id	sid	tid	token	lemma	pos
cord-284409-xiyeceib	1	1	key	key	NN
cord-284409-xiyeceib	1	2	:	:	:
cord-284409-xiyeceib	2	1	cord-284409-xiyeceib	cord-284409-xiyeceib	NNP
cord-284409-xiyeceib	3	1	authors	author	NNS
cord-284409-xiyeceib	3	2	:	:	:
cord-284409-xiyeceib	3	3	Prabakaran	Prabakaran	NNP
cord-284409-xiyeceib	3	4	,	,	,
cord-284409-xiyeceib	3	5	Ponraj	Ponraj	NNP
cord-284409-xiyeceib	3	6	;	;	:
cord-284409-xiyeceib	3	7	Chen	Chen	NNP
cord-284409-xiyeceib	3	8	,	,	,
cord-284409-xiyeceib	3	9	Weizao	Weizao	NNP
cord-284409-xiyeceib	3	10	;	;	:
cord-284409-xiyeceib	3	11	Dimitrov	Dimitrov	NNP
cord-284409-xiyeceib	3	12	,	,	,
cord-284409-xiyeceib	3	13	Dimiter	Dimiter	NNP
cord-284409-xiyeceib	3	14	S.	S.	NNP
cord-284409-xiyeceib	3	15	title	title	NN
cord-284409-xiyeceib	3	16	:	:	:
cord-284409-xiyeceib	3	17	The	the	DT
cord-284409-xiyeceib	3	18	Antibody	Antibody	NNP
cord-284409-xiyeceib	3	19	Germline	Germline	NNP
cord-284409-xiyeceib	3	20	/	/	SYM
cord-284409-xiyeceib	3	21	Maturation	Maturation	NNP
cord-284409-xiyeceib	3	22	Hypothesis	Hypothesis	NNP
cord-284409-xiyeceib	3	23	,	,	,
cord-284409-xiyeceib	3	24	Elicitation	Elicitation	NNP
cord-284409-xiyeceib	3	25	of	of	IN
cord-284409-xiyeceib	3	26	Broadly	broadly	RB
cord-284409-xiyeceib	3	27	Neutralizing	neutralize	VBG
cord-284409-xiyeceib	3	28	Antibodies	Antibodies	NNPS
cord-284409-xiyeceib	3	29	Against	against	IN
cord-284409-xiyeceib	3	30	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	3	31	and	and	CC
cord-284409-xiyeceib	3	32	Cord	Cord	NNP
cord-284409-xiyeceib	3	33	Blood	Blood	NNP
cord-284409-xiyeceib	3	34	IgM	igm	NN
cord-284409-xiyeceib	3	35	Repertoires	repertoire	NNS
cord-284409-xiyeceib	3	36	date	date	NN
cord-284409-xiyeceib	3	37	:	:	:
cord-284409-xiyeceib	3	38	2014	2014	CD
cord-284409-xiyeceib	3	39	-	-	HYPH
cord-284409-xiyeceib	3	40	08	08	CD
cord-284409-xiyeceib	3	41	-	-	HYPH
cord-284409-xiyeceib	3	42	28	28	CD
cord-284409-xiyeceib	3	43	journal	journal	NN
cord-284409-xiyeceib	3	44	:	:	:
cord-284409-xiyeceib	4	1	Front	Front	NNP
cord-284409-xiyeceib	4	2	Immunol	Immunol	NNP
cord-284409-xiyeceib	4	3	DOI	doi	NN
cord-284409-xiyeceib	4	4	:	:	:
cord-284409-xiyeceib	5	1	10.3389	10.3389	CD
cord-284409-xiyeceib	6	1	/fimmu.2014.00398	/fimmu.2014.00398	.
cord-284409-xiyeceib	7	1	sha	sha	NNP
cord-284409-xiyeceib	7	2	:	:	:
cord-284409-xiyeceib	7	3	a62bab2887ddd15979d7ef71e48ea7ae3596adf6	a62bab2887ddd15979d7ef71e48ea7ae3596adf6	NNP
cord-284409-xiyeceib	7	4	doc_id	doc_id	CD
cord-284409-xiyeceib	7	5	:	:	:
cord-284409-xiyeceib	7	6	284409	284409	CD
cord-284409-xiyeceib	7	7	cord_uid	cord_uid	NNS
cord-284409-xiyeceib	7	8	:	:	:
cord-284409-xiyeceib	8	1	xiyeceib	xiyeceib	NNP
cord-284409-xiyeceib	9	1	We	-PRON-	PRP
cord-284409-xiyeceib	9	2	have	have	VBP
cord-284409-xiyeceib	9	3	previously	previously	RB
cord-284409-xiyeceib	9	4	observed	observe	VBN
cord-284409-xiyeceib	9	5	that	that	IN
cord-284409-xiyeceib	9	6	all	all	DT
cord-284409-xiyeceib	9	7	known	know	VBN
cord-284409-xiyeceib	9	8	potent	potent	JJ
cord-284409-xiyeceib	9	9	broadly	broadly	RB
cord-284409-xiyeceib	9	10	neutralizing	neutralize	VBG
cord-284409-xiyeceib	9	11	antibodies	antibody	NNS
cord-284409-xiyeceib	9	12	(	(	-LRB-
cord-284409-xiyeceib	9	13	bnAbs	bnabs	NN
cord-284409-xiyeceib	9	14	)	)	-RRB-
cord-284409-xiyeceib	9	15	against	against	IN
cord-284409-xiyeceib	9	16	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	9	17	are	be	VBP
cord-284409-xiyeceib	9	18	highly	highly	RB
cord-284409-xiyeceib	9	19	divergent	divergent	JJ
cord-284409-xiyeceib	9	20	from	from	IN
cord-284409-xiyeceib	9	21	their	-PRON-	PRP$
cord-284409-xiyeceib	9	22	putative	putative	JJ
cord-284409-xiyeceib	9	23	germline	germline	JJ
cord-284409-xiyeceib	9	24	predecessors	predecessor	NNS
cord-284409-xiyeceib	9	25	in	in	IN
cord-284409-xiyeceib	9	26	contrast	contrast	NN
cord-284409-xiyeceib	9	27	to	to	IN
cord-284409-xiyeceib	9	28	bnAbs	bnabs	NN
cord-284409-xiyeceib	9	29	against	against	IN
cord-284409-xiyeceib	9	30	viruses	virus	NNS
cord-284409-xiyeceib	9	31	causing	cause	VBG
cord-284409-xiyeceib	9	32	acute	acute	JJ
cord-284409-xiyeceib	9	33	infections	infection	NNS
cord-284409-xiyeceib	9	34	such	such	JJ
cord-284409-xiyeceib	9	35	as	as	IN
cord-284409-xiyeceib	9	36	henipaviruses	henipaviruses	NNPS
cord-284409-xiyeceib	9	37	and	and	CC
cord-284409-xiyeceib	9	38	SARS	SARS	NNP
cord-284409-xiyeceib	9	39	CoV	CoV	NNP
cord-284409-xiyeceib	9	40	,	,	,
cord-284409-xiyeceib	9	41	which	which	WDT
cord-284409-xiyeceib	9	42	are	be	VBP
cord-284409-xiyeceib	9	43	much	much	RB
cord-284409-xiyeceib	9	44	less	less	RBR
cord-284409-xiyeceib	9	45	divergent	divergent	JJ
cord-284409-xiyeceib	9	46	from	from	IN
cord-284409-xiyeceib	9	47	their	-PRON-	PRP$
cord-284409-xiyeceib	9	48	germline	germline	JJ
cord-284409-xiyeceib	9	49	counterparts	counterpart	NNS
cord-284409-xiyeceib	9	50	.	.	.
cord-284409-xiyeceib	10	1	Consequently	consequently	RB
cord-284409-xiyeceib	10	2	,	,	,
cord-284409-xiyeceib	10	3	we	-PRON-	PRP
cord-284409-xiyeceib	10	4	have	have	VBP
cord-284409-xiyeceib	10	5	hypothesized	hypothesize	VBN
cord-284409-xiyeceib	10	6	that	that	IN
cord-284409-xiyeceib	10	7	germline	germline	JJ
cord-284409-xiyeceib	10	8	antibodies	antibody	NNS
cord-284409-xiyeceib	10	9	may	may	MD
cord-284409-xiyeceib	10	10	not	not	RB
cord-284409-xiyeceib	10	11	bind	bind	VB
cord-284409-xiyeceib	10	12	to	to	IN
cord-284409-xiyeceib	10	13	the	the	DT
cord-284409-xiyeceib	10	14	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	10	15	envelope	envelope	NN
cord-284409-xiyeceib	10	16	glycoprotein	glycoprotein	NN
cord-284409-xiyeceib	10	17	(	(	-LRB-
cord-284409-xiyeceib	10	18	Env	Env	NNP
cord-284409-xiyeceib	10	19	)	)	-RRB-
cord-284409-xiyeceib	10	20	because	because	IN
cord-284409-xiyeceib	10	21	they	-PRON-	PRP
cord-284409-xiyeceib	10	22	are	be	VBP
cord-284409-xiyeceib	10	23	so	so	RB
cord-284409-xiyeceib	10	24	different	different	JJ
cord-284409-xiyeceib	10	25	compared	compare	VBN
cord-284409-xiyeceib	10	26	to	to	IN
cord-284409-xiyeceib	10	27	the	the	DT
cord-284409-xiyeceib	10	28	highly	highly	RB
cord-284409-xiyeceib	10	29	somatically	somatically	RB
cord-284409-xiyeceib	10	30	mutated	mutate	VBN
cord-284409-xiyeceib	10	31	HIV-1-specific	HIV-1-specific	NNP
cord-284409-xiyeceib	10	32	bnAbs	bnabs	NN
cord-284409-xiyeceib	10	33	.	.	.
cord-284409-xiyeceib	11	1	We	-PRON-	PRP
cord-284409-xiyeceib	11	2	have	have	VBP
cord-284409-xiyeceib	11	3	further	further	RB
cord-284409-xiyeceib	11	4	hypothesized	hypothesize	VBN
cord-284409-xiyeceib	11	5	that	that	IN
cord-284409-xiyeceib	11	6	the	the	DT
cord-284409-xiyeceib	11	7	immunogenicity	immunogenicity	NN
cord-284409-xiyeceib	11	8	of	of	IN
cord-284409-xiyeceib	11	9	highly	highly	RB
cord-284409-xiyeceib	11	10	conserved	conserve	VBN
cord-284409-xiyeceib	11	11	epitopes	epitope	NNS
cord-284409-xiyeceib	11	12	on	on	IN
cord-284409-xiyeceib	11	13	the	the	DT
cord-284409-xiyeceib	11	14	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	11	15	envelope	envelope	NN
cord-284409-xiyeceib	11	16	glycoproteins	glycoprotein	NNS
cord-284409-xiyeceib	11	17	(	(	-LRB-
cord-284409-xiyeceib	11	18	Envs	Envs	NNP
cord-284409-xiyeceib	11	19	)	)	-RRB-
cord-284409-xiyeceib	11	20	may	may	MD
cord-284409-xiyeceib	11	21	be	be	VB
cord-284409-xiyeceib	11	22	reduced	reduce	VBN
cord-284409-xiyeceib	11	23	or	or	CC
cord-284409-xiyeceib	11	24	eliminated	eliminate	VBN
cord-284409-xiyeceib	11	25	by	by	IN
cord-284409-xiyeceib	11	26	their	-PRON-	PRP$
cord-284409-xiyeceib	11	27	very	very	RB
cord-284409-xiyeceib	11	28	weak	weak	JJ
cord-284409-xiyeceib	11	29	or	or	CC
cord-284409-xiyeceib	11	30	absent	absent	JJ
cord-284409-xiyeceib	11	31	interactions	interaction	NNS
cord-284409-xiyeceib	11	32	with	with	IN
cord-284409-xiyeceib	11	33	germline	germline	JJ
cord-284409-xiyeceib	11	34	antibodies	antibody	NNS
cord-284409-xiyeceib	11	35	and	and	CC
cord-284409-xiyeceib	11	36	immune	immune	JJ
cord-284409-xiyeceib	11	37	responses	response	NNS
cord-284409-xiyeceib	11	38	leading	lead	VBG
cord-284409-xiyeceib	11	39	to	to	IN
cord-284409-xiyeceib	11	40	the	the	DT
cord-284409-xiyeceib	11	41	elicitation	elicitation	NN
cord-284409-xiyeceib	11	42	of	of	IN
cord-284409-xiyeceib	11	43	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	11	44	may	may	MD
cord-284409-xiyeceib	11	45	not	not	RB
cord-284409-xiyeceib	11	46	be	be	VB
cord-284409-xiyeceib	11	47	initiated	initiate	VBN
cord-284409-xiyeceib	11	48	and/or	and/or	CC
cord-284409-xiyeceib	11	49	sustained	sustained	JJ
cord-284409-xiyeceib	11	50	.	.	.
cord-284409-xiyeceib	12	1	Even	even	RB
cord-284409-xiyeceib	12	2	if	if	IN
cord-284409-xiyeceib	12	3	such	such	JJ
cord-284409-xiyeceib	12	4	responses	response	NNS
cord-284409-xiyeceib	12	5	are	be	VBP
cord-284409-xiyeceib	12	6	initiated	initiate	VBN
cord-284409-xiyeceib	12	7	,	,	,
cord-284409-xiyeceib	12	8	the	the	DT
cord-284409-xiyeceib	12	9	maturation	maturation	NN
cord-284409-xiyeceib	12	10	pathways	pathway	NNS
cord-284409-xiyeceib	12	11	are	be	VBP
cord-284409-xiyeceib	12	12	so	so	RB
cord-284409-xiyeceib	12	13	extraordinarily	extraordinarily	RB
cord-284409-xiyeceib	12	14	complex	complex	JJ
cord-284409-xiyeceib	12	15	that	that	IN
cord-284409-xiyeceib	12	16	prolonged	prolong	VBN
cord-284409-xiyeceib	12	17	periods	period	NNS
cord-284409-xiyeceib	12	18	of	of	IN
cord-284409-xiyeceib	12	19	time	time	NN
cord-284409-xiyeceib	12	20	may	may	MD
cord-284409-xiyeceib	12	21	be	be	VB
cord-284409-xiyeceib	12	22	required	require	VBN
cord-284409-xiyeceib	12	23	for	for	IN
cord-284409-xiyeceib	12	24	elicitation	elicitation	NN
cord-284409-xiyeceib	12	25	of	of	IN
cord-284409-xiyeceib	12	26	bnAbs	bnabs	NN
cord-284409-xiyeceib	12	27	with	with	IN
cord-284409-xiyeceib	12	28	defined	define	VBN
cord-284409-xiyeceib	12	29	unique	unique	JJ
cord-284409-xiyeceib	12	30	sequences	sequence	NNS
cord-284409-xiyeceib	12	31	.	.	.
cord-284409-xiyeceib	13	1	We	-PRON-	PRP
cord-284409-xiyeceib	13	2	provided	provide	VBD
cord-284409-xiyeceib	13	3	the	the	DT
cord-284409-xiyeceib	13	4	initial	initial	JJ
cord-284409-xiyeceib	13	5	evidence	evidence	NN
cord-284409-xiyeceib	13	6	supporting	support	VBG
cord-284409-xiyeceib	13	7	this	this	DT
cord-284409-xiyeceib	13	8	antibody	antibody	NN
cord-284409-xiyeceib	13	9	germline	germline	NN
cord-284409-xiyeceib	13	10	/	/	SYM
cord-284409-xiyeceib	13	11	maturation	maturation	NN
cord-284409-xiyeceib	13	12	hypothesis	hypothesis	NN
cord-284409-xiyeceib	13	13	,	,	,
cord-284409-xiyeceib	13	14	which	which	WDT
cord-284409-xiyeceib	13	15	prompted	prompt	VBD
cord-284409-xiyeceib	13	16	a	a	DT
cord-284409-xiyeceib	13	17	number	number	NN
cord-284409-xiyeceib	13	18	of	of	IN
cord-284409-xiyeceib	13	19	studies	study	NNS
cord-284409-xiyeceib	13	20	to	to	TO
cord-284409-xiyeceib	13	21	design	design	VB
cord-284409-xiyeceib	13	22	vaccine	vaccine	NN
cord-284409-xiyeceib	13	23	immunogens	immunogen	NNS
cord-284409-xiyeceib	13	24	that	that	WDT
cord-284409-xiyeceib	13	25	could	could	MD
cord-284409-xiyeceib	13	26	bind	bind	VB
cord-284409-xiyeceib	13	27	putative	putative	JJ
cord-284409-xiyeceib	13	28	germline	germline	JJ
cord-284409-xiyeceib	13	29	predecessors	predecessor	NNS
cord-284409-xiyeceib	13	30	of	of	IN
cord-284409-xiyeceib	13	31	known	know	VBN
cord-284409-xiyeceib	13	32	bnAbs	bnabs	NN
cord-284409-xiyeceib	13	33	and	and	CC
cord-284409-xiyeceib	13	34	to	to	TO
cord-284409-xiyeceib	13	35	explore	explore	VB
cord-284409-xiyeceib	13	36	complex	complex	JJ
cord-284409-xiyeceib	13	37	B	b	NN
cord-284409-xiyeceib	13	38	cell	cell	NN
cord-284409-xiyeceib	13	39	lineages	lineage	NNS
cord-284409-xiyeceib	13	40	.	.	.
cord-284409-xiyeceib	14	1	However	however	RB
cord-284409-xiyeceib	14	2	,	,	,
cord-284409-xiyeceib	14	3	guiding	guide	VBG
cord-284409-xiyeceib	14	4	the	the	DT
cord-284409-xiyeceib	14	5	immune	immune	JJ
cord-284409-xiyeceib	14	6	system	system	NN
cord-284409-xiyeceib	14	7	through	through	IN
cord-284409-xiyeceib	14	8	the	the	DT
cord-284409-xiyeceib	14	9	exceptionally	exceptionally	RB
cord-284409-xiyeceib	14	10	complex	complex	JJ
cord-284409-xiyeceib	14	11	antibody	antibody	NN
cord-284409-xiyeceib	14	12	maturation	maturation	NN
cord-284409-xiyeceib	14	13	pathways	pathway	NNS
cord-284409-xiyeceib	14	14	to	to	TO
cord-284409-xiyeceib	14	15	elicit	elicit	VB
cord-284409-xiyeceib	14	16	known	know	VBN
cord-284409-xiyeceib	14	17	bnAbs	bnabs	NN
cord-284409-xiyeceib	14	18	remains	remain	VBZ
cord-284409-xiyeceib	14	19	a	a	DT
cord-284409-xiyeceib	14	20	major	major	JJ
cord-284409-xiyeceib	14	21	challenge	challenge	NN
cord-284409-xiyeceib	14	22	.	.	.
cord-284409-xiyeceib	15	1	Here	here	RB
cord-284409-xiyeceib	15	2	,	,	,
cord-284409-xiyeceib	15	3	we	-PRON-	PRP
cord-284409-xiyeceib	15	4	discuss	discuss	VBP
cord-284409-xiyeceib	15	5	studies	study	NNS
cord-284409-xiyeceib	15	6	exploring	explore	VBG
cord-284409-xiyeceib	15	7	the	the	DT
cord-284409-xiyeceib	15	8	antibody	antibody	NN
cord-284409-xiyeceib	15	9	germline	germline	NN
cord-284409-xiyeceib	15	10	/	/	SYM
cord-284409-xiyeceib	15	11	maturation	maturation	NN
cord-284409-xiyeceib	15	12	hypothesis	hypothesis	NN
cord-284409-xiyeceib	15	13	as	as	IN
cord-284409-xiyeceib	15	14	related	relate	VBN
cord-284409-xiyeceib	15	15	to	to	IN
cord-284409-xiyeceib	15	16	elicitation	elicitation	NN
cord-284409-xiyeceib	15	17	of	of	IN
cord-284409-xiyeceib	15	18	bnAbs	bnabs	NN
cord-284409-xiyeceib	15	19	against	against	IN
cord-284409-xiyeceib	15	20	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	15	21	and	and	CC
cord-284409-xiyeceib	15	22	present	present	VB
cord-284409-xiyeceib	15	23	our	-PRON-	PRP$
cord-284409-xiyeceib	15	24	recent	recent	JJ
cord-284409-xiyeceib	15	25	data	datum	NNS
cord-284409-xiyeceib	15	26	demonstrating	demonstrate	VBG
cord-284409-xiyeceib	15	27	the	the	DT
cord-284409-xiyeceib	15	28	existence	existence	NN
cord-284409-xiyeceib	15	29	of	of	IN
cord-284409-xiyeceib	15	30	germline	germline	NN
cord-284409-xiyeceib	15	31	-	-	HYPH
cord-284409-xiyeceib	15	32	like	like	JJ
cord-284409-xiyeceib	15	33	precursors	precursor	NNS
cord-284409-xiyeceib	15	34	of	of	IN
cord-284409-xiyeceib	15	35	VRC01	VRC01	NNP
cord-284409-xiyeceib	15	36	antibodies	antibody	NNS
cord-284409-xiyeceib	15	37	in	in	IN
cord-284409-xiyeceib	15	38	a	a	DT
cord-284409-xiyeceib	15	39	human	human	JJ
cord-284409-xiyeceib	15	40	cord	cord	NN
cord-284409-xiyeceib	15	41	blood	blood	NN
cord-284409-xiyeceib	15	42	IgM	IgM	NNP
cord-284409-xiyeceib	15	43	library	library	NNP
cord-284409-xiyeceib	15	44	.	.	.
cord-284409-xiyeceib	16	1	Elicitation	Elicitation	NNP
cord-284409-xiyeceib	16	2	of	of	IN
cord-284409-xiyeceib	16	3	broadly	broadly	RB
cord-284409-xiyeceib	16	4	neutralizing	neutralize	VBG
cord-284409-xiyeceib	16	5	antibodies	antibody	NNS
cord-284409-xiyeceib	16	6	(	(	-LRB-
cord-284409-xiyeceib	16	7	bnAbs	bnabs	NN
cord-284409-xiyeceib	16	8	)	)	-RRB-
cord-284409-xiyeceib	16	9	targeting	target	VBG
cord-284409-xiyeceib	16	10	the	the	DT
cord-284409-xiyeceib	16	11	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	16	12	envelope	envelope	NN
cord-284409-xiyeceib	16	13	glycoproteins	glycoprotein	NNS
cord-284409-xiyeceib	16	14	(	(	-LRB-
cord-284409-xiyeceib	16	15	Envs	Envs	NNP
cord-284409-xiyeceib	16	16	)	)	-RRB-
cord-284409-xiyeceib	16	17	,	,	,
cord-284409-xiyeceib	16	18	the	the	DT
cord-284409-xiyeceib	16	19	key	key	NN
cord-284409-xiyeceib	16	20	to	to	IN
cord-284409-xiyeceib	16	21	an	an	DT
cord-284409-xiyeceib	16	22	effective	effective	JJ
cord-284409-xiyeceib	16	23	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	16	24	vaccine	vaccine	NN
cord-284409-xiyeceib	16	25	,	,	,
cord-284409-xiyeceib	16	26	remains	remain	VBZ
cord-284409-xiyeceib	16	27	elusive	elusive	JJ
cord-284409-xiyeceib	16	28	.	.	.
cord-284409-xiyeceib	17	1	Previous	previous	JJ
cord-284409-xiyeceib	17	2	studies	study	NNS
cord-284409-xiyeceib	17	3	have	have	VBP
cord-284409-xiyeceib	17	4	demonstrated	demonstrate	VBN
cord-284409-xiyeceib	17	5	several	several	JJ
cord-284409-xiyeceib	17	6	properties	property	NNS
cord-284409-xiyeceib	17	7	of	of	IN
cord-284409-xiyeceib	17	8	the	the	DT
cord-284409-xiyeceib	17	9	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	17	10	Envs	Envs	NNP
cord-284409-xiyeceib	17	11	that	that	WDT
cord-284409-xiyeceib	17	12	could	could	MD
cord-284409-xiyeceib	17	13	limit	limit	VB
cord-284409-xiyeceib	17	14	their	-PRON-	PRP$
cord-284409-xiyeceib	17	15	ability	ability	NN
cord-284409-xiyeceib	17	16	to	to	TO
cord-284409-xiyeceib	17	17	elicit	elicit	VB
cord-284409-xiyeceib	17	18	bnAbs	bnabs	NN
cord-284409-xiyeceib	17	19	.	.	.
cord-284409-xiyeceib	18	1	These	these	DT
cord-284409-xiyeceib	18	2	include	include	VBP
cord-284409-xiyeceib	18	3	protection	protection	NN
cord-284409-xiyeceib	18	4	of	of	IN
cord-284409-xiyeceib	18	5	the	the	DT
cord-284409-xiyeceib	18	6	conserved	conserve	VBN
cord-284409-xiyeceib	18	7	structures	structure	NNS
cord-284409-xiyeceib	18	8	by	by	IN
cord-284409-xiyeceib	18	9	variable	variable	JJ
cord-284409-xiyeceib	18	10	loops	loop	NNS
cord-284409-xiyeceib	18	11	(	(	-LRB-
cord-284409-xiyeceib	18	12	1	1	CD
cord-284409-xiyeceib	18	13	)	)	-RRB-
cord-284409-xiyeceib	18	14	(	(	-LRB-
cord-284409-xiyeceib	18	15	2	2	LS
cord-284409-xiyeceib	18	16	)	)	-RRB-
cord-284409-xiyeceib	18	17	(	(	-LRB-
cord-284409-xiyeceib	18	18	3	3	LS
cord-284409-xiyeceib	18	19	)	)	-RRB-
cord-284409-xiyeceib	18	20	,	,	,
cord-284409-xiyeceib	18	21	remarkable	remarkable	JJ
cord-284409-xiyeceib	18	22	genetic	genetic	JJ
cord-284409-xiyeceib	18	23	diversity	diversity	NN
cord-284409-xiyeceib	18	24	(	(	-LRB-
cord-284409-xiyeceib	18	25	4	4	CD
cord-284409-xiyeceib	18	26	)	)	-RRB-
cord-284409-xiyeceib	18	27	,	,	,
cord-284409-xiyeceib	18	28	a	a	DT
cord-284409-xiyeceib	18	29	glycan	glycan	NN
cord-284409-xiyeceib	18	30	shield	shield	NN
cord-284409-xiyeceib	18	31	(	(	-LRB-
cord-284409-xiyeceib	18	32	5	5	CD
cord-284409-xiyeceib	18	33	)	)	-RRB-
cord-284409-xiyeceib	18	34	,	,	,
cord-284409-xiyeceib	18	35	steric	steric	JJ
cord-284409-xiyeceib	18	36	occlusion	occlusion	NN
cord-284409-xiyeceib	18	37	(	(	-LRB-
cord-284409-xiyeceib	18	38	6	6	CD
cord-284409-xiyeceib	18	39	)	)	-RRB-
cord-284409-xiyeceib	18	40	,	,	,
cord-284409-xiyeceib	18	41	and	and	CC
cord-284409-xiyeceib	18	42	conformational	conformational	JJ
cord-284409-xiyeceib	18	43	masking	masking	NN
cord-284409-xiyeceib	18	44	(	(	-LRB-
cord-284409-xiyeceib	18	45	7	7	CD
cord-284409-xiyeceib	18	46	)	)	-RRB-
cord-284409-xiyeceib	18	47	.	.	.
cord-284409-xiyeceib	19	1	Until	until	IN
cord-284409-xiyeceib	19	2	6	6	CD
cord-284409-xiyeceib	19	3	years	year	NNS
cord-284409-xiyeceib	19	4	ago	ago	RB
cord-284409-xiyeceib	19	5	,	,	,
cord-284409-xiyeceib	19	6	only	only	RB
cord-284409-xiyeceib	19	7	a	a	DT
cord-284409-xiyeceib	19	8	handful	handful	NN
cord-284409-xiyeceib	19	9	of	of	IN
cord-284409-xiyeceib	19	10	bnAbs	bnabs	NN
cord-284409-xiyeceib	19	11	,	,	,
cord-284409-xiyeceib	19	12	including	include	VBG
cord-284409-xiyeceib	19	13	b12	b12	NN
cord-284409-xiyeceib	19	14	,	,	,
cord-284409-xiyeceib	19	15	2G12	2g12	CD
cord-284409-xiyeceib	19	16	,	,	,
cord-284409-xiyeceib	19	17	2F5	2f5	CD
cord-284409-xiyeceib	19	18	,	,	,
cord-284409-xiyeceib	19	19	and	and	CC
cord-284409-xiyeceib	19	20	4E10	4e10	CD
cord-284409-xiyeceib	19	21	,	,	,
cord-284409-xiyeceib	19	22	were	be	VBD
cord-284409-xiyeceib	19	23	known	know	VBN
cord-284409-xiyeceib	19	24	.	.	.
cord-284409-xiyeceib	20	1	Although	although	IN
cord-284409-xiyeceib	20	2	the	the	DT
cord-284409-xiyeceib	20	3	structural	structural	JJ
cord-284409-xiyeceib	20	4	and	and	CC
cord-284409-xiyeceib	20	5	functional	functional	JJ
cord-284409-xiyeceib	20	6	studies	study	NNS
cord-284409-xiyeceib	20	7	of	of	IN
cord-284409-xiyeceib	20	8	those	those	DT
cord-284409-xiyeceib	20	9	bnAbs	bnabs	NN
cord-284409-xiyeceib	20	10	revealed	reveal	VBD
cord-284409-xiyeceib	20	11	some	some	DT
cord-284409-xiyeceib	20	12	important	important	JJ
cord-284409-xiyeceib	20	13	neutralization	neutralization	NN
cord-284409-xiyeceib	20	14	epitopes	epitope	NNS
cord-284409-xiyeceib	20	15	(	(	-LRB-
cord-284409-xiyeceib	20	16	8)	8)	NNP
cord-284409-xiyeceib	20	17	,	,	,
cord-284409-xiyeceib	20	18	such	such	JJ
cord-284409-xiyeceib	20	19	bnAbs	bnabs	NN
cord-284409-xiyeceib	20	20	have	have	VBP
cord-284409-xiyeceib	20	21	not	not	RB
cord-284409-xiyeceib	20	22	been	be	VBN
cord-284409-xiyeceib	20	23	successfully	successfully	RB
cord-284409-xiyeceib	20	24	elicited	elicit	VBN
cord-284409-xiyeceib	20	25	by	by	IN
cord-284409-xiyeceib	20	26	any	any	DT
cord-284409-xiyeceib	20	27	vaccination	vaccination	NN
cord-284409-xiyeceib	20	28	approach	approach	NN
cord-284409-xiyeceib	20	29	.	.	.
cord-284409-xiyeceib	21	1	In	in	IN
cord-284409-xiyeceib	21	2	2007	2007	CD
cord-284409-xiyeceib	21	3	,	,	,
cord-284409-xiyeceib	21	4	we	-PRON-	PRP
cord-284409-xiyeceib	21	5	first	first	RB
cord-284409-xiyeceib	21	6	noted	note	VBD
cord-284409-xiyeceib	21	7	that	that	IN
cord-284409-xiyeceib	21	8	in	in	IN
cord-284409-xiyeceib	21	9	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	21	10	specific	specific	JJ
cord-284409-xiyeceib	21	11	bnAbs	bnabs	NN
cord-284409-xiyeceib	21	12	the	the	DT
cord-284409-xiyeceib	21	13	number	number	NN
cord-284409-xiyeceib	21	14	of	of	IN
cord-284409-xiyeceib	21	15	amino	amino	NN
cord-284409-xiyeceib	21	16	acid	acid	NN
cord-284409-xiyeceib	21	17	mutations	mutation	NNS
cord-284409-xiyeceib	21	18	from	from	IN
cord-284409-xiyeceib	21	19	their	-PRON-	PRP$
cord-284409-xiyeceib	21	20	closest	close	JJS
cord-284409-xiyeceib	21	21	corresponding	corresponding	JJ
cord-284409-xiyeceib	21	22	germline	germline	NN
cord-284409-xiyeceib	21	23	sequences	sequence	NNS
cord-284409-xiyeceib	21	24	was	be	VBD
cord-284409-xiyeceib	21	25	significantly	significantly	RB
cord-284409-xiyeceib	21	26	higher	high	JJR
cord-284409-xiyeceib	21	27	than	than	IN
cord-284409-xiyeceib	21	28	that	that	DT
cord-284409-xiyeceib	21	29	of	of	IN
cord-284409-xiyeceib	21	30	bnAbs	bnabs	NN
cord-284409-xiyeceib	21	31	against	against	IN
cord-284409-xiyeceib	21	32	the	the	DT
cord-284409-xiyeceib	21	33	SARS	SARS	NNP
cord-284409-xiyeceib	21	34	CoV	cov	NN
cord-284409-xiyeceib	21	35	coronavirus	coronavirus	NNP
cord-284409-xiyeceib	21	36	,	,	,
cord-284409-xiyeceib	21	37	and	and	CC
cord-284409-xiyeceib	21	38	Hendra	Hendra	NNP
cord-284409-xiyeceib	21	39	and	and	CC
cord-284409-xiyeceib	21	40	Nipah	Nipah	NNP
cord-284409-xiyeceib	21	41	viruses	virus	NNS
cord-284409-xiyeceib	21	42	,	,	,
cord-284409-xiyeceib	21	43	which	which	WDT
cord-284409-xiyeceib	21	44	cause	cause	VBP
cord-284409-xiyeceib	21	45	self	self	NN
cord-284409-xiyeceib	21	46	-	-	HYPH
cord-284409-xiyeceib	21	47	limiting	limit	VBG
cord-284409-xiyeceib	21	48	acute	acute	JJ
cord-284409-xiyeceib	21	49	infections	infection	NNS
cord-284409-xiyeceib	21	50	(	(	-LRB-
cord-284409-xiyeceib	21	51	9	9	CD
cord-284409-xiyeceib	21	52	)	)	-RRB-
cord-284409-xiyeceib	21	53	.	.	.
cord-284409-xiyeceib	22	1	Using	use	VBG
cord-284409-xiyeceib	22	2	a	a	DT
cord-284409-xiyeceib	22	3	large	large	JJ
cord-284409-xiyeceib	22	4	nonimmune	nonimmune	NNP
cord-284409-xiyeceib	22	5	IgM	IgM	NNP
cord-284409-xiyeceib	22	6	library	library	NNP
cord-284409-xiyeceib	22	7	,	,	,
cord-284409-xiyeceib	22	8	we	-PRON-	PRP
cord-284409-xiyeceib	22	9	identified	identify	VBD
cord-284409-xiyeceib	22	10	several	several	JJ
cord-284409-xiyeceib	22	11	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	22	12	Env	Env	NNP
cord-284409-xiyeceib	22	13	specific	specific	JJ
cord-284409-xiyeceib	22	14	antibodies	antibody	NNS
cord-284409-xiyeceib	22	15	and	and	CC
cord-284409-xiyeceib	22	16	found	find	VBD
cord-284409-xiyeceib	22	17	that	that	IN
cord-284409-xiyeceib	22	18	they	-PRON-	PRP
cord-284409-xiyeceib	22	19	had	have	VBD
cord-284409-xiyeceib	22	20	fewer	few	JJR
cord-284409-xiyeceib	22	21	somatic	somatic	JJ
cord-284409-xiyeceib	22	22	mutations	mutation	NNS
cord-284409-xiyeceib	22	23	than	than	IN
cord-284409-xiyeceib	22	24	the	the	DT
cord-284409-xiyeceib	22	25	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	22	26	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	22	27	,	,	,
cord-284409-xiyeceib	22	28	as	as	RB
cord-284409-xiyeceib	22	29	well	well	RB
cord-284409-xiyeceib	22	30	as	as	IN
cord-284409-xiyeceib	22	31	limited	limit	VBN
cord-284409-xiyeceib	22	32	neutralizing	neutralize	VBG
cord-284409-xiyeceib	22	33	activity	activity	NN
cord-284409-xiyeceib	22	34	(	(	-LRB-
cord-284409-xiyeceib	22	35	9	9	CD
cord-284409-xiyeceib	22	36	)	)	-RRB-
cord-284409-xiyeceib	22	37	.	.	.
cord-284409-xiyeceib	23	1	These	these	DT
cord-284409-xiyeceib	23	2	findings	finding	NNS
cord-284409-xiyeceib	23	3	indicated	indicate	VBD
cord-284409-xiyeceib	23	4	that	that	IN
cord-284409-xiyeceib	23	5	elicitation	elicitation	NN
cord-284409-xiyeceib	23	6	of	of	IN
cord-284409-xiyeceib	23	7	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	23	8	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	23	9	would	would	MD
cord-284409-xiyeceib	23	10	require	require	VB
cord-284409-xiyeceib	23	11	far	far	RB
cord-284409-xiyeceib	23	12	more	more	RBR
cord-284409-xiyeceib	23	13	extensive	extensive	JJ
cord-284409-xiyeceib	23	14	maturation	maturation	NN
cord-284409-xiyeceib	23	15	processes	process	NNS
cord-284409-xiyeceib	23	16	than	than	IN
cord-284409-xiyeceib	23	17	those	those	DT
cord-284409-xiyeceib	23	18	needed	need	VBN
cord-284409-xiyeceib	23	19	to	to	TO
cord-284409-xiyeceib	23	20	generate	generate	VB
cord-284409-xiyeceib	23	21	the	the	DT
cord-284409-xiyeceib	23	22	bnAbs	bnabs	NN
cord-284409-xiyeceib	23	23	against	against	IN
cord-284409-xiyeceib	23	24	the	the	DT
cord-284409-xiyeceib	23	25	SARS	SARS	NNP
cord-284409-xiyeceib	23	26	CoV	CoV	NNP
cord-284409-xiyeceib	23	27	and	and	CC
cord-284409-xiyeceib	23	28	henipaviruses	henipaviruse	NNS
cord-284409-xiyeceib	23	29	.	.	.
cord-284409-xiyeceib	24	1	So	so	RB
cord-284409-xiyeceib	24	2	,	,	,
cord-284409-xiyeceib	24	3	we	-PRON-	PRP
cord-284409-xiyeceib	24	4	have	have	VBP
cord-284409-xiyeceib	24	5	suggested	suggest	VBN
cord-284409-xiyeceib	24	6	that	that	IN
cord-284409-xiyeceib	24	7	the	the	DT
cord-284409-xiyeceib	24	8	difficulty	difficulty	NN
cord-284409-xiyeceib	24	9	of	of	IN
cord-284409-xiyeceib	24	10	eliciting	elicit	VBG
cord-284409-xiyeceib	24	11	these	these	DT
cord-284409-xiyeceib	24	12	bnAbs	bnabs	NN
cord-284409-xiyeceib	24	13	may	may	MD
cord-284409-xiyeceib	24	14	be	be	VB
cord-284409-xiyeceib	24	15	due	due	JJ
cord-284409-xiyeceib	24	16	,	,	,
cord-284409-xiyeceib	24	17	at	at	IN
cord-284409-xiyeceib	24	18	least	least	JJS
cord-284409-xiyeceib	24	19	in	in	IN
cord-284409-xiyeceib	24	20	part	part	NN
cord-284409-xiyeceib	24	21	,	,	,
cord-284409-xiyeceib	24	22	to	to	IN
cord-284409-xiyeceib	24	23	the	the	DT
cord-284409-xiyeceib	24	24	complex	complex	JJ
cord-284409-xiyeceib	24	25	and	and	CC
cord-284409-xiyeceib	24	26	prolonged	prolonged	JJ
cord-284409-xiyeceib	24	27	maturation	maturation	NN
cord-284409-xiyeceib	24	28	pathways	pathway	NNS
cord-284409-xiyeceib	24	29	required	require	VBN
cord-284409-xiyeceib	24	30	for	for	IN
cord-284409-xiyeceib	24	31	the	the	DT
cord-284409-xiyeceib	24	32	development	development	NN
cord-284409-xiyeceib	24	33	of	of	IN
cord-284409-xiyeceib	24	34	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	24	35	against	against	IN
cord-284409-xiyeceib	24	36	the	the	DT
cord-284409-xiyeceib	24	37	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	24	38	,	,	,
cord-284409-xiyeceib	24	39	which	which	WDT
cord-284409-xiyeceib	24	40	can	can	MD
cord-284409-xiyeceib	24	41	take	take	VB
cord-284409-xiyeceib	24	42	long	long	JJ
cord-284409-xiyeceib	24	43	time	time	NN
cord-284409-xiyeceib	24	44	(	(	-LRB-
cord-284409-xiyeceib	24	45	10	10	CD
cord-284409-xiyeceib	24	46	)	)	-RRB-
cord-284409-xiyeceib	24	47	.	.	.
cord-284409-xiyeceib	25	1	We	-PRON-	PRP
cord-284409-xiyeceib	25	2	thus	thus	RB
cord-284409-xiyeceib	25	3	speculated	speculate	VBD
cord-284409-xiyeceib	25	4	that	that	IN
cord-284409-xiyeceib	25	5	this	this	DT
cord-284409-xiyeceib	25	6	may	may	MD
cord-284409-xiyeceib	25	7	represent	represent	VB
cord-284409-xiyeceib	25	8	another	another	DT
cord-284409-xiyeceib	25	9	significant	significant	JJ
cord-284409-xiyeceib	25	10	challenge	challenge	NN
cord-284409-xiyeceib	25	11	in	in	IN
cord-284409-xiyeceib	25	12	the	the	DT
cord-284409-xiyeceib	25	13	development	development	NN
cord-284409-xiyeceib	25	14	of	of	IN
cord-284409-xiyeceib	25	15	effective	effective	JJ
cord-284409-xiyeceib	25	16	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	25	17	vaccines	vaccine	NNS
cord-284409-xiyeceib	25	18	.	.	.
cord-284409-xiyeceib	26	1	We	-PRON-	PRP
cord-284409-xiyeceib	26	2	quantified	quantify	VBD
cord-284409-xiyeceib	26	3	the	the	DT
cord-284409-xiyeceib	26	4	number	number	NN
cord-284409-xiyeceib	26	5	of	of	IN
cord-284409-xiyeceib	26	6	mutations	mutation	NNS
cord-284409-xiyeceib	26	7	in	in	IN
cord-284409-xiyeceib	26	8	human	human	JJ
cord-284409-xiyeceib	26	9	monoclonal	monoclonal	JJ
cord-284409-xiyeceib	26	10	antibodies	antibody	NNS
cord-284409-xiyeceib	26	11	(	(	-LRB-
cord-284409-xiyeceib	26	12	mAbs	mAbs	NNP
cord-284409-xiyeceib	26	13	)	)	-RRB-
cord-284409-xiyeceib	26	14	that	that	IN
cord-284409-xiyeceib	26	15	we	-PRON-	PRP
cord-284409-xiyeceib	26	16	selected	select	VBD
cord-284409-xiyeceib	26	17	from	from	IN
cord-284409-xiyeceib	26	18	phage	phage	NN
cord-284409-xiyeceib	26	19	libraries	library	NNS
cord-284409-xiyeceib	26	20	generated	generate	VBN
cord-284409-xiyeceib	26	21	from	from	IN
cord-284409-xiyeceib	26	22	an	an	DT
cord-284409-xiyeceib	26	23	HIV-1-infected	hiv-1-infecte	VBN
cord-284409-xiyeceib	26	24	patient	patient	NN
cord-284409-xiyeceib	26	25	with	with	IN
cord-284409-xiyeceib	26	26	a	a	DT
cord-284409-xiyeceib	26	27	known	know	VBN
cord-284409-xiyeceib	26	28	time	time	NN
cord-284409-xiyeceib	26	29	of	of	IN
cord-284409-xiyeceib	26	30	infection	infection	NN
cord-284409-xiyeceib	26	31	(	(	-LRB-
cord-284409-xiyeceib	26	32	10	10	CD
cord-284409-xiyeceib	26	33	)	)	-RRB-
cord-284409-xiyeceib	26	34	.	.	.
cord-284409-xiyeceib	27	1	We	-PRON-	PRP
cord-284409-xiyeceib	27	2	calculated	calculate	VBD
cord-284409-xiyeceib	27	3	the	the	DT
cord-284409-xiyeceib	27	4	number	number	NN
cord-284409-xiyeceib	27	5	of	of	IN
cord-284409-xiyeceib	27	6	amino	amino	NN
cord-284409-xiyeceib	27	7	acid	acid	NN
cord-284409-xiyeceib	27	8	mutations	mutation	NNS
cord-284409-xiyeceib	27	9	per	per	IN
cord-284409-xiyeceib	27	10	heavy	heavy	JJ
cord-284409-xiyeceib	27	11	chain	chain	NN
cord-284409-xiyeceib	27	12	V	v	NN
cord-284409-xiyeceib	27	13	gene	gene	NN
cord-284409-xiyeceib	27	14	,	,	,
cord-284409-xiyeceib	27	15	and	and	CC
cord-284409-xiyeceib	27	16	defined	define	VBD
cord-284409-xiyeceib	27	17	it	-PRON-	PRP
cord-284409-xiyeceib	27	18	as	as	IN
cord-284409-xiyeceib	27	19	antibody	antibody	NN
cord-284409-xiyeceib	27	20	somatic	somatic	JJ
cord-284409-xiyeceib	27	21	mutational	mutational	JJ
cord-284409-xiyeceib	27	22	diversification	diversification	NN
cord-284409-xiyeceib	27	23	(	(	-LRB-
cord-284409-xiyeceib	27	24	ASMD	ASMD	NNP
cord-284409-xiyeceib	27	25	)	)	-RRB-
cord-284409-xiyeceib	27	26	.	.	.
cord-284409-xiyeceib	28	1	We	-PRON-	PRP
cord-284409-xiyeceib	28	2	compared	compare	VBD
cord-284409-xiyeceib	28	3	the	the	DT
cord-284409-xiyeceib	28	4	extent	extent	NN
cord-284409-xiyeceib	28	5	and	and	CC
cord-284409-xiyeceib	28	6	dynamics	dynamic	NNS
cord-284409-xiyeceib	28	7	of	of	IN
cord-284409-xiyeceib	28	8	the	the	DT
cord-284409-xiyeceib	28	9	ASMD	ASMD	NNP
cord-284409-xiyeceib	28	10	between	between	IN
cord-284409-xiyeceib	28	11	HIV-1-specific	HIV-1-specific	NNP
cord-284409-xiyeceib	28	12	mAbs	mAbs	NNP
cord-284409-xiyeceib	28	13	and	and	CC
cord-284409-xiyeceib	28	14	a	a	DT
cord-284409-xiyeceib	28	15	panel	panel	NN
cord-284409-xiyeceib	28	16	of	of	IN
cord-284409-xiyeceib	28	17	SARS	SARS	NNP
cord-284409-xiyeceib	28	18	CoVspecific	CoVspecific	NNP
cord-284409-xiyeceib	28	19	mAbs	mAbs	NNP
cord-284409-xiyeceib	28	20	.	.	.
cord-284409-xiyeceib	29	1	Our	-PRON-	PRP$
cord-284409-xiyeceib	29	2	experiments	experiment	NNS
cord-284409-xiyeceib	29	3	based	base	VBN
cord-284409-xiyeceib	29	4	on	on	IN
cord-284409-xiyeceib	29	5	the	the	DT
cord-284409-xiyeceib	29	6	ASMD	ASMD	NNP
cord-284409-xiyeceib	29	7	predicted	predict	VBD
cord-284409-xiyeceib	29	8	that	that	IN
cord-284409-xiyeceib	29	9	elicitation	elicitation	NN
cord-284409-xiyeceib	29	10	of	of	IN
cord-284409-xiyeceib	29	11	HIV-1-specific	HIV-1-specific	NNP
cord-284409-xiyeceib	29	12	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	29	13	would	would	MD
cord-284409-xiyeceib	29	14	take	take	VB
cord-284409-xiyeceib	29	15	at	at	RB
cord-284409-xiyeceib	29	16	least	least	JJS
cord-284409-xiyeceib	29	17	3	3	CD
cord-284409-xiyeceib	29	18	years	year	NNS
cord-284409-xiyeceib	29	19	.	.	.
cord-284409-xiyeceib	30	1	An	an	DT
cord-284409-xiyeceib	30	2	illustrative	illustrative	JJ
cord-284409-xiyeceib	30	3	mathematical	mathematical	JJ
cord-284409-xiyeceib	30	4	model	model	NN
cord-284409-xiyeceib	30	5	using	use	VBG
cord-284409-xiyeceib	30	6	the	the	DT
cord-284409-xiyeceib	30	7	ASMD	ASMD	NNP
cord-284409-xiyeceib	30	8	rate	rate	NN
cord-284409-xiyeceib	30	9	based	base	VBN
cord-284409-xiyeceib	30	10	on	on	IN
cord-284409-xiyeceib	30	11	www.frontiersin.org	www.frontiersin.org	IN
cord-284409-xiyeceib	30	12	an	an	DT
cord-284409-xiyeceib	30	13	exponential	exponential	JJ
cord-284409-xiyeceib	30	14	time	time	NN
cord-284409-xiyeceib	30	15	dependent	dependent	JJ
cord-284409-xiyeceib	30	16	function	function	NN
cord-284409-xiyeceib	30	17	suggested	suggest	VBD
cord-284409-xiyeceib	30	18	that	that	IN
cord-284409-xiyeceib	30	19	a	a	DT
cord-284409-xiyeceib	30	20	much	much	RB
cord-284409-xiyeceib	30	21	longer	long	JJR
cord-284409-xiyeceib	30	22	time	time	NN
cord-284409-xiyeceib	30	23	would	would	MD
cord-284409-xiyeceib	30	24	be	be	VB
cord-284409-xiyeceib	30	25	needed	need	VBN
cord-284409-xiyeceib	30	26	for	for	IN
cord-284409-xiyeceib	30	27	the	the	DT
cord-284409-xiyeceib	30	28	required	require	VBN
cord-284409-xiyeceib	30	29	maturation	maturation	NN
cord-284409-xiyeceib	30	30	,	,	,
cord-284409-xiyeceib	30	31	unless	unless	IN
cord-284409-xiyeceib	30	32	somatic	somatic	JJ
cord-284409-xiyeceib	30	33	diversification	diversification	NN
cord-284409-xiyeceib	30	34	had	have	VBD
cord-284409-xiyeceib	30	35	already	already	RB
cord-284409-xiyeceib	30	36	been	be	VBN
cord-284409-xiyeceib	30	37	initiated	initiate	VBN
cord-284409-xiyeceib	30	38	from	from	IN
cord-284409-xiyeceib	30	39	an	an	DT
cord-284409-xiyeceib	30	40	intermediate	intermediate	JJ
cord-284409-xiyeceib	30	41	antibody	antibody	NN
cord-284409-xiyeceib	30	42	.	.	.
cord-284409-xiyeceib	31	1	Thus	thus	RB
cord-284409-xiyeceib	31	2	,	,	,
cord-284409-xiyeceib	31	3	all	all	PDT
cord-284409-xiyeceib	31	4	these	these	DT
cord-284409-xiyeceib	31	5	initial	initial	JJ
cord-284409-xiyeceib	31	6	studies	study	NNS
cord-284409-xiyeceib	31	7	corroborated	corroborate	VBD
cord-284409-xiyeceib	31	8	our	-PRON-	PRP$
cord-284409-xiyeceib	31	9	hypothesis	hypothesis	NN
cord-284409-xiyeceib	31	10	that	that	IN
cord-284409-xiyeceib	31	11	the	the	DT
cord-284409-xiyeceib	31	12	infrequent	infrequent	JJ
cord-284409-xiyeceib	31	13	occurrence	occurrence	NN
cord-284409-xiyeceib	31	14	or	or	CC
cord-284409-xiyeceib	31	15	absence	absence	NN
cord-284409-xiyeceib	31	16	of	of	IN
cord-284409-xiyeceib	31	17	bnAbs	bnabs	NN
cord-284409-xiyeceib	31	18	in	in	IN
cord-284409-xiyeceib	31	19	HIV-1-infected	hiv-1-infecte	VBN
cord-284409-xiyeceib	31	20	patients	patient	NNS
cord-284409-xiyeceib	31	21	could	could	MD
cord-284409-xiyeceib	31	22	be	be	VB
cord-284409-xiyeceib	31	23	due	due	JJ
cord-284409-xiyeceib	31	24	,	,	,
cord-284409-xiyeceib	31	25	at	at	IN
cord-284409-xiyeceib	31	26	least	least	JJS
cord-284409-xiyeceib	31	27	in	in	IN
cord-284409-xiyeceib	31	28	part	part	NN
cord-284409-xiyeceib	31	29	,	,	,
cord-284409-xiyeceib	31	30	to	to	IN
cord-284409-xiyeceib	31	31	the	the	DT
cord-284409-xiyeceib	31	32	lack	lack	NN
cord-284409-xiyeceib	31	33	or	or	CC
cord-284409-xiyeceib	31	34	limited	limited	JJ
cord-284409-xiyeceib	31	35	availability	availability	NN
cord-284409-xiyeceib	31	36	of	of	IN
cord-284409-xiyeceib	31	37	B	b	NN
cord-284409-xiyeceib	31	38	cell	cell	NN
cord-284409-xiyeceib	31	39	receptors	receptor	NNS
cord-284409-xiyeceib	31	40	that	that	WDT
cord-284409-xiyeceib	31	41	rapidly	rapidly	RB
cord-284409-xiyeceib	31	42	mature	mature	VBP
cord-284409-xiyeceib	31	43	into	into	IN
cord-284409-xiyeceib	31	44	bnAbs	bnabs	NN
cord-284409-xiyeceib	31	45	.	.	.
cord-284409-xiyeceib	32	1	Therefore	therefore	RB
cord-284409-xiyeceib	32	2	,	,	,
cord-284409-xiyeceib	32	3	we	-PRON-	PRP
cord-284409-xiyeceib	32	4	suggested	suggest	VBD
cord-284409-xiyeceib	32	5	that	that	IN
cord-284409-xiyeceib	32	6	appropriate	appropriate	JJ
cord-284409-xiyeceib	32	7	immunization	immunization	NN
cord-284409-xiyeceib	32	8	protocols	protocol	NNS
cord-284409-xiyeceib	32	9	of	of	IN
cord-284409-xiyeceib	32	10	long	long	JJ
cord-284409-xiyeceib	32	11	duration	duration	NN
cord-284409-xiyeceib	32	12	need	need	VBP
cord-284409-xiyeceib	32	13	to	to	TO
cord-284409-xiyeceib	32	14	be	be	VB
cord-284409-xiyeceib	32	15	developed	develop	VBN
cord-284409-xiyeceib	32	16	using	use	VBG
cord-284409-xiyeceib	32	17	the	the	DT
cord-284409-xiyeceib	32	18	knowledge	knowledge	NN
cord-284409-xiyeceib	32	19	gained	gain	VBN
cord-284409-xiyeceib	32	20	from	from	IN
cord-284409-xiyeceib	32	21	the	the	DT
cord-284409-xiyeceib	32	22	exploration	exploration	NN
cord-284409-xiyeceib	32	23	of	of	IN
cord-284409-xiyeceib	32	24	antibody	antibody	NN
cord-284409-xiyeceib	32	25	maturation	maturation	NN
cord-284409-xiyeceib	32	26	pathways	pathway	NNS
cord-284409-xiyeceib	32	27	in	in	IN
cord-284409-xiyeceib	32	28	humans	human	NNS
cord-284409-xiyeceib	32	29	(	(	-LRB-
cord-284409-xiyeceib	32	30	10	10	CD
cord-284409-xiyeceib	32	31	)	)	-RRB-
cord-284409-xiyeceib	32	32	.	.	.
cord-284409-xiyeceib	33	1	From	from	IN
cord-284409-xiyeceib	33	2	the	the	DT
cord-284409-xiyeceib	33	3	striking	striking	JJ
cord-284409-xiyeceib	33	4	observation	observation	NN
cord-284409-xiyeceib	33	5	that	that	IN
cord-284409-xiyeceib	33	6	all	all	DT
cord-284409-xiyeceib	33	7	known	know	VBN
cord-284409-xiyeceib	33	8	potent	potent	JJ
cord-284409-xiyeceib	33	9	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	33	10	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	33	11	are	be	VBP
cord-284409-xiyeceib	33	12	highly	highly	RB
cord-284409-xiyeceib	33	13	divergent	divergent	JJ
cord-284409-xiyeceib	33	14	from	from	IN
cord-284409-xiyeceib	33	15	their	-PRON-	PRP$
cord-284409-xiyeceib	33	16	putative	putative	JJ
cord-284409-xiyeceib	33	17	germline	germline	JJ
cord-284409-xiyeceib	33	18	predecessors	predecessor	NNS
cord-284409-xiyeceib	33	19	in	in	IN
cord-284409-xiyeceib	33	20	contrast	contrast	NN
cord-284409-xiyeceib	33	21	to	to	IN
cord-284409-xiyeceib	33	22	bnAbs	bnabs	NN
cord-284409-xiyeceib	33	23	against	against	IN
cord-284409-xiyeceib	33	24	henipaviruses	henipaviruses	NNPS
cord-284409-xiyeceib	33	25	and	and	CC
cord-284409-xiyeceib	33	26	SARS	SARS	NNP
cord-284409-xiyeceib	33	27	CoV	CoV	NNP
cord-284409-xiyeceib	33	28	coronavirus	coronavirus	NNP
cord-284409-xiyeceib	33	29	,	,	,
cord-284409-xiyeceib	33	30	we	-PRON-	PRP
cord-284409-xiyeceib	33	31	hypothesized	hypothesize	VBD
cord-284409-xiyeceib	33	32	that	that	IN
cord-284409-xiyeceib	33	33	,	,	,
cord-284409-xiyeceib	33	34	since	since	IN
cord-284409-xiyeceib	33	35	the	the	DT
cord-284409-xiyeceib	33	36	germline	germline	NN
cord-284409-xiyeceib	33	37	antibodies	antibody	NNS
cord-284409-xiyeceib	33	38	are	be	VBP
cord-284409-xiyeceib	33	39	so	so	RB
cord-284409-xiyeceib	33	40	different	different	JJ
cord-284409-xiyeceib	33	41	compared	compare	VBN
cord-284409-xiyeceib	33	42	to	to	IN
cord-284409-xiyeceib	33	43	the	the	DT
cord-284409-xiyeceib	33	44	highly	highly	RB
cord-284409-xiyeceib	33	45	somatically	somatically	RB
cord-284409-xiyeceib	33	46	mutated	mutate	VBD
cord-284409-xiyeceib	33	47	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	33	48	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	33	49	,	,	,
cord-284409-xiyeceib	33	50	they	-PRON-	PRP
cord-284409-xiyeceib	33	51	may	may	MD
cord-284409-xiyeceib	33	52	not	not	RB
cord-284409-xiyeceib	33	53	bind	bind	VB
cord-284409-xiyeceib	33	54	to	to	IN
cord-284409-xiyeceib	33	55	the	the	DT
cord-284409-xiyeceib	33	56	Env	Env	NNP
cord-284409-xiyeceib	33	57	.	.	.
cord-284409-xiyeceib	34	1	This	this	DT
cord-284409-xiyeceib	34	2	led	lead	VBD
cord-284409-xiyeceib	34	3	us	-PRON-	PRP
cord-284409-xiyeceib	34	4	to	to	IN
cord-284409-xiyeceib	34	5	the	the	DT
cord-284409-xiyeceib	34	6	hypothesis	hypothesis	NN
cord-284409-xiyeceib	34	7	that	that	IN
cord-284409-xiyeceib	34	8	the	the	DT
cord-284409-xiyeceib	34	9	immunogenicity	immunogenicity	NN
cord-284409-xiyeceib	34	10	of	of	IN
cord-284409-xiyeceib	34	11	the	the	DT
cord-284409-xiyeceib	34	12	highly	highly	RB
cord-284409-xiyeceib	34	13	conserved	conserved	JJ
cord-284409-xiyeceib	34	14	epitopes	epitope	NNS
cord-284409-xiyeceib	34	15	on	on	IN
cord-284409-xiyeceib	34	16	the	the	DT
cord-284409-xiyeceib	34	17	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	34	18	native	native	JJ
cord-284409-xiyeceib	34	19	envelope	envelope	NN
cord-284409-xiyeceib	34	20	glycoproteins	glycoprotein	NNS
cord-284409-xiyeceib	34	21	(	(	-LRB-
cord-284409-xiyeceib	34	22	Envs	Envs	NNP
cord-284409-xiyeceib	34	23	)	)	-RRB-
cord-284409-xiyeceib	34	24	is	be	VBZ
cord-284409-xiyeceib	34	25	reduced	reduce	VBN
cord-284409-xiyeceib	34	26	or	or	CC
cord-284409-xiyeceib	34	27	eliminated	eliminate	VBN
cord-284409-xiyeceib	34	28	by	by	IN
cord-284409-xiyeceib	34	29	their	-PRON-	PRP$
cord-284409-xiyeceib	34	30	very	very	RB
cord-284409-xiyeceib	34	31	weak	weak	JJ
cord-284409-xiyeceib	34	32	or	or	CC
cord-284409-xiyeceib	34	33	absent	absent	JJ
cord-284409-xiyeceib	34	34	interactions	interaction	NNS
cord-284409-xiyeceib	34	35	with	with	IN
cord-284409-xiyeceib	34	36	germline	germline	JJ
cord-284409-xiyeceib	34	37	antibodies	antibody	NNS
cord-284409-xiyeceib	34	38	,	,	,
cord-284409-xiyeceib	34	39	which	which	WDT
cord-284409-xiyeceib	34	40	could	could	MD
cord-284409-xiyeceib	34	41	not	not	RB
cord-284409-xiyeceib	34	42	initiate	initiate	VB
cord-284409-xiyeceib	34	43	and/or	and/or	CC
cord-284409-xiyeceib	34	44	sustain	sustain	VB
cord-284409-xiyeceib	34	45	immune	immune	JJ
cord-284409-xiyeceib	34	46	responses	response	NNS
cord-284409-xiyeceib	34	47	leading	lead	VBG
cord-284409-xiyeceib	34	48	to	to	IN
cord-284409-xiyeceib	34	49	elicitation	elicitation	NN
cord-284409-xiyeceib	34	50	of	of	IN
cord-284409-xiyeceib	34	51	bnAbs	bnabs	NN
cord-284409-xiyeceib	34	52	:	:	:
cord-284409-xiyeceib	34	53	even	even	RB
cord-284409-xiyeceib	34	54	if	if	IN
cord-284409-xiyeceib	34	55	immune	immune	JJ
cord-284409-xiyeceib	34	56	responses	response	NNS
cord-284409-xiyeceib	34	57	are	be	VBP
cord-284409-xiyeceib	34	58	initiated	initiate	VBN
cord-284409-xiyeceib	34	59	and	and	CC
cord-284409-xiyeceib	34	60	sustained	sustain	VBN
cord-284409-xiyeceib	34	61	,	,	,
cord-284409-xiyeceib	34	62	the	the	DT
cord-284409-xiyeceib	34	63	maturation	maturation	NN
cord-284409-xiyeceib	34	64	pathways	pathway	NNS
cord-284409-xiyeceib	34	65	are	be	VBP
cord-284409-xiyeceib	34	66	so	so	RB
cord-284409-xiyeceib	34	67	complex	complex	JJ
cord-284409-xiyeceib	34	68	that	that	WDT
cord-284409-xiyeceib	34	69	help	help	VBP
cord-284409-xiyeceib	34	70	and	and	CC
cord-284409-xiyeceib	34	71	long	long	JJ
cord-284409-xiyeceib	34	72	times	time	NNS
cord-284409-xiyeceib	34	73	may	may	MD
cord-284409-xiyeceib	34	74	be	be	VB
cord-284409-xiyeceib	34	75	needed	need	VBN
cord-284409-xiyeceib	34	76	for	for	IN
cord-284409-xiyeceib	34	77	their	-PRON-	PRP$
cord-284409-xiyeceib	34	78	elicitation	elicitation	NN
cord-284409-xiyeceib	34	79	.	.	.
cord-284409-xiyeceib	35	1	To	to	TO
cord-284409-xiyeceib	35	2	test	test	VB
cord-284409-xiyeceib	35	3	our	-PRON-	PRP$
cord-284409-xiyeceib	35	4	antibody	antibody	NN
cord-284409-xiyeceib	35	5	germline	germline	NN
cord-284409-xiyeceib	35	6	/	/	SYM
cord-284409-xiyeceib	35	7	maturation	maturation	NN
cord-284409-xiyeceib	35	8	hypothesis	hypothesis	NN
cord-284409-xiyeceib	35	9	,	,	,
cord-284409-xiyeceib	35	10	we	-PRON-	PRP
cord-284409-xiyeceib	35	11	designed	design	VBD
cord-284409-xiyeceib	35	12	germline	germline	NN
cord-284409-xiyeceib	35	13	-	-	HYPH
cord-284409-xiyeceib	35	14	like	like	JJ
cord-284409-xiyeceib	35	15	antibodies	antibody	NNS
cord-284409-xiyeceib	35	16	corresponding	correspond	VBG
cord-284409-xiyeceib	35	17	to	to	IN
cord-284409-xiyeceib	35	18	the	the	DT
cord-284409-xiyeceib	35	19	known	know	VBN
cord-284409-xiyeceib	35	20	bnAbs	bnabs	NN
cord-284409-xiyeceib	35	21	b12	b12	NN
cord-284409-xiyeceib	35	22	,	,	,
cord-284409-xiyeceib	35	23	2G12	2g12	CD
cord-284409-xiyeceib	35	24	,	,	,
cord-284409-xiyeceib	35	25	2F5	2f5	CD
cord-284409-xiyeceib	35	26	,	,	,
cord-284409-xiyeceib	35	27	X5	X5	NNP
cord-284409-xiyeceib	35	28	,	,	,
cord-284409-xiyeceib	35	29	m44	m44	NNP
cord-284409-xiyeceib	35	30	,	,	,
cord-284409-xiyeceib	35	31	and	and	CC
cord-284409-xiyeceib	35	32	m46	m46	NN
cord-284409-xiyeceib	35	33	(	(	-LRB-
cord-284409-xiyeceib	35	34	the	the	DT
cord-284409-xiyeceib	35	35	latter	latter	JJ
cord-284409-xiyeceib	35	36	three	three	CD
cord-284409-xiyeceib	35	37	antibodies	antibody	NNS
cord-284409-xiyeceib	35	38	were	be	VBD
cord-284409-xiyeceib	35	39	discovered	discover	VBN
cord-284409-xiyeceib	35	40	in	in	IN
cord-284409-xiyeceib	35	41	our	-PRON-	PRP$
cord-284409-xiyeceib	35	42	laboratory	laboratory	NN
cord-284409-xiyeceib	35	43	and	and	CC
cord-284409-xiyeceib	35	44	possess	possess	VB
cord-284409-xiyeceib	35	45	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	35	46	cross	cross	NN
cord-284409-xiyeceib	35	47	-	-	NN
cord-284409-xiyeceib	35	48	reactivity	reactivity	NN
cord-284409-xiyeceib	35	49	with	with	IN
cord-284409-xiyeceib	35	50	moderate	moderate	JJ
cord-284409-xiyeceib	35	51	neutralizing	neutralize	VBG
cord-284409-xiyeceib	35	52	activities	activity	NNS
cord-284409-xiyeceib	35	53	)	)	-RRB-
cord-284409-xiyeceib	35	54	and	and	CC
cord-284409-xiyeceib	35	55	evaluated	evaluate	VBD
cord-284409-xiyeceib	35	56	them	-PRON-	PRP
cord-284409-xiyeceib	35	57	for	for	IN
cord-284409-xiyeceib	35	58	binding	bind	VBG
cord-284409-xiyeceib	35	59	to	to	IN
cord-284409-xiyeceib	35	60	Envs	Envs	NNP
cord-284409-xiyeceib	35	61	(	(	-LRB-
cord-284409-xiyeceib	35	62	11	11	CD
cord-284409-xiyeceib	35	63	)	)	-RRB-
cord-284409-xiyeceib	35	64	.	.	.
cord-284409-xiyeceib	36	1	We	-PRON-	PRP
cord-284409-xiyeceib	36	2	found	find	VBD
cord-284409-xiyeceib	36	3	that	that	IN
cord-284409-xiyeceib	36	4	while	while	IN
cord-284409-xiyeceib	36	5	germline	germline	NN
cord-284409-xiyeceib	36	6	-	-	HYPH
cord-284409-xiyeceib	36	7	like	like	JJ
cord-284409-xiyeceib	36	8	X5	X5	NNP
cord-284409-xiyeceib	36	9	,	,	,
cord-284409-xiyeceib	36	10	m44	m44	NNP
cord-284409-xiyeceib	36	11	,	,	,
cord-284409-xiyeceib	36	12	and	and	CC
cord-284409-xiyeceib	36	13	m46	m46	NN
cord-284409-xiyeceib	36	14	bound	bind	VBN
cord-284409-xiyeceib	36	15	to	to	IN
cord-284409-xiyeceib	36	16	Envs	Envs	NNP
cord-284409-xiyeceib	36	17	with	with	IN
cord-284409-xiyeceib	36	18	relatively	relatively	RB
cord-284409-xiyeceib	36	19	high	high	JJ
cord-284409-xiyeceib	36	20	affinity	affinity	NN
cord-284409-xiyeceib	36	21	,	,	,
cord-284409-xiyeceib	36	22	the	the	DT
cord-284409-xiyeceib	36	23	germline	germline	NN
cord-284409-xiyeceib	36	24	-	-	HYPH
cord-284409-xiyeceib	36	25	like	like	JJ
cord-284409-xiyeceib	36	26	precursors	precursor	NNS
cord-284409-xiyeceib	36	27	of	of	IN
cord-284409-xiyeceib	36	28	b12	b12	NN
cord-284409-xiyeceib	36	29	,	,	,
cord-284409-xiyeceib	36	30	2G12	2g12	CD
cord-284409-xiyeceib	36	31	,	,	,
cord-284409-xiyeceib	36	32	and	and	CC
cord-284409-xiyeceib	36	33	2F5	2f5	CD
cord-284409-xiyeceib	36	34	failed	fail	VBD
cord-284409-xiyeceib	36	35	to	to	TO
cord-284409-xiyeceib	36	36	bind	bind	VB
cord-284409-xiyeceib	36	37	Envs	Envs	NNP
cord-284409-xiyeceib	36	38	in	in	IN
cord-284409-xiyeceib	36	39	an	an	DT
cord-284409-xiyeceib	36	40	ELISA	ELISA	NNP
cord-284409-xiyeceib	36	41	assay	assay	NN
cord-284409-xiyeceib	36	42	although	although	IN
cord-284409-xiyeceib	36	43	their	-PRON-	PRP$
cord-284409-xiyeceib	36	44	corresponding	correspond	VBG
cord-284409-xiyeceib	36	45	mature	mature	JJ
cord-284409-xiyeceib	36	46	bnAbs	bnabs	NN
cord-284409-xiyeceib	36	47	bound	bind	VBN
cord-284409-xiyeceib	36	48	strongly	strongly	RB
cord-284409-xiyeceib	36	49	.	.	.
cord-284409-xiyeceib	37	1	These	these	DT
cord-284409-xiyeceib	37	2	results	result	NNS
cord-284409-xiyeceib	37	3	provided	provide	VBD
cord-284409-xiyeceib	37	4	initial	initial	JJ
cord-284409-xiyeceib	37	5	evidence	evidence	NN
cord-284409-xiyeceib	37	6	that	that	IN
cord-284409-xiyeceib	37	7	the	the	DT
cord-284409-xiyeceib	37	8	Env	Env	NNP
cord-284409-xiyeceib	37	9	structures	structure	NNS
cord-284409-xiyeceib	37	10	containing	contain	VBG
cord-284409-xiyeceib	37	11	conserved	conserved	JJ
cord-284409-xiyeceib	37	12	epitopes	epitope	NNS
cord-284409-xiyeceib	37	13	might	may	MD
cord-284409-xiyeceib	37	14	not	not	RB
cord-284409-xiyeceib	37	15	initiate	initiate	VB
cord-284409-xiyeceib	37	16	humoral	humoral	JJ
cord-284409-xiyeceib	37	17	responses	response	NNS
cord-284409-xiyeceib	37	18	due	due	JJ
cord-284409-xiyeceib	37	19	to	to	IN
cord-284409-xiyeceib	37	20	limited	limited	JJ
cord-284409-xiyeceib	37	21	or	or	CC
cord-284409-xiyeceib	37	22	absent	absent	JJ
cord-284409-xiyeceib	37	23	binding	binding	NN
cord-284409-xiyeceib	37	24	to	to	IN
cord-284409-xiyeceib	37	25	the	the	DT
cord-284409-xiyeceib	37	26	germline	germline	JJ
cord-284409-xiyeceib	37	27	precursors	precursor	NNS
cord-284409-xiyeceib	37	28	of	of	IN
cord-284409-xiyeceib	37	29	bnAbs	bnabs	NN
cord-284409-xiyeceib	37	30	.	.	.
cord-284409-xiyeceib	38	1	These	these	DT
cord-284409-xiyeceib	38	2	germline	germline	JJ
cord-284409-xiyeceib	38	3	precursors	precursor	NNS
cord-284409-xiyeceib	38	4	may	may	MD
cord-284409-xiyeceib	38	5	also	also	RB
cord-284409-xiyeceib	38	6	be	be	VB
cord-284409-xiyeceib	38	7	of	of	IN
cord-284409-xiyeceib	38	8	limited	limited	JJ
cord-284409-xiyeceib	38	9	availability	availability	NN
cord-284409-xiyeceib	38	10	as	as	IN
cord-284409-xiyeceib	38	11	recently	recently	RB
cord-284409-xiyeceib	38	12	reported	report	VBN
cord-284409-xiyeceib	38	13	(	(	-LRB-
cord-284409-xiyeceib	38	14	12	12	CD
cord-284409-xiyeceib	38	15	)	)	-RRB-
cord-284409-xiyeceib	38	16	.	.	.
cord-284409-xiyeceib	39	1	Following	follow	VBG
cord-284409-xiyeceib	39	2	that	that	DT
cord-284409-xiyeceib	39	3	initial	initial	JJ
cord-284409-xiyeceib	39	4	study	study	NN
cord-284409-xiyeceib	39	5	,	,	,
cord-284409-xiyeceib	39	6	we	-PRON-	PRP
cord-284409-xiyeceib	39	7	expanded	expand	VBD
cord-284409-xiyeceib	39	8	our	-PRON-	PRP$
cord-284409-xiyeceib	39	9	investigation	investigation	NN
cord-284409-xiyeceib	39	10	to	to	IN
cord-284409-xiyeceib	39	11	different	different	JJ
cord-284409-xiyeceib	39	12	variants	variant	NNS
cord-284409-xiyeceib	39	13	of	of	IN
cord-284409-xiyeceib	39	14	the	the	DT
cord-284409-xiyeceib	39	15	two	two	CD
cord-284409-xiyeceib	39	16	different	different	JJ
cord-284409-xiyeceib	39	17	antibodies	antibody	NNS
cord-284409-xiyeceib	39	18	(	(	-LRB-
cord-284409-xiyeceib	39	19	b12	b12	NN
cord-284409-xiyeceib	39	20	and	and	CC
cord-284409-xiyeceib	39	21	X5	X5	NNP
cord-284409-xiyeceib	39	22	)	)	-RRB-
cord-284409-xiyeceib	39	23	including	include	VBG
cord-284409-xiyeceib	39	24	their	-PRON-	PRP$
cord-284409-xiyeceib	39	25	closest	close	JJS
cord-284409-xiyeceib	39	26	germline	germline	JJ
cord-284409-xiyeceib	39	27	counterparts	counterpart	NNS
cord-284409-xiyeceib	39	28	and	and	CC
cord-284409-xiyeceib	39	29	several	several	JJ
cord-284409-xiyeceib	39	30	germline	germline	NN
cord-284409-xiyeceib	39	31	-	-	HYPH
cord-284409-xiyeceib	39	32	like	like	JJ
cord-284409-xiyeceib	39	33	intermediates	intermediate	NNS
cord-284409-xiyeceib	39	34	(	(	-LRB-
cord-284409-xiyeceib	39	35	13	13	CD
cord-284409-xiyeceib	39	36	)	)	-RRB-
cord-284409-xiyeceib	39	37	.	.	.
cord-284409-xiyeceib	40	1	The	the	DT
cord-284409-xiyeceib	40	2	experiments	experiment	NNS
cord-284409-xiyeceib	40	3	showed	show	VBD
cord-284409-xiyeceib	40	4	that	that	IN
cord-284409-xiyeceib	40	5	b12	b12	NN
cord-284409-xiyeceib	40	6	intermediate	intermediate	JJ
cord-284409-xiyeceib	40	7	antibodies	antibody	NNS
cord-284409-xiyeceib	40	8	neutralized	neutralize	VBD
cord-284409-xiyeceib	40	9	only	only	RB
cord-284409-xiyeceib	40	10	some	some	DT
cord-284409-xiyeceib	40	11	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	40	12	isolates	isolate	VBZ
cord-284409-xiyeceib	40	13	with	with	IN
cord-284409-xiyeceib	40	14	relatively	relatively	RB
cord-284409-xiyeceib	40	15	weak	weak	JJ
cord-284409-xiyeceib	40	16	potency	potency	NN
cord-284409-xiyeceib	40	17	.	.	.
cord-284409-xiyeceib	41	1	In	in	IN
cord-284409-xiyeceib	41	2	contrast	contrast	NN
cord-284409-xiyeceib	41	3	,	,	,
cord-284409-xiyeceib	41	4	intermediates	intermediate	NNS
cord-284409-xiyeceib	41	5	of	of	IN
cord-284409-xiyeceib	41	6	X5	X5	NNP
cord-284409-xiyeceib	41	7	neutralized	neutralize	VBD
cord-284409-xiyeceib	41	8	a	a	DT
cord-284409-xiyeceib	41	9	subset	subset	NN
cord-284409-xiyeceib	41	10	of	of	IN
cord-284409-xiyeceib	41	11	the	the	DT
cord-284409-xiyeceib	41	12	tested	test	VBN
cord-284409-xiyeceib	41	13	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	41	14	isolates	isolate	VBZ
cord-284409-xiyeceib	41	15	with	with	IN
cord-284409-xiyeceib	41	16	efficiencies	efficiency	NNS
cord-284409-xiyeceib	41	17	comparable	comparable	JJ
cord-284409-xiyeceib	41	18	to	to	IN
cord-284409-xiyeceib	41	19	those	those	DT
cord-284409-xiyeceib	41	20	of	of	IN
cord-284409-xiyeceib	41	21	the	the	DT
cord-284409-xiyeceib	41	22	matured	mature	VBN
cord-284409-xiyeceib	41	23	X5	X5	NNP
cord-284409-xiyeceib	41	24	.	.	.
cord-284409-xiyeceib	42	1	These	these	DT
cord-284409-xiyeceib	42	2	results	result	NNS
cord-284409-xiyeceib	42	3	helped	help	VBD
cord-284409-xiyeceib	42	4	explain	explain	VB
cord-284409-xiyeceib	42	5	the	the	DT
cord-284409-xiyeceib	42	6	relatively	relatively	RB
cord-284409-xiyeceib	42	7	high	high	JJ
cord-284409-xiyeceib	42	8	immunogenicity	immunogenicity	NN
cord-284409-xiyeceib	42	9	of	of	IN
cord-284409-xiyeceib	42	10	the	the	DT
cord-284409-xiyeceib	42	11	coreceptor	coreceptor	NN
cord-284409-xiyeceib	42	12	binding	bind	VBG
cord-284409-xiyeceib	42	13	site	site	NN
cord-284409-xiyeceib	42	14	on	on	IN
cord-284409-xiyeceib	42	15	gp120	gp120	NNP
cord-284409-xiyeceib	42	16	and	and	CC
cord-284409-xiyeceib	42	17	the	the	DT
cord-284409-xiyeceib	42	18	abundance	abundance	NN
cord-284409-xiyeceib	42	19	of	of	IN
cord-284409-xiyeceib	42	20	CD4-induced	cd4-induce	VBN
cord-284409-xiyeceib	42	21	(	(	-LRB-
cord-284409-xiyeceib	42	22	CD4i	CD4i	NNP
cord-284409-xiyeceib	42	23	)	)	-RRB-
cord-284409-xiyeceib	42	24	antibodies	antibody	NNS
cord-284409-xiyeceib	42	25	in	in	IN
cord-284409-xiyeceib	42	26	HIV-1-infected	hiv-1-infecte	VBN
cord-284409-xiyeceib	42	27	patients	patient	NNS
cord-284409-xiyeceib	42	28	(	(	-LRB-
cord-284409-xiyeceib	42	29	X5	X5	NNP
cord-284409-xiyeceib	42	30	is	be	VBZ
cord-284409-xiyeceib	42	31	a	a	DT
cord-284409-xiyeceib	42	32	CD4i	CD4i	NNP
cord-284409-xiyeceib	42	33	antibody	antibody	NN
cord-284409-xiyeceib	42	34	)	)	-RRB-
cord-284409-xiyeceib	42	35	as	as	RB
cord-284409-xiyeceib	42	36	well	well	RB
cord-284409-xiyeceib	42	37	as	as	IN
cord-284409-xiyeceib	42	38	the	the	DT
cord-284409-xiyeceib	42	39	maturation	maturation	NN
cord-284409-xiyeceib	42	40	pathway	pathway	NN
cord-284409-xiyeceib	42	41	of	of	IN
cord-284409-xiyeceib	42	42	X5	X5	NNP
cord-284409-xiyeceib	42	43	.	.	.
cord-284409-xiyeceib	43	1	In	in	IN
cord-284409-xiyeceib	43	2	the	the	DT
cord-284409-xiyeceib	43	3	case	case	NN
cord-284409-xiyeceib	43	4	of	of	IN
cord-284409-xiyeceib	43	5	b12	b12	NN
cord-284409-xiyeceib	43	6	,	,	,
cord-284409-xiyeceib	43	7	germlinelike	germlinelike	NNP
cord-284409-xiyeceib	43	8	intermediates	intermediate	NNS
cord-284409-xiyeceib	43	9	along	along	IN
cord-284409-xiyeceib	43	10	the	the	DT
cord-284409-xiyeceib	43	11	maturation	maturation	NN
cord-284409-xiyeceib	43	12	pathway	pathway	NN
cord-284409-xiyeceib	43	13	were	be	VBD
cord-284409-xiyeceib	43	14	shown	show	VBN
cord-284409-xiyeceib	43	15	to	to	IN
cord-284409-xiyeceib	43	16	not	not	RB
cord-284409-xiyeceib	43	17	only	only	RB
cord-284409-xiyeceib	43	18	bind	bind	VB
cord-284409-xiyeceib	43	19	some	some	DT
cord-284409-xiyeceib	43	20	Envs	Envs	NNP
cord-284409-xiyeceib	43	21	but	but	CC
cord-284409-xiyeceib	43	22	also	also	RB
cord-284409-xiyeceib	43	23	human	human	JJ
cord-284409-xiyeceib	43	24	self	self	NN
cord-284409-xiyeceib	43	25	antigens	antigen	NNS
cord-284409-xiyeceib	43	26	,	,	,
cord-284409-xiyeceib	43	27	suggesting	suggest	VBG
cord-284409-xiyeceib	43	28	that	that	IN
cord-284409-xiyeceib	43	29	antigens	antigen	NNS
cord-284409-xiyeceib	43	30	other	other	JJ
cord-284409-xiyeceib	43	31	than	than	IN
cord-284409-xiyeceib	43	32	the	the	DT
cord-284409-xiyeceib	43	33	Envs	Envs	NNP
cord-284409-xiyeceib	43	34	could	could	MD
cord-284409-xiyeceib	43	35	help	help	VB
cord-284409-xiyeceib	43	36	guide	guide	VB
cord-284409-xiyeceib	43	37	the	the	DT
cord-284409-xiyeceib	43	38	immune	immune	JJ
cord-284409-xiyeceib	43	39	system	system	NN
cord-284409-xiyeceib	43	40	through	through	IN
cord-284409-xiyeceib	43	41	the	the	DT
cord-284409-xiyeceib	43	42	b12	b12	NN
cord-284409-xiyeceib	43	43	maturation	maturation	NN
cord-284409-xiyeceib	43	44	pathway	pathway	NN
cord-284409-xiyeceib	43	45	.	.	.
cord-284409-xiyeceib	44	1	Therefore	therefore	RB
cord-284409-xiyeceib	44	2	,	,	,
cord-284409-xiyeceib	44	3	we	-PRON-	PRP
cord-284409-xiyeceib	44	4	proposed	propose	VBD
cord-284409-xiyeceib	44	5	a	a	DT
cord-284409-xiyeceib	44	6	conceptually	conceptually	RB
cord-284409-xiyeceib	44	7	new	new	JJ
cord-284409-xiyeceib	44	8	vaccination	vaccination	NN
cord-284409-xiyeceib	44	9	approach	approach	NN
cord-284409-xiyeceib	44	10	,	,	,
cord-284409-xiyeceib	44	11	in	in	IN
cord-284409-xiyeceib	44	12	which	which	WDT
cord-284409-xiyeceib	44	13	it	-PRON-	PRP
cord-284409-xiyeceib	44	14	is	be	VBZ
cord-284409-xiyeceib	44	15	critical	critical	JJ
cord-284409-xiyeceib	44	16	to	to	TO
cord-284409-xiyeceib	44	17	identify	identify	VB
cord-284409-xiyeceib	44	18	primary	primary	JJ
cord-284409-xiyeceib	44	19	immunogens	immunogen	NNS
cord-284409-xiyeceib	44	20	that	that	WDT
cord-284409-xiyeceib	44	21	bind	bind	VBP
cord-284409-xiyeceib	44	22	to	to	IN
cord-284409-xiyeceib	44	23	the	the	DT
cord-284409-xiyeceib	44	24	germline	germline	JJ
cord-284409-xiyeceib	44	25	antibodies	antibody	NNS
cord-284409-xiyeceib	44	26	that	that	WDT
cord-284409-xiyeceib	44	27	are	be	VBP
cord-284409-xiyeceib	44	28	predecessors	predecessor	NNS
cord-284409-xiyeceib	44	29	of	of	IN
cord-284409-xiyeceib	44	30	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	44	31	.	.	.
cord-284409-xiyeceib	45	1	If	if	IN
cord-284409-xiyeceib	45	2	needed	need	VBN
cord-284409-xiyeceib	45	3	,	,	,
cord-284409-xiyeceib	45	4	these	these	DT
cord-284409-xiyeceib	45	5	immunogens	immunogen	NNS
cord-284409-xiyeceib	45	6	should	should	MD
cord-284409-xiyeceib	45	7	be	be	VB
cord-284409-xiyeceib	45	8	combined	combine	VBN
cord-284409-xiyeceib	45	9	with	with	IN
cord-284409-xiyeceib	45	10	secondary	secondary	JJ
cord-284409-xiyeceib	45	11	immunogens	immunogen	NNS
cord-284409-xiyeceib	45	12	that	that	WDT
cord-284409-xiyeceib	45	13	recognize	recognize	VBP
cord-284409-xiyeceib	45	14	intermediate	intermediate	JJ
cord-284409-xiyeceib	45	15	and/or	and/or	CC
cord-284409-xiyeceib	45	16	matured	matured	JJ
cord-284409-xiyeceib	45	17	antibodies	antibody	NNS
cord-284409-xiyeceib	45	18	to	to	TO
cord-284409-xiyeceib	45	19	guide	guide	VB
cord-284409-xiyeceib	45	20	the	the	DT
cord-284409-xiyeceib	45	21	immune	immune	JJ
cord-284409-xiyeceib	45	22	system	system	NN
cord-284409-xiyeceib	45	23	through	through	IN
cord-284409-xiyeceib	45	24	the	the	DT
cord-284409-xiyeceib	45	25	prolonged	prolonged	JJ
cord-284409-xiyeceib	45	26	,	,	,
cord-284409-xiyeceib	45	27	complex	complex	JJ
cord-284409-xiyeceib	45	28	maturation	maturation	NN
cord-284409-xiyeceib	45	29	pathways	pathway	NNS
cord-284409-xiyeceib	45	30	(	(	-LRB-
cord-284409-xiyeceib	45	31	14	14	CD
cord-284409-xiyeceib	45	32	)	)	-RRB-
cord-284409-xiyeceib	45	33	.	.	.
cord-284409-xiyeceib	46	1	In	in	IN
cord-284409-xiyeceib	46	2	this	this	DT
cord-284409-xiyeceib	46	3	respect	respect	NN
cord-284409-xiyeceib	46	4	,	,	,
cord-284409-xiyeceib	46	5	we	-PRON-	PRP
cord-284409-xiyeceib	46	6	envisioned	envision	VBD
cord-284409-xiyeceib	46	7	that	that	IN
cord-284409-xiyeceib	46	8	the	the	DT
cord-284409-xiyeceib	46	9	knowledge	knowledge	NN
cord-284409-xiyeceib	46	10	of	of	IN
cord-284409-xiyeceib	46	11	human	human	JJ
cord-284409-xiyeceib	46	12	antibodyomes	antibodyome	NNS
cord-284409-xiyeceib	46	13	would	would	MD
cord-284409-xiyeceib	46	14	become	become	VB
cord-284409-xiyeceib	46	15	indispensable	indispensable	JJ
cord-284409-xiyeceib	46	16	to	to	TO
cord-284409-xiyeceib	46	17	elucidate	elucidate	VB
cord-284409-xiyeceib	46	18	the	the	DT
cord-284409-xiyeceib	46	19	origin	origin	NN
cord-284409-xiyeceib	46	20	,	,	,
cord-284409-xiyeceib	46	21	diversity	diversity	NN
cord-284409-xiyeceib	46	22	,	,	,
cord-284409-xiyeceib	46	23	and	and	CC
cord-284409-xiyeceib	46	24	maturation	maturation	NN
cord-284409-xiyeceib	46	25	pathways	pathway	NNS
cord-284409-xiyeceib	46	26	of	of	IN
cord-284409-xiyeceib	46	27	bnAbs	bnabs	NN
cord-284409-xiyeceib	46	28	and	and	CC
cord-284409-xiyeceib	46	29	discover	discover	VB
cord-284409-xiyeceib	46	30	germline	germline	NN
cord-284409-xiyeceib	46	31	-	-	HYPH
cord-284409-xiyeceib	46	32	like	like	JJ
cord-284409-xiyeceib	46	33	intermediates	intermediate	NNS
cord-284409-xiyeceib	46	34	of	of	IN
cord-284409-xiyeceib	46	35	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	46	36	that	that	WDT
cord-284409-xiyeceib	46	37	could	could	MD
cord-284409-xiyeceib	46	38	provide	provide	VB
cord-284409-xiyeceib	46	39	a	a	DT
cord-284409-xiyeceib	46	40	basis	basis	NN
cord-284409-xiyeceib	46	41	for	for	IN
cord-284409-xiyeceib	46	42	the	the	DT
cord-284409-xiyeceib	46	43	design	design	NN
cord-284409-xiyeceib	46	44	of	of	IN
cord-284409-xiyeceib	46	45	novel	novel	JJ
cord-284409-xiyeceib	46	46	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	46	47	vaccine	vaccine	NN
cord-284409-xiyeceib	46	48	immunogens	immunogen	NNS
cord-284409-xiyeceib	46	49	(	(	-LRB-
cord-284409-xiyeceib	46	50	14	14	CD
cord-284409-xiyeceib	46	51	,	,	,
cord-284409-xiyeceib	46	52	15	15	CD
cord-284409-xiyeceib	46	53	)	)	-RRB-
cord-284409-xiyeceib	46	54	.	.	.
cord-284409-xiyeceib	47	1	In	in	IN
cord-284409-xiyeceib	47	2	recent	recent	JJ
cord-284409-xiyeceib	47	3	years	year	NNS
cord-284409-xiyeceib	47	4	,	,	,
cord-284409-xiyeceib	47	5	several	several	JJ
cord-284409-xiyeceib	47	6	groups	group	NNS
cord-284409-xiyeceib	47	7	have	have	VBP
cord-284409-xiyeceib	47	8	reported	report	VBN
cord-284409-xiyeceib	47	9	a	a	DT
cord-284409-xiyeceib	47	10	number	number	NN
cord-284409-xiyeceib	47	11	of	of	IN
cord-284409-xiyeceib	47	12	new	new	JJ
cord-284409-xiyeceib	47	13	bnAbs	bnabs	NN
cord-284409-xiyeceib	47	14	that	that	WDT
cord-284409-xiyeceib	47	15	were	be	VBD
cord-284409-xiyeceib	47	16	identified	identify	VBN
cord-284409-xiyeceib	47	17	from	from	IN
cord-284409-xiyeceib	47	18	multiple	multiple	JJ
cord-284409-xiyeceib	47	19	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	47	20	infected	infect	VBN
cord-284409-xiyeceib	47	21	individuals	individual	NNS
cord-284409-xiyeceib	47	22	using	use	VBG
cord-284409-xiyeceib	47	23	designed	design	VBN
cord-284409-xiyeceib	47	24	novel	novel	JJ
cord-284409-xiyeceib	47	25	antigen	antigen	NN
cord-284409-xiyeceib	47	26	baits	bait	NNS
cord-284409-xiyeceib	47	27	and	and	CC
cord-284409-xiyeceib	47	28	advanced	advanced	JJ
cord-284409-xiyeceib	47	29	technologies	technology	NNS
cord-284409-xiyeceib	47	30	implemented	implement	VBN
cord-284409-xiyeceib	47	31	in	in	IN
cord-284409-xiyeceib	47	32	isolating	isolate	VBG
cord-284409-xiyeceib	47	33	human	human	JJ
cord-284409-xiyeceib	47	34	mAbs	mAbs	NNP
cord-284409-xiyeceib	47	35	and	and	CC
cord-284409-xiyeceib	47	36	high	high	JJ
cord-284409-xiyeceib	47	37	-	-	HYPH
cord-284409-xiyeceib	47	38	throughput	throughput	NN
cord-284409-xiyeceib	47	39	sequencing	sequencing	NN
cord-284409-xiyeceib	47	40	(	(	-LRB-
cord-284409-xiyeceib	47	41	16	16	CD
cord-284409-xiyeceib	47	42	)	)	-RRB-
cord-284409-xiyeceib	47	43	.	.	.
cord-284409-xiyeceib	48	1	Particularly	particularly	RB
cord-284409-xiyeceib	48	2	,	,	,
cord-284409-xiyeceib	48	3	Haynes	Haynes	NNP
cord-284409-xiyeceib	48	4	,	,	,
cord-284409-xiyeceib	48	5	Kwong	Kwong	NNP
cord-284409-xiyeceib	48	6	,	,	,
cord-284409-xiyeceib	48	7	Stamatatos	Stamatatos	NNP
cord-284409-xiyeceib	48	8	,	,	,
cord-284409-xiyeceib	48	9	Scheif	Scheif	NNP
cord-284409-xiyeceib	48	10	et	et	NNP
cord-284409-xiyeceib	48	11	al	al	NNP
cord-284409-xiyeceib	48	12	.	.	NNP
cord-284409-xiyeceib	48	13	have	have	VBP
cord-284409-xiyeceib	48	14	dealt	deal	VBN
cord-284409-xiyeceib	48	15	with	with	IN
cord-284409-xiyeceib	48	16	a	a	DT
cord-284409-xiyeceib	48	17	large	large	JJ
cord-284409-xiyeceib	48	18	amount	amount	NN
cord-284409-xiyeceib	48	19	of	of	IN
cord-284409-xiyeceib	48	20	data	datum	NNS
cord-284409-xiyeceib	48	21	delineating	delineate	VBG
cord-284409-xiyeceib	48	22	structural	structural	JJ
cord-284409-xiyeceib	48	23	,	,	,
cord-284409-xiyeceib	48	24	genetic	genetic	JJ
cord-284409-xiyeceib	48	25	determinants	determinant	NNS
cord-284409-xiyeceib	48	26	,	,	,
cord-284409-xiyeceib	48	27	and	and	CC
cord-284409-xiyeceib	48	28	maturation	maturation	NN
cord-284409-xiyeceib	48	29	pathways	pathway	NNS
cord-284409-xiyeceib	48	30	of	of	IN
cord-284409-xiyeceib	48	31	different	different	JJ
cord-284409-xiyeceib	48	32	bnAbs	bnabs	NN
cord-284409-xiyeceib	48	33	.	.	.
cord-284409-xiyeceib	49	1	These	these	DT
cord-284409-xiyeceib	49	2	studies	study	NNS
cord-284409-xiyeceib	49	3	not	not	RB
cord-284409-xiyeceib	49	4	only	only	RB
cord-284409-xiyeceib	49	5	confirmed	confirm	VBD
cord-284409-xiyeceib	49	6	our	-PRON-	PRP$
cord-284409-xiyeceib	49	7	previous	previous	JJ
cord-284409-xiyeceib	49	8	findings	finding	NNS
cord-284409-xiyeceib	49	9	that	that	IN
cord-284409-xiyeceib	49	10	the	the	DT
cord-284409-xiyeceib	49	11	Envs	Envs	NNP
cord-284409-xiyeceib	49	12	fail	fail	VB
cord-284409-xiyeceib	49	13	to	to	TO
cord-284409-xiyeceib	49	14	engage	engage	VB
cord-284409-xiyeceib	49	15	germline	germline	JJ
cord-284409-xiyeceib	49	16	versions	version	NNS
cord-284409-xiyeceib	49	17	of	of	IN
cord-284409-xiyeceib	49	18	bnAbs	bnabs	NN
cord-284409-xiyeceib	49	19	but	but	CC
cord-284409-xiyeceib	49	20	also	also	RB
cord-284409-xiyeceib	49	21	suggested	suggest	VBD
cord-284409-xiyeceib	49	22	possible	possible	JJ
cord-284409-xiyeceib	49	23	holes	hole	NNS
cord-284409-xiyeceib	49	24	in	in	IN
cord-284409-xiyeceib	49	25	B	b	NN
cord-284409-xiyeceib	49	26	cell	cell	NN
cord-284409-xiyeceib	49	27	repertoires	repertoire	NNS
cord-284409-xiyeceib	49	28	and	and	CC
cord-284409-xiyeceib	49	29	demonstrated	demonstrate	VBD
cord-284409-xiyeceib	49	30	the	the	DT
cord-284409-xiyeceib	49	31	implications	implication	NNS
cord-284409-xiyeceib	49	32	of	of	IN
cord-284409-xiyeceib	49	33	our	-PRON-	PRP$
cord-284409-xiyeceib	49	34	antibody	antibody	NN
cord-284409-xiyeceib	49	35	germline	germline	NN
cord-284409-xiyeceib	49	36	/	/	SYM
cord-284409-xiyeceib	49	37	maturation	maturation	NN
cord-284409-xiyeceib	49	38	hypothesis	hypothesis	NN
cord-284409-xiyeceib	49	39	for	for	IN
cord-284409-xiyeceib	49	40	finding	find	VBG
cord-284409-xiyeceib	49	41	germline	germline	NN
cord-284409-xiyeceib	49	42	-	-	HYPH
cord-284409-xiyeceib	49	43	like	like	JJ
cord-284409-xiyeceib	49	44	precursors	precursor	NNS
cord-284409-xiyeceib	49	45	,	,	,
cord-284409-xiyeceib	49	46	intermediates	intermediate	NNS
cord-284409-xiyeceib	49	47	as	as	RB
cord-284409-xiyeceib	49	48	well	well	RB
cord-284409-xiyeceib	49	49	as	as	IN
cord-284409-xiyeceib	49	50	for	for	IN
cord-284409-xiyeceib	49	51	designing	design	VBG
cord-284409-xiyeceib	49	52	immunogens	immunogen	NNS
cord-284409-xiyeceib	49	53	that	that	WDT
cord-284409-xiyeceib	49	54	could	could	MD
cord-284409-xiyeceib	49	55	potentially	potentially	RB
cord-284409-xiyeceib	49	56	bind	bind	VB
cord-284409-xiyeceib	49	57	to	to	IN
cord-284409-xiyeceib	49	58	such	such	JJ
cord-284409-xiyeceib	49	59	bnAb	bnab	NN
cord-284409-xiyeceib	49	60	intermediates	intermediate	NNS
cord-284409-xiyeceib	49	61	.	.	.
cord-284409-xiyeceib	50	1	In	in	IN
cord-284409-xiyeceib	50	2	this	this	DT
cord-284409-xiyeceib	50	3	report	report	NN
cord-284409-xiyeceib	50	4	,	,	,
cord-284409-xiyeceib	50	5	we	-PRON-	PRP
cord-284409-xiyeceib	50	6	discuss	discuss	VBP
cord-284409-xiyeceib	50	7	the	the	DT
cord-284409-xiyeceib	50	8	recent	recent	JJ
cord-284409-xiyeceib	50	9	advancements	advancement	NNS
cord-284409-xiyeceib	50	10	in	in	IN
cord-284409-xiyeceib	50	11	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	50	12	vaccine	vaccine	NN
cord-284409-xiyeceib	50	13	research	research	NN
cord-284409-xiyeceib	50	14	in	in	IN
cord-284409-xiyeceib	50	15	the	the	DT
cord-284409-xiyeceib	50	16	context	context	NN
cord-284409-xiyeceib	50	17	of	of	IN
cord-284409-xiyeceib	50	18	the	the	DT
cord-284409-xiyeceib	50	19	antibody	antibody	NN
cord-284409-xiyeceib	50	20	germline	germline	NN
cord-284409-xiyeceib	50	21	/	/	SYM
cord-284409-xiyeceib	50	22	maturation	maturation	NN
cord-284409-xiyeceib	50	23	hypothesis	hypothesis	NN
cord-284409-xiyeceib	50	24	,	,	,
cord-284409-xiyeceib	50	25	and	and	CC
cord-284409-xiyeceib	50	26	highlight	highlight	VB
cord-284409-xiyeceib	50	27	critical	critical	JJ
cord-284409-xiyeceib	50	28	factors	factor	NNS
cord-284409-xiyeceib	50	29	to	to	TO
cord-284409-xiyeceib	50	30	be	be	VB
cord-284409-xiyeceib	50	31	considered	consider	VBN
cord-284409-xiyeceib	50	32	when	when	WRB
cord-284409-xiyeceib	50	33	exploring	explore	VBG
cord-284409-xiyeceib	50	34	germline	germline	NN
cord-284409-xiyeceib	50	35	-	-	HYPH
cord-284409-xiyeceib	50	36	like	like	JJ
cord-284409-xiyeceib	50	37	precursors	precursor	NNS
cord-284409-xiyeceib	50	38	and	and	CC
cord-284409-xiyeceib	50	39	intermediates	intermediate	NNS
cord-284409-xiyeceib	50	40	of	of	IN
cord-284409-xiyeceib	50	41	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	50	42	.	.	.
cord-284409-xiyeceib	51	1	We	-PRON-	PRP
cord-284409-xiyeceib	51	2	also	also	RB
cord-284409-xiyeceib	51	3	report	report	VBP
cord-284409-xiyeceib	51	4	for	for	IN
cord-284409-xiyeceib	51	5	the	the	DT
cord-284409-xiyeceib	51	6	first	first	JJ
cord-284409-xiyeceib	51	7	time	time	NN
cord-284409-xiyeceib	51	8	using	use	VBG
cord-284409-xiyeceib	51	9	454	454	CD
cord-284409-xiyeceib	51	10	sequencing	sequencing	NN
cord-284409-xiyeceib	51	11	data	datum	NNS
cord-284409-xiyeceib	51	12	analysis	analysis	NN
cord-284409-xiyeceib	51	13	of	of	IN
cord-284409-xiyeceib	51	14	a	a	DT
cord-284409-xiyeceib	51	15	human	human	JJ
cord-284409-xiyeceib	51	16	cord	cord	NN
cord-284409-xiyeceib	51	17	blood	blood	NN
cord-284409-xiyeceib	51	18	IgM	IgM	NNP
cord-284409-xiyeceib	51	19	library	library	NNP
cord-284409-xiyeceib	51	20	to	to	TO
cord-284409-xiyeceib	51	21	identify	identify	VB
cord-284409-xiyeceib	51	22	putative	putative	JJ
cord-284409-xiyeceib	51	23	germline	germline	JJ
cord-284409-xiyeceib	51	24	precursors	precursor	NNS
cord-284409-xiyeceib	51	25	of	of	IN
cord-284409-xiyeceib	51	26	the	the	DT
cord-284409-xiyeceib	51	27	heavy	heavy	JJ
cord-284409-xiyeceib	51	28	and	and	CC
cord-284409-xiyeceib	51	29	light	light	JJ
cord-284409-xiyeceib	51	30	chains	chain	NNS
cord-284409-xiyeceib	51	31	of	of	IN
cord-284409-xiyeceib	51	32	VRC01-like	VRC01-like	NNP
cord-284409-xiyeceib	51	33	antibodies	antibody	NNS
cord-284409-xiyeceib	51	34	.	.	.
cord-284409-xiyeceib	52	1	These	these	DT
cord-284409-xiyeceib	52	2	naturally	naturally	RB
cord-284409-xiyeceib	52	3	occurring	occur	VBG
cord-284409-xiyeceib	52	4	cord	cord	NN
cord-284409-xiyeceib	52	5	blood	blood	NN
cord-284409-xiyeceib	52	6	-	-	HYPH
cord-284409-xiyeceib	52	7	derived	derive	VBN
cord-284409-xiyeceib	52	8	VRC01-like	VRC01-like	''
cord-284409-xiyeceib	52	9	heavy	heavy	JJ
cord-284409-xiyeceib	52	10	and	and	CC
cord-284409-xiyeceib	52	11	light	light	JJ
cord-284409-xiyeceib	52	12	chains	chain	NNS
cord-284409-xiyeceib	52	13	may	may	MD
cord-284409-xiyeceib	52	14	be	be	VB
cord-284409-xiyeceib	52	15	useful	useful	JJ
cord-284409-xiyeceib	52	16	as	as	IN
cord-284409-xiyeceib	52	17	putative	putative	JJ
cord-284409-xiyeceib	52	18	templates	template	NNS
cord-284409-xiyeceib	52	19	for	for	IN
cord-284409-xiyeceib	52	20	designing	design	VBG
cord-284409-xiyeceib	52	21	novel	novel	JJ
cord-284409-xiyeceib	52	22	vaccine	vaccine	NN
cord-284409-xiyeceib	52	23	immunogens	immunogen	NNS
cord-284409-xiyeceib	52	24	that	that	WDT
cord-284409-xiyeceib	52	25	can	can	MD
cord-284409-xiyeceib	52	26	lead	lead	VB
cord-284409-xiyeceib	52	27	to	to	IN
cord-284409-xiyeceib	52	28	the	the	DT
cord-284409-xiyeceib	52	29	elicitation	elicitation	NN
cord-284409-xiyeceib	52	30	of	of	IN
cord-284409-xiyeceib	52	31	VRC01-like	VRC01-like	NNP
cord-284409-xiyeceib	52	32	antibodies	antibody	NNS
cord-284409-xiyeceib	52	33	and	and	CC
cord-284409-xiyeceib	52	34	for	for	IN
cord-284409-xiyeceib	52	35	understanding	understand	VBG
cord-284409-xiyeceib	52	36	the	the	DT
cord-284409-xiyeceib	52	37	maturation	maturation	NN
cord-284409-xiyeceib	52	38	pathways	pathway	NNS
cord-284409-xiyeceib	52	39	of	of	IN
cord-284409-xiyeceib	52	40	this	this	DT
cord-284409-xiyeceib	52	41	bnAb	bnab	NN
cord-284409-xiyeceib	52	42	.	.	.
cord-284409-xiyeceib	53	1	Still	still	RB
cord-284409-xiyeceib	53	2	there	there	EX
cord-284409-xiyeceib	53	3	are	be	VBP
cord-284409-xiyeceib	53	4	major	major	JJ
cord-284409-xiyeceib	53	5	challenges	challenge	NNS
cord-284409-xiyeceib	53	6	to	to	TO
cord-284409-xiyeceib	53	7	be	be	VB
cord-284409-xiyeceib	53	8	overcome	overcome	VBN
cord-284409-xiyeceib	53	9	.	.	.
cord-284409-xiyeceib	54	1	New	new	JJ
cord-284409-xiyeceib	54	2	empirical	empirical	JJ
cord-284409-xiyeceib	54	3	and	and	CC
cord-284409-xiyeceib	54	4	semiempirical	semiempirical	JJ
cord-284409-xiyeceib	54	5	approaches	approach	NNS
cord-284409-xiyeceib	54	6	could	could	MD
cord-284409-xiyeceib	54	7	be	be	VB
cord-284409-xiyeceib	54	8	successful	successful	JJ
cord-284409-xiyeceib	54	9	;	;	:
cord-284409-xiyeceib	54	10	recently	recently	RB
cord-284409-xiyeceib	54	11	,	,	,
cord-284409-xiyeceib	54	12	new	new	JJ
cord-284409-xiyeceib	54	13	paradigms	paradigm	NNS
cord-284409-xiyeceib	54	14	were	be	VBD
cord-284409-xiyeceib	54	15	discussed	discuss	VBN
cord-284409-xiyeceib	54	16	that	that	WDT
cord-284409-xiyeceib	54	17	could	could	MD
cord-284409-xiyeceib	54	18	better	well	RBR
cord-284409-xiyeceib	54	19	fit	fit	VB
cord-284409-xiyeceib	54	20	our	-PRON-	PRP$
cord-284409-xiyeceib	54	21	increased	increased	JJ
cord-284409-xiyeceib	54	22	knowledge	knowledge	NN
cord-284409-xiyeceib	54	23	of	of	IN
cord-284409-xiyeceib	54	24	HIV	HIV	NNP
cord-284409-xiyeceib	54	25	immunopathology	immunopathology	NN
cord-284409-xiyeceib	54	26	and	and	CC
cord-284409-xiyeceib	54	27	which	which	WDT
cord-284409-xiyeceib	54	28	could	could	MD
cord-284409-xiyeceib	54	29	possibly	possibly	RB
cord-284409-xiyeceib	54	30	be	be	VB
cord-284409-xiyeceib	54	31	more	more	RBR
cord-284409-xiyeceib	54	32	helpful	helpful	JJ
cord-284409-xiyeceib	54	33	in	in	IN
cord-284409-xiyeceib	54	34	guiding	guide	VBG
cord-284409-xiyeceib	54	35	future	future	JJ
cord-284409-xiyeceib	54	36	vaccine	vaccine	NN
cord-284409-xiyeceib	54	37	research	research	NN
cord-284409-xiyeceib	54	38	than	than	IN
cord-284409-xiyeceib	54	39	did	do	VBD
cord-284409-xiyeceib	54	40	past	past	JJ
cord-284409-xiyeceib	54	41	unsuccessful	unsuccessful	JJ
cord-284409-xiyeceib	54	42	approaches	approach	NNS
cord-284409-xiyeceib	54	43	(	(	-LRB-
cord-284409-xiyeceib	54	44	17	17	CD
cord-284409-xiyeceib	54	45	)	)	-RRB-
cord-284409-xiyeceib	54	46	.	.	.
cord-284409-xiyeceib	55	1	DNA	dna	NN
cord-284409-xiyeceib	55	2	isolation	isolation	NN
cord-284409-xiyeceib	55	3	,	,	,
cord-284409-xiyeceib	55	4	amplification	amplification	NN
cord-284409-xiyeceib	55	5	,	,	,
cord-284409-xiyeceib	55	6	and	and	CC
cord-284409-xiyeceib	55	7	454	454	CD
cord-284409-xiyeceib	55	8	sequencing	sequencing	NN
cord-284409-xiyeceib	55	9	of	of	IN
cord-284409-xiyeceib	55	10	the	the	DT
cord-284409-xiyeceib	55	11	human	human	JJ
cord-284409-xiyeceib	55	12	cord	cord	NN
cord-284409-xiyeceib	55	13	blood	blood	NNP
cord-284409-xiyeceib	55	14	IgM	IgM	NNP
cord-284409-xiyeceib	55	15	library	library	NNP
cord-284409-xiyeceib	55	16	were	be	VBD
cord-284409-xiyeceib	55	17	previously	previously	RB
cord-284409-xiyeceib	55	18	described	describe	VBN
cord-284409-xiyeceib	55	19	in	in	IN
cord-284409-xiyeceib	55	20	detail	detail	NN
cord-284409-xiyeceib	55	21	(	(	-LRB-
cord-284409-xiyeceib	55	22	18	18	CD
cord-284409-xiyeceib	55	23	,	,	,
cord-284409-xiyeceib	55	24	19	19	CD
cord-284409-xiyeceib	55	25	)	)	-RRB-
cord-284409-xiyeceib	55	26	.	.	.
cord-284409-xiyeceib	56	1	For	for	IN
cord-284409-xiyeceib	56	2	quality	quality	NN
cord-284409-xiyeceib	56	3	control	control	NN
cord-284409-xiyeceib	56	4	,	,	,
cord-284409-xiyeceib	56	5	we	-PRON-	PRP
cord-284409-xiyeceib	56	6	trimmed	trim	VBD
cord-284409-xiyeceib	56	7	the	the	DT
cord-284409-xiyeceib	56	8	454	454	CD
cord-284409-xiyeceib	56	9	sequence	sequence	NN
cord-284409-xiyeceib	56	10	reads	read	VBZ
cord-284409-xiyeceib	56	11	and	and	CC
cord-284409-xiyeceib	56	12	retained	retain	VBD
cord-284409-xiyeceib	56	13	only	only	RB
cord-284409-xiyeceib	56	14	sequences	sequence	NNS
cord-284409-xiyeceib	56	15	with	with	IN
cord-284409-xiyeceib	56	16	lengths	length	NNS
cord-284409-xiyeceib	56	17	of	of	IN
cord-284409-xiyeceib	56	18	more	more	JJR
cord-284409-xiyeceib	56	19	than	than	IN
cord-284409-xiyeceib	56	20	300	300	CD
cord-284409-xiyeceib	56	21	nucleotides	nucleotide	NNS
cord-284409-xiyeceib	56	22	,	,	,
cord-284409-xiyeceib	56	23	covering	cover	VBG
cord-284409-xiyeceib	56	24	the	the	DT
cord-284409-xiyeceib	56	25	entire	entire	JJ
cord-284409-xiyeceib	56	26	antibody	antibody	NN
cord-284409-xiyeceib	56	27	variable	variable	NN
cord-284409-xiyeceib	56	28	domains	domain	NNS
cord-284409-xiyeceib	56	29	consisting	consist	VBG
cord-284409-xiyeceib	56	30	of	of	IN
cord-284409-xiyeceib	56	31	all	all	DT
cord-284409-xiyeceib	56	32	three	three	CD
cord-284409-xiyeceib	56	33	complementarity	complementarity	NN
cord-284409-xiyeceib	56	34	determining	determine	VBG
cord-284409-xiyeceib	56	35	regions	region	NNS
cord-284409-xiyeceib	56	36	(	(	-LRB-
cord-284409-xiyeceib	56	37	CDRs	cdr	NNS
cord-284409-xiyeceib	56	38	)	)	-RRB-
cord-284409-xiyeceib	56	39	along	along	IN
cord-284409-xiyeceib	56	40	with	with	IN
cord-284409-xiyeceib	56	41	framework	framework	NN
cord-284409-xiyeceib	56	42	regions	region	NNS
cord-284409-xiyeceib	56	43	(	(	-LRB-
cord-284409-xiyeceib	56	44	FRs	FRs	NNP
cord-284409-xiyeceib	56	45	)	)	-RRB-
cord-284409-xiyeceib	56	46	.	.	.
cord-284409-xiyeceib	57	1	We	-PRON-	PRP
cord-284409-xiyeceib	57	2	used	use	VBD
cord-284409-xiyeceib	57	3	IMGT	IMGT	NNP
cord-284409-xiyeceib	57	4	/	/	SYM
cord-284409-xiyeceib	57	5	HighV	HighV	NNP
cord-284409-xiyeceib	57	6	-	-	HYPH
cord-284409-xiyeceib	57	7	QUEST	QUEST	NNP
cord-284409-xiyeceib	57	8	for	for	IN
cord-284409-xiyeceib	57	9	immunogenetic	immunogenetic	JJ
cord-284409-xiyeceib	57	10	and	and	CC
cord-284409-xiyeceib	57	11	statistical	statistical	JJ
cord-284409-xiyeceib	57	12	analyses	analysis	NNS
cord-284409-xiyeceib	57	13	(	(	-LRB-
cord-284409-xiyeceib	57	14	20	20	CD
cord-284409-xiyeceib	57	15	)	)	-RRB-
cord-284409-xiyeceib	57	16	.	.	.
cord-284409-xiyeceib	58	1	The	the	DT
cord-284409-xiyeceib	58	2	output	output	NN
cord-284409-xiyeceib	58	3	results	result	NNS
cord-284409-xiyeceib	58	4	from	from	IN
cord-284409-xiyeceib	58	5	the	the	DT
cord-284409-xiyeceib	58	6	IMGT	IMGT	NNP
cord-284409-xiyeceib	58	7	/	/	SYM
cord-284409-xiyeceib	58	8	HighV	HighV	NNP
cord-284409-xiyeceib	58	9	-	-	HYPH
cord-284409-xiyeceib	58	10	QUEST	quest	NN
cord-284409-xiyeceib	58	11	analysis	analysis	NN
cord-284409-xiyeceib	58	12	were	be	VBD
cord-284409-xiyeceib	58	13	stored	store	VBN
cord-284409-xiyeceib	58	14	in	in	IN
cord-284409-xiyeceib	58	15	a	a	DT
cord-284409-xiyeceib	58	16	local	local	JJ
cord-284409-xiyeceib	58	17	PostgreSQL	PostgreSQL	NNP
cord-284409-xiyeceib	58	18	database	database	NN
cord-284409-xiyeceib	58	19	,	,	,
cord-284409-xiyeceib	58	20	and	and	CC
cord-284409-xiyeceib	58	21	structured	structured	JJ
cord-284409-xiyeceib	58	22	query	query	NN
cord-284409-xiyeceib	58	23	language	language	NN
cord-284409-xiyeceib	58	24	(	(	-LRB-
cord-284409-xiyeceib	58	25	SQL	SQL	NNP
cord-284409-xiyeceib	58	26	)	)	-RRB-
cord-284409-xiyeceib	58	27	was	be	VBD
cord-284409-xiyeceib	58	28	used	use	VBN
cord-284409-xiyeceib	58	29	to	to	TO
cord-284409-xiyeceib	58	30	retrieve	retrieve	VB
cord-284409-xiyeceib	58	31	the	the	DT
cord-284409-xiyeceib	58	32	data	datum	NNS
cord-284409-xiyeceib	58	33	for	for	IN
cord-284409-xiyeceib	58	34	further	further	JJ
cord-284409-xiyeceib	58	35	analysis	analysis	NN
cord-284409-xiyeceib	58	36	.	.	.
cord-284409-xiyeceib	59	1	Statistical	statistical	JJ
cord-284409-xiyeceib	59	2	calculations	calculation	NNS
cord-284409-xiyeceib	59	3	were	be	VBD
cord-284409-xiyeceib	59	4	carried	carry	VBN
cord-284409-xiyeceib	59	5	out	out	RP
cord-284409-xiyeceib	59	6	using	use	VBG
cord-284409-xiyeceib	59	7	JMP10	jmp10	ADD
cord-284409-xiyeceib	60	1	®	®	,
cord-284409-xiyeceib	60	2	statistical	statistical	JJ
cord-284409-xiyeceib	60	3	software	software	NN
cord-284409-xiyeceib	60	4	(	(	-LRB-
cord-284409-xiyeceib	60	5	SAS	SAS	NNP
cord-284409-xiyeceib	60	6	Institute	Institute	NNP
cord-284409-xiyeceib	60	7	,	,	,
cord-284409-xiyeceib	60	8	Cary	Cary	NNP
cord-284409-xiyeceib	60	9	,	,	,
cord-284409-xiyeceib	60	10	NC	NC	NNP
cord-284409-xiyeceib	60	11	,	,	,
cord-284409-xiyeceib	60	12	USA	USA	NNP
cord-284409-xiyeceib	60	13	)	)	-RRB-
cord-284409-xiyeceib	60	14	.	.	.
cord-284409-xiyeceib	61	1	Antibody	antibody	NN
cord-284409-xiyeceib	61	2	sequences	sequence	NNS
cord-284409-xiyeceib	61	3	from	from	IN
cord-284409-xiyeceib	61	4	IGHV1	ighv1	NN
cord-284409-xiyeceib	61	5	-	-	SYM
cord-284409-xiyeceib	61	6	2	2	CD
cord-284409-xiyeceib	61	7	and	and	CC
cord-284409-xiyeceib	61	8	IGK3	IGK3	NNP
cord-284409-xiyeceib	61	9	-	-	HYPH
cord-284409-xiyeceib	61	10	11	11	CD
cord-284409-xiyeceib	61	11	lineages	lineage	NNS
cord-284409-xiyeceib	61	12	were	be	VBD
cord-284409-xiyeceib	61	13	retrieved	retrieve	VBN
cord-284409-xiyeceib	61	14	from	from	IN
cord-284409-xiyeceib	61	15	our	-PRON-	PRP$
cord-284409-xiyeceib	61	16	local	local	JJ
cord-284409-xiyeceib	61	17	antibodyome	antibodyome	NN
cord-284409-xiyeceib	61	18	database	database	NN
cord-284409-xiyeceib	61	19	consisting	consist	VBG
cord-284409-xiyeceib	61	20	of	of	IN
cord-284409-xiyeceib	61	21	immunogenetic	immunogenetic	JJ
cord-284409-xiyeceib	61	22	data	datum	NNS
cord-284409-xiyeceib	61	23	derived	derive	VBN
cord-284409-xiyeceib	61	24	from	from	IN
cord-284409-xiyeceib	61	25	454	454	CD
cord-284409-xiyeceib	61	26	sequencing	sequencing	NN
cord-284409-xiyeceib	61	27	of	of	IN
cord-284409-xiyeceib	61	28	the	the	DT
cord-284409-xiyeceib	61	29	human	human	JJ
cord-284409-xiyeceib	61	30	cord	cord	NN
cord-284409-xiyeceib	61	31	blood	blood	NNP
cord-284409-xiyeceib	61	32	IgM	IgM	NNP
cord-284409-xiyeceib	61	33	library	library	NNP
cord-284409-xiyeceib	61	34	using	use	VBG
cord-284409-xiyeceib	61	35	SQL	SQL	NNP
cord-284409-xiyeceib	61	36	statements	statement	NNS
cord-284409-xiyeceib	61	37	.	.	.
cord-284409-xiyeceib	62	1	Amino	amino	NN
cord-284409-xiyeceib	62	2	acid	acid	NN
cord-284409-xiyeceib	62	3	sequence	sequence	NN
cord-284409-xiyeceib	62	4	identities	identity	NNS
cord-284409-xiyeceib	62	5	between	between	IN
cord-284409-xiyeceib	62	6	each	each	DT
cord-284409-xiyeceib	62	7	of	of	IN
cord-284409-xiyeceib	62	8	the	the	DT
cord-284409-xiyeceib	62	9	selected	select	VBN
cord-284409-xiyeceib	62	10	lineage	lineage	NN
cord-284409-xiyeceib	62	11	sequences	sequence	NNS
cord-284409-xiyeceib	62	12	from	from	IN
cord-284409-xiyeceib	62	13	the	the	DT
cord-284409-xiyeceib	62	14	454	454	CD
cord-284409-xiyeceib	62	15	sequence	sequence	NN
cord-284409-xiyeceib	62	16	data	datum	NNS
cord-284409-xiyeceib	62	17	and	and	CC
cord-284409-xiyeceib	62	18	pertinent	pertinent	JJ
cord-284409-xiyeceib	62	19	germline	germline	JJ
cord-284409-xiyeceib	62	20	sequences	sequence	NNS
cord-284409-xiyeceib	62	21	were	be	VBD
cord-284409-xiyeceib	62	22	calculated	calculate	VBN
cord-284409-xiyeceib	62	23	based	base	VBN
cord-284409-xiyeceib	62	24	on	on	IN
cord-284409-xiyeceib	62	25	the	the	DT
cord-284409-xiyeceib	62	26	pairwise	pairwise	JJ
cord-284409-xiyeceib	62	27	alignment	alignment	NN
cord-284409-xiyeceib	62	28	using	use	VBG
cord-284409-xiyeceib	62	29	local	local	JJ
cord-284409-xiyeceib	62	30	BLAST	blast	NN
cord-284409-xiyeceib	62	31	as	as	IN
cord-284409-xiyeceib	62	32	implemented	implement	VBN
cord-284409-xiyeceib	62	33	in	in	IN
cord-284409-xiyeceib	62	34	BioEdit	BioEdit	NNP
cord-284409-xiyeceib	62	35	v7.0.9	v7.0.9	NNP
cord-284409-xiyeceib	62	36	(	(	-LRB-
cord-284409-xiyeceib	62	37	21	21	CD
cord-284409-xiyeceib	62	38	)	)	-RRB-
cord-284409-xiyeceib	62	39	.	.	.
cord-284409-xiyeceib	63	1	Phylogenetic	phylogenetic	JJ
cord-284409-xiyeceib	63	2	analysis	analysis	NN
cord-284409-xiyeceib	63	3	was	be	VBD
cord-284409-xiyeceib	63	4	carried	carry	VBN
cord-284409-xiyeceib	63	5	out	out	RP
cord-284409-xiyeceib	63	6	using	use	VBG
cord-284409-xiyeceib	63	7	the	the	DT
cord-284409-xiyeceib	63	8	Archaeopteryx	Archaeopteryx	NNP
cord-284409-xiyeceib	63	9	software	software	NN
cord-284409-xiyeceib	63	10	(	(	-LRB-
cord-284409-xiyeceib	63	11	22	22	CD
cord-284409-xiyeceib	63	12	)	)	-RRB-
cord-284409-xiyeceib	63	13	.	.	.
cord-284409-xiyeceib	64	1	Our	-PRON-	PRP$
cord-284409-xiyeceib	64	2	earlier	early	JJR
cord-284409-xiyeceib	64	3	observation	observation	NN
cord-284409-xiyeceib	64	4	of	of	IN
cord-284409-xiyeceib	64	5	the	the	DT
cord-284409-xiyeceib	64	6	extensive	extensive	JJ
cord-284409-xiyeceib	64	7	maturation	maturation	NN
cord-284409-xiyeceib	64	8	of	of	IN
cord-284409-xiyeceib	64	9	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	64	10	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	64	11	in	in	IN
cord-284409-xiyeceib	64	12	contrast	contrast	NN
cord-284409-xiyeceib	64	13	to	to	IN
cord-284409-xiyeceib	64	14	those	those	DT
cord-284409-xiyeceib	64	15	against	against	IN
cord-284409-xiyeceib	64	16	some	some	DT
cord-284409-xiyeceib	64	17	viruses	virus	NNS
cord-284409-xiyeceib	64	18	causing	cause	VBG
cord-284409-xiyeceib	64	19	acute	acute	JJ
cord-284409-xiyeceib	64	20	infections	infection	NNS
cord-284409-xiyeceib	64	21	led	lead	VBD
cord-284409-xiyeceib	64	22	to	to	IN
cord-284409-xiyeceib	64	23	the	the	DT
cord-284409-xiyeceib	64	24	antibody	antibody	NN
cord-284409-xiyeceib	64	25	germline	germline	NN
cord-284409-xiyeceib	64	26	/	/	SYM
cord-284409-xiyeceib	64	27	maturation	maturation	NN
cord-284409-xiyeceib	64	28	hypothesis	hypothesis	NN
cord-284409-xiyeceib	64	29	(	(	-LRB-
cord-284409-xiyeceib	64	30	9	9	CD
cord-284409-xiyeceib	64	31	-	-	SYM
cord-284409-xiyeceib	64	32	11	11	CD
cord-284409-xiyeceib	64	33	,	,	,
cord-284409-xiyeceib	64	34	13	13	CD
cord-284409-xiyeceib	64	35	,	,	,
cord-284409-xiyeceib	64	36	14	14	CD
cord-284409-xiyeceib	64	37	)	)	-RRB-
cord-284409-xiyeceib	64	38	.	.	.
cord-284409-xiyeceib	65	1	According	accord	VBG
cord-284409-xiyeceib	65	2	to	to	IN
cord-284409-xiyeceib	65	3	this	this	DT
cord-284409-xiyeceib	65	4	hypothesis	hypothesis	NN
cord-284409-xiyeceib	65	5	,	,	,
cord-284409-xiyeceib	65	6	it	-PRON-	PRP
cord-284409-xiyeceib	65	7	is	be	VBZ
cord-284409-xiyeceib	65	8	critical	critical	JJ
cord-284409-xiyeceib	65	9	to	to	TO
cord-284409-xiyeceib	65	10	identify	identify	VB
cord-284409-xiyeceib	65	11	immunogens	immunogen	NNS
cord-284409-xiyeceib	65	12	that	that	WDT
cord-284409-xiyeceib	65	13	would	would	MD
cord-284409-xiyeceib	65	14	bind	bind	VB
cord-284409-xiyeceib	65	15	to	to	IN
cord-284409-xiyeceib	65	16	germline	germline	JJ
cord-284409-xiyeceib	65	17	and/or	and/or	CC
cord-284409-xiyeceib	65	18	intermediate	intermediate	JJ
cord-284409-xiyeceib	65	19	antibodies	antibody	NNS
cord-284409-xiyeceib	65	20	of	of	IN
cord-284409-xiyeceib	65	21	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	65	22	,	,	,
cord-284409-xiyeceib	65	23	as	as	RB
cord-284409-xiyeceib	65	24	well	well	RB
cord-284409-xiyeceib	65	25	as	as	IN
cord-284409-xiyeceib	65	26	the	the	DT
cord-284409-xiyeceib	65	27	exploration	exploration	NN
cord-284409-xiyeceib	65	28	of	of	IN
cord-284409-xiyeceib	65	29	antibodyomes	antibodyomes	NNP
cord-284409-xiyeceib	65	30	could	could	MD
cord-284409-xiyeceib	65	31	be	be	VB
cord-284409-xiyeceib	65	32	useful	useful	JJ
cord-284409-xiyeceib	65	33	for	for	IN
cord-284409-xiyeceib	65	34	identifying	identify	VBG
cord-284409-xiyeceib	65	35	such	such	JJ
cord-284409-xiyeceib	65	36	immunogens	immunogen	NNS
cord-284409-xiyeceib	65	37	(	(	-LRB-
cord-284409-xiyeceib	65	38	14	14	CD
cord-284409-xiyeceib	65	39	)	)	-RRB-
cord-284409-xiyeceib	65	40	.	.	.
cord-284409-xiyeceib	66	1	Figure	figure	NN
cord-284409-xiyeceib	66	2	1	1	CD
cord-284409-xiyeceib	66	3	describes	describe	VBZ
cord-284409-xiyeceib	66	4	the	the	DT
cord-284409-xiyeceib	66	5	timeline	timeline	NN
cord-284409-xiyeceib	66	6	involving	involve	VBG
cord-284409-xiyeceib	66	7	some	some	DT
cord-284409-xiyeceib	66	8	of	of	IN
cord-284409-xiyeceib	66	9	the	the	DT
cord-284409-xiyeceib	66	10	key	key	JJ
cord-284409-xiyeceib	66	11	developments	development	NNS
cord-284409-xiyeceib	66	12	in	in	IN
cord-284409-xiyeceib	66	13	current	current	JJ
cord-284409-xiyeceib	66	14	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	66	15	vaccine	vaccine	NN
cord-284409-xiyeceib	66	16	research	research	NN
cord-284409-xiyeceib	66	17	focused	focus	VBD
cord-284409-xiyeceib	66	18	on	on	IN
cord-284409-xiyeceib	66	19	antibody	antibody	NN
cord-284409-xiyeceib	66	20	germline	germline	NN
cord-284409-xiyeceib	66	21	-	-	HYPH
cord-284409-xiyeceib	66	22	like	like	JJ
cord-284409-xiyeceib	66	23	intermediates	intermediate	NNS
cord-284409-xiyeceib	66	24	and	and	CC
cord-284409-xiyeceib	66	25	maturation	maturation	NN
cord-284409-xiyeceib	66	26	pathways	pathway	NNS
cord-284409-xiyeceib	66	27	of	of	IN
cord-284409-xiyeceib	66	28	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	66	29	.	.	.
cord-284409-xiyeceib	67	1	Major	major	JJ
cord-284409-xiyeceib	67	2	research	research	NN
cord-284409-xiyeceib	67	3	efforts	effort	NNS
cord-284409-xiyeceib	67	4	in	in	IN
cord-284409-xiyeceib	67	5	this	this	DT
cord-284409-xiyeceib	67	6	direction	direction	NN
cord-284409-xiyeceib	67	7	were	be	VBD
cord-284409-xiyeceib	67	8	spearheaded	spearhead	VBN
cord-284409-xiyeceib	67	9	by	by	IN
cord-284409-xiyeceib	68	1	deep	deep	JJ
cord-284409-xiyeceib	68	2	sequencing	sequencing	NN
cord-284409-xiyeceib	68	3	and	and	CC
cord-284409-xiyeceib	68	4	structural	structural	JJ
cord-284409-xiyeceib	68	5	biology	biology	NN
cord-284409-xiyeceib	68	6	studies	study	NNS
cord-284409-xiyeceib	68	7	of	of	IN
cord-284409-xiyeceib	68	8	VRC01-like	VRC01-like	NNP
cord-284409-xiyeceib	68	9	and	and	CC
cord-284409-xiyeceib	68	10	other	other	JJ
cord-284409-xiyeceib	68	11	CD4-binding	cd4-binding	NN
cord-284409-xiyeceib	68	12	site	site	NN
cord-284409-xiyeceib	68	13	(	(	-LRB-
cord-284409-xiyeceib	68	14	CD4b	CD4b	NNP
cord-284409-xiyeceib	68	15	)	)	-RRB-
cord-284409-xiyeceib	68	16	antibodies	antibody	NNS
cord-284409-xiyeceib	68	17	from	from	IN
cord-284409-xiyeceib	68	18	HIV-1-infected	hiv-1-infecte	VBN
cord-284409-xiyeceib	68	19	individuals	individual	NNS
cord-284409-xiyeceib	68	20	.	.	.
cord-284409-xiyeceib	69	1	These	these	DT
cord-284409-xiyeceib	69	2	studies	study	NNS
cord-284409-xiyeceib	69	3	delineated	delineate	VBD
cord-284409-xiyeceib	69	4	possible	possible	JJ
cord-284409-xiyeceib	69	5	maturation	maturation	NN
cord-284409-xiyeceib	69	6	pathways	pathway	NNS
cord-284409-xiyeceib	69	7	of	of	IN
cord-284409-xiyeceib	69	8	such	such	JJ
cord-284409-xiyeceib	69	9	antibodies	antibody	NNS
cord-284409-xiyeceib	69	10	with	with	IN
cord-284409-xiyeceib	69	11	high	high	JJ
cord-284409-xiyeceib	69	12	levels	level	NNS
cord-284409-xiyeceib	69	13	of	of	IN
cord-284409-xiyeceib	69	14	somatic	somatic	JJ
cord-284409-xiyeceib	69	15	mutations	mutation	NNS
cord-284409-xiyeceib	69	16	and	and	CC
cord-284409-xiyeceib	69	17	convergence	convergence	NN
cord-284409-xiyeceib	69	18	in	in	IN
cord-284409-xiyeceib	69	19	antibody	antibody	NN
cord-284409-xiyeceib	69	20	recognition	recognition	NN
cord-284409-xiyeceib	69	21	(	(	-LRB-
cord-284409-xiyeceib	69	22	23	23	CD
cord-284409-xiyeceib	69	23	,	,	,
cord-284409-xiyeceib	69	24	24	24	CD
cord-284409-xiyeceib	69	25	)	)	-RRB-
cord-284409-xiyeceib	69	26	.	.	.
cord-284409-xiyeceib	70	1	Both	both	DT
cord-284409-xiyeceib	70	2	studies	study	NNS
cord-284409-xiyeceib	70	3	revealed	reveal	VBD
cord-284409-xiyeceib	70	4	that	that	IN
cord-284409-xiyeceib	70	5	the	the	DT
cord-284409-xiyeceib	70	6	putative	putative	JJ
cord-284409-xiyeceib	70	7	germline	germline	JJ
cord-284409-xiyeceib	70	8	precursors	precursor	NNS
cord-284409-xiyeceib	70	9	of	of	IN
cord-284409-xiyeceib	70	10	these	these	DT
cord-284409-xiyeceib	70	11	antibodies	antibody	NNS
cord-284409-xiyeceib	70	12	had	have	VBD
cord-284409-xiyeceib	70	13	weak	weak	JJ
cord-284409-xiyeceib	70	14	or	or	CC
cord-284409-xiyeceib	70	15	no	no	DT
cord-284409-xiyeceib	70	16	apparent	apparent	JJ
cord-284409-xiyeceib	70	17	affinity	affinity	NN
cord-284409-xiyeceib	70	18	for	for	IN
cord-284409-xiyeceib	70	19	Env	Env	NNP
cord-284409-xiyeceib	70	20	,	,	,
cord-284409-xiyeceib	70	21	and	and	CC
cord-284409-xiyeceib	70	22	acquisition	acquisition	NN
cord-284409-xiyeceib	70	23	of	of	IN
cord-284409-xiyeceib	70	24	a	a	DT
cord-284409-xiyeceib	70	25	large	large	JJ
cord-284409-xiyeceib	70	26	number	number	NN
cord-284409-xiyeceib	70	27	of	of	IN
cord-284409-xiyeceib	70	28	somatic	somatic	JJ
cord-284409-xiyeceib	70	29	mutations	mutation	NNS
cord-284409-xiyeceib	70	30	were	be	VBD
cord-284409-xiyeceib	70	31	needed	need	VBN
cord-284409-xiyeceib	70	32	for	for	IN
cord-284409-xiyeceib	70	33	the	the	DT
cord-284409-xiyeceib	70	34	breadth	breadth	NN
cord-284409-xiyeceib	70	35	and	and	CC
cord-284409-xiyeceib	70	36	potency	potency	NN
cord-284409-xiyeceib	70	37	of	of	IN
cord-284409-xiyeceib	70	38	these	these	DT
cord-284409-xiyeceib	70	39	antibodies	antibody	NNS
cord-284409-xiyeceib	70	40	.	.	.
cord-284409-xiyeceib	71	1	These	these	DT
cord-284409-xiyeceib	71	2	studies	study	NNS
cord-284409-xiyeceib	71	3	also	also	RB
cord-284409-xiyeceib	71	4	explored	explore	VBD
cord-284409-xiyeceib	71	5	antibody	antibody	NN
cord-284409-xiyeceib	71	6	diversity	diversity	NN
cord-284409-xiyeceib	71	7	and	and	CC
cord-284409-xiyeceib	71	8	found	find	VBD
cord-284409-xiyeceib	71	9	many	many	JJ
cord-284409-xiyeceib	71	10	intermediates	intermediate	NNS
cord-284409-xiyeceib	71	11	of	of	IN
cord-284409-xiyeceib	71	12	similar	similar	JJ
cord-284409-xiyeceib	71	13	lineages	lineage	NNS
cord-284409-xiyeceib	71	14	of	of	IN
cord-284409-xiyeceib	71	15	the	the	DT
cord-284409-xiyeceib	71	16	heavy	heavy	JJ
cord-284409-xiyeceib	71	17	chain	chain	NN
cord-284409-xiyeceib	71	18	genes	gene	NNS
cord-284409-xiyeceib	71	19	from	from	IN
cord-284409-xiyeceib	71	20	the	the	DT
cord-284409-xiyeceib	71	21	two	two	CD
cord-284409-xiyeceib	71	22	IGHV	IGHV	NNP
cord-284409-xiyeceib	71	23	families	family	NNS
cord-284409-xiyeceib	71	24	VH1	VH1	NNP
cord-284409-xiyeceib	71	25	-	-	HYPH
cord-284409-xiyeceib	71	26	2	2	NNP
cord-284409-xiyeceib	71	27	and	and	CC
cord-284409-xiyeceib	71	28	VH1	VH1	NNP
cord-284409-xiyeceib	71	29	-	-	:
cord-284409-xiyeceib	71	30	46	46	CD
cord-284409-xiyeceib	71	31	that	that	WDT
cord-284409-xiyeceib	71	32	paired	pair	VBN
cord-284409-xiyeceib	71	33	with	with	IN
cord-284409-xiyeceib	71	34	different	different	JJ
cord-284409-xiyeceib	71	35	light	light	JJ
cord-284409-xiyeceib	71	36	chain	chain	NN
cord-284409-xiyeceib	71	37	genes	gene	NNS
cord-284409-xiyeceib	71	38	.	.	.
cord-284409-xiyeceib	72	1	Thus	thus	RB
cord-284409-xiyeceib	72	2	,	,	,
cord-284409-xiyeceib	72	3	analysis	analysis	NN
cord-284409-xiyeceib	72	4	of	of	IN
cord-284409-xiyeceib	72	5	the	the	DT
cord-284409-xiyeceib	72	6	VRC01-related	VRC01-related	NNP
cord-284409-xiyeceib	72	7	antibodyome	antibodyome	NNP
cord-284409-xiyeceib	72	8	from	from	IN
cord-284409-xiyeceib	72	9	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	72	10	infected	infect	VBD
cord-284409-xiyeceib	72	11	patients	patient	NNS
cord-284409-xiyeceib	72	12	revealed	reveal	VBD
cord-284409-xiyeceib	72	13	B	b	NN
cord-284409-xiyeceib	72	14	cell	cell	NN
cord-284409-xiyeceib	72	15	maturation	maturation	NN
cord-284409-xiyeceib	72	16	pathways	pathway	NNS
cord-284409-xiyeceib	72	17	that	that	WDT
cord-284409-xiyeceib	72	18	may	may	MD
cord-284409-xiyeceib	72	19	help	help	VB
cord-284409-xiyeceib	72	20	guide	guide	VB
cord-284409-xiyeceib	72	21	the	the	DT
cord-284409-xiyeceib	72	22	vaccine	vaccine	NN
cord-284409-xiyeceib	72	23	-	-	HYPH
cord-284409-xiyeceib	72	24	induced	induce	VBN
cord-284409-xiyeceib	72	25	elicitation	elicitation	NN
cord-284409-xiyeceib	72	26	of	of	IN
cord-284409-xiyeceib	72	27	such	such	JJ
cord-284409-xiyeceib	72	28	antibodies	antibody	NNS
cord-284409-xiyeceib	72	29	.	.	.
cord-284409-xiyeceib	73	1	However	however	RB
cord-284409-xiyeceib	73	2	,	,	,
cord-284409-xiyeceib	73	3	if	if	IN
cord-284409-xiyeceib	73	4	we	-PRON-	PRP
cord-284409-xiyeceib	73	5	could	could	MD
cord-284409-xiyeceib	73	6	find	find	VB
cord-284409-xiyeceib	73	7	germline	germline	NN
cord-284409-xiyeceib	73	8	-	-	HYPH
cord-284409-xiyeceib	73	9	like	like	JJ
cord-284409-xiyeceib	73	10	intermediates	intermediate	NNS
cord-284409-xiyeceib	73	11	of	of	IN
cord-284409-xiyeceib	73	12	such	such	JJ
cord-284409-xiyeceib	73	13	bnAbs	bnabs	NN
cord-284409-xiyeceib	73	14	from	from	IN
cord-284409-xiyeceib	73	15	a	a	DT
cord-284409-xiyeceib	73	16	naïve	naïve	JJ
cord-284409-xiyeceib	73	17	antibody	antibody	NN
cord-284409-xiyeceib	73	18	repertoire	repertoire	NN
cord-284409-xiyeceib	73	19	,	,	,
cord-284409-xiyeceib	73	20	then	then	RB
cord-284409-xiyeceib	73	21	www.frontiersin.org	www.frontiersin.org	IN
cord-284409-xiyeceib	73	22	potential	potential	JJ
cord-284409-xiyeceib	73	23	vaccine	vaccine	NN
cord-284409-xiyeceib	73	24	immunogens	immunogen	NNS
cord-284409-xiyeceib	73	25	developed	develop	VBD
cord-284409-xiyeceib	73	26	based	base	VBN
cord-284409-xiyeceib	73	27	on	on	IN
cord-284409-xiyeceib	73	28	those	those	DT
cord-284409-xiyeceib	73	29	templates	template	NNS
cord-284409-xiyeceib	73	30	would	would	MD
cord-284409-xiyeceib	73	31	stimulate	stimulate	VB
cord-284409-xiyeceib	73	32	an	an	DT
cord-284409-xiyeceib	73	33	adequate	adequate	JJ
cord-284409-xiyeceib	73	34	B	b	NN
cord-284409-xiyeceib	73	35	cell	cell	NN
cord-284409-xiyeceib	73	36	immune	immune	JJ
cord-284409-xiyeceib	73	37	response	response	NN
cord-284409-xiyeceib	73	38	in	in	IN
cord-284409-xiyeceib	73	39	healthy	healthy	JJ
cord-284409-xiyeceib	73	40	humans	human	NNS
cord-284409-xiyeceib	73	41	.	.	.
cord-284409-xiyeceib	74	1	To	to	IN
cord-284409-xiyeceib	74	2	this	this	DT
cord-284409-xiyeceib	74	3	end	end	NN
cord-284409-xiyeceib	74	4	,	,	,
cord-284409-xiyeceib	74	5	we	-PRON-	PRP
cord-284409-xiyeceib	74	6	identified	identify	VBD
cord-284409-xiyeceib	74	7	VRC01-like	vrc01-like	IN
cord-284409-xiyeceib	74	8	intermediate	intermediate	JJ
cord-284409-xiyeceib	74	9	antibodies	antibody	NNS
cord-284409-xiyeceib	74	10	from	from	IN
cord-284409-xiyeceib	74	11	a	a	DT
cord-284409-xiyeceib	74	12	naïve	naïve	JJ
cord-284409-xiyeceib	74	13	antibody	antibody	NN
cord-284409-xiyeceib	74	14	library	library	NN
cord-284409-xiyeceib	74	15	of	of	IN
cord-284409-xiyeceib	74	16	human	human	JJ
cord-284409-xiyeceib	74	17	cord	cord	NN
cord-284409-xiyeceib	74	18	blood	blood	NN
cord-284409-xiyeceib	74	19	,	,	,
cord-284409-xiyeceib	74	20	which	which	WDT
cord-284409-xiyeceib	74	21	is	be	VBZ
cord-284409-xiyeceib	74	22	presented	present	VBN
cord-284409-xiyeceib	74	23	later	later	RB
cord-284409-xiyeceib	74	24	in	in	IN
cord-284409-xiyeceib	74	25	the	the	DT
cord-284409-xiyeceib	74	26	text	text	NN
cord-284409-xiyeceib	74	27	.	.	.
cord-284409-xiyeceib	75	1	We	-PRON-	PRP
cord-284409-xiyeceib	75	2	previously	previously	RB
cord-284409-xiyeceib	75	3	analyzed	analyze	VBD
cord-284409-xiyeceib	75	4	the	the	DT
cord-284409-xiyeceib	75	5	IgM	IgM	NNP
cord-284409-xiyeceib	75	6	repertoires	repertoire	NNS
cord-284409-xiyeceib	75	7	of	of	IN
cord-284409-xiyeceib	75	8	healthy	healthy	JJ
cord-284409-xiyeceib	75	9	individuals	individual	NNS
cord-284409-xiyeceib	75	10	and	and	CC
cord-284409-xiyeceib	75	11	identified	identify	VBD
cord-284409-xiyeceib	75	12	several	several	JJ
cord-284409-xiyeceib	75	13	intermediates	intermediate	NNS
cord-284409-xiyeceib	75	14	of	of	IN
cord-284409-xiyeceib	75	15	b12	b12	NN
cord-284409-xiyeceib	75	16	from	from	IN
cord-284409-xiyeceib	75	17	the	the	DT
cord-284409-xiyeceib	75	18	VH1	VH1	NNP
cord-284409-xiyeceib	75	19	-	-	HYPH
cord-284409-xiyeceib	75	20	3	3	CD
cord-284409-xiyeceib	75	21	gene	gene	NN
cord-284409-xiyeceib	75	22	family	family	NN
cord-284409-xiyeceib	75	23	(	(	-LRB-
cord-284409-xiyeceib	75	24	15	15	CD
cord-284409-xiyeceib	75	25	)	)	-RRB-
cord-284409-xiyeceib	75	26	.	.	.
cord-284409-xiyeceib	76	1	Sequence	sequence	NN
cord-284409-xiyeceib	76	2	analysis	analysis	NN
cord-284409-xiyeceib	76	3	of	of	IN
cord-284409-xiyeceib	76	4	28,925	28,925	CD
cord-284409-xiyeceib	76	5	unique	unique	JJ
cord-284409-xiyeceib	76	6	sequences	sequence	NNS
cord-284409-xiyeceib	76	7	from	from	IN
cord-284409-xiyeceib	76	8	the	the	DT
cord-284409-xiyeceib	76	9	IgM	IgM	NNP
cord-284409-xiyeceib	76	10	repertoires	repertoire	NNS
cord-284409-xiyeceib	76	11	revealed	reveal	VBD
cord-284409-xiyeceib	76	12	a	a	DT
cord-284409-xiyeceib	76	13	CDRH3	cdrh3	NN
cord-284409-xiyeceib	76	14	with	with	IN
cord-284409-xiyeceib	76	15	a	a	DT
cord-284409-xiyeceib	76	16	length	length	NN
cord-284409-xiyeceib	76	17	(	(	-LRB-
cord-284409-xiyeceib	76	18	20	20	CD
cord-284409-xiyeceib	76	19	amino	amino	JJ
cord-284409-xiyeceib	76	20	acids	acid	NNS
cord-284409-xiyeceib	76	21	)	)	-RRB-
cord-284409-xiyeceib	76	22	and	and	CC
cord-284409-xiyeceib	76	23	sequence	sequence	VB
cord-284409-xiyeceib	76	24	similar	similar	JJ
cord-284409-xiyeceib	76	25	(	(	-LRB-
cord-284409-xiyeceib	76	26	50	50	CD
cord-284409-xiyeceib	76	27	%	%	NN
cord-284409-xiyeceib	76	28	)	)	-RRB-
cord-284409-xiyeceib	76	29	to	to	IN
cord-284409-xiyeceib	76	30	that	that	DT
cord-284409-xiyeceib	76	31	of	of	IN
cord-284409-xiyeceib	76	32	the	the	DT
cord-284409-xiyeceib	76	33	b12	b12	NN
cord-284409-xiyeceib	76	34	CDRH3	cdrh3	NN
cord-284409-xiyeceib	76	35	,	,	,
cord-284409-xiyeceib	76	36	but	but	CC
cord-284409-xiyeceib	76	37	the	the	DT
cord-284409-xiyeceib	76	38	V	v	NN
cord-284409-xiyeceib	76	39	gene	gene	NN
cord-284409-xiyeceib	76	40	associated	associate	VBN
cord-284409-xiyeceib	76	41	with	with	IN
cord-284409-xiyeceib	76	42	that	that	DT
cord-284409-xiyeceib	76	43	CDRH3	cdrh3	NN
cord-284409-xiyeceib	76	44	was	be	VBD
cord-284409-xiyeceib	76	45	found	find	VBN
cord-284409-xiyeceib	76	46	to	to	TO
cord-284409-xiyeceib	76	47	be	be	VB
cord-284409-xiyeceib	76	48	HV4-b	HV4-b	NNP
cord-284409-xiyeceib	76	49	(	(	-LRB-
cord-284409-xiyeceib	76	50	15	15	CD
cord-284409-xiyeceib	76	51	)	)	-RRB-
cord-284409-xiyeceib	76	52	.	.	.
cord-284409-xiyeceib	77	1	This	this	DT
cord-284409-xiyeceib	77	2	finding	finding	NN
cord-284409-xiyeceib	77	3	indicates	indicate	VBZ
cord-284409-xiyeceib	77	4	that	that	IN
cord-284409-xiyeceib	77	5	long	long	JJ
cord-284409-xiyeceib	77	6	CDRH3s	cdrh3s	NN
cord-284409-xiyeceib	77	7	may	may	MD
cord-284409-xiyeceib	77	8	not	not	RB
cord-284409-xiyeceib	77	9	be	be	VB
cord-284409-xiyeceib	77	10	a	a	DT
cord-284409-xiyeceib	77	11	limiting	limit	VBG
cord-284409-xiyeceib	77	12	factor	factor	NN
cord-284409-xiyeceib	77	13	for	for	IN
cord-284409-xiyeceib	77	14	the	the	DT
cord-284409-xiyeceib	77	15	development	development	NN
cord-284409-xiyeceib	77	16	of	of	IN
cord-284409-xiyeceib	77	17	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	77	18	(	(	-LRB-
cord-284409-xiyeceib	77	19	25	25	CD
cord-284409-xiyeceib	77	20	)	)	-RRB-
cord-284409-xiyeceib	77	21	although	although	IN
cord-284409-xiyeceib	77	22	long	long	JJ
cord-284409-xiyeceib	77	23	CDRH3	cdrh3	NN
cord-284409-xiyeceib	77	24	motifs	motif	NNS
cord-284409-xiyeceib	77	25	with	with	IN
cord-284409-xiyeceib	77	26	certain	certain	JJ
cord-284409-xiyeceib	77	27	amino	amino	NN
cord-284409-xiyeceib	77	28	acid	acid	NN
cord-284409-xiyeceib	77	29	preferences	preference	NNS
cord-284409-xiyeceib	77	30	and/or	and/or	CC
cord-284409-xiyeceib	77	31	associations	association	NNS
cord-284409-xiyeceib	77	32	with	with	IN
cord-284409-xiyeceib	77	33	particular	particular	JJ
cord-284409-xiyeceib	77	34	heavy	heavy	JJ
cord-284409-xiyeceib	77	35	or	or	CC
cord-284409-xiyeceib	77	36	light	light	JJ
cord-284409-xiyeceib	77	37	chain	chain	NN
cord-284409-xiyeceib	77	38	families	family	NNS
cord-284409-xiyeceib	77	39	favoring	favor	VBG
cord-284409-xiyeceib	77	40	polyreactivity	polyreactivity	NN
cord-284409-xiyeceib	77	41	may	may	MD
cord-284409-xiyeceib	77	42	not	not	RB
cord-284409-xiyeceib	77	43	be	be	VB
cord-284409-xiyeceib	77	44	undermined	undermine	VBN
cord-284409-xiyeceib	77	45	.	.	.
cord-284409-xiyeceib	78	1	Stamatatos	stamatatos	NN
cord-284409-xiyeceib	78	2	and	and	CC
cord-284409-xiyeceib	78	3	coworkers	coworker	NNS
cord-284409-xiyeceib	78	4	have	have	VBP
cord-284409-xiyeceib	78	5	conducted	conduct	VBN
cord-284409-xiyeceib	78	6	experiments	experiment	NNS
cord-284409-xiyeceib	78	7	screening	screen	VBG
cord-284409-xiyeceib	78	8	a	a	DT
cord-284409-xiyeceib	78	9	large	large	JJ
cord-284409-xiyeceib	78	10	panel	panel	NN
cord-284409-xiyeceib	78	11	of	of	IN
cord-284409-xiyeceib	78	12	recombinant	recombinant	JJ
cord-284409-xiyeceib	78	13	Envs	Envs	NNP
cord-284409-xiyeceib	78	14	for	for	IN
cord-284409-xiyeceib	78	15	binding	bind	VBG
cord-284409-xiyeceib	78	16	to	to	IN
cord-284409-xiyeceib	78	17	the	the	DT
cord-284409-xiyeceib	78	18	germline	germline	JJ
cord-284409-xiyeceib	78	19	predecessors	predecessor	NNS
cord-284409-xiyeceib	78	20	of	of	IN
cord-284409-xiyeceib	78	21	b12	b12	NN
cord-284409-xiyeceib	78	22	,	,	,
cord-284409-xiyeceib	78	23	NIH45	NIH45	NNP
cord-284409-xiyeceib	78	24	-	-	HYPH
cord-284409-xiyeceib	78	25	46	46	CD
cord-284409-xiyeceib	78	26	,	,	,
cord-284409-xiyeceib	78	27	and	and	CC
cord-284409-xiyeceib	78	28	3BNC60	3bnc60	CD
cord-284409-xiyeceib	78	29	to	to	TO
cord-284409-xiyeceib	78	30	test	test	VB
cord-284409-xiyeceib	78	31	how	how	WRB
cord-284409-xiyeceib	78	32	Env	Env	NNP
cord-284409-xiyeceib	78	33	immunogens	immunogen	NNS
cord-284409-xiyeceib	78	34	interact	interact	VBP
cord-284409-xiyeceib	78	35	with	with	IN
cord-284409-xiyeceib	78	36	the	the	DT
cord-284409-xiyeceib	78	37	predicted	predict	VBN
cord-284409-xiyeceib	78	38	germline	germline	JJ
cord-284409-xiyeceib	78	39	versions	version	NNS
cord-284409-xiyeceib	78	40	of	of	IN
cord-284409-xiyeceib	78	41	known	know	VBN
cord-284409-xiyeceib	78	42	bnAbs	bnabs	NN
cord-284409-xiyeceib	78	43	(	(	-LRB-
cord-284409-xiyeceib	78	44	26	26	CD
cord-284409-xiyeceib	78	45	)	)	-RRB-
cord-284409-xiyeceib	78	46	.	.	.
cord-284409-xiyeceib	79	1	They	-PRON-	PRP
cord-284409-xiyeceib	79	2	found	find	VBD
cord-284409-xiyeceib	79	3	that	that	IN
cord-284409-xiyeceib	79	4	the	the	DT
cord-284409-xiyeceib	79	5	mature	mature	JJ
cord-284409-xiyeceib	79	6	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	79	7	reacted	react	VBD
cord-284409-xiyeceib	79	8	with	with	IN
cord-284409-xiyeceib	79	9	diverse	diverse	JJ
cord-284409-xiyeceib	79	10	Envs	Envs	NNP
cord-284409-xiyeceib	79	11	but	but	CC
cord-284409-xiyeceib	79	12	the	the	DT
cord-284409-xiyeceib	79	13	corresponding	corresponding	JJ
cord-284409-xiyeceib	79	14	germline	germline	NN
cord-284409-xiyeceib	79	15	antibodies	antibody	NNS
cord-284409-xiyeceib	79	16	did	do	VBD
cord-284409-xiyeceib	79	17	not	not	RB
cord-284409-xiyeceib	79	18	.	.	.
cord-284409-xiyeceib	80	1	They	-PRON-	PRP
cord-284409-xiyeceib	80	2	examined	examine	VBD
cord-284409-xiyeceib	80	3	in	in	IN
cord-284409-xiyeceib	80	4	detail	detail	NN
cord-284409-xiyeceib	80	5	the	the	DT
cord-284409-xiyeceib	80	6	germline	germline	JJ
cord-284409-xiyeceib	80	7	b12	b12	NN
cord-284409-xiyeceib	80	8	and	and	CC
cord-284409-xiyeceib	80	9	its	-PRON-	PRP$
cord-284409-xiyeceib	80	10	chimeric	chimeric	JJ
cord-284409-xiyeceib	80	11	forms	form	NNS
cord-284409-xiyeceib	80	12	-either	-either	WDT
cord-284409-xiyeceib	80	13	the	the	DT
cord-284409-xiyeceib	80	14	germline	germline	JJ
cord-284409-xiyeceib	80	15	heavy	heavy	JJ
cord-284409-xiyeceib	80	16	chain	chain	NN
cord-284409-xiyeceib	80	17	paired	pair	VBN
cord-284409-xiyeceib	80	18	with	with	IN
cord-284409-xiyeceib	80	19	the	the	DT
cord-284409-xiyeceib	80	20	mature	mature	JJ
cord-284409-xiyeceib	80	21	light	light	JJ
cord-284409-xiyeceib	80	22	chain	chain	NN
cord-284409-xiyeceib	80	23	and	and	CC
cord-284409-xiyeceib	80	24	vice	vice	NN
cord-284409-xiyeceib	80	25	versa	versa	RB
cord-284409-xiyeceib	80	26	-to	-to	:
cord-284409-xiyeceib	80	27	test	test	NN
cord-284409-xiyeceib	80	28	whether	whether	IN
cord-284409-xiyeceib	80	29	they	-PRON-	PRP
cord-284409-xiyeceib	80	30	could	could	MD
cord-284409-xiyeceib	80	31	interact	interact	VB
cord-284409-xiyeceib	80	32	with	with	IN
cord-284409-xiyeceib	80	33	any	any	DT
cord-284409-xiyeceib	80	34	of	of	IN
cord-284409-xiyeceib	80	35	the	the	DT
cord-284409-xiyeceib	80	36	recombinant	recombinant	JJ
cord-284409-xiyeceib	80	37	Envs	Envs	NNP
cord-284409-xiyeceib	80	38	derived	derive	VBN
cord-284409-xiyeceib	80	39	from	from	IN
cord-284409-xiyeceib	80	40	clade	clade	NN
cord-284409-xiyeceib	80	41	A	a	NN
cord-284409-xiyeceib	80	42	,	,	,
cord-284409-xiyeceib	80	43	B	b	NN
cord-284409-xiyeceib	80	44	,	,	,
cord-284409-xiyeceib	80	45	and	and	CC
cord-284409-xiyeceib	80	46	C	c	NN
cord-284409-xiyeceib	80	47	viruses	virus	NNS
cord-284409-xiyeceib	80	48	.	.	.
cord-284409-xiyeceib	81	1	Among	among	IN
cord-284409-xiyeceib	81	2	all	all	PDT
cord-284409-xiyeceib	81	3	the	the	DT
cord-284409-xiyeceib	81	4	recombinant	recombinant	JJ
cord-284409-xiyeceib	81	5	Envs	Envs	NNP
cord-284409-xiyeceib	81	6	tested	test	VBD
cord-284409-xiyeceib	81	7	,	,	,
cord-284409-xiyeceib	81	8	at	at	RB
cord-284409-xiyeceib	81	9	least	least	RBS
cord-284409-xiyeceib	81	10	one	one	CD
cord-284409-xiyeceib	81	11	Env	Env	NNP
cord-284409-xiyeceib	81	12	(	(	-LRB-
cord-284409-xiyeceib	81	13	QH0692	qh0692	NN
cord-284409-xiyeceib	81	14	)	)	-RRB-
cord-284409-xiyeceib	81	15	was	be	VBD
cord-284409-xiyeceib	81	16	found	find	VBN
cord-284409-xiyeceib	81	17	to	to	TO
cord-284409-xiyeceib	81	18	bind	bind	VB
cord-284409-xiyeceib	81	19	a	a	DT
cord-284409-xiyeceib	81	20	b12	b12	NN
cord-284409-xiyeceib	81	21	chimera	chimera	NN
cord-284409-xiyeceib	81	22	with	with	IN
cord-284409-xiyeceib	81	23	a	a	DT
cord-284409-xiyeceib	81	24	mature	mature	JJ
cord-284409-xiyeceib	81	25	heavy	heavy	JJ
cord-284409-xiyeceib	81	26	chain	chain	NN
cord-284409-xiyeceib	81	27	.	.	.
cord-284409-xiyeceib	82	1	However	however	RB
cord-284409-xiyeceib	82	2	,	,	,
cord-284409-xiyeceib	82	3	this	this	DT
cord-284409-xiyeceib	82	4	chimera	chimera	NN
cord-284409-xiyeceib	82	5	failed	fail	VBD
cord-284409-xiyeceib	82	6	to	to	TO
cord-284409-xiyeceib	82	7	mediate	mediate	VB
cord-284409-xiyeceib	82	8	calcium	calcium	NN
cord-284409-xiyeceib	82	9	mobilization	mobilization	NN
cord-284409-xiyeceib	82	10	,	,	,
cord-284409-xiyeceib	82	11	indicating	indicate	VBG
cord-284409-xiyeceib	82	12	no	no	DT
cord-284409-xiyeceib	82	13	BCR	BCR	NNP
cord-284409-xiyeceib	82	14	activation	activation	NN
cord-284409-xiyeceib	82	15	via	via	IN
cord-284409-xiyeceib	82	16	BCR	BCR	NNP
cord-284409-xiyeceib	82	17	-	-	HYPH
cord-284409-xiyeceib	82	18	antigen	antigen	NN
cord-284409-xiyeceib	82	19	engagement	engagement	NN
cord-284409-xiyeceib	82	20	.	.	.
cord-284409-xiyeceib	83	1	In	in	IN
cord-284409-xiyeceib	83	2	other	other	JJ
cord-284409-xiyeceib	83	3	studies	study	NNS
cord-284409-xiyeceib	83	4	,	,	,
cord-284409-xiyeceib	83	5	they	-PRON-	PRP
cord-284409-xiyeceib	83	6	found	find	VBD
cord-284409-xiyeceib	83	7	that	that	IN
cord-284409-xiyeceib	83	8	the	the	DT
cord-284409-xiyeceib	83	9	elimination	elimination	NN
cord-284409-xiyeceib	83	10	of	of	IN
cord-284409-xiyeceib	83	11	certain	certain	JJ
cord-284409-xiyeceib	83	12	conserved	conserved	JJ
cord-284409-xiyeceib	83	13	glycosylation	glycosylation	NN
cord-284409-xiyeceib	83	14	sites	site	NNS
cord-284409-xiyeceib	83	15	on	on	IN
cord-284409-xiyeceib	83	16	Envs	Envs	NNP
cord-284409-xiyeceib	83	17	led	lead	VBD
cord-284409-xiyeceib	83	18	to	to	IN
cord-284409-xiyeceib	83	19	the	the	DT
cord-284409-xiyeceib	83	20	binding	binding	NN
cord-284409-xiyeceib	83	21	of	of	IN
cord-284409-xiyeceib	83	22	germline	germline	JJ
cord-284409-xiyeceib	83	23	versions	version	NNS
cord-284409-xiyeceib	83	24	of	of	IN
cord-284409-xiyeceib	83	25	VRC01	VRC01	NNP
cord-284409-xiyeceib	83	26	and	and	CC
cord-284409-xiyeceib	83	27	NIH45	NIH45	NNP
cord-284409-xiyeceib	83	28	-	-	HYPH
cord-284409-xiyeceib	83	29	46	46	CD
cord-284409-xiyeceib	83	30	and	and	CC
cord-284409-xiyeceib	83	31	BCR	BCR	NNP
cord-284409-xiyeceib	83	32	activation	activation	NN
cord-284409-xiyeceib	83	33	(	(	-LRB-
cord-284409-xiyeceib	83	34	27	27	CD
cord-284409-xiyeceib	83	35	)	)	-RRB-
cord-284409-xiyeceib	83	36	but	but	CC
cord-284409-xiyeceib	83	37	that	that	IN
cord-284409-xiyeceib	83	38	the	the	DT
cord-284409-xiyeceib	83	39	modified	modify	VBN
cord-284409-xiyeceib	83	40	Envs	Envs	NNP
cord-284409-xiyeceib	83	41	did	do	VBD
cord-284409-xiyeceib	83	42	not	not	RB
cord-284409-xiyeceib	83	43	interact	interact	VB
cord-284409-xiyeceib	83	44	with	with	IN
cord-284409-xiyeceib	83	45	PG9	PG9	NNP
cord-284409-xiyeceib	83	46	and	and	CC
cord-284409-xiyeceib	83	47	447	447	CD
cord-284409-xiyeceib	83	48	-	-	HYPH
cord-284409-xiyeceib	83	49	52D	52d	CD
cord-284409-xiyeceib	83	50	germlines	germline	NNS
cord-284409-xiyeceib	83	51	(	(	-LRB-
cord-284409-xiyeceib	83	52	28	28	CD
cord-284409-xiyeceib	83	53	)	)	-RRB-
cord-284409-xiyeceib	83	54	.	.	.
cord-284409-xiyeceib	84	1	Haynes	Haynes	NNP
cord-284409-xiyeceib	84	2	and	and	CC
cord-284409-xiyeceib	84	3	coworkers	coworker	NNS
cord-284409-xiyeceib	84	4	have	have	VBP
cord-284409-xiyeceib	84	5	succeeded	succeed	VBN
cord-284409-xiyeceib	84	6	in	in	IN
cord-284409-xiyeceib	84	7	finding	find	VBG
cord-284409-xiyeceib	84	8	Envs	Envs	NNP
cord-284409-xiyeceib	84	9	capable	capable	JJ
cord-284409-xiyeceib	84	10	of	of	IN
cord-284409-xiyeceib	84	11	engaging	engage	VBG
cord-284409-xiyeceib	84	12	the	the	DT
cord-284409-xiyeceib	84	13	germline	germline	JJ
cord-284409-xiyeceib	84	14	versions	version	NNS
cord-284409-xiyeceib	84	15	of	of	IN
cord-284409-xiyeceib	84	16	a	a	DT
cord-284409-xiyeceib	84	17	CD4bs	cd4bs	NN
cord-284409-xiyeceib	84	18	bnAb	bnAb	''
cord-284409-xiyeceib	84	19	,	,	,
cord-284409-xiyeceib	84	20	CH103	CH103	NNP
cord-284409-xiyeceib	84	21	,	,	,
cord-284409-xiyeceib	84	22	while	while	IN
cord-284409-xiyeceib	84	23	studying	study	VBG
cord-284409-xiyeceib	84	24	the	the	DT
cord-284409-xiyeceib	84	25	co	co	NN
cord-284409-xiyeceib	84	26	-	-	NN
cord-284409-xiyeceib	84	27	evolution	evolution	NN
cord-284409-xiyeceib	84	28	of	of	IN
cord-284409-xiyeceib	84	29	the	the	DT
cord-284409-xiyeceib	84	30	antibody	antibody	NN
cord-284409-xiyeceib	84	31	in	in	IN
cord-284409-xiyeceib	84	32	an	an	DT
cord-284409-xiyeceib	84	33	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	84	34	infected	infect	VBN
cord-284409-xiyeceib	84	35	patient	patient	NN
cord-284409-xiyeceib	84	36	(	(	-LRB-
cord-284409-xiyeceib	84	37	29	29	CD
cord-284409-xiyeceib	84	38	)	)	-RRB-
cord-284409-xiyeceib	84	39	.	.	.
cord-284409-xiyeceib	85	1	They	-PRON-	PRP
cord-284409-xiyeceib	85	2	found	find	VBD
cord-284409-xiyeceib	85	3	that	that	IN
cord-284409-xiyeceib	85	4	CH103	CH103	NNP
cord-284409-xiyeceib	85	5	is	be	VBZ
cord-284409-xiyeceib	85	6	less	less	RBR
cord-284409-xiyeceib	85	7	mutated	mutated	JJ
cord-284409-xiyeceib	85	8	than	than	IN
cord-284409-xiyeceib	85	9	most	most	JJS
cord-284409-xiyeceib	85	10	other	other	JJ
cord-284409-xiyeceib	85	11	CD4bs	CD4bs	NNP
cord-284409-xiyeceib	85	12	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	85	13	,	,	,
cord-284409-xiyeceib	85	14	and	and	CC
cord-284409-xiyeceib	85	15	importantly	importantly	RB
cord-284409-xiyeceib	85	16	that	that	IN
cord-284409-xiyeceib	85	17	the	the	DT
cord-284409-xiyeceib	85	18	unmutated	unmutated	JJ
cord-284409-xiyeceib	85	19	common	common	JJ
cord-284409-xiyeceib	85	20	ancestor	ancestor	NN
cord-284409-xiyeceib	85	21	of	of	IN
cord-284409-xiyeceib	85	22	the	the	DT
cord-284409-xiyeceib	85	23	CH103	CH103	NNP
cord-284409-xiyeceib	85	24	lineage	lineage	NN
cord-284409-xiyeceib	85	25	avidly	avidly	RB
cord-284409-xiyeceib	85	26	bound	bind	VBD
cord-284409-xiyeceib	85	27	the	the	DT
cord-284409-xiyeceib	85	28	transmitted	transmit	VBN
cord-284409-xiyeceib	85	29	/	/	SYM
cord-284409-xiyeceib	85	30	founder	founder	NN
cord-284409-xiyeceib	85	31	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	85	32	Envs	Envs	NNP
cord-284409-xiyeceib	85	33	.	.	.
cord-284409-xiyeceib	86	1	This	this	DT
cord-284409-xiyeceib	86	2	finding	finding	NN
cord-284409-xiyeceib	86	3	suggests	suggest	VBZ
cord-284409-xiyeceib	86	4	that	that	IN
cord-284409-xiyeceib	86	5	early	early	JJ
cord-284409-xiyeceib	86	6	founder	founder	NN
cord-284409-xiyeceib	86	7	Envs	Envs	NNP
cord-284409-xiyeceib	86	8	could	could	MD
cord-284409-xiyeceib	86	9	bind	bind	VB
cord-284409-xiyeceib	86	10	optimally	optimally	RB
cord-284409-xiyeceib	86	11	to	to	IN
cord-284409-xiyeceib	86	12	the	the	DT
cord-284409-xiyeceib	86	13	germline	germline	NN
cord-284409-xiyeceib	86	14	and	and	CC
cord-284409-xiyeceib	86	15	intermediate	intermediate	JJ
cord-284409-xiyeceib	86	16	versions	version	NNS
cord-284409-xiyeceib	86	17	of	of	IN
cord-284409-xiyeceib	86	18	CH103	CH103	NNP
cord-284409-xiyeceib	86	19	,	,	,
cord-284409-xiyeceib	86	20	and	and	CC
cord-284409-xiyeceib	86	21	therefore	therefore	RB
cord-284409-xiyeceib	86	22	,	,	,
cord-284409-xiyeceib	86	23	are	be	VBP
cord-284409-xiyeceib	86	24	promising	promising	JJ
cord-284409-xiyeceib	86	25	vaccine	vaccine	NN
cord-284409-xiyeceib	86	26	immunogens	immunogen	NNS
cord-284409-xiyeceib	86	27	,	,	,
cord-284409-xiyeceib	86	28	representing	represent	VBG
cord-284409-xiyeceib	86	29	an	an	DT
cord-284409-xiyeceib	86	30	important	important	JJ
cord-284409-xiyeceib	86	31	step	step	NN
cord-284409-xiyeceib	86	32	forward	forward	RB
cord-284409-xiyeceib	86	33	in	in	IN
cord-284409-xiyeceib	86	34	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	86	35	vaccine	vaccine	NN
cord-284409-xiyeceib	86	36	development	development	NN
cord-284409-xiyeceib	86	37	.	.	.
cord-284409-xiyeceib	87	1	Similarly	similarly	RB
cord-284409-xiyeceib	87	2	,	,	,
cord-284409-xiyeceib	87	3	the	the	DT
cord-284409-xiyeceib	87	4	maturation	maturation	NN
cord-284409-xiyeceib	87	5	pathway	pathway	NN
cord-284409-xiyeceib	87	6	of	of	IN
cord-284409-xiyeceib	87	7	the	the	DT
cord-284409-xiyeceib	87	8	potent	potent	JJ
cord-284409-xiyeceib	87	9	V1V2-directed	v1v2-directe	VBN
cord-284409-xiyeceib	87	10	HIV	HIV	NNP
cord-284409-xiyeceib	87	11	-	-	HYPH
cord-284409-xiyeceib	87	12	neutralizing	neutralize	VBG
cord-284409-xiyeceib	87	13	antibody	antibody	NN
cord-284409-xiyeceib	87	14	,	,	,
cord-284409-xiyeceib	87	15	CAP256-VRC26	CAP256-VRC26	NNP
cord-284409-xiyeceib	87	16	,	,	,
cord-284409-xiyeceib	87	17	has	have	VBZ
cord-284409-xiyeceib	87	18	been	be	VBN
cord-284409-xiyeceib	87	19	described	describe	VBN
cord-284409-xiyeceib	87	20	,	,	,
cord-284409-xiyeceib	87	21	in	in	IN
cord-284409-xiyeceib	87	22	which	which	WDT
cord-284409-xiyeceib	87	23	a	a	DT
cord-284409-xiyeceib	87	24	germline	germline	NN
cord-284409-xiyeceib	87	25	-	-	HYPH
cord-284409-xiyeceib	87	26	like	like	JJ
cord-284409-xiyeceib	87	27	intermediate	intermediate	JJ
cord-284409-xiyeceib	87	28	with	with	IN
cord-284409-xiyeceib	87	29	a	a	DT
cord-284409-xiyeceib	87	30	35-amino	35-amino	CD
cord-284409-xiyeceib	87	31	acid	acid	NN
cord-284409-xiyeceib	87	32	residue	residue	NN
cord-284409-xiyeceib	87	33	long	long	JJ
cord-284409-xiyeceib	87	34	CDRH3	cdrh3	NN
cord-284409-xiyeceib	87	35	was	be	VBD
cord-284409-xiyeceib	87	36	shown	show	VBN
cord-284409-xiyeceib	87	37	to	to	TO
cord-284409-xiyeceib	87	38	bind	bind	VB
cord-284409-xiyeceib	87	39	and	and	CC
cord-284409-xiyeceib	87	40	neutralize	neutralize	VB
cord-284409-xiyeceib	87	41	the	the	DT
cord-284409-xiyeceib	87	42	superinfecting	superinfecting	NN
cord-284409-xiyeceib	87	43	virus	virus	NN
cord-284409-xiyeceib	87	44	weakly	weakly	RB
cord-284409-xiyeceib	87	45	,	,	,
cord-284409-xiyeceib	87	46	but	but	CC
cord-284409-xiyeceib	87	47	did	do	VBD
cord-284409-xiyeceib	87	48	not	not	RB
cord-284409-xiyeceib	87	49	bind	bind	VB
cord-284409-xiyeceib	87	50	or	or	CC
cord-284409-xiyeceib	87	51	neutralize	neutralize	VB
cord-284409-xiyeceib	87	52	heterologous	heterologous	JJ
cord-284409-xiyeceib	87	53	viruses	virus	NNS
cord-284409-xiyeceib	87	54	(	(	-LRB-
cord-284409-xiyeceib	87	55	30	30	CD
cord-284409-xiyeceib	87	56	)	)	-RRB-
cord-284409-xiyeceib	87	57	.	.	.
cord-284409-xiyeceib	88	1	These	these	DT
cord-284409-xiyeceib	88	2	results	result	NNS
cord-284409-xiyeceib	88	3	suggest	suggest	VBP
cord-284409-xiyeceib	88	4	that	that	IN
cord-284409-xiyeceib	88	5	the	the	DT
cord-284409-xiyeceib	88	6	CAP256-VRC26	CAP256-VRC26	NNP
cord-284409-xiyeceib	88	7	lineage	lineage	NN
cord-284409-xiyeceib	88	8	could	could	MD
cord-284409-xiyeceib	88	9	be	be	VB
cord-284409-xiyeceib	88	10	initiated	initiate	VBN
cord-284409-xiyeceib	88	11	by	by	IN
cord-284409-xiyeceib	88	12	using	use	VBG
cord-284409-xiyeceib	88	13	a	a	DT
cord-284409-xiyeceib	88	14	rare	rare	JJ
cord-284409-xiyeceib	88	15	superinfecting	superinfecting	NN
cord-284409-xiyeceib	88	16	-	-	HYPH
cord-284409-xiyeceib	88	17	virus	virus	NN
cord-284409-xiyeceib	88	18	-	-	HYPH
cord-284409-xiyeceib	88	19	like	like	JJ
cord-284409-xiyeceib	88	20	V1V2	V1V2	NNP
cord-284409-xiyeceib	88	21	Env	Env	NNP
cord-284409-xiyeceib	88	22	.	.	.
cord-284409-xiyeceib	89	1	In	in	IN
cord-284409-xiyeceib	89	2	another	another	DT
cord-284409-xiyeceib	89	3	successful	successful	JJ
cord-284409-xiyeceib	89	4	effort	effort	NN
cord-284409-xiyeceib	89	5	in	in	IN
cord-284409-xiyeceib	89	6	identifying	identify	VBG
cord-284409-xiyeceib	89	7	an	an	DT
cord-284409-xiyeceib	89	8	Env	Env	NNP
cord-284409-xiyeceib	89	9	that	that	WDT
cord-284409-xiyeceib	89	10	could	could	MD
cord-284409-xiyeceib	89	11	engage	engage	VB
cord-284409-xiyeceib	89	12	the	the	DT
cord-284409-xiyeceib	89	13	germline	germline	JJ
cord-284409-xiyeceib	89	14	versions	version	NNS
cord-284409-xiyeceib	89	15	of	of	IN
cord-284409-xiyeceib	89	16	bnAbs	bnabs	NN
cord-284409-xiyeceib	89	17	,	,	,
cord-284409-xiyeceib	89	18	Scheif	Scheif	NNP
cord-284409-xiyeceib	89	19	and	and	CC
cord-284409-xiyeceib	89	20	coworkers	coworker	NNS
cord-284409-xiyeceib	89	21	devised	devise	VBD
cord-284409-xiyeceib	89	22	a	a	DT
cord-284409-xiyeceib	89	23	computation	computation	NN
cord-284409-xiyeceib	89	24	-	-	HYPH
cord-284409-xiyeceib	89	25	guided	guide	VBN
cord-284409-xiyeceib	89	26	approach	approach	NN
cord-284409-xiyeceib	89	27	combined	combine	VBN
cord-284409-xiyeceib	89	28	with	with	IN
cord-284409-xiyeceib	89	29	in	in	FW
cord-284409-xiyeceib	89	30	vitro	vitro	FW
cord-284409-xiyeceib	89	31	screening	screen	VBG
cord-284409-xiyeceib	89	32	to	to	TO
cord-284409-xiyeceib	89	33	engineer	engineer	VB
cord-284409-xiyeceib	89	34	a	a	DT
cord-284409-xiyeceib	89	35	gp120	gp120	CD
cord-284409-xiyeceib	89	36	outer	outer	JJ
cord-284409-xiyeceib	89	37	domain	domain	NN
cord-284409-xiyeceib	89	38	.	.	.
cord-284409-xiyeceib	90	1	The	the	DT
cord-284409-xiyeceib	90	2	designed	design	VBN
cord-284409-xiyeceib	90	3	protein	protein	NN
cord-284409-xiyeceib	90	4	not	not	RB
cord-284409-xiyeceib	90	5	only	only	RB
cord-284409-xiyeceib	90	6	bound	bind	VBN
cord-284409-xiyeceib	90	7	to	to	IN
cord-284409-xiyeceib	90	8	multiple	multiple	JJ
cord-284409-xiyeceib	90	9	VRC01-class	VRC01-class	NNP
cord-284409-xiyeceib	90	10	bnAbs	bnabs	NN
cord-284409-xiyeceib	90	11	and	and	CC
cord-284409-xiyeceib	90	12	their	-PRON-	PRP$
cord-284409-xiyeceib	90	13	germline	germline	JJ
cord-284409-xiyeceib	90	14	precursors	precursor	NNS
cord-284409-xiyeceib	90	15	but	but	CC
cord-284409-xiyeceib	90	16	also	also	RB
cord-284409-xiyeceib	90	17	activated	activate	VBN
cord-284409-xiyeceib	90	18	B	b	NN
cord-284409-xiyeceib	90	19	cells	cell	NNS
cord-284409-xiyeceib	90	20	expressing	express	VBG
cord-284409-xiyeceib	90	21	diverse	diverse	JJ
cord-284409-xiyeceib	90	22	intermediates	intermediate	NNS
cord-284409-xiyeceib	90	23	of	of	IN
cord-284409-xiyeceib	90	24	the	the	DT
cord-284409-xiyeceib	90	25	bnAbs	bnabs	NN
cord-284409-xiyeceib	90	26	(	(	-LRB-
cord-284409-xiyeceib	90	27	31	31	CD
cord-284409-xiyeceib	90	28	)	)	-RRB-
cord-284409-xiyeceib	90	29	.	.	.
cord-284409-xiyeceib	91	1	Therefore	therefore	RB
cord-284409-xiyeceib	91	2	,	,	,
cord-284409-xiyeceib	91	3	priming	prime	VBG
cord-284409-xiyeceib	91	4	with	with	IN
cord-284409-xiyeceib	91	5	the	the	DT
cord-284409-xiyeceib	91	6	protein	protein	NN
cord-284409-xiyeceib	91	7	and	and	CC
cord-284409-xiyeceib	91	8	subsequent	subsequent	JJ
cord-284409-xiyeceib	91	9	boosting	boosting	NN
cord-284409-xiyeceib	91	10	with	with	IN
cord-284409-xiyeceib	91	11	more	more	JJR
cord-284409-xiyeceib	91	12	native	native	JJ
cord-284409-xiyeceib	91	13	immunogens	immunogen	NNS
cord-284409-xiyeceib	91	14	could	could	MD
cord-284409-xiyeceib	91	15	help	help	VB
cord-284409-xiyeceib	91	16	induce	induce	VB
cord-284409-xiyeceib	91	17	early	early	JJ
cord-284409-xiyeceib	91	18	somatic	somatic	JJ
cord-284409-xiyeceib	91	19	mutations	mutation	NNS
cord-284409-xiyeceib	91	20	and	and	CC
cord-284409-xiyeceib	91	21	the	the	DT
cord-284409-xiyeceib	91	22	ultimate	ultimate	JJ
cord-284409-xiyeceib	91	23	elicitation	elicitation	NN
cord-284409-xiyeceib	91	24	of	of	IN
cord-284409-xiyeceib	91	25	VRC01-class	VRC01-class	NNP
cord-284409-xiyeceib	91	26	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	91	27	.	.	.
cord-284409-xiyeceib	92	1	Interestingly	interestingly	RB
cord-284409-xiyeceib	92	2	,	,	,
cord-284409-xiyeceib	92	3	Nussenzweig	Nussenzweig	NNP
cord-284409-xiyeceib	92	4	and	and	CC
cord-284409-xiyeceib	92	5	coworkers	coworker	NNS
cord-284409-xiyeceib	92	6	'	'	POS
cord-284409-xiyeceib	92	7	study	study	NN
cord-284409-xiyeceib	92	8	showed	show	VBD
cord-284409-xiyeceib	92	9	that	that	IN
cord-284409-xiyeceib	92	10	somatic	somatic	JJ
cord-284409-xiyeceib	92	11	mutations	mutation	NNS
cord-284409-xiyeceib	92	12	of	of	IN
cord-284409-xiyeceib	92	13	the	the	DT
cord-284409-xiyeceib	92	14	FRs	FRs	NNP
cord-284409-xiyeceib	92	15	and	and	CC
cord-284409-xiyeceib	92	16	insertions	insertion	NNS
cord-284409-xiyeceib	92	17	of	of	IN
cord-284409-xiyeceib	92	18	some	some	DT
cord-284409-xiyeceib	92	19	bnAbs	bnabs	NN
cord-284409-xiyeceib	92	20	are	be	VBP
cord-284409-xiyeceib	92	21	required	require	VBN
cord-284409-xiyeceib	92	22	for	for	IN
cord-284409-xiyeceib	92	23	their	-PRON-	PRP$
cord-284409-xiyeceib	92	24	broad	broad	JJ
cord-284409-xiyeceib	92	25	and	and	CC
cord-284409-xiyeceib	92	26	potent	potent	JJ
cord-284409-xiyeceib	92	27	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	92	28	neutralizing	neutralize	VBG
cord-284409-xiyeceib	92	29	activity	activity	NN
cord-284409-xiyeceib	92	30	(	(	-LRB-
cord-284409-xiyeceib	92	31	32	32	CD
cord-284409-xiyeceib	92	32	)	)	-RRB-
cord-284409-xiyeceib	92	33	.	.	.
cord-284409-xiyeceib	93	1	Based	base	VBN
cord-284409-xiyeceib	93	2	on	on	IN
cord-284409-xiyeceib	93	3	structural	structural	JJ
cord-284409-xiyeceib	93	4	information	information	NN
cord-284409-xiyeceib	93	5	,	,	,
cord-284409-xiyeceib	93	6	they	-PRON-	PRP
cord-284409-xiyeceib	93	7	made	make	VBD
cord-284409-xiyeceib	93	8	different	different	JJ
cord-284409-xiyeceib	93	9	germline	germline	JJ
cord-284409-xiyeceib	93	10	versions	version	NNS
cord-284409-xiyeceib	93	11	of	of	IN
cord-284409-xiyeceib	93	12	VRC01	VRC01	NNP
cord-284409-xiyeceib	93	13	,	,	,
cord-284409-xiyeceib	93	14	NIH45	NIH45	NNP
cord-284409-xiyeceib	93	15	-	-	HYPH
cord-284409-xiyeceib	93	16	46	46	CD
cord-284409-xiyeceib	93	17	,	,	,
cord-284409-xiyeceib	93	18	12A21	12a21	CD
cord-284409-xiyeceib	93	19	,	,	,
cord-284409-xiyeceib	93	20	and	and	CC
cord-284409-xiyeceib	93	21	3BNC117	3BNC117	NNP
cord-284409-xiyeceib	93	22	,	,	,
cord-284409-xiyeceib	93	23	and	and	CC
cord-284409-xiyeceib	93	24	found	find	VBD
cord-284409-xiyeceib	93	25	that	that	IN
cord-284409-xiyeceib	93	26	mutations	mutation	NNS
cord-284409-xiyeceib	93	27	in	in	IN
cord-284409-xiyeceib	93	28	FRs	fr	NNS
cord-284409-xiyeceib	93	29	were	be	VBD
cord-284409-xiyeceib	93	30	also	also	RB
cord-284409-xiyeceib	93	31	essential	essential	JJ
cord-284409-xiyeceib	93	32	for	for	IN
cord-284409-xiyeceib	93	33	binding	bind	VBG
cord-284409-xiyeceib	93	34	,	,	,
cord-284409-xiyeceib	93	35	breadth	breadth	NN
cord-284409-xiyeceib	93	36	,	,	,
cord-284409-xiyeceib	93	37	and	and	CC
cord-284409-xiyeceib	93	38	potency	potency	NN
cord-284409-xiyeceib	93	39	of	of	IN
cord-284409-xiyeceib	93	40	most	most	JJS
cord-284409-xiyeceib	93	41	bnAbs	bnabs	NN
cord-284409-xiyeceib	93	42	.	.	.
cord-284409-xiyeceib	94	1	This	this	DT
cord-284409-xiyeceib	94	2	suggested	suggest	VBD
cord-284409-xiyeceib	94	3	that	that	IN
cord-284409-xiyeceib	94	4	certain	certain	JJ
cord-284409-xiyeceib	94	5	framework	framework	NN
cord-284409-xiyeceib	94	6	mutations	mutation	NNS
cord-284409-xiyeceib	94	7	could	could	MD
cord-284409-xiyeceib	94	8	be	be	VB
cord-284409-xiyeceib	94	9	critical	critical	JJ
cord-284409-xiyeceib	94	10	and	and	CC
cord-284409-xiyeceib	94	11	should	should	MD
cord-284409-xiyeceib	94	12	be	be	VB
cord-284409-xiyeceib	94	13	preserved	preserve	VBN
cord-284409-xiyeceib	94	14	for	for	IN
cord-284409-xiyeceib	94	15	designing	design	VBG
cord-284409-xiyeceib	94	16	the	the	DT
cord-284409-xiyeceib	94	17	intermediates	intermediate	NNS
cord-284409-xiyeceib	94	18	of	of	IN
cord-284409-xiyeceib	94	19	such	such	JJ
cord-284409-xiyeceib	94	20	bnAbs	bnabs	NN
cord-284409-xiyeceib	94	21	.	.	.
cord-284409-xiyeceib	95	1	Several	several	JJ
cord-284409-xiyeceib	95	2	other	other	JJ
cord-284409-xiyeceib	95	3	studies	study	NNS
cord-284409-xiyeceib	95	4	mining	mine	VBG
cord-284409-xiyeceib	95	5	the	the	DT
cord-284409-xiyeceib	95	6	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	95	7	infected	infect	VBD
cord-284409-xiyeceib	95	8	donors	donor	NNS
cord-284409-xiyeceib	95	9	'	'	POS
cord-284409-xiyeceib	95	10	antibodyomes	antibodyome	NNS
cord-284409-xiyeceib	95	11	(	(	-LRB-
cord-284409-xiyeceib	95	12	33	33	CD
cord-284409-xiyeceib	95	13	-	-	SYM
cord-284409-xiyeceib	95	14	35	35	CD
cord-284409-xiyeceib	95	15	)	)	-RRB-
cord-284409-xiyeceib	95	16	revealed	reveal	VBD
cord-284409-xiyeceib	95	17	putative	putative	JJ
cord-284409-xiyeceib	95	18	intermediates	intermediate	NNS
cord-284409-xiyeceib	95	19	of	of	IN
cord-284409-xiyeceib	95	20	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	95	21	.	.	.
cord-284409-xiyeceib	96	1	Many	many	JJ
cord-284409-xiyeceib	96	2	of	of	IN
cord-284409-xiyeceib	96	3	them	-PRON-	PRP
cord-284409-xiyeceib	96	4	with	with	IN
cord-284409-xiyeceib	96	5	lower	low	JJR
cord-284409-xiyeceib	96	6	levels	level	NNS
cord-284409-xiyeceib	96	7	of	of	IN
cord-284409-xiyeceib	96	8	somatic	somatic	JJ
cord-284409-xiyeceib	96	9	hyper	hyper	NN
cord-284409-xiyeceib	96	10	mutations	mutation	NNS
cord-284409-xiyeceib	96	11	could	could	MD
cord-284409-xiyeceib	96	12	bind	bind	VB
cord-284409-xiyeceib	96	13	to	to	IN
cord-284409-xiyeceib	96	14	selective	selective	JJ
cord-284409-xiyeceib	96	15	Envs	Envs	NNP
cord-284409-xiyeceib	96	16	;	;	:
cord-284409-xiyeceib	96	17	for	for	IN
cord-284409-xiyeceib	96	18	example	example	NN
cord-284409-xiyeceib	96	19	,	,	,
cord-284409-xiyeceib	96	20	intermediates	intermediate	NNS
cord-284409-xiyeceib	96	21	of	of	IN
cord-284409-xiyeceib	96	22	PGT121	PGT121	NNP
cord-284409-xiyeceib	96	23	-	-	HYPH
cord-284409-xiyeceib	96	24	134	134	CD
cord-284409-xiyeceib	96	25	were	be	VBD
cord-284409-xiyeceib	96	26	able	able	JJ
cord-284409-xiyeceib	96	27	to	to	TO
cord-284409-xiyeceib	96	28	preferentially	preferentially	RB
cord-284409-xiyeceib	96	29	bind	bind	VB
cord-284409-xiyeceib	96	30	native	native	JJ
cord-284409-xiyeceib	96	31	Envs	Envs	NNP
cord-284409-xiyeceib	96	32	relative	relative	JJ
cord-284409-xiyeceib	96	33	to	to	IN
cord-284409-xiyeceib	96	34	monomeric	monomeric	JJ
cord-284409-xiyeceib	96	35	gp120	gp120	NNP
cord-284409-xiyeceib	96	36	(	(	-LRB-
cord-284409-xiyeceib	96	37	36	36	CD
cord-284409-xiyeceib	96	38	)	)	-RRB-
cord-284409-xiyeceib	96	39	.	.	.
cord-284409-xiyeceib	97	1	We	-PRON-	PRP
cord-284409-xiyeceib	97	2	also	also	RB
cord-284409-xiyeceib	97	3	identified	identify	VBD
cord-284409-xiyeceib	97	4	2F5-like	2f5-like	CD
cord-284409-xiyeceib	97	5	antibodies	antibody	NNS
cord-284409-xiyeceib	97	6	(	(	-LRB-
cord-284409-xiyeceib	97	7	m66	m66	NN
cord-284409-xiyeceib	97	8	and	and	CC
cord-284409-xiyeceib	97	9	m66.6	m66.6	NN
cord-284409-xiyeceib	97	10	)	)	-RRB-
cord-284409-xiyeceib	97	11	with	with	IN
cord-284409-xiyeceib	97	12	much	much	RB
cord-284409-xiyeceib	97	13	fewer	few	JJR
cord-284409-xiyeceib	97	14	mutations	mutation	NNS
cord-284409-xiyeceib	97	15	than	than	IN
cord-284409-xiyeceib	97	16	2F5	2f5	CD
cord-284409-xiyeceib	97	17	and	and	CC
cord-284409-xiyeceib	97	18	suggested	suggest	VBD
cord-284409-xiyeceib	97	19	their	-PRON-	PRP$
cord-284409-xiyeceib	97	20	use	use	NN
cord-284409-xiyeceib	97	21	as	as	IN
cord-284409-xiyeceib	97	22	a	a	DT
cord-284409-xiyeceib	97	23	model	model	NN
cord-284409-xiyeceib	97	24	system	system	NN
cord-284409-xiyeceib	97	25	for	for	IN
cord-284409-xiyeceib	97	26	elicitation	elicitation	NN
cord-284409-xiyeceib	97	27	of	of	IN
cord-284409-xiyeceib	97	28	such	such	JJ
cord-284409-xiyeceib	97	29	antibodies	antibody	NNS
cord-284409-xiyeceib	97	30	(	(	-LRB-
cord-284409-xiyeceib	97	31	37	37	CD
cord-284409-xiyeceib	97	32	,	,	,
cord-284409-xiyeceib	97	33	38	38	CD
cord-284409-xiyeceib	97	34	)	)	-RRB-
cord-284409-xiyeceib	97	35	.	.	.
cord-284409-xiyeceib	98	1	All	all	PDT
cord-284409-xiyeceib	98	2	these	these	DT
cord-284409-xiyeceib	98	3	newly	newly	RB
cord-284409-xiyeceib	98	4	discovered	discover	VBN
cord-284409-xiyeceib	98	5	bnAbs	bnabs	NN
cord-284409-xiyeceib	98	6	raise	raise	VBP
cord-284409-xiyeceib	98	7	the	the	DT
cord-284409-xiyeceib	98	8	hopes	hope	NNS
cord-284409-xiyeceib	98	9	for	for	IN
cord-284409-xiyeceib	98	10	effective	effective	JJ
cord-284409-xiyeceib	98	11	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	98	12	vaccine	vaccine	NN
cord-284409-xiyeceib	98	13	development	development	NN
cord-284409-xiyeceib	98	14	as	as	IN
cord-284409-xiyeceib	98	15	they	-PRON-	PRP
cord-284409-xiyeceib	98	16	reveal	reveal	VBP
cord-284409-xiyeceib	98	17	characteristic	characteristic	JJ
cord-284409-xiyeceib	98	18	features	feature	NNS
cord-284409-xiyeceib	98	19	of	of	IN
cord-284409-xiyeceib	98	20	bnAbs	bnabs	NN
cord-284409-xiyeceib	98	21	that	that	WDT
cord-284409-xiyeceib	98	22	could	could	MD
cord-284409-xiyeceib	98	23	help	help	VB
cord-284409-xiyeceib	98	24	us	-PRON-	PRP
cord-284409-xiyeceib	98	25	understand	understand	VB
cord-284409-xiyeceib	98	26	the	the	DT
cord-284409-xiyeceib	98	27	immunological	immunological	JJ
cord-284409-xiyeceib	98	28	basis	basis	NN
cord-284409-xiyeceib	98	29	critical	critical	JJ
cord-284409-xiyeceib	98	30	for	for	IN
cord-284409-xiyeceib	98	31	their	-PRON-	PRP$
cord-284409-xiyeceib	98	32	production	production	NN
cord-284409-xiyeceib	98	33	and	and	CC
cord-284409-xiyeceib	98	34	also	also	RB
cord-284409-xiyeceib	98	35	serve	serve	VBP
cord-284409-xiyeceib	98	36	as	as	IN
cord-284409-xiyeceib	98	37	templates	template	NNS
cord-284409-xiyeceib	98	38	for	for	IN
cord-284409-xiyeceib	98	39	rational	rational	JJ
cord-284409-xiyeceib	98	40	vaccine	vaccine	NN
cord-284409-xiyeceib	98	41	design	design	NN
cord-284409-xiyeceib	98	42	.	.	.
cord-284409-xiyeceib	99	1	Therefore	therefore	RB
cord-284409-xiyeceib	99	2	,	,	,
cord-284409-xiyeceib	99	3	the	the	DT
cord-284409-xiyeceib	99	4	focus	focus	NN
cord-284409-xiyeceib	99	5	has	have	VBZ
cord-284409-xiyeceib	99	6	been	be	VBN
cord-284409-xiyeceib	99	7	dramatically	dramatically	RB
cord-284409-xiyeceib	99	8	shifted	shift	VBN
cord-284409-xiyeceib	99	9	to	to	TO
cord-284409-xiyeceib	99	10	explore	explore	VB
cord-284409-xiyeceib	99	11	and	and	CC
cord-284409-xiyeceib	99	12	overcome	overcome	VB
cord-284409-xiyeceib	99	13	the	the	DT
cord-284409-xiyeceib	99	14	immunological	immunological	JJ
cord-284409-xiyeceib	99	15	hurdles	hurdle	NNS
cord-284409-xiyeceib	99	16	associated	associate	VBN
cord-284409-xiyeceib	99	17	with	with	IN
cord-284409-xiyeceib	99	18	the	the	DT
cord-284409-xiyeceib	99	19	elicitation	elicitation	NN
cord-284409-xiyeceib	99	20	of	of	IN
cord-284409-xiyeceib	99	21	bnAbs	bnabs	NN
cord-284409-xiyeceib	99	22	,	,	,
cord-284409-xiyeceib	99	23	namely	namely	RB
cord-284409-xiyeceib	99	24	,	,	,
cord-284409-xiyeceib	99	25	extensive	extensive	JJ
cord-284409-xiyeceib	99	26	somatic	somatic	JJ
cord-284409-xiyeceib	99	27	mutations	mutation	NNS
cord-284409-xiyeceib	99	28	of	of	IN
cord-284409-xiyeceib	99	29	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	99	30	.	.	.
cord-284409-xiyeceib	100	1	Major	major	JJ
cord-284409-xiyeceib	100	2	challenges	challenge	NNS
cord-284409-xiyeceib	100	3	remain	remain	VBP
cord-284409-xiyeceib	100	4	in	in	IN
cord-284409-xiyeceib	100	5	identification	identification	NN
cord-284409-xiyeceib	100	6	of	of	IN
cord-284409-xiyeceib	100	7	intermediates	intermediate	NNS
cord-284409-xiyeceib	100	8	with	with	IN
cord-284409-xiyeceib	100	9	a	a	DT
cord-284409-xiyeceib	100	10	minimal	minimal	JJ
cord-284409-xiyeceib	100	11	number	number	NN
cord-284409-xiyeceib	100	12	of	of	IN
cord-284409-xiyeceib	100	13	mutations	mutation	NNS
cord-284409-xiyeceib	100	14	,	,	,
cord-284409-xiyeceib	100	15	and	and	CC
cord-284409-xiyeceib	100	16	appropriate	appropriate	JJ
cord-284409-xiyeceib	100	17	Env	Env	NNP
cord-284409-xiyeceib	100	18	immunogens	immunogen	NNS
cord-284409-xiyeceib	100	19	that	that	WDT
cord-284409-xiyeceib	100	20	would	would	MD
cord-284409-xiyeceib	100	21	bind	bind	VB
cord-284409-xiyeceib	100	22	such	such	JJ
cord-284409-xiyeceib	100	23	intermediates	intermediate	NNS
cord-284409-xiyeceib	100	24	and	and	CC
cord-284409-xiyeceib	100	25	activate	activate	VB
cord-284409-xiyeceib	100	26	BCRs	bcr	NNS
cord-284409-xiyeceib	100	27	,	,	,
cord-284409-xiyeceib	100	28	which	which	WDT
cord-284409-xiyeceib	100	29	can	can	MD
cord-284409-xiyeceib	100	30	lead	lead	VB
cord-284409-xiyeceib	100	31	to	to	IN
cord-284409-xiyeceib	100	32	the	the	DT
cord-284409-xiyeceib	100	33	maturation	maturation	NN
cord-284409-xiyeceib	100	34	of	of	IN
cord-284409-xiyeceib	100	35	the	the	DT
cord-284409-xiyeceib	100	36	intermediate	intermediate	JJ
cord-284409-xiyeceib	100	37	antibodies	antibody	NNS
cord-284409-xiyeceib	100	38	to	to	IN
cord-284409-xiyeceib	100	39	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	100	40	.	.	.
cord-284409-xiyeceib	101	1	Recently	recently	RB
cord-284409-xiyeceib	101	2	,	,	,
cord-284409-xiyeceib	101	3	new	new	JJ
cord-284409-xiyeceib	101	4	paradigms	paradigm	NNS
cord-284409-xiyeceib	101	5	that	that	WDT
cord-284409-xiyeceib	101	6	better	well	RBR
cord-284409-xiyeceib	101	7	fit	fit	VBP
cord-284409-xiyeceib	101	8	our	-PRON-	PRP$
cord-284409-xiyeceib	101	9	increased	increased	JJ
cord-284409-xiyeceib	101	10	knowledge	knowledge	NN
cord-284409-xiyeceib	101	11	of	of	IN
cord-284409-xiyeceib	101	12	HIV	HIV	NNP
cord-284409-xiyeceib	101	13	immunopathology	immunopathology	NN
cord-284409-xiyeceib	101	14	and	and	CC
cord-284409-xiyeceib	101	15	which	which	WDT
cord-284409-xiyeceib	101	16	may	may	MD
cord-284409-xiyeceib	101	17	be	be	VB
cord-284409-xiyeceib	101	18	more	more	RBR
cord-284409-xiyeceib	101	19	helpful	helpful	JJ
cord-284409-xiyeceib	101	20	in	in	IN
cord-284409-xiyeceib	101	21	guiding	guide	VBG
cord-284409-xiyeceib	101	22	future	future	JJ
cord-284409-xiyeceib	101	23	vaccine	vaccine	NN
cord-284409-xiyeceib	101	24	research	research	NN
cord-284409-xiyeceib	101	25	than	than	IN
cord-284409-xiyeceib	101	26	did	do	VBD
cord-284409-xiyeceib	101	27	past	past	JJ
cord-284409-xiyeceib	101	28	unsuccessful	unsuccessful	JJ
cord-284409-xiyeceib	101	29	approaches	approach	NNS
cord-284409-xiyeceib	101	30	were	be	VBD
cord-284409-xiyeceib	101	31	discussed	discuss	VBN
cord-284409-xiyeceib	101	32	(	(	-LRB-
cord-284409-xiyeceib	101	33	17	17	CD
cord-284409-xiyeceib	101	34	)	)	-RRB-
cord-284409-xiyeceib	101	35	.	.	.
cord-284409-xiyeceib	102	1	We	-PRON-	PRP
cord-284409-xiyeceib	102	2	previously	previously	RB
cord-284409-xiyeceib	102	3	characterized	characterize	VBD
cord-284409-xiyeceib	102	4	the	the	DT
cord-284409-xiyeceib	102	5	human	human	JJ
cord-284409-xiyeceib	102	6	cord	cord	NN
cord-284409-xiyeceib	102	7	blood	blood	NN
cord-284409-xiyeceib	102	8	cell	cell	NN
cord-284409-xiyeceib	102	9	-	-	HYPH
cord-284409-xiyeceib	102	10	derived	derive	VBN
cord-284409-xiyeceib	102	11	IgM	IgM	NNP
cord-284409-xiyeceib	102	12	antibodies	antibody	NNS
cord-284409-xiyeceib	102	13	using	use	VBG
cord-284409-xiyeceib	102	14	454	454	CD
cord-284409-xiyeceib	102	15	sequencing	sequencing	NN
cord-284409-xiyeceib	102	16	to	to	TO
cord-284409-xiyeceib	102	17	study	study	VB
cord-284409-xiyeceib	102	18	gene	gene	NN
cord-284409-xiyeceib	102	19	diversity	diversity	NN
cord-284409-xiyeceib	102	20	and	and	CC
cord-284409-xiyeceib	102	21	somatic	somatic	JJ
cord-284409-xiyeceib	102	22	mutations	mutation	NNS
cord-284409-xiyeceib	102	23	(	(	-LRB-
cord-284409-xiyeceib	102	24	19	19	CD
cord-284409-xiyeceib	102	25	)	)	-RRB-
cord-284409-xiyeceib	102	26	.	.	.
cord-284409-xiyeceib	103	1	Naïve	naïve	JJ
cord-284409-xiyeceib	103	2	germline	germline	JJ
cord-284409-xiyeceib	103	3	antibody	antibody	NN
cord-284409-xiyeceib	103	4	repertoires	repertoire	NNS
cord-284409-xiyeceib	103	5	,	,	,
cord-284409-xiyeceib	103	6	particularly	particularly	RB
cord-284409-xiyeceib	103	7	from	from	IN
cord-284409-xiyeceib	103	8	babies	baby	NNS
cord-284409-xiyeceib	103	9	,	,	,
cord-284409-xiyeceib	103	10	may	may	MD
cord-284409-xiyeceib	103	11	be	be	VB
cord-284409-xiyeceib	103	12	quite	quite	RB
cord-284409-xiyeceib	103	13	unique	unique	JJ
cord-284409-xiyeceib	103	14	for	for	IN
cord-284409-xiyeceib	103	15	understanding	understand	VBG
cord-284409-xiyeceib	103	16	the	the	DT
cord-284409-xiyeceib	103	17	B	b	NN
cord-284409-xiyeceib	103	18	cell	cell	NN
cord-284409-xiyeceib	103	19	maturation	maturation	NN
cord-284409-xiyeceib	103	20	pathways	pathway	NNS
cord-284409-xiyeceib	103	21	,	,	,
cord-284409-xiyeceib	103	22	as	as	IN
cord-284409-xiyeceib	103	23	they	-PRON-	PRP
cord-284409-xiyeceib	103	24	can	can	MD
cord-284409-xiyeceib	103	25	also	also	RB
cord-284409-xiyeceib	103	26	mount	mount	VB
cord-284409-xiyeceib	103	27	an	an	DT
cord-284409-xiyeceib	103	28	immune	immune	JJ
cord-284409-xiyeceib	103	29	response	response	NN
cord-284409-xiyeceib	103	30	against	against	IN
cord-284409-xiyeceib	103	31	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	103	32	as	as	IN
cord-284409-xiyeceib	103	33	recently	recently	RB
cord-284409-xiyeceib	103	34	found	find	VBN
cord-284409-xiyeceib	103	35	(	(	-LRB-
cord-284409-xiyeceib	103	36	39	39	CD
cord-284409-xiyeceib	103	37	)	)	-RRB-
cord-284409-xiyeceib	103	38	.	.	.
cord-284409-xiyeceib	104	1	Our	-PRON-	PRP$
cord-284409-xiyeceib	104	2	earlier	early	JJR
cord-284409-xiyeceib	104	3	gene	gene	NN
cord-284409-xiyeceib	104	4	usage	usage	NN
cord-284409-xiyeceib	104	5	analysis	analysis	NN
cord-284409-xiyeceib	104	6	of	of	IN
cord-284409-xiyeceib	104	7	the	the	DT
cord-284409-xiyeceib	104	8	cord	cord	NN
cord-284409-xiyeceib	104	9	blood	blood	NN
cord-284409-xiyeceib	104	10	IgM	IgM	NNP
cord-284409-xiyeceib	104	11	repertoire	repertoire	NN
cord-284409-xiyeceib	104	12	showed	show	VBD
cord-284409-xiyeceib	104	13	the	the	DT
cord-284409-xiyeceib	104	14	biased	biased	JJ
cord-284409-xiyeceib	104	15	IGHV	IGHV	NNP
cord-284409-xiyeceib	104	16	gene	gene	NN
cord-284409-xiyeceib	104	17	usages	usage	NNS
cord-284409-xiyeceib	104	18	(	(	-LRB-
cord-284409-xiyeceib	104	19	19	19	CD
cord-284409-xiyeceib	104	20	)	)	-RRB-
cord-284409-xiyeceib	104	21	as	as	RB
cord-284409-xiyeceib	104	22	similar	similar	JJ
cord-284409-xiyeceib	104	23	to	to	IN
cord-284409-xiyeceib	104	24	adult	adult	NN
cord-284409-xiyeceib	104	25	IgM	IgM	NNP
cord-284409-xiyeceib	104	26	repertoires	repertoire	NNS
cord-284409-xiyeceib	104	27	(	(	-LRB-
cord-284409-xiyeceib	104	28	40	40	CD
cord-284409-xiyeceib	104	29	)	)	-RRB-
cord-284409-xiyeceib	104	30	.	.	.
cord-284409-xiyeceib	105	1	However	however	RB
cord-284409-xiyeceib	105	2	,	,	,
cord-284409-xiyeceib	105	3	we	-PRON-	PRP
cord-284409-xiyeceib	105	4	already	already	RB
cord-284409-xiyeceib	105	5	noted	note	VBD
cord-284409-xiyeceib	105	6	that	that	IN
cord-284409-xiyeceib	105	7	the	the	DT
cord-284409-xiyeceib	105	8	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	105	9	-	-	HYPH
cord-284409-xiyeceib	105	10	2	2	CD
cord-284409-xiyeceib	105	11	gene	gene	NN
cord-284409-xiyeceib	105	12	usage	usage	NN
cord-284409-xiyeceib	105	13	was	be	VBD
cord-284409-xiyeceib	105	14	significantly	significantly	RB
cord-284409-xiyeceib	105	15	higher	high	JJR
cord-284409-xiyeceib	105	16	in	in	IN
cord-284409-xiyeceib	105	17	the	the	DT
cord-284409-xiyeceib	105	18	cord	cord	NN
cord-284409-xiyeceib	105	19	blood	blood	NN
cord-284409-xiyeceib	105	20	IgM	IgM	NNP
cord-284409-xiyeceib	105	21	repertoire	repertoire	NNP
cord-284409-xiyeceib	105	22	,	,	,
cord-284409-xiyeceib	105	23	i.e.	i.e.	FW
cord-284409-xiyeceib	105	24	,	,	,
cord-284409-xiyeceib	105	25	an	an	DT
cord-284409-xiyeceib	105	26	overall	overall	JJ
cord-284409-xiyeceib	105	27	contribution	contribution	NN
cord-284409-xiyeceib	105	28	of	of	IN
cord-284409-xiyeceib	105	29	20	20	CD
cord-284409-xiyeceib	105	30	%	%	NN
cord-284409-xiyeceib	105	31	as	as	IN
cord-284409-xiyeceib	105	32	compared	compare	VBN
cord-284409-xiyeceib	105	33	to	to	IN
cord-284409-xiyeceib	105	34	8	8	CD
cord-284409-xiyeceib	105	35	%	%	NN
cord-284409-xiyeceib	105	36	in	in	IN
cord-284409-xiyeceib	105	37	adult	adult	NN
cord-284409-xiyeceib	105	38	IgM	IgM	NNP
cord-284409-xiyeceib	105	39	repertoires	repertoire	NNS
cord-284409-xiyeceib	105	40	.	.	.
cord-284409-xiyeceib	106	1	This	this	DT
cord-284409-xiyeceib	106	2	suggested	suggest	VBD
cord-284409-xiyeceib	106	3	that	that	IN
cord-284409-xiyeceib	106	4	the	the	DT
cord-284409-xiyeceib	106	5	cord	cord	NN
cord-284409-xiyeceib	106	6	blood	blood	NN
cord-284409-xiyeceib	106	7	IgM	IgM	NNP
cord-284409-xiyeceib	106	8	repertoire	repertoire	NN
cord-284409-xiyeceib	106	9	may	may	MD
cord-284409-xiyeceib	106	10	be	be	VB
cord-284409-xiyeceib	106	11	advantageous	advantageous	JJ
cord-284409-xiyeceib	106	12	for	for	IN
cord-284409-xiyeceib	106	13	the	the	DT
cord-284409-xiyeceib	106	14	exploration	exploration	NN
cord-284409-xiyeceib	106	15	of	of	IN
cord-284409-xiyeceib	106	16	the	the	DT
cord-284409-xiyeceib	106	17	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	106	18	-	-	HYPH
cord-284409-xiyeceib	106	19	2	2	CD
cord-284409-xiyeceib	106	20	*	*	NFP
cord-284409-xiyeceib	106	21	02	02	CD
cord-284409-xiyeceib	106	22	lineages	lineage	NNS
cord-284409-xiyeceib	106	23	when	when	WRB
cord-284409-xiyeceib	106	24	studying	study	VBG
cord-284409-xiyeceib	106	25	germline	germline	JJ
cord-284409-xiyeceib	106	26	precursors	precursor	NNS
cord-284409-xiyeceib	106	27	and	and	CC
cord-284409-xiyeceib	106	28	intermediates	intermediate	NNS
cord-284409-xiyeceib	106	29	of	of	IN
cord-284409-xiyeceib	106	30	VRC01	VRC01	NNP
cord-284409-xiyeceib	106	31	heavy	heavy	JJ
cord-284409-xiyeceib	106	32	chain	chain	NN
cord-284409-xiyeceib	106	33	.	.	.
cord-284409-xiyeceib	107	1	A	a	DT
cord-284409-xiyeceib	107	2	total	total	NN
cord-284409-xiyeceib	107	3	of	of	IN
cord-284409-xiyeceib	107	4	5,624	5,624	CD
cord-284409-xiyeceib	107	5	heavy	heavy	JJ
cord-284409-xiyeceib	107	6	chain	chain	NN
cord-284409-xiyeceib	107	7	and	and	CC
cord-284409-xiyeceib	107	8	1,096	1,096	CD
cord-284409-xiyeceib	107	9	light	light	JJ
cord-284409-xiyeceib	107	10	chain	chain	NN
cord-284409-xiyeceib	107	11	sequences	sequence	NNS
cord-284409-xiyeceib	107	12	of	of	IN
cord-284409-xiyeceib	107	13	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	107	14	-	-	SYM
cord-284409-xiyeceib	107	15	2	2	CD
cord-284409-xiyeceib	107	16	and	and	CC
cord-284409-xiyeceib	107	17	IGKV3	igkv3	CD
cord-284409-xiyeceib	107	18	-	-	HYPH
cord-284409-xiyeceib	107	19	11	11	CD
cord-284409-xiyeceib	107	20	lineages	lineage	NNS
cord-284409-xiyeceib	107	21	,	,	,
cord-284409-xiyeceib	107	22	respectively	respectively	RB
cord-284409-xiyeceib	107	23	,	,	,
cord-284409-xiyeceib	107	24	were	be	VBD
cord-284409-xiyeceib	107	25	used	use	VBN
cord-284409-xiyeceib	107	26	to	to	IN
cord-284409-xiyeceib	107	27	Frontiers	Frontiers	NNP
cord-284409-xiyeceib	107	28	in	in	IN
cord-284409-xiyeceib	107	29	Immunology	Immunology	NNP
cord-284409-xiyeceib	107	30	|	|	NNP
cord-284409-xiyeceib	107	31	HIV	HIV	NNP
cord-284409-xiyeceib	107	32	and	and	CC
cord-284409-xiyeceib	107	33	AIDS	AIDS	NNP
cord-284409-xiyeceib	107	34	select	select	VBP
cord-284409-xiyeceib	107	35	the	the	DT
cord-284409-xiyeceib	107	36	top	top	JJ
cord-284409-xiyeceib	107	37	10	10	CD
cord-284409-xiyeceib	107	38	sequences	sequence	NNS
cord-284409-xiyeceib	107	39	as	as	IN
cord-284409-xiyeceib	107	40	closest	close	JJS
cord-284409-xiyeceib	107	41	intermediates	intermediate	NNS
cord-284409-xiyeceib	107	42	for	for	IN
cord-284409-xiyeceib	107	43	VRC01	VRC01	NNP
cord-284409-xiyeceib	107	44	in	in	IN
cord-284409-xiyeceib	107	45	each	each	DT
cord-284409-xiyeceib	107	46	heavy	heavy	JJ
cord-284409-xiyeceib	107	47	and	and	CC
cord-284409-xiyeceib	107	48	light	light	JJ
cord-284409-xiyeceib	107	49	chain	chain	NN
cord-284409-xiyeceib	107	50	categories	category	NNS
cord-284409-xiyeceib	107	51	by	by	IN
cord-284409-xiyeceib	107	52	using	use	VBG
cord-284409-xiyeceib	107	53	local	local	JJ
cord-284409-xiyeceib	107	54	BLAST	blast	NN
cord-284409-xiyeceib	107	55	searching	search	VBG
cord-284409-xiyeceib	107	56	.	.	.
cord-284409-xiyeceib	108	1	We	-PRON-	PRP
cord-284409-xiyeceib	108	2	performed	perform	VBD
cord-284409-xiyeceib	108	3	phylogenetic	phylogenetic	JJ
cord-284409-xiyeceib	108	4	analysis	analysis	NN
cord-284409-xiyeceib	108	5	of	of	IN
cord-284409-xiyeceib	108	6	the	the	DT
cord-284409-xiyeceib	108	7	selected	select	VBN
cord-284409-xiyeceib	108	8	sequences	sequence	NNS
cord-284409-xiyeceib	108	9	to	to	TO
cord-284409-xiyeceib	108	10	identify	identify	VB
cord-284409-xiyeceib	108	11	genetic	genetic	JJ
cord-284409-xiyeceib	108	12	relationships	relationship	NNS
cord-284409-xiyeceib	108	13	among	among	IN
cord-284409-xiyeceib	108	14	VRC01-like	vrc01-like	NN
cord-284409-xiyeceib	108	15	intermediates	intermediate	NNS
cord-284409-xiyeceib	108	16	of	of	IN
cord-284409-xiyeceib	108	17	heavy	heavy	JJ
cord-284409-xiyeceib	108	18	(	(	-LRB-
cord-284409-xiyeceib	108	19	Figure	figure	NN
cord-284409-xiyeceib	108	20	2A	2a	CD
cord-284409-xiyeceib	108	21	)	)	-RRB-
cord-284409-xiyeceib	108	22	and	and	CC
cord-284409-xiyeceib	108	23	light	light	NN
cord-284409-xiyeceib	108	24	(	(	-LRB-
cord-284409-xiyeceib	108	25	Figure	figure	NN
cord-284409-xiyeceib	108	26	2B	2b	CD
cord-284409-xiyeceib	108	27	)	)	-RRB-
cord-284409-xiyeceib	108	28	chains	chain	NNS
cord-284409-xiyeceib	108	29	.	.	.
cord-284409-xiyeceib	109	1	We	-PRON-	PRP
cord-284409-xiyeceib	109	2	found	find	VBD
cord-284409-xiyeceib	109	3	two	two	CD
cord-284409-xiyeceib	109	4	of	of	IN
cord-284409-xiyeceib	109	5	the	the	DT
cord-284409-xiyeceib	109	6	antibody	antibody	NN
cord-284409-xiyeceib	109	7	heavy	heavy	JJ
cord-284409-xiyeceib	109	8	chains	chain	NNS
cord-284409-xiyeceib	109	9	,	,	,
cord-284409-xiyeceib	109	10	HWAV6	HWAV6	NNP
cord-284409-xiyeceib	109	11	and	and	CC
cord-284409-xiyeceib	109	12	JHEDT	JHEDT	NNP
cord-284409-xiyeceib	109	13	,	,	,
cord-284409-xiyeceib	109	14	which	which	WDT
cord-284409-xiyeceib	109	15	were	be	VBD
cord-284409-xiyeceib	109	16	100	100	CD
cord-284409-xiyeceib	109	17	%	%	NN
cord-284409-xiyeceib	109	18	identical	identical	JJ
cord-284409-xiyeceib	109	19	to	to	IN
cord-284409-xiyeceib	109	20	the	the	DT
cord-284409-xiyeceib	109	21	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	109	22	-	-	SYM
cord-284409-xiyeceib	109	23	2	2	CD
cord-284409-xiyeceib	109	24	*	*	NFP
cord-284409-xiyeceib	109	25	02	02	CD
cord-284409-xiyeceib	109	26	germline	germline	NN
cord-284409-xiyeceib	109	27	sequence	sequence	NN
cord-284409-xiyeceib	109	28	.	.	.
cord-284409-xiyeceib	110	1	Remarkably	remarkably	RB
cord-284409-xiyeceib	110	2	,	,	,
cord-284409-xiyeceib	110	3	their	-PRON-	PRP$
cord-284409-xiyeceib	110	4	CDRH3	cdrh3	NN
cord-284409-xiyeceib	110	5	sequences	sequence	NNS
cord-284409-xiyeceib	110	6	had	have	VBD
cord-284409-xiyeceib	110	7	the	the	DT
cord-284409-xiyeceib	110	8	same	same	JJ
cord-284409-xiyeceib	110	9	length	length	NN
cord-284409-xiyeceib	110	10	(	(	-LRB-
cord-284409-xiyeceib	110	11	14	14	CD
cord-284409-xiyeceib	110	12	amino	amino	JJ
cord-284409-xiyeceib	110	13	acids	acid	NNS
cord-284409-xiyeceib	110	14	)	)	-RRB-
cord-284409-xiyeceib	110	15	as	as	IN
cord-284409-xiyeceib	110	16	that	that	DT
cord-284409-xiyeceib	110	17	of	of	IN
cord-284409-xiyeceib	110	18	the	the	DT
cord-284409-xiyeceib	110	19	VRC01	VRC01	NNP
cord-284409-xiyeceib	110	20	heavy	heavy	JJ
cord-284409-xiyeceib	110	21	chain	chain	NN
cord-284409-xiyeceib	110	22	.	.	.
cord-284409-xiyeceib	111	1	For	for	IN
cord-284409-xiyeceib	111	2	these	these	DT
cord-284409-xiyeceib	111	3	10	10	CD
cord-284409-xiyeceib	111	4	heavy	heavy	JJ
cord-284409-xiyeceib	111	5	chain	chain	NN
cord-284409-xiyeceib	111	6	sequences	sequence	NNS
cord-284409-xiyeceib	111	7	,	,	,
cord-284409-xiyeceib	111	8	the	the	DT
cord-284409-xiyeceib	111	9	CDRH3	cdrh3	NN
cord-284409-xiyeceib	111	10	lengths	length	NNS
cord-284409-xiyeceib	111	11	ranged	range	VBD
cord-284409-xiyeceib	111	12	from	from	IN
cord-284409-xiyeceib	111	13	8	8	CD
cord-284409-xiyeceib	111	14	to	to	TO
cord-284409-xiyeceib	111	15	16	16	CD
cord-284409-xiyeceib	111	16	amino	amino	JJ
cord-284409-xiyeceib	111	17	acids	acid	NNS
cord-284409-xiyeceib	111	18	with	with	IN
cord-284409-xiyeceib	111	19	sequence	sequence	NN
cord-284409-xiyeceib	111	20	variations	variation	NNS
cord-284409-xiyeceib	111	21	at	at	IN
cord-284409-xiyeceib	111	22	the	the	DT
cord-284409-xiyeceib	111	23	junctions	junction	NNS
cord-284409-xiyeceib	111	24	.	.	.
cord-284409-xiyeceib	112	1	One	one	CD
cord-284409-xiyeceib	112	2	of	of	IN
cord-284409-xiyeceib	112	3	the	the	DT
cord-284409-xiyeceib	112	4	germline	germline	NN
cord-284409-xiyeceib	112	5	sequences	sequence	NNS
cord-284409-xiyeceib	112	6	,	,	,
cord-284409-xiyeceib	112	7	JHEDT	JHEDT	NNP
cord-284409-xiyeceib	112	8	,	,	,
cord-284409-xiyeceib	112	9	had	have	VBD
cord-284409-xiyeceib	112	10	a	a	DT
cord-284409-xiyeceib	112	11	point	point	NN
cord-284409-xiyeceib	112	12	mutation	mutation	NN
cord-284409-xiyeceib	112	13	at	at	IN
cord-284409-xiyeceib	112	14	Cys100Tyr	Cys100Tyr	NNP
cord-284409-xiyeceib	112	15	(	(	-LRB-
cord-284409-xiyeceib	112	16	Kabat	Kabat	NNP
cord-284409-xiyeceib	112	17	numbering	numbering	NN
cord-284409-xiyeceib	112	18	)	)	-RRB-
cord-284409-xiyeceib	112	19	of	of	IN
cord-284409-xiyeceib	112	20	CDRH3	cdrh3	NN
cord-284409-xiyeceib	112	21	that	that	WDT
cord-284409-xiyeceib	112	22	exactly	exactly	RB
cord-284409-xiyeceib	112	23	mimicked	mimic	VBD
cord-284409-xiyeceib	112	24	the	the	DT
cord-284409-xiyeceib	112	25	residue	residue	NN
cord-284409-xiyeceib	112	26	Tyr100	Tyr100	NNS
cord-284409-xiyeceib	112	27	of	of	IN
cord-284409-xiyeceib	112	28	CDRH3	cdrh3	NN
cord-284409-xiyeceib	112	29	in	in	IN
cord-284409-xiyeceib	112	30	VRC01	VRC01	NNP
cord-284409-xiyeceib	112	31	.	.	.
cord-284409-xiyeceib	113	1	The	the	DT
cord-284409-xiyeceib	113	2	residue	residue	NN
cord-284409-xiyeceib	113	3	Tyr100	Tyr100	NFP
cord-284409-xiyeceib	113	4	at	at	IN
cord-284409-xiyeceib	113	5	CDRH3	cdrh3	NN
cord-284409-xiyeceib	113	6	of	of	IN
cord-284409-xiyeceib	113	7	VRC01	VRC01	NNP
cord-284409-xiyeceib	113	8	is	be	VBZ
cord-284409-xiyeceib	113	9	most	most	RBS
cord-284409-xiyeceib	113	10	likely	likely	RB
cord-284409-xiyeceib	113	11	contributed	contribute	VBN
cord-284409-xiyeceib	113	12	by	by	IN
cord-284409-xiyeceib	113	13	the	the	DT
cord-284409-xiyeceib	113	14	IGHD3	IGHD3	NNP
cord-284409-xiyeceib	113	15	-	-	HYPH
cord-284409-xiyeceib	113	16	16	16	CD
cord-284409-xiyeceib	113	17	*	*	NFP
cord-284409-xiyeceib	113	18	02	02	CD
cord-284409-xiyeceib	113	19	germline	germline	NN
cord-284409-xiyeceib	113	20	with	with	IN
cord-284409-xiyeceib	113	21	a	a	DT
cord-284409-xiyeceib	113	22	point	point	NN
cord-284409-xiyeceib	113	23	mutation	mutation	NN
cord-284409-xiyeceib	113	24	Cys100Tyr	cys100tyr	NN
cord-284409-xiyeceib	113	25	.	.	.
cord-284409-xiyeceib	114	1	The	the	DT
cord-284409-xiyeceib	114	2	other	other	JJ
cord-284409-xiyeceib	114	3	heavy	heavy	JJ
cord-284409-xiyeceib	114	4	chain	chain	NN
cord-284409-xiyeceib	114	5	sequence	sequence	NN
cord-284409-xiyeceib	114	6	I76AT	I76AT	NNP
cord-284409-xiyeceib	114	7	,	,	,
cord-284409-xiyeceib	114	8	which	which	WDT
cord-284409-xiyeceib	114	9	was	be	VBD
cord-284409-xiyeceib	114	10	the	the	DT
cord-284409-xiyeceib	114	11	closest	close	JJS
cord-284409-xiyeceib	114	12	to	to	IN
cord-284409-xiyeceib	114	13	VRC01	VRC01	NNP
cord-284409-xiyeceib	114	14	heavy	heavy	JJ
cord-284409-xiyeceib	114	15	chain	chain	NN
cord-284409-xiyeceib	114	16	,	,	,
cord-284409-xiyeceib	114	17	also	also	RB
cord-284409-xiyeceib	114	18	had	have	VBD
cord-284409-xiyeceib	114	19	the	the	DT
cord-284409-xiyeceib	114	20	same	same	JJ
cord-284409-xiyeceib	114	21	mutation	mutation	NN
cord-284409-xiyeceib	114	22	at	at	IN
cord-284409-xiyeceib	114	23	Cys100Tyr	Cys100Tyr	NNP
cord-284409-xiyeceib	114	24	.	.	.
cord-284409-xiyeceib	115	1	One	one	CD
cord-284409-xiyeceib	115	2	of	of	IN
cord-284409-xiyeceib	115	3	the	the	DT
cord-284409-xiyeceib	115	4	other	other	JJ
cord-284409-xiyeceib	115	5	germline	germline	NN
cord-284409-xiyeceib	115	6	sequences	sequence	NNS
cord-284409-xiyeceib	115	7	,	,	,
cord-284409-xiyeceib	115	8	HWAV6	HWAV6	NNP
cord-284409-xiyeceib	115	9	,	,	,
cord-284409-xiyeceib	115	10	had	have	VBD
cord-284409-xiyeceib	115	11	Trp100B	Trp100B	VBN
cord-284409-xiyeceib	115	12	(	(	-LRB-
cord-284409-xiyeceib	115	13	Kabat	Kabat	NNP
cord-284409-xiyeceib	115	14	numbering	numbering	NN
cord-284409-xiyeceib	115	15	)	)	-RRB-
cord-284409-xiyeceib	115	16	of	of	IN
cord-284409-xiyeceib	115	17	CDRH3	cdrh3	NN
cord-284409-xiyeceib	115	18	that	that	WDT
cord-284409-xiyeceib	115	19	exactly	exactly	RB
cord-284409-xiyeceib	115	20	mimicked	mimic	VBD
cord-284409-xiyeceib	115	21	the	the	DT
cord-284409-xiyeceib	115	22	residue	residue	NN
cord-284409-xiyeceib	115	23	Trp100B	trp100b	NN
cord-284409-xiyeceib	115	24	of	of	IN
cord-284409-xiyeceib	115	25	CDRH3	cdrh3	NN
cord-284409-xiyeceib	115	26	in	in	IN
cord-284409-xiyeceib	115	27	VRC01	VRC01	NNP
cord-284409-xiyeceib	115	28	.	.	.
cord-284409-xiyeceib	116	1	Intriguingly	intriguingly	RB
cord-284409-xiyeceib	116	2	,	,	,
cord-284409-xiyeceib	116	3	the	the	DT
cord-284409-xiyeceib	116	4	Trp100B	trp100b	NN
cord-284409-xiyeceib	116	5	residue	residue	NN
cord-284409-xiyeceib	116	6	is	be	VBZ
cord-284409-xiyeceib	116	7	a	a	DT
cord-284409-xiyeceib	116	8	junctional	junctional	JJ
cord-284409-xiyeceib	116	9	amino	amino	NN
cord-284409-xiyeceib	116	10	acid	acid	NN
cord-284409-xiyeceib	116	11	of	of	IN
cord-284409-xiyeceib	116	12	the	the	DT
cord-284409-xiyeceib	116	13	CDRH3	cdrh3	NN
cord-284409-xiyeceib	116	14	in	in	IN
cord-284409-xiyeceib	116	15	germline	germline	JJ
cord-284409-xiyeceib	116	16	HWAV6	HWAV6	NNS
cord-284409-xiyeceib	116	17	,	,	,
cord-284409-xiyeceib	116	18	and	and	CC
cord-284409-xiyeceib	116	19	it	-PRON-	PRP
cord-284409-xiyeceib	116	20	exactly	exactly	RB
cord-284409-xiyeceib	116	21	replicates	replicate	VBZ
cord-284409-xiyeceib	116	22	the	the	DT
cord-284409-xiyeceib	116	23	Trp100B	trp100b	NN
cord-284409-xiyeceib	116	24	junctional	junctional	JJ
cord-284409-xiyeceib	116	25	residue	residue	NN
cord-284409-xiyeceib	116	26	of	of	IN
cord-284409-xiyeceib	116	27	CDRH3	cdrh3	NN
cord-284409-xiyeceib	116	28	in	in	IN
cord-284409-xiyeceib	116	29	VRC01	VRC01	NNP
cord-284409-xiyeceib	116	30	.	.	.
cord-284409-xiyeceib	117	1	This	this	DT
cord-284409-xiyeceib	117	2	suggests	suggest	VBZ
cord-284409-xiyeceib	117	3	a	a	DT
cord-284409-xiyeceib	117	4	possible	possible	JJ
cord-284409-xiyeceib	117	5	maturation	maturation	NN
cord-284409-xiyeceib	117	6	mechanism	mechanism	NN
cord-284409-xiyeceib	117	7	involved	involve	VBN
cord-284409-xiyeceib	117	8	in	in	IN
cord-284409-xiyeceib	117	9	the	the	DT
cord-284409-xiyeceib	117	10	VRC01-like	vrc01-like	NN
cord-284409-xiyeceib	117	11	intermediates	intermediate	NNS
cord-284409-xiyeceib	117	12	where	where	WRB
cord-284409-xiyeceib	117	13	junctional	junctional	JJ
cord-284409-xiyeceib	117	14	amino	amino	NN
cord-284409-xiyeceib	117	15	acids	acid	NNS
cord-284409-xiyeceib	117	16	could	could	MD
cord-284409-xiyeceib	117	17	determine	determine	VB
cord-284409-xiyeceib	117	18	the	the	DT
cord-284409-xiyeceib	117	19	maturation	maturation	NN
cord-284409-xiyeceib	117	20	pathway	pathway	NN
cord-284409-xiyeceib	117	21	far	far	RB
cord-284409-xiyeceib	117	22	preceding	precede	VBG
cord-284409-xiyeceib	117	23	the	the	DT
cord-284409-xiyeceib	117	24	somatic	somatic	JJ
cord-284409-xiyeceib	117	25	hypermutation	hypermutation	NN
cord-284409-xiyeceib	117	26	required	require	VBN
cord-284409-xiyeceib	117	27	for	for	IN
cord-284409-xiyeceib	117	28	affinity	affinity	NN
cord-284409-xiyeceib	117	29	maturation	maturation	NN
cord-284409-xiyeceib	117	30	(	(	-LRB-
cord-284409-xiyeceib	117	31	41	41	CD
cord-284409-xiyeceib	117	32	)	)	-RRB-
cord-284409-xiyeceib	117	33	.	.	.
cord-284409-xiyeceib	118	1	Most	Most	JJS
cord-284409-xiyeceib	118	2	of	of	IN
cord-284409-xiyeceib	118	3	the	the	DT
cord-284409-xiyeceib	118	4	closest	close	JJS
cord-284409-xiyeceib	118	5	IGHV	IGHV	NNP
cord-284409-xiyeceib	118	6	genes	gene	NNS
cord-284409-xiyeceib	118	7	,	,	,
cord-284409-xiyeceib	118	8	8	8	CD
cord-284409-xiyeceib	118	9	out	out	IN
cord-284409-xiyeceib	118	10	of	of	IN
cord-284409-xiyeceib	118	11	10	10	CD
cord-284409-xiyeceib	118	12	shown	show	VBN
cord-284409-xiyeceib	118	13	in	in	IN
cord-284409-xiyeceib	118	14	the	the	DT
cord-284409-xiyeceib	118	15	Figure	figure	NN
cord-284409-xiyeceib	118	16	2A	2a	NN
cord-284409-xiyeceib	118	17	,	,	,
cord-284409-xiyeceib	118	18	have	have	VBP
cord-284409-xiyeceib	118	19	at	at	RB
cord-284409-xiyeceib	118	20	least	least	RBS
cord-284409-xiyeceib	118	21	one	one	CD
cord-284409-xiyeceib	118	22	mutation	mutation	NN
cord-284409-xiyeceib	118	23	in	in	IN
cord-284409-xiyeceib	118	24	the	the	DT
cord-284409-xiyeceib	118	25	V	v	NN
cord-284409-xiyeceib	118	26	region	region	NN
cord-284409-xiyeceib	118	27	,	,	,
cord-284409-xiyeceib	118	28	and	and	CC
cord-284409-xiyeceib	118	29	www.frontiersin.org	www.frontiersin.org	IN
cord-284409-xiyeceib	118	30	two	two	CD
cord-284409-xiyeceib	118	31	sequences	sequence	NNS
cord-284409-xiyeceib	118	32	,	,	,
cord-284409-xiyeceib	118	33	G2W0	G2W0	NNP
cord-284409-xiyeceib	118	34	T	T	NNP
cord-284409-xiyeceib	118	35	and	and	CC
cord-284409-xiyeceib	118	36	GD60C	gd60c	NN
cord-284409-xiyeceib	118	37	,	,	,
cord-284409-xiyeceib	118	38	have	have	VBP
cord-284409-xiyeceib	118	39	two	two	CD
cord-284409-xiyeceib	118	40	mutations	mutation	NNS
cord-284409-xiyeceib	118	41	at	at	IN
cord-284409-xiyeceib	118	42	each	each	DT
cord-284409-xiyeceib	118	43	of	of	IN
cord-284409-xiyeceib	118	44	the	the	DT
cord-284409-xiyeceib	118	45	CDRH1	cdrh1	NN
cord-284409-xiyeceib	118	46	.	.	.
cord-284409-xiyeceib	119	1	The	the	DT
cord-284409-xiyeceib	119	2	pre	pre	JJ
cord-284409-xiyeceib	119	3	-	-	JJ
cord-284409-xiyeceib	119	4	existing	existing	JJ
cord-284409-xiyeceib	119	5	amino	amino	NN
cord-284409-xiyeceib	119	6	acid	acid	NN
cord-284409-xiyeceib	119	7	mutations	mutation	NNS
cord-284409-xiyeceib	119	8	found	find	VBN
cord-284409-xiyeceib	119	9	in	in	IN
cord-284409-xiyeceib	119	10	the	the	DT
cord-284409-xiyeceib	119	11	V	v	NN
cord-284409-xiyeceib	119	12	region	region	NN
cord-284409-xiyeceib	119	13	and	and	CC
cord-284409-xiyeceib	119	14	CDRH3	cdrh3	NN
cord-284409-xiyeceib	119	15	sequence	sequence	NN
cord-284409-xiyeceib	119	16	information	information	NN
cord-284409-xiyeceib	119	17	may	may	MD
cord-284409-xiyeceib	119	18	inform	inform	VB
cord-284409-xiyeceib	119	19	the	the	DT
cord-284409-xiyeceib	119	20	design	design	NN
cord-284409-xiyeceib	119	21	of	of	IN
cord-284409-xiyeceib	119	22	heavy	heavy	JJ
cord-284409-xiyeceib	119	23	chain	chain	NN
cord-284409-xiyeceib	119	24	germline	germline	NN
cord-284409-xiyeceib	119	25	-	-	HYPH
cord-284409-xiyeceib	119	26	like	like	JJ
cord-284409-xiyeceib	119	27	precursors	precursor	NNS
cord-284409-xiyeceib	119	28	and	and	CC
cord-284409-xiyeceib	119	29	intermediates	intermediate	NNS
cord-284409-xiyeceib	119	30	,	,	,
cord-284409-xiyeceib	119	31	and	and	CC
cord-284409-xiyeceib	119	32	help	help	VBP
cord-284409-xiyeceib	119	33	naturally	naturally	RB
cord-284409-xiyeceib	119	34	reconstruct	reconstruct	VB
cord-284409-xiyeceib	119	35	the	the	DT
cord-284409-xiyeceib	119	36	B	b	NN
cord-284409-xiyeceib	119	37	cell	cell	NN
cord-284409-xiyeceib	119	38	clonal	clonal	JJ
cord-284409-xiyeceib	119	39	lineages	lineage	NNS
cord-284409-xiyeceib	119	40	in	in	IN
cord-284409-xiyeceib	119	41	the	the	DT
cord-284409-xiyeceib	119	42	maturation	maturation	NN
cord-284409-xiyeceib	119	43	pathways	pathway	NNS
cord-284409-xiyeceib	119	44	of	of	IN
cord-284409-xiyeceib	119	45	VRC01	VRC01	NNP
cord-284409-xiyeceib	119	46	.	.	.
cord-284409-xiyeceib	120	1	Light	light	JJ
cord-284409-xiyeceib	120	2	chain	chain	NN
cord-284409-xiyeceib	120	3	recognition	recognition	NN
cord-284409-xiyeceib	120	4	of	of	IN
cord-284409-xiyeceib	120	5	Envs	Envs	NNP
cord-284409-xiyeceib	120	6	by	by	IN
cord-284409-xiyeceib	120	7	VRC01	VRC01	NNP
cord-284409-xiyeceib	120	8	and	and	CC
cord-284409-xiyeceib	120	9	VRC01-related	VRC01-related	NNP
cord-284409-xiyeceib	120	10	antibodies	antibody	NNS
cord-284409-xiyeceib	120	11	has	have	VBZ
cord-284409-xiyeceib	120	12	been	be	VBN
cord-284409-xiyeceib	120	13	studied	study	VBN
cord-284409-xiyeceib	120	14	in	in	IN
cord-284409-xiyeceib	120	15	detail	detail	NN
cord-284409-xiyeceib	120	16	using	use	VBG
cord-284409-xiyeceib	120	17	structural	structural	JJ
cord-284409-xiyeceib	120	18	and	and	CC
cord-284409-xiyeceib	120	19	454	454	CD
cord-284409-xiyeceib	120	20	sequencing	sequencing	NN
cord-284409-xiyeceib	120	21	data	datum	NNS
cord-284409-xiyeceib	120	22	(	(	-LRB-
cord-284409-xiyeceib	120	23	33	33	CD
cord-284409-xiyeceib	120	24	)	)	-RRB-
cord-284409-xiyeceib	120	25	.	.	.
cord-284409-xiyeceib	121	1	The	the	DT
cord-284409-xiyeceib	121	2	VRC01	VRC01	NNP
cord-284409-xiyeceib	121	3	light	light	JJ
cord-284409-xiyeceib	121	4	chain	chain	NN
cord-284409-xiyeceib	121	5	commonly	commonly	RB
cord-284409-xiyeceib	121	6	uses	use	VBZ
cord-284409-xiyeceib	121	7	the	the	DT
cord-284409-xiyeceib	121	8	IGKV1	IGKV1	NNP
cord-284409-xiyeceib	121	9	-	-	HYPH
cord-284409-xiyeceib	121	10	33	33	CD
cord-284409-xiyeceib	121	11	lineage	lineage	NN
cord-284409-xiyeceib	121	12	and	and	CC
cord-284409-xiyeceib	121	13	has	have	VBZ
cord-284409-xiyeceib	121	14	a	a	DT
cord-284409-xiyeceib	121	15	characteristic	characteristic	JJ
cord-284409-xiyeceib	121	16	five	five	CD
cord-284409-xiyeceib	121	17	amino	amino	NN
cord-284409-xiyeceib	121	18	acid	acid	NN
cord-284409-xiyeceib	121	19	long	long	RB
cord-284409-xiyeceib	121	20	CDRL3	cdrl3	NN
cord-284409-xiyeceib	121	21	and	and	CC
cord-284409-xiyeceib	121	22	a	a	DT
cord-284409-xiyeceib	121	23	distinctive	distinctive	JJ
cord-284409-xiyeceib	121	24	two	two	CD
cord-284409-xiyeceib	121	25	amino	amino	NN
cord-284409-xiyeceib	121	26	acid	acid	NN
cord-284409-xiyeceib	121	27	deletion	deletion	NN
cord-284409-xiyeceib	121	28	in	in	IN
cord-284409-xiyeceib	121	29	CDR	CDR	NNP
cord-284409-xiyeceib	121	30	L1	L1	NNP
cord-284409-xiyeceib	121	31	.	.	.
cord-284409-xiyeceib	122	1	Therefore	therefore	RB
cord-284409-xiyeceib	122	2	,	,	,
cord-284409-xiyeceib	122	3	we	-PRON-	PRP
cord-284409-xiyeceib	122	4	selected	select	VBD
cord-284409-xiyeceib	122	5	the	the	DT
cord-284409-xiyeceib	122	6	IGKV1	IGKV1	NNP
cord-284409-xiyeceib	122	7	-	-	HYPH
cord-284409-xiyeceib	122	8	33	33	CD
cord-284409-xiyeceib	122	9	lineage	lineage	NN
cord-284409-xiyeceib	122	10	sequences	sequence	NNS
cord-284409-xiyeceib	122	11	with	with	IN
cord-284409-xiyeceib	122	12	five	five	CD
cord-284409-xiyeceib	122	13	amino	amino	NN
cord-284409-xiyeceib	122	14	acid	acid	NN
cord-284409-xiyeceib	122	15	length	length	NN
cord-284409-xiyeceib	123	1	CDRL3s	cdrl3s	RB
cord-284409-xiyeceib	123	2	,	,	,
cord-284409-xiyeceib	123	3	but	but	CC
cord-284409-xiyeceib	123	4	no	no	DT
cord-284409-xiyeceib	123	5	sequences	sequence	NNS
cord-284409-xiyeceib	123	6	were	be	VBD
cord-284409-xiyeceib	123	7	found	find	VBN
cord-284409-xiyeceib	123	8	with	with	IN
cord-284409-xiyeceib	123	9	a	a	DT
cord-284409-xiyeceib	123	10	two	two	CD
cord-284409-xiyeceib	123	11	amino	amino	NN
cord-284409-xiyeceib	123	12	acid	acid	NN
cord-284409-xiyeceib	123	13	deletion	deletion	NN
cord-284409-xiyeceib	123	14	in	in	IN
cord-284409-xiyeceib	123	15	CDR	CDR	NNP
cord-284409-xiyeceib	123	16	L1	L1	NNP
cord-284409-xiyeceib	123	17	(	(	-LRB-
cord-284409-xiyeceib	123	18	Figure	figure	NN
cord-284409-xiyeceib	123	19	2B	2b	CD
cord-284409-xiyeceib	123	20	)	)	-RRB-
cord-284409-xiyeceib	123	21	.	.	.
cord-284409-xiyeceib	124	1	All	all	DT
cord-284409-xiyeceib	124	2	of	of	IN
cord-284409-xiyeceib	124	3	them	-PRON-	PRP
cord-284409-xiyeceib	124	4	had	have	VBD
cord-284409-xiyeceib	124	5	either	either	CC
cord-284409-xiyeceib	124	6	framework	framework	NN
cord-284409-xiyeceib	124	7	or	or	CC
cord-284409-xiyeceib	124	8	CDR	cdr	NN
cord-284409-xiyeceib	124	9	mutations	mutation	NNS
cord-284409-xiyeceib	124	10	or	or	CC
cord-284409-xiyeceib	124	11	both	both	DT
cord-284409-xiyeceib	124	12	.	.	.
cord-284409-xiyeceib	125	1	Four	four	CD
cord-284409-xiyeceib	125	2	of	of	IN
cord-284409-xiyeceib	125	3	them	-PRON-	PRP
cord-284409-xiyeceib	125	4	had	have	VBD
cord-284409-xiyeceib	125	5	a	a	DT
cord-284409-xiyeceib	125	6	point	point	NN
cord-284409-xiyeceib	125	7	mutation	mutation	NN
cord-284409-xiyeceib	125	8	at	at	IN
cord-284409-xiyeceib	125	9	CDRL1	CDRL1	NNS
cord-284409-xiyeceib	125	10	and	and	CC
cord-284409-xiyeceib	125	11	seven	seven	CD
cord-284409-xiyeceib	125	12	of	of	IN
cord-284409-xiyeceib	125	13	them	-PRON-	PRP
cord-284409-xiyeceib	125	14	had	have	VBD
cord-284409-xiyeceib	125	15	a	a	DT
cord-284409-xiyeceib	125	16	point	point	NN
cord-284409-xiyeceib	125	17	mutation	mutation	NN
cord-284409-xiyeceib	125	18	at	at	IN
cord-284409-xiyeceib	125	19	CDRL3	CDRL3	NNP
cord-284409-xiyeceib	125	20	.	.	.
cord-284409-xiyeceib	126	1	The	the	DT
cord-284409-xiyeceib	126	2	structural	structural	JJ
cord-284409-xiyeceib	126	3	basis	basis	NN
cord-284409-xiyeceib	126	4	for	for	IN
cord-284409-xiyeceib	126	5	germline	germline	JJ
cord-284409-xiyeceib	126	6	gene	gene	NN
cord-284409-xiyeceib	126	7	usage	usage	NN
cord-284409-xiyeceib	126	8	of	of	IN
cord-284409-xiyeceib	126	9	VRC01-related	VRC01-related	NNP
cord-284409-xiyeceib	126	10	antibodies	antibody	NNS
cord-284409-xiyeceib	126	11	targeting	target	VBG
cord-284409-xiyeceib	126	12	the	the	DT
cord-284409-xiyeceib	126	13	CD4bs	CD4bs	NNP
cord-284409-xiyeceib	126	14	has	have	VBZ
cord-284409-xiyeceib	126	15	been	be	VBN
cord-284409-xiyeceib	126	16	previously	previously	RB
cord-284409-xiyeceib	126	17	described	describe	VBN
cord-284409-xiyeceib	126	18	(	(	-LRB-
cord-284409-xiyeceib	126	19	42	42	CD
cord-284409-xiyeceib	126	20	)	)	-RRB-
cord-284409-xiyeceib	126	21	,	,	,
cord-284409-xiyeceib	126	22	which	which	WDT
cord-284409-xiyeceib	126	23	revealed	reveal	VBD
cord-284409-xiyeceib	126	24	a	a	DT
cord-284409-xiyeceib	126	25	set	set	NN
cord-284409-xiyeceib	126	26	of	of	IN
cord-284409-xiyeceib	126	27	signature	signature	NN
cord-284409-xiyeceib	126	28	features	feature	NNS
cord-284409-xiyeceib	126	29	for	for	IN
cord-284409-xiyeceib	126	30	these	these	DT
cord-284409-xiyeceib	126	31	antibodies	antibody	NNS
cord-284409-xiyeceib	126	32	that	that	WDT
cord-284409-xiyeceib	126	33	were	be	VBD
cord-284409-xiyeceib	126	34	verified	verify	VBN
cord-284409-xiyeceib	126	35	by	by	IN
cord-284409-xiyeceib	126	36	mutagenesis	mutagenesis	NN
cord-284409-xiyeceib	126	37	.	.	.
cord-284409-xiyeceib	127	1	These	these	DT
cord-284409-xiyeceib	127	2	signature	signature	NN
cord-284409-xiyeceib	127	3	features	feature	NNS
cord-284409-xiyeceib	127	4	explained	explain	VBD
cord-284409-xiyeceib	127	5	the	the	DT
cord-284409-xiyeceib	127	6	origin	origin	NN
cord-284409-xiyeceib	127	7	of	of	IN
cord-284409-xiyeceib	127	8	the	the	DT
cord-284409-xiyeceib	127	9	IGVH1	IGVH1	NNP
cord-284409-xiyeceib	127	10	-	-	HYPH
cord-284409-xiyeceib	127	11	2	2	CD
cord-284409-xiyeceib	127	12	gene	gene	NN
cord-284409-xiyeceib	127	13	and	and	CC
cord-284409-xiyeceib	127	14	antibody	antibody	NN
cord-284409-xiyeceib	127	15	resistance	resistance	NN
cord-284409-xiyeceib	127	16	for	for	IN
cord-284409-xiyeceib	127	17	some	some	DT
cord-284409-xiyeceib	127	18	Env	Env	NNP
cord-284409-xiyeceib	127	19	sequences	sequence	NNS
cord-284409-xiyeceib	127	20	.	.	.
cord-284409-xiyeceib	128	1	We	-PRON-	PRP
cord-284409-xiyeceib	128	2	found	find	VBD
cord-284409-xiyeceib	128	3	that	that	IN
cord-284409-xiyeceib	128	4	characteristic	characteristic	JJ
cord-284409-xiyeceib	128	5	residues	residue	NNS
cord-284409-xiyeceib	128	6	including	include	VBG
cord-284409-xiyeceib	128	7	the	the	DT
cord-284409-xiyeceib	128	8	Trp100B	trp100b	NN
cord-284409-xiyeceib	128	9	of	of	IN
cord-284409-xiyeceib	128	10	heavy	heavy	JJ
cord-284409-xiyeceib	128	11	chains	chain	NNS
cord-284409-xiyeceib	128	12	were	be	VBD
cord-284409-xiyeceib	128	13	conserved	conserve	VBN
cord-284409-xiyeceib	128	14	while	while	IN
cord-284409-xiyeceib	128	15	light	light	JJ
cord-284409-xiyeceib	128	16	chains	chain	NNS
cord-284409-xiyeceib	128	17	did	do	VBD
cord-284409-xiyeceib	128	18	not	not	RB
cord-284409-xiyeceib	128	19	have	have	VB
cord-284409-xiyeceib	128	20	any	any	DT
cord-284409-xiyeceib	128	21	characteristic	characteristic	JJ
cord-284409-xiyeceib	128	22	residues	residue	NNS
cord-284409-xiyeceib	128	23	as	as	IN
cord-284409-xiyeceib	128	24	reported	report	VBN
cord-284409-xiyeceib	128	25	previously	previously	RB
cord-284409-xiyeceib	128	26	(	(	-LRB-
cord-284409-xiyeceib	128	27	42	42	CD
cord-284409-xiyeceib	128	28	)	)	-RRB-
cord-284409-xiyeceib	128	29	.	.	.
cord-284409-xiyeceib	129	1	However	however	RB
cord-284409-xiyeceib	129	2	,	,	,
cord-284409-xiyeceib	129	3	other	other	JJ
cord-284409-xiyeceib	129	4	pre	pre	JJ
cord-284409-xiyeceib	129	5	-	-	JJ
cord-284409-xiyeceib	129	6	existing	existing	JJ
cord-284409-xiyeceib	129	7	amino	amino	NN
cord-284409-xiyeceib	129	8	acid	acid	NN
cord-284409-xiyeceib	129	9	mutations	mutation	NNS
cord-284409-xiyeceib	129	10	in	in	IN
cord-284409-xiyeceib	129	11	light	light	JJ
cord-284409-xiyeceib	129	12	chains	chain	NNS
cord-284409-xiyeceib	129	13	could	could	MD
cord-284409-xiyeceib	129	14	have	have	VB
cord-284409-xiyeceib	129	15	implications	implication	NNS
cord-284409-xiyeceib	129	16	for	for	IN
cord-284409-xiyeceib	129	17	the	the	DT
cord-284409-xiyeceib	129	18	VRC01-related	VRC01-related	NNP
cord-284409-xiyeceib	129	19	intermediates	intermediate	NNS
cord-284409-xiyeceib	129	20	with	with	IN
cord-284409-xiyeceib	129	21	a	a	DT
cord-284409-xiyeceib	129	22	characteristic	characteristic	JJ
cord-284409-xiyeceib	129	23	CDRL3	cdrl3	NN
cord-284409-xiyeceib	129	24	of	of	IN
cord-284409-xiyeceib	129	25	five	five	CD
cord-284409-xiyeceib	129	26	amino	amino	NN
cord-284409-xiyeceib	129	27	acid	acid	NN
cord-284409-xiyeceib	129	28	length	length	NN
cord-284409-xiyeceib	129	29	.	.	.
cord-284409-xiyeceib	130	1	We	-PRON-	PRP
cord-284409-xiyeceib	130	2	analyzed	analyze	VBD
cord-284409-xiyeceib	130	3	the	the	DT
cord-284409-xiyeceib	130	4	amino	amino	NN
cord-284409-xiyeceib	130	5	acid	acid	NN
cord-284409-xiyeceib	130	6	length	length	NN
cord-284409-xiyeceib	130	7	distributions	distribution	NNS
cord-284409-xiyeceib	130	8	of	of	IN
cord-284409-xiyeceib	130	9	CDRH3	cdrh3	NN
cord-284409-xiyeceib	130	10	and	and	CC
cord-284409-xiyeceib	130	11	CDRL3	cdrl3	NN
cord-284409-xiyeceib	130	12	sequences	sequence	NNS
cord-284409-xiyeceib	130	13	that	that	WDT
cord-284409-xiyeceib	130	14	were	be	VBD
cord-284409-xiyeceib	130	15	of	of	IN
cord-284409-xiyeceib	130	16	VRC01	VRC01	NNP
cord-284409-xiyeceib	130	17	origins	origin	NNS
cord-284409-xiyeceib	130	18	,	,	,
cord-284409-xiyeceib	130	19	namely	namely	RB
cord-284409-xiyeceib	130	20	,	,	,
cord-284409-xiyeceib	130	21	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	130	22	-	-	HYPH
cord-284409-xiyeceib	130	23	2	2	CD
cord-284409-xiyeceib	130	24	and	and	CC
cord-284409-xiyeceib	130	25	IGKV3	igkv3	CD
cord-284409-xiyeceib	130	26	-	-	HYPH
cord-284409-xiyeceib	130	27	11	11	CD
cord-284409-xiyeceib	130	28	for	for	IN
cord-284409-xiyeceib	130	29	heavy	heavy	JJ
cord-284409-xiyeceib	130	30	and	and	CC
cord-284409-xiyeceib	130	31	light	light	JJ
cord-284409-xiyeceib	130	32	chains	chain	NNS
cord-284409-xiyeceib	130	33	,	,	,
cord-284409-xiyeceib	130	34	respectively	respectively	RB
cord-284409-xiyeceib	130	35	,	,	,
cord-284409-xiyeceib	130	36	as	as	IN
cord-284409-xiyeceib	130	37	derived	derive	VBN
cord-284409-xiyeceib	130	38	from	from	IN
cord-284409-xiyeceib	130	39	the	the	DT
cord-284409-xiyeceib	130	40	human	human	JJ
cord-284409-xiyeceib	130	41	cord	cord	NN
cord-284409-xiyeceib	130	42	blood	blood	NNP
cord-284409-xiyeceib	130	43	IgM	IgM	NNP
cord-284409-xiyeceib	130	44	library	library	NNP
cord-284409-xiyeceib	130	45	(	(	-LRB-
cord-284409-xiyeceib	130	46	Figure	Figure	NNP
cord-284409-xiyeceib	130	47	3	3	CD
cord-284409-xiyeceib	130	48	)	)	-RRB-
cord-284409-xiyeceib	130	49	.	.	.
cord-284409-xiyeceib	131	1	The	the	DT
cord-284409-xiyeceib	131	2	CDRH3	cdrh3	NN
cord-284409-xiyeceib	131	3	lengths	length	NNS
cord-284409-xiyeceib	131	4	ranged	range	VBD
cord-284409-xiyeceib	131	5	from	from	IN
cord-284409-xiyeceib	131	6	4	4	CD
cord-284409-xiyeceib	131	7	to	to	TO
cord-284409-xiyeceib	131	8	27	27	CD
cord-284409-xiyeceib	131	9	amino	amino	JJ
cord-284409-xiyeceib	131	10	acids	acid	NNS
cord-284409-xiyeceib	131	11	,	,	,
cord-284409-xiyeceib	131	12	indicating	indicate	VBG
cord-284409-xiyeceib	131	13	high	high	JJ
cord-284409-xiyeceib	131	14	CDR3	CDR3	NNP
cord-284409-xiyeceib	131	15	length	length	NN
cord-284409-xiyeceib	131	16	diversity	diversity	NN
cord-284409-xiyeceib	131	17	(	(	-LRB-
cord-284409-xiyeceib	131	18	Figure	figure	NN
cord-284409-xiyeceib	131	19	3A	3a	CD
cord-284409-xiyeceib	131	20	)	)	-RRB-
cord-284409-xiyeceib	131	21	.	.	.
cord-284409-xiyeceib	132	1	VRC01	VRC01	NNP
cord-284409-xiyeceib	132	2	has	have	VBZ
cord-284409-xiyeceib	132	3	a	a	DT
cord-284409-xiyeceib	132	4	CDRH3	cdrh3	NN
cord-284409-xiyeceib	132	5	length	length	NN
cord-284409-xiyeceib	132	6	of	of	IN
cord-284409-xiyeceib	132	7	14	14	CD
cord-284409-xiyeceib	132	8	amino	amino	JJ
cord-284409-xiyeceib	132	9	acids	acid	NNS
cord-284409-xiyeceib	132	10	,	,	,
cord-284409-xiyeceib	132	11	which	which	WDT
cord-284409-xiyeceib	132	12	is	be	VBZ
cord-284409-xiyeceib	132	13	shorter	short	JJR
cord-284409-xiyeceib	132	14	than	than	IN
cord-284409-xiyeceib	132	15	those	those	DT
cord-284409-xiyeceib	132	16	of	of	IN
cord-284409-xiyeceib	132	17	most	most	JJS
cord-284409-xiyeceib	132	18	other	other	JJ
cord-284409-xiyeceib	132	19	anti	anti	JJ
cord-284409-xiyeceib	132	20	-	-	JJ
cord-284409-xiyeceib	132	21	HIV-1	hiv-1	JJ
cord-284409-xiyeceib	132	22	antibodies	antibody	NNS
cord-284409-xiyeceib	132	23	(	(	-LRB-
cord-284409-xiyeceib	132	24	25	25	CD
cord-284409-xiyeceib	132	25	)	)	-RRB-
cord-284409-xiyeceib	132	26	.	.	.
cord-284409-xiyeceib	133	1	The	the	DT
cord-284409-xiyeceib	133	2	LCDR3	LCDR3	NNS
cord-284409-xiyeceib	133	3	lengths	length	NNS
cord-284409-xiyeceib	133	4	ranged	range	VBD
cord-284409-xiyeceib	133	5	from	from	IN
cord-284409-xiyeceib	133	6	4	4	CD
cord-284409-xiyeceib	133	7	to	to	TO
cord-284409-xiyeceib	133	8	14	14	CD
cord-284409-xiyeceib	133	9	amino	amino	JJ
cord-284409-xiyeceib	133	10	acids	acid	NNS
cord-284409-xiyeceib	133	11	(	(	-LRB-
cord-284409-xiyeceib	133	12	Figure	figure	NN
cord-284409-xiyeceib	133	13	3B	3b	CD
cord-284409-xiyeceib	133	14	)	)	-RRB-
cord-284409-xiyeceib	133	15	.	.	.
cord-284409-xiyeceib	134	1	The	the	DT
cord-284409-xiyeceib	134	2	CDRL3	cdrl3	NN
cord-284409-xiyeceib	134	3	of	of	IN
cord-284409-xiyeceib	134	4	VRC01	VRC01	NNP
cord-284409-xiyeceib	134	5	has	have	VBZ
cord-284409-xiyeceib	134	6	a	a	DT
cord-284409-xiyeceib	134	7	characteristic	characteristic	JJ
cord-284409-xiyeceib	134	8	length	length	NN
cord-284409-xiyeceib	134	9	of	of	IN
cord-284409-xiyeceib	134	10	five	five	CD
cord-284409-xiyeceib	134	11	amino	amino	NN
cord-284409-xiyeceib	134	12	acids	acid	NNS
cord-284409-xiyeceib	134	13	with	with	IN
cord-284409-xiyeceib	134	14	a	a	DT
cord-284409-xiyeceib	134	15	mature	mature	JJ
cord-284409-xiyeceib	134	16	genetic	genetic	JJ
cord-284409-xiyeceib	134	17	signature	signature	NN
cord-284409-xiyeceib	134	18	(	(	-LRB-
cord-284409-xiyeceib	134	19	33	33	CD
cord-284409-xiyeceib	134	20	)	)	-RRB-
cord-284409-xiyeceib	134	21	.	.	.
cord-284409-xiyeceib	135	1	Analysis	analysis	NN
cord-284409-xiyeceib	135	2	of	of	IN
cord-284409-xiyeceib	135	3	the	the	DT
cord-284409-xiyeceib	135	4	human	human	JJ
cord-284409-xiyeceib	135	5	cord	cord	NN
cord-284409-xiyeceib	135	6	blood	blood	NN
cord-284409-xiyeceib	135	7	IgM	IgM	NNP
cord-284409-xiyeceib	135	8	repertoire	repertoire	NN
cord-284409-xiyeceib	135	9	showed	show	VBD
cord-284409-xiyeceib	135	10	only	only	RB
cord-284409-xiyeceib	135	11	a	a	DT
cord-284409-xiyeceib	135	12	fraction	fraction	NN
cord-284409-xiyeceib	135	13	of	of	IN
cord-284409-xiyeceib	135	14	such	such	JJ
cord-284409-xiyeceib	135	15	light	light	JJ
cord-284409-xiyeceib	135	16	chains	chain	NNS
cord-284409-xiyeceib	135	17	with	with	IN
cord-284409-xiyeceib	135	18	a	a	DT
cord-284409-xiyeceib	135	19	shorter	short	JJR
cord-284409-xiyeceib	135	20	length	length	NN
cord-284409-xiyeceib	135	21	of	of	IN
cord-284409-xiyeceib	135	22	five	five	CD
cord-284409-xiyeceib	135	23	amino	amino	NN
cord-284409-xiyeceib	135	24	acids	acid	NNS
cord-284409-xiyeceib	135	25	(	(	-LRB-
cord-284409-xiyeceib	135	26	Figure	figure	NN
cord-284409-xiyeceib	135	27	3B	3b	CD
cord-284409-xiyeceib	135	28	)	)	-RRB-
cord-284409-xiyeceib	135	29	respectively	respectively	RB
cord-284409-xiyeceib	135	30	.	.	.
cord-284409-xiyeceib	136	1	These	these	DT
cord-284409-xiyeceib	136	2	plots	plot	NNS
cord-284409-xiyeceib	136	3	show	show	VBP
cord-284409-xiyeceib	136	4	that	that	IN
cord-284409-xiyeceib	136	5	there	there	EX
cord-284409-xiyeceib	136	6	are	be	VBP
cord-284409-xiyeceib	136	7	position	position	NN
cord-284409-xiyeceib	136	8	specific	specific	JJ
cord-284409-xiyeceib	136	9	variations	variation	NNS
cord-284409-xiyeceib	136	10	in	in	IN
cord-284409-xiyeceib	136	11	the	the	DT
cord-284409-xiyeceib	136	12	CDRH1	cdrh1	NN
cord-284409-xiyeceib	136	13	and	and	CC
cord-284409-xiyeceib	136	14	CDRH2	CDRH2	NNP
cord-284409-xiyeceib	136	15	regions	region	NNS
cord-284409-xiyeceib	136	16	of	of	IN
cord-284409-xiyeceib	136	17	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	136	18	-	-	HYPH
cord-284409-xiyeceib	136	19	2	2	CD
cord-284409-xiyeceib	136	20	genes	gene	NNS
cord-284409-xiyeceib	136	21	.	.	.
cord-284409-xiyeceib	137	1	These	these	DT
cord-284409-xiyeceib	137	2	could	could	MD
cord-284409-xiyeceib	137	3	indicate	indicate	VB
cord-284409-xiyeceib	137	4	possible	possible	JJ
cord-284409-xiyeceib	137	5	IGHV1	ighv1	NN
cord-284409-xiyeceib	137	6	-	-	HYPH
cord-284409-xiyeceib	137	7	2	2	CD
cord-284409-xiyeceib	137	8	specific	specific	JJ
cord-284409-xiyeceib	137	9	pre	pre	JJ
cord-284409-xiyeceib	137	10	-	-	JJ
cord-284409-xiyeceib	137	11	existing	existing	JJ
cord-284409-xiyeceib	137	12	amino	amino	NN
cord-284409-xiyeceib	137	13	acid	acid	NN
cord-284409-xiyeceib	137	14	mutations	mutation	NNS
cord-284409-xiyeceib	137	15	in	in	IN
cord-284409-xiyeceib	137	16	CDRH1	CDRH1	NNP
cord-284409-xiyeceib	137	17	and	and	CC
cord-284409-xiyeceib	137	18	CDRH2	CDRH2	NNP
cord-284409-xiyeceib	137	19	,	,	,
cord-284409-xiyeceib	137	20	as	as	IN
cord-284409-xiyeceib	137	21	observed	observe	VBN
cord-284409-xiyeceib	137	22	in	in	IN
cord-284409-xiyeceib	137	23	several	several	JJ
cord-284409-xiyeceib	137	24	naïve	naïve	JJ
cord-284409-xiyeceib	137	25	antibody	antibody	NN
cord-284409-xiyeceib	137	26	heavy	heavy	JJ
cord-284409-xiyeceib	137	27	chain	chain	NN
cord-284409-xiyeceib	137	28	sequences	sequence	NNS
cord-284409-xiyeceib	137	29	,	,	,
cord-284409-xiyeceib	137	30	which	which	WDT
cord-284409-xiyeceib	137	31	could	could	MD
cord-284409-xiyeceib	137	32	inform	inform	VB
cord-284409-xiyeceib	137	33	the	the	DT
cord-284409-xiyeceib	137	34	design	design	NN
cord-284409-xiyeceib	137	35	of	of	IN
cord-284409-xiyeceib	137	36	germline	germline	JJ
cord-284409-xiyeceib	137	37	precursors	precursor	NNS
cord-284409-xiyeceib	137	38	and	and	CC
cord-284409-xiyeceib	137	39	intermediates	intermediate	NNS
cord-284409-xiyeceib	137	40	of	of	IN
cord-284409-xiyeceib	137	41	VRC01-like	vrc01-like	NN
cord-284409-xiyeceib	137	42	antibodies	antibody	NNS
cord-284409-xiyeceib	137	43	.	.	.
cord-284409-xiyeceib	138	1	We	-PRON-	PRP
cord-284409-xiyeceib	138	2	previously	previously	RB
cord-284409-xiyeceib	138	3	observed	observe	VBD
cord-284409-xiyeceib	138	4	that	that	IN
cord-284409-xiyeceib	138	5	the	the	DT
cord-284409-xiyeceib	138	6	V	v	NN
cord-284409-xiyeceib	138	7	-	-	HYPH
cord-284409-xiyeceib	138	8	D	D	NNP
cord-284409-xiyeceib	138	9	-	-	HYPH
cord-284409-xiyeceib	138	10	J	J	NNP
cord-284409-xiyeceib	138	11	rearrangement	rearrangement	NN
cord-284409-xiyeceib	138	12	patterns	pattern	NNS
cord-284409-xiyeceib	138	13	occurred	occur	VBD
cord-284409-xiyeceib	138	14	at	at	IN
cord-284409-xiyeceib	138	15	different	different	JJ
cord-284409-xiyeceib	138	16	frequencies	frequency	NNS
cord-284409-xiyeceib	138	17	with	with	IN
cord-284409-xiyeceib	138	18	1,430	1,430	CD
cord-284409-xiyeceib	138	19	V	v	NN
cord-284409-xiyeceib	138	20	-	-	HYPH
cord-284409-xiyeceib	138	21	D	D	NNP
cord-284409-xiyeceib	138	22	-	-	HYPH
cord-284409-xiyeceib	138	23	J	J	NNP
cord-284409-xiyeceib	138	24	combinations	combination	NNS
cord-284409-xiyeceib	138	25	in	in	IN
cord-284409-xiyeceib	138	26	a	a	DT
cord-284409-xiyeceib	138	27	human	human	JJ
cord-284409-xiyeceib	138	28	cord	cord	NN
cord-284409-xiyeceib	138	29	blood	blood	NN
cord-284409-xiyeceib	138	30	IgM	IgM	NNP
cord-284409-xiyeceib	138	31	repertoire	repertoire	NN
cord-284409-xiyeceib	138	32	(	(	-LRB-
cord-284409-xiyeceib	138	33	19	19	CD
cord-284409-xiyeceib	138	34	)	)	-RRB-
cord-284409-xiyeceib	138	35	.	.	.
cord-284409-xiyeceib	139	1	Figure	figure	NN
cord-284409-xiyeceib	139	2	4A	4a	CD
cord-284409-xiyeceib	139	3	shows	show	VBZ
cord-284409-xiyeceib	139	4	the	the	DT
cord-284409-xiyeceib	139	5	V	v	NN
cord-284409-xiyeceib	139	6	-	-	HYPH
cord-284409-xiyeceib	139	7	D	D	NNP
cord-284409-xiyeceib	139	8	-	-	HYPH
cord-284409-xiyeceib	139	9	J	J	NNP
cord-284409-xiyeceib	139	10	diversity	diversity	NN
cord-284409-xiyeceib	139	11	associated	associate	VBN
cord-284409-xiyeceib	139	12	with	with	IN
cord-284409-xiyeceib	139	13	IGHV1	IGHV1	NNP
cord-284409-xiyeceib	139	14	-	-	HYPH
cord-284409-xiyeceib	139	15	2	2	CD
cord-284409-xiyeceib	139	16	gene	gene	NN
cord-284409-xiyeceib	139	17	sequences	sequence	NNS
cord-284409-xiyeceib	139	18	using	use	VBG
cord-284409-xiyeceib	139	19	a	a	DT
cord-284409-xiyeceib	139	20	bubble	bubble	NN
cord-284409-xiyeceib	139	21	plot	plot	NN
cord-284409-xiyeceib	139	22	for	for	IN
cord-284409-xiyeceib	139	23	comparison	comparison	NN
cord-284409-xiyeceib	139	24	with	with	IN
cord-284409-xiyeceib	139	25	different	different	JJ
cord-284409-xiyeceib	139	26	D	D	NNP
cord-284409-xiyeceib	139	27	and	and	CC
cord-284409-xiyeceib	139	28	J	J	NNP
cord-284409-xiyeceib	139	29	genes	gene	NNS
cord-284409-xiyeceib	139	30	.	.	.
cord-284409-xiyeceib	140	1	The	the	DT
cord-284409-xiyeceib	140	2	VRC01	VRC01	NNP
cord-284409-xiyeceib	140	3	heavy	heavy	JJ
cord-284409-xiyeceib	140	4	chain	chain	NN
cord-284409-xiyeceib	140	5	uses	use	VBZ
cord-284409-xiyeceib	140	6	IGHD3	IGHD3	NNP
cord-284409-xiyeceib	140	7	-	-	HYPH
cord-284409-xiyeceib	140	8	16	16	CD
cord-284409-xiyeceib	140	9	and	and	CC
cord-284409-xiyeceib	140	10	IGHJ2	IGHJ2	NNP
cord-284409-xiyeceib	140	11	genes	gene	NNS
cord-284409-xiyeceib	140	12	to	to	TO
cord-284409-xiyeceib	140	13	recombine	recombine	VB
cord-284409-xiyeceib	140	14	with	with	IN
cord-284409-xiyeceib	140	15	IGHV1	ighv1	NN
cord-284409-xiyeceib	140	16	-	-	SYM
cord-284409-xiyeceib	140	17	2	2	CD
cord-284409-xiyeceib	140	18	.	.	.
cord-284409-xiyeceib	141	1	However	however	RB
cord-284409-xiyeceib	141	2	,	,	,
cord-284409-xiyeceib	141	3	other	other	JJ
cord-284409-xiyeceib	141	4	VRC01-related	VRC01-related	NNP
cord-284409-xiyeceib	141	5	antibodies	antibody	NNS
cord-284409-xiyeceib	141	6	exhibit	exhibit	VBP
cord-284409-xiyeceib	141	7	a	a	DT
cord-284409-xiyeceib	141	8	skewed	skewed	JJ
cord-284409-xiyeceib	141	9	usage	usage	NN
cord-284409-xiyeceib	141	10	of	of	IN
cord-284409-xiyeceib	141	11	IGHJ	IGHJ	NNP
cord-284409-xiyeceib	141	12	genes	gene	NNS
cord-284409-xiyeceib	141	13	although	although	IN
cord-284409-xiyeceib	141	14	at	at	RB
cord-284409-xiyeceib	141	15	least	least	RBS
cord-284409-xiyeceib	141	16	three	three	CD
cord-284409-xiyeceib	141	17	different	different	JJ
cord-284409-xiyeceib	141	18	IGHJ	IGHJ	NNP
cord-284409-xiyeceib	141	19	genes	gene	NNS
cord-284409-xiyeceib	141	20	(	(	-LRB-
cord-284409-xiyeceib	141	21	IGHJ1	ighj1	UH
cord-284409-xiyeceib	141	22	,	,	,
cord-284409-xiyeceib	141	23	IGHJ2	ighj2	XX
cord-284409-xiyeceib	141	24	,	,	,
cord-284409-xiyeceib	141	25	and	and	CC
cord-284409-xiyeceib	141	26	IGHJ4	ighj4	NN
cord-284409-xiyeceib	141	27	)	)	-RRB-
cord-284409-xiyeceib	141	28	are	be	VBP
cord-284409-xiyeceib	141	29	involved	involve	VBN
cord-284409-xiyeceib	141	30	(	(	-LRB-
cord-284409-xiyeceib	141	31	23	23	CD
cord-284409-xiyeceib	141	32	)	)	-RRB-
cord-284409-xiyeceib	141	33	.	.	.
cord-284409-xiyeceib	142	1	As	as	IN
cord-284409-xiyeceib	142	2	the	the	DT
cord-284409-xiyeceib	142	3	human	human	JJ
cord-284409-xiyeceib	142	4	cord	cord	NN
cord-284409-xiyeceib	142	5	blood	blood	NNP
cord-284409-xiyeceib	142	6	IgM	IgM	NNP
cord-284409-xiyeceib	142	7	library	library	NNP
cord-284409-xiyeceib	142	8	has	have	VBZ
cord-284409-xiyeceib	142	9	a	a	DT
cord-284409-xiyeceib	142	10	large	large	JJ
cord-284409-xiyeceib	142	11	functional	functional	JJ
cord-284409-xiyeceib	142	12	V	v	NN
cord-284409-xiyeceib	142	13	-	-	HYPH
cord-284409-xiyeceib	142	14	D	D	NNP
cord-284409-xiyeceib	142	15	-	-	HYPH
cord-284409-xiyeceib	142	16	J	J	NNP
cord-284409-xiyeceib	142	17	diversity	diversity	NN
cord-284409-xiyeceib	142	18	,	,	,
cord-284409-xiyeceib	142	19	it	-PRON-	PRP
cord-284409-xiyeceib	142	20	can	can	MD
cord-284409-xiyeceib	142	21	be	be	VB
cord-284409-xiyeceib	142	22	used	use	VBN
cord-284409-xiyeceib	142	23	to	to	TO
cord-284409-xiyeceib	142	24	identify	identify	VB
cord-284409-xiyeceib	142	25	potential	potential	JJ
cord-284409-xiyeceib	142	26	VRC01-like	VRC01-like	``
cord-284409-xiyeceib	142	27	heavy	heavy	JJ
cord-284409-xiyeceib	142	28	chain	chain	NN
cord-284409-xiyeceib	142	29	germline	germline	NN
cord-284409-xiyeceib	142	30	precursors	precursor	NNS
cord-284409-xiyeceib	142	31	and	and	CC
cord-284409-xiyeceib	142	32	intermediates	intermediate	NNS
cord-284409-xiyeceib	142	33	.	.	.
cord-284409-xiyeceib	143	1	In	in	IN
cord-284409-xiyeceib	143	2	jawed	jawed	JJ
cord-284409-xiyeceib	143	3	vertebrates	vertebrate	NNS
cord-284409-xiyeceib	143	4	the	the	DT
cord-284409-xiyeceib	143	5	expressed	express	VBN
cord-284409-xiyeceib	143	6	heavy	heavy	JJ
cord-284409-xiyeceib	143	7	chains	chain	NNS
cord-284409-xiyeceib	143	8	may	may	MD
cord-284409-xiyeceib	143	9	use	use	VB
cord-284409-xiyeceib	143	10	any	any	DT
cord-284409-xiyeceib	143	11	of	of	IN
cord-284409-xiyeceib	143	12	the	the	DT
cord-284409-xiyeceib	143	13	six	six	CD
cord-284409-xiyeceib	143	14	IGHD	IGHD	NNP
cord-284409-xiyeceib	143	15	reading	read	VBG
cord-284409-xiyeceib	143	16	frames	frame	NNS
cord-284409-xiyeceib	143	17	(	(	-LRB-
cord-284409-xiyeceib	143	18	RFs	RFs	NNP
cord-284409-xiyeceib	143	19	)	)	-RRB-
cord-284409-xiyeceib	143	20	;	;	:
cord-284409-xiyeceib	143	21	however	however	RB
cord-284409-xiyeceib	143	22	,	,	,
cord-284409-xiyeceib	143	23	RF1	RF1	NNP
cord-284409-xiyeceib	143	24	is	be	VBZ
cord-284409-xiyeceib	143	25	thought	think	VBN
cord-284409-xiyeceib	143	26	to	to	TO
cord-284409-xiyeceib	143	27	be	be	VB
cord-284409-xiyeceib	143	28	the	the	DT
cord-284409-xiyeceib	143	29	preferred	preferred	JJ
cord-284409-xiyeceib	143	30	one	one	NN
cord-284409-xiyeceib	143	31	as	as	IN
cord-284409-xiyeceib	143	32	it	-PRON-	PRP
cord-284409-xiyeceib	143	33	mostly	mostly	RB
cord-284409-xiyeceib	143	34	encodes	encode	VBZ
cord-284409-xiyeceib	143	35	tyrosine	tyrosine	NN
cord-284409-xiyeceib	143	36	and	and	CC
cord-284409-xiyeceib	143	37	glycine	glycine	NN
cord-284409-xiyeceib	143	38	.	.	.
cord-284409-xiyeceib	144	1	The	the	DT
cord-284409-xiyeceib	144	2	remaining	remain	VBG
cord-284409-xiyeceib	144	3	five	five	CD
cord-284409-xiyeceib	144	4	RFs	rf	NNS
cord-284409-xiyeceib	144	5	encode	encode	VB
cord-284409-xiyeceib	144	6	either	either	CC
cord-284409-xiyeceib	144	7	hydrophobic	hydrophobic	JJ
cord-284409-xiyeceib	144	8	or	or	CC
cord-284409-xiyeceib	144	9	charged	charge	VBN
cord-284409-xiyeceib	144	10	amino	amino	NN
cord-284409-xiyeceib	144	11	acids	acid	NNS
cord-284409-xiyeceib	144	12	,	,	,
cord-284409-xiyeceib	144	13	but	but	CC
cord-284409-xiyeceib	144	14	the	the	DT
cord-284409-xiyeceib	144	15	use	use	NN
cord-284409-xiyeceib	144	16	of	of	IN
cord-284409-xiyeceib	144	17	inverted	inverted	JJ
cord-284409-xiyeceib	144	18	RF1	rf1	NN
cord-284409-xiyeceib	144	19	,	,	,
cord-284409-xiyeceib	144	20	RF2	RF2	NNP
cord-284409-xiyeceib	144	21	,	,	,
cord-284409-xiyeceib	144	22	and	and	CC
cord-284409-xiyeceib	144	23	RF3	rf3	NN
cord-284409-xiyeceib	144	24	are	be	VBP
cord-284409-xiyeceib	144	25	discouraged	discouraged	JJ
cord-284409-xiyeceib	144	26	.	.	.
cord-284409-xiyeceib	145	1	Preferential	preferential	JJ
cord-284409-xiyeceib	145	2	usage	usage	NN
cord-284409-xiyeceib	145	3	of	of	IN
cord-284409-xiyeceib	145	4	IGHD	IGHD	NNP
cord-284409-xiyeceib	145	5	RFs	RFs	NNP
cord-284409-xiyeceib	145	6	has	have	VBZ
cord-284409-xiyeceib	145	7	been	be	VBN
cord-284409-xiyeceib	145	8	long	long	RB
cord-284409-xiyeceib	145	9	implicated	implicate	VBN
cord-284409-xiyeceib	145	10	in	in	IN
cord-284409-xiyeceib	145	11	B	b	NN
cord-284409-xiyeceib	145	12	cell	cell	NN
cord-284409-xiyeceib	145	13	development	development	NN
cord-284409-xiyeceib	145	14	and	and	CC
cord-284409-xiyeceib	145	15	antigen	antigen	NN
cord-284409-xiyeceib	145	16	-	-	HYPH
cord-284409-xiyeceib	145	17	specific	specific	JJ
cord-284409-xiyeceib	145	18	antibody	antibody	NN
cord-284409-xiyeceib	145	19	production	production	NN
cord-284409-xiyeceib	145	20	(	(	-LRB-
cord-284409-xiyeceib	145	21	43	43	CD
cord-284409-xiyeceib	145	22	)	)	-RRB-
cord-284409-xiyeceib	145	23	(	(	-LRB-
cord-284409-xiyeceib	145	24	44	44	CD
cord-284409-xiyeceib	145	25	)	)	-RRB-
cord-284409-xiyeceib	145	26	(	(	-LRB-
cord-284409-xiyeceib	145	27	45	45	CD
cord-284409-xiyeceib	145	28	)	)	-RRB-
cord-284409-xiyeceib	145	29	,	,	,
cord-284409-xiyeceib	145	30	and	and	CC
cord-284409-xiyeceib	145	31	selected	select	VBN
cord-284409-xiyeceib	145	32	based	base	VBN
cord-284409-xiyeceib	145	33	upon	upon	IN
cord-284409-xiyeceib	145	34	its	-PRON-	PRP$
cord-284409-xiyeceib	145	35	amino	amino	NN
cord-284409-xiyeceib	145	36	acid	acid	NN
cord-284409-xiyeceib	145	37	content	content	NN
cord-284409-xiyeceib	145	38	(	(	-LRB-
cord-284409-xiyeceib	145	39	46	46	CD
cord-284409-xiyeceib	145	40	)	)	-RRB-
cord-284409-xiyeceib	145	41	.	.	.
cord-284409-xiyeceib	146	1	Genetic	genetic	JJ
cord-284409-xiyeceib	146	2	control	control	NN
cord-284409-xiyeceib	146	3	of	of	IN
cord-284409-xiyeceib	146	4	IGDH	IGDH	NNP
cord-284409-xiyeceib	146	5	RF	RF	NNP
cord-284409-xiyeceib	146	6	preference	preference	NN
cord-284409-xiyeceib	146	7	over	over	IN
cord-284409-xiyeceib	146	8	the	the	DT
cord-284409-xiyeceib	146	9	regulation	regulation	NN
cord-284409-xiyeceib	146	10	of	of	IN
cord-284409-xiyeceib	146	11	repertoire	repertoire	NN
cord-284409-xiyeceib	146	12	development	development	NN
cord-284409-xiyeceib	146	13	has	have	VBZ
cord-284409-xiyeceib	146	14	been	be	VBN
cord-284409-xiyeceib	146	15	recognized	recognize	VBN
cord-284409-xiyeceib	146	16	(	(	-LRB-
cord-284409-xiyeceib	146	17	47	47	CD
cord-284409-xiyeceib	146	18	)	)	-RRB-
cord-284409-xiyeceib	146	19	.	.	.
cord-284409-xiyeceib	147	1	Here	here	RB
cord-284409-xiyeceib	147	2	,	,	,
cord-284409-xiyeceib	147	3	we	-PRON-	PRP
cord-284409-xiyeceib	147	4	have	have	VBP
cord-284409-xiyeceib	147	5	analyzed	analyze	VBN
cord-284409-xiyeceib	147	6	the	the	DT
cord-284409-xiyeceib	147	7	productive	productive	JJ
cord-284409-xiyeceib	147	8	IGHD	IGHD	NNP
cord-284409-xiyeceib	147	9	RF	rf	NN
cord-284409-xiyeceib	147	10	usages	usage	NNS
cord-284409-xiyeceib	147	11	in	in	IN
cord-284409-xiyeceib	147	12	a	a	DT
cord-284409-xiyeceib	147	13	human	human	JJ
cord-284409-xiyeceib	147	14	cord	cord	NN
cord-284409-xiyeceib	147	15	blood	blood	NN
cord-284409-xiyeceib	147	16	IgM	IgM	NNP
cord-284409-xiyeceib	147	17	library	library	NNP
cord-284409-xiyeceib	147	18	.	.	.
cord-284409-xiyeceib	148	1	Frequency	frequency	NN
cord-284409-xiyeceib	148	2	distribution	distribution	NN
cord-284409-xiyeceib	148	3	of	of	IN
cord-284409-xiyeceib	148	4	RFs	rf	NNS
cord-284409-xiyeceib	148	5	is	be	VBZ
cord-284409-xiyeceib	148	6	plotted	plot	VBN
cord-284409-xiyeceib	148	7	using	use	VBG
cord-284409-xiyeceib	148	8	a	a	DT
cord-284409-xiyeceib	148	9	pie	pie	NN
cord-284409-xiyeceib	148	10	chart	chart	NN
cord-284409-xiyeceib	148	11	as	as	IN
cord-284409-xiyeceib	148	12	depicted	depict	VBN
cord-284409-xiyeceib	148	13	in	in	IN
cord-284409-xiyeceib	148	14	Figure	figure	NN
cord-284409-xiyeceib	148	15	4B	4b	NN
cord-284409-xiyeceib	148	16	.	.	.
cord-284409-xiyeceib	149	1	We	-PRON-	PRP
cord-284409-xiyeceib	149	2	noted	note	VBD
cord-284409-xiyeceib	149	3	that	that	IN
cord-284409-xiyeceib	149	4	there	there	EX
cord-284409-xiyeceib	149	5	were	be	VBD
cord-284409-xiyeceib	149	6	not	not	RB
cord-284409-xiyeceib	149	7	any	any	DT
cord-284409-xiyeceib	149	8	highly	highly	RB
cord-284409-xiyeceib	149	9	restricted	restrict	VBN
cord-284409-xiyeceib	149	10	usages	usage	NNS
cord-284409-xiyeceib	149	11	of	of	IN
cord-284409-xiyeceib	149	12	the	the	DT
cord-284409-xiyeceib	149	13	IGHD	IGHD	NNP
cord-284409-xiyeceib	149	14	RFs	RFs	NNPS
cord-284409-xiyeceib	149	15	although	although	IN
cord-284409-xiyeceib	149	16	some	some	DT
cord-284409-xiyeceib	149	17	preferential	preferential	JJ
cord-284409-xiyeceib	149	18	usages	usage	NNS
cord-284409-xiyeceib	149	19	depending	depend	VBG
cord-284409-xiyeceib	149	20	on	on	IN
cord-284409-xiyeceib	149	21	the	the	DT
cord-284409-xiyeceib	149	22	IGHD	IGHD	NNP
cord-284409-xiyeceib	149	23	genes	gene	NNS
cord-284409-xiyeceib	149	24	were	be	VBD
cord-284409-xiyeceib	149	25	found	find	VBN
cord-284409-xiyeceib	149	26	.	.	.
cord-284409-xiyeceib	150	1	This	this	DT
cord-284409-xiyeceib	150	2	clearly	clearly	RB
cord-284409-xiyeceib	150	3	indicates	indicate	VBZ
cord-284409-xiyeceib	150	4	that	that	IN
cord-284409-xiyeceib	150	5	IGHD	IGHD	NNP
cord-284409-xiyeceib	150	6	RFs	RFs	NNP
cord-284409-xiyeceib	150	7	diversity	diversity	NN
cord-284409-xiyeceib	150	8	could	could	MD
cord-284409-xiyeceib	150	9	add	add	VB
cord-284409-xiyeceib	150	10	more	more	RBR
cord-284409-xiyeceib	150	11	diverse	diverse	JJ
cord-284409-xiyeceib	150	12	amino	amino	NN
cord-284409-xiyeceib	150	13	acid	acid	NN
cord-284409-xiyeceib	150	14	contents	content	NNS
cord-284409-xiyeceib	150	15	leading	lead	VBG
cord-284409-xiyeceib	150	16	to	to	IN
cord-284409-xiyeceib	150	17	enormous	enormous	JJ
cord-284409-xiyeceib	150	18	CDRH3	cdrh3	NN
cord-284409-xiyeceib	150	19	diversity	diversity	NN
cord-284409-xiyeceib	150	20	.	.	.
cord-284409-xiyeceib	151	1	It	-PRON-	PRP
cord-284409-xiyeceib	151	2	may	may	MD
cord-284409-xiyeceib	151	3	also	also	RB
cord-284409-xiyeceib	151	4	be	be	VB
cord-284409-xiyeceib	151	5	possible	possible	JJ
cord-284409-xiyeceib	151	6	that	that	IN
cord-284409-xiyeceib	151	7	intermediates	intermediate	NNS
cord-284409-xiyeceib	151	8	with	with	IN
cord-284409-xiyeceib	151	9	different	different	JJ
cord-284409-xiyeceib	151	10	RF	rf	NN
cord-284409-xiyeceib	151	11	choices	choice	NNS
cord-284409-xiyeceib	151	12	play	play	VBP
cord-284409-xiyeceib	151	13	a	a	DT
cord-284409-xiyeceib	151	14	critical	critical	JJ
cord-284409-xiyeceib	151	15	role	role	NN
cord-284409-xiyeceib	151	16	in	in	IN
cord-284409-xiyeceib	151	17	selecting	select	VBG
cord-284409-xiyeceib	151	18	certain	certain	JJ
cord-284409-xiyeceib	151	19	maturation	maturation	NN
cord-284409-xiyeceib	151	20	pathways	pathway	NNS
cord-284409-xiyeceib	151	21	efficiently	efficiently	RB
cord-284409-xiyeceib	151	22	.	.	.
cord-284409-xiyeceib	152	1	The	the	DT
cord-284409-xiyeceib	152	2	antibody	antibody	NN
cord-284409-xiyeceib	152	3	germline	germline	NN
cord-284409-xiyeceib	152	4	/	/	SYM
cord-284409-xiyeceib	152	5	maturation	maturation	NN
cord-284409-xiyeceib	152	6	hypothesis	hypothesis	NN
cord-284409-xiyeceib	152	7	led	lead	VBD
cord-284409-xiyeceib	152	8	to	to	IN
cord-284409-xiyeceib	152	9	a	a	DT
cord-284409-xiyeceib	152	10	paradigm	paradigm	NN
cord-284409-xiyeceib	152	11	shift	shift	NN
cord-284409-xiyeceib	152	12	in	in	IN
cord-284409-xiyeceib	152	13	the	the	DT
cord-284409-xiyeceib	152	14	design	design	NN
cord-284409-xiyeceib	152	15	of	of	IN
cord-284409-xiyeceib	152	16	immunogens	immunogen	NNS
cord-284409-xiyeceib	152	17	for	for	IN
cord-284409-xiyeceib	152	18	bnAb	bnab	CD
cord-284409-xiyeceib	152	19	elicitation	elicitation	NN
cord-284409-xiyeceib	152	20	,	,	,
cord-284409-xiyeceib	152	21	as	as	RB
cord-284409-xiyeceib	152	22	well	well	RB
cord-284409-xiyeceib	152	23	as	as	IN
cord-284409-xiyeceib	152	24	the	the	DT
cord-284409-xiyeceib	152	25	realization	realization	NN
cord-284409-xiyeceib	152	26	of	of	IN
cord-284409-xiyeceib	152	27	the	the	DT
cord-284409-xiyeceib	152	28	importance	importance	NN
cord-284409-xiyeceib	152	29	of	of	IN
cord-284409-xiyeceib	152	30	the	the	DT
cord-284409-xiyeceib	152	31	complexity	complexity	NN
cord-284409-xiyeceib	152	32	of	of	IN
cord-284409-xiyeceib	152	33	the	the	DT
cord-284409-xiyeceib	152	34	bnAb	bnab	CD
cord-284409-xiyeceib	152	35	maturation	maturation	NN
cord-284409-xiyeceib	152	36	pathways	pathway	NNS
cord-284409-xiyeceib	152	37	,	,	,
cord-284409-xiyeceib	152	38	and	and	CC
cord-284409-xiyeceib	152	39	exploration	exploration	NN
cord-284409-xiyeceib	152	40	of	of	IN
cord-284409-xiyeceib	152	41	human	human	JJ
cord-284409-xiyeceib	152	42	antibodyomes	antibodyome	NNS
cord-284409-xiyeceib	152	43	(	(	-LRB-
cord-284409-xiyeceib	152	44	14	14	CD
cord-284409-xiyeceib	152	45	)	)	-RRB-
cord-284409-xiyeceib	152	46	.	.	.
cord-284409-xiyeceib	153	1	In	in	IN
cord-284409-xiyeceib	153	2	fact	fact	NN
cord-284409-xiyeceib	153	3	,	,	,
cord-284409-xiyeceib	153	4	human	human	JJ
cord-284409-xiyeceib	153	5	antibodyome	antibodyome	NN
cord-284409-xiyeceib	153	6	exploration	exploration	NN
cord-284409-xiyeceib	153	7	is	be	VBZ
cord-284409-xiyeceib	153	8	also	also	RB
cord-284409-xiyeceib	153	9	promising	promise	VBG
cord-284409-xiyeceib	153	10	for	for	IN
cord-284409-xiyeceib	153	11	other	other	JJ
cord-284409-xiyeceib	153	12	fields	field	NNS
cord-284409-xiyeceib	153	13	of	of	IN
cord-284409-xiyeceib	153	14	science	science	NN
cord-284409-xiyeceib	153	15	and	and	CC
cord-284409-xiyeceib	153	16	medicine	medicine	NN
cord-284409-xiyeceib	153	17	(	(	-LRB-
cord-284409-xiyeceib	153	18	14	14	CD
cord-284409-xiyeceib	153	19	,	,	,
cord-284409-xiyeceib	153	20	48	48	CD
cord-284409-xiyeceib	153	21	)	)	-RRB-
cord-284409-xiyeceib	153	22	.	.	.
cord-284409-xiyeceib	154	1	This	this	DT
cord-284409-xiyeceib	154	2	antibodyome	antibodyome	NN
cord-284409-xiyeceib	154	3	approach	approach	NN
cord-284409-xiyeceib	154	4	is	be	VBZ
cord-284409-xiyeceib	154	5	now	now	RB
cord-284409-xiyeceib	154	6	a	a	DT
cord-284409-xiyeceib	154	7	major	major	JJ
cord-284409-xiyeceib	154	8	direction	direction	NN
cord-284409-xiyeceib	154	9	of	of	IN
cord-284409-xiyeceib	154	10	research	research	NN
cord-284409-xiyeceib	154	11	in	in	IN
cord-284409-xiyeceib	154	12	the	the	DT
cord-284409-xiyeceib	154	13	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	154	14	vaccine	vaccine	NN
cord-284409-xiyeceib	154	15	field	field	NN
cord-284409-xiyeceib	154	16	(	(	-LRB-
cord-284409-xiyeceib	154	17	16	16	CD
cord-284409-xiyeceib	154	18	,	,	,
cord-284409-xiyeceib	154	19	49	49	CD
cord-284409-xiyeceib	154	20	)	)	-RRB-
cord-284409-xiyeceib	154	21	.	.	.
cord-284409-xiyeceib	155	1	An	an	DT
cord-284409-xiyeceib	155	2	important	important	JJ
cord-284409-xiyeceib	155	3	goal	goal	NN
cord-284409-xiyeceib	155	4	is	be	VBZ
cord-284409-xiyeceib	155	5	to	to	TO
cord-284409-xiyeceib	155	6	precisely	precisely	RB
cord-284409-xiyeceib	155	7	identify	identify	VB
cord-284409-xiyeceib	155	8	naturally	naturally	RB
cord-284409-xiyeceib	155	9	occurring	occur	VBG
cord-284409-xiyeceib	155	10	germline	germline	NN
cord-284409-xiyeceib	155	11	-	-	HYPH
cord-284409-xiyeceib	155	12	like	like	JJ
cord-284409-xiyeceib	155	13	precursors	precursor	NNS
cord-284409-xiyeceib	155	14	and	and	CC
cord-284409-xiyeceib	155	15	intermediates	intermediate	NNS
cord-284409-xiyeceib	155	16	of	of	IN
cord-284409-xiyeceib	155	17	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	155	18	that	that	WDT
cord-284409-xiyeceib	155	19	could	could	MD
cord-284409-xiyeceib	155	20	help	help	VB
cord-284409-xiyeceib	155	21	designing	design	VBG
cord-284409-xiyeceib	155	22	novel	novel	JJ
cord-284409-xiyeceib	155	23	immunogens	immunogen	NNS
cord-284409-xiyeceib	155	24	,	,	,
cord-284409-xiyeceib	155	25	which	which	WDT
cord-284409-xiyeceib	155	26	could	could	MD
cord-284409-xiyeceib	155	27	activate	activate	VB
cord-284409-xiyeceib	155	28	the	the	DT
cord-284409-xiyeceib	155	29	corresponding	correspond	VBG
cord-284409-xiyeceib	155	30	BCRs	bcr	NNS
cord-284409-xiyeceib	155	31	and	and	CC
cord-284409-xiyeceib	155	32	drive	drive	VB
cord-284409-xiyeceib	155	33	the	the	DT
cord-284409-xiyeceib	155	34	immune	immune	JJ
cord-284409-xiyeceib	155	35	system	system	NN
cord-284409-xiyeceib	155	36	to	to	TO
cord-284409-xiyeceib	155	37	produce	produce	VB
cord-284409-xiyeceib	155	38	bnAbs	bnabs	NN
cord-284409-xiyeceib	155	39	within	within	IN
cord-284409-xiyeceib	155	40	a	a	DT
cord-284409-xiyeceib	155	41	short	short	JJ
cord-284409-xiyeceib	155	42	period	period	NN
cord-284409-xiyeceib	155	43	of	of	IN
cord-284409-xiyeceib	155	44	time	time	NN
cord-284409-xiyeceib	155	45	.	.	.
cord-284409-xiyeceib	156	1	We	-PRON-	PRP
cord-284409-xiyeceib	156	2	presented	present	VBD
cord-284409-xiyeceib	156	3	an	an	DT
cord-284409-xiyeceib	156	4	approach	approach	NN
cord-284409-xiyeceib	156	5	using	use	VBG
cord-284409-xiyeceib	156	6	a	a	DT
cord-284409-xiyeceib	156	7	human	human	JJ
cord-284409-xiyeceib	156	8	cord	cord	NN
cord-284409-xiyeceib	156	9	blood	blood	NN
cord-284409-xiyeceib	156	10	IgM	IgM	NNP
cord-284409-xiyeceib	156	11	library	library	NNP
cord-284409-xiyeceib	156	12	to	to	TO
cord-284409-xiyeceib	156	13	identify	identify	VB
cord-284409-xiyeceib	156	14	putative	putative	JJ
cord-284409-xiyeceib	156	15	germline	germline	JJ
cord-284409-xiyeceib	156	16	precursors	precursor	NNS
cord-284409-xiyeceib	156	17	and	and	CC
cord-284409-xiyeceib	156	18	intermediates	intermediate	NNS
cord-284409-xiyeceib	156	19	of	of	IN
cord-284409-xiyeceib	156	20	VRC01-like	vrc01-like	UH
cord-284409-xiyeceib	156	21	heavy	heavy	JJ
cord-284409-xiyeceib	156	22	and	and	CC
cord-284409-xiyeceib	156	23	light	light	JJ
cord-284409-xiyeceib	156	24	chains	chain	NNS
cord-284409-xiyeceib	156	25	,	,	,
cord-284409-xiyeceib	156	26	which	which	WDT
cord-284409-xiyeceib	156	27	could	could	MD
cord-284409-xiyeceib	156	28	be	be	VB
cord-284409-xiyeceib	156	29	useful	useful	JJ
cord-284409-xiyeceib	156	30	in	in	IN
cord-284409-xiyeceib	156	31	reconstructing	reconstruct	VBG
cord-284409-xiyeceib	156	32	the	the	DT
cord-284409-xiyeceib	156	33	B	b	NN
cord-284409-xiyeceib	156	34	cell	cell	NN
cord-284409-xiyeceib	156	35	clonal	clonal	JJ
cord-284409-xiyeceib	156	36	lineages	lineage	NNS
cord-284409-xiyeceib	156	37	in	in	IN
cord-284409-xiyeceib	156	38	the	the	DT
cord-284409-xiyeceib	156	39	maturation	maturation	NN
cord-284409-xiyeceib	156	40	pathways	pathway	NNS
cord-284409-xiyeceib	156	41	of	of	IN
cord-284409-xiyeceib	156	42	VRC01-related	VRC01-related	NNP
cord-284409-xiyeceib	156	43	bnAbs	bnAbs	NNP
cord-284409-xiyeceib	156	44	.	.	.
cord-284409-xiyeceib	157	1	This	this	DT
cord-284409-xiyeceib	157	2	method	method	NN
cord-284409-xiyeceib	157	3	has	have	VBZ
cord-284409-xiyeceib	157	4	the	the	DT
cord-284409-xiyeceib	157	5	potential	potential	NN
cord-284409-xiyeceib	157	6	to	to	TO
cord-284409-xiyeceib	157	7	help	help	VB
cord-284409-xiyeceib	157	8	in	in	IN
cord-284409-xiyeceib	157	9	the	the	DT
cord-284409-xiyeceib	157	10	identification	identification	NN
cord-284409-xiyeceib	157	11	of	of	IN
cord-284409-xiyeceib	157	12	naturally	naturally	RB
cord-284409-xiyeceib	157	13	occurring	occur	VBG
cord-284409-xiyeceib	157	14	germline	germline	NN
cord-284409-xiyeceib	157	15	-	-	HYPH
cord-284409-xiyeceib	157	16	like	like	JJ
cord-284409-xiyeceib	157	17	precursors	precursor	NNS
cord-284409-xiyeceib	157	18	and	and	CC
cord-284409-xiyeceib	157	19	intermediates	intermediate	NNS
cord-284409-xiyeceib	157	20	of	of	IN
cord-284409-xiyeceib	157	21	any	any	DT
cord-284409-xiyeceib	157	22	known	know	VBN
cord-284409-xiyeceib	157	23	bnAb	bnAb	''
cord-284409-xiyeceib	157	24	and	and	CC
cord-284409-xiyeceib	157	25	in	in	IN
cord-284409-xiyeceib	157	26	the	the	DT
cord-284409-xiyeceib	157	27	development	development	NN
cord-284409-xiyeceib	157	28	immunogens	immunogen	NNS
cord-284409-xiyeceib	157	29	based	base	VBN
cord-284409-xiyeceib	157	30	on	on	IN
cord-284409-xiyeceib	157	31	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	157	32	Envs	Envs	NNP
cord-284409-xiyeceib	157	33	(	(	-LRB-
cord-284409-xiyeceib	157	34	50	50	CD
cord-284409-xiyeceib	157	35	)	)	-RRB-
cord-284409-xiyeceib	157	36	and	and	CC
cord-284409-xiyeceib	157	37	peptides	peptide	NNS
cord-284409-xiyeceib	157	38	(	(	-LRB-
cord-284409-xiyeceib	157	39	51	51	CD
cord-284409-xiyeceib	157	40	)	)	-RRB-
cord-284409-xiyeceib	157	41	,	,	,
cord-284409-xiyeceib	157	42	as	as	RB
cord-284409-xiyeceib	157	43	well	well	RB
cord-284409-xiyeceib	157	44	as	as	IN
cord-284409-xiyeceib	157	45	non	non	JJ
cord-284409-xiyeceib	157	46	-	-	JJ
cord-284409-xiyeceib	157	47	HIV-1	hiv-1	JJ
cord-284409-xiyeceib	157	48	molecules	molecule	NNS
cord-284409-xiyeceib	157	49	(	(	-LRB-
cord-284409-xiyeceib	157	50	12	12	CD
cord-284409-xiyeceib	157	51	)	)	-RRB-
cord-284409-xiyeceib	157	52	.	.	.
cord-284409-xiyeceib	158	1	However	however	RB
cord-284409-xiyeceib	158	2	,	,	,
cord-284409-xiyeceib	158	3	major	major	JJ
cord-284409-xiyeceib	158	4	challenges	challenge	NNS
cord-284409-xiyeceib	158	5	remain	remain	VBP
cord-284409-xiyeceib	158	6	and	and	CC
cord-284409-xiyeceib	158	7	new	new	JJ
cord-284409-xiyeceib	158	8	paradigms	paradigm	NNS
cord-284409-xiyeceib	158	9	that	that	WDT
cord-284409-xiyeceib	158	10	better	well	RBR
cord-284409-xiyeceib	158	11	fit	fit	VBP
cord-284409-xiyeceib	158	12	our	-PRON-	PRP$
cord-284409-xiyeceib	158	13	increased	increased	JJ
cord-284409-xiyeceib	158	14	knowledge	knowledge	NN
cord-284409-xiyeceib	158	15	of	of	IN
cord-284409-xiyeceib	158	16	HIV	HIV	NNP
cord-284409-xiyeceib	158	17	immunopathology	immunopathology	NN
cord-284409-xiyeceib	158	18	could	could	MD
cord-284409-xiyeceib	158	19	possibly	possibly	RB
cord-284409-xiyeceib	158	20	be	be	VB
cord-284409-xiyeceib	158	21	more	more	RBR
cord-284409-xiyeceib	158	22	helpful	helpful	JJ
cord-284409-xiyeceib	158	23	in	in	IN
cord-284409-xiyeceib	158	24	guiding	guide	VBG
cord-284409-xiyeceib	158	25	future	future	JJ
cord-284409-xiyeceib	158	26	vaccine	vaccine	NN
cord-284409-xiyeceib	158	27	research	research	NN
cord-284409-xiyeceib	158	28	than	than	IN
cord-284409-xiyeceib	158	29	did	do	VBD
cord-284409-xiyeceib	158	30	past	past	JJ
cord-284409-xiyeceib	158	31	unsuccessful	unsuccessful	JJ
cord-284409-xiyeceib	158	32	approaches	approach	NNS
cord-284409-xiyeceib	158	33	(	(	-LRB-
cord-284409-xiyeceib	158	34	17	17	CD
cord-284409-xiyeceib	158	35	)	)	-RRB-
cord-284409-xiyeceib	158	36	.	.	.
cord-284409-xiyeceib	159	1	We	-PRON-	PRP
cord-284409-xiyeceib	159	2	thank	thank	VBP
cord-284409-xiyeceib	159	3	the	the	DT
cord-284409-xiyeceib	159	4	Laboratory	Laboratory	NNP
cord-284409-xiyeceib	159	5	of	of	IN
cord-284409-xiyeceib	159	6	Molecular	Molecular	NNP
cord-284409-xiyeceib	159	7	Technology	Technology	NNP
cord-284409-xiyeceib	159	8	of	of	IN
cord-284409-xiyeceib	159	9	SAIC	SAIC	NNP
cord-284409-xiyeceib	159	10	-	-	HYPH
cord-284409-xiyeceib	159	11	Frederick	Frederick	NNP
cord-284409-xiyeceib	159	12	,	,	,
cord-284409-xiyeceib	159	13	Inc.	Inc.	NNP
cord-284409-xiyeceib	159	14	,	,	,
cord-284409-xiyeceib	159	15	for	for	IN
cord-284409-xiyeceib	159	16	providing	provide	VBG
cord-284409-xiyeceib	159	17	Roche	Roche	NNP
cord-284409-xiyeceib	159	18	454	454	CD
cord-284409-xiyeceib	159	19	sequencing	sequencing	NN
cord-284409-xiyeceib	159	20	service	service	NN
cord-284409-xiyeceib	159	21	.	.	.
cord-284409-xiyeceib	160	1	We	-PRON-	PRP
cord-284409-xiyeceib	160	2	thank	thank	VBP
cord-284409-xiyeceib	160	3	Tina	Tina	NNP
cord-284409-xiyeceib	160	4	Ju	Ju	NNP
cord-284409-xiyeceib	160	5	for	for	IN
cord-284409-xiyeceib	160	6	critically	critically	RB
cord-284409-xiyeceib	160	7	reading	read	VBG
cord-284409-xiyeceib	160	8	the	the	DT
cord-284409-xiyeceib	160	9	manuscript	manuscript	NN
cord-284409-xiyeceib	160	10	.	.	.
cord-284409-xiyeceib	161	1	This	this	DT
cord-284409-xiyeceib	161	2	research	research	NN
cord-284409-xiyeceib	161	3	was	be	VBD
cord-284409-xiyeceib	161	4	supported	support	VBN
cord-284409-xiyeceib	161	5	by	by	IN
cord-284409-xiyeceib	161	6	the	the	DT
cord-284409-xiyeceib	161	7	Intramural	Intramural	NNP
cord-284409-xiyeceib	161	8	Research	Research	NNP
cord-284409-xiyeceib	161	9	Program	Program	NNP
cord-284409-xiyeceib	161	10	of	of	IN
cord-284409-xiyeceib	161	11	the	the	DT
cord-284409-xiyeceib	161	12	NIH	NIH	NNP
cord-284409-xiyeceib	161	13	,	,	,
cord-284409-xiyeceib	161	14	National	National	NNP
cord-284409-xiyeceib	161	15	Cancer	Cancer	NNP
cord-284409-xiyeceib	161	16	Institute	Institute	NNP
cord-284409-xiyeceib	161	17	,	,	,
cord-284409-xiyeceib	161	18	Center	Center	NNP
cord-284409-xiyeceib	161	19	for	for	IN
cord-284409-xiyeceib	161	20	Cancer	Cancer	NNP
cord-284409-xiyeceib	161	21	Research	Research	NNP
cord-284409-xiyeceib	161	22	,	,	,
cord-284409-xiyeceib	161	23	the	the	DT
cord-284409-xiyeceib	161	24	Intramural	Intramural	NNP
cord-284409-xiyeceib	161	25	AIDS	AIDS	NNP
cord-284409-xiyeceib	161	26	Targeted	Targeted	NNP
cord-284409-xiyeceib	161	27	Antiviral	Antiviral	NNP
cord-284409-xiyeceib	161	28	Program	Program	NNP
cord-284409-xiyeceib	161	29	(	(	-LRB-
cord-284409-xiyeceib	161	30	IATAP	IATAP	NNP
cord-284409-xiyeceib	161	31	)	)	-RRB-
cord-284409-xiyeceib	161	32	of	of	IN
cord-284409-xiyeceib	161	33	the	the	DT
cord-284409-xiyeceib	161	34	NIH	NIH	NNP
cord-284409-xiyeceib	161	35	and	and	CC
cord-284409-xiyeceib	161	36	by	by	IN
cord-284409-xiyeceib	161	37	Federal	Federal	NNP
cord-284409-xiyeceib	161	38	funds	fund	NNS
cord-284409-xiyeceib	161	39	from	from	IN
cord-284409-xiyeceib	161	40	the	the	DT
cord-284409-xiyeceib	161	41	NIH	NIH	NNP
cord-284409-xiyeceib	161	42	,	,	,
cord-284409-xiyeceib	161	43	National	National	NNP
cord-284409-xiyeceib	161	44	Cancer	Cancer	NNP
cord-284409-xiyeceib	161	45	Institute	Institute	NNP
cord-284409-xiyeceib	161	46	,	,	,
cord-284409-xiyeceib	161	47	under	under	IN
cord-284409-xiyeceib	161	48	Contract	Contract	NNP
cord-284409-xiyeceib	161	49	Nos	Nos	NNP
cord-284409-xiyeceib	161	50	.	.	.
cord-284409-xiyeceib	162	1	NO1-CO-12400	NO1-CO-12400	NNP
cord-284409-xiyeceib	163	1	and	and	CC
cord-284409-xiyeceib	163	2	HHSN261200800001E.	HHSN261200800001E.	NNP
cord-284409-xiyeceib	164	1	The	the	DT
cord-284409-xiyeceib	164	2	www.frontiersin.org	www.frontiersin.org	NN
cord-284409-xiyeceib	165	1	The	the	DT
cord-284409-xiyeceib	165	2	antigenic	antigenic	JJ
cord-284409-xiyeceib	165	3	structure	structure	NN
cord-284409-xiyeceib	165	4	of	of	IN
cord-284409-xiyeceib	165	5	the	the	DT
cord-284409-xiyeceib	165	6	HIV	HIV	NNP
cord-284409-xiyeceib	165	7	gp120	gp120	NNP
cord-284409-xiyeceib	165	8	envelope	envelope	NN
cord-284409-xiyeceib	165	9	glycoprotein	glycoprotein	VBG
cord-284409-xiyeceib	165	10	Crystal	Crystal	NNP
cord-284409-xiyeceib	165	11	structure	structure	NN
cord-284409-xiyeceib	165	12	of	of	IN
cord-284409-xiyeceib	165	13	a	a	DT
cord-284409-xiyeceib	165	14	soluble	soluble	JJ
cord-284409-xiyeceib	165	15	cleaved	cleave	VBN
cord-284409-xiyeceib	165	16	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	165	17	envelope	envelope	NN
cord-284409-xiyeceib	165	18	trimer	trimer	NN
cord-284409-xiyeceib	165	19	Cryo	Cryo	NNP
cord-284409-xiyeceib	165	20	-	-	HYPH
cord-284409-xiyeceib	165	21	EM	EM	NNP
cord-284409-xiyeceib	165	22	structure	structure	NN
cord-284409-xiyeceib	165	23	of	of	IN
cord-284409-xiyeceib	165	24	a	a	DT
cord-284409-xiyeceib	165	25	fully	fully	RB
cord-284409-xiyeceib	165	26	glycosylated	glycosylated	JJ
cord-284409-xiyeceib	165	27	soluble	soluble	NN
cord-284409-xiyeceib	165	28	cleaved	cleave	VBN
cord-284409-xiyeceib	165	29	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	165	30	envelope	envelope	NN
cord-284409-xiyeceib	165	31	trimer	trimer	NN
cord-284409-xiyeceib	165	32	Viral	viral	JJ
cord-284409-xiyeceib	165	33	sequence	sequence	NN
cord-284409-xiyeceib	165	34	diversity	diversity	NN
cord-284409-xiyeceib	165	35	:	:	:
cord-284409-xiyeceib	165	36	challenges	challenge	NNS
cord-284409-xiyeceib	165	37	for	for	IN
cord-284409-xiyeceib	165	38	AIDS	AIDS	NNP
cord-284409-xiyeceib	165	39	vaccine	vaccine	NN
cord-284409-xiyeceib	165	40	designs	design	VBZ
cord-284409-xiyeceib	165	41	Antibody	antibody	NN
cord-284409-xiyeceib	165	42	neutralization	neutralization	NN
cord-284409-xiyeceib	165	43	and	and	CC
cord-284409-xiyeceib	165	44	escape	escape	NN
cord-284409-xiyeceib	165	45	by	by	IN
cord-284409-xiyeceib	165	46	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	165	47	Examination	Examination	NNP
cord-284409-xiyeceib	165	48	of	of	IN
cord-284409-xiyeceib	165	49	the	the	DT
cord-284409-xiyeceib	165	50	contributions	contribution	NNS
cord-284409-xiyeceib	165	51	of	of	IN
cord-284409-xiyeceib	165	52	size	size	NN
cord-284409-xiyeceib	165	53	and	and	CC
cord-284409-xiyeceib	165	54	avidity	avidity	NN
cord-284409-xiyeceib	165	55	to	to	IN
cord-284409-xiyeceib	165	56	the	the	DT
cord-284409-xiyeceib	165	57	neutralization	neutralization	NN
cord-284409-xiyeceib	165	58	mechanisms	mechanism	NNS
cord-284409-xiyeceib	165	59	of	of	IN
cord-284409-xiyeceib	165	60	the	the	DT
cord-284409-xiyeceib	165	61	anti	anti	JJ
cord-284409-xiyeceib	165	62	-	-	JJ
cord-284409-xiyeceib	165	63	HIV	HIV	NNP
cord-284409-xiyeceib	165	64	antibodies	antibody	NNS
cord-284409-xiyeceib	165	65	b12	b12	NN
cord-284409-xiyeceib	165	66	and	and	CC
cord-284409-xiyeceib	166	1	4E10	4e10	CD
cord-284409-xiyeceib	166	2	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	166	3	evades	evade	VBZ
cord-284409-xiyeceib	166	4	antibody	antibody	NN
cord-284409-xiyeceib	166	5	-	-	HYPH
cord-284409-xiyeceib	166	6	mediated	mediate	VBN
cord-284409-xiyeceib	166	7	neutralization	neutralization	NN
cord-284409-xiyeceib	166	8	through	through	IN
cord-284409-xiyeceib	166	9	conformational	conformational	JJ
cord-284409-xiyeceib	166	10	masking	masking	NN
cord-284409-xiyeceib	166	11	of	of	IN
cord-284409-xiyeceib	166	12	receptor	receptor	NN
cord-284409-xiyeceib	166	13	-	-	HYPH
cord-284409-xiyeceib	166	14	binding	bind	VBG
cord-284409-xiyeceib	166	15	sites	site	NNS
cord-284409-xiyeceib	166	16	HIV	HIV	NNP
cord-284409-xiyeceib	166	17	vaccine	vaccine	NN
cord-284409-xiyeceib	166	18	design	design	NN
cord-284409-xiyeceib	166	19	and	and	CC
cord-284409-xiyeceib	166	20	the	the	DT
cord-284409-xiyeceib	166	21	neutralizing	neutralize	VBG
cord-284409-xiyeceib	166	22	antibody	antibody	NN
cord-284409-xiyeceib	166	23	problem	problem	NN
cord-284409-xiyeceib	166	24	Extensive	extensive	JJ
cord-284409-xiyeceib	166	25	maturation	maturation	NN
cord-284409-xiyeceib	166	26	of	of	IN
cord-284409-xiyeceib	166	27	cross	cross	JJ
cord-284409-xiyeceib	166	28	-	-	JJ
cord-284409-xiyeceib	166	29	reactive	reactive	JJ
cord-284409-xiyeceib	166	30	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	166	31	neutralizing	neutralize	VBG
cord-284409-xiyeceib	166	32	antibodies	antibody	NNS
cord-284409-xiyeceib	166	33	but	but	CC
cord-284409-xiyeceib	166	34	not	not	RB
cord-284409-xiyeceib	166	35	of	of	IN
cord-284409-xiyeceib	166	36	neutralizing	neutralize	VBG
cord-284409-xiyeceib	166	37	antibodies	antibody	NNS
cord-284409-xiyeceib	166	38	against	against	IN
cord-284409-xiyeceib	166	39	the	the	DT
cord-284409-xiyeceib	166	40	SARS	SARS	NNP
cord-284409-xiyeceib	166	41	CoV	cov	NN
cord-284409-xiyeceib	166	42	,	,	,
cord-284409-xiyeceib	166	43	Nipah	Nipah	NNP
cord-284409-xiyeceib	166	44	and	and	CC
cord-284409-xiyeceib	166	45	Hendra	Hendra	NNP
cord-284409-xiyeceib	166	46	viruses	virus	NNS
cord-284409-xiyeceib	167	1	All	all	DT
cord-284409-xiyeceib	167	2	known	know	VBN
cord-284409-xiyeceib	167	3	cross	cross	NN
cord-284409-xiyeceib	167	4	reactive	reactive	JJ
cord-284409-xiyeceib	167	5	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	167	6	neutralizing	neutralize	VBG
cord-284409-xiyeceib	167	7	antibodies	antibody	NNS
cord-284409-xiyeceib	167	8	are	be	VBP
cord-284409-xiyeceib	167	9	highly	highly	RB
cord-284409-xiyeceib	167	10	divergent	divergent	JJ
cord-284409-xiyeceib	167	11	from	from	IN
cord-284409-xiyeceib	167	12	germline	germline	NN
cord-284409-xiyeceib	167	13	and	and	CC
cord-284409-xiyeceib	167	14	their	-PRON-	PRP$
cord-284409-xiyeceib	167	15	elicitation	elicitation	NN
cord-284409-xiyeceib	167	16	may	may	MD
cord-284409-xiyeceib	167	17	require	require	VB
cord-284409-xiyeceib	167	18	prolonged	prolonged	JJ
cord-284409-xiyeceib	167	19	periods	period	NNS
cord-284409-xiyeceib	167	20	of	of	IN
cord-284409-xiyeceib	167	21	time	time	NN
cord-284409-xiyeceib	167	22	Germline	Germline	NNP
cord-284409-xiyeceib	167	23	-	-	HYPH
cord-284409-xiyeceib	167	24	like	like	JJ
cord-284409-xiyeceib	167	25	predecessors	predecessor	NNS
cord-284409-xiyeceib	167	26	of	of	IN
cord-284409-xiyeceib	167	27	broadly	broadly	RB
cord-284409-xiyeceib	167	28	neutralizing	neutralize	VBG
cord-284409-xiyeceib	167	29	antibodies	antibody	NNS
cord-284409-xiyeceib	167	30	lack	lack	VBP
cord-284409-xiyeceib	167	31	measurable	measurable	JJ
cord-284409-xiyeceib	167	32	binding	binding	NN
cord-284409-xiyeceib	167	33	to	to	IN
cord-284409-xiyeceib	167	34	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	167	35	envelope	envelope	NN
cord-284409-xiyeceib	167	36	glycoproteins	glycoprotein	NNS
cord-284409-xiyeceib	167	37	:	:	:
cord-284409-xiyeceib	167	38	implications	implication	NNS
cord-284409-xiyeceib	167	39	for	for	IN
cord-284409-xiyeceib	167	40	evasion	evasion	NN
cord-284409-xiyeceib	167	41	of	of	IN
cord-284409-xiyeceib	167	42	immune	immune	JJ
cord-284409-xiyeceib	167	43	responses	response	NNS
cord-284409-xiyeceib	167	44	and	and	CC
cord-284409-xiyeceib	167	45	design	design	NN
cord-284409-xiyeceib	167	46	of	of	IN
cord-284409-xiyeceib	167	47	vaccine	vaccine	NN
cord-284409-xiyeceib	167	48	immunogens	immunogen	NNS
cord-284409-xiyeceib	167	49	Identification	identification	NN
cord-284409-xiyeceib	167	50	of	of	IN
cord-284409-xiyeceib	167	51	non	non	JJ
cord-284409-xiyeceib	167	52	-	-	JJ
cord-284409-xiyeceib	167	53	HIV	HIV	NNP
cord-284409-xiyeceib	167	54	immunogens	immunogen	NNS
cord-284409-xiyeceib	167	55	that	that	WDT
cord-284409-xiyeceib	167	56	bind	bind	VBP
cord-284409-xiyeceib	167	57	to	to	IN
cord-284409-xiyeceib	167	58	germline	germline	JJ
cord-284409-xiyeceib	167	59	b12	b12	NN
cord-284409-xiyeceib	167	60	predecessors	predecessor	NNS
cord-284409-xiyeceib	167	61	and	and	CC
cord-284409-xiyeceib	167	62	elicit	elicit	VB
cord-284409-xiyeceib	167	63	cross	cross	JJ
cord-284409-xiyeceib	167	64	-	-	JJ
cord-284409-xiyeceib	167	65	reactive	reactive	JJ
cord-284409-xiyeceib	167	66	neutralizing	neutralize	VBG
cord-284409-xiyeceib	167	67	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	167	68	antibodies	antibody	NNS
cord-284409-xiyeceib	167	69	Maturation	Maturation	NNP
cord-284409-xiyeceib	167	70	pathways	pathway	NNS
cord-284409-xiyeceib	167	71	of	of	IN
cord-284409-xiyeceib	167	72	cross	cross	JJ
cord-284409-xiyeceib	167	73	-	-	JJ
cord-284409-xiyeceib	167	74	reactive	reactive	JJ
cord-284409-xiyeceib	167	75	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	167	76	neutralizing	neutralize	VBG
cord-284409-xiyeceib	167	77	antibodies	antibody	NNS
cord-284409-xiyeceib	167	78	Therapeutic	therapeutic	JJ
cord-284409-xiyeceib	167	79	antibodies	antibody	NNS
cord-284409-xiyeceib	167	80	,	,	,
cord-284409-xiyeceib	167	81	vaccines	vaccine	NNS
cord-284409-xiyeceib	167	82	and	and	CC
cord-284409-xiyeceib	167	83	antibodyomes	antibodyomes	NNP
cord-284409-xiyeceib	167	84	Origin	Origin	NNP
cord-284409-xiyeceib	167	85	,	,	,
cord-284409-xiyeceib	167	86	diversity	diversity	NN
cord-284409-xiyeceib	167	87	,	,	,
cord-284409-xiyeceib	167	88	and	and	CC
cord-284409-xiyeceib	167	89	maturation	maturation	NN
cord-284409-xiyeceib	167	90	of	of	IN
cord-284409-xiyeceib	167	91	human	human	JJ
cord-284409-xiyeceib	167	92	antiviral	antiviral	JJ
cord-284409-xiyeceib	167	93	antibodies	antibody	NNS
cord-284409-xiyeceib	167	94	analyzed	analyze	VBN
cord-284409-xiyeceib	167	95	by	by	IN
cord-284409-xiyeceib	167	96	high	high	JJ
cord-284409-xiyeceib	167	97	-	-	HYPH
cord-284409-xiyeceib	167	98	throughput	throughput	NN
cord-284409-xiyeceib	167	99	sequencing	sequence	VBG
cord-284409-xiyeceib	167	100	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	167	101	neutralizing	neutralize	VBG
cord-284409-xiyeceib	167	102	antibodies	antibody	NNS
cord-284409-xiyeceib	167	103	:	:	:
cord-284409-xiyeceib	167	104	understanding	understand	VBG
cord-284409-xiyeceib	167	105	nature	nature	NN
cord-284409-xiyeceib	167	106	's	's	POS
cord-284409-xiyeceib	167	107	pathways	pathway	NNS
cord-284409-xiyeceib	168	1	Paradigm	paradigm	NN
cord-284409-xiyeceib	168	2	changes	change	NNS
cord-284409-xiyeceib	168	3	and	and	CC
cord-284409-xiyeceib	168	4	the	the	DT
cord-284409-xiyeceib	168	5	future	future	NN
cord-284409-xiyeceib	168	6	of	of	IN
cord-284409-xiyeceib	168	7	HIV	HIV	NNP
cord-284409-xiyeceib	168	8	vaccine	vaccine	NN
cord-284409-xiyeceib	168	9	research	research	NN
cord-284409-xiyeceib	168	10	:	:	:
cord-284409-xiyeceib	168	11	a	a	DT
cord-284409-xiyeceib	168	12	summary	summary	NN
cord-284409-xiyeceib	168	13	of	of	IN
cord-284409-xiyeceib	168	14	a	a	DT
cord-284409-xiyeceib	168	15	workshop	workshop	NN
cord-284409-xiyeceib	168	16	held	hold	VBN
cord-284409-xiyeceib	168	17	in	in	IN
cord-284409-xiyeceib	168	18	Baltimore	Baltimore	NNP
cord-284409-xiyeceib	168	19	on	on	IN
cord-284409-xiyeceib	168	20	20	20	CD
cord-284409-xiyeceib	168	21	Construction	construction	NN
cord-284409-xiyeceib	168	22	of	of	IN
cord-284409-xiyeceib	168	23	a	a	DT
cord-284409-xiyeceib	168	24	large	large	JJ
cord-284409-xiyeceib	168	25	naive	naive	JJ
cord-284409-xiyeceib	168	26	human	human	JJ
cord-284409-xiyeceib	168	27	phage	phage	NN
cord-284409-xiyeceib	168	28	-	-	HYPH
cord-284409-xiyeceib	168	29	displayed	display	VBN
cord-284409-xiyeceib	168	30	Fab	Fab	NNP
cord-284409-xiyeceib	168	31	library	library	NN
cord-284409-xiyeceib	168	32	through	through	IN
cord-284409-xiyeceib	168	33	one	one	CD
cord-284409-xiyeceib	168	34	-	-	HYPH
cord-284409-xiyeceib	168	35	step	step	NN
cord-284409-xiyeceib	168	36	cloning	clone	VBG
cord-284409-xiyeceib	168	37	Expressed	express	VBD
cord-284409-xiyeceib	168	38	antibody	antibody	NN
cord-284409-xiyeceib	168	39	repertoires	repertoire	NNS
cord-284409-xiyeceib	168	40	in	in	IN
cord-284409-xiyeceib	168	41	human	human	JJ
cord-284409-xiyeceib	168	42	cord	cord	NN
cord-284409-xiyeceib	168	43	blood	blood	NN
cord-284409-xiyeceib	168	44	cells	cell	NNS
cord-284409-xiyeceib	168	45	:	:	:
cord-284409-xiyeceib	168	46	454	454	CD
cord-284409-xiyeceib	168	47	sequencing	sequencing	NN
cord-284409-xiyeceib	168	48	and	and	CC
cord-284409-xiyeceib	168	49	IMGT	IMGT	NNP
cord-284409-xiyeceib	168	50	/	/	SYM
cord-284409-xiyeceib	168	51	HighV	HighV	NNP
cord-284409-xiyeceib	168	52	-	-	HYPH
cord-284409-xiyeceib	168	53	QUEST	quest	NN
cord-284409-xiyeceib	168	54	analysis	analysis	NN
cord-284409-xiyeceib	168	55	of	of	IN
cord-284409-xiyeceib	168	56	germline	germline	JJ
cord-284409-xiyeceib	168	57	gene	gene	NN
cord-284409-xiyeceib	168	58	usage	usage	NN
cord-284409-xiyeceib	168	59	,	,	,
cord-284409-xiyeceib	168	60	junctional	junctional	JJ
cord-284409-xiyeceib	168	61	diversity	diversity	NN
cord-284409-xiyeceib	168	62	,	,	,
cord-284409-xiyeceib	168	63	and	and	CC
cord-284409-xiyeceib	168	64	somatic	somatic	JJ
cord-284409-xiyeceib	168	65	mutations	mutation	NNS
cord-284409-xiyeceib	168	66	IMGT((R	IMGT((R	NNP
cord-284409-xiyeceib	168	67	)	)	-RRB-
cord-284409-xiyeceib	168	68	)	)	-RRB-
cord-284409-xiyeceib	168	69	tools	tool	NNS
cord-284409-xiyeceib	168	70	for	for	IN
cord-284409-xiyeceib	168	71	the	the	DT
cord-284409-xiyeceib	168	72	nucleotide	nucleotide	JJ
cord-284409-xiyeceib	168	73	analysis	analysis	NN
cord-284409-xiyeceib	168	74	of	of	IN
cord-284409-xiyeceib	168	75	immunoglobulin	immunoglobulin	NN
cord-284409-xiyeceib	168	76	(	(	-LRB-
cord-284409-xiyeceib	168	77	IG	IG	NNP
cord-284409-xiyeceib	168	78	)	)	-RRB-
cord-284409-xiyeceib	168	79	and	and	CC
cord-284409-xiyeceib	168	80	T	T	NNP
cord-284409-xiyeceib	168	81	cell	cell	NN
cord-284409-xiyeceib	168	82	receptor	receptor	NN
cord-284409-xiyeceib	168	83	(	(	-LRB-
cord-284409-xiyeceib	168	84	TR	tr	NN
cord-284409-xiyeceib	168	85	)	)	-RRB-
cord-284409-xiyeceib	168	86	BioEdit	bioedit	NN
cord-284409-xiyeceib	168	87	:	:	:
cord-284409-xiyeceib	168	88	a	a	DT
cord-284409-xiyeceib	168	89	user	user	NN
cord-284409-xiyeceib	168	90	-	-	HYPH
cord-284409-xiyeceib	168	91	friendly	friendly	JJ
cord-284409-xiyeceib	168	92	biological	biological	JJ
cord-284409-xiyeceib	168	93	sequence	sequence	NN
cord-284409-xiyeceib	168	94	alignment	alignment	NN
cord-284409-xiyeceib	168	95	editor	editor	NN
cord-284409-xiyeceib	168	96	and	and	CC
cord-284409-xiyeceib	168	97	analysis	analysis	NN
cord-284409-xiyeceib	168	98	program	program	NN
cord-284409-xiyeceib	168	99	for	for	IN
cord-284409-xiyeceib	168	100	Windows	Windows	NNP
cord-284409-xiyeceib	168	101	95/98	95/98	CD
cord-284409-xiyeceib	168	102	/	/	SYM
cord-284409-xiyeceib	168	103	NT	NT	NNP
cord-284409-xiyeceib	168	104	phyloXML	phyloXML	NNP
cord-284409-xiyeceib	168	105	:	:	:
cord-284409-xiyeceib	168	106	XML	xml	NN
cord-284409-xiyeceib	168	107	for	for	IN
cord-284409-xiyeceib	168	108	evolutionary	evolutionary	JJ
cord-284409-xiyeceib	168	109	biology	biology	NN
cord-284409-xiyeceib	168	110	and	and	CC
cord-284409-xiyeceib	168	111	comparative	comparative	JJ
cord-284409-xiyeceib	168	112	genomics	genomic	NNS
cord-284409-xiyeceib	169	1	Focused	focused	JJ
cord-284409-xiyeceib	169	2	evolution	evolution	NN
cord-284409-xiyeceib	169	3	of	of	IN
cord-284409-xiyeceib	169	4	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	169	5	neutralizing	neutralize	VBG
cord-284409-xiyeceib	169	6	antibodies	antibody	NNS
cord-284409-xiyeceib	169	7	revealed	reveal	VBN
cord-284409-xiyeceib	169	8	by	by	IN
cord-284409-xiyeceib	169	9	structures	structure	NNS
cord-284409-xiyeceib	169	10	and	and	CC
cord-284409-xiyeceib	169	11	deep	deep	JJ
cord-284409-xiyeceib	169	12	sequencing	sequencing	NN
cord-284409-xiyeceib	169	13	Sequence	sequence	NN
cord-284409-xiyeceib	169	14	and	and	CC
cord-284409-xiyeceib	169	15	structural	structural	JJ
cord-284409-xiyeceib	169	16	convergence	convergence	NN
cord-284409-xiyeceib	169	17	of	of	IN
cord-284409-xiyeceib	169	18	broad	broad	JJ
cord-284409-xiyeceib	169	19	and	and	CC
cord-284409-xiyeceib	169	20	potent	potent	JJ
cord-284409-xiyeceib	169	21	HIV	HIV	NNP
cord-284409-xiyeceib	169	22	antibodies	antibody	NNS
cord-284409-xiyeceib	169	23	that	that	WDT
cord-284409-xiyeceib	169	24	mimic	mimic	VBP
cord-284409-xiyeceib	169	25	CD4	CD4	NNP
cord-284409-xiyeceib	169	26	binding	bind	VBG
cord-284409-xiyeceib	169	27	Immunologic	immunologic	JJ
cord-284409-xiyeceib	169	28	basis	basis	NN
cord-284409-xiyeceib	169	29	for	for	IN
cord-284409-xiyeceib	169	30	long	long	JJ
cord-284409-xiyeceib	169	31	HCDR3s	hcdr3s	CD
cord-284409-xiyeceib	169	32	in	in	IN
cord-284409-xiyeceib	169	33	broadly	broadly	RB
cord-284409-xiyeceib	169	34	neutralizing	neutralize	VBG
cord-284409-xiyeceib	169	35	antibodies	antibody	NNS
cord-284409-xiyeceib	169	36	against	against	IN
cord-284409-xiyeceib	169	37	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	169	38	Recombinant	Recombinant	NNP
cord-284409-xiyeceib	169	39	HIV	HIV	NNP
cord-284409-xiyeceib	169	40	envelope	envelope	NN
cord-284409-xiyeceib	169	41	proteins	protein	NNS
cord-284409-xiyeceib	169	42	fail	fail	VBP
cord-284409-xiyeceib	169	43	to	to	TO
cord-284409-xiyeceib	169	44	engage	engage	VB
cord-284409-xiyeceib	169	45	germline	germline	JJ
cord-284409-xiyeceib	169	46	versions	version	NNS
cord-284409-xiyeceib	169	47	of	of	IN
cord-284409-xiyeceib	169	48	anti	anti	JJ
cord-284409-xiyeceib	169	49	-	-	JJ
cord-284409-xiyeceib	169	50	CD4bs	cd4bs	JJ
cord-284409-xiyeceib	169	51	bNAbs	bnabs	NN
cord-284409-xiyeceib	169	52	Engineering	Engineering	NNP
cord-284409-xiyeceib	169	53	HIV	HIV	NNP
cord-284409-xiyeceib	169	54	envelope	envelope	NN
cord-284409-xiyeceib	169	55	protein	protein	NN
cord-284409-xiyeceib	169	56	to	to	TO
cord-284409-xiyeceib	169	57	activate	activate	VB
cord-284409-xiyeceib	169	58	germline	germline	NN
cord-284409-xiyeceib	169	59	B	b	NN
cord-284409-xiyeceib	169	60	cell	cell	NN
cord-284409-xiyeceib	169	61	receptors	receptor	NNS
cord-284409-xiyeceib	169	62	of	of	IN
cord-284409-xiyeceib	170	1	broadly	broadly	RB
cord-284409-xiyeceib	170	2	neutralizing	neutralize	VBG
cord-284409-xiyeceib	170	3	anti	anti	JJ
cord-284409-xiyeceib	170	4	-	-	JJ
cord-284409-xiyeceib	170	5	CD4	CD4	NNP
cord-284409-xiyeceib	170	6	binding	bind	VBG
cord-284409-xiyeceib	170	7	site	site	NN
cord-284409-xiyeceib	170	8	antibodies	antibody	NNS
cord-284409-xiyeceib	171	1	Diverse	diverse	JJ
cord-284409-xiyeceib	171	2	recombinant	recombinant	JJ
cord-284409-xiyeceib	171	3	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	171	4	Envs	Envs	NNP
cord-284409-xiyeceib	171	5	fail	fail	VB
cord-284409-xiyeceib	171	6	to	to	TO
cord-284409-xiyeceib	171	7	activate	activate	VB
cord-284409-xiyeceib	171	8	B	b	NN
cord-284409-xiyeceib	171	9	cells	cell	NNS
cord-284409-xiyeceib	171	10	expressing	express	VBG
cord-284409-xiyeceib	171	11	the	the	DT
cord-284409-xiyeceib	171	12	germline	germline	NN
cord-284409-xiyeceib	171	13	B	b	NN
cord-284409-xiyeceib	171	14	cell	cell	NN
cord-284409-xiyeceib	171	15	receptors	receptor	NNS
cord-284409-xiyeceib	171	16	of	of	IN
cord-284409-xiyeceib	171	17	the	the	DT
cord-284409-xiyeceib	171	18	broadly	broadly	RB
cord-284409-xiyeceib	171	19	neutralizing	neutralize	VBG
cord-284409-xiyeceib	171	20	anti	anti	JJ
cord-284409-xiyeceib	171	21	-	-	JJ
cord-284409-xiyeceib	171	22	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	171	23	antibodies	antibody	NNS
cord-284409-xiyeceib	171	24	PG9	PG9	NNP
cord-284409-xiyeceib	171	25	and	and	CC
cord-284409-xiyeceib	171	26	447	447	CD
cord-284409-xiyeceib	171	27	-	-	HYPH
cord-284409-xiyeceib	171	28	52D	52d	CD
cord-284409-xiyeceib	171	29	Co	co	NN
cord-284409-xiyeceib	171	30	-	-	NN
cord-284409-xiyeceib	171	31	evolution	evolution	NN
cord-284409-xiyeceib	171	32	of	of	IN
cord-284409-xiyeceib	171	33	a	a	DT
cord-284409-xiyeceib	171	34	broadly	broadly	RB
cord-284409-xiyeceib	171	35	neutralizing	neutralize	VBG
cord-284409-xiyeceib	171	36	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	171	37	antibody	antibody	NN
cord-284409-xiyeceib	171	38	and	and	CC
cord-284409-xiyeceib	171	39	founder	founder	NN
cord-284409-xiyeceib	171	40	virus	virus	NN
cord-284409-xiyeceib	171	41	Developmental	developmental	JJ
cord-284409-xiyeceib	171	42	pathway	pathway	NN
cord-284409-xiyeceib	171	43	for	for	IN
cord-284409-xiyeceib	171	44	potent	potent	JJ
cord-284409-xiyeceib	171	45	V1V2-directed	v1v2-directe	VBN
cord-284409-xiyeceib	171	46	HIV	HIV	NNP
cord-284409-xiyeceib	171	47	-	-	HYPH
cord-284409-xiyeceib	171	48	neutralizing	neutralize	VBG
cord-284409-xiyeceib	171	49	antibodies	antibody	NNS
cord-284409-xiyeceib	171	50	Rational	rational	JJ
cord-284409-xiyeceib	171	51	HIV	HIV	NNP
cord-284409-xiyeceib	171	52	immunogen	immunogen	NN
cord-284409-xiyeceib	171	53	design	design	NN
cord-284409-xiyeceib	171	54	to	to	TO
cord-284409-xiyeceib	171	55	target	target	VB
cord-284409-xiyeceib	171	56	specific	specific	JJ
cord-284409-xiyeceib	171	57	germline	germline	NN
cord-284409-xiyeceib	171	58	B	b	NN
cord-284409-xiyeceib	171	59	cell	cell	NN
cord-284409-xiyeceib	171	60	receptors	receptor	NNS
cord-284409-xiyeceib	171	61	Somatic	somatic	JJ
cord-284409-xiyeceib	171	62	mutations	mutation	NNS
cord-284409-xiyeceib	171	63	of	of	IN
cord-284409-xiyeceib	171	64	the	the	DT
cord-284409-xiyeceib	171	65	immunoglobulin	immunoglobulin	NN
cord-284409-xiyeceib	171	66	framework	framework	NN
cord-284409-xiyeceib	171	67	are	be	VBP
cord-284409-xiyeceib	171	68	generally	generally	RB
cord-284409-xiyeceib	171	69	required	require	VBN
cord-284409-xiyeceib	171	70	for	for	IN
cord-284409-xiyeceib	171	71	broad	broad	JJ
cord-284409-xiyeceib	171	72	and	and	CC
cord-284409-xiyeceib	171	73	potent	potent	JJ
cord-284409-xiyeceib	171	74	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	171	75	neutralization	neutralization	NN
cord-284409-xiyeceib	171	76	Multidonor	Multidonor	NNP
cord-284409-xiyeceib	171	77	analysis	analysis	NN
cord-284409-xiyeceib	171	78	reveals	reveal	VBZ
cord-284409-xiyeceib	171	79	structural	structural	JJ
cord-284409-xiyeceib	171	80	elements	element	NNS
cord-284409-xiyeceib	171	81	,	,	,
cord-284409-xiyeceib	171	82	genetic	genetic	JJ
cord-284409-xiyeceib	171	83	determinants	determinant	NNS
cord-284409-xiyeceib	171	84	,	,	,
cord-284409-xiyeceib	171	85	and	and	CC
cord-284409-xiyeceib	171	86	maturation	maturation	NN
cord-284409-xiyeceib	171	87	pathway	pathway	NN
cord-284409-xiyeceib	171	88	for	for	IN
cord-284409-xiyeceib	171	89	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	171	90	neutralization	neutralization	NN
cord-284409-xiyeceib	171	91	by	by	IN
cord-284409-xiyeceib	171	92	VRC01-class	VRC01-class	NNP
cord-284409-xiyeceib	171	93	antibodies	antibody	NNS
cord-284409-xiyeceib	171	94	Mining	Mining	NNP
cord-284409-xiyeceib	171	95	the	the	DT
cord-284409-xiyeceib	171	96	antibodyome	antibodyome	NN
cord-284409-xiyeceib	171	97	for	for	IN
cord-284409-xiyeceib	171	98	HIV-1-neutralizing	hiv-1-neutralize	VBG
cord-284409-xiyeceib	171	99	antibodies	antibody	NNS
cord-284409-xiyeceib	171	100	with	with	IN
cord-284409-xiyeceib	171	101	next	next	JJ
cord-284409-xiyeceib	171	102	-	-	HYPH
cord-284409-xiyeceib	171	103	generation	generation	NN
cord-284409-xiyeceib	171	104	sequencing	sequencing	NN
cord-284409-xiyeceib	171	105	and	and	CC
cord-284409-xiyeceib	171	106	phylogenetic	phylogenetic	JJ
cord-284409-xiyeceib	171	107	pairing	pairing	NN
cord-284409-xiyeceib	171	108	of	of	IN
cord-284409-xiyeceib	171	109	heavy	heavy	JJ
cord-284409-xiyeceib	171	110	/	/	SYM
cord-284409-xiyeceib	171	111	light	light	NN
cord-284409-xiyeceib	171	112	chains	chain	NNS
cord-284409-xiyeceib	171	113	De	de	FW
cord-284409-xiyeceib	171	114	novo	novo	NN
cord-284409-xiyeceib	171	115	identification	identification	NN
cord-284409-xiyeceib	171	116	of	of	IN
cord-284409-xiyeceib	171	117	VRC01	VRC01	NNP
cord-284409-xiyeceib	171	118	class	class	NN
cord-284409-xiyeceib	171	119	HIV-1-neutralizing	hiv-1-neutralize	VBG
cord-284409-xiyeceib	171	120	antibodies	antibody	NNS
cord-284409-xiyeceib	171	121	by	by	IN
cord-284409-xiyeceib	171	122	next	next	JJ
cord-284409-xiyeceib	171	123	-	-	HYPH
cord-284409-xiyeceib	171	124	generation	generation	NN
cord-284409-xiyeceib	171	125	sequencing	sequencing	NN
cord-284409-xiyeceib	171	126	of	of	IN
cord-284409-xiyeceib	171	127	B	b	NN
cord-284409-xiyeceib	171	128	-	-	HYPH
cord-284409-xiyeceib	171	129	cell	cell	NN
cord-284409-xiyeceib	171	130	transcripts	transcript	NNS
cord-284409-xiyeceib	172	1	The	the	DT
cord-284409-xiyeceib	172	2	effects	effect	NNS
cord-284409-xiyeceib	172	3	of	of	IN
cord-284409-xiyeceib	172	4	somatic	somatic	JJ
cord-284409-xiyeceib	172	5	hypermutation	hypermutation	NN
cord-284409-xiyeceib	172	6	on	on	IN
cord-284409-xiyeceib	172	7	neutralization	neutralization	NN
cord-284409-xiyeceib	172	8	and	and	CC
cord-284409-xiyeceib	172	9	binding	bind	VBG
cord-284409-xiyeceib	172	10	in	in	IN
cord-284409-xiyeceib	172	11	the	the	DT
cord-284409-xiyeceib	172	12	PGT121	PGT121	NNP
cord-284409-xiyeceib	172	13	family	family	NN
cord-284409-xiyeceib	172	14	of	of	IN
cord-284409-xiyeceib	172	15	broadly	broadly	RB
cord-284409-xiyeceib	172	16	neutralizing	neutralize	VBG
cord-284409-xiyeceib	172	17	HIV	HIV	NNP
cord-284409-xiyeceib	172	18	antibodies	antibody	NNS
cord-284409-xiyeceib	172	19	Cross	Cross	NNP
cord-284409-xiyeceib	172	20	-	-	JJ
cord-284409-xiyeceib	172	21	reactive	reactive	JJ
cord-284409-xiyeceib	172	22	HIV-1-neutralizing	hiv-1-neutralize	VBG
cord-284409-xiyeceib	172	23	human	human	JJ
cord-284409-xiyeceib	172	24	monoclonal	monoclonal	JJ
cord-284409-xiyeceib	172	25	antibodies	antibody	NNS
cord-284409-xiyeceib	172	26	identified	identify	VBN
cord-284409-xiyeceib	172	27	from	from	IN
cord-284409-xiyeceib	172	28	a	a	DT
cord-284409-xiyeceib	172	29	patient	patient	NN
cord-284409-xiyeceib	172	30	with	with	IN
cord-284409-xiyeceib	172	31	2F5-like	2f5-like	CD
cord-284409-xiyeceib	172	32	antibodies	antibody	NNS
cord-284409-xiyeceib	172	33	Structural	structural	JJ
cord-284409-xiyeceib	172	34	basis	basis	NN
cord-284409-xiyeceib	172	35	for	for	IN
cord-284409-xiyeceib	172	36	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	172	37	neutralization	neutralization	NN
cord-284409-xiyeceib	172	38	by	by	IN
cord-284409-xiyeceib	172	39	2F5-like	2f5-like	CD
cord-284409-xiyeceib	172	40	antibodies	antibody	NNS
cord-284409-xiyeceib	172	41	m66	m66	NN
cord-284409-xiyeceib	172	42	and	and	CC
cord-284409-xiyeceib	172	43	m66.6	m66.6	DT
cord-284409-xiyeceib	172	44	Early	early	JJ
cord-284409-xiyeceib	172	45	development	development	NN
cord-284409-xiyeceib	172	46	of	of	IN
cord-284409-xiyeceib	172	47	broadly	broadly	RB
cord-284409-xiyeceib	172	48	neutralizing	neutralize	VBG
cord-284409-xiyeceib	172	49	antibodies	antibody	NNS
cord-284409-xiyeceib	172	50	in	in	IN
cord-284409-xiyeceib	172	51	HIV-1-infected	hiv-1-infecte	VBN
cord-284409-xiyeceib	172	52	infants	infant	NNS
cord-284409-xiyeceib	173	1	Precise	precise	JJ
cord-284409-xiyeceib	173	2	determination	determination	NN
cord-284409-xiyeceib	173	3	of	of	IN
cord-284409-xiyeceib	173	4	the	the	DT
cord-284409-xiyeceib	173	5	diversity	diversity	NN
cord-284409-xiyeceib	173	6	of	of	IN
cord-284409-xiyeceib	173	7	a	a	DT
cord-284409-xiyeceib	173	8	combinatorial	combinatorial	JJ
cord-284409-xiyeceib	173	9	antibody	antibody	NN
cord-284409-xiyeceib	173	10	library	library	NN
cord-284409-xiyeceib	173	11	gives	give	VBZ
cord-284409-xiyeceib	173	12	insight	insight	NN
cord-284409-xiyeceib	173	13	into	into	IN
cord-284409-xiyeceib	173	14	the	the	DT
cord-284409-xiyeceib	173	15	human	human	JJ
cord-284409-xiyeceib	173	16	immunoglobulin	immunoglobulin	NN
cord-284409-xiyeceib	173	17	repertoire	repertoire	NN
cord-284409-xiyeceib	173	18	Junctional	Junctional	NNP
cord-284409-xiyeceib	173	19	amino	amino	JJ
cord-284409-xiyeceib	173	20	acids	acid	NNS
cord-284409-xiyeceib	173	21	determine	determine	VBP
cord-284409-xiyeceib	173	22	the	the	DT
cord-284409-xiyeceib	173	23	maturation	maturation	NN
cord-284409-xiyeceib	173	24	pathway	pathway	NN
cord-284409-xiyeceib	173	25	of	of	IN
cord-284409-xiyeceib	173	26	an	an	DT
cord-284409-xiyeceib	173	27	antibody	antibody	NN
cord-284409-xiyeceib	173	28	Structural	structural	JJ
cord-284409-xiyeceib	173	29	basis	basis	NN
cord-284409-xiyeceib	173	30	for	for	IN
cord-284409-xiyeceib	173	31	germ	germ	NN
cord-284409-xiyeceib	173	32	-	-	HYPH
cord-284409-xiyeceib	173	33	line	line	NN
cord-284409-xiyeceib	173	34	gene	gene	NN
cord-284409-xiyeceib	173	35	usage	usage	NN
cord-284409-xiyeceib	173	36	of	of	IN
cord-284409-xiyeceib	173	37	a	a	DT
cord-284409-xiyeceib	173	38	potent	potent	JJ
cord-284409-xiyeceib	173	39	class	class	NN
cord-284409-xiyeceib	173	40	of	of	IN
cord-284409-xiyeceib	173	41	antibodies	antibody	NNS
cord-284409-xiyeceib	173	42	targeting	target	VBG
cord-284409-xiyeceib	173	43	the	the	DT
cord-284409-xiyeceib	173	44	CD4-binding	cd4-binding	NN
cord-284409-xiyeceib	173	45	site	site	NN
cord-284409-xiyeceib	173	46	of	of	IN
cord-284409-xiyeceib	173	47	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	173	48	gp120	gp120	NNP
cord-284409-xiyeceib	173	49	Forced	forced	JJ
cord-284409-xiyeceib	173	50	usage	usage	NN
cord-284409-xiyeceib	173	51	of	of	IN
cord-284409-xiyeceib	173	52	positively	positively	RB
cord-284409-xiyeceib	173	53	charged	charge	VBN
cord-284409-xiyeceib	173	54	amino	amino	NN
cord-284409-xiyeceib	173	55	acids	acid	NNS
cord-284409-xiyeceib	173	56	in	in	IN
cord-284409-xiyeceib	173	57	immunoglobulin	immunoglobulin	NN
cord-284409-xiyeceib	173	58	CDR	CDR	NNP
cord-284409-xiyeceib	173	59	-	-	HYPH
cord-284409-xiyeceib	173	60	H3	H3	NNP
cord-284409-xiyeceib	173	61	impairs	impair	VBZ
cord-284409-xiyeceib	173	62	B	b	NN
cord-284409-xiyeceib	173	63	cell	cell	NN
cord-284409-xiyeceib	173	64	development	development	NN
cord-284409-xiyeceib	173	65	and	and	CC
cord-284409-xiyeceib	173	66	antibody	antibody	NN
cord-284409-xiyeceib	173	67	production	production	NN
cord-284409-xiyeceib	173	68	Preferential	preferential	JJ
cord-284409-xiyeceib	173	69	use	use	NN
cord-284409-xiyeceib	173	70	of	of	IN
cord-284409-xiyeceib	173	71	DH	DH	NNP
cord-284409-xiyeceib	173	72	reading	reading	NN
cord-284409-xiyeceib	173	73	frame	frame	NN
cord-284409-xiyeceib	173	74	2	2	CD
cord-284409-xiyeceib	173	75	alters	alter	VBZ
cord-284409-xiyeceib	173	76	B	b	NN
cord-284409-xiyeceib	173	77	cell	cell	NN
cord-284409-xiyeceib	173	78	development	development	NN
cord-284409-xiyeceib	173	79	and	and	CC
cord-284409-xiyeceib	173	80	antigen	antigen	NN
cord-284409-xiyeceib	173	81	-	-	HYPH
cord-284409-xiyeceib	173	82	specific	specific	JJ
cord-284409-xiyeceib	173	83	antibody	antibody	NN
cord-284409-xiyeceib	173	84	production	production	NN
cord-284409-xiyeceib	173	85	B	b	NN
cord-284409-xiyeceib	173	86	cell	cell	NN
cord-284409-xiyeceib	173	87	development	development	NN
cord-284409-xiyeceib	173	88	regulated	regulate	VBN
cord-284409-xiyeceib	173	89	by	by	IN
cord-284409-xiyeceib	173	90	gene	gene	NN
cord-284409-xiyeceib	173	91	rearrangement	rearrangement	NN
cord-284409-xiyeceib	173	92	:	:	:
cord-284409-xiyeceib	174	1	arrest	arrest	NN
cord-284409-xiyeceib	174	2	of	of	IN
cord-284409-xiyeceib	174	3	maturation	maturation	NN
cord-284409-xiyeceib	174	4	by	by	IN
cord-284409-xiyeceib	174	5	membrane	membrane	NN
cord-284409-xiyeceib	174	6	-	-	HYPH
cord-284409-xiyeceib	174	7	bound	bind	VBN
cord-284409-xiyeceib	174	8	D	d	NN
cord-284409-xiyeceib	174	9	mu	mu	NN
cord-284409-xiyeceib	174	10	protein	protein	NN
cord-284409-xiyeceib	174	11	and	and	CC
cord-284409-xiyeceib	174	12	selection	selection	NN
cord-284409-xiyeceib	174	13	of	of	IN
cord-284409-xiyeceib	174	14	DH	DH	NNP
cord-284409-xiyeceib	174	15	element	element	NN
cord-284409-xiyeceib	174	16	reading	reading	NN
cord-284409-xiyeceib	174	17	frames	frame	VBZ
cord-284409-xiyeceib	174	18	The	the	DT
cord-284409-xiyeceib	174	19	restricted	restricted	JJ
cord-284409-xiyeceib	174	20	DH	dh	NN
cord-284409-xiyeceib	174	21	gene	gene	NN
cord-284409-xiyeceib	174	22	reading	reading	NN
cord-284409-xiyeceib	174	23	frame	frame	NN
cord-284409-xiyeceib	174	24	usage	usage	NN
cord-284409-xiyeceib	174	25	in	in	IN
cord-284409-xiyeceib	174	26	the	the	DT
cord-284409-xiyeceib	174	27	expressed	express	VBN
cord-284409-xiyeceib	174	28	human	human	JJ
cord-284409-xiyeceib	174	29	antibody	antibody	NN
cord-284409-xiyeceib	174	30	repertoire	repertoire	NN
cord-284409-xiyeceib	174	31	is	be	VBZ
cord-284409-xiyeceib	174	32	selected	select	VBN
cord-284409-xiyeceib	174	33	based	base	VBN
cord-284409-xiyeceib	174	34	upon	upon	IN
cord-284409-xiyeceib	174	35	its	-PRON-	PRP$
cord-284409-xiyeceib	174	36	amino	amino	NN
cord-284409-xiyeceib	174	37	acid	acid	NN
cord-284409-xiyeceib	174	38	content	content	NN
cord-284409-xiyeceib	174	39	Regulation	regulation	NN
cord-284409-xiyeceib	174	40	of	of	IN
cord-284409-xiyeceib	174	41	repertoire	repertoire	NN
cord-284409-xiyeceib	174	42	development	development	NN
cord-284409-xiyeceib	174	43	through	through	IN
cord-284409-xiyeceib	174	44	genetic	genetic	JJ
cord-284409-xiyeceib	174	45	control	control	NN
cord-284409-xiyeceib	174	46	of	of	IN
cord-284409-xiyeceib	174	47	DH	DH	NNP
cord-284409-xiyeceib	174	48	reading	reading	NN
cord-284409-xiyeceib	174	49	frame	frame	NN
cord-284409-xiyeceib	174	50	preference	preference	NN
cord-284409-xiyeceib	175	1	The	the	DT
cord-284409-xiyeceib	175	2	promise	promise	NN
cord-284409-xiyeceib	175	3	and	and	CC
cord-284409-xiyeceib	175	4	challenge	challenge	NN
cord-284409-xiyeceib	175	5	of	of	IN
cord-284409-xiyeceib	175	6	high	high	JJ
cord-284409-xiyeceib	175	7	-	-	HYPH
cord-284409-xiyeceib	175	8	throughput	throughput	NN
cord-284409-xiyeceib	175	9	sequencing	sequencing	NN
cord-284409-xiyeceib	175	10	of	of	IN
cord-284409-xiyeceib	175	11	the	the	DT
cord-284409-xiyeceib	175	12	antibody	antibody	NN
cord-284409-xiyeceib	175	13	repertoire	repertoire	NN
cord-284409-xiyeceib	175	14	B	b	NN
cord-284409-xiyeceib	175	15	-	-	HYPH
cord-284409-xiyeceib	175	16	cell	cell	NN
cord-284409-xiyeceib	175	17	-	-	HYPH
cord-284409-xiyeceib	175	18	lineage	lineage	NN
cord-284409-xiyeceib	175	19	immunogen	immunogen	NN
cord-284409-xiyeceib	175	20	design	design	NN
cord-284409-xiyeceib	175	21	in	in	IN
cord-284409-xiyeceib	175	22	vaccine	vaccine	NN
cord-284409-xiyeceib	175	23	development	development	NN
cord-284409-xiyeceib	175	24	with	with	IN
cord-284409-xiyeceib	175	25	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	175	26	as	as	IN
cord-284409-xiyeceib	175	27	a	a	DT
cord-284409-xiyeceib	175	28	case	case	NN
cord-284409-xiyeceib	175	29	study	study	NN
cord-284409-xiyeceib	175	30	Immunogen	Immunogen	NNP
cord-284409-xiyeceib	175	31	design	design	NN
cord-284409-xiyeceib	175	32	for	for	IN
cord-284409-xiyeceib	175	33	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	175	34	and	and	CC
cord-284409-xiyeceib	175	35	influenza	influenza	NN
cord-284409-xiyeceib	175	36	Recognition	Recognition	NNP
cord-284409-xiyeceib	175	37	of	of	IN
cord-284409-xiyeceib	175	38	synthetic	synthetic	JJ
cord-284409-xiyeceib	175	39	glycopeptides	glycopeptide	NNS
cord-284409-xiyeceib	175	40	by	by	IN
cord-284409-xiyeceib	175	41	HIV-1	HIV-1	NNP
cord-284409-xiyeceib	175	42	broadly	broadly	RB
cord-284409-xiyeceib	175	43	neutralizing	neutralize	VBG
cord-284409-xiyeceib	175	44	antibodies	antibody	NNS
cord-284409-xiyeceib	175	45	and	and	CC
cord-284409-xiyeceib	175	46	their	-PRON-	PRP$
cord-284409-xiyeceib	175	47	unmutated	unmutated	JJ
cord-284409-xiyeceib	175	48	ancestors	ancestor	NNS
cord-284409-xiyeceib	175	49	content	content	JJ
cord-284409-xiyeceib	175	50	of	of	IN
cord-284409-xiyeceib	175	51	this	this	DT
cord-284409-xiyeceib	175	52	publication	publication	NN
cord-284409-xiyeceib	175	53	does	do	VBZ
cord-284409-xiyeceib	175	54	not	not	RB
cord-284409-xiyeceib	175	55	necessarily	necessarily	RB
cord-284409-xiyeceib	175	56	reflect	reflect	VB
cord-284409-xiyeceib	175	57	the	the	DT
cord-284409-xiyeceib	175	58	views	view	NNS
cord-284409-xiyeceib	175	59	or	or	CC
cord-284409-xiyeceib	175	60	policies	policy	NNS
cord-284409-xiyeceib	175	61	of	of	IN
cord-284409-xiyeceib	175	62	the	the	DT
cord-284409-xiyeceib	175	63	Department	Department	NNP
cord-284409-xiyeceib	175	64	of	of	IN
cord-284409-xiyeceib	175	65	Health	Health	NNP
cord-284409-xiyeceib	175	66	and	and	CC
cord-284409-xiyeceib	175	67	Human	Human	NNP
cord-284409-xiyeceib	175	68	Services	Services	NNPS
cord-284409-xiyeceib	175	69	,	,	,
cord-284409-xiyeceib	175	70	nor	nor	CC
cord-284409-xiyeceib	175	71	does	do	VBZ
cord-284409-xiyeceib	175	72	the	the	DT
cord-284409-xiyeceib	175	73	mention	mention	NN
cord-284409-xiyeceib	175	74	of	of	IN
cord-284409-xiyeceib	175	75	trade	trade	NN
cord-284409-xiyeceib	175	76	names	name	NNS
cord-284409-xiyeceib	175	77	,	,	,
cord-284409-xiyeceib	175	78	commercial	commercial	JJ
cord-284409-xiyeceib	175	79	products	product	NNS
cord-284409-xiyeceib	175	80	,	,	,
cord-284409-xiyeceib	175	81	or	or	CC
cord-284409-xiyeceib	175	82	organizations	organization	NNS
cord-284409-xiyeceib	175	83	imply	imply	VBP
cord-284409-xiyeceib	175	84	endorsement	endorsement	NN
cord-284409-xiyeceib	175	85	by	by	IN
cord-284409-xiyeceib	175	86	the	the	DT
cord-284409-xiyeceib	175	87	U.S.	U.S.	NNP
cord-284409-xiyeceib	175	88	Government	Government	NNP
cord-284409-xiyeceib	175	89	.	.	.
cord-284409-xiyeceib	176	1	The	the	DT
cord-284409-xiyeceib	176	2	Guest	Guest	NNP
cord-284409-xiyeceib	176	3	Associate	Associate	NNP
cord-284409-xiyeceib	176	4	Editor	Editor	NNP
cord-284409-xiyeceib	176	5	Marc	Marc	NNP
cord-284409-xiyeceib	176	6	H.	H.	NNP
cord-284409-xiyeceib	176	7	V.	V.	NNP
cord-284409-xiyeceib	176	8	Van	Van	NNP
cord-284409-xiyeceib	176	9	Regenmortel	Regenmortel	NNP
cord-284409-xiyeceib	176	10	declares	declare	VBZ
cord-284409-xiyeceib	176	11	that	that	IN
cord-284409-xiyeceib	176	12	,	,	,
cord-284409-xiyeceib	176	13	despite	despite	IN
cord-284409-xiyeceib	176	14	having	have	VBG
cord-284409-xiyeceib	176	15	collaborated	collaborate	VBN
cord-284409-xiyeceib	176	16	with	with	IN
cord-284409-xiyeceib	176	17	the	the	DT
cord-284409-xiyeceib	176	18	author	author	NN
cord-284409-xiyeceib	176	19	Dimiter	Dimiter	NNP
cord-284409-xiyeceib	176	20	S.	S.	NNP
cord-284409-xiyeceib	176	21	Dimitrov	Dimitrov	NNP
cord-284409-xiyeceib	176	22	,	,	,
cord-284409-xiyeceib	176	23	the	the	DT
cord-284409-xiyeceib	176	24	review	review	NN
cord-284409-xiyeceib	176	25	process	process	NN
cord-284409-xiyeceib	176	26	was	be	VBD
cord-284409-xiyeceib	176	27	handled	handle	VBN
cord-284409-xiyeceib	176	28	objectively	objectively	RB
cord-284409-xiyeceib	176	29	and	and	CC
cord-284409-xiyeceib	176	30	no	no	DT
cord-284409-xiyeceib	176	31	conflict	conflict	NN
cord-284409-xiyeceib	176	32	of	of	IN
cord-284409-xiyeceib	176	33	interest	interest	NN
cord-284409-xiyeceib	176	34	exists	exist	VBZ
cord-284409-xiyeceib	176	35	.	.	.
cord-284409-xiyeceib	177	1	The	the	DT
cord-284409-xiyeceib	177	2	authors	author	NNS
cord-284409-xiyeceib	177	3	declare	declare	VBP
cord-284409-xiyeceib	177	4	that	that	IN
cord-284409-xiyeceib	177	5	the	the	DT
cord-284409-xiyeceib	177	6	research	research	NN
cord-284409-xiyeceib	177	7	was	be	VBD
cord-284409-xiyeceib	177	8	conducted	conduct	VBN
cord-284409-xiyeceib	177	9	in	in	IN
cord-284409-xiyeceib	177	10	the	the	DT
cord-284409-xiyeceib	177	11	absence	absence	NN
cord-284409-xiyeceib	177	12	of	of	IN
cord-284409-xiyeceib	177	13	any	any	DT
cord-284409-xiyeceib	177	14	commercial	commercial	JJ
cord-284409-xiyeceib	177	15	or	or	CC
cord-284409-xiyeceib	177	16	financial	financial	JJ
cord-284409-xiyeceib	177	17	relationships	relationship	NNS
cord-284409-xiyeceib	177	18	that	that	WDT
cord-284409-xiyeceib	177	19	could	could	MD
cord-284409-xiyeceib	177	20	be	be	VB
cord-284409-xiyeceib	177	21	construed	construe	VBN
cord-284409-xiyeceib	177	22	as	as	IN
cord-284409-xiyeceib	177	23	a	a	DT
cord-284409-xiyeceib	177	24	potential	potential	JJ
cord-284409-xiyeceib	177	25	conflict	conflict	NN
cord-284409-xiyeceib	177	26	of	of	IN
cord-284409-xiyeceib	177	27	interest	interest	NN
cord-284409-xiyeceib	177	28	.	.	.
cord-284409-xiyeceib	177	29	 	 	_SP