294366-swwz4kzd	97	8	classify	classify	VBP
cord-294366-swwz4kzd	97	9	or	or	CC
cord-294366-swwz4kzd	97	10	view	view	VB
cord-294366-swwz4kzd	97	11	rational	rational	JJ
cord-294366-swwz4kzd	97	12	design	design	NN
cord-294366-swwz4kzd	97	13	in	in	IN
cord-294366-swwz4kzd	97	14	the	the	DT
cord-294366-swwz4kzd	97	15	context	context	NN
cord-294366-swwz4kzd	97	16	of	of	IN
cord-294366-swwz4kzd	97	17	vaccines	vaccine	NNS
cord-294366-swwz4kzd	97	18	.	.	.
cord-294366-swwz4kzd	98	1	A	a	DT
cord-294366-swwz4kzd	98	2	picture	picture	NN
cord-294366-swwz4kzd	98	3	springs	spring	NNS
cord-294366-swwz4kzd	98	4	to	to	IN
cord-294366-swwz4kzd	98	5	mind	mind	NN
cord-294366-swwz4kzd	98	6	of	of	IN
cord-294366-swwz4kzd	98	7	the	the	DT
cord-294366-swwz4kzd	98	8	rapid	rapid	JJ
cord-294366-swwz4kzd	98	9	analysis	analysis	NN
cord-294366-swwz4kzd	98	10	of	of	IN
cord-294366-swwz4kzd	98	11	pathogens	pathogen	NNS
cord-294366-swwz4kzd	98	12	,	,	,
cord-294366-swwz4kzd	98	13	the	the	DT
cord-294366-swwz4kzd	98	14	identification	identification	NN
cord-294366-swwz4kzd	98	15	and	and	CC
cord-294366-swwz4kzd	98	16	allocation	allocation	NN
cord-294366-swwz4kzd	98	17	of	of	IN
cord-294366-swwz4kzd	98	18	immunological	immunological	JJ
cord-294366-swwz4kzd	98	19	interactions	interaction	NNS
cord-294366-swwz4kzd	98	20	for	for	IN
cord-294366-swwz4kzd	98	21	specific	specific	JJ
cord-294366-swwz4kzd	98	22	genes	gene	NNS
cord-294366-swwz4kzd	98	23	,	,	,
cord-294366-swwz4kzd	98	24	as	as	RB
cord-294366-swwz4kzd	98	25	well	well	RB
cord-294366-swwz4kzd	98	26	as	as	IN
cord-294366-swwz4kzd	98	27	the	the	DT
cord-294366-swwz4kzd	98	28	generation	generation	NN
cord-294366-swwz4kzd	98	29	of	of	IN
cord-294366-swwz4kzd	98	30	a	a	DT
cord-294366-swwz4kzd	98	31	superimposed	superimpose	VBN
cord-294366-swwz4kzd	98	32	choreography	choreography	NN
cord-294366-swwz4kzd	98	33	of	of	IN
cord-294366-swwz4kzd	98	34	the	the	DT
cord-294366-swwz4kzd	98	35	infection	infection	NN
cord-294366-swwz4kzd	98	36	or	or	CC
cord-294366-swwz4kzd	98	37	disease	disease	NN
cord-294366-swwz4kzd	98	38	process	process	NN
cord-294366-swwz4kzd	98	39	,	,	,
cord-294366-swwz4kzd	98	40	resulting	result	VBG
cord-294366-swwz4kzd	98	41	in	in	IN
cord-294366-swwz4kzd	98	42	the	the	DT
cord-294366-swwz4kzd	98	43	identification	identification	NN
cord-294366-swwz4kzd	98	44	of	of	IN
cord-294366-swwz4kzd	98	45	credible	credible	JJ
cord-294366-swwz4kzd	98	46	candidate	candidate	NN
cord-294366-swwz4kzd	98	47	target	target	NN
cord-294366-swwz4kzd	98	48	antigens	antigen	NNS
cord-294366-swwz4kzd	98	49	.	.	.
cord-294366-swwz4kzd	99	1	Following	follow	VBG
cord-294366-swwz4kzd	99	2	this	this	DT
cord-294366-swwz4kzd	99	3	,	,	,
cord-294366-swwz4kzd	99	4	appropriate	appropriate	JJ
cord-294366-swwz4kzd	99	5	formulation	formulation	NN
cord-294366-swwz4kzd	99	6	with	with	IN
cord-294366-swwz4kzd	99	7	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	99	8	and	and	CC
cord-294366-swwz4kzd	99	9	delivery	delivery	NN
cord-294366-swwz4kzd	99	10	systems	system	NNS
cord-294366-swwz4kzd	99	11	might	may	MD
cord-294366-swwz4kzd	99	12	elicit	elicit	VB
cord-294366-swwz4kzd	99	13	immune	immune	JJ
cord-294366-swwz4kzd	99	14	responses	response	NNS
cord-294366-swwz4kzd	99	15	of	of	IN
cord-294366-swwz4kzd	99	16	the	the	DT
cord-294366-swwz4kzd	99	17	type	type	NN
cord-294366-swwz4kzd	99	18	and	and	CC
cord-294366-swwz4kzd	99	19	magnitude	magnitude	NN
cord-294366-swwz4kzd	99	20	predictive	predictive	JJ
cord-294366-swwz4kzd	99	21	of	of	IN
cord-294366-swwz4kzd	99	22	providing	provide	VBG
cord-294366-swwz4kzd	99	23	protection	protection	NN
cord-294366-swwz4kzd	99	24	or	or	CC
cord-294366-swwz4kzd	99	25	therapeutic	therapeutic	JJ
cord-294366-swwz4kzd	99	26	action	action	NN
cord-294366-swwz4kzd	99	27	.	.	.
cord-294366-swwz4kzd	100	1	The	the	DT
cord-294366-swwz4kzd	100	2	truth	truth	NN
cord-294366-swwz4kzd	100	3	is	be	VBZ
cord-294366-swwz4kzd	100	4	that	that	IN
cord-294366-swwz4kzd	100	5	we	-PRON-	PRP
cord-294366-swwz4kzd	100	6	are	be	VBP
cord-294366-swwz4kzd	100	7	still	still	RB
cord-294366-swwz4kzd	100	8	very	very	RB
cord-294366-swwz4kzd	100	9	far	far	RB
cord-294366-swwz4kzd	100	10	from	from	IN
cord-294366-swwz4kzd	100	11	this	this	DT
cord-294366-swwz4kzd	100	12	idyll	idyll	NN
cord-294366-swwz4kzd	100	13	.	.	.
cord-294366-swwz4kzd	101	1	Recent	recent	JJ
cord-294366-swwz4kzd	101	2	articles	article	NNS
cord-294366-swwz4kzd	101	3	have	have	VBP
cord-294366-swwz4kzd	101	4	intimated	intimate	VBN
cord-294366-swwz4kzd	101	5	the	the	DT
cord-294366-swwz4kzd	101	6	minor	minor	JJ
cord-294366-swwz4kzd	101	7	contribution	contribution	NN
cord-294366-swwz4kzd	101	8	of	of	IN
cord-294366-swwz4kzd	101	9	our	-PRON-	PRP$
cord-294366-swwz4kzd	101	10	knowledge	knowledge	NN
cord-294366-swwz4kzd	101	11	of	of	IN
cord-294366-swwz4kzd	101	12	immunology	immunology	NN
cord-294366-swwz4kzd	101	13	to	to	IN
cord-294366-swwz4kzd	101	14	the	the	DT
cord-294366-swwz4kzd	101	15	development	development	NN
cord-294366-swwz4kzd	101	16	of	of	IN
cord-294366-swwz4kzd	101	17	vaccines	vaccine	NNS
cord-294366-swwz4kzd	101	18	[	[	-LRB-
cord-294366-swwz4kzd	101	19	39	39	CD
cord-294366-swwz4kzd	101	20	,	,	,
cord-294366-swwz4kzd	101	21	29	29	CD
cord-294366-swwz4kzd	101	22	]	]	-RRB-
cord-294366-swwz4kzd	101	23	.	.	.
cord-294366-swwz4kzd	102	1	However	however	RB
cord-294366-swwz4kzd	102	2	,	,	,
cord-294366-swwz4kzd	102	3	the	the	DT
cord-294366-swwz4kzd	102	4	development	development	NN
cord-294366-swwz4kzd	102	5	of	of	IN
cord-294366-swwz4kzd	102	6	improved	improved	JJ
cord-294366-swwz4kzd	102	7	and	and	CC
cord-294366-swwz4kzd	102	8	large	large	JJ
cord-294366-swwz4kzd	102	9	-	-	HYPH
cord-294366-swwz4kzd	102	10	scale	scale	NN
cord-294366-swwz4kzd	102	11	cellular	cellular	JJ
cord-294366-swwz4kzd	102	12	immunity	immunity	NN
cord-294366-swwz4kzd	102	13	techniques	technique	NNS
cord-294366-swwz4kzd	102	14	for	for	IN
cord-294366-swwz4kzd	102	15	the	the	DT
cord-294366-swwz4kzd	102	16	analysis	analysis	NN
cord-294366-swwz4kzd	102	17	of	of	IN
cord-294366-swwz4kzd	102	18	immune	immune	JJ
cord-294366-swwz4kzd	102	19	responses	response	NNS
cord-294366-swwz4kzd	102	20	,	,	,
cord-294366-swwz4kzd	102	21	such	such	JJ
cord-294366-swwz4kzd	102	22	as	as	IN
cord-294366-swwz4kzd	102	23	ELISPOT	ELISPOT	NNP
cord-294366-swwz4kzd	102	24	for	for	IN
cord-294366-swwz4kzd	102	25	cytokine	cytokine	NN
cord-294366-swwz4kzd	102	26	induction	induction	NN
cord-294366-swwz4kzd	102	27	,	,	,
cord-294366-swwz4kzd	102	28	tetramer	tetramer	NN
cord-294366-swwz4kzd	102	29	staining	staining	NN
cord-294366-swwz4kzd	102	30	for	for	IN
cord-294366-swwz4kzd	102	31	peptide	peptide	JJ
cord-294366-swwz4kzd	102	32	specific	specific	JJ
cord-294366-swwz4kzd	102	33	CTLs	ctl	NNS
cord-294366-swwz4kzd	102	34	,	,	,
cord-294366-swwz4kzd	102	35	along	along	IN
cord-294366-swwz4kzd	102	36	with	with	IN
cord-294366-swwz4kzd	102	37	analysis	analysis	NN
cord-294366-swwz4kzd	102	38	of	of	IN
cord-294366-swwz4kzd	102	39	the	the	DT
cord-294366-swwz4kzd	102	40	immunological	immunological	JJ
cord-294366-swwz4kzd	102	41	basis	basis	NN
cord-294366-swwz4kzd	102	42	for	for	IN
cord-294366-swwz4kzd	102	43	the	the	DT
cord-294366-swwz4kzd	102	44	efficacy	efficacy	NN
cord-294366-swwz4kzd	102	45	of	of	IN
cord-294366-swwz4kzd	102	46	successful	successful	JJ
cord-294366-swwz4kzd	102	47	vaccines	vaccine	NNS
cord-294366-swwz4kzd	102	48	,	,	,
cord-294366-swwz4kzd	102	49	facilitates	facilitate	VBZ
cord-294366-swwz4kzd	102	50	the	the	DT
cord-294366-swwz4kzd	102	51	role	role	NN
cord-294366-swwz4kzd	102	52	of	of	IN
cord-294366-swwz4kzd	102	53	immunology	immunology	NN
cord-294366-swwz4kzd	102	54	in	in	IN
cord-294366-swwz4kzd	102	55	predicting	predict	VBG
cord-294366-swwz4kzd	102	56	the	the	DT
cord-294366-swwz4kzd	102	57	appropriate	appropriate	JJ
cord-294366-swwz4kzd	102	58	context	context	NN
cord-294366-swwz4kzd	102	59	for	for	IN
cord-294366-swwz4kzd	102	60	antigen	antigen	NN
cord-294366-swwz4kzd	102	61	delivery	delivery	NN
cord-294366-swwz4kzd	102	62	.	.	.
cord-294366-swwz4kzd	103	1	Extensive	extensive	JJ
cord-294366-swwz4kzd	103	2	characterisation	characterisation	NN
cord-294366-swwz4kzd	103	3	of	of	IN
cord-294366-swwz4kzd	103	4	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	103	5	action	action	NN
cord-294366-swwz4kzd	103	6	and	and	CC
cord-294366-swwz4kzd	103	7	the	the	DT
cord-294366-swwz4kzd	103	8	potential	potential	NN
cord-294366-swwz4kzd	103	9	to	to	TO
cord-294366-swwz4kzd	103	10	target	target	VB
cord-294366-swwz4kzd	103	11	desired	desire	VBN
cord-294366-swwz4kzd	103	12	immune	immune	JJ
cord-294366-swwz4kzd	103	13	responses	response	NNS
cord-294366-swwz4kzd	103	14	through	through	IN
cord-294366-swwz4kzd	103	15	the	the	DT
cord-294366-swwz4kzd	103	16	exploitation	exploitation	NN
cord-294366-swwz4kzd	103	17	of	of	IN
cord-294366-swwz4kzd	103	18	this	this	DT
cord-294366-swwz4kzd	103	19	knowledge	knowledge	NN
cord-294366-swwz4kzd	103	20	is	be	VBZ
cord-294366-swwz4kzd	103	21	key	key	JJ
cord-294366-swwz4kzd	103	22	for	for	IN
cord-294366-swwz4kzd	103	23	rational	rational	JJ
cord-294366-swwz4kzd	103	24	vaccine	vaccine	NN
cord-294366-swwz4kzd	103	25	design	design	NN
cord-294366-swwz4kzd	103	26	[	[	-LRB-
cord-294366-swwz4kzd	103	27	29	29	CD
cord-294366-swwz4kzd	103	28	,	,	,
cord-294366-swwz4kzd	103	29	31	31	CD
cord-294366-swwz4kzd	103	30	,	,	,
cord-294366-swwz4kzd	103	31	32	32	CD
cord-294366-swwz4kzd	103	32	,	,	,
cord-294366-swwz4kzd	103	33	39	39	CD
cord-294366-swwz4kzd	103	34	,	,	,
cord-294366-swwz4kzd	103	35	40	40	CD
cord-294366-swwz4kzd	103	36	]	]	-RRB-
cord-294366-swwz4kzd	103	37	.	.	.
cord-294366-swwz4kzd	104	1	The	the	DT
cord-294366-swwz4kzd	104	2	interaction	interaction	NN
cord-294366-swwz4kzd	104	3	between	between	IN
cord-294366-swwz4kzd	104	4	different	different	JJ
cord-294366-swwz4kzd	104	5	elements	element	NNS
cord-294366-swwz4kzd	104	6	involved	involve	VBN
cord-294366-swwz4kzd	104	7	in	in	IN
cord-294366-swwz4kzd	104	8	rational	rational	JJ
cord-294366-swwz4kzd	104	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	104	10	design	design	NN
cord-294366-swwz4kzd	104	11	is	be	VBZ
cord-294366-swwz4kzd	104	12	outlined	outline	VBN
cord-294366-swwz4kzd	104	13	in	in	IN
cord-294366-swwz4kzd	104	14	Figure	figure	NN
cord-294366-swwz4kzd	104	15	2	2	CD
cord-294366-swwz4kzd	104	16	.	.	.
cord-294366-swwz4kzd	105	1	The	the	DT
cord-294366-swwz4kzd	105	2	use	use	NN
cord-294366-swwz4kzd	105	3	of	of	IN
cord-294366-swwz4kzd	105	4	microarray	microarray	NN
cord-294366-swwz4kzd	105	5	technology	technology	NN
cord-294366-swwz4kzd	105	6	can	can	MD
cord-294366-swwz4kzd	105	7	allow	allow	VB
cord-294366-swwz4kzd	105	8	identification	identification	NN
cord-294366-swwz4kzd	105	9	of	of	IN
cord-294366-swwz4kzd	105	10	virulence	virulence	NN
cord-294366-swwz4kzd	105	11	genes	gene	NNS
cord-294366-swwz4kzd	105	12	and	and	CC
cord-294366-swwz4kzd	105	13	vaccine	vaccine	NN
cord-294366-swwz4kzd	105	14	targets	target	NNS
cord-294366-swwz4kzd	105	15	[	[	-LRB-
cord-294366-swwz4kzd	105	16	41	41	CD
cord-294366-swwz4kzd	105	17	]	]	-RRB-
cord-294366-swwz4kzd	105	18	and	and	CC
cord-294366-swwz4kzd	105	19	is	be	VBZ
cord-294366-swwz4kzd	105	20	one	one	CD
cord-294366-swwz4kzd	105	21	of	of	IN
cord-294366-swwz4kzd	105	22	the	the	DT
cord-294366-swwz4kzd	105	23	most	most	RBS
cord-294366-swwz4kzd	105	24	powerful	powerful	JJ
cord-294366-swwz4kzd	105	25	tools	tool	NNS
cord-294366-swwz4kzd	105	26	for	for	IN
cord-294366-swwz4kzd	105	27	the	the	DT
cord-294366-swwz4kzd	105	28	study	study	NN
cord-294366-swwz4kzd	105	29	of	of	IN
cord-294366-swwz4kzd	105	30	the	the	DT
cord-294366-swwz4kzd	105	31	transcriptome	transcriptome	NN
cord-294366-swwz4kzd	105	32	,	,	,
cord-294366-swwz4kzd	105	33	the	the	DT
cord-294366-swwz4kzd	105	34	complete	complete	JJ
cord-294366-swwz4kzd	105	35	set	set	NN
cord-294366-swwz4kzd	105	36	of	of	IN
cord-294366-swwz4kzd	105	37	transcripts	transcript	NNS
cord-294366-swwz4kzd	105	38	of	of	IN
cord-294366-swwz4kzd	105	39	an	an	DT
cord-294366-swwz4kzd	105	40	organism	organism	NN
cord-294366-swwz4kzd	105	41	.	.	.
cord-294366-swwz4kzd	106	1	Indeed	indeed	RB
cord-294366-swwz4kzd	106	2	,	,	,
cord-294366-swwz4kzd	106	3	in	in	IN
cord-294366-swwz4kzd	106	4	conjunction	conjunction	NN
cord-294366-swwz4kzd	106	5	with	with	IN
cord-294366-swwz4kzd	106	6	proteomics	proteomic	NNS
cord-294366-swwz4kzd	106	7	and	and	CC
cord-294366-swwz4kzd	106	8	comparative	comparative	JJ
cord-294366-swwz4kzd	106	9	genome	genome	NN
cord-294366-swwz4kzd	106	10	analysis	analysis	NN
cord-294366-swwz4kzd	106	11	,	,	,
cord-294366-swwz4kzd	106	12	interpretation	interpretation	NN
cord-294366-swwz4kzd	106	13	of	of	IN
cord-294366-swwz4kzd	106	14	whole	whole	JJ
cord-294366-swwz4kzd	106	15	-	-	HYPH
cord-294366-swwz4kzd	106	16	genome	genome	NN
cord-294366-swwz4kzd	106	17	sequences	sequence	NNS
cord-294366-swwz4kzd	106	18	through	through	IN
cord-294366-swwz4kzd	106	19	bioinformatics	bioinformatic	NNS
cord-294366-swwz4kzd	106	20	(	(	-LRB-
cord-294366-swwz4kzd	106	21	or	or	CC
cord-294366-swwz4kzd	106	22	genomic	genomic	JJ
cord-294366-swwz4kzd	106	23	mining	mining	NN
cord-294366-swwz4kzd	106	24	)	)	-RRB-
cord-294366-swwz4kzd	106	25	can	can	MD
cord-294366-swwz4kzd	106	26	be	be	VB
cord-294366-swwz4kzd	106	27	used	use	VBN
cord-294366-swwz4kzd	106	28	to	to	TO
cord-294366-swwz4kzd	106	29	assign	assign	VB
cord-294366-swwz4kzd	106	30	putative	putative	JJ
cord-294366-swwz4kzd	106	31	gene	gene	NN
cord-294366-swwz4kzd	106	32	functions	function	NNS
cord-294366-swwz4kzd	106	33	to	to	IN
cord-294366-swwz4kzd	106	34	each	each	DT
cord-294366-swwz4kzd	106	35	open	open	JJ
cord-294366-swwz4kzd	106	36	reading	reading	NN
cord-294366-swwz4kzd	106	37	frame	frame	NN
cord-294366-swwz4kzd	106	38	on	on	IN
cord-294366-swwz4kzd	106	39	the	the	DT
cord-294366-swwz4kzd	106	40	basis	basis	NN
cord-294366-swwz4kzd	106	41	of	of	IN
cord-294366-swwz4kzd	106	42	homology	homology	NN
cord-294366-swwz4kzd	106	43	to	to	IN
cord-294366-swwz4kzd	106	44	known	know	VBN
cord-294366-swwz4kzd	106	45	proteins	protein	NNS
cord-294366-swwz4kzd	106	46	[	[	-LRB-
cord-294366-swwz4kzd	106	47	42	42	CD
cord-294366-swwz4kzd	106	48	]	]	-RRB-
cord-294366-swwz4kzd	106	49	.	.	.
cord-294366-swwz4kzd	107	1	Systematic	systematic	JJ
cord-294366-swwz4kzd	107	2	identification	identification	NN
cord-294366-swwz4kzd	107	3	of	of	IN
cord-294366-swwz4kzd	107	4	potential	potential	JJ
cord-294366-swwz4kzd	107	5	antigens	antigen	NNS
cord-294366-swwz4kzd	107	6	of	of	IN
cord-294366-swwz4kzd	107	7	a	a	DT
cord-294366-swwz4kzd	107	8	pathogen	pathogen	NN
cord-294366-swwz4kzd	107	9	using	use	VBG
cord-294366-swwz4kzd	107	10	this	this	DT
cord-294366-swwz4kzd	107	11	information	information	NN
cord-294366-swwz4kzd	107	12	,	,	,
cord-294366-swwz4kzd	107	13	without	without	IN
cord-294366-swwz4kzd	107	14	the	the	DT
cord-294366-swwz4kzd	107	15	need	need	NN
cord-294366-swwz4kzd	107	16	for	for	IN
cord-294366-swwz4kzd	107	17	cultivation	cultivation	NN
cord-294366-swwz4kzd	107	18	of	of	IN
cord-294366-swwz4kzd	107	19	the	the	DT
cord-294366-swwz4kzd	107	20	pathogen	pathogen	NN
cord-294366-swwz4kzd	107	21	,	,	,
cord-294366-swwz4kzd	107	22	is	be	VBZ
cord-294366-swwz4kzd	107	23	termed	term	VBN
cord-294366-swwz4kzd	107	24	'	'	``
cord-294366-swwz4kzd	107	25	reverse	reverse	JJ
cord-294366-swwz4kzd	107	26	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	107	27	'	'	''
cord-294366-swwz4kzd	107	28	[	[	-LRB-
cord-294366-swwz4kzd	107	29	43	43	CD
cord-294366-swwz4kzd	107	30	]	]	-RRB-
cord-294366-swwz4kzd	107	31	and	and	CC
cord-294366-swwz4kzd	107	32	represents	represent	VBZ
cord-294366-swwz4kzd	107	33	a	a	DT
cord-294366-swwz4kzd	107	34	significant	significant	JJ
cord-294366-swwz4kzd	107	35	departure	departure	NN
cord-294366-swwz4kzd	107	36	towards	towards	IN
cord-294366-swwz4kzd	107	37	the	the	DT
cord-294366-swwz4kzd	107	38	idyll	idyll	NN
cord-294366-swwz4kzd	107	39	of	of	IN
cord-294366-swwz4kzd	107	40	rational	rational	JJ
cord-294366-swwz4kzd	107	41	vaccine	vaccine	NN
cord-294366-swwz4kzd	107	42	design	design	NN
cord-294366-swwz4kzd	107	43	described	describe	VBN
cord-294366-swwz4kzd	107	44	above	above	RB
cord-294366-swwz4kzd	107	45	,	,	,
cord-294366-swwz4kzd	107	46	at	at	IN
cord-294366-swwz4kzd	107	47	least	least	JJS
cord-294366-swwz4kzd	107	48	in	in	IN
cord-294366-swwz4kzd	107	49	terms	term	NNS
cord-294366-swwz4kzd	107	50	of	of	IN
cord-294366-swwz4kzd	107	51	dissection	dissection	NN
cord-294366-swwz4kzd	107	52	of	of	IN
cord-294366-swwz4kzd	107	53	potential	potential	JJ
cord-294366-swwz4kzd	107	54	pathogen	pathogen	NN
cord-294366-swwz4kzd	107	55	-	-	HYPH
cord-294366-swwz4kzd	107	56	related	relate	VBN
cord-294366-swwz4kzd	107	57	antigens	antigen	NNS
cord-294366-swwz4kzd	107	58	.	.	.
cord-294366-swwz4kzd	108	1	Knowledge	knowledge	NN
cord-294366-swwz4kzd	108	2	of	of	IN
cord-294366-swwz4kzd	108	3	pathogen	pathogen	NN
cord-294366-swwz4kzd	108	4	interactions	interaction	NNS
cord-294366-swwz4kzd	108	5	during	during	IN
cord-294366-swwz4kzd	108	6	infection	infection	NN
cord-294366-swwz4kzd	108	7	can	can	MD
cord-294366-swwz4kzd	108	8	provide	provide	VB
cord-294366-swwz4kzd	108	9	an	an	DT
cord-294366-swwz4kzd	108	10	invaluable	invaluable	JJ
cord-294366-swwz4kzd	108	11	insight	insight	NN
cord-294366-swwz4kzd	108	12	into	into	IN
cord-294366-swwz4kzd	108	13	potentially	potentially	RB
cord-294366-swwz4kzd	108	14	successful	successful	JJ
cord-294366-swwz4kzd	108	15	targets	target	NNS
cord-294366-swwz4kzd	108	16	for	for	IN
cord-294366-swwz4kzd	108	17	vaccines	vaccine	NNS
cord-294366-swwz4kzd	108	18	.	.	.
cord-294366-swwz4kzd	109	1	For	for	IN
cord-294366-swwz4kzd	109	2	example	example	NN
cord-294366-swwz4kzd	109	3	,	,	,
cord-294366-swwz4kzd	109	4	knowledge	knowledge	NN
cord-294366-swwz4kzd	109	5	of	of	IN
cord-294366-swwz4kzd	109	6	gene	gene	NN
cord-294366-swwz4kzd	109	7	expression	expression	NN
cord-294366-swwz4kzd	109	8	in	in	IN
cord-294366-swwz4kzd	109	9	Mycobacterium	Mycobacterium	NNP
cord-294366-swwz4kzd	109	10	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	109	11	enables	enable	VBZ
cord-294366-swwz4kzd	109	12	us	-PRON-	PRP
cord-294366-swwz4kzd	109	13	to	to	TO
cord-294366-swwz4kzd	109	14	see	see	VB
cord-294366-swwz4kzd	109	15	why	why	WRB
cord-294366-swwz4kzd	109	16	vaccines	vaccine	NNS
cord-294366-swwz4kzd	109	17	based	base	VBN
cord-294366-swwz4kzd	109	18	on	on	IN
cord-294366-swwz4kzd	109	19	early	early	JJ
cord-294366-swwz4kzd	109	20	secreted	secrete	VBN
cord-294366-swwz4kzd	109	21	proteins	protein	NNS
cord-294366-swwz4kzd	109	22	,	,	,
cord-294366-swwz4kzd	109	23	such	such	JJ
cord-294366-swwz4kzd	109	24	as	as	IN
cord-294366-swwz4kzd	109	25	Ag85	Ag85	NNP
cord-294366-swwz4kzd	109	26	and	and	CC
cord-294366-swwz4kzd	109	27	ESAT-6	ESAT-6	NNP
cord-294366-swwz4kzd	109	28	,	,	,
cord-294366-swwz4kzd	109	29	can	can	MD
cord-294366-swwz4kzd	109	30	generate	generate	VB
cord-294366-swwz4kzd	109	31	effective	effective	JJ
cord-294366-swwz4kzd	109	32	pre	pre	JJ
cord-294366-swwz4kzd	109	33	-	-	JJ
cord-294366-swwz4kzd	109	34	exposure	exposure	JJ
cord-294366-swwz4kzd	109	35	vaccines	vaccine	NNS
cord-294366-swwz4kzd	109	36	and	and	CC
cord-294366-swwz4kzd	109	37	helps	help	VBZ
cord-294366-swwz4kzd	109	38	us	-PRON-	PRP
cord-294366-swwz4kzd	109	39	to	to	TO
cord-294366-swwz4kzd	109	40	predict	predict	VB
cord-294366-swwz4kzd	109	41	that	that	IN
cord-294366-swwz4kzd	109	42	an	an	DT
cord-294366-swwz4kzd	109	43	effective	effective	JJ
cord-294366-swwz4kzd	109	44	post	post	JJ
cord-294366-swwz4kzd	109	45	-	-	JJ
cord-294366-swwz4kzd	109	46	exposure	exposure	JJ
cord-294366-swwz4kzd	109	47	vaccine	vaccine	NN
cord-294366-swwz4kzd	109	48	will	will	MD
cord-294366-swwz4kzd	109	49	utilize	utilize	VB
cord-294366-swwz4kzd	109	50	dormancy	dormancy	NN
cord-294366-swwz4kzd	109	51	induced	induce	VBN
cord-294366-swwz4kzd	109	52	proteins	protein	NNS
cord-294366-swwz4kzd	109	53	,	,	,
cord-294366-swwz4kzd	109	54	such	such	JJ
cord-294366-swwz4kzd	109	55	as	as	IN
cord-294366-swwz4kzd	109	56	α	α	NN
cord-294366-swwz4kzd	109	57	-	-	HYPH
cord-294366-swwz4kzd	109	58	crystallin	crystallin	NNP
cord-294366-swwz4kzd	109	59	,	,	,
cord-294366-swwz4kzd	109	60	heat	heat	NN
cord-294366-swwz4kzd	109	61	shock	shock	NN
cord-294366-swwz4kzd	109	62	protein	protein	NN
cord-294366-swwz4kzd	109	63	'	'	POS
cord-294366-swwz4kzd	109	64	HspX	HspX	NNP
cord-294366-swwz4kzd	109	65	'	'	''
cord-294366-swwz4kzd	109	66	[	[	-LRB-
cord-294366-swwz4kzd	109	67	44	44	CD
cord-294366-swwz4kzd	109	68	]	]	-RRB-
cord-294366-swwz4kzd	109	69	.	.	.
cord-294366-swwz4kzd	110	1	In	in	IN
cord-294366-swwz4kzd	110	2	the	the	DT
cord-294366-swwz4kzd	110	3	case	case	NN
cord-294366-swwz4kzd	110	4	of	of	IN
cord-294366-swwz4kzd	110	5	HIV	HIV	NNP
cord-294366-swwz4kzd	110	6	,	,	,
cord-294366-swwz4kzd	110	7	the	the	DT
cord-294366-swwz4kzd	110	8	implication	implication	NN
cord-294366-swwz4kzd	110	9	of	of	IN
cord-294366-swwz4kzd	110	10	lipid	lipid	NN
cord-294366-swwz4kzd	110	11	rafts	raft	NNS
cord-294366-swwz4kzd	110	12	in	in	IN
cord-294366-swwz4kzd	110	13	viral	viral	JJ
cord-294366-swwz4kzd	110	14	entry	entry	NN
cord-294366-swwz4kzd	110	15	and	and	CC
cord-294366-swwz4kzd	110	16	budding	budding	NN
cord-294366-swwz4kzd	110	17	processes	process	NNS
cord-294366-swwz4kzd	110	18	might	may	MD
cord-294366-swwz4kzd	110	19	have	have	VB
cord-294366-swwz4kzd	110	20	provided	provide	VBN
cord-294366-swwz4kzd	110	21	a	a	DT
cord-294366-swwz4kzd	110	22	rationale	rationale	NN
cord-294366-swwz4kzd	110	23	for	for	IN
cord-294366-swwz4kzd	110	24	the	the	DT
cord-294366-swwz4kzd	110	25	evaluation	evaluation	NN
cord-294366-swwz4kzd	110	26	of	of	IN
cord-294366-swwz4kzd	110	27	peptides	peptide	NNS
cord-294366-swwz4kzd	110	28	,	,	,
cord-294366-swwz4kzd	110	29	based	base	VBN
cord-294366-swwz4kzd	110	30	on	on	IN
cord-294366-swwz4kzd	110	31	highly	highly	RB
cord-294366-swwz4kzd	110	32	conserved	conserve	VBN
cord-294366-swwz4kzd	110	33	caveolin-1	caveolin-1	NNP
cord-294366-swwz4kzd	110	34	binding	bind	VBG
cord-294366-swwz4kzd	110	35	domains	domain	NNS
cord-294366-swwz4kzd	110	36	of	of	IN
cord-294366-swwz4kzd	110	37	HIV-1	HIV-1	NNP
cord-294366-swwz4kzd	110	38	glycoprotein	glycoprotein	NN
cord-294366-swwz4kzd	110	39	gp41	gp41	NN
cord-294366-swwz4kzd	110	40	in	in	IN
cord-294366-swwz4kzd	110	41	candidate	candidate	NN
cord-294366-swwz4kzd	110	42	vaccine	vaccine	NN
cord-294366-swwz4kzd	110	43	formulations	formulation	NNS
cord-294366-swwz4kzd	110	44	[	[	-LRB-
cord-294366-swwz4kzd	110	45	45	45	CD
cord-294366-swwz4kzd	110	46	]	]	-RRB-
cord-294366-swwz4kzd	110	47	.	.	.
cord-294366-swwz4kzd	111	1	Encouragingly	encouragingly	RB
cord-294366-swwz4kzd	111	2	,	,	,
cord-294366-swwz4kzd	111	3	this	this	DT
cord-294366-swwz4kzd	111	4	has	have	VBZ
cord-294366-swwz4kzd	111	5	resulted	result	VBN
cord-294366-swwz4kzd	111	6	in	in	IN
cord-294366-swwz4kzd	111	7	peptides	peptide	NNS
cord-294366-swwz4kzd	111	8	capable	capable	JJ
cord-294366-swwz4kzd	111	9	of	of	IN
cord-294366-swwz4kzd	111	10	the	the	DT
cord-294366-swwz4kzd	111	11	elicitation	elicitation	NN
cord-294366-swwz4kzd	111	12	of	of	IN
cord-294366-swwz4kzd	111	13	neutralizing	neutralize	VBG
cord-294366-swwz4kzd	111	14	antibody	antibody	NN
cord-294366-swwz4kzd	111	15	responses	response	NNS
cord-294366-swwz4kzd	111	16	able	able	JJ
cord-294366-swwz4kzd	111	17	to	to	TO
cord-294366-swwz4kzd	111	18	inhibit	inhibit	VB
cord-294366-swwz4kzd	111	19	different	different	JJ
cord-294366-swwz4kzd	111	20	clades	clade	NNS
cord-294366-swwz4kzd	111	21	of	of	IN
cord-294366-swwz4kzd	111	22	HIV-1	HIV-1	NNP
cord-294366-swwz4kzd	111	23	.	.	.
cord-294366-swwz4kzd	112	1	It	-PRON-	PRP
cord-294366-swwz4kzd	112	2	is	be	VBZ
cord-294366-swwz4kzd	112	3	thought	think	VBN
cord-294366-swwz4kzd	112	4	that	that	IN
cord-294366-swwz4kzd	112	5	the	the	DT
cord-294366-swwz4kzd	112	6	poor	poor	JJ
cord-294366-swwz4kzd	112	7	ability	ability	NN
cord-294366-swwz4kzd	112	8	of	of	IN
cord-294366-swwz4kzd	112	9	some	some	DT
cord-294366-swwz4kzd	112	10	specific	specific	JJ
cord-294366-swwz4kzd	112	11	antibodies	antibody	NNS
cord-294366-swwz4kzd	112	12	to	to	TO
cord-294366-swwz4kzd	112	13	neutralize	neutralize	VB
cord-294366-swwz4kzd	112	14	primary	primary	JJ
cord-294366-swwz4kzd	112	15	isolates	isolate	NNS
cord-294366-swwz4kzd	112	16	is	be	VBZ
cord-294366-swwz4kzd	112	17	due	due	JJ
cord-294366-swwz4kzd	112	18	,	,	,
cord-294366-swwz4kzd	112	19	at	at	IN
cord-294366-swwz4kzd	112	20	least	least	JJS
cord-294366-swwz4kzd	112	21	in	in	IN
cord-294366-swwz4kzd	112	22	part	part	NN
cord-294366-swwz4kzd	112	23	,	,	,
cord-294366-swwz4kzd	112	24	to	to	TO
cord-294366-swwz4kzd	112	25	steric	steric	JJ
cord-294366-swwz4kzd	112	26	factors	factor	NNS
cord-294366-swwz4kzd	112	27	that	that	WDT
cord-294366-swwz4kzd	112	28	limit	limit	VBP
cord-294366-swwz4kzd	112	29	antibody	antibody	NN
cord-294366-swwz4kzd	112	30	access	access	NN
cord-294366-swwz4kzd	112	31	to	to	IN
cord-294366-swwz4kzd	112	32	the	the	DT
cord-294366-swwz4kzd	112	33	gp120	gp120	NNP
cord-294366-swwz4kzd	112	34	epitopes	epitope	NNS
cord-294366-swwz4kzd	112	35	[	[	-LRB-
cord-294366-swwz4kzd	112	36	46	46	CD
cord-294366-swwz4kzd	112	37	]	]	-RRB-
cord-294366-swwz4kzd	112	38	.	.	.
cord-294366-swwz4kzd	113	1	Important	important	JJ
cord-294366-swwz4kzd	113	2	factors	factor	NNS
cord-294366-swwz4kzd	113	3	in	in	IN
cord-294366-swwz4kzd	113	4	the	the	DT
cord-294366-swwz4kzd	113	5	rational	rational	JJ
cord-294366-swwz4kzd	113	6	design	design	NN
cord-294366-swwz4kzd	113	7	of	of	IN
cord-294366-swwz4kzd	113	8	vaccines	vaccine	NNS
cord-294366-swwz4kzd	113	9	and	and	CC
cord-294366-swwz4kzd	113	10	the	the	DT
cord-294366-swwz4kzd	113	11	cyclical	cyclical	JJ
cord-294366-swwz4kzd	113	12	generation	generation	NN
cord-294366-swwz4kzd	113	13	of	of	IN
cord-294366-swwz4kzd	113	14	knowledge	knowledge	NN
cord-294366-swwz4kzd	113	15	.	.	.
cord-294366-swwz4kzd	114	1	The	the	DT
cord-294366-swwz4kzd	114	2	level	level	NN
cord-294366-swwz4kzd	114	3	of	of	IN
cord-294366-swwz4kzd	114	4	involvement	involvement	NN
cord-294366-swwz4kzd	114	5	of	of	IN
cord-294366-swwz4kzd	114	6	any	any	DT
cord-294366-swwz4kzd	114	7	of	of	IN
cord-294366-swwz4kzd	114	8	these	these	DT
cord-294366-swwz4kzd	114	9	factors	factor	NNS
cord-294366-swwz4kzd	114	10	depends	depend	VBZ
cord-294366-swwz4kzd	114	11	on	on	IN
cord-294366-swwz4kzd	114	12	the	the	DT
cord-294366-swwz4kzd	114	13	aetiological	aetiological	JJ
cord-294366-swwz4kzd	114	14	agent	agent	NN
cord-294366-swwz4kzd	114	15	of	of	IN
cord-294366-swwz4kzd	114	16	disease	disease	NNP
cord-294366-swwz4kzd	114	17	.	.	.
cord-294366-swwz4kzd	115	1	For	for	IN
cord-294366-swwz4kzd	115	2	example	example	NN
cord-294366-swwz4kzd	115	3	,	,	,
cord-294366-swwz4kzd	115	4	the	the	DT
cord-294366-swwz4kzd	115	5	level	level	NN
cord-294366-swwz4kzd	115	6	of	of	IN
cord-294366-swwz4kzd	115	7	protection	protection	NN
cord-294366-swwz4kzd	115	8	required	require	VBN
cord-294366-swwz4kzd	115	9	in	in	IN
cord-294366-swwz4kzd	115	10	a	a	DT
cord-294366-swwz4kzd	115	11	population	population	NN
cord-294366-swwz4kzd	115	12	(	(	-LRB-
cord-294366-swwz4kzd	115	13	herd	herd	NN
cord-294366-swwz4kzd	115	14	immunity	immunity	NN
cord-294366-swwz4kzd	115	15	)	)	-RRB-
cord-294366-swwz4kzd	115	16	will	will	MD
cord-294366-swwz4kzd	115	17	be	be	VB
cord-294366-swwz4kzd	115	18	different	different	JJ
cord-294366-swwz4kzd	115	19	and	and	CC
cord-294366-swwz4kzd	115	20	this	this	DT
cord-294366-swwz4kzd	115	21	could	could	MD
cord-294366-swwz4kzd	115	22	allow	allow	VB
cord-294366-swwz4kzd	115	23	theoretical	theoretical	JJ
cord-294366-swwz4kzd	115	24	flexibility	flexibility	NN
cord-294366-swwz4kzd	115	25	in	in	IN
cord-294366-swwz4kzd	115	26	vaccine	vaccine	NN
cord-294366-swwz4kzd	115	27	efficacy	efficacy	NN
cord-294366-swwz4kzd	115	28	.	.	.
cord-294366-swwz4kzd	116	1	The	the	DT
cord-294366-swwz4kzd	116	2	application	application	NN
cord-294366-swwz4kzd	116	3	of	of	IN
cord-294366-swwz4kzd	116	4	molecular	molecular	JJ
cord-294366-swwz4kzd	116	5	biology	biology	NN
cord-294366-swwz4kzd	116	6	techniques	technique	NNS
cord-294366-swwz4kzd	116	7	can	can	MD
cord-294366-swwz4kzd	116	8	be	be	VB
cord-294366-swwz4kzd	116	9	crucial	crucial	JJ
cord-294366-swwz4kzd	116	10	in	in	IN
cord-294366-swwz4kzd	116	11	the	the	DT
cord-294366-swwz4kzd	116	12	identification	identification	NN
cord-294366-swwz4kzd	116	13	of	of	IN
cord-294366-swwz4kzd	116	14	new	new	JJ
cord-294366-swwz4kzd	116	15	candidate	candidate	NN
cord-294366-swwz4kzd	116	16	antigens	antigen	NNS
cord-294366-swwz4kzd	116	17	and	and	CC
cord-294366-swwz4kzd	116	18	subsequent	subsequent	JJ
cord-294366-swwz4kzd	116	19	determination	determination	NN
cord-294366-swwz4kzd	116	20	of	of	IN
cord-294366-swwz4kzd	116	21	vaccine	vaccine	NN
cord-294366-swwz4kzd	116	22	efficacy	efficacy	NN
cord-294366-swwz4kzd	116	23	using	use	VBG
cord-294366-swwz4kzd	116	24	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	116	25	can	can	MD
cord-294366-swwz4kzd	116	26	feed	feed	VB
cord-294366-swwz4kzd	116	27	knowledge	knowledge	NN
cord-294366-swwz4kzd	116	28	back	back	RB
cord-294366-swwz4kzd	116	29	to	to	IN
cord-294366-swwz4kzd	116	30	correlates	correlate	NNS
cord-294366-swwz4kzd	116	31	of	of	IN
cord-294366-swwz4kzd	116	32	protection	protection	NN
cord-294366-swwz4kzd	116	33	in	in	IN
cord-294366-swwz4kzd	116	34	terms	term	NNS
cord-294366-swwz4kzd	116	35	of	of	IN
cord-294366-swwz4kzd	116	36	immunological	immunological	JJ
cord-294366-swwz4kzd	116	37	markers	marker	NNS
cord-294366-swwz4kzd	116	38	.	.	.
cord-294366-swwz4kzd	117	1	This	this	DT
cord-294366-swwz4kzd	117	2	knowledge	knowledge	NN
cord-294366-swwz4kzd	117	3	can	can	MD
cord-294366-swwz4kzd	117	4	then	then	RB
cord-294366-swwz4kzd	117	5	be	be	VB
cord-294366-swwz4kzd	117	6	used	use	VBN
cord-294366-swwz4kzd	117	7	in	in	IN
cord-294366-swwz4kzd	117	8	choice	choice	NN
cord-294366-swwz4kzd	117	9	of	of	IN
cord-294366-swwz4kzd	117	10	appropriate	appropriate	JJ
cord-294366-swwz4kzd	117	11	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	117	12	and	and	CC
cord-294366-swwz4kzd	117	13	formulation	formulation	NN
cord-294366-swwz4kzd	117	14	.	.	.
cord-294366-swwz4kzd	118	1	The	the	DT
cord-294366-swwz4kzd	118	2	key	key	JJ
cord-294366-swwz4kzd	118	3	implication	implication	NN
cord-294366-swwz4kzd	118	4	projected	project	VBN
cord-294366-swwz4kzd	118	5	by	by	IN
cord-294366-swwz4kzd	118	6	this	this	DT
cord-294366-swwz4kzd	118	7	schematic	schematic	NN
cord-294366-swwz4kzd	118	8	is	be	VBZ
cord-294366-swwz4kzd	118	9	that	that	DT
cord-294366-swwz4kzd	118	10	for	for	IN
cord-294366-swwz4kzd	118	11	the	the	DT
cord-294366-swwz4kzd	118	12	greatest	great	JJS
cord-294366-swwz4kzd	118	13	challenges	challenge	NNS
cord-294366-swwz4kzd	118	14	in	in	IN
cord-294366-swwz4kzd	118	15	vaccine	vaccine	NN
cord-294366-swwz4kzd	118	16	development	development	NN
cord-294366-swwz4kzd	118	17	the	the	DT
cord-294366-swwz4kzd	118	18	cyclical	cyclical	JJ
cord-294366-swwz4kzd	118	19	generation	generation	NN
cord-294366-swwz4kzd	118	20	of	of	IN
cord-294366-swwz4kzd	118	21	knowledge	knowledge	NN
cord-294366-swwz4kzd	118	22	provides	provide	VBZ
cord-294366-swwz4kzd	118	23	a	a	DT
cord-294366-swwz4kzd	118	24	strong	strong	JJ
cord-294366-swwz4kzd	118	25	role	role	NN
cord-294366-swwz4kzd	118	26	for	for	IN
cord-294366-swwz4kzd	118	27	rational	rational	JJ
cord-294366-swwz4kzd	118	28	design	design	NN
cord-294366-swwz4kzd	118	29	.	.	.
cord-294366-swwz4kzd	119	1	*	*	NFP
cord-294366-swwz4kzd	119	2	Can	Can	MD
cord-294366-swwz4kzd	119	3	be	be	VB
cord-294366-swwz4kzd	119	4	protective	protective	JJ
cord-294366-swwz4kzd	119	5	or	or	CC
cord-294366-swwz4kzd	119	6	therapeutic	therapeutic	JJ
cord-294366-swwz4kzd	119	7	.	.	.
cord-294366-swwz4kzd	120	1	*	*	NFP
cord-294366-swwz4kzd	120	2	*	*	NFP
cord-294366-swwz4kzd	120	3	Including	include	VBG
cord-294366-swwz4kzd	120	4	reverse	reverse	JJ
cord-294366-swwz4kzd	120	5	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	120	6	and	and	CC
cord-294366-swwz4kzd	120	7	associated	associated	JJ
cord-294366-swwz4kzd	120	8	technologies	technology	NNS
cord-294366-swwz4kzd	120	9	.	.	.
cord-294366-swwz4kzd	121	1	Correlates	correlate	NNS
cord-294366-swwz4kzd	121	2	of	of	IN
cord-294366-swwz4kzd	121	3	protection	protection	NN
cord-294366-swwz4kzd	121	4	*	*	NFP
cord-294366-swwz4kzd	121	5	Immunological	immunological	JJ
cord-294366-swwz4kzd	121	6	markers	marker	NNS
cord-294366-swwz4kzd	121	7	Defining	define	VBG
cord-294366-swwz4kzd	121	8	protective	protective	JJ
cord-294366-swwz4kzd	121	9	*	*	NFP
cord-294366-swwz4kzd	121	10	antigens	antigen	NNS
cord-294366-swwz4kzd	121	11	Antibodies	Antibodies	NNPS
cord-294366-swwz4kzd	121	12	against	against	IN
cord-294366-swwz4kzd	121	13	the	the	DT
cord-294366-swwz4kzd	121	14	caveolin-1	caveolin-1	NNP
cord-294366-swwz4kzd	121	15	binding	binding	NN
cord-294366-swwz4kzd	121	16	domains	domain	NNS
cord-294366-swwz4kzd	121	17	are	be	VBP
cord-294366-swwz4kzd	121	18	rare	rare	JJ
cord-294366-swwz4kzd	121	19	in	in	IN
cord-294366-swwz4kzd	121	20	many	many	JJ
cord-294366-swwz4kzd	121	21	HIV	HIV	NNP
cord-294366-swwz4kzd	121	22	infected	infect	VBN
cord-294366-swwz4kzd	121	23	individuals	individual	NNS
cord-294366-swwz4kzd	121	24	,	,	,
cord-294366-swwz4kzd	121	25	possibly	possibly	RB
cord-294366-swwz4kzd	121	26	because	because	IN
cord-294366-swwz4kzd	121	27	of	of	IN
cord-294366-swwz4kzd	121	28	the	the	DT
cord-294366-swwz4kzd	121	29	presence	presence	NN
cord-294366-swwz4kzd	121	30	of	of	IN
cord-294366-swwz4kzd	121	31	hypervariable	hypervariable	NNP
cord-294366-swwz4kzd	121	32	immunodominant	immunodominant	JJ
cord-294366-swwz4kzd	121	33	epitopes	epitope	NNS
cord-294366-swwz4kzd	121	34	or	or	CC
cord-294366-swwz4kzd	121	35	the	the	DT
cord-294366-swwz4kzd	121	36	location	location	NN
cord-294366-swwz4kzd	121	37	and	and	CC
cord-294366-swwz4kzd	121	38	lack	lack	NN
cord-294366-swwz4kzd	121	39	of	of	IN
cord-294366-swwz4kzd	121	40	exposure	exposure	NN
cord-294366-swwz4kzd	121	41	of	of	IN
cord-294366-swwz4kzd	121	42	conserved	conserved	JJ
cord-294366-swwz4kzd	121	43	regions	region	NNS
cord-294366-swwz4kzd	121	44	.	.	.
cord-294366-swwz4kzd	122	1	The	the	DT
cord-294366-swwz4kzd	122	2	proposed	propose	VBN
cord-294366-swwz4kzd	122	3	opportunities	opportunity	NNS
cord-294366-swwz4kzd	122	4	for	for	IN
cord-294366-swwz4kzd	122	5	vaccines	vaccine	NNS
cord-294366-swwz4kzd	122	6	against	against	IN
cord-294366-swwz4kzd	122	7	HIV	HIV	NNP
cord-294366-swwz4kzd	122	8	and	and	CC
cord-294366-swwz4kzd	122	9	TB	TB	NNP
cord-294366-swwz4kzd	122	10	are	be	VBP
cord-294366-swwz4kzd	122	11	summarized	summarize	VBN
cord-294366-swwz4kzd	122	12	in	in	IN
cord-294366-swwz4kzd	122	13	Figure	Figure	NNP
cord-294366-swwz4kzd	122	14	3	3	CD
cord-294366-swwz4kzd	122	15	;	;	:
cord-294366-swwz4kzd	122	16	the	the	DT
cord-294366-swwz4kzd	122	17	rationale	rationale	NN
cord-294366-swwz4kzd	122	18	for	for	IN
cord-294366-swwz4kzd	122	19	elicitation	elicitation	NN
cord-294366-swwz4kzd	122	20	of	of	IN
cord-294366-swwz4kzd	122	21	successfully	successfully	RB
cord-294366-swwz4kzd	122	22	neutralizing	neutralize	VBG
cord-294366-swwz4kzd	122	23	antibodies	antibody	NNS
cord-294366-swwz4kzd	122	24	against	against	IN
cord-294366-swwz4kzd	122	25	HIV	HIV	NNP
cord-294366-swwz4kzd	122	26	is	be	VBZ
cord-294366-swwz4kzd	122	27	centred	centre	VBN
cord-294366-swwz4kzd	122	28	upon	upon	IN
cord-294366-swwz4kzd	122	29	increasing	increase	VBG
cord-294366-swwz4kzd	122	30	the	the	DT
cord-294366-swwz4kzd	122	31	immunogenicity	immunogenicity	NN
cord-294366-swwz4kzd	122	32	of	of	IN
cord-294366-swwz4kzd	122	33	poorly	poorly	RB
cord-294366-swwz4kzd	122	34	immunogenic	immunogenic	JJ
cord-294366-swwz4kzd	122	35	peptides	peptide	NNS
cord-294366-swwz4kzd	122	36	,	,	,
cord-294366-swwz4kzd	122	37	modification	modification	NN
cord-294366-swwz4kzd	122	38	and/or	and/or	CC
cord-294366-swwz4kzd	122	39	removal	removal	NN
cord-294366-swwz4kzd	122	40	of	of	IN
cord-294366-swwz4kzd	122	41	hypervariable	hypervariable	JJ
cord-294366-swwz4kzd	122	42	regions	region	NNS
cord-294366-swwz4kzd	122	43	and	and	CC
cord-294366-swwz4kzd	122	44	mimicking	mimic	VBG
cord-294366-swwz4kzd	122	45	viral	viral	JJ
cord-294366-swwz4kzd	122	46	conformational	conformational	JJ
cord-294366-swwz4kzd	122	47	changes	change	NNS
cord-294366-swwz4kzd	122	48	.	.	.
cord-294366-swwz4kzd	123	1	One	one	CD
cord-294366-swwz4kzd	123	2	of	of	IN
cord-294366-swwz4kzd	123	3	the	the	DT
cord-294366-swwz4kzd	123	4	hottest	hot	JJS
cord-294366-swwz4kzd	123	5	areas	area	NNS
cord-294366-swwz4kzd	123	6	of	of	IN
cord-294366-swwz4kzd	123	7	interest	interest	NN
cord-294366-swwz4kzd	123	8	regarding	regard	VBG
cord-294366-swwz4kzd	123	9	new	new	JJ
cord-294366-swwz4kzd	123	10	vaccine	vaccine	NN
cord-294366-swwz4kzd	123	11	development	development	NN
cord-294366-swwz4kzd	123	12	surrounds	surround	VBZ
cord-294366-swwz4kzd	123	13	the	the	DT
cord-294366-swwz4kzd	123	14	Phase	Phase	NNP
cord-294366-swwz4kzd	123	15	III	III	NNP
cord-294366-swwz4kzd	123	16	efficacy	efficacy	NN
cord-294366-swwz4kzd	123	17	trials	trial	NNS
cord-294366-swwz4kzd	123	18	and	and	CC
cord-294366-swwz4kzd	123	19	prospective	prospective	JJ
cord-294366-swwz4kzd	123	20	licensure	licensure	NN
cord-294366-swwz4kzd	123	21	of	of	IN
cord-294366-swwz4kzd	123	22	two	two	CD
cord-294366-swwz4kzd	123	23	vaccines	vaccine	NNS
cord-294366-swwz4kzd	123	24	against	against	IN
cord-294366-swwz4kzd	123	25	human	human	JJ
cord-294366-swwz4kzd	123	26	papillomavirus	papillomavirus	NN
cord-294366-swwz4kzd	123	27	(	(	-LRB-
cord-294366-swwz4kzd	123	28	HPV	HPV	NNP
cord-294366-swwz4kzd	123	29	)	)	-RRB-
cord-294366-swwz4kzd	124	1	[	[	-LRB-
cord-294366-swwz4kzd	124	2	47	47	CD
cord-294366-swwz4kzd	124	3	]	]	-RRB-
cord-294366-swwz4kzd	124	4	.	.	.
cord-294366-swwz4kzd	125	1	The	the	DT
cord-294366-swwz4kzd	125	2	vaccines	vaccine	NNS
cord-294366-swwz4kzd	125	3	,	,	,
cord-294366-swwz4kzd	125	4	one	one	CD
cord-294366-swwz4kzd	125	5	from	from	IN
cord-294366-swwz4kzd	125	6	Merck	Merck	NNP
cord-294366-swwz4kzd	125	7	and	and	CC
cord-294366-swwz4kzd	125	8	one	one	CD
cord-294366-swwz4kzd	125	9	from	from	IN
cord-294366-swwz4kzd	125	10	GSK	GSK	NNP
cord-294366-swwz4kzd	125	11	,	,	,
cord-294366-swwz4kzd	125	12	are	be	VBP
cord-294366-swwz4kzd	125	13	effectively	effectively	RB
cord-294366-swwz4kzd	125	14	vaccines	vaccine	NNS
cord-294366-swwz4kzd	125	15	against	against	IN
cord-294366-swwz4kzd	125	16	cervical	cervical	JJ
cord-294366-swwz4kzd	125	17	cancer	cancer	NN
cord-294366-swwz4kzd	125	18	;	;	:
cord-294366-swwz4kzd	125	19	the	the	DT
cord-294366-swwz4kzd	125	20	(	(	-LRB-
cord-294366-swwz4kzd	125	21	now	now	RB
cord-294366-swwz4kzd	125	22	)	)	-RRB-
cord-294366-swwz4kzd	125	23	unequivocal	unequivocal	JJ
cord-294366-swwz4kzd	125	24	link	link	NN
cord-294366-swwz4kzd	125	25	between	between	IN
cord-294366-swwz4kzd	125	26	this	this	DT
cord-294366-swwz4kzd	125	27	common	common	JJ
cord-294366-swwz4kzd	125	28	virus	virus	NN
cord-294366-swwz4kzd	125	29	,	,	,
cord-294366-swwz4kzd	125	30	which	which	WDT
cord-294366-swwz4kzd	125	31	rarely	rarely	RB
cord-294366-swwz4kzd	125	32	causes	cause	VBZ
cord-294366-swwz4kzd	125	33	serious	serious	JJ
cord-294366-swwz4kzd	125	34	disease	disease	NN
cord-294366-swwz4kzd	125	35	in	in	IN
cord-294366-swwz4kzd	125	36	itself	-PRON-	PRP
cord-294366-swwz4kzd	125	37	,	,	,
cord-294366-swwz4kzd	125	38	and	and	CC
cord-294366-swwz4kzd	125	39	cervical	cervical	JJ
cord-294366-swwz4kzd	125	40	cancer	cancer	NN
cord-294366-swwz4kzd	125	41	found	find	VBD
cord-294366-swwz4kzd	125	42	credence	credence	NN
cord-294366-swwz4kzd	125	43	as	as	IN
cord-294366-swwz4kzd	125	44	long	long	RB
cord-294366-swwz4kzd	125	45	ago	ago	RB
cord-294366-swwz4kzd	125	46	as	as	IN
cord-294366-swwz4kzd	125	47	the	the	DT
cord-294366-swwz4kzd	125	48	1970s	1970s	CD
cord-294366-swwz4kzd	125	49	.	.	.
cord-294366-swwz4kzd	126	1	The	the	DT
cord-294366-swwz4kzd	126	2	production	production	NN
cord-294366-swwz4kzd	126	3	of	of	IN
cord-294366-swwz4kzd	126	4	both	both	DT
cord-294366-swwz4kzd	126	5	vaccines	vaccine	NNS
cord-294366-swwz4kzd	126	6	(	(	-LRB-
cord-294366-swwz4kzd	126	7	the	the	DT
cord-294366-swwz4kzd	126	8	Merck	Merck	NNP
cord-294366-swwz4kzd	126	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	126	10	produced	produce	VBN
cord-294366-swwz4kzd	126	11	in	in	IN
cord-294366-swwz4kzd	126	12	yeast	yeast	NN
cord-294366-swwz4kzd	126	13	administered	administer	VBN
cord-294366-swwz4kzd	126	14	with	with	IN
cord-294366-swwz4kzd	126	15	an	an	DT
cord-294366-swwz4kzd	126	16	aluminium	aluminium	NN
cord-294366-swwz4kzd	126	17	adjuvant	adjuvant	NN
cord-294366-swwz4kzd	126	18	and	and	CC
cord-294366-swwz4kzd	126	19	the	the	DT
cord-294366-swwz4kzd	126	20	GSK	GSK	NNP
cord-294366-swwz4kzd	126	21	vaccine	vaccine	NN
cord-294366-swwz4kzd	126	22	in	in	IN
cord-294366-swwz4kzd	126	23	baculovirus	baculovirus	NNP
cord-294366-swwz4kzd	126	24	with	with	IN
cord-294366-swwz4kzd	126	25	the	the	DT
cord-294366-swwz4kzd	126	26	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	126	27	AS04	AS04	NNP
cord-294366-swwz4kzd	126	28	;	;	:
cord-294366-swwz4kzd	126	29	aluminium	aluminium	NN
cord-294366-swwz4kzd	126	30	and	and	CC
cord-294366-swwz4kzd	126	31	bacterial	bacterial	JJ
cord-294366-swwz4kzd	126	32	lipid	lipid	NN
cord-294366-swwz4kzd	126	33	already	already	RB
cord-294366-swwz4kzd	126	34	approved	approve	VBN
cord-294366-swwz4kzd	126	35	for	for	IN
cord-294366-swwz4kzd	126	36	use	use	NN
cord-294366-swwz4kzd	126	37	in	in	IN
cord-294366-swwz4kzd	126	38	Europe	Europe	NNP
cord-294366-swwz4kzd	126	39	)	)	-RRB-
cord-294366-swwz4kzd	126	40	has	have	VBZ
cord-294366-swwz4kzd	126	41	its	-PRON-	PRP$
cord-294366-swwz4kzd	126	42	basis	basis	NN
cord-294366-swwz4kzd	126	43	in	in	IN
cord-294366-swwz4kzd	126	44	work	work	NN
cord-294366-swwz4kzd	126	45	that	that	WDT
cord-294366-swwz4kzd	126	46	elucidated	elucidate	VBD
cord-294366-swwz4kzd	126	47	the	the	DT
cord-294366-swwz4kzd	126	48	production	production	NN
cord-294366-swwz4kzd	126	49	and	and	CC
cord-294366-swwz4kzd	126	50	self	self	NN
cord-294366-swwz4kzd	126	51	-	-	HYPH
cord-294366-swwz4kzd	126	52	assembly	assembly	NN
cord-294366-swwz4kzd	126	53	of	of	IN
cord-294366-swwz4kzd	126	54	virus	virus	NN
cord-294366-swwz4kzd	126	55	-	-	HYPH
cord-294366-swwz4kzd	126	56	like	like	JJ
cord-294366-swwz4kzd	126	57	particles	particle	NNS
cord-294366-swwz4kzd	126	58	of	of	IN
cord-294366-swwz4kzd	126	59	the	the	DT
cord-294366-swwz4kzd	126	60	HPV	HPV	NNP
cord-294366-swwz4kzd	126	61	outer	outer	JJ
cord-294366-swwz4kzd	126	62	L1	L1	NNP
cord-294366-swwz4kzd	126	63	and	and	CC
cord-294366-swwz4kzd	126	64	L2	L2	NNP
cord-294366-swwz4kzd	126	65	coat	coat	NN
cord-294366-swwz4kzd	126	66	proteins	protein	NNS
cord-294366-swwz4kzd	126	67	[	[	-LRB-
cord-294366-swwz4kzd	126	68	48	48	CD
cord-294366-swwz4kzd	126	69	,	,	,
cord-294366-swwz4kzd	126	70	49	49	CD
cord-294366-swwz4kzd	126	71	]	]	-RRB-
cord-294366-swwz4kzd	126	72	in	in	IN
cord-294366-swwz4kzd	126	73	various	various	JJ
cord-294366-swwz4kzd	126	74	cell	cell	NN
cord-294366-swwz4kzd	126	75	types	type	NNS
cord-294366-swwz4kzd	126	76	.	.	.
cord-294366-swwz4kzd	127	1	Vaccines	vaccine	NNS
cord-294366-swwz4kzd	127	2	against	against	IN
cord-294366-swwz4kzd	127	3	most	most	JJS
cord-294366-swwz4kzd	127	4	Neisseria	Neisseria	NNP
cord-294366-swwz4kzd	127	5	meningitidis	meningitidis	NN
cord-294366-swwz4kzd	127	6	serogroups	serogroup	NNS
cord-294366-swwz4kzd	127	7	have	have	VBP
cord-294366-swwz4kzd	127	8	been	be	VBN
cord-294366-swwz4kzd	127	9	developed	develop	VBN
cord-294366-swwz4kzd	127	10	using	use	VBG
cord-294366-swwz4kzd	127	11	traditional	traditional	JJ
cord-294366-swwz4kzd	127	12	approaches	approach	NNS
cord-294366-swwz4kzd	127	13	.	.	.
cord-294366-swwz4kzd	128	1	However	however	RB
cord-294366-swwz4kzd	128	2	,	,	,
cord-294366-swwz4kzd	128	3	group	group	NN
cord-294366-swwz4kzd	128	4	B	B	NNP
cord-294366-swwz4kzd	128	5	meningococcus	meningococcus	NNP
cord-294366-swwz4kzd	128	6	has	have	VBZ
cord-294366-swwz4kzd	128	7	represented	represent	VBN
cord-294366-swwz4kzd	128	8	a	a	DT
cord-294366-swwz4kzd	128	9	particular	particular	JJ
cord-294366-swwz4kzd	128	10	challenge	challenge	NN
cord-294366-swwz4kzd	128	11	because	because	IN
cord-294366-swwz4kzd	128	12	of	of	IN
cord-294366-swwz4kzd	128	13	the	the	DT
cord-294366-swwz4kzd	128	14	sequence	sequence	NN
cord-294366-swwz4kzd	128	15	variation	variation	NN
cord-294366-swwz4kzd	128	16	of	of	IN
cord-294366-swwz4kzd	128	17	surface	surface	NN
cord-294366-swwz4kzd	128	18	proteins	protein	NNS
cord-294366-swwz4kzd	128	19	and	and	CC
cord-294366-swwz4kzd	128	20	crossreactivity	crossreactivity	NN
cord-294366-swwz4kzd	128	21	of	of	IN
cord-294366-swwz4kzd	128	22	the	the	DT
cord-294366-swwz4kzd	128	23	capsular	capsular	JJ
cord-294366-swwz4kzd	128	24	polysaccharide	polysaccharide	NN
cord-294366-swwz4kzd	128	25	Proposed	propose	VBN
cord-294366-swwz4kzd	128	26	opportunities	opportunity	NNS
cord-294366-swwz4kzd	128	27	for	for	IN
cord-294366-swwz4kzd	128	28	vaccination	vaccination	NN
cord-294366-swwz4kzd	128	29	against	against	IN
cord-294366-swwz4kzd	128	30	TB	TB	NNP
cord-294366-swwz4kzd	128	31	and	and	CC
cord-294366-swwz4kzd	128	32	HIV	HIV	NNP
cord-294366-swwz4kzd	128	33	.	.	.
cord-294366-swwz4kzd	129	1	In	in	IN
cord-294366-swwz4kzd	129	2	both	both	DT
cord-294366-swwz4kzd	129	3	cases	case	NNS
cord-294366-swwz4kzd	129	4	,	,	,
cord-294366-swwz4kzd	129	5	the	the	DT
cord-294366-swwz4kzd	129	6	utilization	utilization	NN
cord-294366-swwz4kzd	129	7	of	of	IN
cord-294366-swwz4kzd	129	8	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	129	9	capable	capable	JJ
cord-294366-swwz4kzd	129	10	of	of	IN
cord-294366-swwz4kzd	129	11	driving	drive	VBG
cord-294366-swwz4kzd	129	12	the	the	DT
cord-294366-swwz4kzd	129	13	required	require	VBN
cord-294366-swwz4kzd	129	14	type	type	NN
cord-294366-swwz4kzd	129	15	of	of	IN
cord-294366-swwz4kzd	129	16	immune	immune	JJ
cord-294366-swwz4kzd	129	17	response	response	NN
cord-294366-swwz4kzd	129	18	can	can	MD
cord-294366-swwz4kzd	129	19	be	be	VB
cord-294366-swwz4kzd	129	20	used	use	VBN
cord-294366-swwz4kzd	129	21	.	.	.
cord-294366-swwz4kzd	130	1	This	this	DT
cord-294366-swwz4kzd	130	2	can	can	MD
cord-294366-swwz4kzd	130	3	be	be	VB
cord-294366-swwz4kzd	130	4	based	base	VBN
cord-294366-swwz4kzd	130	5	on	on	IN
cord-294366-swwz4kzd	130	6	our	-PRON-	PRP$
cord-294366-swwz4kzd	130	7	current	current	JJ
cord-294366-swwz4kzd	130	8	understanding	understanding	NN
cord-294366-swwz4kzd	130	9	of	of	IN
cord-294366-swwz4kzd	130	10	TLR	TLR	NNP
cord-294366-swwz4kzd	130	11	interaction	interaction	NN
cord-294366-swwz4kzd	130	12	,	,	,
cord-294366-swwz4kzd	130	13	and	and	CC
cord-294366-swwz4kzd	130	14	studies	study	NNS
cord-294366-swwz4kzd	130	15	that	that	WDT
cord-294366-swwz4kzd	130	16	manipulate	manipulate	VBP
cord-294366-swwz4kzd	130	17	this	this	DT
cord-294366-swwz4kzd	130	18	understanding	understanding	NN
cord-294366-swwz4kzd	130	19	might	may	MD
cord-294366-swwz4kzd	130	20	also	also	RB
cord-294366-swwz4kzd	130	21	serve	serve	VB
cord-294366-swwz4kzd	130	22	to	to	TO
cord-294366-swwz4kzd	130	23	elucidate	elucidate	VB
cord-294366-swwz4kzd	130	24	complex	complex	JJ
cord-294366-swwz4kzd	130	25	interactions	interaction	NNS
cord-294366-swwz4kzd	130	26	during	during	IN
cord-294366-swwz4kzd	130	27	infection	infection	NN
cord-294366-swwz4kzd	130	28	and	and	CC
cord-294366-swwz4kzd	130	29	disease	disease	NN
cord-294366-swwz4kzd	130	30	.	.	.
cord-294366-swwz4kzd	131	1	(	(	-LRB-
cord-294366-swwz4kzd	131	2	a	a	LS
cord-294366-swwz4kzd	131	3	)	)	-RRB-
cord-294366-swwz4kzd	132	1	According	accord	VBG
cord-294366-swwz4kzd	132	2	to	to	IN
cord-294366-swwz4kzd	132	3	recent	recent	JJ
cord-294366-swwz4kzd	132	4	models	model	NNS
cord-294366-swwz4kzd	132	5	,	,	,
cord-294366-swwz4kzd	132	6	antigen	antigen	NN
cord-294366-swwz4kzd	132	7	specific	specific	JJ
cord-294366-swwz4kzd	132	8	CD4	CD4	NNP
cord-294366-swwz4kzd	132	9	+	+	CC
cord-294366-swwz4kzd	132	10	T	t	NN
cord-294366-swwz4kzd	132	11	cells	cell	NNS
cord-294366-swwz4kzd	132	12	,	,	,
cord-294366-swwz4kzd	132	13	CD8	CD8	NNP
cord-294366-swwz4kzd	132	14	+	+	CC
cord-294366-swwz4kzd	132	15	T	T	NNP
cord-294366-swwz4kzd	132	16	cells	cell	NNS
cord-294366-swwz4kzd	132	17	,	,	,
cord-294366-swwz4kzd	132	18	γδ	γδ	CC
cord-294366-swwz4kzd	132	19	T	t	NN
cord-294366-swwz4kzd	132	20	cells	cell	NNS
cord-294366-swwz4kzd	132	21	and	and	CC
cord-294366-swwz4kzd	132	22	CD1	CD1	NNP
cord-294366-swwz4kzd	132	23	restricted	restrict	VBD
cord-294366-swwz4kzd	132	24	T	t	NN
cord-294366-swwz4kzd	132	25	cells	cell	NNS
cord-294366-swwz4kzd	132	26	,	,	,
cord-294366-swwz4kzd	132	27	all	all	DT
cord-294366-swwz4kzd	132	28	participate	participate	VBP
cord-294366-swwz4kzd	132	29	in	in	IN
cord-294366-swwz4kzd	132	30	protection	protection	NN
cord-294366-swwz4kzd	132	31	against	against	IN
cord-294366-swwz4kzd	132	32	M.	M.	NNP
cord-294366-swwz4kzd	132	33	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	132	34	infection	infection	NN
cord-294366-swwz4kzd	132	35	in	in	IN
cord-294366-swwz4kzd	132	36	response	response	NN
cord-294366-swwz4kzd	132	37	to	to	IN
cord-294366-swwz4kzd	132	38	antigen	antigen	NN
cord-294366-swwz4kzd	132	39	presentation	presentation	NN
cord-294366-swwz4kzd	132	40	by	by	IN
cord-294366-swwz4kzd	132	41	macrophages	macrophage	NNS
cord-294366-swwz4kzd	132	42	(	(	-LRB-
cord-294366-swwz4kzd	132	43	MΦ	MΦ	NNP
cord-294366-swwz4kzd	132	44	)	)	-RRB-
cord-294366-swwz4kzd	132	45	and	and	CC
cord-294366-swwz4kzd	132	46	dendritic	dendritic	JJ
cord-294366-swwz4kzd	132	47	cells	cell	NNS
cord-294366-swwz4kzd	132	48	(	(	-LRB-
cord-294366-swwz4kzd	132	49	DC	DC	NNP
cord-294366-swwz4kzd	132	50	)	)	-RRB-
cord-294366-swwz4kzd	132	51	,	,	,
cord-294366-swwz4kzd	132	52	probably	probably	RB
cord-294366-swwz4kzd	132	53	also	also	RB
cord-294366-swwz4kzd	132	54	involving	involve	VBG
cord-294366-swwz4kzd	132	55	crosspriming	crosspriming	NN
cord-294366-swwz4kzd	132	56	,	,	,
cord-294366-swwz4kzd	132	57	where	where	WRB
cord-294366-swwz4kzd	132	58	mycobacterial	mycobacterial	JJ
cord-294366-swwz4kzd	132	59	antigens	antigen	NNS
cord-294366-swwz4kzd	132	60	are	be	VBP
cord-294366-swwz4kzd	132	61	transferred	transfer	VBN
cord-294366-swwz4kzd	132	62	from	from	IN
cord-294366-swwz4kzd	132	63	infected	infected	JJ
cord-294366-swwz4kzd	132	64	MΦ	MΦ	NNP
cord-294366-swwz4kzd	132	65	to	to	IN
cord-294366-swwz4kzd	132	66	DC	DC	NNP
cord-294366-swwz4kzd	132	67	.	.	.
cord-294366-swwz4kzd	133	1	It	-PRON-	PRP
cord-294366-swwz4kzd	133	2	is	be	VBZ
cord-294366-swwz4kzd	133	3	unlikely	unlikely	JJ
cord-294366-swwz4kzd	133	4	that	that	IN
cord-294366-swwz4kzd	133	5	the	the	DT
cord-294366-swwz4kzd	133	6	induction	induction	NN
cord-294366-swwz4kzd	133	7	of	of	IN
cord-294366-swwz4kzd	133	8	IFN	IFN	NNP
cord-294366-swwz4kzd	133	9	-	-	HYPH
cord-294366-swwz4kzd	133	10	γ	γ	NNP
cord-294366-swwz4kzd	133	11	or	or	CC
cord-294366-swwz4kzd	133	12	the	the	DT
cord-294366-swwz4kzd	133	13	production	production	NN
cord-294366-swwz4kzd	133	14	of	of	IN
cord-294366-swwz4kzd	133	15	inducible	inducible	JJ
cord-294366-swwz4kzd	133	16	nitric	nitric	NN
cord-294366-swwz4kzd	133	17	oxide	oxide	NN
cord-294366-swwz4kzd	133	18	synthase	synthase	NN
cord-294366-swwz4kzd	133	19	alone	alone	RB
cord-294366-swwz4kzd	133	20	is	be	VBZ
cord-294366-swwz4kzd	133	21	enough	enough	JJ
cord-294366-swwz4kzd	133	22	to	to	TO
cord-294366-swwz4kzd	133	23	control	control	VB
cord-294366-swwz4kzd	133	24	TB	TB	NNP
cord-294366-swwz4kzd	133	25	infection	infection	NN
cord-294366-swwz4kzd	133	26	,	,	,
cord-294366-swwz4kzd	133	27	and	and	CC
cord-294366-swwz4kzd	133	28	evidence	evidence	NN
cord-294366-swwz4kzd	133	29	indicates	indicate	VBZ
cord-294366-swwz4kzd	133	30	that	that	IN
cord-294366-swwz4kzd	133	31	there	there	EX
cord-294366-swwz4kzd	133	32	might	may	MD
cord-294366-swwz4kzd	133	33	be	be	VB
cord-294366-swwz4kzd	133	34	another	another	DT
cord-294366-swwz4kzd	133	35	role	role	NN
cord-294366-swwz4kzd	133	36	for	for	IN
cord-294366-swwz4kzd	133	37	CD4	CD4	NNP
cord-294366-swwz4kzd	133	38	+	+	CC
cord-294366-swwz4kzd	133	39	T	t	NN
cord-294366-swwz4kzd	133	40	cells	cell	NNS
cord-294366-swwz4kzd	133	41	.	.	.
cord-294366-swwz4kzd	134	1	The	the	DT
cord-294366-swwz4kzd	134	2	development	development	NN
cord-294366-swwz4kzd	134	3	of	of	IN
cord-294366-swwz4kzd	134	4	pre	pre	JJ
cord-294366-swwz4kzd	134	5	-	-	JJ
cord-294366-swwz4kzd	134	6	and	and	CC
cord-294366-swwz4kzd	134	7	post	post	JJ
cord-294366-swwz4kzd	134	8	-	-	JJ
cord-294366-swwz4kzd	134	9	exposure	exposure	JJ
cord-294366-swwz4kzd	134	10	vaccines	vaccine	NNS
cord-294366-swwz4kzd	134	11	will	will	MD
cord-294366-swwz4kzd	134	12	likely	likely	RB
cord-294366-swwz4kzd	134	13	require	require	VB
cord-294366-swwz4kzd	134	14	antigens	antigen	NNS
cord-294366-swwz4kzd	134	15	expressed	express	VBN
cord-294366-swwz4kzd	134	16	by	by	IN
cord-294366-swwz4kzd	134	17	M.	M.	NNP
cord-294366-swwz4kzd	134	18	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	134	19	under	under	IN
cord-294366-swwz4kzd	134	20	pre	pre	JJ
cord-294366-swwz4kzd	134	21	-	-	JJ
cord-294366-swwz4kzd	134	22	and	and	CC
cord-294366-swwz4kzd	134	23	post	post	JJ
cord-294366-swwz4kzd	134	24	-	-	JJ
cord-294366-swwz4kzd	134	25	exposure	exposure	JJ
cord-294366-swwz4kzd	134	26	conditions	condition	NNS
cord-294366-swwz4kzd	134	27	,	,	,
cord-294366-swwz4kzd	134	28	respectively	respectively	RB
cord-294366-swwz4kzd	134	29	.	.	.
cord-294366-swwz4kzd	135	1	Interestingly	interestingly	RB
cord-294366-swwz4kzd	135	2	,	,	,
cord-294366-swwz4kzd	135	3	nonpolymorphic	nonpolymorphic	NNP
cord-294366-swwz4kzd	135	4	CD1	CD1	NNP
cord-294366-swwz4kzd	135	5	restricted	restrict	VBD
cord-294366-swwz4kzd	135	6	T	T	NNP
cord-294366-swwz4kzd	135	7	cells	cell	NNS
cord-294366-swwz4kzd	135	8	are	be	VBP
cord-294366-swwz4kzd	135	9	thought	think	VBN
cord-294366-swwz4kzd	135	10	to	to	TO
cord-294366-swwz4kzd	135	11	have	have	VB
cord-294366-swwz4kzd	135	12	evolved	evolve	VBN
cord-294366-swwz4kzd	135	13	as	as	IN
cord-294366-swwz4kzd	135	14	a	a	DT
cord-294366-swwz4kzd	135	15	result	result	NN
cord-294366-swwz4kzd	135	16	of	of	IN
cord-294366-swwz4kzd	135	17	prolonged	prolonged	JJ
cord-294366-swwz4kzd	135	18	interaction	interaction	NN
cord-294366-swwz4kzd	135	19	with	with	IN
cord-294366-swwz4kzd	135	20	mycobacteria	mycobacterium	NNS
cord-294366-swwz4kzd	135	21	,	,	,
cord-294366-swwz4kzd	135	22	indicating	indicate	VBG
cord-294366-swwz4kzd	135	23	the	the	DT
cord-294366-swwz4kzd	135	24	extent	extent	NN
cord-294366-swwz4kzd	135	25	of	of	IN
cord-294366-swwz4kzd	135	26	the	the	DT
cord-294366-swwz4kzd	135	27	impact	impact	NN
cord-294366-swwz4kzd	135	28	of	of	IN
cord-294366-swwz4kzd	135	29	mycobacteria	mycobacterium	NNS
cord-294366-swwz4kzd	135	30	on	on	IN
cord-294366-swwz4kzd	135	31	its	-PRON-	PRP$
cord-294366-swwz4kzd	135	32	mammalian	mammalian	JJ
cord-294366-swwz4kzd	135	33	host	host	NN
cord-294366-swwz4kzd	135	34	.	.	.
cord-294366-swwz4kzd	136	1	(	(	-LRB-
cord-294366-swwz4kzd	136	2	b	b	LS
cord-294366-swwz4kzd	136	3	)	)	-RRB-
cord-294366-swwz4kzd	136	4	For	for	IN
cord-294366-swwz4kzd	136	5	vaccines	vaccine	NNS
cord-294366-swwz4kzd	136	6	against	against	IN
cord-294366-swwz4kzd	136	7	HIV	HIV	NNP
cord-294366-swwz4kzd	136	8	,	,	,
cord-294366-swwz4kzd	136	9	it	-PRON-	PRP
cord-294366-swwz4kzd	136	10	seems	seem	VBZ
cord-294366-swwz4kzd	136	11	increasingly	increasingly	RB
cord-294366-swwz4kzd	136	12	likely	likely	JJ
cord-294366-swwz4kzd	136	13	that	that	IN
cord-294366-swwz4kzd	136	14	strategies	strategy	NNS
cord-294366-swwz4kzd	136	15	will	will	MD
cord-294366-swwz4kzd	136	16	depend	depend	VB
cord-294366-swwz4kzd	136	17	upon	upon	IN
cord-294366-swwz4kzd	136	18	highly	highly	RB
cord-294366-swwz4kzd	136	19	conserved	conserve	VBN
cord-294366-swwz4kzd	136	20	epitopes	epitope	NNS
cord-294366-swwz4kzd	136	21	and	and	CC
cord-294366-swwz4kzd	136	22	on	on	IN
cord-294366-swwz4kzd	136	23	vaccine	vaccine	NN
cord-294366-swwz4kzd	136	24	strategies	strategy	NNS
cord-294366-swwz4kzd	136	25	that	that	WDT
cord-294366-swwz4kzd	136	26	induce	induce	VBP
cord-294366-swwz4kzd	136	27	potent	potent	JJ
cord-294366-swwz4kzd	136	28	immune	immune	JJ
cord-294366-swwz4kzd	136	29	responses	response	NNS
cord-294366-swwz4kzd	136	30	capable	capable	JJ
cord-294366-swwz4kzd	136	31	of	of	IN
cord-294366-swwz4kzd	136	32	driving	drive	VBG
cord-294366-swwz4kzd	136	33	cytotoxicity	cytotoxicity	NN
cord-294366-swwz4kzd	136	34	,	,	,
cord-294366-swwz4kzd	136	35	as	as	RB
cord-294366-swwz4kzd	136	36	well	well	RB
cord-294366-swwz4kzd	136	37	as	as	IN
cord-294366-swwz4kzd	136	38	broadly	broadly	RB
cord-294366-swwz4kzd	136	39	reactive	reactive	JJ
cord-294366-swwz4kzd	136	40	,	,	,
cord-294366-swwz4kzd	136	41	highly	highly	RB
cord-294366-swwz4kzd	136	42	effective	effective	JJ
cord-294366-swwz4kzd	136	43	neutralizing	neutralize	VBG
cord-294366-swwz4kzd	136	44	antibodies	antibody	NNS
cord-294366-swwz4kzd	136	45	.	.	.
cord-294366-swwz4kzd	137	1	Target	target	NN
cord-294366-swwz4kzd	137	2	antigens	antigen	NNS
cord-294366-swwz4kzd	137	3	might	may	MD
cord-294366-swwz4kzd	137	4	very	very	RB
cord-294366-swwz4kzd	137	5	probably	probably	RB
cord-294366-swwz4kzd	137	6	be	be	VB
cord-294366-swwz4kzd	137	7	different	different	JJ
cord-294366-swwz4kzd	137	8	for	for	IN
cord-294366-swwz4kzd	137	9	each	each	DT
cord-294366-swwz4kzd	137	10	of	of	IN
cord-294366-swwz4kzd	137	11	these	these	DT
cord-294366-swwz4kzd	137	12	strategies	strategy	NNS
cord-294366-swwz4kzd	137	13	.	.	.
cord-294366-swwz4kzd	138	1	Figure	figure	NN
cord-294366-swwz4kzd	138	2	adapted	adapt	VBN
cord-294366-swwz4kzd	138	3	,	,	,
cord-294366-swwz4kzd	138	4	with	with	IN
cord-294366-swwz4kzd	138	5	permission	permission	NN
cord-294366-swwz4kzd	138	6	,	,	,
cord-294366-swwz4kzd	138	7	from	from	IN
cord-294366-swwz4kzd	138	8	Ref	Ref	NNP
cord-294366-swwz4kzd	138	9	.	.	.
cord-294366-swwz4kzd	139	1	[	[	-LRB-
cord-294366-swwz4kzd	139	2	32	32	CD
cord-294366-swwz4kzd	139	3	]	]	-RRB-
cord-294366-swwz4kzd	139	4	.	.	.
cord-294366-swwz4kzd	140	1	Adsorption	adsorption	NN
cord-294366-swwz4kzd	140	2	of	of	IN
cord-294366-swwz4kzd	140	3	antigens	antigen	NNS
cord-294366-swwz4kzd	140	4	;	;	:
cord-294366-swwz4kzd	140	5	maintaining	maintain	VBG
cord-294366-swwz4kzd	140	6	conformational	conformational	JJ
cord-294366-swwz4kzd	140	7	integrity	integrity	NN
cord-294366-swwz4kzd	140	8	with	with	IN
cord-294366-swwz4kzd	140	9	host	host	NN
cord-294366-swwz4kzd	140	10	polysialic	polysialic	JJ
cord-294366-swwz4kzd	140	11	acid	acid	NN
cord-294366-swwz4kzd	140	12	[	[	-LRB-
cord-294366-swwz4kzd	140	13	50	50	CD
cord-294366-swwz4kzd	140	14	]	]	-RRB-
cord-294366-swwz4kzd	140	15	.	.	.
cord-294366-swwz4kzd	141	1	In	in	IN
cord-294366-swwz4kzd	141	2	this	this	DT
cord-294366-swwz4kzd	141	3	case	case	NN
cord-294366-swwz4kzd	141	4	,	,	,
cord-294366-swwz4kzd	141	5	reverse	reverse	JJ
cord-294366-swwz4kzd	141	6	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	141	7	was	be	VBD
cord-294366-swwz4kzd	141	8	convincingly	convincingly	RB
cord-294366-swwz4kzd	141	9	applied	apply	VBN
cord-294366-swwz4kzd	141	10	to	to	TO
cord-294366-swwz4kzd	141	11	overcome	overcome	VB
cord-294366-swwz4kzd	141	12	these	these	DT
cord-294366-swwz4kzd	141	13	problems	problem	NNS
cord-294366-swwz4kzd	141	14	by	by	IN
cord-294366-swwz4kzd	141	15	alternative	alternative	JJ
cord-294366-swwz4kzd	141	16	means	mean	NNS
cord-294366-swwz4kzd	141	17	[	[	-LRB-
cord-294366-swwz4kzd	141	18	51	51	CD
cord-294366-swwz4kzd	141	19	]	]	-RRB-
cord-294366-swwz4kzd	141	20	.	.	.
cord-294366-swwz4kzd	142	1	Screening	screening	NN
cord-294366-swwz4kzd	142	2	of	of	IN
cord-294366-swwz4kzd	142	3	DNA	dna	NN
cord-294366-swwz4kzd	142	4	fragments	fragment	NNS
cord-294366-swwz4kzd	142	5	,	,	,
cord-294366-swwz4kzd	142	6	discarding	discard	VBG
cord-294366-swwz4kzd	142	7	likely	likely	JJ
cord-294366-swwz4kzd	142	8	cytoplasmic	cytoplasmic	JJ
cord-294366-swwz4kzd	142	9	protein	protein	NN
cord-294366-swwz4kzd	142	10	sequences	sequence	NNS
cord-294366-swwz4kzd	142	11	and	and	CC
cord-294366-swwz4kzd	142	12	known	know	VBN
cord-294366-swwz4kzd	142	13	Neisseria	Neisseria	NNP
cord-294366-swwz4kzd	142	14	antigens	antigen	NNS
cord-294366-swwz4kzd	142	15	,	,	,
cord-294366-swwz4kzd	142	16	extensive	extensive	JJ
cord-294366-swwz4kzd	142	17	cloning	cloning	NN
cord-294366-swwz4kzd	142	18	and	and	CC
cord-294366-swwz4kzd	142	19	expression	expression	NN
cord-294366-swwz4kzd	142	20	of	of	IN
cord-294366-swwz4kzd	142	21	identified	identify	VBN
cord-294366-swwz4kzd	142	22	candidate	candidate	NN
cord-294366-swwz4kzd	142	23	genes	gene	NNS
cord-294366-swwz4kzd	142	24	allowed	allow	VBD
cord-294366-swwz4kzd	142	25	selection	selection	NN
cord-294366-swwz4kzd	142	26	of	of	IN
cord-294366-swwz4kzd	142	27	antigens	antigen	NNS
cord-294366-swwz4kzd	142	28	that	that	WDT
cord-294366-swwz4kzd	142	29	were	be	VBD
cord-294366-swwz4kzd	142	30	found	find	VBN
cord-294366-swwz4kzd	142	31	not	not	RB
cord-294366-swwz4kzd	142	32	only	only	RB
cord-294366-swwz4kzd	142	33	to	to	TO
cord-294366-swwz4kzd	142	34	offer	offer	VB
cord-294366-swwz4kzd	142	35	significant	significant	JJ
cord-294366-swwz4kzd	142	36	potential	potential	NN
cord-294366-swwz4kzd	142	37	for	for	IN
cord-294366-swwz4kzd	142	38	protection	protection	NN
cord-294366-swwz4kzd	142	39	against	against	IN
cord-294366-swwz4kzd	142	40	group	group	NN
cord-294366-swwz4kzd	142	41	B	B	NNP
cord-294366-swwz4kzd	142	42	meningococcus	meningococcus	NNP
cord-294366-swwz4kzd	142	43	but	but	CC
cord-294366-swwz4kzd	142	44	also	also	RB
cord-294366-swwz4kzd	142	45	to	to	TO
cord-294366-swwz4kzd	142	46	facilitate	facilitate	VB
cord-294366-swwz4kzd	142	47	crossprotection	crossprotection	NN
cord-294366-swwz4kzd	142	48	against	against	IN
cord-294366-swwz4kzd	142	49	heterologous	heterologous	JJ
cord-294366-swwz4kzd	142	50	strains	strain	NNS
cord-294366-swwz4kzd	142	51	.	.	.
cord-294366-swwz4kzd	143	1	Also	also	RB
cord-294366-swwz4kzd	143	2	worth	worth	JJ
cord-294366-swwz4kzd	143	3	mentioning	mention	VBG
cord-294366-swwz4kzd	143	4	is	be	VBZ
cord-294366-swwz4kzd	143	5	the	the	DT
cord-294366-swwz4kzd	143	6	technique	technique	NN
cord-294366-swwz4kzd	143	7	of	of	IN
cord-294366-swwz4kzd	143	8	molecular	molecular	JJ
cord-294366-swwz4kzd	143	9	breeding	breeding	NN
cord-294366-swwz4kzd	143	10	or	or	CC
cord-294366-swwz4kzd	143	11	gene	gene	NN
cord-294366-swwz4kzd	143	12	shuffling	shuffling	NN
cord-294366-swwz4kzd	143	13	,	,	,
cord-294366-swwz4kzd	143	14	where	where	WRB
cord-294366-swwz4kzd	143	15	reassembled	reassemble	VBN
cord-294366-swwz4kzd	143	16	chimeric	chimeric	JJ
cord-294366-swwz4kzd	143	17	genes	gene	NNS
cord-294366-swwz4kzd	143	18	are	be	VBP
cord-294366-swwz4kzd	143	19	created	create	VBN
cord-294366-swwz4kzd	143	20	from	from	IN
cord-294366-swwz4kzd	143	21	a	a	DT
cord-294366-swwz4kzd	143	22	selection	selection	NN
cord-294366-swwz4kzd	143	23	of	of	IN
cord-294366-swwz4kzd	143	24	homologous	homologous	JJ
cord-294366-swwz4kzd	143	25	gene	gene	NN
cord-294366-swwz4kzd	143	26	sequences	sequence	NNS
cord-294366-swwz4kzd	143	27	.	.	.
cord-294366-swwz4kzd	144	1	The	the	DT
cord-294366-swwz4kzd	144	2	related	related	JJ
cord-294366-swwz4kzd	144	3	sequences	sequence	NNS
cord-294366-swwz4kzd	144	4	are	be	VBP
cord-294366-swwz4kzd	144	5	denatured	denature	VBN
cord-294366-swwz4kzd	144	6	,	,	,
cord-294366-swwz4kzd	144	7	annealed	anneal	VBN
cord-294366-swwz4kzd	144	8	and	and	CC
cord-294366-swwz4kzd	144	9	subsequently	subsequently	RB
cord-294366-swwz4kzd	144	10	extended	extend	VBN
cord-294366-swwz4kzd	144	11	in	in	IN
cord-294366-swwz4kzd	144	12	what	what	WP
cord-294366-swwz4kzd	144	13	is	be	VBZ
cord-294366-swwz4kzd	144	14	in	in	IN
cord-294366-swwz4kzd	144	15	effect	effect	NN
cord-294366-swwz4kzd	144	16	a	a	DT
cord-294366-swwz4kzd	144	17	self	self	NN
cord-294366-swwz4kzd	144	18	-	-	HYPH
cord-294366-swwz4kzd	144	19	priming	prime	VBG
cord-294366-swwz4kzd	144	20	polymerase	polymerase	NN
cord-294366-swwz4kzd	144	21	chain	chain	NN
cord-294366-swwz4kzd	144	22	reaction	reaction	NN
cord-294366-swwz4kzd	144	23	(	(	-LRB-
cord-294366-swwz4kzd	144	24	PCR	PCR	NNP
cord-294366-swwz4kzd	144	25	)	)	-RRB-
cord-294366-swwz4kzd	144	26	that	that	WDT
cord-294366-swwz4kzd	144	27	takes	take	VBZ
cord-294366-swwz4kzd	144	28	advantage	advantage	NN
cord-294366-swwz4kzd	144	29	of	of	IN
cord-294366-swwz4kzd	144	30	crossovers	crossover	NNS
cord-294366-swwz4kzd	144	31	,	,	,
cord-294366-swwz4kzd	144	32	deletions	deletion	NNS
cord-294366-swwz4kzd	144	33	,	,	,
cord-294366-swwz4kzd	144	34	insertions	insertion	NNS
cord-294366-swwz4kzd	144	35	,	,	,
cord-294366-swwz4kzd	144	36	inversions	inversion	NNS
cord-294366-swwz4kzd	144	37	and	and	CC
cord-294366-swwz4kzd	144	38	point	point	NN
cord-294366-swwz4kzd	144	39	mutations	mutation	NNS
cord-294366-swwz4kzd	144	40	,	,	,
cord-294366-swwz4kzd	144	41	as	as	IN
cord-294366-swwz4kzd	144	42	occurs	occur	NNS
cord-294366-swwz4kzd	144	43	in	in	IN
cord-294366-swwz4kzd	144	44	natural	natural	JJ
cord-294366-swwz4kzd	144	45	evolution	evolution	NN
cord-294366-swwz4kzd	144	46	(	(	-LRB-
cord-294366-swwz4kzd	144	47	hence	hence	RB
cord-294366-swwz4kzd	144	48	the	the	DT
cord-294366-swwz4kzd	144	49	term	term	NN
cord-294366-swwz4kzd	144	50	'	'	``
cord-294366-swwz4kzd	144	51	molecular	molecular	JJ
cord-294366-swwz4kzd	144	52	breeding	breeding	NN
cord-294366-swwz4kzd	144	53	'	'	''
cord-294366-swwz4kzd	144	54	)	)	-RRB-
cord-294366-swwz4kzd	144	55	.	.	.
cord-294366-swwz4kzd	145	1	Proteins	protein	NNS
cord-294366-swwz4kzd	145	2	and	and	CC
cord-294366-swwz4kzd	145	3	genes	gene	NNS
cord-294366-swwz4kzd	145	4	with	with	IN
cord-294366-swwz4kzd	145	5	enhanced	enhanced	JJ
cord-294366-swwz4kzd	145	6	activity	activity	NN
cord-294366-swwz4kzd	145	7	are	be	VBP
cord-294366-swwz4kzd	145	8	then	then	RB
cord-294366-swwz4kzd	145	9	selected	select	VBN
cord-294366-swwz4kzd	145	10	for	for	IN
cord-294366-swwz4kzd	145	11	inclusion	inclusion	NN
cord-294366-swwz4kzd	145	12	in	in	IN
cord-294366-swwz4kzd	145	13	further	further	JJ
cord-294366-swwz4kzd	145	14	rounds	round	NNS
cord-294366-swwz4kzd	145	15	of	of	IN
cord-294366-swwz4kzd	145	16	molecular	molecular	JJ
cord-294366-swwz4kzd	145	17	breeding	breeding	NN
cord-294366-swwz4kzd	145	18	.	.	.
cord-294366-swwz4kzd	146	1	This	this	DT
cord-294366-swwz4kzd	146	2	has	have	VBZ
cord-294366-swwz4kzd	146	3	a	a	DT
cord-294366-swwz4kzd	146	4	proven	prove	VBN
cord-294366-swwz4kzd	146	5	application	application	NN
cord-294366-swwz4kzd	146	6	for	for	IN
cord-294366-swwz4kzd	146	7	the	the	DT
cord-294366-swwz4kzd	146	8	generation	generation	NN
cord-294366-swwz4kzd	146	9	of	of	IN
cord-294366-swwz4kzd	146	10	enzymes	enzyme	NNS
cord-294366-swwz4kzd	146	11	with	with	IN
cord-294366-swwz4kzd	146	12	markedly	markedly	RB
cord-294366-swwz4kzd	146	13	enhanced	enhance	VBN
cord-294366-swwz4kzd	146	14	activity	activity	NN
cord-294366-swwz4kzd	146	15	[	[	-LRB-
cord-294366-swwz4kzd	146	16	52	52	CD
cord-294366-swwz4kzd	146	17	]	]	-RRB-
cord-294366-swwz4kzd	146	18	and	and	CC
cord-294366-swwz4kzd	146	19	the	the	DT
cord-294366-swwz4kzd	146	20	enhancement	enhancement	NN
cord-294366-swwz4kzd	146	21	of	of	IN
cord-294366-swwz4kzd	146	22	the	the	DT
cord-294366-swwz4kzd	146	23	functions	function	NNS
cord-294366-swwz4kzd	146	24	of	of	IN
cord-294366-swwz4kzd	146	25	a	a	DT
cord-294366-swwz4kzd	146	26	diverse	diverse	JJ
cord-294366-swwz4kzd	146	27	range	range	NN
cord-294366-swwz4kzd	146	28	of	of	IN
cord-294366-swwz4kzd	146	29	proteins	protein	NNS
cord-294366-swwz4kzd	146	30	,	,	,
cord-294366-swwz4kzd	146	31	such	such	JJ
cord-294366-swwz4kzd	146	32	as	as	IN
cord-294366-swwz4kzd	146	33	green	green	JJ
cord-294366-swwz4kzd	146	34	fluorescent	fluorescent	NN
cord-294366-swwz4kzd	146	35	protein	protein	NN
cord-294366-swwz4kzd	146	36	[	[	-LRB-
cord-294366-swwz4kzd	146	37	53	53	CD
cord-294366-swwz4kzd	146	38	]	]	-RRB-
cord-294366-swwz4kzd	146	39	and	and	CC
cord-294366-swwz4kzd	146	40	IFN	IFN	NNP
cord-294366-swwz4kzd	146	41	-	-	HYPH
cord-294366-swwz4kzd	146	42	α	α	NNP
cord-294366-swwz4kzd	146	43	[	[	-LRB-
cord-294366-swwz4kzd	146	44	54	54	CD
cord-294366-swwz4kzd	146	45	]	]	-RRB-
cord-294366-swwz4kzd	146	46	.	.	.
cord-294366-swwz4kzd	147	1	This	this	DT
cord-294366-swwz4kzd	147	2	technique	technique	NN
cord-294366-swwz4kzd	147	3	is	be	VBZ
cord-294366-swwz4kzd	147	4	thought	think	VBN
cord-294366-swwz4kzd	147	5	to	to	TO
cord-294366-swwz4kzd	147	6	be	be	VB
cord-294366-swwz4kzd	147	7	superior	superior	JJ
cord-294366-swwz4kzd	147	8	to	to	IN
cord-294366-swwz4kzd	147	9	other	other	JJ
cord-294366-swwz4kzd	147	10	methods	method	NNS
cord-294366-swwz4kzd	147	11	that	that	WDT
cord-294366-swwz4kzd	147	12	employ	employ	VBP
cord-294366-swwz4kzd	147	13	random	random	JJ
cord-294366-swwz4kzd	147	14	mutagenesis	mutagenesis	NN
cord-294366-swwz4kzd	147	15	,	,	,
cord-294366-swwz4kzd	147	16	such	such	JJ
cord-294366-swwz4kzd	147	17	as	as	IN
cord-294366-swwz4kzd	147	18	error	error	NN
cord-294366-swwz4kzd	147	19	-	-	HYPH
cord-294366-swwz4kzd	147	20	prone	prone	JJ
cord-294366-swwz4kzd	147	21	PCR	pcr	NN
cord-294366-swwz4kzd	147	22	(	(	-LRB-
cord-294366-swwz4kzd	147	23	hence	hence	RB
cord-294366-swwz4kzd	147	24	the	the	DT
cord-294366-swwz4kzd	147	25	phrase	phrase	NN
cord-294366-swwz4kzd	147	26	'	'	``
cord-294366-swwz4kzd	147	27	the	the	DT
cord-294366-swwz4kzd	147	28	rational	rational	JJ
cord-294366-swwz4kzd	147	29	basis	basis	NN
cord-294366-swwz4kzd	147	30	for	for	IN
cord-294366-swwz4kzd	147	31	irrational	irrational	JJ
cord-294366-swwz4kzd	147	32	design	design	NN
cord-294366-swwz4kzd	147	33	'	'	''
cord-294366-swwz4kzd	147	34	[	[	-LRB-
cord-294366-swwz4kzd	147	35	55	55	CD
cord-294366-swwz4kzd	147	36	]	]	-RRB-
cord-294366-swwz4kzd	147	37	)	)	-RRB-
cord-294366-swwz4kzd	147	38	,	,	,
cord-294366-swwz4kzd	147	39	but	but	CC
cord-294366-swwz4kzd	147	40	the	the	DT
cord-294366-swwz4kzd	147	41	screening	screening	NN
cord-294366-swwz4kzd	147	42	of	of	IN
cord-294366-swwz4kzd	147	43	candidate	candidate	NN
cord-294366-swwz4kzd	147	44	antigen	antigen	NN
cord-294366-swwz4kzd	147	45	genes	gene	NNS
cord-294366-swwz4kzd	147	46	is	be	VBZ
cord-294366-swwz4kzd	147	47	necessarily	necessarily	RB
cord-294366-swwz4kzd	147	48	expensive	expensive	JJ
cord-294366-swwz4kzd	147	49	in	in	IN
cord-294366-swwz4kzd	147	50	terms	term	NNS
cord-294366-swwz4kzd	147	51	of	of	IN
cord-294366-swwz4kzd	147	52	resources	resource	NNS
cord-294366-swwz4kzd	147	53	and	and	CC
cord-294366-swwz4kzd	147	54	time	time	NN
cord-294366-swwz4kzd	147	55	if	if	IN
cord-294366-swwz4kzd	147	56	it	-PRON-	PRP
cord-294366-swwz4kzd	147	57	is	be	VBZ
cord-294366-swwz4kzd	147	58	compared	compare	VBN
cord-294366-swwz4kzd	147	59	for	for	IN
cord-294366-swwz4kzd	147	60	example	example	NN
cord-294366-swwz4kzd	147	61	to	to	IN
cord-294366-swwz4kzd	147	62	the	the	DT
cord-294366-swwz4kzd	147	63	screening	screening	NN
cord-294366-swwz4kzd	147	64	of	of	IN
cord-294366-swwz4kzd	147	65	an	an	DT
cord-294366-swwz4kzd	147	66	enzyme	enzyme	NN
cord-294366-swwz4kzd	147	67	.	.	.
cord-294366-swwz4kzd	148	1	Their	-PRON-	PRP$
cord-294366-swwz4kzd	148	2	potential	potential	NN
cord-294366-swwz4kzd	148	3	has	have	VBZ
cord-294366-swwz4kzd	148	4	been	be	VBN
cord-294366-swwz4kzd	148	5	noted	note	VBN
cord-294366-swwz4kzd	148	6	with	with	IN
cord-294366-swwz4kzd	148	7	relevance	relevance	NN
cord-294366-swwz4kzd	148	8	to	to	IN
cord-294366-swwz4kzd	148	9	allergy	allergy	NN
cord-294366-swwz4kzd	148	10	vaccines	vaccine	NNS
cord-294366-swwz4kzd	148	11	[	[	-LRB-
cord-294366-swwz4kzd	148	12	56	56	CD
cord-294366-swwz4kzd	148	13	]	]	-RRB-
cord-294366-swwz4kzd	148	14	,	,	,
cord-294366-swwz4kzd	148	15	as	as	IN
cord-294366-swwz4kzd	148	16	pre	pre	JJ
cord-294366-swwz4kzd	148	17	-	-	JJ
cord-294366-swwz4kzd	148	18	existing	existing	JJ
cord-294366-swwz4kzd	148	19	immunity	immunity	NN
cord-294366-swwz4kzd	148	20	is	be	VBZ
cord-294366-swwz4kzd	148	21	the	the	DT
cord-294366-swwz4kzd	148	22	therapeutic	therapeutic	JJ
cord-294366-swwz4kzd	148	23	target	target	NN
cord-294366-swwz4kzd	148	24	and	and	CC
cord-294366-swwz4kzd	148	25	screening	screening	NN
cord-294366-swwz4kzd	148	26	of	of	IN
cord-294366-swwz4kzd	148	27	allergen	allergen	NN
cord-294366-swwz4kzd	148	28	variants	variant	NNS
cord-294366-swwz4kzd	148	29	might	may	MD
cord-294366-swwz4kzd	148	30	be	be	VB
cord-294366-swwz4kzd	148	31	somewhat	somewhat	RB
cord-294366-swwz4kzd	148	32	more	more	RBR
cord-294366-swwz4kzd	148	33	practicable	practicable	JJ
cord-294366-swwz4kzd	148	34	.	.	.
cord-294366-swwz4kzd	149	1	Bringing	bring	VBG
cord-294366-swwz4kzd	149	2	together	together	RB
cord-294366-swwz4kzd	149	3	developmental	developmental	JJ
cord-294366-swwz4kzd	149	4	strategies	strategy	NNS
cord-294366-swwz4kzd	149	5	with	with	IN
cord-294366-swwz4kzd	149	6	the	the	DT
cord-294366-swwz4kzd	149	7	knowledge	knowledge	NN
cord-294366-swwz4kzd	149	8	gleaned	glean	VBN
cord-294366-swwz4kzd	149	9	from	from	IN
cord-294366-swwz4kzd	149	10	host	host	NN
cord-294366-swwz4kzd	149	11	pathogen	pathogen	NN
cord-294366-swwz4kzd	149	12	interactions	interaction	NNS
cord-294366-swwz4kzd	149	13	represents	represent	VBZ
cord-294366-swwz4kzd	149	14	a	a	DT
cord-294366-swwz4kzd	149	15	highly	highly	RB
cord-294366-swwz4kzd	149	16	evolved	evolve	VBN
cord-294366-swwz4kzd	149	17	design	design	NN
cord-294366-swwz4kzd	149	18	strategy	strategy	NN
cord-294366-swwz4kzd	149	19	.	.	.
cord-294366-swwz4kzd	150	1	Although	although	IN
cord-294366-swwz4kzd	150	2	each	each	DT
cord-294366-swwz4kzd	150	3	individual	individual	JJ
cord-294366-swwz4kzd	150	4	molecular	molecular	JJ
cord-294366-swwz4kzd	150	5	biology	biology	NN
cord-294366-swwz4kzd	150	6	technique	technique	NN
cord-294366-swwz4kzd	150	7	appears	appear	VBZ
cord-294366-swwz4kzd	150	8	to	to	TO
cord-294366-swwz4kzd	150	9	have	have	VB
cord-294366-swwz4kzd	150	10	something	something	NN
cord-294366-swwz4kzd	150	11	to	to	TO
cord-294366-swwz4kzd	150	12	contribute	contribute	VB
cord-294366-swwz4kzd	150	13	to	to	IN
cord-294366-swwz4kzd	150	14	vaccine	vaccine	NN
cord-294366-swwz4kzd	150	15	development	development	NN
cord-294366-swwz4kzd	150	16	,	,	,
cord-294366-swwz4kzd	150	17	it	-PRON-	PRP
cord-294366-swwz4kzd	150	18	is	be	VBZ
cord-294366-swwz4kzd	150	19	the	the	DT
cord-294366-swwz4kzd	150	20	holistic	holistic	JJ
cord-294366-swwz4kzd	150	21	application	application	NN
cord-294366-swwz4kzd	150	22	of	of	IN
cord-294366-swwz4kzd	150	23	a	a	DT
cord-294366-swwz4kzd	150	24	combined	combine	VBN
cord-294366-swwz4kzd	150	25	approach	approach	NN
cord-294366-swwz4kzd	150	26	that	that	WDT
cord-294366-swwz4kzd	150	27	is	be	VBZ
cord-294366-swwz4kzd	150	28	closest	close	JJS
cord-294366-swwz4kzd	150	29	to	to	IN
cord-294366-swwz4kzd	150	30	a	a	DT
cord-294366-swwz4kzd	150	31	premeditated	premeditated	JJ
cord-294366-swwz4kzd	150	32	and	and	CC
cord-294366-swwz4kzd	150	33	planned	planned	JJ
cord-294366-swwz4kzd	150	34	rational	rational	JJ
cord-294366-swwz4kzd	150	35	vaccine	vaccine	NN
cord-294366-swwz4kzd	150	36	design	design	NN
cord-294366-swwz4kzd	150	37	.	.	.
cord-294366-swwz4kzd	151	1	Pathogens	pathogen	NNS
cord-294366-swwz4kzd	151	2	such	such	JJ
cord-294366-swwz4kzd	151	3	as	as	IN
cord-294366-swwz4kzd	151	4	Streptococcus	streptococcus	NN
cord-294366-swwz4kzd	151	5	pneumoniae	pneumoniae	NN
cord-294366-swwz4kzd	151	6	,	,	,
cord-294366-swwz4kzd	151	7	Porphyromonas	Porphyromonas	NNP
cord-294366-swwz4kzd	151	8	gingivalis	gingivalis	NNP
cord-294366-swwz4kzd	151	9	,	,	,
cord-294366-swwz4kzd	151	10	Staphylococcus	Staphylococcus	NNP
cord-294366-swwz4kzd	151	11	aureus	aureus	NN
cord-294366-swwz4kzd	151	12	,	,	,
cord-294366-swwz4kzd	151	13	Chlamydia	Chlamydia	NNP
cord-294366-swwz4kzd	151	14	pneumoniae	pneumoniae	NN
cord-294366-swwz4kzd	151	15	and	and	CC
cord-294366-swwz4kzd	151	16	Bacillus	Bacillus	NNP
cord-294366-swwz4kzd	151	17	anthracis	anthraci	NNS
cord-294366-swwz4kzd	151	18	have	have	VBP
cord-294366-swwz4kzd	151	19	all	all	DT
cord-294366-swwz4kzd	151	20	been	be	VBN
cord-294366-swwz4kzd	151	21	investigated	investigate	VBN
cord-294366-swwz4kzd	151	22	using	use	VBG
cord-294366-swwz4kzd	151	23	bioinformatics	bioinformatics	NN
cord-294366-swwz4kzd	151	24	techniques	technique	NNS
cord-294366-swwz4kzd	151	25	in	in	IN
cord-294366-swwz4kzd	151	26	the	the	DT
cord-294366-swwz4kzd	151	27	context	context	NN
cord-294366-swwz4kzd	151	28	of	of	IN
cord-294366-swwz4kzd	151	29	reverse	reverse	JJ
cord-294366-swwz4kzd	151	30	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	151	31	[	[	-LRB-
cord-294366-swwz4kzd	151	32	43	43	CD
cord-294366-swwz4kzd	151	33	]	]	-RRB-
cord-294366-swwz4kzd	151	34	,	,	,
cord-294366-swwz4kzd	151	35	with	with	IN
cord-294366-swwz4kzd	151	36	continued	continued	JJ
cord-294366-swwz4kzd	151	37	interesting	interesting	JJ
cord-294366-swwz4kzd	151	38	results	result	NNS
cord-294366-swwz4kzd	151	39	.	.	.
cord-294366-swwz4kzd	152	1	In	in	IN
cord-294366-swwz4kzd	152	2	terms	term	NNS
cord-294366-swwz4kzd	152	3	of	of	IN
cord-294366-swwz4kzd	152	4	antigen	antigen	NN
cord-294366-swwz4kzd	152	5	identification	identification	NN
cord-294366-swwz4kzd	152	6	,	,	,
cord-294366-swwz4kzd	152	7	the	the	DT
cord-294366-swwz4kzd	152	8	National	National	NNP
cord-294366-swwz4kzd	152	9	Institute	Institute	NNP
cord-294366-swwz4kzd	152	10	of	of	IN
cord-294366-swwz4kzd	152	11	Allergy	Allergy	NNP
cord-294366-swwz4kzd	152	12	and	and	CC
cord-294366-swwz4kzd	152	13	Infectious	Infectious	NNP
cord-294366-swwz4kzd	152	14	Diseases	Diseases	NNPS
cord-294366-swwz4kzd	152	15	(	(	-LRB-
cord-294366-swwz4kzd	152	16	NIAID	NIAID	NNP
cord-294366-swwz4kzd	152	17	)	)	-RRB-
cord-294366-swwz4kzd	152	18	recently	recently	RB
cord-294366-swwz4kzd	152	19	announced	announce	VBD
cord-294366-swwz4kzd	152	20	initiation	initiation	NN
cord-294366-swwz4kzd	152	21	of	of	IN
cord-294366-swwz4kzd	152	22	the	the	DT
cord-294366-swwz4kzd	152	23	Large	large	JJ
cord-294366-swwz4kzd	152	24	-	-	HYPH
cord-294366-swwz4kzd	152	25	Scale	Scale	NNP
cord-294366-swwz4kzd	152	26	Antibody	Antibody	NNP
cord-294366-swwz4kzd	152	27	and	and	CC
cord-294366-swwz4kzd	152	28	T	T	NNP
cord-294366-swwz4kzd	152	29	Cell	Cell	NNP
cord-294366-swwz4kzd	152	30	Epitope	Epitope	NNP
cord-294366-swwz4kzd	152	31	Discovery	Discovery	NNP
cord-294366-swwz4kzd	152	32	Program	Program	NNP
cord-294366-swwz4kzd	152	33	;	;	:
cord-294366-swwz4kzd	152	34	utilizing	utilize	VBG
cord-294366-swwz4kzd	152	35	complementary	complementary	JJ
cord-294366-swwz4kzd	152	36	methods	method	NNS
cord-294366-swwz4kzd	152	37	for	for	IN
cord-294366-swwz4kzd	152	38	epitope	epitope	NN
cord-294366-swwz4kzd	152	39	discovery	discovery	NN
cord-294366-swwz4kzd	152	40	,	,	,
cord-294366-swwz4kzd	152	41	it	-PRON-	PRP
cord-294366-swwz4kzd	152	42	is	be	VBZ
cord-294366-swwz4kzd	152	43	designed	design	VBN
cord-294366-swwz4kzd	152	44	to	to	TO
cord-294366-swwz4kzd	152	45	identify	identify	VB
cord-294366-swwz4kzd	152	46	immune	immune	JJ
cord-294366-swwz4kzd	152	47	epitopes	epitope	NNS
cord-294366-swwz4kzd	152	48	from	from	IN
cord-294366-swwz4kzd	152	49	selected	select	VBN
cord-294366-swwz4kzd	152	50	infectious	infectious	JJ
cord-294366-swwz4kzd	152	51	agents	agent	NNS
cord-294366-swwz4kzd	152	52	and	and	CC
cord-294366-swwz4kzd	152	53	will	will	MD
cord-294366-swwz4kzd	152	54	make	make	VB
cord-294366-swwz4kzd	152	55	this	this	DT
cord-294366-swwz4kzd	152	56	information	information	NN
cord-294366-swwz4kzd	152	57	freely	freely	RB
cord-294366-swwz4kzd	152	58	available	available	JJ
cord-294366-swwz4kzd	152	59	to	to	IN
cord-294366-swwz4kzd	152	60	scientists	scientist	NNS
cord-294366-swwz4kzd	152	61	worldwide	worldwide	RB
cord-294366-swwz4kzd	152	62	through	through	IN
cord-294366-swwz4kzd	152	63	the	the	DT
cord-294366-swwz4kzd	152	64	Immune	Immune	NNP
cord-294366-swwz4kzd	152	65	Epitope	Epitope	NNP
cord-294366-swwz4kzd	152	66	Database	Database	NNP
cord-294366-swwz4kzd	152	67	and	and	CC
cord-294366-swwz4kzd	152	68	Analysis	Analysis	NNP
cord-294366-swwz4kzd	152	69	Resource	Resource	NNP
cord-294366-swwz4kzd	152	70	(	(	-LRB-
cord-294366-swwz4kzd	152	71	IEDB	IEDB	NNP
cord-294366-swwz4kzd	152	72	)	)	-RRB-
cord-294366-swwz4kzd	152	73	,	,	,
cord-294366-swwz4kzd	152	74	currently	currently	RB
cord-294366-swwz4kzd	152	75	under	under	IN
cord-294366-swwz4kzd	152	76	development	development	NN
cord-294366-swwz4kzd	152	77	[	[	-LRB-
cord-294366-swwz4kzd	152	78	57	57	CD
cord-294366-swwz4kzd	152	79	]	]	-RRB-
cord-294366-swwz4kzd	152	80	.	.	.
cord-294366-swwz4kzd	153	1	Recent	recent	JJ
cord-294366-swwz4kzd	153	2	discoveries	discovery	NNS
cord-294366-swwz4kzd	153	3	have	have	VBP
cord-294366-swwz4kzd	153	4	resulted	result	VBN
cord-294366-swwz4kzd	153	5	in	in	IN
cord-294366-swwz4kzd	153	6	a	a	DT
cord-294366-swwz4kzd	153	7	wealth	wealth	NN
cord-294366-swwz4kzd	153	8	of	of	IN
cord-294366-swwz4kzd	153	9	options	option	NNS
cord-294366-swwz4kzd	153	10	,	,	,
cord-294366-swwz4kzd	153	11	when	when	WRB
cord-294366-swwz4kzd	153	12	considering	consider	VBG
cord-294366-swwz4kzd	153	13	what	what	WP
cord-294366-swwz4kzd	153	14	we	-PRON-	PRP
cord-294366-swwz4kzd	153	15	can	can	MD
cord-294366-swwz4kzd	153	16	do	do	VB
cord-294366-swwz4kzd	153	17	in	in	IN
cord-294366-swwz4kzd	153	18	terms	term	NNS
cord-294366-swwz4kzd	153	19	of	of	IN
cord-294366-swwz4kzd	153	20	vaccine	vaccine	NN
cord-294366-swwz4kzd	153	21	design	design	NN
cord-294366-swwz4kzd	153	22	and	and	CC
cord-294366-swwz4kzd	153	23	production	production	NN
cord-294366-swwz4kzd	153	24	.	.	.
cord-294366-swwz4kzd	154	1	Mechanisms	mechanism	NNS
cord-294366-swwz4kzd	154	2	of	of	IN
cord-294366-swwz4kzd	154	3	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	154	4	action	action	NN
cord-294366-swwz4kzd	154	5	have	have	VBP
cord-294366-swwz4kzd	154	6	been	be	VBN
cord-294366-swwz4kzd	154	7	elucidated	elucidate	VBN
cord-294366-swwz4kzd	154	8	,	,	,
cord-294366-swwz4kzd	154	9	pattern	pattern	NN
cord-294366-swwz4kzd	154	10	recognition	recognition	NN
cord-294366-swwz4kzd	154	11	receptors	receptor	NNS
cord-294366-swwz4kzd	154	12	including	include	VBG
cord-294366-swwz4kzd	154	13	Toll	Toll	NNP
cord-294366-swwz4kzd	154	14	-	-	HYPH
cord-294366-swwz4kzd	154	15	like	like	JJ
cord-294366-swwz4kzd	154	16	receptors	receptor	NNS
cord-294366-swwz4kzd	154	17	,	,	,
cord-294366-swwz4kzd	154	18	NOD1	NOD1	NNP
cord-294366-swwz4kzd	154	19	,	,	,
cord-294366-swwz4kzd	154	20	NOD2	NOD2	NNPS
cord-294366-swwz4kzd	154	21	,	,	,
cord-294366-swwz4kzd	154	22	scavenger	scavenger	NN
cord-294366-swwz4kzd	154	23	receptors	receptor	NNS
cord-294366-swwz4kzd	154	24	,	,	,
cord-294366-swwz4kzd	154	25	mannose	mannose	NN
cord-294366-swwz4kzd	154	26	and	and	CC
cord-294366-swwz4kzd	154	27	other	other	JJ
cord-294366-swwz4kzd	154	28	receptors	receptor	NNS
cord-294366-swwz4kzd	154	29	are	be	VBP
cord-294366-swwz4kzd	154	30	becoming	become	VBG
cord-294366-swwz4kzd	154	31	increasingly	increasingly	RB
cord-294366-swwz4kzd	154	32	well	well	RB
cord-294366-swwz4kzd	154	33	defined	define	VBN
cord-294366-swwz4kzd	154	34	[	[	-LRB-
cord-294366-swwz4kzd	154	35	38	38	CD
cord-294366-swwz4kzd	154	36	]	]	-RRB-
cord-294366-swwz4kzd	154	37	and	and	CC
cord-294366-swwz4kzd	154	38	intracellular	intracellular	JJ
cord-294366-swwz4kzd	154	39	events	event	NNS
cord-294366-swwz4kzd	154	40	related	relate	VBN
cord-294366-swwz4kzd	154	41	to	to	IN
cord-294366-swwz4kzd	154	42	these	these	DT
cord-294366-swwz4kzd	154	43	,	,	,
cord-294366-swwz4kzd	154	44	such	such	JJ
cord-294366-swwz4kzd	154	45	as	as	IN
cord-294366-swwz4kzd	154	46	activation	activation	NN
cord-294366-swwz4kzd	154	47	of	of	IN
cord-294366-swwz4kzd	154	48	transcription	transcription	NN
cord-294366-swwz4kzd	154	49	factors	factor	NNS
cord-294366-swwz4kzd	154	50	and	and	CC
cord-294366-swwz4kzd	154	51	expression	expression	NN
cord-294366-swwz4kzd	154	52	of	of	IN
cord-294366-swwz4kzd	154	53	inflammatory	inflammatory	JJ
cord-294366-swwz4kzd	154	54	cytokines	cytokine	NNS
cord-294366-swwz4kzd	154	55	,	,	,
cord-294366-swwz4kzd	154	56	shed	shed	VBP
cord-294366-swwz4kzd	154	57	further	further	JJ
cord-294366-swwz4kzd	154	58	light	light	NN
cord-294366-swwz4kzd	154	59	on	on	IN
cord-294366-swwz4kzd	154	60	how	how	WRB
cord-294366-swwz4kzd	154	61	these	these	DT
cord-294366-swwz4kzd	154	62	ligands	ligand	NNS
cord-294366-swwz4kzd	154	63	and	and	CC
cord-294366-swwz4kzd	154	64	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	154	65	that	that	WDT
cord-294366-swwz4kzd	154	66	bind	bind	VBP
cord-294366-swwz4kzd	154	67	to	to	TO
cord-294366-swwz4kzd	154	68	pattern	pattern	NN
cord-294366-swwz4kzd	154	69	recognition	recognition	NN
cord-294366-swwz4kzd	154	70	receptors	receptor	NNS
cord-294366-swwz4kzd	154	71	mediate	mediate	VBP
cord-294366-swwz4kzd	154	72	their	-PRON-	PRP$
cord-294366-swwz4kzd	154	73	immunological	immunological	JJ
cord-294366-swwz4kzd	154	74	actions	action	NNS
cord-294366-swwz4kzd	154	75	.	.	.
cord-294366-swwz4kzd	155	1	The	the	DT
cord-294366-swwz4kzd	155	2	ability	ability	NN
cord-294366-swwz4kzd	155	3	of	of	IN
cord-294366-swwz4kzd	155	4	infectious	infectious	JJ
cord-294366-swwz4kzd	155	5	agents	agent	NNS
cord-294366-swwz4kzd	155	6	to	to	TO
cord-294366-swwz4kzd	155	7	induce	induce	VB
cord-294366-swwz4kzd	155	8	rapid	rapid	JJ
cord-294366-swwz4kzd	155	9	,	,	,
cord-294366-swwz4kzd	155	10	innate	innate	JJ
cord-294366-swwz4kzd	155	11	immune	immune	JJ
cord-294366-swwz4kzd	155	12	responses	response	NNS
cord-294366-swwz4kzd	155	13	to	to	IN
cord-294366-swwz4kzd	155	14	molecular	molecular	JJ
cord-294366-swwz4kzd	155	15	patterns	pattern	NNS
cord-294366-swwz4kzd	155	16	provides	provide	VBZ
cord-294366-swwz4kzd	155	17	the	the	DT
cord-294366-swwz4kzd	155	18	basis	basis	NN
cord-294366-swwz4kzd	155	19	for	for	IN
cord-294366-swwz4kzd	155	20	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	155	21	immunotherapy	immunotherapy	NN
cord-294366-swwz4kzd	155	22	of	of	IN
cord-294366-swwz4kzd	155	23	cancers	cancer	NNS
cord-294366-swwz4kzd	155	24	.	.	.
cord-294366-swwz4kzd	156	1	Studies	study	NNS
cord-294366-swwz4kzd	156	2	,	,	,
cord-294366-swwz4kzd	156	3	such	such	JJ
cord-294366-swwz4kzd	156	4	as	as	IN
cord-294366-swwz4kzd	156	5	the	the	DT
cord-294366-swwz4kzd	156	6	recent	recent	JJ
cord-294366-swwz4kzd	156	7	work	work	NN
cord-294366-swwz4kzd	156	8	examining	examine	VBG
cord-294366-swwz4kzd	156	9	the	the	DT
cord-294366-swwz4kzd	156	10	adjuvant	adjuvant	JJ
cord-294366-swwz4kzd	156	11	activity	activity	NN
cord-294366-swwz4kzd	156	12	of	of	IN
cord-294366-swwz4kzd	156	13	BCG	BCG	NNP
cord-294366-swwz4kzd	156	14	cell	cell	NN
cord-294366-swwz4kzd	156	15	-	-	HYPH
cord-294366-swwz4kzd	156	16	wall	wall	NN
cord-294366-swwz4kzd	156	17	skeleton	skeleton	NN
cord-294366-swwz4kzd	156	18	,	,	,
cord-294366-swwz4kzd	156	19	peptidoglycan	peptidoglycan	NN
cord-294366-swwz4kzd	156	20	and	and	CC
cord-294366-swwz4kzd	156	21	lipopolysaccharide	lipopolysaccharide	NN
cord-294366-swwz4kzd	156	22	by	by	IN
cord-294366-swwz4kzd	156	23	the	the	DT
cord-294366-swwz4kzd	156	24	induction	induction	NN
cord-294366-swwz4kzd	156	25	of	of	IN
cord-294366-swwz4kzd	156	26	genes	gene	NNS
cord-294366-swwz4kzd	156	27	in	in	IN
cord-294366-swwz4kzd	156	28	dendritic	dendritic	JJ
cord-294366-swwz4kzd	156	29	cells	cell	NNS
cord-294366-swwz4kzd	156	30	[	[	-LRB-
cord-294366-swwz4kzd	156	31	58	58	CD
cord-294366-swwz4kzd	156	32	]	]	-RRB-
cord-294366-swwz4kzd	156	33	,	,	,
cord-294366-swwz4kzd	156	34	will	will	MD
cord-294366-swwz4kzd	156	35	very	very	RB
cord-294366-swwz4kzd	156	36	possibly	possibly	RB
cord-294366-swwz4kzd	156	37	help	help	VB
cord-294366-swwz4kzd	156	38	to	to	TO
cord-294366-swwz4kzd	156	39	achieve	achieve	VB
cord-294366-swwz4kzd	156	40	definition	definition	NN
cord-294366-swwz4kzd	156	41	of	of	IN
cord-294366-swwz4kzd	156	42	efficient	efficient	JJ
cord-294366-swwz4kzd	156	43	effector	effector	NN
cord-294366-swwz4kzd	156	44	output	output	NN
cord-294366-swwz4kzd	156	45	with	with	IN
cord-294366-swwz4kzd	156	46	minimal	minimal	JJ
cord-294366-swwz4kzd	156	47	toxicity	toxicity	NN
cord-294366-swwz4kzd	156	48	.	.	.
cord-294366-swwz4kzd	157	1	The	the	DT
cord-294366-swwz4kzd	157	2	easier	easy	JJR
cord-294366-swwz4kzd	157	3	and	and	CC
cord-294366-swwz4kzd	157	4	safer	safe	JJR
cord-294366-swwz4kzd	157	5	production	production	NN
cord-294366-swwz4kzd	157	6	of	of	IN
cord-294366-swwz4kzd	157	7	vaccines	vaccine	NNS
cord-294366-swwz4kzd	157	8	and	and	CC
cord-294366-swwz4kzd	157	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	157	10	components	component	NNS
cord-294366-swwz4kzd	157	11	facilitated	facilitate	VBN
cord-294366-swwz4kzd	157	12	by	by	IN
cord-294366-swwz4kzd	157	13	modern	modern	JJ
cord-294366-swwz4kzd	157	14	biological	biological	JJ
cord-294366-swwz4kzd	157	15	techniques	technique	NNS
cord-294366-swwz4kzd	157	16	underpins	underpin	VBZ
cord-294366-swwz4kzd	157	17	a	a	DT
cord-294366-swwz4kzd	157	18	rational	rational	JJ
cord-294366-swwz4kzd	157	19	approach	approach	NN
cord-294366-swwz4kzd	157	20	that	that	WDT
cord-294366-swwz4kzd	157	21	is	be	VBZ
cord-294366-swwz4kzd	157	22	an	an	DT
cord-294366-swwz4kzd	157	23	integral	integral	JJ
cord-294366-swwz4kzd	157	24	part	part	NN
cord-294366-swwz4kzd	157	25	of	of	IN
cord-294366-swwz4kzd	157	26	the	the	DT
cord-294366-swwz4kzd	157	27	rational	rational	JJ
cord-294366-swwz4kzd	157	28	design	design	NN
cord-294366-swwz4kzd	157	29	of	of	IN
cord-294366-swwz4kzd	157	30	vaccines	vaccine	NNS
cord-294366-swwz4kzd	157	31	.	.	.
cord-294366-swwz4kzd	158	1	The	the	DT
cord-294366-swwz4kzd	158	2	extensive	extensive	JJ
cord-294366-swwz4kzd	158	3	knowledge	knowledge	NN
cord-294366-swwz4kzd	158	4	of	of	IN
cord-294366-swwz4kzd	158	5	immunological	immunological	JJ
cord-294366-swwz4kzd	158	6	mechanisms	mechanism	NNS
cord-294366-swwz4kzd	158	7	and	and	CC
cord-294366-swwz4kzd	158	8	host	host	NN
cord-294366-swwz4kzd	158	9	pathogen	pathogen	NN
cord-294366-swwz4kzd	158	10	interactions	interaction	NNS
cord-294366-swwz4kzd	158	11	is	be	VBZ
cord-294366-swwz4kzd	158	12	able	able	JJ
cord-294366-swwz4kzd	158	13	to	to	TO
cord-294366-swwz4kzd	158	14	contribute	contribute	VB
cord-294366-swwz4kzd	158	15	to	to	IN
cord-294366-swwz4kzd	158	16	the	the	DT
cord-294366-swwz4kzd	158	17	design	design	NN
cord-294366-swwz4kzd	158	18	of	of	IN
cord-294366-swwz4kzd	158	19	effective	effective	JJ
cord-294366-swwz4kzd	158	20	vaccines	vaccine	NNS
cord-294366-swwz4kzd	158	21	in	in	IN
cord-294366-swwz4kzd	158	22	addition	addition	NN
cord-294366-swwz4kzd	158	23	to	to	IN
cord-294366-swwz4kzd	158	24	the	the	DT
cord-294366-swwz4kzd	158	25	elucidation	elucidation	NN
cord-294366-swwz4kzd	158	26	of	of	IN
cord-294366-swwz4kzd	158	27	the	the	DT
cord-294366-swwz4kzd	158	28	mechanisms	mechanism	NNS
cord-294366-swwz4kzd	158	29	of	of	IN
cord-294366-swwz4kzd	158	30	action	action	NN
cord-294366-swwz4kzd	158	31	of	of	IN
cord-294366-swwz4kzd	158	32	many	many	JJ
cord-294366-swwz4kzd	158	33	candidate	candidate	NN
cord-294366-swwz4kzd	158	34	vaccine	vaccine	NN
cord-294366-swwz4kzd	158	35	agents	agent	NNS
cord-294366-swwz4kzd	158	36	.	.	.
cord-294366-swwz4kzd	159	1	In	in	IN
cord-294366-swwz4kzd	159	2	fact	fact	NN
cord-294366-swwz4kzd	159	3	,	,	,
cord-294366-swwz4kzd	159	4	rational	rational	JJ
cord-294366-swwz4kzd	159	5	design	design	NN
cord-294366-swwz4kzd	159	6	of	of	IN
cord-294366-swwz4kzd	159	7	vaccines	vaccine	NNS
cord-294366-swwz4kzd	159	8	represents	represent	VBZ
cord-294366-swwz4kzd	159	9	a	a	DT
cord-294366-swwz4kzd	159	10	driving	drive	VBG
cord-294366-swwz4kzd	159	11	force	force	NN
cord-294366-swwz4kzd	159	12	born	bear	VBN
cord-294366-swwz4kzd	159	13	in	in	IN
cord-294366-swwz4kzd	159	14	the	the	DT
cord-294366-swwz4kzd	159	15	first	first	JJ
cord-294366-swwz4kzd	159	16	revelations	revelation	NNS
cord-294366-swwz4kzd	159	17	that	that	IN
cord-294366-swwz4kzd	159	18	components	component	NNS
cord-294366-swwz4kzd	159	19	from	from	IN
cord-294366-swwz4kzd	159	20	or	or	CC
cord-294366-swwz4kzd	159	21	relating	relate	VBG
cord-294366-swwz4kzd	159	22	to	to	IN
cord-294366-swwz4kzd	159	23	a	a	DT
cord-294366-swwz4kzd	159	24	microbial	microbial	JJ
cord-294366-swwz4kzd	159	25	pathogen	pathogen	NN
cord-294366-swwz4kzd	159	26	can	can	MD
cord-294366-swwz4kzd	159	27	be	be	VB
cord-294366-swwz4kzd	159	28	used	use	VBN
cord-294366-swwz4kzd	159	29	to	to	TO
cord-294366-swwz4kzd	159	30	protect	protect	VB
cord-294366-swwz4kzd	159	31	against	against	IN
cord-294366-swwz4kzd	159	32	that	that	DT
cord-294366-swwz4kzd	159	33	disease	disease	NN
cord-294366-swwz4kzd	159	34	and	and	CC
cord-294366-swwz4kzd	159	35	present	present	JJ
cord-294366-swwz4kzd	159	36	throughout	throughout	IN
cord-294366-swwz4kzd	159	37	development	development	NN
cord-294366-swwz4kzd	159	38	of	of	IN
cord-294366-swwz4kzd	159	39	vaccines	vaccine	NNS
cord-294366-swwz4kzd	159	40	in	in	IN
cord-294366-swwz4kzd	159	41	the	the	DT
cord-294366-swwz4kzd	159	42	modern	modern	JJ
cord-294366-swwz4kzd	159	43	era	era	NN
cord-294366-swwz4kzd	159	44	,	,	,
cord-294366-swwz4kzd	159	45	honing	hone	VBG
cord-294366-swwz4kzd	159	46	our	-PRON-	PRP$
cord-294366-swwz4kzd	159	47	understanding	understanding	NN
cord-294366-swwz4kzd	159	48	and	and	CC
cord-294366-swwz4kzd	159	49	preparing	prepare	VBG
cord-294366-swwz4kzd	159	50	the	the	DT
cord-294366-swwz4kzd	159	51	way	way	NN
cord-294366-swwz4kzd	159	52	for	for	IN
cord-294366-swwz4kzd	159	53	the	the	DT
cord-294366-swwz4kzd	159	54	next	next	JJ
cord-294366-swwz4kzd	159	55	steps	step	NNS
cord-294366-swwz4kzd	159	56	in	in	IN
cord-294366-swwz4kzd	159	57	the	the	DT
cord-294366-swwz4kzd	159	58	battle	battle	NN
cord-294366-swwz4kzd	159	59	to	to	TO
cord-294366-swwz4kzd	159	60	combat	combat	VB
cord-294366-swwz4kzd	159	61	today	today	NN
cord-294366-swwz4kzd	159	62	's	's	POS
cord-294366-swwz4kzd	159	63	significant	significant	JJ
cord-294366-swwz4kzd	159	64	pathogens	pathogen	NNS
cord-294366-swwz4kzd	159	65	and	and	CC
cord-294366-swwz4kzd	159	66	diseases	disease	NNS
cord-294366-swwz4kzd	159	67	,	,	,
cord-294366-swwz4kzd	159	68	such	such	JJ
cord-294366-swwz4kzd	159	69	as	as	IN
cord-294366-swwz4kzd	159	70	cancer	cancer	NN
cord-294366-swwz4kzd	159	71	,	,	,
cord-294366-swwz4kzd	159	72	HIV	HIV	NNP
cord-294366-swwz4kzd	159	73	,	,	,
cord-294366-swwz4kzd	159	74	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	159	75	and	and	CC
cord-294366-swwz4kzd	159	76	malaria	malaria	NN
cord-294366-swwz4kzd	159	77	.	.	.
cord-294366-swwz4kzd	160	1	In	in	IN
cord-294366-swwz4kzd	160	2	this	this	DT
cord-294366-swwz4kzd	160	3	era	era	NN
cord-294366-swwz4kzd	160	4	,	,	,
cord-294366-swwz4kzd	160	5	we	-PRON-	PRP
cord-294366-swwz4kzd	160	6	begin	begin	VBP
cord-294366-swwz4kzd	160	7	to	to	TO
cord-294366-swwz4kzd	160	8	explore	explore	VB
cord-294366-swwz4kzd	160	9	the	the	DT
cord-294366-swwz4kzd	160	10	very	very	JJ
cord-294366-swwz4kzd	160	11	limits	limit	NNS
cord-294366-swwz4kzd	160	12	of	of	IN
cord-294366-swwz4kzd	160	13	immunotherapeutic	immunotherapeutic	JJ
cord-294366-swwz4kzd	160	14	and	and	CC
cord-294366-swwz4kzd	160	15	prophylactic	prophylactic	JJ
cord-294366-swwz4kzd	160	16	intervention	intervention	NN
cord-294366-swwz4kzd	160	17	and	and	CC
cord-294366-swwz4kzd	160	18	the	the	DT
cord-294366-swwz4kzd	160	19	tools	tool	NNS
cord-294366-swwz4kzd	160	20	that	that	WDT
cord-294366-swwz4kzd	160	21	have	have	VBP
cord-294366-swwz4kzd	160	22	been	be	VBN
cord-294366-swwz4kzd	160	23	developed	develop	VBN
cord-294366-swwz4kzd	160	24	to	to	TO
cord-294366-swwz4kzd	160	25	elucidate	elucidate	VB
cord-294366-swwz4kzd	160	26	gene	gene	NN
cord-294366-swwz4kzd	160	27	expression	expression	NN
cord-294366-swwz4kzd	160	28	and	and	CC
cord-294366-swwz4kzd	160	29	function	function	NN
cord-294366-swwz4kzd	160	30	might	may	MD
cord-294366-swwz4kzd	160	31	have	have	VB
cord-294366-swwz4kzd	160	32	at	at	IN
cord-294366-swwz4kzd	160	33	last	last	JJ
cord-294366-swwz4kzd	160	34	begun	begin	VBN
cord-294366-swwz4kzd	160	35	to	to	TO
cord-294366-swwz4kzd	160	36	find	find	VB
cord-294366-swwz4kzd	160	37	their	-PRON-	PRP$
cord-294366-swwz4kzd	160	38	application	application	NN
cord-294366-swwz4kzd	160	39	in	in	IN
cord-294366-swwz4kzd	160	40	our	-PRON-	PRP$
cord-294366-swwz4kzd	160	41	most	most	RBS
cord-294366-swwz4kzd	160	42	significant	significant	JJ
cord-294366-swwz4kzd	160	43	of	of	IN
cord-294366-swwz4kzd	160	44	challenges	challenge	NNS
cord-294366-swwz4kzd	160	45	.	.	.
cord-294366-swwz4kzd	161	1	Anamnestic	anamnestic	JJ
cord-294366-swwz4kzd	161	2	response	response	NN
cord-294366-swwz4kzd	161	3	to	to	IN
cord-294366-swwz4kzd	161	4	administration	administration	NN
cord-294366-swwz4kzd	161	5	of	of	IN
cord-294366-swwz4kzd	161	6	purified	purify	VBN
cord-294366-swwz4kzd	161	7	non	non	JJ
cord-294366-swwz4kzd	161	8	-	-	JJ
cord-294366-swwz4kzd	161	9	adsorbed	adsorbed	JJ
cord-294366-swwz4kzd	161	10	hepatitis	hepatitis	NN
cord-294366-swwz4kzd	161	11	B	B	NNP
cord-294366-swwz4kzd	161	12	surface	surface	NN
cord-294366-swwz4kzd	161	13	antigen	antigen	NN
cord-294366-swwz4kzd	161	14	in	in	IN
cord-294366-swwz4kzd	161	15	healthy	healthy	JJ
cord-294366-swwz4kzd	161	16	responders	responder	NNS
cord-294366-swwz4kzd	161	17	to	to	IN
cord-294366-swwz4kzd	161	18	hepatitis	hepatitis	NNP
cord-294366-swwz4kzd	161	19	B	B	NNP
cord-294366-swwz4kzd	161	20	vaccine	vaccine	NN
cord-294366-swwz4kzd	161	21	with	with	IN
cord-294366-swwz4kzd	161	22	longterm	longterm	JJ
cord-294366-swwz4kzd	161	23	non	non	JJ
cord-294366-swwz4kzd	161	24	-	-	JJ
cord-294366-swwz4kzd	161	25	protective	protective	JJ
cord-294366-swwz4kzd	161	26	antibody	antibody	NN
cord-294366-swwz4kzd	161	27	titres	titre	NNS
cord-294366-swwz4kzd	161	28	The	the	DT
cord-294366-swwz4kzd	161	29	safety	safety	NN
cord-294366-swwz4kzd	161	30	,	,	,
cord-294366-swwz4kzd	161	31	reactogenicity	reactogenicity	NN
cord-294366-swwz4kzd	161	32	and	and	CC
cord-294366-swwz4kzd	161	33	immunogenicity	immunogenicity	NN
cord-294366-swwz4kzd	161	34	of	of	IN
cord-294366-swwz4kzd	161	35	a	a	DT
cord-294366-swwz4kzd	161	36	7-valent	7-valent	CD
cord-294366-swwz4kzd	161	37	pneumococcal	pneumococcal	JJ
cord-294366-swwz4kzd	161	38	conjugate	conjugate	NN
cord-294366-swwz4kzd	161	39	vaccine	vaccine	NN
cord-294366-swwz4kzd	161	40	(	(	-LRB-
cord-294366-swwz4kzd	161	41	7VPnC	7vpnc	LS
cord-294366-swwz4kzd	161	42	)	)	-RRB-
cord-294366-swwz4kzd	161	43	concurrently	concurrently	RB
cord-294366-swwz4kzd	161	44	administered	administer	VBN
cord-294366-swwz4kzd	161	45	with	with	IN
cord-294366-swwz4kzd	161	46	a	a	DT
cord-294366-swwz4kzd	161	47	combination	combination	NN
cord-294366-swwz4kzd	161	48	DTaP	dtap	NN
cord-294366-swwz4kzd	161	49	-	-	HYPH
cord-294366-swwz4kzd	161	50	IPV	IPV	NNP
cord-294366-swwz4kzd	161	51	-	-	HYPH
cord-294366-swwz4kzd	161	52	Hib	Hib	NNP
cord-294366-swwz4kzd	161	53	vaccine	vaccine	NN
cord-294366-swwz4kzd	161	54	Vaccines	vaccine	NNS
cord-294366-swwz4kzd	161	55	in	in	IN
cord-294366-swwz4kzd	161	56	the	the	DT
cord-294366-swwz4kzd	161	57	public	public	JJ
cord-294366-swwz4kzd	161	58	eye	eye	NN
cord-294366-swwz4kzd	161	59	Preparing	prepare	VBG
cord-294366-swwz4kzd	161	60	for	for	IN
cord-294366-swwz4kzd	161	61	the	the	DT
cord-294366-swwz4kzd	161	62	Next	Next	NNP
cord-294366-swwz4kzd	161	63	Pandemic	Pandemic	NNP
cord-294366-swwz4kzd	161	64	WHO	who	WP
cord-294366-swwz4kzd	161	65	's	be	VBZ
cord-294366-swwz4kzd	161	66	attempts	attempt	NNS
cord-294366-swwz4kzd	161	67	to	to	TO
cord-294366-swwz4kzd	161	68	eradicate	eradicate	VB
cord-294366-swwz4kzd	161	69	polio	polio	NN
cord-294366-swwz4kzd	161	70	are	be	VBP
cord-294366-swwz4kzd	161	71	thwarted	thwart	VBN
cord-294366-swwz4kzd	161	72	in	in	IN
cord-294366-swwz4kzd	161	73	Africa	Africa	NNP
cord-294366-swwz4kzd	161	74	and	and	CC
cord-294366-swwz4kzd	161	75	Asia	Asia	NNP
cord-294366-swwz4kzd	161	76	Spread	Spread	NNP
cord-294366-swwz4kzd	161	77	of	of	IN
cord-294366-swwz4kzd	161	78	vaccinederived	vaccinederived	JJ
cord-294366-swwz4kzd	161	79	poliovirus	poliovirus	NN
cord-294366-swwz4kzd	161	80	from	from	IN
cord-294366-swwz4kzd	161	81	a	a	DT
cord-294366-swwz4kzd	161	82	paralytic	paralytic	JJ
cord-294366-swwz4kzd	161	83	case	case	NN
cord-294366-swwz4kzd	161	84	in	in	IN
cord-294366-swwz4kzd	161	85	an	an	DT
cord-294366-swwz4kzd	161	86	immunodeficient	immunodeficient	JJ
cord-294366-swwz4kzd	161	87	child	child	NN
cord-294366-swwz4kzd	161	88	:	:	:
cord-294366-swwz4kzd	161	89	an	an	DT
cord-294366-swwz4kzd	161	90	insight	insight	NN
cord-294366-swwz4kzd	161	91	into	into	IN
cord-294366-swwz4kzd	161	92	the	the	DT
cord-294366-swwz4kzd	161	93	natural	natural	JJ
cord-294366-swwz4kzd	161	94	evolution	evolution	NN
cord-294366-swwz4kzd	161	95	of	of	IN
cord-294366-swwz4kzd	161	96	oral	oral	JJ
cord-294366-swwz4kzd	161	97	polio	polio	NN
cord-294366-swwz4kzd	161	98	vaccine	vaccine	NN
cord-294366-swwz4kzd	161	99	Long	long	JJ
cord-294366-swwz4kzd	161	100	-	-	HYPH
cord-294366-swwz4kzd	161	101	term	term	NN
cord-294366-swwz4kzd	161	102	excretion	excretion	NN
cord-294366-swwz4kzd	161	103	of	of	IN
cord-294366-swwz4kzd	161	104	vaccine	vaccine	NN
cord-294366-swwz4kzd	161	105	-	-	HYPH
cord-294366-swwz4kzd	161	106	derived	derive	VBN
cord-294366-swwz4kzd	161	107	poliovirus	poliovirus	NN
cord-294366-swwz4kzd	161	108	by	by	IN
cord-294366-swwz4kzd	161	109	a	a	DT
cord-294366-swwz4kzd	161	110	healthy	healthy	JJ
cord-294366-swwz4kzd	161	111	child	child	NN
cord-294366-swwz4kzd	161	112	Bacillus	Bacillus	NNP
cord-294366-swwz4kzd	161	113	Calmette	Calmette	NNP
cord-294366-swwz4kzd	161	114	-	-	HYPH
cord-294366-swwz4kzd	161	115	Guerin	Guerin	NNP
cord-294366-swwz4kzd	161	116	shares	share	NNS
cord-294366-swwz4kzd	161	117	with	with	IN
cord-294366-swwz4kzd	161	118	virulent	virulent	JJ
cord-294366-swwz4kzd	161	119	Mycobacterium	Mycobacterium	NNP
cord-294366-swwz4kzd	161	120	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	161	121	the	the	DT
cord-294366-swwz4kzd	161	122	capacity	capacity	NN
cord-294366-swwz4kzd	161	123	to	to	TO
cord-294366-swwz4kzd	161	124	subvert	subvert	VB
cord-294366-swwz4kzd	161	125	monocyte	monocyte	JJ
cord-294366-swwz4kzd	161	126	differentiation	differentiation	NN
cord-294366-swwz4kzd	161	127	into	into	IN
cord-294366-swwz4kzd	161	128	dendritic	dendritic	JJ
cord-294366-swwz4kzd	161	129	cell	cell	NN
cord-294366-swwz4kzd	161	130	:	:	:
cord-294366-swwz4kzd	161	131	implication	implication	NN
cord-294366-swwz4kzd	161	132	for	for	IN
cord-294366-swwz4kzd	161	133	its	-PRON-	PRP$
cord-294366-swwz4kzd	161	134	efficacy	efficacy	NN
cord-294366-swwz4kzd	161	135	as	as	IN
cord-294366-swwz4kzd	161	136	a	a	DT
cord-294366-swwz4kzd	161	137	vaccine	vaccine	NN
cord-294366-swwz4kzd	161	138	preventing	prevent	VBG
cord-294366-swwz4kzd	161	139	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	161	140	Autophagy	Autophagy	NNP
cord-294366-swwz4kzd	161	141	is	be	VBZ
cord-294366-swwz4kzd	161	142	a	a	DT
cord-294366-swwz4kzd	161	143	defense	defense	NN
cord-294366-swwz4kzd	161	144	mechanism	mechanism	NN
cord-294366-swwz4kzd	161	145	inhibiting	inhibit	VBG
cord-294366-swwz4kzd	161	146	BCG	BCG	NNP
cord-294366-swwz4kzd	161	147	and	and	CC
cord-294366-swwz4kzd	161	148	mycobacterium	mycobacterium	NN
cord-294366-swwz4kzd	161	149	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	161	150	survival	survival	NN
cord-294366-swwz4kzd	161	151	in	in	IN
cord-294366-swwz4kzd	161	152	infected	infected	JJ
cord-294366-swwz4kzd	161	153	macrophages	macrophage	NNS
cord-294366-swwz4kzd	161	154	BCG	bcg	NN
cord-294366-swwz4kzd	161	155	-	-	HYPH
cord-294366-swwz4kzd	161	156	different	different	JJ
cord-294366-swwz4kzd	161	157	strains	strain	NNS
cord-294366-swwz4kzd	161	158	,	,	,
cord-294366-swwz4kzd	161	159	different	different	JJ
cord-294366-swwz4kzd	161	160	vaccines	vaccine	NNS
cord-294366-swwz4kzd	161	161	?	?	.
cord-294366-swwz4kzd	162	1	Healthy	healthy	JJ
cord-294366-swwz4kzd	162	2	individuals	individual	NNS
cord-294366-swwz4kzd	162	3	that	that	WDT
cord-294366-swwz4kzd	162	4	control	control	VBP
cord-294366-swwz4kzd	162	5	a	a	DT
cord-294366-swwz4kzd	162	6	latent	latent	JJ
cord-294366-swwz4kzd	162	7	infection	infection	NN
cord-294366-swwz4kzd	162	8	with	with	IN
cord-294366-swwz4kzd	162	9	mycobacterium	mycobacterium	NNP
cord-294366-swwz4kzd	162	10	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	162	11	express	express	VBP
cord-294366-swwz4kzd	162	12	high	high	JJ
cord-294366-swwz4kzd	162	13	levels	level	NNS
cord-294366-swwz4kzd	162	14	of	of	IN
cord-294366-swwz4kzd	162	15	Th1	th1	NN
cord-294366-swwz4kzd	162	16	cytokines	cytokine	NNS
cord-294366-swwz4kzd	162	17	and	and	CC
cord-294366-swwz4kzd	162	18	the	the	DT
cord-294366-swwz4kzd	162	19	IL-4	IL-4	NNP
cord-294366-swwz4kzd	162	20	antagonist	antagonist	NN
cord-294366-swwz4kzd	163	1	IL-4δ2	IL-4δ2	NNP
cord-294366-swwz4kzd	163	2	Disseminated	disseminate	VBD
cord-294366-swwz4kzd	163	3	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	163	4	in	in	IN
cord-294366-swwz4kzd	163	5	interferon	interferon	NN
cord-294366-swwz4kzd	163	6	gamma	gamma	NNP
cord-294366-swwz4kzd	163	7	genedisrupted	genedisrupted	NNP
cord-294366-swwz4kzd	163	8	mice	mice	NNP
cord-294366-swwz4kzd	164	1	An	an	DT
cord-294366-swwz4kzd	164	2	essential	essential	JJ
cord-294366-swwz4kzd	164	3	role	role	NN
cord-294366-swwz4kzd	164	4	for	for	IN
cord-294366-swwz4kzd	164	5	interferon	interferon	NN
cord-294366-swwz4kzd	164	6	gamma	gamma	NN
cord-294366-swwz4kzd	164	7	in	in	IN
cord-294366-swwz4kzd	164	8	resistance	resistance	NN
cord-294366-swwz4kzd	164	9	to	to	IN
cord-294366-swwz4kzd	164	10	Mycobacterium	Mycobacterium	NNP
cord-294366-swwz4kzd	164	11	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	164	12	infection	infection	NN
cord-294366-swwz4kzd	164	13	Positive	positive	JJ
cord-294366-swwz4kzd	164	14	selection	selection	NN
cord-294366-swwz4kzd	164	15	of	of	IN
cord-294366-swwz4kzd	164	16	HIV-1	HIV-1	NNP
cord-294366-swwz4kzd	164	17	cytotoxic	cytotoxic	JJ
cord-294366-swwz4kzd	164	18	T	t	NN
cord-294366-swwz4kzd	164	19	lymphocyte	lymphocyte	NN
cord-294366-swwz4kzd	164	20	escape	escape	NN
cord-294366-swwz4kzd	164	21	variants	variant	NNS
cord-294366-swwz4kzd	164	22	during	during	IN
cord-294366-swwz4kzd	164	23	primary	primary	JJ
cord-294366-swwz4kzd	164	24	infection	infection	NN
cord-294366-swwz4kzd	164	25	Requirement	Requirement	NNP
cord-294366-swwz4kzd	164	26	of	of	IN
cord-294366-swwz4kzd	164	27	diverse	diverse	JJ
cord-294366-swwz4kzd	164	28	T	t	NN
cord-294366-swwz4kzd	164	29	-	-	HYPH
cord-294366-swwz4kzd	164	30	helper	helper	NN
cord-294366-swwz4kzd	164	31	responses	response	NNS
cord-294366-swwz4kzd	164	32	elicited	elicit	VBN
cord-294366-swwz4kzd	164	33	by	by	IN
cord-294366-swwz4kzd	164	34	HIV	HIV	NNP
cord-294366-swwz4kzd	164	35	vaccines	vaccine	NNS
cord-294366-swwz4kzd	164	36	:	:	:
cord-294366-swwz4kzd	164	37	induction	induction	NN
cord-294366-swwz4kzd	164	38	of	of	IN
cord-294366-swwz4kzd	165	1	highly	highly	RB
cord-294366-swwz4kzd	165	2	targeted	target	VBN
cord-294366-swwz4kzd	165	3	humoral	humoral	JJ
cord-294366-swwz4kzd	165	4	and	and	CC
cord-294366-swwz4kzd	165	5	CTL	CTL	NNP
cord-294366-swwz4kzd	165	6	responses	response	NNS
cord-294366-swwz4kzd	165	7	T	t	NN
cord-294366-swwz4kzd	165	8	cells	cell	NNS
cord-294366-swwz4kzd	165	9	down	down	RB
cord-294366-swwz4kzd	165	10	-	-	HYPH
cord-294366-swwz4kzd	165	11	modulate	modulate	VB
cord-294366-swwz4kzd	165	12	peptide	peptide	NN
cord-294366-swwz4kzd	165	13	-	-	HYPH
cord-294366-swwz4kzd	165	14	MHC	MHC	NNP
cord-294366-swwz4kzd	165	15	complexes	complex	NNS
cord-294366-swwz4kzd	165	16	on	on	IN
cord-294366-swwz4kzd	165	17	APCs	apc	NNS
cord-294366-swwz4kzd	165	18	in	in	IN
cord-294366-swwz4kzd	165	19	vivo	vivo	FW
cord-294366-swwz4kzd	165	20	T	T	NNP
cord-294366-swwz4kzd	165	21	Cell	Cell	NNP
cord-294366-swwz4kzd	165	22	Regulation	Regulation	NNP
cord-294366-swwz4kzd	165	23	as	as	IN
cord-294366-swwz4kzd	165	24	a	a	DT
cord-294366-swwz4kzd	165	25	side	side	NN
cord-294366-swwz4kzd	165	26	effect	effect	NN
cord-294366-swwz4kzd	165	27	of	of	IN
cord-294366-swwz4kzd	165	28	homeostasis	homeostasis	NN
cord-294366-swwz4kzd	165	29	and	and	CC
cord-294366-swwz4kzd	165	30	competition	competition	NN
cord-294366-swwz4kzd	165	31	Recent	recent	JJ
cord-294366-swwz4kzd	165	32	findings	finding	NNS
cord-294366-swwz4kzd	165	33	on	on	IN
cord-294366-swwz4kzd	165	34	genes	gene	NNS
cord-294366-swwz4kzd	165	35	associated	associate	VBN
cord-294366-swwz4kzd	165	36	with	with	IN
cord-294366-swwz4kzd	165	37	inflammatory	inflammatory	JJ
cord-294366-swwz4kzd	165	38	disease	disease	NN
cord-294366-swwz4kzd	166	1	Peptidebased	peptidebased	JJ
cord-294366-swwz4kzd	166	2	therapeutic	therapeutic	JJ
cord-294366-swwz4kzd	166	3	vaccines	vaccine	NNS
cord-294366-swwz4kzd	166	4	for	for	IN
cord-294366-swwz4kzd	166	5	allergic	allergic	JJ
cord-294366-swwz4kzd	166	6	and	and	CC
cord-294366-swwz4kzd	166	7	autoimmune	autoimmune	JJ
cord-294366-swwz4kzd	166	8	diseases	disease	NNS
cord-294366-swwz4kzd	166	9	Analysis	Analysis	NNP
cord-294366-swwz4kzd	166	10	of	of	IN
cord-294366-swwz4kzd	166	11	the	the	DT
cord-294366-swwz4kzd	166	12	B	b	NN
cord-294366-swwz4kzd	166	13	-	-	HYPH
cord-294366-swwz4kzd	166	14	cell	cell	NN
cord-294366-swwz4kzd	166	15	repertoire	repertoire	NN
cord-294366-swwz4kzd	166	16	against	against	IN
cord-294366-swwz4kzd	166	17	antigens	antigen	NNS
cord-294366-swwz4kzd	166	18	expressed	express	VBN
cord-294366-swwz4kzd	166	19	by	by	IN
cord-294366-swwz4kzd	166	20	human	human	JJ
cord-294366-swwz4kzd	166	21	neoplasms	neoplasm	NNS
cord-294366-swwz4kzd	166	22	Paraneoplastic	Paraneoplastic	NNP
cord-294366-swwz4kzd	166	23	Syndromes	syndrome	NNS
cord-294366-swwz4kzd	166	24	Involving	involve	VBG
cord-294366-swwz4kzd	166	25	the	the	DT
cord-294366-swwz4kzd	166	26	Nervous	Nervous	NNP
cord-294366-swwz4kzd	166	27	System	System	NNP
cord-294366-swwz4kzd	166	28	DNA	dna	NN
cord-294366-swwz4kzd	166	29	vaccines	vaccine	NNS
cord-294366-swwz4kzd	166	30	to	to	TO
cord-294366-swwz4kzd	166	31	attack	attack	VB
cord-294366-swwz4kzd	166	32	cancer	cancer	NN
cord-294366-swwz4kzd	166	33	Anti	Anti	NNP
cord-294366-swwz4kzd	166	34	-	-	NNP
cord-294366-swwz4kzd	166	35	Hu	Hu	NNP
cord-294366-swwz4kzd	166	36	-	-	HYPH
cord-294366-swwz4kzd	166	37	associated	associate	VBN
cord-294366-swwz4kzd	166	38	paraneoplastic	paraneoplastic	JJ
cord-294366-swwz4kzd	166	39	encephalomyelitis	encephalomyelitis	NN
cord-294366-swwz4kzd	166	40	:	:	:
cord-294366-swwz4kzd	167	1	analysis	analysis	NN
cord-294366-swwz4kzd	167	2	of	of	IN
cord-294366-swwz4kzd	167	3	200	200	CD
cord-294366-swwz4kzd	167	4	patients	patient	NNS
cord-294366-swwz4kzd	167	5	Immunotherapy	Immunotherapy	NNP
cord-294366-swwz4kzd	167	6	and	and	CC
cord-294366-swwz4kzd	167	7	chemotherapy	chemotherapy	NN
cord-294366-swwz4kzd	167	8	-	-	:
cord-294366-swwz4kzd	167	9	a	a	DT
cord-294366-swwz4kzd	167	10	practical	practical	JJ
cord-294366-swwz4kzd	167	11	partnership	partnership	NN
cord-294366-swwz4kzd	167	12	Role	role	NN
cord-294366-swwz4kzd	167	13	of	of	IN
cord-294366-swwz4kzd	167	14	host	host	NN
cord-294366-swwz4kzd	167	15	antibody	antibody	NN
cord-294366-swwz4kzd	167	16	in	in	IN
cord-294366-swwz4kzd	167	17	the	the	DT
cord-294366-swwz4kzd	167	18	chemotherapeutic	chemotherapeutic	JJ
cord-294366-swwz4kzd	167	19	action	action	NN
cord-294366-swwz4kzd	167	20	of	of	IN
cord-294366-swwz4kzd	167	21	praziquantel	praziquantel	NN
cord-294366-swwz4kzd	167	22	against	against	IN
cord-294366-swwz4kzd	167	23	Schistosoma	Schistosoma	NNP
cord-294366-swwz4kzd	167	24	mansoni	mansoni	NNP
cord-294366-swwz4kzd	167	25	:	:	:
cord-294366-swwz4kzd	167	26	identification	identification	NN
cord-294366-swwz4kzd	167	27	of	of	IN
cord-294366-swwz4kzd	167	28	target	target	NN
cord-294366-swwz4kzd	167	29	antigens	antigen	NNS
cord-294366-swwz4kzd	167	30	Regulators	regulator	NNS
cord-294366-swwz4kzd	167	31	of	of	IN
cord-294366-swwz4kzd	167	32	apoptosis	apoptosis	NN
cord-294366-swwz4kzd	167	33	:	:	:
cord-294366-swwz4kzd	167	34	suitable	suitable	JJ
cord-294366-swwz4kzd	167	35	targets	target	NNS
cord-294366-swwz4kzd	167	36	for	for	IN
cord-294366-swwz4kzd	167	37	immune	immune	JJ
cord-294366-swwz4kzd	167	38	therapy	therapy	NN
cord-294366-swwz4kzd	167	39	of	of	IN
cord-294366-swwz4kzd	167	40	cancer	cancer	NN
cord-294366-swwz4kzd	167	41	Infectious	infectious	JJ
cord-294366-swwz4kzd	167	42	agents	agent	NNS
cord-294366-swwz4kzd	167	43	and	and	CC
cord-294366-swwz4kzd	167	44	cancer	cancer	NN
cord-294366-swwz4kzd	167	45	:	:	:
cord-294366-swwz4kzd	167	46	criteria	criterion	NNS
cord-294366-swwz4kzd	167	47	for	for	IN
cord-294366-swwz4kzd	167	48	a	a	DT
cord-294366-swwz4kzd	167	49	causal	causal	JJ
cord-294366-swwz4kzd	167	50	relation	relation	NN
cord-294366-swwz4kzd	167	51	Vaccines	vaccine	NNS
cord-294366-swwz4kzd	167	52	:	:	:
cord-294366-swwz4kzd	168	1	past	past	JJ
cord-294366-swwz4kzd	168	2	,	,	,
cord-294366-swwz4kzd	168	3	present	present	JJ
cord-294366-swwz4kzd	168	4	and	and	CC
cord-294366-swwz4kzd	168	5	future	future	JJ
cord-294366-swwz4kzd	168	6	Six	six	CD
cord-294366-swwz4kzd	168	7	revolutions	revolution	NNS
cord-294366-swwz4kzd	168	8	in	in	IN
cord-294366-swwz4kzd	168	9	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	168	10	Targeting	target	VBG
cord-294366-swwz4kzd	168	11	the	the	DT
cord-294366-swwz4kzd	168	12	innate	innate	JJ
cord-294366-swwz4kzd	168	13	immune	immune	JJ
cord-294366-swwz4kzd	168	14	response	response	NN
cord-294366-swwz4kzd	168	15	with	with	IN
cord-294366-swwz4kzd	168	16	improved	improved	JJ
cord-294366-swwz4kzd	168	17	vaccine	vaccine	NN
cord-294366-swwz4kzd	168	18	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	168	19	Particulate	particulate	VBP
cord-294366-swwz4kzd	168	20	delivery	delivery	NN
cord-294366-swwz4kzd	168	21	systems	system	NNS
cord-294366-swwz4kzd	168	22	for	for	IN
cord-294366-swwz4kzd	168	23	vaccines	vaccine	NNS
cord-294366-swwz4kzd	168	24	Particulate	Particulate	NNP
cord-294366-swwz4kzd	168	25	delivery	delivery	NN
cord-294366-swwz4kzd	168	26	systems	system	NNS
cord-294366-swwz4kzd	168	27	for	for	IN
cord-294366-swwz4kzd	168	28	biodefense	biodefense	NN
cord-294366-swwz4kzd	168	29	subunit	subunit	NN
cord-294366-swwz4kzd	168	30	vaccines	vaccine	NNS
cord-294366-swwz4kzd	168	31	Meeting	meet	VBG
cord-294366-swwz4kzd	168	32	on	on	IN
cord-294366-swwz4kzd	168	33	novel	novel	JJ
cord-294366-swwz4kzd	168	34	adjuvants	adjuvant	NNS
cord-294366-swwz4kzd	168	35	currently	currently	RB
cord-294366-swwz4kzd	168	36	in	in	IN
cord-294366-swwz4kzd	168	37	/	/	SYM
cord-294366-swwz4kzd	168	38	close	close	RB
cord-294366-swwz4kzd	168	39	to	to	IN
cord-294366-swwz4kzd	168	40	human	human	JJ
cord-294366-swwz4kzd	168	41	clinical	clinical	JJ
cord-294366-swwz4kzd	168	42	testing	testing	NN
cord-294366-swwz4kzd	168	43	:	:	:
cord-294366-swwz4kzd	168	44	World	World	NNP
cord-294366-swwz4kzd	168	45	Health	Health	NNP
cord-294366-swwz4kzd	168	46	Organization	Organization	NNP
cord-294366-swwz4kzd	168	47	-	-	HYPH
cord-294366-swwz4kzd	168	48	Organisation	Organisation	NNP
cord-294366-swwz4kzd	168	49	Mondiale	Mondiale	NNP
cord-294366-swwz4kzd	168	50	de	de	FW
cord-294366-swwz4kzd	168	51	la	la	NNP
cord-294366-swwz4kzd	168	52	Sante	Sante	NNP
cord-294366-swwz4kzd	168	53	Fondation	Fondation	NNP
cord-294366-swwz4kzd	168	54	Merieux	Merieux	NNP
cord-294366-swwz4kzd	168	55	Eradication	Eradication	NNP
cord-294366-swwz4kzd	168	56	and	and	CC
cord-294366-swwz4kzd	168	57	cessation	cessation	NN
cord-294366-swwz4kzd	168	58	of	of	IN
cord-294366-swwz4kzd	168	59	programmes	programme	NNS
cord-294366-swwz4kzd	168	60	:	:	:
cord-294366-swwz4kzd	168	61	vaccination	vaccination	NN
cord-294366-swwz4kzd	168	62	and	and	CC
cord-294366-swwz4kzd	168	63	public	public	JJ
cord-294366-swwz4kzd	168	64	health	health	NN
cord-294366-swwz4kzd	168	65	care	care	NN
cord-294366-swwz4kzd	168	66	A	a	DT
cord-294366-swwz4kzd	168	67	Vaccine	vaccine	NN
cord-294366-swwz4kzd	168	68	to	to	TO
cord-294366-swwz4kzd	168	69	prevent	prevent	VB
cord-294366-swwz4kzd	168	70	herpes	herpes	NN
cord-294366-swwz4kzd	168	71	zoster	zoster	NN
cord-294366-swwz4kzd	168	72	and	and	CC
cord-294366-swwz4kzd	168	73	postherpetic	postherpetic	NNP
cord-294366-swwz4kzd	168	74	neuralgia	neuralgia	NN
cord-294366-swwz4kzd	168	75	in	in	IN
cord-294366-swwz4kzd	168	76	older	old	JJR
cord-294366-swwz4kzd	168	77	adults	adult	NNS
cord-294366-swwz4kzd	168	78	Cancer	Cancer	NNP
cord-294366-swwz4kzd	168	79	therapy	therapy	NN
cord-294366-swwz4kzd	168	80	using	use	VBG
cord-294366-swwz4kzd	168	81	a	a	DT
cord-294366-swwz4kzd	168	82	self	self	NN
cord-294366-swwz4kzd	168	83	-	-	HYPH
cord-294366-swwz4kzd	168	84	replicating	replicate	VBG
cord-294366-swwz4kzd	168	85	RNA	RNA	NNP
cord-294366-swwz4kzd	168	86	vaccine	vaccine	NN
cord-294366-swwz4kzd	168	87	Toll	Toll	NNP
cord-294366-swwz4kzd	168	88	-	-	HYPH
cord-294366-swwz4kzd	168	89	like	like	JJ
cord-294366-swwz4kzd	168	90	receptor	receptor	NN
cord-294366-swwz4kzd	168	91	signalling	signalling	NN
cord-294366-swwz4kzd	169	1	Can	Can	MD
cord-294366-swwz4kzd	169	2	successful	successful	JJ
cord-294366-swwz4kzd	169	3	vaccines	vaccine	NNS
cord-294366-swwz4kzd	169	4	teach	teach	VB
cord-294366-swwz4kzd	169	5	us	-PRON-	PRP
cord-294366-swwz4kzd	169	6	how	how	WRB
cord-294366-swwz4kzd	169	7	to	to	TO
cord-294366-swwz4kzd	169	8	induce	induce	VB
cord-294366-swwz4kzd	169	9	efficient	efficient	JJ
cord-294366-swwz4kzd	169	10	protective	protective	JJ
cord-294366-swwz4kzd	169	11	immune	immune	JJ
cord-294366-swwz4kzd	169	12	responses	response	NNS
cord-294366-swwz4kzd	169	13	?	?	.
cord-294366-swwz4kzd	170	1	Current	current	JJ
cord-294366-swwz4kzd	170	2	status	status	NN
cord-294366-swwz4kzd	170	3	of	of	IN
cord-294366-swwz4kzd	170	4	DNA	dna	NN
cord-294366-swwz4kzd	170	5	vaccines	vaccine	NNS
cord-294366-swwz4kzd	170	6	and	and	CC
cord-294366-swwz4kzd	170	7	their	-PRON-	PRP$
cord-294366-swwz4kzd	170	8	route	route	NN
cord-294366-swwz4kzd	170	9	of	of	IN
cord-294366-swwz4kzd	170	10	administration	administration	NN
cord-294366-swwz4kzd	170	11	DNA	dna	NN
cord-294366-swwz4kzd	170	12	content	content	NN
cord-294366-swwz4kzd	170	13	analysis	analysis	NN
cord-294366-swwz4kzd	170	14	on	on	IN
cord-294366-swwz4kzd	170	15	microarrays	microarray	NNS
cord-294366-swwz4kzd	170	16	Biotechnology	Biotechnology	NNP
cord-294366-swwz4kzd	170	17	and	and	CC
cord-294366-swwz4kzd	170	18	vaccines	vaccine	NNS
cord-294366-swwz4kzd	170	19	:	:	:
cord-294366-swwz4kzd	170	20	application	application	NN
cord-294366-swwz4kzd	170	21	of	of	IN
cord-294366-swwz4kzd	170	22	functional	functional	JJ
cord-294366-swwz4kzd	170	23	genomics	genomic	NNS
cord-294366-swwz4kzd	170	24	to	to	IN
cord-294366-swwz4kzd	170	25	Neisseria	Neisseria	NNP
cord-294366-swwz4kzd	170	26	meningitidis	meningitidis	NN
cord-294366-swwz4kzd	170	27	and	and	CC
cord-294366-swwz4kzd	170	28	other	other	JJ
cord-294366-swwz4kzd	170	29	bacterial	bacterial	JJ
cord-294366-swwz4kzd	170	30	pathogens	pathogen	NNS
cord-294366-swwz4kzd	171	1	Reverse	reverse	JJ
cord-294366-swwz4kzd	171	2	vaccinology	vaccinology	NN
cord-294366-swwz4kzd	171	3	Annulling	annul	VBG
cord-294366-swwz4kzd	171	4	a	a	DT
cord-294366-swwz4kzd	171	5	dangerous	dangerous	JJ
cord-294366-swwz4kzd	171	6	liaison	liaison	NN
cord-294366-swwz4kzd	171	7	:	:	:
cord-294366-swwz4kzd	172	1	vaccination	vaccination	NN
cord-294366-swwz4kzd	172	2	strategies	strategy	NNS
cord-294366-swwz4kzd	172	3	against	against	IN
cord-294366-swwz4kzd	172	4	AIDS	AIDS	NNP
cord-294366-swwz4kzd	172	5	and	and	CC
cord-294366-swwz4kzd	172	6	tuberculosis	tuberculosis	NN
cord-294366-swwz4kzd	173	1	The	the	DT
cord-294366-swwz4kzd	173	2	caveolin-1	caveolin-1	NNP
cord-294366-swwz4kzd	173	3	binding	bind	VBG
cord-294366-swwz4kzd	173	4	domain	domain	NN
cord-294366-swwz4kzd	173	5	of	of	IN
cord-294366-swwz4kzd	173	6	HIV-1	HIV-1	NNP
cord-294366-swwz4kzd	173	7	glycoprotein	glycoprotein	NN
cord-294366-swwz4kzd	173	8	gp41	gp41	NNP
cord-294366-swwz4kzd	173	9	is	be	VBZ
cord-294366-swwz4kzd	173	10	an	an	DT
cord-294366-swwz4kzd	173	11	efficient	efficient	JJ
cord-294366-swwz4kzd	173	12	B	b	NN
cord-294366-swwz4kzd	173	13	cell	cell	NN
cord-294366-swwz4kzd	173	14	epitope	epitope	NN
cord-294366-swwz4kzd	173	15	vaccine	vaccine	NN
cord-294366-swwz4kzd	173	16	candidate	candidate	NN
cord-294366-swwz4kzd	173	17	against	against	IN
cord-294366-swwz4kzd	173	18	virus	virus	NN
cord-294366-swwz4kzd	173	19	infection	infection	NN
cord-294366-swwz4kzd	173	20	Access	Access	NNP
cord-294366-swwz4kzd	173	21	of	of	IN
cord-294366-swwz4kzd	173	22	antibody	antibody	NN
cord-294366-swwz4kzd	173	23	molecules	molecule	NNS
cord-294366-swwz4kzd	173	24	to	to	IN
cord-294366-swwz4kzd	173	25	the	the	DT
cord-294366-swwz4kzd	173	26	conserved	conserve	VBN
cord-294366-swwz4kzd	173	27	coreceptor	coreceptor	NN
cord-294366-swwz4kzd	173	28	binding	bind	VBG
cord-294366-swwz4kzd	173	29	site	site	NN
cord-294366-swwz4kzd	173	30	on	on	IN
cord-294366-swwz4kzd	173	31	glycoprotein	glycoprotein	NN
cord-294366-swwz4kzd	173	32	gp120	gp120	NNP
cord-294366-swwz4kzd	173	33	is	be	VBZ
cord-294366-swwz4kzd	173	34	sterically	sterically	RB
cord-294366-swwz4kzd	173	35	restricted	restrict	VBN
cord-294366-swwz4kzd	173	36	on	on	IN
cord-294366-swwz4kzd	173	37	primary	primary	JJ
cord-294366-swwz4kzd	173	38	human	human	JJ
cord-294366-swwz4kzd	173	39	immunodeficiency	immunodeficiency	NN
cord-294366-swwz4kzd	173	40	virus	virus	NN
cord-294366-swwz4kzd	173	41	type	type	NN
cord-294366-swwz4kzd	173	42	1	1	CD
cord-294366-swwz4kzd	173	43	Public	public	JJ
cord-294366-swwz4kzd	173	44	health	health	NN
cord-294366-swwz4kzd	173	45	.	.	.
cord-294366-swwz4kzd	174	1	High	high	JJ
cord-294366-swwz4kzd	174	2	hopes	hope	NNS
cord-294366-swwz4kzd	174	3	and	and	CC
cord-294366-swwz4kzd	174	4	dilemmas	dilemma	NNS
cord-294366-swwz4kzd	174	5	for	for	IN
cord-294366-swwz4kzd	174	6	a	a	DT
cord-294366-swwz4kzd	174	7	cervical	cervical	JJ
cord-294366-swwz4kzd	174	8	cancer	cancer	NN
cord-294366-swwz4kzd	174	9	vaccine	vaccine	NN
cord-294366-swwz4kzd	174	10	Expression	expression	NN
cord-294366-swwz4kzd	174	11	of	of	IN
cord-294366-swwz4kzd	174	12	human	human	JJ
cord-294366-swwz4kzd	174	13	papillomavirus	papillomavirus	NN
cord-294366-swwz4kzd	174	14	type	type	NN
cord-294366-swwz4kzd	174	15	11	11	CD
cord-294366-swwz4kzd	174	16	L1	L1	NNP
cord-294366-swwz4kzd	174	17	protein	protein	NN
cord-294366-swwz4kzd	174	18	in	in	IN
cord-294366-swwz4kzd	174	19	insect	insect	NN
cord-294366-swwz4kzd	174	20	cells	cell	NNS
cord-294366-swwz4kzd	174	21	:	:	:
cord-294366-swwz4kzd	174	22	in	in	IN
cord-294366-swwz4kzd	174	23	vivo	vivo	NN
cord-294366-swwz4kzd	174	24	and	and	CC
cord-294366-swwz4kzd	174	25	in	in	IN
cord-294366-swwz4kzd	174	26	vitro	vitro	FW
cord-294366-swwz4kzd	174	27	assembly	assembly	NNP
cord-294366-swwz4kzd	174	28	of	of	IN
cord-294366-swwz4kzd	174	29	viruslike	viruslike	NNP
cord-294366-swwz4kzd	174	30	particles	particle	VBZ
cord-294366-swwz4kzd	174	31	Expression	expression	NN
cord-294366-swwz4kzd	174	32	of	of	IN
cord-294366-swwz4kzd	174	33	vaccinia	vaccinia	NN
cord-294366-swwz4kzd	174	34	recombinant	recombinant	JJ
cord-294366-swwz4kzd	174	35	HPV	HPV	NNP
cord-294366-swwz4kzd	174	36	16	16	CD
cord-294366-swwz4kzd	174	37	L1	L1	NNP
cord-294366-swwz4kzd	174	38	and	and	CC
cord-294366-swwz4kzd	174	39	L2	L2	NNP
cord-294366-swwz4kzd	174	40	ORF	ORF	NNP
cord-294366-swwz4kzd	174	41	proteins	protein	NNS
cord-294366-swwz4kzd	174	42	in	in	IN
cord-294366-swwz4kzd	174	43	epithelial	epithelial	JJ
cord-294366-swwz4kzd	174	44	cells	cell	NNS
cord-294366-swwz4kzd	174	45	is	be	VBZ
cord-294366-swwz4kzd	174	46	sufficient	sufficient	JJ
cord-294366-swwz4kzd	174	47	for	for	IN
cord-294366-swwz4kzd	174	48	assembly	assembly	NN
cord-294366-swwz4kzd	174	49	of	of	IN
cord-294366-swwz4kzd	174	50	HPV	HPV	NNP
cord-294366-swwz4kzd	174	51	virion	virion	NN
cord-294366-swwz4kzd	175	1	-like	-like	:
cord-294366-swwz4kzd	175	2	particles	particle	NNS
cord-294366-swwz4kzd	175	3	Development	Development	NNP
cord-294366-swwz4kzd	175	4	of	of	IN
cord-294366-swwz4kzd	175	5	vaccines	vaccine	NNS
cord-294366-swwz4kzd	175	6	against	against	IN
cord-294366-swwz4kzd	175	7	meningococcal	meningococcal	JJ
cord-294366-swwz4kzd	175	8	disease	disease	NN
cord-294366-swwz4kzd	175	9	Identification	identification	NN
cord-294366-swwz4kzd	175	10	of	of	IN
cord-294366-swwz4kzd	175	11	vaccine	vaccine	NN
cord-294366-swwz4kzd	175	12	candidates	candidate	NNS
cord-294366-swwz4kzd	175	13	against	against	IN
cord-294366-swwz4kzd	175	14	serogroup	serogroup	NNP
cord-294366-swwz4kzd	175	15	B	B	NNP
cord-294366-swwz4kzd	175	16	meningococcus	meningococcus	NN
cord-294366-swwz4kzd	175	17	by	by	IN
cord-294366-swwz4kzd	175	18	whole	whole	JJ
cord-294366-swwz4kzd	175	19	-	-	HYPH
cord-294366-swwz4kzd	175	20	genome	genome	NN
cord-294366-swwz4kzd	175	21	sequencing	sequencing	NN
cord-294366-swwz4kzd	175	22	Rapid	rapid	JJ
cord-294366-swwz4kzd	175	23	evolution	evolution	NN
cord-294366-swwz4kzd	175	24	of	of	IN
cord-294366-swwz4kzd	175	25	a	a	DT
cord-294366-swwz4kzd	175	26	protein	protein	NN
cord-294366-swwz4kzd	175	27	in	in	IN
cord-294366-swwz4kzd	175	28	vitro	vitro	FW
cord-294366-swwz4kzd	175	29	by	by	IN
cord-294366-swwz4kzd	175	30	DNA	dna	NN
cord-294366-swwz4kzd	175	31	shuffling	shuffle	VBG
cord-294366-swwz4kzd	175	32	Improved	improve	VBN
cord-294366-swwz4kzd	175	33	green	green	JJ
cord-294366-swwz4kzd	175	34	fluorescent	fluorescent	NN
cord-294366-swwz4kzd	175	35	protein	protein	NN
cord-294366-swwz4kzd	175	36	by	by	IN
cord-294366-swwz4kzd	175	37	molecular	molecular	JJ
cord-294366-swwz4kzd	175	38	evolution	evolution	NN
cord-294366-swwz4kzd	175	39	using	use	VBG
cord-294366-swwz4kzd	175	40	DNA	dna	NN
cord-294366-swwz4kzd	175	41	shuffling	shuffle	VBG
cord-294366-swwz4kzd	175	42	Evolution	evolution	NN
cord-294366-swwz4kzd	175	43	of	of	IN
cord-294366-swwz4kzd	175	44	a	a	DT
cord-294366-swwz4kzd	175	45	cytokine	cytokine	NN
cord-294366-swwz4kzd	175	46	using	use	VBG
cord-294366-swwz4kzd	175	47	DNA	dna	NN
cord-294366-swwz4kzd	175	48	family	family	NN
cord-294366-swwz4kzd	175	49	shuffling	shuffle	VBG
cord-294366-swwz4kzd	175	50	Directed	direct	VBN
cord-294366-swwz4kzd	175	51	evolution	evolution	NN
cord-294366-swwz4kzd	175	52	:	:	:
cord-294366-swwz4kzd	175	53	the	the	DT
cord-294366-swwz4kzd	175	54	'	'	``
cord-294366-swwz4kzd	175	55	rational	rational	JJ
cord-294366-swwz4kzd	175	56	'	'	''
cord-294366-swwz4kzd	175	57	basis	basis	NN
cord-294366-swwz4kzd	175	58	for	for	IN
cord-294366-swwz4kzd	175	59	'	'	``
cord-294366-swwz4kzd	175	60	irrational	irrational	JJ
cord-294366-swwz4kzd	175	61	'	'	''
cord-294366-swwz4kzd	175	62	design	design	NN
cord-294366-swwz4kzd	175	63	Molecular	molecular	JJ
cord-294366-swwz4kzd	175	64	breeding	breeding	NN
cord-294366-swwz4kzd	175	65	of	of	IN
cord-294366-swwz4kzd	175	66	allergy	allergy	NN
cord-294366-swwz4kzd	175	67	vaccines	vaccine	NNS
cord-294366-swwz4kzd	175	68	and	and	CC
cord-294366-swwz4kzd	175	69	antiallergic	antiallergic	NNP
cord-294366-swwz4kzd	175	70	cytokines	cytokine	NNS
cord-294366-swwz4kzd	176	1	A	a	DT
cord-294366-swwz4kzd	176	2	roadmap	roadmap	NN
cord-294366-swwz4kzd	176	3	for	for	IN
cord-294366-swwz4kzd	176	4	the	the	DT
cord-294366-swwz4kzd	176	5	immunomics	immunomic	NNS
cord-294366-swwz4kzd	176	6	of	of	IN
cord-294366-swwz4kzd	176	7	category	category	NN
cord-294366-swwz4kzd	176	8	A	A	NNP
cord-294366-swwz4kzd	176	9	-	-	HYPH
cord-294366-swwz4kzd	176	10	C	c	NN
cord-294366-swwz4kzd	176	11	pathogens	pathogen	NNS
cord-294366-swwz4kzd	176	12	Gene	gene	NN
cord-294366-swwz4kzd	176	13	-	-	HYPH
cord-294366-swwz4kzd	176	14	inducing	induce	VBG
cord-294366-swwz4kzd	176	15	program	program	NN
cord-294366-swwz4kzd	176	16	of	of	IN
cord-294366-swwz4kzd	176	17	human	human	JJ
cord-294366-swwz4kzd	176	18	dendritic	dendritic	JJ
cord-294366-swwz4kzd	176	19	cells	cell	NNS
cord-294366-swwz4kzd	176	20	in	in	IN
cord-294366-swwz4kzd	176	21	response	response	NN
cord-294366-swwz4kzd	176	22	to	to	IN
cord-294366-swwz4kzd	176	23	BCG	BCG	NNP
cord-294366-swwz4kzd	176	24	cellwall	cellwall	NNP
cord-294366-swwz4kzd	176	25	skeleton	skeleton	NN
cord-294366-swwz4kzd	176	26	(	(	-LRB-
cord-294366-swwz4kzd	176	27	CWS	CWS	NNP
cord-294366-swwz4kzd	176	28	)	)	-RRB-
cord-294366-swwz4kzd	176	29	,	,	,
cord-294366-swwz4kzd	176	30	which	which	WDT
cord-294366-swwz4kzd	176	31	reflects	reflect	VBZ
cord-294366-swwz4kzd	176	32	adjuvancy	adjuvancy	NNP
cord-294366-swwz4kzd	176	33	required	require	VBD
cord-294366-swwz4kzd	176	34	for	for	IN
cord-294366-swwz4kzd	176	35	tumor	tumor	NN
cord-294366-swwz4kzd	176	36	immunotherapy	immunotherapy	NN
cord-294366-swwz4kzd	177	1	The	the	DT
cord-294366-swwz4kzd	177	2	authors	author	NNS
cord-294366-swwz4kzd	177	3	thank	thank	VBP
cord-294366-swwz4kzd	177	4	Graham	Graham	NNP
cord-294366-swwz4kzd	177	5	Smith	Smith	NNP
cord-294366-swwz4kzd	177	6	at	at	IN
cord-294366-swwz4kzd	177	7	Aston	Aston	NNP
cord-294366-swwz4kzd	177	8	University	University	NNP
cord-294366-swwz4kzd	177	9	,	,	,
cord-294366-swwz4kzd	177	10	Birmingham	Birmingham	NNP
cord-294366-swwz4kzd	177	11	B4	B4	NNP
cord-294366-swwz4kzd	177	12	7ET	7ET	NNP
cord-294366-swwz4kzd	177	13	,	,	,
cord-294366-swwz4kzd	177	14	for	for	IN
cord-294366-swwz4kzd	177	15	his	-PRON-	PRP$
cord-294366-swwz4kzd	177	16	rendering	rendering	NN
cord-294366-swwz4kzd	177	17	of	of	IN
cord-294366-swwz4kzd	177	18	Figure	figure	NN
cord-294366-swwz4kzd	177	19	3	3	CD
cord-294366-swwz4kzd	177	20	.	.	.