id	sid	tid	token	lemma	pos
cord-263157-8jin6oru	1	1	key	key	JJ
cord-263157-8jin6oru	1	2	:	:	:
cord-263157-8jin6oru	1	3	cord-263157	cord-263157	NNP
cord-263157-8jin6oru	1	4	-	-	HYPH
cord-263157-8jin6oru	1	5	8jin6oru	8jin6oru	CD
cord-263157-8jin6oru	1	6	authors	author	NNS
cord-263157-8jin6oru	1	7	:	:	:
cord-263157-8jin6oru	1	8	Martínez	Martínez	NNP
cord-263157-8jin6oru	1	9	,	,	,
cord-263157-8jin6oru	1	10	Miguel	Miguel	NNP
cord-263157-8jin6oru	1	11	Angel	Angel	NNP
cord-263157-8jin6oru	1	12	title	title	NN
cord-263157-8jin6oru	1	13	:	:	:
cord-263157-8jin6oru	1	14	Progress	progress	VB
cord-263157-8jin6oru	1	15	in	in	IN
cord-263157-8jin6oru	1	16	the	the	DT
cord-263157-8jin6oru	1	17	Therapeutic	Therapeutic	NNP
cord-263157-8jin6oru	1	18	Applications	Applications	NNPS
cord-263157-8jin6oru	1	19	of	of	IN
cord-263157-8jin6oru	1	20	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	1	21	Against	against	IN
cord-263157-8jin6oru	1	22	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	1	23	date	date	NN
cord-263157-8jin6oru	1	24	:	:	:
cord-263157-8jin6oru	1	25	2008	2008	CD
cord-263157-8jin6oru	1	26	-	-	SYM
cord-263157-8jin6oru	1	27	10	10	CD
cord-263157-8jin6oru	1	28	-	-	SYM
cord-263157-8jin6oru	1	29	13	13	CD
cord-263157-8jin6oru	1	30	journal	journal	NN
cord-263157-8jin6oru	1	31	:	:	:
cord-263157-8jin6oru	2	1	siRNA	siRNA	NNP
cord-263157-8jin6oru	2	2	and	and	CC
cord-263157-8jin6oru	2	3	miRNA	miRNA	NNP
cord-263157-8jin6oru	2	4	Gene	Gene	NNP
cord-263157-8jin6oru	2	5	Silencing	Silencing	NNP
cord-263157-8jin6oru	2	6	DOI	doi	NN
cord-263157-8jin6oru	2	7	:	:	:
cord-263157-8jin6oru	3	1	10.1007/978	10.1007/978	LS
cord-263157-8jin6oru	3	2	-	-	HYPH
cord-263157-8jin6oru	3	3	1	1	CD
cord-263157-8jin6oru	3	4	-	-	HYPH
cord-263157-8jin6oru	3	5	60327	60327	CD
cord-263157-8jin6oru	3	6	-	-	HYPH
cord-263157-8jin6oru	3	7	547	547	CD
cord-263157-8jin6oru	3	8	-	-	HYPH
cord-263157-8jin6oru	3	9	7_17	7_17	CD
cord-263157-8jin6oru	4	1	sha	sha	NNP
cord-263157-8jin6oru	4	2	:	:	:
cord-263157-8jin6oru	5	1	d2f08a8ab5e047b8ed80daee5fdb53df7e41882b	d2f08a8ab5e047b8ed80daee5fdb53df7e41882b	UH
cord-263157-8jin6oru	5	2	doc_id	doc_id	CD
cord-263157-8jin6oru	5	3	:	:	:
cord-263157-8jin6oru	5	4	263157	263157	CD
cord-263157-8jin6oru	5	5	cord_uid	cord_uid	NN
cord-263157-8jin6oru	5	6	:	:	:
cord-263157-8jin6oru	6	1	8jin6oru	8jin6oru	CD
cord-263157-8jin6oru	6	2	Therapeutic	therapeutic	JJ
cord-263157-8jin6oru	6	3	options	option	NNS
cord-263157-8jin6oru	6	4	against	against	IN
cord-263157-8jin6oru	6	5	the	the	DT
cord-263157-8jin6oru	6	6	human	human	JJ
cord-263157-8jin6oru	6	7	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	6	8	virus	virus	NN
cord-263157-8jin6oru	6	9	type	type	NN
cord-263157-8jin6oru	6	10	1	1	CD
cord-263157-8jin6oru	6	11	(	(	-LRB-
cord-263157-8jin6oru	6	12	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	6	13	)	)	-RRB-
cord-263157-8jin6oru	6	14	continue	continue	VBP
cord-263157-8jin6oru	6	15	to	to	TO
cord-263157-8jin6oru	6	16	expand	expand	VB
cord-263157-8jin6oru	6	17	with	with	IN
cord-263157-8jin6oru	6	18	the	the	DT
cord-263157-8jin6oru	6	19	development	development	NN
cord-263157-8jin6oru	6	20	of	of	IN
cord-263157-8jin6oru	6	21	new	new	JJ
cord-263157-8jin6oru	6	22	drugs	drug	NNS
cord-263157-8jin6oru	6	23	and	and	CC
cord-263157-8jin6oru	6	24	new	new	JJ
cord-263157-8jin6oru	6	25	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	6	26	strategies	strategy	NNS
cord-263157-8jin6oru	6	27	.	.	.
cord-263157-8jin6oru	7	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	7	2	,	,	,
cord-263157-8jin6oru	7	3	management	management	NN
cord-263157-8jin6oru	7	4	of	of	IN
cord-263157-8jin6oru	7	5	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	7	6	infected	infect	VBN
cord-263157-8jin6oru	7	7	individuals	individual	NNS
cord-263157-8jin6oru	7	8	has	have	VBZ
cord-263157-8jin6oru	7	9	become	become	VBN
cord-263157-8jin6oru	7	10	increasingly	increasingly	RB
cord-263157-8jin6oru	7	11	complex	complex	JJ
cord-263157-8jin6oru	7	12	.	.	.
cord-263157-8jin6oru	8	1	The	the	DT
cord-263157-8jin6oru	8	2	emergence	emergence	NN
cord-263157-8jin6oru	8	3	of	of	IN
cord-263157-8jin6oru	8	4	drug	drug	NN
cord-263157-8jin6oru	8	5	-	-	HYPH
cord-263157-8jin6oru	8	6	resistant	resistant	JJ
cord-263157-8jin6oru	8	7	variants	variant	NNS
cord-263157-8jin6oru	8	8	,	,	,
cord-263157-8jin6oru	8	9	the	the	DT
cord-263157-8jin6oru	8	10	growing	grow	VBG
cord-263157-8jin6oru	8	11	recognition	recognition	NN
cord-263157-8jin6oru	8	12	of	of	IN
cord-263157-8jin6oru	8	13	the	the	DT
cord-263157-8jin6oru	8	14	long	long	JJ
cord-263157-8jin6oru	8	15	-	-	HYPH
cord-263157-8jin6oru	8	16	term	term	NN
cord-263157-8jin6oru	8	17	toxicity	toxicity	NN
cord-263157-8jin6oru	8	18	of	of	IN
cord-263157-8jin6oru	8	19	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	8	20	therapies	therapy	NNS
cord-263157-8jin6oru	8	21	and	and	CC
cord-263157-8jin6oru	8	22	the	the	DT
cord-263157-8jin6oru	8	23	persistence	persistence	NN
cord-263157-8jin6oru	8	24	of	of	IN
cord-263157-8jin6oru	8	25	viral	viral	JJ
cord-263157-8jin6oru	8	26	reservoirs	reservoir	NNS
cord-263157-8jin6oru	8	27	justify	justify	VBP
cord-263157-8jin6oru	8	28	the	the	DT
cord-263157-8jin6oru	8	29	continued	continue	VBN
cord-263157-8jin6oru	8	30	efforts	effort	NNS
cord-263157-8jin6oru	8	31	to	to	TO
cord-263157-8jin6oru	8	32	develop	develop	VB
cord-263157-8jin6oru	8	33	new	new	JJ
cord-263157-8jin6oru	8	34	anti	anti	JJ
cord-263157-8jin6oru	8	35	-	-	JJ
cord-263157-8jin6oru	8	36	HIV-1	hiv-1	JJ
cord-263157-8jin6oru	8	37	strategies	strategy	NNS
cord-263157-8jin6oru	8	38	.	.	.
cord-263157-8jin6oru	9	1	Recent	recent	JJ
cord-263157-8jin6oru	9	2	advances	advance	NNS
cord-263157-8jin6oru	9	3	regarding	regard	VBG
cord-263157-8jin6oru	9	4	the	the	DT
cord-263157-8jin6oru	9	5	utility	utility	NN
cord-263157-8jin6oru	9	6	of	of	IN
cord-263157-8jin6oru	9	7	RNA	RNA	NNP
cord-263157-8jin6oru	9	8	-	-	HYPH
cord-263157-8jin6oru	9	9	mediated	mediate	VBN
cord-263157-8jin6oru	9	10	interference	interference	NN
cord-263157-8jin6oru	9	11	(	(	-LRB-
cord-263157-8jin6oru	9	12	RNAi	RNAi	NNP
cord-263157-8jin6oru	9	13	)	)	-RRB-
cord-263157-8jin6oru	9	14	to	to	TO
cord-263157-8jin6oru	9	15	specifically	specifically	RB
cord-263157-8jin6oru	9	16	inhibit	inhibit	VB
cord-263157-8jin6oru	9	17	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	9	18	replication	replication	NN
cord-263157-8jin6oru	9	19	have	have	VBP
cord-263157-8jin6oru	9	20	opened	open	VBN
cord-263157-8jin6oru	9	21	new	new	JJ
cord-263157-8jin6oru	9	22	possibilities	possibility	NNS
cord-263157-8jin6oru	9	23	for	for	IN
cord-263157-8jin6oru	9	24	the	the	DT
cord-263157-8jin6oru	9	25	development	development	NN
cord-263157-8jin6oru	9	26	of	of	IN
cord-263157-8jin6oru	9	27	gene	gene	NN
cord-263157-8jin6oru	9	28	-	-	HYPH
cord-263157-8jin6oru	9	29	based	base	VBN
cord-263157-8jin6oru	9	30	therapies	therapy	NNS
cord-263157-8jin6oru	9	31	against	against	IN
cord-263157-8jin6oru	9	32	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	9	33	infection	infection	NN
cord-263157-8jin6oru	9	34	.	.	.
cord-263157-8jin6oru	10	1	Here	here	RB
cord-263157-8jin6oru	10	2	,	,	,
cord-263157-8jin6oru	10	3	the	the	DT
cord-263157-8jin6oru	10	4	recent	recent	JJ
cord-263157-8jin6oru	10	5	advances	advance	NNS
cord-263157-8jin6oru	10	6	in	in	IN
cord-263157-8jin6oru	10	7	siRNA	siRNA	NNP
cord-263157-8jin6oru	10	8	-	-	HYPH
cord-263157-8jin6oru	10	9	based	base	VBN
cord-263157-8jin6oru	10	10	therapies	therapy	NNS
cord-263157-8jin6oru	10	11	are	be	VBP
cord-263157-8jin6oru	10	12	reviewed	review	VBN
cord-263157-8jin6oru	10	13	.	.	.
cord-263157-8jin6oru	11	1	Although	although	IN
cord-263157-8jin6oru	11	2	a	a	DT
cord-263157-8jin6oru	11	3	few	few	JJ
cord-263157-8jin6oru	11	4	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	11	5	infected	infect	VBN
cord-263157-8jin6oru	11	6	individuals	individual	NNS
cord-263157-8jin6oru	11	7	have	have	VBP
cord-263157-8jin6oru	11	8	remained	remain	VBN
cord-263157-8jin6oru	11	9	healthy	healthy	JJ
cord-263157-8jin6oru	11	10	for	for	IN
cord-263157-8jin6oru	11	11	nearly	nearly	RB
cord-263157-8jin6oru	11	12	18	18	CD
cord-263157-8jin6oru	11	13	years	year	NNS
cord-263157-8jin6oru	11	14	(	(	-LRB-
cord-263157-8jin6oru	11	15	2	2	CD
cord-263157-8jin6oru	11	16	,	,	,
cord-263157-8jin6oru	11	17	3	3	CD
cord-263157-8jin6oru	11	18	)	)	-RRB-
cord-263157-8jin6oru	11	19	to	to	IN
cord-263157-8jin6oru	11	20	date	date	NN
cord-263157-8jin6oru	11	21	not	not	RB
cord-263157-8jin6oru	11	22	a	a	DT
cord-263157-8jin6oru	11	23	single	single	JJ
cord-263157-8jin6oru	11	24	spontaneous	spontaneous	JJ
cord-263157-8jin6oru	11	25	cure	cure	NN
cord-263157-8jin6oru	11	26	of	of	IN
cord-263157-8jin6oru	11	27	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	11	28	infection	infection	NN
cord-263157-8jin6oru	11	29	has	have	VBZ
cord-263157-8jin6oru	11	30	been	be	VBN
cord-263157-8jin6oru	11	31	confirmed	confirm	VBN
cord-263157-8jin6oru	11	32	,	,	,
cord-263157-8jin6oru	11	33	and	and	CC
cord-263157-8jin6oru	11	34	infected	infect	VBN
cord-263157-8jin6oru	11	35	individuals	individual	NNS
cord-263157-8jin6oru	11	36	have	have	VBP
cord-263157-8jin6oru	11	37	either	either	CC
cord-263157-8jin6oru	11	38	died	die	VBN
cord-263157-8jin6oru	11	39	or	or	CC
cord-263157-8jin6oru	11	40	remained	remain	VBD
cord-263157-8jin6oru	11	41	infected	infected	JJ
cord-263157-8jin6oru	11	42	.	.	.
cord-263157-8jin6oru	12	1	Therefore	therefore	RB
cord-263157-8jin6oru	12	2	,	,	,
cord-263157-8jin6oru	12	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	12	4	poses	pose	VBZ
cord-263157-8jin6oru	12	5	a	a	DT
cord-263157-8jin6oru	12	6	greater	great	JJR
cord-263157-8jin6oru	12	7	challenge	challenge	NN
cord-263157-8jin6oru	12	8	to	to	IN
cord-263157-8jin6oru	12	9	the	the	DT
cord-263157-8jin6oru	12	10	development	development	NN
cord-263157-8jin6oru	12	11	of	of	IN
cord-263157-8jin6oru	12	12	classic	classic	JJ
cord-263157-8jin6oru	12	13	vaccination	vaccination	NN
cord-263157-8jin6oru	12	14	or	or	CC
cord-263157-8jin6oru	12	15	antiviral	antiviral	JJ
cord-263157-8jin6oru	12	16	strategies	strategy	NNS
cord-263157-8jin6oru	12	17	geared	gear	VBN
cord-263157-8jin6oru	12	18	to	to	TO
cord-263157-8jin6oru	12	19	ultimately	ultimately	RB
cord-263157-8jin6oru	12	20	lead	lead	VB
cord-263157-8jin6oru	12	21	to	to	IN
cord-263157-8jin6oru	12	22	the	the	DT
cord-263157-8jin6oru	12	23	eradication	eradication	NN
cord-263157-8jin6oru	12	24	of	of	IN
cord-263157-8jin6oru	12	25	the	the	DT
cord-263157-8jin6oru	12	26	virus	virus	NN
cord-263157-8jin6oru	12	27	.	.	.
cord-263157-8jin6oru	13	1	A	a	DT
cord-263157-8jin6oru	13	2	safe	safe	JJ
cord-263157-8jin6oru	13	3	and	and	CC
cord-263157-8jin6oru	13	4	effective	effective	JJ
cord-263157-8jin6oru	13	5	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	13	6	vaccine	vaccine	NN
cord-263157-8jin6oru	13	7	to	to	TO
cord-263157-8jin6oru	13	8	stop	stop	VB
cord-263157-8jin6oru	13	9	the	the	DT
cord-263157-8jin6oru	13	10	spread	spread	NN
cord-263157-8jin6oru	13	11	of	of	IN
cord-263157-8jin6oru	13	12	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	13	13	has	have	VBZ
cord-263157-8jin6oru	13	14	not	not	RB
cord-263157-8jin6oru	13	15	yet	yet	RB
cord-263157-8jin6oru	13	16	been	be	VBN
cord-263157-8jin6oru	13	17	developed	develop	VBN
cord-263157-8jin6oru	13	18	and	and	CC
cord-263157-8jin6oru	13	19	the	the	DT
cord-263157-8jin6oru	13	20	possibility	possibility	NN
cord-263157-8jin6oru	13	21	of	of	IN
cord-263157-8jin6oru	13	22	developing	develop	VBG
cord-263157-8jin6oru	13	23	a	a	DT
cord-263157-8jin6oru	13	24	successful	successful	JJ
cord-263157-8jin6oru	13	25	vaccine	vaccine	NN
cord-263157-8jin6oru	13	26	in	in	IN
cord-263157-8jin6oru	13	27	the	the	DT
cord-263157-8jin6oru	13	28	near	near	JJ
cord-263157-8jin6oru	13	29	future	future	NN
cord-263157-8jin6oru	13	30	remains	remain	VBZ
cord-263157-8jin6oru	13	31	to	to	TO
cord-263157-8jin6oru	13	32	be	be	VB
cord-263157-8jin6oru	13	33	seen	see	VBN
cord-263157-8jin6oru	13	34	(	(	-LRB-
cord-263157-8jin6oru	13	35	4	4	CD
cord-263157-8jin6oru	13	36	)	)	-RRB-
cord-263157-8jin6oru	13	37	.	.	.
cord-263157-8jin6oru	14	1	The	the	DT
cord-263157-8jin6oru	14	2	introduction	introduction	NN
cord-263157-8jin6oru	14	3	of	of	IN
cord-263157-8jin6oru	14	4	potent	potent	JJ
cord-263157-8jin6oru	14	5	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	14	6	therapies	therapy	NNS
cord-263157-8jin6oru	14	7	has	have	VBZ
cord-263157-8jin6oru	14	8	been	be	VBN
cord-263157-8jin6oru	14	9	an	an	DT
cord-263157-8jin6oru	14	10	important	important	JJ
cord-263157-8jin6oru	14	11	achievement	achievement	NN
cord-263157-8jin6oru	14	12	towards	towards	IN
cord-263157-8jin6oru	14	13	the	the	DT
cord-263157-8jin6oru	14	14	control	control	NN
cord-263157-8jin6oru	14	15	of	of	IN
cord-263157-8jin6oru	14	16	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	14	17	infection	infection	NN
cord-263157-8jin6oru	14	18	and	and	CC
cord-263157-8jin6oru	14	19	AIDS	AIDS	NNP
cord-263157-8jin6oru	14	20	(	(	-LRB-
cord-263157-8jin6oru	14	21	5	5	CD
cord-263157-8jin6oru	14	22	,	,	,
cord-263157-8jin6oru	14	23	see	see	VB
cord-263157-8jin6oru	14	24	Table	Table	NNP
cord-263157-8jin6oru	14	25	17	17	CD
cord-263157-8jin6oru	14	26	.1	.1	CD
cord-263157-8jin6oru	14	27	)	)	-RRB-
cord-263157-8jin6oru	14	28	.	.	.
cord-263157-8jin6oru	15	1	Therapies	therapy	NNS
cord-263157-8jin6oru	15	2	to	to	TO
cord-263157-8jin6oru	15	3	combat	combat	VB
cord-263157-8jin6oru	15	4	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	15	5	infection	infection	NN
cord-263157-8jin6oru	15	6	have	have	VBP
cord-263157-8jin6oru	15	7	resulted	result	VBN
cord-263157-8jin6oru	15	8	in	in	IN
cord-263157-8jin6oru	15	9	a	a	DT
cord-263157-8jin6oru	15	10	dramatic	dramatic	JJ
cord-263157-8jin6oru	15	11	decrease	decrease	NN
cord-263157-8jin6oru	15	12	in	in	IN
cord-263157-8jin6oru	15	13	AIDS	AIDS	NNP
cord-263157-8jin6oru	15	14	-	-	HYPH
cord-263157-8jin6oru	15	15	associated	associate	VBN
cord-263157-8jin6oru	15	16	morbidity	morbidity	NN
cord-263157-8jin6oru	15	17	and	and	CC
cord-263157-8jin6oru	15	18	mortality	mortality	NN
cord-263157-8jin6oru	15	19	in	in	IN
cord-263157-8jin6oru	15	20	developed	develop	VBN
cord-263157-8jin6oru	15	21	countries	country	NNS
cord-263157-8jin6oru	15	22	(	(	-LRB-
cord-263157-8jin6oru	15	23	6	6	CD
cord-263157-8jin6oru	15	24	)	)	-RRB-
cord-263157-8jin6oru	15	25	.	.	.
cord-263157-8jin6oru	16	1	Despite	despite	IN
cord-263157-8jin6oru	16	2	the	the	DT
cord-263157-8jin6oru	16	3	development	development	NN
cord-263157-8jin6oru	16	4	of	of	IN
cord-263157-8jin6oru	16	5	successful	successful	JJ
cord-263157-8jin6oru	16	6	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	16	7	strategies	strategy	NNS
cord-263157-8jin6oru	16	8	employing	employ	VBG
cord-263157-8jin6oru	16	9	treatment	treatment	NN
cord-263157-8jin6oru	16	10	combinations	combination	NNS
cord-263157-8jin6oru	16	11	,	,	,
cord-263157-8jin6oru	16	12	or	or	CC
cord-263157-8jin6oru	16	13	highly	highly	RB
cord-263157-8jin6oru	16	14	active	active	JJ
cord-263157-8jin6oru	16	15	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	16	16	therapy	therapy	NN
cord-263157-8jin6oru	16	17	(	(	-LRB-
cord-263157-8jin6oru	16	18	HAART	HAART	NNP
cord-263157-8jin6oru	16	19	)	)	-RRB-
cord-263157-8jin6oru	16	20	,	,	,
cord-263157-8jin6oru	16	21	it	-PRON-	PRP
cord-263157-8jin6oru	16	22	has	have	VBZ
cord-263157-8jin6oru	16	23	not	not	RB
cord-263157-8jin6oru	16	24	been	be	VBN
cord-263157-8jin6oru	16	25	possible	possible	JJ
cord-263157-8jin6oru	16	26	to	to	TO
cord-263157-8jin6oru	16	27	eradicate	eradicate	VB
cord-263157-8jin6oru	16	28	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	16	29	in	in	IN
cord-263157-8jin6oru	16	30	infected	infected	JJ
cord-263157-8jin6oru	16	31	individuals	individual	NNS
cord-263157-8jin6oru	16	32	,	,	,
cord-263157-8jin6oru	16	33	mainly	mainly	RB
cord-263157-8jin6oru	16	34	due	due	IN
cord-263157-8jin6oru	16	35	to	to	IN
cord-263157-8jin6oru	16	36	the	the	DT
cord-263157-8jin6oru	16	37	persistence	persistence	NN
cord-263157-8jin6oru	16	38	of	of	IN
cord-263157-8jin6oru	16	39	viral	viral	JJ
cord-263157-8jin6oru	16	40	reservoirs	reservoir	NNS
cord-263157-8jin6oru	16	41	(	(	-LRB-
cord-263157-8jin6oru	16	42	7	7	CD
cord-263157-8jin6oru	16	43	,	,	,
cord-263157-8jin6oru	16	44	8	8	CD
cord-263157-8jin6oru	16	45	,	,	,
cord-263157-8jin6oru	16	46	9	9	CD
cord-263157-8jin6oru	16	47	,	,	,
cord-263157-8jin6oru	16	48	10	10	CD
cord-263157-8jin6oru	16	49	)	)	-RRB-
cord-263157-8jin6oru	16	50	.	.	.
cord-263157-8jin6oru	17	1	The	the	DT
cord-263157-8jin6oru	17	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	17	3	reservoir	reservoir	NN
cord-263157-8jin6oru	17	4	is	be	VBZ
cord-263157-8jin6oru	17	5	not	not	RB
cord-263157-8jin6oru	17	6	eradicated	eradicate	VBN
cord-263157-8jin6oru	17	7	even	even	RB
cord-263157-8jin6oru	17	8	after	after	IN
cord-263157-8jin6oru	17	9	extended	extend	VBN
cord-263157-8jin6oru	17	10	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	17	11	therapy	therapy	NN
cord-263157-8jin6oru	17	12	that	that	WDT
cord-263157-8jin6oru	17	13	can	can	MD
cord-263157-8jin6oru	17	14	reduce	reduce	VB
cord-263157-8jin6oru	17	15	viremia	viremia	NN
cord-263157-8jin6oru	17	16	to	to	IN
cord-263157-8jin6oru	17	17	undetectable	undetectable	JJ
cord-263157-8jin6oru	17	18	levels	level	NNS
cord-263157-8jin6oru	17	19	(	(	-LRB-
cord-263157-8jin6oru	17	20	<	<	XX
cord-263157-8jin6oru	17	21	50	50	CD
cord-263157-8jin6oru	17	22	viral	viral	JJ
cord-263157-8jin6oru	17	23	RNA	RNA	NNP
cord-263157-8jin6oru	17	24	copies	copy	NNS
cord-263157-8jin6oru	17	25	per	per	IN
cord-263157-8jin6oru	17	26	milliliter	milliliter	NN
cord-263157-8jin6oru	17	27	of	of	IN
cord-263157-8jin6oru	17	28	plasma	plasma	NN
cord-263157-8jin6oru	17	29	)	)	-RRB-
cord-263157-8jin6oru	17	30	.	.	.
cord-263157-8jin6oru	18	1	Therefore	therefore	RB
cord-263157-8jin6oru	18	2	,	,	,
cord-263157-8jin6oru	18	3	individuals	individual	NNS
cord-263157-8jin6oru	18	4	infected	infect	VBN
cord-263157-8jin6oru	18	5	with	with	IN
cord-263157-8jin6oru	18	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	18	7	need	need	VBP
cord-263157-8jin6oru	18	8	to	to	TO
cord-263157-8jin6oru	18	9	receive	receive	VB
cord-263157-8jin6oru	18	10	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	18	11	therapy	therapy	NN
cord-263157-8jin6oru	18	12	for	for	IN
cord-263157-8jin6oru	18	13	many	many	JJ
cord-263157-8jin6oru	18	14	years	year	NNS
cord-263157-8jin6oru	18	15	,	,	,
cord-263157-8jin6oru	18	16	if	if	IN
cord-263157-8jin6oru	18	17	not	not	RB
cord-263157-8jin6oru	18	18	for	for	IN
cord-263157-8jin6oru	18	19	life	life	NN
cord-263157-8jin6oru	18	20	.	.	.
cord-263157-8jin6oru	19	1	Current	current	JJ
cord-263157-8jin6oru	19	2	treatments	treatment	NNS
cord-263157-8jin6oru	19	3	target	target	VBP
cord-263157-8jin6oru	19	4	viral	viral	JJ
cord-263157-8jin6oru	19	5	enzymes	enzyme	NNS
cord-263157-8jin6oru	19	6	,	,	,
cord-263157-8jin6oru	19	7	such	such	JJ
cord-263157-8jin6oru	19	8	as	as	IN
cord-263157-8jin6oru	19	9	the	the	DT
cord-263157-8jin6oru	19	10	reverse	reverse	JJ
cord-263157-8jin6oru	19	11	transcriptase	transcriptase	NN
cord-263157-8jin6oru	19	12	(	(	-LRB-
cord-263157-8jin6oru	19	13	RT	RT	NNP
cord-263157-8jin6oru	19	14	)	)	-RRB-
cord-263157-8jin6oru	19	15	and	and	CC
cord-263157-8jin6oru	19	16	protease	protease	NN
cord-263157-8jin6oru	19	17	,	,	,
cord-263157-8jin6oru	19	18	as	as	RB
cord-263157-8jin6oru	19	19	well	well	RB
cord-263157-8jin6oru	19	20	as	as	IN
cord-263157-8jin6oru	19	21	the	the	DT
cord-263157-8jin6oru	19	22	envelope	envelope	NN
cord-263157-8jin6oru	19	23	glycoprotein	glycoprotein	NN
cord-263157-8jin6oru	19	24	gp41	gp41	NNP
cord-263157-8jin6oru	19	25	(	(	-LRB-
cord-263157-8jin6oru	19	26	Table	Table	NNP
cord-263157-8jin6oru	19	27	17	17	CD
cord-263157-8jin6oru	19	28	.1	.1	CD
cord-263157-8jin6oru	19	29	)	)	-RRB-
cord-263157-8jin6oru	19	30	.	.	.
cord-263157-8jin6oru	20	1	The	the	DT
cord-263157-8jin6oru	20	2	most	most	RBS
cord-263157-8jin6oru	20	3	recent	recent	JJ
cord-263157-8jin6oru	20	4	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	20	5	approved	approve	VBN
cord-263157-8jin6oru	20	6	for	for	IN
cord-263157-8jin6oru	20	7	clinical	clinical	JJ
cord-263157-8jin6oru	20	8	use	use	NN
cord-263157-8jin6oru	20	9	blocks	block	VBZ
cord-263157-8jin6oru	20	10	the	the	DT
cord-263157-8jin6oru	20	11	binding	binding	NN
cord-263157-8jin6oru	20	12	of	of	IN
cord-263157-8jin6oru	20	13	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	20	14	to	to	IN
cord-263157-8jin6oru	20	15	its	-PRON-	PRP$
cord-263157-8jin6oru	20	16	co	co	JJ
cord-263157-8jin6oru	20	17	-	-	NN
cord-263157-8jin6oru	20	18	receptor	receptor	NN
cord-263157-8jin6oru	20	19	CCR5	CCR5	NNP
cord-263157-8jin6oru	20	20	in	in	IN
cord-263157-8jin6oru	20	21	host	host	NN
cord-263157-8jin6oru	20	22	cells	cell	NNS
cord-263157-8jin6oru	20	23	(	(	-LRB-
cord-263157-8jin6oru	20	24	11	11	CD
cord-263157-8jin6oru	20	25	)	)	-RRB-
cord-263157-8jin6oru	20	26	.	.	.
cord-263157-8jin6oru	21	1	Despite	despite	IN
cord-263157-8jin6oru	21	2	the	the	DT
cord-263157-8jin6oru	21	3	success	success	NN
cord-263157-8jin6oru	21	4	of	of	IN
cord-263157-8jin6oru	21	5	potent	potent	JJ
cord-263157-8jin6oru	21	6	combination	combination	NN
cord-263157-8jin6oru	21	7	regimens	regimen	NNS
cord-263157-8jin6oru	21	8	,	,	,
cord-263157-8jin6oru	21	9	the	the	DT
cord-263157-8jin6oru	21	10	development	development	NN
cord-263157-8jin6oru	21	11	of	of	IN
cord-263157-8jin6oru	21	12	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	21	13	drug	drug	NN
cord-263157-8jin6oru	21	14	resistance	resistance	NN
cord-263157-8jin6oru	21	15	constitutes	constitute	VBZ
cord-263157-8jin6oru	21	16	a	a	DT
cord-263157-8jin6oru	21	17	major	major	JJ
cord-263157-8jin6oru	21	18	hurdle	hurdle	NN
cord-263157-8jin6oru	21	19	towards	towards	IN
cord-263157-8jin6oru	21	20	longterm	longterm	JJ
cord-263157-8jin6oru	21	21	efficacy	efficacy	NN
cord-263157-8jin6oru	21	22	of	of	IN
cord-263157-8jin6oru	21	23	current	current	JJ
cord-263157-8jin6oru	21	24	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	21	25	therapies	therapy	NNS
cord-263157-8jin6oru	21	26	(	(	-LRB-
cord-263157-8jin6oru	21	27	12	12	CD
cord-263157-8jin6oru	21	28	)	)	-RRB-
cord-263157-8jin6oru	21	29	.	.	.
cord-263157-8jin6oru	22	1	Moreover	moreover	RB
cord-263157-8jin6oru	22	2	,	,	,
cord-263157-8jin6oru	22	3	just	just	RB
cord-263157-8jin6oru	22	4	several	several	JJ
cord-263157-8jin6oru	22	5	years	year	NNS
cord-263157-8jin6oru	22	6	after	after	IN
cord-263157-8jin6oru	22	7	the	the	DT
cord-263157-8jin6oru	22	8	implementation	implementation	NN
cord-263157-8jin6oru	22	9	of	of	IN
cord-263157-8jin6oru	22	10	HAART	HAART	NNP
cord-263157-8jin6oru	22	11	,	,	,
cord-263157-8jin6oru	22	12	the	the	DT
cord-263157-8jin6oru	22	13	increase	increase	NN
cord-263157-8jin6oru	22	14	of	of	IN
cord-263157-8jin6oru	22	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	22	16	drug	drug	NN
cord-263157-8jin6oru	22	17	resistance	resistance	NN
cord-263157-8jin6oru	22	18	has	have	VBZ
cord-263157-8jin6oru	22	19	required	require	VBN
cord-263157-8jin6oru	22	20	the	the	DT
cord-263157-8jin6oru	22	21	initiation	initiation	NN
cord-263157-8jin6oru	22	22	of	of	IN
cord-263157-8jin6oru	22	23	a	a	DT
cord-263157-8jin6oru	22	24	continuous	continuous	JJ
cord-263157-8jin6oru	22	25	effort	effort	NN
cord-263157-8jin6oru	22	26	in	in	IN
cord-263157-8jin6oru	22	27	the	the	DT
cord-263157-8jin6oru	22	28	development	development	NN
cord-263157-8jin6oru	22	29	of	of	IN
cord-263157-8jin6oru	22	30	new	new	JJ
cord-263157-8jin6oru	22	31	drugs	drug	NNS
cord-263157-8jin6oru	22	32	,	,	,
cord-263157-8jin6oru	22	33	therapy	therapy	NN
cord-263157-8jin6oru	22	34	strategies	strategy	NNS
cord-263157-8jin6oru	22	35	and	and	CC
cord-263157-8jin6oru	22	36	viral	viral	JJ
cord-263157-8jin6oru	22	37	targets	target	NNS
cord-263157-8jin6oru	22	38	.	.	.
cord-263157-8jin6oru	23	1	So	so	RB
cord-263157-8jin6oru	23	2	far	far	RB
cord-263157-8jin6oru	23	3	,	,	,
cord-263157-8jin6oru	23	4	22	22	CD
cord-263157-8jin6oru	23	5	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	23	6	drugs	drug	NNS
cord-263157-8jin6oru	23	7	have	have	VBP
cord-263157-8jin6oru	23	8	been	be	VBN
cord-263157-8jin6oru	23	9	approved	approve	VBN
cord-263157-8jin6oru	23	10	and	and	CC
cord-263157-8jin6oru	23	11	several	several	JJ
cord-263157-8jin6oru	23	12	others	other	NNS
cord-263157-8jin6oru	23	13	are	be	VBP
cord-263157-8jin6oru	23	14	in	in	IN
cord-263157-8jin6oru	23	15	clinical	clinical	JJ
cord-263157-8jin6oru	23	16	or	or	CC
cord-263157-8jin6oru	23	17	preclinical	preclinical	JJ
cord-263157-8jin6oru	23	18	development	development	NN
cord-263157-8jin6oru	23	19	(	(	-LRB-
cord-263157-8jin6oru	23	20	Table	Table	NNP
cord-263157-8jin6oru	23	21	 	 	_SP
cord-263157-8jin6oru	23	22	17	17	CD
cord-263157-8jin6oru	23	23	.1	.1	CD
cord-263157-8jin6oru	23	24	)	)	-RRB-
cord-263157-8jin6oru	23	25	.	.	.
cord-263157-8jin6oru	24	1	Current	current	JJ
cord-263157-8jin6oru	24	2	limitations	limitation	NNS
cord-263157-8jin6oru	24	3	of	of	IN
cord-263157-8jin6oru	24	4	HAART	HAART	NNP
cord-263157-8jin6oru	24	5	are	be	VBP
cord-263157-8jin6oru	24	6	not	not	RB
cord-263157-8jin6oru	24	7	restricted	restrict	VBN
cord-263157-8jin6oru	24	8	to	to	IN
cord-263157-8jin6oru	24	9	drug	drug	NN
cord-263157-8jin6oru	24	10	resistance	resistance	NN
cord-263157-8jin6oru	24	11	.	.	.
cord-263157-8jin6oru	25	1	Toxicity	toxicity	NN
cord-263157-8jin6oru	25	2	and	and	CC
cord-263157-8jin6oru	25	3	side	side	NN
cord-263157-8jin6oru	25	4	effects	effect	NNS
cord-263157-8jin6oru	25	5	,	,	,
cord-263157-8jin6oru	25	6	such	such	JJ
cord-263157-8jin6oru	25	7	as	as	IN
cord-263157-8jin6oru	25	8	hyperlipidemia	hyperlipidemia	NN
cord-263157-8jin6oru	25	9	,	,	,
cord-263157-8jin6oru	25	10	hyperglycemia	hyperglycemia	NN
cord-263157-8jin6oru	25	11	,	,	,
cord-263157-8jin6oru	25	12	hypersensitivity	hypersensitivity	NN
cord-263157-8jin6oru	25	13	,	,	,
cord-263157-8jin6oru	25	14	pancreatitis	pancreatitis	NN
cord-263157-8jin6oru	25	15	,	,	,
cord-263157-8jin6oru	25	16	lipoatrophy	lipoatrophy	NN
cord-263157-8jin6oru	25	17	,	,	,
cord-263157-8jin6oru	25	18	anemia	anemia	NN
cord-263157-8jin6oru	25	19	and	and	CC
cord-263157-8jin6oru	25	20	neutropenia	neutropenia	NN
cord-263157-8jin6oru	25	21	,	,	,
cord-263157-8jin6oru	25	22	rash	rash	JJ
cord-263157-8jin6oru	25	23	,	,	,
cord-263157-8jin6oru	25	24	diarrhoea	diarrhoea	NN
cord-263157-8jin6oru	25	25	,	,	,
cord-263157-8jin6oru	25	26	gastrointestinal	gastrointestinal	JJ
cord-263157-8jin6oru	25	27	distress	distress	NN
cord-263157-8jin6oru	25	28	,	,	,
cord-263157-8jin6oru	25	29	insulin	insulin	NN
cord-263157-8jin6oru	25	30	resistance	resistance	NN
cord-263157-8jin6oru	25	31	,	,	,
cord-263157-8jin6oru	25	32	immune	immune	JJ
cord-263157-8jin6oru	25	33	reconstitution	reconstitution	NN
cord-263157-8jin6oru	25	34	syndrome	syndrome	NN
cord-263157-8jin6oru	25	35	,	,	,
cord-263157-8jin6oru	25	36	renal	renal	JJ
cord-263157-8jin6oru	25	37	dysfunction	dysfunction	NN
cord-263157-8jin6oru	25	38	,	,	,
cord-263157-8jin6oru	25	39	hepatotoxicity	hepatotoxicity	NN
cord-263157-8jin6oru	25	40	and	and	CC
cord-263157-8jin6oru	25	41	an	an	DT
cord-263157-8jin6oru	25	42	increased	increase	VBN
cord-263157-8jin6oru	25	43	risk	risk	NN
cord-263157-8jin6oru	25	44	of	of	IN
cord-263157-8jin6oru	25	45	liver	liver	NN
cord-263157-8jin6oru	25	46	cirrhosis	cirrhosis	NN
cord-263157-8jin6oru	25	47	and	and	CC
cord-263157-8jin6oru	25	48	myocardial	myocardial	JJ
cord-263157-8jin6oru	25	49	infarction	infarction	NN
cord-263157-8jin6oru	25	50	have	have	VBP
cord-263157-8jin6oru	25	51	all	all	DT
cord-263157-8jin6oru	25	52	been	be	VBN
cord-263157-8jin6oru	25	53	described	describe	VBN
cord-263157-8jin6oru	25	54	in	in	IN
cord-263157-8jin6oru	25	55	response	response	NN
cord-263157-8jin6oru	25	56	to	to	IN
cord-263157-8jin6oru	25	57	treatment	treatment	NN
cord-263157-8jin6oru	25	58	with	with	IN
cord-263157-8jin6oru	25	59	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	25	60	drugs	drug	NNS
cord-263157-8jin6oru	25	61	(	(	-LRB-
cord-263157-8jin6oru	25	62	13	13	CD
cord-263157-8jin6oru	25	63	)	)	-RRB-
cord-263157-8jin6oru	25	64	.	.	.
cord-263157-8jin6oru	26	1	Moreover	moreover	RB
cord-263157-8jin6oru	26	2	,	,	,
cord-263157-8jin6oru	26	3	the	the	DT
cord-263157-8jin6oru	26	4	likelihood	likelihood	NN
cord-263157-8jin6oru	26	5	of	of	IN
cord-263157-8jin6oru	26	6	side	side	NN
cord-263157-8jin6oru	26	7	effects	effect	NNS
cord-263157-8jin6oru	26	8	increases	increase	NNS
cord-263157-8jin6oru	26	9	due	due	JJ
cord-263157-8jin6oru	26	10	to	to	IN
cord-263157-8jin6oru	26	11	the	the	DT
cord-263157-8jin6oru	26	12	improved	improved	JJ
cord-263157-8jin6oru	26	13	lifespan	lifespan	NN
cord-263157-8jin6oru	26	14	as	as	IN
cord-263157-8jin6oru	26	15	a	a	DT
cord-263157-8jin6oru	26	16	result	result	NN
cord-263157-8jin6oru	26	17	of	of	IN
cord-263157-8jin6oru	26	18	the	the	DT
cord-263157-8jin6oru	26	19	success	success	NN
cord-263157-8jin6oru	26	20	of	of	IN
cord-263157-8jin6oru	26	21	HAART	HAART	NNP
cord-263157-8jin6oru	26	22	.	.	.
cord-263157-8jin6oru	27	1	Finally	finally	RB
cord-263157-8jin6oru	27	2	,	,	,
cord-263157-8jin6oru	27	3	coinfection	coinfection	NN
cord-263157-8jin6oru	27	4	with	with	IN
cord-263157-8jin6oru	27	5	hepatitis	hepatitis	NN
cord-263157-8jin6oru	27	6	C	C	NNP
cord-263157-8jin6oru	27	7	,	,	,
cord-263157-8jin6oru	27	8	hepatitis	hepatitis	NN
cord-263157-8jin6oru	27	9	B	b	NN
cord-263157-8jin6oru	27	10	,	,	,
cord-263157-8jin6oru	27	11	tuberculosis	tuberculosis	NN
cord-263157-8jin6oru	27	12	or	or	CC
cord-263157-8jin6oru	27	13	malaria	malaria	NN
cord-263157-8jin6oru	27	14	complicates	complicate	VBZ
cord-263157-8jin6oru	27	15	the	the	DT
cord-263157-8jin6oru	27	16	treatment	treatment	NN
cord-263157-8jin6oru	27	17	regimens	regimen	NNS
cord-263157-8jin6oru	27	18	for	for	IN
cord-263157-8jin6oru	27	19	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	27	20	infected	infect	VBN
cord-263157-8jin6oru	27	21	individuals	individual	NNS
cord-263157-8jin6oru	27	22	.	.	.
cord-263157-8jin6oru	28	1	The	the	DT
cord-263157-8jin6oru	28	2	limitations	limitation	NNS
cord-263157-8jin6oru	28	3	and	and	CC
cord-263157-8jin6oru	28	4	challenges	challenge	NNS
cord-263157-8jin6oru	28	5	of	of	IN
cord-263157-8jin6oru	28	6	current	current	JJ
cord-263157-8jin6oru	28	7	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	28	8	therapy	therapy	NN
cord-263157-8jin6oru	28	9	justify	justify	VB
cord-263157-8jin6oru	28	10	the	the	DT
cord-263157-8jin6oru	28	11	continued	continued	JJ
cord-263157-8jin6oru	28	12	effort	effort	NN
cord-263157-8jin6oru	28	13	to	to	TO
cord-263157-8jin6oru	28	14	develop	develop	VB
cord-263157-8jin6oru	28	15	new	new	JJ
cord-263157-8jin6oru	28	16	anti	anti	JJ
cord-263157-8jin6oru	28	17	-	-	JJ
cord-263157-8jin6oru	28	18	HIV-1	hiv-1	JJ
cord-263157-8jin6oru	28	19	strategies	strategy	NNS
cord-263157-8jin6oru	28	20	.	.	.
cord-263157-8jin6oru	29	1	Fire	Fire	NNP
cord-263157-8jin6oru	29	2	et	et	NNP
cord-263157-8jin6oru	29	3	al	al	NNP
cord-263157-8jin6oru	29	4	.	.	.
cord-263157-8jin6oru	30	1	first	first	RB
cord-263157-8jin6oru	30	2	discovered	discover	VBD
cord-263157-8jin6oru	30	3	that	that	IN
cord-263157-8jin6oru	30	4	introducing	introduce	VBG
cord-263157-8jin6oru	30	5	long	long	JJ
cord-263157-8jin6oru	30	6	double	double	RB
cord-263157-8jin6oru	30	7	-	-	HYPH
cord-263157-8jin6oru	30	8	stranded	strand	VBN
cord-263157-8jin6oru	30	9	RNA	RNA	NNP
cord-263157-8jin6oru	30	10	(	(	-LRB-
cord-263157-8jin6oru	30	11	dsRNA	dsrna	NN
cord-263157-8jin6oru	30	12	)	)	-RRB-
cord-263157-8jin6oru	30	13	into	into	IN
cord-263157-8jin6oru	30	14	the	the	DT
cord-263157-8jin6oru	30	15	nematode	nematode	NN
cord-263157-8jin6oru	30	16	Caenorhabditis	Caenorhabditis	NNP
cord-263157-8jin6oru	30	17	elegans	elegan	NNS
cord-263157-8jin6oru	30	18	led	lead	VBD
cord-263157-8jin6oru	30	19	to	to	IN
cord-263157-8jin6oru	30	20	the	the	DT
cord-263157-8jin6oru	30	21	targeted	target	VBN
cord-263157-8jin6oru	30	22	degradation	degradation	NN
cord-263157-8jin6oru	30	23	of	of	IN
cord-263157-8jin6oru	30	24	homologous	homologous	JJ
cord-263157-8jin6oru	30	25	mRNA	mrna	NN
cord-263157-8jin6oru	30	26	,	,	,
cord-263157-8jin6oru	30	27	revealing	reveal	VBG
cord-263157-8jin6oru	30	28	the	the	DT
cord-263157-8jin6oru	30	29	existence	existence	NN
cord-263157-8jin6oru	30	30	of	of	IN
cord-263157-8jin6oru	30	31	a	a	DT
cord-263157-8jin6oru	30	32	fundamental	fundamental	JJ
cord-263157-8jin6oru	30	33	mechanism	mechanism	NN
cord-263157-8jin6oru	30	34	now	now	RB
cord-263157-8jin6oru	30	35	known	know	VBN
cord-263157-8jin6oru	30	36	as	as	IN
cord-263157-8jin6oru	30	37	RNAi	RNAi	NNS
cord-263157-8jin6oru	30	38	through	through	IN
cord-263157-8jin6oru	30	39	which	which	WDT
cord-263157-8jin6oru	30	40	gene	gene	NN
cord-263157-8jin6oru	30	41	expression	expression	NN
cord-263157-8jin6oru	30	42	can	can	MD
cord-263157-8jin6oru	30	43	be	be	VB
cord-263157-8jin6oru	30	44	regulated	regulate	VBN
cord-263157-8jin6oru	30	45	(	(	-LRB-
cord-263157-8jin6oru	30	46	14	14	CD
cord-263157-8jin6oru	30	47	)	)	-RRB-
cord-263157-8jin6oru	30	48	.	.	.
cord-263157-8jin6oru	31	1	Later	later	JJ
cord-263157-8jin6oru	31	2	findings	finding	NNS
cord-263157-8jin6oru	31	3	by	by	IN
cord-263157-8jin6oru	31	4	Elbashir	Elbashir	NNP
cord-263157-8jin6oru	31	5	et	et	NNP
cord-263157-8jin6oru	31	6	al	al	NNP
cord-263157-8jin6oru	31	7	.	.	NNP
cord-263157-8jin6oru	31	8	showed	show	VBD
cord-263157-8jin6oru	31	9	that	that	IN
cord-263157-8jin6oru	31	10	RNAi	RNAi	NNP
cord-263157-8jin6oru	31	11	also	also	RB
cord-263157-8jin6oru	31	12	occurs	occur	VBZ
cord-263157-8jin6oru	31	13	in	in	IN
cord-263157-8jin6oru	31	14	mammalians	mammalians	NNP
cord-263157-8jin6oru	31	15	cells	cell	NNS
cord-263157-8jin6oru	31	16	(	(	-LRB-
cord-263157-8jin6oru	31	17	15	15	CD
cord-263157-8jin6oru	31	18	)	)	-RRB-
cord-263157-8jin6oru	31	19	.	.	.
cord-263157-8jin6oru	32	1	Importantly	importantly	RB
cord-263157-8jin6oru	32	2	,	,	,
cord-263157-8jin6oru	32	3	this	this	DT
cord-263157-8jin6oru	32	4	study	study	NN
cord-263157-8jin6oru	32	5	made	make	VBD
cord-263157-8jin6oru	32	6	the	the	DT
cord-263157-8jin6oru	32	7	extraordinary	extraordinary	JJ
cord-263157-8jin6oru	32	8	demonstration	demonstration	NN
cord-263157-8jin6oru	32	9	that	that	DT
cord-263157-8jin6oru	32	10	cell	cell	NN
cord-263157-8jin6oru	32	11	transfection	transfection	NN
cord-263157-8jin6oru	32	12	of	of	IN
cord-263157-8jin6oru	32	13	synthetic	synthetic	JJ
cord-263157-8jin6oru	32	14	21	21	CD
cord-263157-8jin6oru	32	15	base	base	NN
cord-263157-8jin6oru	32	16	pairs	pair	NNS
cord-263157-8jin6oru	32	17	(	(	-LRB-
cord-263157-8jin6oru	32	18	bp	bp	NNP
cord-263157-8jin6oru	32	19	)	)	-RRB-
cord-263157-8jin6oru	32	20	short	short	JJ
cord-263157-8jin6oru	32	21	interfering	interfere	VBG
cord-263157-8jin6oru	32	22	RNA	RNA	NNP
cord-263157-8jin6oru	32	23	(	(	-LRB-
cord-263157-8jin6oru	32	24	siRNA	siRNA	NNP
cord-263157-8jin6oru	32	25	)	)	-RRB-
cord-263157-8jin6oru	32	26	duplexes	duplex	NNS
cord-263157-8jin6oru	32	27	can	can	MD
cord-263157-8jin6oru	32	28	mediate	mediate	VB
cord-263157-8jin6oru	32	29	RNAi	RNAi	NNS
cord-263157-8jin6oru	32	30	in	in	IN
cord-263157-8jin6oru	32	31	a	a	DT
cord-263157-8jin6oru	32	32	sequence	sequence	NN
cord-263157-8jin6oru	32	33	-	-	HYPH
cord-263157-8jin6oru	32	34	specific	specific	JJ
cord-263157-8jin6oru	32	35	manner	manner	NN
cord-263157-8jin6oru	32	36	;	;	:
cord-263157-8jin6oru	32	37	this	this	DT
cord-263157-8jin6oru	32	38	finding	finding	NN
cord-263157-8jin6oru	32	39	enabled	enable	VBD
cord-263157-8jin6oru	32	40	the	the	DT
cord-263157-8jin6oru	32	41	specific	specific	JJ
cord-263157-8jin6oru	32	42	regulation	regulation	NN
cord-263157-8jin6oru	32	43	of	of	IN
cord-263157-8jin6oru	32	44	gene	gene	NN
cord-263157-8jin6oru	32	45	expression	expression	NN
cord-263157-8jin6oru	32	46	in	in	IN
cord-263157-8jin6oru	32	47	a	a	DT
cord-263157-8jin6oru	32	48	variety	variety	NN
cord-263157-8jin6oru	32	49	of	of	IN
cord-263157-8jin6oru	32	50	biological	biological	JJ
cord-263157-8jin6oru	32	51	systems	system	NNS
cord-263157-8jin6oru	32	52	,	,	,
cord-263157-8jin6oru	32	53	including	include	VBG
cord-263157-8jin6oru	32	54	diseased	diseased	JJ
cord-263157-8jin6oru	32	55	cells	cell	NNS
cord-263157-8jin6oru	32	56	.	.	.
cord-263157-8jin6oru	33	1	In	in	IN
cord-263157-8jin6oru	33	2	this	this	DT
cord-263157-8jin6oru	33	3	review	review	NN
cord-263157-8jin6oru	33	4	,	,	,
cord-263157-8jin6oru	33	5	I	-PRON-	PRP
cord-263157-8jin6oru	33	6	will	will	MD
cord-263157-8jin6oru	33	7	focus	focus	VB
cord-263157-8jin6oru	33	8	on	on	IN
cord-263157-8jin6oru	33	9	the	the	DT
cord-263157-8jin6oru	33	10	progress	progress	NN
cord-263157-8jin6oru	33	11	in	in	IN
cord-263157-8jin6oru	33	12	research	research	NN
cord-263157-8jin6oru	33	13	employing	employ	VBG
cord-263157-8jin6oru	33	14	RNAi	RNAi	NNS
cord-263157-8jin6oru	33	15	to	to	TO
cord-263157-8jin6oru	33	16	disrupt	disrupt	VB
cord-263157-8jin6oru	33	17	the	the	DT
cord-263157-8jin6oru	33	18	disease	disease	NN
cord-263157-8jin6oru	33	19	process	process	NN
cord-263157-8jin6oru	33	20	caused	cause	VBN
cord-263157-8jin6oru	33	21	by	by	IN
cord-263157-8jin6oru	33	22	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	33	23	.	.	.
cord-263157-8jin6oru	34	1	Given	give	VBN
cord-263157-8jin6oru	34	2	that	that	IN
cord-263157-8jin6oru	34	3	an	an	DT
cord-263157-8jin6oru	34	4	exogenous	exogenous	JJ
cord-263157-8jin6oru	34	5	RNA	RNA	NNP
cord-263157-8jin6oru	34	6	can	can	MD
cord-263157-8jin6oru	34	7	be	be	VB
cord-263157-8jin6oru	34	8	targeted	target	VBN
cord-263157-8jin6oru	34	9	without	without	IN
cord-263157-8jin6oru	34	10	affecting	affect	VBG
cord-263157-8jin6oru	34	11	cellular	cellular	JJ
cord-263157-8jin6oru	34	12	functions	function	NNS
cord-263157-8jin6oru	34	13	,	,	,
cord-263157-8jin6oru	34	14	one	one	CD
cord-263157-8jin6oru	34	15	of	of	IN
cord-263157-8jin6oru	34	16	the	the	DT
cord-263157-8jin6oru	34	17	most	most	RBS
cord-263157-8jin6oru	34	18	promising	promising	JJ
cord-263157-8jin6oru	34	19	applications	application	NNS
cord-263157-8jin6oru	34	20	of	of	IN
cord-263157-8jin6oru	34	21	RNAi	RNAi	NNS
cord-263157-8jin6oru	34	22	is	be	VBZ
cord-263157-8jin6oru	34	23	in	in	IN
cord-263157-8jin6oru	34	24	the	the	DT
cord-263157-8jin6oru	34	25	treatment	treatment	NN
cord-263157-8jin6oru	34	26	of	of	IN
cord-263157-8jin6oru	34	27	infectious	infectious	JJ
cord-263157-8jin6oru	34	28	diseases	disease	NNS
cord-263157-8jin6oru	34	29	.	.	.
cord-263157-8jin6oru	35	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	35	2	,	,	,
cord-263157-8jin6oru	35	3	there	there	EX
cord-263157-8jin6oru	35	4	are	be	VBP
cord-263157-8jin6oru	35	5	some	some	DT
cord-263157-8jin6oru	35	6	obstacles	obstacle	NNS
cord-263157-8jin6oru	35	7	to	to	IN
cord-263157-8jin6oru	35	8	the	the	DT
cord-263157-8jin6oru	35	9	development	development	NN
cord-263157-8jin6oru	35	10	of	of	IN
cord-263157-8jin6oru	35	11	an	an	DT
cord-263157-8jin6oru	35	12	anti	anti	JJ
cord-263157-8jin6oru	35	13	-	-	JJ
cord-263157-8jin6oru	35	14	HIV-1	hiv-1	JJ
cord-263157-8jin6oru	35	15	RNAibased	rnaibase	VBD
cord-263157-8jin6oru	35	16	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	35	17	agent	agent	NN
cord-263157-8jin6oru	35	18	.	.	.
cord-263157-8jin6oru	36	1	One	one	CD
cord-263157-8jin6oru	36	2	major	major	JJ
cord-263157-8jin6oru	36	3	problem	problem	NN
cord-263157-8jin6oru	36	4	of	of	IN
cord-263157-8jin6oru	36	5	all	all	DT
cord-263157-8jin6oru	36	6	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	36	7	therapies	therapy	NNS
cord-263157-8jin6oru	36	8	is	be	VBZ
cord-263157-8jin6oru	36	9	the	the	DT
cord-263157-8jin6oru	36	10	emergence	emergence	NN
cord-263157-8jin6oru	36	11	of	of	IN
cord-263157-8jin6oru	36	12	resistant	resistant	JJ
cord-263157-8jin6oru	36	13	variants	variant	NNS
cord-263157-8jin6oru	36	14	,	,	,
cord-263157-8jin6oru	36	15	and	and	CC
cord-263157-8jin6oru	36	16	the	the	DT
cord-263157-8jin6oru	36	17	enormous	enormous	JJ
cord-263157-8jin6oru	36	18	genomic	genomic	JJ
cord-263157-8jin6oru	36	19	heterogeneity	heterogeneity	NN
cord-263157-8jin6oru	36	20	of	of	IN
cord-263157-8jin6oru	36	21	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	36	22	may	may	MD
cord-263157-8jin6oru	36	23	hinder	hinder	VB
cord-263157-8jin6oru	36	24	the	the	DT
cord-263157-8jin6oru	36	25	efficacy	efficacy	NN
cord-263157-8jin6oru	36	26	of	of	IN
cord-263157-8jin6oru	36	27	single	single	JJ
cord-263157-8jin6oru	36	28	defined	define	VBN
cord-263157-8jin6oru	36	29	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	36	30	.	.	.
cord-263157-8jin6oru	37	1	Coexpression	Coexpression	NNP
cord-263157-8jin6oru	37	2	of	of	IN
cord-263157-8jin6oru	37	3	multiple	multiple	JJ
cord-263157-8jin6oru	37	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	37	5	could	could	MD
cord-263157-8jin6oru	37	6	reduce	reduce	VB
cord-263157-8jin6oru	37	7	the	the	DT
cord-263157-8jin6oru	37	8	emergence	emergence	NN
cord-263157-8jin6oru	37	9	of	of	IN
cord-263157-8jin6oru	37	10	single	single	JJ
cord-263157-8jin6oru	37	11	-	-	HYPH
cord-263157-8jin6oru	37	12	siRNA	sirna	NN
cord-263157-8jin6oru	37	13	-	-	HYPH
cord-263157-8jin6oru	37	14	resistant	resistant	JJ
cord-263157-8jin6oru	37	15	viruses	virus	NNS
cord-263157-8jin6oru	37	16	,	,	,
cord-263157-8jin6oru	37	17	with	with	IN
cord-263157-8jin6oru	37	18	an	an	DT
cord-263157-8jin6oru	37	19	effect	effect	NN
cord-263157-8jin6oru	37	20	comparable	comparable	JJ
cord-263157-8jin6oru	37	21	to	to	IN
cord-263157-8jin6oru	37	22	that	that	DT
cord-263157-8jin6oru	37	23	achieved	achieve	VBN
cord-263157-8jin6oru	37	24	by	by	IN
cord-263157-8jin6oru	37	25	HAART	HAART	NNP
cord-263157-8jin6oru	37	26	,	,	,
cord-263157-8jin6oru	37	27	which	which	WDT
cord-263157-8jin6oru	37	28	combines	combine	VBZ
cord-263157-8jin6oru	37	29	three	three	CD
cord-263157-8jin6oru	37	30	-	-	HYPH
cord-263157-8jin6oru	37	31	or	or	CC
cord-263157-8jin6oru	37	32	four	four	CD
cord-263157-8jin6oru	37	33	-	-	HYPH
cord-263157-8jin6oru	37	34	anti	anti	NN
cord-263157-8jin6oru	37	35	-	-	JJ
cord-263157-8jin6oru	37	36	HIV-1	hiv-1	JJ
cord-263157-8jin6oru	37	37	drugs	drug	NNS
cord-263157-8jin6oru	37	38	in	in	IN
cord-263157-8jin6oru	37	39	treatment	treatment	NN
cord-263157-8jin6oru	37	40	.	.	.
cord-263157-8jin6oru	38	1	An	an	DT
cord-263157-8jin6oru	38	2	alternative	alternative	JJ
cord-263157-8jin6oru	38	3	strategy	strategy	NN
cord-263157-8jin6oru	38	4	to	to	TO
cord-263157-8jin6oru	38	5	counter	counter	VB
cord-263157-8jin6oru	38	6	the	the	DT
cord-263157-8jin6oru	38	7	possibility	possibility	NN
cord-263157-8jin6oru	38	8	of	of	IN
cord-263157-8jin6oru	38	9	siRNA	sirna	JJ
cord-263157-8jin6oru	38	10	-	-	HYPH
cord-263157-8jin6oru	38	11	resistant	resistant	JJ
cord-263157-8jin6oru	38	12	viruses	virus	NNS
cord-263157-8jin6oru	38	13	would	would	MD
cord-263157-8jin6oru	38	14	be	be	VB
cord-263157-8jin6oru	38	15	to	to	TO
cord-263157-8jin6oru	38	16	target	target	VB
cord-263157-8jin6oru	38	17	transcripts	transcript	NNS
cord-263157-8jin6oru	38	18	of	of	IN
cord-263157-8jin6oru	38	19	cellular	cellular	JJ
cord-263157-8jin6oru	38	20	cofactors	cofactor	NNS
cord-263157-8jin6oru	38	21	essential	essential	JJ
cord-263157-8jin6oru	38	22	for	for	IN
cord-263157-8jin6oru	38	23	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	38	24	infectivity	infectivity	NN
cord-263157-8jin6oru	38	25	or	or	CC
cord-263157-8jin6oru	38	26	replication	replication	NN
cord-263157-8jin6oru	38	27	(	(	-LRB-
cord-263157-8jin6oru	38	28	e.g.	e.g.	RB
cord-263157-8jin6oru	38	29	,	,	,
cord-263157-8jin6oru	38	30	specific	specific	JJ
cord-263157-8jin6oru	38	31	cell	cell	NN
cord-263157-8jin6oru	38	32	surface	surface	NN
cord-263157-8jin6oru	38	33	receptors	receptor	NNS
cord-263157-8jin6oru	38	34	)	)	-RRB-
cord-263157-8jin6oru	38	35	.	.	.
cord-263157-8jin6oru	39	1	The	the	DT
cord-263157-8jin6oru	39	2	side	side	JJ
cord-263157-8jin6oru	39	3	effects	effect	NNS
cord-263157-8jin6oru	39	4	of	of	IN
cord-263157-8jin6oru	39	5	downregulating	downregulate	VBG
cord-263157-8jin6oru	39	6	cellular	cellular	JJ
cord-263157-8jin6oru	39	7	targets	target	NNS
cord-263157-8jin6oru	39	8	over	over	IN
cord-263157-8jin6oru	39	9	the	the	DT
cord-263157-8jin6oru	39	10	long	long	JJ
cord-263157-8jin6oru	39	11	term	term	NN
cord-263157-8jin6oru	39	12	,	,	,
cord-263157-8jin6oru	39	13	however	however	RB
cord-263157-8jin6oru	39	14	,	,	,
cord-263157-8jin6oru	39	15	are	be	VBP
cord-263157-8jin6oru	39	16	currently	currently	RB
cord-263157-8jin6oru	39	17	unknown	unknown	JJ
cord-263157-8jin6oru	39	18	.	.	.
cord-263157-8jin6oru	40	1	Delivery	delivery	NN
cord-263157-8jin6oru	40	2	remains	remain	VBZ
cord-263157-8jin6oru	40	3	a	a	DT
cord-263157-8jin6oru	40	4	major	major	JJ
cord-263157-8jin6oru	40	5	hurdle	hurdle	NN
cord-263157-8jin6oru	40	6	for	for	IN
cord-263157-8jin6oru	40	7	RNAi	RNAi	NNP
cord-263157-8jin6oru	40	8	therapy	therapy	NN
cord-263157-8jin6oru	40	9	,	,	,
cord-263157-8jin6oru	40	10	as	as	IN
cord-263157-8jin6oru	40	11	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	40	12	are	be	VBP
cord-263157-8jin6oru	40	13	unable	unable	JJ
cord-263157-8jin6oru	40	14	to	to	TO
cord-263157-8jin6oru	40	15	cross	cross	VB
cord-263157-8jin6oru	40	16	the	the	DT
cord-263157-8jin6oru	40	17	mammalian	mammalian	JJ
cord-263157-8jin6oru	40	18	cell	cell	NN
cord-263157-8jin6oru	40	19	membrane	membrane	NN
cord-263157-8jin6oru	40	20	without	without	IN
cord-263157-8jin6oru	40	21	aid	aid	NN
cord-263157-8jin6oru	40	22	.	.	.
cord-263157-8jin6oru	41	1	Gene	gene	NN
cord-263157-8jin6oru	41	2	-	-	HYPH
cord-263157-8jin6oru	41	3	therapy	therapy	NN
cord-263157-8jin6oru	41	4	vectors	vector	NNS
cord-263157-8jin6oru	41	5	are	be	VBP
cord-263157-8jin6oru	41	6	capable	capable	JJ
cord-263157-8jin6oru	41	7	of	of	IN
cord-263157-8jin6oru	41	8	stably	stably	RB
cord-263157-8jin6oru	41	9	expressing	express	VBG
cord-263157-8jin6oru	41	10	siRNA	siRNA	NNP
cord-263157-8jin6oru	41	11	precursors	precursor	NNS
cord-263157-8jin6oru	41	12	,	,	,
cord-263157-8jin6oru	41	13	although	although	IN
cord-263157-8jin6oru	41	14	well	well	RB
cord-263157-8jin6oru	41	15	-	-	HYPH
cord-263157-8jin6oru	41	16	documented	document	VBN
cord-263157-8jin6oru	41	17	hazards	hazard	NNS
cord-263157-8jin6oru	41	18	have	have	VBP
cord-263157-8jin6oru	41	19	been	be	VBN
cord-263157-8jin6oru	41	20	observed	observe	VBN
cord-263157-8jin6oru	41	21	after	after	IN
cord-263157-8jin6oru	41	22	the	the	DT
cord-263157-8jin6oru	41	23	introduction	introduction	NN
cord-263157-8jin6oru	41	24	of	of	IN
cord-263157-8jin6oru	41	25	foreign	foreign	JJ
cord-263157-8jin6oru	41	26	vector	vector	NN
cord-263157-8jin6oru	41	27	sequences	sequence	NNS
cord-263157-8jin6oru	41	28	into	into	IN
cord-263157-8jin6oru	41	29	chromosomal	chromosomal	JJ
cord-263157-8jin6oru	41	30	DNA	dna	NN
cord-263157-8jin6oru	41	31	.	.	.
cord-263157-8jin6oru	42	1	Finally	finally	RB
cord-263157-8jin6oru	42	2	,	,	,
cord-263157-8jin6oru	42	3	off	off	IN
cord-263157-8jin6oru	42	4	-	-	HYPH
cord-263157-8jin6oru	42	5	target	target	NN
cord-263157-8jin6oru	42	6	effects	effect	NNS
cord-263157-8jin6oru	42	7	,	,	,
cord-263157-8jin6oru	42	8	such	such	JJ
cord-263157-8jin6oru	42	9	as	as	IN
cord-263157-8jin6oru	42	10	the	the	DT
cord-263157-8jin6oru	42	11	targeting	targeting	NN
cord-263157-8jin6oru	42	12	of	of	IN
cord-263157-8jin6oru	42	13	genes	gene	NNS
cord-263157-8jin6oru	42	14	sharing	share	VBG
cord-263157-8jin6oru	42	15	partial	partial	JJ
cord-263157-8jin6oru	42	16	homology	homology	NN
cord-263157-8jin6oru	42	17	to	to	IN
cord-263157-8jin6oru	42	18	the	the	DT
cord-263157-8jin6oru	42	19	siRNA	siRNA	NNP
cord-263157-8jin6oru	42	20	and	and	CC
cord-263157-8jin6oru	42	21	the	the	DT
cord-263157-8jin6oru	42	22	stimulation	stimulation	NN
cord-263157-8jin6oru	42	23	of	of	IN
cord-263157-8jin6oru	42	24	the	the	DT
cord-263157-8jin6oru	42	25	innate	innate	JJ
cord-263157-8jin6oru	42	26	immune	immune	JJ
cord-263157-8jin6oru	42	27	system	system	NN
cord-263157-8jin6oru	42	28	,	,	,
cord-263157-8jin6oru	42	29	need	need	VBP
cord-263157-8jin6oru	42	30	to	to	TO
cord-263157-8jin6oru	42	31	be	be	VB
cord-263157-8jin6oru	42	32	considered	consider	VBN
cord-263157-8jin6oru	42	33	and	and	CC
cord-263157-8jin6oru	42	34	avoided	avoid	VBN
cord-263157-8jin6oru	42	35	.	.	.
cord-263157-8jin6oru	43	1	Although	although	IN
cord-263157-8jin6oru	43	2	the	the	DT
cord-263157-8jin6oru	43	3	innate	innate	JJ
cord-263157-8jin6oru	43	4	immune	immune	JJ
cord-263157-8jin6oru	43	5	system	system	NN
cord-263157-8jin6oru	43	6	is	be	VBZ
cord-263157-8jin6oru	43	7	efficiently	efficiently	RB
cord-263157-8jin6oru	43	8	triggered	trigger	VBN
cord-263157-8jin6oru	43	9	only	only	RB
cord-263157-8jin6oru	43	10	by	by	IN
cord-263157-8jin6oru	43	11	dsRNAs	dsRNAs	NNP
cord-263157-8jin6oru	43	12	more	more	JJR
cord-263157-8jin6oru	43	13	than	than	IN
cord-263157-8jin6oru	43	14	30	30	CD
cord-263157-8jin6oru	43	15	bp	bp	NN
cord-263157-8jin6oru	43	16	,	,	,
cord-263157-8jin6oru	43	17	high	high	JJ
cord-263157-8jin6oru	43	18	concentrations	concentration	NNS
cord-263157-8jin6oru	43	19	of	of	IN
cord-263157-8jin6oru	43	20	smaller	small	JJR
cord-263157-8jin6oru	43	21	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	43	22	may	may	MD
cord-263157-8jin6oru	43	23	be	be	VB
cord-263157-8jin6oru	43	24	able	able	JJ
cord-263157-8jin6oru	43	25	to	to	TO
cord-263157-8jin6oru	43	26	activate	activate	VB
cord-263157-8jin6oru	43	27	this	this	DT
cord-263157-8jin6oru	43	28	pathway	pathway	NN
cord-263157-8jin6oru	43	29	.	.	.
cord-263157-8jin6oru	44	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	44	2	,	,	,
cord-263157-8jin6oru	44	3	there	there	EX
cord-263157-8jin6oru	44	4	is	be	VBZ
cord-263157-8jin6oru	44	5	no	no	DT
cord-263157-8jin6oru	44	6	evidence	evidence	NN
cord-263157-8jin6oru	44	7	that	that	IN
cord-263157-8jin6oru	44	8	the	the	DT
cord-263157-8jin6oru	44	9	activation	activation	NN
cord-263157-8jin6oru	44	10	of	of	IN
cord-263157-8jin6oru	44	11	the	the	DT
cord-263157-8jin6oru	44	12	innate	innate	JJ
cord-263157-8jin6oru	44	13	immune	immune	JJ
cord-263157-8jin6oru	44	14	system	system	NN
cord-263157-8jin6oru	44	15	influences	influence	VBZ
cord-263157-8jin6oru	44	16	the	the	DT
cord-263157-8jin6oru	44	17	degree	degree	NN
cord-263157-8jin6oru	44	18	or	or	CC
cord-263157-8jin6oru	44	19	specificity	specificity	NN
cord-263157-8jin6oru	44	20	of	of	IN
cord-263157-8jin6oru	44	21	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	44	22	.	.	.
cord-263157-8jin6oru	45	1	The	the	DT
cord-263157-8jin6oru	45	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	45	3	life	life	NN
cord-263157-8jin6oru	45	4	cycle	cycle	NN
cord-263157-8jin6oru	45	5	begins	begin	VBZ
cord-263157-8jin6oru	45	6	by	by	IN
cord-263157-8jin6oru	45	7	viral	viral	JJ
cord-263157-8jin6oru	45	8	binding	binding	NN
cord-263157-8jin6oru	45	9	via	via	IN
cord-263157-8jin6oru	45	10	the	the	DT
cord-263157-8jin6oru	45	11	viral	viral	JJ
cord-263157-8jin6oru	45	12	envelope	envelope	NN
cord-263157-8jin6oru	45	13	to	to	IN
cord-263157-8jin6oru	45	14	the	the	DT
cord-263157-8jin6oru	45	15	cellular	cellular	JJ
cord-263157-8jin6oru	45	16	receptor	receptor	NN
cord-263157-8jin6oru	45	17	CD4	CD4	NNP
cord-263157-8jin6oru	45	18	in	in	IN
cord-263157-8jin6oru	45	19	conjunction	conjunction	NN
cord-263157-8jin6oru	45	20	with	with	IN
cord-263157-8jin6oru	45	21	a	a	DT
cord-263157-8jin6oru	45	22	coreceptor	coreceptor	NN
cord-263157-8jin6oru	45	23	,	,	,
cord-263157-8jin6oru	45	24	either	either	CC
cord-263157-8jin6oru	45	25	CXCR4	CXCR4	NNS
cord-263157-8jin6oru	45	26	in	in	IN
cord-263157-8jin6oru	45	27	the	the	DT
cord-263157-8jin6oru	45	28	case	case	NN
cord-263157-8jin6oru	45	29	of	of	IN
cord-263157-8jin6oru	45	30	T	t	NN
cord-263157-8jin6oru	45	31	-	-	HYPH
cord-263157-8jin6oru	45	32	cell	cell	NN
cord-263157-8jin6oru	45	33	-	-	HYPH
cord-263157-8jin6oru	45	34	tropic	tropic	NN
cord-263157-8jin6oru	45	35	virus	virus	NN
cord-263157-8jin6oru	45	36	or	or	CC
cord-263157-8jin6oru	45	37	CCR5	CCR5	NNP
cord-263157-8jin6oru	45	38	for	for	IN
cord-263157-8jin6oru	45	39	macrophage	macrophage	NN
cord-263157-8jin6oru	45	40	-	-	HYPH
cord-263157-8jin6oru	45	41	tropic	tropic	NN
cord-263157-8jin6oru	45	42	virus	virus	NN
cord-263157-8jin6oru	45	43	(	(	-LRB-
cord-263157-8jin6oru	45	44	Fig	Fig	NNP
cord-263157-8jin6oru	45	45	.	.	.
cord-263157-8jin6oru	45	46	17.1	17.1	CD
cord-263157-8jin6oru	45	47	)	)	-RRB-
cord-263157-8jin6oru	45	48	.	.	.
cord-263157-8jin6oru	46	1	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	46	2	infects	infect	VBZ
cord-263157-8jin6oru	46	3	cells	cell	NNS
cord-263157-8jin6oru	46	4	of	of	IN
cord-263157-8jin6oru	46	5	the	the	DT
cord-263157-8jin6oru	46	6	immune	immune	JJ
cord-263157-8jin6oru	46	7	system	system	NN
cord-263157-8jin6oru	46	8	,	,	,
cord-263157-8jin6oru	46	9	specifically	specifically	RB
cord-263157-8jin6oru	46	10	CD4	CD4	NNP
cord-263157-8jin6oru	46	11	+	+	CC
cord-263157-8jin6oru	46	12	cells	cell	NNS
cord-263157-8jin6oru	46	13	,	,	,
cord-263157-8jin6oru	46	14	which	which	WDT
cord-263157-8jin6oru	46	15	include	include	VBP
cord-263157-8jin6oru	46	16	T	t	NN
cord-263157-8jin6oru	46	17	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	46	18	,	,	,
cord-263157-8jin6oru	46	19	monocytes	monocyte	NNS
cord-263157-8jin6oru	46	20	and	and	CC
cord-263157-8jin6oru	46	21	macrophages	macrophage	NNS
cord-263157-8jin6oru	46	22	.	.	.
cord-263157-8jin6oru	47	1	As	as	IN
cord-263157-8jin6oru	47	2	a	a	DT
cord-263157-8jin6oru	47	3	result	result	NN
cord-263157-8jin6oru	47	4	,	,	,
cord-263157-8jin6oru	47	5	in	in	IN
cord-263157-8jin6oru	47	6	the	the	DT
cord-263157-8jin6oru	47	7	absence	absence	NN
cord-263157-8jin6oru	47	8	of	of	IN
cord-263157-8jin6oru	47	9	effective	effective	JJ
cord-263157-8jin6oru	47	10	vaccination	vaccination	NN
cord-263157-8jin6oru	47	11	or	or	CC
cord-263157-8jin6oru	47	12	therapy	therapy	NN
cord-263157-8jin6oru	47	13	,	,	,
cord-263157-8jin6oru	47	14	a	a	DT
cord-263157-8jin6oru	47	15	slow	slow	JJ
cord-263157-8jin6oru	47	16	and	and	CC
cord-263157-8jin6oru	47	17	continued	continued	JJ
cord-263157-8jin6oru	47	18	depletion	depletion	NN
cord-263157-8jin6oru	47	19	2	2	CD
cord-263157-8jin6oru	47	20	.	.	.
cord-263157-8jin6oru	48	1	Targeting	target	VBG
cord-263157-8jin6oru	48	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	48	3	Replication	Replication	NNP
cord-263157-8jin6oru	48	4	by	by	IN
cord-263157-8jin6oru	48	5	RNAi	RNAi	NNP
cord-263157-8jin6oru	48	6	Fig	Fig	NNP
cord-263157-8jin6oru	48	7	of	of	IN
cord-263157-8jin6oru	48	8	CD4	CD4	NNP
cord-263157-8jin6oru	48	9	+	+	CC
cord-263157-8jin6oru	48	10	T	t	NN
cord-263157-8jin6oru	48	11	cells	cell	NNS
cord-263157-8jin6oru	48	12	ensues	ensue	VBZ
cord-263157-8jin6oru	48	13	and	and	CC
cord-263157-8jin6oru	48	14	there	there	EX
cord-263157-8jin6oru	48	15	is	be	VBZ
cord-263157-8jin6oru	48	16	a	a	DT
cord-263157-8jin6oru	48	17	progression	progression	NN
cord-263157-8jin6oru	48	18	towards	towards	IN
cord-263157-8jin6oru	48	19	AIDS	AIDS	NNP
cord-263157-8jin6oru	48	20	.	.	.
cord-263157-8jin6oru	49	1	Fusion	fusion	NN
cord-263157-8jin6oru	49	2	of	of	IN
cord-263157-8jin6oru	49	3	the	the	DT
cord-263157-8jin6oru	49	4	viral	viral	JJ
cord-263157-8jin6oru	49	5	and	and	CC
cord-263157-8jin6oru	49	6	cellular	cellular	JJ
cord-263157-8jin6oru	49	7	membranes	membrane	NNS
cord-263157-8jin6oru	49	8	provides	provide	VBZ
cord-263157-8jin6oru	49	9	the	the	DT
cord-263157-8jin6oru	49	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	49	11	genome	genome	NN
cord-263157-8jin6oru	49	12	,	,	,
cord-263157-8jin6oru	49	13	two	two	CD
cord-263157-8jin6oru	49	14	RNA	RNA	NNP
cord-263157-8jin6oru	49	15	molecules	molecule	NNS
cord-263157-8jin6oru	49	16	of	of	IN
cord-263157-8jin6oru	49	17	positive	positive	JJ
cord-263157-8jin6oru	49	18	polarity	polarity	NN
cord-263157-8jin6oru	49	19	,	,	,
cord-263157-8jin6oru	49	20	access	access	NN
cord-263157-8jin6oru	49	21	to	to	IN
cord-263157-8jin6oru	49	22	the	the	DT
cord-263157-8jin6oru	49	23	interior	interior	NN
cord-263157-8jin6oru	49	24	of	of	IN
cord-263157-8jin6oru	49	25	the	the	DT
cord-263157-8jin6oru	49	26	cell	cell	NN
cord-263157-8jin6oru	49	27	.	.	.
cord-263157-8jin6oru	50	1	The	the	DT
cord-263157-8jin6oru	50	2	genomic	genomic	JJ
cord-263157-8jin6oru	50	3	viral	viral	JJ
cord-263157-8jin6oru	50	4	RNA	RNA	NNP
cord-263157-8jin6oru	50	5	is	be	VBZ
cord-263157-8jin6oru	50	6	then	then	RB
cord-263157-8jin6oru	50	7	converted	convert	VBN
cord-263157-8jin6oru	50	8	into	into	IN
cord-263157-8jin6oru	50	9	double	double	RB
cord-263157-8jin6oru	50	10	-	-	HYPH
cord-263157-8jin6oru	50	11	stranded	strand	VBN
cord-263157-8jin6oru	50	12	DNA	dna	NN
cord-263157-8jin6oru	50	13	by	by	IN
cord-263157-8jin6oru	50	14	the	the	DT
cord-263157-8jin6oru	50	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	50	16	RT	RT	NNP
cord-263157-8jin6oru	50	17	(	(	-LRB-
cord-263157-8jin6oru	50	18	Fig	Fig	NNP
cord-263157-8jin6oru	50	19	.	.	.
cord-263157-8jin6oru	50	20	17.1	17.1	CD
cord-263157-8jin6oru	50	21	)	)	-RRB-
cord-263157-8jin6oru	50	22	.	.	.
cord-263157-8jin6oru	51	1	The	the	DT
cord-263157-8jin6oru	51	2	viral	viral	JJ
cord-263157-8jin6oru	51	3	DNA	dna	NN
cord-263157-8jin6oru	51	4	forms	form	NNS
cord-263157-8jin6oru	51	5	a	a	DT
cord-263157-8jin6oru	51	6	pre	pre	JJ
cord-263157-8jin6oru	51	7	-	-	JJ
cord-263157-8jin6oru	51	8	integration	integration	JJ
cord-263157-8jin6oru	51	9	complex	complex	NN
cord-263157-8jin6oru	51	10	along	along	IN
cord-263157-8jin6oru	51	11	with	with	IN
cord-263157-8jin6oru	51	12	the	the	DT
cord-263157-8jin6oru	51	13	viral	viral	JJ
cord-263157-8jin6oru	51	14	integrase	integrase	NN
cord-263157-8jin6oru	51	15	,	,	,
cord-263157-8jin6oru	51	16	which	which	WDT
cord-263157-8jin6oru	51	17	is	be	VBZ
cord-263157-8jin6oru	51	18	then	then	RB
cord-263157-8jin6oru	51	19	transported	transport	VBN
cord-263157-8jin6oru	51	20	to	to	IN
cord-263157-8jin6oru	51	21	the	the	DT
cord-263157-8jin6oru	51	22	nucleus	nucleus	NN
cord-263157-8jin6oru	51	23	where	where	WRB
cord-263157-8jin6oru	51	24	the	the	DT
cord-263157-8jin6oru	51	25	DNA	DNA	NNP
cord-263157-8jin6oru	51	26	is	be	VBZ
cord-263157-8jin6oru	51	27	integrated	integrate	VBN
cord-263157-8jin6oru	51	28	into	into	IN
cord-263157-8jin6oru	51	29	the	the	DT
cord-263157-8jin6oru	51	30	host	host	NN
cord-263157-8jin6oru	51	31	genome	genome	NN
cord-263157-8jin6oru	51	32	as	as	IN
cord-263157-8jin6oru	51	33	a	a	DT
cord-263157-8jin6oru	51	34	provirus	provirus	NN
cord-263157-8jin6oru	51	35	.	.	.
cord-263157-8jin6oru	52	1	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	52	2	replication	replication	NN
cord-263157-8jin6oru	52	3	can	can	MD
cord-263157-8jin6oru	52	4	be	be	VB
cord-263157-8jin6oru	52	5	divided	divide	VBN
cord-263157-8jin6oru	52	6	into	into	IN
cord-263157-8jin6oru	52	7	early	early	JJ
cord-263157-8jin6oru	52	8	and	and	CC
cord-263157-8jin6oru	52	9	late	late	JJ
cord-263157-8jin6oru	52	10	phases	phase	NNS
cord-263157-8jin6oru	52	11	.	.	.
cord-263157-8jin6oru	53	1	During	during	IN
cord-263157-8jin6oru	53	2	the	the	DT
cord-263157-8jin6oru	53	3	early	early	JJ
cord-263157-8jin6oru	53	4	phase	phase	NN
cord-263157-8jin6oru	53	5	,	,	,
cord-263157-8jin6oru	53	6	spliced	splice	VBN
cord-263157-8jin6oru	53	7	transcripts	transcript	NNS
cord-263157-8jin6oru	53	8	encoding	encode	VBG
cord-263157-8jin6oru	53	9	two	two	CD
cord-263157-8jin6oru	53	10	essential	essential	JJ
cord-263157-8jin6oru	53	11	proteins	protein	NNS
cord-263157-8jin6oru	53	12	,	,	,
cord-263157-8jin6oru	53	13	Tat	Tat	NNP
cord-263157-8jin6oru	53	14	and	and	CC
cord-263157-8jin6oru	53	15	Rev	Rev	NNP
cord-263157-8jin6oru	53	16	,	,	,
cord-263157-8jin6oru	53	17	are	be	VBP
cord-263157-8jin6oru	53	18	synthesized	synthesize	VBN
cord-263157-8jin6oru	53	19	.	.	.
cord-263157-8jin6oru	54	1	Tat	Tat	NNP
cord-263157-8jin6oru	54	2	further	further	RB
cord-263157-8jin6oru	54	3	activates	activate	VBZ
cord-263157-8jin6oru	54	4	viral	viral	JJ
cord-263157-8jin6oru	54	5	transcription	transcription	NN
cord-263157-8jin6oru	54	6	,	,	,
cord-263157-8jin6oru	54	7	whereas	whereas	IN
cord-263157-8jin6oru	54	8	Rev	Rev	NNP
cord-263157-8jin6oru	54	9	interacts	interact	VBZ
cord-263157-8jin6oru	54	10	with	with	IN
cord-263157-8jin6oru	54	11	Rev	Rev	NNP
cord-263157-8jin6oru	54	12	-	-	HYPH
cord-263157-8jin6oru	54	13	responsive	responsive	JJ
cord-263157-8jin6oru	54	14	elements	element	NNS
cord-263157-8jin6oru	54	15	(	(	-LRB-
cord-263157-8jin6oru	54	16	RRE	RRE	NNP
cord-263157-8jin6oru	54	17	)	)	-RRB-
cord-263157-8jin6oru	54	18	to	to	TO
cord-263157-8jin6oru	54	19	facilitate	facilitate	VB
cord-263157-8jin6oru	54	20	nuclear	nuclear	JJ
cord-263157-8jin6oru	54	21	export	export	NN
cord-263157-8jin6oru	54	22	of	of	IN
cord-263157-8jin6oru	54	23	unspliced	unspliced	JJ
cord-263157-8jin6oru	54	24	and	and	CC
cord-263157-8jin6oru	54	25	singly	singly	RB
cord-263157-8jin6oru	54	26	spliced	splice	VBN
cord-263157-8jin6oru	54	27	mRNAs	mRNAs	''
cord-263157-8jin6oru	54	28	.	.	.
cord-263157-8jin6oru	55	1	These	these	DT
cord-263157-8jin6oru	55	2	late	late	JJ
cord-263157-8jin6oru	55	3	mRNAs	mRNAs	NNPS
cord-263157-8jin6oru	55	4	encode	encode	VBP
cord-263157-8jin6oru	55	5	the	the	DT
cord-263157-8jin6oru	55	6	remaining	remain	VBG
cord-263157-8jin6oru	55	7	viral	viral	JJ
cord-263157-8jin6oru	55	8	proteins	protein	NNS
cord-263157-8jin6oru	55	9	,	,	,
cord-263157-8jin6oru	55	10	including	include	VBG
cord-263157-8jin6oru	55	11	Gag	gag	NN
cord-263157-8jin6oru	55	12	,	,	,
cord-263157-8jin6oru	55	13	Pol	Pol	NNP
cord-263157-8jin6oru	55	14	and	and	CC
cord-263157-8jin6oru	55	15	Env	Env	NNP
cord-263157-8jin6oru	55	16	,	,	,
cord-263157-8jin6oru	55	17	that	that	WDT
cord-263157-8jin6oru	55	18	assemble	assemble	VBP
cord-263157-8jin6oru	55	19	at	at	IN
cord-263157-8jin6oru	55	20	the	the	DT
cord-263157-8jin6oru	55	21	cell	cell	NN
cord-263157-8jin6oru	55	22	surface	surface	NN
cord-263157-8jin6oru	55	23	together	together	RB
cord-263157-8jin6oru	55	24	with	with	IN
cord-263157-8jin6oru	55	25	the	the	DT
cord-263157-8jin6oru	55	26	viral	viral	JJ
cord-263157-8jin6oru	55	27	genome	genome	NN
cord-263157-8jin6oru	55	28	to	to	TO
cord-263157-8jin6oru	55	29	form	form	VB
cord-263157-8jin6oru	55	30	virions	virion	NNS
cord-263157-8jin6oru	55	31	that	that	WDT
cord-263157-8jin6oru	55	32	are	be	VBP
cord-263157-8jin6oru	55	33	released	release	VBN
cord-263157-8jin6oru	55	34	from	from	IN
cord-263157-8jin6oru	55	35	the	the	DT
cord-263157-8jin6oru	55	36	cell	cell	NN
cord-263157-8jin6oru	55	37	by	by	IN
cord-263157-8jin6oru	55	38	budding	bud	VBG
cord-263157-8jin6oru	55	39	.	.	.
cord-263157-8jin6oru	56	1	The	the	DT
cord-263157-8jin6oru	56	2	viral	viral	JJ
cord-263157-8jin6oru	56	3	protease	protease	NN
cord-263157-8jin6oru	56	4	continues	continue	VBZ
cord-263157-8jin6oru	56	5	to	to	TO
cord-263157-8jin6oru	56	6	process	process	VB
cord-263157-8jin6oru	56	7	the	the	DT
cord-263157-8jin6oru	56	8	viral	viral	JJ
cord-263157-8jin6oru	56	9	polyproteins	polyprotein	NNS
cord-263157-8jin6oru	56	10	into	into	IN
cord-263157-8jin6oru	56	11	their	-PRON-	PRP$
cord-263157-8jin6oru	56	12	mature	mature	JJ
cord-263157-8jin6oru	56	13	form	form	NN
cord-263157-8jin6oru	56	14	,	,	,
cord-263157-8jin6oru	56	15	condensing	condense	VBG
cord-263157-8jin6oru	56	16	the	the	DT
cord-263157-8jin6oru	56	17	viral	viral	JJ
cord-263157-8jin6oru	56	18	genomic	genomic	JJ
cord-263157-8jin6oru	56	19	RNA	RNA	NNP
cord-263157-8jin6oru	56	20	core	core	NN
cord-263157-8jin6oru	56	21	and	and	CC
cord-263157-8jin6oru	56	22	yielding	yield	VBG
cord-263157-8jin6oru	56	23	infectious	infectious	JJ
cord-263157-8jin6oru	56	24	particles	particle	NNS
cord-263157-8jin6oru	56	25	(	(	-LRB-
cord-263157-8jin6oru	56	26	Fig	Fig	NNP
cord-263157-8jin6oru	56	27	.	.	.
cord-263157-8jin6oru	56	28	17.1	17.1	CD
cord-263157-8jin6oru	56	29	)	)	-RRB-
cord-263157-8jin6oru	56	30	.	.	.
cord-263157-8jin6oru	57	1	Soon	soon	RB
cord-263157-8jin6oru	57	2	after	after	IN
cord-263157-8jin6oru	57	3	the	the	DT
cord-263157-8jin6oru	57	4	demonstration	demonstration	NN
cord-263157-8jin6oru	57	5	that	that	WDT
cord-263157-8jin6oru	57	6	synthetic	synthetic	JJ
cord-263157-8jin6oru	57	7	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	57	8	were	be	VBD
cord-263157-8jin6oru	57	9	able	able	JJ
cord-263157-8jin6oru	57	10	to	to	TO
cord-263157-8jin6oru	57	11	induce	induce	VB
cord-263157-8jin6oru	57	12	the	the	DT
cord-263157-8jin6oru	57	13	RNAi	RNAi	NNP
cord-263157-8jin6oru	57	14	mechanism	mechanism	NN
cord-263157-8jin6oru	57	15	in	in	IN
cord-263157-8jin6oru	57	16	mammalian	mammalian	JJ
cord-263157-8jin6oru	57	17	cells	cell	NNS
cord-263157-8jin6oru	57	18	(	(	-LRB-
cord-263157-8jin6oru	57	19	15	15	CD
cord-263157-8jin6oru	57	20	)	)	-RRB-
cord-263157-8jin6oru	57	21	,	,	,
cord-263157-8jin6oru	57	22	several	several	JJ
cord-263157-8jin6oru	57	23	studies	study	NNS
cord-263157-8jin6oru	57	24	reported	report	VBD
cord-263157-8jin6oru	57	25	that	that	IN
cord-263157-8jin6oru	57	26	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	57	27	gene	gene	NN
cord-263157-8jin6oru	57	28	expression	expression	NN
cord-263157-8jin6oru	57	29	and	and	CC
cord-263157-8jin6oru	57	30	replication	replication	NN
cord-263157-8jin6oru	57	31	ex	ex	FW
cord-263157-8jin6oru	57	32	vivo	vivo	NN
cord-263157-8jin6oru	57	33	could	could	MD
cord-263157-8jin6oru	57	34	be	be	VB
cord-263157-8jin6oru	57	35	inhibited	inhibit	VBN
cord-263157-8jin6oru	57	36	by	by	IN
cord-263157-8jin6oru	57	37	virus	virus	NN
cord-263157-8jin6oru	57	38	-	-	HYPH
cord-263157-8jin6oru	57	39	specific	specific	JJ
cord-263157-8jin6oru	57	40	synthetic	synthetic	JJ
cord-263157-8jin6oru	57	41	siR	siR	NNP
cord-263157-8jin6oru	57	42	-	-	HYPH
cord-263157-8jin6oru	57	43	NAs	NAs	NNPS
cord-263157-8jin6oru	57	44	(	(	-LRB-
cord-263157-8jin6oru	57	45	16	16	CD
cord-263157-8jin6oru	57	46	-	-	SYM
cord-263157-8jin6oru	57	47	22	22	CD
cord-263157-8jin6oru	57	48	)	)	-RRB-
cord-263157-8jin6oru	57	49	or	or	CC
cord-263157-8jin6oru	57	50	expressed	express	VBD
cord-263157-8jin6oru	57	51	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	57	52	(	(	-LRB-
cord-263157-8jin6oru	57	53	16	16	CD
cord-263157-8jin6oru	57	54	,	,	,
cord-263157-8jin6oru	57	55	18	18	CD
cord-263157-8jin6oru	57	56	)	)	-RRB-
cord-263157-8jin6oru	57	57	that	that	WDT
cord-263157-8jin6oru	57	58	were	be	VBD
cord-263157-8jin6oru	57	59	targeted	target	VBN
cord-263157-8jin6oru	57	60	to	to	IN
cord-263157-8jin6oru	57	61	early	early	JJ
cord-263157-8jin6oru	57	62	or	or	CC
cord-263157-8jin6oru	57	63	late	late	JJ
cord-263157-8jin6oru	57	64	phases	phase	NNS
cord-263157-8jin6oru	57	65	of	of	IN
cord-263157-8jin6oru	57	66	virus	virus	NN
cord-263157-8jin6oru	57	67	replication	replication	NN
cord-263157-8jin6oru	57	68	.	.	.
cord-263157-8jin6oru	58	1	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	58	2	against	against	IN
cord-263157-8jin6oru	58	3	several	several	JJ
cord-263157-8jin6oru	58	4	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	58	5	components	component	NNS
cord-263157-8jin6oru	58	6	(	(	-LRB-
cord-263157-8jin6oru	58	7	Gag	Gag	NNP
cord-263157-8jin6oru	58	8	,	,	,
cord-263157-8jin6oru	58	9	Env	Env	NNP
cord-263157-8jin6oru	58	10	,	,	,
cord-263157-8jin6oru	58	11	Pol	Pol	NNP
cord-263157-8jin6oru	58	12	,	,	,
cord-263157-8jin6oru	58	13	the	the	DT
cord-263157-8jin6oru	58	14	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	58	15	long	long	JJ
cord-263157-8jin6oru	58	16	terminal	terminal	NN
cord-263157-8jin6oru	58	17	repeat	repeat	NN
cord-263157-8jin6oru	58	18	,	,	,
cord-263157-8jin6oru	58	19	Vif	Vif	NNP
cord-263157-8jin6oru	58	20	,	,	,
cord-263157-8jin6oru	58	21	Nef	Nef	NNP
cord-263157-8jin6oru	58	22	,	,	,
cord-263157-8jin6oru	58	23	Tat	Tat	NNP
cord-263157-8jin6oru	58	24	and	and	CC
cord-263157-8jin6oru	58	25	Rev	Rev	NNP
cord-263157-8jin6oru	58	26	)	)	-RRB-
cord-263157-8jin6oru	58	27	were	be	VBD
cord-263157-8jin6oru	58	28	confirmed	confirm	VBN
cord-263157-8jin6oru	58	29	to	to	TO
cord-263157-8jin6oru	58	30	effectively	effectively	RB
cord-263157-8jin6oru	58	31	target	target	VB
cord-263157-8jin6oru	58	32	these	these	DT
cord-263157-8jin6oru	58	33	genes	gene	NNS
cord-263157-8jin6oru	58	34	.	.	.
cord-263157-8jin6oru	59	1	Moreover	moreover	RB
cord-263157-8jin6oru	59	2	,	,	,
cord-263157-8jin6oru	59	3	CD4	CD4	NNP
cord-263157-8jin6oru	59	4	+	+	CC
cord-263157-8jin6oru	59	5	T	t	NN
cord-263157-8jin6oru	59	6	cells	cell	NNS
cord-263157-8jin6oru	59	7	(	(	-LRB-
cord-263157-8jin6oru	59	8	18	18	CD
cord-263157-8jin6oru	59	9	,	,	,
cord-263157-8jin6oru	59	10	23	23	CD
cord-263157-8jin6oru	59	11	)	)	-RRB-
cord-263157-8jin6oru	59	12	and	and	CC
cord-263157-8jin6oru	59	13	macrophages	macrophage	NNS
cord-263157-8jin6oru	59	14	(	(	-LRB-
cord-263157-8jin6oru	59	15	24	24	CD
cord-263157-8jin6oru	59	16	,	,	,
cord-263157-8jin6oru	59	17	25	25	CD
cord-263157-8jin6oru	59	18	)	)	-RRB-
cord-263157-8jin6oru	59	19	,	,	,
cord-263157-8jin6oru	59	20	which	which	WDT
cord-263157-8jin6oru	59	21	are	be	VBP
cord-263157-8jin6oru	59	22	the	the	DT
cord-263157-8jin6oru	59	23	natural	natural	JJ
cord-263157-8jin6oru	59	24	targets	target	NNS
cord-263157-8jin6oru	59	25	for	for	IN
cord-263157-8jin6oru	59	26	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	59	27	infection	infection	NN
cord-263157-8jin6oru	59	28	,	,	,
cord-263157-8jin6oru	59	29	were	be	VBD
cord-263157-8jin6oru	59	30	also	also	RB
cord-263157-8jin6oru	59	31	found	find	VBN
cord-263157-8jin6oru	59	32	to	to	TO
cord-263157-8jin6oru	59	33	be	be	VB
cord-263157-8jin6oru	59	34	functional	functional	JJ
cord-263157-8jin6oru	59	35	for	for	IN
cord-263157-8jin6oru	59	36	RNAi	RNAi	NNS
cord-263157-8jin6oru	59	37	.	.	.
cord-263157-8jin6oru	60	1	However	however	RB
cord-263157-8jin6oru	60	2	,	,	,
cord-263157-8jin6oru	60	3	an	an	DT
cord-263157-8jin6oru	60	4	important	important	JJ
cord-263157-8jin6oru	60	5	question	question	NN
cord-263157-8jin6oru	60	6	arose	arise	VBD
cord-263157-8jin6oru	60	7	from	from	IN
cord-263157-8jin6oru	60	8	these	these	DT
cord-263157-8jin6oru	60	9	pioneer	pioneer	NN
cord-263157-8jin6oru	60	10	studies	study	NNS
cord-263157-8jin6oru	60	11	:	:	:
cord-263157-8jin6oru	60	12	is	be	VBZ
cord-263157-8jin6oru	60	13	the	the	DT
cord-263157-8jin6oru	60	14	virion	virion	NN
cord-263157-8jin6oru	60	15	-	-	HYPH
cord-263157-8jin6oru	60	16	associated	associate	VBN
cord-263157-8jin6oru	60	17	incoming	incoming	JJ
cord-263157-8jin6oru	60	18	genomic	genomic	JJ
cord-263157-8jin6oru	60	19	viral	viral	JJ
cord-263157-8jin6oru	60	20	RNA	RNA	NNP
cord-263157-8jin6oru	60	21	targeted	target	VBN
cord-263157-8jin6oru	60	22	by	by	IN
cord-263157-8jin6oru	60	23	RNAi	RNAi	NNS
cord-263157-8jin6oru	60	24	?	?	.
cord-263157-8jin6oru	61	1	Since	since	IN
cord-263157-8jin6oru	61	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	61	3	is	be	VBZ
cord-263157-8jin6oru	61	4	capable	capable	JJ
cord-263157-8jin6oru	61	5	of	of	IN
cord-263157-8jin6oru	61	6	being	be	VBG
cord-263157-8jin6oru	61	7	integrated	integrate	VBN
cord-263157-8jin6oru	61	8	in	in	IN
cord-263157-8jin6oru	61	9	the	the	DT
cord-263157-8jin6oru	61	10	host	host	NN
cord-263157-8jin6oru	61	11	genome	genome	NN
cord-263157-8jin6oru	61	12	as	as	RB
cord-263157-8jin6oru	61	13	well	well	RB
cord-263157-8jin6oru	61	14	as	as	IN
cord-263157-8jin6oru	61	15	infecting	infect	VBG
cord-263157-8jin6oru	61	16	resting	rest	VBG
cord-263157-8jin6oru	61	17	CD4	CD4	NNP
cord-263157-8jin6oru	61	18	+	+	CC
cord-263157-8jin6oru	61	19	T	t	NN
cord-263157-8jin6oru	61	20	cells	cell	NNS
cord-263157-8jin6oru	61	21	to	to	TO
cord-263157-8jin6oru	61	22	create	create	VB
cord-263157-8jin6oru	61	23	a	a	DT
cord-263157-8jin6oru	61	24	pool	pool	NN
cord-263157-8jin6oru	61	25	of	of	IN
cord-263157-8jin6oru	61	26	latently	latently	RB
cord-263157-8jin6oru	61	27	infected	infect	VBN
cord-263157-8jin6oru	61	28	cells	cell	NNS
cord-263157-8jin6oru	61	29	(	(	-LRB-
cord-263157-8jin6oru	61	30	4	4	CD
cord-263157-8jin6oru	61	31	)	)	-RRB-
cord-263157-8jin6oru	61	32	,	,	,
cord-263157-8jin6oru	61	33	the	the	DT
cord-263157-8jin6oru	61	34	capacity	capacity	NN
cord-263157-8jin6oru	61	35	to	to	TO
cord-263157-8jin6oru	61	36	target	target	VB
cord-263157-8jin6oru	61	37	incoming	incoming	JJ
cord-263157-8jin6oru	61	38	viral	viral	JJ
cord-263157-8jin6oru	61	39	RNA	RNA	NNP
cord-263157-8jin6oru	61	40	by	by	IN
cord-263157-8jin6oru	61	41	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	61	42	has	have	VBZ
cord-263157-8jin6oru	61	43	important	important	JJ
cord-263157-8jin6oru	61	44	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	61	45	implications	implication	NNS
cord-263157-8jin6oru	61	46	(	(	-LRB-
cord-263157-8jin6oru	61	47	Fig	fig	NN
cord-263157-8jin6oru	61	48	.	.	.
cord-263157-8jin6oru	61	49	17.1	17.1	CD
cord-263157-8jin6oru	61	50	)	)	-RRB-
cord-263157-8jin6oru	61	51	(	(	-LRB-
cord-263157-8jin6oru	61	52	26	26	CD
cord-263157-8jin6oru	61	53	)	)	-RRB-
cord-263157-8jin6oru	61	54	.	.	.
cord-263157-8jin6oru	62	1	If	if	IN
cord-263157-8jin6oru	62	2	it	-PRON-	PRP
cord-263157-8jin6oru	62	3	is	be	VBZ
cord-263157-8jin6oru	62	4	not	not	RB
cord-263157-8jin6oru	62	5	possible	possible	JJ
cord-263157-8jin6oru	62	6	to	to	TO
cord-263157-8jin6oru	62	7	target	target	VB
cord-263157-8jin6oru	62	8	incoming	incoming	JJ
cord-263157-8jin6oru	62	9	viral	viral	JJ
cord-263157-8jin6oru	62	10	genomic	genomic	JJ
cord-263157-8jin6oru	62	11	RNA	RNA	NNP
cord-263157-8jin6oru	62	12	,	,	,
cord-263157-8jin6oru	62	13	it	-PRON-	PRP
cord-263157-8jin6oru	62	14	will	will	MD
cord-263157-8jin6oru	62	15	be	be	VB
cord-263157-8jin6oru	62	16	virtually	virtually	RB
cord-263157-8jin6oru	62	17	impossible	impossible	JJ
cord-263157-8jin6oru	62	18	to	to	TO
cord-263157-8jin6oru	62	19	prevent	prevent	VB
cord-263157-8jin6oru	62	20	the	the	DT
cord-263157-8jin6oru	62	21	formation	formation	NN
cord-263157-8jin6oru	62	22	of	of	IN
cord-263157-8jin6oru	62	23	integrated	integrate	VBN
cord-263157-8jin6oru	62	24	provirus	provirus	NNP
cord-263157-8jin6oru	62	25	and	and	CC
cord-263157-8jin6oru	62	26	,	,	,
cord-263157-8jin6oru	62	27	as	as	IN
cord-263157-8jin6oru	62	28	a	a	DT
cord-263157-8jin6oru	62	29	result	result	NN
cord-263157-8jin6oru	62	30	,	,	,
cord-263157-8jin6oru	62	31	to	to	TO
cord-263157-8jin6oru	62	32	sterilize	sterilize	VB
cord-263157-8jin6oru	62	33	cells	cell	NNS
cord-263157-8jin6oru	62	34	from	from	IN
cord-263157-8jin6oru	62	35	infection	infection	NN
cord-263157-8jin6oru	62	36	.	.	.
cord-263157-8jin6oru	63	1	Targeting	target	VBG
cord-263157-8jin6oru	63	2	the	the	DT
cord-263157-8jin6oru	63	3	incoming	incoming	JJ
cord-263157-8jin6oru	63	4	viral	viral	JJ
cord-263157-8jin6oru	63	5	RNA	RNA	NNP
cord-263157-8jin6oru	63	6	may	may	MD
cord-263157-8jin6oru	63	7	have	have	VB
cord-263157-8jin6oru	63	8	several	several	JJ
cord-263157-8jin6oru	63	9	advantages	advantage	NNS
cord-263157-8jin6oru	63	10	,	,	,
cord-263157-8jin6oru	63	11	as	as	IN
cord-263157-8jin6oru	63	12	the	the	DT
cord-263157-8jin6oru	63	13	RNAi	RNAi	NNP
cord-263157-8jin6oru	63	14	machinery	machinery	NN
cord-263157-8jin6oru	63	15	would	would	MD
cord-263157-8jin6oru	63	16	only	only	RB
cord-263157-8jin6oru	63	17	have	have	VB
cord-263157-8jin6oru	63	18	to	to	TO
cord-263157-8jin6oru	63	19	deal	deal	VB
cord-263157-8jin6oru	63	20	with	with	IN
cord-263157-8jin6oru	63	21	two	two	CD
cord-263157-8jin6oru	63	22	or	or	CC
cord-263157-8jin6oru	63	23	a	a	DT
cord-263157-8jin6oru	63	24	few	few	JJ
cord-263157-8jin6oru	63	25	(	(	-LRB-
cord-263157-8jin6oru	63	26	in	in	IN
cord-263157-8jin6oru	63	27	the	the	DT
cord-263157-8jin6oru	63	28	case	case	NN
cord-263157-8jin6oru	63	29	of	of	IN
cord-263157-8jin6oru	63	30	superinfection	superinfection	NN
cord-263157-8jin6oru	63	31	)	)	-RRB-
cord-263157-8jin6oru	63	32	genomic	genomic	JJ
cord-263157-8jin6oru	63	33	viral	viral	JJ
cord-263157-8jin6oru	63	34	RNAs	rna	NNS
cord-263157-8jin6oru	63	35	.	.	.
cord-263157-8jin6oru	64	1	However	however	RB
cord-263157-8jin6oru	64	2	,	,	,
cord-263157-8jin6oru	64	3	after	after	IN
cord-263157-8jin6oru	64	4	a	a	DT
cord-263157-8jin6oru	64	5	provirus	provirus	NN
cord-263157-8jin6oru	64	6	is	be	VBZ
cord-263157-8jin6oru	64	7	established	establish	VBN
cord-263157-8jin6oru	64	8	,	,	,
cord-263157-8jin6oru	64	9	several	several	JJ
cord-263157-8jin6oru	64	10	thousands	thousand	NNS
cord-263157-8jin6oru	64	11	of	of	IN
cord-263157-8jin6oru	64	12	viral	viral	JJ
cord-263157-8jin6oru	64	13	transcripts	transcript	NNS
cord-263157-8jin6oru	64	14	are	be	VBP
cord-263157-8jin6oru	64	15	generated	generate	VBN
cord-263157-8jin6oru	64	16	de	de	IN
cord-263157-8jin6oru	64	17	novo	novo	NNP
cord-263157-8jin6oru	64	18	in	in	IN
cord-263157-8jin6oru	64	19	the	the	DT
cord-263157-8jin6oru	64	20	infected	infected	JJ
cord-263157-8jin6oru	64	21	cell	cell	NN
cord-263157-8jin6oru	64	22	and	and	CC
cord-263157-8jin6oru	64	23	the	the	DT
cord-263157-8jin6oru	64	24	targeted	target	VBN
cord-263157-8jin6oru	64	25	degradation	degradation	NN
cord-263157-8jin6oru	64	26	of	of	IN
cord-263157-8jin6oru	64	27	these	these	DT
cord-263157-8jin6oru	64	28	may	may	MD
cord-263157-8jin6oru	64	29	be	be	VB
cord-263157-8jin6oru	64	30	more	more	RBR
cord-263157-8jin6oru	64	31	difficult	difficult	JJ
cord-263157-8jin6oru	64	32	for	for	IN
cord-263157-8jin6oru	64	33	the	the	DT
cord-263157-8jin6oru	64	34	RNAi	RNAi	NNP
cord-263157-8jin6oru	64	35	machinery	machinery	NN
cord-263157-8jin6oru	64	36	.	.	.
cord-263157-8jin6oru	65	1	Data	datum	NNS
cord-263157-8jin6oru	65	2	has	have	VBZ
cord-263157-8jin6oru	65	3	been	be	VBN
cord-263157-8jin6oru	65	4	conflicting	conflict	VBG
cord-263157-8jin6oru	65	5	as	as	IN
cord-263157-8jin6oru	65	6	to	to	IN
cord-263157-8jin6oru	65	7	whether	whether	IN
cord-263157-8jin6oru	65	8	RNAi	RNAi	NNS
cord-263157-8jin6oru	65	9	can	can	MD
cord-263157-8jin6oru	65	10	target	target	VB
cord-263157-8jin6oru	65	11	the	the	DT
cord-263157-8jin6oru	65	12	incoming	incoming	JJ
cord-263157-8jin6oru	65	13	genomic	genomic	JJ
cord-263157-8jin6oru	65	14	viral	viral	JJ
cord-263157-8jin6oru	65	15	RNA	rna	NN
cord-263157-8jin6oru	65	16	of	of	IN
cord-263157-8jin6oru	65	17	infecting	infect	VBG
cord-263157-8jin6oru	65	18	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	65	19	particles	particle	NNS
cord-263157-8jin6oru	65	20	.	.	.
cord-263157-8jin6oru	66	1	Several	several	JJ
cord-263157-8jin6oru	66	2	studies	study	NNS
cord-263157-8jin6oru	66	3	have	have	VBP
cord-263157-8jin6oru	66	4	reported	report	VBN
cord-263157-8jin6oru	66	5	degradation	degradation	NN
cord-263157-8jin6oru	66	6	of	of	IN
cord-263157-8jin6oru	66	7	the	the	DT
cord-263157-8jin6oru	66	8	incoming	incoming	JJ
cord-263157-8jin6oru	66	9	RNA	RNA	NNP
cord-263157-8jin6oru	66	10	genome	genome	NN
cord-263157-8jin6oru	66	11	in	in	IN
cord-263157-8jin6oru	66	12	cells	cell	NNS
cord-263157-8jin6oru	66	13	transfected	transfecte	VBN
cord-263157-8jin6oru	66	14	with	with	IN
cord-263157-8jin6oru	66	15	artificial	artificial	JJ
cord-263157-8jin6oru	66	16	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	66	17	or	or	CC
cord-263157-8jin6oru	66	18	stably	stably	RB
cord-263157-8jin6oru	66	19	expressing	express	VBG
cord-263157-8jin6oru	66	20	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	66	21	(	(	-LRB-
cord-263157-8jin6oru	66	22	18	18	CD
cord-263157-8jin6oru	66	23	-20	-20	CD
cord-263157-8jin6oru	66	24	,	,	,
cord-263157-8jin6oru	66	25	27	27	CD
cord-263157-8jin6oru	66	26	)	)	-RRB-
cord-263157-8jin6oru	66	27	.	.	.
cord-263157-8jin6oru	67	1	However	however	RB
cord-263157-8jin6oru	67	2	,	,	,
cord-263157-8jin6oru	67	3	other	other	JJ
cord-263157-8jin6oru	67	4	studies	study	NNS
cord-263157-8jin6oru	67	5	have	have	VBP
cord-263157-8jin6oru	67	6	reported	report	VBN
cord-263157-8jin6oru	67	7	an	an	DT
cord-263157-8jin6oru	67	8	absence	absence	NN
cord-263157-8jin6oru	67	9	of	of	IN
cord-263157-8jin6oru	67	10	RNAi	RNAi	NNS
cord-263157-8jin6oru	67	11	-	-	HYPH
cord-263157-8jin6oru	67	12	mediated	mediate	VBN
cord-263157-8jin6oru	67	13	degradation	degradation	NN
cord-263157-8jin6oru	67	14	of	of	IN
cord-263157-8jin6oru	67	15	the	the	DT
cord-263157-8jin6oru	67	16	genomic	genomic	JJ
cord-263157-8jin6oru	67	17	viral	viral	JJ
cord-263157-8jin6oru	67	18	RNA	RNA	NNP
cord-263157-8jin6oru	67	19	in	in	IN
cord-263157-8jin6oru	67	20	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	67	21	-	-	HYPH
cord-263157-8jin6oru	67	22	transfected	transfecte	VBN
cord-263157-8jin6oru	67	23	or	or	CC
cord-263157-8jin6oru	67	24	siRNA	sirna	NN
cord-263157-8jin6oru	67	25	-	-	HYPH
cord-263157-8jin6oru	67	26	producing	produce	VBG
cord-263157-8jin6oru	67	27	cells	cell	NNS
cord-263157-8jin6oru	67	28	(	(	-LRB-
cord-263157-8jin6oru	67	29	22	22	CD
cord-263157-8jin6oru	67	30	,	,	,
cord-263157-8jin6oru	67	31	28	28	CD
cord-263157-8jin6oru	67	32	,	,	,
cord-263157-8jin6oru	67	33	29	29	CD
cord-263157-8jin6oru	67	34	)	)	-RRB-
cord-263157-8jin6oru	67	35	.	.	.
cord-263157-8jin6oru	68	1	Moreover	moreover	RB
cord-263157-8jin6oru	68	2	,	,	,
cord-263157-8jin6oru	68	3	a	a	DT
cord-263157-8jin6oru	68	4	study	study	NN
cord-263157-8jin6oru	68	5	with	with	IN
cord-263157-8jin6oru	68	6	the	the	DT
cord-263157-8jin6oru	68	7	non	non	JJ
cord-263157-8jin6oru	68	8	-	-	JJ
cord-263157-8jin6oru	68	9	segmented	segmented	JJ
cord-263157-8jin6oru	68	10	,	,	,
cord-263157-8jin6oru	68	11	negative	negative	JJ
cord-263157-8jin6oru	68	12	-	-	HYPH
cord-263157-8jin6oru	68	13	strand	strand	NN
cord-263157-8jin6oru	68	14	RNA	RNA	NNP
cord-263157-8jin6oru	68	15	virus	virus	NN
cord-263157-8jin6oru	68	16	respiratory	respiratory	JJ
cord-263157-8jin6oru	68	17	syncytial	syncytial	NN
cord-263157-8jin6oru	68	18	(	(	-LRB-
cord-263157-8jin6oru	68	19	RSV	RSV	NNP
cord-263157-8jin6oru	68	20	)	)	-RRB-
cord-263157-8jin6oru	68	21	showed	show	VBD
cord-263157-8jin6oru	68	22	that	that	IN
cord-263157-8jin6oru	68	23	genomic	genomic	JJ
cord-263157-8jin6oru	68	24	and	and	CC
cord-263157-8jin6oru	68	25	antigenomic	antigenomic	JJ
cord-263157-8jin6oru	68	26	viral	viral	JJ
cord-263157-8jin6oru	68	27	RNAs	rna	NNS
cord-263157-8jin6oru	68	28	encapsidated	encapsidate	VBN
cord-263157-8jin6oru	68	29	in	in	IN
cord-263157-8jin6oru	68	30	the	the	DT
cord-263157-8jin6oru	68	31	virus	virus	NN
cord-263157-8jin6oru	68	32	nucleocapsid	nucleocapsid	NN
cord-263157-8jin6oru	68	33	protein	protein	NN
cord-263157-8jin6oru	68	34	were	be	VBD
cord-263157-8jin6oru	68	35	not	not	RB
cord-263157-8jin6oru	68	36	susceptible	susceptible	JJ
cord-263157-8jin6oru	68	37	to	to	IN
cord-263157-8jin6oru	68	38	siRNA	sirna	NN
cord-263157-8jin6oru	68	39	-	-	HYPH
cord-263157-8jin6oru	68	40	mediated	mediate	VBN
cord-263157-8jin6oru	68	41	silencing	silencing	NN
cord-263157-8jin6oru	68	42	,	,	,
cord-263157-8jin6oru	68	43	but	but	CC
cord-263157-8jin6oru	68	44	viral	viral	JJ
cord-263157-8jin6oru	68	45	mRNAs	mrnas	CD
cord-263157-8jin6oru	68	46	were	be	VBD
cord-263157-8jin6oru	68	47	highly	highly	RB
cord-263157-8jin6oru	68	48	susceptible	susceptible	JJ
cord-263157-8jin6oru	68	49	(	(	-LRB-
cord-263157-8jin6oru	68	50	30	30	CD
cord-263157-8jin6oru	68	51	)	)	-RRB-
cord-263157-8jin6oru	68	52	.	.	.
cord-263157-8jin6oru	69	1	The	the	DT
cord-263157-8jin6oru	69	2	mechanisms	mechanism	NNS
cord-263157-8jin6oru	69	3	underscoring	underscore	VBG
cord-263157-8jin6oru	69	4	the	the	DT
cord-263157-8jin6oru	69	5	efficiency	efficiency	NN
cord-263157-8jin6oru	69	6	of	of	IN
cord-263157-8jin6oru	69	7	specific	specific	JJ
cord-263157-8jin6oru	69	8	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	69	9	in	in	IN
cord-263157-8jin6oru	69	10	targeting	target	VBG
cord-263157-8jin6oru	69	11	genes	gene	NNS
cord-263157-8jin6oru	69	12	is	be	VBZ
cord-263157-8jin6oru	69	13	not	not	RB
cord-263157-8jin6oru	69	14	completely	completely	RB
cord-263157-8jin6oru	69	15	known	know	VBN
cord-263157-8jin6oru	69	16	.	.	.
cord-263157-8jin6oru	70	1	RNAi	RNAi	NNP
cord-263157-8jin6oru	70	2	efficiency	efficiency	NN
cord-263157-8jin6oru	70	3	is	be	VBZ
cord-263157-8jin6oru	70	4	known	know	VBN
cord-263157-8jin6oru	70	5	to	to	TO
cord-263157-8jin6oru	70	6	be	be	VB
cord-263157-8jin6oru	70	7	influenced	influence	VBN
cord-263157-8jin6oru	70	8	by	by	IN
cord-263157-8jin6oru	70	9	local	local	JJ
cord-263157-8jin6oru	70	10	RNA	RNA	NNP
cord-263157-8jin6oru	70	11	structure	structure	NN
cord-263157-8jin6oru	70	12	of	of	IN
cord-263157-8jin6oru	70	13	the	the	DT
cord-263157-8jin6oru	70	14	target	target	NN
cord-263157-8jin6oru	70	15	sequence	sequence	NN
cord-263157-8jin6oru	70	16	(	(	-LRB-
cord-263157-8jin6oru	70	17	31	31	CD
cord-263157-8jin6oru	70	18	)	)	-RRB-
cord-263157-8jin6oru	70	19	.	.	.
cord-263157-8jin6oru	71	1	Randomly	randomly	RB
cord-263157-8jin6oru	71	2	selected	select	VBD
cord-263157-8jin6oru	71	3	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	71	4	against	against	IN
cord-263157-8jin6oru	71	5	a	a	DT
cord-263157-8jin6oru	71	6	target	target	NN
cord-263157-8jin6oru	71	7	sequence	sequence	NN
cord-263157-8jin6oru	72	1	showed	show	VBD
cord-263157-8jin6oru	72	2	a	a	DT
cord-263157-8jin6oru	72	3	large	large	JJ
cord-263157-8jin6oru	72	4	variation	variation	NN
cord-263157-8jin6oru	72	5	in	in	IN
cord-263157-8jin6oru	72	6	their	-PRON-	PRP$
cord-263157-8jin6oru	72	7	efficiency	efficiency	NN
cord-263157-8jin6oru	72	8	(	(	-LRB-
cord-263157-8jin6oru	72	9	32	32	CD
cord-263157-8jin6oru	72	10	)	)	-RRB-
cord-263157-8jin6oru	72	11	.	.	.
cord-263157-8jin6oru	73	1	It	-PRON-	PRP
cord-263157-8jin6oru	73	2	has	have	VBZ
cord-263157-8jin6oru	73	3	been	be	VBN
cord-263157-8jin6oru	73	4	argued	argue	VBN
cord-263157-8jin6oru	73	5	that	that	IN
cord-263157-8jin6oru	73	6	some	some	DT
cord-263157-8jin6oru	73	7	regions	region	NNS
cord-263157-8jin6oru	73	8	of	of	IN
cord-263157-8jin6oru	73	9	genomic	genomic	JJ
cord-263157-8jin6oru	73	10	viral	viral	JJ
cord-263157-8jin6oru	73	11	RNA	RNA	NNP
cord-263157-8jin6oru	73	12	might	may	MD
cord-263157-8jin6oru	73	13	be	be	VB
cord-263157-8jin6oru	73	14	less	less	RBR
cord-263157-8jin6oru	73	15	accessible	accessible	JJ
cord-263157-8jin6oru	73	16	to	to	IN
cord-263157-8jin6oru	73	17	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	73	18	when	when	WRB
cord-263157-8jin6oru	73	19	the	the	DT
cord-263157-8jin6oru	73	20	RNA	RNA	NNP
cord-263157-8jin6oru	73	21	is	be	VBZ
cord-263157-8jin6oru	73	22	contained	contain	VBN
cord-263157-8jin6oru	73	23	in	in	IN
cord-263157-8jin6oru	73	24	the	the	DT
cord-263157-8jin6oru	73	25	virus	virus	NN
cord-263157-8jin6oru	73	26	reverse	reverse	NN
cord-263157-8jin6oru	73	27	transcription	transcription	NN
cord-263157-8jin6oru	73	28	complex	complex	NN
cord-263157-8jin6oru	73	29	;	;	:
cord-263157-8jin6oru	73	30	therefore	therefore	RB
cord-263157-8jin6oru	73	31	,	,	,
cord-263157-8jin6oru	73	32	some	some	DT
cord-263157-8jin6oru	73	33	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	73	34	might	may	MD
cord-263157-8jin6oru	73	35	be	be	VB
cord-263157-8jin6oru	73	36	more	more	RBR
cord-263157-8jin6oru	73	37	effective	effective	JJ
cord-263157-8jin6oru	73	38	than	than	IN
cord-263157-8jin6oru	73	39	others	other	NNS
cord-263157-8jin6oru	73	40	in	in	IN
cord-263157-8jin6oru	73	41	inhibiting	inhibit	VBG
cord-263157-8jin6oru	73	42	this	this	DT
cord-263157-8jin6oru	73	43	early	early	JJ
cord-263157-8jin6oru	73	44	step	step	NN
cord-263157-8jin6oru	73	45	in	in	IN
cord-263157-8jin6oru	73	46	virus	virus	NN
cord-263157-8jin6oru	73	47	replication	replication	NN
cord-263157-8jin6oru	73	48	(	(	-LRB-
cord-263157-8jin6oru	73	49	26	26	CD
cord-263157-8jin6oru	73	50	)	)	-RRB-
cord-263157-8jin6oru	73	51	.	.	.
cord-263157-8jin6oru	74	1	Recently	recently	RB
cord-263157-8jin6oru	74	2	,	,	,
cord-263157-8jin6oru	74	3	a	a	DT
cord-263157-8jin6oru	74	4	more	more	RBR
cord-263157-8jin6oru	74	5	exhaustive	exhaustive	JJ
cord-263157-8jin6oru	74	6	study	study	NN
cord-263157-8jin6oru	74	7	was	be	VBD
cord-263157-8jin6oru	74	8	performed	perform	VBN
cord-263157-8jin6oru	74	9	to	to	TO
cord-263157-8jin6oru	74	10	address	address	VB
cord-263157-8jin6oru	74	11	this	this	DT
cord-263157-8jin6oru	74	12	issue	issue	NN
cord-263157-8jin6oru	74	13	(	(	-LRB-
cord-263157-8jin6oru	74	14	33	33	CD
cord-263157-8jin6oru	74	15	)	)	-RRB-
cord-263157-8jin6oru	74	16	.	.	.
cord-263157-8jin6oru	75	1	In	in	IN
cord-263157-8jin6oru	75	2	this	this	DT
cord-263157-8jin6oru	75	3	study	study	NN
cord-263157-8jin6oru	75	4	,	,	,
cord-263157-8jin6oru	75	5	the	the	DT
cord-263157-8jin6oru	75	6	transduction	transduction	NN
cord-263157-8jin6oru	75	7	efficiency	efficiency	NN
cord-263157-8jin6oru	75	8	of	of	IN
cord-263157-8jin6oru	75	9	a	a	DT
cord-263157-8jin6oru	75	10	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	75	11	vector	vector	NN
cord-263157-8jin6oru	75	12	,	,	,
cord-263157-8jin6oru	75	13	as	as	IN
cord-263157-8jin6oru	75	14	measured	measure	VBN
cord-263157-8jin6oru	75	15	by	by	IN
cord-263157-8jin6oru	75	16	the	the	DT
cord-263157-8jin6oru	75	17	number	number	NN
cord-263157-8jin6oru	75	18	of	of	IN
cord-263157-8jin6oru	75	19	successful	successful	JJ
cord-263157-8jin6oru	75	20	integration	integration	NN
cord-263157-8jin6oru	75	21	events	event	NNS
cord-263157-8jin6oru	75	22	,	,	,
cord-263157-8jin6oru	75	23	was	be	VBD
cord-263157-8jin6oru	75	24	determined	determine	VBN
cord-263157-8jin6oru	75	25	in	in	IN
cord-263157-8jin6oru	75	26	a	a	DT
cord-263157-8jin6oru	75	27	cell	cell	NN
cord-263157-8jin6oru	75	28	line	line	NN
cord-263157-8jin6oru	75	29	stably	stably	RB
cord-263157-8jin6oru	75	30	expressing	express	VBG
cord-263157-8jin6oru	75	31	an	an	DT
cord-263157-8jin6oru	75	32	siRNA	sirna	NN
cord-263157-8jin6oru	75	33	targeting	target	VBG
cord-263157-8jin6oru	75	34	the	the	DT
cord-263157-8jin6oru	75	35	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	75	36	Nef	Nef	NNP
cord-263157-8jin6oru	75	37	sequence	sequence	NN
cord-263157-8jin6oru	75	38	.	.	.
cord-263157-8jin6oru	76	1	The	the	DT
cord-263157-8jin6oru	76	2	results	result	NNS
cord-263157-8jin6oru	76	3	indicated	indicate	VBD
cord-263157-8jin6oru	76	4	a	a	DT
cord-263157-8jin6oru	76	5	similar	similar	JJ
cord-263157-8jin6oru	76	6	transduction	transduction	NN
cord-263157-8jin6oru	76	7	efficiency	efficiency	NN
cord-263157-8jin6oru	76	8	for	for	IN
cord-263157-8jin6oru	76	9	vectors	vector	NNS
cord-263157-8jin6oru	76	10	regardless	regardless	RB
cord-263157-8jin6oru	76	11	of	of	IN
cord-263157-8jin6oru	76	12	the	the	DT
cord-263157-8jin6oru	76	13	presence	presence	NN
cord-263157-8jin6oru	76	14	or	or	CC
cord-263157-8jin6oru	76	15	absence	absence	NN
cord-263157-8jin6oru	76	16	of	of	IN
cord-263157-8jin6oru	76	17	the	the	DT
cord-263157-8jin6oru	76	18	Nef	Nef	NNP
cord-263157-8jin6oru	76	19	target	target	NN
cord-263157-8jin6oru	76	20	sequence	sequence	NN
cord-263157-8jin6oru	76	21	in	in	IN
cord-263157-8jin6oru	76	22	their	-PRON-	PRP$
cord-263157-8jin6oru	76	23	genome	genome	NN
cord-263157-8jin6oru	76	24	.	.	.
cord-263157-8jin6oru	77	1	Moreover	moreover	RB
cord-263157-8jin6oru	77	2	,	,	,
cord-263157-8jin6oru	77	3	no	no	DT
cord-263157-8jin6oru	77	4	reduced	reduce	VBN
cord-263157-8jin6oru	77	5	transduction	transduction	NN
cord-263157-8jin6oru	77	6	efficiencies	efficiency	NNS
cord-263157-8jin6oru	77	7	were	be	VBD
cord-263157-8jin6oru	77	8	observed	observe	VBN
cord-263157-8jin6oru	77	9	in	in	IN
cord-263157-8jin6oru	77	10	the	the	DT
cord-263157-8jin6oru	77	11	presence	presence	NN
cord-263157-8jin6oru	77	12	of	of	IN
cord-263157-8jin6oru	77	13	multiple	multiple	JJ
cord-263157-8jin6oru	77	14	other	other	JJ
cord-263157-8jin6oru	77	15	stably	stably	RB
cord-263157-8jin6oru	77	16	expressed	express	VBD
cord-263157-8jin6oru	77	17	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	77	18	targeting	target	VBG
cord-263157-8jin6oru	77	19	the	the	DT
cord-263157-8jin6oru	77	20	vector	vector	NN
cord-263157-8jin6oru	77	21	genome	genome	NN
cord-263157-8jin6oru	77	22	,	,	,
cord-263157-8jin6oru	77	23	or	or	CC
cord-263157-8jin6oru	77	24	when	when	WRB
cord-263157-8jin6oru	77	25	synthetic	synthetic	JJ
cord-263157-8jin6oru	77	26	siRNA	siRNA	NNP
cord-263157-8jin6oru	77	27	targeting	target	VBG
cord-263157-8jin6oru	77	28	Nef	Nef	NNP
cord-263157-8jin6oru	77	29	was	be	VBD
cord-263157-8jin6oru	77	30	transiently	transiently	RB
cord-263157-8jin6oru	77	31	transfected	transfecte	VBN
cord-263157-8jin6oru	77	32	prior	prior	RB
cord-263157-8jin6oru	77	33	to	to	IN
cord-263157-8jin6oru	77	34	transduction	transduction	NN
cord-263157-8jin6oru	77	35	.	.	.
cord-263157-8jin6oru	78	1	These	these	DT
cord-263157-8jin6oru	78	2	results	result	NNS
cord-263157-8jin6oru	78	3	highlight	highlight	VBP
cord-263157-8jin6oru	78	4	the	the	DT
cord-263157-8jin6oru	78	5	difficulties	difficulty	NNS
cord-263157-8jin6oru	78	6	of	of	IN
cord-263157-8jin6oru	78	7	designing	design	VBG
cord-263157-8jin6oru	78	8	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	78	9	RNAi	RNAi	NNS
cord-263157-8jin6oru	78	10	strategies	strategy	NNS
cord-263157-8jin6oru	78	11	aimed	aim	VBN
cord-263157-8jin6oru	78	12	at	at	IN
cord-263157-8jin6oru	78	13	preventing	prevent	VBG
cord-263157-8jin6oru	78	14	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	78	15	proviral	proviral	JJ
cord-263157-8jin6oru	78	16	integration	integration	NN
cord-263157-8jin6oru	78	17	.	.	.
cord-263157-8jin6oru	79	1	Silencing	silence	VBG
cord-263157-8jin6oru	79	2	Tat	Tat	NNP
cord-263157-8jin6oru	79	3	,	,	,
cord-263157-8jin6oru	79	4	a	a	DT
cord-263157-8jin6oru	79	5	factor	factor	NN
cord-263157-8jin6oru	79	6	that	that	WDT
cord-263157-8jin6oru	79	7	must	must	MD
cord-263157-8jin6oru	79	8	be	be	VB
cord-263157-8jin6oru	79	9	expressed	express	VBN
cord-263157-8jin6oru	79	10	before	before	IN
cord-263157-8jin6oru	79	11	efficient	efficient	JJ
cord-263157-8jin6oru	79	12	provirus	provirus	NN
cord-263157-8jin6oru	79	13	transcription	transcription	NN
cord-263157-8jin6oru	79	14	can	can	MD
cord-263157-8jin6oru	79	15	occur	occur	VB
cord-263157-8jin6oru	79	16	,	,	,
cord-263157-8jin6oru	79	17	may	may	MD
cord-263157-8jin6oru	79	18	make	make	VB
cord-263157-8jin6oru	79	19	it	-PRON-	PRP
cord-263157-8jin6oru	79	20	easier	easy	JJR
cord-263157-8jin6oru	79	21	to	to	TO
cord-263157-8jin6oru	79	22	target	target	VB
cord-263157-8jin6oru	79	23	other	other	JJ
cord-263157-8jin6oru	79	24	viral	viral	JJ
cord-263157-8jin6oru	79	25	transcripts	transcript	NNS
cord-263157-8jin6oru	79	26	by	by	IN
cord-263157-8jin6oru	79	27	virtue	virtue	NN
cord-263157-8jin6oru	79	28	of	of	IN
cord-263157-8jin6oru	79	29	their	-PRON-	PRP$
cord-263157-8jin6oru	79	30	lower	low	JJR
cord-263157-8jin6oru	79	31	abundance	abundance	NN
cord-263157-8jin6oru	79	32	when	when	WRB
cord-263157-8jin6oru	79	33	Tat	tat	NN
cord-263157-8jin6oru	79	34	function	function	NN
cord-263157-8jin6oru	79	35	is	be	VBZ
cord-263157-8jin6oru	79	36	compromised	compromise	VBN
cord-263157-8jin6oru	79	37	(	(	-LRB-
cord-263157-8jin6oru	79	38	26	26	CD
cord-263157-8jin6oru	79	39	)	)	-RRB-
cord-263157-8jin6oru	79	40	.	.	.
cord-263157-8jin6oru	80	1	Synthetic	Synthetic	NNP
cord-263157-8jin6oru	80	2	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	80	3	mediate	mediate	VBP
cord-263157-8jin6oru	80	4	strong	strong	JJ
cord-263157-8jin6oru	80	5	and	and	CC
cord-263157-8jin6oru	80	6	specific	specific	JJ
cord-263157-8jin6oru	80	7	but	but	CC
cord-263157-8jin6oru	80	8	transient	transient	JJ
cord-263157-8jin6oru	80	9	suppression	suppression	NN
cord-263157-8jin6oru	80	10	of	of	IN
cord-263157-8jin6oru	80	11	gene	gene	NN
cord-263157-8jin6oru	80	12	expression	expression	NN
cord-263157-8jin6oru	80	13	(	(	-LRB-
cord-263157-8jin6oru	80	14	18	18	CD
cord-263157-8jin6oru	80	15	-20	-20	CD
cord-263157-8jin6oru	80	16	,	,	,
cord-263157-8jin6oru	80	17	28	28	CD
cord-263157-8jin6oru	80	18	)	)	-RRB-
cord-263157-8jin6oru	80	19	.	.	.
cord-263157-8jin6oru	81	1	The	the	DT
cord-263157-8jin6oru	81	2	transient	transient	JJ
cord-263157-8jin6oru	81	3	reduction	reduction	NN
cord-263157-8jin6oru	81	4	in	in	IN
cord-263157-8jin6oru	81	5	gene	gene	NN
cord-263157-8jin6oru	81	6	expression	expression	NN
cord-263157-8jin6oru	81	7	by	by	IN
cord-263157-8jin6oru	81	8	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	81	9	severely	severely	RB
cord-263157-8jin6oru	81	10	restricts	restrict	VBZ
cord-263157-8jin6oru	81	11	its	-PRON-	PRP$
cord-263157-8jin6oru	81	12	applications	application	NNS
cord-263157-8jin6oru	81	13	in	in	IN
cord-263157-8jin6oru	81	14	a	a	DT
cord-263157-8jin6oru	81	15	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	81	16	setting	setting	NN
cord-263157-8jin6oru	81	17	of	of	IN
cord-263157-8jin6oru	81	18	a	a	DT
cord-263157-8jin6oru	81	19	persistent	persistent	JJ
cord-263157-8jin6oru	81	20	infection	infection	NN
cord-263157-8jin6oru	81	21	,	,	,
cord-263157-8jin6oru	81	22	such	such	JJ
cord-263157-8jin6oru	81	23	as	as	IN
cord-263157-8jin6oru	81	24	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	81	25	infection	infection	NN
cord-263157-8jin6oru	81	26	.	.	.
cord-263157-8jin6oru	82	1	However	however	RB
cord-263157-8jin6oru	82	2	,	,	,
cord-263157-8jin6oru	82	3	this	this	DT
cord-263157-8jin6oru	82	4	limitation	limitation	NN
cord-263157-8jin6oru	82	5	was	be	VBD
cord-263157-8jin6oru	82	6	quickly	quickly	RB
cord-263157-8jin6oru	82	7	overcome	overcome	VBN
cord-263157-8jin6oru	82	8	with	with	IN
cord-263157-8jin6oru	82	9	the	the	DT
cord-263157-8jin6oru	82	10	use	use	NN
cord-263157-8jin6oru	82	11	of	of	IN
cord-263157-8jin6oru	82	12	plasmids	plasmid	NNS
cord-263157-8jin6oru	82	13	or	or	CC
cord-263157-8jin6oru	82	14	viral	viral	JJ
cord-263157-8jin6oru	82	15	vectors	vector	NNS
cord-263157-8jin6oru	82	16	that	that	WDT
cord-263157-8jin6oru	82	17	expressed	express	VBD
cord-263157-8jin6oru	82	18	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	82	19	from	from	IN
cord-263157-8jin6oru	82	20	polymerase	polymerase	NN
cord-263157-8jin6oru	82	21	-	-	HYPH
cord-263157-8jin6oru	82	22	III	iii	CD
cord-263157-8jin6oru	82	23	transcription	transcription	NN
cord-263157-8jin6oru	82	24	units	unit	NNS
cord-263157-8jin6oru	82	25	.	.	.
cord-263157-8jin6oru	83	1	The	the	DT
cord-263157-8jin6oru	83	2	sense	sense	NN
cord-263157-8jin6oru	83	3	and	and	CC
cord-263157-8jin6oru	83	4	antisense	antisense	NN
cord-263157-8jin6oru	83	5	strands	strand	NNS
cord-263157-8jin6oru	83	6	of	of	IN
cord-263157-8jin6oru	83	7	an	an	DT
cord-263157-8jin6oru	83	8	siRNA	siRNA	NNP
cord-263157-8jin6oru	83	9	were	be	VBD
cord-263157-8jin6oru	83	10	expressed	express	VBN
cord-263157-8jin6oru	83	11	from	from	IN
cord-263157-8jin6oru	83	12	two	two	CD
cord-263157-8jin6oru	83	13	different	different	JJ
cord-263157-8jin6oru	83	14	promoters	promoter	NNS
cord-263157-8jin6oru	83	15	and	and	CC
cord-263157-8jin6oru	83	16	RNAi	RNAi	NNS
cord-263157-8jin6oru	83	17	was	be	VBD
cord-263157-8jin6oru	83	18	triggered	trigger	VBN
cord-263157-8jin6oru	83	19	upon	upon	IN
cord-263157-8jin6oru	83	20	annealing	anneal	VBG
cord-263157-8jin6oru	83	21	of	of	IN
cord-263157-8jin6oru	83	22	the	the	DT
cord-263157-8jin6oru	83	23	two	two	CD
cord-263157-8jin6oru	83	24	strands	strand	NNS
cord-263157-8jin6oru	83	25	(	(	-LRB-
cord-263157-8jin6oru	83	26	16	16	CD
cord-263157-8jin6oru	83	27	)	)	-RRB-
cord-263157-8jin6oru	83	28	.	.	.
cord-263157-8jin6oru	84	1	A	a	DT
cord-263157-8jin6oru	84	2	more	more	RBR
cord-263157-8jin6oru	84	3	potent	potent	JJ
cord-263157-8jin6oru	84	4	gene	gene	NN
cord-263157-8jin6oru	84	5	silencing	silencing	NN
cord-263157-8jin6oru	84	6	was	be	VBD
cord-263157-8jin6oru	84	7	achieved	achieve	VBN
cord-263157-8jin6oru	84	8	when	when	WRB
cord-263157-8jin6oru	84	9	the	the	DT
cord-263157-8jin6oru	84	10	sense	sense	NN
cord-263157-8jin6oru	84	11	and	and	CC
cord-263157-8jin6oru	84	12	antisense	antisense	NN
cord-263157-8jin6oru	84	13	strands	strand	NNS
cord-263157-8jin6oru	84	14	were	be	VBD
cord-263157-8jin6oru	84	15	expressed	express	VBN
cord-263157-8jin6oru	84	16	as	as	IN
cord-263157-8jin6oru	84	17	a	a	DT
cord-263157-8jin6oru	84	18	single	single	JJ
cord-263157-8jin6oru	84	19	transcript	transcript	NN
cord-263157-8jin6oru	84	20	with	with	IN
cord-263157-8jin6oru	84	21	the	the	DT
cord-263157-8jin6oru	84	22	ability	ability	NN
cord-263157-8jin6oru	84	23	to	to	TO
cord-263157-8jin6oru	84	24	form	form	VB
cord-263157-8jin6oru	84	25	a	a	DT
cord-263157-8jin6oru	84	26	duplex	duplex	JJ
cord-263157-8jin6oru	84	27	hairpin	hairpin	NN
cord-263157-8jin6oru	84	28	structure	structure	NN
cord-263157-8jin6oru	84	29	(	(	-LRB-
cord-263157-8jin6oru	84	30	34	34	CD
cord-263157-8jin6oru	84	31	)	)	-RRB-
cord-263157-8jin6oru	84	32	.	.	.
cord-263157-8jin6oru	85	1	Indeed	indeed	RB
cord-263157-8jin6oru	85	2	,	,	,
cord-263157-8jin6oru	85	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	85	4	replication	replication	NN
cord-263157-8jin6oru	85	5	could	could	MD
cord-263157-8jin6oru	85	6	be	be	VB
cord-263157-8jin6oru	85	7	efficiently	efficiently	RB
cord-263157-8jin6oru	85	8	inhibited	inhibit	VBN
cord-263157-8jin6oru	85	9	with	with	IN
cord-263157-8jin6oru	85	10	such	such	JJ
cord-263157-8jin6oru	85	11	short	short	JJ
cord-263157-8jin6oru	85	12	hairpin	hairpin	NN
cord-263157-8jin6oru	85	13	RNAs	rna	NNS
cord-263157-8jin6oru	85	14	(	(	-LRB-
cord-263157-8jin6oru	85	15	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	85	16	)	)	-RRB-
cord-263157-8jin6oru	85	17	in	in	IN
cord-263157-8jin6oru	85	18	stably	stably	RB
cord-263157-8jin6oru	85	19	transduced	transduce	VBN
cord-263157-8jin6oru	85	20	cell	cell	NN
cord-263157-8jin6oru	85	21	lines	line	NNS
cord-263157-8jin6oru	85	22	(	(	-LRB-
cord-263157-8jin6oru	85	23	34	34	CD
cord-263157-8jin6oru	85	24	-37	-37	CD
cord-263157-8jin6oru	85	25	)	)	-RRB-
cord-263157-8jin6oru	85	26	.	.	.
cord-263157-8jin6oru	86	1	An	an	DT
cord-263157-8jin6oru	86	2	additional	additional	JJ
cord-263157-8jin6oru	86	3	benefit	benefit	NN
cord-263157-8jin6oru	86	4	in	in	IN
cord-263157-8jin6oru	86	5	using	use	VBG
cord-263157-8jin6oru	86	6	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	86	7	is	be	VBZ
cord-263157-8jin6oru	86	8	that	that	IN
cord-263157-8jin6oru	86	9	these	these	DT
cord-263157-8jin6oru	86	10	can	can	MD
cord-263157-8jin6oru	86	11	be	be	VB
cord-263157-8jin6oru	86	12	processed	process	VBN
cord-263157-8jin6oru	86	13	by	by	IN
cord-263157-8jin6oru	86	14	Dicer	Dicer	NNP
cord-263157-8jin6oru	86	15	like	like	IN
cord-263157-8jin6oru	86	16	the	the	DT
cord-263157-8jin6oru	86	17	endogenous	endogenous	JJ
cord-263157-8jin6oru	86	18	microRNAs	microRNAs	NNPS
cord-263157-8jin6oru	86	19	(	(	-LRB-
cord-263157-8jin6oru	86	20	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	86	21	)	)	-RRB-
cord-263157-8jin6oru	86	22	.	.	.
cord-263157-8jin6oru	87	1	Tat	Tat	NNP
cord-263157-8jin6oru	87	2	siRNA	siRNA	NNP
cord-263157-8jin6oru	87	3	delivered	deliver	VBD
cord-263157-8jin6oru	87	4	as	as	IN
cord-263157-8jin6oru	87	5	a	a	DT
cord-263157-8jin6oru	87	6	pre	pre	JJ
cord-263157-8jin6oru	87	7	-	-	JJ
cord-263157-8jin6oru	87	8	miRNA	mirna	JJ
cord-263157-8jin6oru	87	9	precursor	precursor	NN
cord-263157-8jin6oru	87	10	was	be	VBD
cord-263157-8jin6oru	87	11	80	80	CD
cord-263157-8jin6oru	87	12	%	%	NN
cord-263157-8jin6oru	87	13	more	more	JJR
cord-263157-8jin6oru	87	14	effective	effective	JJ
cord-263157-8jin6oru	87	15	in	in	IN
cord-263157-8jin6oru	87	16	reducing	reduce	VBG
cord-263157-8jin6oru	87	17	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	87	18	p24	p24	NN
cord-263157-8jin6oru	87	19	antigen	antigen	NN
cord-263157-8jin6oru	87	20	production	production	NN
cord-263157-8jin6oru	87	21	than	than	IN
cord-263157-8jin6oru	87	22	Tat	Tat	NNP
cord-263157-8jin6oru	87	23	siRNA	siRNA	NNP
cord-263157-8jin6oru	87	24	expressed	express	VBD
cord-263157-8jin6oru	87	25	as	as	IN
cord-263157-8jin6oru	87	26	a	a	DT
cord-263157-8jin6oru	87	27	conventional	conventional	JJ
cord-263157-8jin6oru	87	28	shRNA	shrna	NN
cord-263157-8jin6oru	87	29	.	.	.
cord-263157-8jin6oru	88	1	Modeling	model	VBG
cord-263157-8jin6oru	88	2	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	88	3	after	after	IN
cord-263157-8jin6oru	88	4	endogenous	endogenous	JJ
cord-263157-8jin6oru	88	5	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	88	6	can	can	MD
cord-263157-8jin6oru	88	7	increase	increase	VB
cord-263157-8jin6oru	88	8	the	the	DT
cord-263157-8jin6oru	88	9	antiviral	antiviral	JJ
cord-263157-8jin6oru	88	10	potency	potency	NN
cord-263157-8jin6oru	88	11	of	of	IN
cord-263157-8jin6oru	88	12	RNAi	RNAi	NNP
cord-263157-8jin6oru	88	13	(	(	-LRB-
cord-263157-8jin6oru	88	14	38	38	CD
cord-263157-8jin6oru	88	15	)	)	-RRB-
cord-263157-8jin6oru	88	16	.	.	.
cord-263157-8jin6oru	89	1	As	as	IN
cord-263157-8jin6oru	89	2	discussed	discuss	VBN
cord-263157-8jin6oru	89	3	in	in	IN
cord-263157-8jin6oru	89	4	this	this	DT
cord-263157-8jin6oru	89	5	section	section	NN
cord-263157-8jin6oru	89	6	,	,	,
cord-263157-8jin6oru	89	7	an	an	DT
cord-263157-8jin6oru	89	8	exogenously	exogenously	RB
cord-263157-8jin6oru	89	9	induced	induce	VBN
cord-263157-8jin6oru	89	10	RNAi	RNAi	NNP
cord-263157-8jin6oru	89	11	response	response	NN
cord-263157-8jin6oru	89	12	in	in	IN
cord-263157-8jin6oru	89	13	mammalian	mammalian	JJ
cord-263157-8jin6oru	89	14	cells	cell	NNS
cord-263157-8jin6oru	89	15	mediated	mediate	VBN
cord-263157-8jin6oru	89	16	by	by	IN
cord-263157-8jin6oru	89	17	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	89	18	or	or	CC
cord-263157-8jin6oru	89	19	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	89	20	can	can	MD
cord-263157-8jin6oru	89	21	inhibit	inhibit	VB
cord-263157-8jin6oru	89	22	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	89	23	replication	replication	NN
cord-263157-8jin6oru	89	24	.	.	.
cord-263157-8jin6oru	90	1	These	these	DT
cord-263157-8jin6oru	90	2	results	result	NNS
cord-263157-8jin6oru	90	3	raise	raise	VBP
cord-263157-8jin6oru	90	4	the	the	DT
cord-263157-8jin6oru	90	5	question	question	NN
cord-263157-8jin6oru	90	6	of	of	IN
cord-263157-8jin6oru	90	7	whether	whether	IN
cord-263157-8jin6oru	90	8	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	90	9	interacts	interact	VBZ
cord-263157-8jin6oru	90	10	with	with	IN
cord-263157-8jin6oru	90	11	the	the	DT
cord-263157-8jin6oru	90	12	cellular	cellular	JJ
cord-263157-8jin6oru	90	13	RNAi	RNAi	NNP
cord-263157-8jin6oru	90	14	machinery	machinery	NN
cord-263157-8jin6oru	90	15	,	,	,
cord-263157-8jin6oru	90	16	and	and	CC
cord-263157-8jin6oru	90	17	understanding	understand	VBG
cord-263157-8jin6oru	90	18	the	the	DT
cord-263157-8jin6oru	90	19	potential	potential	JJ
cord-263157-8jin6oru	90	20	physiological	physiological	JJ
cord-263157-8jin6oru	90	21	interaction	interaction	NN
cord-263157-8jin6oru	90	22	between	between	IN
cord-263157-8jin6oru	90	23	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	90	24	and	and	CC
cord-263157-8jin6oru	90	25	the	the	DT
cord-263157-8jin6oru	90	26	RNAi	RNAi	NNP
cord-263157-8jin6oru	90	27	machinery	machinery	NN
cord-263157-8jin6oru	90	28	could	could	MD
cord-263157-8jin6oru	90	29	significantly	significantly	RB
cord-263157-8jin6oru	90	30	contribute	contribute	VB
cord-263157-8jin6oru	90	31	to	to	IN
cord-263157-8jin6oru	90	32	the	the	DT
cord-263157-8jin6oru	90	33	design	design	NN
cord-263157-8jin6oru	90	34	of	of	IN
cord-263157-8jin6oru	90	35	an	an	DT
cord-263157-8jin6oru	90	36	effective	effective	JJ
cord-263157-8jin6oru	90	37	RNAi	RNAi	NNS
cord-263157-8jin6oru	90	38	-	-	HYPH
cord-263157-8jin6oru	90	39	based	base	VBN
cord-263157-8jin6oru	90	40	therapy	therapy	NN
cord-263157-8jin6oru	90	41	.	.	.
cord-263157-8jin6oru	91	1	RNAi	RNAi	NNP
cord-263157-8jin6oru	91	2	constitutes	constitute	VBZ
cord-263157-8jin6oru	91	3	a	a	DT
cord-263157-8jin6oru	91	4	key	key	JJ
cord-263157-8jin6oru	91	5	component	component	NN
cord-263157-8jin6oru	91	6	of	of	IN
cord-263157-8jin6oru	91	7	the	the	DT
cord-263157-8jin6oru	91	8	innate	innate	JJ
cord-263157-8jin6oru	91	9	immune	immune	JJ
cord-263157-8jin6oru	91	10	response	response	NN
cord-263157-8jin6oru	91	11	to	to	IN
cord-263157-8jin6oru	91	12	viral	viral	JJ
cord-263157-8jin6oru	91	13	infection	infection	NN
cord-263157-8jin6oru	91	14	in	in	IN
cord-263157-8jin6oru	91	15	both	both	DT
cord-263157-8jin6oru	91	16	plants	plant	NNS
cord-263157-8jin6oru	91	17	and	and	CC
cord-263157-8jin6oru	91	18	invertebrate	invertebrate	JJ
cord-263157-8jin6oru	91	19	animals	animal	NNS
cord-263157-8jin6oru	91	20	(	(	-LRB-
cord-263157-8jin6oru	91	21	39	39	CD
cord-263157-8jin6oru	91	22	)	)	-RRB-
cord-263157-8jin6oru	91	23	,	,	,
cord-263157-8jin6oru	91	24	and	and	CC
cord-263157-8jin6oru	91	25	has	have	VBZ
cord-263157-8jin6oru	91	26	been	be	VBN
cord-263157-8jin6oru	91	27	postulated	postulate	VBN
cord-263157-8jin6oru	91	28	to	to	TO
cord-263157-8jin6oru	91	29	have	have	VB
cord-263157-8jin6oru	91	30	a	a	DT
cord-263157-8jin6oru	91	31	similar	similar	JJ
cord-263157-8jin6oru	91	32	protective	protective	JJ
cord-263157-8jin6oru	91	33	function	function	NN
cord-263157-8jin6oru	91	34	in	in	IN
cord-263157-8jin6oru	91	35	mammals	mammal	NNS
cord-263157-8jin6oru	91	36	(	(	-LRB-
cord-263157-8jin6oru	91	37	40	40	CD
cord-263157-8jin6oru	91	38	)	)	-RRB-
cord-263157-8jin6oru	91	39	.	.	.
cord-263157-8jin6oru	92	1	In	in	IN
cord-263157-8jin6oru	92	2	plants	plant	NNS
cord-263157-8jin6oru	92	3	and	and	CC
cord-263157-8jin6oru	92	4	invertebrate	invertebrate	JJ
cord-263157-8jin6oru	92	5	animals	animal	NNS
cord-263157-8jin6oru	92	6	,	,	,
cord-263157-8jin6oru	92	7	long	long	RB
cord-263157-8jin6oru	92	8	dsRNA	dsrna	NN
cord-263157-8jin6oru	92	9	serves	serve	VBZ
cord-263157-8jin6oru	92	10	as	as	IN
cord-263157-8jin6oru	92	11	the	the	DT
cord-263157-8jin6oru	92	12	initial	initial	JJ
cord-263157-8jin6oru	92	13	trigger	trigger	NN
cord-263157-8jin6oru	92	14	for	for	IN
cord-263157-8jin6oru	92	15	the	the	DT
cord-263157-8jin6oru	92	16	RNAi	RNAi	NNP
cord-263157-8jin6oru	92	17	mechanism	mechanism	NN
cord-263157-8jin6oru	92	18	;	;	:
cord-263157-8jin6oru	92	19	the	the	DT
cord-263157-8jin6oru	92	20	initial	initial	JJ
cord-263157-8jin6oru	92	21	dsRNA	dsrna	NN
cord-263157-8jin6oru	92	22	is	be	VBZ
cord-263157-8jin6oru	92	23	then	then	RB
cord-263157-8jin6oru	92	24	processed	process	VBN
cord-263157-8jin6oru	92	25	by	by	IN
cord-263157-8jin6oru	92	26	Dicer	Dicer	NNP
cord-263157-8jin6oru	92	27	into	into	IN
cord-263157-8jin6oru	92	28	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	92	29	.	.	.
cord-263157-8jin6oru	93	1	However	however	RB
cord-263157-8jin6oru	93	2	,	,	,
cord-263157-8jin6oru	93	3	in	in	IN
cord-263157-8jin6oru	93	4	mammalian	mammalian	JJ
cord-263157-8jin6oru	93	5	cells	cell	NNS
cord-263157-8jin6oru	93	6	,	,	,
cord-263157-8jin6oru	93	7	long	long	JJ
cord-263157-8jin6oru	93	8	dsRNA	dsrna	NN
cord-263157-8jin6oru	93	9	sequences	sequence	NNS
cord-263157-8jin6oru	93	10	(	(	-LRB-
cord-263157-8jin6oru	93	11	more	more	JJR
cord-263157-8jin6oru	93	12	than	than	IN
cord-263157-8jin6oru	93	13	30	30	CD
cord-263157-8jin6oru	93	14	bp	bp	NN
cord-263157-8jin6oru	93	15	in	in	IN
cord-263157-8jin6oru	93	16	length	length	NN
cord-263157-8jin6oru	93	17	)	)	-RRB-
cord-263157-8jin6oru	93	18	are	be	VBP
cord-263157-8jin6oru	93	19	potent	potent	JJ
cord-263157-8jin6oru	93	20	inducers	inducer	NNS
cord-263157-8jin6oru	93	21	of	of	IN
cord-263157-8jin6oru	93	22	the	the	DT
cord-263157-8jin6oru	93	23	interferon	interferon	NN
cord-263157-8jin6oru	93	24	(	(	-LRB-
cord-263157-8jin6oru	93	25	IFN	IFN	NNP
cord-263157-8jin6oru	93	26	)	)	-RRB-
cord-263157-8jin6oru	93	27	response	response	NN
cord-263157-8jin6oru	93	28	(	(	-LRB-
cord-263157-8jin6oru	93	29	41	41	CD
cord-263157-8jin6oru	93	30	)	)	-RRB-
cord-263157-8jin6oru	93	31	.	.	.
cord-263157-8jin6oru	94	1	It	-PRON-	PRP
cord-263157-8jin6oru	94	2	remains	remain	VBZ
cord-263157-8jin6oru	94	3	unclear	unclear	JJ
cord-263157-8jin6oru	94	4	whether	whether	IN
cord-263157-8jin6oru	94	5	the	the	DT
cord-263157-8jin6oru	94	6	introduction	introduction	NN
cord-263157-8jin6oru	94	7	of	of	IN
cord-263157-8jin6oru	94	8	long	long	JJ
cord-263157-8jin6oru	94	9	dsRNA	dsrna	NN
cord-263157-8jin6oru	94	10	into	into	IN
cord-263157-8jin6oru	94	11	mammalian	mammalian	JJ
cord-263157-8jin6oru	94	12	somatic	somatic	JJ
cord-263157-8jin6oru	94	13	cells	cell	NNS
cord-263157-8jin6oru	94	14	is	be	VBZ
cord-263157-8jin6oru	94	15	capable	capable	JJ
cord-263157-8jin6oru	94	16	of	of	IN
cord-263157-8jin6oru	94	17	resulting	result	VBG
cord-263157-8jin6oru	94	18	in	in	IN
cord-263157-8jin6oru	94	19	the	the	DT
cord-263157-8jin6oru	94	20	production	production	NN
cord-263157-8jin6oru	94	21	of	of	IN
cord-263157-8jin6oru	94	22	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	94	23	(	(	-LRB-
cord-263157-8jin6oru	94	24	39	39	CD
cord-263157-8jin6oru	94	25	)	)	-RRB-
cord-263157-8jin6oru	94	26	.	.	.
cord-263157-8jin6oru	95	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	95	2	,	,	,
cord-263157-8jin6oru	95	3	RNAi	RNAi	NNS
cord-263157-8jin6oru	95	4	can	can	MD
cord-263157-8jin6oru	95	5	be	be	VB
cord-263157-8jin6oru	95	6	induced	induce	VBN
cord-263157-8jin6oru	95	7	in	in	IN
cord-263157-8jin6oru	95	8	mammalian	mammalian	JJ
cord-263157-8jin6oru	95	9	cells	cell	NNS
cord-263157-8jin6oru	95	10	by	by	IN
cord-263157-8jin6oru	95	11	the	the	DT
cord-263157-8jin6oru	95	12	nuclear	nuclear	JJ
cord-263157-8jin6oru	95	13	endogenous	endogenous	JJ
cord-263157-8jin6oru	95	14	expression	expression	NN
cord-263157-8jin6oru	95	15	of	of	IN
cord-263157-8jin6oru	95	16	RNAs	rna	NNS
cord-263157-8jin6oru	95	17	that	that	WDT
cord-263157-8jin6oru	95	18	are	be	VBP
cord-263157-8jin6oru	95	19	intermediates	intermediate	NNS
cord-263157-8jin6oru	95	20	in	in	IN
cord-263157-8jin6oru	95	21	the	the	DT
cord-263157-8jin6oru	95	22	miRNA	miRNA	NNP
cord-263157-8jin6oru	95	23	biogenesis	biogenesis	NN
cord-263157-8jin6oru	95	24	pathway	pathway	NNP
cord-263157-8jin6oru	95	25	(	(	-LRB-
cord-263157-8jin6oru	95	26	i.e.	i.e.	FW
cord-263157-8jin6oru	95	27	,	,	,
cord-263157-8jin6oru	95	28	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	95	29	and	and	CC
cord-263157-8jin6oru	95	30	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	95	31	)	)	-RRB-
cord-263157-8jin6oru	95	32	.	.	.
cord-263157-8jin6oru	96	1	The	the	DT
cord-263157-8jin6oru	96	2	human	human	JJ
cord-263157-8jin6oru	96	3	genome	genome	NN
cord-263157-8jin6oru	96	4	encodes	encode	VBZ
cord-263157-8jin6oru	96	5	several	several	JJ
cord-263157-8jin6oru	96	6	hundred	hundred	CD
cord-263157-8jin6oru	96	7	different	different	JJ
cord-263157-8jin6oru	96	8	miRNA	miRNA	NNP
cord-263157-8jin6oru	96	9	molecules	molecule	NNS
cord-263157-8jin6oru	96	10	that	that	WDT
cord-263157-8jin6oru	96	11	are	be	VBP
cord-263157-8jin6oru	96	12	believed	believe	VBN
cord-263157-8jin6oru	96	13	to	to	TO
cord-263157-8jin6oru	96	14	be	be	VB
cord-263157-8jin6oru	96	15	key	key	JJ
cord-263157-8jin6oru	96	16	players	player	NNS
cord-263157-8jin6oru	96	17	in	in	IN
cord-263157-8jin6oru	96	18	the	the	DT
cord-263157-8jin6oru	96	19	posttranscriptional	posttranscriptional	JJ
cord-263157-8jin6oru	96	20	regulation	regulation	NN
cord-263157-8jin6oru	96	21	of	of	IN
cord-263157-8jin6oru	96	22	many	many	JJ
cord-263157-8jin6oru	96	23	aspects	aspect	NNS
cord-263157-8jin6oru	96	24	of	of	IN
cord-263157-8jin6oru	96	25	cellular	cellular	JJ
cord-263157-8jin6oru	96	26	differentiation	differentiation	NN
cord-263157-8jin6oru	96	27	,	,	,
cord-263157-8jin6oru	96	28	and	and	CC
cord-263157-8jin6oru	96	29	RNAi	RNAi	NNP
cord-263157-8jin6oru	96	30	has	have	VBZ
cord-263157-8jin6oru	96	31	been	be	VBN
cord-263157-8jin6oru	96	32	postulated	postulate	VBN
cord-263157-8jin6oru	96	33	to	to	TO
cord-263157-8jin6oru	96	34	exist	exist	VB
cord-263157-8jin6oru	96	35	in	in	IN
cord-263157-8jin6oru	96	36	mammals	mammal	NNS
cord-263157-8jin6oru	96	37	only	only	RB
cord-263157-8jin6oru	96	38	as	as	IN
cord-263157-8jin6oru	96	39	a	a	DT
cord-263157-8jin6oru	96	40	mechanism	mechanism	NN
cord-263157-8jin6oru	96	41	of	of	IN
cord-263157-8jin6oru	96	42	post	post	JJ
cord-263157-8jin6oru	96	43	-	-	JJ
cord-263157-8jin6oru	96	44	transcriptional	transcriptional	JJ
cord-263157-8jin6oru	96	45	regulation	regulation	NN
cord-263157-8jin6oru	96	46	"	"	``
cord-263157-8jin6oru	96	47	programmed	program	VBN
cord-263157-8jin6oru	96	48	"	"	''
cord-263157-8jin6oru	96	49	by	by	IN
cord-263157-8jin6oru	96	50	endogenously	endogenously	RB
cord-263157-8jin6oru	96	51	encoded	encode	VBN
cord-263157-8jin6oru	96	52	miRNA	miRNA	NNP
cord-263157-8jin6oru	96	53	,	,	,
cord-263157-8jin6oru	96	54	rather	rather	RB
cord-263157-8jin6oru	96	55	than	than	IN
cord-263157-8jin6oru	96	56	being	be	VBG
cord-263157-8jin6oru	96	57	involved	involve	VBN
cord-263157-8jin6oru	96	58	in	in	IN
cord-263157-8jin6oru	96	59	intrinsic	intrinsic	JJ
cord-263157-8jin6oru	96	60	antiviral	antiviral	JJ
cord-263157-8jin6oru	96	61	immunity	immunity	NN
cord-263157-8jin6oru	96	62	(	(	-LRB-
cord-263157-8jin6oru	96	63	39	39	CD
cord-263157-8jin6oru	96	64	)	)	-RRB-
cord-263157-8jin6oru	96	65	.	.	.
cord-263157-8jin6oru	97	1	All	all	DT
cord-263157-8jin6oru	97	2	RNA	RNA	NNP
cord-263157-8jin6oru	97	3	viruses	virus	NNS
cord-263157-8jin6oru	97	4	,	,	,
cord-263157-8jin6oru	97	5	except	except	IN
cord-263157-8jin6oru	97	6	retroviruses	retrovirus	NNS
cord-263157-8jin6oru	97	7	,	,	,
cord-263157-8jin6oru	97	8	produce	produce	VBP
cord-263157-8jin6oru	97	9	long	long	JJ
cord-263157-8jin6oru	97	10	dsRNA	dsrna	NN
cord-263157-8jin6oru	97	11	molecules	molecule	NNS
cord-263157-8jin6oru	97	12	in	in	IN
cord-263157-8jin6oru	97	13	infected	infected	JJ
cord-263157-8jin6oru	97	14	cells	cell	NNS
cord-263157-8jin6oru	97	15	that	that	WDT
cord-263157-8jin6oru	97	16	represent	represent	VBP
cord-263157-8jin6oru	97	17	essential	essential	JJ
cord-263157-8jin6oru	97	18	intermediates	intermediate	NNS
cord-263157-8jin6oru	97	19	in	in	IN
cord-263157-8jin6oru	97	20	genomic	genomic	JJ
cord-263157-8jin6oru	97	21	RNA	rna	NN
cord-263157-8jin6oru	97	22	production	production	NN
cord-263157-8jin6oru	97	23	.	.	.
cord-263157-8jin6oru	98	1	Many	many	JJ
cord-263157-8jin6oru	98	2	DNA	dna	NN
cord-263157-8jin6oru	98	3	viruses	virus	NNS
cord-263157-8jin6oru	98	4	also	also	RB
cord-263157-8jin6oru	98	5	generate	generate	VBP
cord-263157-8jin6oru	98	6	long	long	JJ
cord-263157-8jin6oru	98	7	dsRNA	dsrna	NN
cord-263157-8jin6oru	98	8	,	,	,
cord-263157-8jin6oru	98	9	as	as	IN
cord-263157-8jin6oru	98	10	their	-PRON-	PRP$
cord-263157-8jin6oru	98	11	small	small	JJ
cord-263157-8jin6oru	98	12	packed	pack	VBN
cord-263157-8jin6oru	98	13	genomes	genome	NNS
cord-263157-8jin6oru	98	14	have	have	VBP
cord-263157-8jin6oru	98	15	convergent	convergent	JJ
cord-263157-8jin6oru	98	16	transcription	transcription	NN
cord-263157-8jin6oru	98	17	promoters	promoter	NNS
cord-263157-8jin6oru	98	18	.	.	.
cord-263157-8jin6oru	99	1	Some	some	DT
cord-263157-8jin6oru	99	2	studies	study	NNS
cord-263157-8jin6oru	99	3	have	have	VBP
cord-263157-8jin6oru	99	4	attempted	attempt	VBN
cord-263157-8jin6oru	99	5	to	to	TO
cord-263157-8jin6oru	99	6	identify	identify	VB
cord-263157-8jin6oru	99	7	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	99	8	in	in	IN
cord-263157-8jin6oru	99	9	virus	virus	NN
cord-263157-8jin6oru	99	10	-	-	HYPH
cord-263157-8jin6oru	99	11	infected	infect	VBN
cord-263157-8jin6oru	99	12	human	human	JJ
cord-263157-8jin6oru	99	13	cells	cell	NNS
cord-263157-8jin6oru	99	14	.	.	.
cord-263157-8jin6oru	100	1	Pfeffer	Pfeffer	NNP
cord-263157-8jin6oru	100	2	et	et	NNP
cord-263157-8jin6oru	100	3	al	al	NNP
cord-263157-8jin6oru	100	4	.	.	.
cord-263157-8jin6oru	101	1	(	(	-LRB-
cord-263157-8jin6oru	101	2	42	42	CD
cord-263157-8jin6oru	101	3	)	)	-RRB-
cord-263157-8jin6oru	101	4	failed	fail	VBD
cord-263157-8jin6oru	101	5	to	to	TO
cord-263157-8jin6oru	101	6	identify	identify	VB
cord-263157-8jin6oru	101	7	any	any	DT
cord-263157-8jin6oru	101	8	viral	viral	JJ
cord-263157-8jin6oru	101	9	siRNA	sirna	NN
cord-263157-8jin6oru	101	10	in	in	IN
cord-263157-8jin6oru	101	11	cells	cell	NNS
cord-263157-8jin6oru	101	12	infected	infect	VBN
cord-263157-8jin6oru	101	13	by	by	IN
cord-263157-8jin6oru	101	14	DNA	dna	NN
cord-263157-8jin6oru	101	15	viruses	virus	NNS
cord-263157-8jin6oru	101	16	,	,	,
cord-263157-8jin6oru	101	17	such	such	JJ
cord-263157-8jin6oru	101	18	as	as	IN
cord-263157-8jin6oru	101	19	human	human	JJ
cord-263157-8jin6oru	101	20	cytomegalovirus	cytomegalovirus	NN
cord-263157-8jin6oru	101	21	,	,	,
cord-263157-8jin6oru	101	22	Kaposi	Kaposi	NNP
cord-263157-8jin6oru	101	23	sarcoma	sarcoma	NN
cord-263157-8jin6oru	101	24	-	-	HYPH
cord-263157-8jin6oru	101	25	associated	associate	VBN
cord-263157-8jin6oru	101	26	herpes	herpes	NN
cord-263157-8jin6oru	101	27	virus	virus	NN
cord-263157-8jin6oru	101	28	,	,	,
cord-263157-8jin6oru	101	29	Epstein	Epstein	NNP
cord-263157-8jin6oru	101	30	-	-	HYPH
cord-263157-8jin6oru	101	31	Barr	Barr	NNP
cord-263157-8jin6oru	101	32	virus	virus	NN
cord-263157-8jin6oru	101	33	and	and	CC
cord-263157-8jin6oru	101	34	mouse	mouse	NN
cord-263157-8jin6oru	101	35	herpes	herpes	NN
cord-263157-8jin6oru	101	36	virus	virus	NN
cord-263157-8jin6oru	101	37	,	,	,
cord-263157-8jin6oru	101	38	as	as	RB
cord-263157-8jin6oru	101	39	well	well	RB
cord-263157-8jin6oru	101	40	as	as	IN
cord-263157-8jin6oru	101	41	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	101	42	and	and	CC
cord-263157-8jin6oru	101	43	the	the	DT
cord-263157-8jin6oru	101	44	RNA	RNA	NNP
cord-263157-8jin6oru	101	45	viruses	virus	NNS
cord-263157-8jin6oru	101	46	for	for	IN
cord-263157-8jin6oru	101	47	yellow	yellow	JJ
cord-263157-8jin6oru	101	48	fever	fever	NN
cord-263157-8jin6oru	101	49	and	and	CC
cord-263157-8jin6oru	102	1	hepatitis	hepatitis	NNP
cord-263157-8jin6oru	102	2	C.	C.	NNP
cord-263157-8jin6oru	102	3	This	this	DT
cord-263157-8jin6oru	102	4	report	report	NN
cord-263157-8jin6oru	102	5	,	,	,
cord-263157-8jin6oru	102	6	however	however	RB
cord-263157-8jin6oru	102	7	,	,	,
cord-263157-8jin6oru	102	8	did	do	VBD
cord-263157-8jin6oru	102	9	identify	identify	VB
cord-263157-8jin6oru	102	10	several	several	JJ
cord-263157-8jin6oru	102	11	virally	virally	RB
cord-263157-8jin6oru	102	12	encoded	encode	VBN
cord-263157-8jin6oru	102	13	miRNA	miRNA	NNP
cord-263157-8jin6oru	102	14	molecules	molecule	NNS
cord-263157-8jin6oru	102	15	in	in	IN
cord-263157-8jin6oru	102	16	the	the	DT
cord-263157-8jin6oru	102	17	DNA	dna	NN
cord-263157-8jin6oru	102	18	virus	virus	NN
cord-263157-8jin6oru	102	19	.	.	.
cord-263157-8jin6oru	103	1	In	in	IN
cord-263157-8jin6oru	103	2	contrast	contrast	NN
cord-263157-8jin6oru	103	3	,	,	,
cord-263157-8jin6oru	103	4	Bennasser	Bennasser	NNP
cord-263157-8jin6oru	103	5	et	et	NNP
cord-263157-8jin6oru	103	6	al	al	NNP
cord-263157-8jin6oru	103	7	.	.	.
cord-263157-8jin6oru	104	1	(	(	-LRB-
cord-263157-8jin6oru	104	2	43	43	CD
cord-263157-8jin6oru	104	3	)	)	-RRB-
cord-263157-8jin6oru	104	4	reported	report	VBD
cord-263157-8jin6oru	104	5	that	that	IN
cord-263157-8jin6oru	104	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	104	7	gives	give	VBZ
cord-263157-8jin6oru	104	8	rise	rise	NN
cord-263157-8jin6oru	104	9	to	to	IN
cord-263157-8jin6oru	104	10	an	an	DT
cord-263157-8jin6oru	104	11	siRNA	sirna	NN
cord-263157-8jin6oru	104	12	that	that	WDT
cord-263157-8jin6oru	104	13	can	can	MD
cord-263157-8jin6oru	104	14	inhibit	inhibit	VB
cord-263157-8jin6oru	104	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	104	16	replication	replication	NN
cord-263157-8jin6oru	104	17	,	,	,
cord-263157-8jin6oru	104	18	and	and	CC
cord-263157-8jin6oru	104	19	additionally	additionally	RB
cord-263157-8jin6oru	104	20	proposed	propose	VBD
cord-263157-8jin6oru	104	21	that	that	IN
cord-263157-8jin6oru	104	22	the	the	DT
cord-263157-8jin6oru	104	23	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	104	24	Tat	Tat	NNP
cord-263157-8jin6oru	104	25	protein	protein	NN
cord-263157-8jin6oru	104	26	relieves	relieve	VBZ
cord-263157-8jin6oru	104	27	this	this	DT
cord-263157-8jin6oru	104	28	inhibition	inhibition	NN
cord-263157-8jin6oru	104	29	by	by	IN
cord-263157-8jin6oru	104	30	blocking	block	VBG
cord-263157-8jin6oru	104	31	the	the	DT
cord-263157-8jin6oru	104	32	function	function	NN
cord-263157-8jin6oru	104	33	of	of	IN
cord-263157-8jin6oru	104	34	the	the	DT
cord-263157-8jin6oru	104	35	cellular	cellular	JJ
cord-263157-8jin6oru	104	36	Dicer	dicer	NN
cord-263157-8jin6oru	104	37	,	,	,
cord-263157-8jin6oru	104	38	which	which	WDT
cord-263157-8jin6oru	104	39	plays	play	VBZ
cord-263157-8jin6oru	104	40	a	a	DT
cord-263157-8jin6oru	104	41	key	key	JJ
cord-263157-8jin6oru	104	42	role	role	NN
cord-263157-8jin6oru	104	43	in	in	IN
cord-263157-8jin6oru	104	44	both	both	DT
cord-263157-8jin6oru	104	45	siRNA	siRNA	NNP
cord-263157-8jin6oru	104	46	and	and	CC
cord-263157-8jin6oru	104	47	miRNA	miRNA	NNP
cord-263157-8jin6oru	104	48	biogenesis	biogenesis	NN
cord-263157-8jin6oru	104	49	.	.	.
cord-263157-8jin6oru	105	1	Moreover	moreover	RB
cord-263157-8jin6oru	105	2	,	,	,
cord-263157-8jin6oru	105	3	the	the	DT
cord-263157-8jin6oru	105	4	Ebola	Ebola	NNP
cord-263157-8jin6oru	105	5	virus	virus	NN
cord-263157-8jin6oru	105	6	VP35	VP35	NNP
cord-263157-8jin6oru	105	7	protein	protein	NN
cord-263157-8jin6oru	105	8	has	have	VBZ
cord-263157-8jin6oru	105	9	been	be	VBN
cord-263157-8jin6oru	105	10	shown	show	VBN
cord-263157-8jin6oru	105	11	to	to	TO
cord-263157-8jin6oru	105	12	be	be	VB
cord-263157-8jin6oru	105	13	a	a	DT
cord-263157-8jin6oru	105	14	suppressor	suppressor	NN
cord-263157-8jin6oru	105	15	of	of	IN
cord-263157-8jin6oru	105	16	RNAi	RNAi	NNS
cord-263157-8jin6oru	105	17	in	in	IN
cord-263157-8jin6oru	105	18	mammalian	mammalian	JJ
cord-263157-8jin6oru	105	19	cells	cell	NNS
cord-263157-8jin6oru	105	20	and	and	CC
cord-263157-8jin6oru	105	21	its	-PRON-	PRP$
cord-263157-8jin6oru	105	22	suppressor	suppressor	NN
cord-263157-8jin6oru	105	23	activity	activity	NN
cord-263157-8jin6oru	105	24	is	be	VBZ
cord-263157-8jin6oru	105	25	functionally	functionally	RB
cord-263157-8jin6oru	105	26	equivalent	equivalent	JJ
cord-263157-8jin6oru	105	27	to	to	IN
cord-263157-8jin6oru	105	28	that	that	DT
cord-263157-8jin6oru	105	29	of	of	IN
cord-263157-8jin6oru	105	30	the	the	DT
cord-263157-8jin6oru	105	31	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	105	32	Tat	Tat	NNP
cord-263157-8jin6oru	105	33	protein	protein	NN
cord-263157-8jin6oru	105	34	(	(	-LRB-
cord-263157-8jin6oru	105	35	44	44	CD
cord-263157-8jin6oru	105	36	)	)	-RRB-
cord-263157-8jin6oru	105	37	.	.	.
cord-263157-8jin6oru	106	1	VP35	VP35	NNP
cord-263157-8jin6oru	106	2	can	can	MD
cord-263157-8jin6oru	106	3	replace	replace	VB
cord-263157-8jin6oru	106	4	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	106	5	Tat	Tat	NNP
cord-263157-8jin6oru	106	6	and	and	CC
cord-263157-8jin6oru	106	7	thereby	thereby	RB
cord-263157-8jin6oru	106	8	support	support	VB
cord-263157-8jin6oru	106	9	the	the	DT
cord-263157-8jin6oru	106	10	replication	replication	NN
cord-263157-8jin6oru	106	11	of	of	IN
cord-263157-8jin6oru	106	12	an	an	DT
cord-263157-8jin6oru	106	13	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	106	14	variant	variant	NN
cord-263157-8jin6oru	106	15	deficient	deficient	JJ
cord-263157-8jin6oru	106	16	for	for	IN
cord-263157-8jin6oru	106	17	Tat	Tat	NNP
cord-263157-8jin6oru	106	18	.	.	.
cord-263157-8jin6oru	107	1	These	these	DT
cord-263157-8jin6oru	107	2	results	result	NNS
cord-263157-8jin6oru	107	3	support	support	VBP
cord-263157-8jin6oru	107	4	the	the	DT
cord-263157-8jin6oru	107	5	hypothesis	hypothesis	NN
cord-263157-8jin6oru	107	6	that	that	IN
cord-263157-8jin6oru	107	7	RNAi	RNAi	NNP
cord-263157-8jin6oru	107	8	is	be	VBZ
cord-263157-8jin6oru	107	9	indeed	indeed	RB
cord-263157-8jin6oru	107	10	part	part	NN
cord-263157-8jin6oru	107	11	of	of	IN
cord-263157-8jin6oru	107	12	the	the	DT
cord-263157-8jin6oru	107	13	innate	innate	JJ
cord-263157-8jin6oru	107	14	antiviral	antiviral	JJ
cord-263157-8jin6oru	107	15	response	response	NN
cord-263157-8jin6oru	107	16	in	in	IN
cord-263157-8jin6oru	107	17	mammalian	mammalian	JJ
cord-263157-8jin6oru	107	18	cells	cell	NNS
cord-263157-8jin6oru	107	19	.	.	.
cord-263157-8jin6oru	108	1	However	however	RB
cord-263157-8jin6oru	108	2	,	,	,
cord-263157-8jin6oru	108	3	in	in	IN
cord-263157-8jin6oru	108	4	a	a	DT
cord-263157-8jin6oru	108	5	recent	recent	JJ
cord-263157-8jin6oru	108	6	report	report	NN
cord-263157-8jin6oru	108	7	,	,	,
cord-263157-8jin6oru	108	8	the	the	DT
cord-263157-8jin6oru	108	9	stable	stable	JJ
cord-263157-8jin6oru	108	10	expression	expression	NN
cord-263157-8jin6oru	108	11	of	of	IN
cord-263157-8jin6oru	108	12	physiological	physiological	JJ
cord-263157-8jin6oru	108	13	levels	level	NNS
cord-263157-8jin6oru	108	14	of	of	IN
cord-263157-8jin6oru	108	15	Tat	Tat	NNP
cord-263157-8jin6oru	108	16	did	do	VBD
cord-263157-8jin6oru	108	17	not	not	RB
cord-263157-8jin6oru	108	18	globally	globally	RB
cord-263157-8jin6oru	108	19	inhibit	inhibit	VB
cord-263157-8jin6oru	108	20	miRNA	miRNA	NNP
cord-263157-8jin6oru	108	21	production	production	NN
cord-263157-8jin6oru	108	22	or	or	CC
cord-263157-8jin6oru	108	23	expression	expression	NN
cord-263157-8jin6oru	108	24	in	in	IN
cord-263157-8jin6oru	108	25	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	108	26	infected	infect	VBD
cord-263157-8jin6oru	108	27	human	human	JJ
cord-263157-8jin6oru	108	28	cells	cell	NNS
cord-263157-8jin6oru	108	29	(	(	-LRB-
cord-263157-8jin6oru	108	30	45	45	CD
cord-263157-8jin6oru	108	31	)	)	-RRB-
cord-263157-8jin6oru	108	32	.	.	.
cord-263157-8jin6oru	109	1	Strong	strong	JJ
cord-263157-8jin6oru	109	2	evidence	evidence	NN
cord-263157-8jin6oru	109	3	for	for	IN
cord-263157-8jin6oru	109	4	RNAi	RNAi	NNS
cord-263157-8jin6oru	109	5	as	as	IN
cord-263157-8jin6oru	109	6	part	part	NN
cord-263157-8jin6oru	109	7	of	of	IN
cord-263157-8jin6oru	109	8	the	the	DT
cord-263157-8jin6oru	109	9	antiviral	antiviral	JJ
cord-263157-8jin6oru	109	10	innate	innate	JJ
cord-263157-8jin6oru	109	11	immune	immune	NN
cord-263157-8jin6oru	109	12	in	in	IN
cord-263157-8jin6oru	109	13	plants	plant	NNS
cord-263157-8jin6oru	109	14	comes	come	VBZ
cord-263157-8jin6oru	109	15	from	from	IN
cord-263157-8jin6oru	109	16	the	the	DT
cord-263157-8jin6oru	109	17	demonstration	demonstration	NN
cord-263157-8jin6oru	109	18	that	that	WDT
cord-263157-8jin6oru	109	19	almost	almost	RB
cord-263157-8jin6oru	109	20	all	all	DT
cord-263157-8jin6oru	109	21	plant	plant	NN
cord-263157-8jin6oru	109	22	viruses	virus	NNS
cord-263157-8jin6oru	109	23	encode	encode	VBP
cord-263157-8jin6oru	109	24	one	one	CD
cord-263157-8jin6oru	109	25	or	or	CC
cord-263157-8jin6oru	109	26	more	more	JJR
cord-263157-8jin6oru	109	27	suppressor	suppressor	NN
cord-263157-8jin6oru	109	28	of	of	IN
cord-263157-8jin6oru	109	29	RNA	RNA	NNP
cord-263157-8jin6oru	109	30	silencing	silencing	NN
cord-263157-8jin6oru	109	31	(	(	-LRB-
cord-263157-8jin6oru	109	32	SRS	SRS	NNP
cord-263157-8jin6oru	109	33	)	)	-RRB-
cord-263157-8jin6oru	109	34	proteins	protein	NNS
cord-263157-8jin6oru	109	35	,	,	,
cord-263157-8jin6oru	109	36	which	which	WDT
cord-263157-8jin6oru	109	37	target	target	VBP
cord-263157-8jin6oru	109	38	several	several	JJ
cord-263157-8jin6oru	109	39	key	key	JJ
cord-263157-8jin6oru	109	40	steps	step	NNS
cord-263157-8jin6oru	109	41	in	in	IN
cord-263157-8jin6oru	109	42	the	the	DT
cord-263157-8jin6oru	109	43	RNAi	RNAi	NNP
cord-263157-8jin6oru	109	44	response	response	NN
cord-263157-8jin6oru	109	45	(	(	-LRB-
cord-263157-8jin6oru	109	46	40	40	CD
cord-263157-8jin6oru	109	47	)	)	-RRB-
cord-263157-8jin6oru	109	48	.	.	.
cord-263157-8jin6oru	110	1	Similarly	similarly	RB
cord-263157-8jin6oru	110	2	,	,	,
cord-263157-8jin6oru	110	3	several	several	JJ
cord-263157-8jin6oru	110	4	viruses	virus	NNS
cord-263157-8jin6oru	110	5	that	that	WDT
cord-263157-8jin6oru	110	6	target	target	VBP
cord-263157-8jin6oru	110	7	invertebrates	invertebrate	NNS
cord-263157-8jin6oru	110	8	(	(	-LRB-
cord-263157-8jin6oru	110	9	specifically	specifically	RB
cord-263157-8jin6oru	110	10	nematodes	nematode	NNS
cord-263157-8jin6oru	110	11	and	and	CC
cord-263157-8jin6oru	110	12	insects	insect	NNS
cord-263157-8jin6oru	110	13	)	)	-RRB-
cord-263157-8jin6oru	110	14	also	also	RB
cord-263157-8jin6oru	110	15	encode	encode	VB
cord-263157-8jin6oru	110	16	SRS	SRS	NNP
cord-263157-8jin6oru	110	17	proteins	protein	NNS
cord-263157-8jin6oru	110	18	.	.	.
cord-263157-8jin6oru	111	1	Flock	flock	NN
cord-263157-8jin6oru	111	2	house	house	NN
cord-263157-8jin6oru	111	3	virus	virus	NN
cord-263157-8jin6oru	111	4	,	,	,
cord-263157-8jin6oru	111	5	a	a	DT
cord-263157-8jin6oru	111	6	member	member	NN
cord-263157-8jin6oru	111	7	of	of	IN
cord-263157-8jin6oru	111	8	the	the	DT
cord-263157-8jin6oru	111	9	nodavirus	nodavirus	NNP
cord-263157-8jin6oru	111	10	family	family	NN
cord-263157-8jin6oru	111	11	that	that	WDT
cord-263157-8jin6oru	111	12	infect	infect	VBP
cord-263157-8jin6oru	111	13	both	both	DT
cord-263157-8jin6oru	111	14	insects	insect	NNS
cord-263157-8jin6oru	111	15	and	and	CC
cord-263157-8jin6oru	111	16	vertebrate	vertebrate	JJ
cord-263157-8jin6oru	111	17	cells	cell	NNS
cord-263157-8jin6oru	111	18	,	,	,
cord-263157-8jin6oru	111	19	encodes	encode	VBZ
cord-263157-8jin6oru	111	20	a	a	DT
cord-263157-8jin6oru	111	21	viral	viral	JJ
cord-263157-8jin6oru	111	22	SRS	srs	NN
cord-263157-8jin6oru	111	23	that	that	WDT
cord-263157-8jin6oru	111	24	inhibits	inhibit	VBZ
cord-263157-8jin6oru	111	25	Dicer	dicer	NN
cord-263157-8jin6oru	111	26	function	function	NN
cord-263157-8jin6oru	111	27	(	(	-LRB-
cord-263157-8jin6oru	111	28	46	46	CD
cord-263157-8jin6oru	111	29	)	)	-RRB-
cord-263157-8jin6oru	111	30	.	.	.
cord-263157-8jin6oru	112	1	Further	further	JJ
cord-263157-8jin6oru	112	2	evidence	evidence	NN
cord-263157-8jin6oru	112	3	of	of	IN
cord-263157-8jin6oru	112	4	the	the	DT
cord-263157-8jin6oru	112	5	controversial	controversial	JJ
cord-263157-8jin6oru	112	6	relationship	relationship	NN
cord-263157-8jin6oru	112	7	between	between	IN
cord-263157-8jin6oru	112	8	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	112	9	and	and	CC
cord-263157-8jin6oru	112	10	cellular	cellular	JJ
cord-263157-8jin6oru	112	11	RNAi	RNAi	NNP
cord-263157-8jin6oru	112	12	machinery	machinery	NN
cord-263157-8jin6oru	112	13	comes	come	VBZ
cord-263157-8jin6oru	112	14	from	from	IN
cord-263157-8jin6oru	112	15	the	the	DT
cord-263157-8jin6oru	112	16	recent	recent	JJ
cord-263157-8jin6oru	112	17	report	report	NN
cord-263157-8jin6oru	112	18	by	by	IN
cord-263157-8jin6oru	112	19	Triboulet	Triboulet	NNP
cord-263157-8jin6oru	112	20	et	et	NNP
cord-263157-8jin6oru	112	21	al	al	NNP
cord-263157-8jin6oru	112	22	.	.	.
cord-263157-8jin6oru	113	1	(	(	-LRB-
cord-263157-8jin6oru	113	2	47	47	CD
cord-263157-8jin6oru	113	3	)	)	-RRB-
cord-263157-8jin6oru	113	4	,	,	,
cord-263157-8jin6oru	113	5	which	which	WDT
cord-263157-8jin6oru	113	6	provides	provide	VBZ
cord-263157-8jin6oru	113	7	evidence	evidence	NN
cord-263157-8jin6oru	113	8	for	for	IN
cord-263157-8jin6oru	113	9	a	a	DT
cord-263157-8jin6oru	113	10	physiological	physiological	JJ
cord-263157-8jin6oru	113	11	role	role	NN
cord-263157-8jin6oru	113	12	of	of	IN
cord-263157-8jin6oru	113	13	the	the	DT
cord-263157-8jin6oru	113	14	miRNA	miRNA	NNP
cord-263157-8jin6oru	113	15	-	-	HYPH
cord-263157-8jin6oru	113	16	silencing	silence	VBG
cord-263157-8jin6oru	113	17	machinery	machinery	NN
cord-263157-8jin6oru	113	18	in	in	IN
cord-263157-8jin6oru	113	19	controlling	control	VBG
cord-263157-8jin6oru	113	20	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	113	21	replication	replication	NN
cord-263157-8jin6oru	113	22	.	.	.
cord-263157-8jin6oru	114	1	This	this	DT
cord-263157-8jin6oru	114	2	study	study	NN
cord-263157-8jin6oru	114	3	showed	show	VBD
cord-263157-8jin6oru	114	4	that	that	IN
cord-263157-8jin6oru	114	5	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	114	6	infection	infection	NN
cord-263157-8jin6oru	114	7	and	and	CC
cord-263157-8jin6oru	114	8	replication	replication	NN
cord-263157-8jin6oru	114	9	were	be	VBD
cord-263157-8jin6oru	114	10	more	more	RBR
cord-263157-8jin6oru	114	11	efficient	efficient	JJ
cord-263157-8jin6oru	114	12	in	in	IN
cord-263157-8jin6oru	114	13	peripheral	peripheral	JJ
cord-263157-8jin6oru	114	14	blood	blood	NN
cord-263157-8jin6oru	114	15	mononuclear	mononuclear	NN
cord-263157-8jin6oru	114	16	cells	cell	NNS
cord-263157-8jin6oru	114	17	from	from	IN
cord-263157-8jin6oru	114	18	HIV-1-infected	hiv-1-infecte	VBN
cord-263157-8jin6oru	114	19	donors	donor	NNS
cord-263157-8jin6oru	114	20	and	and	CC
cord-263157-8jin6oru	114	21	latently	latently	RB
cord-263157-8jin6oru	114	22	infected	infected	JJ
cord-263157-8jin6oru	114	23	cells	cell	NNS
cord-263157-8jin6oru	114	24	knocked	knock	VBD
cord-263157-8jin6oru	114	25	-	-	HYPH
cord-263157-8jin6oru	114	26	down	down	NN
cord-263157-8jin6oru	114	27	for	for	IN
cord-263157-8jin6oru	114	28	Dicer	Dicer	NNP
cord-263157-8jin6oru	114	29	or	or	CC
cord-263157-8jin6oru	114	30	Drosha	Drosha	NNP
cord-263157-8jin6oru	114	31	,	,	,
cord-263157-8jin6oru	114	32	a	a	DT
cord-263157-8jin6oru	114	33	miRNA	miRNA	NNP
cord-263157-8jin6oru	114	34	processing	processing	NN
cord-263157-8jin6oru	114	35	factor	factor	NN
cord-263157-8jin6oru	114	36	.	.	.
cord-263157-8jin6oru	115	1	Moreover	moreover	RB
cord-263157-8jin6oru	115	2	,	,	,
cord-263157-8jin6oru	115	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	115	4	actively	actively	RB
cord-263157-8jin6oru	115	5	suppressed	suppress	VBD
cord-263157-8jin6oru	115	6	the	the	DT
cord-263157-8jin6oru	115	7	expression	expression	NN
cord-263157-8jin6oru	115	8	of	of	IN
cord-263157-8jin6oru	115	9	the	the	DT
cord-263157-8jin6oru	115	10	polycistronic	polycistronic	NNP
cord-263157-8jin6oru	115	11	miRNA	miRNA	NNP
cord-263157-8jin6oru	115	12	cluster	cluster	NN
cord-263157-8jin6oru	115	13	miR-17/92	miR-17/92	NNP
cord-263157-8jin6oru	115	14	,	,	,
cord-263157-8jin6oru	115	15	and	and	CC
cord-263157-8jin6oru	115	16	this	this	DT
cord-263157-8jin6oru	115	17	suppression	suppression	NN
cord-263157-8jin6oru	115	18	was	be	VBD
cord-263157-8jin6oru	115	19	found	find	VBN
cord-263157-8jin6oru	115	20	to	to	TO
cord-263157-8jin6oru	115	21	be	be	VB
cord-263157-8jin6oru	115	22	required	require	VBN
cord-263157-8jin6oru	115	23	for	for	IN
cord-263157-8jin6oru	115	24	efficient	efficient	JJ
cord-263157-8jin6oru	115	25	viral	viral	JJ
cord-263157-8jin6oru	115	26	replication	replication	NN
cord-263157-8jin6oru	115	27	.	.	.
cord-263157-8jin6oru	116	1	As	as	IN
cord-263157-8jin6oru	116	2	suggested	suggest	VBN
cord-263157-8jin6oru	116	3	in	in	IN
cord-263157-8jin6oru	116	4	this	this	DT
cord-263157-8jin6oru	116	5	study	study	NN
cord-263157-8jin6oru	116	6	,	,	,
cord-263157-8jin6oru	116	7	these	these	DT
cord-263157-8jin6oru	116	8	findings	finding	NNS
cord-263157-8jin6oru	116	9	may	may	MD
cord-263157-8jin6oru	116	10	help	help	VB
cord-263157-8jin6oru	116	11	address	address	VB
cord-263157-8jin6oru	116	12	the	the	DT
cord-263157-8jin6oru	116	13	current	current	JJ
cord-263157-8jin6oru	116	14	challenge	challenge	NN
cord-263157-8jin6oru	116	15	of	of	IN
cord-263157-8jin6oru	116	16	how	how	WRB
cord-263157-8jin6oru	116	17	to	to	TO
cord-263157-8jin6oru	116	18	activate	activate	VB
cord-263157-8jin6oru	116	19	latent	latent	JJ
cord-263157-8jin6oru	116	20	viral	viral	JJ
cord-263157-8jin6oru	116	21	reservoirs	reservoir	NNS
cord-263157-8jin6oru	116	22	in	in	IN
cord-263157-8jin6oru	116	23	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	116	24	therapy	therapy	NN
cord-263157-8jin6oru	116	25	.	.	.
cord-263157-8jin6oru	117	1	Virally	Virally	NNP
cord-263157-8jin6oru	117	2	encoded	encode	VBD
cord-263157-8jin6oru	117	3	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	117	4	have	have	VBP
cord-263157-8jin6oru	117	5	been	be	VBN
cord-263157-8jin6oru	117	6	discovered	discover	VBN
cord-263157-8jin6oru	117	7	in	in	IN
cord-263157-8jin6oru	117	8	herpes	herpes	NN
cord-263157-8jin6oru	117	9	viruses	virus	NNS
cord-263157-8jin6oru	117	10	(	(	-LRB-
cord-263157-8jin6oru	117	11	39	39	CD
cord-263157-8jin6oru	117	12	)	)	-RRB-
cord-263157-8jin6oru	117	13	,	,	,
cord-263157-8jin6oru	117	14	and	and	CC
cord-263157-8jin6oru	117	15	human	human	JJ
cord-263157-8jin6oru	117	16	cytomegalovirus	cytomegalovirus	NN
cord-263157-8jin6oru	117	17	has	have	VBZ
cord-263157-8jin6oru	117	18	been	be	VBN
cord-263157-8jin6oru	117	19	shown	show	VBN
cord-263157-8jin6oru	117	20	to	to	TO
cord-263157-8jin6oru	117	21	evade	evade	VB
cord-263157-8jin6oru	117	22	the	the	DT
cord-263157-8jin6oru	117	23	host	host	NN
cord-263157-8jin6oru	117	24	immune	immune	JJ
cord-263157-8jin6oru	117	25	system	system	NN
cord-263157-8jin6oru	117	26	by	by	IN
cord-263157-8jin6oru	117	27	targeting	target	VBG
cord-263157-8jin6oru	117	28	host	host	NN
cord-263157-8jin6oru	117	29	genes	gene	NNS
cord-263157-8jin6oru	117	30	with	with	IN
cord-263157-8jin6oru	117	31	virally	virally	RB
cord-263157-8jin6oru	117	32	encoded	encode	VBN
cord-263157-8jin6oru	117	33	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	117	34	(	(	-LRB-
cord-263157-8jin6oru	117	35	48	48	CD
cord-263157-8jin6oru	117	36	)	)	-RRB-
cord-263157-8jin6oru	117	37	.	.	.
cord-263157-8jin6oru	118	1	Whether	whether	IN
cord-263157-8jin6oru	118	2	RNA	RNA	NNP
cord-263157-8jin6oru	118	3	viruses	virus	NNS
cord-263157-8jin6oru	118	4	,	,	,
cord-263157-8jin6oru	118	5	including	include	VBG
cord-263157-8jin6oru	118	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	118	7	,	,	,
cord-263157-8jin6oru	118	8	encode	encode	VB
cord-263157-8jin6oru	118	9	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	118	10	still	still	RB
cord-263157-8jin6oru	118	11	remains	remain	VBZ
cord-263157-8jin6oru	118	12	controversial	controversial	JJ
cord-263157-8jin6oru	118	13	(	(	-LRB-
cord-263157-8jin6oru	118	14	48	48	CD
cord-263157-8jin6oru	118	15	)	)	-RRB-
cord-263157-8jin6oru	118	16	.	.	.
cord-263157-8jin6oru	119	1	The	the	DT
cord-263157-8jin6oru	119	2	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	119	3	implications	implication	NNS
cord-263157-8jin6oru	119	4	of	of	IN
cord-263157-8jin6oru	119	5	this	this	DT
cord-263157-8jin6oru	119	6	molecular	molecular	JJ
cord-263157-8jin6oru	119	7	feature	feature	NN
cord-263157-8jin6oru	119	8	are	be	VBP
cord-263157-8jin6oru	119	9	intriguing	intriguing	JJ
cord-263157-8jin6oru	119	10	,	,	,
cord-263157-8jin6oru	119	11	as	as	IN
cord-263157-8jin6oru	119	12	targeting	target	VBG
cord-263157-8jin6oru	119	13	these	these	DT
cord-263157-8jin6oru	119	14	viral	viral	JJ
cord-263157-8jin6oru	119	15	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	119	16	might	may	MD
cord-263157-8jin6oru	119	17	constitute	constitute	VB
cord-263157-8jin6oru	119	18	an	an	DT
cord-263157-8jin6oru	119	19	antiviral	antiviral	JJ
cord-263157-8jin6oru	119	20	therapy	therapy	NN
cord-263157-8jin6oru	119	21	while	while	IN
cord-263157-8jin6oru	119	22	mimicking	mimic	VBG
cord-263157-8jin6oru	119	23	their	-PRON-	PRP$
cord-263157-8jin6oru	119	24	role	role	NN
cord-263157-8jin6oru	119	25	could	could	MD
cord-263157-8jin6oru	119	26	provide	provide	VB
cord-263157-8jin6oru	119	27	a	a	DT
cord-263157-8jin6oru	119	28	means	means	NN
cord-263157-8jin6oru	119	29	of	of	IN
cord-263157-8jin6oru	119	30	immunosuppressive	immunosuppressive	JJ
cord-263157-8jin6oru	119	31	therapy	therapy	NN
cord-263157-8jin6oru	119	32	(	(	-LRB-
cord-263157-8jin6oru	119	33	48	48	CD
cord-263157-8jin6oru	119	34	)	)	-RRB-
cord-263157-8jin6oru	119	35	.	.	.
cord-263157-8jin6oru	120	1	Latent	latent	JJ
cord-263157-8jin6oru	120	2	infection	infection	NN
cord-263157-8jin6oru	120	3	is	be	VBZ
cord-263157-8jin6oru	120	4	one	one	CD
cord-263157-8jin6oru	120	5	of	of	IN
cord-263157-8jin6oru	120	6	the	the	DT
cord-263157-8jin6oru	120	7	most	most	RBS
cord-263157-8jin6oru	120	8	important	important	JJ
cord-263157-8jin6oru	120	9	characteristics	characteristic	NNS
cord-263157-8jin6oru	120	10	required	require	VBN
cord-263157-8jin6oru	120	11	for	for	IN
cord-263157-8jin6oru	120	12	the	the	DT
cord-263157-8jin6oru	120	13	in	in	IN
cord-263157-8jin6oru	120	14	vivo	vivo	NN
cord-263157-8jin6oru	120	15	survival	survival	NN
cord-263157-8jin6oru	120	16	of	of	IN
cord-263157-8jin6oru	120	17	all	all	DT
cord-263157-8jin6oru	120	18	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	120	19	strains	strain	NNS
cord-263157-8jin6oru	120	20	and	and	CC
cord-263157-8jin6oru	120	21	the	the	DT
cord-263157-8jin6oru	120	22	major	major	JJ
cord-263157-8jin6oru	120	23	obstacle	obstacle	NN
cord-263157-8jin6oru	120	24	in	in	IN
cord-263157-8jin6oru	120	25	eradicating	eradicate	VBG
cord-263157-8jin6oru	120	26	virus	virus	NN
cord-263157-8jin6oru	120	27	infection	infection	NN
cord-263157-8jin6oru	120	28	with	with	IN
cord-263157-8jin6oru	120	29	HAART	HAART	NNP
cord-263157-8jin6oru	120	30	(	(	-LRB-
cord-263157-8jin6oru	120	31	7	7	CD
cord-263157-8jin6oru	120	32	-	-	SYM
cord-263157-8jin6oru	120	33	10	10	CD
cord-263157-8jin6oru	120	34	)	)	-RRB-
cord-263157-8jin6oru	120	35	.	.	.
cord-263157-8jin6oru	121	1	A	a	DT
cord-263157-8jin6oru	121	2	recent	recent	JJ
cord-263157-8jin6oru	121	3	study	study	NN
cord-263157-8jin6oru	121	4	showed	show	VBD
cord-263157-8jin6oru	121	5	that	that	IN
cord-263157-8jin6oru	121	6	cellular	cellular	JJ
cord-263157-8jin6oru	121	7	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	121	8	potently	potently	RB
cord-263157-8jin6oru	121	9	inhibit	inhibit	VBP
cord-263157-8jin6oru	121	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	121	11	production	production	NN
cord-263157-8jin6oru	121	12	in	in	IN
cord-263157-8jin6oru	121	13	resting	rest	VBG
cord-263157-8jin6oru	121	14	primary	primary	JJ
cord-263157-8jin6oru	121	15	CD4	CD4	NNP
cord-263157-8jin6oru	121	16	+	+	CC
cord-263157-8jin6oru	121	17	T	T	NNP
cord-263157-8jin6oru	121	18	cells	cell	NNS
cord-263157-8jin6oru	121	19	(	(	-LRB-
cord-263157-8jin6oru	121	20	49	49	CD
cord-263157-8jin6oru	121	21	)	)	-RRB-
cord-263157-8jin6oru	121	22	;	;	:
cord-263157-8jin6oru	121	23	the	the	DT
cord-263157-8jin6oru	121	24	3	3	CD
cord-263157-8jin6oru	121	25	′	′	CD
cord-263157-8jin6oru	121	26	ends	end	NNS
cord-263157-8jin6oru	121	27	of	of	IN
cord-263157-8jin6oru	122	1	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	122	2	mRNAs	mRNAs	NNPS
cord-263157-8jin6oru	122	3	were	be	VBD
cord-263157-8jin6oru	122	4	found	find	VBN
cord-263157-8jin6oru	122	5	to	to	TO
cord-263157-8jin6oru	122	6	be	be	VB
cord-263157-8jin6oru	122	7	targeted	target	VBN
cord-263157-8jin6oru	122	8	by	by	IN
cord-263157-8jin6oru	122	9	a	a	DT
cord-263157-8jin6oru	122	10	cluster	cluster	NN
cord-263157-8jin6oru	122	11	of	of	IN
cord-263157-8jin6oru	122	12	cellular	cellular	JJ
cord-263157-8jin6oru	122	13	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	122	14	including	include	VBG
cord-263157-8jin6oru	122	15	miR-28	miR-28	NNP
cord-263157-8jin6oru	122	16	,	,	,
cord-263157-8jin6oru	122	17	miR-125b	mir-125b	CD
cord-263157-8jin6oru	122	18	,	,	,
cord-263157-8jin6oru	122	19	miR-150	miR-150	NNP
cord-263157-8jin6oru	122	20	,	,	,
cord-263157-8jin6oru	122	21	miR-223	miR-223	NNP
cord-263157-8jin6oru	122	22	and	and	CC
cord-263157-8jin6oru	122	23	miR-382	miR-382	NNP
cord-263157-8jin6oru	122	24	,	,	,
cord-263157-8jin6oru	122	25	which	which	WDT
cord-263157-8jin6oru	122	26	are	be	VBP
cord-263157-8jin6oru	122	27	enriched	enrich	VBN
cord-263157-8jin6oru	122	28	in	in	IN
cord-263157-8jin6oru	122	29	resting	rest	VBG
cord-263157-8jin6oru	122	30	CD4	CD4	NNP
cord-263157-8jin6oru	122	31	+	+	CC
cord-263157-8jin6oru	122	32	T	t	NN
cord-263157-8jin6oru	122	33	cells	cell	NNS
cord-263157-8jin6oru	122	34	compared	compare	VBN
cord-263157-8jin6oru	122	35	to	to	IN
cord-263157-8jin6oru	122	36	activated	activate	VBN
cord-263157-8jin6oru	122	37	CD4	CD4	NNP
cord-263157-8jin6oru	122	38	+	+	CC
cord-263157-8jin6oru	122	39	T	t	NN
cord-263157-8jin6oru	122	40	cells	cell	NNS
cord-263157-8jin6oru	122	41	(	(	-LRB-
cord-263157-8jin6oru	122	42	see	see	VB
cord-263157-8jin6oru	122	43	Chap	Chap	NNP
cord-263157-8jin6oru	122	44	.	.	.
cord-263157-8jin6oru	123	1	20	20	CD
cord-263157-8jin6oru	123	2	)	)	-RRB-
cord-263157-8jin6oru	123	3	.	.	.
cord-263157-8jin6oru	124	1	Because	because	IN
cord-263157-8jin6oru	124	2	specific	specific	JJ
cord-263157-8jin6oru	124	3	inhibitors	inhibitor	NNS
cord-263157-8jin6oru	124	4	of	of	IN
cord-263157-8jin6oru	124	5	these	these	DT
cord-263157-8jin6oru	124	6	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	124	7	substantially	substantially	RB
cord-263157-8jin6oru	124	8	counteracted	counteract	VBD
cord-263157-8jin6oru	124	9	their	-PRON-	PRP$
cord-263157-8jin6oru	124	10	effects	effect	NNS
cord-263157-8jin6oru	124	11	on	on	IN
cord-263157-8jin6oru	124	12	the	the	DT
cord-263157-8jin6oru	124	13	target	target	NN
cord-263157-8jin6oru	124	14	mRNAs	mRNAs	''
cord-263157-8jin6oru	124	15	(	(	-LRB-
cord-263157-8jin6oru	124	16	49	49	CD
cord-263157-8jin6oru	124	17	)	)	-RRB-
cord-263157-8jin6oru	124	18	,	,	,
cord-263157-8jin6oru	124	19	a	a	DT
cord-263157-8jin6oru	124	20	combined	combine	VBN
cord-263157-8jin6oru	124	21	miRNA	miRNA	NNP
cord-263157-8jin6oru	124	22	inhibitor	inhibitor	NN
cord-263157-8jin6oru	124	23	panel	panel	NN
cord-263157-8jin6oru	124	24	could	could	MD
cord-263157-8jin6oru	124	25	be	be	VB
cord-263157-8jin6oru	124	26	used	use	VBN
cord-263157-8jin6oru	124	27	to	to	TO
cord-263157-8jin6oru	124	28	activate	activate	VB
cord-263157-8jin6oru	124	29	latent	latent	JJ
cord-263157-8jin6oru	124	30	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	124	31	for	for	IN
cord-263157-8jin6oru	124	32	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	124	33	purposes	purpose	NNS
cord-263157-8jin6oru	124	34	.	.	.
cord-263157-8jin6oru	125	1	In	in	IN
cord-263157-8jin6oru	125	2	agreement	agreement	NN
cord-263157-8jin6oru	125	3	with	with	IN
cord-263157-8jin6oru	125	4	the	the	DT
cord-263157-8jin6oru	125	5	former	former	JJ
cord-263157-8jin6oru	125	6	report	report	NN
cord-263157-8jin6oru	125	7	,	,	,
cord-263157-8jin6oru	125	8	the	the	DT
cord-263157-8jin6oru	125	9	cellular	cellular	JJ
cord-263157-8jin6oru	125	10	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	125	11	miR-196	miR-196	NNS
cord-263157-8jin6oru	125	12	,	,	,
cord-263157-8jin6oru	125	13	miR-296	miR-296	NNP
cord-263157-8jin6oru	125	14	,	,	,
cord-263157-8jin6oru	125	15	miR-351	miR-351	NNP
cord-263157-8jin6oru	125	16	,	,	,
cord-263157-8jin6oru	125	17	miR-431	miR-431	NNP
cord-263157-8jin6oru	125	18	and	and	CC
cord-263157-8jin6oru	125	19	miR-448	miR-448	NNS
cord-263157-8jin6oru	125	20	have	have	VBP
cord-263157-8jin6oru	125	21	been	be	VBN
cord-263157-8jin6oru	125	22	shown	show	VBN
cord-263157-8jin6oru	125	23	to	to	TO
cord-263157-8jin6oru	125	24	be	be	VB
cord-263157-8jin6oru	125	25	capable	capable	JJ
cord-263157-8jin6oru	125	26	of	of	IN
cord-263157-8jin6oru	125	27	inhibiting	inhibit	VBG
cord-263157-8jin6oru	125	28	hepatitis	hepatitis	NN
cord-263157-8jin6oru	125	29	C	C	NNP
cord-263157-8jin6oru	125	30	virus	virus	NN
cord-263157-8jin6oru	125	31	replication	replication	NN
cord-263157-8jin6oru	125	32	and	and	CC
cord-263157-8jin6oru	125	33	infection	infection	NN
cord-263157-8jin6oru	125	34	(	(	-LRB-
cord-263157-8jin6oru	125	35	50	50	CD
cord-263157-8jin6oru	125	36	)	)	-RRB-
cord-263157-8jin6oru	125	37	.	.	.
cord-263157-8jin6oru	126	1	These	these	DT
cord-263157-8jin6oru	126	2	miRNAs	mirna	NNS
cord-263157-8jin6oru	126	3	are	be	VBP
cord-263157-8jin6oru	126	4	upregulated	upregulate	VBN
cord-263157-8jin6oru	126	5	by	by	IN
cord-263157-8jin6oru	126	6	IFN	IFN	NNP
cord-263157-8jin6oru	126	7	α	α	NNP
cord-263157-8jin6oru	126	8	/	/	SYM
cord-263157-8jin6oru	126	9	β	β	NN
cord-263157-8jin6oru	126	10	,	,	,
cord-263157-8jin6oru	126	11	suggesting	suggest	VBG
cord-263157-8jin6oru	126	12	that	that	IN
cord-263157-8jin6oru	126	13	cellular	cellular	JJ
cord-263157-8jin6oru	126	14	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	126	15	may	may	MD
cord-263157-8jin6oru	126	16	be	be	VB
cord-263157-8jin6oru	126	17	components	component	NNS
cord-263157-8jin6oru	126	18	of	of	IN
cord-263157-8jin6oru	126	19	the	the	DT
cord-263157-8jin6oru	126	20	mammalian	mammalian	JJ
cord-263157-8jin6oru	126	21	innate	innate	JJ
cord-263157-8jin6oru	126	22	immune	immune	JJ
cord-263157-8jin6oru	126	23	response	response	NN
cord-263157-8jin6oru	126	24	(	(	-LRB-
cord-263157-8jin6oru	126	25	50	50	CD
cord-263157-8jin6oru	126	26	)	)	-RRB-
cord-263157-8jin6oru	126	27	.	.	.
cord-263157-8jin6oru	127	1	This	this	DT
cord-263157-8jin6oru	127	2	review	review	NN
cord-263157-8jin6oru	127	3	highlights	highlight	VBZ
cord-263157-8jin6oru	127	4	the	the	DT
cord-263157-8jin6oru	127	5	evidence	evidence	NN
cord-263157-8jin6oru	127	6	showing	show	VBG
cord-263157-8jin6oru	127	7	that	that	IN
cord-263157-8jin6oru	127	8	RNAi	RNAi	NNP
cord-263157-8jin6oru	127	9	provides	provide	VBZ
cord-263157-8jin6oru	127	10	a	a	DT
cord-263157-8jin6oru	127	11	robust	robust	JJ
cord-263157-8jin6oru	127	12	method	method	NN
cord-263157-8jin6oru	127	13	for	for	IN
cord-263157-8jin6oru	127	14	specifically	specifically	RB
cord-263157-8jin6oru	127	15	inhibiting	inhibit	VBG
cord-263157-8jin6oru	127	16	the	the	DT
cord-263157-8jin6oru	127	17	expression	expression	NN
cord-263157-8jin6oru	127	18	of	of	IN
cord-263157-8jin6oru	127	19	targeted	target	VBN
cord-263157-8jin6oru	127	20	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	127	21	genes	gene	NNS
cord-263157-8jin6oru	127	22	,	,	,
cord-263157-8jin6oru	127	23	and	and	CC
cord-263157-8jin6oru	127	24	its	-PRON-	PRP$
cord-263157-8jin6oru	127	25	promise	promise	NN
cord-263157-8jin6oru	127	26	as	as	IN
cord-263157-8jin6oru	127	27	a	a	DT
cord-263157-8jin6oru	127	28	novel	novel	NN
cord-263157-8jin6oru	127	29	and	and	CC
cord-263157-8jin6oru	127	30	broadly	broadly	RB
cord-263157-8jin6oru	127	31	applicable	applicable	JJ
cord-263157-8jin6oru	127	32	approach	approach	NN
cord-263157-8jin6oru	127	33	to	to	IN
cord-263157-8jin6oru	127	34	antiviral	antiviral	JJ
cord-263157-8jin6oru	127	35	therapy	therapy	NN
cord-263157-8jin6oru	127	36	.	.	.
cord-263157-8jin6oru	128	1	However	however	RB
cord-263157-8jin6oru	128	2	,	,	,
cord-263157-8jin6oru	128	3	clinical	clinical	JJ
cord-263157-8jin6oru	128	4	application	application	NN
cord-263157-8jin6oru	128	5	of	of	IN
cord-263157-8jin6oru	128	6	RNAi	RNAi	NNP
cord-263157-8jin6oru	128	7	faces	face	VBZ
cord-263157-8jin6oru	128	8	several	several	JJ
cord-263157-8jin6oru	128	9	challenges	challenge	NNS
cord-263157-8jin6oru	128	10	,	,	,
cord-263157-8jin6oru	128	11	specifically	specifically	RB
cord-263157-8jin6oru	128	12	the	the	DT
cord-263157-8jin6oru	128	13	potential	potential	NN
cord-263157-8jin6oru	128	14	for	for	IN
cord-263157-8jin6oru	128	15	viral	viral	JJ
cord-263157-8jin6oru	128	16	escape	escape	NN
cord-263157-8jin6oru	128	17	.	.	.
cord-263157-8jin6oru	129	1	One	one	CD
cord-263157-8jin6oru	129	2	of	of	IN
cord-263157-8jin6oru	129	3	the	the	DT
cord-263157-8jin6oru	129	4	main	main	JJ
cord-263157-8jin6oru	129	5	advantages	advantage	NNS
cord-263157-8jin6oru	129	6	of	of	IN
cord-263157-8jin6oru	129	7	the	the	DT
cord-263157-8jin6oru	129	8	RNAi	RNAi	NNP
cord-263157-8jin6oru	129	9	mechanism	mechanism	NN
cord-263157-8jin6oru	129	10	is	be	VBZ
cord-263157-8jin6oru	129	11	that	that	IN
cord-263157-8jin6oru	129	12	it	-PRON-	PRP
cord-263157-8jin6oru	129	13	is	be	VBZ
cord-263157-8jin6oru	129	14	highly	highly	RB
cord-263157-8jin6oru	129	15	sequence	sequence	NN
cord-263157-8jin6oru	129	16	specific	specific	JJ
cord-263157-8jin6oru	129	17	.	.	.
cord-263157-8jin6oru	130	1	Pioneer	Pioneer	NNP
cord-263157-8jin6oru	130	2	studies	study	NNS
cord-263157-8jin6oru	130	3	confirmed	confirm	VBD
cord-263157-8jin6oru	130	4	the	the	DT
cord-263157-8jin6oru	130	5	specificity	specificity	NN
cord-263157-8jin6oru	130	6	of	of	IN
cord-263157-8jin6oru	130	7	RNAi	RNAi	NNS
cord-263157-8jin6oru	130	8	by	by	IN
cord-263157-8jin6oru	130	9	evaluating	evaluate	VBG
cord-263157-8jin6oru	130	10	the	the	DT
cord-263157-8jin6oru	130	11	activity	activity	NN
cord-263157-8jin6oru	130	12	of	of	IN
cord-263157-8jin6oru	130	13	an	an	DT
cord-263157-8jin6oru	130	14	siRNA	sirna	NN
cord-263157-8jin6oru	130	15	with	with	IN
cord-263157-8jin6oru	130	16	one	one	CD
cord-263157-8jin6oru	130	17	or	or	CC
cord-263157-8jin6oru	130	18	more	more	JJR
cord-263157-8jin6oru	130	19	mismatches	mismatch	NNS
cord-263157-8jin6oru	130	20	relative	relative	JJ
cord-263157-8jin6oru	130	21	to	to	IN
cord-263157-8jin6oru	130	22	the	the	DT
cord-263157-8jin6oru	130	23	target	target	NN
cord-263157-8jin6oru	130	24	RNA	RNA	NNP
cord-263157-8jin6oru	130	25	sequence	sequence	NN
cord-263157-8jin6oru	130	26	(	(	-LRB-
cord-263157-8jin6oru	130	27	18	18	CD
cord-263157-8jin6oru	130	28	)	)	-RRB-
cord-263157-8jin6oru	130	29	;	;	:
cord-263157-8jin6oru	130	30	these	these	DT
cord-263157-8jin6oru	130	31	studies	study	NNS
cord-263157-8jin6oru	130	32	showed	show	VBD
cord-263157-8jin6oru	130	33	that	that	IN
cord-263157-8jin6oru	130	34	a	a	DT
cord-263157-8jin6oru	130	35	mismatch	mismatch	NN
cord-263157-8jin6oru	130	36	may	may	MD
cord-263157-8jin6oru	130	37	be	be	VB
cord-263157-8jin6oru	130	38	sufficient	sufficient	JJ
cord-263157-8jin6oru	130	39	to	to	TO
cord-263157-8jin6oru	130	40	reduce	reduce	VB
cord-263157-8jin6oru	130	41	the	the	DT
cord-263157-8jin6oru	130	42	silencing	silencing	NN
cord-263157-8jin6oru	130	43	effect	effect	NN
cord-263157-8jin6oru	130	44	,	,	,
cord-263157-8jin6oru	130	45	suggesting	suggest	VBG
cord-263157-8jin6oru	130	46	that	that	IN
cord-263157-8jin6oru	130	47	an	an	DT
cord-263157-8jin6oru	130	48	unspecific	unspecific	JJ
cord-263157-8jin6oru	130	49	antiviral	antiviral	JJ
cord-263157-8jin6oru	130	50	response	response	NN
cord-263157-8jin6oru	130	51	induced	induce	VBN
cord-263157-8jin6oru	130	52	by	by	IN
cord-263157-8jin6oru	130	53	siRNA	siRNA	NNP
cord-263157-8jin6oru	130	54	was	be	VBD
cord-263157-8jin6oru	130	55	not	not	RB
cord-263157-8jin6oru	130	56	involved	involve	VBN
cord-263157-8jin6oru	130	57	in	in	IN
cord-263157-8jin6oru	130	58	the	the	DT
cord-263157-8jin6oru	130	59	silencing	silencing	NN
cord-263157-8jin6oru	130	60	effect	effect	NN
cord-263157-8jin6oru	130	61	,	,	,
cord-263157-8jin6oru	130	62	but	but	CC
cord-263157-8jin6oru	130	63	also	also	RB
cord-263157-8jin6oru	130	64	showing	show	VBG
cord-263157-8jin6oru	130	65	that	that	IN
cord-263157-8jin6oru	130	66	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	130	67	may	may	MD
cord-263157-8jin6oru	130	68	easily	easily	RB
cord-263157-8jin6oru	130	69	escape	escape	VB
cord-263157-8jin6oru	130	70	inhibition	inhibition	NN
cord-263157-8jin6oru	130	71	by	by	IN
cord-263157-8jin6oru	130	72	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	130	73	.	.	.
cord-263157-8jin6oru	131	1	Indeed	indeed	RB
cord-263157-8jin6oru	131	2	,	,	,
cord-263157-8jin6oru	131	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	131	4	has	have	VBZ
cord-263157-8jin6oru	131	5	been	be	VBN
cord-263157-8jin6oru	131	6	observed	observe	VBN
cord-263157-8jin6oru	131	7	to	to	TO
cord-263157-8jin6oru	131	8	promptly	promptly	RB
cord-263157-8jin6oru	131	9	escape	escape	VB
cord-263157-8jin6oru	131	10	suppression	suppression	NN
cord-263157-8jin6oru	131	11	by	by	IN
cord-263157-8jin6oru	131	12	effective	effective	JJ
cord-263157-8jin6oru	131	13	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	131	14	(	(	-LRB-
cord-263157-8jin6oru	131	15	36	36	CD
cord-263157-8jin6oru	131	16	,	,	,
cord-263157-8jin6oru	131	17	51	51	CD
cord-263157-8jin6oru	131	18	,	,	,
cord-263157-8jin6oru	131	19	52	52	CD
cord-263157-8jin6oru	131	20	)	)	-RRB-
cord-263157-8jin6oru	131	21	.	.	.
cord-263157-8jin6oru	132	1	Unlike	unlike	IN
cord-263157-8jin6oru	132	2	eukaryotic	eukaryotic	JJ
cord-263157-8jin6oru	132	3	DNA	dna	NN
cord-263157-8jin6oru	132	4	polymerases	polymerase	NNS
cord-263157-8jin6oru	132	5	,	,	,
cord-263157-8jin6oru	132	6	the	the	DT
cord-263157-8jin6oru	132	7	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	132	8	RT	RT	NNP
cord-263157-8jin6oru	132	9	lacks	lack	VBZ
cord-263157-8jin6oru	132	10	proofreading	proofreading	NN
cord-263157-8jin6oru	132	11	activity	activity	NN
cord-263157-8jin6oru	132	12	,	,	,
cord-263157-8jin6oru	132	13	and	and	CC
cord-263157-8jin6oru	132	14	its	-PRON-	PRP$
cord-263157-8jin6oru	132	15	error	error	NN
cord-263157-8jin6oru	132	16	rate	rate	NN
cord-263157-8jin6oru	132	17	has	have	VBZ
cord-263157-8jin6oru	132	18	been	be	VBN
cord-263157-8jin6oru	132	19	estimated	estimate	VBN
cord-263157-8jin6oru	132	20	at	at	IN
cord-263157-8jin6oru	132	21	10	10	CD
cord-263157-8jin6oru	132	22	−4	−4	CD
cord-263157-8jin6oru	133	1	to	to	IN
cord-263157-8jin6oru	133	2	10	10	CD
cord-263157-8jin6oru	133	3	−5	−5	NNS
cord-263157-8jin6oru	133	4	mutations	mutation	NNS
cord-263157-8jin6oru	133	5	per	per	IN
cord-263157-8jin6oru	133	6	nucleotide	nucleotide	NN
cord-263157-8jin6oru	133	7	and	and	CC
cord-263157-8jin6oru	133	8	cycle	cycle	NN
cord-263157-8jin6oru	133	9	of	of	IN
cord-263157-8jin6oru	133	10	replication	replication	NN
cord-263157-8jin6oru	134	1	(	(	-LRB-
cord-263157-8jin6oru	134	2	Table	Table	NNP
cord-263157-8jin6oru	134	3	 	 	_SP
cord-263157-8jin6oru	134	4	17	17	CD
cord-263157-8jin6oru	134	5	.2	.2	CD
cord-263157-8jin6oru	134	6	)	)	-RRB-
cord-263157-8jin6oru	135	1	(	(	-LRB-
cord-263157-8jin6oru	135	2	53	53	CD
cord-263157-8jin6oru	135	3	)	)	-RRB-
cord-263157-8jin6oru	135	4	.	.	.
cord-263157-8jin6oru	136	1	If	if	IN
cord-263157-8jin6oru	136	2	one	one	PRP
cord-263157-8jin6oru	136	3	assumes	assume	VBZ
cord-263157-8jin6oru	136	4	that	that	IN
cord-263157-8jin6oru	136	5	10	10	CD
cord-263157-8jin6oru	136	6	9	9	CD
cord-263157-8jin6oru	136	7	-10	-10	CD
cord-263157-8jin6oru	136	8	10	10	CD
cord-263157-8jin6oru	136	9	viral	viral	JJ
cord-263157-8jin6oru	136	10	particles	particle	NNS
cord-263157-8jin6oru	136	11	are	be	VBP
cord-263157-8jin6oru	136	12	produced	produce	VBN
cord-263157-8jin6oru	136	13	each	each	DT
cord-263157-8jin6oru	136	14	day	day	NN
cord-263157-8jin6oru	136	15	in	in	IN
cord-263157-8jin6oru	136	16	an	an	DT
cord-263157-8jin6oru	136	17	infected	infected	JJ
cord-263157-8jin6oru	136	18	person	person	NN
cord-263157-8jin6oru	136	19	(	(	-LRB-
cord-263157-8jin6oru	136	20	54	54	CD
cord-263157-8jin6oru	136	21	,	,	,
cord-263157-8jin6oru	136	22	55	55	CD
cord-263157-8jin6oru	136	23	)	)	-RRB-
cord-263157-8jin6oru	136	24	,	,	,
cord-263157-8jin6oru	136	25	these	these	DT
cord-263157-8jin6oru	136	26	must	must	MD
cord-263157-8jin6oru	136	27	be	be	VB
cord-263157-8jin6oru	136	28	the	the	DT
cord-263157-8jin6oru	136	29	product	product	NN
cord-263157-8jin6oru	136	30	of	of	IN
cord-263157-8jin6oru	136	31	at	at	RB
cord-263157-8jin6oru	136	32	least	least	RBS
cord-263157-8jin6oru	136	33	10	10	CD
cord-263157-8jin6oru	136	34	7	7	CD
cord-263157-8jin6oru	136	35	-10	-10	SYM
cord-263157-8jin6oru	136	36	8	8	CD
cord-263157-8jin6oru	136	37	replication	replication	NN
cord-263157-8jin6oru	136	38	cycles	cycle	NNS
cord-263157-8jin6oru	136	39	.	.	.
cord-263157-8jin6oru	137	1	Given	give	VBN
cord-263157-8jin6oru	137	2	the	the	DT
cord-263157-8jin6oru	137	3	length	length	NN
cord-263157-8jin6oru	137	4	of	of	IN
cord-263157-8jin6oru	137	5	the	the	DT
cord-263157-8jin6oru	137	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	137	7	genome	genome	NN
cord-263157-8jin6oru	137	8	(	(	-LRB-
cord-263157-8jin6oru	137	9	approximately	approximately	RB
cord-263157-8jin6oru	137	10	10,000	10,000	CD
cord-263157-8jin6oru	137	11	nucleotides	nucleotide	NNS
cord-263157-8jin6oru	137	12	)	)	-RRB-
cord-263157-8jin6oru	137	13	and	and	CC
cord-263157-8jin6oru	137	14	its	-PRON-	PRP$
cord-263157-8jin6oru	137	15	high	high	JJ
cord-263157-8jin6oru	137	16	recombination	recombination	NN
cord-263157-8jin6oru	137	17	rate	rate	NN
cord-263157-8jin6oru	137	18	(	(	-LRB-
cord-263157-8jin6oru	137	19	56	56	CD
cord-263157-8jin6oru	137	20	)	)	-RRB-
cord-263157-8jin6oru	137	21	,	,	,
cord-263157-8jin6oru	137	22	it	-PRON-	PRP
cord-263157-8jin6oru	137	23	is	be	VBZ
cord-263157-8jin6oru	137	24	likely	likely	JJ
cord-263157-8jin6oru	137	25	that	that	IN
cord-263157-8jin6oru	137	26	every	every	DT
cord-263157-8jin6oru	137	27	single	single	JJ
cord-263157-8jin6oru	137	28	possible	possible	JJ
cord-263157-8jin6oru	137	29	point	point	NN
cord-263157-8jin6oru	137	30	mutation	mutation	NN
cord-263157-8jin6oru	137	31	(	(	-LRB-
cord-263157-8jin6oru	137	32	and	and	CC
cord-263157-8jin6oru	137	33	likely	likely	RB
cord-263157-8jin6oru	137	34	many	many	JJ
cord-263157-8jin6oru	137	35	double	double	JJ
cord-263157-8jin6oru	137	36	mutations	mutation	NNS
cord-263157-8jin6oru	137	37	)	)	-RRB-
cord-263157-8jin6oru	137	38	will	will	MD
cord-263157-8jin6oru	137	39	occur	occur	VB
cord-263157-8jin6oru	137	40	at	at	IN
cord-263157-8jin6oru	137	41	least	least	JJS
cord-263157-8jin6oru	137	42	once	once	RB
cord-263157-8jin6oru	137	43	each	each	DT
cord-263157-8jin6oru	137	44	day	day	NN
cord-263157-8jin6oru	137	45	in	in	IN
cord-263157-8jin6oru	137	46	an	an	DT
cord-263157-8jin6oru	137	47	infected	infected	JJ
cord-263157-8jin6oru	137	48	individual	individual	NN
cord-263157-8jin6oru	137	49	(	(	-LRB-
cord-263157-8jin6oru	137	50	57	57	CD
cord-263157-8jin6oru	137	51	,	,	,
cord-263157-8jin6oru	137	52	58	58	CD
cord-263157-8jin6oru	137	53	)	)	-RRB-
cord-263157-8jin6oru	137	54	.	.	.
cord-263157-8jin6oru	138	1	Although	although	IN
cord-263157-8jin6oru	138	2	specific	specific	JJ
cord-263157-8jin6oru	138	3	combinations	combination	NNS
cord-263157-8jin6oru	138	4	of	of	IN
cord-263157-8jin6oru	138	5	multiple	multiple	JJ
cord-263157-8jin6oru	138	6	mutations	mutation	NNS
cord-263157-8jin6oru	138	7	may	may	MD
cord-263157-8jin6oru	138	8	be	be	VB
cord-263157-8jin6oru	138	9	rare	rare	JJ
cord-263157-8jin6oru	138	10	,	,	,
cord-263157-8jin6oru	138	11	it	-PRON-	PRP
cord-263157-8jin6oru	138	12	is	be	VBZ
cord-263157-8jin6oru	138	13	clear	clear	JJ
cord-263157-8jin6oru	138	14	that	that	IN
cord-263157-8jin6oru	138	15	the	the	DT
cord-263157-8jin6oru	138	16	degree	degree	NN
cord-263157-8jin6oru	138	17	of	of	IN
cord-263157-8jin6oru	138	18	potential	potential	JJ
cord-263157-8jin6oru	138	19	genetic	genetic	JJ
cord-263157-8jin6oru	138	20	change	change	NN
cord-263157-8jin6oru	138	21	drives	drive	VBZ
cord-263157-8jin6oru	138	22	the	the	DT
cord-263157-8jin6oru	138	23	diversification	diversification	NN
cord-263157-8jin6oru	138	24	of	of	IN
cord-263157-8jin6oru	138	25	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	138	26	in	in	IN
cord-263157-8jin6oru	138	27	response	response	NN
cord-263157-8jin6oru	138	28	to	to	IN
cord-263157-8jin6oru	138	29	the	the	DT
cord-263157-8jin6oru	138	30	selective	selective	JJ
cord-263157-8jin6oru	138	31	pressure	pressure	NN
cord-263157-8jin6oru	138	32	of	of	IN
cord-263157-8jin6oru	138	33	host	host	NN
cord-263157-8jin6oru	138	34	immune	immune	JJ
cord-263157-8jin6oru	138	35	responses	response	NNS
cord-263157-8jin6oru	138	36	or	or	CC
cord-263157-8jin6oru	138	37	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	138	38	therapy	therapy	NN
cord-263157-8jin6oru	138	39	(	(	-LRB-
cord-263157-8jin6oru	138	40	Table	Table	NNP
cord-263157-8jin6oru	138	41	17	17	CD
cord-263157-8jin6oru	138	42	.2	.2	CD
cord-263157-8jin6oru	138	43	)	)	-RRB-
cord-263157-8jin6oru	138	44	.	.	.
cord-263157-8jin6oru	139	1	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	139	2	strains	strain	NNS
cord-263157-8jin6oru	139	3	have	have	VBP
cord-263157-8jin6oru	139	4	diversified	diversify	VBN
cord-263157-8jin6oru	139	5	extensively	extensively	RB
cord-263157-8jin6oru	139	6	through	through	IN
cord-263157-8jin6oru	139	7	mutation	mutation	NN
cord-263157-8jin6oru	139	8	and	and	CC
cord-263157-8jin6oru	139	9	recombination	recombination	NN
cord-263157-8jin6oru	139	10	since	since	IN
cord-263157-8jin6oru	139	11	their	-PRON-	PRP$
cord-263157-8jin6oru	139	12	initial	initial	JJ
cord-263157-8jin6oru	139	13	transmission	transmission	NN
cord-263157-8jin6oru	139	14	to	to	IN
cord-263157-8jin6oru	139	15	humans	human	NNS
cord-263157-8jin6oru	139	16	many	many	JJ
cord-263157-8jin6oru	139	17	decades	decade	NNS
cord-263157-8jin6oru	139	18	ago	ago	RB
cord-263157-8jin6oru	139	19	in	in	IN
cord-263157-8jin6oru	139	20	central	central	JJ
cord-263157-8jin6oru	139	21	Africa	Africa	NNP
cord-263157-8jin6oru	139	22	.	.	.
cord-263157-8jin6oru	140	1	Phylogenetic	phylogenetic	JJ
cord-263157-8jin6oru	140	2	analysis	analysis	NN
cord-263157-8jin6oru	140	3	of	of	IN
cord-263157-8jin6oru	140	4	numerous	numerous	JJ
cord-263157-8jin6oru	140	5	isolates	isolate	NNS
cord-263157-8jin6oru	140	6	obtained	obtain	VBN
cord-263157-8jin6oru	140	7	from	from	IN
cord-263157-8jin6oru	140	8	diverse	diverse	JJ
cord-263157-8jin6oru	140	9	geographic	geographic	JJ
cord-263157-8jin6oru	140	10	origins	origin	NNS
cord-263157-8jin6oru	140	11	has	have	VBZ
cord-263157-8jin6oru	140	12	allowed	allow	VBN
cord-263157-8jin6oru	140	13	the	the	DT
cord-263157-8jin6oru	140	14	division	division	NN
cord-263157-8jin6oru	140	15	of	of	IN
cord-263157-8jin6oru	140	16	HIV	HIV	NNP
cord-263157-8jin6oru	140	17	into	into	IN
cord-263157-8jin6oru	140	18	types	type	NNS
cord-263157-8jin6oru	140	19	,	,	,
cord-263157-8jin6oru	140	20	groups	group	NNS
cord-263157-8jin6oru	140	21	,	,	,
cord-263157-8jin6oru	140	22	subtypes	subtype	NNS
cord-263157-8jin6oru	140	23	,	,	,
cord-263157-8jin6oru	140	24	sub	sub	NN
cord-263157-8jin6oru	140	25	-	-	NNS
cord-263157-8jin6oru	140	26	subtypes	subtype	NNS
cord-263157-8jin6oru	140	27	,	,	,
cord-263157-8jin6oru	140	28	circulating	circulate	VBG
cord-263157-8jin6oru	140	29	recombinant	recombinant	JJ
cord-263157-8jin6oru	140	30	forms	form	NNS
cord-263157-8jin6oru	140	31	(	(	-LRB-
cord-263157-8jin6oru	140	32	CRFs	CRFs	NNP
cord-263157-8jin6oru	140	33	)	)	-RRB-
cord-263157-8jin6oru	140	34	and	and	CC
cord-263157-8jin6oru	140	35	unique	unique	JJ
cord-263157-8jin6oru	140	36	recombinant	recombinant	JJ
cord-263157-8jin6oru	140	37	forms	form	NNS
cord-263157-8jin6oru	140	38	(	(	-LRB-
cord-263157-8jin6oru	140	39	URFs	URFs	NNP
cord-263157-8jin6oru	140	40	)	)	-RRB-
cord-263157-8jin6oru	140	41	.	.	.
cord-263157-8jin6oru	141	1	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	141	2	is	be	VBZ
cord-263157-8jin6oru	141	3	divided	divide	VBN
cord-263157-8jin6oru	141	4	into	into	IN
cord-263157-8jin6oru	141	5	three	three	CD
cord-263157-8jin6oru	141	6	groups	group	NNS
cord-263157-8jin6oru	141	7	,	,	,
cord-263157-8jin6oru	141	8	M	M	NNP
cord-263157-8jin6oru	141	9	,	,	,
cord-263157-8jin6oru	141	10	O	o	UH
cord-263157-8jin6oru	141	11	and	and	CC
cord-263157-8jin6oru	141	12	N	N	NNP
cord-263157-8jin6oru	141	13	(	(	-LRB-
cord-263157-8jin6oru	141	14	59	59	CD
cord-263157-8jin6oru	141	15	)	)	-RRB-
cord-263157-8jin6oru	141	16	.	.	.
cord-263157-8jin6oru	142	1	Most	Most	JJS
cord-263157-8jin6oru	142	2	sequences	sequence	NNS
cord-263157-8jin6oru	142	3	within	within	IN
cord-263157-8jin6oru	142	4	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	142	5	group	group	NN
cord-263157-8jin6oru	142	6	M	M	NNP
cord-263157-8jin6oru	142	7	,	,	,
cord-263157-8jin6oru	142	8	which	which	WDT
cord-263157-8jin6oru	142	9	accounts	account	VBZ
cord-263157-8jin6oru	142	10	for	for	IN
cord-263157-8jin6oru	142	11	the	the	DT
cord-263157-8jin6oru	142	12	majority	majority	NN
cord-263157-8jin6oru	142	13	of	of	IN
cord-263157-8jin6oru	142	14	infections	infection	NNS
cord-263157-8jin6oru	142	15	worldwide	worldwide	RB
cord-263157-8jin6oru	142	16	,	,	,
cord-263157-8jin6oru	142	17	fall	fall	VB
cord-263157-8jin6oru	142	18	into	into	IN
cord-263157-8jin6oru	142	19	a	a	DT
cord-263157-8jin6oru	142	20	limited	limited	JJ
cord-263157-8jin6oru	142	21	number	number	NN
cord-263157-8jin6oru	142	22	of	of	IN
cord-263157-8jin6oru	142	23	discrete	discrete	JJ
cord-263157-8jin6oru	142	24	clades	clade	NNS
cord-263157-8jin6oru	142	25	,	,	,
cord-263157-8jin6oru	142	26	allowing	allow	VBG
cord-263157-8jin6oru	142	27	the	the	DT
cord-263157-8jin6oru	142	28	classification	classification	NN
cord-263157-8jin6oru	142	29	into	into	IN
cord-263157-8jin6oru	142	30	subtypes	subtype	NNS
cord-263157-8jin6oru	142	31	and	and	CC
cord-263157-8jin6oru	142	32	sub	sub	NN
cord-263157-8jin6oru	142	33	-	-	NNS
cord-263157-8jin6oru	142	34	subtypes	subtype	NNS
cord-263157-8jin6oru	142	35	.	.	.
cord-263157-8jin6oru	143	1	Near	near	IN
cord-263157-8jin6oru	143	2	30	30	CD
cord-263157-8jin6oru	143	3	circulating	circulate	VBG
cord-263157-8jin6oru	143	4	genetic	genetic	JJ
cord-263157-8jin6oru	143	5	forms	form	NNS
cord-263157-8jin6oru	143	6	of	of	IN
cord-263157-8jin6oru	143	7	the	the	DT
cord-263157-8jin6oru	143	8	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	143	9	group	group	NN
cord-263157-8jin6oru	143	10	M	M	NNP
cord-263157-8jin6oru	143	11	are	be	VBP
cord-263157-8jin6oru	143	12	presently	presently	RB
cord-263157-8jin6oru	143	13	recognized	recognize	VBN
cord-263157-8jin6oru	143	14	,	,	,
cord-263157-8jin6oru	143	15	including	include	VBG
cord-263157-8jin6oru	143	16	11	11	CD
cord-263157-8jin6oru	143	17	subtypes	subtype	NNS
cord-263157-8jin6oru	143	18	and	and	CC
cord-263157-8jin6oru	143	19	sub	sub	NN
cord-263157-8jin6oru	143	20	-	-	NNS
cord-263157-8jin6oru	143	21	subtypes	subtype	NNS
cord-263157-8jin6oru	143	22	,	,	,
cord-263157-8jin6oru	143	23	and	and	CC
cord-263157-8jin6oru	143	24	nearly	nearly	RB
cord-263157-8jin6oru	143	25	20	20	CD
cord-263157-8jin6oru	143	26	CRF	crf	NN
cord-263157-8jin6oru	143	27	.	.	.
cord-263157-8jin6oru	144	1	The	the	DT
cord-263157-8jin6oru	144	2	diverse	diverse	JJ
cord-263157-8jin6oru	144	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	144	4	subtypes	subtype	NNS
cord-263157-8jin6oru	144	5	,	,	,
cord-263157-8jin6oru	144	6	CRFs	CRFs	NNP
cord-263157-8jin6oru	144	7	and	and	CC
cord-263157-8jin6oru	144	8	the	the	DT
cord-263157-8jin6oru	144	9	inter	inter	JJ
cord-263157-8jin6oru	144	10	-	-	JJ
cord-263157-8jin6oru	144	11	subtype	subtype	JJ
cord-263157-8jin6oru	144	12	mosaic	mosaic	NN
cord-263157-8jin6oru	144	13	genomes	genome	NNS
cord-263157-8jin6oru	144	14	further	further	RB
cord-263157-8jin6oru	144	15	exacerbate	exacerbate	VBP
cord-263157-8jin6oru	144	16	the	the	DT
cord-263157-8jin6oru	144	17	problem	problem	NN
cord-263157-8jin6oru	144	18	of	of	IN
cord-263157-8jin6oru	144	19	designing	design	VBG
cord-263157-8jin6oru	144	20	effective	effective	JJ
cord-263157-8jin6oru	144	21	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	144	22	.	.	.
cord-263157-8jin6oru	145	1	Boden	Boden	NNP
cord-263157-8jin6oru	145	2	et	et	NNP
cord-263157-8jin6oru	145	3	al	al	NNP
cord-263157-8jin6oru	145	4	.	.	.
cord-263157-8jin6oru	146	1	(	(	-LRB-
cord-263157-8jin6oru	146	2	51	51	CD
cord-263157-8jin6oru	146	3	)	)	-RRB-
cord-263157-8jin6oru	146	4	characterized	characterize	VBD
cord-263157-8jin6oru	146	5	the	the	DT
cord-263157-8jin6oru	146	6	potency	potency	NN
cord-263157-8jin6oru	146	7	and	and	CC
cord-263157-8jin6oru	146	8	durability	durability	NN
cord-263157-8jin6oru	146	9	of	of	IN
cord-263157-8jin6oru	146	10	virus	virus	NN
cord-263157-8jin6oru	146	11	-	-	HYPH
cord-263157-8jin6oru	146	12	specific	specific	JJ
cord-263157-8jin6oru	146	13	RNAi	RNAi	NNS
cord-263157-8jin6oru	146	14	in	in	IN
cord-263157-8jin6oru	146	15	cell	cell	NN
cord-263157-8jin6oru	146	16	lines	line	NNS
cord-263157-8jin6oru	146	17	that	that	WDT
cord-263157-8jin6oru	146	18	stably	stably	RB
cord-263157-8jin6oru	146	19	expressed	express	VBD
cord-263157-8jin6oru	146	20	shRNA	shrna	NN
cord-263157-8jin6oru	146	21	targeting	target	VBG
cord-263157-8jin6oru	146	22	the	the	DT
cord-263157-8jin6oru	146	23	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	146	24	transactivator	transactivator	NN
cord-263157-8jin6oru	146	25	protein	protein	NN
cord-263157-8jin6oru	146	26	gene	gene	NN
cord-263157-8jin6oru	146	27	Tat	Tat	NNP
cord-263157-8jin6oru	146	28	.	.	.
cord-263157-8jin6oru	147	1	They	-PRON-	PRP
cord-263157-8jin6oru	147	2	found	find	VBD
cord-263157-8jin6oru	147	3	that	that	IN
cord-263157-8jin6oru	147	4	the	the	DT
cord-263157-8jin6oru	147	5	antiviral	antiviral	JJ
cord-263157-8jin6oru	147	6	activity	activity	NN
cord-263157-8jin6oru	147	7	of	of	IN
cord-263157-8jin6oru	147	8	Tat	Tat	NNP
cord-263157-8jin6oru	147	9	shRNA	shrna	NN
cord-263157-8jin6oru	147	10	was	be	VBD
cord-263157-8jin6oru	147	11	abolished	abolish	VBN
cord-263157-8jin6oru	147	12	due	due	IN
cord-263157-8jin6oru	147	13	to	to	IN
cord-263157-8jin6oru	147	14	the	the	DT
cord-263157-8jin6oru	147	15	emergence	emergence	NN
cord-263157-8jin6oru	147	16	of	of	IN
cord-263157-8jin6oru	147	17	viral	viral	JJ
cord-263157-8jin6oru	147	18	species	specie	NNS
cord-263157-8jin6oru	147	19	harboring	harbor	VBG
cord-263157-8jin6oru	147	20	a	a	DT
cord-263157-8jin6oru	147	21	point	point	NN
cord-263157-8jin6oru	147	22	mutation	mutation	NN
cord-263157-8jin6oru	147	23	in	in	IN
cord-263157-8jin6oru	147	24	the	the	DT
cord-263157-8jin6oru	147	25	shRNA	shrna	NN
cord-263157-8jin6oru	147	26	target	target	NN
cord-263157-8jin6oru	147	27	region	region	NN
cord-263157-8jin6oru	147	28	.	.	.
cord-263157-8jin6oru	148	1	During	during	IN
cord-263157-8jin6oru	148	2	the	the	DT
cord-263157-8jin6oru	148	3	first	first	JJ
cord-263157-8jin6oru	148	4	three	three	CD
cord-263157-8jin6oru	148	5	weeks	week	NNS
cord-263157-8jin6oru	148	6	,	,	,
cord-263157-8jin6oru	148	7	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	148	8	replication	replication	NN
cord-263157-8jin6oru	148	9	was	be	VBD
cord-263157-8jin6oru	148	10	reduced	reduce	VBN
cord-263157-8jin6oru	148	11	by	by	IN
cord-263157-8jin6oru	148	12	95	95	CD
cord-263157-8jin6oru	148	13	%	%	NN
cord-263157-8jin6oru	148	14	in	in	IN
cord-263157-8jin6oru	148	15	cells	cell	NNS
cord-263157-8jin6oru	148	16	expressing	express	VBG
cord-263157-8jin6oru	148	17	Tat	Tat	NNP
cord-263157-8jin6oru	148	18	shRNA	shrna	NN
cord-263157-8jin6oru	148	19	compared	compare	VBN
cord-263157-8jin6oru	148	20	to	to	TO
cord-263157-8jin6oru	148	21	control	control	NN
cord-263157-8jin6oru	148	22	cells	cell	NNS
cord-263157-8jin6oru	148	23	.	.	.
cord-263157-8jin6oru	149	1	By	by	IN
cord-263157-8jin6oru	149	2	day	day	NN
cord-263157-8jin6oru	149	3	25	25	CD
cord-263157-8jin6oru	149	4	,	,	,
cord-263157-8jin6oru	149	5	however	however	RB
cord-263157-8jin6oru	149	6	,	,	,
cord-263157-8jin6oru	149	7	viral	viral	JJ
cord-263157-8jin6oru	149	8	titers	titer	NNS
cord-263157-8jin6oru	149	9	increased	increase	VBD
cord-263157-8jin6oru	149	10	,	,	,
cord-263157-8jin6oru	149	11	indicating	indicate	VBG
cord-263157-8jin6oru	149	12	loss	loss	NN
cord-263157-8jin6oru	149	13	of	of	IN
cord-263157-8jin6oru	149	14	Tat	Tat	NNP
cord-263157-8jin6oru	149	15	shRNA	shrna	NN
cord-263157-8jin6oru	149	16	-	-	HYPH
cord-263157-8jin6oru	149	17	mediated	mediate	VBN
cord-263157-8jin6oru	149	18	antiviral	antiviral	JJ
cord-263157-8jin6oru	149	19	activity	activity	NN
cord-263157-8jin6oru	149	20	,	,	,
cord-263157-8jin6oru	149	21	and	and	CC
cord-263157-8jin6oru	149	22	sequencing	sequencing	NN
cord-263157-8jin6oru	149	23	of	of	IN
cord-263157-8jin6oru	149	24	this	this	DT
cord-263157-8jin6oru	149	25	virus	virus	NN
cord-263157-8jin6oru	149	26	stock	stock	NN
cord-263157-8jin6oru	149	27	revealed	reveal	VBD
cord-263157-8jin6oru	149	28	that	that	IN
cord-263157-8jin6oru	149	29	the	the	DT
cord-263157-8jin6oru	149	30	emerged	emerge	VBN
cord-263157-8jin6oru	149	31	viral	viral	JJ
cord-263157-8jin6oru	149	32	species	specie	NNS
cord-263157-8jin6oru	149	33	contained	contain	VBD
cord-263157-8jin6oru	149	34	a	a	DT
cord-263157-8jin6oru	149	35	nonsynonymous	nonsynonymous	JJ
cord-263157-8jin6oru	149	36	mutation	mutation	NN
cord-263157-8jin6oru	149	37	at	at	IN
cord-263157-8jin6oru	149	38	nucleotide	nucleotide	JJ
cord-263157-8jin6oru	149	39	position	position	NN
cord-263157-8jin6oru	149	40	9	9	CD
cord-263157-8jin6oru	149	41	of	of	IN
cord-263157-8jin6oru	149	42	the	the	DT
cord-263157-8jin6oru	149	43	targeted	target	VBN
cord-263157-8jin6oru	149	44	sequence	sequence	NN
cord-263157-8jin6oru	149	45	.	.	.
cord-263157-8jin6oru	150	1	Das	Das	NNP
cord-263157-8jin6oru	150	2	et	et	FW
cord-263157-8jin6oru	150	3	al	al	NNP
cord-263157-8jin6oru	150	4	.	.	.
cord-263157-8jin6oru	151	1	(	(	-LRB-
cord-263157-8jin6oru	151	2	36	36	CD
cord-263157-8jin6oru	151	3	)	)	-RRB-
cord-263157-8jin6oru	151	4	used	use	VBN
cord-263157-8jin6oru	151	5	retroviral	retroviral	NN
cord-263157-8jin6oru	151	6	transduction	transduction	NN
cord-263157-8jin6oru	151	7	to	to	TO
cord-263157-8jin6oru	151	8	stably	stably	RB
cord-263157-8jin6oru	151	9	introduce	introduce	VB
cord-263157-8jin6oru	151	10	vectors	vector	NNS
cord-263157-8jin6oru	151	11	expressing	express	VBG
cord-263157-8jin6oru	151	12	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	151	13	directed	direct	VBN
cord-263157-8jin6oru	151	14	against	against	IN
cord-263157-8jin6oru	151	15	 	 	_SP
cord-263157-8jin6oru	151	16	Generally	generally	RB
cord-263157-8jin6oru	151	17	this	this	DT
cord-263157-8jin6oru	151	18	averages	average	VBZ
cord-263157-8jin6oru	151	19	at	at	IN
cord-263157-8jin6oru	151	20	1	1	CD
cord-263157-8jin6oru	151	21	-	-	SYM
cord-263157-8jin6oru	151	22	100	100	CD
cord-263157-8jin6oru	151	23	(	(	-LRB-
cord-263157-8jin6oru	151	24	if	if	IN
cord-263157-8jin6oru	151	25	not	not	RB
cord-263157-8jin6oru	151	26	longer	long	JJR
cord-263157-8jin6oru	151	27	in	in	IN
cord-263157-8jin6oru	151	28	some	some	DT
cord-263157-8jin6oru	151	29	cases	case	NNS
cord-263157-8jin6oru	151	30	)	)	-RRB-
cord-263157-8jin6oru	151	31	mutations	mutation	NNS
cord-263157-8jin6oru	151	32	per	per	IN
cord-263157-8jin6oru	151	33	genome	genome	NN
cord-263157-8jin6oru	151	34	.	.	.
cord-263157-8jin6oru	152	1	Error	error	NN
cord-263157-8jin6oru	152	2	rate	rate	NN
cord-263157-8jin6oru	152	3	has	have	VBZ
cord-263157-8jin6oru	152	4	been	be	VBN
cord-263157-8jin6oru	152	5	estimated	estimate	VBN
cord-263157-8jin6oru	152	6	at	at	IN
cord-263157-8jin6oru	152	7	between	between	IN
cord-263157-8jin6oru	152	8	10	10	CD
cord-263157-8jin6oru	152	9	−4	−4	CD
cord-263157-8jin6oru	153	1	to	to	IN
cord-263157-8jin6oru	153	2	10	10	CD
cord-263157-8jin6oru	153	3	−5	−5	NNS
cord-263157-8jin6oru	153	4	mutations	mutation	NNS
cord-263157-8jin6oru	153	5	per	per	IN
cord-263157-8jin6oru	153	6	nucleotide	nucleotide	NN
cord-263157-8jin6oru	153	7	and	and	CC
cord-263157-8jin6oru	153	8	cycle	cycle	NN
cord-263157-8jin6oru	153	9	of	of	IN
cord-263157-8jin6oru	153	10	replication	replication	NN
cord-263157-8jin6oru	153	11	.	.	.
cord-263157-8jin6oru	154	1	10	10	CD
cord-263157-8jin6oru	154	2	kb	kb	NNP
cord-263157-8jin6oru	154	3	Variable	Variable	NNP
cord-263157-8jin6oru	154	4	but	but	CC
cord-263157-8jin6oru	154	5	10	10	CD
cord-263157-8jin6oru	154	6	9	9	CD
cord-263157-8jin6oru	154	7	-10	-10	CD
cord-263157-8jin6oru	154	8	10	10	CD
cord-263157-8jin6oru	154	9	viral	viral	JJ
cord-263157-8jin6oru	154	10	particles	particle	NNS
cord-263157-8jin6oru	154	11	can	can	MD
cord-263157-8jin6oru	154	12	be	be	VB
cord-263157-8jin6oru	154	13	produced	produce	VBN
cord-263157-8jin6oru	154	14	each	each	DT
cord-263157-8jin6oru	154	15	day	day	NN
cord-263157-8jin6oru	154	16	in	in	IN
cord-263157-8jin6oru	154	17	an	an	DT
cord-263157-8jin6oru	154	18	infected	infected	JJ
cord-263157-8jin6oru	154	19	individual	individual	NN
cord-263157-8jin6oru	154	20	.	.	.
cord-263157-8jin6oru	155	1	Every	every	DT
cord-263157-8jin6oru	155	2	single	single	JJ
cord-263157-8jin6oru	155	3	possible	possible	JJ
cord-263157-8jin6oru	155	4	point	point	NN
cord-263157-8jin6oru	155	5	mutation	mutation	NN
cord-263157-8jin6oru	155	6	(	(	-LRB-
cord-263157-8jin6oru	155	7	and	and	CC
cord-263157-8jin6oru	155	8	probably	probably	RB
cord-263157-8jin6oru	155	9	many	many	JJ
cord-263157-8jin6oru	155	10	double	double	JJ
cord-263157-8jin6oru	155	11	mutations	mutation	NNS
cord-263157-8jin6oru	155	12	)	)	-RRB-
cord-263157-8jin6oru	155	13	will	will	MD
cord-263157-8jin6oru	155	14	occur	occur	VB
cord-263157-8jin6oru	155	15	at	at	IN
cord-263157-8jin6oru	155	16	least	least	JJS
cord-263157-8jin6oru	155	17	once	once	RB
cord-263157-8jin6oru	155	18	each	each	DT
cord-263157-8jin6oru	155	19	day	day	NN
cord-263157-8jin6oru	155	20	in	in	IN
cord-263157-8jin6oru	155	21	an	an	DT
cord-263157-8jin6oru	155	22	infected	infected	JJ
cord-263157-8jin6oru	155	23	individual	individual	NN
cord-263157-8jin6oru	155	24	.	.	.
cord-263157-8jin6oru	156	1	Many	many	JJ
cord-263157-8jin6oru	156	2	recorded	record	VBN
cord-263157-8jin6oru	156	3	adaptive	adaptive	JJ
cord-263157-8jin6oru	156	4	changes	change	NNS
cord-263157-8jin6oru	156	5	depend	depend	VBP
cord-263157-8jin6oru	156	6	on	on	IN
cord-263157-8jin6oru	156	7	one	one	CD
cord-263157-8jin6oru	156	8	or	or	CC
cord-263157-8jin6oru	156	9	a	a	DT
cord-263157-8jin6oru	156	10	few	few	JJ
cord-263157-8jin6oru	156	11	mutations	mutation	NNS
cord-263157-8jin6oru	156	12	.	.	.
cord-263157-8jin6oru	157	1	Based	base	VBN
cord-263157-8jin6oru	157	2	on	on	IN
cord-263157-8jin6oru	157	3	(	(	-LRB-
cord-263157-8jin6oru	157	4	57	57	CD
cord-263157-8jin6oru	157	5	,	,	,
cord-263157-8jin6oru	157	6	58	58	CD
cord-263157-8jin6oru	157	7	)	)	-RRB-
cord-263157-8jin6oru	157	8	the	the	DT
cord-263157-8jin6oru	157	9	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	157	10	Nef	Nef	NNP
cord-263157-8jin6oru	157	11	gene	gene	NN
cord-263157-8jin6oru	157	12	into	into	IN
cord-263157-8jin6oru	157	13	human	human	JJ
cord-263157-8jin6oru	157	14	T	t	NN
cord-263157-8jin6oru	157	15	cells	cell	NNS
cord-263157-8jin6oru	157	16	;	;	:
cord-263157-8jin6oru	157	17	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	157	18	escape	escape	NN
cord-263157-8jin6oru	157	19	variants	variant	NNS
cord-263157-8jin6oru	157	20	that	that	WDT
cord-263157-8jin6oru	157	21	were	be	VBD
cord-263157-8jin6oru	157	22	resistant	resistant	JJ
cord-263157-8jin6oru	157	23	to	to	IN
cord-263157-8jin6oru	157	24	siRNA	siRNA	NNP
cord-263157-8jin6oru	157	25	-	-	HYPH
cord-263157-8jin6oru	157	26	Nef	Nef	NNP
cord-263157-8jin6oru	157	27	appeared	appear	VBD
cord-263157-8jin6oru	157	28	after	after	IN
cord-263157-8jin6oru	157	29	several	several	JJ
cord-263157-8jin6oru	157	30	weeks	week	NNS
cord-263157-8jin6oru	157	31	of	of	IN
cord-263157-8jin6oru	157	32	culture	culture	NN
cord-263157-8jin6oru	157	33	,	,	,
cord-263157-8jin6oru	157	34	and	and	CC
cord-263157-8jin6oru	157	35	these	these	DT
cord-263157-8jin6oru	157	36	RNAi	RNAi	NNS
cord-263157-8jin6oru	157	37	-	-	HYPH
cord-263157-8jin6oru	157	38	resistant	resistant	JJ
cord-263157-8jin6oru	157	39	viruses	virus	NNS
cord-263157-8jin6oru	157	40	contained	contain	VBN
cord-263157-8jin6oru	157	41	point	point	NN
cord-263157-8jin6oru	157	42	mutations	mutation	NNS
cord-263157-8jin6oru	157	43	,	,	,
cord-263157-8jin6oru	157	44	double	double	JJ
cord-263157-8jin6oru	157	45	point	point	NN
cord-263157-8jin6oru	157	46	mutations	mutation	NNS
cord-263157-8jin6oru	157	47	or	or	CC
cord-263157-8jin6oru	157	48	partial	partial	JJ
cord-263157-8jin6oru	157	49	or	or	CC
cord-263157-8jin6oru	157	50	complete	complete	JJ
cord-263157-8jin6oru	157	51	deletion	deletion	NN
cord-263157-8jin6oru	157	52	of	of	IN
cord-263157-8jin6oru	157	53	the	the	DT
cord-263157-8jin6oru	157	54	Nef	Nef	NNP
cord-263157-8jin6oru	157	55	gene	gene	NN
cord-263157-8jin6oru	157	56	target	target	NN
cord-263157-8jin6oru	157	57	sequence	sequence	NN
cord-263157-8jin6oru	157	58	.	.	.
cord-263157-8jin6oru	158	1	The	the	DT
cord-263157-8jin6oru	158	2	complete	complete	JJ
cord-263157-8jin6oru	158	3	inactivation	inactivation	NN
cord-263157-8jin6oru	158	4	of	of	IN
cord-263157-8jin6oru	158	5	the	the	DT
cord-263157-8jin6oru	158	6	accessory	accessory	NN
cord-263157-8jin6oru	158	7	Nef	Nef	NNP
cord-263157-8jin6oru	158	8	gene	gene	NN
cord-263157-8jin6oru	158	9	has	have	VBZ
cord-263157-8jin6oru	158	10	a	a	DT
cord-263157-8jin6oru	158	11	relatively	relatively	RB
cord-263157-8jin6oru	158	12	minor	minor	JJ
cord-263157-8jin6oru	158	13	impact	impact	NN
cord-263157-8jin6oru	158	14	on	on	IN
cord-263157-8jin6oru	158	15	the	the	DT
cord-263157-8jin6oru	158	16	replication	replication	NN
cord-263157-8jin6oru	158	17	capacity	capacity	NN
cord-263157-8jin6oru	158	18	of	of	IN
cord-263157-8jin6oru	158	19	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	158	20	ex	ex	NN
cord-263157-8jin6oru	158	21	vivo	vivo	NN
cord-263157-8jin6oru	158	22	.	.	.
cord-263157-8jin6oru	159	1	Interestingly	interestingly	RB
cord-263157-8jin6oru	159	2	,	,	,
cord-263157-8jin6oru	159	3	Westerhout	Westerhout	NNP
cord-263157-8jin6oru	159	4	et	et	NNP
cord-263157-8jin6oru	159	5	al	al	NNP
cord-263157-8jin6oru	159	6	.	.	.
cord-263157-8jin6oru	160	1	(	(	-LRB-
cord-263157-8jin6oru	160	2	52	52	CD
cord-263157-8jin6oru	160	3	)	)	-RRB-
cord-263157-8jin6oru	160	4	used	use	VBN
cord-263157-8jin6oru	160	5	human	human	JJ
cord-263157-8jin6oru	160	6	T	t	NN
cord-263157-8jin6oru	160	7	cells	cell	NNS
cord-263157-8jin6oru	160	8	that	that	WDT
cord-263157-8jin6oru	160	9	stably	stably	RB
cord-263157-8jin6oru	160	10	express	express	VBP
cord-263157-8jin6oru	160	11	an	an	DT
cord-263157-8jin6oru	160	12	siRNA	siRNA	NNP
cord-263157-8jin6oru	160	13	-	-	HYPH
cord-263157-8jin6oru	160	14	Nef	Nef	NNP
cord-263157-8jin6oru	160	15	target	target	NN
cord-263157-8jin6oru	160	16	sequence	sequence	NN
cord-263157-8jin6oru	160	17	to	to	TO
cord-263157-8jin6oru	160	18	show	show	VB
cord-263157-8jin6oru	160	19	that	that	IN
cord-263157-8jin6oru	160	20	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	160	21	can	can	MD
cord-263157-8jin6oru	160	22	also	also	RB
cord-263157-8jin6oru	160	23	escape	escape	VB
cord-263157-8jin6oru	160	24	siRNA	siRNA	NNP
cord-263157-8jin6oru	160	25	-	-	HYPH
cord-263157-8jin6oru	160	26	mediated	mediate	VBN
cord-263157-8jin6oru	160	27	Nef	Nef	NNP
cord-263157-8jin6oru	160	28	inhibition	inhibition	NN
cord-263157-8jin6oru	160	29	by	by	IN
cord-263157-8jin6oru	160	30	a	a	DT
cord-263157-8jin6oru	160	31	point	point	NN
cord-263157-8jin6oru	160	32	mutation	mutation	NN
cord-263157-8jin6oru	160	33	outside	outside	IN
cord-263157-8jin6oru	160	34	the	the	DT
cord-263157-8jin6oru	160	35	target	target	NN
cord-263157-8jin6oru	160	36	sequence	sequence	NN
cord-263157-8jin6oru	160	37	.	.	.
cord-263157-8jin6oru	161	1	This	this	DT
cord-263157-8jin6oru	161	2	mutation	mutation	NN
cord-263157-8jin6oru	161	3	changed	change	VBD
cord-263157-8jin6oru	161	4	local	local	JJ
cord-263157-8jin6oru	161	5	RNA	RNA	NNP
cord-263157-8jin6oru	161	6	folding	folding	NN
cord-263157-8jin6oru	161	7	,	,	,
cord-263157-8jin6oru	161	8	such	such	JJ
cord-263157-8jin6oru	161	9	that	that	IN
cord-263157-8jin6oru	161	10	the	the	DT
cord-263157-8jin6oru	161	11	target	target	NN
cord-263157-8jin6oru	161	12	sequence	sequence	NN
cord-263157-8jin6oru	161	13	becomes	become	VBZ
cord-263157-8jin6oru	161	14	inaccessible	inaccessible	JJ
cord-263157-8jin6oru	161	15	to	to	IN
cord-263157-8jin6oru	161	16	the	the	DT
cord-263157-8jin6oru	161	17	RNAi	RNAi	NNP
cord-263157-8jin6oru	161	18	machinery	machinery	NN
cord-263157-8jin6oru	161	19	.	.	.
cord-263157-8jin6oru	162	1	Recently	recently	RB
cord-263157-8jin6oru	162	2	,	,	,
cord-263157-8jin6oru	162	3	Sabariegos	Sabariegos	NNP
cord-263157-8jin6oru	162	4	et	et	NNP
cord-263157-8jin6oru	162	5	al	al	NNP
cord-263157-8jin6oru	162	6	.	.	.
cord-263157-8jin6oru	163	1	(	(	-LRB-
cord-263157-8jin6oru	163	2	60	60	CD
cord-263157-8jin6oru	163	3	)	)	-RRB-
cord-263157-8jin6oru	163	4	showed	show	VBD
cord-263157-8jin6oru	163	5	that	that	IN
cord-263157-8jin6oru	163	6	optimal	optimal	JJ
cord-263157-8jin6oru	163	7	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	163	8	gene	gene	NN
cord-263157-8jin6oru	163	9	silencing	silence	VBG
cord-263157-8jin6oru	163	10	by	by	IN
cord-263157-8jin6oru	163	11	siRNA	siRNA	NNP
cord-263157-8jin6oru	163	12	requires	require	VBZ
cord-263157-8jin6oru	163	13	precise	precise	JJ
cord-263157-8jin6oru	163	14	complementarity	complementarity	NN
cord-263157-8jin6oru	163	15	with	with	IN
cord-263157-8jin6oru	163	16	most	most	JJS
cord-263157-8jin6oru	163	17	of	of	IN
cord-263157-8jin6oru	163	18	the	the	DT
cord-263157-8jin6oru	163	19	target	target	NN
cord-263157-8jin6oru	163	20	sequence	sequence	NN
cord-263157-8jin6oru	163	21	and	and	CC
cord-263157-8jin6oru	163	22	that	that	IN
cord-263157-8jin6oru	163	23	only	only	RB
cord-263157-8jin6oru	163	24	a	a	DT
cord-263157-8jin6oru	163	25	few	few	JJ
cord-263157-8jin6oru	163	26	substitutions	substitution	NNS
cord-263157-8jin6oru	163	27	at	at	IN
cord-263157-8jin6oru	163	28	the	the	DT
cord-263157-8jin6oru	163	29	5	5	CD
cord-263157-8jin6oru	163	30	′	′	CD
cord-263157-8jin6oru	163	31	and	and	CC
cord-263157-8jin6oru	163	32	3	3	CD
cord-263157-8jin6oru	163	33	′	′	CD
cord-263157-8jin6oru	163	34	ends	end	NNS
cord-263157-8jin6oru	163	35	are	be	VBP
cord-263157-8jin6oru	163	36	partially	partially	RB
cord-263157-8jin6oru	163	37	tolerated	tolerate	VBN
cord-263157-8jin6oru	163	38	.	.	.
cord-263157-8jin6oru	164	1	Viral	viral	JJ
cord-263157-8jin6oru	164	2	escape	escape	NN
cord-263157-8jin6oru	164	3	was	be	VBD
cord-263157-8jin6oru	164	4	simulated	simulate	VBN
cord-263157-8jin6oru	164	5	by	by	IN
cord-263157-8jin6oru	164	6	systematically	systematically	RB
cord-263157-8jin6oru	164	7	introducing	introduce	VBG
cord-263157-8jin6oru	164	8	single	single	JJ
cord-263157-8jin6oru	164	9	-	-	HYPH
cord-263157-8jin6oru	164	10	nucleotide	nucleotide	NN
cord-263157-8jin6oru	164	11	substitutions	substitution	NNS
cord-263157-8jin6oru	164	12	in	in	IN
cord-263157-8jin6oru	164	13	all	all	DT
cord-263157-8jin6oru	164	14	19	19	CD
cord-263157-8jin6oru	164	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	164	16	residues	residue	NNS
cord-263157-8jin6oru	164	17	targeted	target	VBN
cord-263157-8jin6oru	164	18	by	by	IN
cord-263157-8jin6oru	164	19	an	an	DT
cord-263157-8jin6oru	164	20	effective	effective	JJ
cord-263157-8jin6oru	164	21	siRNA	siRNA	NNP
cord-263157-8jin6oru	164	22	directed	direct	VBN
cord-263157-8jin6oru	164	23	against	against	IN
cord-263157-8jin6oru	164	24	the	the	DT
cord-263157-8jin6oru	164	25	RT	RT	NNP
cord-263157-8jin6oru	164	26	coding	coding	NN
cord-263157-8jin6oru	164	27	region	region	NN
cord-263157-8jin6oru	164	28	.	.	.
cord-263157-8jin6oru	165	1	All	all	DT
cord-263157-8jin6oru	165	2	mutant	mutant	JJ
cord-263157-8jin6oru	165	3	viruses	virus	NNS
cord-263157-8jin6oru	165	4	that	that	WDT
cord-263157-8jin6oru	165	5	were	be	VBD
cord-263157-8jin6oru	165	6	tested	test	VBN
cord-263157-8jin6oru	165	7	replicated	replicate	VBN
cord-263157-8jin6oru	165	8	better	well	RBR
cord-263157-8jin6oru	165	9	in	in	IN
cord-263157-8jin6oru	165	10	the	the	DT
cord-263157-8jin6oru	165	11	presence	presence	NN
cord-263157-8jin6oru	165	12	of	of	IN
cord-263157-8jin6oru	165	13	the	the	DT
cord-263157-8jin6oru	165	14	siRNA	siRNA	NNP
cord-263157-8jin6oru	165	15	-	-	HYPH
cord-263157-8jin6oru	165	16	RT	RT	NNP
cord-263157-8jin6oru	165	17	than	than	IN
cord-263157-8jin6oru	165	18	in	in	IN
cord-263157-8jin6oru	165	19	the	the	DT
cord-263157-8jin6oru	165	20	presence	presence	NN
cord-263157-8jin6oru	165	21	of	of	IN
cord-263157-8jin6oru	165	22	the	the	DT
cord-263157-8jin6oru	165	23	wild	wild	JJ
cord-263157-8jin6oru	165	24	type	type	NN
cord-263157-8jin6oru	165	25	virus	virus	NN
cord-263157-8jin6oru	165	26	.	.	.
cord-263157-8jin6oru	166	1	The	the	DT
cord-263157-8jin6oru	166	2	antiviral	antiviral	JJ
cord-263157-8jin6oru	166	3	activity	activity	NN
cord-263157-8jin6oru	166	4	of	of	IN
cord-263157-8jin6oru	166	5	the	the	DT
cord-263157-8jin6oru	166	6	siRNA	siRNA	NNP
cord-263157-8jin6oru	166	7	-	-	HYPH
cord-263157-8jin6oru	166	8	RT	RT	NNP
cord-263157-8jin6oru	166	9	was	be	VBD
cord-263157-8jin6oru	166	10	completely	completely	RB
cord-263157-8jin6oru	166	11	abolished	abolish	VBN
cord-263157-8jin6oru	166	12	by	by	IN
cord-263157-8jin6oru	166	13	single	single	JJ
cord-263157-8jin6oru	166	14	substitutions	substitution	NNS
cord-263157-8jin6oru	166	15	in	in	IN
cord-263157-8jin6oru	166	16	10	10	CD
cord-263157-8jin6oru	166	17	(	(	-LRB-
cord-263157-8jin6oru	166	18	positions	position	NNS
cord-263157-8jin6oru	166	19	4	4	CD
cord-263157-8jin6oru	166	20	to	to	IN
cord-263157-8jin6oru	166	21	11	11	CD
cord-263157-8jin6oru	166	22	,	,	,
cord-263157-8jin6oru	166	23	14	14	CD
cord-263157-8jin6oru	166	24	,	,	,
cord-263157-8jin6oru	166	25	and	and	CC
cord-263157-8jin6oru	166	26	15	15	CD
cord-263157-8jin6oru	166	27	)	)	-RRB-
cord-263157-8jin6oru	166	28	out	out	IN
cord-263157-8jin6oru	166	29	of	of	IN
cord-263157-8jin6oru	166	30	16	16	CD
cord-263157-8jin6oru	166	31	positions	position	NNS
cord-263157-8jin6oru	166	32	tested	test	VBN
cord-263157-8jin6oru	166	33	(	(	-LRB-
cord-263157-8jin6oru	166	34	substitutions	substitution	NNS
cord-263157-8jin6oru	166	35	at	at	IN
cord-263157-8jin6oru	166	36	3	3	CD
cord-263157-8jin6oru	166	37	of	of	IN
cord-263157-8jin6oru	166	38	the	the	DT
cord-263157-8jin6oru	166	39	19	19	CD
cord-263157-8jin6oru	166	40	positions	position	NNS
cord-263157-8jin6oru	166	41	rendered	render	VBN
cord-263157-8jin6oru	166	42	nonviable	nonviable	JJ
cord-263157-8jin6oru	166	43	viruses	virus	NNS
cord-263157-8jin6oru	166	44	)	)	-RRB-
cord-263157-8jin6oru	166	45	.	.	.
cord-263157-8jin6oru	167	1	With	with	IN
cord-263157-8jin6oru	167	2	the	the	DT
cord-263157-8jin6oru	167	3	exception	exception	NN
cord-263157-8jin6oru	167	4	of	of	IN
cord-263157-8jin6oru	167	5	one	one	CD
cord-263157-8jin6oru	167	6	substitution	substitution	NN
cord-263157-8jin6oru	167	7	,	,	,
cord-263157-8jin6oru	167	8	substitutions	substitution	NNS
cord-263157-8jin6oru	167	9	at	at	IN
cord-263157-8jin6oru	167	10	either	either	CC
cord-263157-8jin6oru	167	11	the	the	DT
cord-263157-8jin6oru	167	12	5	5	CD
cord-263157-8jin6oru	167	13	′	′	CD
cord-263157-8jin6oru	167	14	or	or	CC
cord-263157-8jin6oru	167	15	3	3	CD
cord-263157-8jin6oru	167	16	′	′	CD
cord-263157-8jin6oru	167	17	end	end	NN
cord-263157-8jin6oru	167	18	were	be	VBD
cord-263157-8jin6oru	167	19	better	well	RBR
cord-263157-8jin6oru	167	20	tolerated	tolerate	VBN
cord-263157-8jin6oru	167	21	by	by	IN
cord-263157-8jin6oru	167	22	the	the	DT
cord-263157-8jin6oru	167	23	RNA	RNA	NNP
cord-263157-8jin6oru	167	24	interference	interference	NN
cord-263157-8jin6oru	167	25	machinery	machinery	NN
cord-263157-8jin6oru	167	26	and	and	CC
cord-263157-8jin6oru	167	27	only	only	RB
cord-263157-8jin6oru	167	28	partially	partially	RB
cord-263157-8jin6oru	167	29	affected	affect	VBN
cord-263157-8jin6oru	167	30	siRNA	siRNA	NNP
cord-263157-8jin6oru	167	31	-	-	HYPH
cord-263157-8jin6oru	167	32	RT	RT	NNP
cord-263157-8jin6oru	167	33	inhibition	inhibition	NN
cord-263157-8jin6oru	167	34	.	.	.
cord-263157-8jin6oru	168	1	Since	since	IN
cord-263157-8jin6oru	168	2	the	the	DT
cord-263157-8jin6oru	168	3	emergence	emergence	NN
cord-263157-8jin6oru	168	4	of	of	IN
cord-263157-8jin6oru	168	5	resistant	resistant	JJ
cord-263157-8jin6oru	168	6	virus	virus	NN
cord-263157-8jin6oru	168	7	variants	variant	NNS
cord-263157-8jin6oru	168	8	poses	pose	VBZ
cord-263157-8jin6oru	168	9	a	a	DT
cord-263157-8jin6oru	168	10	serious	serious	JJ
cord-263157-8jin6oru	168	11	problem	problem	NN
cord-263157-8jin6oru	168	12	for	for	IN
cord-263157-8jin6oru	168	13	using	use	VBG
cord-263157-8jin6oru	168	14	RNAi	RNAi	NNS
cord-263157-8jin6oru	168	15	in	in	IN
cord-263157-8jin6oru	168	16	a	a	DT
cord-263157-8jin6oru	168	17	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	168	18	setting	setting	NN
cord-263157-8jin6oru	168	19	,	,	,
cord-263157-8jin6oru	168	20	different	different	JJ
cord-263157-8jin6oru	168	21	strategies	strategy	NNS
cord-263157-8jin6oru	168	22	have	have	VBP
cord-263157-8jin6oru	168	23	been	be	VBN
cord-263157-8jin6oru	168	24	developed	develop	VBN
cord-263157-8jin6oru	168	25	to	to	TO
cord-263157-8jin6oru	168	26	counteract	counteract	VB
cord-263157-8jin6oru	168	27	viral	viral	JJ
cord-263157-8jin6oru	168	28	escape	escape	NN
cord-263157-8jin6oru	168	29	.	.	.
cord-263157-8jin6oru	169	1	One	one	CD
cord-263157-8jin6oru	169	2	obvious	obvious	JJ
cord-263157-8jin6oru	169	3	strategy	strategy	NN
cord-263157-8jin6oru	169	4	that	that	WDT
cord-263157-8jin6oru	169	5	will	will	MD
cord-263157-8jin6oru	169	6	successfully	successfully	RB
cord-263157-8jin6oru	169	7	both	both	DT
cord-263157-8jin6oru	169	8	inhibit	inhibit	VB
cord-263157-8jin6oru	169	9	a	a	DT
cord-263157-8jin6oru	169	10	diversity	diversity	NN
cord-263157-8jin6oru	169	11	of	of	IN
cord-263157-8jin6oru	169	12	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	169	13	isolates	isolate	NNS
cord-263157-8jin6oru	169	14	and	and	CC
cord-263157-8jin6oru	169	15	protect	protect	VB
cord-263157-8jin6oru	169	16	against	against	IN
cord-263157-8jin6oru	169	17	the	the	DT
cord-263157-8jin6oru	169	18	emergence	emergence	NN
cord-263157-8jin6oru	169	19	of	of	IN
cord-263157-8jin6oru	169	20	viral	viral	JJ
cord-263157-8jin6oru	169	21	escape	escape	NN
cord-263157-8jin6oru	169	22	would	would	MD
cord-263157-8jin6oru	169	23	be	be	VB
cord-263157-8jin6oru	169	24	to	to	TO
cord-263157-8jin6oru	169	25	identify	identify	VB
cord-263157-8jin6oru	169	26	viral	viral	JJ
cord-263157-8jin6oru	169	27	conserved	conserve	VBN
cord-263157-8jin6oru	169	28	sequences	sequence	NNS
cord-263157-8jin6oru	169	29	for	for	IN
cord-263157-8jin6oru	169	30	targeting	target	VBG
cord-263157-8jin6oru	169	31	.	.	.
cord-263157-8jin6oru	170	1	Targeting	target	VBG
cord-263157-8jin6oru	170	2	highly	highly	RB
cord-263157-8jin6oru	170	3	conserved	conserve	VBN
cord-263157-8jin6oru	170	4	sequences	sequence	NNS
cord-263157-8jin6oru	170	5	may	may	MD
cord-263157-8jin6oru	170	6	hamper	hamper	VB
cord-263157-8jin6oru	170	7	the	the	DT
cord-263157-8jin6oru	170	8	development	development	NN
cord-263157-8jin6oru	170	9	of	of	IN
cord-263157-8jin6oru	170	10	escape	escape	NN
cord-263157-8jin6oru	170	11	mutants	mutant	NNS
cord-263157-8jin6oru	170	12	,	,	,
cord-263157-8jin6oru	170	13	as	as	IN
cord-263157-8jin6oru	170	14	these	these	DT
cord-263157-8jin6oru	170	15	variants	variant	NNS
cord-263157-8jin6oru	170	16	may	may	MD
cord-263157-8jin6oru	170	17	be	be	VB
cord-263157-8jin6oru	170	18	highly	highly	RB
cord-263157-8jin6oru	170	19	compromised	compromise	VBN
cord-263157-8jin6oru	170	20	for	for	IN
cord-263157-8jin6oru	170	21	viral	viral	JJ
cord-263157-8jin6oru	170	22	fitness	fitness	NN
cord-263157-8jin6oru	170	23	.	.	.
cord-263157-8jin6oru	171	1	Indeed	indeed	RB
cord-263157-8jin6oru	171	2	,	,	,
cord-263157-8jin6oru	171	3	Lee	Lee	NNP
cord-263157-8jin6oru	171	4	et	et	NNP
cord-263157-8jin6oru	171	5	al	al	NNP
cord-263157-8jin6oru	171	6	.	.	.
cord-263157-8jin6oru	172	1	(	(	-LRB-
cord-263157-8jin6oru	172	2	37	37	CD
cord-263157-8jin6oru	172	3	)	)	-RRB-
cord-263157-8jin6oru	172	4	targeted	target	VBD
cord-263157-8jin6oru	172	5	highly	highly	RB
cord-263157-8jin6oru	172	6	conserved	conserve	VBN
cord-263157-8jin6oru	172	7	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	172	8	Vif	Vif	NNP
cord-263157-8jin6oru	172	9	sequences	sequence	NNS
cord-263157-8jin6oru	172	10	and	and	CC
cord-263157-8jin6oru	172	11	successfully	successfully	RB
cord-263157-8jin6oru	172	12	suppressed	suppress	VBD
cord-263157-8jin6oru	172	13	a	a	DT
cord-263157-8jin6oru	172	14	variety	variety	NN
cord-263157-8jin6oru	172	15	of	of	IN
cord-263157-8jin6oru	172	16	primary	primary	JJ
cord-263157-8jin6oru	172	17	viral	viral	JJ
cord-263157-8jin6oru	172	18	isolates	isolate	NNS
cord-263157-8jin6oru	172	19	from	from	IN
cord-263157-8jin6oru	172	20	five	five	CD
cord-263157-8jin6oru	172	21	different	different	JJ
cord-263157-8jin6oru	172	22	viral	viral	JJ
cord-263157-8jin6oru	172	23	clades	clade	NNS
cord-263157-8jin6oru	172	24	.	.	.
cord-263157-8jin6oru	173	1	This	this	DT
cord-263157-8jin6oru	173	2	study	study	NN
cord-263157-8jin6oru	173	3	also	also	RB
cord-263157-8jin6oru	173	4	showed	show	VBD
cord-263157-8jin6oru	173	5	that	that	IN
cord-263157-8jin6oru	173	6	tolerance	tolerance	NN
cord-263157-8jin6oru	173	7	to	to	TO
cord-263157-8jin6oru	173	8	target	target	VB
cord-263157-8jin6oru	173	9	sequence	sequence	NN
cord-263157-8jin6oru	173	10	mismatches	mismatch	NNS
cord-263157-8jin6oru	173	11	may	may	MD
cord-263157-8jin6oru	173	12	depend	depend	VB
cord-263157-8jin6oru	173	13	on	on	IN
cord-263157-8jin6oru	173	14	the	the	DT
cord-263157-8jin6oru	173	15	sequence	sequence	NN
cord-263157-8jin6oru	173	16	of	of	IN
cord-263157-8jin6oru	173	17	the	the	DT
cord-263157-8jin6oru	173	18	siRNA	siRNA	NNP
cord-263157-8jin6oru	173	19	tested	test	VBN
cord-263157-8jin6oru	173	20	(	(	-LRB-
cord-263157-8jin6oru	173	21	37	37	CD
cord-263157-8jin6oru	173	22	)	)	-RRB-
cord-263157-8jin6oru	173	23	.	.	.
cord-263157-8jin6oru	174	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	174	2	,	,	,
cord-263157-8jin6oru	174	3	our	-PRON-	PRP$
cord-263157-8jin6oru	174	4	knowledge	knowledge	NN
cord-263157-8jin6oru	174	5	of	of	IN
cord-263157-8jin6oru	174	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	174	7	variability	variability	NN
cord-263157-8jin6oru	174	8	and	and	CC
cord-263157-8jin6oru	174	9	experience	experience	NN
cord-263157-8jin6oru	174	10	from	from	IN
cord-263157-8jin6oru	174	11	over	over	IN
cord-263157-8jin6oru	174	12	one	one	CD
cord-263157-8jin6oru	174	13	decade	decade	NN
cord-263157-8jin6oru	174	14	of	of	IN
cord-263157-8jin6oru	174	15	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	174	16	therapy	therapy	NN
cord-263157-8jin6oru	174	17	have	have	VBP
cord-263157-8jin6oru	174	18	taught	teach	VBN
cord-263157-8jin6oru	174	19	us	-PRON-	PRP
cord-263157-8jin6oru	174	20	that	that	WDT
cord-263157-8jin6oru	174	21	is	be	VBZ
cord-263157-8jin6oru	174	22	unrealistic	unrealistic	JJ
cord-263157-8jin6oru	174	23	to	to	TO
cord-263157-8jin6oru	174	24	try	try	VB
cord-263157-8jin6oru	174	25	to	to	TO
cord-263157-8jin6oru	174	26	target	target	VB
cord-263157-8jin6oru	174	27	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	174	28	with	with	IN
cord-263157-8jin6oru	174	29	a	a	DT
cord-263157-8jin6oru	174	30	unique	unique	JJ
cord-263157-8jin6oru	174	31	siRNA	sirna	NN
cord-263157-8jin6oru	174	32	because	because	IN
cord-263157-8jin6oru	174	33	the	the	DT
cord-263157-8jin6oru	174	34	rapid	rapid	JJ
cord-263157-8jin6oru	174	35	development	development	NN
cord-263157-8jin6oru	174	36	of	of	IN
cord-263157-8jin6oru	174	37	resistance	resistance	NN
cord-263157-8jin6oru	174	38	will	will	MD
cord-263157-8jin6oru	174	39	occur	occur	VB
cord-263157-8jin6oru	174	40	.	.	.
cord-263157-8jin6oru	175	1	The	the	DT
cord-263157-8jin6oru	175	2	high	high	JJ
cord-263157-8jin6oru	175	3	error	error	NN
cord-263157-8jin6oru	175	4	rate	rate	NN
cord-263157-8jin6oru	175	5	of	of	IN
cord-263157-8jin6oru	175	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	175	7	RT	RT	NNP
cord-263157-8jin6oru	175	8	and	and	CC
cord-263157-8jin6oru	175	9	the	the	DT
cord-263157-8jin6oru	175	10	rapid	rapid	JJ
cord-263157-8jin6oru	175	11	viral	viral	JJ
cord-263157-8jin6oru	175	12	turnover	turnover	NN
cord-263157-8jin6oru	175	13	means	mean	VBZ
cord-263157-8jin6oru	175	14	that	that	IN
cord-263157-8jin6oru	175	15	for	for	IN
cord-263157-8jin6oru	175	16	each	each	DT
cord-263157-8jin6oru	175	17	of	of	IN
cord-263157-8jin6oru	175	18	the	the	DT
cord-263157-8jin6oru	175	19	19	19	CD
cord-263157-8jin6oru	175	20	nucleotides	nucleotide	NNS
cord-263157-8jin6oru	175	21	targeted	target	VBN
cord-263157-8jin6oru	175	22	by	by	IN
cord-263157-8jin6oru	175	23	an	an	DT
cord-263157-8jin6oru	175	24	si	si	NN
cord-263157-8jin6oru	175	25	-	-	:
cord-263157-8jin6oru	175	26	or	or	CC
cord-263157-8jin6oru	175	27	shRNA	shrna	NN
cord-263157-8jin6oru	175	28	,	,	,
cord-263157-8jin6oru	175	29	several	several	JJ
cord-263157-8jin6oru	175	30	potential	potential	JJ
cord-263157-8jin6oru	175	31	escape	escape	NN
cord-263157-8jin6oru	175	32	variants	variant	NNS
cord-263157-8jin6oru	175	33	will	will	MD
cord-263157-8jin6oru	175	34	be	be	VB
cord-263157-8jin6oru	175	35	already	already	RB
cord-263157-8jin6oru	175	36	present	present	JJ
cord-263157-8jin6oru	175	37	before	before	IN
cord-263157-8jin6oru	175	38	the	the	DT
cord-263157-8jin6oru	175	39	start	start	NN
cord-263157-8jin6oru	175	40	of	of	IN
cord-263157-8jin6oru	175	41	therapy	therapy	NN
cord-263157-8jin6oru	175	42	(	(	-LRB-
cord-263157-8jin6oru	175	43	57	57	CD
cord-263157-8jin6oru	175	44	)	)	-RRB-
cord-263157-8jin6oru	175	45	.	.	.
cord-263157-8jin6oru	176	1	Moreover	moreover	RB
cord-263157-8jin6oru	176	2	,	,	,
cord-263157-8jin6oru	176	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	176	4	may	may	MD
cord-263157-8jin6oru	176	5	escape	escape	VB
cord-263157-8jin6oru	176	6	RNAi	RNAi	NNS
cord-263157-8jin6oru	176	7	through	through	IN
cord-263157-8jin6oru	176	8	silent	silent	JJ
cord-263157-8jin6oru	176	9	mutations	mutation	NNS
cord-263157-8jin6oru	176	10	,	,	,
cord-263157-8jin6oru	176	11	which	which	WDT
cord-263157-8jin6oru	176	12	,	,	,
cord-263157-8jin6oru	176	13	in	in	IN
cord-263157-8jin6oru	176	14	most	most	JJS
cord-263157-8jin6oru	176	15	cases	case	NNS
cord-263157-8jin6oru	176	16	,	,	,
cord-263157-8jin6oru	176	17	will	will	MD
cord-263157-8jin6oru	176	18	not	not	RB
cord-263157-8jin6oru	176	19	have	have	VB
cord-263157-8jin6oru	176	20	any	any	DT
cord-263157-8jin6oru	176	21	cost	cost	NN
cord-263157-8jin6oru	176	22	on	on	IN
cord-263157-8jin6oru	176	23	the	the	DT
cord-263157-8jin6oru	176	24	viral	viral	JJ
cord-263157-8jin6oru	176	25	fitness	fitness	NN
cord-263157-8jin6oru	176	26	.	.	.
cord-263157-8jin6oru	177	1	To	to	TO
cord-263157-8jin6oru	177	2	counteract	counteract	VB
cord-263157-8jin6oru	177	3	this	this	DT
cord-263157-8jin6oru	177	4	strategic	strategic	JJ
cord-263157-8jin6oru	177	5	weakness	weakness	NN
cord-263157-8jin6oru	177	6	,	,	,
cord-263157-8jin6oru	177	7	co	co	NN
cord-263157-8jin6oru	177	8	-	-	NN
cord-263157-8jin6oru	177	9	expression	expression	NN
cord-263157-8jin6oru	177	10	of	of	IN
cord-263157-8jin6oru	177	11	multiple	multiple	JJ
cord-263157-8jin6oru	177	12	siRNAs	sirna	NNS
cord-263157-8jin6oru	177	13	or	or	CC
cord-263157-8jin6oru	177	14	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	177	15	that	that	WDT
cord-263157-8jin6oru	177	16	target	target	NN
cord-263157-8jin6oru	177	17	conserved	conserve	VBN
cord-263157-8jin6oru	177	18	RNA	RNA	NNP
cord-263157-8jin6oru	177	19	sequences	sequence	NNS
cord-263157-8jin6oru	177	20	could	could	MD
cord-263157-8jin6oru	177	21	reduce	reduce	VB
cord-263157-8jin6oru	177	22	the	the	DT
cord-263157-8jin6oru	177	23	emergence	emergence	NN
cord-263157-8jin6oru	177	24	of	of	IN
cord-263157-8jin6oru	177	25	single	single	JJ
cord-263157-8jin6oru	177	26	siRNA	sirna	JJ
cord-263157-8jin6oru	177	27	-	-	HYPH
cord-263157-8jin6oru	177	28	resistant	resistant	JJ
cord-263157-8jin6oru	177	29	virus	virus	NN
cord-263157-8jin6oru	177	30	with	with	IN
cord-263157-8jin6oru	177	31	a	a	DT
cord-263157-8jin6oru	177	32	comparable	comparable	JJ
cord-263157-8jin6oru	177	33	effect	effect	NN
cord-263157-8jin6oru	177	34	to	to	IN
cord-263157-8jin6oru	177	35	that	that	DT
cord-263157-8jin6oru	177	36	achieved	achieve	VBN
cord-263157-8jin6oru	177	37	by	by	IN
cord-263157-8jin6oru	177	38	the	the	DT
cord-263157-8jin6oru	177	39	multiple	multiple	JJ
cord-263157-8jin6oru	177	40	anti	anti	JJ
cord-263157-8jin6oru	177	41	-	-	JJ
cord-263157-8jin6oru	177	42	HIV	hiv	JJ
cord-263157-8jin6oru	177	43	drug	drug	NN
cord-263157-8jin6oru	177	44	combination	combination	NN
cord-263157-8jin6oru	177	45	approach	approach	NN
cord-263157-8jin6oru	177	46	employed	employ	VBN
cord-263157-8jin6oru	177	47	by	by	IN
cord-263157-8jin6oru	177	48	HAART	HAART	NNP
cord-263157-8jin6oru	177	49	.	.	.
cord-263157-8jin6oru	178	1	Delivery	delivery	NN
cord-263157-8jin6oru	178	2	of	of	IN
cord-263157-8jin6oru	178	3	multiple	multiple	JJ
cord-263157-8jin6oru	178	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	178	5	could	could	MD
cord-263157-8jin6oru	178	6	induce	induce	VB
cord-263157-8jin6oru	178	7	highly	highly	RB
cord-263157-8jin6oru	178	8	active	active	JJ
cord-263157-8jin6oru	178	9	antiretroviral	antiretroviral	JJ
cord-263157-8jin6oru	178	10	gene	gene	NN
cord-263157-8jin6oru	178	11	silencing	silencing	NN
cord-263157-8jin6oru	178	12	(	(	-LRB-
cord-263157-8jin6oru	178	13	HAAGS	HAAGS	NNP
cord-263157-8jin6oru	178	14	)	)	-RRB-
cord-263157-8jin6oru	178	15	(	(	-LRB-
cord-263157-8jin6oru	178	16	61	61	CD
cord-263157-8jin6oru	178	17	)	)	-RRB-
cord-263157-8jin6oru	178	18	.	.	.
cord-263157-8jin6oru	179	1	The	the	DT
cord-263157-8jin6oru	179	2	combination	combination	NN
cord-263157-8jin6oru	179	3	of	of	IN
cord-263157-8jin6oru	179	4	multiple	multiple	JJ
cord-263157-8jin6oru	179	5	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	179	6	against	against	IN
cord-263157-8jin6oru	179	7	conserved	conserve	VBN
cord-263157-8jin6oru	179	8	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	179	9	genomic	genomic	JJ
cord-263157-8jin6oru	179	10	regions	region	NNS
cord-263157-8jin6oru	179	11	effectively	effectively	RB
cord-263157-8jin6oru	179	12	inhibits	inhibit	VBZ
cord-263157-8jin6oru	179	13	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	179	14	replication	replication	NN
cord-263157-8jin6oru	179	15	.	.	.
cord-263157-8jin6oru	180	1	Expression	expression	NN
cord-263157-8jin6oru	180	2	of	of	IN
cord-263157-8jin6oru	180	3	three	three	CD
cord-263157-8jin6oru	180	4	different	different	JJ
cord-263157-8jin6oru	180	5	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	180	6	from	from	IN
cord-263157-8jin6oru	180	7	a	a	DT
cord-263157-8jin6oru	180	8	single	single	JJ
cord-263157-8jin6oru	180	9	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	180	10	vector	vector	NN
cord-263157-8jin6oru	180	11	resulted	result	VBD
cord-263157-8jin6oru	180	12	in	in	IN
cord-263157-8jin6oru	180	13	similar	similar	JJ
cord-263157-8jin6oru	180	14	levels	level	NNS
cord-263157-8jin6oru	180	15	of	of	IN
cord-263157-8jin6oru	180	16	inhibition	inhibition	NN
cord-263157-8jin6oru	180	17	per	per	IN
cord-263157-8jin6oru	180	18	shRNA	shrna	NN
cord-263157-8jin6oru	180	19	compared	compare	VBN
cord-263157-8jin6oru	180	20	to	to	IN
cord-263157-8jin6oru	180	21	single	single	JJ
cord-263157-8jin6oru	180	22	shRNA	shrna	NN
cord-263157-8jin6oru	180	23	vectors	vector	NNS
cord-263157-8jin6oru	180	24	(	(	-LRB-
cord-263157-8jin6oru	180	25	62	62	CD
cord-263157-8jin6oru	180	26	)	)	-RRB-
cord-263157-8jin6oru	180	27	.	.	.
cord-263157-8jin6oru	181	1	In	in	IN
cord-263157-8jin6oru	181	2	this	this	DT
cord-263157-8jin6oru	181	3	study	study	NN
cord-263157-8jin6oru	181	4	,	,	,
cord-263157-8jin6oru	181	5	the	the	DT
cord-263157-8jin6oru	181	6	three	three	CD
cord-263157-8jin6oru	181	7	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	181	8	targeted	target	VBN
cord-263157-8jin6oru	181	9	Gag	Gag	NNP
cord-263157-8jin6oru	181	10	and	and	CC
cord-263157-8jin6oru	181	11	Pol	Pol	NNP
cord-263157-8jin6oru	181	12	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	181	13	coding	code	VBG
cord-263157-8jin6oru	181	14	regions	region	NNS
cord-263157-8jin6oru	181	15	;	;	:
cord-263157-8jin6oru	181	16	moreover	moreover	RB
cord-263157-8jin6oru	181	17	,	,	,
cord-263157-8jin6oru	181	18	when	when	WRB
cord-263157-8jin6oru	181	19	cells	cell	NNS
cord-263157-8jin6oru	181	20	transduced	transduce	VBN
cord-263157-8jin6oru	181	21	with	with	IN
cord-263157-8jin6oru	181	22	a	a	DT
cord-263157-8jin6oru	181	23	double	double	JJ
cord-263157-8jin6oru	181	24	shRNA	shRNA	``
cord-263157-8jin6oru	181	25	viral	viral	JJ
cord-263157-8jin6oru	181	26	vector	vector	NN
cord-263157-8jin6oru	181	27	were	be	VBD
cord-263157-8jin6oru	181	28	infected	infect	VBN
cord-263157-8jin6oru	181	29	,	,	,
cord-263157-8jin6oru	181	30	virus	virus	NN
cord-263157-8jin6oru	181	31	escape	escape	NN
cord-263157-8jin6oru	181	32	was	be	VBD
cord-263157-8jin6oru	181	33	delayed	delay	VBN
cord-263157-8jin6oru	181	34	(	(	-LRB-
cord-263157-8jin6oru	181	35	62	62	CD
cord-263157-8jin6oru	181	36	)	)	-RRB-
cord-263157-8jin6oru	181	37	.	.	.
cord-263157-8jin6oru	182	1	There	there	EX
cord-263157-8jin6oru	182	2	are	be	VBP
cord-263157-8jin6oru	182	3	several	several	JJ
cord-263157-8jin6oru	182	4	methods	method	NNS
cord-263157-8jin6oru	182	5	currently	currently	RB
cord-263157-8jin6oru	182	6	in	in	IN
cord-263157-8jin6oru	182	7	use	use	NN
cord-263157-8jin6oru	182	8	that	that	WDT
cord-263157-8jin6oru	182	9	are	be	VBP
cord-263157-8jin6oru	182	10	capable	capable	JJ
cord-263157-8jin6oru	182	11	of	of	IN
cord-263157-8jin6oru	182	12	expressing	express	VBG
cord-263157-8jin6oru	182	13	multiple	multiple	JJ
cord-263157-8jin6oru	182	14	effective	effective	JJ
cord-263157-8jin6oru	182	15	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	182	16	.	.	.
cord-263157-8jin6oru	183	1	One	one	CD
cord-263157-8jin6oru	183	2	possibility	possibility	NN
cord-263157-8jin6oru	183	3	is	be	VBZ
cord-263157-8jin6oru	183	4	by	by	IN
cord-263157-8jin6oru	183	5	inserting	insert	VBG
cord-263157-8jin6oru	183	6	multiple	multiple	JJ
cord-263157-8jin6oru	183	7	shRNA	shrna	JJ
cord-263157-8jin6oru	183	8	-	-	HYPH
cord-263157-8jin6oru	183	9	expression	expression	NN
cord-263157-8jin6oru	183	10	cassettes	cassette	NNS
cord-263157-8jin6oru	183	11	into	into	IN
cord-263157-8jin6oru	183	12	a	a	DT
cord-263157-8jin6oru	183	13	viral	viral	JJ
cord-263157-8jin6oru	183	14	vector	vector	NN
cord-263157-8jin6oru	183	15	.	.	.
cord-263157-8jin6oru	184	1	However	however	RB
cord-263157-8jin6oru	184	2	,	,	,
cord-263157-8jin6oru	184	3	repeats	repeat	VBZ
cord-263157-8jin6oru	184	4	of	of	IN
cord-263157-8jin6oru	184	5	the	the	DT
cord-263157-8jin6oru	184	6	same	same	JJ
cord-263157-8jin6oru	184	7	regulatory	regulatory	JJ
cord-263157-8jin6oru	184	8	sequences	sequence	NNS
cord-263157-8jin6oru	184	9	(	(	-LRB-
cord-263157-8jin6oru	184	10	e.g.	e.g.	RB
cord-263157-8jin6oru	184	11	,	,	,
cord-263157-8jin6oru	184	12	the	the	DT
cord-263157-8jin6oru	184	13	U6	U6	NNP
cord-263157-8jin6oru	184	14	or	or	CC
cord-263157-8jin6oru	184	15	H1	H1	NNP
cord-263157-8jin6oru	184	16	polymerase	polymerase	NN
cord-263157-8jin6oru	184	17	III	iii	CD
cord-263157-8jin6oru	184	18	promoter	promoter	NN
cord-263157-8jin6oru	184	19	)	)	-RRB-
cord-263157-8jin6oru	184	20	may	may	MD
cord-263157-8jin6oru	184	21	cause	cause	VB
cord-263157-8jin6oru	184	22	genetic	genetic	JJ
cord-263157-8jin6oru	184	23	instability	instability	NN
cord-263157-8jin6oru	184	24	and	and	CC
cord-263157-8jin6oru	184	25	reduced	reduce	VBN
cord-263157-8jin6oru	184	26	titer	titer	NN
cord-263157-8jin6oru	184	27	of	of	IN
cord-263157-8jin6oru	184	28	the	the	DT
cord-263157-8jin6oru	184	29	vector	vector	NN
cord-263157-8jin6oru	184	30	system	system	NN
cord-263157-8jin6oru	184	31	(	(	-LRB-
cord-263157-8jin6oru	184	32	63	63	CD
cord-263157-8jin6oru	184	33	)	)	-RRB-
cord-263157-8jin6oru	184	34	.	.	.
cord-263157-8jin6oru	185	1	Moreover	moreover	RB
cord-263157-8jin6oru	185	2	,	,	,
cord-263157-8jin6oru	185	3	some	some	DT
cord-263157-8jin6oru	185	4	studies	study	NNS
cord-263157-8jin6oru	185	5	have	have	VBP
cord-263157-8jin6oru	185	6	shown	show	VBN
cord-263157-8jin6oru	185	7	that	that	IN
cord-263157-8jin6oru	185	8	it	-PRON-	PRP
cord-263157-8jin6oru	185	9	is	be	VBZ
cord-263157-8jin6oru	185	10	possible	possible	JJ
cord-263157-8jin6oru	185	11	to	to	TO
cord-263157-8jin6oru	185	12	saturate	saturate	VB
cord-263157-8jin6oru	185	13	the	the	DT
cord-263157-8jin6oru	185	14	RNAi	RNAi	NNP
cord-263157-8jin6oru	185	15	pathway	pathway	NN
cord-263157-8jin6oru	185	16	by	by	IN
cord-263157-8jin6oru	185	17	high	high	JJ
cord-263157-8jin6oru	185	18	levels	level	NNS
cord-263157-8jin6oru	185	19	of	of	IN
cord-263157-8jin6oru	185	20	expression	expression	NN
cord-263157-8jin6oru	185	21	of	of	IN
cord-263157-8jin6oru	185	22	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	185	23	(	(	-LRB-
cord-263157-8jin6oru	185	24	64	64	CD
cord-263157-8jin6oru	185	25	,	,	,
cord-263157-8jin6oru	185	26	65	65	CD
cord-263157-8jin6oru	185	27	)	)	-RRB-
cord-263157-8jin6oru	185	28	resulting	result	VBG
cord-263157-8jin6oru	185	29	in	in	IN
cord-263157-8jin6oru	185	30	cellular	cellular	JJ
cord-263157-8jin6oru	185	31	toxicity	toxicity	NN
cord-263157-8jin6oru	185	32	,	,	,
cord-263157-8jin6oru	185	33	particularly	particularly	RB
cord-263157-8jin6oru	185	34	with	with	IN
cord-263157-8jin6oru	185	35	the	the	DT
cord-263157-8jin6oru	185	36	U6	U6	NNP
cord-263157-8jin6oru	185	37	promoter	promoter	NN
cord-263157-8jin6oru	185	38	[	[	-LRB-
cord-263157-8jin6oru	185	39	64	64	CD
cord-263157-8jin6oru	185	40	]	]	-RRB-
cord-263157-8jin6oru	185	41	.	.	.
cord-263157-8jin6oru	186	1	Polymerase	Polymerase	NNP
cord-263157-8jin6oru	186	2	III	iii	CD
cord-263157-8jin6oru	186	3	promoters	promoter	NNS
cord-263157-8jin6oru	186	4	other	other	JJ
cord-263157-8jin6oru	186	5	than	than	IN
cord-263157-8jin6oru	186	6	U6	U6	NNP
cord-263157-8jin6oru	186	7	and	and	CC
cord-263157-8jin6oru	186	8	H1	H1	NNP
cord-263157-8jin6oru	186	9	has	have	VBZ
cord-263157-8jin6oru	186	10	been	be	VBN
cord-263157-8jin6oru	186	11	used	use	VBN
cord-263157-8jin6oru	186	12	(	(	-LRB-
cord-263157-8jin6oru	186	13	66	66	CD
cord-263157-8jin6oru	186	14	)	)	-RRB-
cord-263157-8jin6oru	186	15	.	.	.
cord-263157-8jin6oru	187	1	Another	another	DT
cord-263157-8jin6oru	187	2	approach	approach	NN
cord-263157-8jin6oru	187	3	has	have	VBZ
cord-263157-8jin6oru	187	4	been	be	VBN
cord-263157-8jin6oru	187	5	the	the	DT
cord-263157-8jin6oru	187	6	use	use	NN
cord-263157-8jin6oru	187	7	of	of	IN
cord-263157-8jin6oru	187	8	long	long	JJ
cord-263157-8jin6oru	187	9	-	-	HYPH
cord-263157-8jin6oru	187	10	hairpin	hairpin	NN
cord-263157-8jin6oru	187	11	RNAs	rna	NNS
cord-263157-8jin6oru	187	12	(	(	-LRB-
cord-263157-8jin6oru	187	13	lhRNAs	lhRNAs	NNP
cord-263157-8jin6oru	187	14	)	)	-RRB-
cord-263157-8jin6oru	187	15	,	,	,
cord-263157-8jin6oru	187	16	from	from	IN
cord-263157-8jin6oru	187	17	which	which	WDT
cord-263157-8jin6oru	187	18	multiple	multiple	JJ
cord-263157-8jin6oru	187	19	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	187	20	can	can	MD
cord-263157-8jin6oru	187	21	be	be	VB
cord-263157-8jin6oru	187	22	produced	produce	VBN
cord-263157-8jin6oru	187	23	.	.	.
cord-263157-8jin6oru	188	1	lhRNAs	lhRNAs	NNP
cord-263157-8jin6oru	188	2	greater	great	JJR
cord-263157-8jin6oru	188	3	than	than	IN
cord-263157-8jin6oru	188	4	50	50	CD
cord-263157-8jin6oru	188	5	bp	bp	NNS
cord-263157-8jin6oru	188	6	in	in	IN
cord-263157-8jin6oru	188	7	length	length	NN
cord-263157-8jin6oru	188	8	can	can	MD
cord-263157-8jin6oru	188	9	be	be	VB
cord-263157-8jin6oru	188	10	expressed	express	VBN
cord-263157-8jin6oru	188	11	in	in	IN
cord-263157-8jin6oru	188	12	cells	cell	NNS
cord-263157-8jin6oru	188	13	and	and	CC
cord-263157-8jin6oru	188	14	create	create	VB
cord-263157-8jin6oru	188	15	multiple	multiple	JJ
cord-263157-8jin6oru	188	16	siRNAs	sirnas	NN
cord-263157-8jin6oru	188	17	via	via	IN
cord-263157-8jin6oru	188	18	Dicer	dicer	NN
cord-263157-8jin6oru	188	19	-	-	HYPH
cord-263157-8jin6oru	188	20	mediated	mediate	VBN
cord-263157-8jin6oru	188	21	processing	processing	NN
cord-263157-8jin6oru	188	22	without	without	IN
cord-263157-8jin6oru	188	23	inducing	induce	VBG
cord-263157-8jin6oru	188	24	the	the	DT
cord-263157-8jin6oru	188	25	IFN	IFN	NNP
cord-263157-8jin6oru	188	26	pathway	pathway	NN
cord-263157-8jin6oru	188	27	(	(	-LRB-
cord-263157-8jin6oru	188	28	67	67	CD
cord-263157-8jin6oru	188	29	)	)	-RRB-
cord-263157-8jin6oru	188	30	.	.	.
cord-263157-8jin6oru	189	1	Several	several	JJ
cord-263157-8jin6oru	189	2	reports	report	NNS
cord-263157-8jin6oru	189	3	described	describe	VBD
cord-263157-8jin6oru	189	4	efficient	efficient	JJ
cord-263157-8jin6oru	189	5	RNAi	RNAi	NNS
cord-263157-8jin6oru	189	6	induction	induction	NN
cord-263157-8jin6oru	189	7	by	by	IN
cord-263157-8jin6oru	189	8	lhRNAs	lhRNAs	NNP
cord-263157-8jin6oru	189	9	against	against	IN
cord-263157-8jin6oru	189	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	189	11	(	(	-LRB-
cord-263157-8jin6oru	189	12	68	68	CD
cord-263157-8jin6oru	189	13	,	,	,
cord-263157-8jin6oru	189	14	69	69	CD
cord-263157-8jin6oru	189	15	)	)	-RRB-
cord-263157-8jin6oru	189	16	.	.	.
cord-263157-8jin6oru	190	1	Nishitsuji	Nishitsuji	NNP
cord-263157-8jin6oru	190	2	et	et	NNP
cord-263157-8jin6oru	190	3	al	al	NNP
cord-263157-8jin6oru	190	4	.	.	.
cord-263157-8jin6oru	191	1	(	(	-LRB-
cord-263157-8jin6oru	191	2	69	69	CD
cord-263157-8jin6oru	191	3	)	)	-RRB-
cord-263157-8jin6oru	191	4	showed	show	VBD
cord-263157-8jin6oru	191	5	that	that	IN
cord-263157-8jin6oru	191	6	a	a	DT
cord-263157-8jin6oru	191	7	50	50	CD
cord-263157-8jin6oru	191	8	bp	bp	NNP
cord-263157-8jin6oru	191	9	lhRNA	lhRNA	NNP
cord-263157-8jin6oru	191	10	against	against	IN
cord-263157-8jin6oru	191	11	a	a	DT
cord-263157-8jin6oru	191	12	conserved	conserve	VBN
cord-263157-8jin6oru	191	13	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	191	14	integrase	integrase	NN
cord-263157-8jin6oru	191	15	region	region	NN
cord-263157-8jin6oru	191	16	suppressed	suppress	VBD
cord-263157-8jin6oru	191	17	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	191	18	replication	replication	NN
cord-263157-8jin6oru	191	19	in	in	IN
cord-263157-8jin6oru	191	20	a	a	DT
cord-263157-8jin6oru	191	21	variant	variant	NN
cord-263157-8jin6oru	191	22	resistant	resistant	JJ
cord-263157-8jin6oru	191	23	to	to	IN
cord-263157-8jin6oru	191	24	a	a	DT
cord-263157-8jin6oru	191	25	shorter	short	JJR
cord-263157-8jin6oru	191	26	shRNA	shrna	NN
cord-263157-8jin6oru	191	27	for	for	IN
cord-263157-8jin6oru	191	28	the	the	DT
cord-263157-8jin6oru	191	29	same	same	JJ
cord-263157-8jin6oru	191	30	target	target	NN
cord-263157-8jin6oru	191	31	.	.	.
cord-263157-8jin6oru	192	1	Similarly	similarly	RB
cord-263157-8jin6oru	192	2	,	,	,
cord-263157-8jin6oru	192	3	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	192	4	vectors	vector	NNS
cord-263157-8jin6oru	192	5	expressing	express	VBG
cord-263157-8jin6oru	192	6	50	50	CD
cord-263157-8jin6oru	192	7	,	,	,
cord-263157-8jin6oru	192	8	53	53	CD
cord-263157-8jin6oru	192	9	,	,	,
cord-263157-8jin6oru	192	10	or	or	CC
cord-263157-8jin6oru	192	11	80	80	CD
cord-263157-8jin6oru	192	12	bp	bp	NNP
cord-263157-8jin6oru	192	13	lhRNAs	lhRNAs	NNP
cord-263157-8jin6oru	192	14	targeting	target	VBG
cord-263157-8jin6oru	192	15	contiguous	contiguous	JJ
cord-263157-8jin6oru	192	16	sequences	sequence	NNS
cord-263157-8jin6oru	192	17	within	within	IN
cord-263157-8jin6oru	192	18	the	the	DT
cord-263157-8jin6oru	192	19	Tat	Tat	NNP
cord-263157-8jin6oru	192	20	and	and	CC
cord-263157-8jin6oru	192	21	Rev	Rev	NNP
cord-263157-8jin6oru	192	22	genes	gene	NNS
cord-263157-8jin6oru	192	23	inhibited	inhibit	VBD
cord-263157-8jin6oru	192	24	viral	viral	JJ
cord-263157-8jin6oru	192	25	replication	replication	NN
cord-263157-8jin6oru	192	26	against	against	IN
cord-263157-8jin6oru	192	27	both	both	DT
cord-263157-8jin6oru	192	28	non	non	JJ
cord-263157-8jin6oru	192	29	-	-	JJ
cord-263157-8jin6oru	192	30	mutant	mutant	JJ
cord-263157-8jin6oru	192	31	and	and	CC
cord-263157-8jin6oru	192	32	mutant	mutant	JJ
cord-263157-8jin6oru	192	33	variants	variant	NNS
cord-263157-8jin6oru	192	34	of	of	IN
cord-263157-8jin6oru	192	35	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	192	36	(	(	-LRB-
cord-263157-8jin6oru	192	37	70	70	CD
cord-263157-8jin6oru	192	38	)	)	-RRB-
cord-263157-8jin6oru	192	39	.	.	.
cord-263157-8jin6oru	193	1	An	an	DT
cord-263157-8jin6oru	193	2	alternative	alternative	NN
cord-263157-8jin6oru	193	3	to	to	TO
cord-263157-8jin6oru	193	4	target	target	VB
cord-263157-8jin6oru	193	5	multiple	multiple	JJ
cord-263157-8jin6oru	193	6	conserved	conserve	VBN
cord-263157-8jin6oru	193	7	viral	viral	JJ
cord-263157-8jin6oru	193	8	genomic	genomic	JJ
cord-263157-8jin6oru	193	9	regions	region	NNS
cord-263157-8jin6oru	193	10	is	be	VBZ
cord-263157-8jin6oru	193	11	to	to	TO
cord-263157-8jin6oru	193	12	use	use	VB
cord-263157-8jin6oru	193	13	a	a	DT
cord-263157-8jin6oru	193	14	second	second	JJ
cord-263157-8jin6oru	193	15	generation	generation	NN
cord-263157-8jin6oru	193	16	of	of	IN
cord-263157-8jin6oru	193	17	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	193	18	that	that	WDT
cord-263157-8jin6oru	193	19	recognize	recognize	VBP
cord-263157-8jin6oru	193	20	the	the	DT
cord-263157-8jin6oru	193	21	mutated	mutated	JJ
cord-263157-8jin6oru	193	22	target	target	NN
cord-263157-8jin6oru	193	23	sites	site	NNS
cord-263157-8jin6oru	193	24	(	(	-LRB-
cord-263157-8jin6oru	193	25	60	60	CD
cord-263157-8jin6oru	193	26	,	,	,
cord-263157-8jin6oru	193	27	69	69	CD
cord-263157-8jin6oru	193	28	,	,	,
cord-263157-8jin6oru	193	29	71	71	CD
cord-263157-8jin6oru	193	30	)	)	-RRB-
cord-263157-8jin6oru	193	31	by	by	IN
cord-263157-8jin6oru	193	32	using	use	VBG
cord-263157-8jin6oru	193	33	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	193	34	or	or	CC
cord-263157-8jin6oru	193	35	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	193	36	that	that	WDT
cord-263157-8jin6oru	193	37	target	target	VBP
cord-263157-8jin6oru	193	38	the	the	DT
cord-263157-8jin6oru	193	39	most	most	RBS
cord-263157-8jin6oru	193	40	likely	likely	JJ
cord-263157-8jin6oru	193	41	escape	escape	NN
cord-263157-8jin6oru	193	42	variants	variant	NNS
cord-263157-8jin6oru	193	43	.	.	.
cord-263157-8jin6oru	194	1	Sabariegos	Sabariegos	NNP
cord-263157-8jin6oru	194	2	et	et	NNP
cord-263157-8jin6oru	194	3	al	al	NNP
cord-263157-8jin6oru	194	4	.	.	.
cord-263157-8jin6oru	195	1	tested	test	VBD
cord-263157-8jin6oru	195	2	a	a	DT
cord-263157-8jin6oru	195	3	second	second	JJ
cord-263157-8jin6oru	195	4	generation	generation	NN
cord-263157-8jin6oru	195	5	siRNA	siRNA	NNP
cord-263157-8jin6oru	195	6	that	that	WDT
cord-263157-8jin6oru	195	7	compensates	compensate	VBZ
cord-263157-8jin6oru	195	8	for	for	IN
cord-263157-8jin6oru	195	9	a	a	DT
cord-263157-8jin6oru	195	10	fully	fully	RB
cord-263157-8jin6oru	195	11	resistant	resistant	JJ
cord-263157-8jin6oru	195	12	mutation	mutation	NN
cord-263157-8jin6oru	195	13	at	at	IN
cord-263157-8jin6oru	195	14	position	position	NN
cord-263157-8jin6oru	195	15	9	9	CD
cord-263157-8jin6oru	195	16	of	of	IN
cord-263157-8jin6oru	195	17	the	the	DT
cord-263157-8jin6oru	195	18	target	target	NN
cord-263157-8jin6oru	195	19	sequence	sequence	NN
cord-263157-8jin6oru	195	20	(	(	-LRB-
cord-263157-8jin6oru	195	21	60	60	CD
cord-263157-8jin6oru	195	22	)	)	-RRB-
cord-263157-8jin6oru	195	23	.	.	.
cord-263157-8jin6oru	196	1	Nishitsuji	Nishitsuji	NNP
cord-263157-8jin6oru	196	2	et	et	NNP
cord-263157-8jin6oru	196	3	al	al	NNP
cord-263157-8jin6oru	196	4	.	.	.
cord-263157-8jin6oru	197	1	isolated	isolate	VBN
cord-263157-8jin6oru	197	2	single	single	JJ
cord-263157-8jin6oru	197	3	point	point	NN
cord-263157-8jin6oru	197	4	mutation	mutation	NN
cord-263157-8jin6oru	197	5	resistant	resistant	JJ
cord-263157-8jin6oru	197	6	viruses	virus	NNS
cord-263157-8jin6oru	197	7	that	that	WDT
cord-263157-8jin6oru	197	8	emerged	emerge	VBD
cord-263157-8jin6oru	197	9	in	in	IN
cord-263157-8jin6oru	197	10	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	197	11	vector	vector	NN
cord-263157-8jin6oru	197	12	transduced	transduce	VBN
cord-263157-8jin6oru	197	13	cells	cell	NNS
cord-263157-8jin6oru	197	14	expressing	express	VBG
cord-263157-8jin6oru	197	15	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	197	16	against	against	IN
cord-263157-8jin6oru	197	17	the	the	DT
cord-263157-8jin6oru	197	18	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	197	19	U3	U3	NNP
cord-263157-8jin6oru	197	20	region	region	NN
cord-263157-8jin6oru	197	21	,	,	,
cord-263157-8jin6oru	197	22	integrase	integrase	NN
cord-263157-8jin6oru	197	23	and	and	CC
cord-263157-8jin6oru	197	24	Tat	Tat	NNP
cord-263157-8jin6oru	197	25	genes	gene	NNS
cord-263157-8jin6oru	197	26	(	(	-LRB-
cord-263157-8jin6oru	197	27	69	69	CD
cord-263157-8jin6oru	197	28	)	)	-RRB-
cord-263157-8jin6oru	197	29	and	and	CC
cord-263157-8jin6oru	197	30	restored	restore	VBD
cord-263157-8jin6oru	197	31	viral	viral	JJ
cord-263157-8jin6oru	197	32	inhibition	inhibition	NN
cord-263157-8jin6oru	197	33	by	by	IN
cord-263157-8jin6oru	197	34	using	use	VBG
cord-263157-8jin6oru	197	35	a	a	DT
cord-263157-8jin6oru	197	36	second	second	JJ
cord-263157-8jin6oru	197	37	generation	generation	NN
cord-263157-8jin6oru	197	38	shRNA	shrna	NN
cord-263157-8jin6oru	197	39	that	that	WDT
cord-263157-8jin6oru	197	40	matched	match	VBD
cord-263157-8jin6oru	197	41	escape	escape	NN
cord-263157-8jin6oru	197	42	mutants	mutant	NNS
cord-263157-8jin6oru	197	43	(	(	-LRB-
cord-263157-8jin6oru	197	44	69	69	CD
cord-263157-8jin6oru	197	45	)	)	-RRB-
cord-263157-8jin6oru	197	46	.	.	.
cord-263157-8jin6oru	198	1	The	the	DT
cord-263157-8jin6oru	198	2	use	use	NN
cord-263157-8jin6oru	198	3	of	of	IN
cord-263157-8jin6oru	198	4	cell	cell	NN
cord-263157-8jin6oru	198	5	culture	culture	NN
cord-263157-8jin6oru	198	6	infections	infection	NNS
cord-263157-8jin6oru	198	7	to	to	TO
cord-263157-8jin6oru	198	8	determine	determine	VB
cord-263157-8jin6oru	198	9	which	which	WDT
cord-263157-8jin6oru	198	10	target	target	NN
cord-263157-8jin6oru	198	11	site	site	NN
cord-263157-8jin6oru	198	12	mutations	mutation	NNS
cord-263157-8jin6oru	198	13	result	result	VBP
cord-263157-8jin6oru	198	14	in	in	IN
cord-263157-8jin6oru	198	15	replication	replication	NN
cord-263157-8jin6oru	198	16	competent	competent	JJ
cord-263157-8jin6oru	198	17	escape	escape	NN
cord-263157-8jin6oru	198	18	variants	variant	NNS
cord-263157-8jin6oru	198	19	will	will	MD
cord-263157-8jin6oru	198	20	allow	allow	VB
cord-263157-8jin6oru	198	21	the	the	DT
cord-263157-8jin6oru	198	22	design	design	NN
cord-263157-8jin6oru	198	23	of	of	IN
cord-263157-8jin6oru	198	24	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	198	25	capable	capable	JJ
cord-263157-8jin6oru	198	26	of	of	IN
cord-263157-8jin6oru	198	27	inhibiting	inhibit	VBG
cord-263157-8jin6oru	198	28	these	these	DT
cord-263157-8jin6oru	198	29	escape	escape	NN
cord-263157-8jin6oru	198	30	variants	variant	NNS
cord-263157-8jin6oru	198	31	.	.	.
cord-263157-8jin6oru	199	1	To	to	TO
cord-263157-8jin6oru	199	2	reduce	reduce	VB
cord-263157-8jin6oru	199	3	the	the	DT
cord-263157-8jin6oru	199	4	number	number	NN
cord-263157-8jin6oru	199	5	of	of	IN
cord-263157-8jin6oru	199	6	second	second	JJ
cord-263157-8jin6oru	199	7	generation	generation	NN
cord-263157-8jin6oru	199	8	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	199	9	to	to	TO
cord-263157-8jin6oru	199	10	be	be	VB
cord-263157-8jin6oru	199	11	designed	design	VBN
cord-263157-8jin6oru	199	12	,	,	,
cord-263157-8jin6oru	199	13	this	this	DT
cord-263157-8jin6oru	199	14	strategy	strategy	NN
cord-263157-8jin6oru	199	15	should	should	MD
cord-263157-8jin6oru	199	16	also	also	RB
cord-263157-8jin6oru	199	17	target	target	VB
cord-263157-8jin6oru	199	18	a	a	DT
cord-263157-8jin6oru	199	19	conserved	conserved	JJ
cord-263157-8jin6oru	199	20	region	region	NN
cord-263157-8jin6oru	199	21	of	of	IN
cord-263157-8jin6oru	199	22	the	the	DT
cord-263157-8jin6oru	199	23	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	199	24	coding	code	VBG
cord-263157-8jin6oru	199	25	sequence	sequence	NN
cord-263157-8jin6oru	199	26	and	and	CC
cord-263157-8jin6oru	199	27	the	the	DT
cord-263157-8jin6oru	199	28	new	new	JJ
cord-263157-8jin6oru	199	29	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	199	30	should	should	MD
cord-263157-8jin6oru	199	31	also	also	RB
cord-263157-8jin6oru	199	32	be	be	VB
cord-263157-8jin6oru	199	33	capable	capable	JJ
cord-263157-8jin6oru	199	34	of	of	IN
cord-263157-8jin6oru	199	35	inducing	induce	VBG
cord-263157-8jin6oru	199	36	RNAi	RNAi	NNS
cord-263157-8jin6oru	199	37	.	.	.
cord-263157-8jin6oru	200	1	Recently	recently	RB
cord-263157-8jin6oru	200	2	,	,	,
cord-263157-8jin6oru	200	3	Escherichia	Escherichia	NNP
cord-263157-8jin6oru	200	4	coli	coli	VBZ
cord-263157-8jin6oru	200	5	endoribonuclease	endoribonuclease	NN
cord-263157-8jin6oru	200	6	III	III	NNP
cord-263157-8jin6oru	200	7	(	(	-LRB-
cord-263157-8jin6oru	200	8	RNase	RNase	NNP
cord-263157-8jin6oru	200	9	III	III	NNP
cord-263157-8jin6oru	200	10	)	)	-RRB-
cord-263157-8jin6oru	200	11	or	or	CC
cord-263157-8jin6oru	200	12	mammalian	mammalian	JJ
cord-263157-8jin6oru	200	13	Dicer	Dicer	NNP
cord-263157-8jin6oru	200	14	was	be	VBD
cord-263157-8jin6oru	200	15	used	use	VBN
cord-263157-8jin6oru	200	16	to	to	TO
cord-263157-8jin6oru	200	17	cleave	cleave	VB
cord-263157-8jin6oru	200	18	dsRNA	dsrna	NN
cord-263157-8jin6oru	200	19	into	into	IN
cord-263157-8jin6oru	200	20	endoribonuclease	endoribonuclease	NN
cord-263157-8jin6oru	200	21	-	-	HYPH
cord-263157-8jin6oru	200	22	prepared	prepare	VBN
cord-263157-8jin6oru	200	23	siRNA	siRNA	NNP
cord-263157-8jin6oru	200	24	(	(	-LRB-
cord-263157-8jin6oru	200	25	esiRNA	esiRNA	NNP
cord-263157-8jin6oru	200	26	)	)	-RRB-
cord-263157-8jin6oru	200	27	(	(	-LRB-
cord-263157-8jin6oru	200	28	72	72	CD
cord-263157-8jin6oru	200	29	)	)	-RRB-
cord-263157-8jin6oru	200	30	,	,	,
cord-263157-8jin6oru	200	31	which	which	WDT
cord-263157-8jin6oru	200	32	generate	generate	VBP
cord-263157-8jin6oru	200	33	a	a	DT
cord-263157-8jin6oru	200	34	variety	variety	NN
cord-263157-8jin6oru	200	35	of	of	IN
cord-263157-8jin6oru	200	36	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	200	37	that	that	WDT
cord-263157-8jin6oru	200	38	efficiently	efficiently	RB
cord-263157-8jin6oru	200	39	and	and	CC
cord-263157-8jin6oru	200	40	specifically	specifically	RB
cord-263157-8jin6oru	200	41	target	target	VB
cord-263157-8jin6oru	200	42	multiple	multiple	JJ
cord-263157-8jin6oru	200	43	sites	site	NNS
cord-263157-8jin6oru	200	44	in	in	IN
cord-263157-8jin6oru	200	45	the	the	DT
cord-263157-8jin6oru	200	46	cognate	cognate	JJ
cord-263157-8jin6oru	200	47	RNA	RNA	NNP
cord-263157-8jin6oru	200	48	(	(	-LRB-
cord-263157-8jin6oru	200	49	73	73	CD
cord-263157-8jin6oru	200	50	,	,	,
cord-263157-8jin6oru	200	51	74	74	CD
cord-263157-8jin6oru	200	52	)	)	-RRB-
cord-263157-8jin6oru	200	53	.	.	.
cord-263157-8jin6oru	201	1	In	in	IN
cord-263157-8jin6oru	201	2	this	this	DT
cord-263157-8jin6oru	201	3	study	study	NN
cord-263157-8jin6oru	201	4	,	,	,
cord-263157-8jin6oru	201	5	esiRNAs	esiRNAs	NNP
cord-263157-8jin6oru	201	6	targeting	target	VBG
cord-263157-8jin6oru	201	7	the	the	DT
cord-263157-8jin6oru	201	8	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	201	9	RT	RT	NNP
cord-263157-8jin6oru	201	10	coding	code	VBG
cord-263157-8jin6oru	201	11	region	region	NN
cord-263157-8jin6oru	201	12	reduced	reduce	VBN
cord-263157-8jin6oru	201	13	viral	viral	JJ
cord-263157-8jin6oru	201	14	replication	replication	NN
cord-263157-8jin6oru	201	15	by	by	IN
cord-263157-8jin6oru	201	16	90	90	CD
cord-263157-8jin6oru	201	17	%	%	NN
cord-263157-8jin6oru	201	18	in	in	IN
cord-263157-8jin6oru	201	19	a	a	DT
cord-263157-8jin6oru	201	20	dose	dose	NN
cord-263157-8jin6oru	201	21	dependent	dependent	JJ
cord-263157-8jin6oru	201	22	and	and	CC
cord-263157-8jin6oru	201	23	sequence	sequence	NN
cord-263157-8jin6oru	201	24	specific	specific	JJ
cord-263157-8jin6oru	201	25	manner	manner	NN
cord-263157-8jin6oru	201	26	.	.	.
cord-263157-8jin6oru	202	1	Importantly	importantly	RB
cord-263157-8jin6oru	202	2	,	,	,
cord-263157-8jin6oru	202	3	esiRNAs	esiRNAs	NNP
cord-263157-8jin6oru	202	4	obtained	obtain	VBD
cord-263157-8jin6oru	202	5	from	from	IN
cord-263157-8jin6oru	202	6	the	the	DT
cord-263157-8jin6oru	202	7	prototypic	prototypic	JJ
cord-263157-8jin6oru	202	8	RT	RT	NNP
cord-263157-8jin6oru	202	9	sequence	sequence	NN
cord-263157-8jin6oru	202	10	of	of	IN
cord-263157-8jin6oru	202	11	the	the	DT
cord-263157-8jin6oru	202	12	HXB2	HXB2	NNP
cord-263157-8jin6oru	202	13	strain	strain	NN
cord-263157-8jin6oru	202	14	and	and	CC
cord-263157-8jin6oru	202	15	from	from	IN
cord-263157-8jin6oru	202	16	highly	highly	RB
cord-263157-8jin6oru	202	17	mutated	mutate	VBN
cord-263157-8jin6oru	202	18	RT	rt	NN
cord-263157-8jin6oru	202	19	sequences	sequence	NNS
cord-263157-8jin6oru	202	20	showed	show	VBD
cord-263157-8jin6oru	202	21	similar	similar	JJ
cord-263157-8jin6oru	202	22	degrees	degree	NNS
cord-263157-8jin6oru	202	23	of	of	IN
cord-263157-8jin6oru	202	24	viral	viral	JJ
cord-263157-8jin6oru	202	25	inhibition	inhibition	NN
cord-263157-8jin6oru	202	26	,	,	,
cord-263157-8jin6oru	202	27	suggesting	suggest	VBG
cord-263157-8jin6oru	202	28	that	that	IN
cord-263157-8jin6oru	202	29	the	the	DT
cord-263157-8jin6oru	202	30	heterogeneous	heterogeneous	JJ
cord-263157-8jin6oru	202	31	population	population	NN
cord-263157-8jin6oru	202	32	of	of	IN
cord-263157-8jin6oru	202	33	esiRNAs	esiRNAs	NNP
cord-263157-8jin6oru	202	34	could	could	MD
cord-263157-8jin6oru	202	35	overcome	overcome	VB
cord-263157-8jin6oru	202	36	individual	individual	JJ
cord-263157-8jin6oru	202	37	mismatches	mismatch	NNS
cord-263157-8jin6oru	202	38	in	in	IN
cord-263157-8jin6oru	202	39	the	the	DT
cord-263157-8jin6oru	202	40	RT	RT	NNP
cord-263157-8jin6oru	202	41	sequence	sequence	NN
cord-263157-8jin6oru	202	42	.	.	.
cord-263157-8jin6oru	203	1	These	these	DT
cord-263157-8jin6oru	203	2	results	result	NNS
cord-263157-8jin6oru	203	3	demonstrated	demonstrate	VBD
cord-263157-8jin6oru	203	4	the	the	DT
cord-263157-8jin6oru	203	5	ability	ability	NN
cord-263157-8jin6oru	203	6	of	of	IN
cord-263157-8jin6oru	203	7	esiRNAs	esiRNAs	NNPS
cord-263157-8jin6oru	203	8	to	to	TO
cord-263157-8jin6oru	203	9	function	function	VB
cord-263157-8jin6oru	203	10	as	as	IN
cord-263157-8jin6oru	203	11	potent	potent	JJ
cord-263157-8jin6oru	203	12	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	203	13	inhibitors	inhibitor	NNS
cord-263157-8jin6oru	203	14	.	.	.
cord-263157-8jin6oru	204	1	Moreover	moreover	RB
cord-263157-8jin6oru	204	2	,	,	,
cord-263157-8jin6oru	204	3	sequence	sequence	NN
cord-263157-8jin6oru	204	4	targets	target	NNS
cord-263157-8jin6oru	204	5	do	do	VBP
cord-263157-8jin6oru	204	6	not	not	RB
cord-263157-8jin6oru	204	7	need	need	VB
cord-263157-8jin6oru	204	8	to	to	TO
cord-263157-8jin6oru	204	9	be	be	VB
cord-263157-8jin6oru	204	10	highly	highly	RB
cord-263157-8jin6oru	204	11	conserved	conserve	VBN
cord-263157-8jin6oru	204	12	to	to	TO
cord-263157-8jin6oru	204	13	reach	reach	VB
cord-263157-8jin6oru	204	14	a	a	DT
cord-263157-8jin6oru	204	15	high	high	JJ
cord-263157-8jin6oru	204	16	level	level	NN
cord-263157-8jin6oru	204	17	of	of	IN
cord-263157-8jin6oru	204	18	viral	viral	JJ
cord-263157-8jin6oru	204	19	replication	replication	NN
cord-263157-8jin6oru	204	20	inhibition	inhibition	NN
cord-263157-8jin6oru	204	21	.	.	.
cord-263157-8jin6oru	205	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	205	2	,	,	,
cord-263157-8jin6oru	205	3	this	this	DT
cord-263157-8jin6oru	205	4	work	work	NN
cord-263157-8jin6oru	205	5	was	be	VBD
cord-263157-8jin6oru	205	6	performed	perform	VBN
cord-263157-8jin6oru	205	7	in	in	IN
cord-263157-8jin6oru	205	8	cell	cell	NN
cord-263157-8jin6oru	205	9	culture	culture	NN
cord-263157-8jin6oru	205	10	and	and	CC
cord-263157-8jin6oru	205	11	its	-PRON-	PRP$
cord-263157-8jin6oru	205	12	translation	translation	NN
cord-263157-8jin6oru	205	13	to	to	IN
cord-263157-8jin6oru	205	14	an	an	DT
cord-263157-8jin6oru	205	15	in	in	IN
cord-263157-8jin6oru	205	16	vivo	vivo	NN
cord-263157-8jin6oru	205	17	setting	setting	NN
cord-263157-8jin6oru	205	18	may	may	MD
cord-263157-8jin6oru	205	19	be	be	VB
cord-263157-8jin6oru	205	20	difficult	difficult	JJ
cord-263157-8jin6oru	205	21	.	.	.
cord-263157-8jin6oru	206	1	Another	another	DT
cord-263157-8jin6oru	206	2	recently	recently	RB
cord-263157-8jin6oru	206	3	explored	explore	VBN
cord-263157-8jin6oru	206	4	strategy	strategy	NN
cord-263157-8jin6oru	206	5	has	have	VBZ
cord-263157-8jin6oru	206	6	been	be	VBN
cord-263157-8jin6oru	206	7	to	to	TO
cord-263157-8jin6oru	206	8	combine	combine	VB
cord-263157-8jin6oru	206	9	an	an	DT
cord-263157-8jin6oru	206	10	shRNA	shrna	NN
cord-263157-8jin6oru	206	11	with	with	IN
cord-263157-8jin6oru	206	12	an	an	DT
cord-263157-8jin6oru	206	13	anti	anti	JJ
cord-263157-8jin6oru	206	14	-	-	NNP
cord-263157-8jin6oru	206	15	HIV-1	hiv-1	JJ
cord-263157-8jin6oru	206	16	ribozyme	ribozyme	NNS
cord-263157-8jin6oru	206	17	and	and	CC
cord-263157-8jin6oru	206	18	an	an	DT
cord-263157-8jin6oru	206	19	RNA	RNA	NNP
cord-263157-8jin6oru	206	20	decoy	decoy	NN
cord-263157-8jin6oru	206	21	.	.	.
cord-263157-8jin6oru	207	1	A	a	DT
cord-263157-8jin6oru	207	2	triple	triple	JJ
cord-263157-8jin6oru	207	3	combination	combination	NN
cord-263157-8jin6oru	207	4	lentiviral	lentiviral	NN
cord-263157-8jin6oru	207	5	construct	construct	VB
cord-263157-8jin6oru	207	6	comprised	comprise	VBN
cord-263157-8jin6oru	207	7	of	of	IN
cord-263157-8jin6oru	207	8	a	a	DT
cord-263157-8jin6oru	207	9	U6-driven	U6-driven	NNP
cord-263157-8jin6oru	207	10	TAR	TAR	NNP
cord-263157-8jin6oru	207	11	RNA	rna	NN
cord-263157-8jin6oru	207	12	decoy	decoy	NN
cord-263157-8jin6oru	207	13	with	with	IN
cord-263157-8jin6oru	207	14	a	a	DT
cord-263157-8jin6oru	207	15	U16	U16	NNP
cord-263157-8jin6oru	207	16	snoRNA	snoRNA	NNP
cord-263157-8jin6oru	207	17	for	for	IN
cord-263157-8jin6oru	207	18	nucleolar	nucleolar	JJ
cord-263157-8jin6oru	207	19	localization	localization	NN
cord-263157-8jin6oru	207	20	,	,	,
cord-263157-8jin6oru	207	21	a	a	DT
cord-263157-8jin6oru	207	22	U6	U6	NNP
cord-263157-8jin6oru	207	23	promoted	promote	VBD
cord-263157-8jin6oru	207	24	shRNA	shrna	NN
cord-263157-8jin6oru	207	25	targeted	target	VBN
cord-263157-8jin6oru	207	26	to	to	IN
cord-263157-8jin6oru	207	27	both	both	CC
cord-263157-8jin6oru	207	28	Tat	Tat	NNP
cord-263157-8jin6oru	207	29	and	and	CC
cord-263157-8jin6oru	207	30	Rev	Rev	NNP
cord-263157-8jin6oru	207	31	,	,	,
cord-263157-8jin6oru	207	32	and	and	CC
cord-263157-8jin6oru	207	33	a	a	DT
cord-263157-8jin6oru	207	34	VA1	VA1	NNP
cord-263157-8jin6oru	207	35	promoted	promote	VBD
cord-263157-8jin6oru	207	36	chimeric	chimeric	JJ
cord-263157-8jin6oru	207	37	anti	anti	JJ
cord-263157-8jin6oru	207	38	-	-	JJ
cord-263157-8jin6oru	207	39	CCR5	ccr5	JJ
cord-263157-8jin6oru	207	40	trans	trans	JJ
cord-263157-8jin6oru	207	41	-	-	JJ
cord-263157-8jin6oru	207	42	cleaving	cleave	VBG
cord-263157-8jin6oru	207	43	hammerhead	hammerhead	NN
cord-263157-8jin6oru	207	44	ribozyme	ribozyme	NNP
cord-263157-8jin6oru	207	45	efficiently	efficiently	RB
cord-263157-8jin6oru	207	46	transduced	transduce	VBN
cord-263157-8jin6oru	207	47	human	human	JJ
cord-263157-8jin6oru	207	48	progenitor	progenitor	NN
cord-263157-8jin6oru	207	49	CD34	CD34	NNP
cord-263157-8jin6oru	207	50	+	+	CC
cord-263157-8jin6oru	207	51	cells	cell	NNS
cord-263157-8jin6oru	207	52	and	and	CC
cord-263157-8jin6oru	207	53	improved	improved	JJ
cord-263157-8jin6oru	207	54	suppression	suppression	NN
cord-263157-8jin6oru	207	55	of	of	IN
cord-263157-8jin6oru	207	56	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	207	57	over	over	IN
cord-263157-8jin6oru	207	58	42	42	CD
cord-263157-8jin6oru	207	59	days	day	NNS
cord-263157-8jin6oru	207	60	compared	compare	VBN
cord-263157-8jin6oru	207	61	to	to	IN
cord-263157-8jin6oru	207	62	a	a	DT
cord-263157-8jin6oru	207	63	single	single	JJ
cord-263157-8jin6oru	207	64	anti	anti	JJ
cord-263157-8jin6oru	207	65	-	-	JJ
cord-263157-8jin6oru	207	66	Tat	Tat	NNP
cord-263157-8jin6oru	207	67	/	/	SYM
cord-263157-8jin6oru	207	68	Rev	Rev	NNP
cord-263157-8jin6oru	207	69	shRNA	shrna	NN
cord-263157-8jin6oru	207	70	or	or	CC
cord-263157-8jin6oru	207	71	double	double	JJ
cord-263157-8jin6oru	207	72	combinations	combination	NNS
cord-263157-8jin6oru	207	73	of	of	IN
cord-263157-8jin6oru	207	74	shRNA/	shRNA/	NNP
cord-263157-8jin6oru	207	75	ribozyme	ribozyme	NNS
cord-263157-8jin6oru	207	76	or	or	CC
cord-263157-8jin6oru	207	77	decoy	decoy	NN
cord-263157-8jin6oru	207	78	(	(	-LRB-
cord-263157-8jin6oru	207	79	75	75	CD
cord-263157-8jin6oru	207	80	)	)	-RRB-
cord-263157-8jin6oru	207	81	.	.	.
cord-263157-8jin6oru	208	1	This	this	DT
cord-263157-8jin6oru	208	2	triple	triple	JJ
cord-263157-8jin6oru	208	3	combination	combination	NN
cord-263157-8jin6oru	208	4	is	be	VBZ
cord-263157-8jin6oru	208	5	about	about	JJ
cord-263157-8jin6oru	208	6	to	to	TO
cord-263157-8jin6oru	208	7	enter	enter	VB
cord-263157-8jin6oru	208	8	human	human	JJ
cord-263157-8jin6oru	208	9	clinical	clinical	JJ
cord-263157-8jin6oru	208	10	trials	trial	NNS
cord-263157-8jin6oru	208	11	for	for	IN
cord-263157-8jin6oru	208	12	AIDS	AIDS	NNP
cord-263157-8jin6oru	208	13	/	/	SYM
cord-263157-8jin6oru	208	14	lymphoma	lymphoma	NN
cord-263157-8jin6oru	208	15	patients	patient	NNS
cord-263157-8jin6oru	208	16	using	use	VBG
cord-263157-8jin6oru	208	17	autologous	autologous	JJ
cord-263157-8jin6oru	208	18	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	208	19	progenitor	progenitor	NN
cord-263157-8jin6oru	208	20	cells	cell	NNS
cord-263157-8jin6oru	208	21	as	as	IN
cord-263157-8jin6oru	208	22	the	the	DT
cord-263157-8jin6oru	208	23	targets	target	NNS
cord-263157-8jin6oru	208	24	for	for	IN
cord-263157-8jin6oru	208	25	vector	vector	NN
cord-263157-8jin6oru	208	26	insertion	insertion	NN
cord-263157-8jin6oru	208	27	.	.	.
cord-263157-8jin6oru	209	1	A	a	DT
cord-263157-8jin6oru	209	2	second	second	JJ
cord-263157-8jin6oru	209	3	trial	trial	NN
cord-263157-8jin6oru	209	4	in	in	IN
cord-263157-8jin6oru	209	5	which	which	WDT
cord-263157-8jin6oru	209	6	the	the	DT
cord-263157-8jin6oru	209	7	same	same	JJ
cord-263157-8jin6oru	209	8	construct	construct	NN
cord-263157-8jin6oru	209	9	will	will	MD
cord-263157-8jin6oru	209	10	be	be	VB
cord-263157-8jin6oru	209	11	inserted	insert	VBN
cord-263157-8jin6oru	209	12	in	in	IN
cord-263157-8jin6oru	209	13	autologous	autologous	JJ
cord-263157-8jin6oru	209	14	T	t	NN
cord-263157-8jin6oru	209	15	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	209	16	will	will	MD
cord-263157-8jin6oru	209	17	most	most	RBS
cord-263157-8jin6oru	209	18	likely	likely	RB
cord-263157-8jin6oru	209	19	initiate	initiate	VB
cord-263157-8jin6oru	209	20	in	in	IN
cord-263157-8jin6oru	209	21	late	late	JJ
cord-263157-8jin6oru	209	22	2007	2007	CD
cord-263157-8jin6oru	209	23	or	or	CC
cord-263157-8jin6oru	209	24	early	early	JJ
cord-263157-8jin6oru	209	25	2008	2008	CD
cord-263157-8jin6oru	209	26	(	(	-LRB-
cord-263157-8jin6oru	209	27	66	66	CD
cord-263157-8jin6oru	209	28	)	)	-RRB-
cord-263157-8jin6oru	209	29	.	.	.
cord-263157-8jin6oru	210	1	In	in	IN
cord-263157-8jin6oru	210	2	order	order	NN
cord-263157-8jin6oru	210	3	to	to	TO
cord-263157-8jin6oru	210	4	prevent	prevent	VB
cord-263157-8jin6oru	210	5	provirus	provirus	NNP
cord-263157-8jin6oru	210	6	establishment	establishment	NN
cord-263157-8jin6oru	210	7	and	and	CC
cord-263157-8jin6oru	210	8	to	to	TO
cord-263157-8jin6oru	210	9	augment	augment	VB
cord-263157-8jin6oru	210	10	the	the	DT
cord-263157-8jin6oru	210	11	genetic	genetic	JJ
cord-263157-8jin6oru	210	12	barrier	barrier	NN
cord-263157-8jin6oru	210	13	for	for	IN
cord-263157-8jin6oru	210	14	viral	viral	JJ
cord-263157-8jin6oru	210	15	escape	escape	NN
cord-263157-8jin6oru	210	16	,	,	,
cord-263157-8jin6oru	210	17	cellular	cellular	JJ
cord-263157-8jin6oru	210	18	receptors	receptor	NNS
cord-263157-8jin6oru	210	19	or	or	CC
cord-263157-8jin6oru	210	20	co	co	NNS
cord-263157-8jin6oru	210	21	-	-	NNS
cord-263157-8jin6oru	210	22	factors	factor	NNS
cord-263157-8jin6oru	210	23	involved	involve	VBN
cord-263157-8jin6oru	210	24	in	in	IN
cord-263157-8jin6oru	210	25	the	the	DT
cord-263157-8jin6oru	210	26	initial	initial	JJ
cord-263157-8jin6oru	210	27	phase	phase	NN
cord-263157-8jin6oru	210	28	of	of	IN
cord-263157-8jin6oru	210	29	infection	infection	NN
cord-263157-8jin6oru	210	30	may	may	MD
cord-263157-8jin6oru	210	31	be	be	VB
cord-263157-8jin6oru	210	32	targeted	target	VBN
cord-263157-8jin6oru	210	33	.	.	.
cord-263157-8jin6oru	211	1	The	the	DT
cord-263157-8jin6oru	211	2	combination	combination	NN
cord-263157-8jin6oru	211	3	of	of	IN
cord-263157-8jin6oru	211	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	211	5	or	or	CC
cord-263157-8jin6oru	211	6	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	211	7	directed	direct	VBD
cord-263157-8jin6oru	211	8	against	against	IN
cord-263157-8jin6oru	211	9	both	both	DT
cord-263157-8jin6oru	211	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	211	11	and	and	CC
cord-263157-8jin6oru	211	12	cellular	cellular	JJ
cord-263157-8jin6oru	211	13	transcripts	transcript	NNS
cord-263157-8jin6oru	211	14	may	may	MD
cord-263157-8jin6oru	211	15	result	result	VB
cord-263157-8jin6oru	211	16	in	in	IN
cord-263157-8jin6oru	211	17	a	a	DT
cord-263157-8jin6oru	211	18	more	more	RBR
cord-263157-8jin6oru	211	19	potent	potent	JJ
cord-263157-8jin6oru	211	20	and	and	CC
cord-263157-8jin6oru	211	21	robust	robust	JJ
cord-263157-8jin6oru	211	22	inhibition	inhibition	NN
cord-263157-8jin6oru	211	23	of	of	IN
cord-263157-8jin6oru	211	24	viral	viral	JJ
cord-263157-8jin6oru	211	25	replication	replication	NN
cord-263157-8jin6oru	211	26	.	.	.
cord-263157-8jin6oru	212	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	212	2	,	,	,
cord-263157-8jin6oru	212	3	targeting	target	VBG
cord-263157-8jin6oru	212	4	a	a	DT
cord-263157-8jin6oru	212	5	cellular	cellular	JJ
cord-263157-8jin6oru	212	6	cofactor	cofactor	NN
cord-263157-8jin6oru	212	7	required	require	VBN
cord-263157-8jin6oru	212	8	by	by	IN
cord-263157-8jin6oru	212	9	the	the	DT
cord-263157-8jin6oru	212	10	virus	virus	NN
cord-263157-8jin6oru	212	11	should	should	MD
cord-263157-8jin6oru	212	12	be	be	VB
cord-263157-8jin6oru	212	13	performed	perform	VBN
cord-263157-8jin6oru	212	14	with	with	IN
cord-263157-8jin6oru	212	15	caution	caution	NN
cord-263157-8jin6oru	212	16	as	as	IN
cord-263157-8jin6oru	212	17	this	this	DT
cord-263157-8jin6oru	212	18	approach	approach	NN
cord-263157-8jin6oru	212	19	has	have	VBZ
cord-263157-8jin6oru	212	20	the	the	DT
cord-263157-8jin6oru	212	21	potential	potential	NN
cord-263157-8jin6oru	212	22	to	to	TO
cord-263157-8jin6oru	212	23	harm	harm	VB
cord-263157-8jin6oru	212	24	host	host	NN
cord-263157-8jin6oru	212	25	cells	cell	NNS
cord-263157-8jin6oru	212	26	.	.	.
cord-263157-8jin6oru	213	1	Several	several	JJ
cord-263157-8jin6oru	213	2	cellular	cellular	JJ
cord-263157-8jin6oru	213	3	factors	factor	NNS
cord-263157-8jin6oru	213	4	involved	involve	VBN
cord-263157-8jin6oru	213	5	in	in	IN
cord-263157-8jin6oru	213	6	the	the	DT
cord-263157-8jin6oru	213	7	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	213	8	life	life	NN
cord-263157-8jin6oru	213	9	-	-	HYPH
cord-263157-8jin6oru	213	10	cycle	cycle	NN
cord-263157-8jin6oru	213	11	have	have	VBP
cord-263157-8jin6oru	213	12	been	be	VBN
cord-263157-8jin6oru	213	13	explored	explore	VBN
cord-263157-8jin6oru	213	14	as	as	IN
cord-263157-8jin6oru	213	15	possible	possible	JJ
cord-263157-8jin6oru	213	16	RNAi	RNAi	NNP
cord-263157-8jin6oru	213	17	targets	target	NNS
cord-263157-8jin6oru	213	18	:	:	:
cord-263157-8jin6oru	213	19	the	the	DT
cord-263157-8jin6oru	213	20	CD4	CD4	NNP
cord-263157-8jin6oru	213	21	receptor	receptor	NN
cord-263157-8jin6oru	213	22	and	and	CC
cord-263157-8jin6oru	213	23	coreceptors	coreceptors	NNPS
cord-263157-8jin6oru	213	24	CCR5	CCR5	NNP
cord-263157-8jin6oru	213	25	and	and	CC
cord-263157-8jin6oru	213	26	CXCR4	CXCR4	NNP
cord-263157-8jin6oru	213	27	(	(	-LRB-
cord-263157-8jin6oru	213	28	17	17	CD
cord-263157-8jin6oru	213	29	,	,	,
cord-263157-8jin6oru	213	30	76	76	CD
cord-263157-8jin6oru	213	31	,	,	,
cord-263157-8jin6oru	213	32	77	77	CD
cord-263157-8jin6oru	213	33	)	)	-RRB-
cord-263157-8jin6oru	213	34	,	,	,
cord-263157-8jin6oru	213	35	integration	integration	NN
cord-263157-8jin6oru	213	36	factors	factor	NNS
cord-263157-8jin6oru	213	37	like	like	IN
cord-263157-8jin6oru	213	38	BAF-1	BAF-1	NNP
cord-263157-8jin6oru	213	39	,	,	,
cord-263157-8jin6oru	213	40	Emerin	Emerin	NNP
cord-263157-8jin6oru	213	41	and	and	CC
cord-263157-8jin6oru	213	42	LEDGF/75	LEDGF/75	NNP
cord-263157-8jin6oru	213	43	(	(	-LRB-
cord-263157-8jin6oru	213	44	78	78	CD
cord-263157-8jin6oru	213	45	,	,	,
cord-263157-8jin6oru	213	46	79	79	CD
cord-263157-8jin6oru	213	47	,	,	,
cord-263157-8jin6oru	213	48	80	80	CD
cord-263157-8jin6oru	213	49	)	)	-RRB-
cord-263157-8jin6oru	213	50	,	,	,
cord-263157-8jin6oru	213	51	transcriptional	transcriptional	JJ
cord-263157-8jin6oru	213	52	factors	factor	NNS
cord-263157-8jin6oru	213	53	such	such	JJ
cord-263157-8jin6oru	213	54	as	as	IN
cord-263157-8jin6oru	213	55	NF	nf	NN
cord-263157-8jin6oru	213	56	-	-	HYPH
cord-263157-8jin6oru	213	57	κ	κ	NN
cord-263157-8jin6oru	213	58	B	b	NN
cord-263157-8jin6oru	213	59	,	,	,
cord-263157-8jin6oru	213	60	PAK-1	PAK-1	NNP
cord-263157-8jin6oru	213	61	and	and	CC
cord-263157-8jin6oru	213	62	cyclin	cyclin	NN
cord-263157-8jin6oru	213	63	(	(	-LRB-
cord-263157-8jin6oru	213	64	22	22	CD
cord-263157-8jin6oru	213	65	,	,	,
cord-263157-8jin6oru	213	66	81	81	CD
cord-263157-8jin6oru	213	67	,	,	,
cord-263157-8jin6oru	213	68	82	82	CD
cord-263157-8jin6oru	213	69	)	)	-RRB-
cord-263157-8jin6oru	213	70	,	,	,
cord-263157-8jin6oru	213	71	and	and	CC
cord-263157-8jin6oru	213	72	Furin	furin	NN
cord-263157-8jin6oru	213	73	which	which	WDT
cord-263157-8jin6oru	213	74	is	be	VBZ
cord-263157-8jin6oru	213	75	involved	involve	VBN
cord-263157-8jin6oru	213	76	in	in	IN
cord-263157-8jin6oru	213	77	Env	Env	NNP
cord-263157-8jin6oru	213	78	maturation	maturation	NN
cord-263157-8jin6oru	213	79	(	(	-LRB-
cord-263157-8jin6oru	213	80	81	81	CD
cord-263157-8jin6oru	213	81	)	)	-RRB-
cord-263157-8jin6oru	213	82	.	.	.
cord-263157-8jin6oru	214	1	Since	since	IN
cord-263157-8jin6oru	214	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	214	3	actively	actively	RB
cord-263157-8jin6oru	214	4	suppressed	suppress	VBD
cord-263157-8jin6oru	214	5	the	the	DT
cord-263157-8jin6oru	214	6	expression	expression	NN
cord-263157-8jin6oru	214	7	of	of	IN
cord-263157-8jin6oru	214	8	the	the	DT
cord-263157-8jin6oru	214	9	polycistronic	polycistronic	NNP
cord-263157-8jin6oru	214	10	miRNA	miRNA	NNP
cord-263157-8jin6oru	214	11	cluster	cluster	NN
cord-263157-8jin6oru	214	12	miR-17/92	miR-17/92	NNP
cord-263157-8jin6oru	214	13	and	and	CC
cord-263157-8jin6oru	214	14	this	this	DT
cord-263157-8jin6oru	214	15	suppression	suppression	NN
cord-263157-8jin6oru	214	16	was	be	VBD
cord-263157-8jin6oru	214	17	found	find	VBN
cord-263157-8jin6oru	214	18	to	to	TO
cord-263157-8jin6oru	214	19	be	be	VB
cord-263157-8jin6oru	214	20	required	require	VBN
cord-263157-8jin6oru	214	21	for	for	IN
cord-263157-8jin6oru	214	22	efficient	efficient	JJ
cord-263157-8jin6oru	214	23	viral	viral	JJ
cord-263157-8jin6oru	214	24	replication	replication	NN
cord-263157-8jin6oru	214	25	(	(	-LRB-
cord-263157-8jin6oru	214	26	47	47	CD
cord-263157-8jin6oru	214	27	)	)	-RRB-
cord-263157-8jin6oru	214	28	,	,	,
cord-263157-8jin6oru	214	29	nuclear	nuclear	JJ
cord-263157-8jin6oru	214	30	expression	expression	NN
cord-263157-8jin6oru	214	31	of	of	IN
cord-263157-8jin6oru	214	32	some	some	DT
cord-263157-8jin6oru	214	33	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	214	34	from	from	IN
cord-263157-8jin6oru	214	35	this	this	DT
cord-263157-8jin6oru	214	36	cluster	cluster	NN
cord-263157-8jin6oru	214	37	may	may	MD
cord-263157-8jin6oru	214	38	be	be	VB
cord-263157-8jin6oru	214	39	another	another	DT
cord-263157-8jin6oru	214	40	alternative	alternative	NN
cord-263157-8jin6oru	214	41	to	to	TO
cord-263157-8jin6oru	214	42	inhibit	inhibit	VB
cord-263157-8jin6oru	214	43	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	214	44	replication	replication	NN
cord-263157-8jin6oru	214	45	(	(	-LRB-
cord-263157-8jin6oru	214	46	66	66	CD
cord-263157-8jin6oru	214	47	)	)	-RRB-
cord-263157-8jin6oru	214	48	.	.	.
cord-263157-8jin6oru	215	1	In	in	IN
cord-263157-8jin6oru	215	2	vivo	vivo	NN
cord-263157-8jin6oru	215	3	suppression	suppression	NN
cord-263157-8jin6oru	215	4	of	of	IN
cord-263157-8jin6oru	215	5	genes	gene	NNS
cord-263157-8jin6oru	215	6	such	such	JJ
cord-263157-8jin6oru	215	7	as	as	IN
cord-263157-8jin6oru	215	8	CD4	CD4	NNP
cord-263157-8jin6oru	215	9	could	could	MD
cord-263157-8jin6oru	215	10	be	be	VB
cord-263157-8jin6oru	215	11	limited	limit	VBN
cord-263157-8jin6oru	215	12	due	due	IN
cord-263157-8jin6oru	215	13	to	to	IN
cord-263157-8jin6oru	215	14	roles	role	NNS
cord-263157-8jin6oru	215	15	in	in	IN
cord-263157-8jin6oru	215	16	normal	normal	JJ
cord-263157-8jin6oru	215	17	immune	immune	JJ
cord-263157-8jin6oru	215	18	function	function	NN
cord-263157-8jin6oru	215	19	,	,	,
cord-263157-8jin6oru	215	20	making	make	VBG
cord-263157-8jin6oru	215	21	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	215	22	coreceptors	coreceptor	NNS
cord-263157-8jin6oru	215	23	more	more	RBR
cord-263157-8jin6oru	215	24	attractive	attractive	JJ
cord-263157-8jin6oru	215	25	alternatives	alternative	NNS
cord-263157-8jin6oru	215	26	to	to	TO
cord-263157-8jin6oru	215	27	target	target	VB
cord-263157-8jin6oru	215	28	host	host	NN
cord-263157-8jin6oru	215	29	proteins	protein	NNS
cord-263157-8jin6oru	215	30	.	.	.
cord-263157-8jin6oru	216	1	CCR5	CCR5	NNP
cord-263157-8jin6oru	216	2	may	may	MD
cord-263157-8jin6oru	216	3	be	be	VB
cord-263157-8jin6oru	216	4	a	a	DT
cord-263157-8jin6oru	216	5	potential	potential	JJ
cord-263157-8jin6oru	216	6	coreceptor	coreceptor	NN
cord-263157-8jin6oru	216	7	target	target	NN
cord-263157-8jin6oru	216	8	,	,	,
cord-263157-8jin6oru	216	9	as	as	IN
cord-263157-8jin6oru	216	10	a	a	DT
cord-263157-8jin6oru	216	11	homozygous	homozygous	JJ
cord-263157-8jin6oru	216	12	mutation	mutation	NN
cord-263157-8jin6oru	216	13	in	in	IN
cord-263157-8jin6oru	216	14	CCR5	CCR5	NNP
cord-263157-8jin6oru	216	15	effectively	effectively	RB
cord-263157-8jin6oru	216	16	conferred	confer	VBD
cord-263157-8jin6oru	216	17	protection	protection	NN
cord-263157-8jin6oru	216	18	from	from	IN
cord-263157-8jin6oru	216	19	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	216	20	without	without	IN
cord-263157-8jin6oru	216	21	any	any	DT
cord-263157-8jin6oru	216	22	serious	serious	JJ
cord-263157-8jin6oru	216	23	deleterious	deleterious	JJ
cord-263157-8jin6oru	216	24	effects	effect	NNS
cord-263157-8jin6oru	216	25	in	in	IN
cord-263157-8jin6oru	216	26	human	human	JJ
cord-263157-8jin6oru	216	27	immune	immune	JJ
cord-263157-8jin6oru	216	28	function	function	NN
cord-263157-8jin6oru	216	29	,	,	,
cord-263157-8jin6oru	216	30	and	and	CC
cord-263157-8jin6oru	216	31	heterozygous	heterozygous	JJ
cord-263157-8jin6oru	216	32	individuals	individual	NNS
cord-263157-8jin6oru	216	33	with	with	IN
cord-263157-8jin6oru	216	34	50	50	CD
cord-263157-8jin6oru	216	35	%	%	NN
cord-263157-8jin6oru	216	36	decrease	decrease	NN
cord-263157-8jin6oru	216	37	in	in	IN
cord-263157-8jin6oru	216	38	CCR5	CCR5	NNP
cord-263157-8jin6oru	216	39	surface	surface	NN
cord-263157-8jin6oru	216	40	expression	expression	NN
cord-263157-8jin6oru	216	41	have	have	VBP
cord-263157-8jin6oru	216	42	lower	low	JJR
cord-263157-8jin6oru	216	43	plasma	plasma	NN
cord-263157-8jin6oru	216	44	viral	viral	JJ
cord-263157-8jin6oru	216	45	load	load	NN
cord-263157-8jin6oru	216	46	and	and	CC
cord-263157-8jin6oru	216	47	a	a	DT
cord-263157-8jin6oru	216	48	substantially	substantially	RB
cord-263157-8jin6oru	216	49	prolonged	prolong	VBN
cord-263157-8jin6oru	216	50	course	course	NN
cord-263157-8jin6oru	216	51	of	of	IN
cord-263157-8jin6oru	216	52	disease	disease	NN
cord-263157-8jin6oru	216	53	(	(	-LRB-
cord-263157-8jin6oru	216	54	83	83	CD
cord-263157-8jin6oru	216	55	)	)	-RRB-
cord-263157-8jin6oru	216	56	.	.	.
cord-263157-8jin6oru	217	1	A	a	DT
cord-263157-8jin6oru	217	2	potent	potent	JJ
cord-263157-8jin6oru	217	3	and	and	CC
cord-263157-8jin6oru	217	4	noncytotoxic	noncytotoxic	NNP
cord-263157-8jin6oru	217	5	shRNA	shRNA	NNP
cord-263157-8jin6oru	217	6	directed	direct	VBN
cord-263157-8jin6oru	217	7	to	to	IN
cord-263157-8jin6oru	217	8	CCR5	CCR5	NNP
cord-263157-8jin6oru	217	9	stably	stably	RB
cord-263157-8jin6oru	217	10	down	down	RB
cord-263157-8jin6oru	217	11	-	-	HYPH
cord-263157-8jin6oru	217	12	regulates	regulate	VBZ
cord-263157-8jin6oru	217	13	CCR5	CCR5	NNP
cord-263157-8jin6oru	217	14	when	when	WRB
cord-263157-8jin6oru	217	15	introduced	introduce	VBN
cord-263157-8jin6oru	217	16	via	via	IN
cord-263157-8jin6oru	217	17	CD34	CD34	NNP
cord-263157-8jin6oru	217	18	+	+	CC
cord-263157-8jin6oru	217	19	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	217	20	stem	stem	NN
cord-263157-8jin6oru	217	21	cell	cell	NN
cord-263157-8jin6oru	217	22	transplant	transplant	NN
cord-263157-8jin6oru	217	23	in	in	IN
cord-263157-8jin6oru	217	24	non	non	JJ
cord-263157-8jin6oru	217	25	-	-	JJ
cord-263157-8jin6oru	217	26	human	human	JJ
cord-263157-8jin6oru	217	27	primates	primate	NNS
cord-263157-8jin6oru	217	28	(	(	-LRB-
cord-263157-8jin6oru	217	29	84	84	CD
cord-263157-8jin6oru	217	30	)	)	-RRB-
cord-263157-8jin6oru	218	1	and	and	CC
cord-263157-8jin6oru	218	2	these	these	DT
cord-263157-8jin6oru	218	3	cells	cell	NNS
cord-263157-8jin6oru	218	4	were	be	VBD
cord-263157-8jin6oru	218	5	less	less	RBR
cord-263157-8jin6oru	218	6	susceptible	susceptible	JJ
cord-263157-8jin6oru	218	7	to	to	IN
cord-263157-8jin6oru	218	8	simian	simian	JJ
cord-263157-8jin6oru	218	9	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	218	10	virus	virus	NN
cord-263157-8jin6oru	218	11	(	(	-LRB-
cord-263157-8jin6oru	218	12	SIV	SIV	NNP
cord-263157-8jin6oru	218	13	)	)	-RRB-
cord-263157-8jin6oru	218	14	infection	infection	NN
cord-263157-8jin6oru	218	15	ex	ex	FW
cord-263157-8jin6oru	218	16	vivo	vivo	NN
cord-263157-8jin6oru	218	17	.	.	.
cord-263157-8jin6oru	219	1	Recently	recently	RB
cord-263157-8jin6oru	219	2	,	,	,
cord-263157-8jin6oru	219	3	several	several	JJ
cord-263157-8jin6oru	219	4	CCR5	CCR5	NNP
cord-263157-8jin6oru	219	5	antagonists	antagonist	NNS
cord-263157-8jin6oru	219	6	examined	examine	VBN
cord-263157-8jin6oru	219	7	in	in	IN
cord-263157-8jin6oru	219	8	clinical	clinical	JJ
cord-263157-8jin6oru	219	9	trials	trial	NNS
cord-263157-8jin6oru	219	10	were	be	VBD
cord-263157-8jin6oru	219	11	able	able	JJ
cord-263157-8jin6oru	219	12	to	to	TO
cord-263157-8jin6oru	219	13	reduce	reduce	VB
cord-263157-8jin6oru	219	14	plasma	plasma	NN
cord-263157-8jin6oru	219	15	viral	viral	JJ
cord-263157-8jin6oru	219	16	loads	load	NNS
cord-263157-8jin6oru	219	17	by	by	IN
cord-263157-8jin6oru	219	18	more	more	JJR
cord-263157-8jin6oru	219	19	than	than	IN
cord-263157-8jin6oru	219	20	one	one	CD
cord-263157-8jin6oru	219	21	order	order	NN
cord-263157-8jin6oru	219	22	of	of	IN
cord-263157-8jin6oru	219	23	magnitude	magnitude	NN
cord-263157-8jin6oru	219	24	during	during	IN
cord-263157-8jin6oru	219	25	treatment	treatment	NN
cord-263157-8jin6oru	219	26	(	(	-LRB-
cord-263157-8jin6oru	219	27	11	11	CD
cord-263157-8jin6oru	219	28	)	)	-RRB-
cord-263157-8jin6oru	219	29	.	.	.
cord-263157-8jin6oru	220	1	Although	although	IN
cord-263157-8jin6oru	220	2	,	,	,
cord-263157-8jin6oru	220	3	CCR5	CCR5	NNP
cord-263157-8jin6oru	220	4	antagonists	antagonist	NNS
cord-263157-8jin6oru	220	5	hold	hold	VBP
cord-263157-8jin6oru	220	6	great	great	JJ
cord-263157-8jin6oru	220	7	promise	promise	NN
cord-263157-8jin6oru	220	8	,	,	,
cord-263157-8jin6oru	220	9	the	the	DT
cord-263157-8jin6oru	220	10	long	long	JJ
cord-263157-8jin6oru	220	11	-	-	HYPH
cord-263157-8jin6oru	220	12	term	term	NN
cord-263157-8jin6oru	220	13	toxicity	toxicity	NN
cord-263157-8jin6oru	220	14	associated	associate	VBN
cord-263157-8jin6oru	220	15	with	with	IN
cord-263157-8jin6oru	220	16	the	the	DT
cord-263157-8jin6oru	220	17	impairment	impairment	NN
cord-263157-8jin6oru	220	18	of	of	IN
cord-263157-8jin6oru	220	19	CCR5	CCR5	NNP
cord-263157-8jin6oru	220	20	function	function	NN
cord-263157-8jin6oru	220	21	remains	remain	VBZ
cord-263157-8jin6oru	220	22	to	to	TO
cord-263157-8jin6oru	220	23	be	be	VB
cord-263157-8jin6oru	220	24	addressed	address	VBN
cord-263157-8jin6oru	220	25	.	.	.
cord-263157-8jin6oru	221	1	Targeting	target	VBG
cord-263157-8jin6oru	221	2	cellular	cellular	JJ
cord-263157-8jin6oru	221	3	factors	factor	NNS
cord-263157-8jin6oru	221	4	will	will	MD
cord-263157-8jin6oru	221	5	require	require	VB
cord-263157-8jin6oru	221	6	extensive	extensive	JJ
cord-263157-8jin6oru	221	7	toxicity	toxicity	NN
cord-263157-8jin6oru	221	8	studies	study	NNS
cord-263157-8jin6oru	221	9	.	.	.
cord-263157-8jin6oru	222	1	Delivery	delivery	NN
cord-263157-8jin6oru	222	2	remains	remain	VBZ
cord-263157-8jin6oru	222	3	a	a	DT
cord-263157-8jin6oru	222	4	major	major	JJ
cord-263157-8jin6oru	222	5	hurdle	hurdle	NN
cord-263157-8jin6oru	222	6	for	for	IN
cord-263157-8jin6oru	222	7	RNAi	RNAi	NNP
cord-263157-8jin6oru	222	8	therapy	therapy	NN
cord-263157-8jin6oru	222	9	,	,	,
cord-263157-8jin6oru	222	10	as	as	IN
cord-263157-8jin6oru	222	11	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	222	12	are	be	VBP
cord-263157-8jin6oru	222	13	unable	unable	JJ
cord-263157-8jin6oru	222	14	to	to	TO
cord-263157-8jin6oru	222	15	cross	cross	VB
cord-263157-8jin6oru	222	16	the	the	DT
cord-263157-8jin6oru	222	17	mammalian	mammalian	JJ
cord-263157-8jin6oru	222	18	cell	cell	NN
cord-263157-8jin6oru	222	19	membrane	membrane	NN
cord-263157-8jin6oru	222	20	without	without	IN
cord-263157-8jin6oru	222	21	aid	aid	NN
cord-263157-8jin6oru	222	22	.	.	.
cord-263157-8jin6oru	223	1	Most	Most	JJS
cord-263157-8jin6oru	223	2	of	of	IN
cord-263157-8jin6oru	223	3	the	the	DT
cord-263157-8jin6oru	223	4	ex	ex	FW
cord-263157-8jin6oru	223	5	vivo	vivo	NN
cord-263157-8jin6oru	223	6	transfection	transfection	NN
cord-263157-8jin6oru	223	7	methods	method	NNS
cord-263157-8jin6oru	223	8	used	use	VBN
cord-263157-8jin6oru	223	9	for	for	IN
cord-263157-8jin6oru	223	10	delivering	deliver	VBG
cord-263157-8jin6oru	223	11	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	223	12	can	can	MD
cord-263157-8jin6oru	223	13	not	not	RB
cord-263157-8jin6oru	223	14	be	be	VB
cord-263157-8jin6oru	223	15	used	use	VBN
cord-263157-8jin6oru	223	16	in	in	IN
cord-263157-8jin6oru	223	17	vivo	vivo	NN
cord-263157-8jin6oru	223	18	.	.	.
cord-263157-8jin6oru	224	1	There	there	EX
cord-263157-8jin6oru	224	2	are	be	VBP
cord-263157-8jin6oru	224	3	two	two	CD
cord-263157-8jin6oru	224	4	strategies	strategy	NNS
cord-263157-8jin6oru	224	5	for	for	IN
cord-263157-8jin6oru	224	6	delivering	deliver	VBG
cord-263157-8jin6oru	224	7	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	224	8	in	in	IN
cord-263157-8jin6oru	224	9	vivo	vivo	NN
cord-263157-8jin6oru	224	10	.	.	.
cord-263157-8jin6oru	225	1	As	as	IN
cord-263157-8jin6oru	225	2	discussed	discuss	VBN
cord-263157-8jin6oru	225	3	in	in	IN
cord-263157-8jin6oru	225	4	the	the	DT
cord-263157-8jin6oru	225	5	previous	previous	JJ
cord-263157-8jin6oru	225	6	section	section	NN
cord-263157-8jin6oru	225	7	,	,	,
cord-263157-8jin6oru	225	8	one	one	CD
cord-263157-8jin6oru	225	9	is	be	VBZ
cord-263157-8jin6oru	225	10	to	to	TO
cord-263157-8jin6oru	225	11	stably	stably	RB
cord-263157-8jin6oru	225	12	express	express	VB
cord-263157-8jin6oru	225	13	siRNA	siRNA	NNP
cord-263157-8jin6oru	225	14	precursors	precursor	NNS
cord-263157-8jin6oru	225	15	,	,	,
cord-263157-8jin6oru	225	16	such	such	JJ
cord-263157-8jin6oru	225	17	as	as	IN
cord-263157-8jin6oru	225	18	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	225	19	,	,	,
cord-263157-8jin6oru	225	20	from	from	IN
cord-263157-8jin6oru	225	21	viral	viral	JJ
cord-263157-8jin6oru	225	22	vectors	vector	NNS
cord-263157-8jin6oru	225	23	using	use	VBG
cord-263157-8jin6oru	225	24	gene	gene	NN
cord-263157-8jin6oru	225	25	therapy	therapy	NN
cord-263157-8jin6oru	225	26	technology	technology	NN
cord-263157-8jin6oru	225	27	;	;	:
cord-263157-8jin6oru	225	28	the	the	DT
cord-263157-8jin6oru	225	29	other	other	JJ
cord-263157-8jin6oru	225	30	is	be	VBZ
cord-263157-8jin6oru	225	31	to	to	TO
cord-263157-8jin6oru	225	32	deliver	deliver	VB
cord-263157-8jin6oru	225	33	synthetic	synthetic	JJ
cord-263157-8jin6oru	225	34	siRNAs	sirna	NNS
cord-263157-8jin6oru	225	35	naked	naked	JJ
cord-263157-8jin6oru	225	36	or	or	CC
cord-263157-8jin6oru	225	37	by	by	IN
cord-263157-8jin6oru	225	38	complexing	complexe	VBG
cord-263157-8jin6oru	225	39	or	or	CC
cord-263157-8jin6oru	225	40	covalently	covalently	RB
cord-263157-8jin6oru	225	41	linking	link	VBG
cord-263157-8jin6oru	225	42	the	the	DT
cord-263157-8jin6oru	225	43	siRNA	siRNA	NNP
cord-263157-8jin6oru	225	44	with	with	IN
cord-263157-8jin6oru	225	45	lipids	lipid	NNS
cord-263157-8jin6oru	225	46	,	,	,
cord-263157-8jin6oru	225	47	aptamers	aptamer	NNS
cord-263157-8jin6oru	225	48	,	,	,
cord-263157-8jin6oru	225	49	peptides	peptide	NNS
cord-263157-8jin6oru	225	50	or	or	CC
cord-263157-8jin6oru	225	51	proteins	protein	NNS
cord-263157-8jin6oru	225	52	(	(	-LRB-
cord-263157-8jin6oru	225	53	85	85	CD
cord-263157-8jin6oru	225	54	)	)	-RRB-
cord-263157-8jin6oru	225	55	.	.	.
cord-263157-8jin6oru	226	1	Intranasal	Intranasal	NNP
cord-263157-8jin6oru	226	2	administration	administration	NN
cord-263157-8jin6oru	226	3	of	of	IN
cord-263157-8jin6oru	226	4	naked	naked	JJ
cord-263157-8jin6oru	226	5	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	226	6	either	either	CC
cord-263157-8jin6oru	226	7	in	in	IN
cord-263157-8jin6oru	226	8	saline	saline	NN
cord-263157-8jin6oru	226	9	or	or	CC
cord-263157-8jin6oru	226	10	with	with	IN
cord-263157-8jin6oru	226	11	excipients	excipient	NNS
cord-263157-8jin6oru	226	12	such	such	JJ
cord-263157-8jin6oru	226	13	as	as	IN
cord-263157-8jin6oru	226	14	5	5	CD
cord-263157-8jin6oru	226	15	%	%	NN
cord-263157-8jin6oru	226	16	dextrose	dextrose	NN
cord-263157-8jin6oru	226	17	or	or	CC
cord-263157-8jin6oru	226	18	lung	lung	NN
cord-263157-8jin6oru	226	19	surfactants	surfactant	NNS
cord-263157-8jin6oru	226	20	reduced	reduce	VBD
cord-263157-8jin6oru	226	21	the	the	DT
cord-263157-8jin6oru	226	22	viral	viral	JJ
cord-263157-8jin6oru	226	23	load	load	NN
cord-263157-8jin6oru	226	24	of	of	IN
cord-263157-8jin6oru	226	25	respiratory	respiratory	JJ
cord-263157-8jin6oru	226	26	syncytial	syncytial	JJ
cord-263157-8jin6oru	226	27	virus	virus	NN
cord-263157-8jin6oru	226	28	(	(	-LRB-
cord-263157-8jin6oru	226	29	RSV	RSV	NNP
cord-263157-8jin6oru	226	30	)	)	-RRB-
cord-263157-8jin6oru	226	31	and	and	CC
cord-263157-8jin6oru	226	32	parainfluenza	parainfluenza	NNP
cord-263157-8jin6oru	226	33	virus	virus	NN
cord-263157-8jin6oru	226	34	in	in	IN
cord-263157-8jin6oru	226	35	pediatric	pediatric	JJ
cord-263157-8jin6oru	226	36	or	or	CC
cord-263157-8jin6oru	226	37	immuno	immuno	JJ
cord-263157-8jin6oru	226	38	-	-	HYPH
cord-263157-8jin6oru	226	39	compromised	compromise	VBN
cord-263157-8jin6oru	226	40	individuals	individual	NNS
cord-263157-8jin6oru	226	41	by	by	IN
cord-263157-8jin6oru	226	42	more	more	JJR
cord-263157-8jin6oru	226	43	than	than	IN
cord-263157-8jin6oru	226	44	three	three	CD
cord-263157-8jin6oru	226	45	orders	order	NNS
cord-263157-8jin6oru	226	46	of	of	IN
cord-263157-8jin6oru	226	47	magnitude	magnitude	NN
cord-263157-8jin6oru	226	48	(	(	-LRB-
cord-263157-8jin6oru	226	49	86	86	CD
cord-263157-8jin6oru	226	50	,	,	,
cord-263157-8jin6oru	226	51	see	see	VB
cord-263157-8jin6oru	226	52	Chap	Chap	NNP
cord-263157-8jin6oru	226	53	.	.	.
cord-263157-8jin6oru	227	1	15	15	LS
cord-263157-8jin6oru	227	2	)	)	-RRB-
cord-263157-8jin6oru	227	3	.	.	.
cord-263157-8jin6oru	228	1	Similarly	similarly	RB
cord-263157-8jin6oru	228	2	,	,	,
cord-263157-8jin6oru	228	3	siRNA	siRNA	NNP
cord-263157-8jin6oru	228	4	intranasally	intranasally	RB
cord-263157-8jin6oru	228	5	administered	administer	VBN
cord-263157-8jin6oru	228	6	in	in	IN
cord-263157-8jin6oru	228	7	a	a	DT
cord-263157-8jin6oru	228	8	non	non	JJ
cord-263157-8jin6oru	228	9	-	-	JJ
cord-263157-8jin6oru	228	10	human	human	JJ
cord-263157-8jin6oru	228	11	primate	primate	NN
cord-263157-8jin6oru	228	12	model	model	NN
cord-263157-8jin6oru	228	13	of	of	IN
cord-263157-8jin6oru	228	14	severe	severe	JJ
cord-263157-8jin6oru	228	15	acute	acute	JJ
cord-263157-8jin6oru	228	16	respiratory	respiratory	JJ
cord-263157-8jin6oru	228	17	syndrome	syndrome	NN
cord-263157-8jin6oru	228	18	(	(	-LRB-
cord-263157-8jin6oru	228	19	SARS	SARS	NNP
cord-263157-8jin6oru	228	20	)	)	-RRB-
cord-263157-8jin6oru	228	21	corona	corona	NNP
cord-263157-8jin6oru	228	22	virus	virus	NN
cord-263157-8jin6oru	228	23	infection	infection	NN
cord-263157-8jin6oru	228	24	significant	significant	JJ
cord-263157-8jin6oru	228	25	inhibited	inhibit	VBN
cord-263157-8jin6oru	228	26	viral	viral	JJ
cord-263157-8jin6oru	228	27	replication	replication	NN
cord-263157-8jin6oru	228	28	in	in	IN
cord-263157-8jin6oru	228	29	the	the	DT
cord-263157-8jin6oru	228	30	lung	lung	NN
cord-263157-8jin6oru	228	31	(	(	-LRB-
cord-263157-8jin6oru	228	32	87	87	CD
cord-263157-8jin6oru	228	33	)	)	-RRB-
cord-263157-8jin6oru	228	34	.	.	.
cord-263157-8jin6oru	229	1	These	these	DT
cord-263157-8jin6oru	229	2	studies	study	NNS
cord-263157-8jin6oru	229	3	clearly	clearly	RB
cord-263157-8jin6oru	229	4	demonstrated	demonstrate	VBD
cord-263157-8jin6oru	229	5	the	the	DT
cord-263157-8jin6oru	229	6	utility	utility	NN
cord-263157-8jin6oru	229	7	of	of	IN
cord-263157-8jin6oru	229	8	RNAi	RNAi	NNS
cord-263157-8jin6oru	229	9	to	to	TO
cord-263157-8jin6oru	229	10	treat	treat	VB
cord-263157-8jin6oru	229	11	viral	viral	JJ
cord-263157-8jin6oru	229	12	respiratory	respiratory	JJ
cord-263157-8jin6oru	229	13	infections	infection	NNS
cord-263157-8jin6oru	229	14	.	.	.
cord-263157-8jin6oru	230	1	Liposomes	liposome	NNS
cord-263157-8jin6oru	230	2	,	,	,
cord-263157-8jin6oru	230	3	vesicles	vesicle	NNS
cord-263157-8jin6oru	230	4	with	with	IN
cord-263157-8jin6oru	230	5	an	an	DT
cord-263157-8jin6oru	230	6	aqueous	aqueous	JJ
cord-263157-8jin6oru	230	7	compartment	compartment	NN
cord-263157-8jin6oru	230	8	enclosed	enclose	VBN
cord-263157-8jin6oru	230	9	in	in	IN
cord-263157-8jin6oru	230	10	a	a	DT
cord-263157-8jin6oru	230	11	phospholipid	phospholipid	NN
cord-263157-8jin6oru	230	12	bilayer	bilayer	NN
cord-263157-8jin6oru	230	13	that	that	WDT
cord-263157-8jin6oru	230	14	can	can	MD
cord-263157-8jin6oru	230	15	fuse	fuse	VB
cord-263157-8jin6oru	230	16	with	with	IN
cord-263157-8jin6oru	230	17	cell	cell	NN
cord-263157-8jin6oru	230	18	membranes	membrane	NNS
cord-263157-8jin6oru	230	19	and	and	CC
cord-263157-8jin6oru	230	20	enhance	enhance	VB
cord-263157-8jin6oru	230	21	drug	drug	NN
cord-263157-8jin6oru	230	22	delivery	delivery	NN
cord-263157-8jin6oru	230	23	into	into	IN
cord-263157-8jin6oru	230	24	cells	cell	NNS
cord-263157-8jin6oru	230	25	,	,	,
cord-263157-8jin6oru	230	26	have	have	VBP
cord-263157-8jin6oru	230	27	been	be	VBN
cord-263157-8jin6oru	230	28	extensively	extensively	RB
cord-263157-8jin6oru	230	29	used	use	VBN
cord-263157-8jin6oru	230	30	to	to	TO
cord-263157-8jin6oru	230	31	deliver	deliver	VB
cord-263157-8jin6oru	230	32	siRNA	siRNA	NNP
cord-263157-8jin6oru	230	33	in	in	IN
cord-263157-8jin6oru	230	34	vitro	vitro	FW
cord-263157-8jin6oru	230	35	and	and	CC
cord-263157-8jin6oru	230	36	in	in	IN
cord-263157-8jin6oru	230	37	vivo	vivo	NNP
cord-263157-8jin6oru	230	38	.	.	.
cord-263157-8jin6oru	231	1	In	in	IN
cord-263157-8jin6oru	231	2	vitro	vitro	FW
cord-263157-8jin6oru	231	3	transfection	transfection	NN
cord-263157-8jin6oru	231	4	of	of	IN
cord-263157-8jin6oru	231	5	siRNA	siRNA	NNP
cord-263157-8jin6oru	231	6	using	use	VBG
cord-263157-8jin6oru	231	7	lipid	lipid	NN
cord-263157-8jin6oru	231	8	-	-	HYPH
cord-263157-8jin6oru	231	9	based	base	VBN
cord-263157-8jin6oru	231	10	delivery	delivery	NN
cord-263157-8jin6oru	231	11	agents	agent	NNS
cord-263157-8jin6oru	231	12	is	be	VBZ
cord-263157-8jin6oru	231	13	a	a	DT
cord-263157-8jin6oru	231	14	routine	routine	JJ
cord-263157-8jin6oru	231	15	laboratory	laboratory	NN
cord-263157-8jin6oru	231	16	procedure	procedure	NN
cord-263157-8jin6oru	231	17	.	.	.
cord-263157-8jin6oru	232	1	Lipid	lipid	NN
cord-263157-8jin6oru	232	2	-	-	HYPH
cord-263157-8jin6oru	232	3	based	base	VBN
cord-263157-8jin6oru	232	4	formulations	formulation	NNS
cord-263157-8jin6oru	232	5	effectively	effectively	RB
cord-263157-8jin6oru	232	6	delivered	deliver	VBD
cord-263157-8jin6oru	232	7	siRNA	siRNA	NNP
cord-263157-8jin6oru	232	8	to	to	IN
cord-263157-8jin6oru	232	9	the	the	DT
cord-263157-8jin6oru	232	10	liver	liver	NN
cord-263157-8jin6oru	232	11	in	in	IN
cord-263157-8jin6oru	232	12	animal	animal	NN
cord-263157-8jin6oru	232	13	models	model	NNS
cord-263157-8jin6oru	232	14	of	of	IN
cord-263157-8jin6oru	232	15	hepatitis	hepatitis	NNP
cord-263157-8jin6oru	232	16	B	B	NNP
cord-263157-8jin6oru	232	17	and	and	CC
cord-263157-8jin6oru	232	18	Ebola	Ebola	NNP
cord-263157-8jin6oru	232	19	virus	virus	NN
cord-263157-8jin6oru	232	20	infection	infection	NN
cord-263157-8jin6oru	232	21	(	(	-LRB-
cord-263157-8jin6oru	232	22	88	88	CD
cord-263157-8jin6oru	232	23	,	,	,
cord-263157-8jin6oru	232	24	89	89	CD
cord-263157-8jin6oru	232	25	)	)	-RRB-
cord-263157-8jin6oru	232	26	.	.	.
cord-263157-8jin6oru	233	1	Locally	locally	RB
cord-263157-8jin6oru	233	2	injected	inject	VBN
cord-263157-8jin6oru	233	3	liposomes	liposome	NNS
cord-263157-8jin6oru	233	4	have	have	VBP
cord-263157-8jin6oru	233	5	also	also	RB
cord-263157-8jin6oru	233	6	delivered	deliver	VBN
cord-263157-8jin6oru	233	7	siRNA	siRNA	NNP
cord-263157-8jin6oru	233	8	effectively	effectively	RB
cord-263157-8jin6oru	233	9	to	to	TO
cord-263157-8jin6oru	233	10	target	target	VB
cord-263157-8jin6oru	233	11	cells	cell	NNS
cord-263157-8jin6oru	233	12	in	in	IN
cord-263157-8jin6oru	233	13	the	the	DT
cord-263157-8jin6oru	233	14	eye	eye	NN
cord-263157-8jin6oru	233	15	and	and	CC
cord-263157-8jin6oru	233	16	nervous	nervous	JJ
cord-263157-8jin6oru	233	17	system	system	NN
cord-263157-8jin6oru	233	18	,	,	,
cord-263157-8jin6oru	233	19	and	and	CC
cord-263157-8jin6oru	233	20	to	to	IN
cord-263157-8jin6oru	233	21	tumors	tumor	NNS
cord-263157-8jin6oru	233	22	(	(	-LRB-
cord-263157-8jin6oru	233	23	85	85	CD
cord-263157-8jin6oru	233	24	)	)	-RRB-
cord-263157-8jin6oru	233	25	.	.	.
cord-263157-8jin6oru	234	1	Topical	topical	JJ
cord-263157-8jin6oru	234	2	delivery	delivery	NN
cord-263157-8jin6oru	234	3	of	of	IN
cord-263157-8jin6oru	234	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	234	5	using	use	VBG
cord-263157-8jin6oru	234	6	liposomes	liposome	NNS
cord-263157-8jin6oru	234	7	may	may	MD
cord-263157-8jin6oru	234	8	be	be	VB
cord-263157-8jin6oru	234	9	especially	especially	RB
cord-263157-8jin6oru	234	10	effective	effective	JJ
cord-263157-8jin6oru	234	11	.	.	.
cord-263157-8jin6oru	235	1	Intravaginal	Intravaginal	NNP
cord-263157-8jin6oru	235	2	application	application	NN
cord-263157-8jin6oru	235	3	of	of	IN
cord-263157-8jin6oru	235	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	235	5	protected	protect	VBN
cord-263157-8jin6oru	235	6	mice	mouse	NNS
cord-263157-8jin6oru	235	7	from	from	IN
cord-263157-8jin6oru	235	8	lethal	lethal	JJ
cord-263157-8jin6oru	235	9	herpes	herpes	NN
cord-263157-8jin6oru	235	10	simple	simple	JJ
cord-263157-8jin6oru	235	11	virus	virus	NN
cord-263157-8jin6oru	235	12	type	type	NN
cord-263157-8jin6oru	235	13	2	2	CD
cord-263157-8jin6oru	236	1	(	(	-LRB-
cord-263157-8jin6oru	236	2	HSV-2	HSV-2	NNP
cord-263157-8jin6oru	236	3	)	)	-RRB-
cord-263157-8jin6oru	236	4	sexually	sexually	RB
cord-263157-8jin6oru	236	5	transmitted	transmit	VBN
cord-263157-8jin6oru	236	6	infection	infection	NN
cord-263157-8jin6oru	236	7	(	(	-LRB-
cord-263157-8jin6oru	236	8	90	90	CD
cord-263157-8jin6oru	236	9	)	)	-RRB-
cord-263157-8jin6oru	236	10	.	.	.
cord-263157-8jin6oru	237	1	The	the	DT
cord-263157-8jin6oru	237	2	cervical	cervical	JJ
cord-263157-8jin6oru	237	3	/	/	SYM
cord-263157-8jin6oru	237	4	vaginal	vaginal	JJ
cord-263157-8jin6oru	237	5	mucosa	mucosa	NN
cord-263157-8jin6oru	237	6	is	be	VBZ
cord-263157-8jin6oru	237	7	the	the	DT
cord-263157-8jin6oru	237	8	main	main	JJ
cord-263157-8jin6oru	237	9	port	port	NN
cord-263157-8jin6oru	237	10	of	of	IN
cord-263157-8jin6oru	237	11	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	237	12	entry	entry	NN
cord-263157-8jin6oru	237	13	in	in	IN
cord-263157-8jin6oru	237	14	women	woman	NNS
cord-263157-8jin6oru	237	15	,	,	,
cord-263157-8jin6oru	237	16	thus	thus	RB
cord-263157-8jin6oru	237	17	an	an	DT
cord-263157-8jin6oru	237	18	effective	effective	JJ
cord-263157-8jin6oru	237	19	topical	topical	JJ
cord-263157-8jin6oru	237	20	microbicide	microbicide	NN
cord-263157-8jin6oru	237	21	against	against	IN
cord-263157-8jin6oru	237	22	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	237	23	may	may	MD
cord-263157-8jin6oru	237	24	be	be	VB
cord-263157-8jin6oru	237	25	useful	useful	JJ
cord-263157-8jin6oru	237	26	to	to	TO
cord-263157-8jin6oru	237	27	prevent	prevent	VB
cord-263157-8jin6oru	237	28	sexual	sexual	JJ
cord-263157-8jin6oru	237	29	transmission	transmission	NN
cord-263157-8jin6oru	237	30	.	.	.
cord-263157-8jin6oru	238	1	Since	since	IN
cord-263157-8jin6oru	238	2	the	the	DT
cord-263157-8jin6oru	238	3	cellular	cellular	JJ
cord-263157-8jin6oru	238	4	coreceptor	coreceptor	NN
cord-263157-8jin6oru	238	5	CCR5	CCR5	NNP
cord-263157-8jin6oru	238	6	is	be	VBZ
cord-263157-8jin6oru	238	7	required	require	VBN
cord-263157-8jin6oru	238	8	for	for	IN
cord-263157-8jin6oru	238	9	infection	infection	NN
cord-263157-8jin6oru	238	10	by	by	IN
cord-263157-8jin6oru	238	11	the	the	DT
cord-263157-8jin6oru	238	12	majority	majority	NN
cord-263157-8jin6oru	238	13	of	of	IN
cord-263157-8jin6oru	238	14	primary	primary	JJ
cord-263157-8jin6oru	238	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	238	16	isolates	isolate	NNS
cord-263157-8jin6oru	238	17	,	,	,
cord-263157-8jin6oru	238	18	a	a	DT
cord-263157-8jin6oru	238	19	lipid	lipid	NN
cord-263157-8jin6oru	238	20	-	-	HYPH
cord-263157-8jin6oru	238	21	formulated	formulate	VBN
cord-263157-8jin6oru	238	22	siRNA	siRNA	NNP
cord-263157-8jin6oru	238	23	against	against	IN
cord-263157-8jin6oru	238	24	the	the	DT
cord-263157-8jin6oru	238	25	CCR5	CCR5	NNP
cord-263157-8jin6oru	238	26	transcripts	transcript	NNS
cord-263157-8jin6oru	238	27	will	will	MD
cord-263157-8jin6oru	238	28	be	be	VB
cord-263157-8jin6oru	238	29	an	an	DT
cord-263157-8jin6oru	238	30	excellent	excellent	JJ
cord-263157-8jin6oru	238	31	candidate	candidate	NN
cord-263157-8jin6oru	238	32	for	for	IN
cord-263157-8jin6oru	238	33	anti	anti	JJ
cord-263157-8jin6oru	238	34	-	-	NNP
cord-263157-8jin6oru	238	35	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	238	36	microbicide	microbicide	NN
cord-263157-8jin6oru	238	37	.	.	.
cord-263157-8jin6oru	239	1	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	239	2	can	can	MD
cord-263157-8jin6oru	239	3	be	be	VB
cord-263157-8jin6oru	239	4	complexed	complexe	VBN
cord-263157-8jin6oru	239	5	with	with	IN
cord-263157-8jin6oru	239	6	cationic	cationic	JJ
cord-263157-8jin6oru	239	7	peptides	peptide	NNS
cord-263157-8jin6oru	239	8	and	and	CC
cord-263157-8jin6oru	239	9	polymers	polymer	NNS
cord-263157-8jin6oru	239	10	to	to	TO
cord-263157-8jin6oru	239	11	form	form	VB
cord-263157-8jin6oru	239	12	stable	stable	JJ
cord-263157-8jin6oru	239	13	nanoparticles	nanoparticle	NNS
cord-263157-8jin6oru	239	14	via	via	IN
cord-263157-8jin6oru	239	15	ionic	ionic	JJ
cord-263157-8jin6oru	239	16	interactions	interaction	NNS
cord-263157-8jin6oru	239	17	with	with	IN
cord-263157-8jin6oru	239	18	their	-PRON-	PRP$
cord-263157-8jin6oru	239	19	negatively	negatively	RB
cord-263157-8jin6oru	239	20	charged	charge	VBN
cord-263157-8jin6oru	239	21	phosphate	phosphate	NN
cord-263157-8jin6oru	239	22	backbones	backbone	NNS
cord-263157-8jin6oru	239	23	(	(	-LRB-
cord-263157-8jin6oru	239	24	91	91	CD
cord-263157-8jin6oru	239	25	)	)	-RRB-
cord-263157-8jin6oru	239	26	.	.	.
cord-263157-8jin6oru	240	1	Similarly	similarly	RB
cord-263157-8jin6oru	240	2	,	,	,
cord-263157-8jin6oru	240	3	one	one	CD
cord-263157-8jin6oru	240	4	study	study	NN
cord-263157-8jin6oru	240	5	showed	show	VBD
cord-263157-8jin6oru	240	6	that	that	IN
cord-263157-8jin6oru	240	7	a	a	DT
cord-263157-8jin6oru	240	8	protamine	protamine	NNP
cord-263157-8jin6oru	240	9	antibody	antibody	NN
cord-263157-8jin6oru	240	10	fusion	fusion	NN
cord-263157-8jin6oru	240	11	protein	protein	NN
cord-263157-8jin6oru	240	12	delivered	deliver	VBD
cord-263157-8jin6oru	240	13	non	non	NNP
cord-263157-8jin6oru	240	14	-	-	NN
cord-263157-8jin6oru	240	15	covalently	covalently	RB
cord-263157-8jin6oru	240	16	bound	bind	VBN
cord-263157-8jin6oru	240	17	siRNA	siRNA	NNP
cord-263157-8jin6oru	240	18	to	to	IN
cord-263157-8jin6oru	240	19	HIV-1-infected	hiv-1-infecte	VBN
cord-263157-8jin6oru	240	20	primary	primary	JJ
cord-263157-8jin6oru	240	21	CD4	CD4	NNP
cord-263157-8jin6oru	240	22	+	+	CC
cord-263157-8jin6oru	240	23	T	T	NNP
cord-263157-8jin6oru	240	24	cells	cell	NNS
cord-263157-8jin6oru	240	25	in	in	IN
cord-263157-8jin6oru	240	26	vitro	vitro	FW
cord-263157-8jin6oru	240	27	with	with	IN
cord-263157-8jin6oru	240	28	high	high	JJ
cord-263157-8jin6oru	240	29	efficiency	efficiency	NN
cord-263157-8jin6oru	240	30	(	(	-LRB-
cord-263157-8jin6oru	240	31	92	92	CD
cord-263157-8jin6oru	240	32	)	)	-RRB-
cord-263157-8jin6oru	240	33	.	.	.
cord-263157-8jin6oru	241	1	In	in	IN
cord-263157-8jin6oru	241	2	this	this	DT
cord-263157-8jin6oru	241	3	approach	approach	NN
cord-263157-8jin6oru	241	4	,	,	,
cord-263157-8jin6oru	241	5	the	the	DT
cord-263157-8jin6oru	241	6	Fab	Fab	NNP
cord-263157-8jin6oru	241	7	fragment	fragment	NN
cord-263157-8jin6oru	241	8	of	of	IN
cord-263157-8jin6oru	241	9	an	an	DT
cord-263157-8jin6oru	241	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	241	11	envelope	envelope	NN
cord-263157-8jin6oru	241	12	antibody	antibody	NN
cord-263157-8jin6oru	241	13	mediates	mediate	VBZ
cord-263157-8jin6oru	241	14	receptorspecific	receptorspecific	NNP
cord-263157-8jin6oru	241	15	binding	bind	VBG
cord-263157-8jin6oru	241	16	to	to	IN
cord-263157-8jin6oru	241	17	cells	cell	NNS
cord-263157-8jin6oru	241	18	expressing	express	VBG
cord-263157-8jin6oru	241	19	the	the	DT
cord-263157-8jin6oru	241	20	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	241	21	envelope	envelope	NN
cord-263157-8jin6oru	241	22	protein	protein	NN
cord-263157-8jin6oru	241	23	,	,	,
cord-263157-8jin6oru	241	24	illustrating	illustrate	VBG
cord-263157-8jin6oru	241	25	the	the	DT
cord-263157-8jin6oru	241	26	potential	potential	NN
cord-263157-8jin6oru	241	27	for	for	IN
cord-263157-8jin6oru	241	28	antibodies	antibody	NNS
cord-263157-8jin6oru	241	29	to	to	TO
cord-263157-8jin6oru	241	30	also	also	RB
cord-263157-8jin6oru	241	31	direct	direct	VB
cord-263157-8jin6oru	241	32	siRNA	siRNA	NNP
cord-263157-8jin6oru	241	33	selectively	selectively	RB
cord-263157-8jin6oru	241	34	into	into	IN
cord-263157-8jin6oru	241	35	cells	cell	NNS
cord-263157-8jin6oru	241	36	in	in	IN
cord-263157-8jin6oru	241	37	vivo	vivo	NN
cord-263157-8jin6oru	241	38	.	.	.
cord-263157-8jin6oru	242	1	Given	give	VBN
cord-263157-8jin6oru	242	2	the	the	DT
cord-263157-8jin6oru	242	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	242	4	life	life	NN
cord-263157-8jin6oru	242	5	cycle	cycle	NN
cord-263157-8jin6oru	242	6	,	,	,
cord-263157-8jin6oru	242	7	in	in	IN
cord-263157-8jin6oru	242	8	which	which	WDT
cord-263157-8jin6oru	242	9	the	the	DT
cord-263157-8jin6oru	242	10	persistence	persistence	NN
cord-263157-8jin6oru	242	11	of	of	IN
cord-263157-8jin6oru	242	12	a	a	DT
cord-263157-8jin6oru	242	13	latent	latent	JJ
cord-263157-8jin6oru	242	14	reservoir	reservoir	NN
cord-263157-8jin6oru	242	15	of	of	IN
cord-263157-8jin6oru	242	16	resting	rest	VBG
cord-263157-8jin6oru	242	17	infected	infected	JJ
cord-263157-8jin6oru	242	18	cells	cell	NNS
cord-263157-8jin6oru	242	19	makes	make	VBZ
cord-263157-8jin6oru	242	20	eradication	eradication	NN
cord-263157-8jin6oru	242	21	of	of	IN
cord-263157-8jin6oru	242	22	the	the	DT
cord-263157-8jin6oru	242	23	virus	virus	NN
cord-263157-8jin6oru	242	24	from	from	IN
cord-263157-8jin6oru	242	25	infected	infected	JJ
cord-263157-8jin6oru	242	26	individuals	individual	NNS
cord-263157-8jin6oru	242	27	extremely	extremely	RB
cord-263157-8jin6oru	242	28	difficult	difficult	JJ
cord-263157-8jin6oru	242	29	,	,	,
cord-263157-8jin6oru	242	30	the	the	DT
cord-263157-8jin6oru	242	31	most	most	RBS
cord-263157-8jin6oru	242	32	promising	promising	JJ
cord-263157-8jin6oru	242	33	strategy	strategy	NN
cord-263157-8jin6oru	242	34	for	for	IN
cord-263157-8jin6oru	242	35	in	in	IN
cord-263157-8jin6oru	242	36	vivo	vivo	NN
cord-263157-8jin6oru	242	37	delivery	delivery	NN
cord-263157-8jin6oru	242	38	of	of	IN
cord-263157-8jin6oru	242	39	siRNA	siRNA	NNP
cord-263157-8jin6oru	242	40	is	be	VBZ
cord-263157-8jin6oru	242	41	the	the	DT
cord-263157-8jin6oru	242	42	use	use	NN
cord-263157-8jin6oru	242	43	of	of	IN
cord-263157-8jin6oru	242	44	gene	gene	NN
cord-263157-8jin6oru	242	45	therapy	therapy	NN
cord-263157-8jin6oru	242	46	approaches	approach	NNS
cord-263157-8jin6oru	242	47	.	.	.
cord-263157-8jin6oru	243	1	Because	because	IN
cord-263157-8jin6oru	243	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	243	3	predominately	predominately	RB
cord-263157-8jin6oru	243	4	infects	infect	VBZ
cord-263157-8jin6oru	243	5	T	t	NN
cord-263157-8jin6oru	243	6	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	243	7	and	and	CC
cord-263157-8jin6oru	243	8	macrophages	macrophage	NNS
cord-263157-8jin6oru	243	9	,	,	,
cord-263157-8jin6oru	243	10	blood	blood	NN
cord-263157-8jin6oru	243	11	CD34	CD34	NNP
cord-263157-8jin6oru	243	12	+	+	CC
cord-263157-8jin6oru	243	13	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	243	14	stem	stem	NN
cord-263157-8jin6oru	243	15	cell	cell	NN
cord-263157-8jin6oru	243	16	transplant	transplant	NN
cord-263157-8jin6oru	243	17	could	could	MD
cord-263157-8jin6oru	243	18	be	be	VB
cord-263157-8jin6oru	243	19	the	the	DT
cord-263157-8jin6oru	243	20	best	good	JJS
cord-263157-8jin6oru	243	21	strategy	strategy	NN
cord-263157-8jin6oru	243	22	,	,	,
cord-263157-8jin6oru	243	23	in	in	IN
cord-263157-8jin6oru	243	24	which	which	WDT
cord-263157-8jin6oru	243	25	progeny	progeny	NN
cord-263157-8jin6oru	243	26	cells	cell	NNS
cord-263157-8jin6oru	243	27	would	would	MD
cord-263157-8jin6oru	243	28	stably	stably	RB
cord-263157-8jin6oru	243	29	express	express	VB
cord-263157-8jin6oru	243	30	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	243	31	that	that	IN
cord-263157-8jin6oru	243	32	down	down	RB
cord-263157-8jin6oru	243	33	-	-	HYPH
cord-263157-8jin6oru	243	34	regulate	regulate	VB
cord-263157-8jin6oru	243	35	viral	viral	JJ
cord-263157-8jin6oru	243	36	or	or	CC
cord-263157-8jin6oru	243	37	cellular	cellular	JJ
cord-263157-8jin6oru	243	38	genes	gene	NNS
cord-263157-8jin6oru	243	39	that	that	WDT
cord-263157-8jin6oru	243	40	are	be	VBP
cord-263157-8jin6oru	243	41	targets	target	NNS
cord-263157-8jin6oru	243	42	for	for	IN
cord-263157-8jin6oru	243	43	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	243	44	infection	infection	NN
cord-263157-8jin6oru	243	45	.	.	.
cord-263157-8jin6oru	244	1	As	as	IN
cord-263157-8jin6oru	244	2	noted	note	VBN
cord-263157-8jin6oru	244	3	before	before	RB
cord-263157-8jin6oru	244	4	,	,	,
cord-263157-8jin6oru	244	5	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	244	6	can	can	MD
cord-263157-8jin6oru	244	7	infect	infect	VB
cord-263157-8jin6oru	244	8	resting	rest	VBG
cord-263157-8jin6oru	244	9	non	non	JJ
cord-263157-8jin6oru	244	10	-	-	JJ
cord-263157-8jin6oru	244	11	dividing	dividing	JJ
cord-263157-8jin6oru	244	12	CD4	CD4	NNP
cord-263157-8jin6oru	244	13	+	+	CC
cord-263157-8jin6oru	244	14	T	t	NN
cord-263157-8jin6oru	244	15	cells	cell	NNS
cord-263157-8jin6oru	244	16	,	,	,
cord-263157-8jin6oru	244	17	thus	thus	RB
cord-263157-8jin6oru	244	18	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	244	19	vectors	vector	NNS
cord-263157-8jin6oru	244	20	should	should	MD
cord-263157-8jin6oru	244	21	be	be	VB
cord-263157-8jin6oru	244	22	employed	employ	VBN
cord-263157-8jin6oru	244	23	over	over	IN
cord-263157-8jin6oru	244	24	murine	murine	JJ
cord-263157-8jin6oru	244	25	retroviral	retroviral	JJ
cord-263157-8jin6oru	244	26	vectors	vector	NNS
cord-263157-8jin6oru	244	27	,	,	,
cord-263157-8jin6oru	244	28	as	as	IN
cord-263157-8jin6oru	244	29	HIV-1-based	HIV-1-based	NNP
cord-263157-8jin6oru	244	30	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	244	31	vectors	vector	NNS
cord-263157-8jin6oru	244	32	have	have	VBP
cord-263157-8jin6oru	244	33	been	be	VBN
cord-263157-8jin6oru	244	34	shown	show	VBN
cord-263157-8jin6oru	244	35	to	to	TO
cord-263157-8jin6oru	244	36	be	be	VB
cord-263157-8jin6oru	244	37	particularly	particularly	RB
cord-263157-8jin6oru	244	38	suited	suit	VBN
cord-263157-8jin6oru	244	39	for	for	IN
cord-263157-8jin6oru	244	40	the	the	DT
cord-263157-8jin6oru	244	41	transduction	transduction	NN
cord-263157-8jin6oru	244	42	of	of	IN
cord-263157-8jin6oru	244	43	non	non	JJ
cord-263157-8jin6oru	244	44	-	-	JJ
cord-263157-8jin6oru	244	45	dividing	dividing	JJ
cord-263157-8jin6oru	244	46	cells	cell	NNS
cord-263157-8jin6oru	244	47	,	,	,
cord-263157-8jin6oru	244	48	such	such	JJ
cord-263157-8jin6oru	244	49	as	as	IN
cord-263157-8jin6oru	244	50	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	244	51	progenitor	progenitor	NN
cord-263157-8jin6oru	244	52	cells	cell	NNS
cord-263157-8jin6oru	244	53	(	(	-LRB-
cord-263157-8jin6oru	244	54	93	93	CD
cord-263157-8jin6oru	244	55	)	)	-RRB-
cord-263157-8jin6oru	244	56	.	.	.
cord-263157-8jin6oru	245	1	These	these	DT
cord-263157-8jin6oru	245	2	HIV-1-based	hiv-1-base	VBN
cord-263157-8jin6oru	245	3	vectors	vector	NNS
cord-263157-8jin6oru	245	4	seem	seem	VBP
cord-263157-8jin6oru	245	5	to	to	TO
cord-263157-8jin6oru	245	6	be	be	VB
cord-263157-8jin6oru	245	7	preferable	preferable	JJ
cord-263157-8jin6oru	245	8	candidates	candidate	NNS
cord-263157-8jin6oru	245	9	for	for	IN
cord-263157-8jin6oru	245	10	gene	gene	NN
cord-263157-8jin6oru	245	11	therapy	therapy	NN
cord-263157-8jin6oru	245	12	development	development	NN
cord-263157-8jin6oru	245	13	in	in	IN
cord-263157-8jin6oru	245	14	the	the	DT
cord-263157-8jin6oru	245	15	treatment	treatment	NN
cord-263157-8jin6oru	245	16	of	of	IN
cord-263157-8jin6oru	245	17	HIV-1-infected	hiv-1-infecte	VBN
cord-263157-8jin6oru	245	18	individuals	individual	NNS
cord-263157-8jin6oru	245	19	(	(	-LRB-
cord-263157-8jin6oru	245	20	94	94	CD
cord-263157-8jin6oru	245	21	)	)	-RRB-
cord-263157-8jin6oru	245	22	.	.	.
cord-263157-8jin6oru	246	1	However	however	RB
cord-263157-8jin6oru	246	2	,	,	,
cord-263157-8jin6oru	246	3	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	246	4	targeting	target	VBG
cord-263157-8jin6oru	246	5	highly	highly	RB
cord-263157-8jin6oru	246	6	conserved	conserve	VBN
cord-263157-8jin6oru	246	7	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	246	8	sequences	sequence	NNS
cord-263157-8jin6oru	246	9	may	may	MD
cord-263157-8jin6oru	246	10	be	be	VB
cord-263157-8jin6oru	246	11	an	an	DT
cord-263157-8jin6oru	246	12	obstacle	obstacle	NN
cord-263157-8jin6oru	246	13	in	in	IN
cord-263157-8jin6oru	246	14	vector	vector	NN
cord-263157-8jin6oru	246	15	production	production	NN
cord-263157-8jin6oru	246	16	,	,	,
cord-263157-8jin6oru	246	17	as	as	IN
cord-263157-8jin6oru	246	18	it	-PRON-	PRP
cord-263157-8jin6oru	246	19	has	have	VBZ
cord-263157-8jin6oru	246	20	been	be	VBN
cord-263157-8jin6oru	246	21	reported	report	VBN
cord-263157-8jin6oru	246	22	that	that	DT
cord-263157-8jin6oru	246	23	expression	expression	NN
cord-263157-8jin6oru	246	24	of	of	IN
cord-263157-8jin6oru	246	25	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	246	26	that	that	WDT
cord-263157-8jin6oru	246	27	target	target	NN
cord-263157-8jin6oru	246	28	also	also	RB
cord-263157-8jin6oru	246	29	the	the	DT
cord-263157-8jin6oru	246	30	delivering	deliver	VBG
cord-263157-8jin6oru	246	31	vector	vector	NN
cord-263157-8jin6oru	246	32	can	can	MD
cord-263157-8jin6oru	246	33	result	result	VB
cord-263157-8jin6oru	246	34	in	in	IN
cord-263157-8jin6oru	246	35	a	a	DT
cord-263157-8jin6oru	246	36	reduction	reduction	NN
cord-263157-8jin6oru	246	37	of	of	IN
cord-263157-8jin6oru	246	38	the	the	DT
cord-263157-8jin6oru	246	39	transduction	transduction	NN
cord-263157-8jin6oru	246	40	titer	titer	NN
cord-263157-8jin6oru	246	41	(	(	-LRB-
cord-263157-8jin6oru	246	42	23	23	CD
cord-263157-8jin6oru	246	43	)	)	-RRB-
cord-263157-8jin6oru	246	44	,	,	,
cord-263157-8jin6oru	246	45	suggesting	suggest	VBG
cord-263157-8jin6oru	246	46	that	that	IN
cord-263157-8jin6oru	246	47	these	these	DT
cord-263157-8jin6oru	246	48	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	246	49	could	could	MD
cord-263157-8jin6oru	246	50	cross	cross	VB
cord-263157-8jin6oru	246	51	-	-	VB
cord-263157-8jin6oru	246	52	react	react	VB
cord-263157-8jin6oru	246	53	with	with	IN
cord-263157-8jin6oru	246	54	critical	critical	JJ
cord-263157-8jin6oru	246	55	sequences	sequence	NNS
cord-263157-8jin6oru	246	56	of	of	IN
cord-263157-8jin6oru	246	57	the	the	DT
cord-263157-8jin6oru	246	58	vector	vector	NN
cord-263157-8jin6oru	246	59	.	.	.
cord-263157-8jin6oru	247	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	247	2	,	,	,
cord-263157-8jin6oru	247	3	new	new	JJ
cord-263157-8jin6oru	247	4	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	247	5	vectors	vector	NNS
cord-263157-8jin6oru	247	6	have	have	VBP
cord-263157-8jin6oru	247	7	been	be	VBN
cord-263157-8jin6oru	247	8	developed	develop	VBN
cord-263157-8jin6oru	247	9	to	to	TO
cord-263157-8jin6oru	247	10	overcome	overcome	VB
cord-263157-8jin6oru	247	11	this	this	DT
cord-263157-8jin6oru	247	12	issue	issue	NN
cord-263157-8jin6oru	247	13	,	,	,
cord-263157-8jin6oru	247	14	and	and	CC
cord-263157-8jin6oru	247	15	the	the	DT
cord-263157-8jin6oru	247	16	vector	vector	NN
cord-263157-8jin6oru	247	17	backbone	backbone	NN
cord-263157-8jin6oru	247	18	may	may	MD
cord-263157-8jin6oru	247	19	be	be	VB
cord-263157-8jin6oru	247	20	modified	modify	VBN
cord-263157-8jin6oru	247	21	by	by	IN
cord-263157-8jin6oru	247	22	point	point	NN
cord-263157-8jin6oru	247	23	mutations	mutation	NNS
cord-263157-8jin6oru	247	24	to	to	TO
cord-263157-8jin6oru	247	25	resist	resist	VB
cord-263157-8jin6oru	247	26	RNAi	RNAi	NNS
cord-263157-8jin6oru	247	27	-	-	HYPH
cord-263157-8jin6oru	247	28	mediated	mediate	VBN
cord-263157-8jin6oru	247	29	degradation	degradation	NN
cord-263157-8jin6oru	247	30	during	during	IN
cord-263157-8jin6oru	247	31	vector	vector	NN
cord-263157-8jin6oru	247	32	production	production	NN
cord-263157-8jin6oru	247	33	(	(	-LRB-
cord-263157-8jin6oru	247	34	95	95	CD
cord-263157-8jin6oru	247	35	)	)	-RRB-
cord-263157-8jin6oru	247	36	.	.	.
cord-263157-8jin6oru	248	1	However	however	RB
cord-263157-8jin6oru	248	2	,	,	,
cord-263157-8jin6oru	248	3	introducing	introduce	VBG
cord-263157-8jin6oru	248	4	RNAi	rnai	NN
cord-263157-8jin6oru	248	5	-	-	HYPH
cord-263157-8jin6oru	248	6	resistant	resistant	JJ
cord-263157-8jin6oru	248	7	mutations	mutation	NNS
cord-263157-8jin6oru	248	8	within	within	IN
cord-263157-8jin6oru	248	9	the	the	DT
cord-263157-8jin6oru	248	10	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	248	11	vector	vector	NN
cord-263157-8jin6oru	248	12	backbone	backbone	NN
cord-263157-8jin6oru	248	13	adds	add	VBZ
cord-263157-8jin6oru	248	14	the	the	DT
cord-263157-8jin6oru	248	15	potential	potential	JJ
cord-263157-8jin6oru	248	16	risk	risk	NN
cord-263157-8jin6oru	248	17	of	of	IN
cord-263157-8jin6oru	248	18	transfer	transfer	NN
cord-263157-8jin6oru	248	19	of	of	IN
cord-263157-8jin6oru	248	20	resistance	resistance	NN
cord-263157-8jin6oru	248	21	to	to	IN
cord-263157-8jin6oru	248	22	the	the	DT
cord-263157-8jin6oru	248	23	wild	wild	JJ
cord-263157-8jin6oru	248	24	type	type	NN
cord-263157-8jin6oru	248	25	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	248	26	genome	genome	NN
cord-263157-8jin6oru	248	27	.	.	.
cord-263157-8jin6oru	249	1	One	one	CD
cord-263157-8jin6oru	249	2	solution	solution	NN
cord-263157-8jin6oru	249	3	that	that	WDT
cord-263157-8jin6oru	249	4	has	have	VBZ
cord-263157-8jin6oru	249	5	been	be	VBN
cord-263157-8jin6oru	249	6	suggested	suggest	VBN
cord-263157-8jin6oru	249	7	would	would	MD
cord-263157-8jin6oru	249	8	be	be	VB
cord-263157-8jin6oru	249	9	to	to	TO
cord-263157-8jin6oru	249	10	incorporate	incorporate	VB
cord-263157-8jin6oru	249	11	stop	stop	VB
cord-263157-8jin6oru	249	12	codons	codon	NNS
cord-263157-8jin6oru	249	13	within	within	IN
cord-263157-8jin6oru	249	14	these	these	DT
cord-263157-8jin6oru	249	15	vector	vector	NN
cord-263157-8jin6oru	249	16	sequences	sequence	NNS
cord-263157-8jin6oru	249	17	that	that	WDT
cord-263157-8jin6oru	249	18	should	should	MD
cord-263157-8jin6oru	249	19	not	not	RB
cord-263157-8jin6oru	249	20	affect	affect	VB
cord-263157-8jin6oru	249	21	the	the	DT
cord-263157-8jin6oru	249	22	RNA	RNA	NNP
cord-263157-8jin6oru	249	23	/	/	SYM
cord-263157-8jin6oru	249	24	DNA	dna	NN
cord-263157-8jin6oru	249	25	function	function	NN
cord-263157-8jin6oru	249	26	,	,	,
cord-263157-8jin6oru	249	27	yet	yet	CC
cord-263157-8jin6oru	249	28	would	would	MD
cord-263157-8jin6oru	249	29	confer	confer	VB
cord-263157-8jin6oru	249	30	full	full	JJ
cord-263157-8jin6oru	249	31	resistance	resistance	NN
cord-263157-8jin6oru	249	32	to	to	IN
cord-263157-8jin6oru	249	33	RNAi	RNAi	NNP
cord-263157-8jin6oru	249	34	(	(	-LRB-
cord-263157-8jin6oru	249	35	96	96	CD
cord-263157-8jin6oru	249	36	)	)	-RRB-
cord-263157-8jin6oru	249	37	.	.	.
cord-263157-8jin6oru	250	1	Recombination	recombination	NN
cord-263157-8jin6oru	250	2	will	will	MD
cord-263157-8jin6oru	250	3	result	result	VB
cord-263157-8jin6oru	250	4	in	in	IN
cord-263157-8jin6oru	250	5	an	an	DT
cord-263157-8jin6oru	250	6	RNAi	rnai	NN
cord-263157-8jin6oru	250	7	-	-	HYPH
cord-263157-8jin6oru	250	8	resistant	resistant	JJ
cord-263157-8jin6oru	250	9	yet	yet	CC
cord-263157-8jin6oru	250	10	replication	replication	NN
cord-263157-8jin6oru	250	11	-	-	HYPH
cord-263157-8jin6oru	250	12	defective	defective	JJ
cord-263157-8jin6oru	250	13	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	250	14	variant	variant	NN
cord-263157-8jin6oru	250	15	due	due	IN
cord-263157-8jin6oru	250	16	to	to	IN
cord-263157-8jin6oru	250	17	the	the	DT
cord-263157-8jin6oru	250	18	stop	stop	NN
cord-263157-8jin6oru	250	19	codons	codon	NNS
cord-263157-8jin6oru	250	20	.	.	.
cord-263157-8jin6oru	251	1	Alternatively	alternatively	RB
cord-263157-8jin6oru	251	2	,	,	,
cord-263157-8jin6oru	251	3	it	-PRON-	PRP
cord-263157-8jin6oru	251	4	has	have	VBZ
cord-263157-8jin6oru	251	5	also	also	RB
cord-263157-8jin6oru	251	6	been	be	VBN
cord-263157-8jin6oru	251	7	shown	show	VBN
cord-263157-8jin6oru	251	8	that	that	IN
cord-263157-8jin6oru	251	9	the	the	DT
cord-263157-8jin6oru	251	10	incorporation	incorporation	NN
cord-263157-8jin6oru	251	11	of	of	IN
cord-263157-8jin6oru	251	12	target	target	NN
cord-263157-8jin6oru	251	13	sequences	sequence	NNS
cord-263157-8jin6oru	251	14	for	for	IN
cord-263157-8jin6oru	251	15	endogenous	endogenous	JJ
cord-263157-8jin6oru	251	16	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	251	17	within	within	IN
cord-263157-8jin6oru	251	18	the	the	DT
cord-263157-8jin6oru	251	19	lentiviral	lentiviral	NNP
cord-263157-8jin6oru	251	20	genome	genome	NN
cord-263157-8jin6oru	251	21	can	can	MD
cord-263157-8jin6oru	251	22	severely	severely	RB
cord-263157-8jin6oru	251	23	reduce	reduce	VB
cord-263157-8jin6oru	251	24	potential	potential	JJ
cord-263157-8jin6oru	251	25	recombination	recombination	NN
cord-263157-8jin6oru	251	26	or	or	CC
cord-263157-8jin6oru	251	27	mobilization	mobilization	NN
cord-263157-8jin6oru	251	28	(	(	-LRB-
cord-263157-8jin6oru	251	29	97	97	CD
cord-263157-8jin6oru	251	30	)	)	-RRB-
cord-263157-8jin6oru	251	31	.	.	.
cord-263157-8jin6oru	252	1	The	the	DT
cord-263157-8jin6oru	252	2	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	252	3	genome	genome	NN
cord-263157-8jin6oru	252	4	is	be	VBZ
cord-263157-8jin6oru	252	5	highly	highly	RB
cord-263157-8jin6oru	252	6	prone	prone	JJ
cord-263157-8jin6oru	252	7	to	to	IN
cord-263157-8jin6oru	252	8	recombination	recombination	NN
cord-263157-8jin6oru	252	9	,	,	,
cord-263157-8jin6oru	252	10	and	and	CC
cord-263157-8jin6oru	252	11	recombinants	recombinant	NNS
cord-263157-8jin6oru	252	12	arise	arise	VBP
cord-263157-8jin6oru	252	13	very	very	RB
cord-263157-8jin6oru	252	14	frequently	frequently	RB
cord-263157-8jin6oru	252	15	(	(	-LRB-
cord-263157-8jin6oru	252	16	56	56	CD
cord-263157-8jin6oru	252	17	)	)	-RRB-
cord-263157-8jin6oru	252	18	.	.	.
cord-263157-8jin6oru	253	1	Lentiviruses	Lentiviruses	NNP
cord-263157-8jin6oru	253	2	,	,	,
cord-263157-8jin6oru	253	3	unlike	unlike	IN
cord-263157-8jin6oru	253	4	murine	murine	JJ
cord-263157-8jin6oru	253	5	retroviruses	retrovirus	NNS
cord-263157-8jin6oru	253	6	,	,	,
cord-263157-8jin6oru	253	7	are	be	VBP
cord-263157-8jin6oru	253	8	more	more	RBR
cord-263157-8jin6oru	253	9	prone	prone	JJ
cord-263157-8jin6oru	253	10	to	to	TO
cord-263157-8jin6oru	253	11	integrate	integrate	VB
cord-263157-8jin6oru	253	12	distally	distally	RB
cord-263157-8jin6oru	253	13	from	from	IN
cord-263157-8jin6oru	253	14	promoters	promoter	NNS
cord-263157-8jin6oru	253	15	within	within	IN
cord-263157-8jin6oru	253	16	intron	intron	NN
cord-263157-8jin6oru	253	17	sequences	sequence	NNS
cord-263157-8jin6oru	253	18	,	,	,
cord-263157-8jin6oru	253	19	potentially	potentially	RB
cord-263157-8jin6oru	253	20	limiting	limit	VBG
cord-263157-8jin6oru	253	21	their	-PRON-	PRP$
cord-263157-8jin6oru	253	22	overall	overall	JJ
cord-263157-8jin6oru	253	23	oncogenicity	oncogenicity	NN
cord-263157-8jin6oru	253	24	(	(	-LRB-
cord-263157-8jin6oru	253	25	98	98	CD
cord-263157-8jin6oru	253	26	)	)	-RRB-
cord-263157-8jin6oru	253	27	.	.	.
cord-263157-8jin6oru	254	1	One	one	CD
cord-263157-8jin6oru	254	2	of	of	IN
cord-263157-8jin6oru	254	3	the	the	DT
cord-263157-8jin6oru	254	4	main	main	JJ
cord-263157-8jin6oru	254	5	concerns	concern	NNS
cord-263157-8jin6oru	254	6	with	with	IN
cord-263157-8jin6oru	254	7	current	current	JJ
cord-263157-8jin6oru	254	8	gene	gene	NN
cord-263157-8jin6oru	254	9	therapy	therapy	NN
cord-263157-8jin6oru	254	10	approaches	approach	NNS
cord-263157-8jin6oru	254	11	is	be	VBZ
cord-263157-8jin6oru	254	12	insertional	insertional	JJ
cord-263157-8jin6oru	254	13	mutagenesis	mutagenesis	NN
cord-263157-8jin6oru	254	14	from	from	IN
cord-263157-8jin6oru	254	15	preferential	preferential	JJ
cord-263157-8jin6oru	254	16	integration	integration	NN
cord-263157-8jin6oru	254	17	of	of	IN
cord-263157-8jin6oru	254	18	retroviral	retroviral	JJ
cord-263157-8jin6oru	254	19	vectors	vector	NNS
cord-263157-8jin6oru	254	20	into	into	IN
cord-263157-8jin6oru	254	21	actively	actively	RB
cord-263157-8jin6oru	254	22	transcribed	transcribe	VBN
cord-263157-8jin6oru	254	23	genes	gene	NNS
cord-263157-8jin6oru	254	24	,	,	,
cord-263157-8jin6oru	254	25	including	include	VBG
cord-263157-8jin6oru	254	26	proto	proto	NN
cord-263157-8jin6oru	254	27	-	-	HYPH
cord-263157-8jin6oru	254	28	oncogenes	oncogene	NNS
cord-263157-8jin6oru	254	29	.	.	.
cord-263157-8jin6oru	255	1	This	this	DT
cord-263157-8jin6oru	255	2	has	have	VBZ
cord-263157-8jin6oru	255	3	led	lead	VBN
cord-263157-8jin6oru	255	4	to	to	IN
cord-263157-8jin6oru	255	5	hematological	hematological	JJ
cord-263157-8jin6oru	255	6	malignancies	malignancy	NNS
cord-263157-8jin6oru	255	7	in	in	IN
cord-263157-8jin6oru	255	8	young	young	JJ
cord-263157-8jin6oru	255	9	individuals	individual	NNS
cord-263157-8jin6oru	255	10	with	with	IN
cord-263157-8jin6oru	255	11	severe	severe	JJ
cord-263157-8jin6oru	255	12	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	255	13	(	(	-LRB-
cord-263157-8jin6oru	255	14	SCID	SCID	NNP
cord-263157-8jin6oru	255	15	)	)	-RRB-
cord-263157-8jin6oru	255	16	disease	disease	NN
cord-263157-8jin6oru	255	17	treated	treat	VBN
cord-263157-8jin6oru	255	18	with	with	IN
cord-263157-8jin6oru	255	19	retroviral	retroviral	NN
cord-263157-8jin6oru	255	20	-	-	HYPH
cord-263157-8jin6oru	255	21	based	base	VBN
cord-263157-8jin6oru	255	22	gene	gene	NN
cord-263157-8jin6oru	255	23	therapy	therapy	NN
cord-263157-8jin6oru	255	24	(	(	-LRB-
cord-263157-8jin6oru	255	25	99	99	CD
cord-263157-8jin6oru	255	26	)	)	-RRB-
cord-263157-8jin6oru	255	27	.	.	.
cord-263157-8jin6oru	256	1	This	this	DT
cord-263157-8jin6oru	256	2	problem	problem	NN
cord-263157-8jin6oru	256	3	could	could	MD
cord-263157-8jin6oru	256	4	be	be	VB
cord-263157-8jin6oru	256	5	addressed	address	VBN
cord-263157-8jin6oru	256	6	by	by	IN
cord-263157-8jin6oru	256	7	designing	design	VBG
cord-263157-8jin6oru	256	8	vectors	vector	NNS
cord-263157-8jin6oru	256	9	that	that	WDT
cord-263157-8jin6oru	256	10	integrate	integrate	VBP
cord-263157-8jin6oru	256	11	into	into	IN
cord-263157-8jin6oru	256	12	specific	specific	JJ
cord-263157-8jin6oru	256	13	,	,	,
cord-263157-8jin6oru	256	14	well	well	RB
cord-263157-8jin6oru	256	15	-	-	HYPH
cord-263157-8jin6oru	256	16	defined	define	VBN
cord-263157-8jin6oru	256	17	regions	region	NNS
cord-263157-8jin6oru	256	18	of	of	IN
cord-263157-8jin6oru	256	19	the	the	DT
cord-263157-8jin6oru	256	20	genome	genome	NN
cord-263157-8jin6oru	256	21	.	.	.
cord-263157-8jin6oru	257	1	The	the	DT
cord-263157-8jin6oru	257	2	partially	partially	RB
cord-263157-8jin6oru	257	3	random	random	JJ
cord-263157-8jin6oru	257	4	insertion	insertion	NN
cord-263157-8jin6oru	257	5	of	of	IN
cord-263157-8jin6oru	257	6	transgenes	transgene	NNS
cord-263157-8jin6oru	257	7	into	into	IN
cord-263157-8jin6oru	257	8	chromosomal	chromosomal	JJ
cord-263157-8jin6oru	257	9	DNA	dna	NN
cord-263157-8jin6oru	257	10	of	of	IN
cord-263157-8jin6oru	257	11	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	257	12	cells	cell	NNS
cord-263157-8jin6oru	257	13	may	may	MD
cord-263157-8jin6oru	257	14	induce	induce	VB
cord-263157-8jin6oru	257	15	clonal	clonal	JJ
cord-263157-8jin6oru	257	16	competition	competition	NN
cord-263157-8jin6oru	257	17	,	,	,
cord-263157-8jin6oru	257	18	which	which	WDT
cord-263157-8jin6oru	257	19	could	could	MD
cord-263157-8jin6oru	257	20	potentially	potentially	RB
cord-263157-8jin6oru	257	21	trigger	trigger	VB
cord-263157-8jin6oru	257	22	leukemia	leukemia	NN
cord-263157-8jin6oru	257	23	or	or	CC
cord-263157-8jin6oru	257	24	sarcoma	sarcoma	NN
cord-263157-8jin6oru	257	25	(	(	-LRB-
cord-263157-8jin6oru	257	26	100	100	CD
cord-263157-8jin6oru	257	27	,	,	,
cord-263157-8jin6oru	257	28	101	101	CD
cord-263157-8jin6oru	257	29	)	)	-RRB-
cord-263157-8jin6oru	257	30	.	.	.
cord-263157-8jin6oru	258	1	Lentiviral	Lentiviral	NNP
cord-263157-8jin6oru	258	2	vectors	vector	NNS
cord-263157-8jin6oru	258	3	derived	derive	VBN
cord-263157-8jin6oru	258	4	from	from	IN
cord-263157-8jin6oru	258	5	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	258	6	,	,	,
cord-263157-8jin6oru	258	7	HIV-2	HIV-2	NNP
cord-263157-8jin6oru	258	8	/	/	SYM
cord-263157-8jin6oru	258	9	SIV	SIV	NNP
cord-263157-8jin6oru	258	10	,	,	,
cord-263157-8jin6oru	258	11	or	or	CC
cord-263157-8jin6oru	258	12	feline	feline	JJ
cord-263157-8jin6oru	258	13	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	258	14	virus	virus	NN
cord-263157-8jin6oru	258	15	(	(	-LRB-
cord-263157-8jin6oru	258	16	FIV	FIV	NNP
cord-263157-8jin6oru	258	17	)	)	-RRB-
cord-263157-8jin6oru	258	18	have	have	VBP
cord-263157-8jin6oru	258	19	been	be	VBN
cord-263157-8jin6oru	258	20	shown	show	VBN
cord-263157-8jin6oru	258	21	to	to	TO
cord-263157-8jin6oru	258	22	be	be	VB
cord-263157-8jin6oru	258	23	capable	capable	JJ
cord-263157-8jin6oru	258	24	of	of	IN
cord-263157-8jin6oru	258	25	stably	stably	RB
cord-263157-8jin6oru	258	26	transducing	transduce	VBG
cord-263157-8jin6oru	258	27	many	many	JJ
cord-263157-8jin6oru	258	28	cell	cell	NN
cord-263157-8jin6oru	258	29	types	type	NNS
cord-263157-8jin6oru	258	30	,	,	,
cord-263157-8jin6oru	258	31	including	include	VBG
cord-263157-8jin6oru	258	32	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	258	33	stem	stem	NN
cord-263157-8jin6oru	258	34	cells	cell	NNS
cord-263157-8jin6oru	258	35	(	(	-LRB-
cord-263157-8jin6oru	258	36	102	102	CD
cord-263157-8jin6oru	258	37	,	,	,
cord-263157-8jin6oru	258	38	103	103	CD
cord-263157-8jin6oru	258	39	)	)	-RRB-
cord-263157-8jin6oru	258	40	.	.	.
cord-263157-8jin6oru	259	1	Interestingly	interestingly	RB
cord-263157-8jin6oru	259	2	,	,	,
cord-263157-8jin6oru	259	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	259	4	vectors	vector	NNS
cord-263157-8jin6oru	259	5	have	have	VBP
cord-263157-8jin6oru	259	6	been	be	VBN
cord-263157-8jin6oru	259	7	shown	show	VBN
cord-263157-8jin6oru	259	8	to	to	IN
cord-263157-8jin6oru	259	9	cross	cross	JJ
cord-263157-8jin6oru	259	10	-	-	NN
cord-263157-8jin6oru	259	11	package	package	NN
cord-263157-8jin6oru	259	12	by	by	IN
cord-263157-8jin6oru	259	13	FIV	FIV	NNP
cord-263157-8jin6oru	259	14	and	and	CC
cord-263157-8jin6oru	259	15	are	be	VBP
cord-263157-8jin6oru	259	16	capable	capable	JJ
cord-263157-8jin6oru	259	17	of	of	IN
cord-263157-8jin6oru	259	18	stably	stably	RB
cord-263157-8jin6oru	259	19	transducing	transduce	VBG
cord-263157-8jin6oru	259	20	and	and	CC
cord-263157-8jin6oru	259	21	protecting	protect	VBG
cord-263157-8jin6oru	259	22	human	human	JJ
cord-263157-8jin6oru	259	23	primary	primary	JJ
cord-263157-8jin6oru	259	24	blood	blood	NN
cord-263157-8jin6oru	259	25	mononuclear	mononuclear	NN
cord-263157-8jin6oru	259	26	cells	cell	NNS
cord-263157-8jin6oru	259	27	from	from	IN
cord-263157-8jin6oru	259	28	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	259	29	infection	infection	NN
cord-263157-8jin6oru	259	30	(	(	-LRB-
cord-263157-8jin6oru	259	31	104	104	CD
cord-263157-8jin6oru	259	32	)	)	-RRB-
cord-263157-8jin6oru	259	33	.	.	.
cord-263157-8jin6oru	260	1	FIV	FIV	NNP
cord-263157-8jin6oru	260	2	packaged	package	VBD
cord-263157-8jin6oru	260	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	260	4	vectors	vector	NNS
cord-263157-8jin6oru	260	5	reduce	reduce	VBP
cord-263157-8jin6oru	260	6	the	the	DT
cord-263157-8jin6oru	260	7	likelihood	likelihood	NN
cord-263157-8jin6oru	260	8	of	of	IN
cord-263157-8jin6oru	260	9	immune	immune	JJ
cord-263157-8jin6oru	260	10	recognition	recognition	NN
cord-263157-8jin6oru	260	11	,	,	,
cord-263157-8jin6oru	260	12	or	or	CC
cord-263157-8jin6oru	260	13	seroconversion	seroconversion	NN
cord-263157-8jin6oru	260	14	,	,	,
cord-263157-8jin6oru	260	15	due	due	IN
cord-263157-8jin6oru	260	16	to	to	IN
cord-263157-8jin6oru	260	17	exposure	exposure	NN
cord-263157-8jin6oru	260	18	to	to	IN
cord-263157-8jin6oru	260	19	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	260	20	structural	structural	JJ
cord-263157-8jin6oru	260	21	proteins	protein	NNS
cord-263157-8jin6oru	260	22	.	.	.
cord-263157-8jin6oru	261	1	A	a	DT
cord-263157-8jin6oru	261	2	continuous	continuous	JJ
cord-263157-8jin6oru	261	3	effort	effort	NN
cord-263157-8jin6oru	261	4	is	be	VBZ
cord-263157-8jin6oru	261	5	focused	focus	VBN
cord-263157-8jin6oru	261	6	on	on	IN
cord-263157-8jin6oru	261	7	producing	produce	VBG
cord-263157-8jin6oru	261	8	effective	effective	JJ
cord-263157-8jin6oru	261	9	,	,	,
cord-263157-8jin6oru	261	10	safe	safe	JJ
cord-263157-8jin6oru	261	11	and	and	CC
cord-263157-8jin6oru	261	12	high	high	JJ
cord-263157-8jin6oru	261	13	-	-	HYPH
cord-263157-8jin6oru	261	14	titer	titer	NN
cord-263157-8jin6oru	261	15	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	261	16	vectors	vector	NNS
cord-263157-8jin6oru	261	17	to	to	TO
cord-263157-8jin6oru	261	18	deliver	deliver	VB
cord-263157-8jin6oru	261	19	RNAi	RNAi	NNS
cord-263157-8jin6oru	261	20	.	.	.
cord-263157-8jin6oru	262	1	Several	several	JJ
cord-263157-8jin6oru	262	2	important	important	JJ
cord-263157-8jin6oru	262	3	issues	issue	NNS
cord-263157-8jin6oru	262	4	related	relate	VBN
cord-263157-8jin6oru	262	5	to	to	IN
cord-263157-8jin6oru	262	6	in	in	IN
cord-263157-8jin6oru	262	7	vivo	vivo	NN
cord-263157-8jin6oru	262	8	safety	safety	NN
cord-263157-8jin6oru	262	9	,	,	,
cord-263157-8jin6oru	262	10	toxicity	toxicity	NN
cord-263157-8jin6oru	262	11	or	or	CC
cord-263157-8jin6oru	262	12	side	side	NN
cord-263157-8jin6oru	262	13	effects	effect	NNS
cord-263157-8jin6oru	262	14	warrant	warrant	VBP
cord-263157-8jin6oru	262	15	close	close	JJ
cord-263157-8jin6oru	262	16	attention	attention	NN
cord-263157-8jin6oru	262	17	before	before	IN
cord-263157-8jin6oru	262	18	RNAi	RNAi	NNS
cord-263157-8jin6oru	262	19	may	may	MD
cord-263157-8jin6oru	262	20	be	be	VB
cord-263157-8jin6oru	262	21	considered	consider	VBN
cord-263157-8jin6oru	262	22	a	a	DT
cord-263157-8jin6oru	262	23	valid	valid	JJ
cord-263157-8jin6oru	262	24	alternative	alternative	NN
cord-263157-8jin6oru	262	25	for	for	IN
cord-263157-8jin6oru	262	26	treating	treat	VBG
cord-263157-8jin6oru	262	27	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	262	28	infection	infection	NN
cord-263157-8jin6oru	262	29	or	or	CC
cord-263157-8jin6oru	262	30	other	other	JJ
cord-263157-8jin6oru	262	31	diseases	disease	NNS
cord-263157-8jin6oru	262	32	.	.	.
cord-263157-8jin6oru	263	1	In	in	IN
cord-263157-8jin6oru	263	2	mammalian	mammalian	JJ
cord-263157-8jin6oru	263	3	cells	cell	NNS
cord-263157-8jin6oru	263	4	,	,	,
cord-263157-8jin6oru	263	5	dsRNA	dsrna	NN
cord-263157-8jin6oru	263	6	is	be	VBZ
cord-263157-8jin6oru	263	7	recognized	recognize	VBN
cord-263157-8jin6oru	263	8	by	by	IN
cord-263157-8jin6oru	263	9	dsRNA	dsrna	NN
cord-263157-8jin6oru	263	10	sensors	sensor	NNS
cord-263157-8jin6oru	263	11	such	such	JJ
cord-263157-8jin6oru	263	12	as	as	IN
cord-263157-8jin6oru	263	13	Toll	toll	NN
cord-263157-8jin6oru	263	14	-	-	HYPH
cord-263157-8jin6oru	263	15	like	like	JJ
cord-263157-8jin6oru	263	16	receptors	receptor	NNS
cord-263157-8jin6oru	263	17	(	(	-LRB-
cord-263157-8jin6oru	263	18	TLRs	TLRs	NNP
cord-263157-8jin6oru	263	19	)	)	-RRB-
cord-263157-8jin6oru	263	20	,	,	,
cord-263157-8jin6oru	263	21	the	the	DT
cord-263157-8jin6oru	263	22	dsRNA	dsrna	JJ
cord-263157-8jin6oru	263	23	-	-	HYPH
cord-263157-8jin6oru	263	24	dependent	dependent	JJ
cord-263157-8jin6oru	263	25	protein	protein	NN
cord-263157-8jin6oru	263	26	kinase	kinase	NN
cord-263157-8jin6oru	263	27	R	r	NN
cord-263157-8jin6oru	263	28	(	(	-LRB-
cord-263157-8jin6oru	263	29	PKR	PKR	NNP
cord-263157-8jin6oru	263	30	)	)	-RRB-
cord-263157-8jin6oru	263	31	and	and	CC
cord-263157-8jin6oru	263	32	retinoic	retinoic	JJ
cord-263157-8jin6oru	263	33	-	-	HYPH
cord-263157-8jin6oru	263	34	acid	acid	NN
cord-263157-8jin6oru	263	35	-	-	HYPH
cord-263157-8jin6oru	263	36	inducible	inducible	JJ
cord-263157-8jin6oru	263	37	gene	gene	NN
cord-263157-8jin6oru	263	38	-	-	:
cord-263157-8jin6oru	263	39	I	i	NN
cord-263157-8jin6oru	263	40	(	(	-LRB-
cord-263157-8jin6oru	263	41	RIG	rig	NN
cord-263157-8jin6oru	263	42	-	-	:
cord-263157-8jin6oru	263	43	I	I	NNP
cord-263157-8jin6oru	263	44	)	)	-RRB-
cord-263157-8jin6oru	263	45	,	,	,
cord-263157-8jin6oru	263	46	which	which	WDT
cord-263157-8jin6oru	263	47	are	be	VBP
cord-263157-8jin6oru	263	48	components	component	NNS
cord-263157-8jin6oru	263	49	of	of	IN
cord-263157-8jin6oru	263	50	the	the	DT
cord-263157-8jin6oru	263	51	innate	innate	JJ
cord-263157-8jin6oru	263	52	immune	immune	JJ
cord-263157-8jin6oru	263	53	system	system	NN
cord-263157-8jin6oru	263	54	.	.	.
cord-263157-8jin6oru	264	1	This	this	DT
cord-263157-8jin6oru	264	2	recognition	recognition	NN
cord-263157-8jin6oru	264	3	leads	lead	VBZ
cord-263157-8jin6oru	264	4	to	to	IN
cord-263157-8jin6oru	264	5	the	the	DT
cord-263157-8jin6oru	264	6	activation	activation	NN
cord-263157-8jin6oru	264	7	of	of	IN
cord-263157-8jin6oru	264	8	the	the	DT
cord-263157-8jin6oru	264	9	IFN	IFN	NNP
cord-263157-8jin6oru	264	10	-	-	HYPH
cord-263157-8jin6oru	264	11	regulatory	regulatory	JJ
cord-263157-8jin6oru	264	12	transcription	transcription	NN
cord-263157-8jin6oru	264	13	factors	factor	NNS
cord-263157-8jin6oru	264	14	and	and	CC
cord-263157-8jin6oru	264	15	NF	NF	NNP
cord-263157-8jin6oru	264	16	-	-	HYPH
cord-263157-8jin6oru	264	17	kB	kB	NNP
cord-263157-8jin6oru	264	18	,	,	,
cord-263157-8jin6oru	264	19	which	which	WDT
cord-263157-8jin6oru	264	20	in	in	IN
cord-263157-8jin6oru	264	21	turn	turn	NN
cord-263157-8jin6oru	264	22	results	result	VBZ
cord-263157-8jin6oru	264	23	in	in	IN
cord-263157-8jin6oru	264	24	the	the	DT
cord-263157-8jin6oru	264	25	expression	expression	NN
cord-263157-8jin6oru	264	26	of	of	IN
cord-263157-8jin6oru	264	27	the	the	DT
cord-263157-8jin6oru	264	28	IFNs	ifn	NNS
cord-263157-8jin6oru	264	29	(	(	-LRB-
cord-263157-8jin6oru	264	30	41	41	CD
cord-263157-8jin6oru	264	31	)	)	-RRB-
cord-263157-8jin6oru	264	32	that	that	WDT
cord-263157-8jin6oru	264	33	subsequently	subsequently	RB
cord-263157-8jin6oru	264	34	activate	activate	VBP
cord-263157-8jin6oru	264	35	the	the	DT
cord-263157-8jin6oru	264	36	transcription	transcription	NN
cord-263157-8jin6oru	264	37	of	of	IN
cord-263157-8jin6oru	264	38	hundreds	hundred	NNS
cord-263157-8jin6oru	264	39	of	of	IN
cord-263157-8jin6oru	264	40	IFNstimulated	ifnstimulate	VBN
cord-263157-8jin6oru	264	41	genes	gene	NNS
cord-263157-8jin6oru	264	42	(	(	-LRB-
cord-263157-8jin6oru	264	43	ISGs	ISGs	NNP
cord-263157-8jin6oru	264	44	)	)	-RRB-
cord-263157-8jin6oru	264	45	through	through	IN
cord-263157-8jin6oru	264	46	the	the	DT
cord-263157-8jin6oru	264	47	JAK	JAK	NNP
cord-263157-8jin6oru	264	48	-	-	HYPH
cord-263157-8jin6oru	264	49	STAT	STAT	NNP
cord-263157-8jin6oru	264	50	pathway	pathway	NN
cord-263157-8jin6oru	264	51	.	.	.
cord-263157-8jin6oru	265	1	Many	many	JJ
cord-263157-8jin6oru	265	2	ISGs	isg	NNS
cord-263157-8jin6oru	265	3	encode	encode	VBP
cord-263157-8jin6oru	265	4	proteins	protein	NNS
cord-263157-8jin6oru	265	5	with	with	IN
cord-263157-8jin6oru	265	6	antiviral	antiviral	JJ
cord-263157-8jin6oru	265	7	activities	activity	NNS
cord-263157-8jin6oru	265	8	,	,	,
cord-263157-8jin6oru	265	9	including	include	VBG
cord-263157-8jin6oru	265	10	PKR	PKR	NNP
cord-263157-8jin6oru	265	11	.	.	.
cord-263157-8jin6oru	266	1	The	the	DT
cord-263157-8jin6oru	266	2	IFN	IFN	NNP
cord-263157-8jin6oru	266	3	response	response	NN
cord-263157-8jin6oru	266	4	plays	play	VBZ
cord-263157-8jin6oru	266	5	a	a	DT
cord-263157-8jin6oru	266	6	crucial	crucial	JJ
cord-263157-8jin6oru	266	7	role	role	NN
cord-263157-8jin6oru	266	8	in	in	IN
cord-263157-8jin6oru	266	9	antiviral	antiviral	JJ
cord-263157-8jin6oru	266	10	immunity	immunity	NN
cord-263157-8jin6oru	266	11	in	in	IN
cord-263157-8jin6oru	266	12	vertebrates	vertebrate	NNS
cord-263157-8jin6oru	266	13	,	,	,
cord-263157-8jin6oru	266	14	particularly	particularly	RB
cord-263157-8jin6oru	266	15	against	against	IN
cord-263157-8jin6oru	266	16	RNA	RNA	NNP
cord-263157-8jin6oru	266	17	viruses	virus	NNS
cord-263157-8jin6oru	266	18	that	that	WDT
cord-263157-8jin6oru	266	19	generate	generate	VBP
cord-263157-8jin6oru	266	20	dsRNA	dsrna	NN
cord-263157-8jin6oru	266	21	molecules	molecule	NNS
cord-263157-8jin6oru	266	22	during	during	IN
cord-263157-8jin6oru	266	23	their	-PRON-	PRP$
cord-263157-8jin6oru	266	24	life	life	NN
cord-263157-8jin6oru	266	25	cycle	cycle	NN
cord-263157-8jin6oru	266	26	.	.	.
cord-263157-8jin6oru	267	1	The	the	DT
cord-263157-8jin6oru	267	2	IFN	IFN	NNP
cord-263157-8jin6oru	267	3	response	response	NN
cord-263157-8jin6oru	267	4	could	could	MD
cord-263157-8jin6oru	267	5	significantly	significantly	RB
cord-263157-8jin6oru	267	6	influence	influence	VB
cord-263157-8jin6oru	267	7	the	the	DT
cord-263157-8jin6oru	267	8	in	in	IN
cord-263157-8jin6oru	267	9	vivo	vivo	NN
cord-263157-8jin6oru	267	10	application	application	NN
cord-263157-8jin6oru	267	11	of	of	IN
cord-263157-8jin6oru	267	12	siRNA	siRNA	NNP
cord-263157-8jin6oru	267	13	owing	owe	VBG
cord-263157-8jin6oru	267	14	to	to	IN
cord-263157-8jin6oru	267	15	the	the	DT
cord-263157-8jin6oru	267	16	off	off	JJ
cord-263157-8jin6oru	267	17	-	-	HYPH
cord-263157-8jin6oru	267	18	target	target	NN
cord-263157-8jin6oru	267	19	effects	effect	NNS
cord-263157-8jin6oru	267	20	and	and	CC
cord-263157-8jin6oru	267	21	toxicities	toxicity	NNS
cord-263157-8jin6oru	267	22	associated	associate	VBN
cord-263157-8jin6oru	267	23	with	with	IN
cord-263157-8jin6oru	267	24	immune	immune	JJ
cord-263157-8jin6oru	267	25	stimulation	stimulation	NN
cord-263157-8jin6oru	267	26	.	.	.
cord-263157-8jin6oru	268	1	siRNA	siRNA	NNP
cord-263157-8jin6oru	268	2	molecules	molecule	NNS
cord-263157-8jin6oru	268	3	less	less	JJR
cord-263157-8jin6oru	268	4	than	than	IN
cord-263157-8jin6oru	268	5	30	30	CD
cord-263157-8jin6oru	268	6	bp	bp	NN
cord-263157-8jin6oru	268	7	in	in	IN
cord-263157-8jin6oru	268	8	length	length	NN
cord-263157-8jin6oru	268	9	are	be	VBP
cord-263157-8jin6oru	268	10	generally	generally	RB
cord-263157-8jin6oru	268	11	considered	consider	VBN
cord-263157-8jin6oru	268	12	incapable	incapable	JJ
cord-263157-8jin6oru	268	13	of	of	IN
cord-263157-8jin6oru	268	14	inducing	induce	VBG
cord-263157-8jin6oru	268	15	IFN	IFN	NNP
cord-263157-8jin6oru	268	16	pathways	pathway	NNS
cord-263157-8jin6oru	268	17	(	(	-LRB-
cord-263157-8jin6oru	268	18	15	15	CD
cord-263157-8jin6oru	268	19	)	)	-RRB-
cord-263157-8jin6oru	268	20	.	.	.
cord-263157-8jin6oru	269	1	However	however	RB
cord-263157-8jin6oru	269	2	,	,	,
cord-263157-8jin6oru	269	3	synthetic	synthetic	JJ
cord-263157-8jin6oru	269	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	269	5	formulated	formulate	VBN
cord-263157-8jin6oru	269	6	in	in	IN
cord-263157-8jin6oru	269	7	non	non	JJ
cord-263157-8jin6oru	269	8	-	-	JJ
cord-263157-8jin6oru	269	9	viral	viral	JJ
cord-263157-8jin6oru	269	10	delivery	delivery	NN
cord-263157-8jin6oru	269	11	vehicles	vehicle	NNS
cord-263157-8jin6oru	269	12	can	can	MD
cord-263157-8jin6oru	269	13	be	be	VB
cord-263157-8jin6oru	269	14	potent	potent	JJ
cord-263157-8jin6oru	269	15	inducers	inducer	NNS
cord-263157-8jin6oru	269	16	of	of	IN
cord-263157-8jin6oru	269	17	IFNs	ifn	NNS
cord-263157-8jin6oru	269	18	and	and	CC
cord-263157-8jin6oru	269	19	inflammatory	inflammatory	JJ
cord-263157-8jin6oru	269	20	cytokines	cytokine	NNS
cord-263157-8jin6oru	269	21	both	both	CC
cord-263157-8jin6oru	269	22	in	in	IN
cord-263157-8jin6oru	269	23	vivo	vivo	NNP
cord-263157-8jin6oru	269	24	in	in	IN
cord-263157-8jin6oru	269	25	mouse	mouse	NN
cord-263157-8jin6oru	269	26	and	and	CC
cord-263157-8jin6oru	269	27	ex	ex	NN
cord-263157-8jin6oru	269	28	vivo	vivo	NN
cord-263157-8jin6oru	269	29	in	in	IN
cord-263157-8jin6oru	269	30	human	human	JJ
cord-263157-8jin6oru	269	31	blood	blood	NN
cord-263157-8jin6oru	269	32	cells	cell	NNS
cord-263157-8jin6oru	269	33	(	(	-LRB-
cord-263157-8jin6oru	269	34	105	105	CD
cord-263157-8jin6oru	269	35	)	)	-RRB-
cord-263157-8jin6oru	269	36	.	.	.
cord-263157-8jin6oru	270	1	The	the	DT
cord-263157-8jin6oru	270	2	immunostimulatory	immunostimulatory	NN
cord-263157-8jin6oru	270	3	activity	activity	NN
cord-263157-8jin6oru	270	4	of	of	IN
cord-263157-8jin6oru	270	5	formulated	formulate	VBN
cord-263157-8jin6oru	270	6	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	270	7	and	and	CC
cord-263157-8jin6oru	270	8	the	the	DT
cord-263157-8jin6oru	270	9	associated	associate	VBN
cord-263157-8jin6oru	270	10	toxicities	toxicity	NNS
cord-263157-8jin6oru	270	11	may	may	MD
cord-263157-8jin6oru	270	12	be	be	VB
cord-263157-8jin6oru	270	13	dependent	dependent	JJ
cord-263157-8jin6oru	270	14	on	on	IN
cord-263157-8jin6oru	270	15	the	the	DT
cord-263157-8jin6oru	270	16	nucleotide	nucleotide	JJ
cord-263157-8jin6oru	270	17	sequence	sequence	NN
cord-263157-8jin6oru	270	18	(	(	-LRB-
cord-263157-8jin6oru	270	19	106	106	CD
cord-263157-8jin6oru	270	20	)	)	-RRB-
cord-263157-8jin6oru	270	21	.	.	.
cord-263157-8jin6oru	271	1	Although	although	IN
cord-263157-8jin6oru	271	2	some	some	DT
cord-263157-8jin6oru	271	3	of	of	IN
cord-263157-8jin6oru	271	4	the	the	DT
cord-263157-8jin6oru	271	5	off	off	JJ
cord-263157-8jin6oru	271	6	-	-	HYPH
cord-263157-8jin6oru	271	7	target	target	NN
cord-263157-8jin6oru	271	8	effects	effect	NNS
cord-263157-8jin6oru	271	9	can	can	MD
cord-263157-8jin6oru	271	10	be	be	VB
cord-263157-8jin6oru	271	11	reduced	reduce	VBN
cord-263157-8jin6oru	271	12	using	use	VBG
cord-263157-8jin6oru	271	13	lower	low	JJR
cord-263157-8jin6oru	271	14	concentration	concentration	NN
cord-263157-8jin6oru	271	15	of	of	IN
cord-263157-8jin6oru	271	16	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	271	17	,	,	,
cord-263157-8jin6oru	271	18	the	the	DT
cord-263157-8jin6oru	271	19	IFN	IFN	NNP
cord-263157-8jin6oru	271	20	response	response	NN
cord-263157-8jin6oru	271	21	was	be	VBD
cord-263157-8jin6oru	271	22	observed	observe	VBN
cord-263157-8jin6oru	271	23	even	even	RB
cord-263157-8jin6oru	271	24	at	at	IN
cord-263157-8jin6oru	271	25	low	low	JJ
cord-263157-8jin6oru	271	26	concentrations	concentration	NNS
cord-263157-8jin6oru	271	27	(	(	-LRB-
cord-263157-8jin6oru	271	28	107	107	CD
cord-263157-8jin6oru	271	29	)	)	-RRB-
cord-263157-8jin6oru	271	30	.	.	.
cord-263157-8jin6oru	272	1	These	these	DT
cord-263157-8jin6oru	272	2	studies	study	NNS
cord-263157-8jin6oru	272	3	emphasize	emphasize	VBP
cord-263157-8jin6oru	272	4	the	the	DT
cord-263157-8jin6oru	272	5	relevance	relevance	NN
cord-263157-8jin6oru	272	6	of	of	IN
cord-263157-8jin6oru	272	7	examining	examine	VBG
cord-263157-8jin6oru	272	8	the	the	DT
cord-263157-8jin6oru	272	9	immunostimulatory	immunostimulatory	JJ
cord-263157-8jin6oru	272	10	effects	effect	NNS
cord-263157-8jin6oru	272	11	of	of	IN
cord-263157-8jin6oru	272	12	any	any	DT
cord-263157-8jin6oru	272	13	potential	potential	JJ
cord-263157-8jin6oru	272	14	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	272	15	siRNA	siRNA	NNP
cord-263157-8jin6oru	272	16	in	in	IN
cord-263157-8jin6oru	272	17	human	human	JJ
cord-263157-8jin6oru	272	18	immune	immune	JJ
cord-263157-8jin6oru	272	19	cells	cell	NNS
cord-263157-8jin6oru	272	20	prior	prior	RB
cord-263157-8jin6oru	272	21	to	to	IN
cord-263157-8jin6oru	272	22	clinical	clinical	JJ
cord-263157-8jin6oru	272	23	applications	application	NNS
cord-263157-8jin6oru	272	24	.	.	.
cord-263157-8jin6oru	273	1	Replacement	replacement	NN
cord-263157-8jin6oru	273	2	of	of	IN
cord-263157-8jin6oru	273	3	the	the	DT
cord-263157-8jin6oru	273	4	2	2	CD
cord-263157-8jin6oru	273	5	′	′	CD
cord-263157-8jin6oru	273	6	-hydroxyl	-hydroxyl	CD
cord-263157-8jin6oru	273	7	uridines	uridine	NNS
cord-263157-8jin6oru	273	8	with	with	IN
cord-263157-8jin6oru	273	9	either	either	DT
cord-263157-8jin6oru	273	10	2	2	CD
cord-263157-8jin6oru	273	11	′	′	CD
cord-263157-8jin6oru	273	12	-fluoro	-fluoro	NNS
cord-263157-8jin6oru	273	13	,	,	,
cord-263157-8jin6oru	273	14	or	or	CC
cord-263157-8jin6oru	273	15	2	2	CD
cord-263157-8jin6oru	273	16	′	′	CD
cord-263157-8jin6oru	273	17	-deoxy	-deoxy	CD
cord-263157-8jin6oru	273	18	or	or	CC
cord-263157-8jin6oru	273	19	2	2	CD
cord-263157-8jin6oru	273	20	′	′	CD
cord-263157-8jin6oru	273	21	-O	-o	CD
cord-263157-8jin6oru	273	22	methyl	methyl	NN
cord-263157-8jin6oru	273	23	uridines	uridine	NNS
cord-263157-8jin6oru	273	24	can	can	MD
cord-263157-8jin6oru	273	25	abrogate	abrogate	VB
cord-263157-8jin6oru	273	26	immune	immune	JJ
cord-263157-8jin6oru	273	27	recognition	recognition	NN
cord-263157-8jin6oru	273	28	of	of	IN
cord-263157-8jin6oru	273	29	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	273	30	by	by	IN
cord-263157-8jin6oru	273	31	TLRs	tlr	NNS
cord-263157-8jin6oru	273	32	without	without	IN
cord-263157-8jin6oru	273	33	compromising	compromise	VBG
cord-263157-8jin6oru	273	34	siRNA	siRNA	NNP
cord-263157-8jin6oru	273	35	silencing	silence	VBG
cord-263157-8jin6oru	273	36	potency	potency	NN
cord-263157-8jin6oru	273	37	(	(	-LRB-
cord-263157-8jin6oru	273	38	108	108	CD
cord-263157-8jin6oru	273	39	,	,	,
cord-263157-8jin6oru	273	40	109	109	CD
cord-263157-8jin6oru	273	41	,	,	,
cord-263157-8jin6oru	273	42	110	110	CD
cord-263157-8jin6oru	273	43	)	)	-RRB-
cord-263157-8jin6oru	273	44	.	.	.
cord-263157-8jin6oru	274	1	In	in	IN
cord-263157-8jin6oru	274	2	addition	addition	NN
cord-263157-8jin6oru	274	3	,	,	,
cord-263157-8jin6oru	274	4	modified	modify	VBN
cord-263157-8jin6oru	274	5	nucleotides	nucleotide	NNS
cord-263157-8jin6oru	274	6	may	may	MD
cord-263157-8jin6oru	274	7	protect	protect	VB
cord-263157-8jin6oru	274	8	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	274	9	from	from	IN
cord-263157-8jin6oru	274	10	nuclease	nuclease	NNP
cord-263157-8jin6oru	274	11	degradation	degradation	NN
cord-263157-8jin6oru	274	12	and	and	CC
cord-263157-8jin6oru	274	13	ameliorate	ameliorate	VB
cord-263157-8jin6oru	274	14	their	-PRON-	PRP$
cord-263157-8jin6oru	274	15	pharmacokinetic	pharmacokinetic	JJ
cord-263157-8jin6oru	274	16	parameters	parameter	NNS
cord-263157-8jin6oru	274	17	in	in	IN
cord-263157-8jin6oru	274	18	vivo	vivo	NN
cord-263157-8jin6oru	274	19	(	(	-LRB-
cord-263157-8jin6oru	274	20	111	111	CD
cord-263157-8jin6oru	274	21	)	)	-RRB-
cord-263157-8jin6oru	274	22	.	.	.
cord-263157-8jin6oru	275	1	Similar	similar	JJ
cord-263157-8jin6oru	275	2	to	to	TO
cord-263157-8jin6oru	275	3	synthetic	synthetic	JJ
cord-263157-8jin6oru	275	4	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	275	5	,	,	,
cord-263157-8jin6oru	275	6	endogenously	endogenously	RB
cord-263157-8jin6oru	275	7	expressed	express	VBD
cord-263157-8jin6oru	275	8	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	275	9	also	also	RB
cord-263157-8jin6oru	275	10	activated	activate	VBD
cord-263157-8jin6oru	275	11	the	the	DT
cord-263157-8jin6oru	275	12	IFN	IFN	NNP
cord-263157-8jin6oru	275	13	pathway	pathway	NN
cord-263157-8jin6oru	275	14	(	(	-LRB-
cord-263157-8jin6oru	275	15	112	112	CD
cord-263157-8jin6oru	275	16	)	)	-RRB-
cord-263157-8jin6oru	275	17	.	.	.
cord-263157-8jin6oru	276	1	Of	of	IN
cord-263157-8jin6oru	276	2	particular	particular	JJ
cord-263157-8jin6oru	276	3	concern	concern	NN
cord-263157-8jin6oru	276	4	is	be	VBZ
cord-263157-8jin6oru	276	5	the	the	DT
cord-263157-8jin6oru	276	6	development	development	NN
cord-263157-8jin6oru	276	7	of	of	IN
cord-263157-8jin6oru	276	8	a	a	DT
cord-263157-8jin6oru	276	9	multiple	multiple	JJ
cord-263157-8jin6oru	276	10	shRNA	shrna	NN
cord-263157-8jin6oru	276	11	or	or	CC
cord-263157-8jin6oru	276	12	lhRNAs	lhrnas	JJ
cord-263157-8jin6oru	276	13	approach	approach	NN
cord-263157-8jin6oru	276	14	against	against	IN
cord-263157-8jin6oru	276	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	276	16	because	because	IN
cord-263157-8jin6oru	276	17	these	these	DT
cord-263157-8jin6oru	276	18	molecules	molecule	NNS
cord-263157-8jin6oru	276	19	are	be	VBP
cord-263157-8jin6oru	276	20	longer	long	JJR
cord-263157-8jin6oru	276	21	than	than	IN
cord-263157-8jin6oru	276	22	30	30	CD
cord-263157-8jin6oru	276	23	bp	bp	NN
cord-263157-8jin6oru	276	24	.	.	.
cord-263157-8jin6oru	277	1	Endogenously	Endogenously	NNP
cord-263157-8jin6oru	277	2	(	(	-LRB-
cord-263157-8jin6oru	277	3	nuclear	nuclear	NN
cord-263157-8jin6oru	277	4	)	)	-RRB-
cord-263157-8jin6oru	277	5	expressed	express	VBD
cord-263157-8jin6oru	277	6	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	277	7	were	be	VBD
cord-263157-8jin6oru	277	8	recently	recently	RB
cord-263157-8jin6oru	277	9	shown	show	VBN
cord-263157-8jin6oru	277	10	to	to	TO
cord-263157-8jin6oru	277	11	evade	evade	VB
cord-263157-8jin6oru	277	12	detection	detection	NN
cord-263157-8jin6oru	277	13	by	by	IN
cord-263157-8jin6oru	277	14	TLRs	tlr	NNS
cord-263157-8jin6oru	277	15	,	,	,
cord-263157-8jin6oru	277	16	RIG-1	RIG-1	NNP
cord-263157-8jin6oru	277	17	and	and	CC
cord-263157-8jin6oru	277	18	PKR	PKR	NNP
cord-263157-8jin6oru	277	19	when	when	WRB
cord-263157-8jin6oru	277	20	integrated	integrate	VBN
cord-263157-8jin6oru	277	21	in	in	IN
cord-263157-8jin6oru	277	22	CD34	CD34	NNP
cord-263157-8jin6oru	277	23	+	+	CC
cord-263157-8jin6oru	277	24	progenitor	progenitor	JJ
cord-263157-8jin6oru	277	25	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	277	26	stem	stem	NN
cord-263157-8jin6oru	277	27	cells	cell	NNS
cord-263157-8jin6oru	277	28	(	(	-LRB-
cord-263157-8jin6oru	277	29	113	113	CD
cord-263157-8jin6oru	277	30	)	)	-RRB-
cord-263157-8jin6oru	277	31	.	.	.
cord-263157-8jin6oru	278	1	Endogenously	Endogenously	NNP
cord-263157-8jin6oru	278	2	expressed	express	VBD
cord-263157-8jin6oru	278	3	lhRNA	lhrna	NN
cord-263157-8jin6oru	278	4	encoding	encode	VBG
cord-263157-8jin6oru	278	5	an	an	DT
cord-263157-8jin6oru	278	6	effective	effective	JJ
cord-263157-8jin6oru	278	7	Nef	Nef	NNP
cord-263157-8jin6oru	278	8	-	-	HYPH
cord-263157-8jin6oru	278	9	specific	specific	JJ
cord-263157-8jin6oru	278	10	shRNA	shrna	NN
cord-263157-8jin6oru	278	11	was	be	VBD
cord-263157-8jin6oru	278	12	capable	capable	JJ
cord-263157-8jin6oru	278	13	of	of	IN
cord-263157-8jin6oru	278	14	inhibiting	inhibit	VBG
cord-263157-8jin6oru	278	15	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	278	16	production	production	NN
cord-263157-8jin6oru	278	17	without	without	IN
cord-263157-8jin6oru	278	18	inducing	induce	VBG
cord-263157-8jin6oru	278	19	the	the	DT
cord-263157-8jin6oru	278	20	type	type	NN
cord-263157-8jin6oru	278	21	I	-PRON-	PRP
cord-263157-8jin6oru	278	22	IFN	IFN	NNP
cord-263157-8jin6oru	278	23	genes	gene	NNS
cord-263157-8jin6oru	278	24	(	(	-LRB-
cord-263157-8jin6oru	278	25	68	68	CD
cord-263157-8jin6oru	278	26	)	)	-RRB-
cord-263157-8jin6oru	278	27	.	.	.
cord-263157-8jin6oru	279	1	Endogenously	Endogenously	NNP
cord-263157-8jin6oru	279	2	produced	produce	VBD
cord-263157-8jin6oru	279	3	dsRNA	dsrna	NN
cord-263157-8jin6oru	279	4	is	be	VBZ
cord-263157-8jin6oru	279	5	suggested	suggest	VBN
cord-263157-8jin6oru	279	6	to	to	TO
cord-263157-8jin6oru	279	7	be	be	VB
cord-263157-8jin6oru	279	8	less	less	RBR
cord-263157-8jin6oru	279	9	active	active	JJ
cord-263157-8jin6oru	279	10	than	than	IN
cord-263157-8jin6oru	279	11	exogenous	exogenous	JJ
cord-263157-8jin6oru	279	12	dsRNA	dsRNA	NNS
cord-263157-8jin6oru	279	13	in	in	IN
cord-263157-8jin6oru	279	14	inducing	induce	VBG
cord-263157-8jin6oru	279	15	the	the	DT
cord-263157-8jin6oru	279	16	IFN	IFN	NNP
cord-263157-8jin6oru	279	17	response	response	NN
cord-263157-8jin6oru	279	18	(	(	-LRB-
cord-263157-8jin6oru	279	19	114	114	CD
cord-263157-8jin6oru	279	20	)	)	-RRB-
cord-263157-8jin6oru	279	21	.	.	.
cord-263157-8jin6oru	280	1	Extended	Extended	NNP
cord-263157-8jin6oru	280	2	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	280	3	(	(	-LRB-
cord-263157-8jin6oru	280	4	e	e	LS
cord-263157-8jin6oru	280	5	-	-	NN
cord-263157-8jin6oru	280	6	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	280	7	)	)	-RRB-
cord-263157-8jin6oru	280	8	of	of	IN
cord-263157-8jin6oru	280	9	40	40	CD
cord-263157-8jin6oru	280	10	-	-	SYM
cord-263157-8jin6oru	280	11	44	44	CD
cord-263157-8jin6oru	280	12	bp	bp	NN
cord-263157-8jin6oru	280	13	that	that	WDT
cord-263157-8jin6oru	280	14	encode	encode	VBP
cord-263157-8jin6oru	280	15	two	two	CD
cord-263157-8jin6oru	280	16	effective	effective	JJ
cord-263157-8jin6oru	280	17	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	280	18	against	against	IN
cord-263157-8jin6oru	280	19	conserved	conserve	VBN
cord-263157-8jin6oru	280	20	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	280	21	sequences	sequence	NNS
cord-263157-8jin6oru	280	22	,	,	,
cord-263157-8jin6oru	280	23	Pol	Pol	NNP
cord-263157-8jin6oru	280	24	and	and	CC
cord-263157-8jin6oru	280	25	Nef	Nef	NNP
cord-263157-8jin6oru	280	26	,	,	,
cord-263157-8jin6oru	280	27	did	do	VBD
cord-263157-8jin6oru	280	28	not	not	RB
cord-263157-8jin6oru	280	29	induce	induce	VB
cord-263157-8jin6oru	280	30	the	the	DT
cord-263157-8jin6oru	280	31	IFN	IFN	NNP
cord-263157-8jin6oru	280	32	response	response	NN
cord-263157-8jin6oru	280	33	in	in	IN
cord-263157-8jin6oru	280	34	e	e	NN
cord-263157-8jin6oru	280	35	-	-	NN
cord-263157-8jin6oru	280	36	shRNA	shrna	NN
cord-263157-8jin6oru	280	37	transfected	transfecte	VBN
cord-263157-8jin6oru	280	38	293	293	CD
cord-263157-8jin6oru	280	39	T	T	NNP
cord-263157-8jin6oru	280	40	cells	cell	NNS
cord-263157-8jin6oru	280	41	(	(	-LRB-
cord-263157-8jin6oru	280	42	63	63	CD
cord-263157-8jin6oru	280	43	)	)	-RRB-
cord-263157-8jin6oru	280	44	.	.	.
cord-263157-8jin6oru	281	1	A	a	DT
cord-263157-8jin6oru	281	2	simple	simple	JJ
cord-263157-8jin6oru	281	3	strategy	strategy	NN
cord-263157-8jin6oru	281	4	for	for	IN
cord-263157-8jin6oru	281	5	avoiding	avoid	VBG
cord-263157-8jin6oru	281	6	activation	activation	NN
cord-263157-8jin6oru	281	7	of	of	IN
cord-263157-8jin6oru	281	8	the	the	DT
cord-263157-8jin6oru	281	9	IFN	IFN	NNP
cord-263157-8jin6oru	281	10	response	response	NN
cord-263157-8jin6oru	281	11	by	by	IN
cord-263157-8jin6oru	281	12	dsRNA	dsrna	NN
cord-263157-8jin6oru	281	13	has	have	VBZ
cord-263157-8jin6oru	281	14	been	be	VBN
cord-263157-8jin6oru	281	15	described	describe	VBN
cord-263157-8jin6oru	281	16	(	(	-LRB-
cord-263157-8jin6oru	281	17	67	67	CD
cord-263157-8jin6oru	281	18	)	)	-RRB-
cord-263157-8jin6oru	281	19	,	,	,
cord-263157-8jin6oru	281	20	where	where	WRB
cord-263157-8jin6oru	281	21	modified	modify	VBN
cord-263157-8jin6oru	281	22	hairpin	hairpin	NN
cord-263157-8jin6oru	281	23	-	-	HYPH
cord-263157-8jin6oru	281	24	RNAs	rna	NNS
cord-263157-8jin6oru	281	25	(	(	-LRB-
cord-263157-8jin6oru	281	26	mhRNAs	mhRNAs	NNP
cord-263157-8jin6oru	281	27	)	)	-RRB-
cord-263157-8jin6oru	281	28	of	of	IN
cord-263157-8jin6oru	281	29	more	more	JJR
cord-263157-8jin6oru	281	30	than	than	IN
cord-263157-8jin6oru	281	31	100	100	CD
cord-263157-8jin6oru	281	32	bp	bp	NNS
cord-263157-8jin6oru	281	33	with	with	IN
cord-263157-8jin6oru	281	34	multiple	multiple	JJ
cord-263157-8jin6oru	281	35	specific	specific	JJ
cord-263157-8jin6oru	281	36	point	point	NN
cord-263157-8jin6oru	281	37	-	-	HYPH
cord-263157-8jin6oru	281	38	mutations	mutation	NNS
cord-263157-8jin6oru	281	39	within	within	IN
cord-263157-8jin6oru	281	40	the	the	DT
cord-263157-8jin6oru	281	41	sense	sense	NN
cord-263157-8jin6oru	281	42	strand	strand	NN
cord-263157-8jin6oru	281	43	and	and	CC
cord-263157-8jin6oru	281	44	transcribed	transcribe	VBD
cord-263157-8jin6oru	281	45	from	from	IN
cord-263157-8jin6oru	281	46	the	the	DT
cord-263157-8jin6oru	281	47	U6	U6	NNP
cord-263157-8jin6oru	281	48	or	or	CC
cord-263157-8jin6oru	281	49	tRNA(Val	tRNA(Val	NNP
cord-263157-8jin6oru	281	50	)	)	-RRB-
cord-263157-8jin6oru	281	51	promoters	promoter	NNS
cord-263157-8jin6oru	281	52	can	can	MD
cord-263157-8jin6oru	281	53	produce	produce	VB
cord-263157-8jin6oru	281	54	RNAi	RNAi	NNS
cord-263157-8jin6oru	281	55	without	without	IN
cord-263157-8jin6oru	281	56	inducing	induce	VBG
cord-263157-8jin6oru	281	57	the	the	DT
cord-263157-8jin6oru	281	58	IFN	IFN	NNP
cord-263157-8jin6oru	281	59	pathway	pathway	NN
cord-263157-8jin6oru	281	60	genes	gene	NNS
cord-263157-8jin6oru	281	61	(	(	-LRB-
cord-263157-8jin6oru	281	62	67	67	CD
cord-263157-8jin6oru	281	63	,	,	,
cord-263157-8jin6oru	281	64	115	115	CD
cord-263157-8jin6oru	281	65	)	)	-RRB-
cord-263157-8jin6oru	281	66	.	.	.
cord-263157-8jin6oru	282	1	The	the	DT
cord-263157-8jin6oru	282	2	expression	expression	NN
cord-263157-8jin6oru	282	3	of	of	IN
cord-263157-8jin6oru	282	4	lhRNAs	lhRNAs	NNP
cord-263157-8jin6oru	282	5	also	also	RB
cord-263157-8jin6oru	282	6	appears	appear	VBZ
cord-263157-8jin6oru	282	7	to	to	TO
cord-263157-8jin6oru	282	8	be	be	VB
cord-263157-8jin6oru	282	9	well	well	RB
cord-263157-8jin6oru	282	10	tolerated	tolerate	VBN
cord-263157-8jin6oru	282	11	and	and	CC
cord-263157-8jin6oru	282	12	does	do	VBZ
cord-263157-8jin6oru	282	13	not	not	RB
cord-263157-8jin6oru	282	14	induce	induce	VB
cord-263157-8jin6oru	282	15	IFN	IFN	NNP
cord-263157-8jin6oru	282	16	gene	gene	NN
cord-263157-8jin6oru	282	17	activation	activation	NN
cord-263157-8jin6oru	282	18	in	in	IN
cord-263157-8jin6oru	282	19	vivo	vivo	NNP
cord-263157-8jin6oru	282	20	when	when	WRB
cord-263157-8jin6oru	282	21	delivered	deliver	VBN
cord-263157-8jin6oru	282	22	to	to	IN
cord-263157-8jin6oru	282	23	mice	mouse	NNS
cord-263157-8jin6oru	282	24	via	via	IN
cord-263157-8jin6oru	282	25	by	by	IN
cord-263157-8jin6oru	282	26	hydrodynamic	hydrodynamic	JJ
cord-263157-8jin6oru	282	27	tail	tail	NN
cord-263157-8jin6oru	282	28	-	-	HYPH
cord-263157-8jin6oru	282	29	vein	vein	NN
cord-263157-8jin6oru	282	30	injection	injection	NN
cord-263157-8jin6oru	282	31	(	(	-LRB-
cord-263157-8jin6oru	282	32	116	116	CD
cord-263157-8jin6oru	282	33	)	)	-RRB-
cord-263157-8jin6oru	282	34	.	.	.
cord-263157-8jin6oru	283	1	Another	another	DT
cord-263157-8jin6oru	283	2	potential	potential	JJ
cord-263157-8jin6oru	283	3	side	side	NN
cord-263157-8jin6oru	283	4	effect	effect	NN
cord-263157-8jin6oru	283	5	of	of	IN
cord-263157-8jin6oru	283	6	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	283	7	and	and	CC
cord-263157-8jin6oru	283	8	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	283	9	is	be	VBZ
cord-263157-8jin6oru	283	10	lethality	lethality	NN
cord-263157-8jin6oru	283	11	associated	associate	VBN
cord-263157-8jin6oru	283	12	with	with	IN
cord-263157-8jin6oru	283	13	overdosing	overdose	VBG
cord-263157-8jin6oru	283	14	.	.	.
cord-263157-8jin6oru	284	1	A	a	DT
cord-263157-8jin6oru	284	2	previous	previous	JJ
cord-263157-8jin6oru	284	3	study	study	NN
cord-263157-8jin6oru	284	4	in	in	IN
cord-263157-8jin6oru	284	5	which	which	WDT
cord-263157-8jin6oru	284	6	mice	mouse	NNS
cord-263157-8jin6oru	284	7	were	be	VBD
cord-263157-8jin6oru	284	8	treated	treat	VBN
cord-263157-8jin6oru	284	9	with	with	IN
cord-263157-8jin6oru	284	10	high	high	JJ
cord-263157-8jin6oru	284	11	doses	dose	NNS
cord-263157-8jin6oru	284	12	of	of	IN
cord-263157-8jin6oru	284	13	a	a	DT
cord-263157-8jin6oru	284	14	viral	viral	JJ
cord-263157-8jin6oru	284	15	vector	vector	NN
cord-263157-8jin6oru	284	16	expressing	express	VBG
cord-263157-8jin6oru	284	17	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	284	18	that	that	WDT
cord-263157-8jin6oru	284	19	resulted	result	VBD
cord-263157-8jin6oru	284	20	in	in	IN
cord-263157-8jin6oru	284	21	high	high	JJ
cord-263157-8jin6oru	284	22	copy	copy	NN
cord-263157-8jin6oru	284	23	numbers	number	NNS
cord-263157-8jin6oru	284	24	per	per	IN
cord-263157-8jin6oru	284	25	cell	cell	NN
cord-263157-8jin6oru	284	26	led	lead	VBN
cord-263157-8jin6oru	284	27	to	to	IN
cord-263157-8jin6oru	284	28	fatality	fatality	NN
cord-263157-8jin6oru	284	29	due	due	IN
cord-263157-8jin6oru	284	30	to	to	IN
cord-263157-8jin6oru	284	31	oversaturation	oversaturation	NN
cord-263157-8jin6oru	284	32	of	of	IN
cord-263157-8jin6oru	284	33	the	the	DT
cord-263157-8jin6oru	284	34	mi	mi	NNP
cord-263157-8jin6oru	284	35	/	/	SYM
cord-263157-8jin6oru	284	36	siRNA	siRNA	NNP
cord-263157-8jin6oru	284	37	pathways	pathway	NNS
cord-263157-8jin6oru	284	38	(	(	-LRB-
cord-263157-8jin6oru	284	39	65	65	CD
cord-263157-8jin6oru	284	40	)	)	-RRB-
cord-263157-8jin6oru	284	41	.	.	.
cord-263157-8jin6oru	285	1	This	this	DT
cord-263157-8jin6oru	285	2	potential	potential	JJ
cord-263157-8jin6oru	285	3	risk	risk	NN
cord-263157-8jin6oru	285	4	should	should	MD
cord-263157-8jin6oru	285	5	be	be	VB
cord-263157-8jin6oru	285	6	assessed	assess	VBN
cord-263157-8jin6oru	285	7	prior	prior	RB
cord-263157-8jin6oru	285	8	to	to	IN
cord-263157-8jin6oru	285	9	an	an	DT
cord-263157-8jin6oru	285	10	eventual	eventual	JJ
cord-263157-8jin6oru	285	11	clinical	clinical	JJ
cord-263157-8jin6oru	285	12	RNAi	rnai	NN
cord-263157-8jin6oru	285	13	application	application	NN
cord-263157-8jin6oru	285	14	.	.	.
cord-263157-8jin6oru	286	1	Cells	cell	NNS
cord-263157-8jin6oru	286	2	should	should	MD
cord-263157-8jin6oru	286	3	be	be	VB
cord-263157-8jin6oru	286	4	transduced	transduce	VBN
cord-263157-8jin6oru	286	5	with	with	IN
cord-263157-8jin6oru	286	6	few	few	JJ
cord-263157-8jin6oru	286	7	or	or	CC
cord-263157-8jin6oru	286	8	a	a	DT
cord-263157-8jin6oru	286	9	single	single	JJ
cord-263157-8jin6oru	286	10	vector	vector	NN
cord-263157-8jin6oru	286	11	copy	copy	NN
cord-263157-8jin6oru	286	12	to	to	TO
cord-263157-8jin6oru	286	13	avoid	avoid	VB
cord-263157-8jin6oru	286	14	high	high	JJ
cord-263157-8jin6oru	286	15	expression	expression	NN
cord-263157-8jin6oru	286	16	levels	level	NNS
cord-263157-8jin6oru	286	17	that	that	WDT
cord-263157-8jin6oru	286	18	may	may	MD
cord-263157-8jin6oru	286	19	induce	induce	VB
cord-263157-8jin6oru	286	20	unwanted	unwanted	JJ
cord-263157-8jin6oru	286	21	side	side	NN
cord-263157-8jin6oru	286	22	effects	effect	NNS
cord-263157-8jin6oru	286	23	.	.	.
cord-263157-8jin6oru	287	1	Overdosing	overdose	VBG
cord-263157-8jin6oru	287	2	could	could	MD
cord-263157-8jin6oru	287	3	also	also	RB
cord-263157-8jin6oru	287	4	induce	induce	VB
cord-263157-8jin6oru	287	5	off	off	IN
cord-263157-8jin6oru	287	6	-	-	HYPH
cord-263157-8jin6oru	287	7	target	target	NN
cord-263157-8jin6oru	287	8	effects	effect	NNS
cord-263157-8jin6oru	287	9	in	in	IN
cord-263157-8jin6oru	287	10	which	which	WDT
cord-263157-8jin6oru	287	11	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	287	12	or	or	CC
cord-263157-8jin6oru	287	13	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	287	14	silence	silence	NN
cord-263157-8jin6oru	287	15	partially	partially	RB
cord-263157-8jin6oru	287	16	complementary	complementary	JJ
cord-263157-8jin6oru	287	17	transcripts	transcript	NNS
cord-263157-8jin6oru	287	18	through	through	IN
cord-263157-8jin6oru	287	19	a	a	DT
cord-263157-8jin6oru	287	20	miRNA	miRNA	NNP
cord-263157-8jin6oru	287	21	-	-	HYPH
cord-263157-8jin6oru	287	22	like	like	JJ
cord-263157-8jin6oru	287	23	mechanism	mechanism	NN
cord-263157-8jin6oru	287	24	.	.	.
cord-263157-8jin6oru	288	1	Cytotoxic	cytotoxic	JJ
cord-263157-8jin6oru	288	2	effects	effect	NNS
cord-263157-8jin6oru	288	3	of	of	IN
cord-263157-8jin6oru	288	4	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	288	5	in	in	IN
cord-263157-8jin6oru	288	6	human	human	JJ
cord-263157-8jin6oru	288	7	T	t	NN
cord-263157-8jin6oru	288	8	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	288	9	as	as	IN
cord-263157-8jin6oru	288	10	a	a	DT
cord-263157-8jin6oru	288	11	result	result	NN
cord-263157-8jin6oru	288	12	of	of	IN
cord-263157-8jin6oru	288	13	overexpression	overexpression	NN
cord-263157-8jin6oru	288	14	have	have	VBP
cord-263157-8jin6oru	288	15	also	also	RB
cord-263157-8jin6oru	288	16	been	be	VBN
cord-263157-8jin6oru	288	17	reported	report	VBN
cord-263157-8jin6oru	288	18	(	(	-LRB-
cord-263157-8jin6oru	288	19	64	64	CD
cord-263157-8jin6oru	288	20	)	)	-RRB-
cord-263157-8jin6oru	288	21	.	.	.
cord-263157-8jin6oru	289	1	The	the	DT
cord-263157-8jin6oru	289	2	risk	risk	NN
cord-263157-8jin6oru	289	3	of	of	IN
cord-263157-8jin6oru	289	4	adverse	adverse	JJ
cord-263157-8jin6oru	289	5	effects	effect	NNS
cord-263157-8jin6oru	289	6	of	of	IN
cord-263157-8jin6oru	289	7	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	289	8	would	would	MD
cord-263157-8jin6oru	289	9	increase	increase	VB
cord-263157-8jin6oru	289	10	in	in	IN
cord-263157-8jin6oru	289	11	situations	situation	NNS
cord-263157-8jin6oru	289	12	where	where	WRB
cord-263157-8jin6oru	289	13	shRNA	shrna	NN
cord-263157-8jin6oru	289	14	expression	expression	NN
cord-263157-8jin6oru	289	15	is	be	VBZ
cord-263157-8jin6oru	289	16	to	to	TO
cord-263157-8jin6oru	289	17	be	be	VB
cord-263157-8jin6oru	289	18	maintained	maintain	VBN
cord-263157-8jin6oru	289	19	in	in	IN
cord-263157-8jin6oru	289	20	a	a	DT
cord-263157-8jin6oru	289	21	living	live	VBG
cord-263157-8jin6oru	289	22	organism	organism	NN
cord-263157-8jin6oru	289	23	for	for	IN
cord-263157-8jin6oru	289	24	a	a	DT
cord-263157-8jin6oru	289	25	long	long	JJ
cord-263157-8jin6oru	289	26	period	period	NN
cord-263157-8jin6oru	289	27	,	,	,
cord-263157-8jin6oru	289	28	such	such	JJ
cord-263157-8jin6oru	289	29	as	as	IN
cord-263157-8jin6oru	289	30	for	for	IN
cord-263157-8jin6oru	289	31	intracellular	intracellular	JJ
cord-263157-8jin6oru	289	32	immunization	immunization	NN
cord-263157-8jin6oru	289	33	against	against	IN
cord-263157-8jin6oru	289	34	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	289	35	.	.	.
cord-263157-8jin6oru	290	1	In	in	IN
cord-263157-8jin6oru	290	2	addition	addition	NN
cord-263157-8jin6oru	290	3	,	,	,
cord-263157-8jin6oru	290	4	transduced	transduce	VBD
cord-263157-8jin6oru	290	5	T	T	NNP
cord-263157-8jin6oru	290	6	cell	cell	NN
cord-263157-8jin6oru	290	7	lines	line	NNS
cord-263157-8jin6oru	290	8	and	and	CC
cord-263157-8jin6oru	290	9	differentiated	differentiate	VBN
cord-263157-8jin6oru	290	10	primary	primary	JJ
cord-263157-8jin6oru	290	11	human	human	JJ
cord-263157-8jin6oru	290	12	T	t	NN
cord-263157-8jin6oru	290	13	cells	cell	NNS
cord-263157-8jin6oru	290	14	are	be	VBP
cord-263157-8jin6oru	290	15	relatively	relatively	RB
cord-263157-8jin6oru	290	16	different	different	JJ
cord-263157-8jin6oru	290	17	from	from	IN
cord-263157-8jin6oru	290	18	the	the	DT
cord-263157-8jin6oru	290	19	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	290	20	CD34	CD34	NNP
cord-263157-8jin6oru	290	21	+	+	CC
cord-263157-8jin6oru	290	22	stem	stem	NN
cord-263157-8jin6oru	290	23	cells	cell	NNS
cord-263157-8jin6oru	290	24	that	that	WDT
cord-263157-8jin6oru	290	25	will	will	MD
cord-263157-8jin6oru	290	26	be	be	VB
cord-263157-8jin6oru	290	27	transduced	transduce	VBN
cord-263157-8jin6oru	290	28	in	in	IN
cord-263157-8jin6oru	290	29	an	an	DT
cord-263157-8jin6oru	290	30	ultimate	ultimate	JJ
cord-263157-8jin6oru	290	31	gene	gene	NN
cord-263157-8jin6oru	290	32	therapy	therapy	NN
cord-263157-8jin6oru	290	33	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	290	34	setting	setting	NN
cord-263157-8jin6oru	290	35	.	.	.
cord-263157-8jin6oru	291	1	Stem	stem	NN
cord-263157-8jin6oru	291	2	cells	cell	NNS
cord-263157-8jin6oru	291	3	will	will	MD
cord-263157-8jin6oru	291	4	develop	develop	VB
cord-263157-8jin6oru	291	5	into	into	IN
cord-263157-8jin6oru	291	6	different	different	JJ
cord-263157-8jin6oru	291	7	lineages	lineage	NNS
cord-263157-8jin6oru	291	8	,	,	,
cord-263157-8jin6oru	291	9	and	and	CC
cord-263157-8jin6oru	291	10	expression	expression	NN
cord-263157-8jin6oru	291	11	of	of	IN
cord-263157-8jin6oru	291	12	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	291	13	could	could	MD
cord-263157-8jin6oru	291	14	influence	influence	VB
cord-263157-8jin6oru	291	15	their	-PRON-	PRP$
cord-263157-8jin6oru	291	16	development	development	NN
cord-263157-8jin6oru	291	17	.	.	.
cord-263157-8jin6oru	292	1	As	as	IN
cord-263157-8jin6oru	292	2	suggested	suggest	VBN
cord-263157-8jin6oru	292	3	before	before	IN
cord-263157-8jin6oru	292	4	(	(	-LRB-
cord-263157-8jin6oru	292	5	96	96	CD
cord-263157-8jin6oru	292	6	)	)	-RRB-
cord-263157-8jin6oru	292	7	,	,	,
cord-263157-8jin6oru	292	8	saturation	saturation	NN
cord-263157-8jin6oru	292	9	of	of	IN
cord-263157-8jin6oru	292	10	the	the	DT
cord-263157-8jin6oru	292	11	miRNA	miRNA	NNP
cord-263157-8jin6oru	292	12	pathway	pathway	NN
cord-263157-8jin6oru	292	13	may	may	MD
cord-263157-8jin6oru	292	14	disturb	disturb	VB
cord-263157-8jin6oru	292	15	hematopoiesis	hematopoiesis	NN
cord-263157-8jin6oru	292	16	,	,	,
cord-263157-8jin6oru	292	17	and	and	CC
cord-263157-8jin6oru	292	18	indeed	indeed	RB
cord-263157-8jin6oru	292	19	,	,	,
cord-263157-8jin6oru	292	20	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	292	21	are	be	VBP
cord-263157-8jin6oru	292	22	involved	involve	VBN
cord-263157-8jin6oru	292	23	in	in	IN
cord-263157-8jin6oru	292	24	the	the	DT
cord-263157-8jin6oru	292	25	regulation	regulation	NN
cord-263157-8jin6oru	292	26	of	of	IN
cord-263157-8jin6oru	292	27	genes	gene	NNS
cord-263157-8jin6oru	292	28	that	that	WDT
cord-263157-8jin6oru	292	29	control	control	VBP
cord-263157-8jin6oru	292	30	hematopoiesis	hematopoiesis	NN
cord-263157-8jin6oru	292	31	in	in	IN
cord-263157-8jin6oru	292	32	the	the	DT
cord-263157-8jin6oru	292	33	mouse	mouse	NN
cord-263157-8jin6oru	292	34	(	(	-LRB-
cord-263157-8jin6oru	292	35	117	117	CD
cord-263157-8jin6oru	292	36	)	)	-RRB-
cord-263157-8jin6oru	292	37	.	.	.
cord-263157-8jin6oru	293	1	Whether	whether	IN
cord-263157-8jin6oru	293	2	in	in	IN
cord-263157-8jin6oru	293	3	vivo	vivo	NN
cord-263157-8jin6oru	293	4	gene	gene	NN
cord-263157-8jin6oru	293	5	silencing	silencing	NN
cord-263157-8jin6oru	293	6	by	by	IN
cord-263157-8jin6oru	293	7	siRNA	siRNA	NNP
cord-263157-8jin6oru	293	8	or	or	CC
cord-263157-8jin6oru	293	9	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	293	10	can	can	MD
cord-263157-8jin6oru	293	11	disrupt	disrupt	VB
cord-263157-8jin6oru	293	12	the	the	DT
cord-263157-8jin6oru	293	13	endogenous	endogenous	JJ
cord-263157-8jin6oru	293	14	miRNA	miRNA	NNP
cord-263157-8jin6oru	293	15	pathway	pathway	NN
cord-263157-8jin6oru	293	16	remains	remain	VBZ
cord-263157-8jin6oru	293	17	to	to	TO
cord-263157-8jin6oru	293	18	be	be	VB
cord-263157-8jin6oru	293	19	addressed	address	VBN
cord-263157-8jin6oru	293	20	.	.	.
cord-263157-8jin6oru	294	1	Recently	recently	RB
cord-263157-8jin6oru	294	2	,	,	,
cord-263157-8jin6oru	294	3	target	target	NN
cord-263157-8jin6oru	294	4	genes	gene	NNS
cord-263157-8jin6oru	294	5	were	be	VBD
cord-263157-8jin6oru	294	6	shown	show	VBN
cord-263157-8jin6oru	294	7	to	to	TO
cord-263157-8jin6oru	294	8	be	be	VB
cord-263157-8jin6oru	294	9	effectively	effectively	RB
cord-263157-8jin6oru	294	10	silenced	silence	VBN
cord-263157-8jin6oru	294	11	in	in	IN
cord-263157-8jin6oru	294	12	the	the	DT
cord-263157-8jin6oru	294	13	mouse	mouse	NN
cord-263157-8jin6oru	294	14	and	and	CC
cord-263157-8jin6oru	294	15	hamster	hamster	NN
cord-263157-8jin6oru	294	16	liver	liver	NN
cord-263157-8jin6oru	294	17	by	by	IN
cord-263157-8jin6oru	294	18	systemic	systemic	JJ
cord-263157-8jin6oru	294	19	administration	administration	NN
cord-263157-8jin6oru	294	20	of	of	IN
cord-263157-8jin6oru	294	21	synthetic	synthetic	JJ
cord-263157-8jin6oru	294	22	siRNA	siRNA	NNP
cord-263157-8jin6oru	294	23	without	without	IN
cord-263157-8jin6oru	294	24	any	any	DT
cord-263157-8jin6oru	294	25	demonstrable	demonstrable	JJ
cord-263157-8jin6oru	294	26	effect	effect	NN
cord-263157-8jin6oru	294	27	on	on	IN
cord-263157-8jin6oru	294	28	miRNA	miRNA	NNP
cord-263157-8jin6oru	294	29	levels	level	NNS
cord-263157-8jin6oru	294	30	or	or	CC
cord-263157-8jin6oru	294	31	activity	activity	NN
cord-263157-8jin6oru	294	32	(	(	-LRB-
cord-263157-8jin6oru	294	33	118	118	CD
cord-263157-8jin6oru	294	34	)	)	-RRB-
cord-263157-8jin6oru	294	35	.	.	.
cord-263157-8jin6oru	295	1	siR	siR	NNP
cord-263157-8jin6oru	295	2	-	-	HYPH
cord-263157-8jin6oru	295	3	NAs	NAs	NNPS
cord-263157-8jin6oru	295	4	targeting	target	VBG
cord-263157-8jin6oru	295	5	two	two	CD
cord-263157-8jin6oru	295	6	hepatocyte	hepatocyte	NN
cord-263157-8jin6oru	295	7	-	-	HYPH
cord-263157-8jin6oru	295	8	specific	specific	JJ
cord-263157-8jin6oru	295	9	genes	gene	NNS
cord-263157-8jin6oru	295	10	(	(	-LRB-
cord-263157-8jin6oru	295	11	apolipoprotein	apolipoprotein	NN
cord-263157-8jin6oru	295	12	B	b	NN
cord-263157-8jin6oru	295	13	and	and	CC
cord-263157-8jin6oru	295	14	factor	factor	NN
cord-263157-8jin6oru	295	15	VII	VII	NNP
cord-263157-8jin6oru	295	16	)	)	-RRB-
cord-263157-8jin6oru	295	17	were	be	VBD
cord-263157-8jin6oru	295	18	administered	administer	VBN
cord-263157-8jin6oru	295	19	to	to	IN
cord-263157-8jin6oru	295	20	mice	mouse	NNS
cord-263157-8jin6oru	295	21	and	and	CC
cord-263157-8jin6oru	295	22	achieved	achieve	VBN
cord-263157-8jin6oru	295	23	efficient	efficient	JJ
cord-263157-8jin6oru	295	24	(	(	-LRB-
cord-263157-8jin6oru	295	25	80	80	CD
cord-263157-8jin6oru	295	26	%	%	NN
cord-263157-8jin6oru	295	27	)	)	-RRB-
cord-263157-8jin6oru	295	28	silencing	silencing	NN
cord-263157-8jin6oru	295	29	of	of	IN
cord-263157-8jin6oru	295	30	mRNA	mrna	NN
cord-263157-8jin6oru	295	31	transcripts	transcript	NNS
cord-263157-8jin6oru	295	32	without	without	IN
cord-263157-8jin6oru	295	33	significant	significant	JJ
cord-263157-8jin6oru	295	34	changes	change	NNS
cord-263157-8jin6oru	295	35	in	in	IN
cord-263157-8jin6oru	295	36	the	the	DT
cord-263157-8jin6oru	295	37	levels	level	NNS
cord-263157-8jin6oru	295	38	of	of	IN
cord-263157-8jin6oru	295	39	three	three	CD
cord-263157-8jin6oru	295	40	hepatocyte	hepatocyte	NN
cord-263157-8jin6oru	295	41	-	-	HYPH
cord-263157-8jin6oru	295	42	expressed	express	VBN
cord-263157-8jin6oru	295	43	miRNAs	miRNAs	NNP
cord-263157-8jin6oru	295	44	(	(	-LRB-
cord-263157-8jin6oru	295	45	miR-122	miR-122	NNP
cord-263157-8jin6oru	295	46	,	,	,
cord-263157-8jin6oru	295	47	miR-16	miR-16	NNP
cord-263157-8jin6oru	295	48	and	and	CC
cord-263157-8jin6oru	295	49	let-7a	let-7a	NNP
cord-263157-8jin6oru	295	50	)	)	-RRB-
cord-263157-8jin6oru	296	1	(	(	-LRB-
cord-263157-8jin6oru	296	2	118	118	CD
cord-263157-8jin6oru	296	3	)	)	-RRB-
cord-263157-8jin6oru	296	4	.	.	.
cord-263157-8jin6oru	297	1	Moreover	moreover	RB
cord-263157-8jin6oru	297	2	,	,	,
cord-263157-8jin6oru	297	3	multiple	multiple	JJ
cord-263157-8jin6oru	297	4	administrations	administration	NNS
cord-263157-8jin6oru	297	5	of	of	IN
cord-263157-8jin6oru	297	6	an	an	DT
cord-263157-8jin6oru	297	7	siRNA	sirna	NN
cord-263157-8jin6oru	297	8	targeting	target	VBG
cord-263157-8jin6oru	297	9	the	the	DT
cord-263157-8jin6oru	297	10	hepatocyte	hepatocyte	NN
cord-263157-8jin6oru	297	11	-	-	HYPH
cord-263157-8jin6oru	297	12	expressed	express	VBN
cord-263157-8jin6oru	297	13	gene	gene	NN
cord-263157-8jin6oru	297	14	Scap	Scap	NNP
cord-263157-8jin6oru	297	15	in	in	IN
cord-263157-8jin6oru	297	16	hamsters	hamster	NNS
cord-263157-8jin6oru	297	17	achieved	achieve	VBD
cord-263157-8jin6oru	297	18	long	long	JJ
cord-263157-8jin6oru	297	19	-	-	HYPH
cord-263157-8jin6oru	297	20	term	term	NN
cord-263157-8jin6oru	297	21	mRNA	mrna	NN
cord-263157-8jin6oru	297	22	silencing	silence	VBG
cord-263157-8jin6oru	297	23	without	without	IN
cord-263157-8jin6oru	297	24	significant	significant	JJ
cord-263157-8jin6oru	297	25	changes	change	NNS
cord-263157-8jin6oru	297	26	in	in	IN
cord-263157-8jin6oru	297	27	miR-122	miR-122	NNP
cord-263157-8jin6oru	297	28	levels	level	NNS
cord-263157-8jin6oru	297	29	(	(	-LRB-
cord-263157-8jin6oru	297	30	118	118	CD
cord-263157-8jin6oru	297	31	)	)	-RRB-
cord-263157-8jin6oru	297	32	.	.	.
cord-263157-8jin6oru	298	1	This	this	DT
cord-263157-8jin6oru	298	2	study	study	NN
cord-263157-8jin6oru	298	3	may	may	MD
cord-263157-8jin6oru	298	4	advance	advance	VB
cord-263157-8jin6oru	298	5	the	the	DT
cord-263157-8jin6oru	298	6	use	use	NN
cord-263157-8jin6oru	298	7	of	of	IN
cord-263157-8jin6oru	298	8	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	298	9	as	as	IN
cord-263157-8jin6oru	298	10	a	a	DT
cord-263157-8jin6oru	298	11	safe	safe	JJ
cord-263157-8jin6oru	298	12	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	298	13	alternative	alternative	NN
cord-263157-8jin6oru	298	14	.	.	.
cord-263157-8jin6oru	299	1	Another	another	DT
cord-263157-8jin6oru	299	2	potential	potential	JJ
cord-263157-8jin6oru	299	3	side	side	NN
cord-263157-8jin6oru	299	4	effect	effect	NN
cord-263157-8jin6oru	299	5	for	for	IN
cord-263157-8jin6oru	299	6	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	299	7	and	and	CC
cord-263157-8jin6oru	299	8	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	299	9	is	be	VBZ
cord-263157-8jin6oru	299	10	the	the	DT
cord-263157-8jin6oru	299	11	silencing	silencing	NN
cord-263157-8jin6oru	299	12	of	of	IN
cord-263157-8jin6oru	299	13	cellular	cellular	NN
cord-263157-8jin6oru	299	14	mRNAs	mrna	NNS
cord-263157-8jin6oru	299	15	that	that	WDT
cord-263157-8jin6oru	299	16	share	share	VBP
cord-263157-8jin6oru	299	17	partial	partial	JJ
cord-263157-8jin6oru	299	18	homology	homology	NN
cord-263157-8jin6oru	299	19	to	to	IN
cord-263157-8jin6oru	299	20	the	the	DT
cord-263157-8jin6oru	299	21	siRNA	siRNA	NNP
cord-263157-8jin6oru	299	22	or	or	CC
cord-263157-8jin6oru	299	23	shRNA	shrna	NN
cord-263157-8jin6oru	299	24	sequences	sequence	NNS
cord-263157-8jin6oru	299	25	through	through	IN
cord-263157-8jin6oru	299	26	an	an	DT
cord-263157-8jin6oru	299	27	miRNA	miRNA	NNP
cord-263157-8jin6oru	299	28	-	-	HYPH
cord-263157-8jin6oru	299	29	like	like	JJ
cord-263157-8jin6oru	299	30	mechanism	mechanism	NN
cord-263157-8jin6oru	299	31	.	.	.
cord-263157-8jin6oru	300	1	This	this	DT
cord-263157-8jin6oru	300	2	off	off	IN
cord-263157-8jin6oru	300	3	-	-	HYPH
cord-263157-8jin6oru	300	4	target	target	NN
cord-263157-8jin6oru	300	5	effect	effect	NN
cord-263157-8jin6oru	300	6	requires	require	VBZ
cord-263157-8jin6oru	300	7	complementarity	complementarity	NN
cord-263157-8jin6oru	300	8	between	between	IN
cord-263157-8jin6oru	300	9	the	the	DT
cord-263157-8jin6oru	300	10	siRNA	siRNA	NNP
cord-263157-8jin6oru	300	11	seed	seed	NN
cord-263157-8jin6oru	300	12	region	region	NN
cord-263157-8jin6oru	300	13	and	and	CC
cord-263157-8jin6oru	300	14	the	the	DT
cord-263157-8jin6oru	300	15	3	3	CD
cord-263157-8jin6oru	300	16	′	′	CD
cord-263157-8jin6oru	300	17	untranslated	untranslated	JJ
cord-263157-8jin6oru	300	18	region	region	NN
cord-263157-8jin6oru	300	19	of	of	IN
cord-263157-8jin6oru	300	20	a	a	DT
cord-263157-8jin6oru	300	21	target	target	NN
cord-263157-8jin6oru	300	22	mRNA	mrna	NN
cord-263157-8jin6oru	300	23	(	(	-LRB-
cord-263157-8jin6oru	300	24	119	119	CD
cord-263157-8jin6oru	300	25	,	,	,
cord-263157-8jin6oru	300	26	121	121	CD
cord-263157-8jin6oru	300	27	,	,	,
cord-263157-8jin6oru	300	28	122	122	CD
cord-263157-8jin6oru	300	29	)	)	-RRB-
cord-263157-8jin6oru	300	30	.	.	.
cord-263157-8jin6oru	301	1	Any	any	DT
cord-263157-8jin6oru	301	2	effective	effective	JJ
cord-263157-8jin6oru	301	3	siRNA	siRNA	NNP
cord-263157-8jin6oru	301	4	or	or	CC
cord-263157-8jin6oru	301	5	shRNA	shrna	NN
cord-263157-8jin6oru	301	6	may	may	MD
cord-263157-8jin6oru	301	7	in	in	IN
cord-263157-8jin6oru	301	8	theory	theory	NN
cord-263157-8jin6oru	301	9	have	have	VBP
cord-263157-8jin6oru	301	10	numerous	numerous	JJ
cord-263157-8jin6oru	301	11	potential	potential	JJ
cord-263157-8jin6oru	301	12	off	off	NN
cord-263157-8jin6oru	301	13	-	-	HYPH
cord-263157-8jin6oru	301	14	target	target	NN
cord-263157-8jin6oru	301	15	mRNAs	mrna	NNS
cord-263157-8jin6oru	301	16	,	,	,
cord-263157-8jin6oru	301	17	thus	thus	RB
cord-263157-8jin6oru	301	18	off	off	IN
cord-263157-8jin6oru	301	19	-	-	HYPH
cord-263157-8jin6oru	301	20	target	target	NN
cord-263157-8jin6oru	301	21	silencing	silencing	NN
cord-263157-8jin6oru	301	22	may	may	MD
cord-263157-8jin6oru	301	23	not	not	RB
cord-263157-8jin6oru	301	24	be	be	VB
cord-263157-8jin6oru	301	25	easily	easily	RB
cord-263157-8jin6oru	301	26	eliminated	eliminate	VBN
cord-263157-8jin6oru	301	27	by	by	IN
cord-263157-8jin6oru	301	28	siRNA	siRNA	NNP
cord-263157-8jin6oru	301	29	sequence	sequence	NN
cord-263157-8jin6oru	301	30	selection	selection	NN
cord-263157-8jin6oru	301	31	.	.	.
cord-263157-8jin6oru	302	1	Moreover	moreover	RB
cord-263157-8jin6oru	302	2	,	,	,
cord-263157-8jin6oru	302	3	the	the	DT
cord-263157-8jin6oru	302	4	combining	combining	NN
cord-263157-8jin6oru	302	5	of	of	IN
cord-263157-8jin6oru	302	6	multiple	multiple	JJ
cord-263157-8jin6oru	302	7	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	302	8	would	would	MD
cord-263157-8jin6oru	302	9	increase	increase	VB
cord-263157-8jin6oru	302	10	the	the	DT
cord-263157-8jin6oru	302	11	number	number	NN
cord-263157-8jin6oru	302	12	of	of	IN
cord-263157-8jin6oru	302	13	off	off	IN
cord-263157-8jin6oru	302	14	-	-	HYPH
cord-263157-8jin6oru	302	15	target	target	NN
cord-263157-8jin6oru	302	16	mRNAs	mrnas	POS
cord-263157-8jin6oru	302	17	potentially	potentially	RB
cord-263157-8jin6oru	302	18	affected	affect	VBN
cord-263157-8jin6oru	302	19	.	.	.
cord-263157-8jin6oru	303	1	Off	off	IN
cord-263157-8jin6oru	303	2	-	-	HYPH
cord-263157-8jin6oru	303	3	target	target	NN
cord-263157-8jin6oru	303	4	transcript	transcript	NN
cord-263157-8jin6oru	303	5	silencing	silencing	NN
cord-263157-8jin6oru	303	6	may	may	MD
cord-263157-8jin6oru	303	7	limit	limit	VB
cord-263157-8jin6oru	303	8	the	the	DT
cord-263157-8jin6oru	303	9	specificity	specificity	NN
cord-263157-8jin6oru	303	10	of	of	IN
cord-263157-8jin6oru	303	11	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	303	12	for	for	IN
cord-263157-8jin6oru	303	13	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	303	14	applications	application	NNS
cord-263157-8jin6oru	303	15	.	.	.
cord-263157-8jin6oru	304	1	One	one	CD
cord-263157-8jin6oru	304	2	study	study	NN
cord-263157-8jin6oru	304	3	showed	show	VBD
cord-263157-8jin6oru	304	4	that	that	IN
cord-263157-8jin6oru	304	5	2	2	CD
cord-263157-8jin6oru	304	6	′	′	CD
cord-263157-8jin6oru	304	7	-uridine	-uridine	JJ
cord-263157-8jin6oru	304	8	modifications	modification	NNS
cord-263157-8jin6oru	304	9	of	of	IN
cord-263157-8jin6oru	304	10	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	304	11	can	can	MD
cord-263157-8jin6oru	304	12	reduce	reduce	VB
cord-263157-8jin6oru	304	13	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	304	14	off	off	IN
cord-263157-8jin6oru	304	15	-	-	HYPH
cord-263157-8jin6oru	304	16	target	target	NN
cord-263157-8jin6oru	304	17	effects	effect	NNS
cord-263157-8jin6oru	304	18	(	(	-LRB-
cord-263157-8jin6oru	304	19	123	123	CD
cord-263157-8jin6oru	304	20	)	)	-RRB-
cord-263157-8jin6oru	304	21	,	,	,
cord-263157-8jin6oru	304	22	and	and	CC
cord-263157-8jin6oru	304	23	similarly	similarly	RB
cord-263157-8jin6oru	304	24	,	,	,
cord-263157-8jin6oru	304	25	chemical	chemical	JJ
cord-263157-8jin6oru	304	26	modification	modification	NN
cord-263157-8jin6oru	304	27	also	also	RB
cord-263157-8jin6oru	304	28	reduced	reduce	VBD
cord-263157-8jin6oru	304	29	off	off	IN
cord-263157-8jin6oru	304	30	-	-	HYPH
cord-263157-8jin6oru	304	31	target	target	NN
cord-263157-8jin6oru	304	32	phenotypes	phenotype	NNS
cord-263157-8jin6oru	304	33	in	in	IN
cord-263157-8jin6oru	304	34	growth	growth	NN
cord-263157-8jin6oru	304	35	inhibition	inhibition	NN
cord-263157-8jin6oru	304	36	studies	study	NNS
cord-263157-8jin6oru	304	37	.	.	.
cord-263157-8jin6oru	305	1	Key	key	JJ
cord-263157-8jin6oru	305	2	to	to	IN
cord-263157-8jin6oru	305	3	the	the	DT
cord-263157-8jin6oru	305	4	modification	modification	NN
cord-263157-8jin6oru	305	5	was	be	VBD
cord-263157-8jin6oru	305	6	a	a	DT
cord-263157-8jin6oru	305	7	2	2	CD
cord-263157-8jin6oru	305	8	′	′	CD
cord-263157-8jin6oru	305	9	-O	-o	CD
cord-263157-8jin6oru	305	10	-methyl	-methyl	JJ
cord-263157-8jin6oru	305	11	ribosyl	ribosyl	JJ
cord-263157-8jin6oru	305	12	substitution	substitution	NN
cord-263157-8jin6oru	305	13	at	at	IN
cord-263157-8jin6oru	305	14	position	position	NN
cord-263157-8jin6oru	305	15	2	2	CD
cord-263157-8jin6oru	305	16	in	in	IN
cord-263157-8jin6oru	305	17	the	the	DT
cord-263157-8jin6oru	305	18	guide	guide	NN
cord-263157-8jin6oru	305	19	strand	strand	NN
cord-263157-8jin6oru	305	20	,	,	,
cord-263157-8jin6oru	305	21	which	which	WDT
cord-263157-8jin6oru	305	22	reduced	reduce	VBD
cord-263157-8jin6oru	305	23	the	the	DT
cord-263157-8jin6oru	305	24	silencing	silencing	NN
cord-263157-8jin6oru	305	25	of	of	IN
cord-263157-8jin6oru	305	26	most	most	JJS
cord-263157-8jin6oru	305	27	off	off	IN
cord-263157-8jin6oru	305	28	-	-	HYPH
cord-263157-8jin6oru	305	29	target	target	NN
cord-263157-8jin6oru	305	30	transcripts	transcript	NNS
cord-263157-8jin6oru	305	31	exhibiting	exhibit	VBG
cord-263157-8jin6oru	305	32	complementarity	complementarity	NN
cord-263157-8jin6oru	305	33	to	to	IN
cord-263157-8jin6oru	305	34	the	the	DT
cord-263157-8jin6oru	305	35	seed	seed	NN
cord-263157-8jin6oru	305	36	region	region	NN
cord-263157-8jin6oru	305	37	of	of	IN
cord-263157-8jin6oru	305	38	the	the	DT
cord-263157-8jin6oru	305	39	siRNA	siRNA	NNP
cord-263157-8jin6oru	305	40	guide	guide	NN
cord-263157-8jin6oru	305	41	strand	strand	NN
cord-263157-8jin6oru	305	42	(	(	-LRB-
cord-263157-8jin6oru	305	43	124	124	CD
cord-263157-8jin6oru	305	44	)	)	-RRB-
cord-263157-8jin6oru	305	45	.	.	.
cord-263157-8jin6oru	306	1	Ex	Ex	NNP
cord-263157-8jin6oru	306	2	vivo	vivo	NN
cord-263157-8jin6oru	306	3	selection	selection	NN
cord-263157-8jin6oru	306	4	of	of	IN
cord-263157-8jin6oru	306	5	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	306	6	to	to	TO
cord-263157-8jin6oru	306	7	verify	verify	VB
cord-263157-8jin6oru	306	8	the	the	DT
cord-263157-8jin6oru	306	9	absence	absence	NN
cord-263157-8jin6oru	306	10	of	of	IN
cord-263157-8jin6oru	306	11	unwanted	unwanted	JJ
cord-263157-8jin6oru	306	12	off	off	NN
cord-263157-8jin6oru	306	13	-	-	HYPH
cord-263157-8jin6oru	306	14	targets	target	NNS
cord-263157-8jin6oru	306	15	should	should	MD
cord-263157-8jin6oru	306	16	help	help	VB
cord-263157-8jin6oru	306	17	to	to	TO
cord-263157-8jin6oru	306	18	define	define	VB
cord-263157-8jin6oru	306	19	strategies	strategy	NNS
cord-263157-8jin6oru	306	20	to	to	TO
cord-263157-8jin6oru	306	21	either	either	CC
cord-263157-8jin6oru	306	22	enhance	enhance	VB
cord-263157-8jin6oru	306	23	or	or	CC
cord-263157-8jin6oru	306	24	avoid	avoid	VB
cord-263157-8jin6oru	306	25	the	the	DT
cord-263157-8jin6oru	306	26	non	non	JJ
cord-263157-8jin6oru	306	27	-	-	JJ
cord-263157-8jin6oru	306	28	specific	specific	JJ
cord-263157-8jin6oru	306	29	effects	effect	NNS
cord-263157-8jin6oru	306	30	of	of	IN
cord-263157-8jin6oru	306	31	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	306	32	in	in	IN
cord-263157-8jin6oru	306	33	order	order	NN
cord-263157-8jin6oru	306	34	to	to	TO
cord-263157-8jin6oru	306	35	develop	develop	VB
cord-263157-8jin6oru	306	36	safe	safe	JJ
cord-263157-8jin6oru	306	37	therapeutics	therapeutic	NNS
cord-263157-8jin6oru	306	38	.	.	.
cord-263157-8jin6oru	307	1	Studies	study	NNS
cord-263157-8jin6oru	307	2	with	with	IN
cord-263157-8jin6oru	307	3	an	an	DT
cord-263157-8jin6oru	307	4	appropriate	appropriate	JJ
cord-263157-8jin6oru	307	5	animal	animal	NN
cord-263157-8jin6oru	307	6	model	model	NN
cord-263157-8jin6oru	307	7	should	should	MD
cord-263157-8jin6oru	307	8	also	also	RB
cord-263157-8jin6oru	307	9	help	help	VB
cord-263157-8jin6oru	307	10	preclinical	preclinical	JJ
cord-263157-8jin6oru	307	11	assessment	assessment	NN
cord-263157-8jin6oru	307	12	of	of	IN
cord-263157-8jin6oru	307	13	safety	safety	NN
cord-263157-8jin6oru	307	14	and	and	CC
cord-263157-8jin6oru	307	15	efficacy	efficacy	NN
cord-263157-8jin6oru	307	16	.	.	.
cord-263157-8jin6oru	308	1	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	308	2	research	research	NN
cord-263157-8jin6oru	308	3	is	be	VBZ
cord-263157-8jin6oru	308	4	largely	largely	RB
cord-263157-8jin6oru	308	5	restricted	restrict	VBN
cord-263157-8jin6oru	308	6	to	to	IN
cord-263157-8jin6oru	308	7	in	in	FW
cord-263157-8jin6oru	308	8	vitro	vitro	FW
cord-263157-8jin6oru	308	9	,	,	,
cord-263157-8jin6oru	308	10	ex	ex	NN
cord-263157-8jin6oru	308	11	vivo	vivo	NN
cord-263157-8jin6oru	308	12	or	or	CC
cord-263157-8jin6oru	308	13	clinical	clinical	JJ
cord-263157-8jin6oru	308	14	studies	study	NNS
cord-263157-8jin6oru	308	15	,	,	,
cord-263157-8jin6oru	308	16	all	all	DT
cord-263157-8jin6oru	308	17	limited	limit	VBN
cord-263157-8jin6oru	308	18	in	in	IN
cord-263157-8jin6oru	308	19	their	-PRON-	PRP$
cord-263157-8jin6oru	308	20	ability	ability	NN
cord-263157-8jin6oru	308	21	to	to	TO
cord-263157-8jin6oru	308	22	rapidly	rapidly	RB
cord-263157-8jin6oru	308	23	assess	assess	VB
cord-263157-8jin6oru	308	24	new	new	JJ
cord-263157-8jin6oru	308	25	strategies	strategy	NNS
cord-263157-8jin6oru	308	26	to	to	TO
cord-263157-8jin6oru	308	27	treat	treat	VB
cord-263157-8jin6oru	308	28	virus	virus	NN
cord-263157-8jin6oru	308	29	infection	infection	NN
cord-263157-8jin6oru	308	30	.	.	.
cord-263157-8jin6oru	309	1	The	the	DT
cord-263157-8jin6oru	309	2	humanized	humanized	JJ
cord-263157-8jin6oru	309	3	Rag2(−/−	Rag2(−/−	NNS
cord-263157-8jin6oru	309	4	)	)	-RRB-
cord-263157-8jin6oru	309	5	gammac(−/−	gammac(−/−	ADD
cord-263157-8jin6oru	309	6	)	)	-RRB-
cord-263157-8jin6oru	310	1	SCID	SCID	NNP
cord-263157-8jin6oru	310	2	mouse	mouse	NN
cord-263157-8jin6oru	310	3	model	model	NN
cord-263157-8jin6oru	310	4	sustains	sustain	VBZ
cord-263157-8jin6oru	310	5	long	long	JJ
cord-263157-8jin6oru	310	6	-	-	HYPH
cord-263157-8jin6oru	310	7	term	term	NN
cord-263157-8jin6oru	310	8	multi	multi	JJ
cord-263157-8jin6oru	310	9	-	-	JJ
cord-263157-8jin6oru	310	10	lineage	lineage	JJ
cord-263157-8jin6oru	310	11	hematopoiesis	hematopoiesis	NN
cord-263157-8jin6oru	310	12	and	and	CC
cord-263157-8jin6oru	310	13	is	be	VBZ
cord-263157-8jin6oru	310	14	capable	capable	JJ
cord-263157-8jin6oru	310	15	of	of	IN
cord-263157-8jin6oru	310	16	mounting	mount	VBG
cord-263157-8jin6oru	310	17	immune	immune	JJ
cord-263157-8jin6oru	310	18	responses	response	NNS
cord-263157-8jin6oru	310	19	,	,	,
cord-263157-8jin6oru	310	20	achieved	achieve	VBN
cord-263157-8jin6oru	310	21	by	by	IN
cord-263157-8jin6oru	310	22	the	the	DT
cord-263157-8jin6oru	310	23	intraperitoneal	intraperitoneal	JJ
cord-263157-8jin6oru	310	24	injection	injection	NN
cord-263157-8jin6oru	310	25	of	of	IN
cord-263157-8jin6oru	310	26	CD34	CD34	NNP
cord-263157-8jin6oru	310	27	+	+	CC
cord-263157-8jin6oru	310	28	precursor	precursor	NN
cord-263157-8jin6oru	310	29	cells	cell	NNS
cord-263157-8jin6oru	310	30	into	into	IN
cord-263157-8jin6oru	310	31	a	a	DT
cord-263157-8jin6oru	310	32	newborn	newborn	JJ
cord-263157-8jin6oru	310	33	Rag2(−/−	Rag2(−/−	NNS
cord-263157-8jin6oru	310	34	)	)	-RRB-
cord-263157-8jin6oru	310	35	gammac(−/−	gammac(−/−	ADD
cord-263157-8jin6oru	310	36	)	)	-RRB-
cord-263157-8jin6oru	310	37	mouse	mouse	NN
cord-263157-8jin6oru	310	38	(	(	-LRB-
cord-263157-8jin6oru	310	39	125	125	CD
cord-263157-8jin6oru	310	40	,	,	,
cord-263157-8jin6oru	310	41	126	126	CD
cord-263157-8jin6oru	310	42	)	)	-RRB-
cord-263157-8jin6oru	310	43	.	.	.
cord-263157-8jin6oru	311	1	In	in	IN
cord-263157-8jin6oru	311	2	this	this	DT
cord-263157-8jin6oru	311	3	model	model	NN
cord-263157-8jin6oru	311	4	,	,	,
cord-263157-8jin6oru	311	5	injecting	inject	VBG
cord-263157-8jin6oru	311	6	p53	p53	NN
cord-263157-8jin6oru	311	7	shRNA	shrna	RB
cord-263157-8jin6oru	311	8	-	-	HYPH
cord-263157-8jin6oru	311	9	transduced	transduce	VBN
cord-263157-8jin6oru	311	10	CD34	CD34	NNP
cord-263157-8jin6oru	311	11	+	+	CC
cord-263157-8jin6oru	311	12	cells	cell	NNS
cord-263157-8jin6oru	311	13	resulted	result	VBD
cord-263157-8jin6oru	311	14	in	in	IN
cord-263157-8jin6oru	311	15	stable	stable	JJ
cord-263157-8jin6oru	311	16	expression	expression	NN
cord-263157-8jin6oru	311	17	and	and	CC
cord-263157-8jin6oru	311	18	down	down	JJ
cord-263157-8jin6oru	311	19	-	-	HYPH
cord-263157-8jin6oru	311	20	modulation	modulation	NN
cord-263157-8jin6oru	311	21	of	of	IN
cord-263157-8jin6oru	311	22	p53	p53	NN
cord-263157-8jin6oru	311	23	in	in	IN
cord-263157-8jin6oru	311	24	the	the	DT
cord-263157-8jin6oru	311	25	mature	mature	JJ
cord-263157-8jin6oru	311	26	T	t	NN
cord-263157-8jin6oru	311	27	-	-	HYPH
cord-263157-8jin6oru	311	28	cell	cell	NN
cord-263157-8jin6oru	311	29	offspring	offspring	NN
cord-263157-8jin6oru	311	30	.	.	.
cord-263157-8jin6oru	312	1	Infection	infection	NN
cord-263157-8jin6oru	312	2	of	of	IN
cord-263157-8jin6oru	312	3	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	312	4	in	in	IN
cord-263157-8jin6oru	312	5	this	this	DT
cord-263157-8jin6oru	312	6	mouse	mouse	NN
cord-263157-8jin6oru	312	7	model	model	NN
cord-263157-8jin6oru	312	8	resulted	result	VBD
cord-263157-8jin6oru	312	9	in	in	IN
cord-263157-8jin6oru	312	10	high	high	JJ
cord-263157-8jin6oru	312	11	viremia	viremia	NN
cord-263157-8jin6oru	312	12	and	and	CC
cord-263157-8jin6oru	312	13	CD4	CD4	NNP
cord-263157-8jin6oru	312	14	+	+	CC
cord-263157-8jin6oru	312	15	T	t	NN
cord-263157-8jin6oru	312	16	cell	cell	NN
cord-263157-8jin6oru	312	17	depletion	depletion	NN
cord-263157-8jin6oru	312	18	(	(	-LRB-
cord-263157-8jin6oru	312	19	127	127	CD
cord-263157-8jin6oru	312	20	)	)	-RRB-
cord-263157-8jin6oru	312	21	.	.	.
cord-263157-8jin6oru	313	1	Therefore	therefore	RB
cord-263157-8jin6oru	313	2	,	,	,
cord-263157-8jin6oru	313	3	this	this	DT
cord-263157-8jin6oru	313	4	in	in	IN
cord-263157-8jin6oru	313	5	vivo	vivo	NNP
cord-263157-8jin6oru	313	6	animal	animal	NN
cord-263157-8jin6oru	313	7	model	model	NN
cord-263157-8jin6oru	313	8	and/or	and/or	CC
cord-263157-8jin6oru	313	9	others	other	NNS
cord-263157-8jin6oru	313	10	developed	develop	VBN
cord-263157-8jin6oru	313	11	in	in	IN
cord-263157-8jin6oru	313	12	the	the	DT
cord-263157-8jin6oru	313	13	near	near	JJ
cord-263157-8jin6oru	313	14	future	future	NN
cord-263157-8jin6oru	313	15	should	should	MD
cord-263157-8jin6oru	313	16	be	be	VB
cord-263157-8jin6oru	313	17	valuable	valuable	JJ
cord-263157-8jin6oru	313	18	to	to	TO
cord-263157-8jin6oru	313	19	evaluate	evaluate	VB
cord-263157-8jin6oru	313	20	RNAi	RNAi	NNP
cord-263157-8jin6oru	313	21	-	-	HYPH
cord-263157-8jin6oru	313	22	based	base	VBN
cord-263157-8jin6oru	313	23	strategies	strategy	NNS
cord-263157-8jin6oru	313	24	aiming	aim	VBG
cord-263157-8jin6oru	313	25	to	to	TO
cord-263157-8jin6oru	313	26	prevent	prevent	VB
cord-263157-8jin6oru	313	27	or	or	CC
cord-263157-8jin6oru	313	28	treat	treat	VB
cord-263157-8jin6oru	313	29	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	313	30	infection	infection	NN
cord-263157-8jin6oru	313	31	.	.	.
cord-263157-8jin6oru	314	1	The	the	DT
cord-263157-8jin6oru	314	2	discovery	discovery	NN
cord-263157-8jin6oru	314	3	of	of	IN
cord-263157-8jin6oru	314	4	RNAi	RNAi	NNP
cord-263157-8jin6oru	314	5	has	have	VBZ
cord-263157-8jin6oru	314	6	provided	provide	VBN
cord-263157-8jin6oru	314	7	us	-PRON-	PRP
cord-263157-8jin6oru	314	8	with	with	IN
cord-263157-8jin6oru	314	9	powerful	powerful	JJ
cord-263157-8jin6oru	314	10	new	new	JJ
cord-263157-8jin6oru	314	11	tools	tool	NNS
cord-263157-8jin6oru	314	12	for	for	IN
cord-263157-8jin6oru	314	13	biological	biological	JJ
cord-263157-8jin6oru	314	14	research	research	NN
cord-263157-8jin6oru	314	15	and	and	CC
cord-263157-8jin6oru	314	16	drug	drug	NN
cord-263157-8jin6oru	314	17	discovery	discovery	NN
cord-263157-8jin6oru	314	18	,	,	,
cord-263157-8jin6oru	314	19	and	and	CC
cord-263157-8jin6oru	314	20	RNAi	RNAi	NNP
cord-263157-8jin6oru	314	21	is	be	VBZ
cord-263157-8jin6oru	314	22	currently	currently	RB
cord-263157-8jin6oru	314	23	advancing	advance	VBG
cord-263157-8jin6oru	314	24	from	from	IN
cord-263157-8jin6oru	314	25	basic	basic	JJ
cord-263157-8jin6oru	314	26	research	research	NN
cord-263157-8jin6oru	314	27	to	to	IN
cord-263157-8jin6oru	314	28	clinical	clinical	JJ
cord-263157-8jin6oru	314	29	trials	trial	NNS
cord-263157-8jin6oru	314	30	.	.	.
cord-263157-8jin6oru	315	1	It	-PRON-	PRP
cord-263157-8jin6oru	315	2	has	have	VBZ
cord-263157-8jin6oru	315	3	also	also	RB
cord-263157-8jin6oru	315	4	expanded	expand	VBN
cord-263157-8jin6oru	315	5	the	the	DT
cord-263157-8jin6oru	315	6	direction	direction	NN
cord-263157-8jin6oru	315	7	of	of	IN
cord-263157-8jin6oru	315	8	a	a	DT
cord-263157-8jin6oru	315	9	new	new	JJ
cord-263157-8jin6oru	315	10	field	field	NN
cord-263157-8jin6oru	315	11	of	of	IN
cord-263157-8jin6oru	315	12	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	315	13	strategies	strategy	NNS
cord-263157-8jin6oru	315	14	with	with	IN
cord-263157-8jin6oru	315	15	the	the	DT
cord-263157-8jin6oru	315	16	potential	potential	NN
cord-263157-8jin6oru	315	17	to	to	TO
cord-263157-8jin6oru	315	18	treat	treat	VB
cord-263157-8jin6oru	315	19	a	a	DT
cord-263157-8jin6oru	315	20	wide	wide	JJ
cord-263157-8jin6oru	315	21	range	range	NN
cord-263157-8jin6oru	315	22	of	of	IN
cord-263157-8jin6oru	315	23	different	different	JJ
cord-263157-8jin6oru	315	24	diseases	disease	NNS
cord-263157-8jin6oru	315	25	,	,	,
cord-263157-8jin6oru	315	26	including	include	VBG
cord-263157-8jin6oru	315	27	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	315	28	.	.	.
cord-263157-8jin6oru	316	1	Several	several	JJ
cord-263157-8jin6oru	316	2	decades	decade	NNS
cord-263157-8jin6oru	316	3	ago	ago	RB
cord-263157-8jin6oru	316	4	,	,	,
cord-263157-8jin6oru	316	5	adaptive	adaptive	JJ
cord-263157-8jin6oru	316	6	immunity	immunity	NN
cord-263157-8jin6oru	316	7	allowed	allow	VBD
cord-263157-8jin6oru	316	8	the	the	DT
cord-263157-8jin6oru	316	9	possibility	possibility	NN
cord-263157-8jin6oru	316	10	of	of	IN
cord-263157-8jin6oru	316	11	preventing	prevent	VBG
cord-263157-8jin6oru	316	12	the	the	DT
cord-263157-8jin6oru	316	13	spread	spread	NN
cord-263157-8jin6oru	316	14	of	of	IN
cord-263157-8jin6oru	316	15	many	many	JJ
cord-263157-8jin6oru	316	16	pathogenic	pathogenic	JJ
cord-263157-8jin6oru	316	17	human	human	JJ
cord-263157-8jin6oru	316	18	viruses	virus	NNS
cord-263157-8jin6oru	316	19	.	.	.
cord-263157-8jin6oru	317	1	Nevertheless	nevertheless	RB
cord-263157-8jin6oru	317	2	,	,	,
cord-263157-8jin6oru	317	3	the	the	DT
cord-263157-8jin6oru	317	4	discovery	discovery	NN
cord-263157-8jin6oru	317	5	of	of	IN
cord-263157-8jin6oru	317	6	an	an	DT
cord-263157-8jin6oru	317	7	effective	effective	JJ
cord-263157-8jin6oru	317	8	preventive	preventive	JJ
cord-263157-8jin6oru	317	9	or	or	CC
cord-263157-8jin6oru	317	10	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	317	11	vaccine	vaccine	NN
cord-263157-8jin6oru	317	12	against	against	IN
cord-263157-8jin6oru	317	13	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	317	14	remains	remain	VBZ
cord-263157-8jin6oru	317	15	elusive	elusive	JJ
cord-263157-8jin6oru	317	16	.	.	.
cord-263157-8jin6oru	318	1	RNAi	RNAi	NNP
cord-263157-8jin6oru	318	2	therapeutics	therapeutics	NNP
cord-263157-8jin6oru	318	3	is	be	VBZ
cord-263157-8jin6oru	318	4	rapidly	rapidly	RB
cord-263157-8jin6oru	318	5	arriving	arrive	VBG
cord-263157-8jin6oru	318	6	into	into	IN
cord-263157-8jin6oru	318	7	clinical	clinical	JJ
cord-263157-8jin6oru	318	8	studies	study	NNS
cord-263157-8jin6oru	318	9	for	for	IN
cord-263157-8jin6oru	318	10	many	many	JJ
cord-263157-8jin6oru	318	11	diseases	disease	NNS
cord-263157-8jin6oru	318	12	,	,	,
cord-263157-8jin6oru	318	13	including	include	VBG
cord-263157-8jin6oru	318	14	several	several	JJ
cord-263157-8jin6oru	318	15	which	which	WDT
cord-263157-8jin6oru	318	16	are	be	VBP
cord-263157-8jin6oru	318	17	currently	currently	RB
cord-263157-8jin6oru	318	18	untreatable	untreatable	JJ
cord-263157-8jin6oru	318	19	or	or	CC
cord-263157-8jin6oru	318	20	difficult	difficult	JJ
cord-263157-8jin6oru	318	21	to	to	TO
cord-263157-8jin6oru	318	22	treat	treat	VB
cord-263157-8jin6oru	318	23	with	with	IN
cord-263157-8jin6oru	318	24	conventional	conventional	JJ
cord-263157-8jin6oru	318	25	drugs	drug	NNS
cord-263157-8jin6oru	318	26	.	.	.
cord-263157-8jin6oru	319	1	Although	although	IN
cord-263157-8jin6oru	319	2	promising	promising	JJ
cord-263157-8jin6oru	319	3	studies	study	NNS
cord-263157-8jin6oru	319	4	and	and	CC
cord-263157-8jin6oru	319	5	results	result	NNS
cord-263157-8jin6oru	319	6	have	have	VBP
cord-263157-8jin6oru	319	7	emerged	emerge	VBN
cord-263157-8jin6oru	319	8	over	over	IN
cord-263157-8jin6oru	319	9	the	the	DT
cord-263157-8jin6oru	319	10	recent	recent	JJ
cord-263157-8jin6oru	319	11	years	year	NNS
cord-263157-8jin6oru	319	12	,	,	,
cord-263157-8jin6oru	319	13	the	the	DT
cord-263157-8jin6oru	319	14	challenge	challenge	NN
cord-263157-8jin6oru	319	15	remains	remain	VBZ
cord-263157-8jin6oru	319	16	as	as	IN
cord-263157-8jin6oru	319	17	to	to	IN
cord-263157-8jin6oru	319	18	whether	whether	IN
cord-263157-8jin6oru	319	19	RNAi	RNAi	NNS
cord-263157-8jin6oru	319	20	will	will	MD
cord-263157-8jin6oru	319	21	be	be	VB
cord-263157-8jin6oru	319	22	suitable	suitable	JJ
cord-263157-8jin6oru	319	23	for	for	IN
cord-263157-8jin6oru	319	24	treating	treat	VBG
cord-263157-8jin6oru	319	25	or	or	CC
cord-263157-8jin6oru	319	26	preventing	prevent	VBG
cord-263157-8jin6oru	319	27	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	319	28	infection	infection	NN
cord-263157-8jin6oru	319	29	.	.	.
cord-263157-8jin6oru	320	1	MAM	MAM	NNP
cord-263157-8jin6oru	320	2	is	be	VBZ
cord-263157-8jin6oru	320	3	supported	support	VBN
cord-263157-8jin6oru	320	4	by	by	IN
cord-263157-8jin6oru	320	5	the	the	DT
cord-263157-8jin6oru	320	6	Spanish	Spanish	NNP
cord-263157-8jin6oru	320	7	Minsiterio	Minsiterio	NNP
cord-263157-8jin6oru	320	8	de	de	NNP
cord-263157-8jin6oru	320	9	Educación	Educación	NNP
cord-263157-8jin6oru	320	10	y	y	NNP
cord-263157-8jin6oru	320	11	Ciencia	Ciencia	NNP
cord-263157-8jin6oru	320	12	(	(	-LRB-
cord-263157-8jin6oru	320	13	MEC	MEC	NNP
cord-263157-8jin6oru	320	14	)	)	-RRB-
cord-263157-8jin6oru	320	15	project	project	NN
cord-263157-8jin6oru	320	16	BFU2006	BFU2006	NNP
cord-263157-8jin6oru	320	17	-	-	HYPH
cord-263157-8jin6oru	320	18	01066	01066	CD
cord-263157-8jin6oru	321	1	/BMC	/BMC	NNP
cord-263157-8jin6oru	321	2	,	,	,
cord-263157-8jin6oru	321	3	Fondo	Fondo	NNP
cord-263157-8jin6oru	321	4	de	de	NNP
cord-263157-8jin6oru	321	5	Investigación	Investigación	NNP
cord-263157-8jin6oru	321	6	Sanitaria	Sanitaria	NNP
cord-263157-8jin6oru	321	7	(	(	-LRB-
cord-263157-8jin6oru	321	8	FIS	FIS	NNP
cord-263157-8jin6oru	321	9	)	)	-RRB-
cord-263157-8jin6oru	321	10	project	project	NN
cord-263157-8jin6oru	321	11	PI070098	pi070098	NN
cord-263157-8jin6oru	321	12	,	,	,
cord-263157-8jin6oru	321	13	and	and	CC
cord-263157-8jin6oru	321	14	Fundación	Fundación	NNP
cord-263157-8jin6oru	321	15	para	para	NNP
cord-263157-8jin6oru	321	16	la	la	NNP
cord-263157-8jin6oru	321	17	investigación	investigación	NNP
cord-263157-8jin6oru	321	18	y	y	NNP
cord-263157-8jin6oru	321	19	la	la	NNP
cord-263157-8jin6oru	321	20	prevención	prevención	NNP
cord-263157-8jin6oru	321	21	del	del	FW
cord-263157-8jin6oru	321	22	SIDA	SIDA	NNP
cord-263157-8jin6oru	321	23	en	en	FW
cord-263157-8jin6oru	321	24	España	España	NNP
cord-263157-8jin6oru	321	25	(	(	-LRB-
cord-263157-8jin6oru	321	26	FIPSE	FIPSE	NNP
cord-263157-8jin6oru	321	27	36549/06	36549/06	CD
cord-263157-8jin6oru	321	28	)	)	-RRB-
cord-263157-8jin6oru	321	29	.	.	.
cord-263157-8jin6oru	322	1	siRNA	siRNA	NNP
cord-263157-8jin6oru	322	2	-	-	HYPH
cord-263157-8jin6oru	322	3	directed	direct	VBN
cord-263157-8jin6oru	322	4	inhibition	inhibition	NN
cord-263157-8jin6oru	322	5	of	of	IN
cord-263157-8jin6oru	322	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	322	7	infection	infection	NN
cord-263157-8jin6oru	322	8	Modulation	modulation	NN
cord-263157-8jin6oru	322	9	of	of	IN
cord-263157-8jin6oru	322	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	322	11	replication	replication	NN
cord-263157-8jin6oru	322	12	by	by	IN
cord-263157-8jin6oru	322	13	RNA	RNA	NNP
cord-263157-8jin6oru	322	14	interference	interference	NN
cord-263157-8jin6oru	322	15	Potent	potent	JJ
cord-263157-8jin6oru	322	16	and	and	CC
cord-263157-8jin6oru	322	17	specific	specific	JJ
cord-263157-8jin6oru	322	18	inhibition	inhibition	NN
cord-263157-8jin6oru	322	19	of	of	IN
cord-263157-8jin6oru	322	20	human	human	JJ
cord-263157-8jin6oru	322	21	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	322	22	virus	virus	NN
cord-263157-8jin6oru	322	23	type	type	NN
cord-263157-8jin6oru	322	24	1	1	CD
cord-263157-8jin6oru	322	25	replication	replication	NN
cord-263157-8jin6oru	322	26	by	by	IN
cord-263157-8jin6oru	322	27	RNA	RNA	NNP
cord-263157-8jin6oru	322	28	interference	interference	NN
cord-263157-8jin6oru	322	29	Inhibition	inhibition	NN
cord-263157-8jin6oru	322	30	of	of	IN
cord-263157-8jin6oru	322	31	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	322	32	infection	infection	NN
cord-263157-8jin6oru	322	33	by	by	IN
cord-263157-8jin6oru	322	34	small	small	JJ
cord-263157-8jin6oru	322	35	interfering	interfere	VBG
cord-263157-8jin6oru	322	36	RNA	RNA	NNP
cord-263157-8jin6oru	322	37	-	-	HYPH
cord-263157-8jin6oru	322	38	mediated	mediate	VBN
cord-263157-8jin6oru	322	39	RNA	RNA	NNP
cord-263157-8jin6oru	322	40	interference	interference	NN
cord-263157-8jin6oru	322	41	Prevention	Prevention	NNP
cord-263157-8jin6oru	322	42	of	of	IN
cord-263157-8jin6oru	322	43	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	322	44	infection	infection	NN
cord-263157-8jin6oru	322	45	in	in	IN
cord-263157-8jin6oru	322	46	human	human	JJ
cord-263157-8jin6oru	322	47	peripheral	peripheral	JJ
cord-263157-8jin6oru	322	48	blood	blood	NN
cord-263157-8jin6oru	322	49	mononuclear	mononuclear	NN
cord-263157-8jin6oru	322	50	cells	cell	NNS
cord-263157-8jin6oru	322	51	by	by	IN
cord-263157-8jin6oru	322	52	specific	specific	JJ
cord-263157-8jin6oru	322	53	RNA	RNA	NNP
cord-263157-8jin6oru	322	54	interference	interference	NN
cord-263157-8jin6oru	322	55	RNA	RNA	NNP
cord-263157-8jin6oru	322	56	interference	interference	NN
cord-263157-8jin6oru	322	57	directed	direct	VBN
cord-263157-8jin6oru	322	58	against	against	IN
cord-263157-8jin6oru	322	59	viral	viral	JJ
cord-263157-8jin6oru	322	60	and	and	CC
cord-263157-8jin6oru	322	61	cellular	cellular	JJ
cord-263157-8jin6oru	322	62	targets	target	NNS
cord-263157-8jin6oru	322	63	inhibits	inhibit	VBZ
cord-263157-8jin6oru	322	64	human	human	JJ
cord-263157-8jin6oru	322	65	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	322	66	virus	virus	NN
cord-263157-8jin6oru	322	67	Type	type	NN
cord-263157-8jin6oru	322	68	1	1	CD
cord-263157-8jin6oru	322	69	replication	replication	NN
cord-263157-8jin6oru	322	70	Inhibition	inhibition	NN
cord-263157-8jin6oru	322	71	of	of	IN
cord-263157-8jin6oru	322	72	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	322	73	by	by	IN
cord-263157-8jin6oru	322	74	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	322	75	vector	vector	NN
cord-263157-8jin6oru	322	76	-	-	HYPH
cord-263157-8jin6oru	322	77	transduced	transduce	VBN
cord-263157-8jin6oru	322	78	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	322	79	in	in	IN
cord-263157-8jin6oru	322	80	T	T	NNP
cord-263157-8jin6oru	322	81	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	322	82	differentiated	differentiate	VBN
cord-263157-8jin6oru	322	83	in	in	IN
cord-263157-8jin6oru	322	84	SCID	SCID	NNP
cord-263157-8jin6oru	322	85	-	-	HYPH
cord-263157-8jin6oru	322	86	hu	hu	NNP
cord-263157-8jin6oru	322	87	mice	mouse	NNS
cord-263157-8jin6oru	322	88	and	and	CC
cord-263157-8jin6oru	322	89	CD34	CD34	NNP
cord-263157-8jin6oru	322	90	+	+	CC
cord-263157-8jin6oru	323	1	progenitor	progenitor	JJ
cord-263157-8jin6oru	323	2	cell	cell	NN
cord-263157-8jin6oru	323	3	-	-	HYPH
cord-263157-8jin6oru	323	4	derived	derive	VBN
cord-263157-8jin6oru	323	5	macrophages	macrophage	NNS
cord-263157-8jin6oru	323	6	Sustained	sustain	VBD
cord-263157-8jin6oru	323	7	small	small	JJ
cord-263157-8jin6oru	323	8	interfering	interfere	VBG
cord-263157-8jin6oru	323	9	RNA	RNA	NNP
cord-263157-8jin6oru	323	10	-	-	HYPH
cord-263157-8jin6oru	323	11	mediated	mediate	VBN
cord-263157-8jin6oru	323	12	human	human	JJ
cord-263157-8jin6oru	323	13	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	323	14	virus	virus	NN
cord-263157-8jin6oru	323	15	type	type	NN
cord-263157-8jin6oru	323	16	1	1	CD
cord-263157-8jin6oru	323	17	inhibition	inhibition	NN
cord-263157-8jin6oru	323	18	in	in	IN
cord-263157-8jin6oru	323	19	primary	primary	JJ
cord-263157-8jin6oru	323	20	macrophages	macrophage	NNS
cord-263157-8jin6oru	323	21	Inhibition	inhibition	NN
cord-263157-8jin6oru	323	22	of	of	IN
cord-263157-8jin6oru	323	23	human	human	JJ
cord-263157-8jin6oru	323	24	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	323	25	virus	virus	NN
cord-263157-8jin6oru	323	26	type	type	NN
cord-263157-8jin6oru	323	27	1	1	CD
cord-263157-8jin6oru	323	28	replication	replication	NN
cord-263157-8jin6oru	323	29	in	in	IN
cord-263157-8jin6oru	323	30	primary	primary	JJ
cord-263157-8jin6oru	323	31	macrophages	macrophage	NNS
cord-263157-8jin6oru	323	32	by	by	IN
cord-263157-8jin6oru	323	33	using	use	VBG
cord-263157-8jin6oru	323	34	Tat	tat	NN
cord-263157-8jin6oru	323	35	-	-	HYPH
cord-263157-8jin6oru	323	36	or	or	CC
cord-263157-8jin6oru	323	37	CCR5-specific	CCR5-specific	NNP
cord-263157-8jin6oru	323	38	small	small	JJ
cord-263157-8jin6oru	323	39	interfering	interfere	VBG
cord-263157-8jin6oru	323	40	RNAs	rna	NNS
cord-263157-8jin6oru	323	41	expressed	express	VBD
cord-263157-8jin6oru	323	42	from	from	IN
cord-263157-8jin6oru	323	43	a	a	DT
cord-263157-8jin6oru	323	44	lentivirus	lentivirus	NN
cord-263157-8jin6oru	323	45	vector	vector	NN
cord-263157-8jin6oru	323	46	Dissecting	dissect	VBG
cord-263157-8jin6oru	323	47	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	323	48	through	through	IN
cord-263157-8jin6oru	323	49	RNA	RNA	NNP
cord-263157-8jin6oru	323	50	interference	interference	NN
cord-263157-8jin6oru	323	51	Aptamers	Aptamers	NNPS
cord-263157-8jin6oru	323	52	directed	direct	VBD
cord-263157-8jin6oru	323	53	to	to	IN
cord-263157-8jin6oru	323	54	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	323	55	reverse	reverse	VB
cord-263157-8jin6oru	323	56	transcriptase	transcriptase	NN
cord-263157-8jin6oru	323	57	display	display	NN
cord-263157-8jin6oru	323	58	greater	great	JJR
cord-263157-8jin6oru	323	59	efficacy	efficacy	NN
cord-263157-8jin6oru	323	60	over	over	IN
cord-263157-8jin6oru	323	61	small	small	JJ
cord-263157-8jin6oru	323	62	hairpin	hairpin	NN
cord-263157-8jin6oru	323	63	RNAs	rna	NNS
cord-263157-8jin6oru	323	64	targeted	target	VBN
cord-263157-8jin6oru	323	65	to	to	IN
cord-263157-8jin6oru	323	66	viral	viral	JJ
cord-263157-8jin6oru	323	67	RNA	RNA	NNP
cord-263157-8jin6oru	323	68	in	in	IN
cord-263157-8jin6oru	323	69	blocking	block	VBG
cord-263157-8jin6oru	323	70	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	323	71	replication	replication	NN
cord-263157-8jin6oru	323	72	Inhibition	inhibition	NN
cord-263157-8jin6oru	323	73	of	of	IN
cord-263157-8jin6oru	323	74	retroviral	retroviral	JJ
cord-263157-8jin6oru	323	75	pathogenesis	pathogenesis	NN
cord-263157-8jin6oru	323	76	by	by	IN
cord-263157-8jin6oru	323	77	RNA	RNA	NNP
cord-263157-8jin6oru	323	78	interference	interference	NN
cord-263157-8jin6oru	323	79	Expression	expression	NN
cord-263157-8jin6oru	323	80	of	of	IN
cord-263157-8jin6oru	323	81	small	small	JJ
cord-263157-8jin6oru	323	82	hairpin	hairpin	NN
cord-263157-8jin6oru	323	83	RNA	RNA	NNP
cord-263157-8jin6oru	323	84	by	by	IN
cord-263157-8jin6oru	323	85	lentivirus	lentivirus	NN
cord-263157-8jin6oru	323	86	-	-	HYPH
cord-263157-8jin6oru	323	87	based	base	VBN
cord-263157-8jin6oru	323	88	vector	vector	NN
cord-263157-8jin6oru	323	89	confers	confer	VBZ
cord-263157-8jin6oru	323	90	efficient	efficient	JJ
cord-263157-8jin6oru	323	91	and	and	CC
cord-263157-8jin6oru	323	92	stable	stable	JJ
cord-263157-8jin6oru	323	93	gene	gene	NN
cord-263157-8jin6oru	323	94	-	-	HYPH
cord-263157-8jin6oru	323	95	suppression	suppression	NN
cord-263157-8jin6oru	323	96	of	of	IN
cord-263157-8jin6oru	323	97	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	323	98	on	on	IN
cord-263157-8jin6oru	323	99	human	human	JJ
cord-263157-8jin6oru	323	100	cells	cell	NNS
cord-263157-8jin6oru	323	101	including	include	VBG
cord-263157-8jin6oru	323	102	primary	primary	JJ
cord-263157-8jin6oru	323	103	non	non	JJ
cord-263157-8jin6oru	323	104	-	-	JJ
cord-263157-8jin6oru	323	105	dividing	dividing	JJ
cord-263157-8jin6oru	323	106	cells	cell	NNS
cord-263157-8jin6oru	323	107	Phenotypic	phenotypic	JJ
cord-263157-8jin6oru	323	108	silencing	silence	VBG
cord-263157-8jin6oru	323	109	of	of	IN
cord-263157-8jin6oru	323	110	cytoplasmic	cytoplasmic	JJ
cord-263157-8jin6oru	323	111	genes	gene	NNS
cord-263157-8jin6oru	323	112	using	use	VBG
cord-263157-8jin6oru	323	113	sequence	sequence	NN
cord-263157-8jin6oru	323	114	-	-	HYPH
cord-263157-8jin6oru	323	115	specific	specific	JJ
cord-263157-8jin6oru	323	116	double	double	RB
cord-263157-8jin6oru	323	117	-	-	HYPH
cord-263157-8jin6oru	323	118	stranded	stranded	JJ
cord-263157-8jin6oru	323	119	short	short	JJ
cord-263157-8jin6oru	323	120	interfering	interfere	VBG
cord-263157-8jin6oru	323	121	RNA	RNA	NNP
cord-263157-8jin6oru	323	122	and	and	CC
cord-263157-8jin6oru	323	123	its	-PRON-	PRP$
cord-263157-8jin6oru	323	124	application	application	NN
cord-263157-8jin6oru	323	125	in	in	IN
cord-263157-8jin6oru	323	126	the	the	DT
cord-263157-8jin6oru	323	127	reverse	reverse	JJ
cord-263157-8jin6oru	323	128	genetics	genetic	NNS
cord-263157-8jin6oru	323	129	of	of	IN
cord-263157-8jin6oru	323	130	wild	wild	JJ
cord-263157-8jin6oru	323	131	type	type	NN
cord-263157-8jin6oru	323	132	negative	negative	JJ
cord-263157-8jin6oru	323	133	-	-	HYPH
cord-263157-8jin6oru	323	134	strand	strand	NN
cord-263157-8jin6oru	323	135	RNA	RNA	NNP
cord-263157-8jin6oru	323	136	viruses	virus	NNS
cord-263157-8jin6oru	324	1	A	a	DT
cord-263157-8jin6oru	324	2	systematic	systematic	JJ
cord-263157-8jin6oru	324	3	analysis	analysis	NN
cord-263157-8jin6oru	324	4	of	of	IN
cord-263157-8jin6oru	324	5	the	the	DT
cord-263157-8jin6oru	324	6	effect	effect	NN
cord-263157-8jin6oru	324	7	of	of	IN
cord-263157-8jin6oru	324	8	target	target	NN
cord-263157-8jin6oru	324	9	RNA	RNA	NNP
cord-263157-8jin6oru	324	10	structure	structure	NN
cord-263157-8jin6oru	324	11	on	on	IN
cord-263157-8jin6oru	324	12	RNA	RNA	NNP
cord-263157-8jin6oru	324	13	interference	interference	NN
cord-263157-8jin6oru	324	14	Positional	positional	JJ
cord-263157-8jin6oru	324	15	effects	effect	NNS
cord-263157-8jin6oru	324	16	of	of	IN
cord-263157-8jin6oru	324	17	short	short	JJ
cord-263157-8jin6oru	324	18	interfering	interfere	VBG
cord-263157-8jin6oru	324	19	RNAs	rna	NNS
cord-263157-8jin6oru	324	20	targeting	target	VBG
cord-263157-8jin6oru	324	21	the	the	DT
cord-263157-8jin6oru	324	22	human	human	JJ
cord-263157-8jin6oru	324	23	coagulation	coagulation	NN
cord-263157-8jin6oru	324	24	trigger	trigger	NN
cord-263157-8jin6oru	324	25	Tissue	tissue	NN
cord-263157-8jin6oru	324	26	Factor	factor	NN
cord-263157-8jin6oru	325	1	The	the	DT
cord-263157-8jin6oru	325	2	virion	virion	NN
cord-263157-8jin6oru	325	3	-	-	:
cord-263157-8jin6oru	325	4	associated	associate	VBN
cord-263157-8jin6oru	325	5	incoming	income	VBG
cord-263157-8jin6oru	325	6	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	325	7	RNA	RNA	NNP
cord-263157-8jin6oru	325	8	genome	genome	NN
cord-263157-8jin6oru	325	9	is	be	VBZ
cord-263157-8jin6oru	325	10	not	not	RB
cord-263157-8jin6oru	325	11	targeted	target	VBN
cord-263157-8jin6oru	325	12	by	by	IN
cord-263157-8jin6oru	325	13	RNA	RNA	NNP
cord-263157-8jin6oru	325	14	interference	interference	NN
cord-263157-8jin6oru	326	1	A	a	DT
cord-263157-8jin6oru	326	2	system	system	NN
cord-263157-8jin6oru	326	3	for	for	IN
cord-263157-8jin6oru	326	4	stable	stable	JJ
cord-263157-8jin6oru	326	5	expression	expression	NN
cord-263157-8jin6oru	326	6	of	of	IN
cord-263157-8jin6oru	326	7	short	short	JJ
cord-263157-8jin6oru	326	8	interfering	interfere	VBG
cord-263157-8jin6oru	326	9	RNAs	rna	NNS
cord-263157-8jin6oru	326	10	in	in	IN
cord-263157-8jin6oru	326	11	mammalian	mammalian	JJ
cord-263157-8jin6oru	326	12	cells	cell	NNS
cord-263157-8jin6oru	326	13	Efficient	efficient	JJ
cord-263157-8jin6oru	326	14	gene	gene	NN
cord-263157-8jin6oru	326	15	transfer	transfer	NN
cord-263157-8jin6oru	326	16	of	of	IN
cord-263157-8jin6oru	326	17	HIV-1-specific	HIV-1-specific	NNP
cord-263157-8jin6oru	326	18	short	short	JJ
cord-263157-8jin6oru	326	19	hairpin	hairpin	NNP
cord-263157-8jin6oru	326	20	RNA	RNA	NNP
cord-263157-8jin6oru	326	21	into	into	IN
cord-263157-8jin6oru	326	22	human	human	JJ
cord-263157-8jin6oru	326	23	lymphocytic	lymphocytic	JJ
cord-263157-8jin6oru	326	24	cells	cell	NNS
cord-263157-8jin6oru	326	25	using	use	VBG
cord-263157-8jin6oru	326	26	recombinant	recombinant	JJ
cord-263157-8jin6oru	326	27	adeno	adeno	NN
cord-263157-8jin6oru	326	28	-	-	HYPH
cord-263157-8jin6oru	326	29	associated	associate	VBN
cord-263157-8jin6oru	326	30	virus	virus	NN
cord-263157-8jin6oru	326	31	vectors	vector	VBZ
cord-263157-8jin6oru	326	32	Human	human	JJ
cord-263157-8jin6oru	326	33	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	326	34	virus	virus	NN
cord-263157-8jin6oru	326	35	type	type	NN
cord-263157-8jin6oru	326	36	1	1	CD
cord-263157-8jin6oru	326	37	escapes	escape	VBZ
cord-263157-8jin6oru	326	38	from	from	IN
cord-263157-8jin6oru	326	39	RNA	RNA	NNP
cord-263157-8jin6oru	327	1	interference	interference	NN
cord-263157-8jin6oru	327	2	-	-	HYPH
cord-263157-8jin6oru	327	3	mediated	mediate	VBN
cord-263157-8jin6oru	327	4	inhibition	inhibition	NN
cord-263157-8jin6oru	327	5	Lentiviral	Lentiviral	NNP
cord-263157-8jin6oru	327	6	delivery	delivery	NN
cord-263157-8jin6oru	327	7	of	of	IN
cord-263157-8jin6oru	327	8	short	short	JJ
cord-263157-8jin6oru	327	9	hairpin	hairpin	NN
cord-263157-8jin6oru	327	10	RNAs	rna	NNS
cord-263157-8jin6oru	327	11	protects	protect	VBZ
cord-263157-8jin6oru	327	12	CD4	CD4	NNP
cord-263157-8jin6oru	327	13	T	T	NNP
cord-263157-8jin6oru	327	14	cells	cell	NNS
cord-263157-8jin6oru	327	15	from	from	IN
cord-263157-8jin6oru	327	16	multiple	multiple	JJ
cord-263157-8jin6oru	327	17	clades	clade	NNS
cord-263157-8jin6oru	327	18	and	and	CC
cord-263157-8jin6oru	327	19	primary	primary	JJ
cord-263157-8jin6oru	327	20	isolates	isolate	NNS
cord-263157-8jin6oru	327	21	of	of	IN
cord-263157-8jin6oru	327	22	HIV	HIV	NNP
cord-263157-8jin6oru	327	23	Second	Second	NNP
cord-263157-8jin6oru	327	24	-	-	HYPH
cord-263157-8jin6oru	327	25	generation	generation	NN
cord-263157-8jin6oru	327	26	shRNA	shRNA	NNP
cord-263157-8jin6oru	327	27	libraries	library	NNS
cord-263157-8jin6oru	327	28	covering	cover	VBG
cord-263157-8jin6oru	327	29	the	the	DT
cord-263157-8jin6oru	327	30	mouse	mouse	NN
cord-263157-8jin6oru	327	31	and	and	CC
cord-263157-8jin6oru	327	32	human	human	NN
cord-263157-8jin6oru	327	33	genomes	genome	NNS
cord-263157-8jin6oru	327	34	Is	be	VBZ
cord-263157-8jin6oru	327	35	RNA	RNA	NNP
cord-263157-8jin6oru	327	36	interference	interference	NN
cord-263157-8jin6oru	327	37	involved	involve	VBN
cord-263157-8jin6oru	327	38	in	in	IN
cord-263157-8jin6oru	327	39	intrinsic	intrinsic	JJ
cord-263157-8jin6oru	327	40	antiviral	antiviral	JJ
cord-263157-8jin6oru	327	41	immunity	immunity	NN
cord-263157-8jin6oru	327	42	in	in	IN
cord-263157-8jin6oru	327	43	mammals	mammal	NNS
cord-263157-8jin6oru	327	44	Induction	Induction	NNP
cord-263157-8jin6oru	327	45	and	and	CC
cord-263157-8jin6oru	327	46	suppression	suppression	NN
cord-263157-8jin6oru	327	47	of	of	IN
cord-263157-8jin6oru	327	48	RNA	RNA	NNP
cord-263157-8jin6oru	327	49	silencing	silencing	NN
cord-263157-8jin6oru	327	50	:	:	:
cord-263157-8jin6oru	327	51	insights	insight	NNS
cord-263157-8jin6oru	327	52	from	from	IN
cord-263157-8jin6oru	327	53	viral	viral	JJ
cord-263157-8jin6oru	327	54	infections	infection	NNS
cord-263157-8jin6oru	327	55	Type	type	NN
cord-263157-8jin6oru	327	56	1	1	CD
cord-263157-8jin6oru	327	57	interferons	interferon	NNS
cord-263157-8jin6oru	327	58	and	and	CC
cord-263157-8jin6oru	327	59	the	the	DT
cord-263157-8jin6oru	327	60	virus	virus	NN
cord-263157-8jin6oru	327	61	-	-	HYPH
cord-263157-8jin6oru	327	62	host	host	NN
cord-263157-8jin6oru	327	63	relationship	relationship	NN
cord-263157-8jin6oru	327	64	:	:	:
cord-263157-8jin6oru	327	65	a	a	DT
cord-263157-8jin6oru	327	66	lesson	lesson	NN
cord-263157-8jin6oru	327	67	in	in	IN
cord-263157-8jin6oru	327	68	detente	detente	NN
cord-263157-8jin6oru	327	69	Identification	identification	NN
cord-263157-8jin6oru	327	70	of	of	IN
cord-263157-8jin6oru	327	71	microRNAs	microRNAs	NNPS
cord-263157-8jin6oru	327	72	of	of	IN
cord-263157-8jin6oru	327	73	the	the	DT
cord-263157-8jin6oru	327	74	herpesvirus	herpesvirus	NN
cord-263157-8jin6oru	327	75	family	family	NN
cord-263157-8jin6oru	327	76	Evidence	evidence	NN
cord-263157-8jin6oru	327	77	that	that	IN
cord-263157-8jin6oru	327	78	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	327	79	encodes	encode	VBZ
cord-263157-8jin6oru	327	80	an	an	DT
cord-263157-8jin6oru	327	81	siRNA	sirna	NN
cord-263157-8jin6oru	327	82	and	and	CC
cord-263157-8jin6oru	327	83	a	a	DT
cord-263157-8jin6oru	327	84	suppressor	suppressor	NN
cord-263157-8jin6oru	327	85	of	of	IN
cord-263157-8jin6oru	327	86	RNA	RNA	NNP
cord-263157-8jin6oru	327	87	silencing	silence	VBG
cord-263157-8jin6oru	327	88	The	the	DT
cord-263157-8jin6oru	327	89	Ebola	Ebola	NNP
cord-263157-8jin6oru	327	90	virus	virus	NN
cord-263157-8jin6oru	327	91	VP35	VP35	NNP
cord-263157-8jin6oru	327	92	protein	protein	NN
cord-263157-8jin6oru	327	93	is	be	VBZ
cord-263157-8jin6oru	327	94	a	a	DT
cord-263157-8jin6oru	327	95	suppressor	suppressor	NN
cord-263157-8jin6oru	327	96	of	of	IN
cord-263157-8jin6oru	327	97	RNA	RNA	NNP
cord-263157-8jin6oru	327	98	silencing	silence	VBG
cord-263157-8jin6oru	327	99	Analysis	Analysis	NNP
cord-263157-8jin6oru	327	100	of	of	IN
cord-263157-8jin6oru	327	101	the	the	DT
cord-263157-8jin6oru	327	102	Interaction	Interaction	NNP
cord-263157-8jin6oru	327	103	of	of	IN
cord-263157-8jin6oru	327	104	Primate	Primate	NNP
cord-263157-8jin6oru	327	105	Retroviruses	Retroviruses	NNPS
cord-263157-8jin6oru	327	106	with	with	IN
cord-263157-8jin6oru	327	107	the	the	DT
cord-263157-8jin6oru	327	108	Human	Human	NNP
cord-263157-8jin6oru	327	109	RNA	RNA	NNP
cord-263157-8jin6oru	327	110	Interference	Interference	NNP
cord-263157-8jin6oru	327	111	Machinery	Machinery	NNP
cord-263157-8jin6oru	327	112	Induction	Induction	NNP
cord-263157-8jin6oru	327	113	and	and	CC
cord-263157-8jin6oru	327	114	suppression	suppression	NN
cord-263157-8jin6oru	327	115	of	of	IN
cord-263157-8jin6oru	327	116	RNA	RNA	NNP
cord-263157-8jin6oru	327	117	silencing	silencing	NN
cord-263157-8jin6oru	327	118	by	by	IN
cord-263157-8jin6oru	327	119	an	an	DT
cord-263157-8jin6oru	327	120	animal	animal	NN
cord-263157-8jin6oru	327	121	virus	virus	NN
cord-263157-8jin6oru	327	122	Suppression	Suppression	NNP
cord-263157-8jin6oru	327	123	of	of	IN
cord-263157-8jin6oru	327	124	microRNA	microRNA	NNP
cord-263157-8jin6oru	327	125	-	-	HYPH
cord-263157-8jin6oru	327	126	silencing	silence	VBG
cord-263157-8jin6oru	327	127	pathway	pathway	NN
cord-263157-8jin6oru	327	128	by	by	IN
cord-263157-8jin6oru	327	129	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	327	130	during	during	IN
cord-263157-8jin6oru	327	131	virus	virus	NN
cord-263157-8jin6oru	327	132	replication	replication	NN
cord-263157-8jin6oru	327	133	Host	Host	NNP
cord-263157-8jin6oru	327	134	immune	immune	JJ
cord-263157-8jin6oru	327	135	system	system	NN
cord-263157-8jin6oru	327	136	gene	gene	NN
cord-263157-8jin6oru	327	137	targeting	target	VBG
cord-263157-8jin6oru	327	138	by	by	IN
cord-263157-8jin6oru	327	139	a	a	DT
cord-263157-8jin6oru	327	140	viral	viral	JJ
cord-263157-8jin6oru	327	141	miRNA	miRNA	NNP
cord-263157-8jin6oru	327	142	Cellular	Cellular	NNP
cord-263157-8jin6oru	327	143	microRNAs	microRNAs	NNPS
cord-263157-8jin6oru	327	144	contribute	contribute	VBP
cord-263157-8jin6oru	327	145	to	to	IN
cord-263157-8jin6oru	327	146	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	327	147	latency	latency	NN
cord-263157-8jin6oru	327	148	in	in	IN
cord-263157-8jin6oru	327	149	resting	rest	VBG
cord-263157-8jin6oru	327	150	primary	primary	JJ
cord-263157-8jin6oru	327	151	CD4(+	CD4(+	NNP
cord-263157-8jin6oru	327	152	)	)	-RRB-
cord-263157-8jin6oru	328	1	T	T	NNP
cord-263157-8jin6oru	328	2	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	328	3	Interferon	Interferon	VBN
cord-263157-8jin6oru	328	4	modulation	modulation	NN
cord-263157-8jin6oru	328	5	of	of	IN
cord-263157-8jin6oru	328	6	cellular	cellular	JJ
cord-263157-8jin6oru	328	7	microRNAs	microrna	NNS
cord-263157-8jin6oru	328	8	as	as	IN
cord-263157-8jin6oru	328	9	an	an	DT
cord-263157-8jin6oru	328	10	antiviral	antiviral	JJ
cord-263157-8jin6oru	328	11	mechanism	mechanism	NN
cord-263157-8jin6oru	328	12	Human	human	JJ
cord-263157-8jin6oru	328	13	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	328	14	virus	virus	NN
cord-263157-8jin6oru	328	15	type	type	NN
cord-263157-8jin6oru	328	16	1	1	CD
cord-263157-8jin6oru	328	17	escape	escape	NN
cord-263157-8jin6oru	328	18	from	from	IN
cord-263157-8jin6oru	328	19	RNA	RNA	NNP
cord-263157-8jin6oru	328	20	interference	interference	NN
cord-263157-8jin6oru	328	21	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	328	22	can	can	MD
cord-263157-8jin6oru	328	23	escape	escape	VB
cord-263157-8jin6oru	328	24	from	from	IN
cord-263157-8jin6oru	328	25	RNA	RNA	NNP
cord-263157-8jin6oru	328	26	interference	interference	NN
cord-263157-8jin6oru	328	27	by	by	IN
cord-263157-8jin6oru	328	28	evolving	evolve	VBG
cord-263157-8jin6oru	328	29	an	an	DT
cord-263157-8jin6oru	328	30	alternative	alternative	JJ
cord-263157-8jin6oru	328	31	structure	structure	NN
cord-263157-8jin6oru	328	32	in	in	IN
cord-263157-8jin6oru	328	33	its	-PRON-	PRP$
cord-263157-8jin6oru	328	34	RNA	RNA	NNP
cord-263157-8jin6oru	328	35	genome	genome	NN
cord-263157-8jin6oru	328	36	Lower	low	JJR
cord-263157-8jin6oru	328	37	in	in	IN
cord-263157-8jin6oru	328	38	vivo	vivo	NN
cord-263157-8jin6oru	328	39	mutation	mutation	NN
cord-263157-8jin6oru	328	40	rate	rate	NN
cord-263157-8jin6oru	328	41	of	of	IN
cord-263157-8jin6oru	328	42	human	human	JJ
cord-263157-8jin6oru	328	43	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	328	44	virus	virus	NN
cord-263157-8jin6oru	328	45	type	type	NN
cord-263157-8jin6oru	328	46	1	1	CD
cord-263157-8jin6oru	328	47	than	than	IN
cord-263157-8jin6oru	328	48	that	that	DT
cord-263157-8jin6oru	328	49	predicted	predict	VBD
cord-263157-8jin6oru	328	50	from	from	IN
cord-263157-8jin6oru	328	51	the	the	DT
cord-263157-8jin6oru	328	52	fidelity	fidelity	NN
cord-263157-8jin6oru	328	53	of	of	IN
cord-263157-8jin6oru	328	54	purified	purify	VBN
cord-263157-8jin6oru	328	55	reverse	reverse	NN
cord-263157-8jin6oru	328	56	transcriptase	transcriptase	NN
cord-263157-8jin6oru	328	57	Rapid	rapid	JJ
cord-263157-8jin6oru	328	58	turnover	turnover	NN
cord-263157-8jin6oru	328	59	of	of	IN
cord-263157-8jin6oru	328	60	plasma	plasma	NN
cord-263157-8jin6oru	328	61	virions	virion	NNS
cord-263157-8jin6oru	328	62	and	and	CC
cord-263157-8jin6oru	328	63	CD4	CD4	NNP
cord-263157-8jin6oru	328	64	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	328	65	in	in	IN
cord-263157-8jin6oru	328	66	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	328	67	infection	infection	NN
cord-263157-8jin6oru	328	68	Multiply	multiply	VB
cord-263157-8jin6oru	328	69	infected	infected	JJ
cord-263157-8jin6oru	328	70	spleen	spleen	NN
cord-263157-8jin6oru	328	71	cells	cell	NNS
cord-263157-8jin6oru	328	72	in	in	IN
cord-263157-8jin6oru	328	73	HIV	HIV	NNP
cord-263157-8jin6oru	328	74	patients	patient	NNS
cord-263157-8jin6oru	328	75	HIV	HIV	NNP
cord-263157-8jin6oru	328	76	population	population	NN
cord-263157-8jin6oru	328	77	dynamics	dynamic	NNS
cord-263157-8jin6oru	328	78	in	in	IN
cord-263157-8jin6oru	328	79	vivo	vivo	NN
cord-263157-8jin6oru	328	80	:	:	:
cord-263157-8jin6oru	328	81	implications	implication	NNS
cord-263157-8jin6oru	328	82	for	for	IN
cord-263157-8jin6oru	328	83	genetic	genetic	JJ
cord-263157-8jin6oru	328	84	variation	variation	NN
cord-263157-8jin6oru	328	85	,	,	,
cord-263157-8jin6oru	328	86	pathogenesis	pathogenesis	NN
cord-263157-8jin6oru	328	87	,	,	,
cord-263157-8jin6oru	328	88	and	and	CC
cord-263157-8jin6oru	328	89	therapy	therapy	NN
cord-263157-8jin6oru	328	90	Viruses	virus	NNS
cord-263157-8jin6oru	328	91	as	as	IN
cord-263157-8jin6oru	328	92	quasispecies	quasispecie	NNS
cord-263157-8jin6oru	328	93	:	:	:
cord-263157-8jin6oru	328	94	biological	biological	JJ
cord-263157-8jin6oru	328	95	implications	implication	NNS
cord-263157-8jin6oru	329	1	HIV	HIV	NNP
cord-263157-8jin6oru	329	2	Sequence	Sequence	NNP
cord-263157-8jin6oru	329	3	Compendium	Compendium	NNP
cord-263157-8jin6oru	329	4	Sequence	sequence	NN
cord-263157-8jin6oru	329	5	homology	homology	NN
cord-263157-8jin6oru	329	6	required	require	VBN
cord-263157-8jin6oru	329	7	by	by	IN
cord-263157-8jin6oru	329	8	human	human	JJ
cord-263157-8jin6oru	329	9	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	329	10	virus	virus	NN
cord-263157-8jin6oru	329	11	type	type	NN
cord-263157-8jin6oru	329	12	1	1	CD
cord-263157-8jin6oru	329	13	to	to	TO
cord-263157-8jin6oru	329	14	escape	escape	VB
cord-263157-8jin6oru	329	15	from	from	IN
cord-263157-8jin6oru	329	16	short	short	JJ
cord-263157-8jin6oru	329	17	interfering	interfere	VBG
cord-263157-8jin6oru	329	18	RNAs	rna	NNS
cord-263157-8jin6oru	329	19	RNA	RNA	NNP
cord-263157-8jin6oru	329	20	interference	interference	NN
cord-263157-8jin6oru	329	21	of	of	IN
cord-263157-8jin6oru	329	22	HIV	HIV	NNP
cord-263157-8jin6oru	329	23	replication	replication	NN
cord-263157-8jin6oru	329	24	Silencing	silencing	NN
cord-263157-8jin6oru	329	25	of	of	IN
cord-263157-8jin6oru	329	26	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	329	27	with	with	IN
cord-263157-8jin6oru	329	28	RNA	RNA	NNP
cord-263157-8jin6oru	329	29	interference	interference	NN
cord-263157-8jin6oru	329	30	:	:	:
cord-263157-8jin6oru	329	31	a	a	DT
cord-263157-8jin6oru	329	32	multiple	multiple	JJ
cord-263157-8jin6oru	329	33	shRNA	shrna	NN
cord-263157-8jin6oru	329	34	approach	approach	NN
cord-263157-8jin6oru	329	35	Design	Design	NNP
cord-263157-8jin6oru	329	36	of	of	IN
cord-263157-8jin6oru	329	37	extended	extended	JJ
cord-263157-8jin6oru	329	38	short	short	JJ
cord-263157-8jin6oru	329	39	hairpin	hairpin	NN
cord-263157-8jin6oru	329	40	RNAs	rna	NNS
cord-263157-8jin6oru	329	41	for	for	IN
cord-263157-8jin6oru	329	42	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	329	43	inhibition	inhibition	NN
cord-263157-8jin6oru	329	44	Optimization	optimization	NN
cord-263157-8jin6oru	329	45	and	and	CC
cord-263157-8jin6oru	329	46	functional	functional	JJ
cord-263157-8jin6oru	329	47	effects	effect	NNS
cord-263157-8jin6oru	329	48	of	of	IN
cord-263157-8jin6oru	329	49	stable	stable	JJ
cord-263157-8jin6oru	329	50	short	short	JJ
cord-263157-8jin6oru	329	51	hairpin	hairpin	NN
cord-263157-8jin6oru	329	52	RNA	RNA	NNP
cord-263157-8jin6oru	329	53	expression	expression	NN
cord-263157-8jin6oru	329	54	in	in	IN
cord-263157-8jin6oru	329	55	primary	primary	JJ
cord-263157-8jin6oru	329	56	human	human	JJ
cord-263157-8jin6oru	329	57	lymphocytes	lymphocyte	NNS
cord-263157-8jin6oru	329	58	via	via	IN
cord-263157-8jin6oru	329	59	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	329	60	vectors	vector	NNS
cord-263157-8jin6oru	329	61	Fatality	Fatality	NNP
cord-263157-8jin6oru	329	62	in	in	IN
cord-263157-8jin6oru	329	63	mice	mouse	NNS
cord-263157-8jin6oru	329	64	due	due	JJ
cord-263157-8jin6oru	329	65	to	to	IN
cord-263157-8jin6oru	329	66	oversaturation	oversaturation	NN
cord-263157-8jin6oru	329	67	of	of	IN
cord-263157-8jin6oru	329	68	cellular	cellular	JJ
cord-263157-8jin6oru	329	69	microRNA	microRNA	NNP
cord-263157-8jin6oru	329	70	/	/	SYM
cord-263157-8jin6oru	329	71	short	short	JJ
cord-263157-8jin6oru	329	72	hairpin	hairpin	NNP
cord-263157-8jin6oru	329	73	RNA	RNA	NNP
cord-263157-8jin6oru	329	74	pathways	pathway	NNS
cord-263157-8jin6oru	329	75	Optimization	optimization	NN
cord-263157-8jin6oru	329	76	and	and	CC
cord-263157-8jin6oru	329	77	characterization	characterization	NN
cord-263157-8jin6oru	329	78	of	of	IN
cord-263157-8jin6oru	329	79	tRNA	trna	NN
cord-263157-8jin6oru	329	80	-	-	HYPH
cord-263157-8jin6oru	329	81	shRNA	shrna	NN
cord-263157-8jin6oru	329	82	expression	expression	NN
cord-263157-8jin6oru	329	83	constructs	construct	VBZ
cord-263157-8jin6oru	329	84	Escape	Escape	NNP
cord-263157-8jin6oru	329	85	from	from	IN
cord-263157-8jin6oru	329	86	the	the	DT
cord-263157-8jin6oru	329	87	interferon	interferon	NN
cord-263157-8jin6oru	329	88	response	response	NN
cord-263157-8jin6oru	329	89	associated	associate	VBN
cord-263157-8jin6oru	329	90	with	with	IN
cord-263157-8jin6oru	329	91	RNA	RNA	NNP
cord-263157-8jin6oru	329	92	interference	interference	NN
cord-263157-8jin6oru	329	93	using	use	VBG
cord-263157-8jin6oru	329	94	vectors	vector	NNS
cord-263157-8jin6oru	329	95	that	that	WDT
cord-263157-8jin6oru	329	96	encode	encode	VBP
cord-263157-8jin6oru	329	97	long	long	RB
cord-263157-8jin6oru	329	98	modified	modify	VBN
cord-263157-8jin6oru	329	99	hairpin	hairpin	NN
cord-263157-8jin6oru	329	100	-	-	HYPH
cord-263157-8jin6oru	329	101	RNA	RNA	NNP
cord-263157-8jin6oru	329	102	Inhibition	Inhibition	NNP
cord-263157-8jin6oru	329	103	of	of	IN
cord-263157-8jin6oru	329	104	human	human	JJ
cord-263157-8jin6oru	329	105	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	329	106	virus	virus	NN
cord-263157-8jin6oru	329	107	type	type	NN
cord-263157-8jin6oru	329	108	1	1	CD
cord-263157-8jin6oru	329	109	by	by	IN
cord-263157-8jin6oru	329	110	RNA	RNA	NNP
cord-263157-8jin6oru	329	111	interference	interference	NN
cord-263157-8jin6oru	329	112	using	use	VBG
cord-263157-8jin6oru	329	113	long	long	JJ
cord-263157-8jin6oru	329	114	-	-	HYPH
cord-263157-8jin6oru	329	115	hairpin	hairpin	NN
cord-263157-8jin6oru	329	116	RNA	RNA	NNP
cord-263157-8jin6oru	329	117	Effective	effective	JJ
cord-263157-8jin6oru	329	118	suppression	suppression	NN
cord-263157-8jin6oru	329	119	of	of	IN
cord-263157-8jin6oru	329	120	human	human	JJ
cord-263157-8jin6oru	329	121	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	329	122	virus	virus	NN
cord-263157-8jin6oru	329	123	type	type	NN
cord-263157-8jin6oru	329	124	1	1	CD
cord-263157-8jin6oru	329	125	through	through	IN
cord-263157-8jin6oru	329	126	a	a	DT
cord-263157-8jin6oru	329	127	combination	combination	NN
cord-263157-8jin6oru	329	128	of	of	IN
cord-263157-8jin6oru	329	129	short	short	JJ
cord-263157-8jin6oru	329	130	-	-	HYPH
cord-263157-8jin6oru	329	131	or	or	CC
cord-263157-8jin6oru	329	132	longhairpin	longhairpin	JJ
cord-263157-8jin6oru	329	133	RNAs	rna	NNS
cord-263157-8jin6oru	329	134	targeting	target	VBG
cord-263157-8jin6oru	329	135	essential	essential	JJ
cord-263157-8jin6oru	329	136	sequences	sequence	NNS
cord-263157-8jin6oru	329	137	for	for	IN
cord-263157-8jin6oru	329	138	retroviral	retroviral	JJ
cord-263157-8jin6oru	329	139	integration	integration	NN
cord-263157-8jin6oru	329	140	Expression	expression	NN
cord-263157-8jin6oru	329	141	of	of	IN
cord-263157-8jin6oru	329	142	long	long	JJ
cord-263157-8jin6oru	329	143	anti	anti	JJ
cord-263157-8jin6oru	329	144	-	-	JJ
cord-263157-8jin6oru	329	145	HIV-1	hiv-1	JJ
cord-263157-8jin6oru	329	146	hairpin	hairpin	NN
cord-263157-8jin6oru	329	147	RNAs	rna	NNS
cord-263157-8jin6oru	329	148	for	for	IN
cord-263157-8jin6oru	329	149	the	the	DT
cord-263157-8jin6oru	329	150	generation	generation	NN
cord-263157-8jin6oru	329	151	of	of	IN
cord-263157-8jin6oru	329	152	multiple	multiple	JJ
cord-263157-8jin6oru	329	153	siRNAs	sirna	NNS
cord-263157-8jin6oru	329	154	:	:	:
cord-263157-8jin6oru	329	155	Advantages	advantage	NNS
cord-263157-8jin6oru	329	156	and	and	CC
cord-263157-8jin6oru	329	157	limitations	limitation	NNS
cord-263157-8jin6oru	329	158	A	a	DT
cord-263157-8jin6oru	329	159	novel	novel	JJ
cord-263157-8jin6oru	329	160	approach	approach	NN
cord-263157-8jin6oru	329	161	for	for	IN
cord-263157-8jin6oru	329	162	inhibition	inhibition	NN
cord-263157-8jin6oru	329	163	of	of	IN
cord-263157-8jin6oru	329	164	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	329	165	by	by	IN
cord-263157-8jin6oru	329	166	RNA	RNA	NNP
cord-263157-8jin6oru	329	167	interference	interference	NN
cord-263157-8jin6oru	329	168	:	:	:
cord-263157-8jin6oru	329	169	counteracting	counteract	VBG
cord-263157-8jin6oru	329	170	viral	viral	JJ
cord-263157-8jin6oru	329	171	escape	escape	NN
cord-263157-8jin6oru	329	172	with	with	IN
cord-263157-8jin6oru	329	173	a	a	DT
cord-263157-8jin6oru	329	174	second	second	JJ
cord-263157-8jin6oru	329	175	generation	generation	NN
cord-263157-8jin6oru	329	176	of	of	IN
cord-263157-8jin6oru	329	177	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	329	178	Endoribonuclease	Endoribonuclease	NNP
cord-263157-8jin6oru	329	179	-	-	HYPH
cord-263157-8jin6oru	329	180	Prepared	Prepared	NNP
cord-263157-8jin6oru	329	181	Short	Short	NNP
cord-263157-8jin6oru	329	182	Interfering	Interfering	NNP
cord-263157-8jin6oru	329	183	RNAs	rna	NNS
cord-263157-8jin6oru	330	1	Induce	induce	VB
cord-263157-8jin6oru	330	2	Effective	effective	JJ
cord-263157-8jin6oru	330	3	and	and	CC
cord-263157-8jin6oru	330	4	Specific	specific	JJ
cord-263157-8jin6oru	330	5	Inhibition	inhibition	NN
cord-263157-8jin6oru	330	6	of	of	IN
cord-263157-8jin6oru	330	7	Human	Human	NNP
cord-263157-8jin6oru	330	8	Immunodeficiency	Immunodeficiency	NNP
cord-263157-8jin6oru	330	9	Virus	Virus	NNP
cord-263157-8jin6oru	330	10	Type	Type	NNP
cord-263157-8jin6oru	330	11	1	1	CD
cord-263157-8jin6oru	330	12	Replication	Replication	NNP
cord-263157-8jin6oru	330	13	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	330	14	generated	generate	VBN
cord-263157-8jin6oru	330	15	by	by	IN
cord-263157-8jin6oru	330	16	recombinant	recombinant	JJ
cord-263157-8jin6oru	330	17	human	human	NN
cord-263157-8jin6oru	330	18	Dicer	Dicer	NNP
cord-263157-8jin6oru	330	19	induce	induce	VB
cord-263157-8jin6oru	330	20	specific	specific	JJ
cord-263157-8jin6oru	330	21	and	and	CC
cord-263157-8jin6oru	330	22	significant	significant	JJ
cord-263157-8jin6oru	330	23	but	but	CC
cord-263157-8jin6oru	330	24	target	target	NN
cord-263157-8jin6oru	330	25	site	site	NN
cord-263157-8jin6oru	330	26	-	-	HYPH
cord-263157-8jin6oru	330	27	independent	independent	JJ
cord-263157-8jin6oru	330	28	gene	gene	NN
cord-263157-8jin6oru	330	29	silencing	silence	VBG
cord-263157-8jin6oru	330	30	in	in	IN
cord-263157-8jin6oru	330	31	human	human	JJ
cord-263157-8jin6oru	330	32	cells	cell	NNS
cord-263157-8jin6oru	330	33	Recombinant	recombinant	JJ
cord-263157-8jin6oru	330	34	Dicer	Dicer	NNP
cord-263157-8jin6oru	330	35	efficiently	efficiently	RB
cord-263157-8jin6oru	330	36	converts	convert	VBZ
cord-263157-8jin6oru	330	37	large	large	JJ
cord-263157-8jin6oru	330	38	dsRNAs	dsRNAs	NNP
cord-263157-8jin6oru	330	39	into	into	IN
cord-263157-8jin6oru	330	40	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	330	41	suitable	suitable	JJ
cord-263157-8jin6oru	330	42	for	for	IN
cord-263157-8jin6oru	330	43	gene	gene	NN
cord-263157-8jin6oru	330	44	silencing	silence	VBG
cord-263157-8jin6oru	330	45	Lentiviral	Lentiviral	NNP
cord-263157-8jin6oru	330	46	vector	vector	NN
cord-263157-8jin6oru	330	47	delivery	delivery	NN
cord-263157-8jin6oru	330	48	of	of	IN
cord-263157-8jin6oru	330	49	siRNA	siRNA	NNP
cord-263157-8jin6oru	330	50	and	and	CC
cord-263157-8jin6oru	330	51	shRNA	shrna	NN
cord-263157-8jin6oru	330	52	encoding	encode	VBG
cord-263157-8jin6oru	330	53	genes	gene	NNS
cord-263157-8jin6oru	330	54	into	into	IN
cord-263157-8jin6oru	330	55	cultured	cultured	JJ
cord-263157-8jin6oru	330	56	and	and	CC
cord-263157-8jin6oru	330	57	primary	primary	JJ
cord-263157-8jin6oru	330	58	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	330	59	cells	cell	NNS
cord-263157-8jin6oru	330	60	Suppression	suppression	NN
cord-263157-8jin6oru	330	61	of	of	IN
cord-263157-8jin6oru	330	62	chemokine	chemokine	JJ
cord-263157-8jin6oru	330	63	receptor	receptor	NN
cord-263157-8jin6oru	330	64	expression	expression	NN
cord-263157-8jin6oru	330	65	by	by	IN
cord-263157-8jin6oru	330	66	RNA	RNA	NNP
cord-263157-8jin6oru	330	67	interference	interference	NN
cord-263157-8jin6oru	330	68	allows	allow	VBZ
cord-263157-8jin6oru	330	69	for	for	IN
cord-263157-8jin6oru	330	70	inhibition	inhibition	NN
cord-263157-8jin6oru	330	71	of	of	IN
cord-263157-8jin6oru	330	72	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	330	73	replication	replication	NN
cord-263157-8jin6oru	330	74	Inhibiting	inhibit	VBG
cord-263157-8jin6oru	330	75	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	330	76	infection	infection	NN
cord-263157-8jin6oru	330	77	in	in	IN
cord-263157-8jin6oru	330	78	human	human	JJ
cord-263157-8jin6oru	330	79	T	t	NN
cord-263157-8jin6oru	330	80	cells	cell	NNS
cord-263157-8jin6oru	330	81	by	by	IN
cord-263157-8jin6oru	330	82	lentiviral	lentiviral	RB
cord-263157-8jin6oru	330	83	-	-	HYPH
cord-263157-8jin6oru	330	84	mediated	mediate	VBN
cord-263157-8jin6oru	330	85	delivery	delivery	NN
cord-263157-8jin6oru	330	86	of	of	IN
cord-263157-8jin6oru	330	87	small	small	JJ
cord-263157-8jin6oru	330	88	interfering	interfere	VBG
cord-263157-8jin6oru	330	89	RNA	RNA	NNP
cord-263157-8jin6oru	330	90	against	against	IN
cord-263157-8jin6oru	330	91	CCR5	CCR5	NNP
cord-263157-8jin6oru	330	92	An	an	DT
cord-263157-8jin6oru	330	93	essential	essential	JJ
cord-263157-8jin6oru	330	94	role	role	NN
cord-263157-8jin6oru	330	95	for	for	IN
cord-263157-8jin6oru	330	96	LEDGF	LEDGF	NNP
cord-263157-8jin6oru	330	97	/	/	SYM
cord-263157-8jin6oru	330	98	p75	p75	NN
cord-263157-8jin6oru	330	99	in	in	IN
cord-263157-8jin6oru	330	100	HIV	HIV	NNP
cord-263157-8jin6oru	330	101	integration	integration	NN
cord-263157-8jin6oru	330	102	LEDGF	LEDGF	NNP
cord-263157-8jin6oru	330	103	/	/	SYM
cord-263157-8jin6oru	330	104	p75	p75	NNP
cord-263157-8jin6oru	330	105	is	be	VBZ
cord-263157-8jin6oru	330	106	essential	essential	JJ
cord-263157-8jin6oru	330	107	for	for	IN
cord-263157-8jin6oru	330	108	nuclear	nuclear	JJ
cord-263157-8jin6oru	330	109	and	and	CC
cord-263157-8jin6oru	330	110	chromosomal	chromosomal	JJ
cord-263157-8jin6oru	330	111	targeting	targeting	NN
cord-263157-8jin6oru	330	112	of	of	IN
cord-263157-8jin6oru	330	113	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	330	114	integrase	integrase	NN
cord-263157-8jin6oru	330	115	in	in	IN
cord-263157-8jin6oru	330	116	human	human	JJ
cord-263157-8jin6oru	330	117	cells	cell	NNS
cord-263157-8jin6oru	331	1	The	the	DT
cord-263157-8jin6oru	331	2	inner	inner	JJ
cord-263157-8jin6oru	331	3	-	-	HYPH
cord-263157-8jin6oru	331	4	nuclear	nuclear	JJ
cord-263157-8jin6oru	331	5	-	-	HYPH
cord-263157-8jin6oru	331	6	envelope	envelope	NN
cord-263157-8jin6oru	331	7	protein	protein	NN
cord-263157-8jin6oru	331	8	emerin	emerin	NNP
cord-263157-8jin6oru	331	9	regulates	regulate	VBZ
cord-263157-8jin6oru	331	10	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	331	11	infectivity	infectivity	NN
cord-263157-8jin6oru	331	12	UnPAKing	UnPAKing	NNP
cord-263157-8jin6oru	331	13	"	"	``
cord-263157-8jin6oru	331	14	human	human	JJ
cord-263157-8jin6oru	331	15	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	331	16	virus	virus	NN
cord-263157-8jin6oru	331	17	(	(	-LRB-
cord-263157-8jin6oru	331	18	HIV	HIV	NNP
cord-263157-8jin6oru	331	19	)	)	-RRB-
cord-263157-8jin6oru	331	20	replication	replication	NN
cord-263157-8jin6oru	331	21	:	:	:
cord-263157-8jin6oru	331	22	using	use	VBG
cord-263157-8jin6oru	331	23	small	small	JJ
cord-263157-8jin6oru	331	24	interfering	interfere	VBG
cord-263157-8jin6oru	331	25	RNA	RNA	NNP
cord-263157-8jin6oru	331	26	screening	screening	NN
cord-263157-8jin6oru	331	27	to	to	TO
cord-263157-8jin6oru	331	28	identify	identify	VB
cord-263157-8jin6oru	331	29	novel	novel	JJ
cord-263157-8jin6oru	331	30	cofactors	cofactor	NNS
cord-263157-8jin6oru	331	31	and	and	CC
cord-263157-8jin6oru	331	32	elucidate	elucidate	VB
cord-263157-8jin6oru	331	33	the	the	DT
cord-263157-8jin6oru	331	34	role	role	NN
cord-263157-8jin6oru	331	35	of	of	IN
cord-263157-8jin6oru	331	36	group	group	NN
cord-263157-8jin6oru	331	37	I	-PRON-	PRP
cord-263157-8jin6oru	331	38	PAKs	paks	VBP
cord-263157-8jin6oru	331	39	in	in	IN
cord-263157-8jin6oru	331	40	HIV	HIV	NNP
cord-263157-8jin6oru	331	41	infection	infection	NN
cord-263157-8jin6oru	331	42	Inhibition	inhibition	NN
cord-263157-8jin6oru	331	43	of	of	IN
cord-263157-8jin6oru	331	44	human	human	JJ
cord-263157-8jin6oru	331	45	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	331	46	virus	virus	NN
cord-263157-8jin6oru	331	47	type	type	NN
cord-263157-8jin6oru	331	48	1	1	CD
cord-263157-8jin6oru	331	49	replication	replication	NN
cord-263157-8jin6oru	331	50	by	by	IN
cord-263157-8jin6oru	331	51	RNA	RNA	NNP
cord-263157-8jin6oru	331	52	interference	interference	NN
cord-263157-8jin6oru	331	53	directed	direct	VBN
cord-263157-8jin6oru	331	54	against	against	IN
cord-263157-8jin6oru	331	55	human	human	JJ
cord-263157-8jin6oru	331	56	transcription	transcription	NN
cord-263157-8jin6oru	331	57	elongation	elongation	NN
cord-263157-8jin6oru	331	58	factor	factor	NN
cord-263157-8jin6oru	331	59	P	p	NN
cord-263157-8jin6oru	331	60	-	-	HYPH
cord-263157-8jin6oru	331	61	TEFb	TEFb	NNP
cord-263157-8jin6oru	331	62	(	(	-LRB-
cord-263157-8jin6oru	331	63	CDK9	CDK9	NNP
cord-263157-8jin6oru	331	64	/	/	SYM
cord-263157-8jin6oru	331	65	CyclinT1	cyclint1	NN
cord-263157-8jin6oru	331	66	)	)	-RRB-
cord-263157-8jin6oru	332	1	Chemokine	chemokine	JJ
cord-263157-8jin6oru	332	2	receptors	receptor	NNS
cord-263157-8jin6oru	332	3	as	as	IN
cord-263157-8jin6oru	332	4	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	332	5	coreceptors	coreceptor	NNS
cord-263157-8jin6oru	332	6	:	:	:
cord-263157-8jin6oru	333	1	roles	role	NNS
cord-263157-8jin6oru	333	2	in	in	IN
cord-263157-8jin6oru	333	3	viral	viral	JJ
cord-263157-8jin6oru	333	4	entry	entry	NN
cord-263157-8jin6oru	333	5	,	,	,
cord-263157-8jin6oru	333	6	tropism	tropism	NN
cord-263157-8jin6oru	333	7	,	,	,
cord-263157-8jin6oru	333	8	and	and	CC
cord-263157-8jin6oru	333	9	disease	disease	NN
cord-263157-8jin6oru	333	10	Stable	stable	JJ
cord-263157-8jin6oru	333	11	reduction	reduction	NN
cord-263157-8jin6oru	333	12	of	of	IN
cord-263157-8jin6oru	333	13	CCR5	CCR5	NNP
cord-263157-8jin6oru	333	14	by	by	IN
cord-263157-8jin6oru	333	15	RNAi	RNAi	NNS
cord-263157-8jin6oru	333	16	through	through	IN
cord-263157-8jin6oru	333	17	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	333	18	stem	stem	NN
cord-263157-8jin6oru	333	19	cell	cell	NN
cord-263157-8jin6oru	333	20	transplant	transplant	NN
cord-263157-8jin6oru	333	21	in	in	IN
cord-263157-8jin6oru	333	22	non	non	JJ
cord-263157-8jin6oru	333	23	-	-	JJ
cord-263157-8jin6oru	333	24	human	human	JJ
cord-263157-8jin6oru	333	25	primates	primate	NNS
cord-263157-8jin6oru	333	26	Interfering	interfere	VBG
cord-263157-8jin6oru	333	27	with	with	IN
cord-263157-8jin6oru	333	28	disease	disease	NN
cord-263157-8jin6oru	333	29	:	:	:
cord-263157-8jin6oru	333	30	a	a	DT
cord-263157-8jin6oru	333	31	progress	progress	NN
cord-263157-8jin6oru	333	32	report	report	NN
cord-263157-8jin6oru	333	33	on	on	IN
cord-263157-8jin6oru	333	34	siRNA	siRNA	NNP
cord-263157-8jin6oru	333	35	-	-	HYPH
cord-263157-8jin6oru	333	36	based	base	VBN
cord-263157-8jin6oru	333	37	therapeutics	therapeutic	NNS
cord-263157-8jin6oru	333	38	Inhibition	inhibition	NN
cord-263157-8jin6oru	333	39	of	of	IN
cord-263157-8jin6oru	333	40	respiratory	respiratory	JJ
cord-263157-8jin6oru	333	41	viruses	virus	NNS
cord-263157-8jin6oru	333	42	by	by	IN
cord-263157-8jin6oru	333	43	nasally	nasally	RB
cord-263157-8jin6oru	333	44	administered	administer	VBN
cord-263157-8jin6oru	333	45	siRNA	siRNA	NNP
cord-263157-8jin6oru	333	46	Using	use	VBG
cord-263157-8jin6oru	333	47	siRNA	siRNA	NNP
cord-263157-8jin6oru	333	48	in	in	IN
cord-263157-8jin6oru	333	49	prophylactic	prophylactic	JJ
cord-263157-8jin6oru	333	50	and	and	CC
cord-263157-8jin6oru	333	51	therapeutic	therapeutic	JJ
cord-263157-8jin6oru	333	52	regimens	regimen	NNS
cord-263157-8jin6oru	333	53	against	against	IN
cord-263157-8jin6oru	333	54	SARS	SARS	NNP
cord-263157-8jin6oru	333	55	coronavirus	coronavirus	NN
cord-263157-8jin6oru	333	56	in	in	IN
cord-263157-8jin6oru	333	57	Rhesus	Rhesus	NNP
cord-263157-8jin6oru	333	58	macaque	macaque	NN
cord-263157-8jin6oru	333	59	Potent	potent	JJ
cord-263157-8jin6oru	333	60	and	and	CC
cord-263157-8jin6oru	333	61	persistent	persistent	JJ
cord-263157-8jin6oru	333	62	in	in	IN
cord-263157-8jin6oru	333	63	vivo	vivo	NNP
cord-263157-8jin6oru	333	64	anti	anti	JJ
cord-263157-8jin6oru	333	65	-	-	JJ
cord-263157-8jin6oru	333	66	HBV	hbv	JJ
cord-263157-8jin6oru	333	67	activity	activity	NN
cord-263157-8jin6oru	333	68	of	of	IN
cord-263157-8jin6oru	333	69	chemically	chemically	RB
cord-263157-8jin6oru	333	70	modified	modify	VBN
cord-263157-8jin6oru	333	71	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	333	72	Postexposure	Postexposure	NNP
cord-263157-8jin6oru	333	73	protection	protection	NN
cord-263157-8jin6oru	333	74	of	of	IN
cord-263157-8jin6oru	333	75	guinea	guinea	NN
cord-263157-8jin6oru	333	76	pigs	pig	NNS
cord-263157-8jin6oru	333	77	against	against	IN
cord-263157-8jin6oru	333	78	a	a	DT
cord-263157-8jin6oru	333	79	lethal	lethal	JJ
cord-263157-8jin6oru	333	80	Ebola	Ebola	NNP
cord-263157-8jin6oru	333	81	virus	virus	NN
cord-263157-8jin6oru	333	82	challenge	challenge	NN
cord-263157-8jin6oru	333	83	is	be	VBZ
cord-263157-8jin6oru	333	84	conferred	confer	VBN
cord-263157-8jin6oru	333	85	by	by	IN
cord-263157-8jin6oru	333	86	RNA	RNA	NNP
cord-263157-8jin6oru	333	87	interference	interference	NN
cord-263157-8jin6oru	334	1	An	an	DT
cord-263157-8jin6oru	334	2	siRNA	sirna	NN
cord-263157-8jin6oru	334	3	-	-	HYPH
cord-263157-8jin6oru	334	4	based	base	VBN
cord-263157-8jin6oru	334	5	microbicide	microbicide	NN
cord-263157-8jin6oru	334	6	protects	protect	VBZ
cord-263157-8jin6oru	334	7	mice	mouse	NNS
cord-263157-8jin6oru	334	8	from	from	IN
cord-263157-8jin6oru	334	9	lethal	lethal	JJ
cord-263157-8jin6oru	334	10	herpes	herpe	NNS
cord-263157-8jin6oru	334	11	simplex	simplex	NN
cord-263157-8jin6oru	334	12	virus	virus	NN
cord-263157-8jin6oru	334	13	2	2	CD
cord-263157-8jin6oru	334	14	infection	infection	NN
cord-263157-8jin6oru	334	15	Peptide	peptide	NN
cord-263157-8jin6oru	334	16	-	-	HYPH
cord-263157-8jin6oru	334	17	oligonucleotide	oligonucleotide	JJ
cord-263157-8jin6oru	334	18	conjugates	conjugate	NNS
cord-263157-8jin6oru	334	19	for	for	IN
cord-263157-8jin6oru	334	20	the	the	DT
cord-263157-8jin6oru	334	21	delivery	delivery	NN
cord-263157-8jin6oru	334	22	of	of	IN
cord-263157-8jin6oru	334	23	antisense	antisense	NNP
cord-263157-8jin6oru	334	24	and	and	CC
cord-263157-8jin6oru	334	25	siRNA	siRNA	NNP
cord-263157-8jin6oru	334	26	Antibody	Antibody	NNP
cord-263157-8jin6oru	334	27	mediated	mediate	VBD
cord-263157-8jin6oru	334	28	in	in	IN
cord-263157-8jin6oru	334	29	vivo	vivo	NN
cord-263157-8jin6oru	334	30	delivery	delivery	NN
cord-263157-8jin6oru	334	31	of	of	IN
cord-263157-8jin6oru	334	32	small	small	JJ
cord-263157-8jin6oru	334	33	interfering	interfere	VBG
cord-263157-8jin6oru	334	34	RNAs	rna	NNS
cord-263157-8jin6oru	334	35	via	via	IN
cord-263157-8jin6oru	334	36	cell	cell	NN
cord-263157-8jin6oru	334	37	-	-	HYPH
cord-263157-8jin6oru	334	38	surface	surface	NN
cord-263157-8jin6oru	334	39	receptors	receptor	NNS
cord-263157-8jin6oru	335	1	In	in	IN
cord-263157-8jin6oru	335	2	vivo	vivo	NN
cord-263157-8jin6oru	335	3	gene	gene	NN
cord-263157-8jin6oru	335	4	delivery	delivery	NN
cord-263157-8jin6oru	335	5	and	and	CC
cord-263157-8jin6oru	335	6	stable	stable	JJ
cord-263157-8jin6oru	335	7	transduction	transduction	NN
cord-263157-8jin6oru	335	8	of	of	IN
cord-263157-8jin6oru	335	9	nondividing	nondivide	VBG
cord-263157-8jin6oru	335	10	cells	cell	NNS
cord-263157-8jin6oru	335	11	by	by	IN
cord-263157-8jin6oru	335	12	a	a	DT
cord-263157-8jin6oru	335	13	lentiviral	lentiviral	JJ
cord-263157-8jin6oru	335	14	vector	vector	NN
cord-263157-8jin6oru	335	15	Lentivirus	Lentivirus	NNP
cord-263157-8jin6oru	335	16	-	-	HYPH
cord-263157-8jin6oru	335	17	mediated	mediate	VBN
cord-263157-8jin6oru	335	18	RNA	RNA	NNP
cord-263157-8jin6oru	335	19	interference	interference	NN
cord-263157-8jin6oru	335	20	therapy	therapy	NN
cord-263157-8jin6oru	335	21	for	for	IN
cord-263157-8jin6oru	335	22	human	human	JJ
cord-263157-8jin6oru	335	23	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	335	24	virus	virus	NN
cord-263157-8jin6oru	335	25	type	type	NN
cord-263157-8jin6oru	335	26	1	1	CD
cord-263157-8jin6oru	335	27	infection	infection	NN
cord-263157-8jin6oru	335	28	Lentiviral	Lentiviral	NNP
cord-263157-8jin6oru	335	29	vectors	vector	NNS
cord-263157-8jin6oru	335	30	that	that	WDT
cord-263157-8jin6oru	335	31	carry	carry	VBP
cord-263157-8jin6oru	335	32	anti	anti	JJ
cord-263157-8jin6oru	335	33	-	-	JJ
cord-263157-8jin6oru	335	34	HIV	HIV	NNP
cord-263157-8jin6oru	335	35	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	335	36	:	:	:
cord-263157-8jin6oru	335	37	problems	problem	NNS
cord-263157-8jin6oru	335	38	and	and	CC
cord-263157-8jin6oru	335	39	solutions	solution	NNS
cord-263157-8jin6oru	335	40	Development	Development	NNP
cord-263157-8jin6oru	335	41	of	of	IN
cord-263157-8jin6oru	335	42	an	an	DT
cord-263157-8jin6oru	335	43	RNAi	RNAi	NNP
cord-263157-8jin6oru	335	44	based	base	VBN
cord-263157-8jin6oru	335	45	gene	gene	NN
cord-263157-8jin6oru	335	46	therapy	therapy	NN
cord-263157-8jin6oru	335	47	against	against	IN
cord-263157-8jin6oru	335	48	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	335	49	.	.	.
cord-263157-8jin6oru	336	1	Amsterdam	Amsterdam	NNP
cord-263157-8jin6oru	336	2	:	:	:
cord-263157-8jin6oru	337	1	Doctoral	Doctoral	NNP
cord-263157-8jin6oru	337	2	Thesis	Thesis	NNP
cord-263157-8jin6oru	337	3	Endogenous	Endogenous	NNP
cord-263157-8jin6oru	337	4	microRNA	microRNA	NNP
cord-263157-8jin6oru	337	5	regulation	regulation	NN
cord-263157-8jin6oru	337	6	suppresses	suppress	VBZ
cord-263157-8jin6oru	337	7	transgene	transgene	JJ
cord-263157-8jin6oru	337	8	expression	expression	NN
cord-263157-8jin6oru	337	9	in	in	IN
cord-263157-8jin6oru	337	10	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	337	11	lineages	lineage	NNS
cord-263157-8jin6oru	337	12	and	and	CC
cord-263157-8jin6oru	337	13	enables	enable	VBZ
cord-263157-8jin6oru	337	14	stable	stable	JJ
cord-263157-8jin6oru	337	15	gene	gene	NN
cord-263157-8jin6oru	337	16	transfer	transfer	NN
cord-263157-8jin6oru	337	17	Transcription	transcription	NN
cord-263157-8jin6oru	337	18	start	start	NN
cord-263157-8jin6oru	337	19	regions	region	NNS
cord-263157-8jin6oru	337	20	in	in	IN
cord-263157-8jin6oru	337	21	the	the	DT
cord-263157-8jin6oru	337	22	human	human	JJ
cord-263157-8jin6oru	337	23	genome	genome	NN
cord-263157-8jin6oru	337	24	are	be	VBP
cord-263157-8jin6oru	337	25	favored	favor	VBN
cord-263157-8jin6oru	337	26	targets	target	NNS
cord-263157-8jin6oru	337	27	for	for	IN
cord-263157-8jin6oru	337	28	MLV	MLV	NNP
cord-263157-8jin6oru	337	29	integration	integration	NN
cord-263157-8jin6oru	338	1	A	a	DT
cord-263157-8jin6oru	338	2	serious	serious	JJ
cord-263157-8jin6oru	338	3	adverse	adverse	JJ
cord-263157-8jin6oru	338	4	event	event	NN
cord-263157-8jin6oru	338	5	after	after	IN
cord-263157-8jin6oru	338	6	successful	successful	JJ
cord-263157-8jin6oru	338	7	gene	gene	NN
cord-263157-8jin6oru	338	8	therapy	therapy	NN
cord-263157-8jin6oru	338	9	for	for	IN
cord-263157-8jin6oru	338	10	X	x	NN
cord-263157-8jin6oru	338	11	-	-	HYPH
cord-263157-8jin6oru	338	12	linked	link	VBN
cord-263157-8jin6oru	338	13	severe	severe	JJ
cord-263157-8jin6oru	338	14	combined	combine	VBN
cord-263157-8jin6oru	338	15	immunodeficiency	immunodeficiency	NN
cord-263157-8jin6oru	338	16	Insertional	Insertional	NNP
cord-263157-8jin6oru	338	17	mutagenesis	mutagenesis	NN
cord-263157-8jin6oru	338	18	in	in	IN
cord-263157-8jin6oru	338	19	gene	gene	NN
cord-263157-8jin6oru	338	20	therapy	therapy	NN
cord-263157-8jin6oru	338	21	and	and	CC
cord-263157-8jin6oru	338	22	stem	stem	NN
cord-263157-8jin6oru	338	23	cell	cell	NN
cord-263157-8jin6oru	338	24	biology	biology	NN
cord-263157-8jin6oru	338	25	Retroviral	retroviral	NN
cord-263157-8jin6oru	338	26	vector	vector	NN
cord-263157-8jin6oru	338	27	insertion	insertion	NN
cord-263157-8jin6oru	338	28	sites	site	NNS
cord-263157-8jin6oru	338	29	associated	associate	VBN
cord-263157-8jin6oru	338	30	with	with	IN
cord-263157-8jin6oru	338	31	dominant	dominant	JJ
cord-263157-8jin6oru	338	32	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	338	33	clones	clone	NNS
cord-263157-8jin6oru	339	1	mark	mark	NNP
cord-263157-8jin6oru	339	2	"	"	``
cord-263157-8jin6oru	339	3	stemness	stemness	NNP
cord-263157-8jin6oru	339	4	Gene	Gene	NNP
cord-263157-8jin6oru	339	5	therapy	therapy	NN
cord-263157-8jin6oru	339	6	targeting	target	VBG
cord-263157-8jin6oru	339	7	peripheral	peripheral	JJ
cord-263157-8jin6oru	339	8	blood	blood	NN
cord-263157-8jin6oru	339	9	CD34	CD34	NNP
cord-263157-8jin6oru	339	10	+	+	CC
cord-263157-8jin6oru	339	11	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	339	12	stem	stem	NN
cord-263157-8jin6oru	339	13	cells	cell	NNS
cord-263157-8jin6oru	339	14	of	of	IN
cord-263157-8jin6oru	339	15	HIV	HIV	NNP
cord-263157-8jin6oru	339	16	-	-	HYPH
cord-263157-8jin6oru	339	17	infected	infect	VBN
cord-263157-8jin6oru	339	18	individuals	individual	NNS
cord-263157-8jin6oru	339	19	Design	Design	NNP
cord-263157-8jin6oru	339	20	of	of	IN
cord-263157-8jin6oru	339	21	HIV	HIV	NNP
cord-263157-8jin6oru	339	22	vectors	vector	NNS
cord-263157-8jin6oru	339	23	for	for	IN
cord-263157-8jin6oru	339	24	efficient	efficient	JJ
cord-263157-8jin6oru	339	25	gene	gene	NN
cord-263157-8jin6oru	339	26	delivery	delivery	NN
cord-263157-8jin6oru	339	27	into	into	IN
cord-263157-8jin6oru	339	28	human	human	JJ
cord-263157-8jin6oru	339	29	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	339	30	cells	cell	NNS
cord-263157-8jin6oru	339	31	Transduction	transduction	NN
cord-263157-8jin6oru	339	32	of	of	IN
cord-263157-8jin6oru	339	33	cell	cell	NN
cord-263157-8jin6oru	339	34	lines	line	NNS
cord-263157-8jin6oru	339	35	and	and	CC
cord-263157-8jin6oru	339	36	primary	primary	JJ
cord-263157-8jin6oru	339	37	cells	cell	NNS
cord-263157-8jin6oru	339	38	by	by	IN
cord-263157-8jin6oru	339	39	FIV	fiv	NN
cord-263157-8jin6oru	339	40	-	-	HYPH
cord-263157-8jin6oru	339	41	packaged	package	VBN
cord-263157-8jin6oru	339	42	HIV	HIV	NNP
cord-263157-8jin6oru	339	43	vectors	vector	NNS
cord-263157-8jin6oru	339	44	RNA	RNA	NNP
cord-263157-8jin6oru	339	45	interference	interference	NN
cord-263157-8jin6oru	339	46	and	and	CC
cord-263157-8jin6oru	339	47	innate	innate	JJ
cord-263157-8jin6oru	339	48	immunity	immunity	NN
cord-263157-8jin6oru	339	49	Sequence	sequence	NN
cord-263157-8jin6oru	339	50	-	-	HYPH
cord-263157-8jin6oru	339	51	dependent	dependent	JJ
cord-263157-8jin6oru	339	52	stimulation	stimulation	NN
cord-263157-8jin6oru	339	53	of	of	IN
cord-263157-8jin6oru	339	54	the	the	DT
cord-263157-8jin6oru	339	55	mammalian	mammalian	JJ
cord-263157-8jin6oru	339	56	innate	innate	JJ
cord-263157-8jin6oru	339	57	immune	immune	JJ
cord-263157-8jin6oru	339	58	response	response	NN
cord-263157-8jin6oru	339	59	by	by	IN
cord-263157-8jin6oru	339	60	synthetic	synthetic	JJ
cord-263157-8jin6oru	339	61	siRNA	siRNA	NNP
cord-263157-8jin6oru	339	62	Cationic	Cationic	NNP
cord-263157-8jin6oru	339	63	liposome	liposome	NN
cord-263157-8jin6oru	339	64	-	-	HYPH
cord-263157-8jin6oru	339	65	mediated	mediate	VBN
cord-263157-8jin6oru	339	66	delivery	delivery	NN
cord-263157-8jin6oru	339	67	of	of	IN
cord-263157-8jin6oru	339	68	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	339	69	in	in	IN
cord-263157-8jin6oru	339	70	adult	adult	NN
cord-263157-8jin6oru	339	71	mice	mouse	NNS
cord-263157-8jin6oru	339	72	siRNA	siRNA	NNP
cord-263157-8jin6oru	339	73	function	function	NN
cord-263157-8jin6oru	339	74	in	in	IN
cord-263157-8jin6oru	339	75	RNAi	RNAi	NNP
cord-263157-8jin6oru	339	76	:	:	:
cord-263157-8jin6oru	339	77	A	a	DT
cord-263157-8jin6oru	339	78	chemical	chemical	JJ
cord-263157-8jin6oru	339	79	modification	modification	NN
cord-263157-8jin6oru	339	80	analysis	analysis	NN
cord-263157-8jin6oru	339	81	vivo	vivo	NN
cord-263157-8jin6oru	339	82	activity	activity	NN
cord-263157-8jin6oru	339	83	of	of	IN
cord-263157-8jin6oru	339	84	nuclease	nuclease	NN
cord-263157-8jin6oru	339	85	-	-	HYPH
cord-263157-8jin6oru	339	86	resistant	resistant	JJ
cord-263157-8jin6oru	339	87	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	339	88	Single	Single	NNP
cord-263157-8jin6oru	339	89	-	-	HYPH
cord-263157-8jin6oru	339	90	stranded	strand	VBN
cord-263157-8jin6oru	339	91	small	small	JJ
cord-263157-8jin6oru	339	92	interfering	interfere	VBG
cord-263157-8jin6oru	339	93	RNA	RNA	NNP
cord-263157-8jin6oru	339	94	are	be	VBP
cord-263157-8jin6oru	339	95	more	more	RBR
cord-263157-8jin6oru	339	96	immunostimulatory	immunostimulatory	NN
cord-263157-8jin6oru	339	97	than	than	IN
cord-263157-8jin6oru	339	98	their	-PRON-	PRP$
cord-263157-8jin6oru	339	99	double	double	JJ
cord-263157-8jin6oru	339	100	-	-	HYPH
cord-263157-8jin6oru	339	101	stranded	strand	VBN
cord-263157-8jin6oru	339	102	counterparts	counterpart	NNS
cord-263157-8jin6oru	339	103	:	:	:
cord-263157-8jin6oru	339	104	a	a	DT
cord-263157-8jin6oru	339	105	central	central	JJ
cord-263157-8jin6oru	339	106	role	role	NN
cord-263157-8jin6oru	339	107	for	for	IN
cord-263157-8jin6oru	339	108	2	2	CD
cord-263157-8jin6oru	339	109	′	′	CD
cord-263157-8jin6oru	339	110	-hydroxyl	-hydroxyl	CD
cord-263157-8jin6oru	339	111	uridines	uridine	NNS
cord-263157-8jin6oru	339	112	in	in	IN
cord-263157-8jin6oru	339	113	immune	immune	JJ
cord-263157-8jin6oru	339	114	responses	response	NNS
cord-263157-8jin6oru	339	115	On	on	IN
cord-263157-8jin6oru	339	116	the	the	DT
cord-263157-8jin6oru	339	117	delivery	delivery	NN
cord-263157-8jin6oru	339	118	of	of	IN
cord-263157-8jin6oru	339	119	small	small	JJ
cord-263157-8jin6oru	339	120	interfering	interfere	VBG
cord-263157-8jin6oru	339	121	RNAs	rna	NNS
cord-263157-8jin6oru	339	122	into	into	IN
cord-263157-8jin6oru	339	123	mammalian	mammalian	JJ
cord-263157-8jin6oru	339	124	cells	cell	NNS
cord-263157-8jin6oru	340	1	Small	small	JJ
cord-263157-8jin6oru	340	2	interfering	interfere	VBG
cord-263157-8jin6oru	340	3	RNAs	rna	NNS
cord-263157-8jin6oru	340	4	mediate	mediate	VBP
cord-263157-8jin6oru	340	5	sequence	sequence	NN
cord-263157-8jin6oru	340	6	-	-	HYPH
cord-263157-8jin6oru	340	7	independent	independent	JJ
cord-263157-8jin6oru	340	8	gene	gene	NN
cord-263157-8jin6oru	340	9	suppression	suppression	NN
cord-263157-8jin6oru	340	10	and	and	CC
cord-263157-8jin6oru	340	11	induce	induce	VB
cord-263157-8jin6oru	340	12	immune	immune	JJ
cord-263157-8jin6oru	340	13	activation	activation	NN
cord-263157-8jin6oru	340	14	by	by	IN
cord-263157-8jin6oru	340	15	signaling	signal	VBG
cord-263157-8jin6oru	340	16	through	through	IN
cord-263157-8jin6oru	340	17	toll	toll	NN
cord-263157-8jin6oru	340	18	-	-	HYPH
cord-263157-8jin6oru	340	19	like	like	JJ
cord-263157-8jin6oru	340	20	receptor	receptor	NN
cord-263157-8jin6oru	340	21	3	3	CD
cord-263157-8jin6oru	340	22	Stable	stable	JJ
cord-263157-8jin6oru	340	23	expression	expression	NN
cord-263157-8jin6oru	340	24	of	of	IN
cord-263157-8jin6oru	340	25	shRNAs	shRNAs	NNP
cord-263157-8jin6oru	340	26	in	in	IN
cord-263157-8jin6oru	340	27	human	human	JJ
cord-263157-8jin6oru	340	28	CD34	CD34	NNP
cord-263157-8jin6oru	341	1	+	+	CC
cord-263157-8jin6oru	341	2	progenitor	progenitor	NN
cord-263157-8jin6oru	341	3	cells	cell	NNS
cord-263157-8jin6oru	341	4	can	can	MD
cord-263157-8jin6oru	341	5	avoid	avoid	VB
cord-263157-8jin6oru	341	6	induction	induction	NN
cord-263157-8jin6oru	341	7	of	of	IN
cord-263157-8jin6oru	341	8	interferon	interferon	NN
cord-263157-8jin6oru	341	9	responses	response	NNS
cord-263157-8jin6oru	341	10	to	to	IN
cord-263157-8jin6oru	341	11	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	341	12	in	in	IN
cord-263157-8jin6oru	341	13	vitro	vitro	FW
cord-263157-8jin6oru	341	14	Trans	Trans	NNP
cord-263157-8jin6oru	341	15	-	-	NN
cord-263157-8jin6oru	341	16	inhibition	inhibition	NN
cord-263157-8jin6oru	341	17	of	of	IN
cord-263157-8jin6oru	341	18	HIV-1	HIV-1	NNP
cord-263157-8jin6oru	341	19	by	by	IN
cord-263157-8jin6oru	341	20	a	a	DT
cord-263157-8jin6oru	341	21	long	long	JJ
cord-263157-8jin6oru	341	22	hairpin	hairpin	NN
cord-263157-8jin6oru	341	23	RNA	RNA	NNP
cord-263157-8jin6oru	341	24	expressed	express	VBD
cord-263157-8jin6oru	341	25	within	within	IN
cord-263157-8jin6oru	341	26	the	the	DT
cord-263157-8jin6oru	341	27	viral	viral	JJ
cord-263157-8jin6oru	341	28	genome	genome	NN
cord-263157-8jin6oru	341	29	Intracellular	Intracellular	NNP
cord-263157-8jin6oru	341	30	-	-	HYPH
cord-263157-8jin6oru	341	31	diced	dice	VBN
cord-263157-8jin6oru	341	32	dsRNA	dsrna	NN
cord-263157-8jin6oru	342	1	has	have	VBZ
cord-263157-8jin6oru	342	2	enhanced	enhance	VBN
cord-263157-8jin6oru	342	3	efficacy	efficacy	NN
cord-263157-8jin6oru	342	4	for	for	IN
cord-263157-8jin6oru	342	5	silencing	silence	VBG
cord-263157-8jin6oru	342	6	HCV	HCV	NNP
cord-263157-8jin6oru	342	7	RNA	RNA	NNP
cord-263157-8jin6oru	342	8	and	and	CC
cord-263157-8jin6oru	342	9	overcomes	overcome	VBZ
cord-263157-8jin6oru	342	10	variation	variation	NN
cord-263157-8jin6oru	342	11	in	in	IN
cord-263157-8jin6oru	342	12	the	the	DT
cord-263157-8jin6oru	342	13	viral	viral	JJ
cord-263157-8jin6oru	342	14	genotype	genotype	NN
cord-263157-8jin6oru	342	15	Effective	effective	JJ
cord-263157-8jin6oru	342	16	anti	anti	JJ
cord-263157-8jin6oru	342	17	-	-	JJ
cord-263157-8jin6oru	342	18	hepatitis	hepatitis	JJ
cord-263157-8jin6oru	342	19	B	b	NN
cord-263157-8jin6oru	342	20	virus	virus	NN
cord-263157-8jin6oru	342	21	hammerhead	hammerhead	NN
cord-263157-8jin6oru	342	22	ribozymes	ribozyme	NNS
cord-263157-8jin6oru	342	23	derived	derive	VBN
cord-263157-8jin6oru	342	24	from	from	IN
cord-263157-8jin6oru	342	25	multimeric	multimeric	JJ
cord-263157-8jin6oru	342	26	precursors	precursor	NNS
cord-263157-8jin6oru	342	27	MicroRNAs	MicroRNAs	NNPS
cord-263157-8jin6oru	342	28	modulate	modulate	VBP
cord-263157-8jin6oru	342	29	hematopoietic	hematopoietic	JJ
cord-263157-8jin6oru	342	30	lineage	lineage	NN
cord-263157-8jin6oru	342	31	differentiation	differentiation	NN
cord-263157-8jin6oru	342	32	Effective	effective	JJ
cord-263157-8jin6oru	342	33	RNAi	RNAi	NNS
cord-263157-8jin6oru	342	34	-	-	HYPH
cord-263157-8jin6oru	342	35	mediated	mediate	VBN
cord-263157-8jin6oru	342	36	gene	gene	NN
cord-263157-8jin6oru	342	37	silencing	silencing	NN
cord-263157-8jin6oru	342	38	without	without	IN
cord-263157-8jin6oru	342	39	interruption	interruption	NN
cord-263157-8jin6oru	342	40	of	of	IN
cord-263157-8jin6oru	342	41	the	the	DT
cord-263157-8jin6oru	342	42	endogenous	endogenous	JJ
cord-263157-8jin6oru	342	43	microRNA	microRNA	NNP
cord-263157-8jin6oru	342	44	pathway	pathway	NNP
cord-263157-8jin6oru	342	45	Expression	Expression	NNP
cord-263157-8jin6oru	342	46	profiling	profiling	NN
cord-263157-8jin6oru	342	47	reveals	reveal	VBZ
cord-263157-8jin6oru	342	48	off	off	IN
cord-263157-8jin6oru	342	49	-	-	HYPH
cord-263157-8jin6oru	342	50	target	target	NN
cord-263157-8jin6oru	342	51	gene	gene	NN
cord-263157-8jin6oru	342	52	regulation	regulation	NN
cord-263157-8jin6oru	342	53	by	by	IN
cord-263157-8jin6oru	342	54	RNAi	RNAi	NNP
cord-263157-8jin6oru	342	55	Widespread	Widespread	NNP
cord-263157-8jin6oru	342	56	siRNA	siRNA	NNP
cord-263157-8jin6oru	343	1	"	"	``
cord-263157-8jin6oru	343	2	off	off	IN
cord-263157-8jin6oru	343	3	-	-	HYPH
cord-263157-8jin6oru	343	4	target	target	NN
cord-263157-8jin6oru	343	5	"	"	''
cord-263157-8jin6oru	343	6	transcript	transcript	NN
cord-263157-8jin6oru	343	7	silencing	silence	VBG
cord-263157-8jin6oru	343	8	mediated	mediate	VBN
cord-263157-8jin6oru	343	9	by	by	IN
cord-263157-8jin6oru	343	10	seed	seed	NN
cord-263157-8jin6oru	343	11	region	region	NN
cord-263157-8jin6oru	343	12	sequence	sequence	NN
cord-263157-8jin6oru	343	13	complementarity	complementarity	NN
cord-263157-8jin6oru	343	14	3	3	CD
cord-263157-8jin6oru	343	15	′	′	CD
cord-263157-8jin6oru	344	1	UTR	UTR	NNP
cord-263157-8jin6oru	344	2	seed	seed	NN
cord-263157-8jin6oru	344	3	matches	match	NNS
cord-263157-8jin6oru	344	4	,	,	,
cord-263157-8jin6oru	344	5	but	but	CC
cord-263157-8jin6oru	344	6	not	not	RB
cord-263157-8jin6oru	344	7	overall	overall	JJ
cord-263157-8jin6oru	344	8	identity	identity	NN
cord-263157-8jin6oru	344	9	,	,	,
cord-263157-8jin6oru	344	10	are	be	VBP
cord-263157-8jin6oru	344	11	associated	associate	VBN
cord-263157-8jin6oru	344	12	with	with	IN
cord-263157-8jin6oru	344	13	RNAi	RNAi	NNS
cord-263157-8jin6oru	344	14	off	off	IN
cord-263157-8jin6oru	344	15	-	-	HYPH
cord-263157-8jin6oru	344	16	targets	target	NNS
cord-263157-8jin6oru	345	1	siRNA	siRNA	NNP
cord-263157-8jin6oru	345	2	-	-	HYPH
cord-263157-8jin6oru	345	3	mediated	mediate	VBN
cord-263157-8jin6oru	345	4	off	off	IN
cord-263157-8jin6oru	345	5	-	-	HYPH
cord-263157-8jin6oru	345	6	target	target	NN
cord-263157-8jin6oru	345	7	gene	gene	NN
cord-263157-8jin6oru	345	8	silencing	silencing	NN
cord-263157-8jin6oru	345	9	triggered	trigger	VBN
cord-263157-8jin6oru	345	10	by	by	IN
cord-263157-8jin6oru	345	11	a	a	DT
cord-263157-8jin6oru	345	12	7	7	CD
cord-263157-8jin6oru	345	13	nt	nt	NN
cord-263157-8jin6oru	345	14	complementation	complementation	NN
cord-263157-8jin6oru	345	15	Gene	Gene	NNP
cord-263157-8jin6oru	345	16	expression	expression	NN
cord-263157-8jin6oru	345	17	analysis	analysis	NN
cord-263157-8jin6oru	345	18	in	in	IN
cord-263157-8jin6oru	345	19	blood	blood	NN
cord-263157-8jin6oru	345	20	cells	cell	NNS
cord-263157-8jin6oru	345	21	in	in	IN
cord-263157-8jin6oru	345	22	response	response	NN
cord-263157-8jin6oru	345	23	to	to	IN
cord-263157-8jin6oru	345	24	unmodified	unmodified	JJ
cord-263157-8jin6oru	345	25	and	and	CC
cord-263157-8jin6oru	345	26	2	2	CD
cord-263157-8jin6oru	345	27	′	′	CD
cord-263157-8jin6oru	346	1	-modified	-modified	NNP
cord-263157-8jin6oru	346	2	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	346	3	reveals	reveal	VBZ
cord-263157-8jin6oru	346	4	TLR	TLR	NNP
cord-263157-8jin6oru	346	5	-	-	HYPH
cord-263157-8jin6oru	346	6	dependent	dependent	JJ
cord-263157-8jin6oru	346	7	and	and	CC
cord-263157-8jin6oru	346	8	independent	independent	JJ
cord-263157-8jin6oru	346	9	effects	effect	NNS
cord-263157-8jin6oru	346	10	Position	position	NN
cord-263157-8jin6oru	346	11	-	-	HYPH
cord-263157-8jin6oru	346	12	specific	specific	JJ
cord-263157-8jin6oru	346	13	chemical	chemical	NN
cord-263157-8jin6oru	346	14	modification	modification	NN
cord-263157-8jin6oru	346	15	of	of	IN
cord-263157-8jin6oru	346	16	siRNAs	siRNAs	NNP
cord-263157-8jin6oru	346	17	reduces	reduce	VBZ
cord-263157-8jin6oru	346	18	"	"	``
cord-263157-8jin6oru	346	19	off	off	IN
cord-263157-8jin6oru	346	20	-	-	HYPH
cord-263157-8jin6oru	346	21	target	target	NN
cord-263157-8jin6oru	346	22	"	"	''
cord-263157-8jin6oru	346	23	transcript	transcript	NN
cord-263157-8jin6oru	346	24	silencing	silence	VBG
cord-263157-8jin6oru	346	25	Monitoring	monitor	VBG
cord-263157-8jin6oru	346	26	the	the	DT
cord-263157-8jin6oru	346	27	effect	effect	NN
cord-263157-8jin6oru	346	28	of	of	IN
cord-263157-8jin6oru	346	29	gene	gene	NN
cord-263157-8jin6oru	346	30	silencing	silencing	NN
cord-263157-8jin6oru	346	31	by	by	IN
cord-263157-8jin6oru	346	32	RNA	RNA	NNP
cord-263157-8jin6oru	346	33	interference	interference	NN
cord-263157-8jin6oru	346	34	in	in	IN
cord-263157-8jin6oru	346	35	human	human	JJ
cord-263157-8jin6oru	346	36	CD34	CD34	NNP
cord-263157-8jin6oru	346	37	+	+	CC
cord-263157-8jin6oru	346	38	cells	cell	NNS
cord-263157-8jin6oru	346	39	injected	inject	VBN
cord-263157-8jin6oru	346	40	into	into	IN
cord-263157-8jin6oru	346	41	newborn	newborn	JJ
cord-263157-8jin6oru	346	42	RAG2−/−	RAG2−/−	NNS
cord-263157-8jin6oru	346	43	gammac−/−	gammac−/−	NN
cord-263157-8jin6oru	346	44	mice	mouse	NNS
cord-263157-8jin6oru	346	45	:	:	:
cord-263157-8jin6oru	346	46	functional	functional	JJ
cord-263157-8jin6oru	346	47	inactivation	inactivation	NN
cord-263157-8jin6oru	346	48	of	of	IN
cord-263157-8jin6oru	346	49	p53	p53	NN
cord-263157-8jin6oru	346	50	in	in	IN
cord-263157-8jin6oru	346	51	developing	develop	VBG
cord-263157-8jin6oru	346	52	T	T	NNP
cord-263157-8jin6oru	346	53	cells	cell	NNS
cord-263157-8jin6oru	346	54	Experimental	experimental	JJ
cord-263157-8jin6oru	346	55	models	model	NNS
cord-263157-8jin6oru	346	56	to	to	TO
cord-263157-8jin6oru	346	57	study	study	VB
cord-263157-8jin6oru	346	58	development	development	NN
cord-263157-8jin6oru	346	59	and	and	CC
cord-263157-8jin6oru	346	60	function	function	NN
cord-263157-8jin6oru	346	61	of	of	IN
cord-263157-8jin6oru	346	62	the	the	DT
cord-263157-8jin6oru	346	63	human	human	JJ
cord-263157-8jin6oru	346	64	immune	immune	JJ
cord-263157-8jin6oru	346	65	system	system	NN
cord-263157-8jin6oru	346	66	in	in	IN
cord-263157-8jin6oru	347	1	vivo	vivo	NNP
cord-263157-8jin6oru	347	2	Disseminated	disseminate	VBN
cord-263157-8jin6oru	347	3	and	and	CC
cord-263157-8jin6oru	347	4	sustained	sustain	VBD
cord-263157-8jin6oru	347	5	HIV	HIV	NNP
cord-263157-8jin6oru	347	6	infection	infection	NN
cord-263157-8jin6oru	347	7	in	in	IN
cord-263157-8jin6oru	347	8	CD34	CD34	NNP
cord-263157-8jin6oru	347	9	+	+	CC
cord-263157-8jin6oru	348	1	cord	cord	NN
cord-263157-8jin6oru	348	2	blood	blood	NN
cord-263157-8jin6oru	348	3	cell	cell	NN
cord-263157-8jin6oru	348	4	-	-	HYPH
cord-263157-8jin6oru	348	5	transplanted	transplant	VBN
cord-263157-8jin6oru	348	6	Rag2−/−gamma	Rag2−/−gamma	NNP
cord-263157-8jin6oru	348	7	c−/−	c−/−	NN
cord-263157-8jin6oru	348	8	mice	mouse	NNS