id	sid	tid	token	lemma	pos
cord-263645-wupre5uj	1	1	key	key	NN
cord-263645-wupre5uj	1	2	:	:	:
cord-263645-wupre5uj	1	3	cord-263645-wupre5uj	cord-263645-wupre5uj	NNP
cord-263645-wupre5uj	1	4	authors	author	NNS
cord-263645-wupre5uj	1	5	:	:	:
cord-263645-wupre5uj	1	6	Morgan	Morgan	NNP
cord-263645-wupre5uj	1	7	,	,	,
cord-263645-wupre5uj	1	8	Brittany	Brittany	NNP
cord-263645-wupre5uj	1	9	S	S	NNP
cord-263645-wupre5uj	1	10	;	;	:
cord-263645-wupre5uj	1	11	Forte	Forte	NNP
cord-263645-wupre5uj	1	12	,	,	,
cord-263645-wupre5uj	1	13	Jordan	Jordan	NNP
cord-263645-wupre5uj	1	14	E	E	NNP
cord-263645-wupre5uj	1	15	;	;	:
cord-263645-wupre5uj	1	16	Hargrove	Hargrove	NNP
cord-263645-wupre5uj	1	17	,	,	,
cord-263645-wupre5uj	1	18	Amanda	Amanda	NNP
cord-263645-wupre5uj	1	19	E	E	NNP
cord-263645-wupre5uj	1	20	title	title	NN
cord-263645-wupre5uj	1	21	:	:	:
cord-263645-wupre5uj	2	1	Insights	insight	NNS
cord-263645-wupre5uj	2	2	into	into	IN
cord-263645-wupre5uj	2	3	the	the	DT
cord-263645-wupre5uj	2	4	development	development	NN
cord-263645-wupre5uj	2	5	of	of	IN
cord-263645-wupre5uj	2	6	chemical	chemical	JJ
cord-263645-wupre5uj	2	7	probes	probe	NNS
cord-263645-wupre5uj	2	8	for	for	IN
cord-263645-wupre5uj	2	9	RNA	RNA	NNP
cord-263645-wupre5uj	2	10	date	date	NN
cord-263645-wupre5uj	2	11	:	:	:
cord-263645-wupre5uj	2	12	2018	2018	CD
cord-263645-wupre5uj	2	13	-	-	HYPH
cord-263645-wupre5uj	2	14	09	09	CD
cord-263645-wupre5uj	2	15	-	-	SYM
cord-263645-wupre5uj	2	16	19	19	CD
cord-263645-wupre5uj	2	17	journal	journal	NN
cord-263645-wupre5uj	2	18	:	:	:
cord-263645-wupre5uj	3	1	Nucleic	nucleic	JJ
cord-263645-wupre5uj	3	2	Acids	acid	NNS
cord-263645-wupre5uj	3	3	Res	res	NN
cord-263645-wupre5uj	3	4	DOI	doi	NN
cord-263645-wupre5uj	3	5	:	:	:
cord-263645-wupre5uj	4	1	10.1093	10.1093	CD
cord-263645-wupre5uj	4	2	/	/	SYM
cord-263645-wupre5uj	4	3	nar	nar	NN
cord-263645-wupre5uj	4	4	/	/	,
cord-263645-wupre5uj	4	5	gky718	gky718	NNP
cord-263645-wupre5uj	4	6	sha	sha	NNP
cord-263645-wupre5uj	4	7	:	:	:
cord-263645-wupre5uj	4	8	cdffb72af0749246fd5f957fda4e793e29911a83	cdffb72af0749246fd5f957fda4e793e29911a83	NNP
cord-263645-wupre5uj	4	9	doc_id	doc_id	NNP
cord-263645-wupre5uj	4	10	:	:	:
cord-263645-wupre5uj	5	1	263645	263645	CD
cord-263645-wupre5uj	5	2	cord_uid	cord_uid	NNS
cord-263645-wupre5uj	5	3	:	:	:
cord-263645-wupre5uj	6	1	wupre5uj	wupre5uj	NNP
cord-263645-wupre5uj	6	2	Over	over	IN
cord-263645-wupre5uj	6	3	the	the	DT
cord-263645-wupre5uj	6	4	past	past	JJ
cord-263645-wupre5uj	6	5	decade	decade	NN
cord-263645-wupre5uj	6	6	,	,	,
cord-263645-wupre5uj	6	7	the	the	DT
cord-263645-wupre5uj	6	8	RNA	RNA	NNP
cord-263645-wupre5uj	6	9	revolution	revolution	NN
cord-263645-wupre5uj	6	10	has	have	VBZ
cord-263645-wupre5uj	6	11	revealed	reveal	VBN
cord-263645-wupre5uj	6	12	thousands	thousand	NNS
cord-263645-wupre5uj	6	13	of	of	IN
cord-263645-wupre5uj	6	14	non	non	JJ
cord-263645-wupre5uj	6	15	-	-	JJ
cord-263645-wupre5uj	6	16	coding	coding	JJ
cord-263645-wupre5uj	6	17	RNAs	rna	NNS
cord-263645-wupre5uj	6	18	that	that	WDT
cord-263645-wupre5uj	6	19	are	be	VBP
cord-263645-wupre5uj	6	20	essential	essential	JJ
cord-263645-wupre5uj	6	21	for	for	IN
cord-263645-wupre5uj	6	22	cellular	cellular	JJ
cord-263645-wupre5uj	6	23	regulation	regulation	NN
cord-263645-wupre5uj	6	24	and	and	CC
cord-263645-wupre5uj	6	25	are	be	VBP
cord-263645-wupre5uj	6	26	misregulated	misregulate	VBN
cord-263645-wupre5uj	6	27	in	in	IN
cord-263645-wupre5uj	6	28	disease	disease	NN
cord-263645-wupre5uj	6	29	.	.	.
cord-263645-wupre5uj	7	1	While	while	IN
cord-263645-wupre5uj	7	2	the	the	DT
cord-263645-wupre5uj	7	3	development	development	NN
cord-263645-wupre5uj	7	4	of	of	IN
cord-263645-wupre5uj	7	5	methods	method	NNS
cord-263645-wupre5uj	7	6	and	and	CC
cord-263645-wupre5uj	7	7	tools	tool	NNS
cord-263645-wupre5uj	7	8	to	to	TO
cord-263645-wupre5uj	7	9	study	study	VB
cord-263645-wupre5uj	7	10	these	these	DT
cord-263645-wupre5uj	7	11	RNAs	rna	NNS
cord-263645-wupre5uj	7	12	has	have	VBZ
cord-263645-wupre5uj	7	13	been	be	VBN
cord-263645-wupre5uj	7	14	challenging	challenge	VBG
cord-263645-wupre5uj	7	15	,	,	,
cord-263645-wupre5uj	7	16	the	the	DT
cord-263645-wupre5uj	7	17	power	power	NN
cord-263645-wupre5uj	7	18	and	and	CC
cord-263645-wupre5uj	7	19	promise	promise	NN
cord-263645-wupre5uj	7	20	of	of	IN
cord-263645-wupre5uj	7	21	small	small	JJ
cord-263645-wupre5uj	7	22	molecule	molecule	NN
cord-263645-wupre5uj	7	23	chemical	chemical	NN
cord-263645-wupre5uj	7	24	probes	probe	NNS
cord-263645-wupre5uj	7	25	is	be	VBZ
cord-263645-wupre5uj	7	26	increasingly	increasingly	RB
cord-263645-wupre5uj	7	27	recognized	recognize	VBN
cord-263645-wupre5uj	7	28	.	.	.
cord-263645-wupre5uj	8	1	To	to	TO
cord-263645-wupre5uj	8	2	harness	harness	VB
cord-263645-wupre5uj	8	3	existing	exist	VBG
cord-263645-wupre5uj	8	4	knowledge	knowledge	NN
cord-263645-wupre5uj	8	5	,	,	,
cord-263645-wupre5uj	8	6	we	-PRON-	PRP
cord-263645-wupre5uj	8	7	compiled	compile	VBD
cord-263645-wupre5uj	8	8	a	a	DT
cord-263645-wupre5uj	8	9	list	list	NN
cord-263645-wupre5uj	8	10	of	of	IN
cord-263645-wupre5uj	8	11	116	116	CD
cord-263645-wupre5uj	8	12	ligands	ligand	NNS
cord-263645-wupre5uj	8	13	with	with	IN
cord-263645-wupre5uj	8	14	reported	report	VBN
cord-263645-wupre5uj	8	15	activity	activity	NN
cord-263645-wupre5uj	8	16	against	against	IN
cord-263645-wupre5uj	8	17	RNA	RNA	NNP
cord-263645-wupre5uj	8	18	targets	target	NNS
cord-263645-wupre5uj	8	19	in	in	IN
cord-263645-wupre5uj	8	20	biological	biological	JJ
cord-263645-wupre5uj	8	21	systems	system	NNS
cord-263645-wupre5uj	9	1	(	(	-LRB-
cord-263645-wupre5uj	9	2	R	r	NN
cord-263645-wupre5uj	9	3	-	-	HYPH
cord-263645-wupre5uj	9	4	BIND	BIND	NNP
cord-263645-wupre5uj	9	5	)	)	-RRB-
cord-263645-wupre5uj	9	6	.	.	.
cord-263645-wupre5uj	10	1	In	in	IN
cord-263645-wupre5uj	10	2	this	this	DT
cord-263645-wupre5uj	10	3	survey	survey	NN
cord-263645-wupre5uj	10	4	,	,	,
cord-263645-wupre5uj	10	5	we	-PRON-	PRP
cord-263645-wupre5uj	10	6	examine	examine	VBP
cord-263645-wupre5uj	10	7	the	the	DT
cord-263645-wupre5uj	10	8	RNA	RNA	NNP
cord-263645-wupre5uj	10	9	targets	target	NNS
cord-263645-wupre5uj	10	10	,	,	,
cord-263645-wupre5uj	10	11	design	design	NN
cord-263645-wupre5uj	10	12	and	and	CC
cord-263645-wupre5uj	10	13	discovery	discovery	NN
cord-263645-wupre5uj	10	14	strategies	strategy	NNS
cord-263645-wupre5uj	10	15	,	,	,
cord-263645-wupre5uj	10	16	and	and	CC
cord-263645-wupre5uj	10	17	chemical	chemical	NN
cord-263645-wupre5uj	10	18	probe	probe	NN
cord-263645-wupre5uj	10	19	characterization	characterization	NN
cord-263645-wupre5uj	10	20	techniques	technique	NNS
cord-263645-wupre5uj	10	21	of	of	IN
cord-263645-wupre5uj	10	22	these	these	DT
cord-263645-wupre5uj	10	23	ligands	ligand	NNS
cord-263645-wupre5uj	10	24	.	.	.
cord-263645-wupre5uj	11	1	We	-PRON-	PRP
cord-263645-wupre5uj	11	2	discuss	discuss	VBP
cord-263645-wupre5uj	11	3	the	the	DT
cord-263645-wupre5uj	11	4	applicability	applicability	NN
cord-263645-wupre5uj	11	5	of	of	IN
cord-263645-wupre5uj	11	6	current	current	JJ
cord-263645-wupre5uj	11	7	tools	tool	NNS
cord-263645-wupre5uj	11	8	to	to	TO
cord-263645-wupre5uj	11	9	identify	identify	VB
cord-263645-wupre5uj	11	10	and	and	CC
cord-263645-wupre5uj	11	11	evaluate	evaluate	VB
cord-263645-wupre5uj	11	12	RNA	RNA	NNP
cord-263645-wupre5uj	11	13	-	-	HYPH
cord-263645-wupre5uj	11	14	targeted	target	VBN
cord-263645-wupre5uj	11	15	chemical	chemical	NN
cord-263645-wupre5uj	11	16	probes	probe	NNS
cord-263645-wupre5uj	11	17	,	,	,
cord-263645-wupre5uj	11	18	suggest	suggest	VBP
cord-263645-wupre5uj	11	19	criteria	criterion	NNS
cord-263645-wupre5uj	11	20	to	to	TO
cord-263645-wupre5uj	11	21	assess	assess	VB
cord-263645-wupre5uj	11	22	the	the	DT
cord-263645-wupre5uj	11	23	quality	quality	NN
cord-263645-wupre5uj	11	24	of	of	IN
cord-263645-wupre5uj	11	25	RNA	RNA	NNP
cord-263645-wupre5uj	11	26	chemical	chemical	NN
cord-263645-wupre5uj	11	27	probes	probe	NNS
cord-263645-wupre5uj	11	28	and	and	CC
cord-263645-wupre5uj	11	29	targets	target	NNS
cord-263645-wupre5uj	11	30	,	,	,
cord-263645-wupre5uj	11	31	and	and	CC
cord-263645-wupre5uj	11	32	propose	propose	VB
cord-263645-wupre5uj	11	33	areas	area	NNS
cord-263645-wupre5uj	11	34	where	where	WRB
cord-263645-wupre5uj	11	35	new	new	JJ
cord-263645-wupre5uj	11	36	tools	tool	NNS
cord-263645-wupre5uj	11	37	are	be	VBP
cord-263645-wupre5uj	11	38	particularly	particularly	RB
cord-263645-wupre5uj	11	39	needed	need	VBN
cord-263645-wupre5uj	11	40	.	.	.
cord-263645-wupre5uj	12	1	We	-PRON-	PRP
cord-263645-wupre5uj	12	2	anticipate	anticipate	VBP
cord-263645-wupre5uj	12	3	that	that	IN
cord-263645-wupre5uj	12	4	this	this	DT
cord-263645-wupre5uj	12	5	knowledge	knowledge	NN
cord-263645-wupre5uj	12	6	will	will	MD
cord-263645-wupre5uj	12	7	expedite	expedite	VB
cord-263645-wupre5uj	12	8	the	the	DT
cord-263645-wupre5uj	12	9	discovery	discovery	NN
cord-263645-wupre5uj	12	10	of	of	IN
cord-263645-wupre5uj	12	11	RNA	RNA	NNP
cord-263645-wupre5uj	12	12	-	-	HYPH
cord-263645-wupre5uj	12	13	targeted	target	VBN
cord-263645-wupre5uj	12	14	ligands	ligand	NNS
cord-263645-wupre5uj	12	15	and	and	CC
cord-263645-wupre5uj	12	16	the	the	DT
cord-263645-wupre5uj	12	17	next	next	JJ
cord-263645-wupre5uj	12	18	phase	phase	NN
cord-263645-wupre5uj	12	19	of	of	IN
cord-263645-wupre5uj	12	20	the	the	DT
cord-263645-wupre5uj	12	21	RNA	RNA	NNP
cord-263645-wupre5uj	12	22	revolution	revolution	NN
cord-263645-wupre5uj	12	23	.	.	.
cord-263645-wupre5uj	13	1	The	the	DT
cord-263645-wupre5uj	13	2	field	field	NN
cord-263645-wupre5uj	13	3	of	of	IN
cord-263645-wupre5uj	13	4	RNA	RNA	NNP
cord-263645-wupre5uj	13	5	biology	biology	NN
cord-263645-wupre5uj	13	6	has	have	VBZ
cord-263645-wupre5uj	13	7	exploded	explode	VBN
cord-263645-wupre5uj	13	8	in	in	IN
cord-263645-wupre5uj	13	9	recent	recent	JJ
cord-263645-wupre5uj	13	10	years	year	NNS
cord-263645-wupre5uj	13	11	with	with	IN
cord-263645-wupre5uj	13	12	the	the	DT
cord-263645-wupre5uj	13	13	discovery	discovery	NN
cord-263645-wupre5uj	13	14	of	of	IN
cord-263645-wupre5uj	13	15	non	non	JJ
cord-263645-wupre5uj	13	16	-	-	JJ
cord-263645-wupre5uj	13	17	coding	coding	JJ
cord-263645-wupre5uj	13	18	RNAs	rna	NNS
cord-263645-wupre5uj	13	19	(	(	-LRB-
cord-263645-wupre5uj	13	20	ncRNAs	ncRNAs	NNP
cord-263645-wupre5uj	13	21	)	)	-RRB-
cord-263645-wupre5uj	13	22	that	that	WDT
cord-263645-wupre5uj	13	23	regulate	regulate	VBP
cord-263645-wupre5uj	13	24	essential	essential	JJ
cord-263645-wupre5uj	13	25	processes	process	NNS
cord-263645-wupre5uj	13	26	in	in	IN
cord-263645-wupre5uj	13	27	all	all	DT
cord-263645-wupre5uj	13	28	living	live	VBG
cord-263645-wupre5uj	13	29	organisms	organism	NNS
cord-263645-wupre5uj	13	30	(	(	-LRB-
cord-263645-wupre5uj	13	31	1	1	CD
cord-263645-wupre5uj	13	32	)	)	-RRB-
cord-263645-wupre5uj	13	33	.	.	.
cord-263645-wupre5uj	14	1	These	these	DT
cord-263645-wupre5uj	14	2	processes	process	NNS
cord-263645-wupre5uj	14	3	include	include	VBP
cord-263645-wupre5uj	14	4	transcription	transcription	NN
cord-263645-wupre5uj	14	5	,	,	,
cord-263645-wupre5uj	14	6	translation	translation	NN
cord-263645-wupre5uj	14	7	,	,	,
cord-263645-wupre5uj	14	8	and	and	CC
cord-263645-wupre5uj	14	9	evasion	evasion	NN
cord-263645-wupre5uj	14	10	in	in	IN
cord-263645-wupre5uj	14	11	bacteria	bacteria	NNS
cord-263645-wupre5uj	14	12	and	and	CC
cord-263645-wupre5uj	14	13	archaea	archaea	NNS
cord-263645-wupre5uj	14	14	(	(	-LRB-
cord-263645-wupre5uj	14	15	1	1	CD
cord-263645-wupre5uj	14	16	,	,	,
cord-263645-wupre5uj	14	17	2	2	CD
cord-263645-wupre5uj	14	18	)	)	-RRB-
cord-263645-wupre5uj	14	19	as	as	RB
cord-263645-wupre5uj	14	20	well	well	RB
cord-263645-wupre5uj	14	21	as	as	IN
cord-263645-wupre5uj	14	22	replication	replication	NN
cord-263645-wupre5uj	14	23	,	,	,
cord-263645-wupre5uj	14	24	persistence	persistence	NN
cord-263645-wupre5uj	14	25	,	,	,
cord-263645-wupre5uj	14	26	and	and	CC
cord-263645-wupre5uj	14	27	cellular	cellular	JJ
cord-263645-wupre5uj	14	28	transformation	transformation	NN
cord-263645-wupre5uj	14	29	in	in	IN
cord-263645-wupre5uj	14	30	viruses	virus	NNS
cord-263645-wupre5uj	14	31	(	(	-LRB-
cord-263645-wupre5uj	14	32	3	3	CD
cord-263645-wupre5uj	14	33	)	)	-RRB-
cord-263645-wupre5uj	14	34	.	.	.
cord-263645-wupre5uj	15	1	Within	within	IN
cord-263645-wupre5uj	15	2	the	the	DT
cord-263645-wupre5uj	15	3	human	human	JJ
cord-263645-wupre5uj	15	4	genome	genome	NN
cord-263645-wupre5uj	15	5	,	,	,
cord-263645-wupre5uj	15	6	protein	protein	NN
cord-263645-wupre5uj	15	7	-	-	HYPH
cord-263645-wupre5uj	15	8	coding	code	VBG
cord-263645-wupre5uj	15	9	genes	gene	NNS
cord-263645-wupre5uj	15	10	are	be	VBP
cord-263645-wupre5uj	15	11	vastly	vastly	RB
cord-263645-wupre5uj	15	12	outnumbered	outnumber	VBN
cord-263645-wupre5uj	15	13	by	by	IN
cord-263645-wupre5uj	15	14	regulatory	regulatory	JJ
cord-263645-wupre5uj	15	15	ncRNAs	ncrna	NNS
cord-263645-wupre5uj	15	16	that	that	WDT
cord-263645-wupre5uj	15	17	can	can	MD
cord-263645-wupre5uj	15	18	influence	influence	VB
cord-263645-wupre5uj	15	19	a	a	DT
cord-263645-wupre5uj	15	20	wide	wide	JJ
cord-263645-wupre5uj	15	21	range	range	NN
cord-263645-wupre5uj	15	22	of	of	IN
cord-263645-wupre5uj	15	23	cellular	cellular	JJ
cord-263645-wupre5uj	15	24	functions	function	NNS
cord-263645-wupre5uj	15	25	(	(	-LRB-
cord-263645-wupre5uj	15	26	2	2	CD
cord-263645-wupre5uj	15	27	,	,	,
cord-263645-wupre5uj	15	28	4	4	CD
cord-263645-wupre5uj	15	29	)	)	-RRB-
cord-263645-wupre5uj	15	30	.	.	.
cord-263645-wupre5uj	16	1	Many	many	JJ
cord-263645-wupre5uj	16	2	of	of	IN
cord-263645-wupre5uj	16	3	these	these	DT
cord-263645-wupre5uj	16	4	ncRNAs	ncrna	NNS
cord-263645-wupre5uj	16	5	are	be	VBP
cord-263645-wupre5uj	16	6	dysregulated	dysregulate	VBN
cord-263645-wupre5uj	16	7	in	in	IN
cord-263645-wupre5uj	16	8	and	and	CC
cord-263645-wupre5uj	16	9	implicated	implicate	VBN
cord-263645-wupre5uj	16	10	as	as	IN
cord-263645-wupre5uj	16	11	drivers	driver	NNS
cord-263645-wupre5uj	16	12	of	of	IN
cord-263645-wupre5uj	16	13	various	various	JJ
cord-263645-wupre5uj	16	14	human	human	JJ
cord-263645-wupre5uj	16	15	diseases	disease	NNS
cord-263645-wupre5uj	16	16	,	,	,
cord-263645-wupre5uj	16	17	including	include	VBG
cord-263645-wupre5uj	16	18	metastatic	metastatic	JJ
cord-263645-wupre5uj	16	19	cancers	cancer	NNS
cord-263645-wupre5uj	16	20	and	and	CC
cord-263645-wupre5uj	16	21	neurologi	neurologi	NNP
cord-263645-wupre5uj	16	22	-	-	HYPH
cord-263645-wupre5uj	16	23	cal	cal	NNP
cord-263645-wupre5uj	16	24	and	and	CC
cord-263645-wupre5uj	16	25	neuromuscular	neuromuscular	JJ
cord-263645-wupre5uj	16	26	disorders	disorder	NNS
cord-263645-wupre5uj	16	27	(	(	-LRB-
cord-263645-wupre5uj	16	28	2	2	CD
cord-263645-wupre5uj	16	29	,	,	,
cord-263645-wupre5uj	16	30	5	5	CD
cord-263645-wupre5uj	16	31	,	,	,
cord-263645-wupre5uj	16	32	6	6	CD
cord-263645-wupre5uj	16	33	)	)	-RRB-
cord-263645-wupre5uj	16	34	.	.	.
cord-263645-wupre5uj	17	1	This	this	DT
cord-263645-wupre5uj	17	2	'	'	``
cord-263645-wupre5uj	17	3	RNA	RNA	NNP
cord-263645-wupre5uj	17	4	revolution	revolution	NN
cord-263645-wupre5uj	17	5	'	'	''
cord-263645-wupre5uj	17	6	is	be	VBZ
cord-263645-wupre5uj	17	7	radically	radically	RB
cord-263645-wupre5uj	17	8	changing	change	VBG
cord-263645-wupre5uj	17	9	our	-PRON-	PRP$
cord-263645-wupre5uj	17	10	understanding	understanding	NN
cord-263645-wupre5uj	17	11	of	of	IN
cord-263645-wupre5uj	17	12	the	the	DT
cord-263645-wupre5uj	17	13	role	role	NN
cord-263645-wupre5uj	17	14	RNA	RNA	NNP
cord-263645-wupre5uj	17	15	plays	play	VBZ
cord-263645-wupre5uj	17	16	in	in	IN
cord-263645-wupre5uj	17	17	fundamental	fundamental	JJ
cord-263645-wupre5uj	17	18	biology	biology	NN
cord-263645-wupre5uj	17	19	and	and	CC
cord-263645-wupre5uj	17	20	is	be	VBZ
cord-263645-wupre5uj	17	21	rapidly	rapidly	RB
cord-263645-wupre5uj	17	22	driving	drive	VBG
cord-263645-wupre5uj	17	23	scientific	scientific	JJ
cord-263645-wupre5uj	17	24	innovation	innovation	NN
cord-263645-wupre5uj	17	25	.	.	.
cord-263645-wupre5uj	18	1	Methods	method	NNS
cord-263645-wupre5uj	18	2	and	and	CC
cord-263645-wupre5uj	18	3	tools	tool	NNS
cord-263645-wupre5uj	18	4	to	to	TO
cord-263645-wupre5uj	18	5	structurally	structurally	RB
cord-263645-wupre5uj	18	6	and	and	CC
cord-263645-wupre5uj	18	7	functionally	functionally	RB
cord-263645-wupre5uj	18	8	characterize	characterize	VB
cord-263645-wupre5uj	18	9	RNAs	rna	NNS
cord-263645-wupre5uj	18	10	at	at	IN
cord-263645-wupre5uj	18	11	the	the	DT
cord-263645-wupre5uj	18	12	molecular	molecular	JJ
cord-263645-wupre5uj	18	13	level	level	NN
cord-263645-wupre5uj	18	14	,	,	,
cord-263645-wupre5uj	18	15	however	however	RB
cord-263645-wupre5uj	18	16	,	,	,
cord-263645-wupre5uj	18	17	are	be	VBP
cord-263645-wupre5uj	18	18	more	more	RBR
cord-263645-wupre5uj	18	19	difficult	difficult	JJ
cord-263645-wupre5uj	18	20	and/or	and/or	CC
cord-263645-wupre5uj	18	21	lacking	lack	VBG
cord-263645-wupre5uj	18	22	as	as	IN
cord-263645-wupre5uj	18	23	compared	compare	VBN
cord-263645-wupre5uj	18	24	to	to	IN
cord-263645-wupre5uj	18	25	those	those	DT
cord-263645-wupre5uj	18	26	for	for	IN
cord-263645-wupre5uj	18	27	proteins	protein	NNS
cord-263645-wupre5uj	18	28	(	(	-LRB-
cord-263645-wupre5uj	18	29	7	7	CD
cord-263645-wupre5uj	18	30	)	)	-RRB-
cord-263645-wupre5uj	18	31	(	(	-LRB-
cord-263645-wupre5uj	18	32	8)	8)	NNP
cord-263645-wupre5uj	18	33	(	(	-LRB-
cord-263645-wupre5uj	18	34	9	9	CD
cord-263645-wupre5uj	18	35	)	)	-RRB-
cord-263645-wupre5uj	18	36	(	(	-LRB-
cord-263645-wupre5uj	18	37	10	10	CD
cord-263645-wupre5uj	18	38	)	)	-RRB-
cord-263645-wupre5uj	18	39	.	.	.
cord-263645-wupre5uj	19	1	One	one	CD
cord-263645-wupre5uj	19	2	important	important	JJ
cord-263645-wupre5uj	19	3	example	example	NN
cord-263645-wupre5uj	19	4	is	be	VBZ
cord-263645-wupre5uj	19	5	the	the	DT
cord-263645-wupre5uj	19	6	development	development	NN
cord-263645-wupre5uj	19	7	of	of	IN
cord-263645-wupre5uj	19	8	chemical	chemical	JJ
cord-263645-wupre5uj	19	9	probes	probe	NNS
cord-263645-wupre5uj	19	10	,	,	,
cord-263645-wupre5uj	19	11	which	which	WDT
cord-263645-wupre5uj	19	12	has	have	VBZ
cord-263645-wupre5uj	19	13	greatly	greatly	RB
cord-263645-wupre5uj	19	14	progressed	progress	VBN
cord-263645-wupre5uj	19	15	the	the	DT
cord-263645-wupre5uj	19	16	study	study	NN
cord-263645-wupre5uj	19	17	of	of	IN
cord-263645-wupre5uj	19	18	proteins	protein	NNS
cord-263645-wupre5uj	19	19	and	and	CC
cord-263645-wupre5uj	19	20	related	related	JJ
cord-263645-wupre5uj	19	21	diseases	disease	NNS
cord-263645-wupre5uj	19	22	(	(	-LRB-
cord-263645-wupre5uj	19	23	11	11	CD
cord-263645-wupre5uj	19	24	,	,	,
cord-263645-wupre5uj	19	25	12	12	CD
cord-263645-wupre5uj	19	26	)	)	-RRB-
cord-263645-wupre5uj	19	27	but	but	CC
cord-263645-wupre5uj	19	28	has	have	VBZ
cord-263645-wupre5uj	19	29	been	be	VBN
cord-263645-wupre5uj	19	30	challenging	challenge	VBG
cord-263645-wupre5uj	19	31	for	for	IN
cord-263645-wupre5uj	19	32	non	non	JJ
cord-263645-wupre5uj	19	33	-	-	JJ
cord-263645-wupre5uj	19	34	ribosomal	ribosomal	JJ
cord-263645-wupre5uj	19	35	RNAs	rna	NNS
cord-263645-wupre5uj	19	36	.	.	.
cord-263645-wupre5uj	20	1	This	this	DT
cord-263645-wupre5uj	20	2	powerful	powerful	JJ
cord-263645-wupre5uj	20	3	chemical	chemical	NN
cord-263645-wupre5uj	20	4	tool	tool	NN
cord-263645-wupre5uj	20	5	requires	require	VBZ
cord-263645-wupre5uj	20	6	small	small	JJ
cord-263645-wupre5uj	20	7	molecules	molecule	NNS
cord-263645-wupre5uj	20	8	with	with	IN
cord-263645-wupre5uj	20	9	well	well	RB
cord-263645-wupre5uj	20	10	-	-	HYPH
cord-263645-wupre5uj	20	11	defined	define	VBN
cord-263645-wupre5uj	20	12	biological	biological	JJ
cord-263645-wupre5uj	20	13	activity	activity	NN
cord-263645-wupre5uj	20	14	,	,	,
cord-263645-wupre5uj	20	15	cell	cell	NN
cord-263645-wupre5uj	20	16	permeability	permeability	NN
cord-263645-wupre5uj	20	17	,	,	,
cord-263645-wupre5uj	20	18	and	and	CC
cord-263645-wupre5uj	20	19	selectivity	selectivity	NN
cord-263645-wupre5uj	20	20	to	to	TO
cord-263645-wupre5uj	20	21	accurately	accurately	RB
cord-263645-wupre5uj	20	22	and	and	CC
cord-263645-wupre5uj	20	23	reliably	reliably	RB
cord-263645-wupre5uj	20	24	probe	probe	VB
cord-263645-wupre5uj	20	25	specific	specific	JJ
cord-263645-wupre5uj	20	26	mechanistic	mechanistic	JJ
cord-263645-wupre5uj	20	27	and	and	CC
cord-263645-wupre5uj	20	28	phenotypic	phenotypic	JJ
cord-263645-wupre5uj	20	29	questions	question	NNS
cord-263645-wupre5uj	20	30	(	(	-LRB-
cord-263645-wupre5uj	20	31	11	11	CD
cord-263645-wupre5uj	20	32	,	,	,
cord-263645-wupre5uj	20	33	12	12	CD
cord-263645-wupre5uj	20	34	)	)	-RRB-
cord-263645-wupre5uj	20	35	.	.	.
cord-263645-wupre5uj	21	1	Given	give	VBN
cord-263645-wupre5uj	21	2	the	the	DT
cord-263645-wupre5uj	21	3	potential	potential	JJ
cord-263645-wupre5uj	21	4	advantages	advantage	NNS
cord-263645-wupre5uj	21	5	of	of	IN
cord-263645-wupre5uj	21	6	small	small	JJ
cord-263645-wupre5uj	21	7	molecule	molecule	NN
cord-263645-wupre5uj	21	8	chemical	chemical	NN
cord-263645-wupre5uj	21	9	probes	probe	NNS
cord-263645-wupre5uj	21	10	over	over	IN
cord-263645-wupre5uj	21	11	biological	biological	JJ
cord-263645-wupre5uj	21	12	approaches	approach	NNS
cord-263645-wupre5uj	21	13	(	(	-LRB-
cord-263645-wupre5uj	21	14	e.g.	e.g.	IN
cord-263645-wupre5uj	21	15	siRNAs	siRNAs	NNP
cord-263645-wupre5uj	21	16	,	,	,
cord-263645-wupre5uj	21	17	ASOs	ASOs	NNP
cord-263645-wupre5uj	21	18	and	and	CC
cord-263645-wupre5uj	21	19	CRISPR	CRISPR	NNP
cord-263645-wupre5uj	21	20	-	-	HYPH
cord-263645-wupre5uj	21	21	Cas	Cas	NNP
cord-263645-wupre5uj	21	22	)	)	-RRB-
cord-263645-wupre5uj	21	23	(	(	-LRB-
cord-263645-wupre5uj	21	24	13	13	CD
cord-263645-wupre5uj	21	25	,	,	,
cord-263645-wupre5uj	21	26	14	14	CD
cord-263645-wupre5uj	21	27	)	)	-RRB-
cord-263645-wupre5uj	21	28	and	and	CC
cord-263645-wupre5uj	21	29	the	the	DT
cord-263645-wupre5uj	21	30	power	power	NN
cord-263645-wupre5uj	21	31	of	of	IN
cord-263645-wupre5uj	21	32	using	use	VBG
cord-263645-wupre5uj	21	33	both	both	DT
cord-263645-wupre5uj	21	34	approaches	approach	NNS
cord-263645-wupre5uj	21	35	in	in	IN
cord-263645-wupre5uj	21	36	tandem	tandem	NN
cord-263645-wupre5uj	21	37	(	(	-LRB-
cord-263645-wupre5uj	21	38	12	12	CD
cord-263645-wupre5uj	21	39	)	)	-RRB-
cord-263645-wupre5uj	21	40	,	,	,
cord-263645-wupre5uj	21	41	the	the	DT
cord-263645-wupre5uj	21	42	development	development	NN
cord-263645-wupre5uj	21	43	of	of	IN
cord-263645-wupre5uj	21	44	RNAtargeted	rnatargeted	JJ
cord-263645-wupre5uj	21	45	chemical	chemical	NN
cord-263645-wupre5uj	21	46	probes	probe	NNS
cord-263645-wupre5uj	21	47	has	have	VBZ
cord-263645-wupre5uj	21	48	the	the	DT
cord-263645-wupre5uj	21	49	potential	potential	NN
cord-263645-wupre5uj	21	50	to	to	TO
cord-263645-wupre5uj	21	51	greatly	greatly	RB
cord-263645-wupre5uj	21	52	benefit	benefit	VB
cord-263645-wupre5uj	21	53	both	both	DT
cord-263645-wupre5uj	21	54	chemists	chemist	NNS
cord-263645-wupre5uj	21	55	and	and	CC
cord-263645-wupre5uj	21	56	biologists	biologist	NNS
cord-263645-wupre5uj	21	57	interested	interested	JJ
cord-263645-wupre5uj	21	58	in	in	IN
cord-263645-wupre5uj	21	59	RNA	RNA	NNP
cord-263645-wupre5uj	21	60	.	.	.
cord-263645-wupre5uj	22	1	While	while	IN
cord-263645-wupre5uj	22	2	ligands	ligand	NNS
cord-263645-wupre5uj	22	3	that	that	WDT
cord-263645-wupre5uj	22	4	bind	bind	VBP
cord-263645-wupre5uj	22	5	non	non	JJ
cord-263645-wupre5uj	22	6	-	-	JJ
cord-263645-wupre5uj	22	7	ribosomal	ribosomal	JJ
cord-263645-wupre5uj	22	8	RNA	RNA	NNP
cord-263645-wupre5uj	22	9	in	in	IN
cord-263645-wupre5uj	22	10	vitro	vitro	FW
cord-263645-wupre5uj	22	11	have	have	VBP
cord-263645-wupre5uj	22	12	been	be	VBN
cord-263645-wupre5uj	22	13	reported	report	VBN
cord-263645-wupre5uj	22	14	for	for	IN
cord-263645-wupre5uj	22	15	decades	decade	NNS
cord-263645-wupre5uj	22	16	,	,	,
cord-263645-wupre5uj	22	17	the	the	DT
cord-263645-wupre5uj	22	18	development	development	NN
cord-263645-wupre5uj	22	19	of	of	IN
cord-263645-wupre5uj	22	20	chemical	chemical	JJ
cord-263645-wupre5uj	22	21	probes	probe	NNS
cord-263645-wupre5uj	22	22	with	with	IN
cord-263645-wupre5uj	22	23	evidence	evidence	NN
cord-263645-wupre5uj	22	24	of	of	IN
cord-263645-wupre5uj	22	25	specific	specific	JJ
cord-263645-wupre5uj	22	26	small	small	JJ
cord-263645-wupre5uj	22	27	molecule	molecule	NN
cord-263645-wupre5uj	22	28	:	:	:
cord-263645-wupre5uj	22	29	RNA	RNA	NNP
cord-263645-wupre5uj	22	30	engagement	engagement	NN
cord-263645-wupre5uj	22	31	in	in	IN
cord-263645-wupre5uj	22	32	cell	cell	NN
cord-263645-wupre5uj	22	33	or	or	CC
cord-263645-wupre5uj	22	34	animal	animal	NN
cord-263645-wupre5uj	22	35	models	model	NNS
cord-263645-wupre5uj	22	36	has	have	VBZ
cord-263645-wupre5uj	22	37	dramatically	dramatically	RB
cord-263645-wupre5uj	22	38	increased	increase	VBN
cord-263645-wupre5uj	22	39	in	in	IN
cord-263645-wupre5uj	22	40	the	the	DT
cord-263645-wupre5uj	22	41	last	last	JJ
cord-263645-wupre5uj	22	42	four	four	CD
cord-263645-wupre5uj	22	43	years	year	NNS
cord-263645-wupre5uj	22	44	.	.	.
cord-263645-wupre5uj	23	1	Recent	recent	JJ
cord-263645-wupre5uj	23	2	studies	study	NNS
cord-263645-wupre5uj	23	3	report	report	VBP
cord-263645-wupre5uj	23	4	several	several	JJ
cord-263645-wupre5uj	23	5	drug	drug	NN
cord-263645-wupre5uj	23	6	-	-	HYPH
cord-263645-wupre5uj	23	7	like	like	JJ
cord-263645-wupre5uj	23	8	small	small	JJ
cord-263645-wupre5uj	23	9	molecules	molecule	NNS
cord-263645-wupre5uj	23	10	that	that	WDT
cord-263645-wupre5uj	23	11	target	target	VBP
cord-263645-wupre5uj	23	12	a	a	DT
cord-263645-wupre5uj	23	13	range	range	NN
cord-263645-wupre5uj	23	14	of	of	IN
cord-263645-wupre5uj	23	15	RNAs	rna	NNS
cord-263645-wupre5uj	23	16	in	in	IN
cord-263645-wupre5uj	23	17	animal	animal	NN
cord-263645-wupre5uj	23	18	models	model	NNS
cord-263645-wupre5uj	23	19	,	,	,
cord-263645-wupre5uj	23	20	including	include	VBG
cord-263645-wupre5uj	23	21	riboswitches	riboswitche	NNS
cord-263645-wupre5uj	23	22	(	(	-LRB-
cord-263645-wupre5uj	23	23	15	15	CD
cord-263645-wupre5uj	23	24	)	)	-RRB-
cord-263645-wupre5uj	23	25	,	,	,
cord-263645-wupre5uj	23	26	miRNAs	miRNAs	NNP
cord-263645-wupre5uj	23	27	,	,	,
cord-263645-wupre5uj	23	28	(	(	-LRB-
cord-263645-wupre5uj	23	29	16	16	CD
cord-263645-wupre5uj	23	30	,	,	,
cord-263645-wupre5uj	23	31	17	17	CD
cord-263645-wupre5uj	23	32	)	)	-RRB-
cord-263645-wupre5uj	23	33	splice	splice	NN
cord-263645-wupre5uj	23	34	sites	site	NNS
cord-263645-wupre5uj	23	35	(	(	-LRB-
cord-263645-wupre5uj	23	36	18	18	CD
cord-263645-wupre5uj	23	37	)	)	-RRB-
cord-263645-wupre5uj	23	38	,	,	,
cord-263645-wupre5uj	23	39	and	and	CC
cord-263645-wupre5uj	23	40	mature	mature	VB
cord-263645-wupre5uj	23	41	mRNAs	mRNAs	''
cord-263645-wupre5uj	23	42	(	(	-LRB-
cord-263645-wupre5uj	23	43	19	19	CD
cord-263645-wupre5uj	23	44	)	)	-RRB-
cord-263645-wupre5uj	23	45	,	,	,
cord-263645-wupre5uj	23	46	at	at	RB
cord-263645-wupre5uj	23	47	least	least	RBS
cord-263645-wupre5uj	23	48	one	one	CD
cord-263645-wupre5uj	23	49	of	of	IN
cord-263645-wupre5uj	23	50	which	which	WDT
cord-263645-wupre5uj	23	51	is	be	VBZ
cord-263645-wupre5uj	23	52	currently	currently	RB
cord-263645-wupre5uj	23	53	in	in	IN
cord-263645-wupre5uj	23	54	clinical	clinical	JJ
cord-263645-wupre5uj	23	55	trials	trial	NNS
cord-263645-wupre5uj	23	56	(	(	-LRB-
cord-263645-wupre5uj	23	57	NCT02268552	NCT02268552	NNP
cord-263645-wupre5uj	23	58	)	)	-RRB-
cord-263645-wupre5uj	23	59	.	.	.
cord-263645-wupre5uj	24	1	Multivalent	Multivalent	NNP
cord-263645-wupre5uj	24	2	ligands	ligand	NNS
cord-263645-wupre5uj	24	3	have	have	VBP
cord-263645-wupre5uj	24	4	been	be	VBN
cord-263645-wupre5uj	24	5	reported	report	VBN
cord-263645-wupre5uj	24	6	that	that	DT
cord-263645-wupre5uj	24	7	target	target	NN
cord-263645-wupre5uj	24	8	r(CUG	r(cug	CD
cord-263645-wupre5uj	24	9	)	)	-RRB-
cord-263645-wupre5uj	24	10	exp	exp	NN
cord-263645-wupre5uj	24	11	repeats	repeat	NNS
cord-263645-wupre5uj	24	12	of	of	IN
cord-263645-wupre5uj	24	13	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	24	14	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	24	15	Type	Type	NNP
cord-263645-wupre5uj	24	16	1	1	CD
cord-263645-wupre5uj	24	17	(	(	-LRB-
cord-263645-wupre5uj	24	18	DM1	dm1	NN
cord-263645-wupre5uj	24	19	)	)	-RRB-
cord-263645-wupre5uj	24	20	in	in	IN
cord-263645-wupre5uj	24	21	D.	D.	NNP
cord-263645-wupre5uj	24	22	melanogaster	melanogaster	NNP
cord-263645-wupre5uj	24	23	(	(	-LRB-
cord-263645-wupre5uj	24	24	20	20	CD
cord-263645-wupre5uj	24	25	)	)	-RRB-
cord-263645-wupre5uj	24	26	and	and	CC
cord-263645-wupre5uj	24	27	mouse	mouse	NN
cord-263645-wupre5uj	24	28	models	model	NNS
cord-263645-wupre5uj	24	29	(	(	-LRB-
cord-263645-wupre5uj	24	30	21	21	CD
cord-263645-wupre5uj	24	31	)	)	-RRB-
cord-263645-wupre5uj	24	32	.	.	.
cord-263645-wupre5uj	25	1	These	these	DT
cord-263645-wupre5uj	25	2	recent	recent	JJ
cord-263645-wupre5uj	25	3	successes	success	NNS
cord-263645-wupre5uj	25	4	confirm	confirm	VBP
cord-263645-wupre5uj	25	5	that	that	IN
cord-263645-wupre5uj	25	6	selective	selective	JJ
cord-263645-wupre5uj	25	7	RNA	RNA	NNP
cord-263645-wupre5uj	25	8	targeting	targeting	NN
cord-263645-wupre5uj	25	9	is	be	VBZ
cord-263645-wupre5uj	25	10	achievable	achievable	JJ
cord-263645-wupre5uj	25	11	in	in	IN
cord-263645-wupre5uj	25	12	biological	biological	JJ
cord-263645-wupre5uj	25	13	systems	system	NNS
cord-263645-wupre5uj	25	14	;	;	:
cord-263645-wupre5uj	25	15	however	however	RB
cord-263645-wupre5uj	25	16	,	,	,
cord-263645-wupre5uj	25	17	the	the	DT
cord-263645-wupre5uj	25	18	limited	limited	JJ
cord-263645-wupre5uj	25	19	examples	example	NNS
cord-263645-wupre5uj	25	20	over	over	IN
cord-263645-wupre5uj	25	21	years	year	NNS
cord-263645-wupre5uj	25	22	of	of	IN
cord-263645-wupre5uj	25	23	effort	effort	NN
cord-263645-wupre5uj	25	24	highlight	highlight	VBP
cord-263645-wupre5uj	25	25	the	the	DT
cord-263645-wupre5uj	25	26	challenges	challenge	NNS
cord-263645-wupre5uj	25	27	associated	associate	VBN
cord-263645-wupre5uj	25	28	with	with	IN
cord-263645-wupre5uj	25	29	selectively	selectively	RB
cord-263645-wupre5uj	25	30	probing	probe	VBG
cord-263645-wupre5uj	25	31	RNA	RNA	NNP
cord-263645-wupre5uj	25	32	.	.	.
cord-263645-wupre5uj	26	1	Recently	recently	RB
cord-263645-wupre5uj	26	2	,	,	,
cord-263645-wupre5uj	26	3	we	-PRON-	PRP
cord-263645-wupre5uj	26	4	compiled	compile	VBD
cord-263645-wupre5uj	26	5	the	the	DT
cord-263645-wupre5uj	26	6	RNA	RNA	NNP
cord-263645-wupre5uj	26	7	-	-	HYPH
cord-263645-wupre5uj	26	8	targeted	target	VBN
cord-263645-wupre5uj	26	9	BIoactive	BIoactive	NNP
cord-263645-wupre5uj	26	10	ligaNd	ligand	NN
cord-263645-wupre5uj	26	11	Database	database	NN
cord-263645-wupre5uj	26	12	(	(	-LRB-
cord-263645-wupre5uj	26	13	R	R	NNP
cord-263645-wupre5uj	26	14	-	-	HYPH
cord-263645-wupre5uj	26	15	BIND	BIND	NNP
cord-263645-wupre5uj	26	16	)	)	-RRB-
cord-263645-wupre5uj	26	17	,	,	,
cord-263645-wupre5uj	26	18	which	which	WDT
cord-263645-wupre5uj	26	19	comprised	comprise	VBD
cord-263645-wupre5uj	26	20	organic	organic	JJ
cord-263645-wupre5uj	26	21	small	small	JJ
cord-263645-wupre5uj	26	22	molecules	molecule	NNS
cord-263645-wupre5uj	26	23	that	that	WDT
cord-263645-wupre5uj	26	24	target	target	VBP
cord-263645-wupre5uj	26	25	non	non	JJ
cord-263645-wupre5uj	26	26	-	-	JJ
cord-263645-wupre5uj	26	27	ribosomal	ribosomal	JJ
cord-263645-wupre5uj	26	28	RNAs	rna	NNS
cord-263645-wupre5uj	26	29	and	and	CC
cord-263645-wupre5uj	26	30	show	show	VBP
cord-263645-wupre5uj	26	31	activity	activity	NN
cord-263645-wupre5uj	26	32	in	in	IN
cord-263645-wupre5uj	26	33	cell	cell	NN
cord-263645-wupre5uj	26	34	culture	culture	NN
cord-263645-wupre5uj	26	35	or	or	CC
cord-263645-wupre5uj	26	36	animal	animal	NN
cord-263645-wupre5uj	26	37	models	model	NNS
cord-263645-wupre5uj	26	38	(	(	-LRB-
cord-263645-wupre5uj	26	39	22	22	CD
cord-263645-wupre5uj	26	40	)	)	-RRB-
cord-263645-wupre5uj	26	41	.	.	.
cord-263645-wupre5uj	27	1	For	for	IN
cord-263645-wupre5uj	27	2	this	this	DT
cord-263645-wupre5uj	27	3	Survey	Survey	NNP
cord-263645-wupre5uj	27	4	,	,	,
cord-263645-wupre5uj	27	5	the	the	DT
cord-263645-wupre5uj	27	6	compilation	compilation	NN
cord-263645-wupre5uj	27	7	was	be	VBD
cord-263645-wupre5uj	27	8	updated	update	VBN
cord-263645-wupre5uj	27	9	to	to	TO
cord-263645-wupre5uj	27	10	include	include	VB
cord-263645-wupre5uj	27	11	chemical	chemical	NN
cord-263645-wupre5uj	27	12	probe	probe	NN
cord-263645-wupre5uj	27	13	discoveries	discovery	NNS
cord-263645-wupre5uj	27	14	through	through	IN
cord-263645-wupre5uj	27	15	May	May	NNP
cord-263645-wupre5uj	27	16	2017	2017	CD
cord-263645-wupre5uj	27	17	for	for	IN
cord-263645-wupre5uj	27	18	a	a	DT
cord-263645-wupre5uj	27	19	total	total	NN
cord-263645-wupre5uj	27	20	of	of	IN
cord-263645-wupre5uj	27	21	116	116	CD
cord-263645-wupre5uj	27	22	chemical	chemical	NN
cord-263645-wupre5uj	27	23	probes	probe	NNS
cord-263645-wupre5uj	27	24	(	(	-LRB-
cord-263645-wupre5uj	27	25	see	see	VB
cord-263645-wupre5uj	27	26	Supplementary	Supplementary	NNP
cord-263645-wupre5uj	27	27	Material	Material	NNP
cord-263645-wupre5uj	27	28	,	,	,
cord-263645-wupre5uj	27	29	R	R	NNP
cord-263645-wupre5uj	27	30	-	-	HYPH
cord-263645-wupre5uj	27	31	BIND	BIND	NNP
cord-263645-wupre5uj	27	32	1-1.xls	1-1.xls	CD
cord-263645-wupre5uj	27	33	)	)	-RRB-
cord-263645-wupre5uj	27	34	.	.	.
cord-263645-wupre5uj	28	1	Aminoglycosides	aminoglycoside	NNS
cord-263645-wupre5uj	28	2	are	be	VBP
cord-263645-wupre5uj	28	3	excluded	exclude	VBN
cord-263645-wupre5uj	28	4	due	due	IN
cord-263645-wupre5uj	28	5	to	to	IN
cord-263645-wupre5uj	28	6	established	establish	VBN
cord-263645-wupre5uj	28	7	non	non	JJ
cord-263645-wupre5uj	28	8	-	-	JJ
cord-263645-wupre5uj	28	9	specific	specific	JJ
cord-263645-wupre5uj	28	10	binding	bind	VBG
cord-263645-wupre5uj	28	11	behavior	behavior	NN
cord-263645-wupre5uj	28	12	(	(	-LRB-
cord-263645-wupre5uj	28	13	23	23	CD
cord-263645-wupre5uj	28	14	)	)	-RRB-
cord-263645-wupre5uj	28	15	(	(	-LRB-
cord-263645-wupre5uj	28	16	24	24	CD
cord-263645-wupre5uj	28	17	)	)	-RRB-
cord-263645-wupre5uj	28	18	(	(	-LRB-
cord-263645-wupre5uj	28	19	25	25	CD
cord-263645-wupre5uj	28	20	)	)	-RRB-
cord-263645-wupre5uj	28	21	as	as	RB
cord-263645-wupre5uj	28	22	well	well	RB
cord-263645-wupre5uj	28	23	as	as	IN
cord-263645-wupre5uj	28	24	peptides	peptide	NNS
cord-263645-wupre5uj	28	25	and	and	CC
cord-263645-wupre5uj	28	26	oligonucleotides	oligonucleotide	NNS
cord-263645-wupre5uj	28	27	due	due	JJ
cord-263645-wupre5uj	28	28	to	to	IN
cord-263645-wupre5uj	28	29	distinctive	distinctive	JJ
cord-263645-wupre5uj	28	30	medicinal	medicinal	JJ
cord-263645-wupre5uj	28	31	chemistry	chemistry	NN
cord-263645-wupre5uj	28	32	properties	property	NNS
cord-263645-wupre5uj	28	33	(	(	-LRB-
cord-263645-wupre5uj	28	34	26	26	CD
cord-263645-wupre5uj	28	35	,	,	,
cord-263645-wupre5uj	28	36	27	27	CD
cord-263645-wupre5uj	28	37	)	)	-RRB-
cord-263645-wupre5uj	28	38	.	.	.
cord-263645-wupre5uj	29	1	The	the	DT
cord-263645-wupre5uj	29	2	chemical	chemical	NN
cord-263645-wupre5uj	29	3	probes	probe	NNS
cord-263645-wupre5uj	29	4	were	be	VBD
cord-263645-wupre5uj	29	5	divided	divide	VBN
cord-263645-wupre5uj	29	6	into	into	IN
cord-263645-wupre5uj	29	7	two	two	CD
cord-263645-wupre5uj	29	8	classes	class	NNS
cord-263645-wupre5uj	29	9	:	:	:
cord-263645-wupre5uj	29	10	monovalent	monovalent	JJ
cord-263645-wupre5uj	29	11	,	,	,
cord-263645-wupre5uj	29	12	traditional	traditional	JJ
cord-263645-wupre5uj	29	13	drug	drug	NN
cord-263645-wupre5uj	29	14	-	-	HYPH
cord-263645-wupre5uj	29	15	like	like	JJ
cord-263645-wupre5uj	29	16	small	small	JJ
cord-263645-wupre5uj	29	17	molecules	molecule	NNS
cord-263645-wupre5uj	29	18	(	(	-LRB-
cord-263645-wupre5uj	29	19	SM	SM	NNP
cord-263645-wupre5uj	29	20	)	)	-RRB-
cord-263645-wupre5uj	29	21	and	and	CC
cord-263645-wupre5uj	29	22	multivalent	multivalent	JJ
cord-263645-wupre5uj	29	23	ligands	ligand	NNS
cord-263645-wupre5uj	29	24	(	(	-LRB-
cord-263645-wupre5uj	29	25	MV	MV	NNP
cord-263645-wupre5uj	29	26	)	)	-RRB-
cord-263645-wupre5uj	29	27	with	with	IN
cord-263645-wupre5uj	29	28	alkyl	alkyl	NN
cord-263645-wupre5uj	29	29	,	,	,
cord-263645-wupre5uj	29	30	aryl	aryl	NN
cord-263645-wupre5uj	29	31	,	,	,
cord-263645-wupre5uj	29	32	or	or	CC
cord-263645-wupre5uj	29	33	peptidyl	peptidyl	JJ
cord-263645-wupre5uj	29	34	linkers	linker	NNS
cord-263645-wupre5uj	29	35	between	between	IN
cord-263645-wupre5uj	29	36	multiple	multiple	JJ
cord-263645-wupre5uj	29	37	binding	binding	NN
cord-263645-wupre5uj	29	38	moieties	moiety	NNS
cord-263645-wupre5uj	29	39	.	.	.
cord-263645-wupre5uj	30	1	Previous	previous	JJ
cord-263645-wupre5uj	30	2	work	work	NN
cord-263645-wupre5uj	30	3	compared	compare	VBD
cord-263645-wupre5uj	30	4	the	the	DT
cord-263645-wupre5uj	30	5	physicochemical	physicochemical	JJ
cord-263645-wupre5uj	30	6	,	,	,
cord-263645-wupre5uj	30	7	structural	structural	JJ
cord-263645-wupre5uj	30	8	,	,	,
cord-263645-wupre5uj	30	9	and	and	CC
cord-263645-wupre5uj	30	10	spatial	spatial	JJ
cord-263645-wupre5uj	30	11	properties	property	NNS
cord-263645-wupre5uj	30	12	of	of	IN
cord-263645-wupre5uj	30	13	the	the	DT
cord-263645-wupre5uj	30	14	small	small	JJ
cord-263645-wupre5uj	30	15	molecules	molecule	NNS
cord-263645-wupre5uj	30	16	to	to	IN
cord-263645-wupre5uj	30	17	FDAapproved	fdaapproved	JJ
cord-263645-wupre5uj	30	18	drugs	drug	NNS
cord-263645-wupre5uj	30	19	as	as	RB
cord-263645-wupre5uj	30	20	well	well	RB
cord-263645-wupre5uj	30	21	as	as	IN
cord-263645-wupre5uj	30	22	RNA	rna	NN
cord-263645-wupre5uj	30	23	-	-	HYPH
cord-263645-wupre5uj	30	24	binding	bind	VBG
cord-263645-wupre5uj	30	25	ligands	ligand	NNS
cord-263645-wupre5uj	30	26	without	without	IN
cord-263645-wupre5uj	30	27	reported	report	VBN
cord-263645-wupre5uj	30	28	biological	biological	JJ
cord-263645-wupre5uj	30	29	activity	activity	NN
cord-263645-wupre5uj	30	30	(	(	-LRB-
cord-263645-wupre5uj	30	31	22	22	CD
cord-263645-wupre5uj	30	32	)	)	-RRB-
cord-263645-wupre5uj	30	33	.	.	.
cord-263645-wupre5uj	31	1	This	this	DT
cord-263645-wupre5uj	31	2	analysis	analysis	NN
cord-263645-wupre5uj	31	3	revealed	reveal	VBD
cord-263645-wupre5uj	31	4	several	several	JJ
cord-263645-wupre5uj	31	5	key	key	JJ
cord-263645-wupre5uj	31	6	differences	difference	NNS
cord-263645-wupre5uj	31	7	between	between	IN
cord-263645-wupre5uj	31	8	these	these	DT
cord-263645-wupre5uj	31	9	libraries	library	NNS
cord-263645-wupre5uj	31	10	that	that	WDT
cord-263645-wupre5uj	31	11	can	can	MD
cord-263645-wupre5uj	31	12	in	in	IN
cord-263645-wupre5uj	31	13	turn	turn	NN
cord-263645-wupre5uj	31	14	be	be	VB
cord-263645-wupre5uj	31	15	used	use	VBN
cord-263645-wupre5uj	31	16	to	to	TO
cord-263645-wupre5uj	31	17	bias	bias	VB
cord-263645-wupre5uj	31	18	small	small	JJ
cord-263645-wupre5uj	31	19	molecules	molecule	NNS
cord-263645-wupre5uj	31	20	toward	toward	IN
cord-263645-wupre5uj	31	21	biological	biological	JJ
cord-263645-wupre5uj	31	22	RNA	RNA	NNP
cord-263645-wupre5uj	31	23	targeting	targeting	NN
cord-263645-wupre5uj	31	24	.	.	.
cord-263645-wupre5uj	32	1	In	in	IN
cord-263645-wupre5uj	32	2	addition	addition	NN
cord-263645-wupre5uj	32	3	to	to	IN
cord-263645-wupre5uj	32	4	that	that	DT
cord-263645-wupre5uj	32	5	work	work	NN
cord-263645-wupre5uj	32	6	,	,	,
cord-263645-wupre5uj	32	7	the	the	DT
cord-263645-wupre5uj	32	8	curation	curation	NN
cord-263645-wupre5uj	32	9	of	of	IN
cord-263645-wupre5uj	32	10	this	this	DT
cord-263645-wupre5uj	32	11	collection	collection	NN
cord-263645-wupre5uj	32	12	allowed	allow	VBD
cord-263645-wupre5uj	32	13	us	-PRON-	PRP
cord-263645-wupre5uj	32	14	to	to	TO
cord-263645-wupre5uj	32	15	gain	gain	VB
cord-263645-wupre5uj	32	16	insights	insight	NNS
cord-263645-wupre5uj	32	17	into	into	IN
cord-263645-wupre5uj	32	18	:	:	:
cord-263645-wupre5uj	32	19	(	(	-LRB-
cord-263645-wupre5uj	32	20	i	i	NN
cord-263645-wupre5uj	32	21	)	)	-RRB-
cord-263645-wupre5uj	33	1	the	the	DT
cord-263645-wupre5uj	33	2	RNA	RNA	NNP
cord-263645-wupre5uj	33	3	elements	element	NNS
cord-263645-wupre5uj	33	4	targeted	target	VBN
cord-263645-wupre5uj	33	5	;	;	:
cord-263645-wupre5uj	33	6	(	(	-LRB-
cord-263645-wupre5uj	33	7	ii	ii	NN
cord-263645-wupre5uj	33	8	)	)	-RRB-
cord-263645-wupre5uj	33	9	the	the	DT
cord-263645-wupre5uj	33	10	design	design	NN
cord-263645-wupre5uj	33	11	and	and	CC
cord-263645-wupre5uj	33	12	discovery	discovery	NN
cord-263645-wupre5uj	33	13	strategies	strategy	NNS
cord-263645-wupre5uj	33	14	utilized	utilize	VBN
cord-263645-wupre5uj	33	15	and	and	CC
cord-263645-wupre5uj	33	16	(	(	-LRB-
cord-263645-wupre5uj	33	17	iii	iii	NN
cord-263645-wupre5uj	33	18	)	)	-RRB-
cord-263645-wupre5uj	34	1	the	the	DT
cord-263645-wupre5uj	34	2	in	in	IN
cord-263645-wupre5uj	34	3	cellulo	cellulo	JJ
cord-263645-wupre5uj	34	4	characterization	characterization	NN
cord-263645-wupre5uj	34	5	of	of	IN
cord-263645-wupre5uj	34	6	these	these	DT
cord-263645-wupre5uj	34	7	chemical	chemical	JJ
cord-263645-wupre5uj	34	8	probes	probe	NNS
cord-263645-wupre5uj	34	9	.	.	.
cord-263645-wupre5uj	35	1	Herein	herein	RB
cord-263645-wupre5uj	35	2	,	,	,
cord-263645-wupre5uj	35	3	we	-PRON-	PRP
cord-263645-wupre5uj	35	4	discuss	discuss	VBP
cord-263645-wupre5uj	35	5	these	these	DT
cord-263645-wupre5uj	35	6	insights	insight	NNS
cord-263645-wupre5uj	35	7	,	,	,
cord-263645-wupre5uj	35	8	highlight	highlight	VBP
cord-263645-wupre5uj	35	9	unique	unique	JJ
cord-263645-wupre5uj	35	10	examples	example	NNS
cord-263645-wupre5uj	35	11	,	,	,
cord-263645-wupre5uj	35	12	and	and	CC
cord-263645-wupre5uj	35	13	consider	consider	VB
cord-263645-wupre5uj	35	14	the	the	DT
cord-263645-wupre5uj	35	15	need	need	NN
cord-263645-wupre5uj	35	16	to	to	TO
cord-263645-wupre5uj	35	17	establish	establish	VB
cord-263645-wupre5uj	35	18	standards	standard	NNS
cord-263645-wupre5uj	35	19	for	for	IN
cord-263645-wupre5uj	35	20	cellbased	cellbased	JJ
cord-263645-wupre5uj	35	21	selectivity	selectivity	NN
cord-263645-wupre5uj	35	22	.	.	.
cord-263645-wupre5uj	36	1	We	-PRON-	PRP
cord-263645-wupre5uj	36	2	conclude	conclude	VBP
cord-263645-wupre5uj	36	3	by	by	IN
cord-263645-wupre5uj	36	4	proposing	propose	VBG
cord-263645-wupre5uj	36	5	future	future	JJ
cord-263645-wupre5uj	36	6	directions	direction	NNS
cord-263645-wupre5uj	36	7	that	that	WDT
cord-263645-wupre5uj	36	8	utilize	utilize	VBP
cord-263645-wupre5uj	36	9	our	-PRON-	PRP$
cord-263645-wupre5uj	36	10	current	current	JJ
cord-263645-wupre5uj	36	11	and	and	CC
cord-263645-wupre5uj	36	12	prospective	prospective	JJ
cord-263645-wupre5uj	36	13	chemical	chemical	NN
cord-263645-wupre5uj	36	14	biology	biology	NN
cord-263645-wupre5uj	36	15	toolbox	toolbox	NN
cord-263645-wupre5uj	36	16	to	to	TO
cord-263645-wupre5uj	36	17	expedite	expedite	VB
cord-263645-wupre5uj	36	18	the	the	DT
cord-263645-wupre5uj	36	19	discovery	discovery	NN
cord-263645-wupre5uj	36	20	of	of	IN
cord-263645-wupre5uj	36	21	chemical	chemical	JJ
cord-263645-wupre5uj	36	22	probes	probe	NNS
cord-263645-wupre5uj	36	23	for	for	IN
cord-263645-wupre5uj	36	24	RNA	RNA	NNP
cord-263645-wupre5uj	36	25	.	.	.
cord-263645-wupre5uj	37	1	The	the	DT
cord-263645-wupre5uj	37	2	116	116	CD
cord-263645-wupre5uj	37	3	chemical	chemical	NN
cord-263645-wupre5uj	37	4	probes	probe	NNS
cord-263645-wupre5uj	37	5	targeted	target	VBD
cord-263645-wupre5uj	37	6	33	33	CD
cord-263645-wupre5uj	37	7	distinct	distinct	JJ
cord-263645-wupre5uj	37	8	RNA	RNA	NNP
cord-263645-wupre5uj	37	9	elements	element	NNS
cord-263645-wupre5uj	37	10	,	,	,
cord-263645-wupre5uj	37	11	including	include	VBG
cord-263645-wupre5uj	37	12	those	those	DT
cord-263645-wupre5uj	37	13	from	from	IN
cord-263645-wupre5uj	37	14	bacterial	bacterial	JJ
cord-263645-wupre5uj	37	15	,	,	,
cord-263645-wupre5uj	37	16	fungal	fungal	JJ
cord-263645-wupre5uj	37	17	,	,	,
cord-263645-wupre5uj	37	18	human	human	JJ
cord-263645-wupre5uj	37	19	,	,	,
cord-263645-wupre5uj	37	20	or	or	CC
cord-263645-wupre5uj	37	21	viral	viral	JJ
cord-263645-wupre5uj	37	22	systems	system	NNS
cord-263645-wupre5uj	37	23	[	[	-LRB-
cord-263645-wupre5uj	37	24	Figure	figure	NN
cord-263645-wupre5uj	37	25	1	1	CD
cord-263645-wupre5uj	37	26	]	]	-RRB-
cord-263645-wupre5uj	37	27	.	.	.
cord-263645-wupre5uj	38	1	Although	although	IN
cord-263645-wupre5uj	38	2	some	some	DT
cord-263645-wupre5uj	38	3	overlap	overlap	NN
cord-263645-wupre5uj	38	4	between	between	IN
cord-263645-wupre5uj	38	5	targets	target	NNS
cord-263645-wupre5uj	38	6	was	be	VBD
cord-263645-wupre5uj	38	7	observed	observe	VBN
cord-263645-wupre5uj	38	8	,	,	,
cord-263645-wupre5uj	38	9	the	the	DT
cord-263645-wupre5uj	38	10	small	small	JJ
cord-263645-wupre5uj	38	11	molecules	molecule	NNS
cord-263645-wupre5uj	38	12	probed	probe	VBD
cord-263645-wupre5uj	38	13	a	a	DT
cord-263645-wupre5uj	38	14	wider	wide	JJR
cord-263645-wupre5uj	38	15	range	range	NN
cord-263645-wupre5uj	38	16	of	of	IN
cord-263645-wupre5uj	38	17	RNAs	rna	NNS
cord-263645-wupre5uj	38	18	in	in	IN
cord-263645-wupre5uj	38	19	cell	cell	NN
cord-263645-wupre5uj	38	20	culture	culture	NN
cord-263645-wupre5uj	38	21	than	than	IN
cord-263645-wupre5uj	38	22	the	the	DT
cord-263645-wupre5uj	38	23	multivalent	multivalent	JJ
cord-263645-wupre5uj	38	24	ligands	ligand	NNS
cord-263645-wupre5uj	38	25	[	[	-LRB-
cord-263645-wupre5uj	38	26	Figure	figure	NN
cord-263645-wupre5uj	38	27	1A	1a	NN
cord-263645-wupre5uj	38	28	]	]	-RRB-
cord-263645-wupre5uj	38	29	.	.	.
cord-263645-wupre5uj	39	1	The	the	DT
cord-263645-wupre5uj	39	2	most	most	RBS
cord-263645-wupre5uj	39	3	common	common	JJ
cord-263645-wupre5uj	39	4	small	small	JJ
cord-263645-wupre5uj	39	5	molecule	molecule	NN
cord-263645-wupre5uj	39	6	target	target	NN
cord-263645-wupre5uj	39	7	was	be	VBD
cord-263645-wupre5uj	39	8	the	the	DT
cord-263645-wupre5uj	39	9	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	39	10	Trans	Trans	NNP
cord-263645-wupre5uj	39	11	-	-	NNP
cord-263645-wupre5uj	39	12	activation	activation	NN
cord-263645-wupre5uj	39	13	response	response	NN
cord-263645-wupre5uj	39	14	element	element	NN
cord-263645-wupre5uj	39	15	(	(	-LRB-
cord-263645-wupre5uj	39	16	TAR	tar	NN
cord-263645-wupre5uj	39	17	)	)	-RRB-
cord-263645-wupre5uj	39	18	RNA	RNA	NNP
cord-263645-wupre5uj	39	19	,	,	,
cord-263645-wupre5uj	39	20	a	a	DT
cord-263645-wupre5uj	39	21	well	well	RB
cord-263645-wupre5uj	39	22	-	-	HYPH
cord-263645-wupre5uj	39	23	studied	study	VBN
cord-263645-wupre5uj	39	24	and	and	CC
cord-263645-wupre5uj	39	25	frequently	frequently	RB
cord-263645-wupre5uj	39	26	screened	screen	VBD
cord-263645-wupre5uj	39	27	RNA	RNA	NNP
cord-263645-wupre5uj	39	28	that	that	WDT
cord-263645-wupre5uj	39	29	binds	bind	VBZ
cord-263645-wupre5uj	39	30	to	to	IN
cord-263645-wupre5uj	39	31	the	the	DT
cord-263645-wupre5uj	39	32	viral	viral	JJ
cord-263645-wupre5uj	39	33	protein	protein	NN
cord-263645-wupre5uj	39	34	Tat	Tat	NNP
cord-263645-wupre5uj	39	35	(	(	-LRB-
cord-263645-wupre5uj	39	36	23	23	CD
cord-263645-wupre5uj	39	37	)	)	-RRB-
cord-263645-wupre5uj	39	38	.	.	.
cord-263645-wupre5uj	40	1	Disruption	disruption	NN
cord-263645-wupre5uj	40	2	of	of	IN
cord-263645-wupre5uj	40	3	this	this	DT
cord-263645-wupre5uj	40	4	interaction	interaction	NN
cord-263645-wupre5uj	40	5	reduces	reduce	VBZ
cord-263645-wupre5uj	40	6	viral	viral	JJ
cord-263645-wupre5uj	40	7	production	production	NN
cord-263645-wupre5uj	40	8	and	and	CC
cord-263645-wupre5uj	40	9	represents	represent	VBZ
cord-263645-wupre5uj	40	10	an	an	DT
cord-263645-wupre5uj	40	11	alternative	alternative	JJ
cord-263645-wupre5uj	40	12	strategy	strategy	NN
cord-263645-wupre5uj	40	13	against	against	IN
cord-263645-wupre5uj	40	14	HIV	HIV	NNP
cord-263645-wupre5uj	40	15	.	.	.
cord-263645-wupre5uj	41	1	Some	some	DT
cord-263645-wupre5uj	41	2	of	of	IN
cord-263645-wupre5uj	41	3	the	the	DT
cord-263645-wupre5uj	41	4	first	first	JJ
cord-263645-wupre5uj	41	5	RNA	RNA	NNP
cord-263645-wupre5uj	41	6	-	-	HYPH
cord-263645-wupre5uj	41	7	targeted	target	VBN
cord-263645-wupre5uj	41	8	chemical	chemical	NN
cord-263645-wupre5uj	41	9	probes	probe	NNS
cord-263645-wupre5uj	41	10	were	be	VBD
cord-263645-wupre5uj	41	11	developed	develop	VBN
cord-263645-wupre5uj	41	12	for	for	IN
cord-263645-wupre5uj	41	13	TAR	TAR	NNP
cord-263645-wupre5uj	41	14	RNA	RNA	NNP
cord-263645-wupre5uj	41	15	,	,	,
cord-263645-wupre5uj	41	16	including	include	VBG
cord-263645-wupre5uj	41	17	a	a	DT
cord-263645-wupre5uj	41	18	tetraaminoquinozaline	tetraaminoquinozaline	NN
cord-263645-wupre5uj	41	19	(	(	-LRB-
cord-263645-wupre5uj	41	20	28	28	CD
cord-263645-wupre5uj	41	21	)	)	-RRB-
cord-263645-wupre5uj	41	22	and	and	CC
cord-263645-wupre5uj	41	23	a	a	DT
cord-263645-wupre5uj	41	24	6-aminoquinolone	6-aminoquinolone	CD
cord-263645-wupre5uj	41	25	(	(	-LRB-
cord-263645-wupre5uj	41	26	29	29	CD
cord-263645-wupre5uj	41	27	,	,	,
cord-263645-wupre5uj	41	28	30	30	CD
cord-263645-wupre5uj	41	29	)	)	-RRB-
cord-263645-wupre5uj	41	30	with	with	IN
cord-263645-wupre5uj	41	31	an	an	DT
cord-263645-wupre5uj	41	32	EC	EC	NNP
cord-263645-wupre5uj	41	33	50	50	CD
cord-263645-wupre5uj	41	34	value	value	NN
cord-263645-wupre5uj	41	35	of	of	IN
cord-263645-wupre5uj	41	36	16	16	CD
cord-263645-wupre5uj	41	37	M	M	NNP
cord-263645-wupre5uj	41	38	and	and	CC
cord-263645-wupre5uj	41	39	an	an	DT
cord-263645-wupre5uj	41	40	IC	IC	NNP
cord-263645-wupre5uj	41	41	50	50	CD
cord-263645-wupre5uj	41	42	value	value	NN
cord-263645-wupre5uj	41	43	of	of	IN
cord-263645-wupre5uj	41	44	0.85	0.85	CD
cord-263645-wupre5uj	41	45	M	M	NNP
cord-263645-wupre5uj	41	46	,	,	,
cord-263645-wupre5uj	41	47	respectively	respectively	RB
cord-263645-wupre5uj	41	48	,	,	,
cord-263645-wupre5uj	41	49	in	in	IN
cord-263645-wupre5uj	41	50	chronically	chronically	RB
cord-263645-wupre5uj	41	51	infected	infect	VBN
cord-263645-wupre5uj	41	52	HIV	HIV	NNP
cord-263645-wupre5uj	41	53	cell	cell	NN
cord-263645-wupre5uj	41	54	models	model	NNS
cord-263645-wupre5uj	41	55	.	.	.
cord-263645-wupre5uj	42	1	On	on	IN
cord-263645-wupre5uj	42	2	the	the	DT
cord-263645-wupre5uj	42	3	other	other	JJ
cord-263645-wupre5uj	42	4	hand	hand	NN
cord-263645-wupre5uj	42	5	,	,	,
cord-263645-wupre5uj	42	6	only	only	RB
cord-263645-wupre5uj	42	7	one	one	CD
cord-263645-wupre5uj	42	8	bioactive	bioactive	JJ
cord-263645-wupre5uj	42	9	small	small	JJ
cord-263645-wupre5uj	42	10	molecule	molecule	NN
cord-263645-wupre5uj	42	11	was	be	VBD
cord-263645-wupre5uj	42	12	identified	identify	VBN
cord-263645-wupre5uj	42	13	for	for	IN
cord-263645-wupre5uj	42	14	a	a	DT
cord-263645-wupre5uj	42	15	fungal	fungal	JJ
cord-263645-wupre5uj	42	16	target	target	NN
cord-263645-wupre5uj	42	17	,	,	,
cord-263645-wupre5uj	42	18	specifically	specifically	RB
cord-263645-wupre5uj	42	19	the	the	DT
cord-263645-wupre5uj	42	20	Candida	Candida	NNP
cord-263645-wupre5uj	42	21	albicans	albican	NNS
cord-263645-wupre5uj	42	22	LSU	LSU	NNP
cord-263645-wupre5uj	42	23	Group	Group	NNP
cord-263645-wupre5uj	42	24	1	1	CD
cord-263645-wupre5uj	42	25	Ribozyme	Ribozyme	NNPS
cord-263645-wupre5uj	42	26	(	(	-LRB-
cord-263645-wupre5uj	42	27	31	31	CD
cord-263645-wupre5uj	42	28	)	)	-RRB-
cord-263645-wupre5uj	42	29	.	.	.
cord-263645-wupre5uj	43	1	This	this	DT
cord-263645-wupre5uj	43	2	essential	essential	JJ
cord-263645-wupre5uj	43	3	ribozyme	ribozyme	NN
cord-263645-wupre5uj	43	4	is	be	VBZ
cord-263645-wupre5uj	43	5	a	a	DT
cord-263645-wupre5uj	43	6	desirable	desirable	JJ
cord-263645-wupre5uj	43	7	antifungal	antifungal	JJ
cord-263645-wupre5uj	43	8	target	target	NN
cord-263645-wupre5uj	43	9	as	as	IN
cord-263645-wupre5uj	43	10	it	-PRON-	PRP
cord-263645-wupre5uj	43	11	leads	lead	VBZ
cord-263645-wupre5uj	43	12	to	to	TO
cord-263645-wupre5uj	43	13	failed	fail	VBN
cord-263645-wupre5uj	43	14	ribosomal	ribosomal	JJ
cord-263645-wupre5uj	43	15	assembly	assembly	NN
cord-263645-wupre5uj	43	16	when	when	WRB
cord-263645-wupre5uj	43	17	mutated	mutate	VBN
cord-263645-wupre5uj	43	18	and	and	CC
cord-263645-wupre5uj	43	19	is	be	VBZ
cord-263645-wupre5uj	43	20	absent	absent	JJ
cord-263645-wupre5uj	43	21	in	in	IN
cord-263645-wupre5uj	43	22	the	the	DT
cord-263645-wupre5uj	43	23	human	human	JJ
cord-263645-wupre5uj	43	24	genome	genome	NN
cord-263645-wupre5uj	43	25	.	.	.
cord-263645-wupre5uj	44	1	Further	further	RB
cord-263645-wupre5uj	44	2	,	,	,
cord-263645-wupre5uj	44	3	10/75	10/75	CD
cord-263645-wupre5uj	44	4	small	small	JJ
cord-263645-wupre5uj	44	5	molecule	molecule	NN
cord-263645-wupre5uj	44	6	chemical	chemical	NN
cord-263645-wupre5uj	44	7	probes	probe	NNS
cord-263645-wupre5uj	44	8	demonstrated	demonstrate	VBD
cord-263645-wupre5uj	44	9	efficacy	efficacy	NN
cord-263645-wupre5uj	44	10	in	in	IN
cord-263645-wupre5uj	44	11	animal	animal	NN
cord-263645-wupre5uj	44	12	models	model	NNS
cord-263645-wupre5uj	44	13	,	,	,
cord-263645-wupre5uj	44	14	targeting	target	VBG
cord-263645-wupre5uj	44	15	seven	seven	CD
cord-263645-wupre5uj	44	16	unique	unique	JJ
cord-263645-wupre5uj	44	17	RNA	RNA	NNP
cord-263645-wupre5uj	44	18	elements	element	NNS
cord-263645-wupre5uj	44	19	in	in	IN
cord-263645-wupre5uj	44	20	bacterial	bacterial	JJ
cord-263645-wupre5uj	44	21	and	and	CC
cord-263645-wupre5uj	44	22	human	human	JJ
cord-263645-wupre5uj	44	23	systems	system	NNS
cord-263645-wupre5uj	44	24	.	.	.
cord-263645-wupre5uj	45	1	One	one	CD
cord-263645-wupre5uj	45	2	recent	recent	JJ
cord-263645-wupre5uj	45	3	example	example	NN
cord-263645-wupre5uj	45	4	(	(	-LRB-
cord-263645-wupre5uj	45	5	19	19	CD
cord-263645-wupre5uj	45	6	)	)	-RRB-
cord-263645-wupre5uj	45	7	targeted	target	VBD
cord-263645-wupre5uj	45	8	the	the	DT
cord-263645-wupre5uj	45	9	G	G	NNP
cord-263645-wupre5uj	45	10	-	-	HYPH
cord-263645-wupre5uj	45	11	quadruplex	quadruplex	NNP
cord-263645-wupre5uj	45	12	structure	structure	NN
cord-263645-wupre5uj	45	13	located	locate	VBN
cord-263645-wupre5uj	45	14	in	in	IN
cord-263645-wupre5uj	45	15	the	the	DT
cord-263645-wupre5uj	45	16	5	5	CD
cord-263645-wupre5uj	45	17	-untranslated	-untranslated	JJ
cord-263645-wupre5uj	45	18	region	region	NN
cord-263645-wupre5uj	45	19	(	(	-LRB-
cord-263645-wupre5uj	45	20	UTR	UTR	NNP
cord-263645-wupre5uj	45	21	)	)	-RRB-
cord-263645-wupre5uj	45	22	of	of	IN
cord-263645-wupre5uj	45	23	Human	Human	NNP
cord-263645-wupre5uj	45	24	Vascular	Vascular	NNP
cord-263645-wupre5uj	45	25	Endothelial	Endothelial	NNP
cord-263645-wupre5uj	45	26	Growth	Growth	NNP
cord-263645-wupre5uj	45	27	Factor	Factor	NNP
cord-263645-wupre5uj	45	28	(	(	-LRB-
cord-263645-wupre5uj	45	29	hVEGF	hVEGF	NNP
cord-263645-wupre5uj	45	30	)	)	-RRB-
cord-263645-wupre5uj	45	31	mRNA	mRNA	NNP
cord-263645-wupre5uj	45	32	,	,	,
cord-263645-wupre5uj	45	33	an	an	DT
cord-263645-wupre5uj	45	34	angiogenic	angiogenic	JJ
cord-263645-wupre5uj	45	35	growth	growth	NN
cord-263645-wupre5uj	45	36	factor	factor	NN
cord-263645-wupre5uj	45	37	involved	involve	VBN
cord-263645-wupre5uj	45	38	in	in	IN
cord-263645-wupre5uj	45	39	tumor	tumor	NN
cord-263645-wupre5uj	45	40	progression	progression	NN
cord-263645-wupre5uj	45	41	.	.	.
cord-263645-wupre5uj	46	1	In	in	IN
cord-263645-wupre5uj	46	2	a	a	DT
cord-263645-wupre5uj	46	3	breast	breast	NN
cord-263645-wupre5uj	46	4	cancer	cancer	NN
cord-263645-wupre5uj	46	5	mouse	mouse	NN
cord-263645-wupre5uj	46	6	model	model	NN
cord-263645-wupre5uj	46	7	,	,	,
cord-263645-wupre5uj	46	8	the	the	DT
cord-263645-wupre5uj	46	9	small	small	JJ
cord-263645-wupre5uj	46	10	molecule	molecule	NN
cord-263645-wupre5uj	46	11	showed	show	VBD
cord-263645-wupre5uj	46	12	antitumor	antitumor	JJ
cord-263645-wupre5uj	46	13	efficacy	efficacy	NN
cord-263645-wupre5uj	46	14	similar	similar	JJ
cord-263645-wupre5uj	46	15	to	to	IN
cord-263645-wupre5uj	46	16	that	that	DT
cord-263645-wupre5uj	46	17	of	of	IN
cord-263645-wupre5uj	46	18	doxorubicin	doxorubicin	NN
cord-263645-wupre5uj	46	19	but	but	CC
cord-263645-wupre5uj	46	20	with	with	IN
cord-263645-wupre5uj	46	21	fewer	few	JJR
cord-263645-wupre5uj	46	22	indications	indication	NNS
cord-263645-wupre5uj	46	23	of	of	IN
cord-263645-wupre5uj	46	24	side	side	JJ
cord-263645-wupre5uj	46	25	effects	effect	NNS
cord-263645-wupre5uj	46	26	.	.	.
cord-263645-wupre5uj	47	1	Multivalent	multivalent	JJ
cord-263645-wupre5uj	47	2	chemical	chemical	NN
cord-263645-wupre5uj	47	3	probes	probe	NNS
cord-263645-wupre5uj	47	4	targeted	target	VBD
cord-263645-wupre5uj	47	5	fewer	few	JJR
cord-263645-wupre5uj	47	6	distinct	distinct	JJ
cord-263645-wupre5uj	47	7	RNA	RNA	NNP
cord-263645-wupre5uj	47	8	elements	element	NNS
cord-263645-wupre5uj	47	9	,	,	,
cord-263645-wupre5uj	47	10	with	with	IN
cord-263645-wupre5uj	47	11	27/41	27/41	CD
cord-263645-wupre5uj	47	12	unique	unique	JJ
cord-263645-wupre5uj	47	13	ligands	ligand	NNS
cord-263645-wupre5uj	47	14	targeting	target	VBG
cord-263645-wupre5uj	47	15	nucleotide	nucleotide	JJ
cord-263645-wupre5uj	47	16	repeat	repeat	NN
cord-263645-wupre5uj	47	17	expansions	expansion	NNS
cord-263645-wupre5uj	47	18	[	[	-LRB-
cord-263645-wupre5uj	47	19	Figure	figure	NN
cord-263645-wupre5uj	47	20	1B	1b	NN
cord-263645-wupre5uj	47	21	]	]	-RRB-
cord-263645-wupre5uj	47	22	.	.	.
cord-263645-wupre5uj	48	1	There	there	EX
cord-263645-wupre5uj	48	2	are	be	VBP
cord-263645-wupre5uj	48	3	several	several	JJ
cord-263645-wupre5uj	48	4	advantages	advantage	NNS
cord-263645-wupre5uj	48	5	to	to	IN
cord-263645-wupre5uj	48	6	targeting	target	VBG
cord-263645-wupre5uj	48	7	these	these	DT
cord-263645-wupre5uj	48	8	RNA	RNA	NNP
cord-263645-wupre5uj	48	9	repeats	repeat	VBZ
cord-263645-wupre5uj	48	10	:	:	:
cord-263645-wupre5uj	48	11	(	(	-LRB-
cord-263645-wupre5uj	48	12	i	i	NN
cord-263645-wupre5uj	48	13	)	)	-RRB-
cord-263645-wupre5uj	48	14	long	long	JJ
cord-263645-wupre5uj	48	15	repeat	repeat	NN
cord-263645-wupre5uj	48	16	stretches	stretch	NNS
cord-263645-wupre5uj	48	17	are	be	VBP
cord-263645-wupre5uj	48	18	typically	typically	RB
cord-263645-wupre5uj	48	19	not	not	RB
cord-263645-wupre5uj	48	20	present	present	JJ
cord-263645-wupre5uj	48	21	elsewhere	elsewhere	RB
cord-263645-wupre5uj	48	22	in	in	IN
cord-263645-wupre5uj	48	23	the	the	DT
cord-263645-wupre5uj	48	24	human	human	JJ
cord-263645-wupre5uj	48	25	genome	genome	NN
cord-263645-wupre5uj	48	26	;	;	,
cord-263645-wupre5uj	48	27	(	(	-LRB-
cord-263645-wupre5uj	48	28	ii	ii	NN
cord-263645-wupre5uj	48	29	)	)	-RRB-
cord-263645-wupre5uj	48	30	nuclear	nuclear	JJ
cord-263645-wupre5uj	48	31	localization	localization	NN
cord-263645-wupre5uj	48	32	minimizes	minimize	VBZ
cord-263645-wupre5uj	48	33	competition	competition	NN
cord-263645-wupre5uj	48	34	with	with	IN
cord-263645-wupre5uj	48	35	ribosomal	ribosomal	NNP
cord-263645-wupre5uj	48	36	RNA	RNA	NNP
cord-263645-wupre5uj	48	37	and	and	CC
cord-263645-wupre5uj	48	38	(	(	-LRB-
cord-263645-wupre5uj	48	39	iii	iii	NN
cord-263645-wupre5uj	48	40	)	)	-RRB-
cord-263645-wupre5uj	49	1	targetable	targetable	JJ
cord-263645-wupre5uj	49	2	motifs	motif	NNS
cord-263645-wupre5uj	49	3	are	be	VBP
cord-263645-wupre5uj	49	4	separated	separate	VBN
cord-263645-wupre5uj	49	5	by	by	IN
cord-263645-wupre5uj	49	6	a	a	DT
cord-263645-wupre5uj	49	7	specific	specific	JJ
cord-263645-wupre5uj	49	8	distance	distance	NN
cord-263645-wupre5uj	49	9	(	(	-LRB-
cord-263645-wupre5uj	49	10	32	32	CD
cord-263645-wupre5uj	49	11	)	)	-RRB-
cord-263645-wupre5uj	49	12	.	.	.
cord-263645-wupre5uj	50	1	Another	another	DT
cord-263645-wupre5uj	50	2	target	target	NN
cord-263645-wupre5uj	50	3	of	of	IN
cord-263645-wupre5uj	50	4	interest	interest	NN
cord-263645-wupre5uj	50	5	was	be	VBD
cord-263645-wupre5uj	50	6	the	the	DT
cord-263645-wupre5uj	50	7	heat	heat	NN
cord-263645-wupre5uj	50	8	shock	shock	NN
cord-263645-wupre5uj	50	9	response	response	NN
cord-263645-wupre5uj	50	10	element	element	NN
cord-263645-wupre5uj	50	11	of	of	IN
cord-263645-wupre5uj	50	12	the	the	DT
cord-263645-wupre5uj	50	13	32	32	CD
cord-263645-wupre5uj	50	14	factor	factor	NN
cord-263645-wupre5uj	50	15	mRNA	mrna	NN
cord-263645-wupre5uj	50	16	in	in	IN
cord-263645-wupre5uj	50	17	E.	E.	NNP
cord-263645-wupre5uj	50	18	coli	coli	NNS
cord-263645-wupre5uj	50	19	.	.	.
cord-263645-wupre5uj	51	1	This	this	DT
cord-263645-wupre5uj	51	2	RNA	RNA	NNP
cord-263645-wupre5uj	51	3	element	element	NN
cord-263645-wupre5uj	51	4	contains	contain	VBZ
cord-263645-wupre5uj	51	5	a	a	DT
cord-263645-wupre5uj	51	6	rare	rare	JJ
cord-263645-wupre5uj	51	7	,	,	,
cord-263645-wupre5uj	51	8	perfectly	perfectly	RB
cord-263645-wupre5uj	51	9	paired	pair	VBD
cord-263645-wupre5uj	51	10	three	three	CD
cord-263645-wupre5uj	51	11	-	-	HYPH
cord-263645-wupre5uj	51	12	way	way	NN
cord-263645-wupre5uj	51	13	junction	junction	NN
cord-263645-wupre5uj	51	14	that	that	WDT
cord-263645-wupre5uj	51	15	can	can	MD
cord-263645-wupre5uj	51	16	be	be	VB
cord-263645-wupre5uj	51	17	stabilized	stabilize	VBN
cord-263645-wupre5uj	51	18	by	by	IN
cord-263645-wupre5uj	51	19	symmetrical	symmetrical	JJ
cord-263645-wupre5uj	51	20	triptycenebased	triptycenebase	VBN
cord-263645-wupre5uj	51	21	molecules	molecule	NNS
cord-263645-wupre5uj	51	22	,	,	,
cord-263645-wupre5uj	51	23	forming	form	VBG
cord-263645-wupre5uj	51	24	a	a	DT
cord-263645-wupre5uj	51	25	distinct	distinct	JJ
cord-263645-wupre5uj	51	26	shape	shape	NN
cord-263645-wupre5uj	51	27	-	-	HYPH
cord-263645-wupre5uj	51	28	selective	selective	JJ
cord-263645-wupre5uj	51	29	fit	fit	NN
cord-263645-wupre5uj	51	30	(	(	-LRB-
cord-263645-wupre5uj	51	31	33	33	CD
cord-263645-wupre5uj	51	32	)	)	-RRB-
cord-263645-wupre5uj	51	33	.	.	.
cord-263645-wupre5uj	52	1	This	this	DT
cord-263645-wupre5uj	52	2	stabilization	stabilization	NN
cord-263645-wupre5uj	52	3	resulted	result	VBD
cord-263645-wupre5uj	52	4	in	in	IN
cord-263645-wupre5uj	52	5	an	an	DT
cord-263645-wupre5uj	52	6	∼60	∼60	NN
cord-263645-wupre5uj	52	7	%	%	NN
cord-263645-wupre5uj	52	8	reduction	reduction	NN
cord-263645-wupre5uj	52	9	in	in	IN
cord-263645-wupre5uj	52	10	translation	translation	NN
cord-263645-wupre5uj	52	11	of	of	IN
cord-263645-wupre5uj	52	12	an	an	DT
cord-263645-wupre5uj	52	13	32	32	CD
cord-263645-wupre5uj	52	14	-GFP	-GFP	HYPH
cord-263645-wupre5uj	52	15	fusion	fusion	NN
cord-263645-wupre5uj	52	16	protein	protein	NN
cord-263645-wupre5uj	52	17	and	and	CC
cord-263645-wupre5uj	52	18	could	could	MD
cord-263645-wupre5uj	52	19	potentially	potentially	RB
cord-263645-wupre5uj	52	20	lead	lead	VB
cord-263645-wupre5uj	52	21	to	to	IN
cord-263645-wupre5uj	52	22	antimicrobial	antimicrobial	JJ
cord-263645-wupre5uj	52	23	activity	activity	NN
cord-263645-wupre5uj	52	24	(	(	-LRB-
cord-263645-wupre5uj	52	25	34	34	CD
cord-263645-wupre5uj	52	26	)	)	-RRB-
cord-263645-wupre5uj	52	27	.	.	.
cord-263645-wupre5uj	53	1	In	in	IN
cord-263645-wupre5uj	53	2	addition	addition	NN
cord-263645-wupre5uj	53	3	,	,	,
cord-263645-wupre5uj	53	4	7/41	7/41	CD
cord-263645-wupre5uj	53	5	chemical	chemical	NN
cord-263645-wupre5uj	53	6	probes	probe	NNS
cord-263645-wupre5uj	53	7	showed	show	VBD
cord-263645-wupre5uj	53	8	efficacy	efficacy	NN
cord-263645-wupre5uj	53	9	in	in	IN
cord-263645-wupre5uj	53	10	animal	animal	NN
cord-263645-wupre5uj	53	11	models	model	NNS
cord-263645-wupre5uj	53	12	,	,	,
cord-263645-wupre5uj	53	13	targeting	target	VBG
cord-263645-wupre5uj	53	14	two	two	CD
cord-263645-wupre5uj	53	15	RNA	RNA	NNP
cord-263645-wupre5uj	53	16	elements	element	NNS
cord-263645-wupre5uj	53	17	:	:	:
cord-263645-wupre5uj	53	18	r(CUG	r(cug	CD
cord-263645-wupre5uj	53	19	)	)	-RRB-
cord-263645-wupre5uj	53	20	exp	exp	XX
cord-263645-wupre5uj	53	21	repeats	repeat	VBZ
cord-263645-wupre5uj	53	22	and	and	CC
cord-263645-wupre5uj	53	23	pri	pri	NNP
cord-263645-wupre5uj	53	24	-	-	HYPH
cord-263645-wupre5uj	53	25	miRNA-96	miRNA-96	NNP
cord-263645-wupre5uj	53	26	.	.	.
cord-263645-wupre5uj	54	1	Pri	Pri	NNP
cord-263645-wupre5uj	54	2	-	-	HYPH
cord-263645-wupre5uj	54	3	miRNA-96	miRNA-96	NNP
cord-263645-wupre5uj	54	4	is	be	VBZ
cord-263645-wupre5uj	54	5	an	an	DT
cord-263645-wupre5uj	54	6	oncogenic	oncogenic	JJ
cord-263645-wupre5uj	54	7	RNA	rna	NN
cord-263645-wupre5uj	54	8	that	that	WDT
cord-263645-wupre5uj	54	9	suppresses	suppress	VBZ
cord-263645-wupre5uj	54	10	the	the	DT
cord-263645-wupre5uj	54	11	translation	translation	NN
cord-263645-wupre5uj	54	12	of	of	IN
cord-263645-wupre5uj	54	13	a	a	DT
cord-263645-wupre5uj	54	14	pro	pro	JJ
cord-263645-wupre5uj	54	15	-	-	JJ
cord-263645-wupre5uj	54	16	apoptotic	apoptotic	JJ
cord-263645-wupre5uj	54	17	protein	protein	NN
cord-263645-wupre5uj	54	18	,	,	,
cord-263645-wupre5uj	54	19	FOXO1	foxo1	XX
cord-263645-wupre5uj	54	20	.	.	.
cord-263645-wupre5uj	55	1	In	in	IN
cord-263645-wupre5uj	55	2	a	a	DT
cord-263645-wupre5uj	55	3	mouse	mouse	NN
cord-263645-wupre5uj	55	4	model	model	NN
cord-263645-wupre5uj	55	5	of	of	IN
cord-263645-wupre5uj	55	6	triple	triple	JJ
cord-263645-wupre5uj	55	7	negative	negative	JJ
cord-263645-wupre5uj	55	8	breast	breast	NN
cord-263645-wupre5uj	55	9	cancer	cancer	NN
cord-263645-wupre5uj	55	10	,	,	,
cord-263645-wupre5uj	55	11	a	a	DT
cord-263645-wupre5uj	55	12	modular	modular	JJ
cord-263645-wupre5uj	55	13	ligand	ligand	NN
cord-263645-wupre5uj	55	14	designed	design	VBN
cord-263645-wupre5uj	55	15	to	to	TO
cord-263645-wupre5uj	55	16	target	target	VB
cord-263645-wupre5uj	55	17	the	the	DT
cord-263645-wupre5uj	55	18	Drosha	Drosha	NNP
cord-263645-wupre5uj	55	19	processing	processing	NN
cord-263645-wupre5uj	55	20	site	site	NN
cord-263645-wupre5uj	55	21	on	on	IN
cord-263645-wupre5uj	55	22	the	the	DT
cord-263645-wupre5uj	55	23	RNA	RNA	NNP
cord-263645-wupre5uj	55	24	led	lead	VBD
cord-263645-wupre5uj	55	25	to	to	IN
cord-263645-wupre5uj	55	26	a	a	DT
cord-263645-wupre5uj	55	27	statistically	statistically	RB
cord-263645-wupre5uj	55	28	significant	significant	JJ
cord-263645-wupre5uj	55	29	reduction	reduction	NN
cord-263645-wupre5uj	55	30	in	in	IN
cord-263645-wupre5uj	55	31	tumor	tumor	NN
cord-263645-wupre5uj	55	32	size	size	NN
cord-263645-wupre5uj	55	33	and	and	CC
cord-263645-wupre5uj	55	34	to	to	IN
cord-263645-wupre5uj	55	35	changes	change	NNS
cord-263645-wupre5uj	55	36	in	in	IN
cord-263645-wupre5uj	55	37	RNA	RNA	NNP
cord-263645-wupre5uj	55	38	and	and	CC
cord-263645-wupre5uj	55	39	protein	protein	NN
cord-263645-wupre5uj	55	40	levels	level	NNS
cord-263645-wupre5uj	55	41	consistent	consistent	JJ
cord-263645-wupre5uj	55	42	with	with	IN
cord-263645-wupre5uj	55	43	the	the	DT
cord-263645-wupre5uj	55	44	proposed	propose	VBN
cord-263645-wupre5uj	55	45	mode	mode	NN
cord-263645-wupre5uj	55	46	of	of	IN
cord-263645-wupre5uj	55	47	action	action	NN
cord-263645-wupre5uj	55	48	(	(	-LRB-
cord-263645-wupre5uj	55	49	17	17	CD
cord-263645-wupre5uj	55	50	)	)	-RRB-
cord-263645-wupre5uj	55	51	.	.	.
cord-263645-wupre5uj	56	1	Notably	notably	RB
cord-263645-wupre5uj	56	2	,	,	,
cord-263645-wupre5uj	56	3	examination	examination	NN
cord-263645-wupre5uj	56	4	of	of	IN
cord-263645-wupre5uj	56	5	this	this	DT
cord-263645-wupre5uj	56	6	list	list	NN
cord-263645-wupre5uj	56	7	further	further	RB
cord-263645-wupre5uj	56	8	exposes	expose	VBZ
cord-263645-wupre5uj	56	9	the	the	DT
cord-263645-wupre5uj	56	10	RNA	RNA	NNP
cord-263645-wupre5uj	56	11	-	-	HYPH
cord-263645-wupre5uj	56	12	driven	drive	VBN
cord-263645-wupre5uj	56	13	processes	process	NNS
cord-263645-wupre5uj	56	14	and	and	CC
cord-263645-wupre5uj	56	15	diseases	disease	NNS
cord-263645-wupre5uj	56	16	that	that	WDT
cord-263645-wupre5uj	56	17	still	still	RB
cord-263645-wupre5uj	56	18	lack	lack	VBP
cord-263645-wupre5uj	56	19	functional	functional	JJ
cord-263645-wupre5uj	56	20	chemical	chemical	NN
cord-263645-wupre5uj	56	21	probes	probe	NNS
cord-263645-wupre5uj	56	22	.	.	.
cord-263645-wupre5uj	57	1	Ideal	Ideal	NNP
cord-263645-wupre5uj	57	2	RNA	RNA	NNP
cord-263645-wupre5uj	57	3	targets	target	NNS
cord-263645-wupre5uj	57	4	have	have	VBP
cord-263645-wupre5uj	57	5	defined	define	VBN
cord-263645-wupre5uj	57	6	functional	functional	JJ
cord-263645-wupre5uj	57	7	sites	site	NNS
cord-263645-wupre5uj	57	8	and/or	and/or	CC
cord-263645-wupre5uj	57	9	clear	clear	JJ
cord-263645-wupre5uj	57	10	phenotypes	phenotype	NNS
cord-263645-wupre5uj	57	11	while	while	IN
cord-263645-wupre5uj	57	12	also	also	RB
cord-263645-wupre5uj	57	13	being	be	VBG
cord-263645-wupre5uj	57	14	of	of	IN
cord-263645-wupre5uj	57	15	high	high	JJ
cord-263645-wupre5uj	57	16	abundance	abundance	NN
cord-263645-wupre5uj	57	17	,	,	,
cord-263645-wupre5uj	57	18	and	and	CC
cord-263645-wupre5uj	57	19	several	several	JJ
cord-263645-wupre5uj	57	20	untargeted	untargeted	JJ
cord-263645-wupre5uj	57	21	RNAs	rna	NNS
cord-263645-wupre5uj	57	22	,	,	,
cord-263645-wupre5uj	57	23	ranging	range	VBG
cord-263645-wupre5uj	57	24	from	from	IN
cord-263645-wupre5uj	57	25	archaeal	archaeal	JJ
cord-263645-wupre5uj	57	26	ncRNA	ncRNA	NNS
cord-263645-wupre5uj	57	27	to	to	IN
cord-263645-wupre5uj	57	28	oncogenic	oncogenic	JJ
cord-263645-wupre5uj	57	29	lncR	lncR	NNPS
cord-263645-wupre5uj	57	30	-	-	HYPH
cord-263645-wupre5uj	57	31	NAs	NAs	NNPS
cord-263645-wupre5uj	57	32	,	,	,
cord-263645-wupre5uj	57	33	meet	meet	VB
cord-263645-wupre5uj	57	34	these	these	DT
cord-263645-wupre5uj	57	35	criteria	criterion	NNS
cord-263645-wupre5uj	57	36	.	.	.
cord-263645-wupre5uj	58	1	Many	many	JJ
cord-263645-wupre5uj	58	2	of	of	IN
cord-263645-wupre5uj	58	3	the	the	DT
cord-263645-wupre5uj	58	4	monovalent	monovalent	JJ
cord-263645-wupre5uj	58	5	ligands	ligand	NNS
cord-263645-wupre5uj	58	6	were	be	VBD
cord-263645-wupre5uj	58	7	discovered	discover	VBN
cord-263645-wupre5uj	58	8	through	through	IN
cord-263645-wupre5uj	58	9	traditional	traditional	JJ
cord-263645-wupre5uj	58	10	screening	screening	NN
cord-263645-wupre5uj	58	11	methods	method	NNS
cord-263645-wupre5uj	58	12	.	.	.
cord-263645-wupre5uj	59	1	Approximately	approximately	RB
cord-263645-wupre5uj	59	2	one	one	CD
cord-263645-wupre5uj	59	3	-	-	HYPH
cord-263645-wupre5uj	59	4	third	third	NN
cord-263645-wupre5uj	59	5	of	of	IN
cord-263645-wupre5uj	59	6	the	the	DT
cord-263645-wupre5uj	59	7	RNA	RNA	NNP
cord-263645-wupre5uj	60	1	:	:	:
cord-263645-wupre5uj	60	2	ligand	ligand	NN
cord-263645-wupre5uj	60	3	interactions	interaction	NNS
cord-263645-wupre5uj	60	4	were	be	VBD
cord-263645-wupre5uj	60	5	identified	identify	VBN
cord-263645-wupre5uj	60	6	by	by	IN
cord-263645-wupre5uj	60	7	each	each	DT
cord-263645-wupre5uj	60	8	of	of	IN
cord-263645-wupre5uj	60	9	the	the	DT
cord-263645-wupre5uj	60	10	following	follow	VBG
cord-263645-wupre5uj	60	11	approaches	approach	NNS
cord-263645-wupre5uj	60	12	:	:	:
cord-263645-wupre5uj	60	13	focused	focus	VBN
cord-263645-wupre5uj	60	14	-	-	HYPH
cord-263645-wupre5uj	60	15	screening	screening	NN
cord-263645-wupre5uj	60	16	(	(	-LRB-
cord-263645-wupre5uj	60	17	FcS	fcs	NN
cord-263645-wupre5uj	60	18	)	)	-RRB-
cord-263645-wupre5uj	60	19	,	,	,
cord-263645-wupre5uj	60	20	highthroughput	highthroughput	NN
cord-263645-wupre5uj	60	21	screening	screening	NN
cord-263645-wupre5uj	60	22	(	(	-LRB-
cord-263645-wupre5uj	60	23	HTS	HTS	NNP
cord-263645-wupre5uj	60	24	)	)	-RRB-
cord-263645-wupre5uj	60	25	,	,	,
cord-263645-wupre5uj	60	26	and	and	CC
cord-263645-wupre5uj	60	27	HTS	HTS	NNP
cord-263645-wupre5uj	60	28	followed	follow	VBD
cord-263645-wupre5uj	60	29	by	by	IN
cord-263645-wupre5uj	60	30	lead	lead	NN
cord-263645-wupre5uj	60	31	optimization	optimization	NN
cord-263645-wupre5uj	60	32	(	(	-LRB-
cord-263645-wupre5uj	60	33	HTS	HTS	NNP
cord-263645-wupre5uj	60	34	-	-	HYPH
cord-263645-wupre5uj	60	35	LO	LO	NNP
cord-263645-wupre5uj	60	36	)	)	-RRB-
cord-263645-wupre5uj	61	1	[	[	-LRB-
cord-263645-wupre5uj	61	2	Figure	figure	NN
cord-263645-wupre5uj	61	3	2A	2a	CD
cord-263645-wupre5uj	61	4	]	]	-RRB-
cord-263645-wupre5uj	61	5	.	.	.
cord-263645-wupre5uj	62	1	In	in	IN
cord-263645-wupre5uj	62	2	this	this	DT
cord-263645-wupre5uj	62	3	Survey	Survey	NNP
cord-263645-wupre5uj	62	4	,	,	,
cord-263645-wupre5uj	62	5	FcS	fcs	NN
cord-263645-wupre5uj	62	6	is	be	VBZ
cord-263645-wupre5uj	62	7	defined	define	VBN
cord-263645-wupre5uj	62	8	by	by	IN
cord-263645-wupre5uj	62	9	the	the	DT
cord-263645-wupre5uj	62	10	use	use	NN
cord-263645-wupre5uj	62	11	of	of	IN
cord-263645-wupre5uj	62	12	biased	biased	JJ
cord-263645-wupre5uj	62	13	libraries	library	NNS
cord-263645-wupre5uj	62	14	,	,	,
cord-263645-wupre5uj	62	15	which	which	WDT
cord-263645-wupre5uj	62	16	are	be	VBP
cord-263645-wupre5uj	62	17	typically	typically	RB
cord-263645-wupre5uj	62	18	based	base	VBN
cord-263645-wupre5uj	62	19	on	on	IN
cord-263645-wupre5uj	62	20	prior	prior	JJ
cord-263645-wupre5uj	62	21	knowledge	knowledge	NN
cord-263645-wupre5uj	62	22	of	of	IN
cord-263645-wupre5uj	62	23	a	a	DT
cord-263645-wupre5uj	62	24	particular	particular	JJ
cord-263645-wupre5uj	62	25	chemotype	chemotype	NN
cord-263645-wupre5uj	62	26	binding	binding	NN
cord-263645-wupre5uj	62	27	to	to	IN
cord-263645-wupre5uj	62	28	an	an	DT
cord-263645-wupre5uj	62	29	RNA	RNA	NNP
cord-263645-wupre5uj	62	30	element	element	NN
cord-263645-wupre5uj	62	31	.	.	.
cord-263645-wupre5uj	63	1	In	in	IN
cord-263645-wupre5uj	63	2	contrast	contrast	NN
cord-263645-wupre5uj	63	3	to	to	IN
cord-263645-wupre5uj	63	4	FcS	fcs	NN
cord-263645-wupre5uj	63	5	libraries	library	NNS
cord-263645-wupre5uj	63	6	,	,	,
cord-263645-wupre5uj	63	7	molecules	molecule	NNS
cord-263645-wupre5uj	63	8	specifically	specifically	RB
cord-263645-wupre5uj	63	9	designed	design	VBN
cord-263645-wupre5uj	63	10	to	to	TO
cord-263645-wupre5uj	63	11	explore	explore	VB
cord-263645-wupre5uj	63	12	structureactivity	structureactivity	NN
cord-263645-wupre5uj	63	13	relationships	relationship	NNS
cord-263645-wupre5uj	63	14	were	be	VBD
cord-263645-wupre5uj	63	15	classified	classify	VBN
cord-263645-wupre5uj	63	16	as	as	IN
cord-263645-wupre5uj	63	17	lead	lead	NN
cord-263645-wupre5uj	63	18	optimization	optimization	NN
cord-263645-wupre5uj	63	19	(	(	-LRB-
cord-263645-wupre5uj	63	20	LO	LO	NNP
cord-263645-wupre5uj	63	21	)	)	-RRB-
cord-263645-wupre5uj	63	22	.	.	.
cord-263645-wupre5uj	64	1	The	the	DT
cord-263645-wupre5uj	64	2	starting	start	VBG
cord-263645-wupre5uj	64	3	points	point	NNS
cord-263645-wupre5uj	64	4	for	for	IN
cord-263645-wupre5uj	64	5	several	several	JJ
cord-263645-wupre5uj	64	6	of	of	IN
cord-263645-wupre5uj	64	7	the	the	DT
cord-263645-wupre5uj	64	8	FcS	fcs	NN
cord-263645-wupre5uj	64	9	libraries	library	NNS
cord-263645-wupre5uj	64	10	and/or	and/or	CC
cord-263645-wupre5uj	64	11	other	other	JJ
cord-263645-wupre5uj	64	12	small	small	JJ
cord-263645-wupre5uj	64	13	molecule	molecule	NN
cord-263645-wupre5uj	64	14	identification	identification	NN
cord-263645-wupre5uj	64	15	strategies	strategy	NNS
cord-263645-wupre5uj	64	16	included	include	VBD
cord-263645-wupre5uj	64	17	RNA	RNA	NNP
cord-263645-wupre5uj	64	18	-	-	HYPH
cord-263645-wupre5uj	64	19	binding	bind	VBG
cord-263645-wupre5uj	64	20	natural	natural	JJ
cord-263645-wupre5uj	64	21	products	product	NNS
cord-263645-wupre5uj	64	22	,	,	,
cord-263645-wupre5uj	64	23	chemical	chemical	NN
cord-263645-wupre5uj	64	24	similarity	similarity	NN
cord-263645-wupre5uj	64	25	searching	search	VBG
cord-263645-wupre5uj	64	26	,	,	,
cord-263645-wupre5uj	64	27	and	and	CC
cord-263645-wupre5uj	64	28	scaffold	scaffold	NN
cord-263645-wupre5uj	64	29	-	-	HYPH
cord-263645-wupre5uj	64	30	based	base	VBN
cord-263645-wupre5uj	64	31	synthesis	synthesis	NN
cord-263645-wupre5uj	64	32	[	[	-LRB-
cord-263645-wupre5uj	64	33	Figure	figure	NN
cord-263645-wupre5uj	64	34	2B	2b	CD
cord-263645-wupre5uj	64	35	-D	-d	ADD
cord-263645-wupre5uj	64	36	]	]	-RRB-
cord-263645-wupre5uj	64	37	.	.	.
cord-263645-wupre5uj	65	1	We	-PRON-	PRP
cord-263645-wupre5uj	65	2	caution	caution	VBP
cord-263645-wupre5uj	65	3	that	that	IN
cord-263645-wupre5uj	65	4	the	the	DT
cord-263645-wupre5uj	65	5	relative	relative	JJ
cord-263645-wupre5uj	65	6	success	success	NN
cord-263645-wupre5uj	65	7	of	of	IN
cord-263645-wupre5uj	65	8	these	these	DT
cord-263645-wupre5uj	65	9	various	various	JJ
cord-263645-wupre5uj	65	10	approaches	approach	NNS
cord-263645-wupre5uj	65	11	can	can	MD
cord-263645-wupre5uj	65	12	not	not	RB
cord-263645-wupre5uj	65	13	be	be	VB
cord-263645-wupre5uj	65	14	evaluated	evaluate	VBN
cord-263645-wupre5uj	65	15	since	since	IN
cord-263645-wupre5uj	65	16	failed	fail	VBN
cord-263645-wupre5uj	65	17	attempts	attempt	NNS
cord-263645-wupre5uj	65	18	are	be	VBP
cord-263645-wupre5uj	65	19	not	not	RB
cord-263645-wupre5uj	65	20	typically	typically	RB
cord-263645-wupre5uj	65	21	documented	document	VBN
cord-263645-wupre5uj	65	22	in	in	IN
cord-263645-wupre5uj	65	23	the	the	DT
cord-263645-wupre5uj	65	24	literature	literature	NN
cord-263645-wupre5uj	65	25	.	.	.
cord-263645-wupre5uj	66	1	Hit	hit	NN
cord-263645-wupre5uj	66	2	rates	rate	NNS
cord-263645-wupre5uj	66	3	are	be	VBP
cord-263645-wupre5uj	66	4	one	one	CD
cord-263645-wupre5uj	66	5	of	of	IN
cord-263645-wupre5uj	66	6	the	the	DT
cord-263645-wupre5uj	66	7	benchmarks	benchmark	NNS
cord-263645-wupre5uj	66	8	used	use	VBD
cord-263645-wupre5uj	66	9	to	to	TO
cord-263645-wupre5uj	66	10	assess	assess	VB
cord-263645-wupre5uj	66	11	the	the	DT
cord-263645-wupre5uj	66	12	efficiency	efficiency	NN
cord-263645-wupre5uj	66	13	of	of	IN
cord-263645-wupre5uj	66	14	a	a	DT
cord-263645-wupre5uj	66	15	screen	screen	NN
cord-263645-wupre5uj	66	16	.	.	.
cord-263645-wupre5uj	67	1	We	-PRON-	PRP
cord-263645-wupre5uj	67	2	note	note	VBP
cord-263645-wupre5uj	67	3	prior	prior	RB
cord-263645-wupre5uj	67	4	to	to	IN
cord-263645-wupre5uj	67	5	the	the	DT
cord-263645-wupre5uj	67	6	discussion	discussion	NN
cord-263645-wupre5uj	67	7	that	that	WDT
cord-263645-wupre5uj	67	8	comparisons	comparison	VBZ
cord-263645-wupre5uj	67	9	across	across	IN
cord-263645-wupre5uj	67	10	studies	study	NNS
cord-263645-wupre5uj	67	11	should	should	MD
cord-263645-wupre5uj	67	12	be	be	VB
cord-263645-wupre5uj	67	13	interpreted	interpret	VBN
cord-263645-wupre5uj	67	14	with	with	IN
cord-263645-wupre5uj	67	15	caution	caution	NN
cord-263645-wupre5uj	67	16	as	as	IN
cord-263645-wupre5uj	67	17	the	the	DT
cord-263645-wupre5uj	67	18	definition	definition	NN
cord-263645-wupre5uj	67	19	of	of	IN
cord-263645-wupre5uj	67	20	a	a	DT
cord-263645-wupre5uj	67	21	small	small	JJ
cord-263645-wupre5uj	67	22	molecule	molecule	NN
cord-263645-wupre5uj	67	23	lead	lead	NN
cord-263645-wupre5uj	67	24	,	,	,
cord-263645-wupre5uj	67	25	the	the	DT
cord-263645-wupre5uj	67	26	specific	specific	JJ
cord-263645-wupre5uj	67	27	assays	assay	NNS
cord-263645-wupre5uj	67	28	used	use	VBN
cord-263645-wupre5uj	67	29	in	in	IN
cord-263645-wupre5uj	67	30	primary	primary	JJ
cord-263645-wupre5uj	67	31	screens	screen	NNS
cord-263645-wupre5uj	67	32	,	,	,
cord-263645-wupre5uj	67	33	the	the	DT
cord-263645-wupre5uj	67	34	controls	control	NNS
cord-263645-wupre5uj	67	35	utilized	utilize	VBN
cord-263645-wupre5uj	67	36	in	in	IN
cord-263645-wupre5uj	67	37	the	the	DT
cord-263645-wupre5uj	67	38	assay	assay	NN
cord-263645-wupre5uj	67	39	,	,	,
cord-263645-wupre5uj	67	40	and	and	CC
cord-263645-wupre5uj	67	41	the	the	DT
cord-263645-wupre5uj	67	42	number	number	NN
cord-263645-wupre5uj	67	43	of	of	IN
cord-263645-wupre5uj	67	44	false	false	JJ
cord-263645-wupre5uj	67	45	-	-	HYPH
cord-263645-wupre5uj	67	46	positives	positive	NNS
cord-263645-wupre5uj	67	47	and	and	CC
cord-263645-wupre5uj	67	48	-negatives	-negative	NNS
cord-263645-wupre5uj	67	49	can	can	MD
cord-263645-wupre5uj	67	50	be	be	VB
cord-263645-wupre5uj	67	51	highly	highly	RB
cord-263645-wupre5uj	67	52	variable	variable	JJ
cord-263645-wupre5uj	67	53	and	and	CC
cord-263645-wupre5uj	67	54	are	be	VBP
cord-263645-wupre5uj	67	55	not	not	RB
cord-263645-wupre5uj	67	56	always	always	RB
cord-263645-wupre5uj	67	57	reported	report	VBN
cord-263645-wupre5uj	67	58	.	.	.
cord-263645-wupre5uj	68	1	Of	of	IN
cord-263645-wupre5uj	68	2	the	the	DT
cord-263645-wupre5uj	68	3	41	41	CD
cord-263645-wupre5uj	68	4	RNA	RNA	NNP
cord-263645-wupre5uj	68	5	:	:	:
cord-263645-wupre5uj	68	6	small	small	JJ
cord-263645-wupre5uj	68	7	molecule	molecule	NN
cord-263645-wupre5uj	68	8	interactions	interaction	NNS
cord-263645-wupre5uj	68	9	discovered	discover	VBN
cord-263645-wupre5uj	68	10	through	through	IN
cord-263645-wupre5uj	68	11	HTS	HTS	NNP
cord-263645-wupre5uj	68	12	and	and	CC
cord-263645-wupre5uj	68	13	FcS	fcs	NN
cord-263645-wupre5uj	68	14	,	,	,
cord-263645-wupre5uj	68	15	20	20	CD
cord-263645-wupre5uj	68	16	had	have	VBD
cord-263645-wupre5uj	68	17	reported	report	VBN
cord-263645-wupre5uj	68	18	hit	hit	VBN
cord-263645-wupre5uj	68	19	rates	rate	NNS
cord-263645-wupre5uj	68	20	,	,	,
cord-263645-wupre5uj	68	21	which	which	WDT
cord-263645-wupre5uj	68	22	were	be	VBD
cord-263645-wupre5uj	68	23	compared	compare	VBN
cord-263645-wupre5uj	68	24	by	by	IN
cord-263645-wupre5uj	68	25	screening	screen	VBG
cord-263645-wupre5uj	68	26	approach	approach	NN
cord-263645-wupre5uj	68	27	,	,	,
cord-263645-wupre5uj	68	28	primary	primary	JJ
cord-263645-wupre5uj	68	29	screen	screen	NN
cord-263645-wupre5uj	68	30	,	,	,
cord-263645-wupre5uj	68	31	and	and	CC
cord-263645-wupre5uj	68	32	primary	primary	JJ
cord-263645-wupre5uj	68	33	library	library	NN
cord-263645-wupre5uj	69	1	[	[	-LRB-
cord-263645-wupre5uj	69	2	Figure	figure	NN
cord-263645-wupre5uj	69	3	3	3	CD
cord-263645-wupre5uj	69	4	]	]	-RRB-
cord-263645-wupre5uj	69	5	.	.	.
cord-263645-wupre5uj	70	1	The	the	DT
cord-263645-wupre5uj	70	2	higher	high	JJR
cord-263645-wupre5uj	70	3	hit	hit	NN
cord-263645-wupre5uj	70	4	rates	rate	NNS
cord-263645-wupre5uj	70	5	found	find	VBN
cord-263645-wupre5uj	70	6	in	in	IN
cord-263645-wupre5uj	70	7	some	some	DT
cord-263645-wupre5uj	70	8	FcS	fcs	NN
cord-263645-wupre5uj	70	9	approaches	approach	NNS
cord-263645-wupre5uj	70	10	provide	provide	VBP
cord-263645-wupre5uj	70	11	compelling	compelling	JJ
cord-263645-wupre5uj	70	12	evidence	evidence	NN
cord-263645-wupre5uj	70	13	that	that	IN
cord-263645-wupre5uj	70	14	FcS	fcs	NN
cord-263645-wupre5uj	70	15	is	be	VBZ
cord-263645-wupre5uj	70	16	efficient	efficient	JJ
cord-263645-wupre5uj	70	17	for	for	IN
cord-263645-wupre5uj	70	18	RNA	RNA	NNP
cord-263645-wupre5uj	70	19	targets	target	NNS
cord-263645-wupre5uj	70	20	,	,	,
cord-263645-wupre5uj	70	21	as	as	IN
cord-263645-wupre5uj	70	22	it	-PRON-	PRP
cord-263645-wupre5uj	70	23	is	be	VBZ
cord-263645-wupre5uj	70	24	known	know	VBN
cord-263645-wupre5uj	70	25	to	to	TO
cord-263645-wupre5uj	70	26	be	be	VB
cord-263645-wupre5uj	70	27	for	for	IN
cord-263645-wupre5uj	70	28	protein	protein	NN
cord-263645-wupre5uj	70	29	targets	target	NNS
cord-263645-wupre5uj	70	30	(	(	-LRB-
cord-263645-wupre5uj	70	31	35	35	CD
cord-263645-wupre5uj	70	32	,	,	,
cord-263645-wupre5uj	70	33	36	36	CD
cord-263645-wupre5uj	70	34	)	)	-RRB-
cord-263645-wupre5uj	70	35	.	.	.
cord-263645-wupre5uj	71	1	Moving	move	VBG
cord-263645-wupre5uj	71	2	forward	forward	RB
cord-263645-wupre5uj	71	3	,	,	,
cord-263645-wupre5uj	71	4	characterization	characterization	NN
cord-263645-wupre5uj	71	5	of	of	IN
cord-263645-wupre5uj	71	6	additional	additional	JJ
cord-263645-wupre5uj	71	7	RNA	RNA	NNP
cord-263645-wupre5uj	71	8	tertiary	tertiary	JJ
cord-263645-wupre5uj	71	9	structures	structure	NNS
cord-263645-wupre5uj	71	10	(	(	-LRB-
cord-263645-wupre5uj	71	11	8	8	CD
cord-263645-wupre5uj	71	12	,	,	,
cord-263645-wupre5uj	71	13	9	9	CD
cord-263645-wupre5uj	71	14	,	,	,
cord-263645-wupre5uj	71	15	37	37	CD
cord-263645-wupre5uj	71	16	,	,	,
cord-263645-wupre5uj	71	17	38	38	CD
cord-263645-wupre5uj	71	18	)	)	-RRB-
cord-263645-wupre5uj	71	19	and	and	CC
cord-263645-wupre5uj	71	20	the	the	DT
cord-263645-wupre5uj	71	21	identification	identification	NN
cord-263645-wupre5uj	71	22	of	of	IN
cord-263645-wupre5uj	71	23	novel	novel	NN
cord-263645-wupre5uj	71	24	RNA	rna	NN
cord-263645-wupre5uj	71	25	-	-	HYPH
cord-263645-wupre5uj	71	26	binding	bind	VBG
cord-263645-wupre5uj	71	27	chemotypes	chemotype	NNS
cord-263645-wupre5uj	71	28	(	(	-LRB-
cord-263645-wupre5uj	71	29	8	8	CD
cord-263645-wupre5uj	71	30	,	,	,
cord-263645-wupre5uj	71	31	39	39	CD
cord-263645-wupre5uj	71	32	,	,	,
cord-263645-wupre5uj	71	33	40	40	CD
cord-263645-wupre5uj	71	34	)	)	-RRB-
cord-263645-wupre5uj	71	35	will	will	MD
cord-263645-wupre5uj	71	36	expedite	expedite	VB
cord-263645-wupre5uj	71	37	the	the	DT
cord-263645-wupre5uj	71	38	FcS	fcs	NN
cord-263645-wupre5uj	71	39	approach	approach	NN
cord-263645-wupre5uj	71	40	for	for	IN
cord-263645-wupre5uj	71	41	discovering	discover	VBG
cord-263645-wupre5uj	71	42	biologically	biologically	RB
cord-263645-wupre5uj	71	43	active	active	JJ
cord-263645-wupre5uj	71	44	RNA	rna	NN
cord-263645-wupre5uj	71	45	-	-	HYPH
cord-263645-wupre5uj	71	46	targeted	target	VBN
cord-263645-wupre5uj	71	47	ligands	ligand	NNS
cord-263645-wupre5uj	71	48	.	.	.
cord-263645-wupre5uj	72	1	While	while	IN
cord-263645-wupre5uj	72	2	hit	hit	VBN
cord-263645-wupre5uj	72	3	rates	rate	NNS
cord-263645-wupre5uj	72	4	varied	vary	VBN
cord-263645-wupre5uj	72	5	widely	widely	RB
cord-263645-wupre5uj	72	6	within	within	IN
cord-263645-wupre5uj	72	7	each	each	DT
cord-263645-wupre5uj	72	8	type	type	NN
cord-263645-wupre5uj	72	9	of	of	IN
cord-263645-wupre5uj	72	10	primary	primary	JJ
cord-263645-wupre5uj	72	11	screen	screen	NN
cord-263645-wupre5uj	72	12	and	and	CC
cord-263645-wupre5uj	72	13	primary	primary	JJ
cord-263645-wupre5uj	72	14	library	library	NN
cord-263645-wupre5uj	72	15	,	,	,
cord-263645-wupre5uj	72	16	these	these	DT
cord-263645-wupre5uj	72	17	com	com	NN
cord-263645-wupre5uj	72	18	-	-	HYPH
cord-263645-wupre5uj	72	19	parisons	parison	NNS
cord-263645-wupre5uj	72	20	support	support	VBP
cord-263645-wupre5uj	72	21	the	the	DT
cord-263645-wupre5uj	72	22	potential	potential	NN
cord-263645-wupre5uj	72	23	of	of	IN
cord-263645-wupre5uj	72	24	many	many	JJ
cord-263645-wupre5uj	72	25	distinct	distinct	JJ
cord-263645-wupre5uj	72	26	paths	path	NNS
cord-263645-wupre5uj	72	27	toward	toward	IN
cord-263645-wupre5uj	72	28	RNA	RNA	NNP
cord-263645-wupre5uj	72	29	ligand	ligand	NN
cord-263645-wupre5uj	72	30	discovery	discovery	NN
cord-263645-wupre5uj	72	31	.	.	.
cord-263645-wupre5uj	73	1	Specific	specific	JJ
cord-263645-wupre5uj	73	2	aspects	aspect	NNS
cord-263645-wupre5uj	73	3	of	of	IN
cord-263645-wupre5uj	73	4	library	library	NN
cord-263645-wupre5uj	73	5	and	and	CC
cord-263645-wupre5uj	73	6	screen	screen	NN
cord-263645-wupre5uj	73	7	design	design	NN
cord-263645-wupre5uj	73	8	are	be	VBP
cord-263645-wupre5uj	73	9	discussed	discuss	VBN
cord-263645-wupre5uj	73	10	below	below	RB
cord-263645-wupre5uj	73	11	.	.	.
cord-263645-wupre5uj	74	1	Small	small	JJ
cord-263645-wupre5uj	74	2	molecules	molecule	NNS
cord-263645-wupre5uj	74	3	discovered	discover	VBN
cord-263645-wupre5uj	74	4	by	by	IN
cord-263645-wupre5uj	74	5	HTS	HTS	NNP
cord-263645-wupre5uj	74	6	were	be	VBD
cord-263645-wupre5uj	74	7	typically	typically	RB
cord-263645-wupre5uj	74	8	from	from	IN
cord-263645-wupre5uj	74	9	large	large	JJ
cord-263645-wupre5uj	74	10	libraries	library	NNS
cord-263645-wupre5uj	74	11	(	(	-LRB-
cord-263645-wupre5uj	74	12	n	n	NN
cord-263645-wupre5uj	74	13	>	>	XX
cord-263645-wupre5uj	74	14	50	50	CD
cord-263645-wupre5uj	74	15	000	000	CD
cord-263645-wupre5uj	74	16	small	small	JJ
cord-263645-wupre5uj	74	17	molecules	molecule	NNS
cord-263645-wupre5uj	74	18	)	)	-RRB-
cord-263645-wupre5uj	74	19	,	,	,
cord-263645-wupre5uj	74	20	including	include	VBG
cord-263645-wupre5uj	74	21	three	three	CD
cord-263645-wupre5uj	74	22	corporate	corporate	JJ
cord-263645-wupre5uj	74	23	libraries	library	NNS
cord-263645-wupre5uj	74	24	and	and	CC
cord-263645-wupre5uj	74	25	the	the	DT
cord-263645-wupre5uj	74	26	NIH	NIH	NNP
cord-263645-wupre5uj	74	27	Small	Small	NNP
cord-263645-wupre5uj	74	28	Molecule	Molecule	NNP
cord-263645-wupre5uj	74	29	Repository	repository	NN
cord-263645-wupre5uj	74	30	[	[	-LRB-
cord-263645-wupre5uj	74	31	Table	table	NN
cord-263645-wupre5uj	74	32	1	1	CD
cord-263645-wupre5uj	74	33	]	]	-RRB-
cord-263645-wupre5uj	74	34	.	.	.
cord-263645-wupre5uj	75	1	There	there	EX
cord-263645-wupre5uj	75	2	were	be	VBD
cord-263645-wupre5uj	75	3	select	select	JJ
cord-263645-wupre5uj	75	4	examples	example	NNS
cord-263645-wupre5uj	75	5	of	of	IN
cord-263645-wupre5uj	75	6	smaller	small	JJR
cord-263645-wupre5uj	75	7	libraries	library	NNS
cord-263645-wupre5uj	75	8	as	as	RB
cord-263645-wupre5uj	75	9	well	well	RB
cord-263645-wupre5uj	75	10	:	:	:
cord-263645-wupre5uj	75	11	FDA	FDA	NNP
cord-263645-wupre5uj	75	12	-	-	HYPH
cord-263645-wupre5uj	75	13	approved	approve	VBN
cord-263645-wupre5uj	75	14	drugs	drug	NNS
cord-263645-wupre5uj	75	15	(	(	-LRB-
cord-263645-wupre5uj	75	16	n	n	NN
cord-263645-wupre5uj	75	17	=	=	SYM
cord-263645-wupre5uj	75	18	1120	1120	CD
cord-263645-wupre5uj	75	19	)	)	-RRB-
cord-263645-wupre5uj	75	20	and	and	CC
cord-263645-wupre5uj	75	21	UCLA	UCLA	NNP
cord-263645-wupre5uj	75	22	academic	academic	JJ
cord-263645-wupre5uj	75	23	library	library	NN
cord-263645-wupre5uj	75	24	(	(	-LRB-
cord-263645-wupre5uj	76	1	n	n	NN
cord-263645-wupre5uj	76	2	=	=	SYM
cord-263645-wupre5uj	76	3	1692	1692	CD
cord-263645-wupre5uj	76	4	)	)	-RRB-
cord-263645-wupre5uj	76	5	.	.	.
cord-263645-wupre5uj	77	1	Importantly	importantly	RB
cord-263645-wupre5uj	77	2	,	,	,
cord-263645-wupre5uj	77	3	some	some	DT
cord-263645-wupre5uj	77	4	of	of	IN
cord-263645-wupre5uj	77	5	these	these	DT
cord-263645-wupre5uj	77	6	reports	report	NNS
cord-263645-wupre5uj	77	7	explicitly	explicitly	RB
cord-263645-wupre5uj	77	8	stated	state	VBD
cord-263645-wupre5uj	77	9	that	that	IN
cord-263645-wupre5uj	77	10	libraries	library	NNS
cord-263645-wupre5uj	77	11	were	be	VBD
cord-263645-wupre5uj	77	12	filtered	filter	VBN
cord-263645-wupre5uj	77	13	to	to	TO
cord-263645-wupre5uj	77	14	yield	yield	VB
cord-263645-wupre5uj	77	15	small	small	JJ
cord-263645-wupre5uj	77	16	molecules	molecule	NNS
cord-263645-wupre5uj	77	17	with	with	IN
cord-263645-wupre5uj	78	1	favorable	favorable	JJ
cord-263645-wupre5uj	78	2	medicinal	medicinal	JJ
cord-263645-wupre5uj	78	3	chemistry	chemistry	NN
cord-263645-wupre5uj	78	4	proper-	proper-	NN
cord-263645-wupre5uj	78	5	S	s	NN
cord-263645-wupre5uj	78	6	-	-	HYPH
cord-263645-wupre5uj	78	7	amino	amino	NN
cord-263645-wupre5uj	78	8	acid	acid	NN
cord-263645-wupre5uj	78	9	conjugates	conjugate	VBZ
cord-263645-wupre5uj	78	10	A	a	DT
cord-263645-wupre5uj	78	11	Screening	Screening	NNP
cord-263645-wupre5uj	78	12	Approaches	approach	VBZ
cord-263645-wupre5uj	78	13	ties	tie	NNS
cord-263645-wupre5uj	78	14	prior	prior	RB
cord-263645-wupre5uj	78	15	to	to	IN
cord-263645-wupre5uj	78	16	screening	screening	NN
cord-263645-wupre5uj	78	17	.	.	.
cord-263645-wupre5uj	79	1	While	while	IN
cord-263645-wupre5uj	79	2	successful	successful	JJ
cord-263645-wupre5uj	79	3	in	in	IN
cord-263645-wupre5uj	79	4	protein	protein	NN
cord-263645-wupre5uj	79	5	-	-	HYPH
cord-263645-wupre5uj	79	6	targeted	target	VBN
cord-263645-wupre5uj	79	7	drug	drug	NN
cord-263645-wupre5uj	79	8	discovery	discovery	NN
cord-263645-wupre5uj	79	9	(	(	-LRB-
cord-263645-wupre5uj	79	10	41	41	CD
cord-263645-wupre5uj	79	11	)	)	-RRB-
cord-263645-wupre5uj	79	12	,	,	,
cord-263645-wupre5uj	79	13	only	only	RB
cord-263645-wupre5uj	79	14	one	one	CD
cord-263645-wupre5uj	79	15	report	report	NN
cord-263645-wupre5uj	79	16	identified	identify	VBD
cord-263645-wupre5uj	79	17	a	a	DT
cord-263645-wupre5uj	79	18	bioactive	bioactive	JJ
cord-263645-wupre5uj	79	19	ligand	ligand	NN
cord-263645-wupre5uj	79	20	from	from	IN
cord-263645-wupre5uj	79	21	a	a	DT
cord-263645-wupre5uj	79	22	fragment	fragment	NN
cord-263645-wupre5uj	79	23	-	-	HYPH
cord-263645-wupre5uj	79	24	based	base	VBN
cord-263645-wupre5uj	79	25	library	library	NN
cord-263645-wupre5uj	79	26	(	(	-LRB-
cord-263645-wupre5uj	79	27	commercial	commercial	JJ
cord-263645-wupre5uj	79	28	library	library	NN
cord-263645-wupre5uj	79	29	)	)	-RRB-
cord-263645-wupre5uj	79	30	(	(	-LRB-
cord-263645-wupre5uj	79	31	42	42	CD
cord-263645-wupre5uj	79	32	)	)	-RRB-
cord-263645-wupre5uj	79	33	.	.	.
cord-263645-wupre5uj	80	1	Once	once	RB
cord-263645-wupre5uj	80	2	optimized	optimize	VBN
cord-263645-wupre5uj	80	3	,	,	,
cord-263645-wupre5uj	80	4	the	the	DT
cord-263645-wupre5uj	80	5	scaffold	scaffold	NN
cord-263645-wupre5uj	80	6	yielded	yield	VBD
cord-263645-wupre5uj	80	7	four	four	CD
cord-263645-wupre5uj	80	8	additional	additional	JJ
cord-263645-wupre5uj	80	9	molecules	molecule	NNS
cord-263645-wupre5uj	80	10	that	that	WDT
cord-263645-wupre5uj	80	11	targeted	target	VBD
cord-263645-wupre5uj	80	12	the	the	DT
cord-263645-wupre5uj	80	13	Influenza	Influenza	NNP
cord-263645-wupre5uj	80	14	A	A	NNP
cord-263645-wupre5uj	80	15	RNA	RNA	NNP
cord-263645-wupre5uj	80	16	promoter	promoter	NN
cord-263645-wupre5uj	80	17	with	with	IN
cord-263645-wupre5uj	80	18	IC	IC	NNP
cord-263645-wupre5uj	80	19	50	50	CD
cord-263645-wupre5uj	80	20	values	value	NNS
cord-263645-wupre5uj	80	21	ranging	range	VBG
cord-263645-wupre5uj	80	22	from	from	IN
cord-263645-wupre5uj	80	23	34	34	CD
cord-263645-wupre5uj	80	24	to	to	TO
cord-263645-wupre5uj	80	25	44	44	CD
cord-263645-wupre5uj	80	26	M	M	NNS
cord-263645-wupre5uj	80	27	in	in	IN
cord-263645-wupre5uj	80	28	a	a	DT
cord-263645-wupre5uj	80	29	cell	cell	NN
cord-263645-wupre5uj	80	30	-	-	HYPH
cord-263645-wupre5uj	80	31	based	base	VBN
cord-263645-wupre5uj	80	32	luciferase	luciferase	NN
cord-263645-wupre5uj	80	33	assay	assay	NN
cord-263645-wupre5uj	80	34	(	(	-LRB-
cord-263645-wupre5uj	80	35	43	43	CD
cord-263645-wupre5uj	80	36	)	)	-RRB-
cord-263645-wupre5uj	80	37	.	.	.
cord-263645-wupre5uj	81	1	Similarly	similarly	RB
cord-263645-wupre5uj	81	2	,	,	,
cord-263645-wupre5uj	81	3	only	only	RB
cord-263645-wupre5uj	81	4	two	two	CD
cord-263645-wupre5uj	81	5	reports	report	NNS
cord-263645-wupre5uj	81	6	yielded	yield	VBD
cord-263645-wupre5uj	81	7	bioactive	bioactive	JJ
cord-263645-wupre5uj	81	8	small	small	JJ
cord-263645-wupre5uj	81	9	molecules	molecule	NNS
cord-263645-wupre5uj	81	10	from	from	IN
cord-263645-wupre5uj	81	11	natural	natural	JJ
cord-263645-wupre5uj	81	12	productbased	productbased	JJ
cord-263645-wupre5uj	81	13	libraries	library	NNS
cord-263645-wupre5uj	81	14	(	(	-LRB-
cord-263645-wupre5uj	81	15	synthetic	synthetic	JJ
cord-263645-wupre5uj	81	16	library	library	NN
cord-263645-wupre5uj	81	17	and	and	CC
cord-263645-wupre5uj	81	18	academic	academic	JJ
cord-263645-wupre5uj	81	19	library	library	NN
cord-263645-wupre5uj	81	20	)	)	-RRB-
cord-263645-wupre5uj	81	21	(	(	-LRB-
cord-263645-wupre5uj	81	22	19	19	CD
cord-263645-wupre5uj	81	23	,	,	,
cord-263645-wupre5uj	81	24	44	44	CD
cord-263645-wupre5uj	81	25	)	)	-RRB-
cord-263645-wupre5uj	81	26	.	.	.
cord-263645-wupre5uj	82	1	Both	both	DT
cord-263645-wupre5uj	82	2	of	of	IN
cord-263645-wupre5uj	82	3	these	these	DT
cord-263645-wupre5uj	82	4	screens	screen	NNS
cord-263645-wupre5uj	82	5	contained	contain	VBD
cord-263645-wupre5uj	82	6	fewer	few	JJR
cord-263645-wupre5uj	82	7	than	than	IN
cord-263645-wupre5uj	82	8	150	150	CD
cord-263645-wupre5uj	82	9	small	small	JJ
cord-263645-wupre5uj	82	10	molecules	molecule	NNS
cord-263645-wupre5uj	82	11	,	,	,
cord-263645-wupre5uj	82	12	yet	yet	CC
cord-263645-wupre5uj	82	13	identified	identify	VBN
cord-263645-wupre5uj	82	14	ligands	ligand	NNS
cord-263645-wupre5uj	82	15	that	that	WDT
cord-263645-wupre5uj	82	16	bind	bind	VBP
cord-263645-wupre5uj	82	17	and	and	CC
cord-263645-wupre5uj	82	18	modulate	modulate	VB
cord-263645-wupre5uj	82	19	G	g	NN
cord-263645-wupre5uj	82	20	-	-	HYPH
cord-263645-wupre5uj	82	21	quadruplex	quadruplex	NN
cord-263645-wupre5uj	82	22	structures	structure	NNS
cord-263645-wupre5uj	82	23	located	locate	VBN
cord-263645-wupre5uj	82	24	in	in	IN
cord-263645-wupre5uj	82	25	the	the	DT
cord-263645-wupre5uj	82	26	5	5	CD
cord-263645-wupre5uj	82	27	-UTR	-utr	NN
cord-263645-wupre5uj	82	28	of	of	IN
cord-263645-wupre5uj	82	29	two	two	CD
cord-263645-wupre5uj	82	30	distinct	distinct	JJ
cord-263645-wupre5uj	82	31	mRNAs	mRNAs	NNPS
cord-263645-wupre5uj	82	32	.	.	.
cord-263645-wupre5uj	83	1	It	-PRON-	PRP
cord-263645-wupre5uj	83	2	is	be	VBZ
cord-263645-wupre5uj	83	3	promising	promise	VBG
cord-263645-wupre5uj	83	4	that	that	IN
cord-263645-wupre5uj	83	5	small	small	JJ
cord-263645-wupre5uj	83	6	molecules	molecule	NNS
cord-263645-wupre5uj	83	7	were	be	VBD
cord-263645-wupre5uj	83	8	discovered	discover	VBN
cord-263645-wupre5uj	83	9	from	from	IN
cord-263645-wupre5uj	83	10	a	a	DT
cord-263645-wupre5uj	83	11	variety	variety	NN
cord-263645-wupre5uj	83	12	of	of	IN
cord-263645-wupre5uj	83	13	HTS	HTS	NNP
cord-263645-wupre5uj	83	14	libraries	library	NNS
cord-263645-wupre5uj	83	15	,	,	,
cord-263645-wupre5uj	83	16	suggesting	suggest	VBG
cord-263645-wupre5uj	83	17	that	that	IN
cord-263645-wupre5uj	83	18	biologically	biologically	RB
cord-263645-wupre5uj	83	19	active	active	JJ
cord-263645-wupre5uj	83	20	,	,	,
cord-263645-wupre5uj	83	21	RNA	rna	NN
cord-263645-wupre5uj	83	22	-	-	HYPH
cord-263645-wupre5uj	83	23	binding	bind	VBG
cord-263645-wupre5uj	83	24	ligands	ligand	NNS
cord-263645-wupre5uj	83	25	can	can	MD
cord-263645-wupre5uj	83	26	be	be	VB
cord-263645-wupre5uj	83	27	found	find	VBN
cord-263645-wupre5uj	83	28	in	in	IN
cord-263645-wupre5uj	83	29	a	a	DT
cord-263645-wupre5uj	83	30	subset	subset	NN
cord-263645-wupre5uj	83	31	of	of	IN
cord-263645-wupre5uj	83	32	current	current	JJ
cord-263645-wupre5uj	83	33	small	small	JJ
cord-263645-wupre5uj	83	34	molecule	molecule	NN
cord-263645-wupre5uj	83	35	chemical	chemical	NN
cord-263645-wupre5uj	83	36	space	space	NN
cord-263645-wupre5uj	83	37	(	(	-LRB-
cord-263645-wupre5uj	83	38	22	22	CD
cord-263645-wupre5uj	83	39	)	)	-RRB-
cord-263645-wupre5uj	83	40	.	.	.
cord-263645-wupre5uj	84	1	Further	further	JJ
cord-263645-wupre5uj	84	2	validation	validation	NN
cord-263645-wupre5uj	84	3	and	and	CC
cord-263645-wupre5uj	84	4	exploration	exploration	NN
cord-263645-wupre5uj	84	5	of	of	IN
cord-263645-wupre5uj	84	6	this	this	DT
cord-263645-wupre5uj	84	7	space	space	NN
cord-263645-wupre5uj	84	8	could	could	MD
cord-263645-wupre5uj	84	9	lead	lead	VB
cord-263645-wupre5uj	84	10	to	to	IN
cord-263645-wupre5uj	84	11	greater	great	JJR
cord-263645-wupre5uj	84	12	efficiency	efficiency	NN
cord-263645-wupre5uj	84	13	and	and	CC
cord-263645-wupre5uj	84	14	success	success	NN
cord-263645-wupre5uj	84	15	in	in	IN
cord-263645-wupre5uj	84	16	identifying	identify	VBG
cord-263645-wupre5uj	84	17	bioactive	bioactive	JJ
cord-263645-wupre5uj	84	18	leads	lead	NNS
cord-263645-wupre5uj	84	19	as	as	RB
cord-263645-wupre5uj	84	20	well	well	RB
cord-263645-wupre5uj	84	21	as	as	IN
cord-263645-wupre5uj	84	22	RNA	rna	NN
cord-263645-wupre5uj	84	23	-	-	HYPH
cord-263645-wupre5uj	84	24	privileged	privileged	JJ
cord-263645-wupre5uj	84	25	chemotypes	chemotype	NNS
cord-263645-wupre5uj	84	26	.	.	.
cord-263645-wupre5uj	85	1	As	as	IN
cord-263645-wupre5uj	85	2	expected	expect	VBN
cord-263645-wupre5uj	85	3	,	,	,
cord-263645-wupre5uj	85	4	FcS	fcs	NN
cord-263645-wupre5uj	85	5	used	use	VBD
cord-263645-wupre5uj	85	6	smaller	small	JJR
cord-263645-wupre5uj	85	7	libraries	library	NNS
cord-263645-wupre5uj	85	8	,	,	,
cord-263645-wupre5uj	85	9	typically	typically	RB
cord-263645-wupre5uj	85	10	containing	contain	VBG
cord-263645-wupre5uj	85	11	fewer	few	JJR
cord-263645-wupre5uj	85	12	than	than	IN
cord-263645-wupre5uj	85	13	150	150	CD
cord-263645-wupre5uj	85	14	small	small	JJ
cord-263645-wupre5uj	85	15	molecules	molecule	NNS
cord-263645-wupre5uj	85	16	[	[	-LRB-
cord-263645-wupre5uj	85	17	Table	table	NN
cord-263645-wupre5uj	85	18	1	1	CD
cord-263645-wupre5uj	85	19	]	]	-RRB-
cord-263645-wupre5uj	85	20	.	.	.
cord-263645-wupre5uj	86	1	The	the	DT
cord-263645-wupre5uj	86	2	largest	large	JJS
cord-263645-wupre5uj	86	3	FcS	fcs	NN
cord-263645-wupre5uj	86	4	library	library	NN
cord-263645-wupre5uj	86	5	(	(	-LRB-
cord-263645-wupre5uj	86	6	n	n	NN
cord-263645-wupre5uj	86	7	=	=	SYM
cord-263645-wupre5uj	86	8	320	320	CD
cord-263645-wupre5uj	86	9	,	,	,
cord-263645-wupre5uj	86	10	academic	academic	JJ
cord-263645-wupre5uj	86	11	library	library	NN
cord-263645-wupre5uj	86	12	)	)	-RRB-
cord-263645-wupre5uj	86	13	was	be	VBD
cord-263645-wupre5uj	86	14	designed	design	VBN
cord-263645-wupre5uj	86	15	through	through	IN
cord-263645-wupre5uj	86	16	a	a	DT
cord-263645-wupre5uj	86	17	chemical	chemical	NN
cord-263645-wupre5uj	86	18	similarity	similarity	NN
cord-263645-wupre5uj	86	19	search	search	NN
cord-263645-wupre5uj	86	20	of	of	IN
cord-263645-wupre5uj	86	21	the	the	DT
cord-263645-wupre5uj	86	22	bis	bis	NNP
cord-263645-wupre5uj	86	23	-	-	HYPH
cord-263645-wupre5uj	86	24	benzimidazole	benzimidazole	NNP
cord-263645-wupre5uj	86	25	and	and	CC
cord-263645-wupre5uj	86	26	similar	similar	JJ
cord-263645-wupre5uj	86	27	cores	core	NNS
cord-263645-wupre5uj	86	28	,	,	,
cord-263645-wupre5uj	86	29	which	which	WDT
cord-263645-wupre5uj	86	30	have	have	VBP
cord-263645-wupre5uj	86	31	shown	show	VBN
cord-263645-wupre5uj	86	32	preferences	preference	NNS
cord-263645-wupre5uj	86	33	for	for	IN
cord-263645-wupre5uj	86	34	1	1	CD
cord-263645-wupre5uj	86	35	×	×	NN
cord-263645-wupre5uj	86	36	1	1	CD
cord-263645-wupre5uj	86	37	nucleotide	nucleotide	JJ
cord-263645-wupre5uj	86	38	internal	internal	JJ
cord-263645-wupre5uj	86	39	loops	loop	NNS
cord-263645-wupre5uj	86	40	(	(	-LRB-
cord-263645-wupre5uj	86	41	45	45	CD
cord-263645-wupre5uj	86	42	)	)	-RRB-
cord-263645-wupre5uj	86	43	.	.	.
cord-263645-wupre5uj	87	1	In	in	IN
cord-263645-wupre5uj	87	2	addition	addition	NN
cord-263645-wupre5uj	87	3	,	,	,
cord-263645-wupre5uj	87	4	this	this	DT
cord-263645-wupre5uj	87	5	library	library	NN
cord-263645-wupre5uj	87	6	was	be	VBD
cord-263645-wupre5uj	87	7	filtered	filter	VBN
cord-263645-wupre5uj	87	8	for	for	IN
cord-263645-wupre5uj	87	9	favorable	favorable	JJ
cord-263645-wupre5uj	87	10	medicinal	medicinal	JJ
cord-263645-wupre5uj	87	11	chemistry	chemistry	NN
cord-263645-wupre5uj	87	12	properties	property	NNS
cord-263645-wupre5uj	87	13	,	,	,
cord-263645-wupre5uj	87	14	and	and	CC
cord-263645-wupre5uj	87	15	the	the	DT
cord-263645-wupre5uj	87	16	screen	screen	NN
cord-263645-wupre5uj	87	17	resulted	result	VBD
cord-263645-wupre5uj	87	18	in	in	IN
cord-263645-wupre5uj	87	19	three	three	CD
cord-263645-wupre5uj	87	20	leads	lead	NNS
cord-263645-wupre5uj	87	21	that	that	DT
cord-263645-wupre5uj	87	22	:	:	:
cord-263645-wupre5uj	87	23	(	(	-LRB-
cord-263645-wupre5uj	87	24	i	i	NN
cord-263645-wupre5uj	87	25	)	)	-RRB-
cord-263645-wupre5uj	87	26	bound	bind	VBN
cord-263645-wupre5uj	87	27	r(CUG	r(cug	CD
cord-263645-wupre5uj	87	28	)	)	-RRB-
cord-263645-wupre5uj	87	29	exp	exp	NN
cord-263645-wupre5uj	87	30	in	in	FW
cord-263645-wupre5uj	87	31	vitro	vitro	FW
cord-263645-wupre5uj	87	32	;	;	,
cord-263645-wupre5uj	87	33	(	(	-LRB-
cord-263645-wupre5uj	87	34	ii	ii	NN
cord-263645-wupre5uj	87	35	)	)	-RRB-
cord-263645-wupre5uj	87	36	led	lead	VBD
cord-263645-wupre5uj	87	37	to	to	IN
cord-263645-wupre5uj	87	38	a	a	DT
cord-263645-wupre5uj	87	39	statistically	statistically	RB
cord-263645-wupre5uj	87	40	significant	significant	JJ
cord-263645-wupre5uj	87	41	decrease	decrease	NN
cord-263645-wupre5uj	87	42	in	in	IN
cord-263645-wupre5uj	87	43	cTNT	ctnt	FW
cord-263645-wupre5uj	87	44	mini	mini	JJ
cord-263645-wupre5uj	87	45	-	-	NN
cord-263645-wupre5uj	87	46	gene	gene	NN
cord-263645-wupre5uj	87	47	exon	exon	NN
cord-263645-wupre5uj	87	48	inclusion	inclusion	NN
cord-263645-wupre5uj	87	49	in	in	IN
cord-263645-wupre5uj	87	50	cells	cell	NNS
cord-263645-wupre5uj	87	51	and	and	CC
cord-263645-wupre5uj	87	52	(	(	-LRB-
cord-263645-wupre5uj	87	53	iii	iii	NN
cord-263645-wupre5uj	87	54	)	)	-RRB-
cord-263645-wupre5uj	87	55	were	be	VBD
cord-263645-wupre5uj	87	56	selective	selective	JJ
cord-263645-wupre5uj	87	57	for	for	IN
cord-263645-wupre5uj	87	58	a	a	DT
cord-263645-wupre5uj	87	59	mini	mini	JJ
cord-263645-wupre5uj	87	60	-	-	NN
cord-263645-wupre5uj	87	61	gene	gene	NN
cord-263645-wupre5uj	87	62	with	with	IN
cord-263645-wupre5uj	87	63	960	960	CD
cord-263645-wupre5uj	87	64	r(CUG	r(cug	CD
cord-263645-wupre5uj	87	65	)	)	-RRB-
cord-263645-wupre5uj	87	66	repeats	repeat	VBZ
cord-263645-wupre5uj	87	67	compared	compare	VBN
cord-263645-wupre5uj	87	68	to	to	IN
cord-263645-wupre5uj	87	69	a	a	DT
cord-263645-wupre5uj	87	70	mini	mini	JJ
cord-263645-wupre5uj	87	71	-	-	NN
cord-263645-wupre5uj	87	72	gene	gene	NN
cord-263645-wupre5uj	87	73	without	without	IN
cord-263645-wupre5uj	87	74	the	the	DT
cord-263645-wupre5uj	87	75	repeats	repeat	NNS
cord-263645-wupre5uj	87	76	.	.	.
cord-263645-wupre5uj	88	1	FcS	FcS	NNP
cord-263645-wupre5uj	88	2	also	also	RB
cord-263645-wupre5uj	88	3	encompassed	encompass	VBD
cord-263645-wupre5uj	88	4	RNA	RNA	NNP
cord-263645-wupre5uj	88	5	structure	structure	NN
cord-263645-wupre5uj	88	6	-	-	HYPH
cord-263645-wupre5uj	88	7	guided	guide	VBN
cord-263645-wupre5uj	88	8	design	design	NN
cord-263645-wupre5uj	88	9	,	,	,
cord-263645-wupre5uj	88	10	which	which	WDT
cord-263645-wupre5uj	88	11	included	include	VBD
cord-263645-wupre5uj	88	12	two	two	CD
cord-263645-wupre5uj	88	13	studies	study	NNS
cord-263645-wupre5uj	88	14	utilizing	utilize	VBG
cord-263645-wupre5uj	88	15	molecular	molecular	JJ
cord-263645-wupre5uj	88	16	modeling	modeling	NN
cord-263645-wupre5uj	88	17	to	to	TO
cord-263645-wupre5uj	88	18	identify	identify	VB
cord-263645-wupre5uj	88	19	ligands	ligand	NNS
cord-263645-wupre5uj	88	20	structurally	structurally	RB
cord-263645-wupre5uj	88	21	similar	similar	JJ
cord-263645-wupre5uj	88	22	to	to	IN
cord-263645-wupre5uj	88	23	guanine	guanine	NN
cord-263645-wupre5uj	88	24	for	for	IN
cord-263645-wupre5uj	88	25	the	the	DT
cord-263645-wupre5uj	88	26	xpt	xpt	NNP
cord-263645-wupre5uj	88	27	-	-	HYPH
cord-263645-wupre5uj	88	28	pbuX	pbux	JJ
cord-263645-wupre5uj	88	29	riboswitch	riboswitch	NN
cord-263645-wupre5uj	88	30	(	(	-LRB-
cord-263645-wupre5uj	88	31	46	46	CD
cord-263645-wupre5uj	88	32	,	,	,
cord-263645-wupre5uj	88	33	47	47	CD
cord-263645-wupre5uj	88	34	)	)	-RRB-
cord-263645-wupre5uj	88	35	.	.	.
cord-263645-wupre5uj	89	1	In	in	IN
cord-263645-wupre5uj	89	2	another	another	DT
cord-263645-wupre5uj	89	3	structure	structure	NN
cord-263645-wupre5uj	89	4	-	-	HYPH
cord-263645-wupre5uj	89	5	guided	guide	VBN
cord-263645-wupre5uj	89	6	approach	approach	NN
cord-263645-wupre5uj	89	7	,	,	,
cord-263645-wupre5uj	89	8	a	a	DT
cord-263645-wupre5uj	89	9	small	small	JJ
cord-263645-wupre5uj	89	10	library	library	NN
cord-263645-wupre5uj	89	11	of	of	IN
cord-263645-wupre5uj	89	12	p	p	NN
cord-263645-wupre5uj	89	13	-	-	HYPH
cord-263645-wupre5uj	89	14	terphenylene	terphenylene	NN
cord-263645-wupre5uj	89	15	-	-	HYPH
cord-263645-wupre5uj	89	16	based	base	VBN
cord-263645-wupre5uj	89	17	ligands	ligand	NNS
cord-263645-wupre5uj	89	18	was	be	VBD
cord-263645-wupre5uj	89	19	designed	design	VBN
cord-263645-wupre5uj	89	20	to	to	TO
cord-263645-wupre5uj	89	21	mimic	mimic	VB
cord-263645-wupre5uj	89	22	an	an	DT
cord-263645-wupre5uj	89	23	␣	␣	NN
cord-263645-wupre5uj	89	24	-helix	-helix	NN
cord-263645-wupre5uj	89	25	of	of	IN
cord-263645-wupre5uj	89	26	Rev	Rev	NNP
cord-263645-wupre5uj	89	27	,	,	,
cord-263645-wupre5uj	89	28	a	a	DT
cord-263645-wupre5uj	89	29	protein	protein	NN
cord-263645-wupre5uj	89	30	-	-	HYPH
cord-263645-wupre5uj	89	31	binding	bind	VBG
cord-263645-wupre5uj	89	32	partner	partner	NN
cord-263645-wupre5uj	89	33	of	of	IN
cord-263645-wupre5uj	89	34	the	the	DT
cord-263645-wupre5uj	89	35	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	89	36	Rev	Rev	NNP
cord-263645-wupre5uj	89	37	Response	Response	NNP
cord-263645-wupre5uj	89	38	Element	Element	NNP
cord-263645-wupre5uj	89	39	(	(	-LRB-
cord-263645-wupre5uj	89	40	RRE	RRE	NNP
cord-263645-wupre5uj	89	41	)	)	-RRB-
cord-263645-wupre5uj	89	42	(	(	-LRB-
cord-263645-wupre5uj	89	43	48	48	CD
cord-263645-wupre5uj	89	44	)	)	-RRB-
cord-263645-wupre5uj	89	45	.	.	.
cord-263645-wupre5uj	90	1	Leads	lead	NNS
cord-263645-wupre5uj	90	2	were	be	VBD
cord-263645-wupre5uj	90	3	selected	select	VBN
cord-263645-wupre5uj	90	4	by	by	IN
cord-263645-wupre5uj	90	5	docking	docking	NN
cord-263645-wupre5uj	90	6	,	,	,
cord-263645-wupre5uj	90	7	with	with	IN
cord-263645-wupre5uj	90	8	one	one	CD
cord-263645-wupre5uj	90	9	ligand	ligand	NN
cord-263645-wupre5uj	90	10	disrupting	disrupt	VBG
cord-263645-wupre5uj	90	11	the	the	DT
cord-263645-wupre5uj	90	12	Rev	Rev	NNP
cord-263645-wupre5uj	90	13	-	-	HYPH
cord-263645-wupre5uj	90	14	RRE	RRE	NNP
cord-263645-wupre5uj	90	15	interaction	interaction	NN
cord-263645-wupre5uj	90	16	in	in	IN
cord-263645-wupre5uj	90	17	vitro	vitro	FW
cord-263645-wupre5uj	90	18	(	(	-LRB-
cord-263645-wupre5uj	90	19	IC	IC	NNP
cord-263645-wupre5uj	90	20	50	50	CD
cord-263645-wupre5uj	90	21	=	=	SYM
cord-263645-wupre5uj	90	22	6.8	6.8	CD
cord-263645-wupre5uj	90	23	M	M	NNP
cord-263645-wupre5uj	90	24	)	)	-RRB-
cord-263645-wupre5uj	90	25	,	,	,
cord-263645-wupre5uj	90	26	inhibiting	inhibit	VBG
cord-263645-wupre5uj	90	27	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	90	28	replication	replication	NN
cord-263645-wupre5uj	90	29	(	(	-LRB-
cord-263645-wupre5uj	90	30	IC	IC	NNP
cord-263645-wupre5uj	90	31	50	50	CD
cord-263645-wupre5uj	90	32	values	value	NNS
cord-263645-wupre5uj	90	33	of	of	IN
cord-263645-wupre5uj	90	34	3.4	3.4	CD
cord-263645-wupre5uj	90	35	-	-	SYM
cord-263645-wupre5uj	90	36	5.9	5.9	CD
cord-263645-wupre5uj	90	37	M	M	NNP
cord-263645-wupre5uj	90	38	)	)	-RRB-
cord-263645-wupre5uj	90	39	,	,	,
cord-263645-wupre5uj	90	40	and	and	CC
cord-263645-wupre5uj	90	41	exhibiting	exhibit	VBG
cord-263645-wupre5uj	90	42	on	on	IN
cord-263645-wupre5uj	90	43	-	-	HYPH
cord-263645-wupre5uj	90	44	target	target	NN
cord-263645-wupre5uj	90	45	effects	effect	NNS
cord-263645-wupre5uj	90	46	via	via	IN
cord-263645-wupre5uj	90	47	a	a	DT
cord-263645-wupre5uj	90	48	RRE	rre	NN
cord-263645-wupre5uj	90	49	-	-	HYPH
cord-263645-wupre5uj	90	50	luciferase	luciferase	JJ
cord-263645-wupre5uj	90	51	reporter	reporter	NN
cord-263645-wupre5uj	90	52	assay	assay	NN
cord-263645-wupre5uj	90	53	(	(	-LRB-
cord-263645-wupre5uj	90	54	IC	IC	NNP
cord-263645-wupre5uj	90	55	50	50	CD
cord-263645-wupre5uj	90	56	values	value	NNS
cord-263645-wupre5uj	90	57	of	of	IN
cord-263645-wupre5uj	90	58	10	10	CD
cord-263645-wupre5uj	90	59	-	-	SYM
cord-263645-wupre5uj	90	60	21	21	CD
cord-263645-wupre5uj	90	61	M	M	NNP
cord-263645-wupre5uj	90	62	)	)	-RRB-
cord-263645-wupre5uj	90	63	.	.	.
cord-263645-wupre5uj	91	1	Further	further	RB
cord-263645-wupre5uj	91	2	,	,	,
cord-263645-wupre5uj	91	3	we	-PRON-	PRP
cord-263645-wupre5uj	91	4	did	do	VBD
cord-263645-wupre5uj	91	5	not	not	RB
cord-263645-wupre5uj	91	6	identify	identify	VB
cord-263645-wupre5uj	91	7	successful	successful	JJ
cord-263645-wupre5uj	91	8	reports	report	NNS
cord-263645-wupre5uj	91	9	of	of	IN
cord-263645-wupre5uj	91	10	biologically	biologically	RB
cord-263645-wupre5uj	91	11	active	active	JJ
cord-263645-wupre5uj	91	12	ligands	ligand	NNS
cord-263645-wupre5uj	91	13	from	from	IN
cord-263645-wupre5uj	91	14	small	small	JJ
cord-263645-wupre5uj	91	15	molecule	molecule	NN
cord-263645-wupre5uj	91	16	libraries	library	NNS
cord-263645-wupre5uj	91	17	biased	bias	VBN
cord-263645-wupre5uj	91	18	to	to	IN
cord-263645-wupre5uj	91	19	general	general	JJ
cord-263645-wupre5uj	91	20	RNAbinding	rnabinding	NN
cord-263645-wupre5uj	91	21	.	.	.
cord-263645-wupre5uj	92	1	Recently	recently	RB
cord-263645-wupre5uj	92	2	,	,	,
cord-263645-wupre5uj	92	3	chemical	chemical	NN
cord-263645-wupre5uj	92	4	companies	company	NNS
cord-263645-wupre5uj	92	5	have	have	VBP
cord-263645-wupre5uj	92	6	designed	design	VBN
cord-263645-wupre5uj	92	7	such	such	JJ
cord-263645-wupre5uj	92	8	focused	focus	VBN
cord-263645-wupre5uj	92	9	libraries	library	NNS
cord-263645-wupre5uj	92	10	(	(	-LRB-
cord-263645-wupre5uj	92	11	ChemDiv	ChemDiv	NNP
cord-263645-wupre5uj	92	12	,	,	,
cord-263645-wupre5uj	92	13	Nucleic	Nucleic	NNP
cord-263645-wupre5uj	92	14	Acid	acid	NN
cord-263645-wupre5uj	92	15	Ligands	Ligands	NNPS
cord-263645-wupre5uj	92	16	:	:	:
cord-263645-wupre5uj	92	17	http://www.chemdiv.com/nucleic-acid-ligands/	http://www.chemdiv.com/nucleic-acid-ligands/	NN
cord-263645-wupre5uj	92	18	;	;	:
cord-263645-wupre5uj	92	19	Otava	Otava	NNP
cord-263645-wupre5uj	92	20	Chemicals	Chemicals	NNPS
cord-263645-wupre5uj	92	21	,	,	,
cord-263645-wupre5uj	92	22	RNA	RNA	NNP
cord-263645-wupre5uj	92	23	Targeted	Targeted	NNP
cord-263645-wupre5uj	92	24	Library	Library	NNP
cord-263645-wupre5uj	92	25	:	:	:
cord-263645-wupre5uj	92	26	http	http	NNP
cord-263645-wupre5uj	92	27	:	:	:
cord-263645-wupre5uj	92	28	//www.otavachemicals.com	//www.otavachemicals.com	.
cord-263645-wupre5uj	92	29	/	/	SYM
cord-263645-wupre5uj	92	30	products	product	NNS
cord-263645-wupre5uj	92	31	/	/	SYM
cord-263645-wupre5uj	92	32	targeted	target	VBN
cord-263645-wupre5uj	92	33	-	-	HYPH
cord-263645-wupre5uj	92	34	librariesand	librariesand	NN
cord-263645-wupre5uj	92	35	-	-	HYPH
cord-263645-wupre5uj	92	36	focused	focus	VBN
cord-263645-wupre5uj	92	37	-	-	HYPH
cord-263645-wupre5uj	92	38	libraries	library	NNS
cord-263645-wupre5uj	92	39	/	/	SYM
cord-263645-wupre5uj	92	40	rna	rna	NN
cord-263645-wupre5uj	92	41	-	-	HYPH
cord-263645-wupre5uj	92	42	binding	bind	VBG
cord-263645-wupre5uj	92	43	)	)	-RRB-
cord-263645-wupre5uj	92	44	;	;	:
cord-263645-wupre5uj	92	45	however	however	RB
cord-263645-wupre5uj	92	46	,	,	,
cord-263645-wupre5uj	92	47	the	the	DT
cord-263645-wupre5uj	92	48	success	success	NN
cord-263645-wupre5uj	92	49	of	of	IN
cord-263645-wupre5uj	92	50	these	these	DT
cord-263645-wupre5uj	92	51	libraries	library	NNS
cord-263645-wupre5uj	92	52	is	be	VBZ
cord-263645-wupre5uj	92	53	yet	yet	RB
cord-263645-wupre5uj	92	54	to	to	TO
cord-263645-wupre5uj	92	55	be	be	VB
cord-263645-wupre5uj	92	56	reported	report	VBN
cord-263645-wupre5uj	92	57	.	.	.
cord-263645-wupre5uj	93	1	To	to	IN
cord-263645-wupre5uj	93	2	date	date	NN
cord-263645-wupre5uj	93	3	,	,	,
cord-263645-wupre5uj	93	4	successful	successful	JJ
cord-263645-wupre5uj	93	5	FcS	fcs	NN
cord-263645-wupre5uj	93	6	strategies	strategy	NNS
cord-263645-wupre5uj	93	7	have	have	VBP
cord-263645-wupre5uj	93	8	utilized	utilize	VBN
cord-263645-wupre5uj	93	9	knowledge	knowledge	NN
cord-263645-wupre5uj	93	10	of	of	IN
cord-263645-wupre5uj	93	11	the	the	DT
cord-263645-wupre5uj	93	12	RNA	RNA	NNP
cord-263645-wupre5uj	93	13	structure	structure	NN
cord-263645-wupre5uj	93	14	and/or	and/or	CC
cord-263645-wupre5uj	93	15	a	a	DT
cord-263645-wupre5uj	93	16	small	small	JJ
cord-263645-wupre5uj	93	17	molecule	molecule	NN
cord-263645-wupre5uj	93	18	binder(s	binder(s	NN
cord-263645-wupre5uj	93	19	)	)	-RRB-
cord-263645-wupre5uj	93	20	,	,	,
cord-263645-wupre5uj	93	21	neither	neither	DT
cord-263645-wupre5uj	93	22	of	of	IN
cord-263645-wupre5uj	93	23	which	which	WDT
cord-263645-wupre5uj	93	24	is	be	VBZ
cord-263645-wupre5uj	93	25	known	know	VBN
cord-263645-wupre5uj	93	26	for	for	IN
cord-263645-wupre5uj	93	27	many	many	JJ
cord-263645-wupre5uj	93	28	therapeutically	therapeutically	RB
cord-263645-wupre5uj	93	29	-	-	HYPH
cord-263645-wupre5uj	93	30	relevant	relevant	JJ
cord-263645-wupre5uj	93	31	RNAs	rna	NNS
cord-263645-wupre5uj	93	32	.	.	.
cord-263645-wupre5uj	94	1	The	the	DT
cord-263645-wupre5uj	94	2	primary	primary	JJ
cord-263645-wupre5uj	94	3	screening	screening	NN
cord-263645-wupre5uj	94	4	assay	assay	NN
cord-263645-wupre5uj	94	5	for	for	IN
cord-263645-wupre5uj	94	6	each	each	DT
cord-263645-wupre5uj	94	7	small	small	JJ
cord-263645-wupre5uj	94	8	molecule	molecule	NN
cord-263645-wupre5uj	94	9	was	be	VBD
cord-263645-wupre5uj	94	10	categorized	categorize	VBN
cord-263645-wupre5uj	94	11	as	as	IN
cord-263645-wupre5uj	94	12	computational	computational	JJ
cord-263645-wupre5uj	94	13	,	,	,
cord-263645-wupre5uj	94	14	in	in	IN
cord-263645-wupre5uj	94	15	vitro	vitro	FW
cord-263645-wupre5uj	94	16	,	,	,
cord-263645-wupre5uj	94	17	or	or	CC
cord-263645-wupre5uj	94	18	cell	cell	NN
cord-263645-wupre5uj	94	19	-	-	HYPH
cord-263645-wupre5uj	94	20	based	base	VBN
cord-263645-wupre5uj	94	21	[	[	-LRB-
cord-263645-wupre5uj	94	22	Figure	figure	NN
cord-263645-wupre5uj	94	23	 	 	_SP
cord-263645-wupre5uj	94	24	4A	4a	CD
cord-263645-wupre5uj	94	25	]	]	-RRB-
cord-263645-wupre5uj	94	26	.	.	.
cord-263645-wupre5uj	95	1	This	this	DT
cord-263645-wupre5uj	95	2	list	list	NN
cord-263645-wupre5uj	95	3	contained	contain	VBD
cord-263645-wupre5uj	95	4	a	a	DT
cord-263645-wupre5uj	95	5	wide	wide	JJ
cord-263645-wupre5uj	95	6	range	range	NN
cord-263645-wupre5uj	95	7	of	of	IN
cord-263645-wupre5uj	95	8	primary	primary	JJ
cord-263645-wupre5uj	95	9	screening	screening	NN
cord-263645-wupre5uj	95	10	assays	assay	NNS
cord-263645-wupre5uj	95	11	,	,	,
cord-263645-wupre5uj	95	12	with	with	IN
cord-263645-wupre5uj	95	13	limited	limited	JJ
cord-263645-wupre5uj	95	14	examples	example	NNS
cord-263645-wupre5uj	95	15	of	of	IN
cord-263645-wupre5uj	95	16	the	the	DT
cord-263645-wupre5uj	95	17	same	same	JJ
cord-263645-wupre5uj	95	18	assay	assay	NN
cord-263645-wupre5uj	95	19	being	be	VBG
cord-263645-wupre5uj	95	20	used	use	VBN
cord-263645-wupre5uj	95	21	for	for	IN
cord-263645-wupre5uj	95	22	multiple	multiple	JJ
cord-263645-wupre5uj	95	23	targets	target	NNS
cord-263645-wupre5uj	95	24	.	.	.
cord-263645-wupre5uj	96	1	The	the	DT
cord-263645-wupre5uj	96	2	majority	majority	NN
cord-263645-wupre5uj	96	3	of	of	IN
cord-263645-wupre5uj	96	4	the	the	DT
cord-263645-wupre5uj	96	5	chemical	chemical	NN
cord-263645-wupre5uj	96	6	probes	probe	NNS
cord-263645-wupre5uj	96	7	were	be	VBD
cord-263645-wupre5uj	96	8	discovered	discover	VBN
cord-263645-wupre5uj	96	9	by	by	IN
cord-263645-wupre5uj	96	10	in	in	FW
cord-263645-wupre5uj	96	11	vitro	vitro	FW
cord-263645-wupre5uj	96	12	primary	primary	JJ
cord-263645-wupre5uj	96	13	screening	screening	NN
cord-263645-wupre5uj	96	14	assays	assay	NNS
cord-263645-wupre5uj	97	1	(	(	-LRB-
cord-263645-wupre5uj	97	2	n	n	NN
cord-263645-wupre5uj	97	3	=	=	SYM
cord-263645-wupre5uj	97	4	28	28	CD
cord-263645-wupre5uj	97	5	)	)	-RRB-
cord-263645-wupre5uj	97	6	with	with	IN
cord-263645-wupre5uj	97	7	fewer	few	JJR
cord-263645-wupre5uj	97	8	in	in	IN
cord-263645-wupre5uj	97	9	cellulo	cellulo	JJ
cord-263645-wupre5uj	97	10	or	or	CC
cord-263645-wupre5uj	97	11	silico	silico	NN
cord-263645-wupre5uj	97	12	examples	example	NNS
cord-263645-wupre5uj	97	13	.	.	.
cord-263645-wupre5uj	98	1	Of	of	IN
cord-263645-wupre5uj	98	2	those	those	DT
cord-263645-wupre5uj	98	3	in	in	IN
cord-263645-wupre5uj	98	4	vitro	vitro	FW
cord-263645-wupre5uj	98	5	primary	primary	JJ
cord-263645-wupre5uj	98	6	screens	screen	NNS
cord-263645-wupre5uj	98	7	,	,	,
cord-263645-wupre5uj	98	8	15	15	CD
cord-263645-wupre5uj	98	9	were	be	VBD
cord-263645-wupre5uj	98	10	RNA	RNA	NNP
cord-263645-wupre5uj	98	11	:	:	:
cord-263645-wupre5uj	98	12	protein	protein	NN
cord-263645-wupre5uj	98	13	displacement	displacement	NN
cord-263645-wupre5uj	98	14	assays	assay	NNS
cord-263645-wupre5uj	98	15	[	[	-LRB-
cord-263645-wupre5uj	98	16	Figure	figure	NN
cord-263645-wupre5uj	98	17	4B	4b	NN
cord-263645-wupre5uj	98	18	]	]	-RRB-
cord-263645-wupre5uj	98	19	.	.	.
cord-263645-wupre5uj	99	1	These	these	DT
cord-263645-wupre5uj	99	2	included	include	VBD
cord-263645-wupre5uj	99	3	fluorescence	fluorescence	NN
cord-263645-wupre5uj	99	4	-	-	HYPH
cord-263645-wupre5uj	99	5	based	base	VBN
cord-263645-wupre5uj	99	6	assays	assay	NNS
cord-263645-wupre5uj	99	7	(	(	-LRB-
cord-263645-wupre5uj	99	8	Förster	Förster	NNP
cord-263645-wupre5uj	99	9	resonance	resonance	NN
cord-263645-wupre5uj	99	10	energy	energy	NN
cord-263645-wupre5uj	99	11	transfer	transfer	NN
cord-263645-wupre5uj	99	12	(	(	-LRB-
cord-263645-wupre5uj	99	13	FRET	fret	NN
cord-263645-wupre5uj	99	14	)	)	-RRB-
cord-263645-wupre5uj	99	15	and	and	CC
cord-263645-wupre5uj	99	16	fluorescence	fluorescence	NN
cord-263645-wupre5uj	99	17	anisotropy	anisotropy	NN
cord-263645-wupre5uj	99	18	)	)	-RRB-
cord-263645-wupre5uj	99	19	and	and	CC
cord-263645-wupre5uj	99	20	radiolabel	radiolabel	NN
cord-263645-wupre5uj	99	21	-	-	HYPH
cord-263645-wupre5uj	99	22	based	base	VBN
cord-263645-wupre5uj	99	23	methods	method	NNS
cord-263645-wupre5uj	99	24	(	(	-LRB-
cord-263645-wupre5uj	99	25	mobility	mobility	NN
cord-263645-wupre5uj	99	26	shift	shift	NN
cord-263645-wupre5uj	99	27	,	,	,
cord-263645-wupre5uj	99	28	scintillation	scintillation	NN
cord-263645-wupre5uj	99	29	proximity	proximity	NN
cord-263645-wupre5uj	99	30	,	,	,
cord-263645-wupre5uj	99	31	and	and	CC
cord-263645-wupre5uj	99	32	filtration	filtration	NN
cord-263645-wupre5uj	99	33	assays	assay	NNS
cord-263645-wupre5uj	99	34	)	)	-RRB-
cord-263645-wupre5uj	99	35	.	.	.
cord-263645-wupre5uj	100	1	One	one	CD
cord-263645-wupre5uj	100	2	rather	rather	RB
cord-263645-wupre5uj	100	3	unique	unique	JJ
cord-263645-wupre5uj	100	4	assay	assay	NN
cord-263645-wupre5uj	100	5	utilized	utilize	VBD
cord-263645-wupre5uj	100	6	a	a	DT
cord-263645-wupre5uj	100	7	molecular	molecular	JJ
cord-263645-wupre5uj	100	8	beacon	beacon	NN
cord-263645-wupre5uj	100	9	approach	approach	NN
cord-263645-wupre5uj	100	10	to	to	TO
cord-263645-wupre5uj	100	11	probe	probe	VB
cord-263645-wupre5uj	100	12	for	for	IN
cord-263645-wupre5uj	100	13	stabilization	stabilization	NN
cord-263645-wupre5uj	100	14	of	of	IN
cord-263645-wupre5uj	100	15	Stem	Stem	NNP
cord-263645-wupre5uj	100	16	Loop	Loop	NNP
cord-263645-wupre5uj	100	17	3	3	CD
cord-263645-wupre5uj	100	18	(	(	-LRB-
cord-263645-wupre5uj	100	19	SL3	SL3	NNP
cord-263645-wupre5uj	100	20	)	)	-RRB-
cord-263645-wupre5uj	100	21	,	,	,
cord-263645-wupre5uj	100	22	a	a	DT
cord-263645-wupre5uj	100	23	presumptive	presumptive	JJ
cord-263645-wupre5uj	100	24	structural	structural	JJ
cord-263645-wupre5uj	100	25	switch	switch	NN
cord-263645-wupre5uj	100	26	located	locate	VBN
cord-263645-wupre5uj	100	27	in	in	IN
cord-263645-wupre5uj	100	28	the	the	DT
cord-263645-wupre5uj	100	29	-Packing	-Packing	NNP
cord-263645-wupre5uj	100	30	Domain	Domain	NNP
cord-263645-wupre5uj	100	31	in	in	IN
cord-263645-wupre5uj	100	32	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	100	33	that	that	WDT
cord-263645-wupre5uj	100	34	is	be	VBZ
cord-263645-wupre5uj	100	35	destabilized	destabilize	VBN
cord-263645-wupre5uj	100	36	by	by	IN
cord-263645-wupre5uj	100	37	binding	bind	VBG
cord-263645-wupre5uj	100	38	of	of	IN
cord-263645-wupre5uj	100	39	the	the	DT
cord-263645-wupre5uj	100	40	Gag	Gag	NNP
cord-263645-wupre5uj	100	41	protein	protein	NN
cord-263645-wupre5uj	100	42	prior	prior	RB
cord-263645-wupre5uj	100	43	to	to	IN
cord-263645-wupre5uj	100	44	packaging	packaging	NN
cord-263645-wupre5uj	100	45	of	of	IN
cord-263645-wupre5uj	100	46	the	the	DT
cord-263645-wupre5uj	100	47	virus	virus	NN
cord-263645-wupre5uj	100	48	(	(	-LRB-
cord-263645-wupre5uj	100	49	49	49	CD
cord-263645-wupre5uj	100	50	)	)	-RRB-
cord-263645-wupre5uj	100	51	.	.	.
cord-263645-wupre5uj	101	1	In	in	IN
cord-263645-wupre5uj	101	2	this	this	DT
cord-263645-wupre5uj	101	3	assay	assay	NN
cord-263645-wupre5uj	101	4	,	,	,
cord-263645-wupre5uj	101	5	the	the	DT
cord-263645-wupre5uj	101	6	5	5	CD
cord-263645-wupre5uj	101	7	-and	-and	SYM
cord-263645-wupre5uj	101	8	3	3	CD
cord-263645-wupre5uj	101	9	-terminal	-terminal	JJ
cord-263645-wupre5uj	101	10	ends	end	NNS
cord-263645-wupre5uj	101	11	of	of	IN
cord-263645-wupre5uj	101	12	the	the	DT
cord-263645-wupre5uj	101	13	SL3	SL3	NNP
cord-263645-wupre5uj	101	14	RNA	RNA	NNP
cord-263645-wupre5uj	101	15	were	be	VBD
cord-263645-wupre5uj	101	16	labeled	label	VBN
cord-263645-wupre5uj	101	17	with	with	IN
cord-263645-wupre5uj	101	18	a	a	DT
cord-263645-wupre5uj	101	19	TET	TET	NNP
cord-263645-wupre5uj	101	20	fluorophore	fluorophore	NN
cord-263645-wupre5uj	101	21	and	and	CC
cord-263645-wupre5uj	101	22	a	a	DT
cord-263645-wupre5uj	101	23	blackhole	blackhole	NN
cord-263645-wupre5uj	101	24	quencher	quencher	NN
cord-263645-wupre5uj	101	25	(	(	-LRB-
cord-263645-wupre5uj	101	26	BHQ1	BHQ1	NNP
cord-263645-wupre5uj	101	27	)	)	-RRB-
cord-263645-wupre5uj	101	28	,	,	,
cord-263645-wupre5uj	101	29	respectively	respectively	RB
cord-263645-wupre5uj	101	30	.	.	.
cord-263645-wupre5uj	102	1	In	in	IN
cord-263645-wupre5uj	102	2	the	the	DT
cord-263645-wupre5uj	102	3	presence	presence	NN
cord-263645-wupre5uj	102	4	of	of	IN
cord-263645-wupre5uj	102	5	Gag	Gag	NNP
cord-263645-wupre5uj	102	6	protein	protein	NN
cord-263645-wupre5uj	102	7	,	,	,
cord-263645-wupre5uj	102	8	the	the	DT
cord-263645-wupre5uj	102	9	RNA	RNA	NNP
cord-263645-wupre5uj	102	10	construct	construct	NN
cord-263645-wupre5uj	102	11	became	become	VBD
cord-263645-wupre5uj	102	12	single	single	JJ
cord-263645-wupre5uj	102	13	stranded	strand	VBN
cord-263645-wupre5uj	102	14	and	and	CC
cord-263645-wupre5uj	102	15	the	the	DT
cord-263645-wupre5uj	102	16	fluorescence	fluorescence	NN
cord-263645-wupre5uj	102	17	was	be	VBD
cord-263645-wupre5uj	102	18	'	'	``
cord-263645-wupre5uj	102	19	turned	turn	VBN
cord-263645-wupre5uj	102	20	on	on	RP
cord-263645-wupre5uj	102	21	'	'	''
cord-263645-wupre5uj	102	22	.	.	.
cord-263645-wupre5uj	103	1	When	when	WRB
cord-263645-wupre5uj	103	2	a	a	DT
cord-263645-wupre5uj	103	3	small	small	JJ
cord-263645-wupre5uj	103	4	molecule	molecule	NN
cord-263645-wupre5uj	103	5	stabilized	stabilize	VBD
cord-263645-wupre5uj	103	6	the	the	DT
cord-263645-wupre5uj	103	7	folded	fold	VBN
cord-263645-wupre5uj	103	8	hairpin	hairpin	NN
cord-263645-wupre5uj	103	9	form	form	NN
cord-263645-wupre5uj	103	10	of	of	IN
cord-263645-wupre5uj	103	11	SL3	SL3	NNP
cord-263645-wupre5uj	103	12	RNA	RNA	NNP
cord-263645-wupre5uj	103	13	,	,	,
cord-263645-wupre5uj	103	14	the	the	DT
cord-263645-wupre5uj	103	15	Gag	gag	NN
cord-263645-wupre5uj	103	16	-	-	HYPH
cord-263645-wupre5uj	103	17	promoted	promote	VBN
cord-263645-wupre5uj	103	18	RNA	RNA	NNP
cord-263645-wupre5uj	103	19	destabilization	destabilization	NN
cord-263645-wupre5uj	103	20	was	be	VBD
cord-263645-wupre5uj	103	21	reduced	reduce	VBN
cord-263645-wupre5uj	103	22	and	and	CC
cord-263645-wupre5uj	103	23	the	the	DT
cord-263645-wupre5uj	103	24	fluorescence	fluorescence	NN
cord-263645-wupre5uj	103	25	was	be	VBD
cord-263645-wupre5uj	103	26	quenched	quench	VBN
cord-263645-wupre5uj	103	27	.	.	.
cord-263645-wupre5uj	104	1	The	the	DT
cord-263645-wupre5uj	104	2	researchers	researcher	NNS
cord-263645-wupre5uj	104	3	screened	screen	VBD
cord-263645-wupre5uj	104	4	a	a	DT
cord-263645-wupre5uj	104	5	modest	modest	JJ
cord-263645-wupre5uj	104	6	sized	sized	JJ
cord-263645-wupre5uj	104	7	library	library	NN
cord-263645-wupre5uj	104	8	(	(	-LRB-
cord-263645-wupre5uj	104	9	>	>	NFP
cord-263645-wupre5uj	104	10	2500	2500	CD
cord-263645-wupre5uj	104	11	small	small	JJ
cord-263645-wupre5uj	104	12	molecules	molecule	NNS
cord-263645-wupre5uj	104	13	)	)	-RRB-
cord-263645-wupre5uj	104	14	and	and	CC
cord-263645-wupre5uj	104	15	discovered	discover	VBD
cord-263645-wupre5uj	104	16	a	a	DT
cord-263645-wupre5uj	104	17	ligand	ligand	NN
cord-263645-wupre5uj	104	18	that	that	WDT
cord-263645-wupre5uj	104	19	reduced	reduce	VBD
cord-263645-wupre5uj	104	20	viral	viral	JJ
cord-263645-wupre5uj	104	21	production	production	NN
cord-263645-wupre5uj	104	22	similar	similar	JJ
cord-263645-wupre5uj	104	23	to	to	IN
cord-263645-wupre5uj	104	24	models	model	NNS
cord-263645-wupre5uj	104	25	with	with	IN
cord-263645-wupre5uj	104	26	a	a	DT
cord-263645-wupre5uj	104	27	mutated	mutate	VBN
cord-263645-wupre5uj	104	28	-Packing	-packing	NN
cord-263645-wupre5uj	104	29	Domain	domain	NN
cord-263645-wupre5uj	104	30	(	(	-LRB-
cord-263645-wupre5uj	104	31	p24	p24	NN
cord-263645-wupre5uj	104	32	50	50	CD
cord-263645-wupre5uj	104	33	=	=	SYM
cord-263645-wupre5uj	104	34	11.3	11.3	CD
cord-263645-wupre5uj	104	35	M	M	NNP
cord-263645-wupre5uj	104	36	)	)	-RRB-
cord-263645-wupre5uj	104	37	.	.	.
cord-263645-wupre5uj	105	1	The	the	DT
cord-263645-wupre5uj	105	2	remaining	remain	VBG
cord-263645-wupre5uj	105	3	in	in	IN
cord-263645-wupre5uj	105	4	vitro	vitro	FW
cord-263645-wupre5uj	105	5	assays	assay	NNS
cord-263645-wupre5uj	105	6	consisted	consist	VBN
cord-263645-wupre5uj	105	7	of	of	IN
cord-263645-wupre5uj	105	8	two	two	CD
cord-263645-wupre5uj	105	9	activitybased	activitybased	JJ
cord-263645-wupre5uj	105	10	screens	screen	NNS
cord-263645-wupre5uj	105	11	and	and	CC
cord-263645-wupre5uj	105	12	various	various	JJ
cord-263645-wupre5uj	105	13	RNA	RNA	NNP
cord-263645-wupre5uj	105	14	binding	bind	VBG
cord-263645-wupre5uj	105	15	assays	assay	NNS
cord-263645-wupre5uj	105	16	[	[	-LRB-
cord-263645-wupre5uj	105	17	Figure	figure	NN
cord-263645-wupre5uj	105	18	(	(	-LRB-
cord-263645-wupre5uj	105	19	v	v	NN
cord-263645-wupre5uj	105	20	)	)	-RRB-
cord-263645-wupre5uj	105	21	competition	competition	NN
cord-263645-wupre5uj	105	22	dialysis	dialysis	NN
cord-263645-wupre5uj	105	23	and	and	CC
cord-263645-wupre5uj	105	24	(	(	-LRB-
cord-263645-wupre5uj	105	25	vi	vi	NNP
cord-263645-wupre5uj	105	26	)	)	-RRB-
cord-263645-wupre5uj	105	27	indicator	indicator	NN
cord-263645-wupre5uj	105	28	displacement	displacement	NN
cord-263645-wupre5uj	105	29	.	.	.
cord-263645-wupre5uj	106	1	We	-PRON-	PRP
cord-263645-wupre5uj	106	2	note	note	VBP
cord-263645-wupre5uj	106	3	that	that	IN
cord-263645-wupre5uj	106	4	a	a	DT
cord-263645-wupre5uj	106	5	lack	lack	NN
cord-263645-wupre5uj	106	6	of	of	IN
cord-263645-wupre5uj	106	7	correlation	correlation	NN
cord-263645-wupre5uj	106	8	in	in	IN
cord-263645-wupre5uj	106	9	small	small	JJ
cord-263645-wupre5uj	106	10	molecule	molecule	NN
cord-263645-wupre5uj	106	11	activity	activity	NN
cord-263645-wupre5uj	106	12	between	between	IN
cord-263645-wupre5uj	106	13	in	in	IN
cord-263645-wupre5uj	106	14	vitro	vitro	FW
cord-263645-wupre5uj	106	15	RNA	RNA	NNP
cord-263645-wupre5uj	106	16	binding	binding	NN
cord-263645-wupre5uj	106	17	and	and	CC
cord-263645-wupre5uj	106	18	RNA	RNA	NNP
cord-263645-wupre5uj	106	19	:	:	:
cord-263645-wupre5uj	106	20	protein	protein	NN
cord-263645-wupre5uj	106	21	displacement	displacement	NN
cord-263645-wupre5uj	106	22	assays	assay	NNS
cord-263645-wupre5uj	106	23	has	have	VBZ
cord-263645-wupre5uj	106	24	sometimes	sometimes	RB
cord-263645-wupre5uj	106	25	been	be	VBN
cord-263645-wupre5uj	106	26	reported	report	VBN
cord-263645-wupre5uj	106	27	,	,	,
cord-263645-wupre5uj	106	28	(	(	-LRB-
cord-263645-wupre5uj	106	29	16	16	CD
cord-263645-wupre5uj	106	30	,	,	,
cord-263645-wupre5uj	106	31	51	51	CD
cord-263645-wupre5uj	106	32	,	,	,
cord-263645-wupre5uj	106	33	52	52	CD
cord-263645-wupre5uj	106	34	)	)	-RRB-
cord-263645-wupre5uj	106	35	highlighting	highlight	VBG
cord-263645-wupre5uj	106	36	the	the	DT
cord-263645-wupre5uj	106	37	importance	importance	NN
cord-263645-wupre5uj	106	38	of	of	IN
cord-263645-wupre5uj	106	39	multiple	multiple	JJ
cord-263645-wupre5uj	106	40	assays	assay	NNS
cord-263645-wupre5uj	106	41	and/or	and/or	CC
cord-263645-wupre5uj	106	42	choosing	choose	VBG
cord-263645-wupre5uj	106	43	the	the	DT
cord-263645-wupre5uj	106	44	most	most	RBS
cord-263645-wupre5uj	106	45	relevant	relevant	JJ
cord-263645-wupre5uj	106	46	assay	assay	NN
cord-263645-wupre5uj	106	47	for	for	IN
cord-263645-wupre5uj	106	48	a	a	DT
cord-263645-wupre5uj	106	49	particular	particular	JJ
cord-263645-wupre5uj	106	50	system	system	NN
cord-263645-wupre5uj	106	51	.	.	.
cord-263645-wupre5uj	107	1	We	-PRON-	PRP
cord-263645-wupre5uj	107	2	also	also	RB
cord-263645-wupre5uj	107	3	note	note	VBP
cord-263645-wupre5uj	107	4	that	that	IN
cord-263645-wupre5uj	107	5	,	,	,
cord-263645-wupre5uj	107	6	as	as	IN
cord-263645-wupre5uj	107	7	in	in	IN
cord-263645-wupre5uj	107	8	all	all	DT
cord-263645-wupre5uj	107	9	screens	screen	NNS
cord-263645-wupre5uj	107	10	,	,	,
cord-263645-wupre5uj	107	11	a	a	DT
cord-263645-wupre5uj	107	12	lack	lack	NN
cord-263645-wupre5uj	107	13	of	of	IN
cord-263645-wupre5uj	107	14	correlation	correlation	NN
cord-263645-wupre5uj	107	15	can	can	MD
cord-263645-wupre5uj	107	16	be	be	VB
cord-263645-wupre5uj	107	17	observed	observe	VBN
cord-263645-wupre5uj	107	18	between	between	IN
cord-263645-wupre5uj	107	19	in	in	IN
cord-263645-wupre5uj	107	20	vitro	vitro	FW
cord-263645-wupre5uj	107	21	activity	activity	NN
cord-263645-wupre5uj	107	22	and	and	CC
cord-263645-wupre5uj	107	23	cell	cell	NN
cord-263645-wupre5uj	107	24	culture	culture	NN
cord-263645-wupre5uj	107	25	activity	activity	NN
cord-263645-wupre5uj	107	26	.	.	.
cord-263645-wupre5uj	108	1	These	these	DT
cord-263645-wupre5uj	108	2	differences	difference	NNS
cord-263645-wupre5uj	108	3	can	can	MD
cord-263645-wupre5uj	108	4	be	be	VB
cord-263645-wupre5uj	108	5	attributed	attribute	VBN
cord-263645-wupre5uj	108	6	to	to	IN
cord-263645-wupre5uj	108	7	many	many	JJ
cord-263645-wupre5uj	108	8	factors	factor	NNS
cord-263645-wupre5uj	108	9	,	,	,
cord-263645-wupre5uj	108	10	including	include	VBG
cord-263645-wupre5uj	108	11	small	small	JJ
cord-263645-wupre5uj	108	12	molecule	molecule	NN
cord-263645-wupre5uj	108	13	uptake	uptake	NN
cord-263645-wupre5uj	108	14	,	,	,
cord-263645-wupre5uj	108	15	localization	localization	NN
cord-263645-wupre5uj	108	16	,	,	,
cord-263645-wupre5uj	108	17	and	and	CC
cord-263645-wupre5uj	108	18	metabolism	metabolism	NN
cord-263645-wupre5uj	108	19	,	,	,
cord-263645-wupre5uj	108	20	specificity	specificity	NN
cord-263645-wupre5uj	108	21	or	or	CC
cord-263645-wupre5uj	108	22	off	off	IN
cord-263645-wupre5uj	108	23	-	-	HYPH
cord-263645-wupre5uj	108	24	target	target	NN
cord-263645-wupre5uj	108	25	effects	effect	NNS
cord-263645-wupre5uj	108	26	,	,	,
cord-263645-wupre5uj	108	27	and	and	CC
cord-263645-wupre5uj	108	28	target	target	VB
cord-263645-wupre5uj	108	29	availability	availability	NN
cord-263645-wupre5uj	108	30	due	due	JJ
cord-263645-wupre5uj	108	31	to	to	IN
cord-263645-wupre5uj	108	32	binding	bind	VBG
cord-263645-wupre5uj	108	33	of	of	IN
cord-263645-wupre5uj	108	34	other	other	JJ
cord-263645-wupre5uj	108	35	macromolecules	macromolecule	NNS
cord-263645-wupre5uj	108	36	or	or	CC
cord-263645-wupre5uj	108	37	metabolites	metabolite	NNS
cord-263645-wupre5uj	108	38	.	.	.
cord-263645-wupre5uj	109	1	Nonetheless	nonetheless	RB
cord-263645-wupre5uj	109	2	,	,	,
cord-263645-wupre5uj	109	3	we	-PRON-	PRP
cord-263645-wupre5uj	109	4	emphasize	emphasize	VBP
cord-263645-wupre5uj	109	5	the	the	DT
cord-263645-wupre5uj	109	6	success	success	NN
cord-263645-wupre5uj	109	7	of	of	IN
cord-263645-wupre5uj	109	8	the	the	DT
cord-263645-wupre5uj	109	9	in	in	FW
cord-263645-wupre5uj	109	10	vitro	vitro	FW
cord-263645-wupre5uj	109	11	assays	assay	NNS
cord-263645-wupre5uj	109	12	mentioned	mention	VBN
cord-263645-wupre5uj	109	13	here	here	RB
cord-263645-wupre5uj	109	14	in	in	IN
cord-263645-wupre5uj	109	15	developing	develop	VBG
cord-263645-wupre5uj	109	16	RNA	RNA	NNP
cord-263645-wupre5uj	109	17	bioactives	bioactive	NNS
cord-263645-wupre5uj	109	18	and	and	CC
cord-263645-wupre5uj	109	19	the	the	DT
cord-263645-wupre5uj	109	20	valuable	valuable	JJ
cord-263645-wupre5uj	109	21	insights	insight	NNS
cord-263645-wupre5uj	109	22	gained	gain	VBD
cord-263645-wupre5uj	109	23	from	from	IN
cord-263645-wupre5uj	109	24	other	other	JJ
cord-263645-wupre5uj	109	25	ligands	ligand	NNS
cord-263645-wupre5uj	109	26	discovered	discover	VBN
cord-263645-wupre5uj	109	27	by	by	IN
cord-263645-wupre5uj	109	28	in	in	FW
cord-263645-wupre5uj	109	29	vitro	vitro	FW
cord-263645-wupre5uj	109	30	RNA	rna	NN
cord-263645-wupre5uj	109	31	assays	assay	NNS
cord-263645-wupre5uj	109	32	without	without	IN
cord-263645-wupre5uj	109	33	reported	report	VBN
cord-263645-wupre5uj	109	34	biological	biological	JJ
cord-263645-wupre5uj	109	35	activity	activity	NN
cord-263645-wupre5uj	109	36	.	.	.
cord-263645-wupre5uj	110	1	Cell	cell	NN
cord-263645-wupre5uj	110	2	-	-	HYPH
cord-263645-wupre5uj	110	3	based	base	VBN
cord-263645-wupre5uj	110	4	screens	screen	NNS
cord-263645-wupre5uj	110	5	were	be	VBD
cord-263645-wupre5uj	110	6	the	the	DT
cord-263645-wupre5uj	110	7	second	second	JJ
cord-263645-wupre5uj	110	8	most	most	RBS
cord-263645-wupre5uj	110	9	common	common	JJ
cord-263645-wupre5uj	110	10	primary	primary	JJ
cord-263645-wupre5uj	110	11	screening	screening	NN
cord-263645-wupre5uj	110	12	assay	assay	NN
cord-263645-wupre5uj	110	13	for	for	IN
cord-263645-wupre5uj	110	14	HTS	HTS	NNP
cord-263645-wupre5uj	110	15	or	or	CC
cord-263645-wupre5uj	110	16	FcS	fcs	NN
cord-263645-wupre5uj	110	17	approaches	approach	NNS
cord-263645-wupre5uj	110	18	[	[	-LRB-
cord-263645-wupre5uj	110	19	Figure	figure	NN
cord-263645-wupre5uj	110	20	4A	4a	CD
cord-263645-wupre5uj	110	21	]	]	-RRB-
cord-263645-wupre5uj	110	22	and	and	CC
cord-263645-wupre5uj	110	23	often	often	RB
cord-263645-wupre5uj	110	24	the	the	DT
cord-263645-wupre5uj	110	25	preferred	preferred	JJ
cord-263645-wupre5uj	110	26	screen	screen	NN
cord-263645-wupre5uj	110	27	for	for	IN
cord-263645-wupre5uj	110	28	bacterial	bacterial	JJ
cord-263645-wupre5uj	110	29	and	and	CC
cord-263645-wupre5uj	110	30	viral	viral	JJ
cord-263645-wupre5uj	110	31	RNA	RNA	NNP
cord-263645-wupre5uj	110	32	targets	target	NNS
cord-263645-wupre5uj	110	33	.	.	.
cord-263645-wupre5uj	111	1	The	the	DT
cord-263645-wupre5uj	111	2	exception	exception	NN
cord-263645-wupre5uj	111	3	was	be	VBD
cord-263645-wupre5uj	111	4	a	a	DT
cord-263645-wupre5uj	111	5	splicing	splicing	NN
cord-263645-wupre5uj	111	6	assay	assay	NN
cord-263645-wupre5uj	111	7	of	of	IN
cord-263645-wupre5uj	111	8	human	human	JJ
cord-263645-wupre5uj	111	9	serotonin	serotonin	NN
cord-263645-wupre5uj	111	10	receptor	receptor	NNP
cord-263645-wupre5uj	111	11	2C	2C	NNP
cord-263645-wupre5uj	111	12	(	(	-LRB-
cord-263645-wupre5uj	111	13	HTR2c	HTR2c	NNP
cord-263645-wupre5uj	111	14	)	)	-RRB-
cord-263645-wupre5uj	112	1	mRNA	mrna	NN
cord-263645-wupre5uj	112	2	where	where	WRB
cord-263645-wupre5uj	112	3	a	a	DT
cord-263645-wupre5uj	112	4	green	green	JJ
cord-263645-wupre5uj	112	5	fluorescent	fluorescent	NN
cord-263645-wupre5uj	112	6	protein	protein	NN
cord-263645-wupre5uj	112	7	(	(	-LRB-
cord-263645-wupre5uj	112	8	GFP	GFP	NNP
cord-263645-wupre5uj	112	9	)	)	-RRB-
cord-263645-wupre5uj	112	10	reporter	reporter	NN
cord-263645-wupre5uj	112	11	was	be	VBD
cord-263645-wupre5uj	112	12	used	use	VBN
cord-263645-wupre5uj	112	13	to	to	TO
cord-263645-wupre5uj	112	14	evaluate	evaluate	VB
cord-263645-wupre5uj	112	15	the	the	DT
cord-263645-wupre5uj	112	16	inclusion	inclusion	NN
cord-263645-wupre5uj	112	17	or	or	CC
cord-263645-wupre5uj	112	18	exclusion	exclusion	NN
cord-263645-wupre5uj	112	19	of	of	IN
cord-263645-wupre5uj	112	20	a	a	DT
cord-263645-wupre5uj	112	21	particular	particular	JJ
cord-263645-wupre5uj	112	22	exon	exon	NN
cord-263645-wupre5uj	112	23	(	(	-LRB-
cord-263645-wupre5uj	112	24	53	53	CD
cord-263645-wupre5uj	112	25	)	)	-RRB-
cord-263645-wupre5uj	112	26	.	.	.
cord-263645-wupre5uj	113	1	Bacterial	bacterial	JJ
cord-263645-wupre5uj	113	2	and	and	CC
cord-263645-wupre5uj	113	3	viral	viral	JJ
cord-263645-wupre5uj	113	4	RNA	RNA	NNP
cord-263645-wupre5uj	113	5	cell	cell	NN
cord-263645-wupre5uj	113	6	-	-	HYPH
cord-263645-wupre5uj	113	7	based	base	VBN
cord-263645-wupre5uj	113	8	studies	study	NNS
cord-263645-wupre5uj	113	9	also	also	RB
cord-263645-wupre5uj	113	10	utilized	utilize	VBD
cord-263645-wupre5uj	113	11	reporter	reporter	NN
cord-263645-wupre5uj	113	12	systems	system	NNS
cord-263645-wupre5uj	113	13	such	such	JJ
cord-263645-wupre5uj	113	14	as	as	IN
cord-263645-wupre5uj	113	15	GFP	GFP	NNP
cord-263645-wupre5uj	113	16	or	or	CC
cord-263645-wupre5uj	113	17	LacZ	LacZ	NNP
cord-263645-wupre5uj	113	18	gene	gene	NN
cord-263645-wupre5uj	113	19	as	as	RB
cord-263645-wupre5uj	113	20	well	well	RB
cord-263645-wupre5uj	113	21	as	as	IN
cord-263645-wupre5uj	113	22	more	more	RBR
cord-263645-wupre5uj	113	23	traditional	traditional	JJ
cord-263645-wupre5uj	113	24	phenotypic	phenotypic	JJ
cord-263645-wupre5uj	113	25	screens	screen	NNS
cord-263645-wupre5uj	113	26	,	,	,
cord-263645-wupre5uj	113	27	such	such	JJ
cord-263645-wupre5uj	113	28	as	as	IN
cord-263645-wupre5uj	113	29	growth	growth	NN
cord-263645-wupre5uj	113	30	inhibition	inhibition	NN
cord-263645-wupre5uj	113	31	or	or	CC
cord-263645-wupre5uj	113	32	cell	cell	NN
cord-263645-wupre5uj	113	33	death	death	NN
cord-263645-wupre5uj	113	34	.	.	.
cord-263645-wupre5uj	114	1	In	in	IN
cord-263645-wupre5uj	114	2	one	one	CD
cord-263645-wupre5uj	114	3	particular	particular	JJ
cord-263645-wupre5uj	114	4	example	example	NN
cord-263645-wupre5uj	114	5	,	,	,
cord-263645-wupre5uj	114	6	∼57	∼57	NN
cord-263645-wupre5uj	114	7	000	000	CD
cord-263645-wupre5uj	114	8	ligands	ligand	NNS
cord-263645-wupre5uj	114	9	were	be	VBD
cord-263645-wupre5uj	114	10	screened	screen	VBN
cord-263645-wupre5uj	114	11	in	in	IN
cord-263645-wupre5uj	114	12	a	a	DT
cord-263645-wupre5uj	114	13	growth	growth	NN
cord-263645-wupre5uj	114	14	inhibition	inhibition	NN
cord-263645-wupre5uj	114	15	assay	assay	NN
cord-263645-wupre5uj	114	16	against	against	IN
cord-263645-wupre5uj	114	17	Escherichia	Escherichia	NNP
cord-263645-wupre5uj	114	18	coli	coli	NNS
cord-263645-wupre5uj	114	19	with	with	IN
cord-263645-wupre5uj	114	20	and	and	CC
cord-263645-wupre5uj	114	21	without	without	IN
cord-263645-wupre5uj	114	22	supplementation	supplementation	NN
cord-263645-wupre5uj	114	23	of	of	IN
cord-263645-wupre5uj	114	24	riboflavin	riboflavin	NN
cord-263645-wupre5uj	114	25	(	(	-LRB-
cord-263645-wupre5uj	114	26	15	15	CD
cord-263645-wupre5uj	114	27	)	)	-RRB-
cord-263645-wupre5uj	114	28	.	.	.
cord-263645-wupre5uj	115	1	This	this	DT
cord-263645-wupre5uj	115	2	differential	differential	JJ
cord-263645-wupre5uj	115	3	supplementation	supplementation	NN
cord-263645-wupre5uj	115	4	allowed	allow	VBD
cord-263645-wupre5uj	115	5	researchers	researcher	NNS
cord-263645-wupre5uj	115	6	to	to	TO
cord-263645-wupre5uj	115	7	specifically	specifically	RB
cord-263645-wupre5uj	115	8	probe	probe	VB
cord-263645-wupre5uj	115	9	the	the	DT
cord-263645-wupre5uj	115	10	riboflavin	riboflavin	NN
cord-263645-wupre5uj	115	11	pathway	pathway	NN
cord-263645-wupre5uj	115	12	and	and	CC
cord-263645-wupre5uj	115	13	confirm	confirm	VB
cord-263645-wupre5uj	115	14	the	the	DT
cord-263645-wupre5uj	115	15	FMN	fmn	NN
cord-263645-wupre5uj	115	16	riboswitch	riboswitch	NN
cord-263645-wupre5uj	115	17	was	be	VBD
cord-263645-wupre5uj	115	18	targeted	target	VBN
cord-263645-wupre5uj	115	19	by	by	IN
cord-263645-wupre5uj	115	20	Ribocil	Ribocil	NNP
cord-263645-wupre5uj	115	21	-	-	HYPH
cord-263645-wupre5uj	115	22	B.	B.	NNP
cord-263645-wupre5uj	116	1	In	in	IN
cord-263645-wupre5uj	116	2	addition	addition	NN
cord-263645-wupre5uj	116	3	,	,	,
cord-263645-wupre5uj	116	4	one	one	CD
cord-263645-wupre5uj	116	5	report	report	NN
cord-263645-wupre5uj	116	6	measured	measure	VBN
cord-263645-wupre5uj	116	7	enzyme	enzyme	NN
cord-263645-wupre5uj	116	8	activity	activity	NN
cord-263645-wupre5uj	116	9	and	and	CC
cord-263645-wupre5uj	116	10	antigen	antigen	NN
cord-263645-wupre5uj	116	11	production	production	NN
cord-263645-wupre5uj	116	12	in	in	IN
cord-263645-wupre5uj	116	13	addition	addition	NN
cord-263645-wupre5uj	116	14	to	to	IN
cord-263645-wupre5uj	116	15	cell	cell	NN
cord-263645-wupre5uj	116	16	death	death	NN
cord-263645-wupre5uj	116	17	measurements	measurement	NNS
cord-263645-wupre5uj	116	18	to	to	TO
cord-263645-wupre5uj	116	19	assess	assess	VB
cord-263645-wupre5uj	116	20	antiviral	antiviral	JJ
cord-263645-wupre5uj	116	21	activity	activity	NN
cord-263645-wupre5uj	116	22	against	against	IN
cord-263645-wupre5uj	116	23	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	116	24	(	(	-LRB-
cord-263645-wupre5uj	116	25	30	30	CD
cord-263645-wupre5uj	116	26	)	)	-RRB-
cord-263645-wupre5uj	116	27	.	.	.
cord-263645-wupre5uj	117	1	Given	give	VBN
cord-263645-wupre5uj	117	2	these	these	DT
cord-263645-wupre5uj	117	3	successes	success	NNS
cord-263645-wupre5uj	117	4	,	,	,
cord-263645-wupre5uj	117	5	cell	cell	NN
cord-263645-wupre5uj	117	6	-	-	HYPH
cord-263645-wupre5uj	117	7	based	base	VBN
cord-263645-wupre5uj	117	8	assays	assay	NNS
cord-263645-wupre5uj	117	9	likely	likely	RB
cord-263645-wupre5uj	117	10	offer	offer	VBP
cord-263645-wupre5uj	117	11	unforeseen	unforeseen	JJ
cord-263645-wupre5uj	117	12	promises	promise	NNS
cord-263645-wupre5uj	117	13	as	as	IN
cord-263645-wupre5uj	117	14	primary	primary	JJ
cord-263645-wupre5uj	117	15	screening	screening	NN
cord-263645-wupre5uj	117	16	assays	assay	NNS
cord-263645-wupre5uj	117	17	to	to	TO
cord-263645-wupre5uj	117	18	discover	discover	VB
cord-263645-wupre5uj	117	19	RNA	RNA	NNP
cord-263645-wupre5uj	117	20	-	-	HYPH
cord-263645-wupre5uj	117	21	targeted	target	VBN
cord-263645-wupre5uj	117	22	probes	probe	NNS
cord-263645-wupre5uj	117	23	.	.	.
cord-263645-wupre5uj	118	1	High	high	JJ
cord-263645-wupre5uj	118	2	-	-	HYPH
cord-263645-wupre5uj	118	3	throughput	throughput	NN
cord-263645-wupre5uj	118	4	and	and	CC
cord-263645-wupre5uj	118	5	focused	focus	VBN
cord-263645-wupre5uj	118	6	computational	computational	JJ
cord-263645-wupre5uj	118	7	screens	screen	NNS
cord-263645-wupre5uj	118	8	were	be	VBD
cord-263645-wupre5uj	118	9	used	use	VBN
cord-263645-wupre5uj	118	10	to	to	TO
cord-263645-wupre5uj	118	11	identify	identify	VB
cord-263645-wupre5uj	118	12	four	four	CD
cord-263645-wupre5uj	118	13	small	small	JJ
cord-263645-wupre5uj	118	14	molecules	molecule	NNS
cord-263645-wupre5uj	118	15	[	[	-LRB-
cord-263645-wupre5uj	118	16	Figure	figure	NN
cord-263645-wupre5uj	118	17	4A	4a	CD
cord-263645-wupre5uj	118	18	]	]	-RRB-
cord-263645-wupre5uj	118	19	.	.	.
cord-263645-wupre5uj	119	1	Two	two	CD
cord-263645-wupre5uj	119	2	small	small	JJ
cord-263645-wupre5uj	119	3	molecules	molecule	NNS
cord-263645-wupre5uj	119	4	were	be	VBD
cord-263645-wupre5uj	119	5	identified	identify	VBN
cord-263645-wupre5uj	119	6	by	by	IN
cord-263645-wupre5uj	119	7	docking	dock	VBG
cord-263645-wupre5uj	119	8	against	against	IN
cord-263645-wupre5uj	119	9	experimentally	experimentally	RB
cord-263645-wupre5uj	119	10	determined	determine	VBN
cord-263645-wupre5uj	119	11	structures	structure	NNS
cord-263645-wupre5uj	119	12	of	of	IN
cord-263645-wupre5uj	119	13	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	119	14	TAR	TAR	NNP
cord-263645-wupre5uj	119	15	(	(	-LRB-
cord-263645-wupre5uj	119	16	54	54	CD
cord-263645-wupre5uj	119	17	)	)	-RRB-
cord-263645-wupre5uj	119	18	and	and	CC
cord-263645-wupre5uj	119	19	RRE	RRE	NNP
cord-263645-wupre5uj	119	20	RNA	RNA	NNP
cord-263645-wupre5uj	119	21	(	(	-LRB-
cord-263645-wupre5uj	119	22	48	48	CD
cord-263645-wupre5uj	119	23	)	)	-RRB-
cord-263645-wupre5uj	119	24	.	.	.
cord-263645-wupre5uj	120	1	In	in	IN
cord-263645-wupre5uj	120	2	another	another	DT
cord-263645-wupre5uj	120	3	example	example	NN
cord-263645-wupre5uj	120	4	,	,	,
cord-263645-wupre5uj	120	5	small	small	JJ
cord-263645-wupre5uj	120	6	molecules	molecule	NNS
cord-263645-wupre5uj	120	7	were	be	VBD
cord-263645-wupre5uj	120	8	modeled	model	VBN
cord-263645-wupre5uj	120	9	into	into	IN
cord-263645-wupre5uj	120	10	an	an	DT
cord-263645-wupre5uj	120	11	X	x	NN
cord-263645-wupre5uj	120	12	-	-	NN
cord-263645-wupre5uj	120	13	ray	ray	NN
cord-263645-wupre5uj	120	14	diffraction	diffraction	NN
cord-263645-wupre5uj	120	15	structure	structure	NN
cord-263645-wupre5uj	120	16	of	of	IN
cord-263645-wupre5uj	120	17	the	the	DT
cord-263645-wupre5uj	120	18	xpt	xpt	NNP
cord-263645-wupre5uj	120	19	-	-	HYPH
cord-263645-wupre5uj	120	20	pbuE	pbue	JJ
cord-263645-wupre5uj	120	21	guanine	guanine	NN
cord-263645-wupre5uj	120	22	riboswitch	riboswitch	NN
cord-263645-wupre5uj	120	23	aptamer	aptamer	JJ
cord-263645-wupre5uj	120	24	after	after	IN
cord-263645-wupre5uj	120	25	the	the	DT
cord-263645-wupre5uj	120	26	native	native	JJ
cord-263645-wupre5uj	120	27	ligand	ligand	NN
cord-263645-wupre5uj	120	28	was	be	VBD
cord-263645-wupre5uj	120	29	removed	remove	VBN
cord-263645-wupre5uj	120	30	(	(	-LRB-
cord-263645-wupre5uj	120	31	46	46	CD
cord-263645-wupre5uj	120	32	)	)	-RRB-
cord-263645-wupre5uj	120	33	.	.	.
cord-263645-wupre5uj	121	1	Criteria	criterion	NNS
cord-263645-wupre5uj	121	2	such	such	JJ
cord-263645-wupre5uj	121	3	as	as	IN
cord-263645-wupre5uj	121	4	geometrical	geometrical	JJ
cord-263645-wupre5uj	121	5	constraints	constraint	NNS
cord-263645-wupre5uj	121	6	,	,	,
cord-263645-wupre5uj	121	7	hydrogen	hydrogen	NN
cord-263645-wupre5uj	121	8	bonding	bonding	NN
cord-263645-wupre5uj	121	9	patterns	pattern	NNS
cord-263645-wupre5uj	121	10	,	,	,
cord-263645-wupre5uj	121	11	and	and	CC
cord-263645-wupre5uj	121	12	molecule	molecule	NN
cord-263645-wupre5uj	121	13	planarity	planarity	NN
cord-263645-wupre5uj	121	14	were	be	VBD
cord-263645-wupre5uj	121	15	used	use	VBN
cord-263645-wupre5uj	121	16	to	to	TO
cord-263645-wupre5uj	121	17	assess	assess	VB
cord-263645-wupre5uj	121	18	the	the	DT
cord-263645-wupre5uj	121	19	'	'	``
cord-263645-wupre5uj	121	20	fit	fit	JJ
cord-263645-wupre5uj	121	21	'	'	''
cord-263645-wupre5uj	121	22	of	of	IN
cord-263645-wupre5uj	121	23	the	the	DT
cord-263645-wupre5uj	121	24	ligand	ligand	NN
cord-263645-wupre5uj	121	25	,	,	,
cord-263645-wupre5uj	121	26	leading	lead	VBG
cord-263645-wupre5uj	121	27	to	to	IN
cord-263645-wupre5uj	121	28	the	the	DT
cord-263645-wupre5uj	121	29	selection	selection	NN
cord-263645-wupre5uj	121	30	of	of	IN
cord-263645-wupre5uj	121	31	two	two	CD
cord-263645-wupre5uj	121	32	small	small	JJ
cord-263645-wupre5uj	121	33	molecules	molecule	NNS
cord-263645-wupre5uj	121	34	,	,	,
cord-263645-wupre5uj	121	35	one	one	CD
cord-263645-wupre5uj	121	36	of	of	IN
cord-263645-wupre5uj	121	37	which	which	WDT
cord-263645-wupre5uj	121	38	had	have	VBD
cord-263645-wupre5uj	121	39	antimicrobial	antimicrobial	JJ
cord-263645-wupre5uj	121	40	activity	activity	NN
cord-263645-wupre5uj	121	41	against	against	IN
cord-263645-wupre5uj	121	42	9	9	CD
cord-263645-wupre5uj	121	43	of	of	IN
cord-263645-wupre5uj	121	44	the	the	DT
cord-263645-wupre5uj	121	45	15	15	CD
cord-263645-wupre5uj	121	46	Gram	gram	NN
cord-263645-wupre5uj	121	47	-	-	HYPH
cord-263645-wupre5uj	121	48	positive	positive	JJ
cord-263645-wupre5uj	121	49	bacteria	bacteria	NNS
cord-263645-wupre5uj	121	50	species	specie	NNS
cord-263645-wupre5uj	121	51	tested	test	VBN
cord-263645-wupre5uj	121	52	and	and	CC
cord-263645-wupre5uj	121	53	was	be	VBD
cord-263645-wupre5uj	121	54	selective	selective	JJ
cord-263645-wupre5uj	121	55	for	for	IN
cord-263645-wupre5uj	121	56	species	specie	NNS
cord-263645-wupre5uj	121	57	with	with	IN
cord-263645-wupre5uj	121	58	the	the	DT
cord-263645-wupre5uj	121	59	guaA	guaa	JJ
cord-263645-wupre5uj	121	60	gene	gene	NN
cord-263645-wupre5uj	121	61	under	under	IN
cord-263645-wupre5uj	121	62	riboswitch	riboswitch	NNP
cord-263645-wupre5uj	121	63	control	control	NN
cord-263645-wupre5uj	121	64	.	.	.
cord-263645-wupre5uj	122	1	The	the	DT
cord-263645-wupre5uj	122	2	fourth	fourth	JJ
cord-263645-wupre5uj	122	3	example	example	NN
cord-263645-wupre5uj	122	4	utilized	utilize	VBD
cord-263645-wupre5uj	122	5	a	a	DT
cord-263645-wupre5uj	122	6	computationally	computationally	RB
cord-263645-wupre5uj	122	7	-	-	HYPH
cord-263645-wupre5uj	122	8	predicted	predict	VBN
cord-263645-wupre5uj	122	9	3D	3d	JJ
cord-263645-wupre5uj	122	10	structure	structure	NN
cord-263645-wupre5uj	122	11	of	of	IN
cord-263645-wupre5uj	122	12	the	the	DT
cord-263645-wupre5uj	122	13	severe	severe	JJ
cord-263645-wupre5uj	122	14	acute	acute	JJ
cord-263645-wupre5uj	122	15	respiratory	respiratory	JJ
cord-263645-wupre5uj	122	16	syndrome	syndrome	NN
cord-263645-wupre5uj	122	17	coronavirus	coronavirus	NN
cord-263645-wupre5uj	122	18	(	(	-LRB-
cord-263645-wupre5uj	122	19	SARS	SARS	NNP
cord-263645-wupre5uj	122	20	-	-	HYPH
cord-263645-wupre5uj	122	21	CoV	CoV	NNP
cord-263645-wupre5uj	122	22	)	)	-RRB-
cord-263645-wupre5uj	122	23	pseudoknot	pseudoknot	NNP
cord-263645-wupre5uj	122	24	(	(	-LRB-
cord-263645-wupre5uj	122	25	55	55	CD
cord-263645-wupre5uj	122	26	)	)	-RRB-
cord-263645-wupre5uj	122	27	.	.	.
cord-263645-wupre5uj	123	1	A	a	DT
cord-263645-wupre5uj	123	2	library	library	NN
cord-263645-wupre5uj	123	3	of	of	IN
cord-263645-wupre5uj	123	4	80	80	CD
cord-263645-wupre5uj	123	5	000	000	CD
cord-263645-wupre5uj	123	6	small	small	JJ
cord-263645-wupre5uj	123	7	molecules	molecule	NNS
cord-263645-wupre5uj	123	8	was	be	VBD
cord-263645-wupre5uj	123	9	docked	dock	VBN
cord-263645-wupre5uj	123	10	against	against	IN
cord-263645-wupre5uj	123	11	the	the	DT
cord-263645-wupre5uj	123	12	predicted	predict	VBN
cord-263645-wupre5uj	123	13	structure	structure	NN
cord-263645-wupre5uj	123	14	,	,	,
cord-263645-wupre5uj	123	15	and	and	CC
cord-263645-wupre5uj	123	16	the	the	DT
cord-263645-wupre5uj	123	17	58	58	CD
cord-263645-wupre5uj	123	18	highest	high	JJS
cord-263645-wupre5uj	123	19	scoring	scoring	NN
cord-263645-wupre5uj	123	20	molecules	molecule	NNS
cord-263645-wupre5uj	123	21	were	be	VBD
cord-263645-wupre5uj	123	22	tested	test	VBN
cord-263645-wupre5uj	123	23	in	in	IN
cord-263645-wupre5uj	123	24	an	an	DT
cord-263645-wupre5uj	123	25	in	in	FW
cord-263645-wupre5uj	123	26	vitro	vitro	FW
cord-263645-wupre5uj	123	27	activity	activity	NN
cord-263645-wupre5uj	123	28	-	-	HYPH
cord-263645-wupre5uj	123	29	based	base	VBN
cord-263645-wupre5uj	123	30	assay	assay	NN
cord-263645-wupre5uj	123	31	.	.	.
cord-263645-wupre5uj	124	1	The	the	DT
cord-263645-wupre5uj	124	2	screen	screen	NN
cord-263645-wupre5uj	124	3	resulted	result	VBD
cord-263645-wupre5uj	124	4	in	in	IN
cord-263645-wupre5uj	124	5	a	a	DT
cord-263645-wupre5uj	124	6	biologically	biologically	RB
cord-263645-wupre5uj	124	7	active	active	JJ
cord-263645-wupre5uj	124	8	ligand	ligand	NN
cord-263645-wupre5uj	124	9	with	with	IN
cord-263645-wupre5uj	124	10	an	an	DT
cord-263645-wupre5uj	124	11	IC	IC	NNP
cord-263645-wupre5uj	124	12	50	50	CD
cord-263645-wupre5uj	124	13	value	value	NN
cord-263645-wupre5uj	124	14	of	of	IN
cord-263645-wupre5uj	124	15	0.45	0.45	CD
cord-263645-wupre5uj	124	16	M	m	NN
cord-263645-wupre5uj	124	17	in	in	IN
cord-263645-wupre5uj	124	18	cell	cell	NN
cord-263645-wupre5uj	124	19	-	-	HYPH
cord-263645-wupre5uj	124	20	based	base	VBN
cord-263645-wupre5uj	124	21	models	model	NNS
cord-263645-wupre5uj	124	22	.	.	.
cord-263645-wupre5uj	125	1	Additional	additional	JJ
cord-263645-wupre5uj	125	2	advances	advance	NNS
cord-263645-wupre5uj	125	3	in	in	IN
cord-263645-wupre5uj	125	4	computational	computational	JJ
cord-263645-wupre5uj	125	5	structural	structural	JJ
cord-263645-wupre5uj	125	6	prediction	prediction	NN
cord-263645-wupre5uj	125	7	and	and	CC
cord-263645-wupre5uj	125	8	RNA	RNA	NNP
cord-263645-wupre5uj	125	9	:	:	:
cord-263645-wupre5uj	125	10	ligand	ligand	NN
cord-263645-wupre5uj	125	11	docking	docking	NN
cord-263645-wupre5uj	125	12	will	will	MD
cord-263645-wupre5uj	125	13	undoubtedly	undoubtedly	RB
cord-263645-wupre5uj	125	14	lead	lead	VB
cord-263645-wupre5uj	125	15	to	to	IN
cord-263645-wupre5uj	125	16	improved	improve	VBN
cord-263645-wupre5uj	125	17	computational	computational	JJ
cord-263645-wupre5uj	125	18	primary	primary	JJ
cord-263645-wupre5uj	125	19	screens	screen	NNS
cord-263645-wupre5uj	125	20	and	and	CC
cord-263645-wupre5uj	125	21	thus	thus	RB
cord-263645-wupre5uj	125	22	more	more	RBR
cord-263645-wupre5uj	125	23	efficient	efficient	JJ
cord-263645-wupre5uj	125	24	experimental	experimental	JJ
cord-263645-wupre5uj	125	25	screens	screen	NNS
cord-263645-wupre5uj	125	26	(	(	-LRB-
cord-263645-wupre5uj	125	27	56	56	CD
cord-263645-wupre5uj	125	28	,	,	,
cord-263645-wupre5uj	125	29	57	57	CD
cord-263645-wupre5uj	125	30	)	)	-RRB-
cord-263645-wupre5uj	125	31	.	.	.
cord-263645-wupre5uj	126	1	In	in	IN
cord-263645-wupre5uj	126	2	addition	addition	NN
cord-263645-wupre5uj	126	3	to	to	IN
cord-263645-wupre5uj	126	4	the	the	DT
cord-263645-wupre5uj	126	5	primary	primary	JJ
cord-263645-wupre5uj	126	6	screens	screen	NNS
cord-263645-wupre5uj	126	7	,	,	,
cord-263645-wupre5uj	126	8	a	a	DT
cord-263645-wupre5uj	126	9	database	database	NN
cord-263645-wupre5uj	126	10	of	of	IN
cord-263645-wupre5uj	126	11	known	know	VBN
cord-263645-wupre5uj	126	12	RNA	RNA	NNP
cord-263645-wupre5uj	126	13	motif	motif	NN
cord-263645-wupre5uj	126	14	:	:	:
cord-263645-wupre5uj	126	15	small	small	JJ
cord-263645-wupre5uj	126	16	molecule	molecule	NN
cord-263645-wupre5uj	126	17	interactions	interaction	NNS
cord-263645-wupre5uj	126	18	,	,	,
cord-263645-wupre5uj	126	19	Inforna	Inforna	NNP
cord-263645-wupre5uj	126	20	(	(	-LRB-
cord-263645-wupre5uj	126	21	39	39	CD
cord-263645-wupre5uj	126	22	)	)	-RRB-
cord-263645-wupre5uj	126	23	,	,	,
cord-263645-wupre5uj	126	24	was	be	VBD
cord-263645-wupre5uj	126	25	utilized	utilize	VBN
cord-263645-wupre5uj	126	26	to	to	TO
cord-263645-wupre5uj	126	27	identify	identify	VB
cord-263645-wupre5uj	126	28	seven	seven	CD
cord-263645-wupre5uj	126	29	small	small	JJ
cord-263645-wupre5uj	126	30	molecules	molecule	NNS
cord-263645-wupre5uj	126	31	.	.	.
cord-263645-wupre5uj	127	1	The	the	DT
cord-263645-wupre5uj	127	2	database	database	NN
cord-263645-wupre5uj	127	3	was	be	VBD
cord-263645-wupre5uj	127	4	generated	generate	VBN
cord-263645-wupre5uj	127	5	using	use	VBG
cord-263645-wupre5uj	127	6	a	a	DT
cord-263645-wupre5uj	127	7	library	library	NN
cord-263645-wupre5uj	127	8	versus	versus	IN
cord-263645-wupre5uj	127	9	library	library	NN
cord-263645-wupre5uj	127	10	approach	approach	NN
cord-263645-wupre5uj	127	11	named	name	VBD
cord-263645-wupre5uj	127	12	2-Dimensional	2-dimensional	CD
cord-263645-wupre5uj	127	13	Combinatorial	Combinatorial	NNP
cord-263645-wupre5uj	127	14	Screening	Screening	NNP
cord-263645-wupre5uj	127	15	(	(	-LRB-
cord-263645-wupre5uj	127	16	2DCS	2dcs	CD
cord-263645-wupre5uj	127	17	)	)	-RRB-
cord-263645-wupre5uj	127	18	.	.	.
cord-263645-wupre5uj	128	1	In	in	IN
cord-263645-wupre5uj	128	2	this	this	DT
cord-263645-wupre5uj	128	3	method	method	NN
cord-263645-wupre5uj	128	4	,	,	,
cord-263645-wupre5uj	128	5	small	small	JJ
cord-263645-wupre5uj	128	6	molecules	molecule	NNS
cord-263645-wupre5uj	128	7	are	be	VBP
cord-263645-wupre5uj	128	8	immobilized	immobilize	VBN
cord-263645-wupre5uj	128	9	onto	onto	IN
cord-263645-wupre5uj	128	10	a	a	DT
cord-263645-wupre5uj	128	11	microarray	microarray	NN
cord-263645-wupre5uj	128	12	slide	slide	NN
cord-263645-wupre5uj	128	13	and	and	CC
cord-263645-wupre5uj	128	14	then	then	RB
cord-263645-wupre5uj	128	15	incubated	incubate	VBN
cord-263645-wupre5uj	128	16	with	with	IN
cord-263645-wupre5uj	128	17	libraries	library	NNS
cord-263645-wupre5uj	128	18	of	of	IN
cord-263645-wupre5uj	128	19	labeled	label	VBN
cord-263645-wupre5uj	128	20	,	,	,
cord-263645-wupre5uj	128	21	randomized	randomized	JJ
cord-263645-wupre5uj	128	22	RNA	RNA	NNP
cord-263645-wupre5uj	128	23	secondary	secondary	JJ
cord-263645-wupre5uj	128	24	structures	structure	NNS
cord-263645-wupre5uj	128	25	.	.	.
cord-263645-wupre5uj	129	1	The	the	DT
cord-263645-wupre5uj	129	2	bound	bound	JJ
cord-263645-wupre5uj	129	3	RNAs	rna	NNS
cord-263645-wupre5uj	129	4	are	be	VBP
cord-263645-wupre5uj	129	5	excised	excise	VBN
cord-263645-wupre5uj	129	6	,	,	,
cord-263645-wupre5uj	129	7	sequenced	sequence	VBN
cord-263645-wupre5uj	129	8	,	,	,
cord-263645-wupre5uj	129	9	and	and	CC
cord-263645-wupre5uj	129	10	assigned	assign	VBD
cord-263645-wupre5uj	129	11	a	a	DT
cord-263645-wupre5uj	129	12	fitness	fitness	NN
cord-263645-wupre5uj	129	13	score	score	NN
cord-263645-wupre5uj	129	14	using	use	VBG
cord-263645-wupre5uj	129	15	Structure	Structure	NNP
cord-263645-wupre5uj	129	16	-	-	HYPH
cord-263645-wupre5uj	129	17	Activity	Activity	NNP
cord-263645-wupre5uj	129	18	Relationships	relationship	NNS
cord-263645-wupre5uj	129	19	Through	through	IN
cord-263645-wupre5uj	129	20	Sequencing	sequencing	NN
cord-263645-wupre5uj	129	21	(	(	-LRB-
cord-263645-wupre5uj	129	22	StARTS	StARTS	NNP
cord-263645-wupre5uj	129	23	)	)	-RRB-
cord-263645-wupre5uj	129	24	.	.	.
cord-263645-wupre5uj	130	1	Fitness	fitness	NN
cord-263645-wupre5uj	130	2	scores	score	NNS
cord-263645-wupre5uj	130	3	reflect	reflect	VBP
cord-263645-wupre5uj	130	4	the	the	DT
cord-263645-wupre5uj	130	5	affinity	affinity	NN
cord-263645-wupre5uj	130	6	and	and	CC
cord-263645-wupre5uj	130	7	selectivity	selectivity	NN
cord-263645-wupre5uj	130	8	of	of	IN
cord-263645-wupre5uj	130	9	a	a	DT
cord-263645-wupre5uj	130	10	given	give	VBN
cord-263645-wupre5uj	130	11	RNA	rna	NN
cord-263645-wupre5uj	130	12	motif	motif	NN
cord-263645-wupre5uj	130	13	:	:	:
cord-263645-wupre5uj	130	14	small	small	JJ
cord-263645-wupre5uj	130	15	molecule	molecule	NN
cord-263645-wupre5uj	130	16	interaction	interaction	NN
cord-263645-wupre5uj	130	17	and	and	CC
cord-263645-wupre5uj	130	18	are	be	VBP
cord-263645-wupre5uj	130	19	represented	represent	VBN
cord-263645-wupre5uj	130	20	on	on	IN
cord-263645-wupre5uj	130	21	a	a	DT
cord-263645-wupre5uj	130	22	numerical	numerical	JJ
cord-263645-wupre5uj	130	23	scale	scale	NN
cord-263645-wupre5uj	130	24	,	,	,
cord-263645-wupre5uj	130	25	where	where	WRB
cord-263645-wupre5uj	130	26	a	a	DT
cord-263645-wupre5uj	130	27	higher	high	JJR
cord-263645-wupre5uj	130	28	score	score	NN
cord-263645-wupre5uj	130	29	represents	represent	VBZ
cord-263645-wupre5uj	130	30	greater	great	JJR
cord-263645-wupre5uj	130	31	selectivity	selectivity	NN
cord-263645-wupre5uj	130	32	.	.	.
cord-263645-wupre5uj	131	1	To	to	TO
cord-263645-wupre5uj	131	2	utilize	utilize	VB
cord-263645-wupre5uj	131	3	the	the	DT
cord-263645-wupre5uj	131	4	Inforna	Inforna	NNP
cord-263645-wupre5uj	131	5	database	database	NN
cord-263645-wupre5uj	131	6	,	,	,
cord-263645-wupre5uj	131	7	a	a	DT
cord-263645-wupre5uj	131	8	computational	computational	JJ
cord-263645-wupre5uj	131	9	or	or	CC
cord-263645-wupre5uj	131	10	experimental	experimental	JJ
cord-263645-wupre5uj	131	11	secondary	secondary	JJ
cord-263645-wupre5uj	131	12	structure	structure	NN
cord-263645-wupre5uj	131	13	of	of	IN
cord-263645-wupre5uj	131	14	RNA	RNA	NNP
cord-263645-wupre5uj	131	15	is	be	VBZ
cord-263645-wupre5uj	131	16	input	input	NN
cord-263645-wupre5uj	131	17	,	,	,
cord-263645-wupre5uj	131	18	the	the	DT
cord-263645-wupre5uj	131	19	2DCS	2dcs	CD
cord-263645-wupre5uj	131	20	data	datum	NNS
cord-263645-wupre5uj	131	21	is	be	VBZ
cord-263645-wupre5uj	131	22	searched	search	VBN
cord-263645-wupre5uj	131	23	and	and	CC
cord-263645-wupre5uj	131	24	lead	lead	JJ
cord-263645-wupre5uj	131	25	molecules	molecule	NNS
cord-263645-wupre5uj	131	26	are	be	VBP
cord-263645-wupre5uj	131	27	proposed	propose	VBN
cord-263645-wupre5uj	131	28	.	.	.
cord-263645-wupre5uj	132	1	This	this	DT
cord-263645-wupre5uj	132	2	strategy	strategy	NN
cord-263645-wupre5uj	132	3	identified	identify	VBD
cord-263645-wupre5uj	132	4	bioactive	bioactive	JJ
cord-263645-wupre5uj	132	5	ligands	ligand	NNS
cord-263645-wupre5uj	132	6	for	for	IN
cord-263645-wupre5uj	132	7	five	five	CD
cord-263645-wupre5uj	132	8	targets	target	NNS
cord-263645-wupre5uj	132	9	:	:	:
cord-263645-wupre5uj	132	10	(	(	-LRB-
cord-263645-wupre5uj	132	11	i	i	NN
cord-263645-wupre5uj	132	12	)	)	-RRB-
cord-263645-wupre5uj	133	1	MAPT	MAPT	NNP
cord-263645-wupre5uj	133	2	pre	pre	NNP
cord-263645-wupre5uj	133	3	-	-	NNP
cord-263645-wupre5uj	133	4	mRNA	mrna	NN
cord-263645-wupre5uj	133	5	,	,	,
cord-263645-wupre5uj	133	6	1-nucleotide	1-nucleotide	CD
cord-263645-wupre5uj	133	7	bulge	bulge	NN
cord-263645-wupre5uj	133	8	;	;	,
cord-263645-wupre5uj	133	9	(	(	-LRB-
cord-263645-wupre5uj	133	10	58	58	CD
cord-263645-wupre5uj	133	11	)	)	-RRB-
cord-263645-wupre5uj	134	1	(	(	-LRB-
cord-263645-wupre5uj	134	2	ii	ii	NN
cord-263645-wupre5uj	134	3	)	)	-RRB-
cord-263645-wupre5uj	135	1	Pre	Pre	NNP
cord-263645-wupre5uj	135	2	-	-	NNP
cord-263645-wupre5uj	135	3	miRNA-96	miRNA-96	NNP
cord-263645-wupre5uj	135	4	,	,	,
cord-263645-wupre5uj	135	5	1	1	CD
cord-263645-wupre5uj	135	6	×	×	NN
cord-263645-wupre5uj	135	7	1	1	CD
cord-263645-wupre5uj	135	8	internal	internal	JJ
cord-263645-wupre5uj	135	9	loop	loop	NN
cord-263645-wupre5uj	135	10	(	(	-LRB-
cord-263645-wupre5uj	135	11	59	59	CD
cord-263645-wupre5uj	135	12	)	)	-RRB-
cord-263645-wupre5uj	135	13	;	;	:
cord-263645-wupre5uj	135	14	(	(	-LRB-
cord-263645-wupre5uj	135	15	iii	iii	NN
cord-263645-wupre5uj	135	16	)	)	-RRB-
cord-263645-wupre5uj	136	1	Pre	Pre	NNP
cord-263645-wupre5uj	136	2	-	-	NN
cord-263645-wupre5uj	136	3	miRNA-18a	miRNA-18a	NNP
cord-263645-wupre5uj	136	4	,	,	,
cord-263645-wupre5uj	136	5	1-nucleotide	1-nucleotide	CD
cord-263645-wupre5uj	136	6	bulge	bulge	NN
cord-263645-wupre5uj	136	7	(	(	-LRB-
cord-263645-wupre5uj	136	8	60	60	CD
cord-263645-wupre5uj	136	9	)	)	-RRB-
cord-263645-wupre5uj	136	10	;	;	:
cord-263645-wupre5uj	136	11	(	(	-LRB-
cord-263645-wupre5uj	136	12	iv	iv	LS
cord-263645-wupre5uj	136	13	)	)	-RRB-
cord-263645-wupre5uj	137	1	Pre	pre	JJ
cord-263645-wupre5uj	137	2	-	-	JJ
cord-263645-wupre5uj	137	3	miRNA-210	mirna-210	JJ
cord-263645-wupre5uj	137	4	,	,	,
cord-263645-wupre5uj	137	5	1	1	CD
cord-263645-wupre5uj	137	6	×	×	NN
cord-263645-wupre5uj	137	7	1	1	CD
cord-263645-wupre5uj	137	8	internal	internal	JJ
cord-263645-wupre5uj	137	9	loop	loop	NN
cord-263645-wupre5uj	137	10	(	(	-LRB-
cord-263645-wupre5uj	137	11	16	16	CD
cord-263645-wupre5uj	137	12	)	)	-RRB-
cord-263645-wupre5uj	137	13	and	and	CC
cord-263645-wupre5uj	137	14	(	(	-LRB-
cord-263645-wupre5uj	137	15	v	v	LS
cord-263645-wupre5uj	137	16	)	)	-RRB-
cord-263645-wupre5uj	137	17	Pre	pre	NN
cord-263645-wupre5uj	137	18	-	-	JJ
cord-263645-wupre5uj	137	19	miRNA-544	mirna-544	JJ
cord-263645-wupre5uj	137	20	,	,	,
cord-263645-wupre5uj	137	21	1	1	CD
cord-263645-wupre5uj	137	22	×	×	NN
cord-263645-wupre5uj	137	23	1	1	CD
cord-263645-wupre5uj	137	24	internal	internal	JJ
cord-263645-wupre5uj	137	25	loop	loop	NN
cord-263645-wupre5uj	137	26	(	(	-LRB-
cord-263645-wupre5uj	137	27	61	61	CD
cord-263645-wupre5uj	137	28	)	)	-RRB-
cord-263645-wupre5uj	137	29	.	.	.
cord-263645-wupre5uj	138	1	Other	other	JJ
cord-263645-wupre5uj	138	2	examples	example	NNS
cord-263645-wupre5uj	138	3	of	of	IN
cord-263645-wupre5uj	138	4	ligands	ligand	NNS
cord-263645-wupre5uj	138	5	not	not	RB
cord-263645-wupre5uj	138	6	identified	identify	VBN
cord-263645-wupre5uj	138	7	from	from	IN
cord-263645-wupre5uj	138	8	a	a	DT
cord-263645-wupre5uj	138	9	primary	primary	JJ
cord-263645-wupre5uj	138	10	screening	screening	NN
cord-263645-wupre5uj	138	11	assay	assay	NN
cord-263645-wupre5uj	138	12	included	include	VBD
cord-263645-wupre5uj	138	13	the	the	DT
cord-263645-wupre5uj	138	14	selection	selection	NN
cord-263645-wupre5uj	138	15	and	and	CC
cord-263645-wupre5uj	138	16	characterization	characterization	NN
cord-263645-wupre5uj	138	17	of	of	IN
cord-263645-wupre5uj	138	18	four	four	CD
cord-263645-wupre5uj	138	19	metabolite	metabolite	JJ
cord-263645-wupre5uj	138	20	analogs	analog	NNS
cord-263645-wupre5uj	138	21	for	for	IN
cord-263645-wupre5uj	138	22	riboswitch	riboswitch	NN
cord-263645-wupre5uj	138	23	inhibition	inhibition	NN
cord-263645-wupre5uj	138	24	(	(	-LRB-
cord-263645-wupre5uj	138	25	62	62	CD
cord-263645-wupre5uj	138	26	)	)	-RRB-
cord-263645-wupre5uj	138	27	(	(	-LRB-
cord-263645-wupre5uj	138	28	63	63	CD
cord-263645-wupre5uj	138	29	)	)	-RRB-
cord-263645-wupre5uj	138	30	(	(	-LRB-
cord-263645-wupre5uj	138	31	64	64	CD
cord-263645-wupre5uj	138	32	)	)	-RRB-
cord-263645-wupre5uj	138	33	(	(	-LRB-
cord-263645-wupre5uj	138	34	65	65	CD
cord-263645-wupre5uj	138	35	)	)	-RRB-
cord-263645-wupre5uj	138	36	.	.	.
cord-263645-wupre5uj	139	1	In	in	IN
cord-263645-wupre5uj	139	2	contrast	contrast	NN
cord-263645-wupre5uj	139	3	to	to	IN
cord-263645-wupre5uj	139	4	small	small	JJ
cord-263645-wupre5uj	139	5	molecules	molecule	NNS
cord-263645-wupre5uj	139	6	,	,	,
cord-263645-wupre5uj	139	7	most	most	RBS
cord-263645-wupre5uj	139	8	multivalent	multivalent	JJ
cord-263645-wupre5uj	139	9	ligands	ligand	NNS
cord-263645-wupre5uj	139	10	were	be	VBD
cord-263645-wupre5uj	139	11	developed	develop	VBN
cord-263645-wupre5uj	139	12	through	through	IN
cord-263645-wupre5uj	139	13	rational	rational	JJ
cord-263645-wupre5uj	139	14	design	design	NN
cord-263645-wupre5uj	139	15	based	base	VBN
cord-263645-wupre5uj	139	16	on	on	IN
cord-263645-wupre5uj	139	17	the	the	DT
cord-263645-wupre5uj	139	18	secondary	secondary	JJ
cord-263645-wupre5uj	139	19	structure	structure	NN
cord-263645-wupre5uj	139	20	of	of	IN
cord-263645-wupre5uj	139	21	the	the	DT
cord-263645-wupre5uj	139	22	RNA	RNA	NNP
cord-263645-wupre5uj	139	23	target	target	NN
cord-263645-wupre5uj	139	24	[	[	-LRB-
cord-263645-wupre5uj	139	25	Figure	figure	NN
cord-263645-wupre5uj	139	26	5A	5a	NN
cord-263645-wupre5uj	139	27	]	]	-RRB-
cord-263645-wupre5uj	139	28	.	.	.
cord-263645-wupre5uj	140	1	Generally	generally	RB
cord-263645-wupre5uj	140	2	,	,	,
cord-263645-wupre5uj	140	3	development	development	NN
cord-263645-wupre5uj	140	4	began	begin	VBD
cord-263645-wupre5uj	140	5	by	by	IN
cord-263645-wupre5uj	140	6	the	the	DT
cord-263645-wupre5uj	140	7	identification	identification	NN
cord-263645-wupre5uj	140	8	of	of	IN
cord-263645-wupre5uj	140	9	monovalent	monovalent	JJ
cord-263645-wupre5uj	140	10	ligands	ligand	NNS
cord-263645-wupre5uj	140	11	that	that	WDT
cord-263645-wupre5uj	140	12	bound	bind	VBD
cord-263645-wupre5uj	140	13	to	to	IN
cord-263645-wupre5uj	140	14	a	a	DT
cord-263645-wupre5uj	140	15	particular	particular	JJ
cord-263645-wupre5uj	140	16	secondary	secondary	JJ
cord-263645-wupre5uj	140	17	structure	structure	NN
cord-263645-wupre5uj	140	18	motif(s	motif(s	NNP
cord-263645-wupre5uj	140	19	)	)	-RRB-
cord-263645-wupre5uj	140	20	by	by	IN
cord-263645-wupre5uj	140	21	screening	screening	NN
cord-263645-wupre5uj	140	22	,	,	,
cord-263645-wupre5uj	140	23	literature	literature	NN
cord-263645-wupre5uj	140	24	search	search	NN
cord-263645-wupre5uj	140	25	,	,	,
cord-263645-wupre5uj	140	26	or	or	CC
cord-263645-wupre5uj	140	27	using	use	VBG
cord-263645-wupre5uj	140	28	Inforna	Inforna	NNP
cord-263645-wupre5uj	140	29	[	[	-LRB-
cord-263645-wupre5uj	140	30	See	see	VB
cord-263645-wupre5uj	140	31	section	section	NN
cord-263645-wupre5uj	140	32	'	'	``
cord-263645-wupre5uj	140	33	Other	other	JJ
cord-263645-wupre5uj	140	34	Methods	method	NNS
cord-263645-wupre5uj	140	35	of	of	IN
cord-263645-wupre5uj	140	36	Small	Small	NNP
cord-263645-wupre5uj	140	37	Molecule	Molecule	NNP
cord-263645-wupre5uj	140	38	Discovery	Discovery	NNP
cord-263645-wupre5uj	140	39	'	'	''
cord-263645-wupre5uj	140	40	]	]	-RRB-
cord-263645-wupre5uj	140	41	.	.	.
cord-263645-wupre5uj	141	1	Monomers	monomer	NNS
cord-263645-wupre5uj	141	2	were	be	VBD
cord-263645-wupre5uj	141	3	covalently	covalently	RB
cord-263645-wupre5uj	141	4	linked	link	VBN
cord-263645-wupre5uj	141	5	by	by	IN
cord-263645-wupre5uj	141	6	selecting	select	VBG
cord-263645-wupre5uj	141	7	and	and	CC
cord-263645-wupre5uj	141	8	optimizing	optimize	VBG
cord-263645-wupre5uj	141	9	appropriate	appropriate	JJ
cord-263645-wupre5uj	141	10	sized	sized	JJ
cord-263645-wupre5uj	141	11	spacers	spacer	NNS
cord-263645-wupre5uj	141	12	.	.	.
cord-263645-wupre5uj	142	1	For	for	IN
cord-263645-wupre5uj	142	2	several	several	JJ
cord-263645-wupre5uj	142	3	multivalent	multivalent	JJ
cord-263645-wupre5uj	142	4	ligands	ligand	NNS
cord-263645-wupre5uj	142	5	,	,	,
cord-263645-wupre5uj	142	6	the	the	DT
cord-263645-wupre5uj	142	7	design	design	NN
cord-263645-wupre5uj	142	8	was	be	VBD
cord-263645-wupre5uj	142	9	inspired	inspire	VBN
cord-263645-wupre5uj	142	10	by	by	IN
cord-263645-wupre5uj	142	11	a	a	DT
cord-263645-wupre5uj	142	12	crystal	crystal	JJ
cord-263645-wupre5uj	142	13	structure	structure	NN
cord-263645-wupre5uj	142	14	of	of	IN
cord-263645-wupre5uj	142	15	r(CUG	r(cug	CD
cord-263645-wupre5uj	142	16	)	)	-RRB-
cord-263645-wupre5uj	142	17	sequences	sequence	NNS
cord-263645-wupre5uj	142	18	,	,	,
cord-263645-wupre5uj	142	19	leading	lead	VBG
cord-263645-wupre5uj	142	20	to	to	IN
cord-263645-wupre5uj	142	21	ligands	ligand	NNS
cord-263645-wupre5uj	142	22	targeting	target	VBG
cord-263645-wupre5uj	142	23	r(CUG	r(cug	CD
cord-263645-wupre5uj	142	24	)	)	-RRB-
cord-263645-wupre5uj	142	25	exp	exp	NN
cord-263645-wupre5uj	142	26	in	in	IN
cord-263645-wupre5uj	142	27	Drosophila	drosophila	JJ
cord-263645-wupre5uj	142	28	melanogaster	melanogaster	NN
cord-263645-wupre5uj	142	29	models	model	NNS
cord-263645-wupre5uj	142	30	(	(	-LRB-
cord-263645-wupre5uj	142	31	66	66	CD
cord-263645-wupre5uj	142	32	)	)	-RRB-
cord-263645-wupre5uj	142	33	.	.	.
cord-263645-wupre5uj	143	1	This	this	DT
cord-263645-wupre5uj	143	2	approach	approach	NN
cord-263645-wupre5uj	143	3	linked	link	VBD
cord-263645-wupre5uj	143	4	acridine	acridine	NN
cord-263645-wupre5uj	143	5	and	and	CC
cord-263645-wupre5uj	143	6	a	a	DT
cord-263645-wupre5uj	143	7	triaminotriazine	triaminotriazine	NN
cord-263645-wupre5uj	143	8	unit	unit	NN
cord-263645-wupre5uj	143	9	,	,	,
cord-263645-wupre5uj	143	10	the	the	DT
cord-263645-wupre5uj	143	11	latter	latter	JJ
cord-263645-wupre5uj	143	12	of	of	IN
cord-263645-wupre5uj	143	13	which	which	WDT
cord-263645-wupre5uj	143	14	was	be	VBD
cord-263645-wupre5uj	143	15	proposed	propose	VBN
cord-263645-wupre5uj	143	16	to	to	TO
cord-263645-wupre5uj	143	17	recognize	recognize	VB
cord-263645-wupre5uj	143	18	the	the	DT
cord-263645-wupre5uj	143	19	non	non	JJ
cord-263645-wupre5uj	143	20	-	-	JJ
cord-263645-wupre5uj	143	21	optimal	optimal	JJ
cord-263645-wupre5uj	143	22	base	base	NN
cord-263645-wupre5uj	143	23	pairing	pairing	NN
cord-263645-wupre5uj	143	24	of	of	IN
cord-263645-wupre5uj	143	25	U	U	NNP
cord-263645-wupre5uj	143	26	-	-	HYPH
cord-263645-wupre5uj	143	27	U	u	NN
cord-263645-wupre5uj	143	28	mismatches	mismatch	NNS
cord-263645-wupre5uj	143	29	by	by	IN
cord-263645-wupre5uj	143	30	Janus	Janus	NNP
cord-263645-wupre5uj	143	31	-	-	HYPH
cord-263645-wupre5uj	143	32	wedge	wedge	NN
cord-263645-wupre5uj	143	33	hydrogen	hydrogen	NN
cord-263645-wupre5uj	143	34	bonding	bonding	NN
cord-263645-wupre5uj	143	35	.	.	.
cord-263645-wupre5uj	144	1	Stacking	stack	VBG
cord-263645-wupre5uj	144	2	of	of	IN
cord-263645-wupre5uj	144	3	the	the	DT
cord-263645-wupre5uj	144	4	two	two	CD
cord-263645-wupre5uj	144	5	units	unit	NNS
cord-263645-wupre5uj	144	6	was	be	VBD
cord-263645-wupre5uj	144	7	expected	expect	VBN
cord-263645-wupre5uj	144	8	to	to	TO
cord-263645-wupre5uj	144	9	decrease	decrease	VB
cord-263645-wupre5uj	144	10	nonspecific	nonspecific	JJ
cord-263645-wupre5uj	144	11	intercalative	intercalative	JJ
cord-263645-wupre5uj	144	12	binding	binding	NN
cord-263645-wupre5uj	144	13	.	.	.
cord-263645-wupre5uj	145	1	This	this	DT
cord-263645-wupre5uj	145	2	early	early	JJ
cord-263645-wupre5uj	145	3	design	design	NN
cord-263645-wupre5uj	145	4	was	be	VBD
cord-263645-wupre5uj	145	5	optimized	optimize	VBN
cord-263645-wupre5uj	145	6	to	to	TO
cord-263645-wupre5uj	145	7	yield	yield	VB
cord-263645-wupre5uj	145	8	bisamidinium	bisamidinium	NNP
cord-263645-wupre5uj	145	9	conjugates	conjugate	NNS
cord-263645-wupre5uj	145	10	that	that	WDT
cord-263645-wupre5uj	145	11	mitigated	mitigate	VBD
cord-263645-wupre5uj	145	12	the	the	DT
cord-263645-wupre5uj	145	13	glossy	glossy	JJ
cord-263645-wupre5uj	145	14	and	and	CC
cord-263645-wupre5uj	145	15	rough	rough	JJ
cord-263645-wupre5uj	145	16	eye	eye	NN
cord-263645-wupre5uj	145	17	phenotype	phenotype	NN
cord-263645-wupre5uj	145	18	observed	observe	VBN
cord-263645-wupre5uj	145	19	in	in	IN
cord-263645-wupre5uj	145	20	a	a	DT
cord-263645-wupre5uj	145	21	DM1	dm1	NN
cord-263645-wupre5uj	145	22	transgenic	transgenic	JJ
cord-263645-wupre5uj	145	23	Drosophila	Drosophila	NNP
cord-263645-wupre5uj	145	24	melanogaster	melanogaster	NN
cord-263645-wupre5uj	145	25	model	model	NN
cord-263645-wupre5uj	145	26	(	(	-LRB-
cord-263645-wupre5uj	145	27	67	67	CD
cord-263645-wupre5uj	145	28	)	)	-RRB-
cord-263645-wupre5uj	145	29	.	.	.
cord-263645-wupre5uj	146	1	A	a	DT
cord-263645-wupre5uj	146	2	different	different	JJ
cord-263645-wupre5uj	146	3	approach	approach	NN
cord-263645-wupre5uj	146	4	utilized	utilize	VBN
cord-263645-wupre5uj	146	5	Hoechst	Hoechst	NNP
cord-263645-wupre5uj	146	6	33258	33258	CD
cord-263645-wupre5uj	146	7	,	,	,
cord-263645-wupre5uj	146	8	which	which	WDT
cord-263645-wupre5uj	146	9	had	have	VBD
cord-263645-wupre5uj	146	10	been	be	VBN
cord-263645-wupre5uj	146	11	previously	previously	RB
cord-263645-wupre5uj	146	12	reported	report	VBN
cord-263645-wupre5uj	146	13	to	to	TO
cord-263645-wupre5uj	146	14	bind	bind	VB
cord-263645-wupre5uj	146	15	a	a	DT
cord-263645-wupre5uj	146	16	5	5	CD
cord-263645-wupre5uj	146	17	CUG/3	CUG/3	NNP
cord-263645-wupre5uj	146	18	GUC	GUC	NNP
cord-263645-wupre5uj	146	19	internal	internal	JJ
cord-263645-wupre5uj	146	20	loop	loop	NN
cord-263645-wupre5uj	146	21	(	(	-LRB-
cord-263645-wupre5uj	146	22	68	68	CD
cord-263645-wupre5uj	146	23	)	)	-RRB-
cord-263645-wupre5uj	146	24	.	.	.
cord-263645-wupre5uj	147	1	Hoechst	Hoechst	NNP
cord-263645-wupre5uj	147	2	33258	33258	CD
cord-263645-wupre5uj	147	3	was	be	VBD
cord-263645-wupre5uj	147	4	modified	modify	VBN
cord-263645-wupre5uj	147	5	to	to	TO
cord-263645-wupre5uj	147	6	contain	contain	VB
cord-263645-wupre5uj	147	7	an	an	DT
cord-263645-wupre5uj	147	8	azide	azide	NN
cord-263645-wupre5uj	147	9	handle	handle	NN
cord-263645-wupre5uj	147	10	and	and	CC
cord-263645-wupre5uj	147	11	then	then	RB
cord-263645-wupre5uj	147	12	covalently	covalently	RB
cord-263645-wupre5uj	147	13	linked	link	VBN
cord-263645-wupre5uj	147	14	to	to	IN
cord-263645-wupre5uj	147	15	a	a	DT
cord-263645-wupre5uj	147	16	peptoid	peptoid	NN
cord-263645-wupre5uj	147	17	backbone	backbone	NN
cord-263645-wupre5uj	147	18	via	via	IN
cord-263645-wupre5uj	147	19	click	click	NN
cord-263645-wupre5uj	147	20	chemistry	chemistry	NN
cord-263645-wupre5uj	147	21	(	(	-LRB-
cord-263645-wupre5uj	147	22	21	21	CD
cord-263645-wupre5uj	147	23	)	)	-RRB-
cord-263645-wupre5uj	147	24	.	.	.
cord-263645-wupre5uj	148	1	After	after	IN
cord-263645-wupre5uj	148	2	extensive	extensive	JJ
cord-263645-wupre5uj	148	3	linker	linker	NN
cord-263645-wupre5uj	148	4	optimization	optimization	NN
cord-263645-wupre5uj	148	5	,	,	,
cord-263645-wupre5uj	148	6	multivalent	multivalent	JJ
cord-263645-wupre5uj	148	7	ligands	ligand	NNS
cord-263645-wupre5uj	148	8	were	be	VBD
cord-263645-wupre5uj	148	9	identified	identify	VBN
cord-263645-wupre5uj	148	10	that	that	IN
cord-263645-wupre5uj	148	11	improved	improve	VBN
cord-263645-wupre5uj	148	12	r(CUG	r(cug	CD
cord-263645-wupre5uj	148	13	)	)	-RRB-
cord-263645-wupre5uj	148	14	exprelated	exprelate	VBN
cord-263645-wupre5uj	148	15	splicing	splicing	NN
cord-263645-wupre5uj	148	16	defects	defect	NNS
cord-263645-wupre5uj	148	17	in	in	IN
cord-263645-wupre5uj	148	18	a	a	DT
cord-263645-wupre5uj	148	19	mouse	mouse	NN
cord-263645-wupre5uj	148	20	model	model	NN
cord-263645-wupre5uj	148	21	of	of	IN
cord-263645-wupre5uj	148	22	DM1	DM1	NNP
cord-263645-wupre5uj	148	23	.	.	.
cord-263645-wupre5uj	149	1	One	one	CD
cord-263645-wupre5uj	149	2	notable	notable	JJ
cord-263645-wupre5uj	149	3	exception	exception	NN
cord-263645-wupre5uj	149	4	to	to	IN
cord-263645-wupre5uj	149	5	the	the	DT
cord-263645-wupre5uj	149	6	aforementioned	aforementioned	JJ
cord-263645-wupre5uj	149	7	design	design	NN
cord-263645-wupre5uj	149	8	strategies	strategy	NNS
cord-263645-wupre5uj	149	9	is	be	VBZ
cord-263645-wupre5uj	149	10	the	the	DT
cord-263645-wupre5uj	149	11	use	use	NN
cord-263645-wupre5uj	149	12	of	of	IN
cord-263645-wupre5uj	149	13	dynamic	dynamic	JJ
cord-263645-wupre5uj	149	14	combinatorial	combinatorial	JJ
cord-263645-wupre5uj	149	15	chemistry	chemistry	NN
cord-263645-wupre5uj	149	16	(	(	-LRB-
cord-263645-wupre5uj	149	17	DCC	DCC	NNP
cord-263645-wupre5uj	149	18	)	)	-RRB-
cord-263645-wupre5uj	150	1	[	[	-LRB-
cord-263645-wupre5uj	150	2	Figure	figure	NN
cord-263645-wupre5uj	150	3	5B	5b	NN
cord-263645-wupre5uj	150	4	]	]	-RRB-
cord-263645-wupre5uj	150	5	(	(	-LRB-
cord-263645-wupre5uj	150	6	69	69	CD
cord-263645-wupre5uj	150	7	)	)	-RRB-
cord-263645-wupre5uj	150	8	.	.	.
cord-263645-wupre5uj	151	1	Several	several	JJ
cord-263645-wupre5uj	151	2	multivalent	multivalent	JJ
cord-263645-wupre5uj	151	3	ligands	ligand	NNS
cord-263645-wupre5uj	151	4	were	be	VBD
cord-263645-wupre5uj	151	5	derived	derive	VBN
cord-263645-wupre5uj	151	6	from	from	IN
cord-263645-wupre5uj	151	7	a	a	DT
cord-263645-wupre5uj	151	8	library	library	NN
cord-263645-wupre5uj	151	9	of	of	IN
cord-263645-wupre5uj	151	10	resin	resin	NN
cord-263645-wupre5uj	151	11	-	-	HYPH
cord-263645-wupre5uj	151	12	bound	bind	VBN
cord-263645-wupre5uj	151	13	,	,	,
cord-263645-wupre5uj	151	14	cysteine	cysteine	NN
cord-263645-wupre5uj	151	15	-	-	HYPH
cord-263645-wupre5uj	151	16	containing	contain	VBG
cord-263645-wupre5uj	151	17	monomers	monomer	NNS
cord-263645-wupre5uj	151	18	,	,	,
cord-263645-wupre5uj	151	19	which	which	WDT
cord-263645-wupre5uj	151	20	were	be	VBD
cord-263645-wupre5uj	151	21	allowed	allow	VBN
cord-263645-wupre5uj	151	22	to	to	TO
cord-263645-wupre5uj	151	23	incubate	incubate	VB
cord-263645-wupre5uj	151	24	with	with	IN
cord-263645-wupre5uj	151	25	the	the	DT
cord-263645-wupre5uj	151	26	RNA	RNA	NNP
cord-263645-wupre5uj	151	27	of	of	IN
cord-263645-wupre5uj	151	28	interest	interest	NN
cord-263645-wupre5uj	151	29	,	,	,
cord-263645-wupre5uj	151	30	probing	probe	VBG
cord-263645-wupre5uj	151	31	thousands	thousand	NNS
cord-263645-wupre5uj	151	32	of	of	IN
cord-263645-wupre5uj	151	33	multivalent	multivalent	JJ
cord-263645-wupre5uj	151	34	ligand	ligand	NN
cord-263645-wupre5uj	151	35	combinations	combination	NNS
cord-263645-wupre5uj	151	36	by	by	IN
cord-263645-wupre5uj	151	37	forming	form	VBG
cord-263645-wupre5uj	151	38	covalent	covalent	JJ
cord-263645-wupre5uj	151	39	yet	yet	CC
cord-263645-wupre5uj	151	40	reversible	reversible	JJ
cord-263645-wupre5uj	151	41	disulfide	disulfide	JJ
cord-263645-wupre5uj	151	42	linkages	linkage	NNS
cord-263645-wupre5uj	151	43	.	.	.
cord-263645-wupre5uj	152	1	The	the	DT
cord-263645-wupre5uj	152	2	binders	binder	NNS
cord-263645-wupre5uj	152	3	with	with	IN
cord-263645-wupre5uj	152	4	highest	high	JJS
cord-263645-wupre5uj	152	5	affinity	affinity	NN
cord-263645-wupre5uj	152	6	were	be	VBD
cord-263645-wupre5uj	152	7	thus	thus	RB
cord-263645-wupre5uj	152	8	enriched	enrich	VBN
cord-263645-wupre5uj	152	9	and	and	CC
cord-263645-wupre5uj	152	10	then	then	RB
cord-263645-wupre5uj	152	11	isolated	isolate	VBN
cord-263645-wupre5uj	152	12	,	,	,
cord-263645-wupre5uj	152	13	characterized	characterize	VBN
cord-263645-wupre5uj	152	14	,	,	,
cord-263645-wupre5uj	152	15	and	and	CC
cord-263645-wupre5uj	152	16	validated	validate	VBD
cord-263645-wupre5uj	152	17	for	for	IN
cord-263645-wupre5uj	152	18	RNAbinding	rnabinding	NN
cord-263645-wupre5uj	152	19	.	.	.
cord-263645-wupre5uj	153	1	After	after	IN
cord-263645-wupre5uj	153	2	replacing	replace	VBG
cord-263645-wupre5uj	153	3	the	the	DT
cord-263645-wupre5uj	153	4	disulfide	disulfide	JJ
cord-263645-wupre5uj	153	5	linkage	linkage	NN
cord-263645-wupre5uj	153	6	with	with	IN
cord-263645-wupre5uj	153	7	more	more	JJR
cord-263645-wupre5uj	153	8	sta	sta	JJ
cord-263645-wupre5uj	153	9	-	-	JJ
cord-263645-wupre5uj	153	10	ble	ble	JJ
cord-263645-wupre5uj	153	11	bioisosteres	bioisostere	NNS
cord-263645-wupre5uj	153	12	,	,	,
cord-263645-wupre5uj	153	13	the	the	DT
cord-263645-wupre5uj	153	14	method	method	NN
cord-263645-wupre5uj	153	15	yielded	yield	VBD
cord-263645-wupre5uj	153	16	bioactive	bioactive	JJ
cord-263645-wupre5uj	153	17	ligands	ligand	NNS
cord-263645-wupre5uj	153	18	for	for	IN
cord-263645-wupre5uj	153	19	two	two	CD
cord-263645-wupre5uj	153	20	RNAs	rna	NNS
cord-263645-wupre5uj	153	21	of	of	IN
cord-263645-wupre5uj	153	22	known	know	VBN
cord-263645-wupre5uj	153	23	structure	structure	NN
cord-263645-wupre5uj	153	24	:	:	:
cord-263645-wupre5uj	153	25	DM1	DM1	NNP
cord-263645-wupre5uj	153	26	r(CUG	r(cug	CD
cord-263645-wupre5uj	153	27	)	)	-RRB-
cord-263645-wupre5uj	153	28	exp	exp	XX
cord-263645-wupre5uj	153	29	,	,	,
cord-263645-wupre5uj	153	30	where	where	WRB
cord-263645-wupre5uj	153	31	statistically	statistically	RB
cord-263645-wupre5uj	153	32	significant	significant	JJ
cord-263645-wupre5uj	153	33	improvements	improvement	NNS
cord-263645-wupre5uj	153	34	in	in	IN
cord-263645-wupre5uj	153	35	splicing	splicing	NN
cord-263645-wupre5uj	153	36	were	be	VBD
cord-263645-wupre5uj	153	37	observed	observe	VBN
cord-263645-wupre5uj	153	38	in	in	IN
cord-263645-wupre5uj	153	39	mouse	mouse	NN
cord-263645-wupre5uj	153	40	models	model	NNS
cord-263645-wupre5uj	153	41	(	(	-LRB-
cord-263645-wupre5uj	153	42	70	70	CD
cord-263645-wupre5uj	153	43	)	)	-RRB-
cord-263645-wupre5uj	153	44	,	,	,
cord-263645-wupre5uj	153	45	and	and	CC
cord-263645-wupre5uj	153	46	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	153	47	frameshift	frameshift	NN
cord-263645-wupre5uj	153	48	-	-	HYPH
cord-263645-wupre5uj	153	49	stimulating	stimulate	VBG
cord-263645-wupre5uj	153	50	RNA	RNA	NNP
cord-263645-wupre5uj	153	51	,	,	,
cord-263645-wupre5uj	153	52	(	(	-LRB-
cord-263645-wupre5uj	153	53	71	71	CD
cord-263645-wupre5uj	153	54	,	,	,
cord-263645-wupre5uj	153	55	72	72	CD
cord-263645-wupre5uj	153	56	)	)	-RRB-
cord-263645-wupre5uj	153	57	where	where	WRB
cord-263645-wupre5uj	153	58	in	in	IN
cord-263645-wupre5uj	153	59	one	one	CD
cord-263645-wupre5uj	153	60	example	example	NN
cord-263645-wupre5uj	153	61	the	the	DT
cord-263645-wupre5uj	153	62	decrease	decrease	NN
cord-263645-wupre5uj	153	63	in	in	IN
cord-263645-wupre5uj	153	64	viral	viral	JJ
cord-263645-wupre5uj	153	65	infectivity	infectivity	NN
cord-263645-wupre5uj	153	66	(	(	-LRB-
cord-263645-wupre5uj	153	67	EC	EC	NNP
cord-263645-wupre5uj	153	68	50	50	CD
cord-263645-wupre5uj	153	69	values	value	NNS
cord-263645-wupre5uj	153	70	of	of	IN
cord-263645-wupre5uj	153	71	3.9	3.9	CD
cord-263645-wupre5uj	153	72	and	and	CC
cord-263645-wupre5uj	153	73	26	26	CD
cord-263645-wupre5uj	153	74	M	M	NNP
cord-263645-wupre5uj	153	75	)	)	-RRB-
cord-263645-wupre5uj	153	76	correlated	correlate	VBD
cord-263645-wupre5uj	153	77	to	to	IN
cord-263645-wupre5uj	153	78	frame	frame	NN
cord-263645-wupre5uj	153	79	-	-	HYPH
cord-263645-wupre5uj	153	80	shifting	shift	VBG
cord-263645-wupre5uj	153	81	activity	activity	NN
cord-263645-wupre5uj	153	82	(	(	-LRB-
cord-263645-wupre5uj	153	83	>	>	NFP
cord-263645-wupre5uj	153	84	50	50	CD
cord-263645-wupre5uj	153	85	%	%	NN
cord-263645-wupre5uj	153	86	at	at	IN
cord-263645-wupre5uj	153	87	50	50	CD
cord-263645-wupre5uj	153	88	M	M	NNP
cord-263645-wupre5uj	153	89	)	)	-RRB-
cord-263645-wupre5uj	153	90	in	in	IN
cord-263645-wupre5uj	153	91	cell	cell	NN
cord-263645-wupre5uj	153	92	culture	culture	NN
cord-263645-wupre5uj	153	93	(	(	-LRB-
cord-263645-wupre5uj	153	94	73	73	CD
cord-263645-wupre5uj	153	95	)	)	-RRB-
cord-263645-wupre5uj	153	96	.	.	.
cord-263645-wupre5uj	154	1	A	a	DT
cord-263645-wupre5uj	154	2	powerful	powerful	JJ
cord-263645-wupre5uj	154	3	advantage	advantage	NN
cord-263645-wupre5uj	154	4	of	of	IN
cord-263645-wupre5uj	154	5	DCC	DCC	NNP
cord-263645-wupre5uj	154	6	is	be	VBZ
cord-263645-wupre5uj	154	7	that	that	IN
cord-263645-wupre5uj	154	8	multivalent	multivalent	JJ
cord-263645-wupre5uj	154	9	ligands	ligand	NNS
cord-263645-wupre5uj	154	10	can	can	MD
cord-263645-wupre5uj	154	11	be	be	VB
cord-263645-wupre5uj	154	12	constructed	construct	VBN
cord-263645-wupre5uj	154	13	without	without	IN
cord-263645-wupre5uj	154	14	knowledge	knowledge	NN
cord-263645-wupre5uj	154	15	of	of	IN
cord-263645-wupre5uj	154	16	the	the	DT
cord-263645-wupre5uj	154	17	RNA	RNA	NNP
cord-263645-wupre5uj	154	18	structure	structure	NN
cord-263645-wupre5uj	154	19	,	,	,
cord-263645-wupre5uj	154	20	including	include	VBG
cord-263645-wupre5uj	154	21	larger	large	JJR
cord-263645-wupre5uj	154	22	and	and	CC
cord-263645-wupre5uj	154	23	complex	complex	JJ
cord-263645-wupre5uj	154	24	tertiary	tertiary	JJ
cord-263645-wupre5uj	154	25	folds	fold	NNS
cord-263645-wupre5uj	154	26	.	.	.
cord-263645-wupre5uj	155	1	In	in	IN
cord-263645-wupre5uj	155	2	general	general	JJ
cord-263645-wupre5uj	155	3	,	,	,
cord-263645-wupre5uj	155	4	both	both	DT
cord-263645-wupre5uj	155	5	rational	rational	JJ
cord-263645-wupre5uj	155	6	design	design	NN
cord-263645-wupre5uj	155	7	and	and	CC
cord-263645-wupre5uj	155	8	DCC	DCC	NNP
cord-263645-wupre5uj	155	9	yield	yield	VB
cord-263645-wupre5uj	155	10	multivalent	multivalent	JJ
cord-263645-wupre5uj	155	11	probes	probe	NNS
cord-263645-wupre5uj	155	12	with	with	IN
cord-263645-wupre5uj	155	13	significantly	significantly	RB
cord-263645-wupre5uj	155	14	increased	increase	VBN
cord-263645-wupre5uj	155	15	affinity	affinity	NN
cord-263645-wupre5uj	155	16	and	and	CC
cord-263645-wupre5uj	155	17	specificity	specificity	NN
cord-263645-wupre5uj	155	18	for	for	IN
cord-263645-wupre5uj	155	19	RNA	RNA	NNP
cord-263645-wupre5uj	155	20	targets	target	NNS
cord-263645-wupre5uj	155	21	relative	relative	JJ
cord-263645-wupre5uj	155	22	to	to	IN
cord-263645-wupre5uj	155	23	small	small	JJ
cord-263645-wupre5uj	155	24	molecules	molecule	NNS
cord-263645-wupre5uj	155	25	.	.	.
cord-263645-wupre5uj	156	1	While	while	IN
cord-263645-wupre5uj	156	2	achieving	achieve	VBG
cord-263645-wupre5uj	156	3	high	high	JJ
cord-263645-wupre5uj	156	4	potency	potency	NN
cord-263645-wupre5uj	156	5	in	in	IN
cord-263645-wupre5uj	156	6	biological	biological	JJ
cord-263645-wupre5uj	156	7	systems	system	NNS
cord-263645-wupre5uj	156	8	with	with	IN
cord-263645-wupre5uj	156	9	larger	large	JJR
cord-263645-wupre5uj	156	10	molecules	molecule	NNS
cord-263645-wupre5uj	156	11	may	may	MD
cord-263645-wupre5uj	156	12	require	require	VB
cord-263645-wupre5uj	156	13	more	more	JJR
cord-263645-wupre5uj	156	14	development	development	NN
cord-263645-wupre5uj	156	15	than	than	IN
cord-263645-wupre5uj	156	16	with	with	IN
cord-263645-wupre5uj	156	17	traditional	traditional	JJ
cord-263645-wupre5uj	156	18	small	small	JJ
cord-263645-wupre5uj	156	19	molecules	molecule	NNS
cord-263645-wupre5uj	156	20	,	,	,
cord-263645-wupre5uj	156	21	the	the	DT
cord-263645-wupre5uj	156	22	examples	example	NNS
cord-263645-wupre5uj	156	23	identified	identify	VBD
cord-263645-wupre5uj	156	24	support	support	VBP
cord-263645-wupre5uj	156	25	the	the	DT
cord-263645-wupre5uj	156	26	possibility	possibility	NN
cord-263645-wupre5uj	156	27	of	of	IN
cord-263645-wupre5uj	156	28	success	success	NN
cord-263645-wupre5uj	156	29	.	.	.
cord-263645-wupre5uj	157	1	Evaluating	evaluate	VBG
cord-263645-wupre5uj	157	2	target	target	NN
cord-263645-wupre5uj	157	3	engagement	engagement	NN
cord-263645-wupre5uj	157	4	,	,	,
cord-263645-wupre5uj	157	5	off	off	IN
cord-263645-wupre5uj	157	6	-	-	HYPH
cord-263645-wupre5uj	157	7	target	target	NN
cord-263645-wupre5uj	157	8	effects	effect	NNS
cord-263645-wupre5uj	157	9	,	,	,
cord-263645-wupre5uj	157	10	potency	potency	NN
cord-263645-wupre5uj	157	11	/	/	SYM
cord-263645-wupre5uj	157	12	appropriate	appropriate	JJ
cord-263645-wupre5uj	157	13	concentration	concentration	NN
cord-263645-wupre5uj	157	14	,	,	,
cord-263645-wupre5uj	157	15	and	and	CC
cord-263645-wupre5uj	157	16	other	other	JJ
cord-263645-wupre5uj	157	17	criteria	criterion	NNS
cord-263645-wupre5uj	157	18	is	be	VBZ
cord-263645-wupre5uj	157	19	critical	critical	JJ
cord-263645-wupre5uj	157	20	to	to	IN
cord-263645-wupre5uj	157	21	understanding	understand	VBG
cord-263645-wupre5uj	157	22	the	the	DT
cord-263645-wupre5uj	157	23	quality	quality	NN
cord-263645-wupre5uj	157	24	of	of	IN
cord-263645-wupre5uj	157	25	a	a	DT
cord-263645-wupre5uj	157	26	chemical	chemical	NN
cord-263645-wupre5uj	157	27	probe	probe	NN
cord-263645-wupre5uj	157	28	and	and	CC
cord-263645-wupre5uj	157	29	thus	thus	RB
cord-263645-wupre5uj	157	30	any	any	DT
cord-263645-wupre5uj	157	31	experimental	experimental	JJ
cord-263645-wupre5uj	157	32	conclusions	conclusion	NNS
cord-263645-wupre5uj	157	33	(	(	-LRB-
cord-263645-wupre5uj	157	34	11	11	CD
cord-263645-wupre5uj	157	35	,	,	,
cord-263645-wupre5uj	157	36	12	12	CD
cord-263645-wupre5uj	157	37	,	,	,
cord-263645-wupre5uj	157	38	74	74	CD
cord-263645-wupre5uj	157	39	,	,	,
cord-263645-wupre5uj	157	40	75	75	CD
cord-263645-wupre5uj	157	41	)	)	-RRB-
cord-263645-wupre5uj	157	42	.	.	.
cord-263645-wupre5uj	158	1	When	when	WRB
cord-263645-wupre5uj	158	2	curating	curate	VBG
cord-263645-wupre5uj	158	3	the	the	DT
cord-263645-wupre5uj	158	4	collection	collection	NN
cord-263645-wupre5uj	158	5	of	of	IN
cord-263645-wupre5uj	158	6	chemical	chemical	JJ
cord-263645-wupre5uj	158	7	probes	probe	NNS
cord-263645-wupre5uj	158	8	,	,	,
cord-263645-wupre5uj	158	9	strict	strict	JJ
cord-263645-wupre5uj	158	10	benchmarks	benchmark	NNS
cord-263645-wupre5uj	158	11	related	relate	VBN
cord-263645-wupre5uj	158	12	to	to	IN
cord-263645-wupre5uj	158	13	these	these	DT
cord-263645-wupre5uj	158	14	criteria	criterion	NNS
cord-263645-wupre5uj	158	15	could	could	MD
cord-263645-wupre5uj	158	16	not	not	RB
cord-263645-wupre5uj	158	17	be	be	VB
cord-263645-wupre5uj	158	18	included	include	VBN
cord-263645-wupre5uj	158	19	due	due	IN
cord-263645-wupre5uj	158	20	to	to	IN
cord-263645-wupre5uj	158	21	the	the	DT
cord-263645-wupre5uj	158	22	lack	lack	NN
cord-263645-wupre5uj	158	23	of	of	IN
cord-263645-wupre5uj	158	24	consistency	consistency	NN
cord-263645-wupre5uj	158	25	within	within	IN
cord-263645-wupre5uj	158	26	the	the	DT
cord-263645-wupre5uj	158	27	field	field	NN
cord-263645-wupre5uj	158	28	.	.	.
cord-263645-wupre5uj	159	1	In	in	IN
cord-263645-wupre5uj	159	2	the	the	DT
cord-263645-wupre5uj	159	3	next	next	JJ
cord-263645-wupre5uj	159	4	paragraphs	paragraph	NNS
cord-263645-wupre5uj	159	5	,	,	,
cord-263645-wupre5uj	159	6	the	the	DT
cord-263645-wupre5uj	159	7	characterization	characterization	NN
cord-263645-wupre5uj	159	8	techniques	technique	NNS
cord-263645-wupre5uj	159	9	utilized	utilize	VBN
cord-263645-wupre5uj	159	10	for	for	IN
cord-263645-wupre5uj	159	11	RNA	rna	NN
cord-263645-wupre5uj	159	12	-	-	HYPH
cord-263645-wupre5uj	159	13	targeted	target	VBN
cord-263645-wupre5uj	159	14	chemical	chemical	NN
cord-263645-wupre5uj	159	15	probes	probe	NNS
cord-263645-wupre5uj	159	16	will	will	MD
cord-263645-wupre5uj	159	17	be	be	VB
cord-263645-wupre5uj	159	18	described	describe	VBN
cord-263645-wupre5uj	159	19	for	for	IN
cord-263645-wupre5uj	159	20	each	each	DT
cord-263645-wupre5uj	159	21	biological	biological	JJ
cord-263645-wupre5uj	159	22	system	system	NN
cord-263645-wupre5uj	159	23	and	and	CC
cord-263645-wupre5uj	159	24	notable	notable	JJ
cord-263645-wupre5uj	159	25	examples	example	NNS
cord-263645-wupre5uj	159	26	highlighted	highlight	VBN
cord-263645-wupre5uj	159	27	.	.	.
cord-263645-wupre5uj	160	1	One	one	CD
cord-263645-wupre5uj	160	2	of	of	IN
cord-263645-wupre5uj	160	3	the	the	DT
cord-263645-wupre5uj	160	4	most	most	RBS
cord-263645-wupre5uj	160	5	common	common	JJ
cord-263645-wupre5uj	160	6	validation	validation	NN
cord-263645-wupre5uj	160	7	experiments	experiment	NNS
cord-263645-wupre5uj	160	8	in	in	IN
cord-263645-wupre5uj	160	9	bacterial	bacterial	JJ
cord-263645-wupre5uj	160	10	and	and	CC
cord-263645-wupre5uj	160	11	fungal	fungal	JJ
cord-263645-wupre5uj	160	12	systems	system	NNS
cord-263645-wupre5uj	160	13	was	be	VBD
cord-263645-wupre5uj	160	14	serial	serial	JJ
cord-263645-wupre5uj	160	15	passage	passage	NN
cord-263645-wupre5uj	160	16	(	(	-LRB-
cord-263645-wupre5uj	160	17	15	15	CD
cord-263645-wupre5uj	160	18	,	,	,
cord-263645-wupre5uj	160	19	31	31	CD
cord-263645-wupre5uj	160	20	,	,	,
cord-263645-wupre5uj	160	21	46	46	CD
cord-263645-wupre5uj	160	22	,	,	,
cord-263645-wupre5uj	160	23	62	62	CD
cord-263645-wupre5uj	160	24	,	,	,
cord-263645-wupre5uj	160	25	65	65	CD
cord-263645-wupre5uj	160	26	,	,	,
cord-263645-wupre5uj	160	27	76	76	CD
cord-263645-wupre5uj	160	28	,	,	,
cord-263645-wupre5uj	160	29	77	77	CD
cord-263645-wupre5uj	160	30	)	)	-RRB-
cord-263645-wupre5uj	160	31	.	.	.
cord-263645-wupre5uj	161	1	In	in	IN
cord-263645-wupre5uj	161	2	this	this	DT
cord-263645-wupre5uj	161	3	technique	technique	NN
cord-263645-wupre5uj	161	4	,	,	,
cord-263645-wupre5uj	161	5	ligand	ligand	NN
cord-263645-wupre5uj	161	6	resistant	resistant	JJ
cord-263645-wupre5uj	161	7	mutants	mutant	NNS
cord-263645-wupre5uj	161	8	were	be	VBD
cord-263645-wupre5uj	161	9	grown	grow	VBN
cord-263645-wupre5uj	161	10	in	in	IN
cord-263645-wupre5uj	161	11	the	the	DT
cord-263645-wupre5uj	161	12	presence	presence	NN
cord-263645-wupre5uj	161	13	of	of	IN
cord-263645-wupre5uj	161	14	compound	compound	NN
cord-263645-wupre5uj	161	15	and	and	CC
cord-263645-wupre5uj	161	16	mutations	mutation	NNS
cord-263645-wupre5uj	161	17	were	be	VBD
cord-263645-wupre5uj	161	18	mapped	map	VBN
cord-263645-wupre5uj	161	19	by	by	IN
cord-263645-wupre5uj	161	20	whole	whole	JJ
cord-263645-wupre5uj	161	21	-	-	HYPH
cord-263645-wupre5uj	161	22	genome	genome	NN
cord-263645-wupre5uj	161	23	sequencing	sequencing	NN
cord-263645-wupre5uj	161	24	.	.	.
cord-263645-wupre5uj	162	1	In	in	IN
cord-263645-wupre5uj	162	2	addition	addition	NN
cord-263645-wupre5uj	162	3	to	to	IN
cord-263645-wupre5uj	162	4	confirming	confirm	VBG
cord-263645-wupre5uj	162	5	target	target	NN
cord-263645-wupre5uj	162	6	engagement	engagement	NN
cord-263645-wupre5uj	162	7	,	,	,
cord-263645-wupre5uj	162	8	the	the	DT
cord-263645-wupre5uj	162	9	results	result	NNS
cord-263645-wupre5uj	162	10	revealed	reveal	VBD
cord-263645-wupre5uj	162	11	off	off	IN
cord-263645-wupre5uj	162	12	-	-	HYPH
cord-263645-wupre5uj	162	13	target	target	NN
cord-263645-wupre5uj	162	14	effects	effect	NNS
cord-263645-wupre5uj	162	15	and	and	CC
cord-263645-wupre5uj	162	16	unexpected	unexpected	JJ
cord-263645-wupre5uj	162	17	modes	mode	NNS
cord-263645-wupre5uj	162	18	of	of	IN
cord-263645-wupre5uj	162	19	action	action	NN
cord-263645-wupre5uj	162	20	.	.	.
cord-263645-wupre5uj	163	1	Further	further	RB
cord-263645-wupre5uj	163	2	,	,	,
cord-263645-wupre5uj	163	3	select	select	JJ
cord-263645-wupre5uj	163	4	examples	example	NNS
cord-263645-wupre5uj	163	5	performed	perform	VBD
cord-263645-wupre5uj	163	6	the	the	DT
cord-263645-wupre5uj	163	7	serial	serial	JJ
cord-263645-wupre5uj	163	8	passage	passage	NN
cord-263645-wupre5uj	163	9	experiments	experiment	NNS
cord-263645-wupre5uj	163	10	in	in	IN
cord-263645-wupre5uj	163	11	multiple	multiple	JJ
cord-263645-wupre5uj	163	12	bacterial	bacterial	JJ
cord-263645-wupre5uj	163	13	strains	strain	NNS
cord-263645-wupre5uj	163	14	and	and	CC
cord-263645-wupre5uj	163	15	measured	measure	VBN
cord-263645-wupre5uj	163	16	binding	bind	VBG
cord-263645-wupre5uj	163	17	affinity	affinity	NN
cord-263645-wupre5uj	163	18	to	to	IN
cord-263645-wupre5uj	163	19	the	the	DT
cord-263645-wupre5uj	163	20	mutants	mutant	NNS
cord-263645-wupre5uj	163	21	in	in	IN
cord-263645-wupre5uj	163	22	vitro	vitro	FW
cord-263645-wupre5uj	163	23	,	,	,
cord-263645-wupre5uj	163	24	which	which	WDT
cord-263645-wupre5uj	163	25	provided	provide	VBD
cord-263645-wupre5uj	163	26	added	added	JJ
cord-263645-wupre5uj	163	27	confidence	confidence	NN
cord-263645-wupre5uj	163	28	in	in	IN
cord-263645-wupre5uj	163	29	target	target	NN
cord-263645-wupre5uj	163	30	engagement	engagement	NN
cord-263645-wupre5uj	163	31	(	(	-LRB-
cord-263645-wupre5uj	163	32	15	15	CD
cord-263645-wupre5uj	163	33	,	,	,
cord-263645-wupre5uj	163	34	31	31	CD
cord-263645-wupre5uj	163	35	,	,	,
cord-263645-wupre5uj	163	36	77	77	CD
cord-263645-wupre5uj	163	37	)	)	-RRB-
cord-263645-wupre5uj	163	38	.	.	.
cord-263645-wupre5uj	164	1	In	in	IN
cord-263645-wupre5uj	164	2	select	select	JJ
cord-263645-wupre5uj	164	3	cases	case	NNS
cord-263645-wupre5uj	164	4	where	where	WRB
cord-263645-wupre5uj	164	5	serial	serial	JJ
cord-263645-wupre5uj	164	6	passage	passage	NN
cord-263645-wupre5uj	164	7	experiments	experiment	NNS
cord-263645-wupre5uj	164	8	did	do	VBD
cord-263645-wupre5uj	164	9	not	not	RB
cord-263645-wupre5uj	164	10	yield	yield	VB
cord-263645-wupre5uj	164	11	mutated	mutate	VBN
cord-263645-wupre5uj	164	12	isolates	isolate	NNS
cord-263645-wupre5uj	164	13	,	,	,
cord-263645-wupre5uj	164	14	the	the	DT
cord-263645-wupre5uj	164	15	ligands	ligand	NNS
cord-263645-wupre5uj	164	16	were	be	VBD
cord-263645-wupre5uj	164	17	tested	test	VBN
cord-263645-wupre5uj	164	18	against	against	IN
cord-263645-wupre5uj	164	19	mutants	mutant	NNS
cord-263645-wupre5uj	164	20	with	with	IN
cord-263645-wupre5uj	164	21	established	establish	VBN
cord-263645-wupre5uj	164	22	variations	variation	NNS
cord-263645-wupre5uj	164	23	in	in	IN
cord-263645-wupre5uj	164	24	structure	structure	NN
cord-263645-wupre5uj	164	25	or	or	CC
cord-263645-wupre5uj	164	26	activity	activity	NN
cord-263645-wupre5uj	164	27	(	(	-LRB-
cord-263645-wupre5uj	164	28	76	76	CD
cord-263645-wupre5uj	164	29	,	,	,
cord-263645-wupre5uj	164	30	65	65	CD
cord-263645-wupre5uj	164	31	)	)	-RRB-
cord-263645-wupre5uj	164	32	.	.	.
cord-263645-wupre5uj	165	1	Another	another	DT
cord-263645-wupre5uj	165	2	powerful	powerful	JJ
cord-263645-wupre5uj	165	3	strategy	strategy	NN
cord-263645-wupre5uj	165	4	for	for	IN
cord-263645-wupre5uj	165	5	assessing	assess	VBG
cord-263645-wupre5uj	165	6	target	target	NN
cord-263645-wupre5uj	165	7	engagement	engagement	NN
cord-263645-wupre5uj	165	8	in	in	IN
cord-263645-wupre5uj	165	9	riboswitches	riboswitche	NNS
cord-263645-wupre5uj	165	10	was	be	VBD
cord-263645-wupre5uj	165	11	phenotype	phenotype	NN
cord-263645-wupre5uj	165	12	rescue	rescue	NN
cord-263645-wupre5uj	165	13	by	by	IN
cord-263645-wupre5uj	165	14	addition	addition	NN
cord-263645-wupre5uj	165	15	of	of	IN
cord-263645-wupre5uj	165	16	the	the	DT
cord-263645-wupre5uj	165	17	native	native	JJ
cord-263645-wupre5uj	165	18	ligand	ligand	NN
cord-263645-wupre5uj	165	19	(	(	-LRB-
cord-263645-wupre5uj	165	20	15	15	CD
cord-263645-wupre5uj	165	21	,	,	,
cord-263645-wupre5uj	165	22	46	46	CD
cord-263645-wupre5uj	165	23	)	)	-RRB-
cord-263645-wupre5uj	165	24	.	.	.
cord-263645-wupre5uj	166	1	Lastly	lastly	RB
cord-263645-wupre5uj	166	2	,	,	,
cord-263645-wupre5uj	166	3	several	several	JJ
cord-263645-wupre5uj	166	4	of	of	IN
cord-263645-wupre5uj	166	5	the	the	DT
cord-263645-wupre5uj	166	6	targeted	target	VBN
cord-263645-wupre5uj	166	7	RNA	RNA	NNP
cord-263645-wupre5uj	166	8	elements	element	NNS
cord-263645-wupre5uj	166	9	regulated	regulate	VBD
cord-263645-wupre5uj	166	10	the	the	DT
cord-263645-wupre5uj	166	11	expression	expression	NN
cord-263645-wupre5uj	166	12	or	or	CC
cord-263645-wupre5uj	166	13	translation	translation	NN
cord-263645-wupre5uj	166	14	of	of	IN
cord-263645-wupre5uj	166	15	specific	specific	JJ
cord-263645-wupre5uj	166	16	genes	gene	NNS
cord-263645-wupre5uj	166	17	,	,	,
cord-263645-wupre5uj	166	18	which	which	WDT
cord-263645-wupre5uj	166	19	was	be	VBD
cord-263645-wupre5uj	166	20	assessed	assess	VBN
cord-263645-wupre5uj	166	21	by	by	IN
cord-263645-wupre5uj	166	22	measuring	measure	VBG
cord-263645-wupre5uj	166	23	the	the	DT
cord-263645-wupre5uj	166	24	quantity	quantity	NN
cord-263645-wupre5uj	166	25	of	of	IN
cord-263645-wupre5uj	166	26	the	the	DT
cord-263645-wupre5uj	166	27	RNA	RNA	NNP
cord-263645-wupre5uj	166	28	or	or	CC
cord-263645-wupre5uj	166	29	protein	protein	NN
cord-263645-wupre5uj	166	30	,	,	,
cord-263645-wupre5uj	166	31	respectively	respectively	RB
cord-263645-wupre5uj	166	32	.	.	.
cord-263645-wupre5uj	167	1	One	one	CD
cord-263645-wupre5uj	167	2	study	study	NN
cord-263645-wupre5uj	167	3	went	go	VBD
cord-263645-wupre5uj	167	4	beyond	beyond	IN
cord-263645-wupre5uj	167	5	measuring	measure	VBG
cord-263645-wupre5uj	167	6	the	the	DT
cord-263645-wupre5uj	167	7	expected	expect	VBN
cord-263645-wupre5uj	167	8	transcripts	transcript	NNS
cord-263645-wupre5uj	167	9	and	and	CC
cord-263645-wupre5uj	167	10	performed	perform	VBD
cord-263645-wupre5uj	167	11	a	a	DT
cord-263645-wupre5uj	167	12	transcriptomic	transcriptomic	NNP
cord-263645-wupre5uj	167	13	microarray	microarray	NN
cord-263645-wupre5uj	167	14	analysis	analysis	NN
cord-263645-wupre5uj	167	15	of	of	IN
cord-263645-wupre5uj	167	16	genes	gene	NNS
cord-263645-wupre5uj	167	17	involved	involve	VBN
cord-263645-wupre5uj	167	18	in	in	IN
cord-263645-wupre5uj	167	19	many	many	JJ
cord-263645-wupre5uj	167	20	different	different	JJ
cord-263645-wupre5uj	167	21	cellular	cellular	JJ
cord-263645-wupre5uj	167	22	processes	process	NNS
cord-263645-wupre5uj	167	23	(	(	-LRB-
cord-263645-wupre5uj	167	24	46	46	CD
cord-263645-wupre5uj	167	25	)	)	-RRB-
cord-263645-wupre5uj	167	26	.	.	.
cord-263645-wupre5uj	168	1	The	the	DT
cord-263645-wupre5uj	168	2	observed	observed	JJ
cord-263645-wupre5uj	168	3	repression	repression	NN
cord-263645-wupre5uj	168	4	was	be	VBD
cord-263645-wupre5uj	168	5	consistent	consistent	JJ
cord-263645-wupre5uj	168	6	with	with	IN
cord-263645-wupre5uj	168	7	riboswitch	riboswitch	NN
cord-263645-wupre5uj	168	8	inhibition	inhibition	NN
cord-263645-wupre5uj	168	9	,	,	,
cord-263645-wupre5uj	168	10	although	although	IN
cord-263645-wupre5uj	168	11	addition	addition	NN
cord-263645-wupre5uj	168	12	of	of	IN
cord-263645-wupre5uj	168	13	the	the	DT
cord-263645-wupre5uj	168	14	native	native	JJ
cord-263645-wupre5uj	168	15	ligand	ligand	NN
cord-263645-wupre5uj	168	16	failed	fail	VBD
cord-263645-wupre5uj	168	17	to	to	TO
cord-263645-wupre5uj	168	18	rescue	rescue	VB
cord-263645-wupre5uj	168	19	the	the	DT
cord-263645-wupre5uj	168	20	expression	expression	NN
cord-263645-wupre5uj	168	21	of	of	IN
cord-263645-wupre5uj	168	22	several	several	JJ
cord-263645-wupre5uj	168	23	genes	gene	NNS
cord-263645-wupre5uj	168	24	,	,	,
cord-263645-wupre5uj	168	25	indicating	indicate	VBG
cord-263645-wupre5uj	168	26	a	a	DT
cord-263645-wupre5uj	168	27	potential	potential	JJ
cord-263645-wupre5uj	168	28	cellular	cellular	JJ
cord-263645-wupre5uj	168	29	stress	stress	NN
cord-263645-wupre5uj	168	30	response	response	NN
cord-263645-wupre5uj	168	31	.	.	.
cord-263645-wupre5uj	169	1	This	this	DT
cord-263645-wupre5uj	169	2	strategy	strategy	NN
cord-263645-wupre5uj	169	3	and	and	CC
cord-263645-wupre5uj	169	4	other	other	JJ
cord-263645-wupre5uj	169	5	genome	genome	NN
cord-263645-wupre5uj	169	6	-	-	HYPH
cord-263645-wupre5uj	169	7	wide	wide	JJ
cord-263645-wupre5uj	169	8	analyses	analysis	NNS
cord-263645-wupre5uj	169	9	can	can	MD
cord-263645-wupre5uj	169	10	provide	provide	VB
cord-263645-wupre5uj	169	11	compelling	compelling	JJ
cord-263645-wupre5uj	169	12	evidence	evidence	NN
cord-263645-wupre5uj	169	13	of	of	IN
cord-263645-wupre5uj	169	14	target	target	NN
cord-263645-wupre5uj	169	15	engagement	engagement	NN
cord-263645-wupre5uj	169	16	,	,	,
cord-263645-wupre5uj	169	17	though	though	IN
cord-263645-wupre5uj	169	18	it	-PRON-	PRP
cord-263645-wupre5uj	169	19	must	must	MD
cord-263645-wupre5uj	169	20	be	be	VB
cord-263645-wupre5uj	169	21	noted	note	VBN
cord-263645-wupre5uj	169	22	that	that	DT
cord-263645-wupre5uj	169	23	target	target	NN
cord-263645-wupre5uj	169	24	specificity	specificity	NN
cord-263645-wupre5uj	169	25	does	do	VBZ
cord-263645-wupre5uj	169	26	not	not	RB
cord-263645-wupre5uj	169	27	always	always	RB
cord-263645-wupre5uj	169	28	lead	lead	VB
cord-263645-wupre5uj	169	29	to	to	IN
cord-263645-wupre5uj	169	30	biological	biological	JJ
cord-263645-wupre5uj	169	31	specificity	specificity	NN
cord-263645-wupre5uj	169	32	(	(	-LRB-
cord-263645-wupre5uj	169	33	12	12	CD
cord-263645-wupre5uj	169	34	)	)	-RRB-
cord-263645-wupre5uj	169	35	.	.	.
cord-263645-wupre5uj	170	1	Compared	compare	VBN
cord-263645-wupre5uj	170	2	to	to	IN
cord-263645-wupre5uj	170	3	the	the	DT
cord-263645-wupre5uj	170	4	other	other	JJ
cord-263645-wupre5uj	170	5	systems	system	NNS
cord-263645-wupre5uj	170	6	,	,	,
cord-263645-wupre5uj	170	7	chemical	chemical	NN
cord-263645-wupre5uj	170	8	probes	probe	NNS
cord-263645-wupre5uj	170	9	targeting	target	VBG
cord-263645-wupre5uj	170	10	viral	viral	JJ
cord-263645-wupre5uj	170	11	RNAs	rna	NNS
cord-263645-wupre5uj	170	12	were	be	VBD
cord-263645-wupre5uj	170	13	less	less	RBR
cord-263645-wupre5uj	170	14	characterized	characterize	VBN
cord-263645-wupre5uj	170	15	in	in	IN
cord-263645-wupre5uj	170	16	terms	term	NNS
cord-263645-wupre5uj	170	17	of	of	IN
cord-263645-wupre5uj	170	18	target	target	NN
cord-263645-wupre5uj	170	19	engagement	engagement	NN
cord-263645-wupre5uj	170	20	and	and	CC
cord-263645-wupre5uj	170	21	specific	specific	JJ
cord-263645-wupre5uj	170	22	activity	activity	NN
cord-263645-wupre5uj	170	23	.	.	.
cord-263645-wupre5uj	171	1	A	a	DT
cord-263645-wupre5uj	171	2	select	select	JJ
cord-263645-wupre5uj	171	3	few	few	JJ
cord-263645-wupre5uj	171	4	studies	study	NNS
cord-263645-wupre5uj	171	5	validated	validate	VBD
cord-263645-wupre5uj	171	6	probe	probe	NN
cord-263645-wupre5uj	171	7	activity	activity	NN
cord-263645-wupre5uj	171	8	by	by	IN
cord-263645-wupre5uj	171	9	testing	test	VBG
cord-263645-wupre5uj	171	10	mutant	mutant	JJ
cord-263645-wupre5uj	171	11	versions	version	NNS
cord-263645-wupre5uj	171	12	of	of	IN
cord-263645-wupre5uj	171	13	the	the	DT
cord-263645-wupre5uj	171	14	virus	virus	NN
cord-263645-wupre5uj	171	15	(	(	-LRB-
cord-263645-wupre5uj	171	16	49	49	CD
cord-263645-wupre5uj	171	17	,	,	,
cord-263645-wupre5uj	171	18	78	78	CD
cord-263645-wupre5uj	171	19	)	)	-RRB-
cord-263645-wupre5uj	171	20	or	or	CC
cord-263645-wupre5uj	171	21	closely	closely	RB
cord-263645-wupre5uj	171	22	related	related	JJ
cord-263645-wupre5uj	171	23	native	native	JJ
cord-263645-wupre5uj	171	24	viruses	virus	NNS
cord-263645-wupre5uj	171	25	(	(	-LRB-
cord-263645-wupre5uj	171	26	30	30	CD
cord-263645-wupre5uj	171	27	,	,	,
cord-263645-wupre5uj	171	28	73	73	CD
cord-263645-wupre5uj	171	29	)	)	-RRB-
cord-263645-wupre5uj	171	30	.	.	.
cord-263645-wupre5uj	172	1	Notably	notably	RB
cord-263645-wupre5uj	172	2	,	,	,
cord-263645-wupre5uj	172	3	one	one	CD
cord-263645-wupre5uj	172	4	report	report	NN
cord-263645-wupre5uj	172	5	validated	validate	VBD
cord-263645-wupre5uj	172	6	probe	probe	NN
cord-263645-wupre5uj	172	7	activity	activity	NN
cord-263645-wupre5uj	172	8	with	with	IN
cord-263645-wupre5uj	172	9	a	a	DT
cord-263645-wupre5uj	172	10	second	second	JJ
cord-263645-wupre5uj	172	11	research	research	NN
cord-263645-wupre5uj	172	12	group	group	NN
cord-263645-wupre5uj	172	13	to	to	TO
cord-263645-wupre5uj	172	14	ensure	ensure	VB
cord-263645-wupre5uj	172	15	reproducibility	reproducibility	NN
cord-263645-wupre5uj	172	16	of	of	IN
cord-263645-wupre5uj	172	17	the	the	DT
cord-263645-wupre5uj	172	18	biological	biological	JJ
cord-263645-wupre5uj	172	19	effect	effect	NN
cord-263645-wupre5uj	172	20	(	(	-LRB-
cord-263645-wupre5uj	172	21	71	71	CD
cord-263645-wupre5uj	172	22	)	)	-RRB-
cord-263645-wupre5uj	172	23	.	.	.
cord-263645-wupre5uj	173	1	RNAspecific	RNAspecific	NNP
cord-263645-wupre5uj	173	2	reporter	reporter	NN
cord-263645-wupre5uj	173	3	systems	system	NNS
cord-263645-wupre5uj	173	4	were	be	VBD
cord-263645-wupre5uj	173	5	occasionally	occasionally	RB
cord-263645-wupre5uj	173	6	used	use	VBN
cord-263645-wupre5uj	173	7	to	to	TO
cord-263645-wupre5uj	173	8	confirm	confirm	VB
cord-263645-wupre5uj	173	9	on	on	IN
cord-263645-wupre5uj	173	10	-	-	HYPH
cord-263645-wupre5uj	173	11	target	target	NN
cord-263645-wupre5uj	173	12	effects	effect	NNS
cord-263645-wupre5uj	173	13	,	,	,
cord-263645-wupre5uj	173	14	including	include	VBG
cord-263645-wupre5uj	173	15	fusion	fusion	NN
cord-263645-wupre5uj	173	16	-	-	HYPH
cord-263645-wupre5uj	173	17	induced	induce	VBN
cord-263645-wupre5uj	173	18	gene	gene	NN
cord-263645-wupre5uj	173	19	stimulation	stimulation	NN
cord-263645-wupre5uj	173	20	(	(	-LRB-
cord-263645-wupre5uj	173	21	79	79	CD
cord-263645-wupre5uj	173	22	)	)	-RRB-
cord-263645-wupre5uj	173	23	,	,	,
cord-263645-wupre5uj	173	24	heterologous	heterologous	NNP
cord-263645-wupre5uj	173	25	tethering	tethering	NN
cord-263645-wupre5uj	173	26	(	(	-LRB-
cord-263645-wupre5uj	173	27	54	54	CD
cord-263645-wupre5uj	173	28	)	)	-RRB-
cord-263645-wupre5uj	173	29	,	,	,
cord-263645-wupre5uj	173	30	and	and	CC
cord-263645-wupre5uj	173	31	a	a	DT
cord-263645-wupre5uj	173	32	viral	viral	JJ
cord-263645-wupre5uj	173	33	protein	protein	NN
cord-263645-wupre5uj	173	34	reporter	reporter	NN
cord-263645-wupre5uj	173	35	(	(	-LRB-
cord-263645-wupre5uj	173	36	48	48	CD
cord-263645-wupre5uj	173	37	)	)	-RRB-
cord-263645-wupre5uj	173	38	.	.	.
cord-263645-wupre5uj	174	1	A	a	DT
cord-263645-wupre5uj	174	2	noteworthy	noteworthy	JJ
cord-263645-wupre5uj	174	3	example	example	NN
cord-263645-wupre5uj	174	4	of	of	IN
cord-263645-wupre5uj	174	5	assessing	assess	VBG
cord-263645-wupre5uj	174	6	off	off	IN
cord-263645-wupre5uj	174	7	-	-	HYPH
cord-263645-wupre5uj	174	8	target	target	NN
cord-263645-wupre5uj	174	9	effects	effect	NNS
cord-263645-wupre5uj	174	10	was	be	VBD
cord-263645-wupre5uj	174	11	the	the	DT
cord-263645-wupre5uj	174	12	use	use	NN
cord-263645-wupre5uj	174	13	of	of	IN
cord-263645-wupre5uj	174	14	RNA	RNA	NNP
cord-263645-wupre5uj	174	15	-	-	HYPH
cord-263645-wupre5uj	174	16	Seq	Seq	NNP
cord-263645-wupre5uj	174	17	at	at	IN
cord-263645-wupre5uj	174	18	increasing	increase	VBG
cord-263645-wupre5uj	174	19	ligand	ligand	NN
cord-263645-wupre5uj	174	20	concentrations	concentration	NNS
cord-263645-wupre5uj	174	21	in	in	IN
cord-263645-wupre5uj	174	22	the	the	DT
cord-263645-wupre5uj	174	23	absence	absence	NN
cord-263645-wupre5uj	174	24	of	of	IN
cord-263645-wupre5uj	174	25	the	the	DT
cord-263645-wupre5uj	174	26	target	target	NN
cord-263645-wupre5uj	174	27	RNA	RNA	NNP
cord-263645-wupre5uj	174	28	(	(	-LRB-
cord-263645-wupre5uj	174	29	72	72	CD
cord-263645-wupre5uj	174	30	)	)	-RRB-
cord-263645-wupre5uj	174	31	.	.	.
cord-263645-wupre5uj	175	1	The	the	DT
cord-263645-wupre5uj	175	2	experiment	experiment	NN
cord-263645-wupre5uj	175	3	in	in	IN
cord-263645-wupre5uj	175	4	HEK293	HEK293	NNP
cord-263645-wupre5uj	175	5	T	T	NNP
cord-263645-wupre5uj	175	6	cells	cell	NNS
cord-263645-wupre5uj	175	7	revealed	reveal	VBD
cord-263645-wupre5uj	175	8	that	that	IN
cord-263645-wupre5uj	175	9	53	53	CD
cord-263645-wupre5uj	175	10	of	of	IN
cord-263645-wupre5uj	175	11	the	the	DT
cord-263645-wupre5uj	175	12	17	17	CD
cord-263645-wupre5uj	175	13	822	822	CD
cord-263645-wupre5uj	175	14	transcripts	transcript	NNS
cord-263645-wupre5uj	175	15	assayed	assay	VBN
cord-263645-wupre5uj	175	16	had	have	VBD
cord-263645-wupre5uj	175	17	statistically	statistically	RB
cord-263645-wupre5uj	175	18	significant	significant	JJ
cord-263645-wupre5uj	175	19	alterations	alteration	NNS
cord-263645-wupre5uj	175	20	at	at	IN
cord-263645-wupre5uj	175	21	two	two	CD
cord-263645-wupre5uj	175	22	concentrations	concentration	NNS
cord-263645-wupre5uj	175	23	,	,	,
cord-263645-wupre5uj	175	24	potentially	potentially	RB
cord-263645-wupre5uj	175	25	reflecting	reflect	VBG
cord-263645-wupre5uj	175	26	a	a	DT
cord-263645-wupre5uj	175	27	cellular	cellular	JJ
cord-263645-wupre5uj	175	28	stress	stress	NN
cord-263645-wupre5uj	175	29	response	response	NN
cord-263645-wupre5uj	175	30	.	.	.
cord-263645-wupre5uj	176	1	It	-PRON-	PRP
cord-263645-wupre5uj	176	2	is	be	VBZ
cord-263645-wupre5uj	176	3	also	also	RB
cord-263645-wupre5uj	176	4	intriguing	intriguing	JJ
cord-263645-wupre5uj	176	5	that	that	IN
cord-263645-wupre5uj	176	6	the	the	DT
cord-263645-wupre5uj	176	7	most	most	RBS
cord-263645-wupre5uj	176	8	biologically	biologically	RB
cord-263645-wupre5uj	176	9	potent	potent	JJ
cord-263645-wupre5uj	176	10	ligand	ligand	NN
cord-263645-wupre5uj	176	11	in	in	IN
cord-263645-wupre5uj	176	12	this	this	DT
cord-263645-wupre5uj	176	13	study	study	NN
cord-263645-wupre5uj	176	14	was	be	VBD
cord-263645-wupre5uj	176	15	the	the	DT
cord-263645-wupre5uj	176	16	least	least	RBS
cord-263645-wupre5uj	176	17	selective	selective	JJ
cord-263645-wupre5uj	176	18	analog	analog	NN
cord-263645-wupre5uj	176	19	in	in	IN
cord-263645-wupre5uj	176	20	an	an	DT
cord-263645-wupre5uj	176	21	in	in	FW
cord-263645-wupre5uj	176	22	vitro	vitro	FW
cord-263645-wupre5uj	176	23	tRNA	trna	NN
cord-263645-wupre5uj	176	24	competition	competition	NN
cord-263645-wupre5uj	176	25	assay	assay	NN
cord-263645-wupre5uj	176	26	.	.	.
cord-263645-wupre5uj	177	1	This	this	DT
cord-263645-wupre5uj	177	2	observation	observation	NN
cord-263645-wupre5uj	177	3	underlies	underlie	VBZ
cord-263645-wupre5uj	177	4	potential	potential	JJ
cord-263645-wupre5uj	177	5	differences	difference	NNS
cord-263645-wupre5uj	177	6	in	in	IN
cord-263645-wupre5uj	177	7	cellular	cellular	JJ
cord-263645-wupre5uj	177	8	activity	activity	NN
cord-263645-wupre5uj	177	9	versus	versus	FW
cord-263645-wupre5uj	177	10	in	in	IN
cord-263645-wupre5uj	177	11	vitro	vitro	FW
cord-263645-wupre5uj	177	12	binding	bind	VBG
cord-263645-wupre5uj	177	13	selectivity	selectivity	NN
cord-263645-wupre5uj	177	14	and	and	CC
cord-263645-wupre5uj	177	15	thus	thus	RB
cord-263645-wupre5uj	177	16	the	the	DT
cord-263645-wupre5uj	177	17	importance	importance	NN
cord-263645-wupre5uj	177	18	of	of	IN
cord-263645-wupre5uj	177	19	progressing	progress	VBG
cord-263645-wupre5uj	177	20	multiple	multiple	JJ
cord-263645-wupre5uj	177	21	ligands	ligand	NNS
cord-263645-wupre5uj	177	22	to	to	IN
cord-263645-wupre5uj	177	23	biological	biological	JJ
cord-263645-wupre5uj	177	24	assays	assay	NNS
cord-263645-wupre5uj	177	25	.	.	.
cord-263645-wupre5uj	178	1	There	there	EX
cord-263645-wupre5uj	178	2	are	be	VBP
cord-263645-wupre5uj	178	3	several	several	JJ
cord-263645-wupre5uj	178	4	noteworthy	noteworthy	JJ
cord-263645-wupre5uj	178	5	examples	example	NNS
cord-263645-wupre5uj	178	6	of	of	IN
cord-263645-wupre5uj	178	7	probing	probe	VBG
cord-263645-wupre5uj	178	8	ligand	ligand	NN
cord-263645-wupre5uj	178	9	promiscuity	promiscuity	NN
cord-263645-wupre5uj	178	10	and/or	and/or	CC
cord-263645-wupre5uj	178	11	selectivity	selectivity	NN
cord-263645-wupre5uj	178	12	in	in	IN
cord-263645-wupre5uj	178	13	human	human	JJ
cord-263645-wupre5uj	178	14	systems	system	NNS
cord-263645-wupre5uj	178	15	.	.	.
cord-263645-wupre5uj	179	1	Multiple	multiple	JJ
cord-263645-wupre5uj	179	2	studies	study	NNS
cord-263645-wupre5uj	179	3	utilized	utilize	VBN
cord-263645-wupre5uj	179	4	genome	genome	NN
cord-263645-wupre5uj	179	5	-	-	HYPH
cord-263645-wupre5uj	179	6	wide	wide	JJ
cord-263645-wupre5uj	179	7	analyses	analysis	NNS
cord-263645-wupre5uj	179	8	to	to	TO
cord-263645-wupre5uj	179	9	globally	globally	RB
cord-263645-wupre5uj	179	10	assess	assess	VB
cord-263645-wupre5uj	179	11	changes	change	NNS
cord-263645-wupre5uj	179	12	in	in	IN
cord-263645-wupre5uj	179	13	miRNA	miRNA	NNP
cord-263645-wupre5uj	179	14	,	,	,
cord-263645-wupre5uj	179	15	(	(	-LRB-
cord-263645-wupre5uj	179	16	16	16	CD
cord-263645-wupre5uj	179	17	,	,	,
cord-263645-wupre5uj	179	18	17	17	CD
cord-263645-wupre5uj	179	19	,	,	,
cord-263645-wupre5uj	179	20	59	59	CD
cord-263645-wupre5uj	179	21	,	,	,
cord-263645-wupre5uj	179	22	60	60	CD
cord-263645-wupre5uj	179	23	,	,	,
cord-263645-wupre5uj	179	24	80	80	CD
cord-263645-wupre5uj	179	25	)	)	-RRB-
cord-263645-wupre5uj	180	1	mRNA	mRNA	NNP
cord-263645-wupre5uj	180	2	,	,	,
cord-263645-wupre5uj	180	3	(	(	-LRB-
cord-263645-wupre5uj	180	4	18	18	CD
cord-263645-wupre5uj	180	5	,	,	,
cord-263645-wupre5uj	180	6	50	50	CD
cord-263645-wupre5uj	180	7	)	)	-RRB-
cord-263645-wupre5uj	180	8	or	or	CC
cord-263645-wupre5uj	180	9	splicing	splicing	NN
cord-263645-wupre5uj	180	10	(	(	-LRB-
cord-263645-wupre5uj	180	11	18	18	CD
cord-263645-wupre5uj	180	12	,	,	,
cord-263645-wupre5uj	180	13	21	21	CD
cord-263645-wupre5uj	180	14	,	,	,
cord-263645-wupre5uj	180	15	47	47	CD
cord-263645-wupre5uj	180	16	,	,	,
cord-263645-wupre5uj	180	17	(	(	-LRB-
cord-263645-wupre5uj	180	18	81	81	CD
cord-263645-wupre5uj	180	19	)	)	-RRB-
cord-263645-wupre5uj	180	20	(	(	-LRB-
cord-263645-wupre5uj	180	21	82	82	CD
cord-263645-wupre5uj	180	22	)	)	-RRB-
cord-263645-wupre5uj	181	1	(	(	-LRB-
cord-263645-wupre5uj	181	2	83	83	CD
cord-263645-wupre5uj	181	3	)	)	-RRB-
cord-263645-wupre5uj	182	1	(	(	-LRB-
cord-263645-wupre5uj	182	2	84	84	CD
cord-263645-wupre5uj	182	3	)	)	-RRB-
cord-263645-wupre5uj	182	4	(	(	-LRB-
cord-263645-wupre5uj	182	5	85	85	CD
cord-263645-wupre5uj	182	6	)	)	-RRB-
cord-263645-wupre5uj	182	7	)	)	-RRB-
cord-263645-wupre5uj	182	8	levels	level	NNS
cord-263645-wupre5uj	182	9	compared	compare	VBN
cord-263645-wupre5uj	182	10	to	to	IN
cord-263645-wupre5uj	182	11	the	the	DT
cord-263645-wupre5uj	182	12	target	target	NN
cord-263645-wupre5uj	182	13	RNA	RNA	NNP
cord-263645-wupre5uj	182	14	or	or	CC
cord-263645-wupre5uj	182	15	process	process	NN
cord-263645-wupre5uj	182	16	.	.	.
cord-263645-wupre5uj	183	1	Toward	toward	IN
cord-263645-wupre5uj	183	2	a	a	DT
cord-263645-wupre5uj	183	3	more	more	RBR
cord-263645-wupre5uj	183	4	direct	direct	JJ
cord-263645-wupre5uj	183	5	assessment	assessment	NN
cord-263645-wupre5uj	183	6	,	,	,
cord-263645-wupre5uj	183	7	chemical	chemical	NN
cord-263645-wupre5uj	183	8	cross	cross	NN
cord-263645-wupre5uj	183	9	-	-	JJ
cord-263645-wupre5uj	183	10	linking	linking	NN
cord-263645-wupre5uj	183	11	and	and	CC
cord-263645-wupre5uj	183	12	isolation	isolation	NN
cord-263645-wupre5uj	183	13	by	by	IN
cord-263645-wupre5uj	183	14	pull	pull	NN
cord-263645-wupre5uj	183	15	down	down	RP
cord-263645-wupre5uj	183	16	(	(	-LRB-
cord-263645-wupre5uj	183	17	Chem	Chem	NNP
cord-263645-wupre5uj	183	18	-	-	HYPH
cord-263645-wupre5uj	183	19	CLIP	CLIP	NNP
cord-263645-wupre5uj	183	20	)	)	-RRB-
cord-263645-wupre5uj	183	21	was	be	VBD
cord-263645-wupre5uj	183	22	utilized	utilize	VBN
cord-263645-wupre5uj	183	23	to	to	TO
cord-263645-wupre5uj	183	24	investigate	investigate	VB
cord-263645-wupre5uj	183	25	proximity	proximity	NN
cord-263645-wupre5uj	183	26	-	-	HYPH
cord-263645-wupre5uj	183	27	based	base	VBN
cord-263645-wupre5uj	183	28	engagement	engagement	NN
cord-263645-wupre5uj	183	29	of	of	IN
cord-263645-wupre5uj	183	30	RNA	RNA	NNP
cord-263645-wupre5uj	183	31	(	(	-LRB-
cord-263645-wupre5uj	183	32	86	86	CD
cord-263645-wupre5uj	183	33	)	)	-RRB-
cord-263645-wupre5uj	183	34	.	.	.
cord-263645-wupre5uj	184	1	In	in	IN
cord-263645-wupre5uj	184	2	this	this	DT
cord-263645-wupre5uj	184	3	method	method	NN
cord-263645-wupre5uj	184	4	,	,	,
cord-263645-wupre5uj	184	5	the	the	DT
cord-263645-wupre5uj	184	6	ligand	ligand	NN
cord-263645-wupre5uj	184	7	is	be	VBZ
cord-263645-wupre5uj	184	8	appended	append	VBN
cord-263645-wupre5uj	184	9	with	with	IN
cord-263645-wupre5uj	184	10	a	a	DT
cord-263645-wupre5uj	184	11	nucleic	nucleic	JJ
cord-263645-wupre5uj	184	12	-	-	HYPH
cord-263645-wupre5uj	184	13	acid	acid	NN
cord-263645-wupre5uj	184	14	reactive	reactive	JJ
cord-263645-wupre5uj	184	15	module	module	NN
cord-263645-wupre5uj	184	16	(	(	-LRB-
cord-263645-wupre5uj	184	17	e.g.	e.g.	IN
cord-263645-wupre5uj	184	18	chlorambucil	chlorambucil	NNP
cord-263645-wupre5uj	184	19	)	)	-RRB-
cord-263645-wupre5uj	184	20	and	and	CC
cord-263645-wupre5uj	184	21	a	a	DT
cord-263645-wupre5uj	184	22	biotin	biotin	NN
cord-263645-wupre5uj	184	23	purification	purification	NN
cord-263645-wupre5uj	184	24	tag	tag	NN
cord-263645-wupre5uj	184	25	.	.	.
cord-263645-wupre5uj	185	1	After	after	IN
cord-263645-wupre5uj	185	2	incubating	incubate	VBG
cord-263645-wupre5uj	185	3	cells	cell	NNS
cord-263645-wupre5uj	185	4	with	with	IN
cord-263645-wupre5uj	185	5	the	the	DT
cord-263645-wupre5uj	185	6	modified	modify	VBN
cord-263645-wupre5uj	185	7	ligand	ligand	NN
cord-263645-wupre5uj	185	8	,	,	,
cord-263645-wupre5uj	185	9	the	the	DT
cord-263645-wupre5uj	185	10	cells	cell	NNS
cord-263645-wupre5uj	185	11	are	be	VBP
cord-263645-wupre5uj	185	12	lysed	lyse	VBN
cord-263645-wupre5uj	185	13	,	,	,
cord-263645-wupre5uj	185	14	the	the	DT
cord-263645-wupre5uj	185	15	ligand	ligand	NN
cord-263645-wupre5uj	185	16	is	be	VBZ
cord-263645-wupre5uj	185	17	captured	capture	VBN
cord-263645-wupre5uj	185	18	by	by	IN
cord-263645-wupre5uj	185	19	streptavidin	streptavidin	NNP
cord-263645-wupre5uj	185	20	beads	bead	NNS
cord-263645-wupre5uj	185	21	,	,	,
cord-263645-wupre5uj	185	22	and	and	CC
cord-263645-wupre5uj	185	23	the	the	DT
cord-263645-wupre5uj	185	24	bound	bound	JJ
cord-263645-wupre5uj	185	25	targets	target	NNS
cord-263645-wupre5uj	185	26	are	be	VBP
cord-263645-wupre5uj	185	27	characterized	characterize	VBN
cord-263645-wupre5uj	185	28	by	by	IN
cord-263645-wupre5uj	185	29	qRT	qRT	NNP
cord-263645-wupre5uj	185	30	-	-	HYPH
cord-263645-wupre5uj	185	31	PCR	PCR	NNP
cord-263645-wupre5uj	185	32	or	or	CC
cord-263645-wupre5uj	185	33	RNA	RNA	NNP
cord-263645-wupre5uj	185	34	-	-	HYPH
cord-263645-wupre5uj	185	35	seq	seq	NNP
cord-263645-wupre5uj	185	36	.	.	.
cord-263645-wupre5uj	186	1	This	this	DT
cord-263645-wupre5uj	186	2	strategy	strategy	NN
cord-263645-wupre5uj	186	3	as	as	RB
cord-263645-wupre5uj	186	4	well	well	RB
cord-263645-wupre5uj	186	5	as	as	IN
cord-263645-wupre5uj	186	6	competitive	competitive	JJ
cord-263645-wupre5uj	186	7	Chem	Chem	NNP
cord-263645-wupre5uj	186	8	-	-	HYPH
cord-263645-wupre5uj	186	9	CLIP	CLIP	NNP
cord-263645-wupre5uj	186	10	(	(	-LRB-
cord-263645-wupre5uj	186	11	86	86	CD
cord-263645-wupre5uj	186	12	)	)	-RRB-
cord-263645-wupre5uj	186	13	were	be	VBD
cord-263645-wupre5uj	186	14	used	use	VBN
cord-263645-wupre5uj	186	15	to	to	TO
cord-263645-wupre5uj	186	16	characterize	characterize	VB
cord-263645-wupre5uj	186	17	onand	onand	PRP$
cord-263645-wupre5uj	186	18	off	off	IN
cord-263645-wupre5uj	186	19	-	-	HYPH
cord-263645-wupre5uj	186	20	target	target	NN
cord-263645-wupre5uj	186	21	engagement	engagement	NN
cord-263645-wupre5uj	186	22	of	of	IN
cord-263645-wupre5uj	186	23	ligands	ligand	NNS
cord-263645-wupre5uj	186	24	that	that	WDT
cord-263645-wupre5uj	186	25	modulate	modulate	VBP
cord-263645-wupre5uj	186	26	repeat	repeat	NN
cord-263645-wupre5uj	186	27	expansions	expansion	NNS
cord-263645-wupre5uj	186	28	(	(	-LRB-
cord-263645-wupre5uj	186	29	45	45	CD
cord-263645-wupre5uj	186	30	,	,	,
cord-263645-wupre5uj	186	31	84	84	CD
cord-263645-wupre5uj	186	32	,	,	,
cord-263645-wupre5uj	186	33	85	85	CD
cord-263645-wupre5uj	186	34	,	,	,
cord-263645-wupre5uj	186	35	87	87	CD
cord-263645-wupre5uj	186	36	)	)	-RRB-
cord-263645-wupre5uj	187	1	and	and	CC
cord-263645-wupre5uj	187	2	miRNAs	miRNAs	NNP
cord-263645-wupre5uj	187	3	(	(	-LRB-
cord-263645-wupre5uj	187	4	16	16	CD
cord-263645-wupre5uj	187	5	,	,	,
cord-263645-wupre5uj	187	6	17	17	CD
cord-263645-wupre5uj	187	7	,	,	,
cord-263645-wupre5uj	187	8	60	60	CD
cord-263645-wupre5uj	187	9	)	)	-RRB-
cord-263645-wupre5uj	187	10	.	.	.
cord-263645-wupre5uj	188	1	In	in	IN
cord-263645-wupre5uj	188	2	another	another	DT
cord-263645-wupre5uj	188	3	study	study	NN
cord-263645-wupre5uj	188	4	,	,	,
cord-263645-wupre5uj	188	5	dual	dual	JJ
cord-263645-wupre5uj	188	6	luciferase	luciferase	NN
cord-263645-wupre5uj	188	7	reporter	reporter	NN
cord-263645-wupre5uj	188	8	assays	assay	NNS
cord-263645-wupre5uj	188	9	were	be	VBD
cord-263645-wupre5uj	188	10	utilized	utilize	VBN
cord-263645-wupre5uj	188	11	to	to	TO
cord-263645-wupre5uj	188	12	compare	compare	VB
cord-263645-wupre5uj	188	13	ligand	ligand	NN
cord-263645-wupre5uj	188	14	binding	binding	NN
cord-263645-wupre5uj	188	15	to	to	IN
cord-263645-wupre5uj	188	16	four	four	CD
cord-263645-wupre5uj	188	17	G	g	NN
cord-263645-wupre5uj	188	18	-	-	HYPH
cord-263645-wupre5uj	188	19	quadruplex	quadruplex	NN
cord-263645-wupre5uj	188	20	structures	structure	NNS
cord-263645-wupre5uj	188	21	,	,	,
cord-263645-wupre5uj	188	22	including	include	VBG
cord-263645-wupre5uj	188	23	the	the	DT
cord-263645-wupre5uj	188	24	RNA	RNA	NNP
cord-263645-wupre5uj	188	25	of	of	IN
cord-263645-wupre5uj	188	26	interest	interest	NN
cord-263645-wupre5uj	188	27	and	and	CC
cord-263645-wupre5uj	188	28	three	three	CD
cord-263645-wupre5uj	188	29	other	other	JJ
cord-263645-wupre5uj	188	30	regulatory	regulatory	JJ
cord-263645-wupre5uj	188	31	RNAs	rna	NNS
cord-263645-wupre5uj	188	32	(	(	-LRB-
cord-263645-wupre5uj	188	33	44	44	CD
cord-263645-wupre5uj	188	34	)	)	-RRB-
cord-263645-wupre5uj	188	35	.	.	.
cord-263645-wupre5uj	189	1	This	this	DT
cord-263645-wupre5uj	189	2	study	study	NN
cord-263645-wupre5uj	189	3	was	be	VBD
cord-263645-wupre5uj	189	4	one	one	CD
cord-263645-wupre5uj	189	5	of	of	IN
cord-263645-wupre5uj	189	6	few	few	JJ
cord-263645-wupre5uj	189	7	examples	example	NNS
cord-263645-wupre5uj	189	8	in	in	IN
cord-263645-wupre5uj	189	9	which	which	WDT
cord-263645-wupre5uj	189	10	selectivity	selectivity	NN
cord-263645-wupre5uj	189	11	within	within	IN
cord-263645-wupre5uj	189	12	a	a	DT
cord-263645-wupre5uj	189	13	target	target	NN
cord-263645-wupre5uj	189	14	family	family	NN
cord-263645-wupre5uj	189	15	was	be	VBD
cord-263645-wupre5uj	189	16	assessed	assess	VBN
cord-263645-wupre5uj	189	17	in	in	IN
cord-263645-wupre5uj	189	18	cell	cell	NN
cord-263645-wupre5uj	189	19	culture	culture	NN
cord-263645-wupre5uj	189	20	.	.	.
cord-263645-wupre5uj	190	1	Various	various	JJ
cord-263645-wupre5uj	190	2	controls	control	NNS
cord-263645-wupre5uj	190	3	were	be	VBD
cord-263645-wupre5uj	190	4	also	also	RB
cord-263645-wupre5uj	190	5	used	use	VBN
cord-263645-wupre5uj	190	6	to	to	TO
cord-263645-wupre5uj	190	7	evaluate	evaluate	VB
cord-263645-wupre5uj	190	8	on	on	IN
cord-263645-wupre5uj	190	9	-	-	HYPH
cord-263645-wupre5uj	190	10	target	target	NN
cord-263645-wupre5uj	190	11	effects	effect	NNS
cord-263645-wupre5uj	190	12	.	.	.
cord-263645-wupre5uj	191	1	For	for	IN
cord-263645-wupre5uj	191	2	example	example	NN
cord-263645-wupre5uj	191	3	,	,	,
cord-263645-wupre5uj	191	4	the	the	DT
cord-263645-wupre5uj	191	5	impacts	impact	NNS
cord-263645-wupre5uj	191	6	of	of	IN
cord-263645-wupre5uj	191	7	chemical	chemical	NN
cord-263645-wupre5uj	191	8	probes	probe	NNS
cord-263645-wupre5uj	191	9	have	have	VBP
cord-263645-wupre5uj	191	10	been	be	VBN
cord-263645-wupre5uj	191	11	analyzed	analyze	VBN
cord-263645-wupre5uj	191	12	following	follow	VBG
cord-263645-wupre5uj	191	13	siRNA	siRNA	NNP
cord-263645-wupre5uj	191	14	knockdown	knockdown	NN
cord-263645-wupre5uj	191	15	of	of	IN
cord-263645-wupre5uj	191	16	FOXO1	FOXO1	NNP
cord-263645-wupre5uj	191	17	mRNA	mrna	NN
cord-263645-wupre5uj	191	18	(	(	-LRB-
cord-263645-wupre5uj	191	19	59	59	CD
cord-263645-wupre5uj	191	20	)	)	-RRB-
cord-263645-wupre5uj	191	21	and	and	CC
cord-263645-wupre5uj	191	22	following	follow	VBG
cord-263645-wupre5uj	191	23	inhibition	inhibition	NN
cord-263645-wupre5uj	191	24	of	of	IN
cord-263645-wupre5uj	191	25	the	the	DT
cord-263645-wupre5uj	191	26	mTOR	mTOR	NNP
cord-263645-wupre5uj	191	27	signaling	signal	VBG
cord-263645-wupre5uj	191	28	pathway	pathway	NN
cord-263645-wupre5uj	191	29	modulated	modulate	VBN
cord-263645-wupre5uj	191	30	by	by	IN
cord-263645-wupre5uj	191	31	miRNA-544	mirna-544	JJ
cord-263645-wupre5uj	191	32	(	(	-LRB-
cord-263645-wupre5uj	191	33	61	61	CD
cord-263645-wupre5uj	191	34	)	)	-RRB-
cord-263645-wupre5uj	191	35	.	.	.
cord-263645-wupre5uj	192	1	Another	another	DT
cord-263645-wupre5uj	192	2	example	example	NN
cord-263645-wupre5uj	192	3	overexpressed	overexpresse	VBD
cord-263645-wupre5uj	192	4	miRNA-210	mirna-210	NN
cord-263645-wupre5uj	192	5	and	and	CC
cord-263645-wupre5uj	192	6	assessed	assess	VBD
cord-263645-wupre5uj	192	7	the	the	DT
cord-263645-wupre5uj	192	8	effect	effect	NN
cord-263645-wupre5uj	192	9	of	of	IN
cord-263645-wupre5uj	192	10	the	the	DT
cord-263645-wupre5uj	192	11	chemical	chemical	NN
cord-263645-wupre5uj	192	12	probe	probe	NN
cord-263645-wupre5uj	192	13	on	on	IN
cord-263645-wupre5uj	192	14	the	the	DT
cord-263645-wupre5uj	192	15	phenotype	phenotype	NN
cord-263645-wupre5uj	192	16	(	(	-LRB-
cord-263645-wupre5uj	192	17	16	16	CD
cord-263645-wupre5uj	192	18	)	)	-RRB-
cord-263645-wupre5uj	192	19	.	.	.
cord-263645-wupre5uj	193	1	Likewise	likewise	RB
cord-263645-wupre5uj	193	2	,	,	,
cord-263645-wupre5uj	193	3	a	a	DT
cord-263645-wupre5uj	193	4	ligand	ligand	NN
cord-263645-wupre5uj	193	5	targeting	target	VBG
cord-263645-wupre5uj	193	6	r(CUG	r(cug	CD
cord-263645-wupre5uj	193	7	)	)	-RRB-
cord-263645-wupre5uj	193	8	exp	exp	NN
cord-263645-wupre5uj	193	9	was	be	VBD
cord-263645-wupre5uj	193	10	tested	test	VBN
cord-263645-wupre5uj	193	11	with	with	IN
cord-263645-wupre5uj	193	12	the	the	DT
cord-263645-wupre5uj	193	13	RNA	RNA	NNP
cord-263645-wupre5uj	193	14	under	under	IN
cord-263645-wupre5uj	193	15	conditional	conditional	JJ
cord-263645-wupre5uj	193	16	expression	expression	NN
cord-263645-wupre5uj	193	17	(	(	-LRB-
cord-263645-wupre5uj	193	18	88	88	CD
cord-263645-wupre5uj	193	19	)	)	-RRB-
cord-263645-wupre5uj	193	20	.	.	.
cord-263645-wupre5uj	194	1	Another	another	DT
cord-263645-wupre5uj	194	2	notable	notable	JJ
cord-263645-wupre5uj	194	3	example	example	NN
cord-263645-wupre5uj	194	4	used	use	VBD
cord-263645-wupre5uj	194	5	RNA	rna	NN
cord-263645-wupre5uj	194	6	immunoprecipitation	immunoprecipitation	NN
cord-263645-wupre5uj	194	7	(	(	-LRB-
cord-263645-wupre5uj	194	8	RIP	rip	NN
cord-263645-wupre5uj	194	9	)	)	-RRB-
cord-263645-wupre5uj	194	10	to	to	TO
cord-263645-wupre5uj	194	11	detect	detect	VB
cord-263645-wupre5uj	194	12	RNA	RNA	NNP
cord-263645-wupre5uj	194	13	-	-	HYPH
cord-263645-wupre5uj	194	14	binding	binding	NN
cord-263645-wupre5uj	194	15	at	at	IN
cord-263645-wupre5uj	194	16	increasing	increase	VBG
cord-263645-wupre5uj	194	17	concentrations	concentration	NNS
cord-263645-wupre5uj	194	18	of	of	IN
cord-263645-wupre5uj	194	19	ligand	ligand	NN
cord-263645-wupre5uj	194	20	and	and	CC
cord-263645-wupre5uj	194	21	identified	identify	VBD
cord-263645-wupre5uj	194	22	a	a	DT
cord-263645-wupre5uj	194	23	dosedependent	dosedependent	NN
cord-263645-wupre5uj	194	24	response	response	NN
cord-263645-wupre5uj	194	25	(	(	-LRB-
cord-263645-wupre5uj	194	26	19	19	CD
cord-263645-wupre5uj	194	27	)	)	-RRB-
cord-263645-wupre5uj	194	28	.	.	.
cord-263645-wupre5uj	195	1	For	for	IN
cord-263645-wupre5uj	195	2	precipitation	precipitation	NN
cord-263645-wupre5uj	195	3	,	,	,
cord-263645-wupre5uj	195	4	a	a	DT
cord-263645-wupre5uj	195	5	G	G	NNP
cord-263645-wupre5uj	195	6	-	-	HYPH
cord-263645-wupre5uj	195	7	quadruplex	quadruplex	NN
cord-263645-wupre5uj	195	8	specific	specific	JJ
cord-263645-wupre5uj	195	9	antibody	antibody	NN
cord-263645-wupre5uj	195	10	,	,	,
cord-263645-wupre5uj	195	11	BG4	BG4	NNP
cord-263645-wupre5uj	195	12	,	,	,
cord-263645-wupre5uj	195	13	was	be	VBD
cord-263645-wupre5uj	195	14	utilized	utilize	VBN
cord-263645-wupre5uj	195	15	and	and	CC
cord-263645-wupre5uj	195	16	the	the	DT
cord-263645-wupre5uj	195	17	complex	complex	NN
cord-263645-wupre5uj	195	18	was	be	VBD
cord-263645-wupre5uj	195	19	characterized	characterize	VBN
cord-263645-wupre5uj	195	20	by	by	IN
cord-263645-wupre5uj	195	21	two	two	CD
cord-263645-wupre5uj	195	22	complementary	complementary	JJ
cord-263645-wupre5uj	195	23	methods	method	NNS
cord-263645-wupre5uj	195	24	:	:	:
cord-263645-wupre5uj	195	25	dot	dot	NN
cord-263645-wupre5uj	195	26	blotting	blotting	NN
cord-263645-wupre5uj	195	27	and	and	CC
cord-263645-wupre5uj	195	28	qRT	qRT	NNP
cord-263645-wupre5uj	195	29	-	-	HYPH
cord-263645-wupre5uj	195	30	PCR	PCR	NNP
cord-263645-wupre5uj	195	31	.	.	.
cord-263645-wupre5uj	196	1	Another	another	DT
cord-263645-wupre5uj	196	2	important	important	JJ
cord-263645-wupre5uj	196	3	control	control	NN
cord-263645-wupre5uj	196	4	,	,	,
cord-263645-wupre5uj	196	5	particularly	particularly	RB
cord-263645-wupre5uj	196	6	for	for	IN
cord-263645-wupre5uj	196	7	human	human	JJ
cord-263645-wupre5uj	196	8	systems	system	NNS
cord-263645-wupre5uj	196	9	,	,	,
cord-263645-wupre5uj	196	10	was	be	VBD
cord-263645-wupre5uj	196	11	to	to	TO
cord-263645-wupre5uj	196	12	replicate	replicate	VB
cord-263645-wupre5uj	196	13	on	on	IN
cord-263645-wupre5uj	196	14	-	-	HYPH
cord-263645-wupre5uj	196	15	target	target	NN
cord-263645-wupre5uj	196	16	effects	effect	NNS
cord-263645-wupre5uj	196	17	in	in	IN
cord-263645-wupre5uj	196	18	at	at	RB
cord-263645-wupre5uj	196	19	least	least	RBS
cord-263645-wupre5uj	196	20	two	two	CD
cord-263645-wupre5uj	196	21	cell	cell	NN
cord-263645-wupre5uj	196	22	lines	line	NNS
cord-263645-wupre5uj	196	23	,	,	,
cord-263645-wupre5uj	196	24	though	though	IN
cord-263645-wupre5uj	196	25	this	this	DT
cord-263645-wupre5uj	196	26	control	control	NN
cord-263645-wupre5uj	196	27	was	be	VBD
cord-263645-wupre5uj	196	28	performed	perform	VBN
cord-263645-wupre5uj	196	29	for	for	IN
cord-263645-wupre5uj	196	30	only	only	RB
cord-263645-wupre5uj	196	31	a	a	DT
cord-263645-wupre5uj	196	32	limited	limited	JJ
cord-263645-wupre5uj	196	33	number	number	NN
cord-263645-wupre5uj	196	34	of	of	IN
cord-263645-wupre5uj	196	35	chemical	chemical	NN
cord-263645-wupre5uj	196	36	probes	probe	NNS
cord-263645-wupre5uj	196	37	(	(	-LRB-
cord-263645-wupre5uj	196	38	44	44	CD
cord-263645-wupre5uj	196	39	,	,	,
cord-263645-wupre5uj	196	40	53	53	CD
cord-263645-wupre5uj	196	41	,	,	,
cord-263645-wupre5uj	196	42	47	47	CD
cord-263645-wupre5uj	196	43	,	,	,
cord-263645-wupre5uj	196	44	81	81	CD
cord-263645-wupre5uj	196	45	,	,	,
cord-263645-wupre5uj	196	46	84	84	CD
cord-263645-wupre5uj	196	47	)	)	-RRB-
cord-263645-wupre5uj	196	48	.	.	.
cord-263645-wupre5uj	197	1	For	for	IN
cord-263645-wupre5uj	197	2	many	many	JJ
cord-263645-wupre5uj	197	3	years	year	NNS
cord-263645-wupre5uj	197	4	,	,	,
cord-263645-wupre5uj	197	5	RNA	RNA	NNP
cord-263645-wupre5uj	197	6	has	have	VBZ
cord-263645-wupre5uj	197	7	been	be	VBN
cord-263645-wupre5uj	197	8	labeled	label	VBN
cord-263645-wupre5uj	197	9	as	as	IN
cord-263645-wupre5uj	197	10	'	'	``
cord-263645-wupre5uj	197	11	undruggable	undruggable	JJ
cord-263645-wupre5uj	197	12	'	'	''
cord-263645-wupre5uj	197	13	or	or	CC
cord-263645-wupre5uj	197	14	'	'	``
cord-263645-wupre5uj	197	15	impossible	impossible	JJ
cord-263645-wupre5uj	197	16	to	to	TO
cord-263645-wupre5uj	197	17	probe	probe	VB
cord-263645-wupre5uj	197	18	selectively	selectively	RB
cord-263645-wupre5uj	197	19	'	'	''
cord-263645-wupre5uj	197	20	;	;	:
cord-263645-wupre5uj	197	21	however	however	RB
cord-263645-wupre5uj	197	22	,	,	,
cord-263645-wupre5uj	197	23	the	the	DT
cord-263645-wupre5uj	197	24	reports	report	NNS
cord-263645-wupre5uj	197	25	described	describe	VBN
cord-263645-wupre5uj	197	26	herein	herein	RB
cord-263645-wupre5uj	197	27	demonstrate	demonstrate	VB
cord-263645-wupre5uj	197	28	the	the	DT
cord-263645-wupre5uj	197	29	substantial	substantial	JJ
cord-263645-wupre5uj	197	30	progress	progress	NN
cord-263645-wupre5uj	197	31	that	that	WDT
cord-263645-wupre5uj	197	32	has	have	VBZ
cord-263645-wupre5uj	197	33	been	be	VBN
cord-263645-wupre5uj	197	34	achieved	achieve	VBN
cord-263645-wupre5uj	197	35	in	in	IN
cord-263645-wupre5uj	197	36	the	the	DT
cord-263645-wupre5uj	197	37	past	past	JJ
cord-263645-wupre5uj	197	38	four	four	CD
cord-263645-wupre5uj	197	39	years	year	NNS
cord-263645-wupre5uj	197	40	.	.	.
cord-263645-wupre5uj	198	1	This	this	DT
cord-263645-wupre5uj	198	2	includes	include	VBZ
cord-263645-wupre5uj	198	3	the	the	DT
cord-263645-wupre5uj	198	4	development	development	NN
cord-263645-wupre5uj	198	5	of	of	IN
cord-263645-wupre5uj	198	6	chemical	chemical	JJ
cord-263645-wupre5uj	198	7	probes	probe	NNS
cord-263645-wupre5uj	198	8	for	for	IN
cord-263645-wupre5uj	198	9	33	33	CD
cord-263645-wupre5uj	198	10	unique	unique	JJ
cord-263645-wupre5uj	198	11	RNA	RNA	NNP
cord-263645-wupre5uj	198	12	elements	element	NNS
cord-263645-wupre5uj	198	13	,	,	,
cord-263645-wupre5uj	198	14	though	though	IN
cord-263645-wupre5uj	198	15	the	the	DT
cord-263645-wupre5uj	198	16	number	number	NN
cord-263645-wupre5uj	198	17	of	of	IN
cord-263645-wupre5uj	198	18	'	'	``
cord-263645-wupre5uj	198	19	targetable	targetable	JJ
cord-263645-wupre5uj	198	20	'	'	''
cord-263645-wupre5uj	198	21	RNA	RNA	NNP
cord-263645-wupre5uj	198	22	elements	element	NNS
cord-263645-wupre5uj	198	23	is	be	VBZ
cord-263645-wupre5uj	198	24	certain	certain	JJ
cord-263645-wupre5uj	198	25	to	to	TO
cord-263645-wupre5uj	198	26	vastly	vastly	RB
cord-263645-wupre5uj	198	27	exceed	exceed	VB
cord-263645-wupre5uj	198	28	this	this	DT
cord-263645-wupre5uj	198	29	list	list	NN
cord-263645-wupre5uj	198	30	(	(	-LRB-
cord-263645-wupre5uj	198	31	5	5	CD
cord-263645-wupre5uj	198	32	,	,	,
cord-263645-wupre5uj	198	33	6	6	CD
cord-263645-wupre5uj	198	34	,	,	,
cord-263645-wupre5uj	198	35	23	23	CD
cord-263645-wupre5uj	198	36	,	,	,
cord-263645-wupre5uj	198	37	89	89	CD
cord-263645-wupre5uj	198	38	)	)	-RRB-
cord-263645-wupre5uj	198	39	.	.	.
cord-263645-wupre5uj	199	1	Those	those	DT
cord-263645-wupre5uj	199	2	in	in	IN
cord-263645-wupre5uj	199	3	Archaea	Archaea	NNP
cord-263645-wupre5uj	199	4	,	,	,
cord-263645-wupre5uj	199	5	for	for	IN
cord-263645-wupre5uj	199	6	example	example	NN
cord-263645-wupre5uj	199	7	,	,	,
cord-263645-wupre5uj	199	8	are	be	VBP
cord-263645-wupre5uj	199	9	unrepresented	unrepresented	JJ
cord-263645-wupre5uj	199	10	in	in	IN
cord-263645-wupre5uj	199	11	reports	report	NNS
cord-263645-wupre5uj	199	12	of	of	IN
cord-263645-wupre5uj	199	13	RNAtargeted	rnatargeted	JJ
cord-263645-wupre5uj	199	14	chemical	chemical	NN
cord-263645-wupre5uj	199	15	probes	probe	NNS
cord-263645-wupre5uj	199	16	,	,	,
cord-263645-wupre5uj	199	17	despite	despite	IN
cord-263645-wupre5uj	199	18	the	the	DT
cord-263645-wupre5uj	199	19	established	establish	VBN
cord-263645-wupre5uj	199	20	importance	importance	NN
cord-263645-wupre5uj	199	21	of	of	IN
cord-263645-wupre5uj	199	22	small	small	JJ
cord-263645-wupre5uj	199	23	regulatory	regulatory	JJ
cord-263645-wupre5uj	199	24	RNAs	rna	NNS
cord-263645-wupre5uj	199	25	in	in	IN
cord-263645-wupre5uj	199	26	archaea	archaea	NNP
cord-263645-wupre5uj	199	27	metabolism	metabolism	NN
cord-263645-wupre5uj	199	28	,	,	,
cord-263645-wupre5uj	199	29	morphology	morphology	NN
cord-263645-wupre5uj	199	30	,	,	,
cord-263645-wupre5uj	199	31	and	and	CC
cord-263645-wupre5uj	199	32	adaption	adaption	NN
cord-263645-wupre5uj	199	33	to	to	IN
cord-263645-wupre5uj	199	34	extreme	extreme	JJ
cord-263645-wupre5uj	199	35	conditions	condition	NNS
cord-263645-wupre5uj	199	36	(	(	-LRB-
cord-263645-wupre5uj	199	37	90	90	CD
cord-263645-wupre5uj	199	38	,	,	,
cord-263645-wupre5uj	199	39	91	91	CD
cord-263645-wupre5uj	199	40	)	)	-RRB-
cord-263645-wupre5uj	199	41	.	.	.
cord-263645-wupre5uj	200	1	Furthermore	furthermore	RB
cord-263645-wupre5uj	200	2	,	,	,
cord-263645-wupre5uj	200	3	there	there	EX
cord-263645-wupre5uj	200	4	are	be	VBP
cord-263645-wupre5uj	200	5	several	several	JJ
cord-263645-wupre5uj	200	6	RNAs	rna	NNS
cord-263645-wupre5uj	200	7	implicated	implicate	VBN
cord-263645-wupre5uj	200	8	in	in	IN
cord-263645-wupre5uj	200	9	diseases	disease	NNS
cord-263645-wupre5uj	200	10	for	for	IN
cord-263645-wupre5uj	200	11	which	which	WDT
cord-263645-wupre5uj	200	12	novel	novel	JJ
cord-263645-wupre5uj	200	13	treatment	treatment	NN
cord-263645-wupre5uj	200	14	strategies	strategy	NNS
cord-263645-wupre5uj	200	15	are	be	VBP
cord-263645-wupre5uj	200	16	needed	need	VBN
cord-263645-wupre5uj	200	17	,	,	,
cord-263645-wupre5uj	200	18	including	include	VBG
cord-263645-wupre5uj	200	19	insect	insect	NN
cord-263645-wupre5uj	200	20	-	-	HYPH
cord-263645-wupre5uj	200	21	borne	bear	VBN
cord-263645-wupre5uj	200	22	viruses	virus	NNS
cord-263645-wupre5uj	200	23	(	(	-LRB-
cord-263645-wupre5uj	200	24	23	23	CD
cord-263645-wupre5uj	200	25	)	)	-RRB-
cord-263645-wupre5uj	200	26	,	,	,
cord-263645-wupre5uj	200	27	genetic	genetic	JJ
cord-263645-wupre5uj	200	28	disorders	disorder	NNS
cord-263645-wupre5uj	200	29	(	(	-LRB-
cord-263645-wupre5uj	200	30	92	92	CD
cord-263645-wupre5uj	200	31	)	)	-RRB-
cord-263645-wupre5uj	200	32	,	,	,
cord-263645-wupre5uj	200	33	and	and	CC
cord-263645-wupre5uj	200	34	metastatic	metastatic	JJ
cord-263645-wupre5uj	200	35	cancers	cancer	NNS
cord-263645-wupre5uj	200	36	(	(	-LRB-
cord-263645-wupre5uj	200	37	5,6	5,6	CD
cord-263645-wupre5uj	200	38	)	)	-RRB-
cord-263645-wupre5uj	200	39	as	as	RB
cord-263645-wupre5uj	200	40	well	well	RB
cord-263645-wupre5uj	200	41	as	as	IN
cord-263645-wupre5uj	200	42	bacterial	bacterial	JJ
cord-263645-wupre5uj	200	43	targets	target	NNS
cord-263645-wupre5uj	200	44	amid	amid	IN
cord-263645-wupre5uj	200	45	the	the	DT
cord-263645-wupre5uj	200	46	antibiotic	antibiotic	JJ
cord-263645-wupre5uj	200	47	-	-	HYPH
cord-263645-wupre5uj	200	48	resistance	resistance	NN
cord-263645-wupre5uj	200	49	crisis	crisis	NN
cord-263645-wupre5uj	200	50	(	(	-LRB-
cord-263645-wupre5uj	200	51	89	89	CD
cord-263645-wupre5uj	200	52	,	,	,
cord-263645-wupre5uj	200	53	93	93	CD
cord-263645-wupre5uj	200	54	)	)	-RRB-
cord-263645-wupre5uj	200	55	.	.	.
cord-263645-wupre5uj	201	1	There	there	EX
cord-263645-wupre5uj	201	2	are	be	VBP
cord-263645-wupre5uj	201	3	also	also	RB
cord-263645-wupre5uj	201	4	many	many	JJ
cord-263645-wupre5uj	201	5	opportunities	opportunity	NNS
cord-263645-wupre5uj	201	6	for	for	IN
cord-263645-wupre5uj	201	7	RNA	rna	NN
cord-263645-wupre5uj	201	8	-	-	HYPH
cord-263645-wupre5uj	201	9	targeting	targeting	NN
cord-263645-wupre5uj	201	10	in	in	IN
cord-263645-wupre5uj	201	11	fungal	fungal	JJ
cord-263645-wupre5uj	201	12	systems	system	NNS
cord-263645-wupre5uj	201	13	(	(	-LRB-
cord-263645-wupre5uj	201	14	94	94	CD
cord-263645-wupre5uj	201	15	)	)	-RRB-
cord-263645-wupre5uj	201	16	,	,	,
cord-263645-wupre5uj	201	17	especially	especially	RB
cord-263645-wupre5uj	201	18	as	as	IN
cord-263645-wupre5uj	201	19	fungal	fungal	JJ
cord-263645-wupre5uj	201	20	infections	infection	NNS
cord-263645-wupre5uj	201	21	are	be	VBP
cord-263645-wupre5uj	201	22	experiencing	experience	VBG
cord-263645-wupre5uj	201	23	a	a	DT
cord-263645-wupre5uj	201	24	rise	rise	NN
cord-263645-wupre5uj	201	25	in	in	IN
cord-263645-wupre5uj	201	26	cases	case	NNS
cord-263645-wupre5uj	201	27	and	and	CC
cord-263645-wupre5uj	201	28	a	a	DT
cord-263645-wupre5uj	201	29	therapeutic	therapeutic	JJ
cord-263645-wupre5uj	201	30	plateau	plateau	NN
cord-263645-wupre5uj	201	31	(	(	-LRB-
cord-263645-wupre5uj	201	32	95	95	CD
cord-263645-wupre5uj	201	33	)	)	-RRB-
cord-263645-wupre5uj	201	34	.	.	.
cord-263645-wupre5uj	202	1	Fundamentally	fundamentally	RB
cord-263645-wupre5uj	202	2	,	,	,
cord-263645-wupre5uj	202	3	the	the	DT
cord-263645-wupre5uj	202	4	development	development	NN
cord-263645-wupre5uj	202	5	of	of	IN
cord-263645-wupre5uj	202	6	chemical	chemical	JJ
cord-263645-wupre5uj	202	7	probes	probe	NNS
cord-263645-wupre5uj	202	8	will	will	MD
cord-263645-wupre5uj	202	9	allow	allow	VB
cord-263645-wupre5uj	202	10	for	for	IN
cord-263645-wupre5uj	202	11	the	the	DT
cord-263645-wupre5uj	202	12	rapid	rapid	JJ
cord-263645-wupre5uj	202	13	and	and	CC
cord-263645-wupre5uj	202	14	reversible	reversible	JJ
cord-263645-wupre5uj	202	15	interrogation	interrogation	NN
cord-263645-wupre5uj	202	16	of	of	IN
cord-263645-wupre5uj	202	17	novel	novel	JJ
cord-263645-wupre5uj	202	18	and	and	CC
cord-263645-wupre5uj	202	19	complex	complex	JJ
cord-263645-wupre5uj	202	20	RNA	RNA	NNP
cord-263645-wupre5uj	202	21	biology	biology	NN
cord-263645-wupre5uj	202	22	in	in	IN
cord-263645-wupre5uj	202	23	ways	way	NNS
cord-263645-wupre5uj	202	24	not	not	RB
cord-263645-wupre5uj	202	25	attainable	attainable	JJ
cord-263645-wupre5uj	202	26	by	by	IN
cord-263645-wupre5uj	202	27	knockdown	knockdown	NN
cord-263645-wupre5uj	202	28	and	and	CC
cord-263645-wupre5uj	202	29	genetic	genetic	JJ
cord-263645-wupre5uj	202	30	approaches	approach	NNS
cord-263645-wupre5uj	202	31	(	(	-LRB-
cord-263645-wupre5uj	202	32	74	74	CD
cord-263645-wupre5uj	202	33	)	)	-RRB-
cord-263645-wupre5uj	202	34	.	.	.
cord-263645-wupre5uj	203	1	While	while	IN
cord-263645-wupre5uj	203	2	the	the	DT
cord-263645-wupre5uj	203	3	potential	potential	JJ
cord-263645-wupre5uj	203	4	benefits	benefit	NNS
cord-263645-wupre5uj	203	5	of	of	IN
cord-263645-wupre5uj	203	6	selective	selective	JJ
cord-263645-wupre5uj	203	7	RNA	RNA	NNP
cord-263645-wupre5uj	203	8	targeting	targeting	NN
cord-263645-wupre5uj	203	9	are	be	VBP
cord-263645-wupre5uj	203	10	staggering	staggering	JJ
cord-263645-wupre5uj	203	11	,	,	,
cord-263645-wupre5uj	203	12	approaches	approach	NNS
cord-263645-wupre5uj	203	13	toward	toward	IN
cord-263645-wupre5uj	203	14	chemical	chemical	JJ
cord-263645-wupre5uj	203	15	probe	probe	NN
cord-263645-wupre5uj	203	16	development	development	NN
cord-263645-wupre5uj	203	17	must	must	MD
cord-263645-wupre5uj	203	18	thoughtfully	thoughtfully	RB
cord-263645-wupre5uj	203	19	consider	consider	VB
cord-263645-wupre5uj	203	20	a	a	DT
cord-263645-wupre5uj	203	21	number	number	NN
cord-263645-wupre5uj	203	22	of	of	IN
cord-263645-wupre5uj	203	23	variables	variable	NNS
cord-263645-wupre5uj	203	24	,	,	,
cord-263645-wupre5uj	203	25	including	include	VBG
cord-263645-wupre5uj	203	26	transcript	transcript	NN
cord-263645-wupre5uj	203	27	abundance	abundance	NN
cord-263645-wupre5uj	203	28	and	and	CC
cord-263645-wupre5uj	203	29	tissue	tissue	NN
cord-263645-wupre5uj	203	30	-	-	HYPH
cord-263645-wupre5uj	203	31	specific	specific	JJ
cord-263645-wupre5uj	203	32	expression	expression	NN
cord-263645-wupre5uj	203	33	of	of	IN
cord-263645-wupre5uj	203	34	the	the	DT
cord-263645-wupre5uj	203	35	RNA	RNA	NNP
cord-263645-wupre5uj	203	36	target	target	NN
cord-263645-wupre5uj	203	37	.	.	.
cord-263645-wupre5uj	204	1	By	by	IN
cord-263645-wupre5uj	204	2	total	total	JJ
cord-263645-wupre5uj	204	3	mass	mass	NN
cord-263645-wupre5uj	204	4	and	and	CC
cord-263645-wupre5uj	204	5	number	number	NN
cord-263645-wupre5uj	204	6	of	of	IN
cord-263645-wupre5uj	204	7	molecules	molecule	NNS
cord-263645-wupre5uj	204	8	,	,	,
cord-263645-wupre5uj	204	9	rRNA	rRNA	NNP
cord-263645-wupre5uj	204	10	and	and	CC
cord-263645-wupre5uj	204	11	tRNA	trna	NN
cord-263645-wupre5uj	204	12	account	account	VBP
cord-263645-wupre5uj	204	13	for	for	IN
cord-263645-wupre5uj	204	14	greater	great	JJR
cord-263645-wupre5uj	204	15	than	than	IN
cord-263645-wupre5uj	204	16	90	90	CD
cord-263645-wupre5uj	204	17	%	%	NN
cord-263645-wupre5uj	204	18	of	of	IN
cord-263645-wupre5uj	204	19	total	total	JJ
cord-263645-wupre5uj	204	20	cellular	cellular	JJ
cord-263645-wupre5uj	204	21	RNA	RNA	NNP
cord-263645-wupre5uj	204	22	in	in	IN
cord-263645-wupre5uj	204	23	humans	human	NNS
cord-263645-wupre5uj	204	24	(	(	-LRB-
cord-263645-wupre5uj	204	25	96	96	CD
cord-263645-wupre5uj	204	26	)	)	-RRB-
cord-263645-wupre5uj	204	27	,	,	,
cord-263645-wupre5uj	204	28	and	and	CC
cord-263645-wupre5uj	204	29	thus	thus	RB
cord-263645-wupre5uj	204	30	mRNAs	mrnas	CD
cord-263645-wupre5uj	204	31	and	and	CC
cord-263645-wupre5uj	204	32	other	other	JJ
cord-263645-wupre5uj	204	33	ncRNAs	ncrna	NNS
cord-263645-wupre5uj	204	34	exist	exist	VBP
cord-263645-wupre5uj	204	35	in	in	IN
cord-263645-wupre5uj	204	36	a	a	DT
cord-263645-wupre5uj	204	37	much	much	RB
cord-263645-wupre5uj	204	38	lower	low	JJR
cord-263645-wupre5uj	204	39	abundance	abundance	NN
cord-263645-wupre5uj	204	40	(	(	-LRB-
cord-263645-wupre5uj	204	41	1	1	CD
cord-263645-wupre5uj	204	42	,	,	,
cord-263645-wupre5uj	204	43	96	96	CD
cord-263645-wupre5uj	204	44	,	,	,
cord-263645-wupre5uj	204	45	97	97	CD
cord-263645-wupre5uj	204	46	)	)	-RRB-
cord-263645-wupre5uj	204	47	.	.	.
cord-263645-wupre5uj	205	1	Even	even	RB
cord-263645-wupre5uj	205	2	within	within	IN
cord-263645-wupre5uj	205	3	these	these	DT
cord-263645-wupre5uj	205	4	low	low	JJ
cord-263645-wupre5uj	205	5	abundance	abundance	NN
cord-263645-wupre5uj	205	6	transcripts	transcript	NNS
cord-263645-wupre5uj	205	7	,	,	,
cord-263645-wupre5uj	205	8	copy	copy	NN
cord-263645-wupre5uj	205	9	numbers	number	NNS
cord-263645-wupre5uj	205	10	can	can	MD
cord-263645-wupre5uj	205	11	vary	vary	VB
cord-263645-wupre5uj	205	12	widely	widely	RB
cord-263645-wupre5uj	205	13	within	within	IN
cord-263645-wupre5uj	205	14	and	and	CC
cord-263645-wupre5uj	205	15	across	across	IN
cord-263645-wupre5uj	205	16	cell	cell	NN
cord-263645-wupre5uj	205	17	types	type	NNS
cord-263645-wupre5uj	205	18	with	with	IN
cord-263645-wupre5uj	205	19	reports	report	NNS
cord-263645-wupre5uj	205	20	of	of	IN
cord-263645-wupre5uj	205	21	mRNA	mRNA	NNP
cord-263645-wupre5uj	205	22	levels	level	NNS
cord-263645-wupre5uj	205	23	spanning	span	VBG
cord-263645-wupre5uj	205	24	four	four	CD
cord-263645-wupre5uj	205	25	orders	order	NNS
cord-263645-wupre5uj	205	26	of	of	IN
cord-263645-wupre5uj	205	27	magnitude	magnitude	NN
cord-263645-wupre5uj	205	28	and	and	CC
cord-263645-wupre5uj	205	29	some	some	DT
cord-263645-wupre5uj	205	30	ncRNAs	ncrna	NNS
cord-263645-wupre5uj	205	31	averaging	average	VBG
cord-263645-wupre5uj	205	32	less	less	JJR
cord-263645-wupre5uj	205	33	than	than	IN
cord-263645-wupre5uj	205	34	one	one	CD
cord-263645-wupre5uj	205	35	copy	copy	NN
cord-263645-wupre5uj	205	36	per	per	IN
cord-263645-wupre5uj	205	37	cell	cell	NN
cord-263645-wupre5uj	205	38	(	(	-LRB-
cord-263645-wupre5uj	205	39	1	1	CD
cord-263645-wupre5uj	205	40	,	,	,
cord-263645-wupre5uj	205	41	97	97	CD
cord-263645-wupre5uj	205	42	,	,	,
cord-263645-wupre5uj	205	43	98	98	CD
cord-263645-wupre5uj	205	44	)	)	-RRB-
cord-263645-wupre5uj	205	45	.	.	.
cord-263645-wupre5uj	206	1	A	a	DT
cord-263645-wupre5uj	206	2	direct	direct	JJ
cord-263645-wupre5uj	206	3	impact	impact	NN
cord-263645-wupre5uj	206	4	of	of	IN
cord-263645-wupre5uj	206	5	RNA	RNA	NNP
cord-263645-wupre5uj	206	6	expression	expression	NN
cord-263645-wupre5uj	206	7	levels	level	NNS
cord-263645-wupre5uj	206	8	was	be	VBD
cord-263645-wupre5uj	206	9	recently	recently	RB
cord-263645-wupre5uj	206	10	reported	report	VBN
cord-263645-wupre5uj	206	11	,	,	,
cord-263645-wupre5uj	206	12	in	in	IN
cord-263645-wupre5uj	206	13	which	which	WDT
cord-263645-wupre5uj	206	14	the	the	DT
cord-263645-wupre5uj	206	15	authors	author	NNS
cord-263645-wupre5uj	206	16	proposed	propose	VBD
cord-263645-wupre5uj	206	17	that	that	IN
cord-263645-wupre5uj	206	18	ligand	ligand	NN
cord-263645-wupre5uj	206	19	occupancy	occupancy	NN
cord-263645-wupre5uj	206	20	of	of	IN
cord-263645-wupre5uj	206	21	the	the	DT
cord-263645-wupre5uj	206	22	miRNA	miRNA	NNP
cord-263645-wupre5uj	206	23	target	target	NN
cord-263645-wupre5uj	206	24	was	be	VBD
cord-263645-wupre5uj	206	25	driven	drive	VBN
cord-263645-wupre5uj	206	26	by	by	IN
cord-263645-wupre5uj	206	27	the	the	DT
cord-263645-wupre5uj	206	28	relative	relative	JJ
cord-263645-wupre5uj	206	29	abundance	abundance	NN
cord-263645-wupre5uj	206	30	of	of	IN
cord-263645-wupre5uj	206	31	structurally	structurally	RB
cord-263645-wupre5uj	206	32	similar	similar	JJ
cord-263645-wupre5uj	206	33	RNA	RNA	NNP
cord-263645-wupre5uj	206	34	elements	element	NNS
cord-263645-wupre5uj	206	35	(	(	-LRB-
cord-263645-wupre5uj	206	36	16	16	CD
cord-263645-wupre5uj	206	37	)	)	-RRB-
cord-263645-wupre5uj	206	38	.	.	.
cord-263645-wupre5uj	207	1	RNA	RNA	NNP
cord-263645-wupre5uj	207	2	with	with	IN
cord-263645-wupre5uj	207	3	well	well	RB
cord-263645-wupre5uj	207	4	-	-	HYPH
cord-263645-wupre5uj	207	5	defined	define	VBN
cord-263645-wupre5uj	207	6	function	function	NN
cord-263645-wupre5uj	207	7	and	and	CC
cord-263645-wupre5uj	207	8	that	that	WDT
cord-263645-wupre5uj	207	9	are	be	VBP
cord-263645-wupre5uj	207	10	highly	highly	RB
cord-263645-wupre5uj	207	11	expressed	express	VBN
cord-263645-wupre5uj	207	12	thus	thus	RB
cord-263645-wupre5uj	207	13	represent	represent	VB
cord-263645-wupre5uj	207	14	low	low	RB
cord-263645-wupre5uj	207	15	-	-	HYPH
cord-263645-wupre5uj	207	16	hanging	hang	VBG
cord-263645-wupre5uj	207	17	fruit	fruit	NN
cord-263645-wupre5uj	207	18	within	within	IN
cord-263645-wupre5uj	207	19	the	the	DT
cord-263645-wupre5uj	207	20	field	field	NN
cord-263645-wupre5uj	207	21	(	(	-LRB-
cord-263645-wupre5uj	207	22	6	6	CD
cord-263645-wupre5uj	207	23	,	,	,
cord-263645-wupre5uj	207	24	99	99	CD
cord-263645-wupre5uj	207	25	)	)	-RRB-
cord-263645-wupre5uj	207	26	.	.	.
cord-263645-wupre5uj	208	1	The	the	DT
cord-263645-wupre5uj	208	2	selection	selection	NN
cord-263645-wupre5uj	208	3	of	of	IN
cord-263645-wupre5uj	208	4	a	a	DT
cord-263645-wupre5uj	208	5	library	library	NN
cord-263645-wupre5uj	208	6	and	and	CC
cord-263645-wupre5uj	208	7	primary	primary	JJ
cord-263645-wupre5uj	208	8	screening	screening	NN
cord-263645-wupre5uj	208	9	strategy	strategy	NN
cord-263645-wupre5uj	208	10	is	be	VBZ
cord-263645-wupre5uj	208	11	also	also	RB
cord-263645-wupre5uj	208	12	critical	critical	JJ
cord-263645-wupre5uj	208	13	for	for	IN
cord-263645-wupre5uj	208	14	the	the	DT
cord-263645-wupre5uj	208	15	success	success	NN
cord-263645-wupre5uj	208	16	of	of	IN
cord-263645-wupre5uj	208	17	chemical	chemical	NN
cord-263645-wupre5uj	208	18	probe	probe	NN
cord-263645-wupre5uj	208	19	discovery	discovery	NN
cord-263645-wupre5uj	208	20	.	.	.
cord-263645-wupre5uj	209	1	For	for	IN
cord-263645-wupre5uj	209	2	RNA	RNA	NNP
cord-263645-wupre5uj	209	3	targets	target	NNS
cord-263645-wupre5uj	209	4	with	with	IN
cord-263645-wupre5uj	209	5	known	know	VBN
cord-263645-wupre5uj	209	6	structure	structure	NN
cord-263645-wupre5uj	210	1	and/or	and/or	CC
cord-263645-wupre5uj	210	2	ligands	ligand	NNS
cord-263645-wupre5uj	210	3	,	,	,
cord-263645-wupre5uj	211	1	the	the	DT
cord-263645-wupre5uj	211	2	use	use	NN
cord-263645-wupre5uj	211	3	of	of	IN
cord-263645-wupre5uj	211	4	focused	focused	JJ
cord-263645-wupre5uj	211	5	screening	screening	NN
cord-263645-wupre5uj	211	6	libraries	library	NNS
cord-263645-wupre5uj	211	7	(	(	-LRB-
cord-263645-wupre5uj	211	8	35	35	CD
cord-263645-wupre5uj	211	9	,	,	,
cord-263645-wupre5uj	211	10	36	36	CD
cord-263645-wupre5uj	211	11	)	)	-RRB-
cord-263645-wupre5uj	211	12	has	have	VBZ
cord-263645-wupre5uj	211	13	proven	prove	VBN
cord-263645-wupre5uj	211	14	to	to	TO
cord-263645-wupre5uj	211	15	be	be	VB
cord-263645-wupre5uj	211	16	an	an	DT
cord-263645-wupre5uj	211	17	efficient	efficient	JJ
cord-263645-wupre5uj	211	18	strategy	strategy	NN
cord-263645-wupre5uj	211	19	,	,	,
cord-263645-wupre5uj	211	20	though	though	IN
cord-263645-wupre5uj	211	21	this	this	DT
cord-263645-wupre5uj	211	22	approach	approach	NN
cord-263645-wupre5uj	211	23	generally	generally	RB
cord-263645-wupre5uj	211	24	limits	limit	VBZ
cord-263645-wupre5uj	211	25	the	the	DT
cord-263645-wupre5uj	211	26	chemical	chemical	JJ
cord-263645-wupre5uj	211	27	diversity	diversity	NN
cord-263645-wupre5uj	211	28	of	of	IN
cord-263645-wupre5uj	211	29	the	the	DT
cord-263645-wupre5uj	211	30	library	library	NN
cord-263645-wupre5uj	211	31	.	.	.
cord-263645-wupre5uj	212	1	Advances	advance	NNS
cord-263645-wupre5uj	212	2	such	such	JJ
cord-263645-wupre5uj	212	3	as	as	IN
cord-263645-wupre5uj	212	4	the	the	DT
cord-263645-wupre5uj	212	5	identification	identification	NN
cord-263645-wupre5uj	212	6	of	of	IN
cord-263645-wupre5uj	212	7	more	more	JJR
cord-263645-wupre5uj	212	8	RNA	rna	NN
cord-263645-wupre5uj	212	9	-	-	HYPH
cord-263645-wupre5uj	212	10	privileged	privilege	VBN
cord-263645-wupre5uj	212	11	scaffolds	scaffold	NNS
cord-263645-wupre5uj	212	12	(	(	-LRB-
cord-263645-wupre5uj	212	13	39	39	CD
cord-263645-wupre5uj	212	14	)	)	-RRB-
cord-263645-wupre5uj	212	15	and	and	CC
cord-263645-wupre5uj	212	16	biologically	biologically	RB
cord-263645-wupre5uj	212	17	relevant	relevant	JJ
cord-263645-wupre5uj	212	18	RNA	RNA	NNP
cord-263645-wupre5uj	212	19	chemical	chemical	NN
cord-263645-wupre5uj	212	20	space	space	NN
cord-263645-wupre5uj	212	21	(	(	-LRB-
cord-263645-wupre5uj	212	22	22	22	CD
cord-263645-wupre5uj	212	23	,	,	,
cord-263645-wupre5uj	212	24	100	100	CD
cord-263645-wupre5uj	212	25	)	)	-RRB-
cord-263645-wupre5uj	212	26	will	will	MD
cord-263645-wupre5uj	212	27	facilitate	facilitate	VB
cord-263645-wupre5uj	212	28	the	the	DT
cord-263645-wupre5uj	212	29	discovery	discovery	NN
cord-263645-wupre5uj	212	30	of	of	IN
cord-263645-wupre5uj	212	31	chemical	chemical	JJ
cord-263645-wupre5uj	212	32	probes	probe	NNS
cord-263645-wupre5uj	212	33	for	for	IN
cord-263645-wupre5uj	212	34	additional	additional	JJ
cord-263645-wupre5uj	212	35	RNA	RNA	NNP
cord-263645-wupre5uj	212	36	targets	target	NNS
cord-263645-wupre5uj	212	37	.	.	.
cord-263645-wupre5uj	213	1	These	these	DT
cord-263645-wupre5uj	213	2	efforts	effort	NNS
cord-263645-wupre5uj	213	3	could	could	MD
cord-263645-wupre5uj	213	4	be	be	VB
cord-263645-wupre5uj	213	5	expedited	expedite	VBN
cord-263645-wupre5uj	213	6	by	by	IN
cord-263645-wupre5uj	213	7	additional	additional	JJ
cord-263645-wupre5uj	213	8	fragment	fragment	NN
cord-263645-wupre5uj	213	9	-	-	HYPH
cord-263645-wupre5uj	213	10	or	or	CC
cord-263645-wupre5uj	213	11	natural	natural	JJ
cord-263645-wupre5uj	213	12	product	product	NN
cord-263645-wupre5uj	213	13	-	-	HYPH
cord-263645-wupre5uj	213	14	based	base	VBN
cord-263645-wupre5uj	213	15	screening	screening	NN
cord-263645-wupre5uj	213	16	to	to	TO
cord-263645-wupre5uj	213	17	access	access	VB
cord-263645-wupre5uj	213	18	vast	vast	JJ
cord-263645-wupre5uj	213	19	chemical	chemical	JJ
cord-263645-wupre5uj	213	20	space	space	NN
cord-263645-wupre5uj	213	21	with	with	IN
cord-263645-wupre5uj	213	22	fewer	few	JJR
cord-263645-wupre5uj	213	23	ligands	ligand	NNS
cord-263645-wupre5uj	213	24	(	(	-LRB-
cord-263645-wupre5uj	213	25	41	41	CD
cord-263645-wupre5uj	213	26	)	)	-RRB-
cord-263645-wupre5uj	213	27	and	and	CC
cord-263645-wupre5uj	213	28	to	to	TO
cord-263645-wupre5uj	213	29	probe	probe	VB
cord-263645-wupre5uj	213	30	known	know	VBN
cord-263645-wupre5uj	213	31	biologically	biologically	RB
cord-263645-wupre5uj	213	32	relevant	relevant	JJ
cord-263645-wupre5uj	213	33	chemical	chemical	NN
cord-263645-wupre5uj	213	34	space	space	NN
cord-263645-wupre5uj	213	35	,	,	,
cord-263645-wupre5uj	213	36	respectively	respectively	RB
cord-263645-wupre5uj	213	37	(	(	-LRB-
cord-263645-wupre5uj	213	38	101	101	CD
cord-263645-wupre5uj	213	39	)	)	-RRB-
cord-263645-wupre5uj	213	40	.	.	.
cord-263645-wupre5uj	214	1	Additional	additional	JJ
cord-263645-wupre5uj	214	2	high	high	JJ
cord-263645-wupre5uj	214	3	-	-	HYPH
cord-263645-wupre5uj	214	4	throughput	throughput	NN
cord-263645-wupre5uj	214	5	screens	screen	NNS
cord-263645-wupre5uj	214	6	could	could	MD
cord-263645-wupre5uj	214	7	likewise	likewise	RB
cord-263645-wupre5uj	214	8	discover	discover	VB
cord-263645-wupre5uj	214	9	novel	novel	NN
cord-263645-wupre5uj	214	10	chemotypes	chemotype	NNS
cord-263645-wupre5uj	214	11	,	,	,
cord-263645-wupre5uj	214	12	though	though	IN
cord-263645-wupre5uj	214	13	the	the	DT
cord-263645-wupre5uj	214	14	expense	expense	NN
cord-263645-wupre5uj	214	15	may	may	MD
cord-263645-wupre5uj	214	16	exceed	exceed	VB
cord-263645-wupre5uj	214	17	the	the	DT
cord-263645-wupre5uj	214	18	resources	resource	NNS
cord-263645-wupre5uj	214	19	available	available	JJ
cord-263645-wupre5uj	214	20	in	in	IN
cord-263645-wupre5uj	214	21	academia	academia	NN
cord-263645-wupre5uj	214	22	,	,	,
cord-263645-wupre5uj	214	23	where	where	WRB
cord-263645-wupre5uj	214	24	focused	focus	VBN
cord-263645-wupre5uj	214	25	approaches	approach	NNS
cord-263645-wupre5uj	214	26	are	be	VBP
cord-263645-wupre5uj	214	27	more	more	RBR
cord-263645-wupre5uj	214	28	attainable	attainable	JJ
cord-263645-wupre5uj	214	29	.	.	.
cord-263645-wupre5uj	215	1	Continued	continued	JJ
cord-263645-wupre5uj	215	2	progress	progress	NN
cord-263645-wupre5uj	215	3	in	in	IN
cord-263645-wupre5uj	215	4	the	the	DT
cord-263645-wupre5uj	215	5	development	development	NN
cord-263645-wupre5uj	215	6	and	and	CC
cord-263645-wupre5uj	215	7	refinement	refinement	NN
cord-263645-wupre5uj	215	8	of	of	IN
cord-263645-wupre5uj	215	9	computational	computational	JJ
cord-263645-wupre5uj	215	10	tools	tool	NNS
cord-263645-wupre5uj	215	11	will	will	MD
cord-263645-wupre5uj	215	12	also	also	RB
cord-263645-wupre5uj	215	13	aid	aid	VB
cord-263645-wupre5uj	215	14	in	in	IN
cord-263645-wupre5uj	215	15	expanding	expand	VBG
cord-263645-wupre5uj	215	16	the	the	DT
cord-263645-wupre5uj	215	17	boundaries	boundary	NNS
cord-263645-wupre5uj	215	18	of	of	IN
cord-263645-wupre5uj	215	19	focused	focused	JJ
cord-263645-wupre5uj	215	20	screening	screening	NN
cord-263645-wupre5uj	215	21	and	and	CC
cord-263645-wupre5uj	215	22	structurebased	structurebased	JJ
cord-263645-wupre5uj	215	23	design	design	NN
cord-263645-wupre5uj	215	24	;	;	:
cord-263645-wupre5uj	215	25	(	(	-LRB-
cord-263645-wupre5uj	215	26	56	56	CD
cord-263645-wupre5uj	215	27	,	,	,
cord-263645-wupre5uj	215	28	57	57	CD
cord-263645-wupre5uj	215	29	)	)	-RRB-
cord-263645-wupre5uj	216	1	although	although	IN
cord-263645-wupre5uj	216	2	the	the	DT
cord-263645-wupre5uj	216	3	latter	latter	JJ
cord-263645-wupre5uj	216	4	will	will	MD
cord-263645-wupre5uj	216	5	also	also	RB
cord-263645-wupre5uj	216	6	depend	depend	VB
cord-263645-wupre5uj	216	7	upon	upon	IN
cord-263645-wupre5uj	216	8	advancements	advancement	NNS
cord-263645-wupre5uj	216	9	for	for	IN
cord-263645-wupre5uj	216	10	accurately	accurately	RB
cord-263645-wupre5uj	216	11	determining	determine	VBG
cord-263645-wupre5uj	216	12	atomic	atomic	JJ
cord-263645-wupre5uj	216	13	resolution	resolution	NN
cord-263645-wupre5uj	216	14	structures	structure	NNS
cord-263645-wupre5uj	216	15	(	(	-LRB-
cord-263645-wupre5uj	216	16	8	8	CD
cord-263645-wupre5uj	216	17	,	,	,
cord-263645-wupre5uj	216	18	9	9	CD
cord-263645-wupre5uj	216	19	,	,	,
cord-263645-wupre5uj	216	20	37	37	CD
cord-263645-wupre5uj	216	21	,	,	,
cord-263645-wupre5uj	216	22	38	38	CD
cord-263645-wupre5uj	216	23	)	)	-RRB-
cord-263645-wupre5uj	216	24	.	.	.
cord-263645-wupre5uj	217	1	In	in	IN
cord-263645-wupre5uj	217	2	addition	addition	NN
cord-263645-wupre5uj	217	3	,	,	,
cord-263645-wupre5uj	217	4	in	in	IN
cord-263645-wupre5uj	217	5	vitro	vitro	FW
cord-263645-wupre5uj	217	6	or	or	CC
cord-263645-wupre5uj	217	7	cellular	cellular	JJ
cord-263645-wupre5uj	217	8	activity	activity	NN
cord-263645-wupre5uj	217	9	-	-	HYPH
cord-263645-wupre5uj	217	10	based	base	VBN
cord-263645-wupre5uj	217	11	assays	assay	NNS
cord-263645-wupre5uj	217	12	that	that	WDT
cord-263645-wupre5uj	217	13	probe	probe	VBP
cord-263645-wupre5uj	217	14	well	well	RB
cord-263645-wupre5uj	217	15	-	-	HYPH
cord-263645-wupre5uj	217	16	studied	study	VBN
cord-263645-wupre5uj	217	17	RNA	RNA	NNP
cord-263645-wupre5uj	217	18	functions	function	NNS
cord-263645-wupre5uj	217	19	(	(	-LRB-
cord-263645-wupre5uj	217	20	e.g.	e.g.	RB
cord-263645-wupre5uj	217	21	splicing	splicing	NN
cord-263645-wupre5uj	217	22	,	,	,
cord-263645-wupre5uj	217	23	translation	translation	NN
cord-263645-wupre5uj	217	24	,	,	,
cord-263645-wupre5uj	217	25	or	or	CC
cord-263645-wupre5uj	217	26	processing	processing	NN
cord-263645-wupre5uj	217	27	)	)	-RRB-
cord-263645-wupre5uj	217	28	may	may	MD
cord-263645-wupre5uj	217	29	be	be	VB
cord-263645-wupre5uj	217	30	more	more	RBR
cord-263645-wupre5uj	217	31	practical	practical	JJ
cord-263645-wupre5uj	217	32	starting	starting	NN
cord-263645-wupre5uj	217	33	points	point	NNS
cord-263645-wupre5uj	217	34	to	to	TO
cord-263645-wupre5uj	217	35	identify	identify	VB
cord-263645-wupre5uj	217	36	chemical	chemical	JJ
cord-263645-wupre5uj	217	37	probes	probe	NNS
cord-263645-wupre5uj	217	38	.	.	.
cord-263645-wupre5uj	218	1	This	this	DT
cord-263645-wupre5uj	218	2	includes	include	VBZ
cord-263645-wupre5uj	218	3	screening	screening	NN
cord-263645-wupre5uj	218	4	strategies	strategy	NNS
cord-263645-wupre5uj	218	5	described	describe	VBN
cord-263645-wupre5uj	218	6	herein	herein	RB
cord-263645-wupre5uj	218	7	as	as	RB
cord-263645-wupre5uj	218	8	well	well	RB
cord-263645-wupre5uj	218	9	as	as	IN
cord-263645-wupre5uj	218	10	others	other	NNS
cord-263645-wupre5uj	218	11	recently	recently	RB
cord-263645-wupre5uj	218	12	developed	develop	VBD
cord-263645-wupre5uj	218	13	(	(	-LRB-
cord-263645-wupre5uj	218	14	102	102	CD
cord-263645-wupre5uj	218	15	,	,	,
cord-263645-wupre5uj	218	16	103	103	CD
cord-263645-wupre5uj	218	17	)	)	-RRB-
cord-263645-wupre5uj	218	18	.	.	.
cord-263645-wupre5uj	219	1	Finally	finally	RB
cord-263645-wupre5uj	219	2	,	,	,
cord-263645-wupre5uj	219	3	numerous	numerous	JJ
cord-263645-wupre5uj	219	4	opportunities	opportunity	NNS
cord-263645-wupre5uj	219	5	exist	exist	VBP
cord-263645-wupre5uj	219	6	to	to	TO
cord-263645-wupre5uj	219	7	build	build	VB
cord-263645-wupre5uj	219	8	upon	upon	IN
cord-263645-wupre5uj	219	9	the	the	DT
cord-263645-wupre5uj	219	10	established	establish	VBN
cord-263645-wupre5uj	219	11	multivalent	multivalent	JJ
cord-263645-wupre5uj	219	12	targeting	targeting	NN
cord-263645-wupre5uj	219	13	strategies	strategy	NNS
cord-263645-wupre5uj	219	14	discussed	discuss	VBN
cord-263645-wupre5uj	219	15	above	above	RB
cord-263645-wupre5uj	219	16	,	,	,
cord-263645-wupre5uj	219	17	particularly	particularly	RB
cord-263645-wupre5uj	219	18	the	the	DT
cord-263645-wupre5uj	219	19	application	application	NN
cord-263645-wupre5uj	219	20	of	of	IN
cord-263645-wupre5uj	219	21	dynamic	dynamic	JJ
cord-263645-wupre5uj	219	22	combinatorial	combinatorial	JJ
cord-263645-wupre5uj	219	23	chemistry	chemistry	NN
cord-263645-wupre5uj	219	24	to	to	IN
cord-263645-wupre5uj	219	25	RNAs	rna	NNS
cord-263645-wupre5uj	219	26	of	of	IN
cord-263645-wupre5uj	219	27	unknown	unknown	JJ
cord-263645-wupre5uj	219	28	structure	structure	NN
cord-263645-wupre5uj	219	29	.	.	.
cord-263645-wupre5uj	220	1	When	when	WRB
cord-263645-wupre5uj	220	2	using	use	VBG
cord-263645-wupre5uj	220	3	a	a	DT
cord-263645-wupre5uj	220	4	chemical	chemical	JJ
cord-263645-wupre5uj	220	5	probe	probe	NN
cord-263645-wupre5uj	220	6	in	in	IN
cord-263645-wupre5uj	220	7	a	a	DT
cord-263645-wupre5uj	220	8	biological	biological	JJ
cord-263645-wupre5uj	220	9	system	system	NN
cord-263645-wupre5uj	220	10	,	,	,
cord-263645-wupre5uj	220	11	the	the	DT
cord-263645-wupre5uj	220	12	quality	quality	NN
cord-263645-wupre5uj	220	13	and	and	CC
cord-263645-wupre5uj	220	14	specificity	specificity	NN
cord-263645-wupre5uj	220	15	of	of	IN
cord-263645-wupre5uj	220	16	the	the	DT
cord-263645-wupre5uj	220	17	probe	probe	NN
cord-263645-wupre5uj	220	18	must	must	MD
cord-263645-wupre5uj	220	19	be	be	VB
cord-263645-wupre5uj	220	20	well	well	RB
cord-263645-wupre5uj	220	21	characterized	characterize	VBN
cord-263645-wupre5uj	220	22	to	to	TO
cord-263645-wupre5uj	220	23	draw	draw	VB
cord-263645-wupre5uj	220	24	accurate	accurate	JJ
cord-263645-wupre5uj	220	25	and	and	CC
cord-263645-wupre5uj	220	26	meaningful	meaningful	JJ
cord-263645-wupre5uj	220	27	conclusions	conclusion	NNS
cord-263645-wupre5uj	220	28	,	,	,
cord-263645-wupre5uj	220	29	as	as	IN
cord-263645-wupre5uj	220	30	recently	recently	RB
cord-263645-wupre5uj	220	31	highlighted	highlight	VBN
cord-263645-wupre5uj	220	32	by	by	IN
cord-263645-wupre5uj	220	33	several	several	JJ
cord-263645-wupre5uj	220	34	preeminent	preeminent	JJ
cord-263645-wupre5uj	220	35	chemical	chemical	NN
cord-263645-wupre5uj	220	36	biologists	biologist	NNS
cord-263645-wupre5uj	220	37	(	(	-LRB-
cord-263645-wupre5uj	220	38	11	11	CD
cord-263645-wupre5uj	220	39	,	,	,
cord-263645-wupre5uj	220	40	12	12	CD
cord-263645-wupre5uj	220	41	,	,	,
cord-263645-wupre5uj	220	42	74	74	CD
cord-263645-wupre5uj	220	43	,	,	,
cord-263645-wupre5uj	220	44	75	75	CD
cord-263645-wupre5uj	220	45	)	)	-RRB-
cord-263645-wupre5uj	220	46	.	.	.
cord-263645-wupre5uj	221	1	Evaluation	evaluation	NN
cord-263645-wupre5uj	221	2	of	of	IN
cord-263645-wupre5uj	221	3	the	the	DT
cord-263645-wupre5uj	221	4	chemical	chemical	NN
cord-263645-wupre5uj	221	5	probes	probe	NNS
cord-263645-wupre5uj	221	6	revealed	reveal	VBD
cord-263645-wupre5uj	221	7	a	a	DT
cord-263645-wupre5uj	221	8	diverse	diverse	JJ
cord-263645-wupre5uj	221	9	spectrum	spectrum	NN
cord-263645-wupre5uj	221	10	of	of	IN
cord-263645-wupre5uj	221	11	characterization	characterization	NN
cord-263645-wupre5uj	221	12	techniques	technique	NNS
cord-263645-wupre5uj	221	13	with	with	IN
cord-263645-wupre5uj	221	14	few	few	JJ
cord-263645-wupre5uj	221	15	ligands	ligand	NNS
cord-263645-wupre5uj	221	16	meeting	meet	VBG
cord-263645-wupre5uj	221	17	the	the	DT
cord-263645-wupre5uj	221	18	traditional	traditional	JJ
cord-263645-wupre5uj	221	19	criteria	criterion	NNS
cord-263645-wupre5uj	221	20	for	for	IN
cord-263645-wupre5uj	221	21	robust	robust	JJ
cord-263645-wupre5uj	221	22	chemical	chemical	JJ
cord-263645-wupre5uj	221	23	probes	probe	NNS
cord-263645-wupre5uj	221	24	,	,	,
cord-263645-wupre5uj	221	25	and	and	CC
cord-263645-wupre5uj	221	26	not	not	RB
cord-263645-wupre5uj	221	27	all	all	DT
cord-263645-wupre5uj	221	28	of	of	IN
cord-263645-wupre5uj	221	29	these	these	DT
cord-263645-wupre5uj	221	30	gaps	gap	NNS
cord-263645-wupre5uj	221	31	can	can	MD
cord-263645-wupre5uj	221	32	be	be	VB
cord-263645-wupre5uj	221	33	attributed	attribute	VBN
cord-263645-wupre5uj	221	34	to	to	IN
cord-263645-wupre5uj	221	35	a	a	DT
cord-263645-wupre5uj	221	36	lack	lack	NN
cord-263645-wupre5uj	221	37	of	of	IN
cord-263645-wupre5uj	221	38	relevant	relevant	JJ
cord-263645-wupre5uj	221	39	tools	tool	NNS
cord-263645-wupre5uj	221	40	.	.	.
cord-263645-wupre5uj	222	1	For	for	IN
cord-263645-wupre5uj	222	2	example	example	NN
cord-263645-wupre5uj	222	3	,	,	,
cord-263645-wupre5uj	222	4	characterization	characterization	NN
cord-263645-wupre5uj	222	5	inconsistencies	inconsistency	NNS
cord-263645-wupre5uj	222	6	include	include	VBP
cord-263645-wupre5uj	222	7	incomplete	incomplete	JJ
cord-263645-wupre5uj	222	8	reports	report	NNS
cord-263645-wupre5uj	222	9	of	of	IN
cord-263645-wupre5uj	222	10	cytotoxicity	cytotoxicity	NN
cord-263645-wupre5uj	222	11	and	and	CC
cord-263645-wupre5uj	222	12	a	a	DT
cord-263645-wupre5uj	222	13	lack	lack	NN
cord-263645-wupre5uj	222	14	of	of	IN
cord-263645-wupre5uj	222	15	attention	attention	NN
cord-263645-wupre5uj	222	16	to	to	IN
cord-263645-wupre5uj	222	17	cell	cell	NN
cord-263645-wupre5uj	222	18	permeability	permeability	NN
cord-263645-wupre5uj	222	19	and	and	CC
cord-263645-wupre5uj	222	20	localization	localization	NN
cord-263645-wupre5uj	222	21	.	.	.
cord-263645-wupre5uj	223	1	In	in	IN
cord-263645-wupre5uj	223	2	addition	addition	NN
cord-263645-wupre5uj	223	3	,	,	,
cord-263645-wupre5uj	223	4	many	many	JJ
cord-263645-wupre5uj	223	5	in	in	IN
cord-263645-wupre5uj	223	6	vitro	vitro	FW
cord-263645-wupre5uj	223	7	assays	assay	NNS
cord-263645-wupre5uj	223	8	are	be	VBP
cord-263645-wupre5uj	223	9	accessible	accessible	JJ
cord-263645-wupre5uj	223	10	to	to	TO
cord-263645-wupre5uj	223	11	help	help	VB
cord-263645-wupre5uj	223	12	establish	establish	VB
cord-263645-wupre5uj	223	13	the	the	DT
cord-263645-wupre5uj	223	14	potency	potency	NN
cord-263645-wupre5uj	223	15	and	and	CC
cord-263645-wupre5uj	223	16	selectivity	selectivity	NN
cord-263645-wupre5uj	223	17	of	of	IN
cord-263645-wupre5uj	223	18	a	a	DT
cord-263645-wupre5uj	223	19	probe	probe	NN
cord-263645-wupre5uj	223	20	in	in	IN
cord-263645-wupre5uj	223	21	multiple	multiple	JJ
cord-263645-wupre5uj	223	22	experiments	experiment	NNS
cord-263645-wupre5uj	223	23	,	,	,
cord-263645-wupre5uj	223	24	and	and	CC
cord-263645-wupre5uj	223	25	these	these	DT
cord-263645-wupre5uj	223	26	assays	assay	NNS
cord-263645-wupre5uj	223	27	should	should	MD
cord-263645-wupre5uj	223	28	include	include	VB
cord-263645-wupre5uj	223	29	evaluation	evaluation	NN
cord-263645-wupre5uj	223	30	against	against	IN
cord-263645-wupre5uj	223	31	both	both	DT
cord-263645-wupre5uj	223	32	specifically	specifically	RB
cord-263645-wupre5uj	223	33	mutated	mutate	VBN
cord-263645-wupre5uj	223	34	targets	target	NNS
cord-263645-wupre5uj	223	35	and	and	CC
cord-263645-wupre5uj	223	36	a	a	DT
cord-263645-wupre5uj	223	37	number	number	NN
cord-263645-wupre5uj	223	38	of	of	IN
cord-263645-wupre5uj	223	39	other	other	JJ
cord-263645-wupre5uj	223	40	structured	structured	JJ
cord-263645-wupre5uj	223	41	RNAs	rna	NNS
cord-263645-wupre5uj	223	42	.	.	.
cord-263645-wupre5uj	224	1	Any	any	DT
cord-263645-wupre5uj	224	2	cell	cell	NN
cord-263645-wupre5uj	224	3	-	-	HYPH
cord-263645-wupre5uj	224	4	based	base	VBN
cord-263645-wupre5uj	224	5	observations	observation	NNS
cord-263645-wupre5uj	224	6	should	should	MD
cord-263645-wupre5uj	224	7	be	be	VB
cord-263645-wupre5uj	224	8	reproducible	reproducible	JJ
cord-263645-wupre5uj	224	9	in	in	IN
cord-263645-wupre5uj	224	10	multiple	multiple	JJ
cord-263645-wupre5uj	224	11	cell	cell	NN
cord-263645-wupre5uj	224	12	lines	line	NNS
cord-263645-wupre5uj	224	13	and	and	CC
cord-263645-wupre5uj	224	14	validated	validate	VBD
cord-263645-wupre5uj	224	15	in	in	IN
cord-263645-wupre5uj	224	16	the	the	DT
cord-263645-wupre5uj	224	17	absence	absence	NN
cord-263645-wupre5uj	224	18	of	of	IN
cord-263645-wupre5uj	224	19	the	the	DT
cord-263645-wupre5uj	224	20	target	target	NN
cord-263645-wupre5uj	224	21	by	by	IN
cord-263645-wupre5uj	224	22	utilizing	utilize	VBG
cord-263645-wupre5uj	224	23	siRNA	siRNA	NNP
cord-263645-wupre5uj	224	24	or	or	CC
cord-263645-wupre5uj	224	25	CRISPR	CRISPR	NNP
cord-263645-wupre5uj	224	26	-	-	HYPH
cord-263645-wupre5uj	224	27	Cas	Cas	NNP
cord-263645-wupre5uj	224	28	technologies	technology	NNS
cord-263645-wupre5uj	224	29	.	.	.
cord-263645-wupre5uj	225	1	Further	further	RB
cord-263645-wupre5uj	225	2	,	,	,
cord-263645-wupre5uj	225	3	on	on	IN
cord-263645-wupre5uj	225	4	-	-	HYPH
cord-263645-wupre5uj	225	5	target	target	NN
cord-263645-wupre5uj	225	6	effects	effect	NNS
cord-263645-wupre5uj	225	7	should	should	MD
cord-263645-wupre5uj	225	8	be	be	VB
cord-263645-wupre5uj	225	9	established	establish	VBN
cord-263645-wupre5uj	225	10	by	by	IN
cord-263645-wupre5uj	225	11	using	use	VBG
cord-263645-wupre5uj	225	12	a	a	DT
cord-263645-wupre5uj	225	13	number	number	NN
cord-263645-wupre5uj	225	14	of	of	IN
cord-263645-wupre5uj	225	15	spatial	spatial	JJ
cord-263645-wupre5uj	225	16	-	-	HYPH
cord-263645-wupre5uj	225	17	based	base	VBN
cord-263645-wupre5uj	225	18	experiments	experiment	NNS
cord-263645-wupre5uj	225	19	(	(	-LRB-
cord-263645-wupre5uj	225	20	12	12	CD
cord-263645-wupre5uj	225	21	)	)	-RRB-
cord-263645-wupre5uj	225	22	.	.	.
cord-263645-wupre5uj	226	1	These	these	DT
cord-263645-wupre5uj	226	2	include	include	VBP
cord-263645-wupre5uj	226	3	the	the	DT
cord-263645-wupre5uj	226	4	biochemical	biochemical	JJ
cord-263645-wupre5uj	226	5	methods	method	NNS
cord-263645-wupre5uj	226	6	described	describe	VBN
cord-263645-wupre5uj	226	7	herein	herein	RB
cord-263645-wupre5uj	226	8	(	(	-LRB-
cord-263645-wupre5uj	226	9	e.g.	e.g.	DT
cord-263645-wupre5uj	226	10	Chem	Chem	NNP
cord-263645-wupre5uj	226	11	-	-	HYPH
cord-263645-wupre5uj	226	12	CLIP	CLIP	NNP
cord-263645-wupre5uj	226	13	or	or	CC
cord-263645-wupre5uj	226	14	RIP	rip	NN
cord-263645-wupre5uj	226	15	)	)	-RRB-
cord-263645-wupre5uj	226	16	and	and	CC
cord-263645-wupre5uj	226	17	novel	novel	JJ
cord-263645-wupre5uj	226	18	applications	application	NNS
cord-263645-wupre5uj	226	19	of	of	IN
cord-263645-wupre5uj	226	20	other	other	JJ
cord-263645-wupre5uj	226	21	technologies	technology	NNS
cord-263645-wupre5uj	226	22	such	such	JJ
cord-263645-wupre5uj	226	23	as	as	IN
cord-263645-wupre5uj	226	24	in	in	IN
cord-263645-wupre5uj	226	25	-	-	HYPH
cord-263645-wupre5uj	226	26	cell	cell	NN
cord-263645-wupre5uj	226	27	chemical	chemical	NN
cord-263645-wupre5uj	226	28	probing	probing	NN
cord-263645-wupre5uj	226	29	(	(	-LRB-
cord-263645-wupre5uj	226	30	104	104	CD
cord-263645-wupre5uj	226	31	,	,	,
cord-263645-wupre5uj	226	32	105	105	CD
cord-263645-wupre5uj	226	33	)	)	-RRB-
cord-263645-wupre5uj	226	34	to	to	TO
cord-263645-wupre5uj	226	35	observe	observe	VB
cord-263645-wupre5uj	226	36	changes	change	NNS
cord-263645-wupre5uj	226	37	in	in	IN
cord-263645-wupre5uj	226	38	RNA	RNA	NNP
cord-263645-wupre5uj	226	39	secondary	secondary	JJ
cord-263645-wupre5uj	226	40	structure	structure	NN
cord-263645-wupre5uj	226	41	upon	upon	IN
cord-263645-wupre5uj	226	42	ligand	ligand	NN
cord-263645-wupre5uj	226	43	binding	binding	NN
cord-263645-wupre5uj	226	44	or	or	CC
cord-263645-wupre5uj	226	45	photoaffinity	photoaffinity	NN
cord-263645-wupre5uj	226	46	labeling	labeling	NN
cord-263645-wupre5uj	226	47	(	(	-LRB-
cord-263645-wupre5uj	226	48	106	106	CD
cord-263645-wupre5uj	226	49	)	)	-RRB-
cord-263645-wupre5uj	226	50	to	to	TO
cord-263645-wupre5uj	226	51	assess	assess	VB
cord-263645-wupre5uj	226	52	target	target	NN
cord-263645-wupre5uj	226	53	engagement	engagement	NN
cord-263645-wupre5uj	226	54	under	under	IN
cord-263645-wupre5uj	226	55	temporal	temporal	JJ
cord-263645-wupre5uj	226	56	control	control	NN
cord-263645-wupre5uj	226	57	.	.	.
cord-263645-wupre5uj	227	1	If	if	IN
cord-263645-wupre5uj	227	2	plausible	plausible	JJ
cord-263645-wupre5uj	227	3	,	,	,
cord-263645-wupre5uj	227	4	serial	serial	JJ
cord-263645-wupre5uj	227	5	passage	passage	NN
cord-263645-wupre5uj	227	6	experiments	experiment	NNS
cord-263645-wupre5uj	227	7	followed	follow	VBN
cord-263645-wupre5uj	227	8	by	by	IN
cord-263645-wupre5uj	227	9	deep	deep	JJ
cord-263645-wupre5uj	227	10	sequencing	sequencing	NN
cord-263645-wupre5uj	227	11	should	should	MD
cord-263645-wupre5uj	227	12	also	also	RB
cord-263645-wupre5uj	227	13	be	be	VB
cord-263645-wupre5uj	227	14	performed	perform	VBN
cord-263645-wupre5uj	227	15	,	,	,
cord-263645-wupre5uj	227	16	even	even	RB
cord-263645-wupre5uj	227	17	in	in	IN
cord-263645-wupre5uj	227	18	human	human	JJ
cord-263645-wupre5uj	227	19	systems	system	NNS
cord-263645-wupre5uj	227	20	(	(	-LRB-
cord-263645-wupre5uj	227	21	107	107	CD
cord-263645-wupre5uj	227	22	)	)	-RRB-
cord-263645-wupre5uj	227	23	,	,	,
cord-263645-wupre5uj	227	24	to	to	TO
cord-263645-wupre5uj	227	25	identify	identify	VB
cord-263645-wupre5uj	227	26	ligandescaping	ligandescape	VBG
cord-263645-wupre5uj	227	27	mutations	mutation	NNS
cord-263645-wupre5uj	227	28	to	to	TO
cord-263645-wupre5uj	227	29	confirm	confirm	VB
cord-263645-wupre5uj	227	30	target	target	NN
cord-263645-wupre5uj	227	31	engagement	engagement	NN
cord-263645-wupre5uj	227	32	and/or	and/or	CC
cord-263645-wupre5uj	227	33	off	off	IN
cord-263645-wupre5uj	227	34	-	-	HYPH
cord-263645-wupre5uj	227	35	target	target	NN
cord-263645-wupre5uj	227	36	effects	effect	NNS
cord-263645-wupre5uj	227	37	.	.	.
cord-263645-wupre5uj	228	1	Lastly	lastly	RB
cord-263645-wupre5uj	228	2	,	,	,
cord-263645-wupre5uj	228	3	it	-PRON-	PRP
cord-263645-wupre5uj	228	4	is	be	VBZ
cord-263645-wupre5uj	228	5	critical	critical	JJ
cord-263645-wupre5uj	228	6	to	to	TO
cord-263645-wupre5uj	228	7	use	use	VB
cord-263645-wupre5uj	228	8	an	an	DT
cord-263645-wupre5uj	228	9	inactive	inactive	JJ
cord-263645-wupre5uj	228	10	analog	analog	NN
cord-263645-wupre5uj	228	11	and	and	CC
cord-263645-wupre5uj	228	12	an	an	DT
cord-263645-wupre5uj	228	13	active	active	JJ
cord-263645-wupre5uj	228	14	analog	analog	NN
cord-263645-wupre5uj	228	15	from	from	IN
cord-263645-wupre5uj	228	16	a	a	DT
cord-263645-wupre5uj	228	17	different	different	JJ
cord-263645-wupre5uj	228	18	chemical	chemical	NN
cord-263645-wupre5uj	228	19	class	class	NN
cord-263645-wupre5uj	228	20	,	,	,
cord-263645-wupre5uj	228	21	if	if	IN
cord-263645-wupre5uj	228	22	feasible	feasible	JJ
cord-263645-wupre5uj	228	23	,	,	,
cord-263645-wupre5uj	228	24	to	to	TO
cord-263645-wupre5uj	228	25	draw	draw	VB
cord-263645-wupre5uj	228	26	conclusions	conclusion	NNS
cord-263645-wupre5uj	228	27	regarding	regard	VBG
cord-263645-wupre5uj	228	28	the	the	DT
cord-263645-wupre5uj	228	29	targeted	target	VBN
cord-263645-wupre5uj	228	30	biology	biology	NN
cord-263645-wupre5uj	228	31	.	.	.
cord-263645-wupre5uj	229	1	Moving	move	VBG
cord-263645-wupre5uj	229	2	toward	toward	IN
cord-263645-wupre5uj	229	3	these	these	DT
cord-263645-wupre5uj	229	4	standards	standard	NNS
cord-263645-wupre5uj	229	5	will	will	MD
cord-263645-wupre5uj	229	6	be	be	VB
cord-263645-wupre5uj	229	7	crucial	crucial	JJ
cord-263645-wupre5uj	229	8	for	for	IN
cord-263645-wupre5uj	229	9	the	the	DT
cord-263645-wupre5uj	229	10	RNA	RNA	NNP
cord-263645-wupre5uj	229	11	-	-	HYPH
cord-263645-wupre5uj	229	12	targeting	target	VBG
cord-263645-wupre5uj	229	13	field	field	NN
cord-263645-wupre5uj	229	14	to	to	TO
cord-263645-wupre5uj	229	15	avoid	avoid	VB
cord-263645-wupre5uj	229	16	the	the	DT
cord-263645-wupre5uj	229	17	scientific	scientific	JJ
cord-263645-wupre5uj	229	18	pollution	pollution	NN
cord-263645-wupre5uj	229	19	that	that	WDT
cord-263645-wupre5uj	229	20	has	have	VBZ
cord-263645-wupre5uj	229	21	plagued	plague	VBN
cord-263645-wupre5uj	229	22	many	many	JJ
cord-263645-wupre5uj	229	23	others	other	NNS
cord-263645-wupre5uj	229	24	(	(	-LRB-
cord-263645-wupre5uj	229	25	11	11	CD
cord-263645-wupre5uj	229	26	,	,	,
cord-263645-wupre5uj	229	27	12	12	CD
cord-263645-wupre5uj	229	28	,	,	,
cord-263645-wupre5uj	229	29	74	74	CD
cord-263645-wupre5uj	229	30	)	)	-RRB-
cord-263645-wupre5uj	229	31	.	.	.
cord-263645-wupre5uj	230	1	For	for	IN
cord-263645-wupre5uj	230	2	comparison	comparison	NN
cord-263645-wupre5uj	230	3	,	,	,
cord-263645-wupre5uj	230	4	we	-PRON-	PRP
cord-263645-wupre5uj	230	5	note	note	VBP
cord-263645-wupre5uj	230	6	that	that	IN
cord-263645-wupre5uj	230	7	over	over	IN
cord-263645-wupre5uj	230	8	a	a	DT
cord-263645-wupre5uj	230	9	decade	decade	NN
cord-263645-wupre5uj	230	10	ago	ago	IN
cord-263645-wupre5uj	230	11	chemical	chemical	NN
cord-263645-wupre5uj	230	12	probe	probe	NN
cord-263645-wupre5uj	230	13	discovery	discovery	NN
cord-263645-wupre5uj	230	14	for	for	IN
cord-263645-wupre5uj	230	15	another	another	DT
cord-263645-wupre5uj	230	16	'	'	``
cord-263645-wupre5uj	230	17	undruggable	undruggable	JJ
cord-263645-wupre5uj	230	18	'	'	''
cord-263645-wupre5uj	230	19	target	target	NN
cord-263645-wupre5uj	230	20	,	,	,
cord-263645-wupre5uj	230	21	protein	protein	NN
cord-263645-wupre5uj	230	22	:	:	:
cord-263645-wupre5uj	230	23	protein	protein	NN
cord-263645-wupre5uj	230	24	interactions	interaction	NNS
cord-263645-wupre5uj	230	25	,	,	,
cord-263645-wupre5uj	230	26	was	be	VBD
cord-263645-wupre5uj	230	27	in	in	IN
cord-263645-wupre5uj	230	28	its	-PRON-	PRP$
cord-263645-wupre5uj	230	29	infancy	infancy	NN
cord-263645-wupre5uj	230	30	with	with	IN
cord-263645-wupre5uj	230	31	only	only	RB
cord-263645-wupre5uj	230	32	19	19	CD
cord-263645-wupre5uj	230	33	known	know	VBN
cord-263645-wupre5uj	230	34	small	small	JJ
cord-263645-wupre5uj	230	35	molecule	molecule	NN
cord-263645-wupre5uj	230	36	inhibitors	inhibitor	NNS
cord-263645-wupre5uj	230	37	(	(	-LRB-
cord-263645-wupre5uj	230	38	108	108	CD
cord-263645-wupre5uj	230	39	)	)	-RRB-
cord-263645-wupre5uj	230	40	.	.	.
cord-263645-wupre5uj	231	1	However	however	RB
cord-263645-wupre5uj	231	2	,	,	,
cord-263645-wupre5uj	231	3	novel	novel	JJ
cord-263645-wupre5uj	231	4	advances	advance	NNS
cord-263645-wupre5uj	231	5	in	in	IN
cord-263645-wupre5uj	231	6	screening	screening	NN
cord-263645-wupre5uj	231	7	approaches	approach	NNS
cord-263645-wupre5uj	231	8	and	and	CC
cord-263645-wupre5uj	231	9	design	design	NN
cord-263645-wupre5uj	231	10	strategies	strategy	NNS
cord-263645-wupre5uj	231	11	led	lead	VBD
cord-263645-wupre5uj	231	12	to	to	IN
cord-263645-wupre5uj	231	13	the	the	DT
cord-263645-wupre5uj	231	14	rapid	rapid	JJ
cord-263645-wupre5uj	231	15	discovery	discovery	NN
cord-263645-wupre5uj	231	16	of	of	IN
cord-263645-wupre5uj	231	17	thousands	thousand	NNS
cord-263645-wupre5uj	231	18	of	of	IN
cord-263645-wupre5uj	231	19	protein	protein	NN
cord-263645-wupre5uj	231	20	:	:	:
cord-263645-wupre5uj	231	21	protein	protein	NN
cord-263645-wupre5uj	231	22	interaction	interaction	NN
cord-263645-wupre5uj	231	23	inhibitors	inhibitor	NNS
cord-263645-wupre5uj	231	24	with	with	IN
cord-263645-wupre5uj	231	25	several	several	JJ
cord-263645-wupre5uj	231	26	entering	enter	VBG
cord-263645-wupre5uj	231	27	the	the	DT
cord-263645-wupre5uj	231	28	clinic	clinic	NN
cord-263645-wupre5uj	231	29	and	and	CC
cord-263645-wupre5uj	231	30	most	most	RBS
cord-263645-wupre5uj	231	31	also	also	RB
cord-263645-wupre5uj	231	32	breaking	break	VBG
cord-263645-wupre5uj	231	33	the	the	DT
cord-263645-wupre5uj	231	34	rules	rule	NNS
cord-263645-wupre5uj	231	35	of	of	IN
cord-263645-wupre5uj	231	36	'	'	``
cord-263645-wupre5uj	231	37	drug	drug	NN
cord-263645-wupre5uj	231	38	-	-	HYPH
cord-263645-wupre5uj	231	39	like	like	JJ
cord-263645-wupre5uj	231	40	chemical	chemical	JJ
cord-263645-wupre5uj	231	41	space	space	NN
cord-263645-wupre5uj	231	42	'	'	''
cord-263645-wupre5uj	231	43	(	(	-LRB-
cord-263645-wupre5uj	231	44	109	109	CD
cord-263645-wupre5uj	231	45	)	)	-RRB-
cord-263645-wupre5uj	231	46	.	.	.
cord-263645-wupre5uj	232	1	In	in	IN
cord-263645-wupre5uj	232	2	the	the	DT
cord-263645-wupre5uj	232	3	next	next	JJ
cord-263645-wupre5uj	232	4	five	five	CD
cord-263645-wupre5uj	232	5	years	year	NNS
cord-263645-wupre5uj	232	6	,	,	,
cord-263645-wupre5uj	232	7	we	-PRON-	PRP
cord-263645-wupre5uj	232	8	anticipate	anticipate	VBP
cord-263645-wupre5uj	232	9	that	that	IN
cord-263645-wupre5uj	232	10	the	the	DT
cord-263645-wupre5uj	232	11	innovations	innovation	NNS
cord-263645-wupre5uj	232	12	described	describe	VBN
cord-263645-wupre5uj	232	13	herein	herein	RB
cord-263645-wupre5uj	232	14	and	and	CC
cord-263645-wupre5uj	232	15	the	the	DT
cord-263645-wupre5uj	232	16	ones	one	NNS
cord-263645-wupre5uj	232	17	yet	yet	RB
cord-263645-wupre5uj	232	18	to	to	TO
cord-263645-wupre5uj	232	19	be	be	VB
cord-263645-wupre5uj	232	20	discovered	discover	VBN
cord-263645-wupre5uj	232	21	will	will	MD
cord-263645-wupre5uj	232	22	lead	lead	VB
cord-263645-wupre5uj	232	23	to	to	IN
cord-263645-wupre5uj	232	24	a	a	DT
cord-263645-wupre5uj	232	25	similar	similar	JJ
cord-263645-wupre5uj	232	26	surge	surge	NN
cord-263645-wupre5uj	232	27	in	in	IN
cord-263645-wupre5uj	232	28	reports	report	NNS
cord-263645-wupre5uj	232	29	of	of	IN
cord-263645-wupre5uj	232	30	RNA	RNA	NNP
cord-263645-wupre5uj	232	31	-	-	HYPH
cord-263645-wupre5uj	232	32	based	base	VBN
cord-263645-wupre5uj	232	33	chemical	chemical	NN
cord-263645-wupre5uj	232	34	probes	probe	NNS
cord-263645-wupre5uj	232	35	and	and	CC
cord-263645-wupre5uj	232	36	therapeutics	therapeutic	NNS
cord-263645-wupre5uj	232	37	.	.	.
cord-263645-wupre5uj	233	1	We	-PRON-	PRP
cord-263645-wupre5uj	233	2	also	also	RB
cord-263645-wupre5uj	233	3	expect	expect	VBP
cord-263645-wupre5uj	233	4	that	that	DT
cord-263645-wupre5uj	233	5	novel	novel	NN
cord-263645-wupre5uj	233	6	and	and	CC
cord-263645-wupre5uj	233	7	well	well	RB
cord-263645-wupre5uj	233	8	-	-	HYPH
cord-263645-wupre5uj	233	9	characterized	characterize	VBN
cord-263645-wupre5uj	233	10	chemical	chemical	NN
cord-263645-wupre5uj	233	11	probes	probe	NNS
cord-263645-wupre5uj	233	12	will	will	MD
cord-263645-wupre5uj	233	13	allow	allow	VB
cord-263645-wupre5uj	233	14	RNA	RNA	NNP
cord-263645-wupre5uj	233	15	biologists	biologist	NNS
cord-263645-wupre5uj	233	16	to	to	TO
cord-263645-wupre5uj	233	17	uncover	uncover	VB
cord-263645-wupre5uj	233	18	many	many	JJ
cord-263645-wupre5uj	233	19	more	more	RBR
cord-263645-wupre5uj	233	20	exciting	exciting	JJ
cord-263645-wupre5uj	233	21	and	and	CC
cord-263645-wupre5uj	233	22	unanticipated	unanticipated	JJ
cord-263645-wupre5uj	233	23	roles	role	NNS
cord-263645-wupre5uj	233	24	for	for	IN
cord-263645-wupre5uj	233	25	RNA	RNA	NNP
cord-263645-wupre5uj	233	26	,	,	,
cord-263645-wupre5uj	233	27	propelling	propel	VBG
cord-263645-wupre5uj	233	28	us	-PRON-	PRP
cord-263645-wupre5uj	233	29	into	into	IN
cord-263645-wupre5uj	233	30	the	the	DT
cord-263645-wupre5uj	233	31	next	next	JJ
cord-263645-wupre5uj	233	32	phase	phase	NN
cord-263645-wupre5uj	233	33	of	of	IN
cord-263645-wupre5uj	233	34	the	the	DT
cord-263645-wupre5uj	233	35	RNA	RNA	NNP
cord-263645-wupre5uj	233	36	revolution	revolution	NN
cord-263645-wupre5uj	233	37	.	.	.
cord-263645-wupre5uj	234	1	Supplementary	Supplementary	NNP
cord-263645-wupre5uj	234	2	Data	Data	NNP
cord-263645-wupre5uj	234	3	are	be	VBP
cord-263645-wupre5uj	234	4	available	available	JJ
cord-263645-wupre5uj	234	5	at	at	IN
cord-263645-wupre5uj	234	6	NAR	NAR	NNP
cord-263645-wupre5uj	234	7	Online	Online	NNP
cord-263645-wupre5uj	234	8	.	.	.
cord-263645-wupre5uj	235	1	The	the	DT
cord-263645-wupre5uj	235	2	noncoding	noncoding	JJ
cord-263645-wupre5uj	235	3	RNA	RNA	NNP
cord-263645-wupre5uj	235	4	revolution	revolution	NN
cord-263645-wupre5uj	235	5	-	-	HYPH
cord-263645-wupre5uj	235	6	trashing	trash	VBG
cord-263645-wupre5uj	235	7	old	old	JJ
cord-263645-wupre5uj	235	8	rules	rule	NNS
cord-263645-wupre5uj	235	9	to	to	TO
cord-263645-wupre5uj	235	10	forge	forge	VB
cord-263645-wupre5uj	235	11	new	new	JJ
cord-263645-wupre5uj	235	12	ones	one	NNS
cord-263645-wupre5uj	236	1	The	the	DT
cord-263645-wupre5uj	236	2	rise	rise	NN
cord-263645-wupre5uj	236	3	of	of	IN
cord-263645-wupre5uj	236	4	regulatory	regulatory	JJ
cord-263645-wupre5uj	236	5	RNA	RNA	NNP
cord-263645-wupre5uj	236	6	Viral	Viral	NNP
cord-263645-wupre5uj	236	7	noncoding	noncoding	JJ
cord-263645-wupre5uj	236	8	RNAs	rna	NNS
cord-263645-wupre5uj	236	9	:	:	:
cord-263645-wupre5uj	236	10	More	More	JJR
cord-263645-wupre5uj	236	11	surprises	surprise	NNS
cord-263645-wupre5uj	236	12	The	the	DT
cord-263645-wupre5uj	236	13	Encode	Encode	NNP
cord-263645-wupre5uj	236	14	Project	Project	NNP
cord-263645-wupre5uj	236	15	Consortium	Consortium	NNP
cord-263645-wupre5uj	236	16	(	(	-LRB-
cord-263645-wupre5uj	236	17	2007	2007	CD
cord-263645-wupre5uj	236	18	)	)	-RRB-
cord-263645-wupre5uj	236	19	Identification	identification	NN
cord-263645-wupre5uj	236	20	and	and	CC
cord-263645-wupre5uj	236	21	analysis	analysis	NN
cord-263645-wupre5uj	236	22	of	of	IN
cord-263645-wupre5uj	236	23	functional	functional	JJ
cord-263645-wupre5uj	236	24	elements	element	NNS
cord-263645-wupre5uj	236	25	in	in	IN
cord-263645-wupre5uj	236	26	1	1	CD
cord-263645-wupre5uj	236	27	%	%	NN
cord-263645-wupre5uj	236	28	of	of	IN
cord-263645-wupre5uj	236	29	the	the	DT
cord-263645-wupre5uj	236	30	human	human	JJ
cord-263645-wupre5uj	236	31	genome	genome	NN
cord-263645-wupre5uj	236	32	by	by	IN
cord-263645-wupre5uj	236	33	the	the	DT
cord-263645-wupre5uj	236	34	ENCODE	encode	NN
cord-263645-wupre5uj	236	35	pilot	pilot	NN
cord-263645-wupre5uj	236	36	project	project	NN
cord-263645-wupre5uj	236	37	Non	Non	NNP
cord-263645-wupre5uj	236	38	-	-	JJ
cord-263645-wupre5uj	236	39	coding	code	VBG
cord-263645-wupre5uj	236	40	RNAs	rna	NNS
cord-263645-wupre5uj	236	41	as	as	IN
cord-263645-wupre5uj	236	42	drug	drug	NN
cord-263645-wupre5uj	236	43	targets	target	NNS
cord-263645-wupre5uj	237	1	The	the	DT
cord-263645-wupre5uj	237	2	Therapeutic	therapeutic	JJ
cord-263645-wupre5uj	237	3	Targeting	targeting	NN
cord-263645-wupre5uj	237	4	of	of	IN
cord-263645-wupre5uj	237	5	Long	Long	NNP
cord-263645-wupre5uj	237	6	Noncoding	Noncoding	NNP
cord-263645-wupre5uj	237	7	RNA	RNA	NNP
cord-263645-wupre5uj	237	8	Linking	link	VBG
cord-263645-wupre5uj	237	9	RNA	rna	NN
cord-263645-wupre5uj	237	10	biology	biology	NN
cord-263645-wupre5uj	237	11	to	to	IN
cord-263645-wupre5uj	237	12	lncRNAs	lncRNAs	NNP
cord-263645-wupre5uj	237	13	Synthetic	synthetic	JJ
cord-263645-wupre5uj	237	14	Receptors	Receptors	NNPS
cord-263645-wupre5uj	237	15	for	for	IN
cord-263645-wupre5uj	237	16	Oligonucleotides	Oligonucleotides	NNP
cord-263645-wupre5uj	237	17	and	and	CC
cord-263645-wupre5uj	237	18	Nucleic	Nucleic	NNP
cord-263645-wupre5uj	237	19	Acids	acid	NNS
cord-263645-wupre5uj	237	20	Biochemical	biochemical	JJ
cord-263645-wupre5uj	237	21	methods	method	NNS
cord-263645-wupre5uj	237	22	to	to	TO
cord-263645-wupre5uj	237	23	investigate	investigate	VB
cord-263645-wupre5uj	237	24	lncRNA	lncRNA	NNP
cord-263645-wupre5uj	237	25	and	and	CC
cord-263645-wupre5uj	237	26	the	the	DT
cord-263645-wupre5uj	237	27	influence	influence	NN
cord-263645-wupre5uj	237	28	of	of	IN
cord-263645-wupre5uj	237	29	lncRNA	lncRNA	NNP
cord-263645-wupre5uj	237	30	:	:	:
cord-263645-wupre5uj	237	31	protein	protein	NN
cord-263645-wupre5uj	237	32	complexes	complex	NNS
cord-263645-wupre5uj	237	33	on	on	IN
cord-263645-wupre5uj	237	34	chromatin	chromatin	NN
cord-263645-wupre5uj	237	35	Opportunities	opportunity	NNS
cord-263645-wupre5uj	237	36	and	and	CC
cord-263645-wupre5uj	237	37	challenges	challenge	NNS
cord-263645-wupre5uj	237	38	in	in	IN
cord-263645-wupre5uj	237	39	RNA	RNA	NNP
cord-263645-wupre5uj	237	40	structural	structural	JJ
cord-263645-wupre5uj	237	41	modeling	modeling	NN
cord-263645-wupre5uj	237	42	and	and	CC
cord-263645-wupre5uj	237	43	design	design	VB
cord-263645-wupre5uj	237	44	The	the	DT
cord-263645-wupre5uj	237	45	impact	impact	NN
cord-263645-wupre5uj	237	46	of	of	IN
cord-263645-wupre5uj	237	47	chemical	chemical	JJ
cord-263645-wupre5uj	237	48	probes	probe	NNS
cord-263645-wupre5uj	237	49	in	in	IN
cord-263645-wupre5uj	237	50	drug	drug	NN
cord-263645-wupre5uj	237	51	discovery	discovery	NN
cord-263645-wupre5uj	237	52	:	:	:
cord-263645-wupre5uj	237	53	A	a	DT
cord-263645-wupre5uj	237	54	pharmaceutical	pharmaceutical	JJ
cord-263645-wupre5uj	237	55	industry	industry	NN
cord-263645-wupre5uj	237	56	perspective	perspective	NN
cord-263645-wupre5uj	237	57	Choose	choose	VB
cord-263645-wupre5uj	237	58	and	and	CC
cord-263645-wupre5uj	237	59	use	use	VB
cord-263645-wupre5uj	237	60	your	-PRON-	PRP$
cord-263645-wupre5uj	237	61	chemical	chemical	NN
cord-263645-wupre5uj	237	62	probe	probe	NN
cord-263645-wupre5uj	237	63	wisely	wisely	RB
cord-263645-wupre5uj	237	64	to	to	TO
cord-263645-wupre5uj	237	65	explore	explore	VB
cord-263645-wupre5uj	237	66	cancer	cancer	NN
cord-263645-wupre5uj	237	67	biology	biology	NN
cord-263645-wupre5uj	237	68	Comparison	comparison	NN
cord-263645-wupre5uj	237	69	of	of	IN
cord-263645-wupre5uj	237	70	small	small	JJ
cord-263645-wupre5uj	237	71	molecules	molecule	NNS
cord-263645-wupre5uj	237	72	and	and	CC
cord-263645-wupre5uj	237	73	oligonucleotides	oligonucleotide	NNS
cord-263645-wupre5uj	237	74	that	that	WDT
cord-263645-wupre5uj	237	75	target	target	VBP
cord-263645-wupre5uj	237	76	a	a	DT
cord-263645-wupre5uj	237	77	toxic	toxic	JJ
cord-263645-wupre5uj	237	78	,	,	,
cord-263645-wupre5uj	237	79	non	non	JJ
cord-263645-wupre5uj	237	80	-	-	JJ
cord-263645-wupre5uj	237	81	coding	code	VBG
cord-263645-wupre5uj	237	82	RNA	RNA	NNP
cord-263645-wupre5uj	237	83	Overcoming	overcome	VBG
cord-263645-wupre5uj	237	84	cellular	cellular	JJ
cord-263645-wupre5uj	237	85	barriers	barrier	NNS
cord-263645-wupre5uj	237	86	for	for	IN
cord-263645-wupre5uj	237	87	RNA	RNA	NNP
cord-263645-wupre5uj	237	88	therapeutics	therapeutic	NNS
cord-263645-wupre5uj	237	89	Selective	selective	JJ
cord-263645-wupre5uj	237	90	small	small	JJ
cord-263645-wupre5uj	237	91	-	-	HYPH
cord-263645-wupre5uj	237	92	molecule	molecule	NN
cord-263645-wupre5uj	237	93	inhibition	inhibition	NN
cord-263645-wupre5uj	237	94	of	of	IN
cord-263645-wupre5uj	237	95	an	an	DT
cord-263645-wupre5uj	237	96	RNA	RNA	NNP
cord-263645-wupre5uj	237	97	structural	structural	JJ
cord-263645-wupre5uj	237	98	element	element	NN
cord-263645-wupre5uj	238	1	Small	small	JJ
cord-263645-wupre5uj	238	2	molecule	molecule	NN
cord-263645-wupre5uj	238	3	inhibition	inhibition	NN
cord-263645-wupre5uj	238	4	of	of	IN
cord-263645-wupre5uj	238	5	microRNA-210	microRNA-210	NNP
cord-263645-wupre5uj	238	6	reprograms	reprogram	VBZ
cord-263645-wupre5uj	238	7	an	an	DT
cord-263645-wupre5uj	238	8	oncogenic	oncogenic	JJ
cord-263645-wupre5uj	238	9	hypoxic	hypoxic	JJ
cord-263645-wupre5uj	238	10	circuit	circuit	NN
cord-263645-wupre5uj	238	11	Design	Design	NNP
cord-263645-wupre5uj	238	12	of	of	IN
cord-263645-wupre5uj	238	13	a	a	DT
cord-263645-wupre5uj	238	14	small	small	JJ
cord-263645-wupre5uj	238	15	molecule	molecule	NN
cord-263645-wupre5uj	238	16	against	against	IN
cord-263645-wupre5uj	238	17	an	an	DT
cord-263645-wupre5uj	238	18	oncogenic	oncogenic	JJ
cord-263645-wupre5uj	238	19	noncoding	noncoding	JJ
cord-263645-wupre5uj	238	20	RNA	RNA	NNP
cord-263645-wupre5uj	238	21	SMN2	SMN2	NNP
cord-263645-wupre5uj	238	22	splice	splice	NN
cord-263645-wupre5uj	238	23	modulators	modulator	NNS
cord-263645-wupre5uj	238	24	enhance	enhance	VBP
cord-263645-wupre5uj	238	25	U1-pre	U1-pre	NNP
cord-263645-wupre5uj	238	26	-	-	HYPH
cord-263645-wupre5uj	238	27	mRNA	mRNA	NNP
cord-263645-wupre5uj	238	28	association	association	NN
cord-263645-wupre5uj	238	29	and	and	CC
cord-263645-wupre5uj	238	30	rescue	rescue	VB
cord-263645-wupre5uj	238	31	SMA	SMA	NNP
cord-263645-wupre5uj	238	32	mice	mouse	NNS
cord-263645-wupre5uj	238	33	Discovery	Discovery	NNP
cord-263645-wupre5uj	238	34	of	of	IN
cord-263645-wupre5uj	238	35	small	small	JJ
cord-263645-wupre5uj	238	36	molecules	molecule	NNS
cord-263645-wupre5uj	238	37	for	for	IN
cord-263645-wupre5uj	238	38	repressing	repress	VBG
cord-263645-wupre5uj	238	39	cap	cap	NN
cord-263645-wupre5uj	238	40	-	-	HYPH
cord-263645-wupre5uj	238	41	independent	independent	JJ
cord-263645-wupre5uj	238	42	translation	translation	NN
cord-263645-wupre5uj	238	43	of	of	IN
cord-263645-wupre5uj	238	44	Human	Human	NNP
cord-263645-wupre5uj	238	45	Vascular	Vascular	NNP
cord-263645-wupre5uj	238	46	Endothelial	Endothelial	NNP
cord-263645-wupre5uj	238	47	Growth	Growth	NNP
cord-263645-wupre5uj	238	48	Factor	Factor	NNP
cord-263645-wupre5uj	238	49	(	(	-LRB-
cord-263645-wupre5uj	238	50	hVEGF	hVEGF	NNP
cord-263645-wupre5uj	238	51	)	)	-RRB-
cord-263645-wupre5uj	238	52	as	as	IN
cord-263645-wupre5uj	238	53	novel	novel	JJ
cord-263645-wupre5uj	238	54	antitumor	antitumor	NN
cord-263645-wupre5uj	238	55	agents	agent	NNS
cord-263645-wupre5uj	238	56	Rationally	rationally	RB
cord-263645-wupre5uj	238	57	designed	design	VBD
cord-263645-wupre5uj	238	58	small	small	JJ
cord-263645-wupre5uj	238	59	molecules	molecule	NNS
cord-263645-wupre5uj	238	60	that	that	WDT
cord-263645-wupre5uj	238	61	target	target	VBP
cord-263645-wupre5uj	238	62	both	both	CC
cord-263645-wupre5uj	238	63	the	the	DT
cord-263645-wupre5uj	238	64	DNA	DNA	NNP
cord-263645-wupre5uj	238	65	and	and	CC
cord-263645-wupre5uj	238	66	RNA	RNA	NNP
cord-263645-wupre5uj	238	67	causing	cause	VBG
cord-263645-wupre5uj	238	68	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	238	69	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	238	70	Type	Type	NNP
cord-263645-wupre5uj	238	71	1	1	CD
cord-263645-wupre5uj	238	72	Features	feature	NNS
cord-263645-wupre5uj	238	73	of	of	IN
cord-263645-wupre5uj	238	74	modularly	modularly	RB
cord-263645-wupre5uj	238	75	assembled	assemble	VBN
cord-263645-wupre5uj	238	76	compounds	compound	NNS
cord-263645-wupre5uj	238	77	that	that	WDT
cord-263645-wupre5uj	238	78	impart	impart	VBP
cord-263645-wupre5uj	238	79	bioactivity	bioactivity	NN
cord-263645-wupre5uj	238	80	against	against	IN
cord-263645-wupre5uj	238	81	an	an	DT
cord-263645-wupre5uj	238	82	RNA	RNA	NNP
cord-263645-wupre5uj	238	83	target	target	NN
cord-263645-wupre5uj	238	84	Discovery	discovery	NN
cord-263645-wupre5uj	238	85	of	of	IN
cord-263645-wupre5uj	238	86	key	key	JJ
cord-263645-wupre5uj	238	87	physicochemical	physicochemical	JJ
cord-263645-wupre5uj	238	88	,	,	,
cord-263645-wupre5uj	238	89	structural	structural	JJ
cord-263645-wupre5uj	238	90	,	,	,
cord-263645-wupre5uj	238	91	and	and	CC
cord-263645-wupre5uj	238	92	spatial	spatial	JJ
cord-263645-wupre5uj	238	93	properties	property	NNS
cord-263645-wupre5uj	238	94	of	of	IN
cord-263645-wupre5uj	238	95	RNA	RNA	NNP
cord-263645-wupre5uj	238	96	-	-	HYPH
cord-263645-wupre5uj	238	97	targeted	target	VBN
cord-263645-wupre5uj	238	98	bioactive	bioactive	JJ
cord-263645-wupre5uj	238	99	ligands	ligand	NNS
cord-263645-wupre5uj	238	100	Small	small	JJ
cord-263645-wupre5uj	238	101	molecules	molecule	NNS
cord-263645-wupre5uj	238	102	targeting	target	VBG
cord-263645-wupre5uj	238	103	viral	viral	JJ
cord-263645-wupre5uj	238	104	RNA	RNA	NNP
cord-263645-wupre5uj	238	105	Targeting	Targeting	NNP
cord-263645-wupre5uj	238	106	RNA	RNA	NNP
cord-263645-wupre5uj	238	107	with	with	IN
cord-263645-wupre5uj	238	108	small	small	JJ
cord-263645-wupre5uj	238	109	molecules	molecule	NNS
cord-263645-wupre5uj	238	110	Chemical	chemical	JJ
cord-263645-wupre5uj	238	111	and	and	CC
cord-263645-wupre5uj	238	112	functional	functional	JJ
cord-263645-wupre5uj	238	113	diversity	diversity	NN
cord-263645-wupre5uj	238	114	of	of	IN
cord-263645-wupre5uj	238	115	small	small	JJ
cord-263645-wupre5uj	238	116	molecule	molecule	NN
cord-263645-wupre5uj	238	117	ligands	ligand	NNS
cord-263645-wupre5uj	238	118	for	for	IN
cord-263645-wupre5uj	238	119	RNA	RNA	NNP
cord-263645-wupre5uj	239	1	The	the	DT
cord-263645-wupre5uj	239	2	medicinal	medicinal	JJ
cord-263645-wupre5uj	239	3	chemistry	chemistry	NN
cord-263645-wupre5uj	239	4	of	of	IN
cord-263645-wupre5uj	239	5	peptides	peptide	NNS
cord-263645-wupre5uj	240	1	The	the	DT
cord-263645-wupre5uj	240	2	medicinal	medicinal	JJ
cord-263645-wupre5uj	240	3	chemistry	chemistry	NN
cord-263645-wupre5uj	240	4	of	of	IN
cord-263645-wupre5uj	240	5	therapeutic	therapeutic	JJ
cord-263645-wupre5uj	240	6	oligonucleotides	oligonucleotide	NNS
cord-263645-wupre5uj	240	7	Inhibitors	Inhibitors	NNPS
cord-263645-wupre5uj	240	8	of	of	IN
cord-263645-wupre5uj	240	9	protein	protein	NN
cord-263645-wupre5uj	240	10	-	-	HYPH
cord-263645-wupre5uj	240	11	RNA	RNA	NNP
cord-263645-wupre5uj	240	12	complexation	complexation	NN
cord-263645-wupre5uj	240	13	that	that	WDT
cord-263645-wupre5uj	240	14	target	target	VBP
cord-263645-wupre5uj	240	15	the	the	DT
cord-263645-wupre5uj	240	16	RNA	rna	NN
cord-263645-wupre5uj	240	17	:	:	:
cord-263645-wupre5uj	240	18	Specific	specific	JJ
cord-263645-wupre5uj	240	19	recognition	recognition	NN
cord-263645-wupre5uj	240	20	of	of	IN
cord-263645-wupre5uj	240	21	Human	Human	NNP
cord-263645-wupre5uj	240	22	Immunodeficiency	Immunodeficiency	NNP
cord-263645-wupre5uj	240	23	Virus	Virus	NNP
cord-263645-wupre5uj	240	24	Type	Type	NNP
cord-263645-wupre5uj	240	25	1	1	CD
cord-263645-wupre5uj	240	26	TAR	tar	NN
cord-263645-wupre5uj	240	27	RNA	RNA	NNP
cord-263645-wupre5uj	240	28	by	by	IN
cord-263645-wupre5uj	240	29	small	small	JJ
cord-263645-wupre5uj	240	30	organic	organic	JJ
cord-263645-wupre5uj	240	31	molecules	molecule	NNS
cord-263645-wupre5uj	241	1	New	new	JJ
cord-263645-wupre5uj	241	2	anti	anti	JJ
cord-263645-wupre5uj	241	3	-	-	JJ
cord-263645-wupre5uj	241	4	Human	human	JJ
cord-263645-wupre5uj	241	5	Immunodeficiency	Immunodeficiency	NNP
cord-263645-wupre5uj	241	6	Virus	Virus	NNP
cord-263645-wupre5uj	241	7	Type	type	NN
cord-263645-wupre5uj	242	1	1	1	CD
cord-263645-wupre5uj	242	2	6-aminoquinolones	6-aminoquinolones	CD
cord-263645-wupre5uj	242	3	:	:	:
cord-263645-wupre5uj	243	1	Mechanism	mechanism	NN
cord-263645-wupre5uj	243	2	of	of	IN
cord-263645-wupre5uj	243	3	action	action	NN
cord-263645-wupre5uj	243	4	)	)	-RRB-
cord-263645-wupre5uj	243	5	6-Aminoquinolones	6-aminoquinolones	CD
cord-263645-wupre5uj	243	6	as	as	IN
cord-263645-wupre5uj	243	7	new	new	JJ
cord-263645-wupre5uj	243	8	potential	potential	JJ
cord-263645-wupre5uj	243	9	anti	anti	JJ
cord-263645-wupre5uj	243	10	-	-	JJ
cord-263645-wupre5uj	243	11	HIV	hiv	JJ
cord-263645-wupre5uj	243	12	agents	agent	NNS
cord-263645-wupre5uj	244	1	Pentamidine	Pentamidine	NNP
cord-263645-wupre5uj	244	2	inhibition	inhibition	NN
cord-263645-wupre5uj	244	3	of	of	IN
cord-263645-wupre5uj	244	4	group	group	NN
cord-263645-wupre5uj	244	5	I	-PRON-	PRP
cord-263645-wupre5uj	244	6	intron	intron	NN
cord-263645-wupre5uj	244	7	splicing	splice	VBG
cord-263645-wupre5uj	244	8	in	in	IN
cord-263645-wupre5uj	244	9	Candida	Candida	NNP
cord-263645-wupre5uj	244	10	albicans	albican	NNS
cord-263645-wupre5uj	244	11	correlates	correlate	VBZ
cord-263645-wupre5uj	244	12	with	with	IN
cord-263645-wupre5uj	244	13	growth	growth	NN
cord-263645-wupre5uj	244	14	inhibition	inhibition	NN
cord-263645-wupre5uj	244	15	Rational	rational	JJ
cord-263645-wupre5uj	244	16	design	design	NN
cord-263645-wupre5uj	244	17	of	of	IN
cord-263645-wupre5uj	244	18	chemical	chemical	JJ
cord-263645-wupre5uj	244	19	genetic	genetic	JJ
cord-263645-wupre5uj	244	20	probes	probe	NNS
cord-263645-wupre5uj	244	21	of	of	IN
cord-263645-wupre5uj	244	22	RNA	RNA	NNP
cord-263645-wupre5uj	244	23	function	function	NN
cord-263645-wupre5uj	244	24	and	and	CC
cord-263645-wupre5uj	244	25	lead	lead	VB
cord-263645-wupre5uj	244	26	therapeutics	therapeutic	NNS
cord-263645-wupre5uj	244	27	targeting	target	VBG
cord-263645-wupre5uj	244	28	repeating	repeat	VBG
cord-263645-wupre5uj	244	29	transcripts	transcript	NNS
cord-263645-wupre5uj	244	30	Recognition	Recognition	NNP
cord-263645-wupre5uj	244	31	of	of	IN
cord-263645-wupre5uj	244	32	nucleic	nucleic	JJ
cord-263645-wupre5uj	244	33	acid	acid	NN
cord-263645-wupre5uj	244	34	junctions	junction	NNS
cord-263645-wupre5uj	244	35	using	use	VBG
cord-263645-wupre5uj	244	36	triptycene	triptycene	NN
cord-263645-wupre5uj	244	37	-	-	HYPH
cord-263645-wupre5uj	244	38	based	base	VBN
cord-263645-wupre5uj	244	39	molecules	molecule	NNS
cord-263645-wupre5uj	244	40	Modulation	modulation	NN
cord-263645-wupre5uj	244	41	of	of	IN
cord-263645-wupre5uj	244	42	the	the	DT
cord-263645-wupre5uj	244	43	E.	E.	NNP
cord-263645-wupre5uj	244	44	coli	coli	NNS
cord-263645-wupre5uj	244	45	rpoH	rpoH	NNP
cord-263645-wupre5uj	244	46	temperature	temperature	NN
cord-263645-wupre5uj	244	47	sensor	sensor	NN
cord-263645-wupre5uj	244	48	with	with	IN
cord-263645-wupre5uj	244	49	triptycene	triptycene	NN
cord-263645-wupre5uj	244	50	-	-	HYPH
cord-263645-wupre5uj	244	51	based	base	VBN
cord-263645-wupre5uj	244	52	small	small	JJ
cord-263645-wupre5uj	244	53	molecules	molecule	NNS
cord-263645-wupre5uj	245	1	Recent	recent	JJ
cord-263645-wupre5uj	245	2	developments	development	NNS
cord-263645-wupre5uj	245	3	in	in	IN
cord-263645-wupre5uj	245	4	focused	focused	JJ
cord-263645-wupre5uj	245	5	library	library	NN
cord-263645-wupre5uj	245	6	design	design	NN
cord-263645-wupre5uj	245	7	:	:	:
cord-263645-wupre5uj	246	1	Targeting	target	VBG
cord-263645-wupre5uj	246	2	gene	gene	NN
cord-263645-wupre5uj	246	3	-	-	HYPH
cord-263645-wupre5uj	246	4	families	family	NNS
cord-263645-wupre5uj	247	1	The	the	DT
cord-263645-wupre5uj	247	2	design	design	NN
cord-263645-wupre5uj	247	3	and	and	CC
cord-263645-wupre5uj	247	4	application	application	NN
cord-263645-wupre5uj	247	5	of	of	IN
cord-263645-wupre5uj	247	6	target	target	NN
cord-263645-wupre5uj	247	7	-	-	HYPH
cord-263645-wupre5uj	247	8	focused	focus	VBN
cord-263645-wupre5uj	247	9	compound	compound	NN
cord-263645-wupre5uj	247	10	libraries	library	NNS
cord-263645-wupre5uj	248	1	Recent	recent	JJ
cord-263645-wupre5uj	248	2	advances	advance	NNS
cord-263645-wupre5uj	248	3	in	in	IN
cord-263645-wupre5uj	248	4	developing	develop	VBG
cord-263645-wupre5uj	248	5	small	small	JJ
cord-263645-wupre5uj	248	6	molecules	molecule	NNS
cord-263645-wupre5uj	248	7	targeting	target	VBG
cord-263645-wupre5uj	248	8	RNA	RNA	NNP
cord-263645-wupre5uj	248	9	Insights	Insights	NNP
cord-263645-wupre5uj	248	10	into	into	IN
cord-263645-wupre5uj	248	11	RNA	RNA	NNP
cord-263645-wupre5uj	248	12	structure	structure	NN
cord-263645-wupre5uj	248	13	and	and	CC
cord-263645-wupre5uj	248	14	function	function	NN
cord-263645-wupre5uj	248	15	from	from	IN
cord-263645-wupre5uj	248	16	genome	genome	NN
cord-263645-wupre5uj	248	17	-	-	HYPH
cord-263645-wupre5uj	248	18	wide	wide	JJ
cord-263645-wupre5uj	248	19	studies	study	NNS
cord-263645-wupre5uj	248	20	Inforna	Inforna	NNP
cord-263645-wupre5uj	248	21	2.0	2.0	CD
cord-263645-wupre5uj	248	22	:	:	:
cord-263645-wupre5uj	249	1	A	a	DT
cord-263645-wupre5uj	249	2	platform	platform	NN
cord-263645-wupre5uj	249	3	for	for	IN
cord-263645-wupre5uj	249	4	the	the	DT
cord-263645-wupre5uj	249	5	sequence	sequence	NN
cord-263645-wupre5uj	249	6	-	-	HYPH
cord-263645-wupre5uj	249	7	based	base	VBN
cord-263645-wupre5uj	249	8	design	design	NN
cord-263645-wupre5uj	249	9	of	of	IN
cord-263645-wupre5uj	249	10	small	small	JJ
cord-263645-wupre5uj	249	11	molecules	molecule	NNS
cord-263645-wupre5uj	249	12	targeting	target	VBG
cord-263645-wupre5uj	249	13	structured	structured	JJ
cord-263645-wupre5uj	249	14	RNAs	rna	NNS
cord-263645-wupre5uj	249	15	Identifying	identify	VBG
cord-263645-wupre5uj	249	16	the	the	DT
cord-263645-wupre5uj	249	17	preferred	prefer	VBN
cord-263645-wupre5uj	249	18	RNA	RNA	NNP
cord-263645-wupre5uj	249	19	motifs	motif	NNS
cord-263645-wupre5uj	249	20	and	and	CC
cord-263645-wupre5uj	249	21	chemotypes	chemotype	NNS
cord-263645-wupre5uj	249	22	that	that	WDT
cord-263645-wupre5uj	249	23	interact	interact	VBP
cord-263645-wupre5uj	249	24	by	by	IN
cord-263645-wupre5uj	249	25	probing	probe	VBG
cord-263645-wupre5uj	249	26	millions	million	NNS
cord-263645-wupre5uj	249	27	of	of	IN
cord-263645-wupre5uj	249	28	combinations	combination	NNS
cord-263645-wupre5uj	249	29	Twenty	twenty	CD
cord-263645-wupre5uj	249	30	years	year	NNS
cord-263645-wupre5uj	249	31	on	on	IN
cord-263645-wupre5uj	249	32	:	:	:
cord-263645-wupre5uj	249	33	The	the	DT
cord-263645-wupre5uj	249	34	impact	impact	NN
cord-263645-wupre5uj	249	35	of	of	IN
cord-263645-wupre5uj	249	36	fragments	fragment	NNS
cord-263645-wupre5uj	249	37	on	on	IN
cord-263645-wupre5uj	249	38	drug	drug	NN
cord-263645-wupre5uj	249	39	discovery	discovery	NN
cord-263645-wupre5uj	249	40	A	a	DT
cord-263645-wupre5uj	249	41	novel	novel	JJ
cord-263645-wupre5uj	249	42	small	small	JJ
cord-263645-wupre5uj	249	43	-	-	HYPH
cord-263645-wupre5uj	249	44	molecule	molecule	NN
cord-263645-wupre5uj	249	45	binds	bind	VBZ
cord-263645-wupre5uj	249	46	to	to	IN
cord-263645-wupre5uj	249	47	the	the	DT
cord-263645-wupre5uj	249	48	Influenza	Influenza	NNP
cord-263645-wupre5uj	249	49	A	A	NNP
cord-263645-wupre5uj	249	50	Virus	Virus	NNP
cord-263645-wupre5uj	249	51	RNA	RNA	NNP
cord-263645-wupre5uj	249	52	Promoter	Promoter	NNP
cord-263645-wupre5uj	249	53	and	and	CC
cord-263645-wupre5uj	249	54	inhibits	inhibit	VBZ
cord-263645-wupre5uj	249	55	viral	viral	JJ
cord-263645-wupre5uj	249	56	replication	replication	NN
cord-263645-wupre5uj	250	1	Targeting	target	VBG
cord-263645-wupre5uj	250	2	influenza	influenza	NN
cord-263645-wupre5uj	250	3	A	a	DT
cord-263645-wupre5uj	250	4	virus	virus	NN
cord-263645-wupre5uj	250	5	RNA	rna	NN
cord-263645-wupre5uj	250	6	promoter	promoter	NN
cord-263645-wupre5uj	250	7	for	for	IN
cord-263645-wupre5uj	250	8	up	up	RB
cord-263645-wupre5uj	250	9	-	-	HYPH
cord-263645-wupre5uj	250	10	regulating	regulate	VBG
cord-263645-wupre5uj	250	11	the	the	DT
cord-263645-wupre5uj	250	12	translation	translation	NN
cord-263645-wupre5uj	250	13	of	of	IN
cord-263645-wupre5uj	250	14	Antiamyloidogenic	Antiamyloidogenic	NNP
cord-263645-wupre5uj	250	15	Secretase	Secretase	NNP
cord-263645-wupre5uj	250	16	,	,	,
cord-263645-wupre5uj	250	17	a	a	DT
cord-263645-wupre5uj	250	18	Disintegrin	Disintegrin	NNP
cord-263645-wupre5uj	250	19	and	and	CC
cord-263645-wupre5uj	250	20	Metalloproteinase	Metalloproteinase	NNP
cord-263645-wupre5uj	250	21	10	10	CD
cord-263645-wupre5uj	250	22	(	(	-LRB-
cord-263645-wupre5uj	250	23	ADAM10	ADAM10	NNP
cord-263645-wupre5uj	250	24	)	)	-RRB-
cord-263645-wupre5uj	250	25	,	,	,
cord-263645-wupre5uj	250	26	by	by	IN
cord-263645-wupre5uj	250	27	binding	bind	VBG
cord-263645-wupre5uj	250	28	to	to	IN
cord-263645-wupre5uj	250	29	the	the	DT
cord-263645-wupre5uj	250	30	G	G	NNP
cord-263645-wupre5uj	250	31	-	-	HYPH
cord-263645-wupre5uj	250	32	quadruplex	quadruplex	NN
cord-263645-wupre5uj	250	33	-	-	HYPH
cord-263645-wupre5uj	250	34	forming	form	VBG
cord-263645-wupre5uj	250	35	sequence	sequence	NN
cord-263645-wupre5uj	250	36	in	in	IN
cord-263645-wupre5uj	250	37	the	the	DT
cord-263645-wupre5uj	250	38	5	5	CD
cord-263645-wupre5uj	250	39	untranslated	untranslated	JJ
cord-263645-wupre5uj	250	40	region	region	NN
cord-263645-wupre5uj	250	41	(	(	-LRB-
cord-263645-wupre5uj	250	42	UTR	UTR	NNP
cord-263645-wupre5uj	250	43	)	)	-RRB-
cord-263645-wupre5uj	250	44	of	of	IN
cord-263645-wupre5uj	250	45	its	-PRON-	PRP$
cord-263645-wupre5uj	250	46	mRNA	mrna	NN
cord-263645-wupre5uj	251	1	Studying	study	VBG
cord-263645-wupre5uj	251	2	a	a	DT
cord-263645-wupre5uj	251	3	drug	drug	NN
cord-263645-wupre5uj	251	4	-	-	HYPH
cord-263645-wupre5uj	251	5	like	like	JJ
cord-263645-wupre5uj	251	6	,	,	,
cord-263645-wupre5uj	251	7	RNA	RNA	NNP
cord-263645-wupre5uj	251	8	-	-	HYPH
cord-263645-wupre5uj	251	9	focused	focus	VBN
cord-263645-wupre5uj	251	10	small	small	JJ
cord-263645-wupre5uj	251	11	molecule	molecule	NN
cord-263645-wupre5uj	251	12	library	library	NN
cord-263645-wupre5uj	251	13	identifies	identify	VBZ
cord-263645-wupre5uj	251	14	compounds	compound	NNS
cord-263645-wupre5uj	251	15	that	that	WDT
cord-263645-wupre5uj	251	16	inhibit	inhibit	VBP
cord-263645-wupre5uj	251	17	RNA	rna	NN
cord-263645-wupre5uj	251	18	toxicity	toxicity	NN
cord-263645-wupre5uj	251	19	in	in	IN
cord-263645-wupre5uj	251	20	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	251	21	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	251	22	Novel	Novel	NNP
cord-263645-wupre5uj	251	23	riboswitch	riboswitch	NN
cord-263645-wupre5uj	251	24	ligand	ligand	NN
cord-263645-wupre5uj	251	25	analogs	analog	NNS
cord-263645-wupre5uj	251	26	as	as	IN
cord-263645-wupre5uj	251	27	selective	selective	JJ
cord-263645-wupre5uj	251	28	inhibitors	inhibitor	NNS
cord-263645-wupre5uj	251	29	of	of	IN
cord-263645-wupre5uj	251	30	guanine	guanine	NN
cord-263645-wupre5uj	251	31	-	-	HYPH
cord-263645-wupre5uj	251	32	related	relate	VBN
cord-263645-wupre5uj	251	33	metabolic	metabolic	JJ
cord-263645-wupre5uj	251	34	pathways	pathway	NNS
cord-263645-wupre5uj	251	35	Chemical	Chemical	NNP
cord-263645-wupre5uj	251	36	correction	correction	NN
cord-263645-wupre5uj	251	37	of	of	IN
cord-263645-wupre5uj	251	38	pre	pre	JJ
cord-263645-wupre5uj	251	39	-	-	JJ
cord-263645-wupre5uj	251	40	mRNA	mrna	JJ
cord-263645-wupre5uj	251	41	splicing	splicing	NN
cord-263645-wupre5uj	251	42	defects	defect	NNS
cord-263645-wupre5uj	251	43	associated	associate	VBN
cord-263645-wupre5uj	251	44	with	with	IN
cord-263645-wupre5uj	251	45	sequestration	sequestration	NN
cord-263645-wupre5uj	251	46	of	of	IN
cord-263645-wupre5uj	251	47	muscleblind	muscleblind	JJ
cord-263645-wupre5uj	251	48	-	-	HYPH
cord-263645-wupre5uj	251	49	like	like	JJ
cord-263645-wupre5uj	251	50	1	1	CD
cord-263645-wupre5uj	251	51	protein	protein	NN
cord-263645-wupre5uj	251	52	by	by	IN
cord-263645-wupre5uj	251	53	expanded	expand	VBN
cord-263645-wupre5uj	251	54	r(CAG)-containing	r(cag)-containing	IN
cord-263645-wupre5uj	251	55	transcripts	transcript	NNS
cord-263645-wupre5uj	251	56	Structure	Structure	NNP
cord-263645-wupre5uj	251	57	-	-	HYPH
cord-263645-wupre5uj	251	58	based	base	VBN
cord-263645-wupre5uj	251	59	design	design	NN
cord-263645-wupre5uj	251	60	of	of	IN
cord-263645-wupre5uj	251	61	an	an	DT
cord-263645-wupre5uj	251	62	RNA	RNA	NNP
cord-263645-wupre5uj	251	63	-	-	HYPH
cord-263645-wupre5uj	251	64	binding	bind	VBG
cord-263645-wupre5uj	251	65	p	p	NN
cord-263645-wupre5uj	251	66	-	-	HYPH
cord-263645-wupre5uj	251	67	terphenylene	terphenylene	NN
cord-263645-wupre5uj	251	68	scaffold	scaffold	NN
cord-263645-wupre5uj	251	69	that	that	WDT
cord-263645-wupre5uj	251	70	inhibits	inhibit	VBZ
cord-263645-wupre5uj	251	71	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	251	72	Rev	Rev	NNP
cord-263645-wupre5uj	251	73	protein	protein	NN
cord-263645-wupre5uj	251	74	function	function	NN
cord-263645-wupre5uj	252	1	Targeting	target	VBG
cord-263645-wupre5uj	252	2	RNA	rna	NN
cord-263645-wupre5uj	252	3	-	-	HYPH
cord-263645-wupre5uj	252	4	protein	protein	NN
cord-263645-wupre5uj	252	5	interactions	interaction	NNS
cord-263645-wupre5uj	252	6	within	within	IN
cord-263645-wupre5uj	252	7	the	the	DT
cord-263645-wupre5uj	252	8	Human	Human	NNP
cord-263645-wupre5uj	252	9	Immunodeficiency	Immunodeficiency	NNP
cord-263645-wupre5uj	252	10	Virus	Virus	NNP
cord-263645-wupre5uj	252	11	Type	Type	NNP
cord-263645-wupre5uj	252	12	1	1	CD
cord-263645-wupre5uj	252	13	lifecycle	lifecycle	NN
cord-263645-wupre5uj	253	1	A	a	DT
cord-263645-wupre5uj	253	2	small	small	JJ
cord-263645-wupre5uj	253	3	molecule	molecule	NN
cord-263645-wupre5uj	253	4	that	that	WDT
cord-263645-wupre5uj	253	5	represses	repress	VBZ
cord-263645-wupre5uj	253	6	translation	translation	NN
cord-263645-wupre5uj	253	7	of	of	IN
cord-263645-wupre5uj	253	8	G	g	NN
cord-263645-wupre5uj	253	9	-	-	HYPH
cord-263645-wupre5uj	253	10	quadruplex	quadruplex	NN
cord-263645-wupre5uj	253	11	-	-	HYPH
cord-263645-wupre5uj	253	12	containing	contain	VBG
cord-263645-wupre5uj	253	13	mRNA	mRNA	NNP
cord-263645-wupre5uj	253	14	Thermodynamic	Thermodynamic	NNP
cord-263645-wupre5uj	253	15	studies	study	NNS
cord-263645-wupre5uj	253	16	of	of	IN
cord-263645-wupre5uj	253	17	a	a	DT
cord-263645-wupre5uj	253	18	series	series	NN
cord-263645-wupre5uj	253	19	of	of	IN
cord-263645-wupre5uj	253	20	homologous	homologous	JJ
cord-263645-wupre5uj	253	21	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	253	22	TAR	TAR	NNP
cord-263645-wupre5uj	253	23	RNA	RNA	NNP
cord-263645-wupre5uj	253	24	ligands	ligand	NNS
cord-263645-wupre5uj	253	25	reveal	reveal	VBP
cord-263645-wupre5uj	253	26	that	that	IN
cord-263645-wupre5uj	253	27	loose	loose	JJ
cord-263645-wupre5uj	253	28	binders	binder	NNS
cord-263645-wupre5uj	253	29	are	be	VBP
cord-263645-wupre5uj	253	30	stronger	strong	JJR
cord-263645-wupre5uj	253	31	Tat	Tat	NNP
cord-263645-wupre5uj	253	32	competitors	competitor	NNS
cord-263645-wupre5uj	253	33	than	than	IN
cord-263645-wupre5uj	253	34	tight	tight	JJ
cord-263645-wupre5uj	253	35	ones	one	NNS
cord-263645-wupre5uj	253	36	Development	Development	NNP
cord-263645-wupre5uj	253	37	of	of	IN
cord-263645-wupre5uj	253	38	small	small	JJ
cord-263645-wupre5uj	253	39	molecules	molecule	NNS
cord-263645-wupre5uj	253	40	with	with	IN
cord-263645-wupre5uj	253	41	a	a	DT
cord-263645-wupre5uj	253	42	noncanonical	noncanonical	JJ
cord-263645-wupre5uj	253	43	binding	binding	NN
cord-263645-wupre5uj	253	44	mode	mode	NN
cord-263645-wupre5uj	253	45	to	to	IN
cord-263645-wupre5uj	253	46	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	253	47	Trans	Trans	NNP
cord-263645-wupre5uj	253	48	Activation	Activation	NNP
cord-263645-wupre5uj	253	49	Response	Response	NNP
cord-263645-wupre5uj	253	50	(	(	-LRB-
cord-263645-wupre5uj	253	51	TAR	tar	NN
cord-263645-wupre5uj	253	52	)	)	-RRB-
cord-263645-wupre5uj	254	1	RNA	RNA	NNP
cord-263645-wupre5uj	254	2	Pyrvinium	Pyrvinium	NNP
cord-263645-wupre5uj	254	3	pamoate	pamoate	NN
cord-263645-wupre5uj	254	4	changes	change	VBZ
cord-263645-wupre5uj	254	5	alternative	alternative	JJ
cord-263645-wupre5uj	254	6	splicing	splicing	NN
cord-263645-wupre5uj	254	7	of	of	IN
cord-263645-wupre5uj	254	8	the	the	DT
cord-263645-wupre5uj	254	9	Serotonin	Serotonin	NNP
cord-263645-wupre5uj	254	10	Receptor	Receptor	NNP
cord-263645-wupre5uj	254	11	2C	2c	NN
cord-263645-wupre5uj	254	12	by	by	IN
cord-263645-wupre5uj	254	13	influencing	influence	VBG
cord-263645-wupre5uj	254	14	its	-PRON-	PRP$
cord-263645-wupre5uj	254	15	RNA	RNA	NNP
cord-263645-wupre5uj	254	16	structure	structure	NN
cord-263645-wupre5uj	254	17	Structure	structure	NN
cord-263645-wupre5uj	254	18	-	-	HYPH
cord-263645-wupre5uj	254	19	based	base	VBN
cord-263645-wupre5uj	254	20	computational	computational	JJ
cord-263645-wupre5uj	254	21	database	database	NN
cord-263645-wupre5uj	254	22	screening	screening	NN
cord-263645-wupre5uj	254	23	,	,	,
cord-263645-wupre5uj	254	24	in	in	IN
cord-263645-wupre5uj	254	25	vitro	vitro	FW
cord-263645-wupre5uj	254	26	assay	assay	NN
cord-263645-wupre5uj	254	27	,	,	,
cord-263645-wupre5uj	254	28	and	and	CC
cord-263645-wupre5uj	254	29	NMR	NMR	NNP
cord-263645-wupre5uj	254	30	assessment	assessment	NN
cord-263645-wupre5uj	254	31	of	of	IN
cord-263645-wupre5uj	254	32	compounds	compound	NNS
cord-263645-wupre5uj	254	33	that	that	WDT
cord-263645-wupre5uj	254	34	target	target	VBP
cord-263645-wupre5uj	254	35	TAR	TAR	NNP
cord-263645-wupre5uj	254	36	RNA	RNA	NNP
cord-263645-wupre5uj	254	37	Identification	Identification	NNP
cord-263645-wupre5uj	254	38	of	of	IN
cord-263645-wupre5uj	254	39	RNA	RNA	NNP
cord-263645-wupre5uj	254	40	pseudoknot	pseudoknot	NN
cord-263645-wupre5uj	254	41	-	-	HYPH
cord-263645-wupre5uj	254	42	binding	bind	VBG
cord-263645-wupre5uj	254	43	ligand	ligand	NN
cord-263645-wupre5uj	254	44	that	that	WDT
cord-263645-wupre5uj	254	45	inhibits	inhibit	VBZ
cord-263645-wupre5uj	254	46	the	the	DT
cord-263645-wupre5uj	254	47	-1	-1	NN
cord-263645-wupre5uj	254	48	ribosomal	ribosomal	JJ
cord-263645-wupre5uj	254	49	frameshifting	frameshifting	NN
cord-263645-wupre5uj	254	50	of	of	IN
cord-263645-wupre5uj	254	51	SARS	SARS	NNP
cord-263645-wupre5uj	254	52	-	-	HYPH
cord-263645-wupre5uj	254	53	coronavirus	coronavirus	NN
cord-263645-wupre5uj	254	54	by	by	IN
cord-263645-wupre5uj	254	55	structure	structure	NN
cord-263645-wupre5uj	254	56	-	-	HYPH
cord-263645-wupre5uj	254	57	based	base	VBN
cord-263645-wupre5uj	254	58	virtual	virtual	JJ
cord-263645-wupre5uj	254	59	screening	screening	NN
cord-263645-wupre5uj	254	60	Structure	structure	NN
cord-263645-wupre5uj	254	61	based	base	VBN
cord-263645-wupre5uj	254	62	approaches	approach	NNS
cord-263645-wupre5uj	254	63	for	for	IN
cord-263645-wupre5uj	254	64	targeting	target	VBG
cord-263645-wupre5uj	254	65	non	non	JJ
cord-263645-wupre5uj	254	66	-	-	JJ
cord-263645-wupre5uj	254	67	coding	coding	JJ
cord-263645-wupre5uj	254	68	RNAs	rna	NNS
cord-263645-wupre5uj	254	69	with	with	IN
cord-263645-wupre5uj	254	70	small	small	JJ
cord-263645-wupre5uj	254	71	molecules	molecule	NNS
cord-263645-wupre5uj	254	72	Structure	structure	NN
cord-263645-wupre5uj	254	73	-	-	HYPH
cord-263645-wupre5uj	254	74	based	base	VBN
cord-263645-wupre5uj	254	75	discovery	discovery	NN
cord-263645-wupre5uj	254	76	of	of	IN
cord-263645-wupre5uj	254	77	small	small	JJ
cord-263645-wupre5uj	254	78	molecules	molecule	NNS
cord-263645-wupre5uj	254	79	binding	bind	VBG
cord-263645-wupre5uj	254	80	to	to	IN
cord-263645-wupre5uj	254	81	RNA	RNA	NNP
cord-263645-wupre5uj	254	82	Bottom	Bottom	NNP
cord-263645-wupre5uj	254	83	-	-	HYPH
cord-263645-wupre5uj	254	84	up	up	RP
cord-263645-wupre5uj	254	85	design	design	NN
cord-263645-wupre5uj	254	86	of	of	IN
cord-263645-wupre5uj	254	87	small	small	JJ
cord-263645-wupre5uj	254	88	molecules	molecule	NNS
cord-263645-wupre5uj	254	89	that	that	WDT
cord-263645-wupre5uj	254	90	stimulate	stimulate	VBP
cord-263645-wupre5uj	254	91	exon	exon	NN
cord-263645-wupre5uj	254	92	10	10	CD
cord-263645-wupre5uj	254	93	skipping	skipping	NN
cord-263645-wupre5uj	254	94	in	in	IN
cord-263645-wupre5uj	254	95	mutant	mutant	JJ
cord-263645-wupre5uj	254	96	MAPT	MAPT	NNP
cord-263645-wupre5uj	254	97	pre	pre	NNP
cord-263645-wupre5uj	254	98	-	-	JJ
cord-263645-wupre5uj	254	99	mRNA	mrna	JJ
cord-263645-wupre5uj	254	100	Sequence	sequence	NN
cord-263645-wupre5uj	254	101	-	-	HYPH
cord-263645-wupre5uj	254	102	based	base	VBN
cord-263645-wupre5uj	254	103	design	design	NN
cord-263645-wupre5uj	254	104	of	of	IN
cord-263645-wupre5uj	254	105	bioactive	bioactive	JJ
cord-263645-wupre5uj	254	106	small	small	JJ
cord-263645-wupre5uj	254	107	molecules	molecule	NNS
cord-263645-wupre5uj	254	108	that	that	WDT
cord-263645-wupre5uj	254	109	target	target	VBP
cord-263645-wupre5uj	254	110	precursor	precursor	NN
cord-263645-wupre5uj	254	111	microRNAs	microrna	NNS
cord-263645-wupre5uj	255	1	Defining	define	VBG
cord-263645-wupre5uj	255	2	RNA	rna	NN
cord-263645-wupre5uj	255	3	-	-	HYPH
cord-263645-wupre5uj	255	4	small	small	JJ
cord-263645-wupre5uj	255	5	molecule	molecule	NN
cord-263645-wupre5uj	255	6	affinity	affinity	NN
cord-263645-wupre5uj	255	7	landscapes	landscape	NNS
cord-263645-wupre5uj	255	8	enables	enable	VBZ
cord-263645-wupre5uj	255	9	design	design	NN
cord-263645-wupre5uj	255	10	of	of	IN
cord-263645-wupre5uj	255	11	a	a	DT
cord-263645-wupre5uj	255	12	small	small	JJ
cord-263645-wupre5uj	255	13	molecule	molecule	NN
cord-263645-wupre5uj	255	14	inhibitor	inhibitor	NN
cord-263645-wupre5uj	255	15	of	of	IN
cord-263645-wupre5uj	255	16	an	an	DT
cord-263645-wupre5uj	255	17	oncogenic	oncogenic	JJ
cord-263645-wupre5uj	255	18	noncoding	noncoding	JJ
cord-263645-wupre5uj	255	19	RNA	RNA	NNP
cord-263645-wupre5uj	255	20	Biogenesis	Biogenesis	NNP
cord-263645-wupre5uj	255	21	Disrupts	disrupt	VBZ
cord-263645-wupre5uj	255	22	Adaptive	adaptive	JJ
cord-263645-wupre5uj	255	23	Responses	response	NNS
cord-263645-wupre5uj	255	24	to	to	IN
cord-263645-wupre5uj	255	25	Hypoxia	hypoxia	NN
cord-263645-wupre5uj	255	26	by	by	IN
cord-263645-wupre5uj	255	27	Modulating	modulate	VBG
cord-263645-wupre5uj	255	28	ATM	ATM	NNP
cord-263645-wupre5uj	255	29	-	-	HYPH
cord-263645-wupre5uj	255	30	mTOR	mtor	NN
cord-263645-wupre5uj	255	31	Signaling	signal	VBG
cord-263645-wupre5uj	255	32	Novel	Novel	NNP
cord-263645-wupre5uj	255	33	riboswitch	riboswitch	NN
cord-263645-wupre5uj	255	34	-	-	HYPH
cord-263645-wupre5uj	255	35	binding	bind	VBG
cord-263645-wupre5uj	255	36	flavin	flavin	NN
cord-263645-wupre5uj	255	37	analog	analog	NN
cord-263645-wupre5uj	255	38	that	that	WDT
cord-263645-wupre5uj	255	39	protects	protect	VBZ
cord-263645-wupre5uj	255	40	mice	mouse	NNS
cord-263645-wupre5uj	255	41	against	against	IN
cord-263645-wupre5uj	255	42	Clostridium	clostridium	NN
cord-263645-wupre5uj	255	43	difficile	difficile	NN
cord-263645-wupre5uj	255	44	infection	infection	NN
cord-263645-wupre5uj	255	45	without	without	IN
cord-263645-wupre5uj	255	46	inhibiting	inhibit	VBG
cord-263645-wupre5uj	255	47	cecal	cecal	JJ
cord-263645-wupre5uj	255	48	flora	flora	NNS
cord-263645-wupre5uj	255	49	Roseoflavin	Roseoflavin	NNPS
cord-263645-wupre5uj	255	50	is	be	VBZ
cord-263645-wupre5uj	255	51	a	a	DT
cord-263645-wupre5uj	255	52	natural	natural	JJ
cord-263645-wupre5uj	255	53	antibacterial	antibacterial	JJ
cord-263645-wupre5uj	255	54	compound	compound	NN
cord-263645-wupre5uj	255	55	that	that	WDT
cord-263645-wupre5uj	255	56	binds	bind	VBZ
cord-263645-wupre5uj	255	57	to	to	IN
cord-263645-wupre5uj	255	58	FMN	fmn	NN
cord-263645-wupre5uj	255	59	riboswitches	riboswitche	NNS
cord-263645-wupre5uj	255	60	and	and	CC
cord-263645-wupre5uj	255	61	regulates	regulate	VBZ
cord-263645-wupre5uj	255	62	gene	gene	NN
cord-263645-wupre5uj	255	63	expression	expression	NN
cord-263645-wupre5uj	255	64	Structure	structure	NN
cord-263645-wupre5uj	255	65	-	-	HYPH
cord-263645-wupre5uj	255	66	guided	guide	VBN
cord-263645-wupre5uj	255	67	mutational	mutational	JJ
cord-263645-wupre5uj	255	68	analysis	analysis	NN
cord-263645-wupre5uj	255	69	of	of	IN
cord-263645-wupre5uj	255	70	gene	gene	NN
cord-263645-wupre5uj	255	71	regulation	regulation	NN
cord-263645-wupre5uj	255	72	by	by	IN
cord-263645-wupre5uj	255	73	the	the	DT
cord-263645-wupre5uj	255	74	Bacillus	bacillus	NN
cord-263645-wupre5uj	255	75	subtilis	subtili	NNS
cord-263645-wupre5uj	255	76	pbuE	pbue	NN
cord-263645-wupre5uj	255	77	Adenine	adenine	NN
cord-263645-wupre5uj	255	78	-	-	HYPH
cord-263645-wupre5uj	255	79	Responsive	responsive	JJ
cord-263645-wupre5uj	255	80	Riboswitch	Riboswitch	NNP
cord-263645-wupre5uj	255	81	in	in	IN
cord-263645-wupre5uj	255	82	a	a	DT
cord-263645-wupre5uj	255	83	cellular	cellular	JJ
cord-263645-wupre5uj	255	84	context	context	NN
cord-263645-wupre5uj	255	85	Thiamine	thiamine	NN
cord-263645-wupre5uj	255	86	pyrophosphate	pyrophosphate	NN
cord-263645-wupre5uj	255	87	riboswitches	riboswitche	NNS
cord-263645-wupre5uj	255	88	are	be	VBP
cord-263645-wupre5uj	255	89	targets	target	NNS
cord-263645-wupre5uj	255	90	for	for	IN
cord-263645-wupre5uj	255	91	the	the	DT
cord-263645-wupre5uj	255	92	antimicrobial	antimicrobial	JJ
cord-263645-wupre5uj	255	93	compound	compound	NN
cord-263645-wupre5uj	256	1	Pyrithiamine	Pyrithiamine	NNP
cord-263645-wupre5uj	256	2	A	a	DT
cord-263645-wupre5uj	256	3	simple	simple	JJ
cord-263645-wupre5uj	256	4	ligand	ligand	NN
cord-263645-wupre5uj	256	5	that	that	WDT
cord-263645-wupre5uj	256	6	selectively	selectively	RB
cord-263645-wupre5uj	256	7	targets	target	VBZ
cord-263645-wupre5uj	256	8	CUG	CUG	NNP
cord-263645-wupre5uj	256	9	trinucleotide	trinucleotide	NNP
cord-263645-wupre5uj	256	10	repeats	repeat	VBZ
cord-263645-wupre5uj	256	11	and	and	CC
cord-263645-wupre5uj	256	12	inhibits	inhibit	VBZ
cord-263645-wupre5uj	256	13	MBNL	MBNL	NNP
cord-263645-wupre5uj	256	14	protein	protein	NN
cord-263645-wupre5uj	256	15	binding	bind	VBG
cord-263645-wupre5uj	256	16	Targeting	target	VBG
cord-263645-wupre5uj	256	17	toxic	toxic	JJ
cord-263645-wupre5uj	256	18	RNAs	rna	NNS
cord-263645-wupre5uj	256	19	that	that	WDT
cord-263645-wupre5uj	256	20	cause	cause	VBP
cord-263645-wupre5uj	256	21	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	256	22	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	256	23	Type	Type	NNP
cord-263645-wupre5uj	256	24	1	1	CD
cord-263645-wupre5uj	257	1	(	(	-LRB-
cord-263645-wupre5uj	257	2	DM1	dm1	NN
cord-263645-wupre5uj	257	3	)	)	-RRB-
cord-263645-wupre5uj	257	4	with	with	IN
cord-263645-wupre5uj	257	5	a	a	DT
cord-263645-wupre5uj	257	6	bisamidinium	bisamidinium	NN
cord-263645-wupre5uj	257	7	inhibitor	inhibitor	NN
cord-263645-wupre5uj	257	8	Specific	specific	JJ
cord-263645-wupre5uj	257	9	binding	binding	NN
cord-263645-wupre5uj	257	10	of	of	IN
cord-263645-wupre5uj	257	11	Hoechst	Hoechst	NNP
cord-263645-wupre5uj	257	12	33258	33258	CD
cord-263645-wupre5uj	257	13	to	to	IN
cord-263645-wupre5uj	257	14	site	site	NN
cord-263645-wupre5uj	257	15	1	1	CD
cord-263645-wupre5uj	257	16	thymidylate	thymidylate	NNP
cord-263645-wupre5uj	257	17	synthase	synthase	NN
cord-263645-wupre5uj	257	18	mRNA	mRNA	NNP
cord-263645-wupre5uj	257	19	Dynamic	dynamic	JJ
cord-263645-wupre5uj	257	20	combinatorial	combinatorial	JJ
cord-263645-wupre5uj	257	21	selection	selection	NN
cord-263645-wupre5uj	257	22	of	of	IN
cord-263645-wupre5uj	257	23	molecules	molecule	NNS
cord-263645-wupre5uj	257	24	capable	capable	JJ
cord-263645-wupre5uj	257	25	of	of	IN
cord-263645-wupre5uj	257	26	inhibiting	inhibit	VBG
cord-263645-wupre5uj	257	27	the	the	DT
cord-263645-wupre5uj	257	28	(	(	-LRB-
cord-263645-wupre5uj	257	29	CUG	CUG	NNP
cord-263645-wupre5uj	257	30	)	)	-RRB-
cord-263645-wupre5uj	258	1	repeat	repeat	VB
cord-263645-wupre5uj	258	2	RNA	RNA	NNP
cord-263645-wupre5uj	258	3	-	-	HYPH
cord-263645-wupre5uj	258	4	MBNL1	MBNL1	NNP
cord-263645-wupre5uj	258	5	interaction	interaction	NN
cord-263645-wupre5uj	258	6	in	in	IN
cord-263645-wupre5uj	258	7	vitro	vitro	FW
cord-263645-wupre5uj	258	8	:	:	:
cord-263645-wupre5uj	259	1	Discovery	discovery	NN
cord-263645-wupre5uj	259	2	of	of	IN
cord-263645-wupre5uj	259	3	lead	lead	JJ
cord-263645-wupre5uj	259	4	compounds	compound	NNS
cord-263645-wupre5uj	259	5	targeting	target	VBG
cord-263645-wupre5uj	259	6	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	259	7	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	259	8	(	(	-LRB-
cord-263645-wupre5uj	259	9	DM1	dm1	NN
cord-263645-wupre5uj	259	10	)	)	-RRB-
cord-263645-wupre5uj	259	11	From	from	IN
cord-263645-wupre5uj	259	12	dynamic	dynamic	JJ
cord-263645-wupre5uj	259	13	combinatorial	combinatorial	NN
cord-263645-wupre5uj	259	14	'	'	``
cord-263645-wupre5uj	259	15	hit	hit	NN
cord-263645-wupre5uj	259	16	'	'	''
cord-263645-wupre5uj	259	17	to	to	TO
cord-263645-wupre5uj	259	18	lead	lead	VB
cord-263645-wupre5uj	259	19	:	:	:
cord-263645-wupre5uj	259	20	In	in	IN
cord-263645-wupre5uj	259	21	vitro	vitro	FW
cord-263645-wupre5uj	259	22	and	and	CC
cord-263645-wupre5uj	259	23	in	in	IN
cord-263645-wupre5uj	259	24	vivo	vivo	NN
cord-263645-wupre5uj	259	25	activity	activity	NN
cord-263645-wupre5uj	259	26	of	of	IN
cord-263645-wupre5uj	259	27	compounds	compound	NNS
cord-263645-wupre5uj	259	28	targeting	target	VBG
cord-263645-wupre5uj	259	29	the	the	DT
cord-263645-wupre5uj	259	30	pathogenic	pathogenic	JJ
cord-263645-wupre5uj	259	31	RNAs	rna	NNS
cord-263645-wupre5uj	259	32	that	that	WDT
cord-263645-wupre5uj	259	33	cause	cause	VBP
cord-263645-wupre5uj	259	34	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	259	35	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	259	36	N	N	NNP
cord-263645-wupre5uj	259	37	-	-	HYPH
cord-263645-wupre5uj	259	38	Methylation	Methylation	NNP
cord-263645-wupre5uj	259	39	as	as	IN
cord-263645-wupre5uj	259	40	a	a	DT
cord-263645-wupre5uj	259	41	strategy	strategy	NN
cord-263645-wupre5uj	259	42	for	for	IN
cord-263645-wupre5uj	259	43	enhancing	enhance	VBG
cord-263645-wupre5uj	259	44	the	the	DT
cord-263645-wupre5uj	259	45	Affinity	affinity	NN
cord-263645-wupre5uj	259	46	and	and	CC
cord-263645-wupre5uj	259	47	selectivity	selectivity	NN
cord-263645-wupre5uj	259	48	of	of	IN
cord-263645-wupre5uj	259	49	RNA	rna	NN
cord-263645-wupre5uj	259	50	-	-	HYPH
cord-263645-wupre5uj	259	51	binding	bind	VBG
cord-263645-wupre5uj	259	52	peptides	peptide	NNS
cord-263645-wupre5uj	259	53	:	:	:
cord-263645-wupre5uj	259	54	application	application	NN
cord-263645-wupre5uj	259	55	to	to	IN
cord-263645-wupre5uj	259	56	the	the	DT
cord-263645-wupre5uj	259	57	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	260	1	Frameshift	frameshift	NN
cord-263645-wupre5uj	260	2	-	-	HYPH
cord-263645-wupre5uj	260	3	Stimulating	stimulate	VBG
cord-263645-wupre5uj	260	4	RNA	RNA	NNP
cord-263645-wupre5uj	261	1	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	261	2	Frameshift	Frameshift	NNP
cord-263645-wupre5uj	261	3	RNA	RNA	NNP
cord-263645-wupre5uj	261	4	-	-	HYPH
cord-263645-wupre5uj	261	5	targeted	target	VBN
cord-263645-wupre5uj	261	6	triazoles	triazole	NNS
cord-263645-wupre5uj	261	7	inhibit	inhibit	VBP
cord-263645-wupre5uj	261	8	propagation	propagation	NN
cord-263645-wupre5uj	261	9	of	of	IN
cord-263645-wupre5uj	261	10	replication	replication	NN
cord-263645-wupre5uj	261	11	-	-	HYPH
cord-263645-wupre5uj	261	12	competent	competent	JJ
cord-263645-wupre5uj	261	13	and	and	CC
cord-263645-wupre5uj	261	14	multi	multi	JJ
cord-263645-wupre5uj	261	15	-	-	JJ
cord-263645-wupre5uj	261	16	drug	drug	JJ
cord-263645-wupre5uj	261	17	-	-	HYPH
cord-263645-wupre5uj	261	18	resistant	resistant	JJ
cord-263645-wupre5uj	261	19	HIV	HIV	NNP
cord-263645-wupre5uj	261	20	in	in	IN
cord-263645-wupre5uj	261	21	human	human	JJ
cord-263645-wupre5uj	261	22	cells	cell	NNS
cord-263645-wupre5uj	261	23	High	high	JJ
cord-263645-wupre5uj	261	24	-	-	HYPH
cord-263645-wupre5uj	261	25	affinity	affinity	NN
cord-263645-wupre5uj	261	26	recognition	recognition	NN
cord-263645-wupre5uj	261	27	of	of	IN
cord-263645-wupre5uj	261	28	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	261	29	frameshift	frameshift	NN
cord-263645-wupre5uj	261	30	-	-	HYPH
cord-263645-wupre5uj	261	31	stimulating	stimulate	VBG
cord-263645-wupre5uj	261	32	RNA	RNA	NNP
cord-263645-wupre5uj	261	33	alters	alter	VBZ
cord-263645-wupre5uj	261	34	frameshifting	frameshifte	VBG
cord-263645-wupre5uj	261	35	in	in	IN
cord-263645-wupre5uj	261	36	vitro	vitro	FW
cord-263645-wupre5uj	261	37	and	and	CC
cord-263645-wupre5uj	261	38	interferes	interfere	VBZ
cord-263645-wupre5uj	261	39	with	with	IN
cord-263645-wupre5uj	261	40	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	261	41	infectivity	infectivity	NN
cord-263645-wupre5uj	262	1	The	the	DT
cord-263645-wupre5uj	262	2	promise	promise	NN
cord-263645-wupre5uj	262	3	and	and	CC
cord-263645-wupre5uj	262	4	peril	peril	NN
cord-263645-wupre5uj	262	5	of	of	IN
cord-263645-wupre5uj	262	6	chemical	chemical	NN
cord-263645-wupre5uj	262	7	probes	probe	NNS
cord-263645-wupre5uj	262	8	Target	Target	NNP
cord-263645-wupre5uj	262	9	identification	identification	NN
cord-263645-wupre5uj	262	10	and	and	CC
cord-263645-wupre5uj	262	11	mechanism	mechanism	NN
cord-263645-wupre5uj	262	12	of	of	IN
cord-263645-wupre5uj	262	13	action	action	NN
cord-263645-wupre5uj	262	14	in	in	IN
cord-263645-wupre5uj	262	15	chemical	chemical	JJ
cord-263645-wupre5uj	262	16	biology	biology	NN
cord-263645-wupre5uj	262	17	and	and	CC
cord-263645-wupre5uj	262	18	drug	drug	NN
cord-263645-wupre5uj	262	19	discovery	discovery	NN
cord-263645-wupre5uj	262	20	Design	Design	NNP
cord-263645-wupre5uj	262	21	and	and	CC
cord-263645-wupre5uj	262	22	antimicrobial	antimicrobial	JJ
cord-263645-wupre5uj	262	23	action	action	NN
cord-263645-wupre5uj	262	24	of	of	IN
cord-263645-wupre5uj	262	25	purine	purine	NNP
cord-263645-wupre5uj	262	26	analogues	analogue	NNS
cord-263645-wupre5uj	262	27	that	that	WDT
cord-263645-wupre5uj	262	28	bind	bind	VBP
cord-263645-wupre5uj	262	29	Guanine	Guanine	NNP
cord-263645-wupre5uj	262	30	riboswitches	riboswitche	NNS
cord-263645-wupre5uj	262	31	Dual	dual	JJ
cord-263645-wupre5uj	262	32	-	-	HYPH
cord-263645-wupre5uj	262	33	targeting	target	VBG
cord-263645-wupre5uj	262	34	small	small	JJ
cord-263645-wupre5uj	262	35	-	-	HYPH
cord-263645-wupre5uj	262	36	molecule	molecule	NN
cord-263645-wupre5uj	262	37	inhibitors	inhibitor	NNS
cord-263645-wupre5uj	262	38	of	of	IN
cord-263645-wupre5uj	262	39	the	the	DT
cord-263645-wupre5uj	262	40	Staphylococcus	Staphylococcus	NNP
cord-263645-wupre5uj	262	41	aureus	aureus	NN
cord-263645-wupre5uj	262	42	FMN	fmn	NN
cord-263645-wupre5uj	262	43	riboswitch	riboswitch	NN
cord-263645-wupre5uj	262	44	disrupt	disrupt	VBP
cord-263645-wupre5uj	262	45	riboflavin	riboflavin	NN
cord-263645-wupre5uj	262	46	homeostasis	homeostasis	NN
cord-263645-wupre5uj	262	47	in	in	IN
cord-263645-wupre5uj	262	48	an	an	DT
cord-263645-wupre5uj	262	49	infectious	infectious	JJ
cord-263645-wupre5uj	262	50	setting	setting	NN
cord-263645-wupre5uj	262	51	Conformational	Conformational	NNP
cord-263645-wupre5uj	262	52	inhibition	inhibition	NN
cord-263645-wupre5uj	262	53	of	of	IN
cord-263645-wupre5uj	262	54	the	the	DT
cord-263645-wupre5uj	262	55	hepatitis	hepatitis	NN
cord-263645-wupre5uj	262	56	C	C	NNP
cord-263645-wupre5uj	262	57	virus	virus	NN
cord-263645-wupre5uj	262	58	internal	internal	JJ
cord-263645-wupre5uj	262	59	ribosome	ribosome	NN
cord-263645-wupre5uj	262	60	entry	entry	NN
cord-263645-wupre5uj	262	61	site	site	NN
cord-263645-wupre5uj	262	62	RNA	RNA	NNP
cord-263645-wupre5uj	262	63	Inhibition	Inhibition	NNP
cord-263645-wupre5uj	262	64	of	of	IN
cord-263645-wupre5uj	262	65	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	262	66	Tat	Tat	NNP
cord-263645-wupre5uj	262	67	-	-	HYPH
cord-263645-wupre5uj	262	68	TAR	tar	NN
cord-263645-wupre5uj	262	69	interaction	interaction	NN
cord-263645-wupre5uj	262	70	by	by	IN
cord-263645-wupre5uj	262	71	diphenylfuran	diphenylfuran	JJ
cord-263645-wupre5uj	262	72	derivatives	derivative	NNS
cord-263645-wupre5uj	262	73	:	:	:
cord-263645-wupre5uj	262	74	effects	effect	NNS
cord-263645-wupre5uj	262	75	of	of	IN
cord-263645-wupre5uj	262	76	the	the	DT
cord-263645-wupre5uj	262	77	terminal	terminal	JJ
cord-263645-wupre5uj	262	78	basic	basic	JJ
cord-263645-wupre5uj	262	79	side	side	NN
cord-263645-wupre5uj	262	80	chains	chain	NNS
cord-263645-wupre5uj	262	81	Small	small	JJ
cord-263645-wupre5uj	262	82	molecule	molecule	NN
cord-263645-wupre5uj	262	83	inhibition	inhibition	NN
cord-263645-wupre5uj	262	84	of	of	IN
cord-263645-wupre5uj	262	85	miR-544	miR-544	NNP
cord-263645-wupre5uj	262	86	biogenesis	biogenesis	NN
cord-263645-wupre5uj	262	87	disrupts	disrupt	VBZ
cord-263645-wupre5uj	262	88	adaptive	adaptive	JJ
cord-263645-wupre5uj	262	89	responses	response	NNS
cord-263645-wupre5uj	262	90	to	to	IN
cord-263645-wupre5uj	262	91	hypoxia	hypoxia	NN
cord-263645-wupre5uj	262	92	by	by	IN
cord-263645-wupre5uj	262	93	modulating	modulate	VBG
cord-263645-wupre5uj	262	94	ATM	ATM	NNP
cord-263645-wupre5uj	262	95	-	-	HYPH
cord-263645-wupre5uj	262	96	mTOR	mtor	NN
cord-263645-wupre5uj	262	97	signaling	signal	VBG
cord-263645-wupre5uj	262	98	Design	Design	NNP
cord-263645-wupre5uj	262	99	of	of	IN
cord-263645-wupre5uj	262	100	a	a	DT
cord-263645-wupre5uj	262	101	bioactive	bioactive	JJ
cord-263645-wupre5uj	262	102	small	small	JJ
cord-263645-wupre5uj	262	103	molecule	molecule	NN
cord-263645-wupre5uj	262	104	that	that	WDT
cord-263645-wupre5uj	262	105	targets	target	VBZ
cord-263645-wupre5uj	262	106	the	the	DT
cord-263645-wupre5uj	262	107	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	262	108	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	262	109	Type	Type	NNP
cord-263645-wupre5uj	262	110	1	1	CD
cord-263645-wupre5uj	262	111	RNA	RNA	NNP
cord-263645-wupre5uj	262	112	via	via	IN
cord-263645-wupre5uj	262	113	an	an	DT
cord-263645-wupre5uj	262	114	RNA	RNA	NNP
cord-263645-wupre5uj	262	115	motif	motif	NN
cord-263645-wupre5uj	262	116	-	-	HYPH
cord-263645-wupre5uj	262	117	ligand	ligand	NN
cord-263645-wupre5uj	262	118	database	database	NN
cord-263645-wupre5uj	262	119	and	and	CC
cord-263645-wupre5uj	262	120	chemical	chemical	NN
cord-263645-wupre5uj	262	121	similarity	similarity	NN
cord-263645-wupre5uj	262	122	searching	search	VBG
cord-263645-wupre5uj	262	123	Induction	induction	NN
cord-263645-wupre5uj	262	124	and	and	CC
cord-263645-wupre5uj	262	125	reversal	reversal	NN
cord-263645-wupre5uj	262	126	of	of	IN
cord-263645-wupre5uj	262	127	Myotonic	Myotonic	NNP
cord-263645-wupre5uj	262	128	Dystrophy	Dystrophy	NNP
cord-263645-wupre5uj	262	129	Type	Type	NNP
cord-263645-wupre5uj	262	130	1	1	CD
cord-263645-wupre5uj	262	131	pre	pre	JJ
cord-263645-wupre5uj	262	132	-	-	JJ
cord-263645-wupre5uj	262	133	mRNA	mrna	JJ
cord-263645-wupre5uj	262	134	splicing	splicing	NN
cord-263645-wupre5uj	262	135	defects	defect	NNS
cord-263645-wupre5uj	262	136	by	by	IN
cord-263645-wupre5uj	262	137	small	small	JJ
cord-263645-wupre5uj	262	138	molecules	molecule	NNS
cord-263645-wupre5uj	262	139	Targeting	target	VBG
cord-263645-wupre5uj	262	140	the	the	DT
cord-263645-wupre5uj	262	141	r(CGG	r(CGG	NNP
cord-263645-wupre5uj	262	142	)	)	-RRB-
cord-263645-wupre5uj	262	143	repeats	repeat	VBZ
cord-263645-wupre5uj	262	144	that	that	IN
cord-263645-wupre5uj	262	145	cause	cause	VBP
cord-263645-wupre5uj	262	146	FXTAS	FXTAS	NNP
cord-263645-wupre5uj	262	147	with	with	IN
cord-263645-wupre5uj	262	148	modularly	modularly	RB
cord-263645-wupre5uj	262	149	assembled	assemble	VBN
cord-263645-wupre5uj	262	150	small	small	JJ
cord-263645-wupre5uj	262	151	molecules	molecule	NNS
cord-263645-wupre5uj	262	152	and	and	CC
cord-263645-wupre5uj	262	153	oligonucleotides	oligonucleotide	NNS
cord-263645-wupre5uj	262	154	Small	small	JJ
cord-263645-wupre5uj	262	155	molecule	molecule	NN
cord-263645-wupre5uj	262	156	recognition	recognition	NN
cord-263645-wupre5uj	262	157	and	and	CC
cord-263645-wupre5uj	262	158	tools	tool	NNS
cord-263645-wupre5uj	262	159	to	to	TO
cord-263645-wupre5uj	262	160	study	study	VB
cord-263645-wupre5uj	262	161	modulation	modulation	NN
cord-263645-wupre5uj	262	162	of	of	IN
cord-263645-wupre5uj	262	163	r(CGG)(exp	r(cgg)(exp	NN
cord-263645-wupre5uj	262	164	)	)	-RRB-
cord-263645-wupre5uj	262	165	in	in	IN
cord-263645-wupre5uj	262	166	Fragile	Fragile	NNP
cord-263645-wupre5uj	262	167	X	X	NNP
cord-263645-wupre5uj	262	168	-	-	NNP
cord-263645-wupre5uj	262	169	Associated	associated	JJ
cord-263645-wupre5uj	262	170	Tremor	Tremor	NNP
cord-263645-wupre5uj	262	171	Ataxia	Ataxia	NNP
cord-263645-wupre5uj	262	172	Syndrome	Syndrome	NNP
cord-263645-wupre5uj	263	1	Precise	precise	JJ
cord-263645-wupre5uj	263	2	small	small	JJ
cord-263645-wupre5uj	263	3	-	-	HYPH
cord-263645-wupre5uj	263	4	molecule	molecule	NN
cord-263645-wupre5uj	263	5	recognition	recognition	NN
cord-263645-wupre5uj	263	6	of	of	IN
cord-263645-wupre5uj	263	7	a	a	DT
cord-263645-wupre5uj	263	8	toxic	toxic	JJ
cord-263645-wupre5uj	263	9	CUG	CUG	NNP
cord-263645-wupre5uj	263	10	RNA	RNA	NNP
cord-263645-wupre5uj	263	11	repeat	repeat	NN
cord-263645-wupre5uj	263	12	expansion	expansion	NN
cord-263645-wupre5uj	263	13	Approaches	approach	NNS
cord-263645-wupre5uj	263	14	to	to	TO
cord-263645-wupre5uj	263	15	validate	validate	VB
cord-263645-wupre5uj	263	16	and	and	CC
cord-263645-wupre5uj	263	17	manipulate	manipulate	VB
cord-263645-wupre5uj	263	18	RNA	RNA	NNP
cord-263645-wupre5uj	263	19	targets	target	NNS
cord-263645-wupre5uj	263	20	with	with	IN
cord-263645-wupre5uj	263	21	small	small	JJ
cord-263645-wupre5uj	263	22	molecules	molecule	NNS
cord-263645-wupre5uj	263	23	in	in	IN
cord-263645-wupre5uj	263	24	cells	cell	NNS
cord-263645-wupre5uj	263	25	Discovery	Discovery	NNP
cord-263645-wupre5uj	263	26	of	of	IN
cord-263645-wupre5uj	263	27	a	a	DT
cord-263645-wupre5uj	263	28	biomarker	biomarker	NN
cord-263645-wupre5uj	263	29	and	and	CC
cord-263645-wupre5uj	263	30	lead	lead	VB
cord-263645-wupre5uj	263	31	small	small	JJ
cord-263645-wupre5uj	263	32	molecules	molecule	NNS
cord-263645-wupre5uj	263	33	to	to	TO
cord-263645-wupre5uj	263	34	target	target	VB
cord-263645-wupre5uj	263	35	r(GGGGCC)-associated	r(GGGGCC)-associated	NNP
cord-263645-wupre5uj	263	36	defects	defect	NNS
cord-263645-wupre5uj	263	37	in	in	IN
cord-263645-wupre5uj	263	38	c9FTD	c9FTD	NNP
cord-263645-wupre5uj	263	39	/	/	SYM
cord-263645-wupre5uj	263	40	ALS	ALS	NNP
cord-263645-wupre5uj	263	41	Lomofungin	Lomofungin	NNP
cord-263645-wupre5uj	263	42	and	and	CC
cord-263645-wupre5uj	263	43	dilomofungin	dilomofungin	NNP
cord-263645-wupre5uj	263	44	:	:	:
cord-263645-wupre5uj	264	1	Inhibitors	Inhibitors	NNP
cord-263645-wupre5uj	264	2	of	of	IN
cord-263645-wupre5uj	264	3	MBNL1-CUG	MBNL1-CUG	NNP
cord-263645-wupre5uj	264	4	RNA	RNA	NNP
cord-263645-wupre5uj	264	5	binding	bind	VBG
cord-263645-wupre5uj	264	6	with	with	IN
cord-263645-wupre5uj	264	7	distinct	distinct	JJ
cord-263645-wupre5uj	264	8	cellular	cellular	JJ
cord-263645-wupre5uj	264	9	effects	effect	NNS
cord-263645-wupre5uj	264	10	Non	non	NN
cord-263645-wupre5uj	264	11	-	-	JJ
cord-263645-wupre5uj	264	12	coding	code	VBG
cord-263645-wupre5uj	264	13	RNAs	rna	NNS
cord-263645-wupre5uj	264	14	as	as	IN
cord-263645-wupre5uj	264	15	antibiotic	antibiotic	JJ
cord-263645-wupre5uj	264	16	targets	target	NNS
cord-263645-wupre5uj	264	17	Small	small	JJ
cord-263645-wupre5uj	264	18	regulatory	regulatory	JJ
cord-263645-wupre5uj	264	19	RNAs	rna	NNS
cord-263645-wupre5uj	264	20	in	in	IN
cord-263645-wupre5uj	264	21	Archaea	Archaea	NNP
cord-263645-wupre5uj	264	22	Small	small	JJ
cord-263645-wupre5uj	264	23	RNAs	rna	NNS
cord-263645-wupre5uj	264	24	in	in	IN
cord-263645-wupre5uj	264	25	bacteria	bacteria	NNS
cord-263645-wupre5uj	264	26	and	and	CC
cord-263645-wupre5uj	264	27	archaea	archaea	NNS
cord-263645-wupre5uj	264	28	:	:	:
cord-263645-wupre5uj	264	29	who	who	WP
cord-263645-wupre5uj	264	30	they	-PRON-	PRP
cord-263645-wupre5uj	264	31	are	be	VBP
cord-263645-wupre5uj	264	32	,	,	,
cord-263645-wupre5uj	264	33	what	what	WP
cord-263645-wupre5uj	264	34	they	-PRON-	PRP
cord-263645-wupre5uj	264	35	do	do	VBP
cord-263645-wupre5uj	264	36	,	,	,
cord-263645-wupre5uj	264	37	and	and	CC
cord-263645-wupre5uj	264	38	how	how	WRB
cord-263645-wupre5uj	264	39	they	-PRON-	PRP
cord-263645-wupre5uj	264	40	do	do	VBP
cord-263645-wupre5uj	264	41	it	-PRON-	PRP
cord-263645-wupre5uj	264	42	RNA	RNA	NNP
cord-263645-wupre5uj	264	43	structures	structure	NNS
cord-263645-wupre5uj	264	44	as	as	IN
cord-263645-wupre5uj	264	45	mediators	mediator	NNS
cord-263645-wupre5uj	264	46	of	of	IN
cord-263645-wupre5uj	264	47	neurological	neurological	JJ
cord-263645-wupre5uj	264	48	diseases	disease	NNS
cord-263645-wupre5uj	264	49	and	and	CC
cord-263645-wupre5uj	264	50	as	as	IN
cord-263645-wupre5uj	264	51	drug	drug	NN
cord-263645-wupre5uj	264	52	targets	target	VBZ
cord-263645-wupre5uj	264	53	Antibacterial	antibacterial	JJ
cord-263645-wupre5uj	264	54	drug	drug	NN
cord-263645-wupre5uj	264	55	discovery	discovery	NN
cord-263645-wupre5uj	264	56	in	in	IN
cord-263645-wupre5uj	264	57	the	the	DT
cord-263645-wupre5uj	264	58	resistance	resistance	NN
cord-263645-wupre5uj	264	59	era	era	NN
cord-263645-wupre5uj	264	60	Fungal	Fungal	NNP
cord-263645-wupre5uj	264	61	RNA	RNA	NNP
cord-263645-wupre5uj	264	62	Biology	Biology	NNP
cord-263645-wupre5uj	265	1	The	the	DT
cord-263645-wupre5uj	265	2	antifungal	antifungal	JJ
cord-263645-wupre5uj	265	3	pipeline	pipeline	NN
cord-263645-wupre5uj	265	4	:	:	:
cord-263645-wupre5uj	265	5	a	a	DT
cord-263645-wupre5uj	265	6	reality	reality	NN
cord-263645-wupre5uj	265	7	check	check	NN
cord-263645-wupre5uj	265	8	Non	Non	NNP
cord-263645-wupre5uj	265	9	-	-	NN
cord-263645-wupre5uj	265	10	coding	code	VBG
cord-263645-wupre5uj	265	11	RNA	rna	NN
cord-263645-wupre5uj	265	12	:	:	:
cord-263645-wupre5uj	266	1	What	what	WP
cord-263645-wupre5uj	266	2	is	be	VBZ
cord-263645-wupre5uj	266	3	functional	functional	JJ
cord-263645-wupre5uj	266	4	and	and	CC
cord-263645-wupre5uj	266	5	what	what	WP
cord-263645-wupre5uj	266	6	is	be	VBZ
cord-263645-wupre5uj	266	7	junk	junk	NN
cord-263645-wupre5uj	266	8	?	?	.
cord-263645-wupre5uj	267	1	Front	Front	NNP
cord-263645-wupre5uj	267	2	Specificity	Specificity	NNP
cord-263645-wupre5uj	267	3	and	and	CC
cord-263645-wupre5uj	267	4	nonspecificity	nonspecificity	NN
cord-263645-wupre5uj	267	5	in	in	IN
cord-263645-wupre5uj	267	6	RNA	rna	NN
cord-263645-wupre5uj	267	7	-	-	HYPH
cord-263645-wupre5uj	267	8	protein	protein	NN
cord-263645-wupre5uj	267	9	interactions	interaction	NNS
cord-263645-wupre5uj	268	1	An	an	DT
cord-263645-wupre5uj	268	2	abundance	abundance	NN
cord-263645-wupre5uj	268	3	of	of	IN
cord-263645-wupre5uj	268	4	ubiquitously	ubiquitously	RB
cord-263645-wupre5uj	268	5	expressed	express	VBN
cord-263645-wupre5uj	268	6	genes	gene	NNS
cord-263645-wupre5uj	268	7	revealed	reveal	VBN
cord-263645-wupre5uj	268	8	by	by	IN
cord-263645-wupre5uj	268	9	tissue	tissue	NN
cord-263645-wupre5uj	268	10	transcriptome	transcriptome	NN
cord-263645-wupre5uj	268	11	sequence	sequence	NN
cord-263645-wupre5uj	268	12	data	data	NN
cord-263645-wupre5uj	268	13	MicroRNAs	MicroRNAs	NNP
cord-263645-wupre5uj	268	14	and	and	CC
cord-263645-wupre5uj	268	15	other	other	JJ
cord-263645-wupre5uj	268	16	non	non	JJ
cord-263645-wupre5uj	268	17	-	-	JJ
cord-263645-wupre5uj	268	18	coding	coding	JJ
cord-263645-wupre5uj	268	19	RNAs	rna	NNS
cord-263645-wupre5uj	268	20	as	as	IN
cord-263645-wupre5uj	268	21	targets	target	NNS
cord-263645-wupre5uj	268	22	for	for	IN
cord-263645-wupre5uj	268	23	anticancer	anticancer	JJ
cord-263645-wupre5uj	268	24	drug	drug	NN
cord-263645-wupre5uj	268	25	development	development	NN
cord-263645-wupre5uj	268	26	Enhancements	enhancement	NNS
cord-263645-wupre5uj	268	27	of	of	IN
cord-263645-wupre5uj	268	28	screening	screen	VBG
cord-263645-wupre5uj	268	29	collections	collection	NNS
cord-263645-wupre5uj	268	30	to	to	TO
cord-263645-wupre5uj	268	31	address	address	VB
cord-263645-wupre5uj	268	32	areas	area	NNS
cord-263645-wupre5uj	268	33	of	of	IN
cord-263645-wupre5uj	268	34	unmet	unmet	JJ
cord-263645-wupre5uj	268	35	medical	medical	JJ
cord-263645-wupre5uj	268	36	need	need	NN
cord-263645-wupre5uj	268	37	:	:	:
cord-263645-wupre5uj	268	38	an	an	DT
cord-263645-wupre5uj	268	39	industry	industry	NN
cord-263645-wupre5uj	268	40	perspective	perspective	NN
cord-263645-wupre5uj	269	1	The	the	DT
cord-263645-wupre5uj	269	2	re	re	NN
cord-263645-wupre5uj	269	3	-	-	NN
cord-263645-wupre5uj	269	4	emergence	emergence	NN
cord-263645-wupre5uj	269	5	of	of	IN
cord-263645-wupre5uj	269	6	natural	natural	JJ
cord-263645-wupre5uj	269	7	products	product	NNS
cord-263645-wupre5uj	269	8	for	for	IN
cord-263645-wupre5uj	269	9	drug	drug	NN
cord-263645-wupre5uj	269	10	discovery	discovery	NN
cord-263645-wupre5uj	269	11	in	in	IN
cord-263645-wupre5uj	269	12	the	the	DT
cord-263645-wupre5uj	269	13	genomics	genomic	NNS
cord-263645-wupre5uj	269	14	era	era	NN
cord-263645-wupre5uj	269	15	Development	development	NN
cord-263645-wupre5uj	269	16	and	and	CC
cord-263645-wupre5uj	269	17	implementation	implementation	NN
cord-263645-wupre5uj	269	18	of	of	IN
cord-263645-wupre5uj	269	19	an	an	DT
cord-263645-wupre5uj	269	20	HTS	HTS	NNP
cord-263645-wupre5uj	269	21	-	-	HYPH
cord-263645-wupre5uj	269	22	compatible	compatible	JJ
cord-263645-wupre5uj	269	23	assay	assay	NN
cord-263645-wupre5uj	269	24	for	for	IN
cord-263645-wupre5uj	269	25	the	the	DT
cord-263645-wupre5uj	269	26	discovery	discovery	NN
cord-263645-wupre5uj	269	27	of	of	IN
cord-263645-wupre5uj	269	28	selective	selective	JJ
cord-263645-wupre5uj	269	29	small	small	JJ
cord-263645-wupre5uj	269	30	-	-	HYPH
cord-263645-wupre5uj	269	31	molecule	molecule	NN
cord-263645-wupre5uj	269	32	ligands	ligand	NNS
cord-263645-wupre5uj	269	33	for	for	IN
cord-263645-wupre5uj	269	34	pre	pre	JJ
cord-263645-wupre5uj	269	35	-	-	JJ
cord-263645-wupre5uj	269	36	microRNAs	micrornas	JJ
cord-263645-wupre5uj	269	37	RNA	RNA	NNP
cord-263645-wupre5uj	269	38	fluorescence	fluorescence	NN
cord-263645-wupre5uj	269	39	in	in	IN
cord-263645-wupre5uj	269	40	situ	situ	NN
cord-263645-wupre5uj	269	41	hybridization	hybridization	NN
cord-263645-wupre5uj	269	42	for	for	IN
cord-263645-wupre5uj	269	43	high	high	JJ
cord-263645-wupre5uj	269	44	-	-	HYPH
cord-263645-wupre5uj	269	45	content	content	NN
cord-263645-wupre5uj	269	46	screening	screening	NN
cord-263645-wupre5uj	269	47	Progress	Progress	NNP
cord-263645-wupre5uj	269	48	and	and	CC
cord-263645-wupre5uj	269	49	challenges	challenge	NNS
cord-263645-wupre5uj	269	50	for	for	IN
cord-263645-wupre5uj	269	51	chemical	chemical	NN
cord-263645-wupre5uj	269	52	probing	probing	NN
cord-263645-wupre5uj	269	53	of	of	IN
cord-263645-wupre5uj	269	54	RNA	RNA	NNP
cord-263645-wupre5uj	269	55	structure	structure	NN
cord-263645-wupre5uj	269	56	inside	inside	IN
cord-263645-wupre5uj	269	57	living	living	NN
cord-263645-wupre5uj	269	58	cells	cell	NNS
cord-263645-wupre5uj	269	59	Detection	Detection	NNP
cord-263645-wupre5uj	269	60	of	of	IN
cord-263645-wupre5uj	269	61	RNA	rna	NN
cord-263645-wupre5uj	269	62	-	-	HYPH
cord-263645-wupre5uj	269	63	protein	protein	NN
cord-263645-wupre5uj	269	64	interactions	interaction	NNS
cord-263645-wupre5uj	269	65	in	in	IN
cord-263645-wupre5uj	269	66	living	live	VBG
cord-263645-wupre5uj	269	67	cells	cell	NNS
cord-263645-wupre5uj	269	68	with	with	IN
cord-263645-wupre5uj	269	69	SHAPE	shape	NN
cord-263645-wupre5uj	270	1	Photoaffinity	photoaffinity	NN
cord-263645-wupre5uj	270	2	labeling	labeling	NN
cord-263645-wupre5uj	270	3	in	in	IN
cord-263645-wupre5uj	270	4	target	target	NN
cord-263645-wupre5uj	270	5	-	-	HYPH
cord-263645-wupre5uj	270	6	and	and	CC
cord-263645-wupre5uj	270	7	binding	binding	JJ
cord-263645-wupre5uj	270	8	-	-	HYPH
cord-263645-wupre5uj	270	9	site	site	NN
cord-263645-wupre5uj	270	10	identification	identification	NN
cord-263645-wupre5uj	270	11	Using	use	VBG
cord-263645-wupre5uj	270	12	transcriptome	transcriptome	NN
cord-263645-wupre5uj	270	13	sequencing	sequencing	NN
cord-263645-wupre5uj	270	14	to	to	TO
cord-263645-wupre5uj	270	15	identify	identify	VB
cord-263645-wupre5uj	270	16	mechanisms	mechanism	NNS
cord-263645-wupre5uj	270	17	of	of	IN
cord-263645-wupre5uj	270	18	drug	drug	NN
cord-263645-wupre5uj	270	19	action	action	NN
cord-263645-wupre5uj	270	20	and	and	CC
cord-263645-wupre5uj	270	21	resistance	resistance	NN
cord-263645-wupre5uj	270	22	Emerging	Emerging	NNP
cord-263645-wupre5uj	270	23	classes	class	NNS
cord-263645-wupre5uj	270	24	of	of	IN
cord-263645-wupre5uj	270	25	protein	protein	NN
cord-263645-wupre5uj	270	26	-	-	HYPH
cord-263645-wupre5uj	270	27	protein	protein	NN
cord-263645-wupre5uj	270	28	interaction	interaction	NN
cord-263645-wupre5uj	270	29	inhibitors	inhibitor	NNS
cord-263645-wupre5uj	270	30	and	and	CC
cord-263645-wupre5uj	270	31	new	new	JJ
cord-263645-wupre5uj	270	32	tools	tool	NNS
cord-263645-wupre5uj	270	33	for	for	IN
cord-263645-wupre5uj	270	34	their	-PRON-	PRP$
cord-263645-wupre5uj	270	35	development	development	NN
cord-263645-wupre5uj	270	36	Small	small	JJ
cord-263645-wupre5uj	270	37	molecules	molecule	NNS
cord-263645-wupre5uj	270	38	,	,	,
cord-263645-wupre5uj	270	39	big	big	JJ
cord-263645-wupre5uj	270	40	targets	target	NNS
cord-263645-wupre5uj	271	1	:	:	:
cord-263645-wupre5uj	271	2	drug	drug	NN
cord-263645-wupre5uj	271	3	discovery	discovery	NN
cord-263645-wupre5uj	271	4	faces	face	VBZ
cord-263645-wupre5uj	271	5	the	the	DT
cord-263645-wupre5uj	271	6	protein	protein	NN
cord-263645-wupre5uj	271	7	-	-	HYPH
cord-263645-wupre5uj	271	8	protein	protein	NN
cord-263645-wupre5uj	271	9	interaction	interaction	NN
cord-263645-wupre5uj	271	10	challenge	challenge	NN
cord-263645-wupre5uj	272	1	A	a	DT
cord-263645-wupre5uj	272	2	small	small	JJ
cord-263645-wupre5uj	272	3	molecule	molecule	NN
cord-263645-wupre5uj	272	4	that	that	WDT
cord-263645-wupre5uj	272	5	targets	target	VBZ
cord-263645-wupre5uj	272	6	r(CGG)(exp	r(CGG)(exp	NNP
cord-263645-wupre5uj	272	7	)	)	-RRB-
cord-263645-wupre5uj	272	8	and	and	CC
cord-263645-wupre5uj	272	9	improves	improve	VBZ
cord-263645-wupre5uj	272	10	defects	defect	NNS
cord-263645-wupre5uj	272	11	in	in	IN
cord-263645-wupre5uj	272	12	fragile	fragile	JJ
cord-263645-wupre5uj	272	13	X	x	NN
cord-263645-wupre5uj	272	14	-	-	JJ
cord-263645-wupre5uj	272	15	associated	associate	VBN
cord-263645-wupre5uj	272	16	tremor	tremor	NN
cord-263645-wupre5uj	272	17	ataxia	ataxia	NN
cord-263645-wupre5uj	272	18	syndrome	syndrome	NN
cord-263645-wupre5uj	272	19	Development	Development	NNP
cord-263645-wupre5uj	272	20	of	of	IN
cord-263645-wupre5uj	272	21	pharmacophore	pharmacophore	NN
cord-263645-wupre5uj	272	22	models	model	NNS
cord-263645-wupre5uj	272	23	for	for	IN
cord-263645-wupre5uj	272	24	small	small	JJ
cord-263645-wupre5uj	272	25	molecules	molecule	NNS
cord-263645-wupre5uj	272	26	targeting	target	VBG
cord-263645-wupre5uj	272	27	RNA	rna	NN
cord-263645-wupre5uj	272	28	:	:	:
cord-263645-wupre5uj	273	1	application	application	NN
cord-263645-wupre5uj	273	2	to	to	IN
cord-263645-wupre5uj	273	3	the	the	DT
cord-263645-wupre5uj	273	4	RNA	RNA	NNP
cord-263645-wupre5uj	273	5	repeat	repeat	NN
cord-263645-wupre5uj	273	6	expansion	expansion	NN
cord-263645-wupre5uj	273	7	in	in	IN
cord-263645-wupre5uj	273	8	myotonic	myotonic	JJ
cord-263645-wupre5uj	273	9	dystrophy	dystrophy	NN
cord-263645-wupre5uj	273	10	type	type	NN
cord-263645-wupre5uj	273	11	1	1	CD
cord-263645-wupre5uj	273	12	Identification	identification	NN
cord-263645-wupre5uj	273	13	of	of	IN
cord-263645-wupre5uj	273	14	biologically	biologically	RB
cord-263645-wupre5uj	273	15	active	active	JJ
cord-263645-wupre5uj	273	16	,	,	,
cord-263645-wupre5uj	273	17	HIV	HIV	NNP
cord-263645-wupre5uj	273	18	TAR	TAR	NNP
cord-263645-wupre5uj	273	19	RNA	RNA	NNP
cord-263645-wupre5uj	273	20	-	-	HYPH
cord-263645-wupre5uj	273	21	binding	bind	VBG
cord-263645-wupre5uj	273	22	small	small	JJ
cord-263645-wupre5uj	273	23	molecules	molecule	NNS
cord-263645-wupre5uj	273	24	using	use	VBG
cord-263645-wupre5uj	273	25	small	small	JJ
cord-263645-wupre5uj	273	26	molecule	molecule	NN
cord-263645-wupre5uj	273	27	microarrays	microarray	NNS
cord-263645-wupre5uj	273	28	Importance	importance	NN
cord-263645-wupre5uj	273	29	of	of	IN
cord-263645-wupre5uj	273	30	ribosomal	ribosomal	JJ
cord-263645-wupre5uj	273	31	frameshifting	frameshifte	VBG
cord-263645-wupre5uj	273	32	for	for	IN
cord-263645-wupre5uj	273	33	Human	Human	NNP
cord-263645-wupre5uj	273	34	Immunodeficiency	Immunodeficiency	NNP
cord-263645-wupre5uj	273	35	Virus	Virus	NNP
cord-263645-wupre5uj	273	36	Type	Type	NNP
cord-263645-wupre5uj	273	37	1	1	CD
cord-263645-wupre5uj	273	38	particle	particle	NN
cord-263645-wupre5uj	273	39	assembly	assembly	NN
cord-263645-wupre5uj	273	40	and	and	CC
cord-263645-wupre5uj	273	41	replication	replication	NN
cord-263645-wupre5uj	273	42	Bioavailable	Bioavailable	NNP
cord-263645-wupre5uj	273	43	inhibitors	inhibitor	NNS
cord-263645-wupre5uj	273	44	of	of	IN
cord-263645-wupre5uj	273	45	HIV-1	HIV-1	NNP
cord-263645-wupre5uj	273	46	RNA	RNA	NNP
cord-263645-wupre5uj	273	47	biogenesis	biogenesis	NN
cord-263645-wupre5uj	273	48	identified	identify	VBN
cord-263645-wupre5uj	273	49	through	through	IN
cord-263645-wupre5uj	273	50	a	a	DT
cord-263645-wupre5uj	273	51	Rev	Rev	NNP
cord-263645-wupre5uj	273	52	-	-	HYPH
cord-263645-wupre5uj	273	53	based	base	VBN
cord-263645-wupre5uj	273	54	screen	screen	NN
cord-263645-wupre5uj	273	55	A	a	DT
cord-263645-wupre5uj	273	56	modular	modular	JJ
cord-263645-wupre5uj	273	57	approach	approach	NN
cord-263645-wupre5uj	273	58	to	to	IN
cord-263645-wupre5uj	273	59	synthetic	synthetic	JJ
cord-263645-wupre5uj	273	60	RNA	RNA	NNP
cord-263645-wupre5uj	273	61	binders	binder	NNS
cord-263645-wupre5uj	273	62	of	of	IN
cord-263645-wupre5uj	273	63	the	the	DT
cord-263645-wupre5uj	273	64	hepatitis	hepatitis	NN
cord-263645-wupre5uj	273	65	C	C	NNP
cord-263645-wupre5uj	273	66	virus	virus	NN
cord-263645-wupre5uj	273	67	internal	internal	JJ
cord-263645-wupre5uj	273	68	ribosome	ribosome	NN
cord-263645-wupre5uj	273	69	entry	entry	NN
cord-263645-wupre5uj	273	70	site	site	NN
cord-263645-wupre5uj	273	71	Artificial	artificial	JJ
cord-263645-wupre5uj	273	72	nucleobase	nucleobase	NN
cord-263645-wupre5uj	273	73	-	-	HYPH
cord-263645-wupre5uj	273	74	amino	amino	NN
cord-263645-wupre5uj	273	75	acid	acid	NN
cord-263645-wupre5uj	273	76	conjugates	conjugate	NNS
cord-263645-wupre5uj	273	77	:	:	:
cord-263645-wupre5uj	273	78	a	a	DT
cord-263645-wupre5uj	273	79	new	new	JJ
cord-263645-wupre5uj	273	80	class	class	NN
cord-263645-wupre5uj	273	81	of	of	IN
cord-263645-wupre5uj	273	82	TAR	TAR	NNP
cord-263645-wupre5uj	273	83	RNA	RNA	NNP
cord-263645-wupre5uj	273	84	binding	bind	VBG
cord-263645-wupre5uj	273	85	agents	agent	NNS
cord-263645-wupre5uj	274	1	We	-PRON-	PRP
cord-263645-wupre5uj	274	2	thank	thank	VBP
cord-263645-wupre5uj	274	3	the	the	DT
cord-263645-wupre5uj	274	4	members	member	NNS
cord-263645-wupre5uj	274	5	of	of	IN
cord-263645-wupre5uj	274	6	the	the	DT
cord-263645-wupre5uj	274	7	Hargrove	Hargrove	NNP
cord-263645-wupre5uj	274	8	lab	lab	NN
cord-263645-wupre5uj	274	9	for	for	IN
cord-263645-wupre5uj	274	10	stimulating	stimulate	VBG
cord-263645-wupre5uj	274	11	discussion	discussion	NN
cord-263645-wupre5uj	274	12	and	and	CC
cord-263645-wupre5uj	274	13	input	input	NN
cord-263645-wupre5uj	274	14	.	.	.
cord-263645-wupre5uj	274	15	 	 	_SP