id	sid	tid	token	lemma	pos
cord-260476-whfyczcj	1	1	key	key	NNP
cord-260476-whfyczcj	1	2	:	:	:
cord-260476-whfyczcj	1	3	cord-260476-whfyczcj	cord-260476-whfyczcj	DT
cord-260476-whfyczcj	2	1	authors	author	NNS
cord-260476-whfyczcj	2	2	:	:	:
cord-260476-whfyczcj	2	3	Seissler	Seissler	NNP
cord-260476-whfyczcj	2	4	,	,	,
cord-260476-whfyczcj	2	5	Tanja	Tanja	NNP
cord-260476-whfyczcj	2	6	;	;	:
cord-260476-whfyczcj	2	7	Marquet	Marquet	NNP
cord-260476-whfyczcj	2	8	,	,	,
cord-260476-whfyczcj	2	9	Roland	Roland	NNP
cord-260476-whfyczcj	2	10	;	;	:
cord-260476-whfyczcj	2	11	Paillart	Paillart	NNP
cord-260476-whfyczcj	2	12	,	,	,
cord-260476-whfyczcj	2	13	Jean	Jean	NNP
cord-260476-whfyczcj	2	14	-	-	HYPH
cord-260476-whfyczcj	2	15	Christophe	Christophe	NNP
cord-260476-whfyczcj	3	1	title	title	NN
cord-260476-whfyczcj	3	2	:	:	:
cord-260476-whfyczcj	3	3	Hijacking	hijacking	NN
cord-260476-whfyczcj	3	4	of	of	IN
cord-260476-whfyczcj	3	5	the	the	DT
cord-260476-whfyczcj	3	6	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	3	7	/	/	SYM
cord-260476-whfyczcj	3	8	Proteasome	Proteasome	NNP
cord-260476-whfyczcj	3	9	Pathway	Pathway	NNP
cord-260476-whfyczcj	3	10	by	by	IN
cord-260476-whfyczcj	3	11	the	the	DT
cord-260476-whfyczcj	3	12	HIV	HIV	NNP
cord-260476-whfyczcj	3	13	Auxiliary	Auxiliary	NNP
cord-260476-whfyczcj	3	14	Proteins	Proteins	NNP
cord-260476-whfyczcj	3	15	date	date	NN
cord-260476-whfyczcj	3	16	:	:	:
cord-260476-whfyczcj	3	17	2017	2017	CD
cord-260476-whfyczcj	3	18	-	-	SYM
cord-260476-whfyczcj	3	19	10	10	CD
cord-260476-whfyczcj	3	20	-	-	SYM
cord-260476-whfyczcj	3	21	31	31	CD
cord-260476-whfyczcj	3	22	journal	journal	NN
cord-260476-whfyczcj	3	23	:	:	:
cord-260476-whfyczcj	4	1	Viruses	virus	NNS
cord-260476-whfyczcj	4	2	DOI	DOI	NNP
cord-260476-whfyczcj	4	3	:	:	:
cord-260476-whfyczcj	5	1	10.3390	10.3390	CD
cord-260476-whfyczcj	6	1	/v9110322	/v9110322	.
cord-260476-whfyczcj	6	2	sha	sha	NNP
cord-260476-whfyczcj	6	3	:	:	:
cord-260476-whfyczcj	7	1	f6fdeab5faa3141b4d0ba262210e6662a7aa261a	f6fdeab5faa3141b4d0ba262210e6662a7aa261a	:
cord-260476-whfyczcj	8	1	doc_id	doc_id	CD
cord-260476-whfyczcj	9	1	:	:	:
cord-260476-whfyczcj	9	2	260476	260476	CD
cord-260476-whfyczcj	9	3	cord_uid	cord_uid	NNS
cord-260476-whfyczcj	9	4	:	:	:
cord-260476-whfyczcj	9	5	whfyczcj	whfyczcj	NNP
cord-260476-whfyczcj	10	1	The	the	DT
cord-260476-whfyczcj	10	2	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	10	3	-	-	HYPH
cord-260476-whfyczcj	10	4	proteasome	proteasome	VBN
cord-260476-whfyczcj	10	5	system	system	NN
cord-260476-whfyczcj	10	6	(	(	-LRB-
cord-260476-whfyczcj	10	7	UPS	UPS	NNP
cord-260476-whfyczcj	10	8	)	)	-RRB-
cord-260476-whfyczcj	10	9	ensures	ensure	VBZ
cord-260476-whfyczcj	10	10	regulation	regulation	NN
cord-260476-whfyczcj	10	11	of	of	IN
cord-260476-whfyczcj	10	12	the	the	DT
cord-260476-whfyczcj	10	13	protein	protein	NN
cord-260476-whfyczcj	10	14	pool	pool	NN
cord-260476-whfyczcj	10	15	in	in	IN
cord-260476-whfyczcj	10	16	the	the	DT
cord-260476-whfyczcj	10	17	cell	cell	NN
cord-260476-whfyczcj	10	18	by	by	IN
cord-260476-whfyczcj	10	19	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	10	20	of	of	IN
cord-260476-whfyczcj	10	21	proteins	protein	NNS
cord-260476-whfyczcj	10	22	followed	follow	VBN
cord-260476-whfyczcj	10	23	by	by	IN
cord-260476-whfyczcj	10	24	their	-PRON-	PRP$
cord-260476-whfyczcj	10	25	degradation	degradation	NN
cord-260476-whfyczcj	10	26	by	by	IN
cord-260476-whfyczcj	10	27	the	the	DT
cord-260476-whfyczcj	10	28	proteasome	proteasome	NN
cord-260476-whfyczcj	10	29	.	.	.
cord-260476-whfyczcj	11	1	It	-PRON-	PRP
cord-260476-whfyczcj	11	2	plays	play	VBZ
cord-260476-whfyczcj	11	3	a	a	DT
cord-260476-whfyczcj	11	4	central	central	JJ
cord-260476-whfyczcj	11	5	role	role	NN
cord-260476-whfyczcj	11	6	in	in	IN
cord-260476-whfyczcj	11	7	the	the	DT
cord-260476-whfyczcj	11	8	cell	cell	NN
cord-260476-whfyczcj	11	9	under	under	IN
cord-260476-whfyczcj	11	10	normal	normal	JJ
cord-260476-whfyczcj	11	11	physiological	physiological	JJ
cord-260476-whfyczcj	11	12	conditions	condition	NNS
cord-260476-whfyczcj	11	13	as	as	RB
cord-260476-whfyczcj	11	14	well	well	RB
cord-260476-whfyczcj	11	15	as	as	IN
cord-260476-whfyczcj	11	16	during	during	IN
cord-260476-whfyczcj	11	17	viral	viral	JJ
cord-260476-whfyczcj	11	18	infections	infection	NNS
cord-260476-whfyczcj	11	19	.	.	.
cord-260476-whfyczcj	12	1	On	on	IN
cord-260476-whfyczcj	12	2	the	the	DT
cord-260476-whfyczcj	12	3	one	one	CD
cord-260476-whfyczcj	12	4	hand	hand	NN
cord-260476-whfyczcj	12	5	,	,	,
cord-260476-whfyczcj	12	6	the	the	DT
cord-260476-whfyczcj	12	7	UPS	UPS	NNPS
cord-260476-whfyczcj	12	8	can	can	MD
cord-260476-whfyczcj	12	9	be	be	VB
cord-260476-whfyczcj	12	10	used	use	VBN
cord-260476-whfyczcj	12	11	by	by	IN
cord-260476-whfyczcj	12	12	the	the	DT
cord-260476-whfyczcj	12	13	cell	cell	NN
cord-260476-whfyczcj	12	14	to	to	TO
cord-260476-whfyczcj	12	15	degrade	degrade	VB
cord-260476-whfyczcj	12	16	viral	viral	JJ
cord-260476-whfyczcj	12	17	proteins	protein	NNS
cord-260476-whfyczcj	12	18	,	,	,
cord-260476-whfyczcj	12	19	thereby	thereby	RB
cord-260476-whfyczcj	12	20	restricting	restrict	VBG
cord-260476-whfyczcj	12	21	the	the	DT
cord-260476-whfyczcj	12	22	viral	viral	JJ
cord-260476-whfyczcj	12	23	infection	infection	NN
cord-260476-whfyczcj	12	24	.	.	.
cord-260476-whfyczcj	13	1	On	on	IN
cord-260476-whfyczcj	13	2	the	the	DT
cord-260476-whfyczcj	13	3	other	other	JJ
cord-260476-whfyczcj	13	4	hand	hand	NN
cord-260476-whfyczcj	13	5	,	,	,
cord-260476-whfyczcj	13	6	it	-PRON-	PRP
cord-260476-whfyczcj	13	7	can	can	MD
cord-260476-whfyczcj	13	8	also	also	RB
cord-260476-whfyczcj	13	9	be	be	VB
cord-260476-whfyczcj	13	10	subverted	subvert	VBN
cord-260476-whfyczcj	13	11	by	by	IN
cord-260476-whfyczcj	13	12	the	the	DT
cord-260476-whfyczcj	13	13	virus	virus	NN
cord-260476-whfyczcj	13	14	to	to	IN
cord-260476-whfyczcj	13	15	its	-PRON-	PRP$
cord-260476-whfyczcj	13	16	own	own	JJ
cord-260476-whfyczcj	13	17	advantage	advantage	NN
cord-260476-whfyczcj	13	18	,	,	,
cord-260476-whfyczcj	13	19	notably	notably	RB
cord-260476-whfyczcj	13	20	to	to	TO
cord-260476-whfyczcj	13	21	induce	induce	VB
cord-260476-whfyczcj	13	22	degradation	degradation	NN
cord-260476-whfyczcj	13	23	of	of	IN
cord-260476-whfyczcj	13	24	cellular	cellular	JJ
cord-260476-whfyczcj	13	25	restriction	restriction	NN
cord-260476-whfyczcj	13	26	factors	factor	NNS
cord-260476-whfyczcj	13	27	.	.	.
cord-260476-whfyczcj	14	1	This	this	DT
cord-260476-whfyczcj	14	2	makes	make	VBZ
cord-260476-whfyczcj	14	3	the	the	DT
cord-260476-whfyczcj	14	4	UPS	UPS	NNP
cord-260476-whfyczcj	14	5	a	a	DT
cord-260476-whfyczcj	14	6	central	central	JJ
cord-260476-whfyczcj	14	7	player	player	NN
cord-260476-whfyczcj	14	8	in	in	IN
cord-260476-whfyczcj	14	9	viral	viral	JJ
cord-260476-whfyczcj	14	10	restriction	restriction	NN
cord-260476-whfyczcj	14	11	and	and	CC
cord-260476-whfyczcj	14	12	counter	counter	NN
cord-260476-whfyczcj	14	13	-	-	NN
cord-260476-whfyczcj	14	14	restriction	restriction	NN
cord-260476-whfyczcj	14	15	.	.	.
cord-260476-whfyczcj	15	1	In	in	IN
cord-260476-whfyczcj	15	2	this	this	DT
cord-260476-whfyczcj	15	3	respect	respect	NN
cord-260476-whfyczcj	15	4	,	,	,
cord-260476-whfyczcj	15	5	the	the	DT
cord-260476-whfyczcj	15	6	human	human	JJ
cord-260476-whfyczcj	15	7	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	15	8	viruses	virus	NNS
cord-260476-whfyczcj	15	9	(	(	-LRB-
cord-260476-whfyczcj	15	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	15	11	and	and	CC
cord-260476-whfyczcj	15	12	2	2	LS
cord-260476-whfyczcj	15	13	)	)	-RRB-
cord-260476-whfyczcj	15	14	represent	represent	VBP
cord-260476-whfyczcj	15	15	excellent	excellent	JJ
cord-260476-whfyczcj	15	16	examples	example	NNS
cord-260476-whfyczcj	15	17	.	.	.
cord-260476-whfyczcj	16	1	Indeed	indeed	RB
cord-260476-whfyczcj	16	2	,	,	,
cord-260476-whfyczcj	16	3	many	many	JJ
cord-260476-whfyczcj	16	4	steps	step	NNS
cord-260476-whfyczcj	16	5	of	of	IN
cord-260476-whfyczcj	16	6	the	the	DT
cord-260476-whfyczcj	16	7	HIV	HIV	NNP
cord-260476-whfyczcj	16	8	life	life	NN
cord-260476-whfyczcj	16	9	cycle	cycle	NN
cord-260476-whfyczcj	16	10	are	be	VBP
cord-260476-whfyczcj	16	11	restricted	restrict	VBN
cord-260476-whfyczcj	16	12	by	by	IN
cord-260476-whfyczcj	16	13	cellular	cellular	JJ
cord-260476-whfyczcj	16	14	proteins	protein	NNS
cord-260476-whfyczcj	16	15	,	,	,
cord-260476-whfyczcj	16	16	some	some	DT
cord-260476-whfyczcj	16	17	of	of	IN
cord-260476-whfyczcj	16	18	which	which	WDT
cord-260476-whfyczcj	16	19	are	be	VBP
cord-260476-whfyczcj	16	20	themselves	-PRON-	PRP
cord-260476-whfyczcj	16	21	components	component	NNS
cord-260476-whfyczcj	16	22	of	of	IN
cord-260476-whfyczcj	16	23	the	the	DT
cord-260476-whfyczcj	16	24	UPS	UPS	NNPS
cord-260476-whfyczcj	16	25	.	.	.
cord-260476-whfyczcj	17	1	However	however	RB
cord-260476-whfyczcj	17	2	,	,	,
cord-260476-whfyczcj	17	3	HIV	HIV	NNP
cord-260476-whfyczcj	17	4	itself	-PRON-	PRP
cord-260476-whfyczcj	17	5	hijacks	hijack	VBZ
cord-260476-whfyczcj	17	6	the	the	DT
cord-260476-whfyczcj	17	7	UPS	UPS	NNP
cord-260476-whfyczcj	17	8	to	to	TO
cord-260476-whfyczcj	17	9	mediate	mediate	VB
cord-260476-whfyczcj	17	10	defense	defense	NN
cord-260476-whfyczcj	17	11	against	against	IN
cord-260476-whfyczcj	17	12	several	several	JJ
cord-260476-whfyczcj	17	13	cellular	cellular	JJ
cord-260476-whfyczcj	17	14	restriction	restriction	NN
cord-260476-whfyczcj	17	15	factors	factor	NNS
cord-260476-whfyczcj	17	16	.	.	.
cord-260476-whfyczcj	18	1	For	for	IN
cord-260476-whfyczcj	18	2	example	example	NN
cord-260476-whfyczcj	18	3	,	,	,
cord-260476-whfyczcj	18	4	the	the	DT
cord-260476-whfyczcj	18	5	HIV	HIV	NNP
cord-260476-whfyczcj	18	6	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	18	7	proteins	protein	NNS
cord-260476-whfyczcj	18	8	Vif	Vif	NNP
cord-260476-whfyczcj	18	9	,	,	,
cord-260476-whfyczcj	18	10	Vpx	Vpx	NNP
cord-260476-whfyczcj	18	11	and	and	CC
cord-260476-whfyczcj	18	12	Vpu	Vpu	NNP
cord-260476-whfyczcj	18	13	counteract	counteract	VBP
cord-260476-whfyczcj	18	14	specific	specific	JJ
cord-260476-whfyczcj	18	15	restriction	restriction	NN
cord-260476-whfyczcj	18	16	factors	factor	NNS
cord-260476-whfyczcj	18	17	by	by	IN
cord-260476-whfyczcj	18	18	the	the	DT
cord-260476-whfyczcj	18	19	recruitment	recruitment	NN
cord-260476-whfyczcj	18	20	of	of	IN
cord-260476-whfyczcj	18	21	cellular	cellular	JJ
cord-260476-whfyczcj	18	22	UPS	UPS	NNP
cord-260476-whfyczcj	18	23	components	component	NNS
cord-260476-whfyczcj	18	24	.	.	.
cord-260476-whfyczcj	19	1	In	in	IN
cord-260476-whfyczcj	19	2	this	this	DT
cord-260476-whfyczcj	19	3	review	review	NN
cord-260476-whfyczcj	19	4	,	,	,
cord-260476-whfyczcj	19	5	we	-PRON-	PRP
cord-260476-whfyczcj	19	6	describe	describe	VBP
cord-260476-whfyczcj	19	7	the	the	DT
cord-260476-whfyczcj	19	8	interplay	interplay	NN
cord-260476-whfyczcj	19	9	between	between	IN
cord-260476-whfyczcj	19	10	HIV	HIV	NNP
cord-260476-whfyczcj	19	11	and	and	CC
cord-260476-whfyczcj	19	12	the	the	DT
cord-260476-whfyczcj	19	13	UPS	up	NNS
cord-260476-whfyczcj	19	14	to	to	TO
cord-260476-whfyczcj	19	15	illustrate	illustrate	VB
cord-260476-whfyczcj	19	16	its	-PRON-	PRP$
cord-260476-whfyczcj	19	17	role	role	NN
cord-260476-whfyczcj	19	18	in	in	IN
cord-260476-whfyczcj	19	19	the	the	DT
cord-260476-whfyczcj	19	20	restriction	restriction	NN
cord-260476-whfyczcj	19	21	of	of	IN
cord-260476-whfyczcj	19	22	viral	viral	JJ
cord-260476-whfyczcj	19	23	infections	infection	NNS
cord-260476-whfyczcj	19	24	and	and	CC
cord-260476-whfyczcj	19	25	its	-PRON-	PRP$
cord-260476-whfyczcj	19	26	hijacking	hijacking	NN
cord-260476-whfyczcj	19	27	by	by	IN
cord-260476-whfyczcj	19	28	viral	viral	JJ
cord-260476-whfyczcj	19	29	proteins	protein	NNS
cord-260476-whfyczcj	19	30	for	for	IN
cord-260476-whfyczcj	19	31	counter	counter	NN
cord-260476-whfyczcj	19	32	-	-	NN
cord-260476-whfyczcj	19	33	restriction	restriction	NN
cord-260476-whfyczcj	19	34	.	.	.
cord-260476-whfyczcj	20	1	The	the	DT
cord-260476-whfyczcj	20	2	human	human	JJ
cord-260476-whfyczcj	20	3	cell	cell	NN
cord-260476-whfyczcj	20	4	is	be	VBZ
cord-260476-whfyczcj	20	5	in	in	IN
cord-260476-whfyczcj	20	6	a	a	DT
cord-260476-whfyczcj	20	7	continuous	continuous	JJ
cord-260476-whfyczcj	20	8	arms	arm	NNS
cord-260476-whfyczcj	20	9	race	race	NN
cord-260476-whfyczcj	20	10	with	with	IN
cord-260476-whfyczcj	20	11	various	various	JJ
cord-260476-whfyczcj	20	12	viruses	virus	NNS
cord-260476-whfyczcj	20	13	.	.	.
cord-260476-whfyczcj	21	1	This	this	DT
cord-260476-whfyczcj	21	2	has	have	VBZ
cord-260476-whfyczcj	21	3	led	lead	VBN
cord-260476-whfyczcj	21	4	to	to	IN
cord-260476-whfyczcj	21	5	the	the	DT
cord-260476-whfyczcj	21	6	coevolution	coevolution	NN
cord-260476-whfyczcj	21	7	of	of	IN
cord-260476-whfyczcj	21	8	cellular	cellular	JJ
cord-260476-whfyczcj	21	9	restriction	restriction	NN
cord-260476-whfyczcj	21	10	factors	factor	NNS
cord-260476-whfyczcj	21	11	on	on	IN
cord-260476-whfyczcj	21	12	the	the	DT
cord-260476-whfyczcj	21	13	one	one	CD
cord-260476-whfyczcj	21	14	hand	hand	NN
cord-260476-whfyczcj	21	15	and	and	CC
cord-260476-whfyczcj	21	16	viral	viral	JJ
cord-260476-whfyczcj	21	17	proteins	protein	NNS
cord-260476-whfyczcj	21	18	for	for	IN
cord-260476-whfyczcj	21	19	counter	counter	NN
cord-260476-whfyczcj	21	20	-	-	NN
cord-260476-whfyczcj	21	21	defense	defense	NN
cord-260476-whfyczcj	21	22	on	on	IN
cord-260476-whfyczcj	21	23	the	the	DT
cord-260476-whfyczcj	21	24	other	other	JJ
cord-260476-whfyczcj	21	25	hand	hand	NN
cord-260476-whfyczcj	21	26	.	.	.
cord-260476-whfyczcj	22	1	Restriction	restriction	NN
cord-260476-whfyczcj	22	2	factors	factor	NNS
cord-260476-whfyczcj	22	3	are	be	VBP
cord-260476-whfyczcj	22	4	generally	generally	RB
cord-260476-whfyczcj	22	5	induced	induce	VBN
cord-260476-whfyczcj	22	6	as	as	IN
cord-260476-whfyczcj	22	7	a	a	DT
cord-260476-whfyczcj	22	8	result	result	NN
cord-260476-whfyczcj	22	9	of	of	IN
cord-260476-whfyczcj	22	10	an	an	DT
cord-260476-whfyczcj	22	11	interferon	interferon	NN
cord-260476-whfyczcj	22	12	response	response	NN
cord-260476-whfyczcj	22	13	-	-	:
cord-260476-whfyczcj	22	14	they	-PRON-	PRP
cord-260476-whfyczcj	22	15	use	use	VBP
cord-260476-whfyczcj	22	16	unique	unique	JJ
cord-260476-whfyczcj	22	17	mechanisms	mechanism	NNS
cord-260476-whfyczcj	22	18	to	to	TO
cord-260476-whfyczcj	22	19	impair	impair	VB
cord-260476-whfyczcj	22	20	specific	specific	JJ
cord-260476-whfyczcj	22	21	steps	step	NNS
cord-260476-whfyczcj	22	22	of	of	IN
cord-260476-whfyczcj	22	23	the	the	DT
cord-260476-whfyczcj	22	24	replication	replication	NN
cord-260476-whfyczcj	22	25	cycle	cycle	NN
cord-260476-whfyczcj	22	26	and	and	CC
cord-260476-whfyczcj	22	27	they	-PRON-	PRP
cord-260476-whfyczcj	22	28	exhibit	exhibit	VBP
cord-260476-whfyczcj	22	29	a	a	DT
cord-260476-whfyczcj	22	30	dominant	dominant	JJ
cord-260476-whfyczcj	22	31	and	and	CC
cord-260476-whfyczcj	22	32	autonomous	autonomous	JJ
cord-260476-whfyczcj	22	33	effect	effect	NN
cord-260476-whfyczcj	22	34	.	.	.
cord-260476-whfyczcj	23	1	In	in	IN
cord-260476-whfyczcj	23	2	this	this	DT
cord-260476-whfyczcj	23	3	continuous	continuous	JJ
cord-260476-whfyczcj	23	4	fight	fight	NN
cord-260476-whfyczcj	23	5	,	,	,
cord-260476-whfyczcj	23	6	the	the	DT
cord-260476-whfyczcj	23	7	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	23	8	-	-	HYPH
cord-260476-whfyczcj	23	9	proteasome	proteasome	VBN
cord-260476-whfyczcj	23	10	system	system	NN
cord-260476-whfyczcj	23	11	(	(	-LRB-
cord-260476-whfyczcj	23	12	UPS	UPS	NNP
cord-260476-whfyczcj	23	13	)	)	-RRB-
cord-260476-whfyczcj	23	14	plays	play	VBZ
cord-260476-whfyczcj	23	15	a	a	DT
cord-260476-whfyczcj	23	16	central	central	JJ
cord-260476-whfyczcj	23	17	role	role	NN
cord-260476-whfyczcj	23	18	on	on	IN
cord-260476-whfyczcj	23	19	the	the	DT
cord-260476-whfyczcj	23	20	cellular	cellular	NN
cord-260476-whfyczcj	23	21	as	as	RB
cord-260476-whfyczcj	23	22	well	well	RB
cord-260476-whfyczcj	23	23	as	as	IN
cord-260476-whfyczcj	23	24	on	on	IN
cord-260476-whfyczcj	23	25	the	the	DT
cord-260476-whfyczcj	23	26	viral	viral	JJ
cord-260476-whfyczcj	23	27	side	side	NN
cord-260476-whfyczcj	23	28	.	.	.
cord-260476-whfyczcj	24	1	The	the	DT
cord-260476-whfyczcj	24	2	cell	cell	NN
cord-260476-whfyczcj	24	3	expresses	express	VBZ
cord-260476-whfyczcj	24	4	restriction	restriction	NN
cord-260476-whfyczcj	24	5	factors	factor	NNS
cord-260476-whfyczcj	24	6	,	,	,
cord-260476-whfyczcj	24	7	some	some	DT
cord-260476-whfyczcj	24	8	of	of	IN
cord-260476-whfyczcj	24	9	which	which	WDT
cord-260476-whfyczcj	24	10	are	be	VBP
cord-260476-whfyczcj	24	11	themselves	-PRON-	PRP
cord-260476-whfyczcj	24	12	components	component	NNS
cord-260476-whfyczcj	24	13	of	of	IN
cord-260476-whfyczcj	24	14	the	the	DT
cord-260476-whfyczcj	24	15	UPS	UPS	NNPS
cord-260476-whfyczcj	24	16	,	,	,
cord-260476-whfyczcj	24	17	targeting	target	VBG
cord-260476-whfyczcj	24	18	viral	viral	JJ
cord-260476-whfyczcj	24	19	proteins	protein	NNS
cord-260476-whfyczcj	24	20	for	for	IN
cord-260476-whfyczcj	24	21	degradation	degradation	NN
cord-260476-whfyczcj	24	22	and	and	CC
cord-260476-whfyczcj	24	23	thereby	thereby	RB
cord-260476-whfyczcj	24	24	inhibiting	inhibit	VBG
cord-260476-whfyczcj	24	25	some	some	DT
cord-260476-whfyczcj	24	26	crucial	crucial	JJ
cord-260476-whfyczcj	24	27	steps	step	NNS
cord-260476-whfyczcj	24	28	of	of	IN
cord-260476-whfyczcj	24	29	the	the	DT
cord-260476-whfyczcj	24	30	viral	viral	JJ
cord-260476-whfyczcj	24	31	life	life	NN
cord-260476-whfyczcj	24	32	cycle	cycle	NN
cord-260476-whfyczcj	24	33	.	.	.
cord-260476-whfyczcj	25	1	However	however	RB
cord-260476-whfyczcj	25	2	,	,	,
cord-260476-whfyczcj	25	3	viruses	virus	NNS
cord-260476-whfyczcj	25	4	have	have	VBP
cord-260476-whfyczcj	25	5	evolved	evolve	VBN
cord-260476-whfyczcj	25	6	to	to	TO
cord-260476-whfyczcj	25	7	use	use	VB
cord-260476-whfyczcj	25	8	the	the	DT
cord-260476-whfyczcj	25	9	UPS	up	NNS
cord-260476-whfyczcj	25	10	to	to	IN
cord-260476-whfyczcj	25	11	their	-PRON-	PRP$
cord-260476-whfyczcj	25	12	own	own	JJ
cord-260476-whfyczcj	25	13	benefits	benefit	NNS
cord-260476-whfyczcj	25	14	,	,	,
cord-260476-whfyczcj	25	15	subverting	subvert	VBG
cord-260476-whfyczcj	25	16	components	component	NNS
cord-260476-whfyczcj	25	17	of	of	IN
cord-260476-whfyczcj	25	18	the	the	DT
cord-260476-whfyczcj	25	19	UPS	up	NNS
cord-260476-whfyczcj	25	20	to	to	TO
cord-260476-whfyczcj	25	21	degrade	degrade	VB
cord-260476-whfyczcj	25	22	restriction	restriction	NN
cord-260476-whfyczcj	25	23	factors	factor	NNS
cord-260476-whfyczcj	25	24	,	,	,
cord-260476-whfyczcj	25	25	thereby	thereby	RB
cord-260476-whfyczcj	25	26	protecting	protect	VBG
cord-260476-whfyczcj	25	27	themselves	-PRON-	PRP
cord-260476-whfyczcj	25	28	from	from	IN
cord-260476-whfyczcj	25	29	the	the	DT
cord-260476-whfyczcj	25	30	cellular	cellular	JJ
cord-260476-whfyczcj	25	31	defense	defense	NN
cord-260476-whfyczcj	25	32	machinery	machinery	NN
cord-260476-whfyczcj	25	33	to	to	TO
cord-260476-whfyczcj	25	34	allow	allow	VB
cord-260476-whfyczcj	25	35	their	-PRON-	PRP$
cord-260476-whfyczcj	25	36	dissemination	dissemination	NN
cord-260476-whfyczcj	25	37	.	.	.
cord-260476-whfyczcj	26	1	In	in	IN
cord-260476-whfyczcj	26	2	this	this	DT
cord-260476-whfyczcj	26	3	review	review	NN
cord-260476-whfyczcj	26	4	,	,	,
cord-260476-whfyczcj	26	5	we	-PRON-	PRP
cord-260476-whfyczcj	26	6	will	will	MD
cord-260476-whfyczcj	26	7	describe	describe	VB
cord-260476-whfyczcj	26	8	the	the	DT
cord-260476-whfyczcj	26	9	mechanisms	mechanism	NNS
cord-260476-whfyczcj	26	10	by	by	IN
cord-260476-whfyczcj	26	11	which	which	WDT
cord-260476-whfyczcj	26	12	the	the	DT
cord-260476-whfyczcj	26	13	human	human	JJ
cord-260476-whfyczcj	26	14	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	26	15	viruses	virus	NNS
cord-260476-whfyczcj	26	16	(	(	-LRB-
cord-260476-whfyczcj	26	17	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	26	18	and	and	CC
cord-260476-whfyczcj	26	19	2	2	LS
cord-260476-whfyczcj	26	20	)	)	-RRB-
cord-260476-whfyczcj	26	21	use	use	VBP
cord-260476-whfyczcj	26	22	and	and	CC
cord-260476-whfyczcj	26	23	subvert	subvert	VB
cord-260476-whfyczcj	26	24	the	the	DT
cord-260476-whfyczcj	26	25	UPS	up	NNS
cord-260476-whfyczcj	26	26	in	in	IN
cord-260476-whfyczcj	26	27	the	the	DT
cord-260476-whfyczcj	26	28	continuous	continuous	JJ
cord-260476-whfyczcj	26	29	battle	battle	NN
cord-260476-whfyczcj	26	30	between	between	IN
cord-260476-whfyczcj	26	31	cellular	cellular	JJ
cord-260476-whfyczcj	26	32	defense	defense	NN
cord-260476-whfyczcj	26	33	and	and	CC
cord-260476-whfyczcj	26	34	viral	viral	JJ
cord-260476-whfyczcj	26	35	counter	counter	NN
cord-260476-whfyczcj	26	36	-	-	NN
cord-260476-whfyczcj	26	37	defense	defense	NN
cord-260476-whfyczcj	26	38	.	.	.
cord-260476-whfyczcj	27	1	The	the	DT
cord-260476-whfyczcj	27	2	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	27	3	-	-	HYPH
cord-260476-whfyczcj	27	4	proteasome	proteasome	VBN
cord-260476-whfyczcj	27	5	system	system	NN
cord-260476-whfyczcj	27	6	(	(	-LRB-
cord-260476-whfyczcj	27	7	UPS	UPS	NNP
cord-260476-whfyczcj	27	8	)	)	-RRB-
cord-260476-whfyczcj	27	9	is	be	VBZ
cord-260476-whfyczcj	27	10	an	an	DT
cord-260476-whfyczcj	27	11	important	important	JJ
cord-260476-whfyczcj	27	12	pathway	pathway	NN
cord-260476-whfyczcj	27	13	in	in	IN
cord-260476-whfyczcj	27	14	the	the	DT
cord-260476-whfyczcj	27	15	cell	cell	NN
cord-260476-whfyczcj	27	16	,	,	,
cord-260476-whfyczcj	27	17	ensuring	ensure	VBG
cord-260476-whfyczcj	27	18	regulation	regulation	NN
cord-260476-whfyczcj	27	19	of	of	IN
cord-260476-whfyczcj	27	20	the	the	DT
cord-260476-whfyczcj	27	21	protein	protein	NN
cord-260476-whfyczcj	27	22	pool	pool	NN
cord-260476-whfyczcj	27	23	in	in	IN
cord-260476-whfyczcj	27	24	the	the	DT
cord-260476-whfyczcj	27	25	cytoplasm	cytoplasm	NN
cord-260476-whfyczcj	27	26	as	as	RB
cord-260476-whfyczcj	27	27	well	well	RB
cord-260476-whfyczcj	27	28	as	as	IN
cord-260476-whfyczcj	27	29	in	in	IN
cord-260476-whfyczcj	27	30	the	the	DT
cord-260476-whfyczcj	27	31	nucleus	nucleus	NN
cord-260476-whfyczcj	27	32	.	.	.
cord-260476-whfyczcj	28	1	The	the	DT
cord-260476-whfyczcj	28	2	UPS	UPS	NNP
cord-260476-whfyczcj	28	3	is	be	VBZ
cord-260476-whfyczcj	28	4	constituted	constitute	VBN
cord-260476-whfyczcj	28	5	by	by	IN
cord-260476-whfyczcj	28	6	three	three	CD
cord-260476-whfyczcj	28	7	main	main	JJ
cord-260476-whfyczcj	28	8	components	component	NNS
cord-260476-whfyczcj	28	9	:	:	:
cord-260476-whfyczcj	28	10	the	the	DT
cord-260476-whfyczcj	28	11	proteasome	proteasome	NN
cord-260476-whfyczcj	28	12	holoenzymes	holoenzymes	NN
cord-260476-whfyczcj	28	13	,	,	,
cord-260476-whfyczcj	28	14	several	several	JJ
cord-260476-whfyczcj	28	15	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	28	16	ligases	ligase	NNS
cord-260476-whfyczcj	28	17	and	and	CC
cord-260476-whfyczcj	28	18	a	a	DT
cord-260476-whfyczcj	28	19	large	large	JJ
cord-260476-whfyczcj	28	20	variety	variety	NN
cord-260476-whfyczcj	28	21	of	of	IN
cord-260476-whfyczcj	28	22	deubiquitinating	deubiquitinate	VBG
cord-260476-whfyczcj	28	23	enzymes	enzyme	NNS
cord-260476-whfyczcj	28	24	(	(	-LRB-
cord-260476-whfyczcj	28	25	DUBs	dub	NNS
cord-260476-whfyczcj	28	26	)	)	-RRB-
cord-260476-whfyczcj	28	27	[	[	-LRB-
cord-260476-whfyczcj	28	28	1	1	CD
cord-260476-whfyczcj	28	29	]	]	-RRB-
cord-260476-whfyczcj	28	30	.	.	.
cord-260476-whfyczcj	29	1	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	29	2	is	be	VBZ
cord-260476-whfyczcj	29	3	a	a	DT
cord-260476-whfyczcj	29	4	ubiquitously	ubiquitously	RB
cord-260476-whfyczcj	29	5	expressed	express	VBN
cord-260476-whfyczcj	29	6	and	and	CC
cord-260476-whfyczcj	29	7	well	well	RB
cord-260476-whfyczcj	29	8	-	-	HYPH
cord-260476-whfyczcj	29	9	conserved	conserve	VBN
cord-260476-whfyczcj	29	10	The	the	DT
cord-260476-whfyczcj	29	11	UPS	UPS	NNP
cord-260476-whfyczcj	29	12	plays	play	VBZ
cord-260476-whfyczcj	29	13	a	a	DT
cord-260476-whfyczcj	29	14	central	central	JJ
cord-260476-whfyczcj	29	15	role	role	NN
cord-260476-whfyczcj	29	16	in	in	IN
cord-260476-whfyczcj	29	17	many	many	JJ
cord-260476-whfyczcj	29	18	viral	viral	JJ
cord-260476-whfyczcj	29	19	infections	infection	NNS
cord-260476-whfyczcj	29	20	(	(	-LRB-
cord-260476-whfyczcj	29	21	reviewed	review	VBN
cord-260476-whfyczcj	29	22	in	in	IN
cord-260476-whfyczcj	29	23	[	[	-LRB-
cord-260476-whfyczcj	29	24	18	18	CD
cord-260476-whfyczcj	29	25	]	]	-RRB-
cord-260476-whfyczcj	30	1	[	[	-LRB-
cord-260476-whfyczcj	30	2	19	19	CD
cord-260476-whfyczcj	30	3	]	]	-RRB-
cord-260476-whfyczcj	30	4	[	[	-LRB-
cord-260476-whfyczcj	30	5	20	20	CD
cord-260476-whfyczcj	30	6	]	]	-RRB-
cord-260476-whfyczcj	30	7	)	)	-RRB-
cord-260476-whfyczcj	30	8	,	,	,
cord-260476-whfyczcj	30	9	with	with	IN
cord-260476-whfyczcj	30	10	five	five	CD
cord-260476-whfyczcj	30	11	main	main	JJ
cord-260476-whfyczcj	30	12	modes	mode	NNS
cord-260476-whfyczcj	30	13	of	of	IN
cord-260476-whfyczcj	30	14	action	action	NN
cord-260476-whfyczcj	30	15	on	on	IN
cord-260476-whfyczcj	30	16	the	the	DT
cord-260476-whfyczcj	30	17	viral	viral	JJ
cord-260476-whfyczcj	30	18	life	life	NN
cord-260476-whfyczcj	30	19	cycle	cycle	NN
cord-260476-whfyczcj	30	20	:	:	:
cord-260476-whfyczcj	30	21	(	(	-LRB-
cord-260476-whfyczcj	30	22	1	1	LS
cord-260476-whfyczcj	30	23	)	)	-RRB-
cord-260476-whfyczcj	31	1	Some	some	DT
cord-260476-whfyczcj	31	2	cellular	cellular	JJ
cord-260476-whfyczcj	31	3	E3	e3	NN
cord-260476-whfyczcj	31	4	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	31	5	ligases	ligase	NNS
cord-260476-whfyczcj	31	6	recognize	recognize	VBP
cord-260476-whfyczcj	31	7	viral	viral	JJ
cord-260476-whfyczcj	31	8	proteins	protein	NNS
cord-260476-whfyczcj	31	9	and	and	CC
cord-260476-whfyczcj	31	10	induce	induce	VB
cord-260476-whfyczcj	31	11	their	-PRON-	PRP$
cord-260476-whfyczcj	31	12	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	31	13	,	,	,
cord-260476-whfyczcj	31	14	which	which	WDT
cord-260476-whfyczcj	31	15	can	can	MD
cord-260476-whfyczcj	31	16	have	have	VB
cord-260476-whfyczcj	31	17	a	a	DT
cord-260476-whfyczcj	31	18	positive	positive	JJ
cord-260476-whfyczcj	31	19	effect	effect	NN
cord-260476-whfyczcj	31	20	on	on	IN
cord-260476-whfyczcj	31	21	viral	viral	JJ
cord-260476-whfyczcj	31	22	replication	replication	NN
cord-260476-whfyczcj	31	23	.	.	.
cord-260476-whfyczcj	32	1	For	for	IN
cord-260476-whfyczcj	32	2	instance	instance	NN
cord-260476-whfyczcj	32	3	,	,	,
cord-260476-whfyczcj	32	4	ubiquitination	ubiquitination	IN
cord-260476-whfyczcj	32	5	of	of	IN
cord-260476-whfyczcj	32	6	the	the	DT
cord-260476-whfyczcj	32	7	p6	p6	NN
cord-260476-whfyczcj	32	8	domain	domain	NN
cord-260476-whfyczcj	32	9	of	of	IN
cord-260476-whfyczcj	32	10	the	the	DT
cord-260476-whfyczcj	32	11	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	32	12	Gag	Gag	NNP
cord-260476-whfyczcj	32	13	polyprotein	polyprotein	NN
cord-260476-whfyczcj	32	14	is	be	VBZ
cord-260476-whfyczcj	32	15	important	important	JJ
cord-260476-whfyczcj	32	16	for	for	IN
cord-260476-whfyczcj	32	17	the	the	DT
cord-260476-whfyczcj	32	18	interaction	interaction	NN
cord-260476-whfyczcj	32	19	of	of	IN
cord-260476-whfyczcj	32	20	p6	p6	NN
cord-260476-whfyczcj	32	21	with	with	IN
cord-260476-whfyczcj	32	22	the	the	DT
cord-260476-whfyczcj	32	23	ESCRT	ESCRT	NNP
cord-260476-whfyczcj	32	24	machinery	machinery	NN
cord-260476-whfyczcj	32	25	.	.	.
cord-260476-whfyczcj	33	1	However	however	RB
cord-260476-whfyczcj	33	2	,	,	,
cord-260476-whfyczcj	33	3	the	the	DT
cord-260476-whfyczcj	33	4	mono	mono	NN
cord-260476-whfyczcj	33	5	-	-	HYPH
cord-260476-whfyczcj	33	6	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	33	7	of	of	IN
cord-260476-whfyczcj	33	8	lysine	lysine	NN
cord-260476-whfyczcj	33	9	residues	residue	NNS
cord-260476-whfyczcj	33	10	within	within	IN
cord-260476-whfyczcj	33	11	the	the	DT
cord-260476-whfyczcj	33	12	p6	p6	NN
cord-260476-whfyczcj	33	13	domain	domain	NN
cord-260476-whfyczcj	33	14	(	(	-LRB-
cord-260476-whfyczcj	33	15	K27	K27	NNP
cord-260476-whfyczcj	33	16	and	and	CC
cord-260476-whfyczcj	33	17	K33	K33	NNP
cord-260476-whfyczcj	33	18	)	)	-RRB-
cord-260476-whfyczcj	33	19	does	do	VBZ
cord-260476-whfyczcj	33	20	not	not	RB
cord-260476-whfyczcj	33	21	seem	seem	VB
cord-260476-whfyczcj	33	22	to	to	TO
cord-260476-whfyczcj	33	23	be	be	VB
cord-260476-whfyczcj	33	24	sufficient	sufficient	JJ
cord-260476-whfyczcj	33	25	to	to	TO
cord-260476-whfyczcj	33	26	facilitate	facilitate	VB
cord-260476-whfyczcj	33	27	budding	bud	VBG
cord-260476-whfyczcj	33	28	of	of	IN
cord-260476-whfyczcj	33	29	new	new	JJ
cord-260476-whfyczcj	33	30	virions	virion	NNS
cord-260476-whfyczcj	33	31	,	,	,
cord-260476-whfyczcj	33	32	the	the	DT
cord-260476-whfyczcj	33	33	latter	latter	JJ
cord-260476-whfyczcj	33	34	being	be	VBG
cord-260476-whfyczcj	33	35	also	also	RB
cord-260476-whfyczcj	33	36	dependent	dependent	JJ
cord-260476-whfyczcj	33	37	on	on	IN
cord-260476-whfyczcj	33	38	the	the	DT
cord-260476-whfyczcj	33	39	cumulative	cumulative	JJ
cord-260476-whfyczcj	33	40	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	33	41	of	of	IN
cord-260476-whfyczcj	33	42	NC	NC	NNP
cord-260476-whfyczcj	33	43	-	-	HYPH
cord-260476-whfyczcj	33	44	p2	p2	NNP
cord-260476-whfyczcj	33	45	(	(	-LRB-
cord-260476-whfyczcj	33	46	NucleoCapsid	NucleoCapsid	NNP
cord-260476-whfyczcj	33	47	-	-	HYPH
cord-260476-whfyczcj	33	48	peptide	peptide	NN
cord-260476-whfyczcj	33	49	2	2	CD
cord-260476-whfyczcj	33	50	)	)	-RRB-
cord-260476-whfyczcj	33	51	domain	domain	NN
cord-260476-whfyczcj	33	52	[	[	-LRB-
cord-260476-whfyczcj	33	53	21	21	CD
cord-260476-whfyczcj	33	54	]	]	-RRB-
cord-260476-whfyczcj	33	55	[	[	-LRB-
cord-260476-whfyczcj	33	56	22	22	CD
cord-260476-whfyczcj	33	57	]	]	-RRB-
cord-260476-whfyczcj	33	58	[	[	-LRB-
cord-260476-whfyczcj	33	59	23	23	CD
cord-260476-whfyczcj	33	60	]	]	-RRB-
cord-260476-whfyczcj	33	61	[	[	-LRB-
cord-260476-whfyczcj	33	62	24	24	CD
cord-260476-whfyczcj	33	63	]	]	-RRB-
cord-260476-whfyczcj	33	64	.	.	.
cord-260476-whfyczcj	34	1	Ubiquitination	Ubiquitination	NNP
cord-260476-whfyczcj	34	2	of	of	IN
cord-260476-whfyczcj	34	3	the	the	DT
cord-260476-whfyczcj	34	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	34	5	accessory	accessory	NN
cord-260476-whfyczcj	34	6	protein	protein	NN
cord-260476-whfyczcj	34	7	Tat	Tat	NNP
cord-260476-whfyczcj	34	8	by	by	IN
cord-260476-whfyczcj	34	9	cellular	cellular	JJ
cord-260476-whfyczcj	34	10	E3	e3	NN
cord-260476-whfyczcj	34	11	ligases	ligase	NNS
cord-260476-whfyczcj	34	12	stimulates	stimulate	VBZ
cord-260476-whfyczcj	34	13	transcription	transcription	NN
cord-260476-whfyczcj	34	14	of	of	IN
cord-260476-whfyczcj	34	15	viral	viral	JJ
cord-260476-whfyczcj	34	16	RNA	RNA	NNP
cord-260476-whfyczcj	34	17	[	[	-LRB-
cord-260476-whfyczcj	34	18	25	25	CD
cord-260476-whfyczcj	34	19	,	,	,
cord-260476-whfyczcj	34	20	26	26	CD
cord-260476-whfyczcj	34	21	]	]	-RRB-
cord-260476-whfyczcj	34	22	.	.	.
cord-260476-whfyczcj	35	1	(	(	-LRB-
cord-260476-whfyczcj	35	2	2	2	LS
cord-260476-whfyczcj	35	3	)	)	-RRB-
cord-260476-whfyczcj	35	4	Ubiquitination	Ubiquitination	NNP
cord-260476-whfyczcj	35	5	of	of	IN
cord-260476-whfyczcj	35	6	viral	viral	JJ
cord-260476-whfyczcj	35	7	proteins	protein	NNS
cord-260476-whfyczcj	35	8	can	can	MD
cord-260476-whfyczcj	35	9	also	also	RB
cord-260476-whfyczcj	35	10	induce	induce	VB
cord-260476-whfyczcj	35	11	their	-PRON-	PRP$
cord-260476-whfyczcj	35	12	degradation	degradation	NN
cord-260476-whfyczcj	35	13	,	,	,
cord-260476-whfyczcj	35	14	thereby	thereby	RB
cord-260476-whfyczcj	35	15	blocking	block	VBG
cord-260476-whfyczcj	35	16	the	the	DT
cord-260476-whfyczcj	35	17	viral	viral	JJ
cord-260476-whfyczcj	35	18	life	life	NN
cord-260476-whfyczcj	35	19	cycle	cycle	NN
cord-260476-whfyczcj	35	20	.	.	.
cord-260476-whfyczcj	36	1	This	this	DT
cord-260476-whfyczcj	36	2	is	be	VBZ
cord-260476-whfyczcj	36	3	a	a	DT
cord-260476-whfyczcj	36	4	strategy	strategy	NN
cord-260476-whfyczcj	36	5	used	use	VBN
cord-260476-whfyczcj	36	6	by	by	IN
cord-260476-whfyczcj	36	7	certain	certain	JJ
cord-260476-whfyczcj	36	8	restriction	restriction	NN
cord-260476-whfyczcj	36	9	factors	factor	NNS
cord-260476-whfyczcj	36	10	.	.	.
cord-260476-whfyczcj	37	1	The	the	DT
cord-260476-whfyczcj	37	2	polymerase	polymerase	NN
cord-260476-whfyczcj	37	3	PB1	pb1	NN
cord-260476-whfyczcj	37	4	(	(	-LRB-
cord-260476-whfyczcj	37	5	Protein	protein	NN
cord-260476-whfyczcj	37	6	Binding	Binding	NNP
cord-260476-whfyczcj	37	7	1	1	CD
cord-260476-whfyczcj	37	8	)	)	-RRB-
cord-260476-whfyczcj	37	9	of	of	IN
cord-260476-whfyczcj	37	10	the	the	DT
cord-260476-whfyczcj	37	11	Influenza	Influenza	NNP
cord-260476-whfyczcj	37	12	A	A	NNP
cord-260476-whfyczcj	37	13	virus	virus	NN
cord-260476-whfyczcj	37	14	(	(	-LRB-
cord-260476-whfyczcj	37	15	IAV	IAV	NNP
cord-260476-whfyczcj	37	16	)	)	-RRB-
cord-260476-whfyczcj	37	17	for	for	IN
cord-260476-whfyczcj	37	18	example	example	NN
cord-260476-whfyczcj	37	19	is	be	VBZ
cord-260476-whfyczcj	37	20	ubiquitinated	ubiquitinate	VBN
cord-260476-whfyczcj	37	21	(	(	-LRB-
cord-260476-whfyczcj	37	22	K48-linked	K48-linked	NNP
cord-260476-whfyczcj	37	23	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	37	24	)	)	-RRB-
cord-260476-whfyczcj	37	25	by	by	IN
cord-260476-whfyczcj	37	26	the	the	DT
cord-260476-whfyczcj	37	27	cellular	cellular	JJ
cord-260476-whfyczcj	37	28	E3	e3	NN
cord-260476-whfyczcj	37	29	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	37	30	ligase	ligase	NN
cord-260476-whfyczcj	38	1	TRIM32	TRIM32	NNP
cord-260476-whfyczcj	39	1	(	(	-LRB-
cord-260476-whfyczcj	39	2	TRIpartite	TRIpartite	NNP
cord-260476-whfyczcj	39	3	Motif	Motif	NNP
cord-260476-whfyczcj	39	4	-	-	HYPH
cord-260476-whfyczcj	39	5	containing	contain	VBG
cord-260476-whfyczcj	39	6	protein	protein	NN
cord-260476-whfyczcj	39	7	32	32	CD
cord-260476-whfyczcj	39	8	)	)	-RRB-
cord-260476-whfyczcj	39	9	,	,	,
cord-260476-whfyczcj	39	10	followed	follow	VBN
cord-260476-whfyczcj	39	11	by	by	IN
cord-260476-whfyczcj	39	12	its	-PRON-	PRP$
cord-260476-whfyczcj	39	13	degradation	degradation	NN
cord-260476-whfyczcj	39	14	by	by	IN
cord-260476-whfyczcj	39	15	the	the	DT
cord-260476-whfyczcj	39	16	proteasome	proteasome	NN
cord-260476-whfyczcj	39	17	[	[	-LRB-
cord-260476-whfyczcj	39	18	27	27	CD
cord-260476-whfyczcj	39	19	]	]	-RRB-
cord-260476-whfyczcj	39	20	.	.	.
cord-260476-whfyczcj	40	1	This	this	DT
cord-260476-whfyczcj	40	2	seems	seem	VBZ
cord-260476-whfyczcj	40	3	to	to	TO
cord-260476-whfyczcj	40	4	be	be	VB
cord-260476-whfyczcj	40	5	a	a	DT
cord-260476-whfyczcj	40	6	general	general	JJ
cord-260476-whfyczcj	40	7	mechanism	mechanism	NN
cord-260476-whfyczcj	40	8	as	as	IN
cord-260476-whfyczcj	40	9	PB1	pb1	NN
cord-260476-whfyczcj	40	10	proteins	protein	NNS
cord-260476-whfyczcj	40	11	derived	derive	VBN
cord-260476-whfyczcj	40	12	from	from	IN
cord-260476-whfyczcj	40	13	various	various	JJ
cord-260476-whfyczcj	40	14	IAV	IAV	NNP
cord-260476-whfyczcj	40	15	serotypes	serotype	NNS
cord-260476-whfyczcj	40	16	(	(	-LRB-
cord-260476-whfyczcj	40	17	H1N1	H1N1	NNP
cord-260476-whfyczcj	40	18	(	(	-LRB-
cord-260476-whfyczcj	40	19	Hemagglutinin	Hemagglutinin	NNP
cord-260476-whfyczcj	40	20	1	1	CD
cord-260476-whfyczcj	40	21	Neuraminidase	Neuraminidase	NNP
cord-260476-whfyczcj	40	22	1	1	CD
cord-260476-whfyczcj	40	23	)	)	-RRB-
cord-260476-whfyczcj	40	24	,	,	,
cord-260476-whfyczcj	40	25	H3N2	H3N2	NNP
cord-260476-whfyczcj	40	26	,	,	,
cord-260476-whfyczcj	40	27	H5N1	H5N1	NNP
cord-260476-whfyczcj	40	28	or	or	CC
cord-260476-whfyczcj	40	29	H7N9	H7N9	NNP
cord-260476-whfyczcj	40	30	)	)	-RRB-
cord-260476-whfyczcj	40	31	associate	associate	VB
cord-260476-whfyczcj	40	32	with	with	IN
cord-260476-whfyczcj	40	33	TRIM32	trim32	RB
cord-260476-whfyczcj	40	34	in	in	IN
cord-260476-whfyczcj	40	35	multiple	multiple	JJ
cord-260476-whfyczcj	40	36	cell	cell	NN
cord-260476-whfyczcj	40	37	types	type	NNS
cord-260476-whfyczcj	40	38	and	and	CC
cord-260476-whfyczcj	40	39	this	this	DT
cord-260476-whfyczcj	40	40	suggests	suggest	VBZ
cord-260476-whfyczcj	40	41	that	that	IN
cord-260476-whfyczcj	40	42	PB1	pb1	NN
cord-260476-whfyczcj	40	43	has	have	VBZ
cord-260476-whfyczcj	40	44	not	not	RB
cord-260476-whfyczcj	40	45	yet	yet	RB
cord-260476-whfyczcj	40	46	adapted	adapt	VBN
cord-260476-whfyczcj	40	47	to	to	TO
cord-260476-whfyczcj	40	48	avoid	avoid	VB
cord-260476-whfyczcj	40	49	TRIM32	trim32	DT
cord-260476-whfyczcj	40	50	targeting	target	VBG
cord-260476-whfyczcj	40	51	[	[	-LRB-
cord-260476-whfyczcj	40	52	28	28	CD
cord-260476-whfyczcj	40	53	]	]	-RRB-
cord-260476-whfyczcj	40	54	.	.	.
cord-260476-whfyczcj	41	1	The	the	DT
cord-260476-whfyczcj	41	2	Human	Human	NNP
cord-260476-whfyczcj	41	3	herpesvirus	herpesvirus	NN
cord-260476-whfyczcj	41	4	type	type	NN
cord-260476-whfyczcj	41	5	I	-PRON-	PRP
cord-260476-whfyczcj	41	6	(	(	-LRB-
cord-260476-whfyczcj	41	7	HSV-1	hsv-1	NN
cord-260476-whfyczcj	41	8	)	)	-RRB-
cord-260476-whfyczcj	41	9	capsid	capsid	NN
cord-260476-whfyczcj	41	10	protein	protein	NN
cord-260476-whfyczcj	41	11	Vp5	vp5	NN
cord-260476-whfyczcj	41	12	has	have	VBZ
cord-260476-whfyczcj	41	13	also	also	RB
cord-260476-whfyczcj	41	14	been	be	VBN
cord-260476-whfyczcj	41	15	shown	show	VBN
cord-260476-whfyczcj	41	16	to	to	TO
cord-260476-whfyczcj	41	17	be	be	VB
cord-260476-whfyczcj	41	18	degraded	degrade	VBN
cord-260476-whfyczcj	41	19	by	by	IN
cord-260476-whfyczcj	41	20	the	the	DT
cord-260476-whfyczcj	41	21	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	41	22	proteasome	proteasome	NN
cord-260476-whfyczcj	41	23	system	system	NN
cord-260476-whfyczcj	41	24	,	,	,
cord-260476-whfyczcj	41	25	leaving	leave	VBG
cord-260476-whfyczcj	41	26	the	the	DT
cord-260476-whfyczcj	41	27	viral	viral	JJ
cord-260476-whfyczcj	41	28	genome	genome	NN
cord-260476-whfyczcj	41	29	exposed	expose	VBN
cord-260476-whfyczcj	41	30	to	to	IN
cord-260476-whfyczcj	41	31	innate	innate	JJ
cord-260476-whfyczcj	41	32	immune	immune	JJ
cord-260476-whfyczcj	41	33	sensors	sensor	NNS
cord-260476-whfyczcj	41	34	[	[	-LRB-
cord-260476-whfyczcj	41	35	29	29	CD
cord-260476-whfyczcj	41	36	]	]	-RRB-
cord-260476-whfyczcj	41	37	.	.	.
cord-260476-whfyczcj	42	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	42	2	,	,	,
cord-260476-whfyczcj	42	3	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	42	4	was	be	VBD
cord-260476-whfyczcj	42	5	reported	report	VBN
cord-260476-whfyczcj	42	6	to	to	TO
cord-260476-whfyczcj	42	7	inhibit	inhibit	VB
cord-260476-whfyczcj	42	8	HSV-1	hsv-1	NN
cord-260476-whfyczcj	42	9	and	and	CC
cord-260476-whfyczcj	42	10	-2	-2	CD
cord-260476-whfyczcj	42	11	replication	replication	NN
cord-260476-whfyczcj	42	12	at	at	IN
cord-260476-whfyczcj	42	13	an	an	DT
cord-260476-whfyczcj	42	14	early	early	JJ
cord-260476-whfyczcj	42	15	stage	stage	NN
cord-260476-whfyczcj	42	16	of	of	IN
cord-260476-whfyczcj	42	17	the	the	DT
cord-260476-whfyczcj	42	18	infection	infection	NN
cord-260476-whfyczcj	42	19	cycle	cycle	NN
cord-260476-whfyczcj	42	20	[	[	-LRB-
cord-260476-whfyczcj	42	21	30	30	CD
cord-260476-whfyczcj	42	22	]	]	-RRB-
cord-260476-whfyczcj	42	23	,	,	,
cord-260476-whfyczcj	42	24	suggesting	suggest	VBG
cord-260476-whfyczcj	42	25	a	a	DT
cord-260476-whfyczcj	42	26	role	role	NN
cord-260476-whfyczcj	42	27	for	for	IN
cord-260476-whfyczcj	42	28	this	this	DT
cord-260476-whfyczcj	42	29	or	or	CC
cord-260476-whfyczcj	42	30	related	related	JJ
cord-260476-whfyczcj	42	31	protein	protein	NN
cord-260476-whfyczcj	42	32	in	in	IN
cord-260476-whfyczcj	42	33	cytosolic	cytosolic	JJ
cord-260476-whfyczcj	42	34	sensing	sensing	NN
cord-260476-whfyczcj	42	35	of	of	IN
cord-260476-whfyczcj	42	36	herpesvirus	herpesvirus	NNP
cord-260476-whfyczcj	42	37	capsids	capsid	NNS
cord-260476-whfyczcj	42	38	.	.	.
cord-260476-whfyczcj	43	1	(	(	-LRB-
cord-260476-whfyczcj	43	2	3	3	LS
cord-260476-whfyczcj	43	3	)	)	-RRB-
cord-260476-whfyczcj	44	1	Certain	certain	JJ
cord-260476-whfyczcj	44	2	viruses	virus	NNS
cord-260476-whfyczcj	44	3	have	have	VBP
cord-260476-whfyczcj	44	4	evolved	evolve	VBN
cord-260476-whfyczcj	44	5	to	to	TO
cord-260476-whfyczcj	44	6	recruit	recruit	VB
cord-260476-whfyczcj	44	7	the	the	DT
cord-260476-whfyczcj	44	8	cellular	cellular	JJ
cord-260476-whfyczcj	44	9	E3	e3	NN
cord-260476-whfyczcj	44	10	ligases	ligase	NNS
cord-260476-whfyczcj	44	11	to	to	TO
cord-260476-whfyczcj	44	12	induce	induce	VB
cord-260476-whfyczcj	44	13	the	the	DT
cord-260476-whfyczcj	44	14	degradation	degradation	NN
cord-260476-whfyczcj	44	15	of	of	IN
cord-260476-whfyczcj	44	16	cellular	cellular	JJ
cord-260476-whfyczcj	44	17	proteins	protein	NNS
cord-260476-whfyczcj	44	18	that	that	WDT
cord-260476-whfyczcj	44	19	might	may	MD
cord-260476-whfyczcj	44	20	have	have	VB
cord-260476-whfyczcj	44	21	harmful	harmful	JJ
cord-260476-whfyczcj	44	22	effects	effect	NNS
cord-260476-whfyczcj	44	23	on	on	IN
cord-260476-whfyczcj	44	24	the	the	DT
cord-260476-whfyczcj	44	25	viral	viral	JJ
cord-260476-whfyczcj	44	26	life	life	NN
cord-260476-whfyczcj	44	27	cycle	cycle	NN
cord-260476-whfyczcj	44	28	.	.	.
cord-260476-whfyczcj	45	1	For	for	IN
cord-260476-whfyczcj	45	2	instance	instance	NN
cord-260476-whfyczcj	45	3	,	,	,
cord-260476-whfyczcj	45	4	the	the	DT
cord-260476-whfyczcj	45	5	protein	protein	NN
cord-260476-whfyczcj	45	6	E6	E6	NNP
cord-260476-whfyczcj	45	7	of	of	IN
cord-260476-whfyczcj	45	8	Human	human	JJ
cord-260476-whfyczcj	45	9	papillomavirus	papillomavirus	NN
cord-260476-whfyczcj	45	10	(	(	-LRB-
cord-260476-whfyczcj	45	11	HPV	HPV	NNP
cord-260476-whfyczcj	45	12	)	)	-RRB-
cord-260476-whfyczcj	45	13	recruits	recruit	VBZ
cord-260476-whfyczcj	45	14	the	the	DT
cord-260476-whfyczcj	45	15	cellular	cellular	JJ
cord-260476-whfyczcj	45	16	E3	e3	NN
cord-260476-whfyczcj	45	17	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	45	18	ligase	ligase	NN
cord-260476-whfyczcj	45	19	E6-AP	E6-AP	NNP
cord-260476-whfyczcj	45	20	to	to	TO
cord-260476-whfyczcj	45	21	induce	induce	VB
cord-260476-whfyczcj	45	22	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	45	23	and	and	CC
cord-260476-whfyczcj	45	24	degradation	degradation	NN
cord-260476-whfyczcj	45	25	of	of	IN
cord-260476-whfyczcj	45	26	p53	p53	NN
cord-260476-whfyczcj	45	27	,	,	,
cord-260476-whfyczcj	45	28	thereby	thereby	RB
cord-260476-whfyczcj	45	29	allowing	allow	VBG
cord-260476-whfyczcj	45	30	viral	viral	JJ
cord-260476-whfyczcj	45	31	replication	replication	NN
cord-260476-whfyczcj	45	32	[	[	-LRB-
cord-260476-whfyczcj	45	33	31	31	CD
cord-260476-whfyczcj	45	34	,	,	,
cord-260476-whfyczcj	45	35	32	32	CD
cord-260476-whfyczcj	45	36	]	]	-RRB-
cord-260476-whfyczcj	45	37	.	.	.
cord-260476-whfyczcj	46	1	The	the	DT
cord-260476-whfyczcj	46	2	NSP1	NSP1	NNP
cord-260476-whfyczcj	46	3	(	(	-LRB-
cord-260476-whfyczcj	46	4	Non	Non	NNP
cord-260476-whfyczcj	46	5	-	-	NNP
cord-260476-whfyczcj	46	6	Structural	structural	JJ
cord-260476-whfyczcj	46	7	RNA	RNA	NNP
cord-260476-whfyczcj	46	8	binding	bind	VBG
cord-260476-whfyczcj	46	9	protein	protein	NN
cord-260476-whfyczcj	46	10	1	1	CD
cord-260476-whfyczcj	46	11	)	)	-RRB-
cord-260476-whfyczcj	46	12	protein	protein	NN
cord-260476-whfyczcj	46	13	of	of	IN
cord-260476-whfyczcj	46	14	Rotaviruses	Rotaviruses	NNP
cord-260476-whfyczcj	46	15	subverts	subvert	VBZ
cord-260476-whfyczcj	46	16	the	the	DT
cord-260476-whfyczcj	46	17	Skp1-Cul1-Fbox	skp1-cul1-fbox	NN
cord-260476-whfyczcj	46	18	(	(	-LRB-
cord-260476-whfyczcj	46	19	SCF	SCF	NNP
cord-260476-whfyczcj	46	20	)	)	-RRB-
cord-260476-whfyczcj	46	21	E3	e3	NN
cord-260476-whfyczcj	46	22	ligase	ligase	NN
cord-260476-whfyczcj	46	23	to	to	TO
cord-260476-whfyczcj	46	24	induce	induce	VB
cord-260476-whfyczcj	46	25	the	the	DT
cord-260476-whfyczcj	46	26	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	46	27	and	and	CC
cord-260476-whfyczcj	46	28	degradation	degradation	NN
cord-260476-whfyczcj	46	29	of	of	IN
cord-260476-whfyczcj	46	30	β	β	NN
cord-260476-whfyczcj	46	31	-	-	HYPH
cord-260476-whfyczcj	46	32	TrCP	TrCP	NNP
cord-260476-whfyczcj	46	33	(	(	-LRB-
cord-260476-whfyczcj	46	34	β	β	NN
cord-260476-whfyczcj	46	35	-	-	HYPH
cord-260476-whfyczcj	46	36	Transducin	Transducin	NNP
cord-260476-whfyczcj	46	37	repeat	repeat	NN
cord-260476-whfyczcj	46	38	Containing	contain	VBG
cord-260476-whfyczcj	46	39	Protein	Protein	NNP
cord-260476-whfyczcj	46	40	)	)	-RRB-
cord-260476-whfyczcj	46	41	.	.	.
cord-260476-whfyczcj	47	1	β	β	NN
cord-260476-whfyczcj	47	2	-	-	HYPH
cord-260476-whfyczcj	47	3	TrCP	TrCP	NNP
cord-260476-whfyczcj	47	4	is	be	VBZ
cord-260476-whfyczcj	47	5	by	by	IN
cord-260476-whfyczcj	47	6	itself	-PRON-	PRP
cord-260476-whfyczcj	47	7	a	a	DT
cord-260476-whfyczcj	47	8	substrate	substrate	JJ
cord-260476-whfyczcj	47	9	adaptor	adaptor	NN
cord-260476-whfyczcj	47	10	of	of	IN
cord-260476-whfyczcj	47	11	an	an	DT
cord-260476-whfyczcj	47	12	E3	e3	NN
cord-260476-whfyczcj	47	13	ligase	ligase	NN
cord-260476-whfyczcj	47	14	and	and	CC
cord-260476-whfyczcj	47	15	its	-PRON-	PRP$
cord-260476-whfyczcj	47	16	degradation	degradation	NN
cord-260476-whfyczcj	47	17	leads	lead	VBZ
cord-260476-whfyczcj	47	18	to	to	IN
cord-260476-whfyczcj	47	19	accumulation	accumulation	NN
cord-260476-whfyczcj	47	20	of	of	IN
cord-260476-whfyczcj	47	21	the	the	DT
cord-260476-whfyczcj	47	22	NF	nf	NN
cord-260476-whfyczcj	47	23	-	-	HYPH
cord-260476-whfyczcj	47	24	κB	κb	CD
cord-260476-whfyczcj	47	25	inhibitor	inhibitor	NN
cord-260476-whfyczcj	47	26	IκB	iκb	NN
cord-260476-whfyczcj	47	27	,	,	,
cord-260476-whfyczcj	47	28	resulting	result	VBG
cord-260476-whfyczcj	47	29	in	in	IN
cord-260476-whfyczcj	47	30	inhibition	inhibition	NN
cord-260476-whfyczcj	47	31	of	of	IN
cord-260476-whfyczcj	48	1	the	the	DT
cord-260476-whfyczcj	48	2	NF	NF	NNP
cord-260476-whfyczcj	48	3	-	-	HYPH
cord-260476-whfyczcj	48	4	κB	κB	NNP
cord-260476-whfyczcj	48	5	induced	induce	VBN
cord-260476-whfyczcj	48	6	antiviral	antiviral	JJ
cord-260476-whfyczcj	48	7	responses	response	NNS
cord-260476-whfyczcj	48	8	[	[	-LRB-
cord-260476-whfyczcj	48	9	33	33	CD
cord-260476-whfyczcj	48	10	,	,	,
cord-260476-whfyczcj	48	11	34	34	CD
cord-260476-whfyczcj	48	12	]	]	-RRB-
cord-260476-whfyczcj	48	13	.	.	.
cord-260476-whfyczcj	49	1	These	these	DT
cord-260476-whfyczcj	49	2	mechanisms	mechanism	NNS
cord-260476-whfyczcj	49	3	are	be	VBP
cord-260476-whfyczcj	49	4	important	important	JJ
cord-260476-whfyczcj	49	5	for	for	IN
cord-260476-whfyczcj	49	6	HIV	HIV	NNP
cord-260476-whfyczcj	49	7	replication	replication	NN
cord-260476-whfyczcj	49	8	and	and	CC
cord-260476-whfyczcj	49	9	will	will	MD
cord-260476-whfyczcj	49	10	be	be	VB
cord-260476-whfyczcj	49	11	detailed	detail	VBN
cord-260476-whfyczcj	49	12	in	in	IN
cord-260476-whfyczcj	49	13	Section	section	NN
cord-260476-whfyczcj	49	14	5	5	CD
cord-260476-whfyczcj	49	15	.	.	.
cord-260476-whfyczcj	50	1	(	(	-LRB-
cord-260476-whfyczcj	50	2	4	4	LS
cord-260476-whfyczcj	50	3	)	)	-RRB-
cord-260476-whfyczcj	51	1	Other	other	JJ
cord-260476-whfyczcj	51	2	viruses	virus	NNS
cord-260476-whfyczcj	51	3	directly	directly	RB
cord-260476-whfyczcj	51	4	encode	encode	VBP
cord-260476-whfyczcj	51	5	their	-PRON-	PRP$
cord-260476-whfyczcj	51	6	own	own	JJ
cord-260476-whfyczcj	51	7	E3	e3	NN
cord-260476-whfyczcj	51	8	ligases	ligase	NNS
cord-260476-whfyczcj	51	9	.	.	.
cord-260476-whfyczcj	52	1	Kaposi	Kaposi	NNP
cord-260476-whfyczcj	52	2	sarcoma	sarcoma	NN
cord-260476-whfyczcj	52	3	herpesvirus	herpesvirus	NN
cord-260476-whfyczcj	52	4	(	(	-LRB-
cord-260476-whfyczcj	52	5	KSHV	KSHV	NNP
cord-260476-whfyczcj	52	6	)	)	-RRB-
cord-260476-whfyczcj	52	7	protein	protein	NN
cord-260476-whfyczcj	52	8	K3	K3	NNP
cord-260476-whfyczcj	52	9	and	and	CC
cord-260476-whfyczcj	52	10	K5	K5	NNP
cord-260476-whfyczcj	52	11	(	(	-LRB-
cord-260476-whfyczcj	52	12	RING	ring	NN
cord-260476-whfyczcj	52	13	-	-	HYPH
cord-260476-whfyczcj	52	14	CH	ch	NN
cord-260476-whfyczcj	52	15	family	family	NN
cord-260476-whfyczcj	52	16	of	of	IN
cord-260476-whfyczcj	52	17	ligases	ligase	NNS
cord-260476-whfyczcj	52	18	)	)	-RRB-
cord-260476-whfyczcj	53	1	ubiquitinate	ubiquitinate	NNP
cord-260476-whfyczcj	53	2	MHC	MHC	NNP
cord-260476-whfyczcj	54	1	-I	-I	NFP
cord-260476-whfyczcj	54	2	(	(	-LRB-
cord-260476-whfyczcj	54	3	Major	Major	NNP
cord-260476-whfyczcj	54	4	Histocompatibility	Histocompatibility	NNP
cord-260476-whfyczcj	54	5	Complex	Complex	NNP
cord-260476-whfyczcj	54	6	I	I	NNP
cord-260476-whfyczcj	54	7	)	)	-RRB-
cord-260476-whfyczcj	54	8	,	,	,
cord-260476-whfyczcj	54	9	resulting	result	VBG
cord-260476-whfyczcj	54	10	in	in	IN
cord-260476-whfyczcj	54	11	its	-PRON-	PRP$
cord-260476-whfyczcj	54	12	down	down	JJ
cord-260476-whfyczcj	54	13	-	-	HYPH
cord-260476-whfyczcj	54	14	regulation	regulation	NN
cord-260476-whfyczcj	54	15	from	from	IN
cord-260476-whfyczcj	54	16	the	the	DT
cord-260476-whfyczcj	54	17	cell	cell	NN
cord-260476-whfyczcj	54	18	surface	surface	NN
cord-260476-whfyczcj	54	19	through	through	IN
cord-260476-whfyczcj	54	20	a	a	DT
cord-260476-whfyczcj	54	21	clathrin	clathrin	NN
cord-260476-whfyczcj	54	22	-	-	HYPH
cord-260476-whfyczcj	54	23	dependent	dependent	JJ
cord-260476-whfyczcj	54	24	sorting	sorting	NN
cord-260476-whfyczcj	54	25	pathway	pathway	NN
cord-260476-whfyczcj	54	26	to	to	IN
cord-260476-whfyczcj	54	27	an	an	DT
cord-260476-whfyczcj	54	28	endolysosomal	endolysosomal	JJ
cord-260476-whfyczcj	54	29	compartment	compartment	NN
cord-260476-whfyczcj	54	30	[	[	-LRB-
cord-260476-whfyczcj	54	31	35	35	CD
cord-260476-whfyczcj	54	32	,	,	,
cord-260476-whfyczcj	54	33	36	36	CD
cord-260476-whfyczcj	54	34	]	]	-RRB-
cord-260476-whfyczcj	54	35	.	.	.
cord-260476-whfyczcj	55	1	This	this	DT
cord-260476-whfyczcj	55	2	endolysosomal	endolysosomal	NN
cord-260476-whfyczcj	55	3	sorting	sorting	NN
cord-260476-whfyczcj	55	4	requires	require	VBZ
cord-260476-whfyczcj	55	5	K63-linked	k63-linke	VBN
cord-260476-whfyczcj	55	6	instead	instead	RB
cord-260476-whfyczcj	55	7	of	of	IN
cord-260476-whfyczcj	55	8	K48-linked	K48-linked	NNP
cord-260476-whfyczcj	55	9	polyubiquitin	polyubiquitin	NNP
cord-260476-whfyczcj	55	10	chains	chain	NNS
cord-260476-whfyczcj	55	11	[	[	-LRB-
cord-260476-whfyczcj	55	12	19	19	CD
cord-260476-whfyczcj	55	13	]	]	-RRB-
cord-260476-whfyczcj	55	14	.	.	.
cord-260476-whfyczcj	56	1	Another	another	DT
cord-260476-whfyczcj	56	2	well	well	RB
cord-260476-whfyczcj	56	3	-	-	HYPH
cord-260476-whfyczcj	56	4	known	know	VBN
cord-260476-whfyczcj	56	5	example	example	NN
cord-260476-whfyczcj	56	6	is	be	VBZ
cord-260476-whfyczcj	56	7	the	the	DT
cord-260476-whfyczcj	56	8	ICP0	ICP0	NNP
cord-260476-whfyczcj	56	9	protein	protein	NN
cord-260476-whfyczcj	56	10	(	(	-LRB-
cord-260476-whfyczcj	56	11	Infected	Infected	NNP
cord-260476-whfyczcj	56	12	Cell	Cell	NNP
cord-260476-whfyczcj	56	13	Protein	Protein	NNP
cord-260476-whfyczcj	56	14	0	0	CD
cord-260476-whfyczcj	56	15	)	)	-RRB-
cord-260476-whfyczcj	56	16	of	of	IN
cord-260476-whfyczcj	56	17	HSV-1	HSV-1	NNP
cord-260476-whfyczcj	56	18	,	,	,
cord-260476-whfyczcj	56	19	an	an	DT
cord-260476-whfyczcj	56	20	E3	e3	NN
cord-260476-whfyczcj	56	21	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	56	22	ligase	ligase	NN
cord-260476-whfyczcj	56	23	which	which	WDT
cord-260476-whfyczcj	56	24	induces	induce	VBZ
cord-260476-whfyczcj	56	25	the	the	DT
cord-260476-whfyczcj	56	26	degradation	degradation	NN
cord-260476-whfyczcj	56	27	of	of	IN
cord-260476-whfyczcj	56	28	the	the	DT
cord-260476-whfyczcj	56	29	ND10	ND10	NNP
cord-260476-whfyczcj	56	30	(	(	-LRB-
cord-260476-whfyczcj	56	31	Nuclear	Nuclear	NNP
cord-260476-whfyczcj	56	32	Domain	Domain	NNP
cord-260476-whfyczcj	56	33	10	10	CD
cord-260476-whfyczcj	56	34	)	)	-RRB-
cord-260476-whfyczcj	56	35	nuclear	nuclear	JJ
cord-260476-whfyczcj	56	36	body	body	NN
cord-260476-whfyczcj	56	37	components	component	NNS
cord-260476-whfyczcj	56	38	PML	PML	NNP
cord-260476-whfyczcj	56	39	(	(	-LRB-
cord-260476-whfyczcj	56	40	Promyelocytic	Promyelocytic	NNP
cord-260476-whfyczcj	56	41	Leukemia	Leukemia	NNP
cord-260476-whfyczcj	56	42	Protein	Protein	NNP
cord-260476-whfyczcj	56	43	)	)	-RRB-
cord-260476-whfyczcj	56	44	and	and	CC
cord-260476-whfyczcj	56	45	Sp100	Sp100	NNS
cord-260476-whfyczcj	56	46	through	through	IN
cord-260476-whfyczcj	56	47	the	the	DT
cord-260476-whfyczcj	56	48	UPS	up	NNS
cord-260476-whfyczcj	56	49	,	,	,
cord-260476-whfyczcj	56	50	thereby	thereby	RB
cord-260476-whfyczcj	56	51	avoiding	avoid	VBG
cord-260476-whfyczcj	56	52	antiviral	antiviral	JJ
cord-260476-whfyczcj	56	53	sensing	sensing	NN
cord-260476-whfyczcj	56	54	[	[	-LRB-
cord-260476-whfyczcj	56	55	37	37	CD
cord-260476-whfyczcj	56	56	,	,	,
cord-260476-whfyczcj	56	57	38	38	CD
cord-260476-whfyczcj	56	58	]	]	-RRB-
cord-260476-whfyczcj	56	59	.	.	.
cord-260476-whfyczcj	57	1	ICP0	ICP0	NNP
cord-260476-whfyczcj	57	2	has	have	VBZ
cord-260476-whfyczcj	57	3	also	also	RB
cord-260476-whfyczcj	57	4	been	be	VBN
cord-260476-whfyczcj	57	5	shown	show	VBN
cord-260476-whfyczcj	57	6	to	to	TO
cord-260476-whfyczcj	57	7	have	have	VB
cord-260476-whfyczcj	57	8	a	a	DT
cord-260476-whfyczcj	57	9	RING	ring	NN
cord-260476-whfyczcj	57	10	-	-	HYPH
cord-260476-whfyczcj	57	11	independent	independent	JJ
cord-260476-whfyczcj	57	12	E3	e3	NN
cord-260476-whfyczcj	57	13	ligase	ligase	NN
cord-260476-whfyczcj	57	14	activity	activity	NN
cord-260476-whfyczcj	57	15	that	that	WDT
cord-260476-whfyczcj	57	16	polyubiquitinates	polyubiquitinate	VBZ
cord-260476-whfyczcj	57	17	the	the	DT
cord-260476-whfyczcj	57	18	E2	E2	NNP
cord-260476-whfyczcj	57	19	enzyme	enzyme	NN
cord-260476-whfyczcj	58	1	cdc34	cdc34	NNP
cord-260476-whfyczcj	58	2	.	.	.
cord-260476-whfyczcj	59	1	ICP0	ICP0	NNP
cord-260476-whfyczcj	59	2	influences	influence	VBZ
cord-260476-whfyczcj	59	3	many	many	JJ
cord-260476-whfyczcj	59	4	cellular	cellular	JJ
cord-260476-whfyczcj	59	5	pathways	pathway	NNS
cord-260476-whfyczcj	59	6	and	and	CC
cord-260476-whfyczcj	59	7	is	be	VBZ
cord-260476-whfyczcj	59	8	required	require	VBN
cord-260476-whfyczcj	59	9	for	for	IN
cord-260476-whfyczcj	59	10	the	the	DT
cord-260476-whfyczcj	59	11	activation	activation	NN
cord-260476-whfyczcj	59	12	of	of	IN
cord-260476-whfyczcj	59	13	most	most	RBS
cord-260476-whfyczcj	59	14	viral	viral	JJ
cord-260476-whfyczcj	59	15	and	and	CC
cord-260476-whfyczcj	59	16	many	many	JJ
cord-260476-whfyczcj	59	17	cellular	cellular	JJ
cord-260476-whfyczcj	59	18	genes	gene	NNS
cord-260476-whfyczcj	59	19	,	,	,
cord-260476-whfyczcj	59	20	for	for	IN
cord-260476-whfyczcj	59	21	reactivation	reactivation	NN
cord-260476-whfyczcj	59	22	from	from	IN
cord-260476-whfyczcj	59	23	latency	latency	NN
cord-260476-whfyczcj	59	24	and	and	CC
cord-260476-whfyczcj	59	25	suppression	suppression	NN
cord-260476-whfyczcj	59	26	of	of	IN
cord-260476-whfyczcj	59	27	innate	innate	JJ
cord-260476-whfyczcj	59	28	immunity	immunity	NN
cord-260476-whfyczcj	59	29	[	[	-LRB-
cord-260476-whfyczcj	59	30	19	19	CD
cord-260476-whfyczcj	59	31	]	]	-RRB-
cord-260476-whfyczcj	59	32	.	.	.
cord-260476-whfyczcj	60	1	(	(	-LRB-
cord-260476-whfyczcj	60	2	5	5	LS
cord-260476-whfyczcj	60	3	)	)	-RRB-
cord-260476-whfyczcj	61	1	Finally	finally	RB
cord-260476-whfyczcj	61	2	,	,	,
cord-260476-whfyczcj	61	3	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	61	4	modifications	modification	NNS
cord-260476-whfyczcj	61	5	can	can	MD
cord-260476-whfyczcj	61	6	be	be	VB
cord-260476-whfyczcj	61	7	reversed	reverse	VBN
cord-260476-whfyczcj	61	8	by	by	IN
cord-260476-whfyczcj	61	9	the	the	DT
cord-260476-whfyczcj	61	10	isopeptide	isopeptide	NN
cord-260476-whfyczcj	61	11	-	-	HYPH
cord-260476-whfyczcj	61	12	bond	bond	NN
cord-260476-whfyczcj	61	13	specific	specific	JJ
cord-260476-whfyczcj	61	14	proteolytic	proteolytic	JJ
cord-260476-whfyczcj	61	15	activity	activity	NN
cord-260476-whfyczcj	61	16	of	of	IN
cord-260476-whfyczcj	61	17	DUBs	dub	NNS
cord-260476-whfyczcj	61	18	.	.	.
cord-260476-whfyczcj	62	1	In	in	IN
cord-260476-whfyczcj	62	2	addition	addition	NN
cord-260476-whfyczcj	62	3	to	to	IN
cord-260476-whfyczcj	62	4	cellular	cellular	JJ
cord-260476-whfyczcj	62	5	DUBs	dub	NNS
cord-260476-whfyczcj	62	6	,	,	,
cord-260476-whfyczcj	62	7	it	-PRON-	PRP
cord-260476-whfyczcj	62	8	has	have	VBZ
cord-260476-whfyczcj	62	9	been	be	VBN
cord-260476-whfyczcj	62	10	reported	report	VBN
cord-260476-whfyczcj	62	11	that	that	IN
cord-260476-whfyczcj	62	12	various	various	JJ
cord-260476-whfyczcj	62	13	virus	virus	NN
cord-260476-whfyczcj	62	14	families	family	NNS
cord-260476-whfyczcj	62	15	code	code	VBP
cord-260476-whfyczcj	62	16	their	-PRON-	PRP$
cord-260476-whfyczcj	62	17	own	own	JJ
cord-260476-whfyczcj	62	18	DUBs	dub	NNS
cord-260476-whfyczcj	62	19	(	(	-LRB-
cord-260476-whfyczcj	62	20	Coronavirus	Coronavirus	NNP
cord-260476-whfyczcj	62	21	,	,	,
cord-260476-whfyczcj	62	22	Herpesvirus	Herpesvirus	NNP
cord-260476-whfyczcj	62	23	etc	etc	FW
cord-260476-whfyczcj	62	24	.	.	.
cord-260476-whfyczcj	62	25	)	)	-RRB-
cord-260476-whfyczcj	62	26	to	to	TO
cord-260476-whfyczcj	62	27	evade	evade	VB
cord-260476-whfyczcj	62	28	host	host	NN
cord-260476-whfyczcj	62	29	antiviral	antiviral	JJ
cord-260476-whfyczcj	62	30	immune	immune	JJ
cord-260476-whfyczcj	62	31	response	response	NN
cord-260476-whfyczcj	62	32	and	and	CC
cord-260476-whfyczcj	62	33	promote	promote	VB
cord-260476-whfyczcj	62	34	virus	virus	NN
cord-260476-whfyczcj	62	35	replication	replication	NN
cord-260476-whfyczcj	62	36	(	(	-LRB-
cord-260476-whfyczcj	62	37	for	for	IN
cord-260476-whfyczcj	62	38	a	a	DT
cord-260476-whfyczcj	62	39	recent	recent	JJ
cord-260476-whfyczcj	62	40	review	review	NN
cord-260476-whfyczcj	62	41	see	see	VBP
cord-260476-whfyczcj	62	42	[	[	-LRB-
cord-260476-whfyczcj	62	43	1	1	CD
cord-260476-whfyczcj	62	44	]	]	-RRB-
cord-260476-whfyczcj	62	45	)	)	-RRB-
cord-260476-whfyczcj	62	46	.	.	.
cord-260476-whfyczcj	63	1	For	for	IN
cord-260476-whfyczcj	63	2	instance	instance	NN
cord-260476-whfyczcj	63	3	,	,	,
cord-260476-whfyczcj	63	4	in	in	IN
cord-260476-whfyczcj	63	5	the	the	DT
cord-260476-whfyczcj	63	6	herpesviridae	herpesviridae	NN
cord-260476-whfyczcj	63	7	family	family	NN
cord-260476-whfyczcj	63	8	,	,	,
cord-260476-whfyczcj	63	9	a	a	DT
cord-260476-whfyczcj	63	10	variety	variety	NN
cord-260476-whfyczcj	63	11	of	of	IN
cord-260476-whfyczcj	63	12	DUBs	dub	NNS
cord-260476-whfyczcj	63	13	play	play	VBP
cord-260476-whfyczcj	63	14	an	an	DT
cord-260476-whfyczcj	63	15	important	important	JJ
cord-260476-whfyczcj	63	16	role	role	NN
cord-260476-whfyczcj	63	17	in	in	IN
cord-260476-whfyczcj	63	18	the	the	DT
cord-260476-whfyczcj	63	19	virus	virus	NN
cord-260476-whfyczcj	63	20	life	life	NN
cord-260476-whfyczcj	63	21	cycle	cycle	NN
cord-260476-whfyczcj	63	22	(	(	-LRB-
cord-260476-whfyczcj	63	23	e.g.	e.g.	RB
cord-260476-whfyczcj	63	24	,	,	,
cord-260476-whfyczcj	63	25	UL36USP	ul36usp	JJ
cord-260476-whfyczcj	63	26	(	(	-LRB-
cord-260476-whfyczcj	63	27	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	63	28	Ligase	Ligase	NNP
cord-260476-whfyczcj	63	29	36	36	CD
cord-260476-whfyczcj	63	30	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	63	31	Specific	Specific	NNP
cord-260476-whfyczcj	63	32	Protease	Protease	NNP
cord-260476-whfyczcj	63	33	)	)	-RRB-
cord-260476-whfyczcj	63	34	of	of	IN
cord-260476-whfyczcj	63	35	HSV-1	HSV-1	NNP
cord-260476-whfyczcj	63	36	,	,	,
cord-260476-whfyczcj	63	37	tegument	tegument	NN
cord-260476-whfyczcj	63	38	protein	protein	NNP
cord-260476-whfyczcj	63	39	pUL48	pUL48	NNP
cord-260476-whfyczcj	63	40	of	of	IN
cord-260476-whfyczcj	63	41	human	human	JJ
cord-260476-whfyczcj	63	42	cytomegalovirus	cytomegalovirus	NNP
cord-260476-whfyczcj	63	43	(	(	-LRB-
cord-260476-whfyczcj	63	44	HCMV	HCMV	NNP
cord-260476-whfyczcj	63	45	)	)	-RRB-
cord-260476-whfyczcj	63	46	)	)	-RRB-
cord-260476-whfyczcj	63	47	.	.	.
cord-260476-whfyczcj	64	1	Regarding	regard	VBG
cord-260476-whfyczcj	64	2	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	64	3	,	,	,
cord-260476-whfyczcj	64	4	a	a	DT
cord-260476-whfyczcj	64	5	recent	recent	JJ
cord-260476-whfyczcj	64	6	study	study	NN
cord-260476-whfyczcj	64	7	reported	report	VBD
cord-260476-whfyczcj	64	8	that	that	IN
cord-260476-whfyczcj	64	9	several	several	JJ
cord-260476-whfyczcj	64	10	cellular	cellular	JJ
cord-260476-whfyczcj	64	11	DUBs	dub	NNS
cord-260476-whfyczcj	64	12	(	(	-LRB-
cord-260476-whfyczcj	64	13	USP7	USP7	NNP
cord-260476-whfyczcj	64	14	and	and	CC
cord-260476-whfyczcj	64	15	USP47	USP47	NNP
cord-260476-whfyczcj	64	16	,	,	,
cord-260476-whfyczcj	64	17	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	64	18	Specific	Specific	NNP
cord-260476-whfyczcj	64	19	Protease	Protease	NNP
cord-260476-whfyczcj	64	20	family	family	NN
cord-260476-whfyczcj	64	21	)	)	-RRB-
cord-260476-whfyczcj	64	22	play	play	VB
cord-260476-whfyczcj	64	23	an	an	DT
cord-260476-whfyczcj	64	24	important	important	JJ
cord-260476-whfyczcj	64	25	role	role	NN
cord-260476-whfyczcj	64	26	in	in	IN
cord-260476-whfyczcj	64	27	its	-PRON-	PRP$
cord-260476-whfyczcj	64	28	replication	replication	NN
cord-260476-whfyczcj	64	29	by	by	IN
cord-260476-whfyczcj	64	30	regulating	regulate	VBG
cord-260476-whfyczcj	64	31	Gag	gag	NN
cord-260476-whfyczcj	64	32	processing	processing	NN
cord-260476-whfyczcj	64	33	and	and	CC
cord-260476-whfyczcj	64	34	thus	thus	RB
cord-260476-whfyczcj	64	35	the	the	DT
cord-260476-whfyczcj	64	36	infectivity	infectivity	NN
cord-260476-whfyczcj	64	37	of	of	IN
cord-260476-whfyczcj	64	38	released	release	VBN
cord-260476-whfyczcj	64	39	virions	virion	NNS
cord-260476-whfyczcj	64	40	and	and	CC
cord-260476-whfyczcj	64	41	simultaneously	simultaneously	RB
cord-260476-whfyczcj	64	42	the	the	DT
cord-260476-whfyczcj	64	43	entry	entry	NN
cord-260476-whfyczcj	64	44	of	of	IN
cord-260476-whfyczcj	64	45	Gag	Gag	NNP
cord-260476-whfyczcj	64	46	into	into	IN
cord-260476-whfyczcj	64	47	the	the	DT
cord-260476-whfyczcj	64	48	UPS	UPS	NNP
cord-260476-whfyczcj	64	49	and	and	CC
cord-260476-whfyczcj	64	50	MHC	MHC	NNP
cord-260476-whfyczcj	64	51	-	-	HYPH
cord-260476-whfyczcj	64	52	I	I	NNP
cord-260476-whfyczcj	64	53	pathway	pathway	VBP
cord-260476-whfyczcj	64	54	[	[	-LRB-
cord-260476-whfyczcj	64	55	39	39	CD
cord-260476-whfyczcj	64	56	]	]	-RRB-
cord-260476-whfyczcj	64	57	.	.	.
cord-260476-whfyczcj	65	1	Moreover	moreover	RB
cord-260476-whfyczcj	65	2	,	,	,
cord-260476-whfyczcj	65	3	this	this	DT
cord-260476-whfyczcj	65	4	study	study	NN
cord-260476-whfyczcj	65	5	showed	show	VBD
cord-260476-whfyczcj	65	6	that	that	IN
cord-260476-whfyczcj	65	7	treatment	treatment	NN
cord-260476-whfyczcj	65	8	with	with	IN
cord-260476-whfyczcj	65	9	DUB	DUB	NNP
cord-260476-whfyczcj	65	10	inhibitors	inhibitor	NNS
cord-260476-whfyczcj	65	11	targeting	target	VBG
cord-260476-whfyczcj	65	12	USP47	USP47	NNP
cord-260476-whfyczcj	65	13	causes	cause	VBZ
cord-260476-whfyczcj	65	14	a	a	DT
cord-260476-whfyczcj	65	15	general	general	JJ
cord-260476-whfyczcj	65	16	Gag	Gag	NNP
cord-260476-whfyczcj	65	17	processing	processing	NN
cord-260476-whfyczcj	65	18	defect	defect	NN
cord-260476-whfyczcj	65	19	,	,	,
cord-260476-whfyczcj	65	20	indicating	indicate	VBG
cord-260476-whfyczcj	65	21	that	that	IN
cord-260476-whfyczcj	65	22	USP47	USP47	NNP
cord-260476-whfyczcj	65	23	interacts	interact	VBZ
cord-260476-whfyczcj	65	24	with	with	IN
cord-260476-whfyczcj	65	25	Gag	Gag	NNP
cord-260476-whfyczcj	65	26	and	and	CC
cord-260476-whfyczcj	65	27	prevents	prevent	VBZ
cord-260476-whfyczcj	65	28	its	-PRON-	PRP$
cord-260476-whfyczcj	65	29	entry	entry	NN
cord-260476-whfyczcj	65	30	into	into	IN
cord-260476-whfyczcj	65	31	the	the	DT
cord-260476-whfyczcj	65	32	UPS	up	NNS
cord-260476-whfyczcj	65	33	.	.	.
cord-260476-whfyczcj	66	1	Similarly	similarly	RB
cord-260476-whfyczcj	66	2	,	,	,
cord-260476-whfyczcj	66	3	proteasome	proteasome	NN
cord-260476-whfyczcj	66	4	inhibitors	inhibitor	NNS
cord-260476-whfyczcj	66	5	have	have	VBP
cord-260476-whfyczcj	66	6	been	be	VBN
cord-260476-whfyczcj	66	7	shown	show	VBN
cord-260476-whfyczcj	66	8	to	to	TO
cord-260476-whfyczcj	66	9	impact	impact	VB
cord-260476-whfyczcj	66	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	66	11	replication	replication	NN
cord-260476-whfyczcj	66	12	by	by	IN
cord-260476-whfyczcj	66	13	reducing	reduce	VBG
cord-260476-whfyczcj	66	14	the	the	DT
cord-260476-whfyczcj	66	15	release	release	NN
cord-260476-whfyczcj	66	16	and	and	CC
cord-260476-whfyczcj	66	17	maturation	maturation	NN
cord-260476-whfyczcj	66	18	of	of	IN
cord-260476-whfyczcj	66	19	infectious	infectious	JJ
cord-260476-whfyczcj	66	20	particles	particle	NNS
cord-260476-whfyczcj	66	21	[	[	-LRB-
cord-260476-whfyczcj	66	22	40	40	CD
cord-260476-whfyczcj	66	23	,	,	,
cord-260476-whfyczcj	66	24	41	41	CD
cord-260476-whfyczcj	66	25	]	]	-RRB-
cord-260476-whfyczcj	66	26	or	or	CC
cord-260476-whfyczcj	66	27	by	by	IN
cord-260476-whfyczcj	66	28	suppressing	suppress	VBG
cord-260476-whfyczcj	66	29	its	-PRON-	PRP$
cord-260476-whfyczcj	66	30	transcription	transcription	NN
cord-260476-whfyczcj	66	31	[	[	-LRB-
cord-260476-whfyczcj	66	32	42	42	CD
cord-260476-whfyczcj	66	33	]	]	-RRB-
cord-260476-whfyczcj	66	34	.	.	.
cord-260476-whfyczcj	67	1	Taken	take	VBN
cord-260476-whfyczcj	67	2	together	together	RB
cord-260476-whfyczcj	67	3	,	,	,
cord-260476-whfyczcj	67	4	these	these	DT
cord-260476-whfyczcj	67	5	studies	study	NNS
cord-260476-whfyczcj	67	6	suggest	suggest	VBP
cord-260476-whfyczcj	67	7	a	a	DT
cord-260476-whfyczcj	67	8	potential	potential	JJ
cord-260476-whfyczcj	67	9	antiretroviral	antiretroviral	JJ
cord-260476-whfyczcj	67	10	activity	activity	NN
cord-260476-whfyczcj	67	11	of	of	IN
cord-260476-whfyczcj	67	12	DUB	dub	NN
cord-260476-whfyczcj	67	13	and	and	CC
cord-260476-whfyczcj	67	14	proteasome	proteasome	NN
cord-260476-whfyczcj	67	15	inhibitors	inhibitor	NNS
cord-260476-whfyczcj	67	16	.	.	.
cord-260476-whfyczcj	68	1	The	the	DT
cord-260476-whfyczcj	68	2	importance	importance	NN
cord-260476-whfyczcj	68	3	of	of	IN
cord-260476-whfyczcj	68	4	the	the	DT
cord-260476-whfyczcj	68	5	UPS	up	NNS
cord-260476-whfyczcj	68	6	in	in	IN
cord-260476-whfyczcj	68	7	antiviral	antiviral	JJ
cord-260476-whfyczcj	68	8	restriction	restriction	NN
cord-260476-whfyczcj	68	9	will	will	MD
cord-260476-whfyczcj	68	10	be	be	VB
cord-260476-whfyczcj	68	11	discussed	discuss	VBN
cord-260476-whfyczcj	68	12	here	here	RB
cord-260476-whfyczcj	68	13	using	use	VBG
cord-260476-whfyczcj	68	14	HIV	HIV	NNP
cord-260476-whfyczcj	68	15	as	as	IN
cord-260476-whfyczcj	68	16	an	an	DT
cord-260476-whfyczcj	68	17	example	example	NN
cord-260476-whfyczcj	68	18	.	.	.
cord-260476-whfyczcj	69	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	69	2	and	and	CC
cord-260476-whfyczcj	69	3	2	2	CD
cord-260476-whfyczcj	69	4	are	be	VBP
cord-260476-whfyczcj	69	5	retroviruses	retrovirus	NNS
cord-260476-whfyczcj	69	6	of	of	IN
cord-260476-whfyczcj	69	7	the	the	DT
cord-260476-whfyczcj	69	8	genus	genus	JJ
cord-260476-whfyczcj	69	9	Lentivirus	Lentivirus	NNP
cord-260476-whfyczcj	69	10	.	.	.
cord-260476-whfyczcj	70	1	Their	-PRON-	PRP$
cord-260476-whfyczcj	70	2	genome	genome	NN
cord-260476-whfyczcj	70	3	is	be	VBZ
cord-260476-whfyczcj	70	4	composed	compose	VBN
cord-260476-whfyczcj	70	5	of	of	IN
cord-260476-whfyczcj	70	6	two	two	CD
cord-260476-whfyczcj	70	7	(	(	-LRB-
cord-260476-whfyczcj	70	8	+	+	CC
cord-260476-whfyczcj	70	9	)	)	-RRB-
cord-260476-whfyczcj	70	10	single	single	JJ
cord-260476-whfyczcj	70	11	stranded	strand	VBN
cord-260476-whfyczcj	70	12	RNAs	rna	NNS
cord-260476-whfyczcj	70	13	encoding	encode	VBG
cord-260476-whfyczcj	70	14	the	the	DT
cord-260476-whfyczcj	70	15	Gag	Gag	NNP
cord-260476-whfyczcj	70	16	,	,	,
cord-260476-whfyczcj	70	17	Pol	Pol	NNP
cord-260476-whfyczcj	70	18	and	and	CC
cord-260476-whfyczcj	70	19	Env	Env	NNP
cord-260476-whfyczcj	70	20	polyproteins	polyprotein	NNS
cord-260476-whfyczcj	70	21	,	,	,
cord-260476-whfyczcj	70	22	which	which	WDT
cord-260476-whfyczcj	70	23	correspond	correspond	VBP
cord-260476-whfyczcj	70	24	to	to	IN
cord-260476-whfyczcj	70	25	the	the	DT
cord-260476-whfyczcj	70	26	structural	structural	JJ
cord-260476-whfyczcj	70	27	(	(	-LRB-
cord-260476-whfyczcj	70	28	matrix	matrix	NN
cord-260476-whfyczcj	70	29	,	,	,
cord-260476-whfyczcj	70	30	capsid	capsid	NN
cord-260476-whfyczcj	70	31	,	,	,
cord-260476-whfyczcj	70	32	nucleocapsid	nucleocapsid	NN
cord-260476-whfyczcj	70	33	and	and	CC
cord-260476-whfyczcj	70	34	p6	p6	NNP
cord-260476-whfyczcj	70	35	)	)	-RRB-
cord-260476-whfyczcj	70	36	,	,	,
cord-260476-whfyczcj	70	37	enzymatic	enzymatic	JJ
cord-260476-whfyczcj	70	38	(	(	-LRB-
cord-260476-whfyczcj	70	39	protease	protease	NN
cord-260476-whfyczcj	70	40	,	,	,
cord-260476-whfyczcj	70	41	reverse	reverse	NN
cord-260476-whfyczcj	70	42	-	-	HYPH
cord-260476-whfyczcj	70	43	transcriptase	transcriptase	NN
cord-260476-whfyczcj	70	44	and	and	CC
cord-260476-whfyczcj	70	45	integrase	integrase	NN
cord-260476-whfyczcj	70	46	)	)	-RRB-
cord-260476-whfyczcj	70	47	and	and	CC
cord-260476-whfyczcj	70	48	envelope	envelope	NN
cord-260476-whfyczcj	70	49	(	(	-LRB-
cord-260476-whfyczcj	70	50	transmembrane	transmembrane	NN
cord-260476-whfyczcj	70	51	and	and	CC
cord-260476-whfyczcj	70	52	surface	surface	NN
cord-260476-whfyczcj	70	53	)	)	-RRB-
cord-260476-whfyczcj	70	54	viral	viral	JJ
cord-260476-whfyczcj	70	55	proteins	protein	NNS
cord-260476-whfyczcj	70	56	.	.	.
cord-260476-whfyczcj	71	1	In	in	IN
cord-260476-whfyczcj	71	2	addition	addition	NN
cord-260476-whfyczcj	71	3	,	,	,
cord-260476-whfyczcj	71	4	the	the	DT
cord-260476-whfyczcj	71	5	genome	genome	NN
cord-260476-whfyczcj	71	6	of	of	IN
cord-260476-whfyczcj	71	7	these	these	DT
cord-260476-whfyczcj	71	8	two	two	CD
cord-260476-whfyczcj	71	9	viruses	virus	NNS
cord-260476-whfyczcj	71	10	express	express	VBP
cord-260476-whfyczcj	71	11	two	two	CD
cord-260476-whfyczcj	71	12	regulatory	regulatory	JJ
cord-260476-whfyczcj	71	13	(	(	-LRB-
cord-260476-whfyczcj	71	14	Tat	Tat	NNP
cord-260476-whfyczcj	71	15	and	and	CC
cord-260476-whfyczcj	71	16	Rev	Rev	NNP
cord-260476-whfyczcj	71	17	)	)	-RRB-
cord-260476-whfyczcj	71	18	and	and	CC
cord-260476-whfyczcj	71	19	four	four	CD
cord-260476-whfyczcj	71	20	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	72	1	(	(	-LRB-
cord-260476-whfyczcj	72	2	Nef	Nef	NNP
cord-260476-whfyczcj	72	3	,	,	,
cord-260476-whfyczcj	72	4	Vpu	Vpu	NNP
cord-260476-whfyczcj	72	5	/	/	SYM
cord-260476-whfyczcj	72	6	Vpx	Vpx	NNP
cord-260476-whfyczcj	72	7	,	,	,
cord-260476-whfyczcj	72	8	Vpr	Vpr	NNP
cord-260476-whfyczcj	72	9	and	and	CC
cord-260476-whfyczcj	72	10	Vif	Vif	NNP
cord-260476-whfyczcj	72	11	)	)	-RRB-
cord-260476-whfyczcj	72	12	proteins	protein	NNS
cord-260476-whfyczcj	72	13	,	,	,
cord-260476-whfyczcj	72	14	which	which	WDT
cord-260476-whfyczcj	72	15	regulate	regulate	VBP
cord-260476-whfyczcj	72	16	several	several	JJ
cord-260476-whfyczcj	72	17	steps	step	NNS
cord-260476-whfyczcj	72	18	in	in	IN
cord-260476-whfyczcj	72	19	the	the	DT
cord-260476-whfyczcj	72	20	viral	viral	JJ
cord-260476-whfyczcj	72	21	life	life	NN
cord-260476-whfyczcj	72	22	cycle	cycle	NN
cord-260476-whfyczcj	72	23	[	[	-LRB-
cord-260476-whfyczcj	72	24	43	43	CD
cord-260476-whfyczcj	72	25	,	,	,
cord-260476-whfyczcj	72	26	44	44	CD
cord-260476-whfyczcj	72	27	]	]	-RRB-
cord-260476-whfyczcj	72	28	.	.	.
cord-260476-whfyczcj	73	1	The	the	DT
cord-260476-whfyczcj	73	2	main	main	JJ
cord-260476-whfyczcj	73	3	difference	difference	NN
cord-260476-whfyczcj	73	4	between	between	IN
cord-260476-whfyczcj	73	5	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	73	6	and	and	CC
cord-260476-whfyczcj	73	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	73	8	is	be	VBZ
cord-260476-whfyczcj	73	9	the	the	DT
cord-260476-whfyczcj	73	10	lack	lack	NN
cord-260476-whfyczcj	73	11	of	of	IN
cord-260476-whfyczcj	73	12	the	the	DT
cord-260476-whfyczcj	73	13	Vpu	Vpu	NNP
cord-260476-whfyczcj	73	14	protein	protein	NN
cord-260476-whfyczcj	73	15	in	in	IN
cord-260476-whfyczcj	73	16	the	the	DT
cord-260476-whfyczcj	73	17	former	former	JJ
cord-260476-whfyczcj	73	18	,	,	,
cord-260476-whfyczcj	73	19	which	which	WDT
cord-260476-whfyczcj	73	20	is	be	VBZ
cord-260476-whfyczcj	73	21	replaced	replace	VBN
cord-260476-whfyczcj	73	22	by	by	IN
cord-260476-whfyczcj	73	23	Vpx	Vpx	NNP
cord-260476-whfyczcj	73	24	[	[	-LRB-
cord-260476-whfyczcj	73	25	45	45	CD
cord-260476-whfyczcj	73	26	]	]	-RRB-
cord-260476-whfyczcj	73	27	.	.	.
cord-260476-whfyczcj	74	1	Following	follow	VBG
cord-260476-whfyczcj	74	2	viral	viral	JJ
cord-260476-whfyczcj	74	3	attachment	attachment	NN
cord-260476-whfyczcj	74	4	and	and	CC
cord-260476-whfyczcj	74	5	entry	entry	NN
cord-260476-whfyczcj	74	6	into	into	IN
cord-260476-whfyczcj	74	7	the	the	DT
cord-260476-whfyczcj	74	8	target	target	NN
cord-260476-whfyczcj	74	9	cell	cell	NN
cord-260476-whfyczcj	74	10	,	,	,
cord-260476-whfyczcj	74	11	the	the	DT
cord-260476-whfyczcj	74	12	dimeric	dimeric	JJ
cord-260476-whfyczcj	74	13	viral	viral	JJ
cord-260476-whfyczcj	74	14	genomic	genomic	NNP
cord-260476-whfyczcj	74	15	RNA	RNA	NNP
cord-260476-whfyczcj	74	16	is	be	VBZ
cord-260476-whfyczcj	74	17	partially	partially	RB
cord-260476-whfyczcj	74	18	uncoated	uncoate	VBN
cord-260476-whfyczcj	74	19	and	and	CC
cord-260476-whfyczcj	74	20	transported	transport	VBN
cord-260476-whfyczcj	74	21	to	to	IN
cord-260476-whfyczcj	74	22	the	the	DT
cord-260476-whfyczcj	74	23	cell	cell	NN
cord-260476-whfyczcj	74	24	nucleus	nucleus	NN
cord-260476-whfyczcj	74	25	.	.	.
cord-260476-whfyczcj	75	1	Concomitantly	concomitantly	RB
cord-260476-whfyczcj	75	2	,	,	,
cord-260476-whfyczcj	75	3	reverse	reverse	VB
cord-260476-whfyczcj	75	4	transcription	transcription	NN
cord-260476-whfyczcj	75	5	of	of	IN
cord-260476-whfyczcj	75	6	the	the	DT
cord-260476-whfyczcj	75	7	viral	viral	JJ
cord-260476-whfyczcj	75	8	genomic	genomic	JJ
cord-260476-whfyczcj	75	9	RNA	RNA	NNP
cord-260476-whfyczcj	75	10	takes	take	VBZ
cord-260476-whfyczcj	75	11	place	place	NN
cord-260476-whfyczcj	75	12	to	to	TO
cord-260476-whfyczcj	75	13	form	form	VB
cord-260476-whfyczcj	75	14	the	the	DT
cord-260476-whfyczcj	75	15	pre	pre	JJ
cord-260476-whfyczcj	75	16	-	-	JJ
cord-260476-whfyczcj	75	17	proviral	proviral	JJ
cord-260476-whfyczcj	75	18	DNA	dna	NN
cord-260476-whfyczcj	75	19	,	,	,
cord-260476-whfyczcj	75	20	which	which	WDT
cord-260476-whfyczcj	75	21	is	be	VBZ
cord-260476-whfyczcj	75	22	then	then	RB
cord-260476-whfyczcj	75	23	integrated	integrate	VBN
cord-260476-whfyczcj	75	24	into	into	IN
cord-260476-whfyczcj	75	25	the	the	DT
cord-260476-whfyczcj	75	26	cellular	cellular	JJ
cord-260476-whfyczcj	75	27	genome	genome	NN
cord-260476-whfyczcj	75	28	.	.	.
cord-260476-whfyczcj	76	1	The	the	DT
cord-260476-whfyczcj	76	2	integrated	integrated	JJ
cord-260476-whfyczcj	76	3	provirus	provirus	NNP
cord-260476-whfyczcj	76	4	mediates	mediate	VBZ
cord-260476-whfyczcj	76	5	the	the	DT
cord-260476-whfyczcj	76	6	synthesis	synthesis	NN
cord-260476-whfyczcj	76	7	of	of	IN
cord-260476-whfyczcj	76	8	new	new	JJ
cord-260476-whfyczcj	76	9	full	full	JJ
cord-260476-whfyczcj	76	10	-	-	HYPH
cord-260476-whfyczcj	76	11	length	length	NN
cord-260476-whfyczcj	76	12	viral	viral	JJ
cord-260476-whfyczcj	76	13	RNA	RNA	NNP
cord-260476-whfyczcj	76	14	(	(	-LRB-
cord-260476-whfyczcj	76	15	or	or	CC
cord-260476-whfyczcj	76	16	unspliced	unspliced	NNP
cord-260476-whfyczcj	76	17	RNA	RNA	NNP
cord-260476-whfyczcj	76	18	)	)	-RRB-
cord-260476-whfyczcj	76	19	,	,	,
cord-260476-whfyczcj	76	20	which	which	WDT
cord-260476-whfyczcj	76	21	will	will	MD
cord-260476-whfyczcj	76	22	be	be	VB
cord-260476-whfyczcj	76	23	used	use	VBN
cord-260476-whfyczcj	76	24	as	as	IN
cord-260476-whfyczcj	76	25	genomic	genomic	JJ
cord-260476-whfyczcj	76	26	RNA	RNA	NNP
cord-260476-whfyczcj	76	27	encapsidated	encapsidate	VBN
cord-260476-whfyczcj	76	28	into	into	IN
cord-260476-whfyczcj	76	29	viral	viral	JJ
cord-260476-whfyczcj	76	30	particles	particle	NNS
cord-260476-whfyczcj	76	31	and	and	CC
cord-260476-whfyczcj	76	32	as	as	IN
cord-260476-whfyczcj	76	33	mRNA	mrna	NN
cord-260476-whfyczcj	76	34	for	for	IN
cord-260476-whfyczcj	76	35	structural	structural	JJ
cord-260476-whfyczcj	76	36	and	and	CC
cord-260476-whfyczcj	76	37	enzymatic	enzymatic	JJ
cord-260476-whfyczcj	76	38	proteins	protein	NNS
cord-260476-whfyczcj	76	39	and	and	CC
cord-260476-whfyczcj	76	40	mono	mono	NN
cord-260476-whfyczcj	76	41	-	-	HYPH
cord-260476-whfyczcj	76	42	and	and	CC
cord-260476-whfyczcj	76	43	multi	multi	JJ
cord-260476-whfyczcj	76	44	-	-	JJ
cord-260476-whfyczcj	76	45	spliced	spliced	JJ
cord-260476-whfyczcj	76	46	viral	viral	JJ
cord-260476-whfyczcj	76	47	mRNAs	mrna	NNS
cord-260476-whfyczcj	76	48	,	,	,
cord-260476-whfyczcj	76	49	which	which	WDT
cord-260476-whfyczcj	76	50	encode	encode	VBP
cord-260476-whfyczcj	76	51	the	the	DT
cord-260476-whfyczcj	76	52	viral	viral	JJ
cord-260476-whfyczcj	76	53	envelope	envelope	NN
cord-260476-whfyczcj	76	54	and	and	CC
cord-260476-whfyczcj	76	55	the	the	DT
cord-260476-whfyczcj	76	56	regulatory	regulatory	JJ
cord-260476-whfyczcj	76	57	and	and	CC
cord-260476-whfyczcj	76	58	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	76	59	proteins	protein	NNS
cord-260476-whfyczcj	76	60	in	in	IN
cord-260476-whfyczcj	76	61	the	the	DT
cord-260476-whfyczcj	76	62	infected	infected	JJ
cord-260476-whfyczcj	76	63	cell	cell	NN
cord-260476-whfyczcj	76	64	.	.	.
cord-260476-whfyczcj	77	1	Finally	finally	RB
cord-260476-whfyczcj	77	2	,	,	,
cord-260476-whfyczcj	77	3	the	the	DT
cord-260476-whfyczcj	77	4	components	component	NNS
cord-260476-whfyczcj	77	5	of	of	IN
cord-260476-whfyczcj	77	6	the	the	DT
cord-260476-whfyczcj	77	7	viral	viral	JJ
cord-260476-whfyczcj	77	8	particle	particle	NN
cord-260476-whfyczcj	77	9	assemble	assemble	VB
cord-260476-whfyczcj	77	10	at	at	IN
cord-260476-whfyczcj	77	11	the	the	DT
cord-260476-whfyczcj	77	12	plasma	plasma	NN
cord-260476-whfyczcj	77	13	membrane	membrane	NN
cord-260476-whfyczcj	77	14	,	,	,
cord-260476-whfyczcj	77	15	where	where	WRB
cord-260476-whfyczcj	77	16	new	new	JJ
cord-260476-whfyczcj	77	17	viral	viral	JJ
cord-260476-whfyczcj	77	18	particles	particle	NNS
cord-260476-whfyczcj	77	19	bud	bud	NN
cord-260476-whfyczcj	77	20	,	,	,
cord-260476-whfyczcj	77	21	maturate	maturate	NNP
cord-260476-whfyczcj	77	22	and	and	CC
cord-260476-whfyczcj	77	23	disseminate	disseminate	VB
cord-260476-whfyczcj	77	24	to	to	IN
cord-260476-whfyczcj	77	25	other	other	JJ
cord-260476-whfyczcj	77	26	host	host	NN
cord-260476-whfyczcj	77	27	cells	cell	NNS
cord-260476-whfyczcj	77	28	in	in	IN
cord-260476-whfyczcj	77	29	the	the	DT
cord-260476-whfyczcj	77	30	infected	infected	JJ
cord-260476-whfyczcj	77	31	organism	organism	NN
cord-260476-whfyczcj	77	32	(	(	-LRB-
cord-260476-whfyczcj	77	33	Figure	figure	NN
cord-260476-whfyczcj	77	34	2	2	CD
cord-260476-whfyczcj	77	35	)	)	-RRB-
cord-260476-whfyczcj	77	36	[	[	-LRB-
cord-260476-whfyczcj	77	37	43	43	CD
cord-260476-whfyczcj	77	38	,	,	,
cord-260476-whfyczcj	77	39	44	44	CD
cord-260476-whfyczcj	77	40	,	,	,
cord-260476-whfyczcj	77	41	[	[	-LRB-
cord-260476-whfyczcj	77	42	46	46	CD
cord-260476-whfyczcj	77	43	]	]	-RRB-
cord-260476-whfyczcj	77	44	[	[	-LRB-
cord-260476-whfyczcj	77	45	47	47	CD
cord-260476-whfyczcj	77	46	]	]	-RRB-
cord-260476-whfyczcj	77	47	[	[	-LRB-
cord-260476-whfyczcj	77	48	48	48	CD
cord-260476-whfyczcj	77	49	]	]	-RRB-
cord-260476-whfyczcj	77	50	[	[	-LRB-
cord-260476-whfyczcj	77	51	49	49	CD
cord-260476-whfyczcj	77	52	]	]	-RRB-
cord-260476-whfyczcj	77	53	.	.	.
cord-260476-whfyczcj	78	1	During	during	IN
cord-260476-whfyczcj	78	2	its	-PRON-	PRP$
cord-260476-whfyczcj	78	3	life	life	NN
cord-260476-whfyczcj	78	4	cycle	cycle	NN
cord-260476-whfyczcj	78	5	,	,	,
cord-260476-whfyczcj	78	6	HIV	HIV	NNP
cord-260476-whfyczcj	78	7	is	be	VBZ
cord-260476-whfyczcj	78	8	subjected	subject	VBN
cord-260476-whfyczcj	78	9	to	to	IN
cord-260476-whfyczcj	78	10	different	different	JJ
cord-260476-whfyczcj	78	11	cellular	cellular	JJ
cord-260476-whfyczcj	78	12	restriction	restriction	NN
cord-260476-whfyczcj	78	13	factors	factor	NNS
cord-260476-whfyczcj	78	14	(	(	-LRB-
cord-260476-whfyczcj	78	15	Figure	figure	NN
cord-260476-whfyczcj	78	16	2	2	CD
cord-260476-whfyczcj	78	17	)	)	-RRB-
cord-260476-whfyczcj	78	18	,	,	,
cord-260476-whfyczcj	78	19	the	the	DT
cord-260476-whfyczcj	78	20	first	first	JJ
cord-260476-whfyczcj	78	21	line	line	NN
cord-260476-whfyczcj	78	22	of	of	IN
cord-260476-whfyczcj	78	23	defense	defense	NN
cord-260476-whfyczcj	78	24	of	of	IN
cord-260476-whfyczcj	78	25	cellular	cellular	JJ
cord-260476-whfyczcj	78	26	immunity	immunity	NN
cord-260476-whfyczcj	78	27	.	.	.
cord-260476-whfyczcj	79	1	The	the	DT
cord-260476-whfyczcj	79	2	newly	newly	RB
cord-260476-whfyczcj	79	3	discovered	discover	VBN
cord-260476-whfyczcj	79	4	SERINC3	SERINC3	NNS
cord-260476-whfyczcj	80	1	(	(	-LRB-
cord-260476-whfyczcj	80	2	SERine	SERine	NNP
cord-260476-whfyczcj	80	3	INCorporator	INCorporator	NNP
cord-260476-whfyczcj	80	4	3	3	CD
cord-260476-whfyczcj	80	5	)	)	-RRB-
cord-260476-whfyczcj	80	6	and	and	CC
cord-260476-whfyczcj	80	7	SERINC5	serinc5	RB
cord-260476-whfyczcj	81	1	proteins	protein	NNS
cord-260476-whfyczcj	81	2	target	target	VBP
cord-260476-whfyczcj	81	3	the	the	DT
cord-260476-whfyczcj	81	4	very	very	JJ
cord-260476-whfyczcj	81	5	beginning	beginning	NN
cord-260476-whfyczcj	81	6	of	of	IN
cord-260476-whfyczcj	81	7	the	the	DT
cord-260476-whfyczcj	81	8	viral	viral	JJ
cord-260476-whfyczcj	81	9	life	life	NN
cord-260476-whfyczcj	81	10	cycle	cycle	NN
cord-260476-whfyczcj	81	11	by	by	IN
cord-260476-whfyczcj	81	12	inhibiting	inhibit	VBG
cord-260476-whfyczcj	81	13	correct	correct	JJ
cord-260476-whfyczcj	81	14	fusion	fusion	NN
cord-260476-whfyczcj	81	15	of	of	IN
cord-260476-whfyczcj	81	16	the	the	DT
cord-260476-whfyczcj	81	17	viral	viral	JJ
cord-260476-whfyczcj	81	18	envelope	envelope	NN
cord-260476-whfyczcj	81	19	with	with	IN
cord-260476-whfyczcj	81	20	the	the	DT
cord-260476-whfyczcj	81	21	plasma	plasma	NN
cord-260476-whfyczcj	81	22	membrane	membrane	NN
cord-260476-whfyczcj	81	23	,	,	,
cord-260476-whfyczcj	81	24	thereby	thereby	RB
cord-260476-whfyczcj	81	25	preventing	prevent	VBG
cord-260476-whfyczcj	81	26	the	the	DT
cord-260476-whfyczcj	81	27	virus	virus	NN
cord-260476-whfyczcj	81	28	from	from	IN
cord-260476-whfyczcj	81	29	entering	enter	VBG
cord-260476-whfyczcj	81	30	into	into	IN
cord-260476-whfyczcj	81	31	a	a	DT
cord-260476-whfyczcj	81	32	new	new	JJ
cord-260476-whfyczcj	81	33	host	host	NN
cord-260476-whfyczcj	81	34	cell	cell	NN
cord-260476-whfyczcj	81	35	[	[	-LRB-
cord-260476-whfyczcj	81	36	50	50	CD
cord-260476-whfyczcj	81	37	,	,	,
cord-260476-whfyczcj	81	38	51	51	CD
cord-260476-whfyczcj	81	39	]	]	-RRB-
cord-260476-whfyczcj	81	40	.	.	.
cord-260476-whfyczcj	82	1	IFITM	IFITM	NNP
cord-260476-whfyczcj	83	1	(	(	-LRB-
cord-260476-whfyczcj	83	2	InterFeron	InterFeron	NNP
cord-260476-whfyczcj	83	3	-	-	HYPH
cord-260476-whfyczcj	83	4	Induced	induce	VBN
cord-260476-whfyczcj	83	5	TransMembrane	TransMembrane	NNP
cord-260476-whfyczcj	83	6	)	)	-RRB-
cord-260476-whfyczcj	83	7	proteins	protein	VBZ
cord-260476-whfyczcj	83	8	1	1	CD
cord-260476-whfyczcj	83	9	,	,	,
cord-260476-whfyczcj	83	10	2	2	CD
cord-260476-whfyczcj	83	11	and	and	CC
cord-260476-whfyczcj	83	12	3	3	CD
cord-260476-whfyczcj	83	13	also	also	RB
cord-260476-whfyczcj	83	14	target	target	VB
cord-260476-whfyczcj	83	15	the	the	DT
cord-260476-whfyczcj	83	16	viral	viral	JJ
cord-260476-whfyczcj	83	17	entry	entry	NN
cord-260476-whfyczcj	83	18	into	into	IN
cord-260476-whfyczcj	83	19	the	the	DT
cord-260476-whfyczcj	83	20	cell	cell	NN
cord-260476-whfyczcj	83	21	by	by	IN
cord-260476-whfyczcj	83	22	inhibiting	inhibit	VBG
cord-260476-whfyczcj	83	23	viral	viral	JJ
cord-260476-whfyczcj	83	24	fusion	fusion	NN
cord-260476-whfyczcj	83	25	with	with	IN
cord-260476-whfyczcj	83	26	target	target	NN
cord-260476-whfyczcj	83	27	cells	cell	NNS
cord-260476-whfyczcj	83	28	.	.	.
cord-260476-whfyczcj	84	1	The	the	DT
cord-260476-whfyczcj	84	2	exact	exact	JJ
cord-260476-whfyczcj	84	3	mechanism	mechanism	NN
cord-260476-whfyczcj	84	4	of	of	IN
cord-260476-whfyczcj	84	5	restriction	restriction	NN
cord-260476-whfyczcj	84	6	is	be	VBZ
cord-260476-whfyczcj	84	7	yet	yet	RB
cord-260476-whfyczcj	84	8	a	a	DT
cord-260476-whfyczcj	84	9	matter	matter	NN
cord-260476-whfyczcj	84	10	of	of	IN
cord-260476-whfyczcj	84	11	debate	debate	NN
cord-260476-whfyczcj	84	12	,	,	,
cord-260476-whfyczcj	84	13	as	as	RB
cord-260476-whfyczcj	84	14	well	well	RB
cord-260476-whfyczcj	84	15	as	as	IN
cord-260476-whfyczcj	84	16	whether	whether	IN
cord-260476-whfyczcj	84	17	IFITM	IFITM	NNP
cord-260476-whfyczcj	84	18	incorporation	incorporation	NN
cord-260476-whfyczcj	84	19	in	in	IN
cord-260476-whfyczcj	84	20	virions	virion	NNS
cord-260476-whfyczcj	84	21	or	or	CC
cord-260476-whfyczcj	84	22	its	-PRON-	PRP$
cord-260476-whfyczcj	84	23	expression	expression	NN
cord-260476-whfyczcj	84	24	in	in	IN
cord-260476-whfyczcj	84	25	target	target	NN
cord-260476-whfyczcj	84	26	cells	cell	NNS
cord-260476-whfyczcj	84	27	is	be	VBZ
cord-260476-whfyczcj	84	28	responsible	responsible	JJ
cord-260476-whfyczcj	84	29	for	for	IN
cord-260476-whfyczcj	84	30	the	the	DT
cord-260476-whfyczcj	84	31	antiviral	antiviral	JJ
cord-260476-whfyczcj	84	32	effect	effect	NN
cord-260476-whfyczcj	84	33	.	.	.
cord-260476-whfyczcj	85	1	IFITM	ifitm	NN
cord-260476-whfyczcj	85	2	proteins	protein	NNS
cord-260476-whfyczcj	85	3	might	may	MD
cord-260476-whfyczcj	85	4	act	act	VB
cord-260476-whfyczcj	85	5	on	on	IN
cord-260476-whfyczcj	85	6	Env	Env	NNP
cord-260476-whfyczcj	85	7	to	to	TO
cord-260476-whfyczcj	85	8	inhibit	inhibit	VB
cord-260476-whfyczcj	85	9	its	-PRON-	PRP$
cord-260476-whfyczcj	85	10	functions	function	NNS
cord-260476-whfyczcj	85	11	in	in	IN
cord-260476-whfyczcj	85	12	viral	viral	JJ
cord-260476-whfyczcj	85	13	fusion	fusion	NN
cord-260476-whfyczcj	85	14	and	and	CC
cord-260476-whfyczcj	85	15	it	-PRON-	PRP
cord-260476-whfyczcj	85	16	has	have	VBZ
cord-260476-whfyczcj	85	17	been	be	VBN
cord-260476-whfyczcj	85	18	shown	show	VBN
cord-260476-whfyczcj	85	19	that	that	IN
cord-260476-whfyczcj	85	20	some	some	DT
cord-260476-whfyczcj	85	21	mutations	mutation	NNS
cord-260476-whfyczcj	85	22	in	in	IN
cord-260476-whfyczcj	85	23	the	the	DT
cord-260476-whfyczcj	85	24	Env	Env	NNP
cord-260476-whfyczcj	85	25	protein	protein	NN
cord-260476-whfyczcj	85	26	can	can	MD
cord-260476-whfyczcj	85	27	indeed	indeed	RB
cord-260476-whfyczcj	85	28	confer	confer	VB
cord-260476-whfyczcj	85	29	resistance	resistance	NN
cord-260476-whfyczcj	85	30	to	to	IN
cord-260476-whfyczcj	85	31	IFITM	IFITM	NNP
cord-260476-whfyczcj	85	32	restriction	restriction	NN
cord-260476-whfyczcj	85	33	[	[	-LRB-
cord-260476-whfyczcj	85	34	52	52	CD
cord-260476-whfyczcj	85	35	]	]	-RRB-
cord-260476-whfyczcj	85	36	[	[	-LRB-
cord-260476-whfyczcj	85	37	53	53	CD
cord-260476-whfyczcj	85	38	]	]	-RRB-
cord-260476-whfyczcj	85	39	[	[	-LRB-
cord-260476-whfyczcj	85	40	54	54	CD
cord-260476-whfyczcj	85	41	]	]	-RRB-
cord-260476-whfyczcj	85	42	[	[	-LRB-
cord-260476-whfyczcj	85	43	55	55	CD
cord-260476-whfyczcj	85	44	]	]	-RRB-
cord-260476-whfyczcj	85	45	[	[	-LRB-
cord-260476-whfyczcj	85	46	56	56	CD
cord-260476-whfyczcj	85	47	]	]	-RRB-
cord-260476-whfyczcj	85	48	[	[	-LRB-
cord-260476-whfyczcj	85	49	57	57	CD
cord-260476-whfyczcj	85	50	]	]	-RRB-
cord-260476-whfyczcj	85	51	.	.	.
cord-260476-whfyczcj	86	1	Once	once	IN
cord-260476-whfyczcj	86	2	the	the	DT
cord-260476-whfyczcj	86	3	virus	virus	NN
cord-260476-whfyczcj	86	4	has	have	VBZ
cord-260476-whfyczcj	86	5	entered	enter	VBN
cord-260476-whfyczcj	86	6	the	the	DT
cord-260476-whfyczcj	86	7	cell	cell	NN
cord-260476-whfyczcj	86	8	,	,	,
cord-260476-whfyczcj	86	9	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	86	10	(	(	-LRB-
cord-260476-whfyczcj	86	11	TRIpartite	TRIpartite	NNP
cord-260476-whfyczcj	86	12	Motif	motif	NN
cord-260476-whfyczcj	86	13	-	-	HYPH
cord-260476-whfyczcj	86	14	containing	contain	VBG
cord-260476-whfyczcj	86	15	protein	protein	NN
cord-260476-whfyczcj	86	16	5α	5α	CD
cord-260476-whfyczcj	86	17	)	)	-RRB-
cord-260476-whfyczcj	86	18	can	can	MD
cord-260476-whfyczcj	86	19	inhibit	inhibit	VB
cord-260476-whfyczcj	86	20	the	the	DT
cord-260476-whfyczcj	86	21	early	early	JJ
cord-260476-whfyczcj	86	22	steps	step	NNS
cord-260476-whfyczcj	86	23	of	of	IN
cord-260476-whfyczcj	86	24	the	the	DT
cord-260476-whfyczcj	86	25	viral	viral	JJ
cord-260476-whfyczcj	86	26	life	life	NN
cord-260476-whfyczcj	86	27	cycle	cycle	NN
cord-260476-whfyczcj	86	28	in	in	IN
cord-260476-whfyczcj	86	29	a	a	DT
cord-260476-whfyczcj	86	30	species	species	NN
cord-260476-whfyczcj	86	31	-	-	HYPH
cord-260476-whfyczcj	86	32	specific	specific	JJ
cord-260476-whfyczcj	86	33	manner	manner	NN
cord-260476-whfyczcj	86	34	by	by	IN
cord-260476-whfyczcj	86	35	accelerating	accelerate	VBG
cord-260476-whfyczcj	86	36	viral	viral	JJ
cord-260476-whfyczcj	86	37	uncoating	uncoate	VBG
cord-260476-whfyczcj	86	38	[	[	-LRB-
cord-260476-whfyczcj	86	39	58	58	CD
cord-260476-whfyczcj	86	40	]	]	-RRB-
cord-260476-whfyczcj	86	41	[	[	-LRB-
cord-260476-whfyczcj	86	42	59	59	CD
cord-260476-whfyczcj	86	43	]	]	-RRB-
cord-260476-whfyczcj	86	44	[	[	-LRB-
cord-260476-whfyczcj	86	45	60	60	CD
cord-260476-whfyczcj	86	46	]	]	-RRB-
cord-260476-whfyczcj	86	47	.	.	.
cord-260476-whfyczcj	87	1	The	the	DT
cord-260476-whfyczcj	87	2	viral	viral	JJ
cord-260476-whfyczcj	87	3	capsid	capsid	NN
cord-260476-whfyczcj	87	4	protein	protein	NN
cord-260476-whfyczcj	87	5	also	also	RB
cord-260476-whfyczcj	87	6	seems	seem	VBZ
cord-260476-whfyczcj	87	7	to	to	TO
cord-260476-whfyczcj	87	8	be	be	VB
cord-260476-whfyczcj	87	9	the	the	DT
cord-260476-whfyczcj	87	10	target	target	NN
cord-260476-whfyczcj	87	11	of	of	IN
cord-260476-whfyczcj	87	12	Myxovirus	Myxovirus	NNP
cord-260476-whfyczcj	87	13	resistance	resistance	NN
cord-260476-whfyczcj	87	14	2	2	CD
cord-260476-whfyczcj	87	15	(	(	-LRB-
cord-260476-whfyczcj	87	16	Mx2	Mx2	NNP
cord-260476-whfyczcj	87	17	/	/	SYM
cord-260476-whfyczcj	87	18	B	B	NNP
cord-260476-whfyczcj	87	19	)	)	-RRB-
cord-260476-whfyczcj	87	20	,	,	,
cord-260476-whfyczcj	87	21	a	a	DT
cord-260476-whfyczcj	87	22	restriction	restriction	NN
cord-260476-whfyczcj	87	23	factor	factor	NN
cord-260476-whfyczcj	87	24	that	that	WDT
cord-260476-whfyczcj	87	25	inhibits	inhibit	VBZ
cord-260476-whfyczcj	87	26	nuclear	nuclear	JJ
cord-260476-whfyczcj	87	27	import	import	NN
cord-260476-whfyczcj	87	28	and	and	CC
cord-260476-whfyczcj	87	29	subsequent	subsequent	JJ
cord-260476-whfyczcj	87	30	integration	integration	NN
cord-260476-whfyczcj	87	31	of	of	IN
cord-260476-whfyczcj	87	32	the	the	DT
cord-260476-whfyczcj	87	33	provirus	provirus	NNP
cord-260476-whfyczcj	87	34	through	through	IN
cord-260476-whfyczcj	87	35	an	an	DT
cord-260476-whfyczcj	87	36	unknown	unknown	JJ
cord-260476-whfyczcj	87	37	mechanism	mechanism	NN
cord-260476-whfyczcj	87	38	.	.	.
cord-260476-whfyczcj	88	1	Some	some	DT
cord-260476-whfyczcj	88	2	mutations	mutation	NNS
cord-260476-whfyczcj	88	3	in	in	IN
cord-260476-whfyczcj	88	4	the	the	DT
cord-260476-whfyczcj	88	5	capsid	capsid	NN
cord-260476-whfyczcj	88	6	protein	protein	NN
cord-260476-whfyczcj	88	7	have	have	VBP
cord-260476-whfyczcj	88	8	been	be	VBN
cord-260476-whfyczcj	88	9	shown	show	VBN
cord-260476-whfyczcj	88	10	to	to	TO
cord-260476-whfyczcj	88	11	confer	confer	VB
cord-260476-whfyczcj	88	12	resistance	resistance	NN
cord-260476-whfyczcj	88	13	to	to	IN
cord-260476-whfyczcj	88	14	Mx2	mx2	CD
cord-260476-whfyczcj	88	15	and	and	CC
cord-260476-whfyczcj	88	16	particularly	particularly	RB
cord-260476-whfyczcj	88	17	some	some	DT
cord-260476-whfyczcj	88	18	mutations	mutation	NNS
cord-260476-whfyczcj	88	19	located	locate	VBN
cord-260476-whfyczcj	88	20	at	at	IN
cord-260476-whfyczcj	88	21	the	the	DT
cord-260476-whfyczcj	88	22	site	site	NN
cord-260476-whfyczcj	88	23	of	of	IN
cord-260476-whfyczcj	88	24	interaction	interaction	NN
cord-260476-whfyczcj	88	25	with	with	IN
cord-260476-whfyczcj	88	26	cyclophilin	cyclophilin	NNP
cord-260476-whfyczcj	88	27	A	A	NNP
cord-260476-whfyczcj	88	28	,	,	,
cord-260476-whfyczcj	88	29	an	an	DT
cord-260476-whfyczcj	88	30	important	important	JJ
cord-260476-whfyczcj	88	31	host	host	NN
cord-260476-whfyczcj	88	32	factor	factor	NN
cord-260476-whfyczcj	88	33	for	for	IN
cord-260476-whfyczcj	88	34	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	88	35	infectivity	infectivity	NN
cord-260476-whfyczcj	88	36	[	[	-LRB-
cord-260476-whfyczcj	88	37	61	61	CD
cord-260476-whfyczcj	88	38	]	]	-RRB-
cord-260476-whfyczcj	88	39	[	[	-LRB-
cord-260476-whfyczcj	88	40	62	62	CD
cord-260476-whfyczcj	88	41	]	]	-RRB-
cord-260476-whfyczcj	88	42	[	[	-LRB-
cord-260476-whfyczcj	88	43	63	63	CD
cord-260476-whfyczcj	88	44	]	]	-RRB-
cord-260476-whfyczcj	88	45	[	[	-LRB-
cord-260476-whfyczcj	88	46	64	64	CD
cord-260476-whfyczcj	88	47	]	]	-RRB-
cord-260476-whfyczcj	89	1	[	[	-LRB-
cord-260476-whfyczcj	89	2	65	65	CD
cord-260476-whfyczcj	89	3	]	]	-RRB-
cord-260476-whfyczcj	89	4	[	[	-LRB-
cord-260476-whfyczcj	89	5	66	66	CD
cord-260476-whfyczcj	89	6	]	]	-RRB-
cord-260476-whfyczcj	89	7	.	.	.
cord-260476-whfyczcj	90	1	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	91	1	(	(	-LRB-
cord-260476-whfyczcj	91	2	Sterile	sterile	JJ
cord-260476-whfyczcj	91	3	Alpha	alpha	NN
cord-260476-whfyczcj	91	4	Motif	motif	NN
cord-260476-whfyczcj	91	5	and	and	CC
cord-260476-whfyczcj	91	6	Histidine	Histidine	NNP
cord-260476-whfyczcj	91	7	Aspartate	Aspartate	NNP
cord-260476-whfyczcj	91	8	domain	domain	NN
cord-260476-whfyczcj	91	9	-	-	HYPH
cord-260476-whfyczcj	91	10	containing	contain	VBG
cord-260476-whfyczcj	91	11	protein	protein	NN
cord-260476-whfyczcj	91	12	1	1	CD
cord-260476-whfyczcj	91	13	)	)	-RRB-
cord-260476-whfyczcj	91	14	also	also	RB
cord-260476-whfyczcj	91	15	targets	target	VBZ
cord-260476-whfyczcj	91	16	the	the	DT
cord-260476-whfyczcj	91	17	early	early	JJ
cord-260476-whfyczcj	91	18	phase	phase	NN
cord-260476-whfyczcj	91	19	of	of	IN
cord-260476-whfyczcj	91	20	viral	viral	JJ
cord-260476-whfyczcj	91	21	infection	infection	NN
cord-260476-whfyczcj	92	1	:	:	:
cord-260476-whfyczcj	92	2	this	this	DT
cord-260476-whfyczcj	92	3	deoxynucleotide	deoxynucleotide	JJ
cord-260476-whfyczcj	92	4	-	-	HYPH
cord-260476-whfyczcj	92	5	triphosphohydrolase	triphosphohydrolase	NN
cord-260476-whfyczcj	92	6	inhibits	inhibit	VBZ
cord-260476-whfyczcj	92	7	reverse	reverse	JJ
cord-260476-whfyczcj	92	8	transcription	transcription	NN
cord-260476-whfyczcj	92	9	by	by	IN
cord-260476-whfyczcj	92	10	depleting	deplete	VBG
cord-260476-whfyczcj	92	11	the	the	DT
cord-260476-whfyczcj	92	12	pool	pool	NN
cord-260476-whfyczcj	92	13	of	of	IN
cord-260476-whfyczcj	92	14	cellular	cellular	JJ
cord-260476-whfyczcj	92	15	dNTPs	dntp	NNS
cord-260476-whfyczcj	92	16	(	(	-LRB-
cord-260476-whfyczcj	92	17	deoxy	deoxy	NNP
cord-260476-whfyczcj	92	18	Nucleotide	Nucleotide	NNP
cord-260476-whfyczcj	92	19	TriPhosphates	TriPhosphates	NNPS
cord-260476-whfyczcj	92	20	)	)	-RRB-
cord-260476-whfyczcj	92	21	[	[	-LRB-
cord-260476-whfyczcj	92	22	67	67	CD
cord-260476-whfyczcj	92	23	,	,	,
cord-260476-whfyczcj	92	24	68	68	CD
cord-260476-whfyczcj	92	25	]	]	-RRB-
cord-260476-whfyczcj	92	26	.	.	.
cord-260476-whfyczcj	93	1	During	during	IN
cord-260476-whfyczcj	93	2	reverse	reverse	JJ
cord-260476-whfyczcj	93	3	transcription	transcription	NN
cord-260476-whfyczcj	93	4	of	of	IN
cord-260476-whfyczcj	93	5	the	the	DT
cord-260476-whfyczcj	93	6	viral	viral	JJ
cord-260476-whfyczcj	93	7	RNA	RNA	NNP
cord-260476-whfyczcj	93	8	,	,	,
cord-260476-whfyczcj	93	9	the	the	DT
cord-260476-whfyczcj	93	10	restriction	restriction	NN
cord-260476-whfyczcj	93	11	factor	factor	NN
cord-260476-whfyczcj	93	12	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	93	13	G	g	NN
cord-260476-whfyczcj	93	14	(	(	-LRB-
cord-260476-whfyczcj	93	15	APOlipoprotein	APOlipoprotein	NNP
cord-260476-whfyczcj	93	16	B	B	NNP
cord-260476-whfyczcj	93	17	mRNA	mrna	NN
cord-260476-whfyczcj	93	18	Editing	editing	NN
cord-260476-whfyczcj	93	19	enzyme	enzyme	NN
cord-260476-whfyczcj	93	20	,	,	,
cord-260476-whfyczcj	93	21	Catalytic	catalytic	JJ
cord-260476-whfyczcj	93	22	polypeptide	polypeptide	NN
cord-260476-whfyczcj	93	23	-	-	:
cord-260476-whfyczcj	93	24	like	like	JJ
cord-260476-whfyczcj	93	25	3	3	CD
cord-260476-whfyczcj	93	26	G	g	NN
cord-260476-whfyczcj	93	27	,	,	,
cord-260476-whfyczcj	93	28	or	or	CC
cord-260476-whfyczcj	93	29	A3	A3	NNP
cord-260476-whfyczcj	93	30	G	G	NNP
cord-260476-whfyczcj	93	31	)	)	-RRB-
cord-260476-whfyczcj	93	32	and	and	CC
cord-260476-whfyczcj	93	33	other	other	JJ
cord-260476-whfyczcj	93	34	factors	factor	NNS
cord-260476-whfyczcj	93	35	from	from	IN
cord-260476-whfyczcj	93	36	the	the	DT
cord-260476-whfyczcj	93	37	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	93	38	family	family	NN
cord-260476-whfyczcj	93	39	,	,	,
cord-260476-whfyczcj	93	40	can	can	MD
cord-260476-whfyczcj	93	41	induce	induce	VB
cord-260476-whfyczcj	93	42	G	g	NN
cord-260476-whfyczcj	93	43	to	to	IN
cord-260476-whfyczcj	93	44	A	a	DT
cord-260476-whfyczcj	93	45	hypermutations	hypermutation	NNS
cord-260476-whfyczcj	93	46	,	,	,
cord-260476-whfyczcj	93	47	which	which	WDT
cord-260476-whfyczcj	93	48	prevent	prevent	VBP
cord-260476-whfyczcj	93	49	production	production	NN
cord-260476-whfyczcj	93	50	of	of	IN
cord-260476-whfyczcj	93	51	functional	functional	JJ
cord-260476-whfyczcj	93	52	viral	viral	JJ
cord-260476-whfyczcj	93	53	proteins	protein	NNS
cord-260476-whfyczcj	93	54	[	[	-LRB-
cord-260476-whfyczcj	93	55	69	69	CD
cord-260476-whfyczcj	93	56	]	]	-RRB-
cord-260476-whfyczcj	93	57	[	[	-LRB-
cord-260476-whfyczcj	93	58	70	70	CD
cord-260476-whfyczcj	93	59	]	]	-RRB-
cord-260476-whfyczcj	93	60	[	[	-LRB-
cord-260476-whfyczcj	93	61	71	71	CD
cord-260476-whfyczcj	93	62	]	]	-RRB-
cord-260476-whfyczcj	93	63	.	.	.
cord-260476-whfyczcj	94	1	The	the	DT
cord-260476-whfyczcj	94	2	amount	amount	NN
cord-260476-whfyczcj	94	3	of	of	IN
cord-260476-whfyczcj	94	4	viral	viral	JJ
cord-260476-whfyczcj	94	5	proteins	protein	NNS
cord-260476-whfyczcj	94	6	that	that	WDT
cord-260476-whfyczcj	94	7	are	be	VBP
cord-260476-whfyczcj	94	8	produced	produce	VBN
cord-260476-whfyczcj	94	9	in	in	IN
cord-260476-whfyczcj	94	10	an	an	DT
cord-260476-whfyczcj	94	11	infected	infected	JJ
cord-260476-whfyczcj	94	12	cell	cell	NN
cord-260476-whfyczcj	94	13	can	can	MD
cord-260476-whfyczcj	94	14	be	be	VB
cord-260476-whfyczcj	94	15	limited	limit	VBN
cord-260476-whfyczcj	94	16	by	by	IN
cord-260476-whfyczcj	94	17	Schlafen11	Schlafen11	NNP
cord-260476-whfyczcj	94	18	(	(	-LRB-
cord-260476-whfyczcj	94	19	SLFN11	SLFN11	NNP
cord-260476-whfyczcj	94	20	)	)	-RRB-
cord-260476-whfyczcj	94	21	.	.	.
cord-260476-whfyczcj	95	1	Due	due	IN
cord-260476-whfyczcj	95	2	to	to	IN
cord-260476-whfyczcj	95	3	the	the	DT
cord-260476-whfyczcj	95	4	bias	bias	NN
cord-260476-whfyczcj	95	5	of	of	IN
cord-260476-whfyczcj	95	6	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	95	7	towards	towards	IN
cord-260476-whfyczcj	95	8	A	A	NNP
cord-260476-whfyczcj	95	9	/	/	SYM
cord-260476-whfyczcj	95	10	U	U	NNP
cord-260476-whfyczcj	95	11	rich	rich	JJ
cord-260476-whfyczcj	95	12	codons	codon	NNS
cord-260476-whfyczcj	95	13	,	,	,
cord-260476-whfyczcj	95	14	the	the	DT
cord-260476-whfyczcj	95	15	virus	virus	NN
cord-260476-whfyczcj	95	16	stimulates	stimulate	VBZ
cord-260476-whfyczcj	95	17	production	production	NN
cord-260476-whfyczcj	95	18	of	of	IN
cord-260476-whfyczcj	95	19	corresponding	correspond	VBG
cord-260476-whfyczcj	95	20	tRNAs	trna	NNS
cord-260476-whfyczcj	95	21	by	by	IN
cord-260476-whfyczcj	95	22	the	the	DT
cord-260476-whfyczcj	95	23	cell	cell	NN
cord-260476-whfyczcj	95	24	to	to	TO
cord-260476-whfyczcj	95	25	increase	increase	VB
cord-260476-whfyczcj	95	26	viral	viral	JJ
cord-260476-whfyczcj	95	27	translation	translation	NN
cord-260476-whfyczcj	95	28	,	,	,
cord-260476-whfyczcj	95	29	a	a	DT
cord-260476-whfyczcj	95	30	mechanism	mechanism	NN
cord-260476-whfyczcj	95	31	that	that	WDT
cord-260476-whfyczcj	95	32	seems	seem	VBZ
cord-260476-whfyczcj	95	33	to	to	TO
cord-260476-whfyczcj	95	34	be	be	VB
cord-260476-whfyczcj	95	35	partly	partly	RB
cord-260476-whfyczcj	95	36	counteracted	counteract	VBN
cord-260476-whfyczcj	95	37	by	by	IN
cord-260476-whfyczcj	95	38	SLFN11	SLFN11	NNP
cord-260476-whfyczcj	95	39	,	,	,
cord-260476-whfyczcj	95	40	which	which	WDT
cord-260476-whfyczcj	95	41	binds	bind	VBZ
cord-260476-whfyczcj	95	42	tRNAs	trna	NNS
cord-260476-whfyczcj	95	43	in	in	IN
cord-260476-whfyczcj	95	44	a	a	DT
cord-260476-whfyczcj	95	45	codon	codon	NN
cord-260476-whfyczcj	95	46	-	-	HYPH
cord-260476-whfyczcj	95	47	specific	specific	JJ
cord-260476-whfyczcj	95	48	manner	manner	NN
cord-260476-whfyczcj	95	49	[	[	-LRB-
cord-260476-whfyczcj	95	50	72	72	CD
cord-260476-whfyczcj	95	51	]	]	-RRB-
cord-260476-whfyczcj	96	1	[	[	-LRB-
cord-260476-whfyczcj	96	2	73	73	CD
cord-260476-whfyczcj	96	3	]	]	-RRB-
cord-260476-whfyczcj	96	4	[	[	-LRB-
cord-260476-whfyczcj	96	5	74	74	CD
cord-260476-whfyczcj	96	6	]	]	-RRB-
cord-260476-whfyczcj	96	7	.	.	.
cord-260476-whfyczcj	97	1	The	the	DT
cord-260476-whfyczcj	97	2	final	final	JJ
cord-260476-whfyczcj	97	3	steps	step	NNS
cord-260476-whfyczcj	97	4	in	in	IN
cord-260476-whfyczcj	97	5	the	the	DT
cord-260476-whfyczcj	97	6	viral	viral	JJ
cord-260476-whfyczcj	97	7	life	life	NN
cord-260476-whfyczcj	97	8	cycle	cycle	NN
cord-260476-whfyczcj	97	9	can	can	MD
cord-260476-whfyczcj	97	10	be	be	VB
cord-260476-whfyczcj	97	11	targeted	target	VBN
cord-260476-whfyczcj	97	12	by	by	IN
cord-260476-whfyczcj	97	13	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	97	14	/	/	SYM
cord-260476-whfyczcj	97	15	BST2	BST2	NNP
cord-260476-whfyczcj	97	16	(	(	-LRB-
cord-260476-whfyczcj	97	17	Bone	bone	NN
cord-260476-whfyczcj	97	18	marrow	marrow	NN
cord-260476-whfyczcj	97	19	STromal	stromal	JJ
cord-260476-whfyczcj	97	20	antigen	antigen	NN
cord-260476-whfyczcj	97	21	2	2	CD
cord-260476-whfyczcj	97	22	)	)	-RRB-
cord-260476-whfyczcj	97	23	,	,	,
cord-260476-whfyczcj	97	24	which	which	WDT
cord-260476-whfyczcj	97	25	inhibits	inhibit	VBZ
cord-260476-whfyczcj	97	26	release	release	NN
cord-260476-whfyczcj	97	27	of	of	IN
cord-260476-whfyczcj	97	28	new	new	JJ
cord-260476-whfyczcj	97	29	viral	viral	JJ
cord-260476-whfyczcj	97	30	particles	particle	NNS
cord-260476-whfyczcj	97	31	from	from	IN
cord-260476-whfyczcj	97	32	the	the	DT
cord-260476-whfyczcj	97	33	host	host	NN
cord-260476-whfyczcj	97	34	cell	cell	NN
cord-260476-whfyczcj	97	35	[	[	-LRB-
cord-260476-whfyczcj	97	36	75	75	CD
cord-260476-whfyczcj	97	37	]	]	-RRB-
cord-260476-whfyczcj	97	38	[	[	-LRB-
cord-260476-whfyczcj	97	39	76	76	CD
cord-260476-whfyczcj	97	40	]	]	-RRB-
cord-260476-whfyczcj	97	41	[	[	-LRB-
cord-260476-whfyczcj	97	42	77	77	CD
cord-260476-whfyczcj	97	43	]	]	-RRB-
cord-260476-whfyczcj	97	44	and	and	CC
cord-260476-whfyczcj	97	45	March8	March8	NNP
cord-260476-whfyczcj	98	1	(	(	-LRB-
cord-260476-whfyczcj	98	2	Membrane	membrane	NN
cord-260476-whfyczcj	98	3	-	-	HYPH
cord-260476-whfyczcj	98	4	Associated	Associated	NNP
cord-260476-whfyczcj	98	5	RING	ring	NN
cord-260476-whfyczcj	98	6	-	-	HYPH
cord-260476-whfyczcj	98	7	CH	CH	NNP
cord-260476-whfyczcj	98	8	8	8	CD
cord-260476-whfyczcj	98	9	protein	protein	NN
cord-260476-whfyczcj	98	10	)	)	-RRB-
cord-260476-whfyczcj	98	11	,	,	,
cord-260476-whfyczcj	98	12	which	which	WDT
cord-260476-whfyczcj	98	13	decreases	decrease	VBZ
cord-260476-whfyczcj	98	14	incorporation	incorporation	NN
cord-260476-whfyczcj	98	15	of	of	IN
cord-260476-whfyczcj	98	16	envelope	envelope	NN
cord-260476-whfyczcj	98	17	proteins	protein	NNS
cord-260476-whfyczcj	98	18	into	into	IN
cord-260476-whfyczcj	98	19	newly	newly	RB
cord-260476-whfyczcj	98	20	produced	produce	VBN
cord-260476-whfyczcj	98	21	virions	virion	NNS
cord-260476-whfyczcj	98	22	,	,	,
cord-260476-whfyczcj	98	23	thereby	thereby	RB
cord-260476-whfyczcj	98	24	decreasing	decrease	VBG
cord-260476-whfyczcj	98	25	their	-PRON-	PRP$
cord-260476-whfyczcj	98	26	infectivity	infectivity	NN
cord-260476-whfyczcj	98	27	[	[	-LRB-
cord-260476-whfyczcj	98	28	78	78	CD
cord-260476-whfyczcj	98	29	]	]	-RRB-
cord-260476-whfyczcj	98	30	.	.	.
cord-260476-whfyczcj	99	1	Two	two	CD
cord-260476-whfyczcj	99	2	of	of	IN
cord-260476-whfyczcj	99	3	these	these	DT
cord-260476-whfyczcj	99	4	restriction	restriction	NN
cord-260476-whfyczcj	99	5	factors	factor	NNS
cord-260476-whfyczcj	99	6	,	,	,
cord-260476-whfyczcj	99	7	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	99	8	and	and	CC
cord-260476-whfyczcj	99	9	March8	March8	NNP
cord-260476-whfyczcj	99	10	,	,	,
cord-260476-whfyczcj	99	11	use	use	VB
cord-260476-whfyczcj	99	12	the	the	DT
cord-260476-whfyczcj	99	13	UPS	up	NNS
cord-260476-whfyczcj	99	14	to	to	TO
cord-260476-whfyczcj	99	15	exert	exert	VB
cord-260476-whfyczcj	99	16	their	-PRON-	PRP$
cord-260476-whfyczcj	99	17	restricting	restrict	VBG
cord-260476-whfyczcj	99	18	activity	activity	NN
cord-260476-whfyczcj	99	19	.	.	.
cord-260476-whfyczcj	100	1	HIV	HIV	NNP
cord-260476-whfyczcj	100	2	is	be	VBZ
cord-260476-whfyczcj	100	3	able	able	JJ
cord-260476-whfyczcj	100	4	to	to	TO
cord-260476-whfyczcj	100	5	counteract	counteract	VB
cord-260476-whfyczcj	100	6	restriction	restriction	NN
cord-260476-whfyczcj	100	7	factors	factor	NNS
cord-260476-whfyczcj	100	8	using	use	VBG
cord-260476-whfyczcj	100	9	its	-PRON-	PRP$
cord-260476-whfyczcj	100	10	accessory	accessory	NN
cord-260476-whfyczcj	100	11	proteins	protein	NNS
cord-260476-whfyczcj	100	12	(	(	-LRB-
cord-260476-whfyczcj	100	13	Figure	figure	NN
cord-260476-whfyczcj	100	14	2	2	CD
cord-260476-whfyczcj	101	1	):	):	NNP
cord-260476-whfyczcj	101	2	Nef	Nef	NNP
cord-260476-whfyczcj	101	3	prevents	prevent	VBZ
cord-260476-whfyczcj	101	4	SERINC5	serinc5	RB
cord-260476-whfyczcj	101	5	incorporation	incorporation	NN
cord-260476-whfyczcj	101	6	into	into	IN
cord-260476-whfyczcj	101	7	virions	virion	NNS
cord-260476-whfyczcj	101	8	by	by	IN
cord-260476-whfyczcj	101	9	mediating	mediate	VBG
cord-260476-whfyczcj	101	10	its	-PRON-	PRP$
cord-260476-whfyczcj	101	11	relocalization	relocalization	NN
cord-260476-whfyczcj	101	12	to	to	IN
cord-260476-whfyczcj	101	13	late	late	JJ
cord-260476-whfyczcj	101	14	endosomes	endosome	NNS
cord-260476-whfyczcj	101	15	through	through	IN
cord-260476-whfyczcj	101	16	interaction	interaction	NN
cord-260476-whfyczcj	101	17	with	with	IN
cord-260476-whfyczcj	101	18	the	the	DT
cord-260476-whfyczcj	101	19	clathrin	clathrin	NN
cord-260476-whfyczcj	101	20	adaptor	adaptor	NN
cord-260476-whfyczcj	102	1	AP-2	AP-2	NNP
cord-260476-whfyczcj	102	2	[	[	-LRB-
cord-260476-whfyczcj	102	3	50	50	CD
cord-260476-whfyczcj	102	4	,	,	,
cord-260476-whfyczcj	102	5	79	79	CD
cord-260476-whfyczcj	102	6	]	]	-RRB-
cord-260476-whfyczcj	102	7	.	.	.
cord-260476-whfyczcj	103	1	Vif	Vif	NNP
cord-260476-whfyczcj	103	2	counteracts	counteract	VBZ
cord-260476-whfyczcj	103	3	A3	A3	NNP
cord-260476-whfyczcj	103	4	G	G	NNP
cord-260476-whfyczcj	103	5	by	by	IN
cord-260476-whfyczcj	103	6	inducing	induce	VBG
cord-260476-whfyczcj	103	7	its	-PRON-	PRP$
cord-260476-whfyczcj	103	8	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	103	9	degradation	degradation	NN
cord-260476-whfyczcj	103	10	as	as	RB
cord-260476-whfyczcj	103	11	well	well	RB
cord-260476-whfyczcj	103	12	as	as	IN
cord-260476-whfyczcj	103	13	by	by	IN
cord-260476-whfyczcj	103	14	reducing	reduce	VBG
cord-260476-whfyczcj	103	15	its	-PRON-	PRP$
cord-260476-whfyczcj	103	16	transcription	transcription	NN
cord-260476-whfyczcj	103	17	and	and	CC
cord-260476-whfyczcj	103	18	translation	translation	NN
cord-260476-whfyczcj	103	19	[	[	-LRB-
cord-260476-whfyczcj	103	20	69	69	CD
cord-260476-whfyczcj	103	21	,	,	,
cord-260476-whfyczcj	103	22	[	[	-LRB-
cord-260476-whfyczcj	103	23	80	80	CD
cord-260476-whfyczcj	103	24	]	]	-RRB-
cord-260476-whfyczcj	103	25	[	[	-LRB-
cord-260476-whfyczcj	103	26	81	81	CD
cord-260476-whfyczcj	103	27	]	]	-RRB-
cord-260476-whfyczcj	103	28	[	[	-LRB-
cord-260476-whfyczcj	103	29	82	82	CD
cord-260476-whfyczcj	103	30	]	]	-RRB-
cord-260476-whfyczcj	103	31	.	.	.
cord-260476-whfyczcj	104	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	104	2	(	(	-LRB-
cord-260476-whfyczcj	104	3	and	and	CC
cord-260476-whfyczcj	104	4	Vpr	Vpr	NNP
cord-260476-whfyczcj	104	5	of	of	IN
cord-260476-whfyczcj	104	6	certain	certain	JJ
cord-260476-whfyczcj	104	7	Simian	simian	JJ
cord-260476-whfyczcj	104	8	Immunodeficiency	Immunodeficiency	NNP
cord-260476-whfyczcj	104	9	Virus	Virus	NNP
cord-260476-whfyczcj	104	10	(	(	-LRB-
cord-260476-whfyczcj	104	11	SIV	SIV	NNP
cord-260476-whfyczcj	104	12	)	)	-RRB-
cord-260476-whfyczcj	104	13	strains	strain	NNS
cord-260476-whfyczcj	104	14	)	)	-RRB-
cord-260476-whfyczcj	104	15	counteracts	counteract	VBZ
cord-260476-whfyczcj	104	16	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	104	17	by	by	IN
cord-260476-whfyczcj	104	18	inducing	induce	VBG
cord-260476-whfyczcj	104	19	its	-PRON-	PRP$
cord-260476-whfyczcj	104	20	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	104	21	degradation	degradation	NN
cord-260476-whfyczcj	104	22	[	[	-LRB-
cord-260476-whfyczcj	104	23	67	67	CD
cord-260476-whfyczcj	104	24	,	,	,
cord-260476-whfyczcj	104	25	83	83	CD
cord-260476-whfyczcj	104	26	,	,	,
cord-260476-whfyczcj	104	27	84	84	CD
cord-260476-whfyczcj	104	28	]	]	-RRB-
cord-260476-whfyczcj	104	29	.	.	.
cord-260476-whfyczcj	105	1	Vpu	Vpu	NNP
cord-260476-whfyczcj	105	2	(	(	-LRB-
cord-260476-whfyczcj	105	3	Env	Env	NNP
cord-260476-whfyczcj	105	4	for	for	IN
cord-260476-whfyczcj	105	5	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	105	6	and	and	CC
cord-260476-whfyczcj	105	7	Nef	Nef	NNP
cord-260476-whfyczcj	105	8	or	or	CC
cord-260476-whfyczcj	105	9	Vpu	Vpu	NNP
cord-260476-whfyczcj	105	10	for	for	IN
cord-260476-whfyczcj	105	11	SIV	SIV	NNP
cord-260476-whfyczcj	105	12	)	)	-RRB-
cord-260476-whfyczcj	105	13	counteracts	counteract	VBZ
cord-260476-whfyczcj	105	14	BST2	BST2	NNP
cord-260476-whfyczcj	105	15	/	/	SYM
cord-260476-whfyczcj	105	16	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	105	17	by	by	IN
cord-260476-whfyczcj	105	18	sequestering	sequester	VBG
cord-260476-whfyczcj	105	19	it	-PRON-	PRP
cord-260476-whfyczcj	105	20	away	away	RB
cord-260476-whfyczcj	105	21	from	from	IN
cord-260476-whfyczcj	105	22	sites	site	NNS
cord-260476-whfyczcj	105	23	of	of	IN
cord-260476-whfyczcj	105	24	viral	viral	JJ
cord-260476-whfyczcj	105	25	budding	bud	VBG
cord-260476-whfyczcj	105	26	[	[	-LRB-
cord-260476-whfyczcj	105	27	76	76	CD
cord-260476-whfyczcj	105	28	,	,	,
cord-260476-whfyczcj	105	29	77	77	CD
cord-260476-whfyczcj	105	30	,	,	,
cord-260476-whfyczcj	105	31	85	85	CD
cord-260476-whfyczcj	105	32	]	]	-RRB-
cord-260476-whfyczcj	105	33	.	.	.
cord-260476-whfyczcj	106	1	Amongst	amongst	IN
cord-260476-whfyczcj	106	2	these	these	DT
cord-260476-whfyczcj	106	3	accessory	accessory	NN
cord-260476-whfyczcj	106	4	proteins	protein	NNS
cord-260476-whfyczcj	106	5	,	,	,
cord-260476-whfyczcj	106	6	Vif	Vif	NNP
cord-260476-whfyczcj	106	7	,	,	,
cord-260476-whfyczcj	106	8	Vpx	Vpx	NNP
cord-260476-whfyczcj	106	9	and	and	CC
cord-260476-whfyczcj	106	10	Vpu	Vpu	NNP
cord-260476-whfyczcj	106	11	hijack	hijack	VBP
cord-260476-whfyczcj	106	12	the	the	DT
cord-260476-whfyczcj	106	13	UPS	up	NNS
cord-260476-whfyczcj	106	14	to	to	TO
cord-260476-whfyczcj	106	15	exert	exert	VB
cord-260476-whfyczcj	106	16	their	-PRON-	PRP$
cord-260476-whfyczcj	106	17	counter	counter	JJ
cord-260476-whfyczcj	106	18	-	-	NN
cord-260476-whfyczcj	106	19	defense	defense	NN
cord-260476-whfyczcj	106	20	.	.	.
cord-260476-whfyczcj	107	1	In	in	IN
cord-260476-whfyczcj	107	2	the	the	DT
cord-260476-whfyczcj	107	3	following	following	JJ
cord-260476-whfyczcj	107	4	section	section	NN
cord-260476-whfyczcj	107	5	,	,	,
cord-260476-whfyczcj	107	6	we	-PRON-	PRP
cord-260476-whfyczcj	107	7	will	will	MD
cord-260476-whfyczcj	107	8	discuss	discuss	VB
cord-260476-whfyczcj	107	9	in	in	IN
cord-260476-whfyczcj	107	10	detail	detail	NN
cord-260476-whfyczcj	107	11	the	the	DT
cord-260476-whfyczcj	107	12	restriction	restriction	NN
cord-260476-whfyczcj	107	13	factors	factor	NNS
cord-260476-whfyczcj	107	14	as	as	RB
cord-260476-whfyczcj	107	15	well	well	RB
cord-260476-whfyczcj	107	16	as	as	IN
cord-260476-whfyczcj	107	17	the	the	DT
cord-260476-whfyczcj	107	18	viral	viral	JJ
cord-260476-whfyczcj	107	19	proteins	protein	NNS
cord-260476-whfyczcj	107	20	which	which	WDT
cord-260476-whfyczcj	107	21	use	use	VBP
cord-260476-whfyczcj	107	22	the	the	DT
cord-260476-whfyczcj	107	23	UPS	up	NNS
cord-260476-whfyczcj	107	24	for	for	IN
cord-260476-whfyczcj	107	25	their	-PRON-	PRP$
cord-260476-whfyczcj	107	26	respective	respective	JJ
cord-260476-whfyczcj	107	27	mechanisms	mechanism	NNS
cord-260476-whfyczcj	107	28	.	.	.
cord-260476-whfyczcj	108	1	infected	infected	JJ
cord-260476-whfyczcj	108	2	cell	cell	NN
cord-260476-whfyczcj	108	3	can	can	MD
cord-260476-whfyczcj	108	4	be	be	VB
cord-260476-whfyczcj	108	5	limited	limit	VBN
cord-260476-whfyczcj	108	6	by	by	IN
cord-260476-whfyczcj	108	7	Schlafen11	Schlafen11	NNP
cord-260476-whfyczcj	108	8	(	(	-LRB-
cord-260476-whfyczcj	108	9	SLFN11	SLFN11	NNP
cord-260476-whfyczcj	108	10	)	)	-RRB-
cord-260476-whfyczcj	108	11	.	.	.
cord-260476-whfyczcj	109	1	Due	due	IN
cord-260476-whfyczcj	109	2	to	to	IN
cord-260476-whfyczcj	109	3	the	the	DT
cord-260476-whfyczcj	109	4	bias	bias	NN
cord-260476-whfyczcj	109	5	of	of	IN
cord-260476-whfyczcj	109	6	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	109	7	towards	towards	IN
cord-260476-whfyczcj	109	8	A	A	NNP
cord-260476-whfyczcj	109	9	/	/	SYM
cord-260476-whfyczcj	109	10	U	U	NNP
cord-260476-whfyczcj	109	11	rich	rich	JJ
cord-260476-whfyczcj	109	12	codons	codon	NNS
cord-260476-whfyczcj	109	13	,	,	,
cord-260476-whfyczcj	109	14	the	the	DT
cord-260476-whfyczcj	109	15	virus	virus	NN
cord-260476-whfyczcj	109	16	stimulates	stimulate	VBZ
cord-260476-whfyczcj	109	17	production	production	NN
cord-260476-whfyczcj	109	18	of	of	IN
cord-260476-whfyczcj	109	19	corresponding	correspond	VBG
cord-260476-whfyczcj	109	20	tRNAs	trna	NNS
cord-260476-whfyczcj	109	21	by	by	IN
cord-260476-whfyczcj	109	22	the	the	DT
cord-260476-whfyczcj	109	23	cell	cell	NN
cord-260476-whfyczcj	109	24	to	to	TO
cord-260476-whfyczcj	109	25	increase	increase	VB
cord-260476-whfyczcj	109	26	viral	viral	JJ
cord-260476-whfyczcj	109	27	translation	translation	NN
cord-260476-whfyczcj	109	28	,	,	,
cord-260476-whfyczcj	109	29	a	a	DT
cord-260476-whfyczcj	109	30	mechanism	mechanism	NN
cord-260476-whfyczcj	109	31	that	that	WDT
cord-260476-whfyczcj	109	32	seems	seem	VBZ
cord-260476-whfyczcj	109	33	to	to	TO
cord-260476-whfyczcj	109	34	be	be	VB
cord-260476-whfyczcj	109	35	partly	partly	RB
cord-260476-whfyczcj	109	36	counteracted	counteract	VBN
cord-260476-whfyczcj	109	37	by	by	IN
cord-260476-whfyczcj	109	38	SLFN11	SLFN11	NNP
cord-260476-whfyczcj	109	39	,	,	,
cord-260476-whfyczcj	109	40	which	which	WDT
cord-260476-whfyczcj	109	41	binds	bind	VBZ
cord-260476-whfyczcj	109	42	tRNAs	trna	NNS
cord-260476-whfyczcj	109	43	in	in	IN
cord-260476-whfyczcj	109	44	a	a	DT
cord-260476-whfyczcj	109	45	codon	codon	NN
cord-260476-whfyczcj	109	46	-	-	HYPH
cord-260476-whfyczcj	109	47	specific	specific	JJ
cord-260476-whfyczcj	109	48	manner	manner	NN
cord-260476-whfyczcj	109	49	[	[	-LRB-
cord-260476-whfyczcj	109	50	72	72	CD
cord-260476-whfyczcj	109	51	]	]	-RRB-
cord-260476-whfyczcj	110	1	[	[	-LRB-
cord-260476-whfyczcj	110	2	73	73	CD
cord-260476-whfyczcj	110	3	]	]	-RRB-
cord-260476-whfyczcj	110	4	[	[	-LRB-
cord-260476-whfyczcj	110	5	74	74	CD
cord-260476-whfyczcj	110	6	]	]	-RRB-
cord-260476-whfyczcj	110	7	.	.	.
cord-260476-whfyczcj	111	1	The	the	DT
cord-260476-whfyczcj	111	2	final	final	JJ
cord-260476-whfyczcj	111	3	steps	step	NNS
cord-260476-whfyczcj	111	4	in	in	IN
cord-260476-whfyczcj	111	5	the	the	DT
cord-260476-whfyczcj	111	6	viral	viral	JJ
cord-260476-whfyczcj	111	7	life	life	NN
cord-260476-whfyczcj	111	8	cycle	cycle	NN
cord-260476-whfyczcj	111	9	can	can	MD
cord-260476-whfyczcj	111	10	be	be	VB
cord-260476-whfyczcj	111	11	targeted	target	VBN
cord-260476-whfyczcj	111	12	by	by	IN
cord-260476-whfyczcj	111	13	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	111	14	/	/	SYM
cord-260476-whfyczcj	111	15	BST2	BST2	NNP
cord-260476-whfyczcj	111	16	(	(	-LRB-
cord-260476-whfyczcj	111	17	Bone	bone	NN
cord-260476-whfyczcj	111	18	marrow	marrow	NN
cord-260476-whfyczcj	111	19	STromal	stromal	JJ
cord-260476-whfyczcj	111	20	antigen	antigen	NN
cord-260476-whfyczcj	111	21	2	2	CD
cord-260476-whfyczcj	111	22	)	)	-RRB-
cord-260476-whfyczcj	111	23	,	,	,
cord-260476-whfyczcj	111	24	which	which	WDT
cord-260476-whfyczcj	111	25	inhibits	inhibit	VBZ
cord-260476-whfyczcj	111	26	release	release	NN
cord-260476-whfyczcj	111	27	of	of	IN
cord-260476-whfyczcj	111	28	new	new	JJ
cord-260476-whfyczcj	111	29	viral	viral	JJ
cord-260476-whfyczcj	111	30	particles	particle	NNS
cord-260476-whfyczcj	111	31	from	from	IN
cord-260476-whfyczcj	111	32	the	the	DT
cord-260476-whfyczcj	111	33	host	host	NN
cord-260476-whfyczcj	111	34	cell	cell	NN
cord-260476-whfyczcj	111	35	[	[	-LRB-
cord-260476-whfyczcj	111	36	75	75	CD
cord-260476-whfyczcj	111	37	]	]	-RRB-
cord-260476-whfyczcj	111	38	[	[	-LRB-
cord-260476-whfyczcj	111	39	76	76	CD
cord-260476-whfyczcj	111	40	]	]	-RRB-
cord-260476-whfyczcj	111	41	[	[	-LRB-
cord-260476-whfyczcj	111	42	77	77	CD
cord-260476-whfyczcj	111	43	]	]	-RRB-
cord-260476-whfyczcj	111	44	and	and	CC
cord-260476-whfyczcj	111	45	March8	March8	NNP
cord-260476-whfyczcj	112	1	(	(	-LRB-
cord-260476-whfyczcj	112	2	Membrane	membrane	NN
cord-260476-whfyczcj	112	3	-	-	HYPH
cord-260476-whfyczcj	112	4	Associated	Associated	NNP
cord-260476-whfyczcj	112	5	RING	ring	NN
cord-260476-whfyczcj	112	6	-	-	HYPH
cord-260476-whfyczcj	112	7	CH	CH	NNP
cord-260476-whfyczcj	112	8	8	8	CD
cord-260476-whfyczcj	112	9	protein	protein	NN
cord-260476-whfyczcj	112	10	)	)	-RRB-
cord-260476-whfyczcj	112	11	,	,	,
cord-260476-whfyczcj	112	12	which	which	WDT
cord-260476-whfyczcj	112	13	decreases	decrease	VBZ
cord-260476-whfyczcj	112	14	incorporation	incorporation	NN
cord-260476-whfyczcj	112	15	of	of	IN
cord-260476-whfyczcj	112	16	envelope	envelope	NN
cord-260476-whfyczcj	112	17	proteins	protein	NNS
cord-260476-whfyczcj	112	18	into	into	IN
cord-260476-whfyczcj	112	19	newly	newly	RB
cord-260476-whfyczcj	112	20	produced	produce	VBN
cord-260476-whfyczcj	112	21	virions	virion	NNS
cord-260476-whfyczcj	112	22	,	,	,
cord-260476-whfyczcj	112	23	thereby	thereby	RB
cord-260476-whfyczcj	112	24	decreasing	decrease	VBG
cord-260476-whfyczcj	112	25	their	-PRON-	PRP$
cord-260476-whfyczcj	112	26	infectivity	infectivity	NN
cord-260476-whfyczcj	112	27	[	[	-LRB-
cord-260476-whfyczcj	112	28	78	78	CD
cord-260476-whfyczcj	112	29	]	]	-RRB-
cord-260476-whfyczcj	112	30	.	.	.
cord-260476-whfyczcj	113	1	Two	two	CD
cord-260476-whfyczcj	113	2	of	of	IN
cord-260476-whfyczcj	113	3	these	these	DT
cord-260476-whfyczcj	113	4	restriction	restriction	NN
cord-260476-whfyczcj	113	5	factors	factor	NNS
cord-260476-whfyczcj	113	6	,	,	,
cord-260476-whfyczcj	113	7	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	113	8	and	and	CC
cord-260476-whfyczcj	113	9	March8	March8	NNP
cord-260476-whfyczcj	113	10	,	,	,
cord-260476-whfyczcj	113	11	use	use	VB
cord-260476-whfyczcj	113	12	the	the	DT
cord-260476-whfyczcj	113	13	UPS	up	NNS
cord-260476-whfyczcj	113	14	to	to	TO
cord-260476-whfyczcj	113	15	exert	exert	VB
cord-260476-whfyczcj	113	16	their	-PRON-	PRP$
cord-260476-whfyczcj	113	17	restricting	restrict	VBG
cord-260476-whfyczcj	113	18	activity	activity	NN
cord-260476-whfyczcj	113	19	.	.	.
cord-260476-whfyczcj	114	1	HIV	HIV	NNP
cord-260476-whfyczcj	114	2	is	be	VBZ
cord-260476-whfyczcj	114	3	able	able	JJ
cord-260476-whfyczcj	114	4	to	to	TO
cord-260476-whfyczcj	114	5	counteract	counteract	VB
cord-260476-whfyczcj	114	6	restriction	restriction	NN
cord-260476-whfyczcj	114	7	factors	factor	NNS
cord-260476-whfyczcj	114	8	using	use	VBG
cord-260476-whfyczcj	114	9	its	-PRON-	PRP$
cord-260476-whfyczcj	114	10	accessory	accessory	NN
cord-260476-whfyczcj	114	11	proteins	protein	NNS
cord-260476-whfyczcj	114	12	(	(	-LRB-
cord-260476-whfyczcj	114	13	Figure	figure	NN
cord-260476-whfyczcj	114	14	2	2	CD
cord-260476-whfyczcj	115	1	):	):	NNP
cord-260476-whfyczcj	115	2	Nef	Nef	NNP
cord-260476-whfyczcj	115	3	prevents	prevent	VBZ
cord-260476-whfyczcj	115	4	SERINC5	serinc5	RB
cord-260476-whfyczcj	115	5	incorporation	incorporation	NN
cord-260476-whfyczcj	115	6	into	into	IN
cord-260476-whfyczcj	115	7	virions	virion	NNS
cord-260476-whfyczcj	115	8	by	by	IN
cord-260476-whfyczcj	115	9	mediating	mediate	VBG
cord-260476-whfyczcj	115	10	its	-PRON-	PRP$
cord-260476-whfyczcj	115	11	relocalization	relocalization	NN
cord-260476-whfyczcj	115	12	to	to	IN
cord-260476-whfyczcj	115	13	late	late	JJ
cord-260476-whfyczcj	115	14	endosomes	endosome	NNS
cord-260476-whfyczcj	115	15	through	through	IN
cord-260476-whfyczcj	115	16	interaction	interaction	NN
cord-260476-whfyczcj	115	17	with	with	IN
cord-260476-whfyczcj	115	18	the	the	DT
cord-260476-whfyczcj	115	19	clathrin	clathrin	NN
cord-260476-whfyczcj	115	20	adaptor	adaptor	NN
cord-260476-whfyczcj	116	1	AP-2	AP-2	NNP
cord-260476-whfyczcj	116	2	[	[	-LRB-
cord-260476-whfyczcj	116	3	50	50	CD
cord-260476-whfyczcj	116	4	,	,	,
cord-260476-whfyczcj	116	5	79	79	CD
cord-260476-whfyczcj	116	6	]	]	-RRB-
cord-260476-whfyczcj	116	7	.	.	.
cord-260476-whfyczcj	117	1	Vif	Vif	NNP
cord-260476-whfyczcj	117	2	counteracts	counteract	VBZ
cord-260476-whfyczcj	117	3	A3	A3	NNP
cord-260476-whfyczcj	117	4	G	G	NNP
cord-260476-whfyczcj	117	5	by	by	IN
cord-260476-whfyczcj	117	6	inducing	induce	VBG
cord-260476-whfyczcj	117	7	its	-PRON-	PRP$
cord-260476-whfyczcj	117	8	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	117	9	degradation	degradation	NN
cord-260476-whfyczcj	117	10	as	as	RB
cord-260476-whfyczcj	117	11	well	well	RB
cord-260476-whfyczcj	117	12	as	as	IN
cord-260476-whfyczcj	117	13	by	by	IN
cord-260476-whfyczcj	117	14	reducing	reduce	VBG
cord-260476-whfyczcj	117	15	its	-PRON-	PRP$
cord-260476-whfyczcj	117	16	transcription	transcription	NN
cord-260476-whfyczcj	117	17	and	and	CC
cord-260476-whfyczcj	117	18	translation	translation	NN
cord-260476-whfyczcj	117	19	[	[	-LRB-
cord-260476-whfyczcj	117	20	69	69	CD
cord-260476-whfyczcj	117	21	,	,	,
cord-260476-whfyczcj	117	22	[	[	-LRB-
cord-260476-whfyczcj	117	23	80	80	CD
cord-260476-whfyczcj	117	24	]	]	-RRB-
cord-260476-whfyczcj	117	25	[	[	-LRB-
cord-260476-whfyczcj	117	26	81	81	CD
cord-260476-whfyczcj	117	27	]	]	-RRB-
cord-260476-whfyczcj	117	28	[	[	-LRB-
cord-260476-whfyczcj	117	29	82	82	CD
cord-260476-whfyczcj	117	30	]	]	-RRB-
cord-260476-whfyczcj	117	31	.	.	.
cord-260476-whfyczcj	118	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	118	2	(	(	-LRB-
cord-260476-whfyczcj	118	3	and	and	CC
cord-260476-whfyczcj	118	4	Vpr	Vpr	NNP
cord-260476-whfyczcj	118	5	of	of	IN
cord-260476-whfyczcj	118	6	certain	certain	JJ
cord-260476-whfyczcj	118	7	Simian	simian	JJ
cord-260476-whfyczcj	118	8	Immunodeficiency	Immunodeficiency	NNP
cord-260476-whfyczcj	118	9	Virus	Virus	NNP
cord-260476-whfyczcj	118	10	(	(	-LRB-
cord-260476-whfyczcj	118	11	SIV	SIV	NNP
cord-260476-whfyczcj	118	12	)	)	-RRB-
cord-260476-whfyczcj	118	13	strains	strain	NNS
cord-260476-whfyczcj	118	14	)	)	-RRB-
cord-260476-whfyczcj	118	15	counteracts	counteract	VBZ
cord-260476-whfyczcj	118	16	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	118	17	by	by	IN
cord-260476-whfyczcj	118	18	inducing	induce	VBG
cord-260476-whfyczcj	118	19	its	-PRON-	PRP$
cord-260476-whfyczcj	118	20	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	118	21	degradation	degradation	NN
cord-260476-whfyczcj	118	22	[	[	-LRB-
cord-260476-whfyczcj	118	23	67	67	CD
cord-260476-whfyczcj	118	24	,	,	,
cord-260476-whfyczcj	118	25	83	83	CD
cord-260476-whfyczcj	118	26	,	,	,
cord-260476-whfyczcj	118	27	84	84	CD
cord-260476-whfyczcj	118	28	]	]	-RRB-
cord-260476-whfyczcj	118	29	.	.	.
cord-260476-whfyczcj	119	1	Vpu	Vpu	NNP
cord-260476-whfyczcj	119	2	(	(	-LRB-
cord-260476-whfyczcj	119	3	Env	Env	NNP
cord-260476-whfyczcj	119	4	for	for	IN
cord-260476-whfyczcj	119	5	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	119	6	and	and	CC
cord-260476-whfyczcj	119	7	Nef	Nef	NNP
cord-260476-whfyczcj	119	8	or	or	CC
cord-260476-whfyczcj	119	9	Vpu	Vpu	NNP
cord-260476-whfyczcj	119	10	for	for	IN
cord-260476-whfyczcj	119	11	SIV	SIV	NNP
cord-260476-whfyczcj	119	12	)	)	-RRB-
cord-260476-whfyczcj	119	13	counteracts	counteract	VBZ
cord-260476-whfyczcj	119	14	BST2	BST2	NNP
cord-260476-whfyczcj	119	15	/	/	SYM
cord-260476-whfyczcj	119	16	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	119	17	by	by	IN
cord-260476-whfyczcj	119	18	sequestering	sequester	VBG
cord-260476-whfyczcj	119	19	it	-PRON-	PRP
cord-260476-whfyczcj	119	20	away	away	RB
cord-260476-whfyczcj	119	21	from	from	IN
cord-260476-whfyczcj	119	22	sites	site	NNS
cord-260476-whfyczcj	119	23	of	of	IN
cord-260476-whfyczcj	119	24	viral	viral	JJ
cord-260476-whfyczcj	119	25	budding	bud	VBG
cord-260476-whfyczcj	119	26	[	[	-LRB-
cord-260476-whfyczcj	119	27	76	76	CD
cord-260476-whfyczcj	119	28	,	,	,
cord-260476-whfyczcj	119	29	77	77	CD
cord-260476-whfyczcj	119	30	,	,	,
cord-260476-whfyczcj	119	31	85	85	CD
cord-260476-whfyczcj	119	32	]	]	-RRB-
cord-260476-whfyczcj	119	33	.	.	.
cord-260476-whfyczcj	120	1	Amongst	amongst	IN
cord-260476-whfyczcj	120	2	these	these	DT
cord-260476-whfyczcj	120	3	accessory	accessory	NN
cord-260476-whfyczcj	120	4	proteins	protein	NNS
cord-260476-whfyczcj	120	5	,	,	,
cord-260476-whfyczcj	120	6	Vif	Vif	NNP
cord-260476-whfyczcj	120	7	,	,	,
cord-260476-whfyczcj	120	8	Vpx	Vpx	NNP
cord-260476-whfyczcj	120	9	and	and	CC
cord-260476-whfyczcj	120	10	Vpu	Vpu	NNP
cord-260476-whfyczcj	120	11	hijack	hijack	VBP
cord-260476-whfyczcj	120	12	the	the	DT
cord-260476-whfyczcj	120	13	UPS	up	NNS
cord-260476-whfyczcj	120	14	to	to	TO
cord-260476-whfyczcj	120	15	exert	exert	VB
cord-260476-whfyczcj	120	16	their	-PRON-	PRP$
cord-260476-whfyczcj	120	17	counter	counter	JJ
cord-260476-whfyczcj	120	18	-	-	NN
cord-260476-whfyczcj	120	19	defense	defense	NN
cord-260476-whfyczcj	120	20	.	.	.
cord-260476-whfyczcj	121	1	In	in	IN
cord-260476-whfyczcj	121	2	the	the	DT
cord-260476-whfyczcj	121	3	following	following	JJ
cord-260476-whfyczcj	121	4	section	section	NN
cord-260476-whfyczcj	121	5	,	,	,
cord-260476-whfyczcj	121	6	we	-PRON-	PRP
cord-260476-whfyczcj	121	7	will	will	MD
cord-260476-whfyczcj	121	8	discuss	discuss	VB
cord-260476-whfyczcj	121	9	in	in	IN
cord-260476-whfyczcj	121	10	detail	detail	NN
cord-260476-whfyczcj	121	11	the	the	DT
cord-260476-whfyczcj	121	12	restriction	restriction	NN
cord-260476-whfyczcj	121	13	factors	factor	NNS
cord-260476-whfyczcj	121	14	as	as	RB
cord-260476-whfyczcj	121	15	well	well	RB
cord-260476-whfyczcj	121	16	as	as	IN
cord-260476-whfyczcj	121	17	the	the	DT
cord-260476-whfyczcj	121	18	viral	viral	JJ
cord-260476-whfyczcj	121	19	proteins	protein	NNS
cord-260476-whfyczcj	121	20	which	which	WDT
cord-260476-whfyczcj	121	21	use	use	VBP
cord-260476-whfyczcj	121	22	the	the	DT
cord-260476-whfyczcj	121	23	UPS	up	NNS
cord-260476-whfyczcj	121	24	for	for	IN
cord-260476-whfyczcj	121	25	their	-PRON-	PRP$
cord-260476-whfyczcj	121	26	respective	respective	JJ
cord-260476-whfyczcj	121	27	mechanisms	mechanism	NNS
cord-260476-whfyczcj	121	28	.	.	.
cord-260476-whfyczcj	121	29	 	 	_SP
cord-260476-whfyczcj	122	1	One	one	CD
cord-260476-whfyczcj	122	2	example	example	NN
cord-260476-whfyczcj	122	3	of	of	IN
cord-260476-whfyczcj	122	4	the	the	DT
cord-260476-whfyczcj	122	5	cell	cell	NN
cord-260476-whfyczcj	122	6	using	use	VBG
cord-260476-whfyczcj	122	7	the	the	DT
cord-260476-whfyczcj	122	8	UPS	UPS	NNPS
cord-260476-whfyczcj	122	9	to	to	TO
cord-260476-whfyczcj	122	10	restrict	restrict	VB
cord-260476-whfyczcj	122	11	HIV	HIV	NNP
cord-260476-whfyczcj	122	12	is	be	VBZ
cord-260476-whfyczcj	122	13	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	122	14	,	,	,
cord-260476-whfyczcj	122	15	an	an	DT
cord-260476-whfyczcj	122	16	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	122	17	ligase	ligase	NN
cord-260476-whfyczcj	122	18	that	that	WDT
cord-260476-whfyczcj	122	19	interacts	interact	VBZ
cord-260476-whfyczcj	122	20	with	with	IN
cord-260476-whfyczcj	122	21	the	the	DT
cord-260476-whfyczcj	122	22	viral	viral	JJ
cord-260476-whfyczcj	122	23	capsid	capsid	NN
cord-260476-whfyczcj	122	24	after	after	IN
cord-260476-whfyczcj	122	25	its	-PRON-	PRP$
cord-260476-whfyczcj	122	26	entry	entry	NN
cord-260476-whfyczcj	122	27	into	into	IN
cord-260476-whfyczcj	122	28	the	the	DT
cord-260476-whfyczcj	122	29	cell	cell	NN
cord-260476-whfyczcj	122	30	.	.	.
cord-260476-whfyczcj	123	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	123	2	mediates	mediate	VBZ
cord-260476-whfyczcj	123	3	a	a	DT
cord-260476-whfyczcj	123	4	species	species	NN
cord-260476-whfyczcj	123	5	-	-	HYPH
cord-260476-whfyczcj	123	6	specific	specific	JJ
cord-260476-whfyczcj	123	7	block	block	NN
cord-260476-whfyczcj	123	8	:	:	:
cord-260476-whfyczcj	123	9	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	123	10	is	be	VBZ
cord-260476-whfyczcj	123	11	restricted	restrict	VBN
cord-260476-whfyczcj	123	12	by	by	IN
cord-260476-whfyczcj	123	13	the	the	DT
cord-260476-whfyczcj	123	14	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	123	15	proteins	protein	NNS
cord-260476-whfyczcj	123	16	of	of	IN
cord-260476-whfyczcj	123	17	old	old	JJ
cord-260476-whfyczcj	123	18	world	world	NN
cord-260476-whfyczcj	123	19	monkeys	monkey	NNS
cord-260476-whfyczcj	123	20	like	like	IN
cord-260476-whfyczcj	123	21	rhesus	rhesu	NNS
cord-260476-whfyczcj	123	22	or	or	CC
cord-260476-whfyczcj	123	23	cynomolgous	cynomolgous	JJ
cord-260476-whfyczcj	123	24	 	 	_SP
cord-260476-whfyczcj	124	1	One	one	CD
cord-260476-whfyczcj	124	2	example	example	NN
cord-260476-whfyczcj	124	3	of	of	IN
cord-260476-whfyczcj	124	4	the	the	DT
cord-260476-whfyczcj	124	5	cell	cell	NN
cord-260476-whfyczcj	124	6	using	use	VBG
cord-260476-whfyczcj	124	7	the	the	DT
cord-260476-whfyczcj	124	8	UPS	UPS	NNPS
cord-260476-whfyczcj	124	9	to	to	TO
cord-260476-whfyczcj	124	10	restrict	restrict	VB
cord-260476-whfyczcj	124	11	HIV	HIV	NNP
cord-260476-whfyczcj	124	12	is	be	VBZ
cord-260476-whfyczcj	124	13	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	124	14	,	,	,
cord-260476-whfyczcj	124	15	an	an	DT
cord-260476-whfyczcj	124	16	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	124	17	ligase	ligase	NN
cord-260476-whfyczcj	124	18	that	that	WDT
cord-260476-whfyczcj	124	19	interacts	interact	VBZ
cord-260476-whfyczcj	124	20	with	with	IN
cord-260476-whfyczcj	124	21	the	the	DT
cord-260476-whfyczcj	124	22	viral	viral	JJ
cord-260476-whfyczcj	124	23	capsid	capsid	NN
cord-260476-whfyczcj	124	24	after	after	IN
cord-260476-whfyczcj	124	25	its	-PRON-	PRP$
cord-260476-whfyczcj	124	26	entry	entry	NN
cord-260476-whfyczcj	124	27	into	into	IN
cord-260476-whfyczcj	124	28	the	the	DT
cord-260476-whfyczcj	124	29	cell	cell	NN
cord-260476-whfyczcj	124	30	.	.	.
cord-260476-whfyczcj	125	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	125	2	mediates	mediate	VBZ
cord-260476-whfyczcj	125	3	a	a	DT
cord-260476-whfyczcj	125	4	species	species	NN
cord-260476-whfyczcj	125	5	-	-	HYPH
cord-260476-whfyczcj	125	6	specific	specific	JJ
cord-260476-whfyczcj	125	7	block	block	NN
cord-260476-whfyczcj	125	8	:	:	:
cord-260476-whfyczcj	125	9	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	125	10	is	be	VBZ
cord-260476-whfyczcj	125	11	restricted	restrict	VBN
cord-260476-whfyczcj	125	12	by	by	IN
cord-260476-whfyczcj	125	13	the	the	DT
cord-260476-whfyczcj	125	14	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	125	15	proteins	protein	NNS
cord-260476-whfyczcj	125	16	of	of	IN
cord-260476-whfyczcj	125	17	old	old	JJ
cord-260476-whfyczcj	125	18	world	world	NN
cord-260476-whfyczcj	125	19	monkeys	monkey	NNS
cord-260476-whfyczcj	125	20	like	like	IN
cord-260476-whfyczcj	125	21	rhesus	rhesu	NNS
cord-260476-whfyczcj	125	22	or	or	CC
cord-260476-whfyczcj	125	23	cynomolgous	cynomolgous	JJ
cord-260476-whfyczcj	125	24	monkeys	monkey	NNS
cord-260476-whfyczcj	125	25	,	,	,
cord-260476-whfyczcj	125	26	while	while	IN
cord-260476-whfyczcj	125	27	the	the	DT
cord-260476-whfyczcj	125	28	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	125	29	of	of	IN
cord-260476-whfyczcj	125	30	human	human	JJ
cord-260476-whfyczcj	125	31	or	or	CC
cord-260476-whfyczcj	125	32	new	new	JJ
cord-260476-whfyczcj	125	33	world	world	NN
cord-260476-whfyczcj	125	34	monkeys	monkey	NNS
cord-260476-whfyczcj	125	35	have	have	VBP
cord-260476-whfyczcj	125	36	no	no	DT
cord-260476-whfyczcj	125	37	or	or	CC
cord-260476-whfyczcj	125	38	only	only	RB
cord-260476-whfyczcj	125	39	a	a	DT
cord-260476-whfyczcj	125	40	very	very	RB
cord-260476-whfyczcj	125	41	weak	weak	JJ
cord-260476-whfyczcj	125	42	effect	effect	NN
cord-260476-whfyczcj	125	43	on	on	IN
cord-260476-whfyczcj	125	44	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	125	45	[	[	-LRB-
cord-260476-whfyczcj	125	46	59	59	CD
cord-260476-whfyczcj	125	47	,	,	,
cord-260476-whfyczcj	125	48	60	60	CD
cord-260476-whfyczcj	125	49	,	,	,
cord-260476-whfyczcj	125	50	86	86	CD
cord-260476-whfyczcj	125	51	,	,	,
cord-260476-whfyczcj	125	52	87	87	CD
cord-260476-whfyczcj	125	53	]	]	-RRB-
cord-260476-whfyczcj	125	54	.	.	.
cord-260476-whfyczcj	126	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	126	2	thereby	thereby	RB
cord-260476-whfyczcj	126	3	constitutes	constitute	VBZ
cord-260476-whfyczcj	126	4	one	one	CD
cord-260476-whfyczcj	126	5	of	of	IN
cord-260476-whfyczcj	126	6	the	the	DT
cord-260476-whfyczcj	126	7	factors	factor	NNS
cord-260476-whfyczcj	126	8	responsible	responsible	JJ
cord-260476-whfyczcj	126	9	for	for	IN
cord-260476-whfyczcj	126	10	the	the	DT
cord-260476-whfyczcj	126	11	interspecies	interspecie	NNS
cord-260476-whfyczcj	126	12	barrier	barrier	NN
cord-260476-whfyczcj	126	13	.	.	.
cord-260476-whfyczcj	127	1	The	the	DT
cord-260476-whfyczcj	127	2	restriction	restriction	NN
cord-260476-whfyczcj	127	3	of	of	IN
cord-260476-whfyczcj	127	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	127	5	by	by	IN
cord-260476-whfyczcj	127	6	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	127	7	is	be	VBZ
cord-260476-whfyczcj	127	8	mediated	mediate	VBN
cord-260476-whfyczcj	127	9	by	by	IN
cord-260476-whfyczcj	127	10	the	the	DT
cord-260476-whfyczcj	127	11	interaction	interaction	NN
cord-260476-whfyczcj	127	12	of	of	IN
cord-260476-whfyczcj	127	13	the	the	DT
cord-260476-whfyczcj	127	14	TRIM5α	trim5α	JJ
cord-260476-whfyczcj	127	15	SPRY	SPRY	NNP
cord-260476-whfyczcj	127	16	(	(	-LRB-
cord-260476-whfyczcj	127	17	SPIa	SPIa	NNS
cord-260476-whfyczcj	127	18	and	and	CC
cord-260476-whfyczcj	127	19	RYanodine	ryanodine	JJ
cord-260476-whfyczcj	127	20	Receptor	receptor	NN
cord-260476-whfyczcj	127	21	)	)	-RRB-
cord-260476-whfyczcj	127	22	domain	domain	NN
cord-260476-whfyczcj	127	23	(	(	-LRB-
cord-260476-whfyczcj	127	24	Figure	figure	NN
cord-260476-whfyczcj	127	25	3A	3a	CD
cord-260476-whfyczcj	127	26	)	)	-RRB-
cord-260476-whfyczcj	127	27	with	with	IN
cord-260476-whfyczcj	127	28	the	the	DT
cord-260476-whfyczcj	127	29	viral	viral	JJ
cord-260476-whfyczcj	127	30	capsid	capsid	NN
cord-260476-whfyczcj	127	31	in	in	IN
cord-260476-whfyczcj	127	32	the	the	DT
cord-260476-whfyczcj	127	33	cytoplasm	cytoplasm	NN
cord-260476-whfyczcj	127	34	of	of	IN
cord-260476-whfyczcj	127	35	newly	newly	RB
cord-260476-whfyczcj	127	36	infected	infect	VBN
cord-260476-whfyczcj	127	37	cells	cell	NNS
cord-260476-whfyczcj	127	38	[	[	-LRB-
cord-260476-whfyczcj	127	39	59	59	CD
cord-260476-whfyczcj	127	40	]	]	-RRB-
cord-260476-whfyczcj	127	41	.	.	.
cord-260476-whfyczcj	128	1	This	this	DT
cord-260476-whfyczcj	128	2	interaction	interaction	NN
cord-260476-whfyczcj	128	3	leads	lead	VBZ
cord-260476-whfyczcj	128	4	to	to	IN
cord-260476-whfyczcj	128	5	premature	premature	JJ
cord-260476-whfyczcj	128	6	decapsidation	decapsidation	NN
cord-260476-whfyczcj	128	7	of	of	IN
cord-260476-whfyczcj	128	8	the	the	DT
cord-260476-whfyczcj	128	9	viral	viral	JJ
cord-260476-whfyczcj	128	10	core	core	NN
cord-260476-whfyczcj	128	11	.	.	.
cord-260476-whfyczcj	129	1	Moreover	moreover	RB
cord-260476-whfyczcj	129	2	,	,	,
cord-260476-whfyczcj	129	3	viral	viral	JJ
cord-260476-whfyczcj	129	4	capsid	capsid	NN
cord-260476-whfyczcj	129	5	and	and	CC
cord-260476-whfyczcj	129	6	integrase	integrase	NN
cord-260476-whfyczcj	129	7	proteins	protein	NNS
cord-260476-whfyczcj	129	8	are	be	VBP
cord-260476-whfyczcj	129	9	degraded	degrade	VBN
cord-260476-whfyczcj	129	10	(	(	-LRB-
cord-260476-whfyczcj	129	11	Figure	figure	NN
cord-260476-whfyczcj	129	12	3C	3c	NN
cord-260476-whfyczcj	129	13	1	1	CD
cord-260476-whfyczcj	129	14	)	)	-RRB-
cord-260476-whfyczcj	129	15	and	and	CC
cord-260476-whfyczcj	129	16	the	the	DT
cord-260476-whfyczcj	129	17	reverse	reverse	JJ
cord-260476-whfyczcj	129	18	transcription	transcription	NN
cord-260476-whfyczcj	129	19	of	of	IN
cord-260476-whfyczcj	129	20	the	the	DT
cord-260476-whfyczcj	129	21	viral	viral	JJ
cord-260476-whfyczcj	129	22	genome	genome	NN
cord-260476-whfyczcj	129	23	is	be	VBZ
cord-260476-whfyczcj	129	24	inhibited	inhibit	VBN
cord-260476-whfyczcj	129	25	in	in	IN
cord-260476-whfyczcj	129	26	the	the	DT
cord-260476-whfyczcj	129	27	presence	presence	NN
cord-260476-whfyczcj	129	28	of	of	IN
cord-260476-whfyczcj	129	29	a	a	DT
cord-260476-whfyczcj	129	30	restricting	restrict	VBG
cord-260476-whfyczcj	129	31	TRIM5α	trim5α	NN
cord-260476-whfyczcj	129	32	.	.	.
cord-260476-whfyczcj	130	1	These	these	DT
cord-260476-whfyczcj	130	2	effects	effect	NNS
cord-260476-whfyczcj	130	3	seem	seem	VBP
cord-260476-whfyczcj	130	4	to	to	TO
cord-260476-whfyczcj	130	5	be	be	VB
cord-260476-whfyczcj	130	6	mediated	mediate	VBN
cord-260476-whfyczcj	130	7	by	by	IN
cord-260476-whfyczcj	130	8	the	the	DT
cord-260476-whfyczcj	130	9	UPS	UPS	NNPS
cord-260476-whfyczcj	130	10	,	,	,
cord-260476-whfyczcj	130	11	since	since	IN
cord-260476-whfyczcj	130	12	treatment	treatment	NN
cord-260476-whfyczcj	130	13	with	with	IN
cord-260476-whfyczcj	130	14	proteasome	proteasome	NN
cord-260476-whfyczcj	130	15	inhibitors	inhibitor	NNS
cord-260476-whfyczcj	130	16	restores	restore	VBZ
cord-260476-whfyczcj	130	17	a	a	DT
cord-260476-whfyczcj	130	18	normal	normal	JJ
cord-260476-whfyczcj	130	19	decapsidation	decapsidation	NN
cord-260476-whfyczcj	130	20	rate	rate	NN
cord-260476-whfyczcj	130	21	and	and	CC
cord-260476-whfyczcj	130	22	reverse	reverse	VB
cord-260476-whfyczcj	130	23	transcription	transcription	NN
cord-260476-whfyczcj	130	24	.	.	.
cord-260476-whfyczcj	131	1	It	-PRON-	PRP
cord-260476-whfyczcj	131	2	has	have	VBZ
cord-260476-whfyczcj	131	3	also	also	RB
cord-260476-whfyczcj	131	4	been	be	VBN
cord-260476-whfyczcj	131	5	shown	show	VBN
cord-260476-whfyczcj	131	6	that	that	IN
cord-260476-whfyczcj	131	7	the	the	DT
cord-260476-whfyczcj	131	8	proteasome	proteasome	NN
cord-260476-whfyczcj	131	9	co	co	NN
cord-260476-whfyczcj	131	10	-	-	NN
cord-260476-whfyczcj	131	11	localizes	localize	VBZ
cord-260476-whfyczcj	131	12	with	with	IN
cord-260476-whfyczcj	131	13	TRIM5α	trim5α	JJ
cord-260476-whfyczcj	131	14	and	and	CC
cord-260476-whfyczcj	131	15	viral	viral	JJ
cord-260476-whfyczcj	131	16	cores	core	NNS
cord-260476-whfyczcj	131	17	in	in	IN
cord-260476-whfyczcj	131	18	the	the	DT
cord-260476-whfyczcj	131	19	cytoplasm	cytoplasm	NN
cord-260476-whfyczcj	131	20	[	[	-LRB-
cord-260476-whfyczcj	131	21	88	88	CD
cord-260476-whfyczcj	131	22	,	,	,
cord-260476-whfyczcj	131	23	89	89	CD
cord-260476-whfyczcj	131	24	]	]	-RRB-
cord-260476-whfyczcj	131	25	.	.	.
cord-260476-whfyczcj	132	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	132	2	is	be	VBZ
cord-260476-whfyczcj	132	3	also	also	RB
cord-260476-whfyczcj	132	4	degraded	degrade	VBN
cord-260476-whfyczcj	132	5	by	by	IN
cord-260476-whfyczcj	132	6	the	the	DT
cord-260476-whfyczcj	132	7	proteasome	proteasome	NN
cord-260476-whfyczcj	132	8	but	but	CC
cord-260476-whfyczcj	132	9	only	only	RB
cord-260476-whfyczcj	132	10	in	in	IN
cord-260476-whfyczcj	132	11	the	the	DT
cord-260476-whfyczcj	132	12	presence	presence	NN
cord-260476-whfyczcj	132	13	of	of	IN
cord-260476-whfyczcj	132	14	susceptible	susceptible	JJ
cord-260476-whfyczcj	132	15	viral	viral	JJ
cord-260476-whfyczcj	132	16	cores	core	NNS
cord-260476-whfyczcj	132	17	[	[	-LRB-
cord-260476-whfyczcj	132	18	90	90	CD
cord-260476-whfyczcj	132	19	]	]	-RRB-
cord-260476-whfyczcj	132	20	,	,	,
cord-260476-whfyczcj	132	21	suggesting	suggest	VBG
cord-260476-whfyczcj	132	22	that	that	IN
cord-260476-whfyczcj	132	23	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	132	24	recruits	recruit	VBZ
cord-260476-whfyczcj	132	25	the	the	DT
cord-260476-whfyczcj	132	26	proteasome	proteasome	NN
cord-260476-whfyczcj	132	27	to	to	IN
cord-260476-whfyczcj	132	28	the	the	DT
cord-260476-whfyczcj	132	29	viral	viral	JJ
cord-260476-whfyczcj	132	30	cores	core	NNS
cord-260476-whfyczcj	132	31	and	and	CC
cord-260476-whfyczcj	132	32	induces	induce	VBZ
cord-260476-whfyczcj	132	33	their	-PRON-	PRP$
cord-260476-whfyczcj	132	34	degradation	degradation	NN
cord-260476-whfyczcj	132	35	.	.	.
cord-260476-whfyczcj	133	1	This	this	DT
cord-260476-whfyczcj	133	2	mechanism	mechanism	NN
cord-260476-whfyczcj	133	3	seems	seem	VBZ
cord-260476-whfyczcj	133	4	to	to	TO
cord-260476-whfyczcj	133	5	be	be	VB
cord-260476-whfyczcj	133	6	mediated	mediate	VBN
cord-260476-whfyczcj	133	7	by	by	IN
cord-260476-whfyczcj	133	8	the	the	DT
cord-260476-whfyczcj	133	9	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	133	10	ligase	ligase	NN
cord-260476-whfyczcj	133	11	activity	activity	NN
cord-260476-whfyczcj	133	12	of	of	IN
cord-260476-whfyczcj	133	13	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	133	14	,	,	,
cord-260476-whfyczcj	133	15	through	through	IN
cord-260476-whfyczcj	133	16	its	-PRON-	PRP$
cord-260476-whfyczcj	133	17	RING	ring	NN
cord-260476-whfyczcj	133	18	domain	domain	NN
cord-260476-whfyczcj	133	19	(	(	-LRB-
cord-260476-whfyczcj	133	20	Figure	figure	NN
cord-260476-whfyczcj	133	21	3A	3a	CD
cord-260476-whfyczcj	133	22	)	)	-RRB-
cord-260476-whfyczcj	133	23	[	[	-LRB-
cord-260476-whfyczcj	133	24	58	58	CD
cord-260476-whfyczcj	133	25	,	,	,
cord-260476-whfyczcj	133	26	91	91	CD
cord-260476-whfyczcj	133	27	]	]	-RRB-
cord-260476-whfyczcj	133	28	.	.	.
cord-260476-whfyczcj	134	1	Nevertheless	nevertheless	RB
cord-260476-whfyczcj	134	2	,	,	,
cord-260476-whfyczcj	134	3	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	134	4	inhibits	inhibit	VBZ
cord-260476-whfyczcj	134	5	integration	integration	NN
cord-260476-whfyczcj	134	6	of	of	IN
cord-260476-whfyczcj	134	7	the	the	DT
cord-260476-whfyczcj	134	8	proviral	proviral	JJ
cord-260476-whfyczcj	134	9	DNA	DNA	NNP
cord-260476-whfyczcj	134	10	independently	independently	RB
cord-260476-whfyczcj	134	11	of	of	IN
cord-260476-whfyczcj	134	12	the	the	DT
cord-260476-whfyczcj	134	13	proteasome	proteasome	NN
cord-260476-whfyczcj	134	14	,	,	,
cord-260476-whfyczcj	134	15	suggesting	suggest	VBG
cord-260476-whfyczcj	134	16	that	that	IN
cord-260476-whfyczcj	134	17	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	134	18	uses	use	VBZ
cord-260476-whfyczcj	134	19	an	an	DT
cord-260476-whfyczcj	134	20	additional	additional	JJ
cord-260476-whfyczcj	134	21	,	,	,
cord-260476-whfyczcj	134	22	yet	yet	CC
cord-260476-whfyczcj	134	23	uncharacterized	uncharacterized	JJ
cord-260476-whfyczcj	134	24	,	,	,
cord-260476-whfyczcj	134	25	strategy	strategy	NN
cord-260476-whfyczcj	134	26	to	to	TO
cord-260476-whfyczcj	134	27	block	block	VB
cord-260476-whfyczcj	134	28	viral	viral	JJ
cord-260476-whfyczcj	134	29	infection	infection	NN
cord-260476-whfyczcj	134	30	(	(	-LRB-
cord-260476-whfyczcj	134	31	Figure	figure	NN
cord-260476-whfyczcj	134	32	3C	3c	NN
cord-260476-whfyczcj	134	33	2	2	CD
cord-260476-whfyczcj	134	34	)	)	-RRB-
cord-260476-whfyczcj	134	35	[	[	-LRB-
cord-260476-whfyczcj	134	36	92	92	CD
cord-260476-whfyczcj	134	37	,	,	,
cord-260476-whfyczcj	134	38	93	93	CD
cord-260476-whfyczcj	134	39	]	]	-RRB-
cord-260476-whfyczcj	134	40	.	.	.
cord-260476-whfyczcj	135	1	Finally	finally	RB
cord-260476-whfyczcj	135	2	,	,	,
cord-260476-whfyczcj	135	3	the	the	DT
cord-260476-whfyczcj	135	4	association	association	NN
cord-260476-whfyczcj	135	5	of	of	IN
cord-260476-whfyczcj	135	6	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	135	7	with	with	IN
cord-260476-whfyczcj	135	8	the	the	DT
cord-260476-whfyczcj	135	9	viral	viral	JJ
cord-260476-whfyczcj	135	10	capsid	capsid	NN
cord-260476-whfyczcj	135	11	enhances	enhance	VBZ
cord-260476-whfyczcj	135	12	its	-PRON-	PRP$
cord-260476-whfyczcj	135	13	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	135	14	ligase	ligase	NN
cord-260476-whfyczcj	135	15	activity	activity	NN
cord-260476-whfyczcj	135	16	,	,	,
cord-260476-whfyczcj	135	17	which	which	WDT
cord-260476-whfyczcj	135	18	,	,	,
cord-260476-whfyczcj	135	19	in	in	IN
cord-260476-whfyczcj	135	20	conjunction	conjunction	NN
cord-260476-whfyczcj	135	21	with	with	IN
cord-260476-whfyczcj	135	22	the	the	DT
cord-260476-whfyczcj	135	23	E2	E2	NNP
cord-260476-whfyczcj	135	24	enzyme	enzyme	NN
cord-260476-whfyczcj	135	25	UBC13	UBC13	NNP
cord-260476-whfyczcj	135	26	/	/	SYM
cord-260476-whfyczcj	135	27	UEV1A	UEV1A	.
cord-260476-whfyczcj	136	1	(	(	-LRB-
cord-260476-whfyczcj	136	2	UBiquitin	UBiquitin	NNP
cord-260476-whfyczcj	136	3	-	-	HYPH
cord-260476-whfyczcj	136	4	Conjugating	Conjugating	NNP
cord-260476-whfyczcj	136	5	enzyme	enzyme	NN
cord-260476-whfyczcj	136	6	13	13	CD
cord-260476-whfyczcj	136	7	/	/	SYM
cord-260476-whfyczcj	136	8	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	136	9	-	-	HYPH
cord-260476-whfyczcj	136	10	conjugating	conjugate	VBG
cord-260476-whfyczcj	136	11	Enzyme	Enzyme	NNP
cord-260476-whfyczcj	136	12	Variant	Variant	NNP
cord-260476-whfyczcj	136	13	1A	1a	NN
cord-260476-whfyczcj	136	14	)	)	-RRB-
cord-260476-whfyczcj	136	15	,	,	,
cord-260476-whfyczcj	136	16	leads	lead	VBZ
cord-260476-whfyczcj	136	17	to	to	IN
cord-260476-whfyczcj	136	18	the	the	DT
cord-260476-whfyczcj	136	19	synthesis	synthesis	NN
cord-260476-whfyczcj	136	20	of	of	IN
cord-260476-whfyczcj	136	21	free	free	JJ
cord-260476-whfyczcj	136	22	K63-linked	K63-linked	NNP
cord-260476-whfyczcj	136	23	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	136	24	chains	chain	NNS
cord-260476-whfyczcj	136	25	,	,	,
cord-260476-whfyczcj	136	26	thus	thus	RB
cord-260476-whfyczcj	136	27	stimulating	stimulate	VBG
cord-260476-whfyczcj	136	28	TAK1	TAK1	NNP
cord-260476-whfyczcj	136	29	(	(	-LRB-
cord-260476-whfyczcj	136	30	Transforming	transform	VBG
cord-260476-whfyczcj	136	31	growth	growth	NN
cord-260476-whfyczcj	136	32	factor	factor	NN
cord-260476-whfyczcj	136	33	β	β	NN
cord-260476-whfyczcj	136	34	-	-	HYPH
cord-260476-whfyczcj	136	35	Activated	activate	VBN
cord-260476-whfyczcj	136	36	Kinase	Kinase	NNP
cord-260476-whfyczcj	136	37	1	1	CD
cord-260476-whfyczcj	136	38	)	)	-RRB-
cord-260476-whfyczcj	136	39	and	and	CC
cord-260476-whfyczcj	136	40	finally	finally	RB
cord-260476-whfyczcj	136	41	activating	activate	VBG
cord-260476-whfyczcj	136	42	AP1	ap1	NN
cord-260476-whfyczcj	136	43	and	and	CC
cord-260476-whfyczcj	136	44	NF	NF	NNP
cord-260476-whfyczcj	136	45	-	-	HYPH
cord-260476-whfyczcj	136	46	κB	κB	NNP
cord-260476-whfyczcj	136	47	signaling	signal	VBG
cord-260476-whfyczcj	136	48	(	(	-LRB-
cord-260476-whfyczcj	136	49	Figure	figure	NN
cord-260476-whfyczcj	136	50	3C	3C	NNP
cord-260476-whfyczcj	136	51	3	3	CD
cord-260476-whfyczcj	136	52	)	)	-RRB-
cord-260476-whfyczcj	136	53	[	[	-LRB-
cord-260476-whfyczcj	136	54	94	94	CD
cord-260476-whfyczcj	136	55	,	,	,
cord-260476-whfyczcj	136	56	95	95	CD
cord-260476-whfyczcj	136	57	]	]	-RRB-
cord-260476-whfyczcj	136	58	.	.	.
cord-260476-whfyczcj	137	1	This	this	DT
cord-260476-whfyczcj	137	2	indicates	indicate	VBZ
cord-260476-whfyczcj	137	3	that	that	IN
cord-260476-whfyczcj	137	4	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	137	5	,	,	,
cord-260476-whfyczcj	137	6	in	in	IN
cord-260476-whfyczcj	137	7	addition	addition	NN
cord-260476-whfyczcj	137	8	to	to	IN
cord-260476-whfyczcj	137	9	its	-PRON-	PRP$
cord-260476-whfyczcj	137	10	direct	direct	JJ
cord-260476-whfyczcj	137	11	antiviral	antiviral	JJ
cord-260476-whfyczcj	137	12	activity	activity	NN
cord-260476-whfyczcj	137	13	,	,	,
cord-260476-whfyczcj	137	14	also	also	RB
cord-260476-whfyczcj	137	15	functions	function	VBZ
cord-260476-whfyczcj	137	16	as	as	IN
cord-260476-whfyczcj	137	17	a	a	DT
cord-260476-whfyczcj	137	18	sensor	sensor	NN
cord-260476-whfyczcj	137	19	that	that	WDT
cord-260476-whfyczcj	137	20	induces	induce	VBZ
cord-260476-whfyczcj	137	21	a	a	DT
cord-260476-whfyczcj	137	22	general	general	JJ
cord-260476-whfyczcj	137	23	antiviral	antiviral	JJ
cord-260476-whfyczcj	137	24	state	state	NN
cord-260476-whfyczcj	137	25	of	of	IN
cord-260476-whfyczcj	137	26	the	the	DT
cord-260476-whfyczcj	137	27	cell	cell	NN
cord-260476-whfyczcj	137	28	.	.	.
cord-260476-whfyczcj	138	1	Figure	figure	NN
cord-260476-whfyczcj	138	2	3A	3a	CD
cord-260476-whfyczcj	138	3	)	)	-RRB-
cord-260476-whfyczcj	138	4	with	with	IN
cord-260476-whfyczcj	138	5	the	the	DT
cord-260476-whfyczcj	138	6	viral	viral	JJ
cord-260476-whfyczcj	138	7	capsid	capsid	NN
cord-260476-whfyczcj	138	8	in	in	IN
cord-260476-whfyczcj	138	9	the	the	DT
cord-260476-whfyczcj	138	10	cytoplasm	cytoplasm	NN
cord-260476-whfyczcj	138	11	of	of	IN
cord-260476-whfyczcj	138	12	newly	newly	RB
cord-260476-whfyczcj	138	13	infected	infect	VBN
cord-260476-whfyczcj	138	14	cells	cell	NNS
cord-260476-whfyczcj	138	15	[	[	-LRB-
cord-260476-whfyczcj	138	16	59	59	CD
cord-260476-whfyczcj	138	17	]	]	-RRB-
cord-260476-whfyczcj	138	18	.	.	.
cord-260476-whfyczcj	139	1	This	this	DT
cord-260476-whfyczcj	139	2	interaction	interaction	NN
cord-260476-whfyczcj	139	3	leads	lead	VBZ
cord-260476-whfyczcj	139	4	to	to	IN
cord-260476-whfyczcj	139	5	premature	premature	JJ
cord-260476-whfyczcj	139	6	decapsidation	decapsidation	NN
cord-260476-whfyczcj	139	7	of	of	IN
cord-260476-whfyczcj	139	8	the	the	DT
cord-260476-whfyczcj	139	9	viral	viral	JJ
cord-260476-whfyczcj	139	10	core	core	NN
cord-260476-whfyczcj	139	11	.	.	.
cord-260476-whfyczcj	140	1	Moreover	moreover	RB
cord-260476-whfyczcj	140	2	,	,	,
cord-260476-whfyczcj	140	3	viral	viral	JJ
cord-260476-whfyczcj	140	4	capsid	capsid	NN
cord-260476-whfyczcj	140	5	and	and	CC
cord-260476-whfyczcj	140	6	integrase	integrase	NN
cord-260476-whfyczcj	140	7	proteins	protein	NNS
cord-260476-whfyczcj	140	8	are	be	VBP
cord-260476-whfyczcj	140	9	degraded	degrade	VBN
cord-260476-whfyczcj	140	10	(	(	-LRB-
cord-260476-whfyczcj	140	11	Figure	Figure	NNP
cord-260476-whfyczcj	140	12	3C	3c	NN
cord-260476-whfyczcj	140	13	)	)	-RRB-
cord-260476-whfyczcj	140	14	and	and	CC
cord-260476-whfyczcj	140	15	the	the	DT
cord-260476-whfyczcj	140	16	reverse	reverse	JJ
cord-260476-whfyczcj	140	17	transcription	transcription	NN
cord-260476-whfyczcj	140	18	of	of	IN
cord-260476-whfyczcj	140	19	the	the	DT
cord-260476-whfyczcj	140	20	viral	viral	JJ
cord-260476-whfyczcj	140	21	genome	genome	NN
cord-260476-whfyczcj	140	22	is	be	VBZ
cord-260476-whfyczcj	140	23	inhibited	inhibit	VBN
cord-260476-whfyczcj	140	24	in	in	IN
cord-260476-whfyczcj	140	25	the	the	DT
cord-260476-whfyczcj	140	26	presence	presence	NN
cord-260476-whfyczcj	140	27	of	of	IN
cord-260476-whfyczcj	140	28	a	a	DT
cord-260476-whfyczcj	140	29	restricting	restrict	VBG
cord-260476-whfyczcj	140	30	TRIM5α	trim5α	NN
cord-260476-whfyczcj	140	31	.	.	.
cord-260476-whfyczcj	141	1	These	these	DT
cord-260476-whfyczcj	141	2	effects	effect	NNS
cord-260476-whfyczcj	141	3	seem	seem	VBP
cord-260476-whfyczcj	141	4	to	to	TO
cord-260476-whfyczcj	141	5	be	be	VB
cord-260476-whfyczcj	141	6	mediated	mediate	VBN
cord-260476-whfyczcj	141	7	by	by	IN
cord-260476-whfyczcj	141	8	the	the	DT
cord-260476-whfyczcj	141	9	UPS	UPS	NNPS
cord-260476-whfyczcj	141	10	,	,	,
cord-260476-whfyczcj	141	11	since	since	IN
cord-260476-whfyczcj	141	12	treatment	treatment	NN
cord-260476-whfyczcj	141	13	with	with	IN
cord-260476-whfyczcj	141	14	proteasome	proteasome	NN
cord-260476-whfyczcj	141	15	inhibitors	inhibitor	NNS
cord-260476-whfyczcj	141	16	restores	restore	VBZ
cord-260476-whfyczcj	141	17	a	a	DT
cord-260476-whfyczcj	141	18	normal	normal	JJ
cord-260476-whfyczcj	141	19	decapsidation	decapsidation	NN
cord-260476-whfyczcj	141	20	rate	rate	NN
cord-260476-whfyczcj	141	21	and	and	CC
cord-260476-whfyczcj	141	22	reverse	reverse	VB
cord-260476-whfyczcj	141	23	transcription	transcription	NN
cord-260476-whfyczcj	141	24	.	.	.
cord-260476-whfyczcj	142	1	It	-PRON-	PRP
cord-260476-whfyczcj	142	2	has	have	VBZ
cord-260476-whfyczcj	142	3	also	also	RB
cord-260476-whfyczcj	142	4	been	be	VBN
cord-260476-whfyczcj	142	5	shown	show	VBN
cord-260476-whfyczcj	142	6	that	that	IN
cord-260476-whfyczcj	142	7	the	the	DT
cord-260476-whfyczcj	142	8	proteasome	proteasome	NN
cord-260476-whfyczcj	142	9	co	co	NN
cord-260476-whfyczcj	142	10	-	-	NN
cord-260476-whfyczcj	142	11	localizes	localize	VBZ
cord-260476-whfyczcj	142	12	with	with	IN
cord-260476-whfyczcj	142	13	TRIM5α	trim5α	JJ
cord-260476-whfyczcj	142	14	and	and	CC
cord-260476-whfyczcj	142	15	viral	viral	JJ
cord-260476-whfyczcj	142	16	cores	core	NNS
cord-260476-whfyczcj	142	17	in	in	IN
cord-260476-whfyczcj	142	18	the	the	DT
cord-260476-whfyczcj	142	19	cytoplasm	cytoplasm	NN
cord-260476-whfyczcj	142	20	[	[	-LRB-
cord-260476-whfyczcj	142	21	88	88	CD
cord-260476-whfyczcj	142	22	,	,	,
cord-260476-whfyczcj	142	23	89	89	CD
cord-260476-whfyczcj	142	24	]	]	-RRB-
cord-260476-whfyczcj	142	25	.	.	.
cord-260476-whfyczcj	143	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	143	2	is	be	VBZ
cord-260476-whfyczcj	143	3	also	also	RB
cord-260476-whfyczcj	143	4	degraded	degrade	VBN
cord-260476-whfyczcj	143	5	by	by	IN
cord-260476-whfyczcj	143	6	the	the	DT
cord-260476-whfyczcj	143	7	proteasome	proteasome	NN
cord-260476-whfyczcj	143	8	but	but	CC
cord-260476-whfyczcj	143	9	only	only	RB
cord-260476-whfyczcj	143	10	in	in	IN
cord-260476-whfyczcj	143	11	the	the	DT
cord-260476-whfyczcj	143	12	presence	presence	NN
cord-260476-whfyczcj	143	13	of	of	IN
cord-260476-whfyczcj	143	14	susceptible	susceptible	JJ
cord-260476-whfyczcj	143	15	viral	viral	JJ
cord-260476-whfyczcj	143	16	cores	core	NNS
cord-260476-whfyczcj	143	17	[	[	-LRB-
cord-260476-whfyczcj	143	18	90	90	CD
cord-260476-whfyczcj	143	19	]	]	-RRB-
cord-260476-whfyczcj	143	20	,	,	,
cord-260476-whfyczcj	143	21	suggesting	suggest	VBG
cord-260476-whfyczcj	143	22	that	that	IN
cord-260476-whfyczcj	143	23	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	143	24	recruits	recruit	VBZ
cord-260476-whfyczcj	143	25	the	the	DT
cord-260476-whfyczcj	143	26	proteasome	proteasome	NN
cord-260476-whfyczcj	143	27	to	to	IN
cord-260476-whfyczcj	143	28	the	the	DT
cord-260476-whfyczcj	143	29	viral	viral	JJ
cord-260476-whfyczcj	143	30	cores	core	NNS
cord-260476-whfyczcj	143	31	and	and	CC
cord-260476-whfyczcj	143	32	induces	induce	VBZ
cord-260476-whfyczcj	143	33	their	-PRON-	PRP$
cord-260476-whfyczcj	143	34	degradation	degradation	NN
cord-260476-whfyczcj	143	35	.	.	.
cord-260476-whfyczcj	144	1	This	this	DT
cord-260476-whfyczcj	144	2	mechanism	mechanism	NN
cord-260476-whfyczcj	144	3	seems	seem	VBZ
cord-260476-whfyczcj	144	4	to	to	TO
cord-260476-whfyczcj	144	5	be	be	VB
cord-260476-whfyczcj	144	6	mediated	mediate	VBN
cord-260476-whfyczcj	144	7	by	by	IN
cord-260476-whfyczcj	144	8	the	the	DT
cord-260476-whfyczcj	144	9	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	144	10	ligase	ligase	NN
cord-260476-whfyczcj	144	11	activity	activity	NN
cord-260476-whfyczcj	144	12	of	of	IN
cord-260476-whfyczcj	144	13	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	144	14	,	,	,
cord-260476-whfyczcj	144	15	through	through	IN
cord-260476-whfyczcj	144	16	its	-PRON-	PRP$
cord-260476-whfyczcj	144	17	RING	ring	NN
cord-260476-whfyczcj	144	18	domain	domain	NN
cord-260476-whfyczcj	144	19	(	(	-LRB-
cord-260476-whfyczcj	144	20	Figure	figure	NN
cord-260476-whfyczcj	144	21	3A	3a	CD
cord-260476-whfyczcj	144	22	)	)	-RRB-
cord-260476-whfyczcj	144	23	[	[	-LRB-
cord-260476-whfyczcj	144	24	58	58	CD
cord-260476-whfyczcj	144	25	,	,	,
cord-260476-whfyczcj	144	26	91	91	CD
cord-260476-whfyczcj	144	27	]	]	-RRB-
cord-260476-whfyczcj	144	28	.	.	.
cord-260476-whfyczcj	145	1	Nevertheless	nevertheless	RB
cord-260476-whfyczcj	145	2	,	,	,
cord-260476-whfyczcj	145	3	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	145	4	inhibits	inhibit	VBZ
cord-260476-whfyczcj	145	5	integration	integration	NN
cord-260476-whfyczcj	145	6	of	of	IN
cord-260476-whfyczcj	145	7	the	the	DT
cord-260476-whfyczcj	145	8	proviral	proviral	JJ
cord-260476-whfyczcj	145	9	DNA	DNA	NNP
cord-260476-whfyczcj	145	10	independently	independently	RB
cord-260476-whfyczcj	145	11	of	of	IN
cord-260476-whfyczcj	145	12	the	the	DT
cord-260476-whfyczcj	145	13	proteasome	proteasome	NN
cord-260476-whfyczcj	145	14	,	,	,
cord-260476-whfyczcj	145	15	suggesting	suggest	VBG
cord-260476-whfyczcj	145	16	that	that	IN
cord-260476-whfyczcj	145	17	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	145	18	uses	use	VBZ
cord-260476-whfyczcj	145	19	an	an	DT
cord-260476-whfyczcj	145	20	additional	additional	JJ
cord-260476-whfyczcj	145	21	,	,	,
cord-260476-whfyczcj	145	22	yet	yet	CC
cord-260476-whfyczcj	145	23	uncharacterized	uncharacterized	JJ
cord-260476-whfyczcj	145	24	,	,	,
cord-260476-whfyczcj	145	25	strategy	strategy	NN
cord-260476-whfyczcj	145	26	to	to	TO
cord-260476-whfyczcj	145	27	block	block	VB
cord-260476-whfyczcj	145	28	viral	viral	JJ
cord-260476-whfyczcj	145	29	infection	infection	NN
cord-260476-whfyczcj	145	30	(	(	-LRB-
cord-260476-whfyczcj	145	31	Figure	figure	NN
cord-260476-whfyczcj	145	32	3C	3c	NN
cord-260476-whfyczcj	145	33	)	)	-RRB-
cord-260476-whfyczcj	145	34	[	[	-LRB-
cord-260476-whfyczcj	145	35	92	92	CD
cord-260476-whfyczcj	145	36	,	,	,
cord-260476-whfyczcj	145	37	93	93	CD
cord-260476-whfyczcj	145	38	]	]	-RRB-
cord-260476-whfyczcj	145	39	.	.	.
cord-260476-whfyczcj	146	1	Finally	finally	RB
cord-260476-whfyczcj	146	2	,	,	,
cord-260476-whfyczcj	146	3	the	the	DT
cord-260476-whfyczcj	146	4	association	association	NN
cord-260476-whfyczcj	146	5	of	of	IN
cord-260476-whfyczcj	146	6	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	146	7	with	with	IN
cord-260476-whfyczcj	146	8	the	the	DT
cord-260476-whfyczcj	146	9	viral	viral	JJ
cord-260476-whfyczcj	146	10	capsid	capsid	NN
cord-260476-whfyczcj	146	11	enhances	enhance	VBZ
cord-260476-whfyczcj	146	12	its	-PRON-	PRP$
cord-260476-whfyczcj	146	13	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	146	14	ligase	ligase	NN
cord-260476-whfyczcj	146	15	activity	activity	NN
cord-260476-whfyczcj	146	16	,	,	,
cord-260476-whfyczcj	146	17	which	which	WDT
cord-260476-whfyczcj	146	18	,	,	,
cord-260476-whfyczcj	146	19	in	in	IN
cord-260476-whfyczcj	146	20	conjunction	conjunction	NN
cord-260476-whfyczcj	146	21	with	with	IN
cord-260476-whfyczcj	146	22	the	the	DT
cord-260476-whfyczcj	146	23	E2	E2	NNP
cord-260476-whfyczcj	146	24	enzyme	enzyme	NN
cord-260476-whfyczcj	146	25	UBC13	UBC13	NNP
cord-260476-whfyczcj	146	26	/	/	SYM
cord-260476-whfyczcj	146	27	UEV1A	UEV1A	.
cord-260476-whfyczcj	147	1	(	(	-LRB-
cord-260476-whfyczcj	147	2	UBiquitin	UBiquitin	NNP
cord-260476-whfyczcj	147	3	-	-	HYPH
cord-260476-whfyczcj	147	4	Conjugating	Conjugating	NNP
cord-260476-whfyczcj	147	5	enzyme	enzyme	NN
cord-260476-whfyczcj	147	6	13	13	CD
cord-260476-whfyczcj	147	7	/	/	SYM
cord-260476-whfyczcj	147	8	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	147	9	-	-	HYPH
cord-260476-whfyczcj	147	10	conjugating	conjugate	VBG
cord-260476-whfyczcj	147	11	Enzyme	Enzyme	NNP
cord-260476-whfyczcj	147	12	Variant	Variant	NNP
cord-260476-whfyczcj	147	13	1A	1a	NN
cord-260476-whfyczcj	147	14	)	)	-RRB-
cord-260476-whfyczcj	147	15	,	,	,
cord-260476-whfyczcj	147	16	leads	lead	VBZ
cord-260476-whfyczcj	147	17	to	to	IN
cord-260476-whfyczcj	147	18	the	the	DT
cord-260476-whfyczcj	147	19	synthesis	synthesis	NN
cord-260476-whfyczcj	147	20	of	of	IN
cord-260476-whfyczcj	147	21	free	free	JJ
cord-260476-whfyczcj	147	22	K63-linked	K63-linked	NNP
cord-260476-whfyczcj	147	23	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	147	24	chains	chain	NNS
cord-260476-whfyczcj	147	25	,	,	,
cord-260476-whfyczcj	147	26	thus	thus	RB
cord-260476-whfyczcj	147	27	stimulating	stimulate	VBG
cord-260476-whfyczcj	147	28	TAK1	TAK1	NNP
cord-260476-whfyczcj	147	29	(	(	-LRB-
cord-260476-whfyczcj	147	30	Transforming	transform	VBG
cord-260476-whfyczcj	147	31	growth	growth	NN
cord-260476-whfyczcj	147	32	factor	factor	NN
cord-260476-whfyczcj	147	33	β	β	NN
cord-260476-whfyczcj	147	34	-	-	HYPH
cord-260476-whfyczcj	147	35	Activated	activate	VBN
cord-260476-whfyczcj	147	36	Kinase	Kinase	NNP
cord-260476-whfyczcj	147	37	1	1	CD
cord-260476-whfyczcj	147	38	)	)	-RRB-
cord-260476-whfyczcj	147	39	and	and	CC
cord-260476-whfyczcj	147	40	finally	finally	RB
cord-260476-whfyczcj	147	41	activating	activate	VBG
cord-260476-whfyczcj	147	42	AP1	AP1	NNP
cord-260476-whfyczcj	147	43	and	and	CC
cord-260476-whfyczcj	147	44	NF-ϰB	nf-ϰb	NN
cord-260476-whfyczcj	147	45	signaling	signal	VBG
cord-260476-whfyczcj	147	46	(	(	-LRB-
cord-260476-whfyczcj	147	47	Figure	figure	NN
cord-260476-whfyczcj	147	48	3C	3c	NN
cord-260476-whfyczcj	147	49	)	)	-RRB-
cord-260476-whfyczcj	147	50	[	[	-LRB-
cord-260476-whfyczcj	147	51	94	94	CD
cord-260476-whfyczcj	147	52	,	,	,
cord-260476-whfyczcj	147	53	95	95	CD
cord-260476-whfyczcj	147	54	]	]	-RRB-
cord-260476-whfyczcj	147	55	.	.	.
cord-260476-whfyczcj	148	1	This	this	DT
cord-260476-whfyczcj	148	2	indicates	indicate	VBZ
cord-260476-whfyczcj	148	3	that	that	IN
cord-260476-whfyczcj	148	4	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	148	5	,	,	,
cord-260476-whfyczcj	148	6	in	in	IN
cord-260476-whfyczcj	148	7	addition	addition	NN
cord-260476-whfyczcj	148	8	to	to	IN
cord-260476-whfyczcj	148	9	its	-PRON-	PRP$
cord-260476-whfyczcj	148	10	direct	direct	JJ
cord-260476-whfyczcj	148	11	antiviral	antiviral	JJ
cord-260476-whfyczcj	148	12	activity	activity	NN
cord-260476-whfyczcj	148	13	,	,	,
cord-260476-whfyczcj	148	14	also	also	RB
cord-260476-whfyczcj	148	15	functions	function	VBZ
cord-260476-whfyczcj	148	16	as	as	IN
cord-260476-whfyczcj	148	17	a	a	DT
cord-260476-whfyczcj	148	18	sensor	sensor	NN
cord-260476-whfyczcj	148	19	that	that	WDT
cord-260476-whfyczcj	148	20	induces	induce	VBZ
cord-260476-whfyczcj	148	21	a	a	DT
cord-260476-whfyczcj	148	22	general	general	JJ
cord-260476-whfyczcj	148	23	antiviral	antiviral	JJ
cord-260476-whfyczcj	148	24	state	state	NN
cord-260476-whfyczcj	148	25	of	of	IN
cord-260476-whfyczcj	148	26	the	the	DT
cord-260476-whfyczcj	148	27	cell	cell	NN
cord-260476-whfyczcj	148	28	.	.	.
cord-260476-whfyczcj	149	1	(	(	-LRB-
cord-260476-whfyczcj	149	2	D	D	NNP
cord-260476-whfyczcj	149	3	)	)	-RRB-
cord-260476-whfyczcj	149	4	March8	March8	NNP
cord-260476-whfyczcj	150	1	(	(	-LRB-
cord-260476-whfyczcj	150	2	red	red	NNP
cord-260476-whfyczcj	150	3	)	)	-RRB-
cord-260476-whfyczcj	150	4	mediates	mediate	VBZ
cord-260476-whfyczcj	150	5	intracellular	intracellular	JJ
cord-260476-whfyczcj	150	6	retention	retention	NN
cord-260476-whfyczcj	150	7	of	of	IN
cord-260476-whfyczcj	150	8	envelope	envelope	NN
cord-260476-whfyczcj	150	9	proteins	protein	NNS
cord-260476-whfyczcj	150	10	(	(	-LRB-
cord-260476-whfyczcj	150	11	Env	Env	NNP
cord-260476-whfyczcj	150	12	,	,	,
cord-260476-whfyczcj	150	13	brown	brown	NNP
cord-260476-whfyczcj	150	14	)	)	-RRB-
cord-260476-whfyczcj	150	15	,	,	,
cord-260476-whfyczcj	150	16	leading	lead	VBG
cord-260476-whfyczcj	150	17	to	to	IN
cord-260476-whfyczcj	150	18	reduced	reduce	VBN
cord-260476-whfyczcj	150	19	Env	env	NN
cord-260476-whfyczcj	150	20	incorporation	incorporation	NN
cord-260476-whfyczcj	150	21	into	into	IN
cord-260476-whfyczcj	150	22	virions	virion	NNS
cord-260476-whfyczcj	150	23	,	,	,
cord-260476-whfyczcj	150	24	thereby	thereby	RB
cord-260476-whfyczcj	150	25	decreasing	decrease	VBG
cord-260476-whfyczcj	150	26	infectivity	infectivity	NN
cord-260476-whfyczcj	150	27	.	.	.
cord-260476-whfyczcj	150	28	 	 	_SP
cord-260476-whfyczcj	151	1	March8	March8	NNP
cord-260476-whfyczcj	151	2	has	have	VBZ
cord-260476-whfyczcj	151	3	recently	recently	RB
cord-260476-whfyczcj	151	4	been	be	VBN
cord-260476-whfyczcj	151	5	identified	identify	VBN
cord-260476-whfyczcj	151	6	as	as	IN
cord-260476-whfyczcj	151	7	a	a	DT
cord-260476-whfyczcj	151	8	restriction	restriction	NN
cord-260476-whfyczcj	151	9	factor	factor	NN
cord-260476-whfyczcj	151	10	of	of	IN
cord-260476-whfyczcj	151	11	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	151	12	,	,	,
cord-260476-whfyczcj	151	13	expressed	express	VBN
cord-260476-whfyczcj	151	14	by	by	IN
cord-260476-whfyczcj	151	15	differentiated	differentiated	JJ
cord-260476-whfyczcj	151	16	myeloid	myeloid	NN
cord-260476-whfyczcj	151	17	cells	cell	NNS
cord-260476-whfyczcj	151	18	like	like	IN
cord-260476-whfyczcj	151	19	monocyte	monocyte	NNP
cord-260476-whfyczcj	151	20	derived	derive	VBD
cord-260476-whfyczcj	151	21	macrophages	macrophage	NNS
cord-260476-whfyczcj	151	22	and	and	CC
cord-260476-whfyczcj	151	23	dendritic	dendritic	JJ
cord-260476-whfyczcj	151	24	cells	cell	NNS
cord-260476-whfyczcj	151	25	[	[	-LRB-
cord-260476-whfyczcj	151	26	78	78	CD
cord-260476-whfyczcj	151	27	]	]	-RRB-
cord-260476-whfyczcj	151	28	.	.	.
cord-260476-whfyczcj	152	1	March8	March8	NNP
cord-260476-whfyczcj	152	2	significantly	significantly	RB
cord-260476-whfyczcj	152	3	reduces	reduce	VBZ
cord-260476-whfyczcj	152	4	infectivity	infectivity	NN
cord-260476-whfyczcj	152	5	of	of	IN
cord-260476-whfyczcj	152	6	virions	virion	NNS
cord-260476-whfyczcj	152	7	produced	produce	VBN
cord-260476-whfyczcj	152	8	from	from	IN
cord-260476-whfyczcj	152	9	March8-expressing	march8-expresse	VBG
cord-260476-whfyczcj	152	10	cells	cell	NNS
cord-260476-whfyczcj	152	11	by	by	IN
cord-260476-whfyczcj	152	12	decreasing	decrease	VBG
cord-260476-whfyczcj	152	13	the	the	DT
cord-260476-whfyczcj	152	14	number	number	NN
cord-260476-whfyczcj	152	15	of	of	IN
cord-260476-whfyczcj	152	16	Env	Env	NNP
cord-260476-whfyczcj	152	17	-	-	HYPH
cord-260476-whfyczcj	152	18	proteins	protein	NNS
cord-260476-whfyczcj	152	19	incorporated	incorporate	VBN
cord-260476-whfyczcj	152	20	into	into	IN
cord-260476-whfyczcj	152	21	budding	bud	VBG
cord-260476-whfyczcj	152	22	virions	virion	NNS
cord-260476-whfyczcj	152	23	.	.	.
cord-260476-whfyczcj	153	1	March8	March8	NNP
cord-260476-whfyczcj	153	2	is	be	VBZ
cord-260476-whfyczcj	153	3	a	a	DT
cord-260476-whfyczcj	153	4	transmembrane	transmembrane	NN
cord-260476-whfyczcj	153	5	E3-ubiquitin	E3-ubiquitin	NNS
cord-260476-whfyczcj	153	6	ligase	ligase	NN
cord-260476-whfyczcj	153	7	,	,	,
cord-260476-whfyczcj	153	8	possessing	possess	VBG
cord-260476-whfyczcj	153	9	an	an	DT
cord-260476-whfyczcj	153	10	N	n	CD
cord-260476-whfyczcj	153	11	-	-	HYPH
cord-260476-whfyczcj	153	12	terminal	terminal	NN
cord-260476-whfyczcj	153	13	,	,	,
cord-260476-whfyczcj	153	14	cytoplasmic	cytoplasmic	JJ
cord-260476-whfyczcj	153	15	RING	ring	NN
cord-260476-whfyczcj	153	16	domain	domain	NN
cord-260476-whfyczcj	153	17	(	(	-LRB-
cord-260476-whfyczcj	153	18	Figure	figure	NN
cord-260476-whfyczcj	153	19	3B	3b	CD
cord-260476-whfyczcj	153	20	)	)	-RRB-
cord-260476-whfyczcj	153	21	,	,	,
cord-260476-whfyczcj	153	22	known	know	VBN
cord-260476-whfyczcj	153	23	to	to	TO
cord-260476-whfyczcj	153	24	downregulate	downregulate	VB
cord-260476-whfyczcj	153	25	multiple	multiple	JJ
cord-260476-whfyczcj	153	26	cellular	cellular	JJ
cord-260476-whfyczcj	153	27	proteins	protein	NNS
cord-260476-whfyczcj	153	28	from	from	IN
cord-260476-whfyczcj	153	29	the	the	DT
cord-260476-whfyczcj	153	30	plasma	plasma	NN
cord-260476-whfyczcj	153	31	membrane	membrane	NN
cord-260476-whfyczcj	153	32	by	by	IN
cord-260476-whfyczcj	153	33	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	153	34	followed	follow	VBN
cord-260476-whfyczcj	153	35	by	by	IN
cord-260476-whfyczcj	153	36	degradation	degradation	NN
cord-260476-whfyczcj	153	37	in	in	IN
cord-260476-whfyczcj	153	38	the	the	DT
cord-260476-whfyczcj	153	39	endo	endo	NN
cord-260476-whfyczcj	153	40	-	-	HYPH
cord-260476-whfyczcj	153	41	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	153	42	pathway	pathway	NN
cord-260476-whfyczcj	153	43	[	[	-LRB-
cord-260476-whfyczcj	153	44	96	96	CD
cord-260476-whfyczcj	153	45	]	]	-RRB-
cord-260476-whfyczcj	153	46	[	[	-LRB-
cord-260476-whfyczcj	153	47	97	97	CD
cord-260476-whfyczcj	153	48	]	]	-RRB-
cord-260476-whfyczcj	153	49	[	[	-LRB-
cord-260476-whfyczcj	153	50	98	98	CD
cord-260476-whfyczcj	153	51	]	]	-RRB-
cord-260476-whfyczcj	153	52	[	[	-LRB-
cord-260476-whfyczcj	153	53	99	99	CD
cord-260476-whfyczcj	153	54	]	]	-RRB-
cord-260476-whfyczcj	153	55	.	.	.
cord-260476-whfyczcj	154	1	In	in	IN
cord-260476-whfyczcj	154	2	the	the	DT
cord-260476-whfyczcj	154	3	case	case	NN
cord-260476-whfyczcj	154	4	of	of	IN
cord-260476-whfyczcj	154	5	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	154	6	restriction	restriction	NN
cord-260476-whfyczcj	154	7	,	,	,
cord-260476-whfyczcj	154	8	it	-PRON-	PRP
cord-260476-whfyczcj	154	9	has	have	VBZ
cord-260476-whfyczcj	154	10	been	be	VBN
cord-260476-whfyczcj	154	11	shown	show	VBN
cord-260476-whfyczcj	154	12	that	that	IN
cord-260476-whfyczcj	154	13	March8	March8	NNP
cord-260476-whfyczcj	154	14	interacts	interact	VBZ
cord-260476-whfyczcj	154	15	with	with	IN
cord-260476-whfyczcj	154	16	Env	Env	NNP
cord-260476-whfyczcj	154	17	and	and	CC
cord-260476-whfyczcj	154	18	causes	cause	VBZ
cord-260476-whfyczcj	154	19	its	-PRON-	PRP$
cord-260476-whfyczcj	154	20	downregulation	downregulation	NN
cord-260476-whfyczcj	154	21	from	from	IN
cord-260476-whfyczcj	154	22	the	the	DT
cord-260476-whfyczcj	154	23	cell	cell	NN
cord-260476-whfyczcj	154	24	surface	surface	NN
cord-260476-whfyczcj	154	25	.	.	.
cord-260476-whfyczcj	155	1	The	the	DT
cord-260476-whfyczcj	155	2	RING	ring	NN
cord-260476-whfyczcj	155	3	-	-	HYPH
cord-260476-whfyczcj	155	4	domain	domain	NN
cord-260476-whfyczcj	155	5	of	of	IN
cord-260476-whfyczcj	155	6	March8	March8	NNP
cord-260476-whfyczcj	155	7	is	be	VBZ
cord-260476-whfyczcj	155	8	necessary	necessary	JJ
cord-260476-whfyczcj	155	9	for	for	IN
cord-260476-whfyczcj	155	10	this	this	DT
cord-260476-whfyczcj	155	11	mechanism	mechanism	NN
cord-260476-whfyczcj	155	12	,	,	,
cord-260476-whfyczcj	155	13	suggesting	suggest	VBG
cord-260476-whfyczcj	155	14	that	that	IN
cord-260476-whfyczcj	155	15	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	155	16	plays	play	VBZ
cord-260476-whfyczcj	155	17	a	a	DT
cord-260476-whfyczcj	155	18	role	role	NN
cord-260476-whfyczcj	155	19	.	.	.
cord-260476-whfyczcj	156	1	However	however	RB
cord-260476-whfyczcj	156	2	,	,	,
cord-260476-whfyczcj	156	3	Env	Env	NNP
cord-260476-whfyczcj	156	4	does	do	VBZ
cord-260476-whfyczcj	156	5	not	not	RB
cord-260476-whfyczcj	156	6	seem	seem	VB
cord-260476-whfyczcj	156	7	to	to	TO
cord-260476-whfyczcj	156	8	be	be	VB
cord-260476-whfyczcj	156	9	degraded	degrade	VBN
cord-260476-whfyczcj	156	10	in	in	IN
cord-260476-whfyczcj	156	11	the	the	DT
cord-260476-whfyczcj	156	12	endo	endo	NN
cord-260476-whfyczcj	156	13	-	-	HYPH
cord-260476-whfyczcj	156	14	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	156	15	pathway	pathway	NN
cord-260476-whfyczcj	156	16	like	like	IN
cord-260476-whfyczcj	156	17	cellular	cellular	JJ
cord-260476-whfyczcj	156	18	proteins	protein	NNS
cord-260476-whfyczcj	156	19	targeted	target	VBN
cord-260476-whfyczcj	156	20	by	by	IN
cord-260476-whfyczcj	156	21	March8	March8	NNP
cord-260476-whfyczcj	157	1	but	but	CC
cord-260476-whfyczcj	157	2	seems	seem	VBZ
cord-260476-whfyczcj	157	3	rather	rather	RB
cord-260476-whfyczcj	157	4	to	to	TO
cord-260476-whfyczcj	157	5	be	be	VB
cord-260476-whfyczcj	157	6	retained	retain	VBN
cord-260476-whfyczcj	157	7	in	in	IN
cord-260476-whfyczcj	157	8	intracellular	intracellular	JJ
cord-260476-whfyczcj	157	9	compartments	compartment	NNS
cord-260476-whfyczcj	157	10	.	.	.
cord-260476-whfyczcj	158	1	March8	March8	NNP
cord-260476-whfyczcj	158	2	thus	thus	RB
cord-260476-whfyczcj	158	3	sequesters	sequester	VBZ
cord-260476-whfyczcj	158	4	Env	Env	NNP
cord-260476-whfyczcj	158	5	away	away	RB
cord-260476-whfyczcj	158	6	from	from	IN
cord-260476-whfyczcj	158	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	158	8	budding	bud	VBG
cord-260476-whfyczcj	158	9	sites	site	NNS
cord-260476-whfyczcj	158	10	,	,	,
cord-260476-whfyczcj	158	11	thereby	thereby	RB
cord-260476-whfyczcj	158	12	reducing	reduce	VBG
cord-260476-whfyczcj	158	13	Env	Env	NNP
cord-260476-whfyczcj	158	14	incorporation	incorporation	NN
cord-260476-whfyczcj	158	15	into	into	IN
cord-260476-whfyczcj	158	16	newly	newly	RB
cord-260476-whfyczcj	158	17	formed	form	VBN
cord-260476-whfyczcj	158	18	virions	virion	NNS
cord-260476-whfyczcj	158	19	,	,	,
cord-260476-whfyczcj	158	20	making	make	VBG
cord-260476-whfyczcj	158	21	them	-PRON-	PRP
cord-260476-whfyczcj	158	22	less	less	RBR
cord-260476-whfyczcj	158	23	competent	competent	JJ
cord-260476-whfyczcj	158	24	for	for	IN
cord-260476-whfyczcj	158	25	infection	infection	NN
cord-260476-whfyczcj	158	26	of	of	IN
cord-260476-whfyczcj	158	27	new	new	JJ
cord-260476-whfyczcj	158	28	target	target	NN
cord-260476-whfyczcj	158	29	cells	cell	NNS
cord-260476-whfyczcj	158	30	(	(	-LRB-
cord-260476-whfyczcj	158	31	Figure	Figure	NNP
cord-260476-whfyczcj	158	32	3D	3D	NNP
cord-260476-whfyczcj	158	33	)	)	-RRB-
cord-260476-whfyczcj	158	34	[	[	-LRB-
cord-260476-whfyczcj	158	35	78	78	CD
cord-260476-whfyczcj	158	36	]	]	-RRB-
cord-260476-whfyczcj	158	37	.	.	.
cord-260476-whfyczcj	159	1	The	the	DT
cord-260476-whfyczcj	159	2	family	family	NN
cord-260476-whfyczcj	159	3	of	of	IN
cord-260476-whfyczcj	159	4	Apolipoprotein	Apolipoprotein	NNP
cord-260476-whfyczcj	159	5	B	B	NNP
cord-260476-whfyczcj	159	6	mRNA	mrna	NN
cord-260476-whfyczcj	159	7	-	-	HYPH
cord-260476-whfyczcj	159	8	editing	editing	NN
cord-260476-whfyczcj	159	9	enzyme	enzyme	NN
cord-260476-whfyczcj	159	10	,	,	,
cord-260476-whfyczcj	159	11	catalytic	catalytic	JJ
cord-260476-whfyczcj	159	12	polypeptide	polypeptide	NN
cord-260476-whfyczcj	159	13	-	-	HYPH
cord-260476-whfyczcj	159	14	like	like	JJ
cord-260476-whfyczcj	159	15	3	3	CD
cord-260476-whfyczcj	159	16	(	(	-LRB-
cord-260476-whfyczcj	159	17	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	159	18	/	/	SYM
cord-260476-whfyczcj	159	19	A3	A3	NNP
cord-260476-whfyczcj	159	20	)	)	-RRB-
cord-260476-whfyczcj	159	21	proteins	protein	NNS
cord-260476-whfyczcj	159	22	,	,	,
cord-260476-whfyczcj	159	23	is	be	VBZ
cord-260476-whfyczcj	159	24	a	a	DT
cord-260476-whfyczcj	159	25	family	family	NN
cord-260476-whfyczcj	159	26	of	of	IN
cord-260476-whfyczcj	159	27	7	7	CD
cord-260476-whfyczcj	159	28	cytosine	cytosine	JJ
cord-260476-whfyczcj	159	29	deaminases	deaminase	NNS
cord-260476-whfyczcj	159	30	(	(	-LRB-
cord-260476-whfyczcj	159	31	A3A	a3a	CD
cord-260476-whfyczcj	159	32	to	to	IN
cord-260476-whfyczcj	159	33	A3H	a3h	LS
cord-260476-whfyczcj	159	34	)	)	-RRB-
cord-260476-whfyczcj	159	35	which	which	WDT
cord-260476-whfyczcj	159	36	induce	induce	VBP
cord-260476-whfyczcj	159	37	transition	transition	NN
cord-260476-whfyczcj	159	38	of	of	IN
cord-260476-whfyczcj	159	39	cytosine	cytosine	NN
cord-260476-whfyczcj	159	40	to	to	IN
cord-260476-whfyczcj	159	41	uracil	uracil	NN
cord-260476-whfyczcj	159	42	on	on	IN
cord-260476-whfyczcj	159	43	single	single	RB
cord-260476-whfyczcj	159	44	-	-	HYPH
cord-260476-whfyczcj	159	45	stranded	strand	VBN
cord-260476-whfyczcj	159	46	DNA	dna	NN
cord-260476-whfyczcj	159	47	,	,	,
cord-260476-whfyczcj	159	48	with	with	IN
cord-260476-whfyczcj	159	49	a	a	DT
cord-260476-whfyczcj	159	50	preferential	preferential	JJ
cord-260476-whfyczcj	159	51	recognition	recognition	NN
cord-260476-whfyczcj	159	52	of	of	IN
cord-260476-whfyczcj	159	53	CC	cc	NN
cord-260476-whfyczcj	159	54	sequence	sequence	NN
cord-260476-whfyczcj	159	55	motifs	motif	NNS
cord-260476-whfyczcj	159	56	by	by	IN
cord-260476-whfyczcj	159	57	A3	A3	NNP
cord-260476-whfyczcj	159	58	G	G	NNP
cord-260476-whfyczcj	159	59	and	and	CC
cord-260476-whfyczcj	159	60	TC	TC	NNP
cord-260476-whfyczcj	159	61	motifs	motif	NNS
cord-260476-whfyczcj	159	62	by	by	IN
cord-260476-whfyczcj	159	63	the	the	DT
cord-260476-whfyczcj	159	64	others	other	NNS
cord-260476-whfyczcj	159	65	[	[	-LRB-
cord-260476-whfyczcj	159	66	100	100	CD
cord-260476-whfyczcj	159	67	]	]	-RRB-
cord-260476-whfyczcj	159	68	[	[	-LRB-
cord-260476-whfyczcj	159	69	101	101	CD
cord-260476-whfyczcj	159	70	]	]	-RRB-
cord-260476-whfyczcj	159	71	[	[	-LRB-
cord-260476-whfyczcj	159	72	102	102	CD
cord-260476-whfyczcj	159	73	]	]	-RRB-
cord-260476-whfyczcj	159	74	.	.	.
cord-260476-whfyczcj	160	1	A3	A3	NNP
cord-260476-whfyczcj	160	2	G	G	NNP
cord-260476-whfyczcj	160	3	(	(	-LRB-
cord-260476-whfyczcj	160	4	Figure	figure	NN
cord-260476-whfyczcj	160	5	4A	4a	CD
cord-260476-whfyczcj	160	6	)	)	-RRB-
cord-260476-whfyczcj	160	7	has	have	VBZ
cord-260476-whfyczcj	160	8	been	be	VBN
cord-260476-whfyczcj	160	9	the	the	DT
cord-260476-whfyczcj	160	10	first	first	JJ
cord-260476-whfyczcj	160	11	member	member	NN
cord-260476-whfyczcj	160	12	of	of	IN
cord-260476-whfyczcj	160	13	this	this	DT
cord-260476-whfyczcj	160	14	family	family	NN
cord-260476-whfyczcj	160	15	to	to	TO
cord-260476-whfyczcj	160	16	be	be	VB
cord-260476-whfyczcj	160	17	identified	identify	VBN
cord-260476-whfyczcj	160	18	as	as	IN
cord-260476-whfyczcj	160	19	a	a	DT
cord-260476-whfyczcj	160	20	potent	potent	JJ
cord-260476-whfyczcj	160	21	antiviral	antiviral	JJ
cord-260476-whfyczcj	160	22	factor	factor	NN
cord-260476-whfyczcj	160	23	.	.	.
cord-260476-whfyczcj	161	1	It	-PRON-	PRP
cord-260476-whfyczcj	161	2	is	be	VBZ
cord-260476-whfyczcj	161	3	incorporated	incorporate	VBN
cord-260476-whfyczcj	161	4	into	into	IN
cord-260476-whfyczcj	161	5	budding	bud	VBG
cord-260476-whfyczcj	161	6	HIV	HIV	NNP
cord-260476-whfyczcj	161	7	virions	virion	NNS
cord-260476-whfyczcj	161	8	and	and	CC
cord-260476-whfyczcj	161	9	is	be	VBZ
cord-260476-whfyczcj	161	10	thereby	thereby	RB
cord-260476-whfyczcj	161	11	carried	carry	VBN
cord-260476-whfyczcj	161	12	over	over	RP
cord-260476-whfyczcj	161	13	into	into	IN
cord-260476-whfyczcj	161	14	the	the	DT
cord-260476-whfyczcj	161	15	next	next	JJ
cord-260476-whfyczcj	161	16	infected	infected	JJ
cord-260476-whfyczcj	161	17	cell	cell	NN
cord-260476-whfyczcj	161	18	[	[	-LRB-
cord-260476-whfyczcj	161	19	69	69	CD
cord-260476-whfyczcj	161	20	]	]	-RRB-
cord-260476-whfyczcj	161	21	.	.	.
cord-260476-whfyczcj	162	1	During	during	IN
cord-260476-whfyczcj	162	2	reverse	reverse	JJ
cord-260476-whfyczcj	162	3	transcription	transcription	NN
cord-260476-whfyczcj	162	4	of	of	IN
cord-260476-whfyczcj	162	5	the	the	DT
cord-260476-whfyczcj	162	6	viral	viral	JJ
cord-260476-whfyczcj	162	7	genomic	genomic	JJ
cord-260476-whfyczcj	162	8	RNA	RNA	NNP
cord-260476-whfyczcj	162	9	,	,	,
cord-260476-whfyczcj	162	10	the	the	DT
cord-260476-whfyczcj	162	11	single	single	JJ
cord-260476-whfyczcj	162	12	stranded	strand	VBN
cord-260476-whfyczcj	162	13	negative	negative	JJ
cord-260476-whfyczcj	162	14	sense	sense	NN
cord-260476-whfyczcj	162	15	DNA	DNA	NNP
cord-260476-whfyczcj	162	16	is	be	VBZ
cord-260476-whfyczcj	162	17	sensitive	sensitive	JJ
cord-260476-whfyczcj	162	18	to	to	IN
cord-260476-whfyczcj	162	19	the	the	DT
cord-260476-whfyczcj	162	20	cytosine	cytosine	NN
cord-260476-whfyczcj	162	21	-	-	HYPH
cord-260476-whfyczcj	162	22	deaminase	deaminase	JJ
cord-260476-whfyczcj	162	23	activity	activity	NN
cord-260476-whfyczcj	162	24	of	of	IN
cord-260476-whfyczcj	162	25	A3	A3	NNP
cord-260476-whfyczcj	162	26	G	G	NNP
cord-260476-whfyczcj	162	27	,	,	,
cord-260476-whfyczcj	162	28	leading	lead	VBG
cord-260476-whfyczcj	162	29	to	to	IN
cord-260476-whfyczcj	162	30	C	c	NN
cord-260476-whfyczcj	162	31	to	to	IN
cord-260476-whfyczcj	162	32	U	u	NN
cord-260476-whfyczcj	162	33	transitions	transition	NNS
cord-260476-whfyczcj	162	34	[	[	-LRB-
cord-260476-whfyczcj	162	35	70	70	CD
cord-260476-whfyczcj	162	36	,	,	,
cord-260476-whfyczcj	162	37	71	71	CD
cord-260476-whfyczcj	162	38	]	]	-RRB-
cord-260476-whfyczcj	162	39	.	.	.
cord-260476-whfyczcj	163	1	These	these	DT
cord-260476-whfyczcj	163	2	mutations	mutation	NNS
cord-260476-whfyczcj	163	3	can	can	MD
cord-260476-whfyczcj	163	4	either	either	CC
cord-260476-whfyczcj	163	5	be	be	VB
cord-260476-whfyczcj	163	6	recognized	recognize	VBN
cord-260476-whfyczcj	163	7	by	by	IN
cord-260476-whfyczcj	163	8	uracil	uracil	NN
cord-260476-whfyczcj	163	9	DNA	dna	NN
cord-260476-whfyczcj	163	10	glycosylases	glycosylase	NNS
cord-260476-whfyczcj	163	11	,	,	,
cord-260476-whfyczcj	163	12	like	like	IN
cord-260476-whfyczcj	163	13	the	the	DT
cord-260476-whfyczcj	163	14	virion	virion	NN
cord-260476-whfyczcj	163	15	-	-	HYPH
cord-260476-whfyczcj	163	16	associated	associate	VBN
cord-260476-whfyczcj	163	17	UNG2	UNG2	NNP
cord-260476-whfyczcj	163	18	(	(	-LRB-
cord-260476-whfyczcj	163	19	Uracyl	Uracyl	NNP
cord-260476-whfyczcj	163	20	N	N	NNP
cord-260476-whfyczcj	163	21	-	-	HYPH
cord-260476-whfyczcj	163	22	Glycosylase	Glycosylase	NNP
cord-260476-whfyczcj	163	23	2	2	CD
cord-260476-whfyczcj	163	24	)	)	-RRB-
cord-260476-whfyczcj	163	25	,	,	,
cord-260476-whfyczcj	163	26	leading	lead	VBG
cord-260476-whfyczcj	163	27	to	to	IN
cord-260476-whfyczcj	163	28	the	the	DT
cord-260476-whfyczcj	163	29	degradation	degradation	NN
cord-260476-whfyczcj	163	30	of	of	IN
cord-260476-whfyczcj	163	31	the	the	DT
cord-260476-whfyczcj	163	32	provirus	provirus	NNP
cord-260476-whfyczcj	163	33	by	by	IN
cord-260476-whfyczcj	163	34	abasic	abasic	NN
cord-260476-whfyczcj	163	35	site	site	NN
cord-260476-whfyczcj	163	36	endonucleases	endonuclease	NNS
cord-260476-whfyczcj	163	37	[	[	-LRB-
cord-260476-whfyczcj	163	38	103	103	CD
cord-260476-whfyczcj	163	39	]	]	-RRB-
cord-260476-whfyczcj	163	40	,	,	,
cord-260476-whfyczcj	163	41	or	or	CC
cord-260476-whfyczcj	163	42	they	-PRON-	PRP
cord-260476-whfyczcj	163	43	can	can	MD
cord-260476-whfyczcj	163	44	be	be	VB
cord-260476-whfyczcj	163	45	conserved	conserve	VBN
cord-260476-whfyczcj	163	46	in	in	IN
cord-260476-whfyczcj	163	47	the	the	DT
cord-260476-whfyczcj	163	48	provirus	provirus	NNP
cord-260476-whfyczcj	163	49	.	.	.
cord-260476-whfyczcj	164	1	Due	due	IN
cord-260476-whfyczcj	164	2	to	to	IN
cord-260476-whfyczcj	164	3	the	the	DT
cord-260476-whfyczcj	164	4	sequence	sequence	NN
cord-260476-whfyczcj	164	5	preference	preference	NN
cord-260476-whfyczcj	164	6	of	of	IN
cord-260476-whfyczcj	164	7	A3	A3	NNP
cord-260476-whfyczcj	164	8	G	G	NNP
cord-260476-whfyczcj	164	9	,	,	,
cord-260476-whfyczcj	164	10	these	these	DT
cord-260476-whfyczcj	164	11	mutations	mutation	NNS
cord-260476-whfyczcj	164	12	very	very	RB
cord-260476-whfyczcj	164	13	frequently	frequently	RB
cord-260476-whfyczcj	164	14	introduce	introduce	VBP
cord-260476-whfyczcj	164	15	new	new	JJ
cord-260476-whfyczcj	164	16	stop	stop	NN
cord-260476-whfyczcj	164	17	codons	codon	NNS
cord-260476-whfyczcj	164	18	in	in	IN
cord-260476-whfyczcj	164	19	the	the	DT
cord-260476-whfyczcj	164	20	viral	viral	JJ
cord-260476-whfyczcj	164	21	genome	genome	NN
cord-260476-whfyczcj	164	22	,	,	,
cord-260476-whfyczcj	164	23	thus	thus	RB
cord-260476-whfyczcj	164	24	leading	lead	VBG
cord-260476-whfyczcj	164	25	to	to	IN
cord-260476-whfyczcj	164	26	the	the	DT
cord-260476-whfyczcj	164	27	expression	expression	NN
cord-260476-whfyczcj	164	28	of	of	IN
cord-260476-whfyczcj	164	29	non	non	JJ
cord-260476-whfyczcj	164	30	-	-	JJ
cord-260476-whfyczcj	164	31	functional	functional	JJ
cord-260476-whfyczcj	164	32	mutated	mutate	VBN
cord-260476-whfyczcj	164	33	or	or	CC
cord-260476-whfyczcj	164	34	/	/	SYM
cord-260476-whfyczcj	164	35	and	and	CC
cord-260476-whfyczcj	164	36	truncated	truncated	JJ
cord-260476-whfyczcj	164	37	viral	viral	JJ
cord-260476-whfyczcj	164	38	proteins	protein	NNS
cord-260476-whfyczcj	164	39	(	(	-LRB-
cord-260476-whfyczcj	164	40	Figure	figure	NN
cord-260476-whfyczcj	164	41	4C	4c	CD
cord-260476-whfyczcj	164	42	)	)	-RRB-
cord-260476-whfyczcj	164	43	.	.	.
cord-260476-whfyczcj	165	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	165	2	counteracts	counteract	VBZ
cord-260476-whfyczcj	165	3	A3	A3	NNP
cord-260476-whfyczcj	165	4	G	G	NNP
cord-260476-whfyczcj	165	5	with	with	IN
cord-260476-whfyczcj	165	6	its	-PRON-	PRP$
cord-260476-whfyczcj	165	7	Vif	Vif	NNP
cord-260476-whfyczcj	165	8	protein	protein	NN
cord-260476-whfyczcj	165	9	,	,	,
cord-260476-whfyczcj	165	10	which	which	WDT
cord-260476-whfyczcj	165	11	prevents	prevent	VBZ
cord-260476-whfyczcj	165	12	A3	A3	NNP
cord-260476-whfyczcj	165	13	G	g	NN
cord-260476-whfyczcj	165	14	incorporation	incorporation	NN
cord-260476-whfyczcj	165	15	into	into	IN
cord-260476-whfyczcj	165	16	virions	virion	NNS
cord-260476-whfyczcj	165	17	by	by	IN
cord-260476-whfyczcj	165	18	inducing	induce	VBG
cord-260476-whfyczcj	165	19	its	-PRON-	PRP$
cord-260476-whfyczcj	165	20	degradation	degradation	NN
cord-260476-whfyczcj	165	21	through	through	IN
cord-260476-whfyczcj	165	22	the	the	DT
cord-260476-whfyczcj	165	23	proteasome	proteasome	NN
cord-260476-whfyczcj	165	24	[	[	-LRB-
cord-260476-whfyczcj	165	25	80	80	CD
cord-260476-whfyczcj	165	26	]	]	-RRB-
cord-260476-whfyczcj	165	27	.	.	.
cord-260476-whfyczcj	166	1	To	to	TO
cord-260476-whfyczcj	166	2	do	do	VB
cord-260476-whfyczcj	166	3	so	so	RB
cord-260476-whfyczcj	166	4	,	,	,
cord-260476-whfyczcj	166	5	Vif	Vif	NNP
cord-260476-whfyczcj	166	6	recruits	recruit	VBZ
cord-260476-whfyczcj	166	7	an	an	DT
cord-260476-whfyczcj	166	8	SCF	scf	NN
cord-260476-whfyczcj	166	9	-	-	HYPH
cord-260476-whfyczcj	166	10	like	like	JJ
cord-260476-whfyczcj	166	11	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	166	12	ligase	ligase	NN
cord-260476-whfyczcj	166	13	,	,	,
cord-260476-whfyczcj	166	14	composed	compose	VBN
cord-260476-whfyczcj	166	15	of	of	IN
cord-260476-whfyczcj	166	16	Cullin5	Cullin5	NNP
cord-260476-whfyczcj	166	17	,	,	,
cord-260476-whfyczcj	166	18	Rbx2	rbx2	NN
cord-260476-whfyczcj	166	19	,	,	,
cord-260476-whfyczcj	166	20	Elongin	Elongin	NNP
cord-260476-whfyczcj	166	21	B	B	NNP
cord-260476-whfyczcj	166	22	and	and	CC
cord-260476-whfyczcj	166	23	C.	C.	NNP
cord-260476-whfyczcj	167	1	In	in	IN
cord-260476-whfyczcj	167	2	this	this	DT
cord-260476-whfyczcj	167	3	complex	complex	NN
cord-260476-whfyczcj	167	4	,	,	,
cord-260476-whfyczcj	167	5	Vif	Vif	NNP
cord-260476-whfyczcj	167	6	possesses	possess	VBZ
cord-260476-whfyczcj	167	7	the	the	DT
cord-260476-whfyczcj	167	8	role	role	NN
cord-260476-whfyczcj	167	9	of	of	IN
cord-260476-whfyczcj	167	10	a	a	DT
cord-260476-whfyczcj	167	11	substrate	substrate	NN
cord-260476-whfyczcj	167	12	adaptor	adaptor	NN
cord-260476-whfyczcj	167	13	,	,	,
cord-260476-whfyczcj	167	14	directly	directly	RB
cord-260476-whfyczcj	167	15	interacting	interact	VBG
cord-260476-whfyczcj	167	16	with	with	IN
cord-260476-whfyczcj	167	17	A3	A3	NNP
cord-260476-whfyczcj	167	18	G	G	NNP
cord-260476-whfyczcj	167	19	through	through	IN
cord-260476-whfyczcj	167	20	its	-PRON-	PRP$
cord-260476-whfyczcj	167	21	N	n	CD
cord-260476-whfyczcj	167	22	-	-	HYPH
cord-260476-whfyczcj	167	23	terminal	terminal	NN
cord-260476-whfyczcj	167	24	domain	domain	NN
cord-260476-whfyczcj	167	25	(	(	-LRB-
cord-260476-whfyczcj	167	26	Figure	figure	NN
cord-260476-whfyczcj	167	27	4B	4b	NN
cord-260476-whfyczcj	167	28	)	)	-RRB-
cord-260476-whfyczcj	167	29	,	,	,
cord-260476-whfyczcj	167	30	thereby	thereby	RB
cord-260476-whfyczcj	167	31	recruiting	recruit	VBG
cord-260476-whfyczcj	167	32	it	-PRON-	PRP
cord-260476-whfyczcj	167	33	for	for	IN
cord-260476-whfyczcj	167	34	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	167	35	(	(	-LRB-
cord-260476-whfyczcj	167	36	Figure	figure	NN
cord-260476-whfyczcj	167	37	4C	4c	CD
cord-260476-whfyczcj	167	38	3	3	CD
cord-260476-whfyczcj	167	39	)	)	-RRB-
cord-260476-whfyczcj	167	40	[	[	-LRB-
cord-260476-whfyczcj	167	41	104	104	CD
cord-260476-whfyczcj	167	42	]	]	-RRB-
cord-260476-whfyczcj	167	43	.	.	.
cord-260476-whfyczcj	168	1	The	the	DT
cord-260476-whfyczcj	168	2	recruitment	recruitment	NN
cord-260476-whfyczcj	168	3	of	of	IN
cord-260476-whfyczcj	168	4	Cullin5	Cullin5	NNP
cord-260476-whfyczcj	168	5	is	be	VBZ
cord-260476-whfyczcj	168	6	mediated	mediate	VBN
cord-260476-whfyczcj	168	7	by	by	IN
cord-260476-whfyczcj	168	8	the	the	DT
cord-260476-whfyczcj	168	9	zinc	zinc	NN
cord-260476-whfyczcj	168	10	-	-	HYPH
cord-260476-whfyczcj	168	11	binding	bind	VBG
cord-260476-whfyczcj	168	12	domain	domain	NN
cord-260476-whfyczcj	168	13	of	of	IN
cord-260476-whfyczcj	168	14	Vif	Vif	NNP
cord-260476-whfyczcj	168	15	[	[	-LRB-
cord-260476-whfyczcj	168	16	105	105	CD
cord-260476-whfyczcj	168	17	]	]	-RRB-
cord-260476-whfyczcj	168	18	and	and	CC
cord-260476-whfyczcj	168	19	Cullin5	Cullin5	NNP
cord-260476-whfyczcj	168	20	in	in	IN
cord-260476-whfyczcj	168	21	turn	turn	NN
cord-260476-whfyczcj	168	22	recruits	recruit	VBZ
cord-260476-whfyczcj	168	23	the	the	DT
cord-260476-whfyczcj	168	24	E2-ubiquitin	e2-ubiquitin	RBR
cord-260476-whfyczcj	168	25	-	-	HYPH
cord-260476-whfyczcj	168	26	conjugating	conjugate	VBG
cord-260476-whfyczcj	168	27	enzyme	enzyme	NN
cord-260476-whfyczcj	168	28	Rbx2	rbx2	NN
cord-260476-whfyczcj	168	29	.	.	.
cord-260476-whfyczcj	169	1	The	the	DT
cord-260476-whfyczcj	169	2	recruitment	recruitment	NN
cord-260476-whfyczcj	169	3	of	of	IN
cord-260476-whfyczcj	169	4	Elongin	Elongin	NNP
cord-260476-whfyczcj	169	5	B	B	NNP
cord-260476-whfyczcj	169	6	and	and	CC
cord-260476-whfyczcj	169	7	C	C	NNP
cord-260476-whfyczcj	169	8	is	be	VBZ
cord-260476-whfyczcj	169	9	mediated	mediate	VBN
cord-260476-whfyczcj	169	10	by	by	IN
cord-260476-whfyczcj	169	11	the	the	DT
cord-260476-whfyczcj	169	12	BC	BC	NNP
cord-260476-whfyczcj	169	13	-	-	HYPH
cord-260476-whfyczcj	169	14	box	box	NN
cord-260476-whfyczcj	169	15	domain	domain	NN
cord-260476-whfyczcj	169	16	of	of	IN
cord-260476-whfyczcj	169	17	Vif	vif	NN
cord-260476-whfyczcj	169	18	(	(	-LRB-
cord-260476-whfyczcj	169	19	Figure	figure	NN
cord-260476-whfyczcj	169	20	4B	4b	NN
cord-260476-whfyczcj	169	21	)	)	-RRB-
cord-260476-whfyczcj	169	22	,	,	,
cord-260476-whfyczcj	169	23	which	which	WDT
cord-260476-whfyczcj	169	24	can	can	MD
cord-260476-whfyczcj	169	25	be	be	VB
cord-260476-whfyczcj	169	26	negatively	negatively	RB
cord-260476-whfyczcj	169	27	regulated	regulate	VBN
cord-260476-whfyczcj	169	28	by	by	IN
cord-260476-whfyczcj	169	29	phosphorylation	phosphorylation	NN
cord-260476-whfyczcj	169	30	.	.	.
cord-260476-whfyczcj	170	1	In	in	IN
cord-260476-whfyczcj	170	2	this	this	DT
cord-260476-whfyczcj	170	3	complex	complex	NN
cord-260476-whfyczcj	170	4	,	,	,
cord-260476-whfyczcj	170	5	not	not	RB
cord-260476-whfyczcj	170	6	only	only	RB
cord-260476-whfyczcj	170	7	A3	A3	NNP
cord-260476-whfyczcj	170	8	G	g	NN
cord-260476-whfyczcj	170	9	but	but	CC
cord-260476-whfyczcj	170	10	also	also	RB
cord-260476-whfyczcj	171	1	Vif	Vif	NNP
cord-260476-whfyczcj	171	2	is	be	VBZ
cord-260476-whfyczcj	171	3	ubiquitinated	ubiquitinate	VBN
cord-260476-whfyczcj	171	4	,	,	,
cord-260476-whfyczcj	171	5	which	which	WDT
cord-260476-whfyczcj	171	6	might	may	MD
cord-260476-whfyczcj	171	7	contribute	contribute	VB
cord-260476-whfyczcj	171	8	to	to	IN
cord-260476-whfyczcj	171	9	the	the	DT
cord-260476-whfyczcj	171	10	transport	transport	NN
cord-260476-whfyczcj	171	11	of	of	IN
cord-260476-whfyczcj	171	12	A3	A3	NNP
cord-260476-whfyczcj	171	13	G	G	NNP
cord-260476-whfyczcj	171	14	to	to	IN
cord-260476-whfyczcj	171	15	the	the	DT
cord-260476-whfyczcj	171	16	proteasome	proteasome	NN
cord-260476-whfyczcj	171	17	[	[	-LRB-
cord-260476-whfyczcj	171	18	106	106	CD
cord-260476-whfyczcj	171	19	]	]	-RRB-
cord-260476-whfyczcj	171	20	.	.	.
cord-260476-whfyczcj	172	1	The	the	DT
cord-260476-whfyczcj	172	2	cellular	cellular	JJ
cord-260476-whfyczcj	172	3	protein	protein	NN
cord-260476-whfyczcj	172	4	HDAC6	HDAC6	NNS
cord-260476-whfyczcj	173	1	(	(	-LRB-
cord-260476-whfyczcj	173	2	Histone	Histone	NNP
cord-260476-whfyczcj	173	3	Deacetylase	Deacetylase	NNP
cord-260476-whfyczcj	173	4	6	6	CD
cord-260476-whfyczcj	173	5	)	)	-RRB-
cord-260476-whfyczcj	173	6	has	have	VBZ
cord-260476-whfyczcj	173	7	been	be	VBN
cord-260476-whfyczcj	173	8	shown	show	VBN
cord-260476-whfyczcj	173	9	to	to	TO
cord-260476-whfyczcj	173	10	play	play	VB
cord-260476-whfyczcj	173	11	a	a	DT
cord-260476-whfyczcj	173	12	role	role	NN
cord-260476-whfyczcj	173	13	in	in	IN
cord-260476-whfyczcj	173	14	this	this	DT
cord-260476-whfyczcj	173	15	process	process	NN
cord-260476-whfyczcj	173	16	,	,	,
cord-260476-whfyczcj	173	17	by	by	IN
cord-260476-whfyczcj	173	18	inducing	induce	VBG
cord-260476-whfyczcj	173	19	Vif	Vif	NNP
cord-260476-whfyczcj	173	20	degradation	degradation	NN
cord-260476-whfyczcj	173	21	through	through	IN
cord-260476-whfyczcj	173	22	autophagosomes	autophagosome	NNS
cord-260476-whfyczcj	173	23	as	as	RB
cord-260476-whfyczcj	173	24	well	well	RB
cord-260476-whfyczcj	173	25	as	as	IN
cord-260476-whfyczcj	173	26	by	by	IN
cord-260476-whfyczcj	173	27	protecting	protect	VBG
cord-260476-whfyczcj	173	28	A3	A3	NNP
cord-260476-whfyczcj	173	29	G	g	NN
cord-260476-whfyczcj	173	30	from	from	IN
cord-260476-whfyczcj	173	31	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	173	32	and	and	CC
cord-260476-whfyczcj	173	33	degradation	degradation	NN
cord-260476-whfyczcj	173	34	[	[	-LRB-
cord-260476-whfyczcj	173	35	107	107	CD
cord-260476-whfyczcj	173	36	]	]	-RRB-
cord-260476-whfyczcj	173	37	.	.	.
cord-260476-whfyczcj	174	1	The	the	DT
cord-260476-whfyczcj	174	2	expression	expression	NN
cord-260476-whfyczcj	174	3	level	level	NN
cord-260476-whfyczcj	174	4	of	of	IN
cord-260476-whfyczcj	174	5	Vif	vif	NN
cord-260476-whfyczcj	174	6	is	be	VBZ
cord-260476-whfyczcj	174	7	also	also	RB
cord-260476-whfyczcj	174	8	regulated	regulate	VBN
cord-260476-whfyczcj	174	9	by	by	IN
cord-260476-whfyczcj	174	10	Mdm2	Mdm2	NNP
cord-260476-whfyczcj	174	11	(	(	-LRB-
cord-260476-whfyczcj	174	12	Mouse	Mouse	NNP
cord-260476-whfyczcj	174	13	double	double	JJ
cord-260476-whfyczcj	174	14	minute	minute	JJ
cord-260476-whfyczcj	174	15	2	2	CD
cord-260476-whfyczcj	174	16	homolog	homolog	NN
cord-260476-whfyczcj	174	17	)	)	-RRB-
cord-260476-whfyczcj	174	18	,	,	,
cord-260476-whfyczcj	174	19	an	an	DT
cord-260476-whfyczcj	174	20	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	174	21	ligase	ligase	NN
cord-260476-whfyczcj	174	22	that	that	WDT
cord-260476-whfyczcj	174	23	can	can	MD
cord-260476-whfyczcj	174	24	induce	induce	VB
cord-260476-whfyczcj	174	25	the	the	DT
cord-260476-whfyczcj	174	26	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	174	27	of	of	IN
cord-260476-whfyczcj	174	28	Vif	Vif	NNP
cord-260476-whfyczcj	174	29	and	and	CC
cord-260476-whfyczcj	174	30	its	-PRON-	PRP$
cord-260476-whfyczcj	174	31	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	174	32	degradation	degradation	NN
cord-260476-whfyczcj	174	33	[	[	-LRB-
cord-260476-whfyczcj	174	34	108	108	CD
cord-260476-whfyczcj	174	35	]	]	-RRB-
cord-260476-whfyczcj	174	36	.	.	.
cord-260476-whfyczcj	175	1	CBF	CBF	NNP
cord-260476-whfyczcj	175	2	-	-	HYPH
cord-260476-whfyczcj	175	3	β	β	NNP
cord-260476-whfyczcj	175	4	(	(	-LRB-
cord-260476-whfyczcj	175	5	Core	Core	NNP
cord-260476-whfyczcj	175	6	Binding	Binding	NNP
cord-260476-whfyczcj	175	7	Factor	Factor	NNP
cord-260476-whfyczcj	175	8	β	β	NNP
cord-260476-whfyczcj	175	9	)	)	-RRB-
cord-260476-whfyczcj	175	10	,	,	,
cord-260476-whfyczcj	175	11	a	a	DT
cord-260476-whfyczcj	175	12	co	co	NN
cord-260476-whfyczcj	175	13	-	-	NN
cord-260476-whfyczcj	175	14	factor	factor	NN
cord-260476-whfyczcj	175	15	of	of	IN
cord-260476-whfyczcj	175	16	the	the	DT
cord-260476-whfyczcj	175	17	RUNX	RUNX	NNP
cord-260476-whfyczcj	175	18	transcription	transcription	NN
cord-260476-whfyczcj	175	19	factor	factor	NN
cord-260476-whfyczcj	175	20	family	family	NN
cord-260476-whfyczcj	175	21	,	,	,
cord-260476-whfyczcj	175	22	is	be	VBZ
cord-260476-whfyczcj	175	23	recruited	recruit	VBN
cord-260476-whfyczcj	175	24	by	by	IN
cord-260476-whfyczcj	175	25	Vif	Vif	NNP
cord-260476-whfyczcj	175	26	and	and	CC
cord-260476-whfyczcj	175	27	ensures	ensure	VBZ
cord-260476-whfyczcj	175	28	its	-PRON-	PRP$
cord-260476-whfyczcj	175	29	stability	stability	NN
cord-260476-whfyczcj	175	30	by	by	IN
cord-260476-whfyczcj	175	31	inhibition	inhibition	NN
cord-260476-whfyczcj	175	32	of	of	IN
cord-260476-whfyczcj	175	33	Mdm2	Mdm2	NNP
cord-260476-whfyczcj	175	34	binding	bind	VBG
cord-260476-whfyczcj	175	35	[	[	-LRB-
cord-260476-whfyczcj	175	36	109	109	CD
cord-260476-whfyczcj	175	37	]	]	-RRB-
cord-260476-whfyczcj	175	38	.	.	.
cord-260476-whfyczcj	176	1	CBF	CBF	NNP
cord-260476-whfyczcj	176	2	-	-	HYPH
cord-260476-whfyczcj	176	3	β	β	NNP
cord-260476-whfyczcj	176	4	is	be	VBZ
cord-260476-whfyczcj	176	5	also	also	RB
cord-260476-whfyczcj	176	6	necessary	necessary	JJ
cord-260476-whfyczcj	176	7	to	to	TO
cord-260476-whfyczcj	176	8	allow	allow	VB
cord-260476-whfyczcj	176	9	assembly	assembly	NN
cord-260476-whfyczcj	176	10	of	of	IN
cord-260476-whfyczcj	176	11	the	the	DT
cord-260476-whfyczcj	176	12	SCF	SCF	NNP
cord-260476-whfyczcj	176	13	-	-	HYPH
cord-260476-whfyczcj	176	14	like	like	JJ
cord-260476-whfyczcj	176	15	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	176	16	ligase	ligase	NN
cord-260476-whfyczcj	176	17	mediated	mediate	VBN
cord-260476-whfyczcj	176	18	by	by	IN
cord-260476-whfyczcj	176	19	Vif	Vif	NNP
cord-260476-whfyczcj	176	20	,	,	,
cord-260476-whfyczcj	176	21	resulting	result	VBG
cord-260476-whfyczcj	176	22	in	in	IN
cord-260476-whfyczcj	176	23	the	the	DT
cord-260476-whfyczcj	176	24	inability	inability	NN
cord-260476-whfyczcj	176	25	of	of	IN
cord-260476-whfyczcj	176	26	Vif	Vif	NNP
cord-260476-whfyczcj	176	27	to	to	TO
cord-260476-whfyczcj	176	28	induce	induce	VB
cord-260476-whfyczcj	176	29	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	176	30	and	and	CC
cord-260476-whfyczcj	176	31	degradation	degradation	NN
cord-260476-whfyczcj	176	32	of	of	IN
cord-260476-whfyczcj	176	33	A3	A3	NNP
cord-260476-whfyczcj	176	34	G	G	NNP
cord-260476-whfyczcj	176	35	in	in	IN
cord-260476-whfyczcj	176	36	the	the	DT
cord-260476-whfyczcj	176	37	absence	absence	NN
cord-260476-whfyczcj	176	38	of	of	IN
cord-260476-whfyczcj	176	39	CBF	CBF	NNP
cord-260476-whfyczcj	176	40	-	-	HYPH
cord-260476-whfyczcj	176	41	β	β	NN
cord-260476-whfyczcj	176	42	[	[	-LRB-
cord-260476-whfyczcj	176	43	110	110	CD
cord-260476-whfyczcj	176	44	,	,	,
cord-260476-whfyczcj	176	45	111	111	CD
cord-260476-whfyczcj	176	46	]	]	-RRB-
cord-260476-whfyczcj	176	47	.	.	.
cord-260476-whfyczcj	177	1	Moreover	moreover	RB
cord-260476-whfyczcj	177	2	,	,	,
cord-260476-whfyczcj	177	3	by	by	IN
cord-260476-whfyczcj	177	4	sequestering	sequester	VBG
cord-260476-whfyczcj	177	5	CBF	CBF	NNP
cord-260476-whfyczcj	177	6	-	-	HYPH
cord-260476-whfyczcj	177	7	β	β	NN
cord-260476-whfyczcj	177	8	in	in	IN
cord-260476-whfyczcj	177	9	the	the	DT
cord-260476-whfyczcj	177	10	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	177	11	ligase	ligase	NN
cord-260476-whfyczcj	177	12	complex	complex	NN
cord-260476-whfyczcj	177	13	,	,	,
cord-260476-whfyczcj	177	14	Vif	Vif	NNP
cord-260476-whfyczcj	177	15	indirectly	indirectly	RB
cord-260476-whfyczcj	177	16	causes	cause	VBZ
cord-260476-whfyczcj	177	17	a	a	DT
cord-260476-whfyczcj	177	18	decrease	decrease	NN
cord-260476-whfyczcj	177	19	in	in	IN
cord-260476-whfyczcj	177	20	A3	A3	NNP
cord-260476-whfyczcj	177	21	G	g	NN
cord-260476-whfyczcj	177	22	transcription	transcription	NN
cord-260476-whfyczcj	177	23	as	as	IN
cord-260476-whfyczcj	177	24	the	the	DT
cord-260476-whfyczcj	177	25	A3	A3	NNP
cord-260476-whfyczcj	177	26	G	g	NN
cord-260476-whfyczcj	177	27	gene	gene	NN
cord-260476-whfyczcj	177	28	is	be	VBZ
cord-260476-whfyczcj	177	29	regulated	regulate	VBN
cord-260476-whfyczcj	177	30	by	by	IN
cord-260476-whfyczcj	177	31	the	the	DT
cord-260476-whfyczcj	177	32	RUNX	RUNX	NNP
cord-260476-whfyczcj	177	33	transcription	transcription	NN
cord-260476-whfyczcj	177	34	factor	factor	NN
cord-260476-whfyczcj	177	35	family	family	NN
cord-260476-whfyczcj	177	36	,	,	,
cord-260476-whfyczcj	177	37	which	which	WDT
cord-260476-whfyczcj	177	38	requires	require	VBZ
cord-260476-whfyczcj	177	39	CBF	CBF	NNP
cord-260476-whfyczcj	177	40	-	-	HYPH
cord-260476-whfyczcj	177	41	β	β	NN
cord-260476-whfyczcj	177	42	as	as	IN
cord-260476-whfyczcj	177	43	cofactor	cofactor	NN
cord-260476-whfyczcj	177	44	(	(	-LRB-
cord-260476-whfyczcj	177	45	Figure	figure	NN
cord-260476-whfyczcj	177	46	4C	4c	CD
cord-260476-whfyczcj	177	47	1	1	CD
cord-260476-whfyczcj	177	48	)	)	-RRB-
cord-260476-whfyczcj	178	1	[	[	-LRB-
cord-260476-whfyczcj	178	2	81	81	CD
cord-260476-whfyczcj	178	3	]	]	-RRB-
cord-260476-whfyczcj	178	4	.	.	.
cord-260476-whfyczcj	179	1	Degradation	degradation	NN
cord-260476-whfyczcj	179	2	of	of	IN
cord-260476-whfyczcj	179	3	A3	A3	NNP
cord-260476-whfyczcj	179	4	G	G	NNP
cord-260476-whfyczcj	179	5	through	through	IN
cord-260476-whfyczcj	179	6	the	the	DT
cord-260476-whfyczcj	179	7	UPS	UPS	NNP
cord-260476-whfyczcj	179	8	has	have	VBZ
cord-260476-whfyczcj	179	9	been	be	VBN
cord-260476-whfyczcj	179	10	known	know	VBN
cord-260476-whfyczcj	179	11	for	for	IN
cord-260476-whfyczcj	179	12	a	a	DT
cord-260476-whfyczcj	179	13	long	long	JJ
cord-260476-whfyczcj	179	14	time	time	NN
cord-260476-whfyczcj	179	15	as	as	IN
cord-260476-whfyczcj	179	16	the	the	DT
cord-260476-whfyczcj	179	17	main	main	JJ
cord-260476-whfyczcj	179	18	mechanism	mechanism	NN
cord-260476-whfyczcj	179	19	for	for	IN
cord-260476-whfyczcj	179	20	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	179	21	to	to	TO
cord-260476-whfyczcj	179	22	counteract	counteract	VB
cord-260476-whfyczcj	179	23	cellular	cellular	JJ
cord-260476-whfyczcj	179	24	restriction	restriction	NN
cord-260476-whfyczcj	179	25	;	;	:
cord-260476-whfyczcj	179	26	however	however	RB
cord-260476-whfyczcj	179	27	it	-PRON-	PRP
cord-260476-whfyczcj	179	28	has	have	VBZ
cord-260476-whfyczcj	179	29	been	be	VBN
cord-260476-whfyczcj	179	30	shown	show	VBN
cord-260476-whfyczcj	179	31	that	that	IN
cord-260476-whfyczcj	179	32	Vif	Vif	NNP
cord-260476-whfyczcj	179	33	can	can	MD
cord-260476-whfyczcj	179	34	also	also	RB
cord-260476-whfyczcj	179	35	inhibit	inhibit	VB
cord-260476-whfyczcj	179	36	A3	A3	NNP
cord-260476-whfyczcj	179	37	G	g	NN
cord-260476-whfyczcj	179	38	translation	translation	NN
cord-260476-whfyczcj	179	39	[	[	-LRB-
cord-260476-whfyczcj	179	40	82	82	CD
cord-260476-whfyczcj	179	41	,	,	,
cord-260476-whfyczcj	179	42	112	112	CD
cord-260476-whfyczcj	179	43	,	,	,
cord-260476-whfyczcj	179	44	113	113	CD
cord-260476-whfyczcj	179	45	]	]	-RRB-
cord-260476-whfyczcj	179	46	and	and	CC
cord-260476-whfyczcj	179	47	this	this	DT
cord-260476-whfyczcj	179	48	inhibition	inhibition	NN
cord-260476-whfyczcj	179	49	significantly	significantly	RB
cord-260476-whfyczcj	179	50	contributes	contribute	VBZ
cord-260476-whfyczcj	179	51	to	to	IN
cord-260476-whfyczcj	179	52	the	the	DT
cord-260476-whfyczcj	179	53	counteraction	counteraction	NN
cord-260476-whfyczcj	179	54	mechanism	mechanism	NN
cord-260476-whfyczcj	179	55	(	(	-LRB-
cord-260476-whfyczcj	179	56	Figure	figure	NN
cord-260476-whfyczcj	179	57	4C	4c	CD
cord-260476-whfyczcj	179	58	2	2	CD
cord-260476-whfyczcj	179	59	)	)	-RRB-
cord-260476-whfyczcj	179	60	[	[	-LRB-
cord-260476-whfyczcj	179	61	82	82	CD
cord-260476-whfyczcj	179	62	,	,	,
cord-260476-whfyczcj	179	63	112	112	CD
cord-260476-whfyczcj	179	64	,	,	,
cord-260476-whfyczcj	179	65	113	113	CD
cord-260476-whfyczcj	179	66	]	]	-RRB-
cord-260476-whfyczcj	179	67	.	.	.
cord-260476-whfyczcj	180	1	While	while	IN
cord-260476-whfyczcj	180	2	A3	A3	NNP
cord-260476-whfyczcj	180	3	G	G	NNP
cord-260476-whfyczcj	180	4	is	be	VBZ
cord-260476-whfyczcj	180	5	the	the	DT
cord-260476-whfyczcj	180	6	main	main	JJ
cord-260476-whfyczcj	180	7	member	member	NN
cord-260476-whfyczcj	180	8	of	of	IN
cord-260476-whfyczcj	180	9	the	the	DT
cord-260476-whfyczcj	180	10	A3-family	a3-family	NN
cord-260476-whfyczcj	180	11	that	that	WDT
cord-260476-whfyczcj	180	12	efficiently	efficiently	RB
cord-260476-whfyczcj	180	13	restricts	restrict	VBZ
cord-260476-whfyczcj	180	14	HIV	HIV	NNP
cord-260476-whfyczcj	180	15	,	,	,
cord-260476-whfyczcj	180	16	A3D	A3D	NNP
cord-260476-whfyczcj	180	17	,	,	,
cord-260476-whfyczcj	180	18	F	F	NNP
cord-260476-whfyczcj	180	19	and	and	CC
cord-260476-whfyczcj	180	20	H	H	NNP
cord-260476-whfyczcj	180	21	also	also	RB
cord-260476-whfyczcj	180	22	showed	show	VBD
cord-260476-whfyczcj	180	23	a	a	DT
cord-260476-whfyczcj	180	24	restricting	restrict	VBG
cord-260476-whfyczcj	180	25	activity	activity	NN
cord-260476-whfyczcj	180	26	towards	towards	IN
cord-260476-whfyczcj	180	27	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	180	28	in	in	IN
cord-260476-whfyczcj	180	29	the	the	DT
cord-260476-whfyczcj	180	30	absence	absence	NN
cord-260476-whfyczcj	180	31	of	of	IN
cord-260476-whfyczcj	180	32	Vif	Vif	NNP
cord-260476-whfyczcj	180	33	,	,	,
cord-260476-whfyczcj	180	34	even	even	RB
cord-260476-whfyczcj	180	35	though	though	IN
cord-260476-whfyczcj	180	36	to	to	IN
cord-260476-whfyczcj	180	37	a	a	DT
cord-260476-whfyczcj	180	38	lesser	less	JJR
cord-260476-whfyczcj	180	39	extent	extent	NN
cord-260476-whfyczcj	180	40	than	than	IN
cord-260476-whfyczcj	180	41	A3	A3	NNP
cord-260476-whfyczcj	180	42	G	G	NNP
cord-260476-whfyczcj	180	43	[	[	-LRB-
cord-260476-whfyczcj	180	44	114	114	CD
cord-260476-whfyczcj	180	45	]	]	-RRB-
cord-260476-whfyczcj	180	46	.	.	.
cord-260476-whfyczcj	181	1	Vif	Vif	NNP
cord-260476-whfyczcj	181	2	is	be	VBZ
cord-260476-whfyczcj	181	3	also	also	RB
cord-260476-whfyczcj	181	4	able	able	JJ
cord-260476-whfyczcj	181	5	to	to	TO
cord-260476-whfyczcj	181	6	recruit	recruit	VB
cord-260476-whfyczcj	181	7	these	these	DT
cord-260476-whfyczcj	181	8	A3	A3	NNP
cord-260476-whfyczcj	181	9	proteins	protein	NNS
cord-260476-whfyczcj	181	10	by	by	IN
cord-260476-whfyczcj	181	11	different	different	JJ
cord-260476-whfyczcj	181	12	motifs	motif	NNS
cord-260476-whfyczcj	181	13	of	of	IN
cord-260476-whfyczcj	181	14	its	-PRON-	PRP$
cord-260476-whfyczcj	181	15	N	n	CD
cord-260476-whfyczcj	181	16	-	-	HYPH
cord-260476-whfyczcj	181	17	terminal	terminal	NN
cord-260476-whfyczcj	181	18	domain	domain	NN
cord-260476-whfyczcj	181	19	(	(	-LRB-
cord-260476-whfyczcj	181	20	Figure	figure	NN
cord-260476-whfyczcj	181	21	4B	4b	NN
cord-260476-whfyczcj	181	22	)	)	-RRB-
cord-260476-whfyczcj	181	23	,	,	,
cord-260476-whfyczcj	181	24	thus	thus	RB
cord-260476-whfyczcj	181	25	inducing	induce	VBG
cord-260476-whfyczcj	181	26	their	-PRON-	PRP$
cord-260476-whfyczcj	181	27	degradation	degradation	NN
cord-260476-whfyczcj	181	28	by	by	IN
cord-260476-whfyczcj	181	29	the	the	DT
cord-260476-whfyczcj	181	30	proteasome	proteasome	NN
cord-260476-whfyczcj	181	31	similarly	similarly	RB
cord-260476-whfyczcj	181	32	to	to	IN
cord-260476-whfyczcj	181	33	A3	A3	NNP
cord-260476-whfyczcj	181	34	G	G	NNP
cord-260476-whfyczcj	181	35	[	[	-LRB-
cord-260476-whfyczcj	181	36	115	115	CD
cord-260476-whfyczcj	181	37	]	]	-RRB-
cord-260476-whfyczcj	181	38	[	[	-LRB-
cord-260476-whfyczcj	181	39	116	116	CD
cord-260476-whfyczcj	181	40	]	]	-RRB-
cord-260476-whfyczcj	181	41	[	[	-LRB-
cord-260476-whfyczcj	181	42	117	117	CD
cord-260476-whfyczcj	181	43	]	]	-RRB-
cord-260476-whfyczcj	181	44	.	.	.
cord-260476-whfyczcj	182	1	translation	translation	NN
cord-260476-whfyczcj	182	2	[	[	-LRB-
cord-260476-whfyczcj	182	3	82	82	CD
cord-260476-whfyczcj	182	4	,	,	,
cord-260476-whfyczcj	182	5	112	112	CD
cord-260476-whfyczcj	182	6	,	,	,
cord-260476-whfyczcj	182	7	113	113	CD
cord-260476-whfyczcj	182	8	]	]	-RRB-
cord-260476-whfyczcj	182	9	and	and	CC
cord-260476-whfyczcj	183	1	this	this	DT
cord-260476-whfyczcj	183	2	inhibition	inhibition	NN
cord-260476-whfyczcj	183	3	significantly	significantly	RB
cord-260476-whfyczcj	183	4	contributes	contribute	VBZ
cord-260476-whfyczcj	183	5	to	to	IN
cord-260476-whfyczcj	183	6	the	the	DT
cord-260476-whfyczcj	183	7	counteraction	counteraction	NN
cord-260476-whfyczcj	183	8	mechanism	mechanism	NN
cord-260476-whfyczcj	183	9	(	(	-LRB-
cord-260476-whfyczcj	183	10	Figure	figure	NN
cord-260476-whfyczcj	183	11	4C	4c	CD
cord-260476-whfyczcj	183	12	)	)	-RRB-
cord-260476-whfyczcj	183	13	[	[	-LRB-
cord-260476-whfyczcj	183	14	82	82	CD
cord-260476-whfyczcj	183	15	,	,	,
cord-260476-whfyczcj	183	16	112	112	CD
cord-260476-whfyczcj	183	17	,	,	,
cord-260476-whfyczcj	183	18	113	113	CD
cord-260476-whfyczcj	183	19	]	]	-RRB-
cord-260476-whfyczcj	183	20	.	.	.
cord-260476-whfyczcj	184	1	While	while	IN
cord-260476-whfyczcj	184	2	A3	A3	NNP
cord-260476-whfyczcj	184	3	G	G	NNP
cord-260476-whfyczcj	184	4	is	be	VBZ
cord-260476-whfyczcj	184	5	the	the	DT
cord-260476-whfyczcj	184	6	main	main	JJ
cord-260476-whfyczcj	184	7	member	member	NN
cord-260476-whfyczcj	184	8	of	of	IN
cord-260476-whfyczcj	184	9	the	the	DT
cord-260476-whfyczcj	184	10	A3-family	a3-family	NN
cord-260476-whfyczcj	184	11	that	that	WDT
cord-260476-whfyczcj	184	12	efficiently	efficiently	RB
cord-260476-whfyczcj	184	13	restricts	restrict	VBZ
cord-260476-whfyczcj	184	14	HIV	HIV	NNP
cord-260476-whfyczcj	184	15	,	,	,
cord-260476-whfyczcj	184	16	A3D	A3D	NNP
cord-260476-whfyczcj	184	17	,	,	,
cord-260476-whfyczcj	184	18	F	F	NNP
cord-260476-whfyczcj	184	19	and	and	CC
cord-260476-whfyczcj	184	20	H	H	NNP
cord-260476-whfyczcj	184	21	also	also	RB
cord-260476-whfyczcj	184	22	showed	show	VBD
cord-260476-whfyczcj	184	23	a	a	DT
cord-260476-whfyczcj	184	24	restricting	restrict	VBG
cord-260476-whfyczcj	184	25	activity	activity	NN
cord-260476-whfyczcj	184	26	towards	towards	IN
cord-260476-whfyczcj	184	27	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	184	28	in	in	IN
cord-260476-whfyczcj	184	29	the	the	DT
cord-260476-whfyczcj	184	30	absence	absence	NN
cord-260476-whfyczcj	184	31	of	of	IN
cord-260476-whfyczcj	184	32	Vif	Vif	NNP
cord-260476-whfyczcj	184	33	,	,	,
cord-260476-whfyczcj	184	34	even	even	RB
cord-260476-whfyczcj	184	35	though	though	IN
cord-260476-whfyczcj	184	36	to	to	IN
cord-260476-whfyczcj	184	37	a	a	DT
cord-260476-whfyczcj	184	38	lesser	less	JJR
cord-260476-whfyczcj	184	39	extent	extent	NN
cord-260476-whfyczcj	184	40	than	than	IN
cord-260476-whfyczcj	184	41	A3	A3	NNP
cord-260476-whfyczcj	184	42	G	G	NNP
cord-260476-whfyczcj	184	43	[	[	-LRB-
cord-260476-whfyczcj	184	44	114	114	CD
cord-260476-whfyczcj	184	45	]	]	-RRB-
cord-260476-whfyczcj	184	46	.	.	.
cord-260476-whfyczcj	185	1	Vif	Vif	NNP
cord-260476-whfyczcj	185	2	is	be	VBZ
cord-260476-whfyczcj	185	3	also	also	RB
cord-260476-whfyczcj	185	4	able	able	JJ
cord-260476-whfyczcj	185	5	to	to	TO
cord-260476-whfyczcj	185	6	recruit	recruit	VB
cord-260476-whfyczcj	185	7	these	these	DT
cord-260476-whfyczcj	185	8	A3	A3	NNP
cord-260476-whfyczcj	185	9	proteins	protein	NNS
cord-260476-whfyczcj	185	10	by	by	IN
cord-260476-whfyczcj	185	11	different	different	JJ
cord-260476-whfyczcj	185	12	motifs	motif	NNS
cord-260476-whfyczcj	185	13	of	of	IN
cord-260476-whfyczcj	185	14	its	-PRON-	PRP$
cord-260476-whfyczcj	185	15	N	n	CD
cord-260476-whfyczcj	185	16	-	-	HYPH
cord-260476-whfyczcj	185	17	terminal	terminal	NN
cord-260476-whfyczcj	185	18	domain	domain	NN
cord-260476-whfyczcj	185	19	(	(	-LRB-
cord-260476-whfyczcj	185	20	Figure	figure	NN
cord-260476-whfyczcj	185	21	4B	4b	NN
cord-260476-whfyczcj	185	22	)	)	-RRB-
cord-260476-whfyczcj	185	23	,	,	,
cord-260476-whfyczcj	185	24	thus	thus	RB
cord-260476-whfyczcj	185	25	inducing	induce	VBG
cord-260476-whfyczcj	185	26	their	-PRON-	PRP$
cord-260476-whfyczcj	185	27	degradation	degradation	NN
cord-260476-whfyczcj	185	28	by	by	IN
cord-260476-whfyczcj	185	29	the	the	DT
cord-260476-whfyczcj	185	30	proteasome	proteasome	NN
cord-260476-whfyczcj	185	31	similarly	similarly	RB
cord-260476-whfyczcj	185	32	to	to	IN
cord-260476-whfyczcj	185	33	A3	A3	NNP
cord-260476-whfyczcj	185	34	G	G	NNP
cord-260476-whfyczcj	185	35	[	[	-LRB-
cord-260476-whfyczcj	185	36	115	115	CD
cord-260476-whfyczcj	185	37	]	]	-RRB-
cord-260476-whfyczcj	185	38	[	[	-LRB-
cord-260476-whfyczcj	185	39	116	116	CD
cord-260476-whfyczcj	185	40	]	]	-RRB-
cord-260476-whfyczcj	185	41	[	[	-LRB-
cord-260476-whfyczcj	185	42	117	117	CD
cord-260476-whfyczcj	185	43	]	]	-RRB-
cord-260476-whfyczcj	185	44	.	.	.
cord-260476-whfyczcj	185	45	 	 	_SP
cord-260476-whfyczcj	186	1	Sterile	sterile	JJ
cord-260476-whfyczcj	186	2	alpha	alpha	NN
cord-260476-whfyczcj	186	3	motif	motif	NN
cord-260476-whfyczcj	186	4	and	and	CC
cord-260476-whfyczcj	186	5	histidine	histidine	NN
cord-260476-whfyczcj	186	6	-	-	HYPH
cord-260476-whfyczcj	186	7	aspartate	aspartate	NN
cord-260476-whfyczcj	186	8	domain	domain	NN
cord-260476-whfyczcj	186	9	-	-	HYPH
cord-260476-whfyczcj	186	10	containing	contain	VBG
cord-260476-whfyczcj	186	11	protein	protein	NN
cord-260476-whfyczcj	186	12	1	1	CD
cord-260476-whfyczcj	186	13	(	(	-LRB-
cord-260476-whfyczcj	186	14	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	186	15	,	,	,
cord-260476-whfyczcj	186	16	Figure	figure	NN
cord-260476-whfyczcj	186	17	5A	5a	NN
cord-260476-whfyczcj	186	18	)	)	-RRB-
cord-260476-whfyczcj	186	19	is	be	VBZ
cord-260476-whfyczcj	186	20	a	a	DT
cord-260476-whfyczcj	186	21	dGTP	dgtp	NN
cord-260476-whfyczcj	186	22	-	-	HYPH
cord-260476-whfyczcj	186	23	regulated	regulate	VBN
cord-260476-whfyczcj	186	24	deoxynucleoside	deoxynucleoside	JJ
cord-260476-whfyczcj	186	25	-	-	HYPH
cord-260476-whfyczcj	186	26	triphosphohydrolase	triphosphohydrolase	NN
cord-260476-whfyczcj	186	27	that	that	WDT
cord-260476-whfyczcj	186	28	catalyzes	catalyze	VBZ
cord-260476-whfyczcj	186	29	the	the	DT
cord-260476-whfyczcj	186	30	hydrolysis	hydrolysis	NN
cord-260476-whfyczcj	186	31	of	of	IN
cord-260476-whfyczcj	186	32	dNTPs	dntps	CD
cord-260476-whfyczcj	186	33	to	to	IN
cord-260476-whfyczcj	186	34	deoxynucleosides	deoxynucleoside	NNS
cord-260476-whfyczcj	186	35	and	and	CC
cord-260476-whfyczcj	186	36	inorganic	inorganic	JJ
cord-260476-whfyczcj	186	37	triphosphate	triphosphate	NN
cord-260476-whfyczcj	186	38	[	[	-LRB-
cord-260476-whfyczcj	186	39	118	118	CD
cord-260476-whfyczcj	186	40	,	,	,
cord-260476-whfyczcj	186	41	119	119	CD
cord-260476-whfyczcj	186	42	]	]	-RRB-
cord-260476-whfyczcj	186	43	.	.	.
cord-260476-whfyczcj	187	1	In	in	IN
cord-260476-whfyczcj	187	2	non	non	JJ
cord-260476-whfyczcj	187	3	-	-	JJ
cord-260476-whfyczcj	187	4	cycling	cycling	JJ
cord-260476-whfyczcj	187	5	myeloid	myeloid	NN
cord-260476-whfyczcj	187	6	cells	cell	NNS
cord-260476-whfyczcj	187	7	as	as	RB
cord-260476-whfyczcj	187	8	well	well	RB
cord-260476-whfyczcj	187	9	as	as	IN
cord-260476-whfyczcj	187	10	in	in	IN
cord-260476-whfyczcj	187	11	resting	rest	VBG
cord-260476-whfyczcj	187	12	CD4	CD4	NNP
cord-260476-whfyczcj	187	13	+	+	CC
cord-260476-whfyczcj	187	14	T	t	NN
cord-260476-whfyczcj	187	15	cells	cell	NNS
cord-260476-whfyczcj	187	16	,	,	,
cord-260476-whfyczcj	187	17	this	this	DT
cord-260476-whfyczcj	187	18	restriction	restriction	NN
cord-260476-whfyczcj	187	19	factor	factor	NN
cord-260476-whfyczcj	187	20	causes	cause	VBZ
cord-260476-whfyczcj	187	21	a	a	DT
cord-260476-whfyczcj	187	22	block	block	NN
cord-260476-whfyczcj	187	23	in	in	IN
cord-260476-whfyczcj	187	24	the	the	DT
cord-260476-whfyczcj	187	25	early	early	JJ
cord-260476-whfyczcj	187	26	steps	step	NNS
cord-260476-whfyczcj	187	27	of	of	IN
cord-260476-whfyczcj	187	28	the	the	DT
cord-260476-whfyczcj	187	29	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	187	30	life	life	NN
cord-260476-whfyczcj	187	31	cycle	cycle	NN
cord-260476-whfyczcj	187	32	[	[	-LRB-
cord-260476-whfyczcj	187	33	67	67	CD
cord-260476-whfyczcj	187	34	]	]	-RRB-
cord-260476-whfyczcj	187	35	by	by	IN
cord-260476-whfyczcj	187	36	depleting	deplete	VBG
cord-260476-whfyczcj	187	37	the	the	DT
cord-260476-whfyczcj	187	38	intracellular	intracellular	JJ
cord-260476-whfyczcj	187	39	pool	pool	NN
cord-260476-whfyczcj	187	40	of	of	IN
cord-260476-whfyczcj	187	41	dNTPs	dntps	CD
cord-260476-whfyczcj	187	42	[	[	-LRB-
cord-260476-whfyczcj	187	43	68	68	CD
cord-260476-whfyczcj	187	44	]	]	-RRB-
cord-260476-whfyczcj	187	45	,	,	,
cord-260476-whfyczcj	187	46	which	which	WDT
cord-260476-whfyczcj	187	47	leads	lead	VBZ
cord-260476-whfyczcj	187	48	to	to	IN
cord-260476-whfyczcj	187	49	abortion	abortion	NN
cord-260476-whfyczcj	187	50	of	of	IN
cord-260476-whfyczcj	187	51	the	the	DT
cord-260476-whfyczcj	187	52	viral	viral	JJ
cord-260476-whfyczcj	187	53	genomic	genomic	JJ
cord-260476-whfyczcj	187	54	RNA	RNA	NNP
cord-260476-whfyczcj	187	55	reverse	reverse	NN
cord-260476-whfyczcj	187	56	transcription	transcription	NN
cord-260476-whfyczcj	187	57	and	and	CC
cord-260476-whfyczcj	187	58	accumulation	accumulation	NN
cord-260476-whfyczcj	187	59	of	of	IN
cord-260476-whfyczcj	187	60	defective	defective	JJ
cord-260476-whfyczcj	187	61	viral	viral	JJ
cord-260476-whfyczcj	187	62	cDNA	cdna	NN
cord-260476-whfyczcj	187	63	(	(	-LRB-
cord-260476-whfyczcj	187	64	Figure	figure	NN
cord-260476-whfyczcj	187	65	5C	5c	CD
cord-260476-whfyczcj	187	66	)	)	-RRB-
cord-260476-whfyczcj	187	67	[	[	-LRB-
cord-260476-whfyczcj	187	68	120	120	CD
cord-260476-whfyczcj	187	69	]	]	-RRB-
cord-260476-whfyczcj	187	70	.	.	.
cord-260476-whfyczcj	188	1	This	this	DT
cord-260476-whfyczcj	188	2	block	block	NN
cord-260476-whfyczcj	188	3	strongly	strongly	RB
cord-260476-whfyczcj	188	4	(	(	-LRB-
cord-260476-whfyczcj	188	5	C	C	NNP
cord-260476-whfyczcj	188	6	)	)	-RRB-
cord-260476-whfyczcj	189	1	the	the	DT
cord-260476-whfyczcj	189	2	mechanism	mechanism	NN
cord-260476-whfyczcj	189	3	of	of	IN
cord-260476-whfyczcj	189	4	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	189	5	G	g	NN
cord-260476-whfyczcj	189	6	restriction	restriction	NN
cord-260476-whfyczcj	189	7	and	and	CC
cord-260476-whfyczcj	189	8	Vif	Vif	NNP
cord-260476-whfyczcj	189	9	counteraction	counteraction	NN
cord-260476-whfyczcj	189	10	.	.	.
cord-260476-whfyczcj	190	1	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	190	2	G	G	NNP
cord-260476-whfyczcj	190	3	(	(	-LRB-
cord-260476-whfyczcj	190	4	red	red	NNP
cord-260476-whfyczcj	190	5	)	)	-RRB-
cord-260476-whfyczcj	190	6	is	be	VBZ
cord-260476-whfyczcj	190	7	incorporated	incorporate	VBN
cord-260476-whfyczcj	190	8	into	into	IN
cord-260476-whfyczcj	190	9	virions	virion	NNS
cord-260476-whfyczcj	190	10	and	and	CC
cord-260476-whfyczcj	190	11	induces	induce	VBZ
cord-260476-whfyczcj	190	12	hypermutations	hypermutation	NNS
cord-260476-whfyczcj	190	13	of	of	IN
cord-260476-whfyczcj	190	14	the	the	DT
cord-260476-whfyczcj	190	15	provirus	provirus	NNP
cord-260476-whfyczcj	190	16	leading	lead	VBG
cord-260476-whfyczcj	190	17	either	either	CC
cord-260476-whfyczcj	190	18	to	to	IN
cord-260476-whfyczcj	190	19	its	-PRON-	PRP$
cord-260476-whfyczcj	190	20	degradation	degradation	NN
cord-260476-whfyczcj	190	21	or	or	CC
cord-260476-whfyczcj	190	22	production	production	NN
cord-260476-whfyczcj	190	23	of	of	IN
cord-260476-whfyczcj	190	24	truncated	truncated	JJ
cord-260476-whfyczcj	190	25	viral	viral	JJ
cord-260476-whfyczcj	190	26	proteins	protein	NNS
cord-260476-whfyczcj	190	27	.	.	.
cord-260476-whfyczcj	191	1	Vif	Vif	NNP
cord-260476-whfyczcj	191	2	(	(	-LRB-
cord-260476-whfyczcj	191	3	blue	blue	NNP
cord-260476-whfyczcj	191	4	)	)	-RRB-
cord-260476-whfyczcj	191	5	decreases	decrease	VBZ
cord-260476-whfyczcj	191	6	A3	A3	NNP
cord-260476-whfyczcj	191	7	G	g	NN
cord-260476-whfyczcj	191	8	transcription	transcription	NN
cord-260476-whfyczcj	191	9	1	1	CD
cord-260476-whfyczcj	191	10	,	,	,
cord-260476-whfyczcj	191	11	inhibits	inhibit	VBZ
cord-260476-whfyczcj	191	12	its	-PRON-	PRP$
cord-260476-whfyczcj	191	13	translation	translation	NN
cord-260476-whfyczcj	191	14	2	2	CD
cord-260476-whfyczcj	191	15	(	(	-LRB-
cord-260476-whfyczcj	191	16	Red	Red	NNP
cord-260476-whfyczcj	191	17	T	T	NNP
cord-260476-whfyczcj	191	18	bar	bar	NN
cord-260476-whfyczcj	191	19	)	)	-RRB-
cord-260476-whfyczcj	191	20	and	and	CC
cord-260476-whfyczcj	191	21	induces	induce	VBZ
cord-260476-whfyczcj	191	22	its	-PRON-	PRP$
cord-260476-whfyczcj	191	23	degradation	degradation	NN
cord-260476-whfyczcj	191	24	by	by	IN
cord-260476-whfyczcj	191	25	the	the	DT
cord-260476-whfyczcj	191	26	proteasome	proteasome	NN
cord-260476-whfyczcj	191	27	3	3	CD
cord-260476-whfyczcj	191	28	.	.	.
cord-260476-whfyczcj	192	1	Sterile	sterile	JJ
cord-260476-whfyczcj	192	2	alpha	alpha	NN
cord-260476-whfyczcj	192	3	motif	motif	NN
cord-260476-whfyczcj	192	4	and	and	CC
cord-260476-whfyczcj	192	5	histidine	histidine	NN
cord-260476-whfyczcj	192	6	-	-	HYPH
cord-260476-whfyczcj	192	7	aspartate	aspartate	NN
cord-260476-whfyczcj	192	8	domain	domain	NN
cord-260476-whfyczcj	192	9	-	-	HYPH
cord-260476-whfyczcj	192	10	containing	contain	VBG
cord-260476-whfyczcj	192	11	protein	protein	NN
cord-260476-whfyczcj	192	12	1	1	CD
cord-260476-whfyczcj	192	13	(	(	-LRB-
cord-260476-whfyczcj	192	14	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	192	15	,	,	,
cord-260476-whfyczcj	192	16	Figure	figure	NN
cord-260476-whfyczcj	192	17	5A	5a	NN
cord-260476-whfyczcj	192	18	)	)	-RRB-
cord-260476-whfyczcj	192	19	is	be	VBZ
cord-260476-whfyczcj	192	20	a	a	DT
cord-260476-whfyczcj	192	21	dGTP	dgtp	NN
cord-260476-whfyczcj	192	22	-	-	HYPH
cord-260476-whfyczcj	192	23	regulated	regulate	VBN
cord-260476-whfyczcj	192	24	deoxynucleoside	deoxynucleoside	JJ
cord-260476-whfyczcj	192	25	-	-	HYPH
cord-260476-whfyczcj	192	26	triphosphohydrolase	triphosphohydrolase	NN
cord-260476-whfyczcj	192	27	that	that	WDT
cord-260476-whfyczcj	192	28	catalyzes	catalyze	VBZ
cord-260476-whfyczcj	192	29	the	the	DT
cord-260476-whfyczcj	192	30	hydrolysis	hydrolysis	NN
cord-260476-whfyczcj	192	31	of	of	IN
cord-260476-whfyczcj	192	32	dNTPs	dntps	CD
cord-260476-whfyczcj	192	33	to	to	IN
cord-260476-whfyczcj	192	34	deoxynucleosides	deoxynucleoside	NNS
cord-260476-whfyczcj	192	35	and	and	CC
cord-260476-whfyczcj	192	36	inorganic	inorganic	JJ
cord-260476-whfyczcj	192	37	triphosphate	triphosphate	NN
cord-260476-whfyczcj	192	38	[	[	-LRB-
cord-260476-whfyczcj	192	39	118	118	CD
cord-260476-whfyczcj	192	40	,	,	,
cord-260476-whfyczcj	192	41	119	119	CD
cord-260476-whfyczcj	192	42	]	]	-RRB-
cord-260476-whfyczcj	192	43	.	.	.
cord-260476-whfyczcj	193	1	In	in	IN
cord-260476-whfyczcj	193	2	non	non	JJ
cord-260476-whfyczcj	193	3	-	-	JJ
cord-260476-whfyczcj	193	4	cycling	cycling	JJ
cord-260476-whfyczcj	193	5	myeloid	myeloid	NN
cord-260476-whfyczcj	193	6	cells	cell	NNS
cord-260476-whfyczcj	193	7	as	as	RB
cord-260476-whfyczcj	193	8	well	well	RB
cord-260476-whfyczcj	193	9	as	as	IN
cord-260476-whfyczcj	193	10	in	in	IN
cord-260476-whfyczcj	193	11	resting	rest	VBG
cord-260476-whfyczcj	193	12	CD4	CD4	NNP
cord-260476-whfyczcj	193	13	+	+	CC
cord-260476-whfyczcj	193	14	T	t	NN
cord-260476-whfyczcj	193	15	cells	cell	NNS
cord-260476-whfyczcj	193	16	,	,	,
cord-260476-whfyczcj	193	17	this	this	DT
cord-260476-whfyczcj	193	18	restriction	restriction	NN
cord-260476-whfyczcj	193	19	factor	factor	NN
cord-260476-whfyczcj	193	20	causes	cause	VBZ
cord-260476-whfyczcj	193	21	a	a	DT
cord-260476-whfyczcj	193	22	block	block	NN
cord-260476-whfyczcj	193	23	in	in	IN
cord-260476-whfyczcj	193	24	the	the	DT
cord-260476-whfyczcj	193	25	early	early	JJ
cord-260476-whfyczcj	193	26	steps	step	NNS
cord-260476-whfyczcj	193	27	of	of	IN
cord-260476-whfyczcj	193	28	the	the	DT
cord-260476-whfyczcj	193	29	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	193	30	life	life	NN
cord-260476-whfyczcj	193	31	cycle	cycle	NN
cord-260476-whfyczcj	193	32	[	[	-LRB-
cord-260476-whfyczcj	193	33	67	67	CD
cord-260476-whfyczcj	193	34	]	]	-RRB-
cord-260476-whfyczcj	193	35	by	by	IN
cord-260476-whfyczcj	193	36	depleting	deplete	VBG
cord-260476-whfyczcj	193	37	the	the	DT
cord-260476-whfyczcj	193	38	intracellular	intracellular	JJ
cord-260476-whfyczcj	193	39	pool	pool	NN
cord-260476-whfyczcj	193	40	of	of	IN
cord-260476-whfyczcj	193	41	dNTPs	dntps	CD
cord-260476-whfyczcj	193	42	[	[	-LRB-
cord-260476-whfyczcj	193	43	68	68	CD
cord-260476-whfyczcj	193	44	]	]	-RRB-
cord-260476-whfyczcj	193	45	,	,	,
cord-260476-whfyczcj	193	46	which	which	WDT
cord-260476-whfyczcj	193	47	leads	lead	VBZ
cord-260476-whfyczcj	193	48	to	to	IN
cord-260476-whfyczcj	193	49	abortion	abortion	NN
cord-260476-whfyczcj	193	50	of	of	IN
cord-260476-whfyczcj	193	51	the	the	DT
cord-260476-whfyczcj	193	52	viral	viral	JJ
cord-260476-whfyczcj	193	53	genomic	genomic	JJ
cord-260476-whfyczcj	193	54	RNA	RNA	NNP
cord-260476-whfyczcj	193	55	reverse	reverse	NN
cord-260476-whfyczcj	193	56	transcription	transcription	NN
cord-260476-whfyczcj	193	57	and	and	CC
cord-260476-whfyczcj	193	58	accumulation	accumulation	NN
cord-260476-whfyczcj	193	59	of	of	IN
cord-260476-whfyczcj	193	60	defective	defective	JJ
cord-260476-whfyczcj	193	61	viral	viral	JJ
cord-260476-whfyczcj	193	62	cDNA	cdna	NN
cord-260476-whfyczcj	193	63	(	(	-LRB-
cord-260476-whfyczcj	193	64	Figure	figure	NN
cord-260476-whfyczcj	193	65	5C	5c	CD
cord-260476-whfyczcj	193	66	)	)	-RRB-
cord-260476-whfyczcj	193	67	[	[	-LRB-
cord-260476-whfyczcj	193	68	120	120	CD
cord-260476-whfyczcj	193	69	]	]	-RRB-
cord-260476-whfyczcj	193	70	.	.	.
cord-260476-whfyczcj	194	1	This	this	DT
cord-260476-whfyczcj	194	2	block	block	NN
cord-260476-whfyczcj	194	3	strongly	strongly	RB
cord-260476-whfyczcj	194	4	affects	affect	VBZ
cord-260476-whfyczcj	194	5	infectivity	infectivity	NN
cord-260476-whfyczcj	194	6	of	of	IN
cord-260476-whfyczcj	194	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	194	8	in	in	IN
cord-260476-whfyczcj	194	9	these	these	DT
cord-260476-whfyczcj	194	10	cell	cell	NN
cord-260476-whfyczcj	194	11	types	type	NNS
cord-260476-whfyczcj	194	12	but	but	CC
cord-260476-whfyczcj	194	13	has	have	VBZ
cord-260476-whfyczcj	194	14	no	no	DT
cord-260476-whfyczcj	194	15	effect	effect	NN
cord-260476-whfyczcj	194	16	on	on	IN
cord-260476-whfyczcj	194	17	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	194	18	infectivity	infectivity	NN
cord-260476-whfyczcj	194	19	[	[	-LRB-
cord-260476-whfyczcj	194	20	121	121	CD
cord-260476-whfyczcj	194	21	]	]	-RRB-
cord-260476-whfyczcj	194	22	.	.	.
cord-260476-whfyczcj	195	1	Indeed	indeed	RB
cord-260476-whfyczcj	195	2	,	,	,
cord-260476-whfyczcj	195	3	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	195	4	possesses	possess	VBZ
cord-260476-whfyczcj	195	5	the	the	DT
cord-260476-whfyczcj	195	6	viral	viral	JJ
cord-260476-whfyczcj	195	7	protein	protein	NN
cord-260476-whfyczcj	195	8	X	x	NN
cord-260476-whfyczcj	195	9	(	(	-LRB-
cord-260476-whfyczcj	195	10	Vpx	Vpx	NNP
cord-260476-whfyczcj	195	11	,	,	,
cord-260476-whfyczcj	195	12	Figure	figure	NN
cord-260476-whfyczcj	195	13	5B	5b	NN
cord-260476-whfyczcj	195	14	)	)	-RRB-
cord-260476-whfyczcj	195	15	which	which	WDT
cord-260476-whfyczcj	195	16	alleviates	alleviate	VBZ
cord-260476-whfyczcj	195	17	the	the	DT
cord-260476-whfyczcj	195	18	post	post	JJ
cord-260476-whfyczcj	195	19	-	-	JJ
cord-260476-whfyczcj	195	20	entry	entry	JJ
cord-260476-whfyczcj	195	21	block	block	NN
cord-260476-whfyczcj	195	22	mediated	mediate	VBN
cord-260476-whfyczcj	195	23	by	by	IN
cord-260476-whfyczcj	195	24	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	195	25	by	by	IN
cord-260476-whfyczcj	195	26	inducing	induce	VBG
cord-260476-whfyczcj	195	27	its	-PRON-	PRP$
cord-260476-whfyczcj	195	28	degradation	degradation	NN
cord-260476-whfyczcj	195	29	by	by	IN
cord-260476-whfyczcj	195	30	the	the	DT
cord-260476-whfyczcj	195	31	proteasome	proteasome	NN
cord-260476-whfyczcj	195	32	.	.	.
cord-260476-whfyczcj	196	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	196	2	has	have	VBZ
cord-260476-whfyczcj	196	3	been	be	VBN
cord-260476-whfyczcj	196	4	found	find	VBN
cord-260476-whfyczcj	196	5	to	to	TO
cord-260476-whfyczcj	196	6	recruit	recruit	VB
cord-260476-whfyczcj	196	7	the	the	DT
cord-260476-whfyczcj	196	8	CUL4A	cul4a	NN
cord-260476-whfyczcj	196	9	-	-	HYPH
cord-260476-whfyczcj	196	10	DDB1-DCAF1(DDB1	DDB1-DCAF1(DDB1	NNP
cord-260476-whfyczcj	196	11	and	and	CC
cord-260476-whfyczcj	196	12	CUL4	CUL4	NNP
cord-260476-whfyczcj	196	13	Associated	Associated	NNP
cord-260476-whfyczcj	196	14	Factor	Factor	NNP
cord-260476-whfyczcj	196	15	1	1	CD
cord-260476-whfyczcj	196	16	)	)	-RRB-
cord-260476-whfyczcj	196	17	E3	e3	NN
cord-260476-whfyczcj	196	18	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	196	19	ligase	ligase	NN
cord-260476-whfyczcj	196	20	through	through	IN
cord-260476-whfyczcj	196	21	a	a	DT
cord-260476-whfyczcj	196	22	direct	direct	JJ
cord-260476-whfyczcj	196	23	interaction	interaction	NN
cord-260476-whfyczcj	196	24	with	with	IN
cord-260476-whfyczcj	196	25	its	-PRON-	PRP$
cord-260476-whfyczcj	196	26	substrate	substrate	NN
cord-260476-whfyczcj	196	27	recognition	recognition	NN
cord-260476-whfyczcj	196	28	protein	protein	NN
cord-260476-whfyczcj	196	29	DCAF1	DCAF1	NNP
cord-260476-whfyczcj	197	1	(	(	-LRB-
cord-260476-whfyczcj	197	2	DDB1	DDB1	NNP
cord-260476-whfyczcj	197	3	and	and	CC
cord-260476-whfyczcj	197	4	CUL4	CUL4	NNP
cord-260476-whfyczcj	197	5	Associated	Associated	NNP
cord-260476-whfyczcj	197	6	Factor	Factor	NNP
cord-260476-whfyczcj	197	7	1	1	CD
cord-260476-whfyczcj	197	8	)	)	-RRB-
cord-260476-whfyczcj	197	9	[	[	-LRB-
cord-260476-whfyczcj	197	10	122	122	CD
cord-260476-whfyczcj	197	11	]	]	-RRB-
cord-260476-whfyczcj	197	12	while	while	IN
cord-260476-whfyczcj	197	13	also	also	RB
cord-260476-whfyczcj	197	14	interacting	interact	VBG
cord-260476-whfyczcj	197	15	with	with	IN
cord-260476-whfyczcj	197	16	the	the	DT
cord-260476-whfyczcj	197	17	C	C	NNP
cord-260476-whfyczcj	197	18	-	-	HYPH
cord-260476-whfyczcj	197	19	terminal	terminal	NN
cord-260476-whfyczcj	197	20	domain	domain	NN
cord-260476-whfyczcj	197	21	of	of	IN
cord-260476-whfyczcj	197	22	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	197	23	,	,	,
cord-260476-whfyczcj	197	24	thereby	thereby	RB
cord-260476-whfyczcj	197	25	loading	load	VBG
cord-260476-whfyczcj	197	26	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	197	27	onto	onto	IN
cord-260476-whfyczcj	197	28	the	the	DT
cord-260476-whfyczcj	197	29	E3	E3	NNP
cord-260476-whfyczcj	197	30	complex	complex	NN
cord-260476-whfyczcj	197	31	and	and	CC
cord-260476-whfyczcj	197	32	inducing	induce	VBG
cord-260476-whfyczcj	197	33	its	-PRON-	PRP$
cord-260476-whfyczcj	197	34	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	197	35	followed	follow	VBN
cord-260476-whfyczcj	197	36	by	by	IN
cord-260476-whfyczcj	197	37	its	-PRON-	PRP$
cord-260476-whfyczcj	197	38	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	197	39	degradation	degradation	NN
cord-260476-whfyczcj	197	40	(	(	-LRB-
cord-260476-whfyczcj	197	41	Figure	figure	NN
cord-260476-whfyczcj	197	42	5C	5c	CD
cord-260476-whfyczcj	197	43	)	)	-RRB-
cord-260476-whfyczcj	197	44	.	.	.
cord-260476-whfyczcj	198	1	The	the	DT
cord-260476-whfyczcj	198	2	nuclear	nuclear	JJ
cord-260476-whfyczcj	198	3	localization	localization	NN
cord-260476-whfyczcj	198	4	of	of	IN
cord-260476-whfyczcj	198	5	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	198	6	is	be	VBZ
cord-260476-whfyczcj	198	7	required	require	VBN
cord-260476-whfyczcj	198	8	for	for	IN
cord-260476-whfyczcj	198	9	its	-PRON-	PRP$
cord-260476-whfyczcj	198	10	Vpx	Vpx	NNP
cord-260476-whfyczcj	198	11	-	-	HYPH
cord-260476-whfyczcj	198	12	induced	induce	VBN
cord-260476-whfyczcj	198	13	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	198	14	degradation	degradation	NN
cord-260476-whfyczcj	198	15	,	,	,
cord-260476-whfyczcj	198	16	suggesting	suggest	VBG
cord-260476-whfyczcj	198	17	the	the	DT
cord-260476-whfyczcj	198	18	nuclear	nuclear	JJ
cord-260476-whfyczcj	198	19	UPS	UPS	NNP
cord-260476-whfyczcj	198	20	is	be	VBZ
cord-260476-whfyczcj	198	21	important	important	JJ
cord-260476-whfyczcj	198	22	in	in	IN
cord-260476-whfyczcj	198	23	this	this	DT
cord-260476-whfyczcj	198	24	mechanism	mechanism	NN
cord-260476-whfyczcj	198	25	[	[	-LRB-
cord-260476-whfyczcj	198	26	123	123	CD
cord-260476-whfyczcj	198	27	,	,	,
cord-260476-whfyczcj	198	28	124	124	CD
cord-260476-whfyczcj	198	29	]	]	-RRB-
cord-260476-whfyczcj	198	30	.	.	.
cord-260476-whfyczcj	199	1	Degradation	degradation	NN
cord-260476-whfyczcj	199	2	of	of	IN
cord-260476-whfyczcj	199	3	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	199	4	leads	lead	VBZ
cord-260476-whfyczcj	199	5	to	to	IN
cord-260476-whfyczcj	199	6	an	an	DT
cord-260476-whfyczcj	199	7	increase	increase	NN
cord-260476-whfyczcj	199	8	in	in	IN
cord-260476-whfyczcj	199	9	cellular	cellular	JJ
cord-260476-whfyczcj	199	10	dNTP	dNTP	NNS
cord-260476-whfyczcj	199	11	levels	level	NNS
cord-260476-whfyczcj	199	12	and	and	CC
cord-260476-whfyczcj	199	13	the	the	DT
cord-260476-whfyczcj	199	14	efficiency	efficiency	NN
cord-260476-whfyczcj	199	15	of	of	IN
cord-260476-whfyczcj	199	16	proviral	proviral	JJ
cord-260476-whfyczcj	199	17	DNA	dna	NN
cord-260476-whfyczcj	199	18	synthesis	synthesis	NN
cord-260476-whfyczcj	199	19	[	[	-LRB-
cord-260476-whfyczcj	199	20	120	120	CD
cord-260476-whfyczcj	199	21	]	]	-RRB-
cord-260476-whfyczcj	199	22	.	.	.
cord-260476-whfyczcj	200	1	In	in	IN
cord-260476-whfyczcj	200	2	this	this	DT
cord-260476-whfyczcj	200	3	manner	manner	NN
cord-260476-whfyczcj	200	4	,	,	,
cord-260476-whfyczcj	200	5	the	the	DT
cord-260476-whfyczcj	200	6	Vpx	Vpx	NNP
cord-260476-whfyczcj	200	7	protein	protein	NN
cord-260476-whfyczcj	200	8	allows	allow	VBZ
cord-260476-whfyczcj	200	9	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	200	10	to	to	TO
cord-260476-whfyczcj	200	11	efficiently	efficiently	RB
cord-260476-whfyczcj	200	12	infect	infect	VB
cord-260476-whfyczcj	200	13	human	human	JJ
cord-260476-whfyczcj	200	14	dendritic	dendritic	JJ
cord-260476-whfyczcj	200	15	and	and	CC
cord-260476-whfyczcj	200	16	myeloid	myeloid	NN
cord-260476-whfyczcj	200	17	cells	cell	NNS
cord-260476-whfyczcj	200	18	and	and	CC
cord-260476-whfyczcj	200	19	it	-PRON-	PRP
cord-260476-whfyczcj	200	20	significantly	significantly	RB
cord-260476-whfyczcj	200	21	increases	increase	VBZ
cord-260476-whfyczcj	200	22	the	the	DT
cord-260476-whfyczcj	200	23	infection	infection	NN
cord-260476-whfyczcj	200	24	by	by	IN
cord-260476-whfyczcj	200	25	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	200	26	[	[	-LRB-
cord-260476-whfyczcj	200	27	83	83	CD
cord-260476-whfyczcj	200	28	]	]	-RRB-
cord-260476-whfyczcj	200	29	.	.	.
cord-260476-whfyczcj	201	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	201	2	therefore	therefore	RB
cord-260476-whfyczcj	201	3	seems	seem	VBZ
cord-260476-whfyczcj	201	4	to	to	TO
cord-260476-whfyczcj	201	5	be	be	VB
cord-260476-whfyczcj	201	6	an	an	DT
cord-260476-whfyczcj	201	7	important	important	JJ
cord-260476-whfyczcj	201	8	protein	protein	NN
cord-260476-whfyczcj	201	9	for	for	IN
cord-260476-whfyczcj	201	10	viral	viral	JJ
cord-260476-whfyczcj	201	11	replication	replication	NN
cord-260476-whfyczcj	201	12	,	,	,
cord-260476-whfyczcj	201	13	however	however	RB
cord-260476-whfyczcj	201	14	it	-PRON-	PRP
cord-260476-whfyczcj	201	15	is	be	VBZ
cord-260476-whfyczcj	201	16	present	present	JJ
cord-260476-whfyczcj	201	17	exclusively	exclusively	RB
cord-260476-whfyczcj	201	18	in	in	IN
cord-260476-whfyczcj	201	19	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	201	20	and	and	CC
cord-260476-whfyczcj	201	21	some	some	DT
cord-260476-whfyczcj	201	22	SIV	SIV	NNP
cord-260476-whfyczcj	201	23	strains	strain	NNS
cord-260476-whfyczcj	201	24	.	.	.
cord-260476-whfyczcj	202	1	In	in	IN
cord-260476-whfyczcj	202	2	these	these	DT
cord-260476-whfyczcj	202	3	lineages	lineage	NNS
cord-260476-whfyczcj	202	4	,	,	,
cord-260476-whfyczcj	202	5	the	the	DT
cord-260476-whfyczcj	202	6	Vpx	Vpx	NNP
cord-260476-whfyczcj	202	7	gene	gene	NN
cord-260476-whfyczcj	202	8	has	have	VBZ
cord-260476-whfyczcj	202	9	evolved	evolve	VBN
cord-260476-whfyczcj	202	10	from	from	IN
cord-260476-whfyczcj	202	11	Vpr	Vpr	NNP
cord-260476-whfyczcj	202	12	which	which	WDT
cord-260476-whfyczcj	202	13	is	be	VBZ
cord-260476-whfyczcj	202	14	present	present	JJ
cord-260476-whfyczcj	202	15	in	in	IN
cord-260476-whfyczcj	202	16	all	all	DT
cord-260476-whfyczcj	202	17	HIV	HIV	NNP
cord-260476-whfyczcj	202	18	and	and	CC
cord-260476-whfyczcj	202	19	SIV	SIV	NNP
cord-260476-whfyczcj	202	20	strains	strain	NNS
cord-260476-whfyczcj	202	21	and	and	CC
cord-260476-whfyczcj	202	22	whose	whose	WP$
cord-260476-whfyczcj	202	23	main	main	JJ
cord-260476-whfyczcj	202	24	function	function	NN
cord-260476-whfyczcj	202	25	is	be	VBZ
cord-260476-whfyczcj	202	26	the	the	DT
cord-260476-whfyczcj	202	27	induction	induction	NN
cord-260476-whfyczcj	202	28	of	of	IN
cord-260476-whfyczcj	202	29	cell	cell	NN
cord-260476-whfyczcj	202	30	cycle	cycle	NN
cord-260476-whfyczcj	202	31	arrest	arrest	NN
cord-260476-whfyczcj	202	32	[	[	-LRB-
cord-260476-whfyczcj	202	33	125	125	CD
cord-260476-whfyczcj	202	34	]	]	-RRB-
cord-260476-whfyczcj	202	35	[	[	-LRB-
cord-260476-whfyczcj	202	36	126	126	CD
cord-260476-whfyczcj	202	37	]	]	-RRB-
cord-260476-whfyczcj	202	38	[	[	-LRB-
cord-260476-whfyczcj	202	39	127	127	CD
cord-260476-whfyczcj	202	40	]	]	-RRB-
cord-260476-whfyczcj	202	41	[	[	-LRB-
cord-260476-whfyczcj	202	42	128	128	CD
cord-260476-whfyczcj	202	43	]	]	-RRB-
cord-260476-whfyczcj	202	44	[	[	-LRB-
cord-260476-whfyczcj	202	45	129	129	CD
cord-260476-whfyczcj	202	46	]	]	-RRB-
cord-260476-whfyczcj	202	47	.	.	.
cord-260476-whfyczcj	203	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	203	2	and	and	CC
cord-260476-whfyczcj	203	3	Vpr	Vpr	NNP
cord-260476-whfyczcj	203	4	share	share	VBP
cord-260476-whfyczcj	203	5	many	many	JJ
cord-260476-whfyczcj	203	6	similarities	similarity	NNS
cord-260476-whfyczcj	203	7	,	,	,
cord-260476-whfyczcj	203	8	like	like	IN
cord-260476-whfyczcj	203	9	for	for	IN
cord-260476-whfyczcj	203	10	example	example	NN
cord-260476-whfyczcj	203	11	their	-PRON-	PRP$
cord-260476-whfyczcj	203	12	interaction	interaction	NN
cord-260476-whfyczcj	203	13	with	with	IN
cord-260476-whfyczcj	203	14	the	the	DT
cord-260476-whfyczcj	203	15	same	same	JJ
cord-260476-whfyczcj	203	16	CUL4A	cul4a	NN
cord-260476-whfyczcj	203	17	E3	e3	NN
cord-260476-whfyczcj	203	18	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	203	19	ligase	ligase	NN
cord-260476-whfyczcj	203	20	[	[	-LRB-
cord-260476-whfyczcj	203	21	122	122	CD
cord-260476-whfyczcj	203	22	,	,	,
cord-260476-whfyczcj	203	23	125	125	CD
cord-260476-whfyczcj	203	24	]	]	-RRB-
cord-260476-whfyczcj	203	25	.	.	.
cord-260476-whfyczcj	204	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	204	2	,	,	,
cord-260476-whfyczcj	204	3	the	the	DT
cord-260476-whfyczcj	204	4	Vpr	Vpr	NNP
cord-260476-whfyczcj	204	5	protein	protein	NN
cord-260476-whfyczcj	204	6	of	of	IN
cord-260476-whfyczcj	204	7	some	some	DT
cord-260476-whfyczcj	204	8	SIV	SIV	NNP
cord-260476-whfyczcj	204	9	strains	strain	NNS
cord-260476-whfyczcj	204	10	has	have	VBZ
cord-260476-whfyczcj	204	11	been	be	VBN
cord-260476-whfyczcj	204	12	shown	show	VBN
cord-260476-whfyczcj	204	13	to	to	TO
cord-260476-whfyczcj	204	14	induce	induce	VB
cord-260476-whfyczcj	204	15	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	204	16	degradation	degradation	NN
cord-260476-whfyczcj	204	17	of	of	IN
cord-260476-whfyczcj	204	18	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	204	19	,	,	,
cord-260476-whfyczcj	204	20	thereby	thereby	RB
cord-260476-whfyczcj	204	21	compensating	compensate	VBG
cord-260476-whfyczcj	204	22	for	for	IN
cord-260476-whfyczcj	204	23	the	the	DT
cord-260476-whfyczcj	204	24	lack	lack	NN
cord-260476-whfyczcj	204	25	of	of	IN
cord-260476-whfyczcj	204	26	Vpx	Vpx	NNP
cord-260476-whfyczcj	204	27	.	.	.
cord-260476-whfyczcj	205	1	Indeed	indeed	RB
cord-260476-whfyczcj	205	2	it	-PRON-	PRP
cord-260476-whfyczcj	205	3	seems	seem	VBZ
cord-260476-whfyczcj	205	4	that	that	IN
cord-260476-whfyczcj	205	5	the	the	DT
cord-260476-whfyczcj	205	6	ability	ability	NN
cord-260476-whfyczcj	205	7	to	to	TO
cord-260476-whfyczcj	205	8	degrade	degrade	VB
cord-260476-whfyczcj	205	9	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	205	10	has	have	VBZ
cord-260476-whfyczcj	205	11	first	first	RB
cord-260476-whfyczcj	205	12	been	be	VBN
cord-260476-whfyczcj	205	13	acquired	acquire	VBN
cord-260476-whfyczcj	205	14	by	by	IN
cord-260476-whfyczcj	205	15	the	the	DT
cord-260476-whfyczcj	205	16	Vpr	Vpr	NNP
cord-260476-whfyczcj	205	17	protein	protein	NN
cord-260476-whfyczcj	205	18	in	in	IN
cord-260476-whfyczcj	205	19	certain	certain	JJ
cord-260476-whfyczcj	205	20	lentiviral	lentiviral	JJ
cord-260476-whfyczcj	205	21	strains	strain	NNS
cord-260476-whfyczcj	205	22	before	before	IN
cord-260476-whfyczcj	205	23	the	the	DT
cord-260476-whfyczcj	205	24	evolution	evolution	NN
cord-260476-whfyczcj	205	25	of	of	IN
cord-260476-whfyczcj	205	26	a	a	DT
cord-260476-whfyczcj	205	27	separate	separate	JJ
cord-260476-whfyczcj	205	28	Vpx	Vpx	NNP
cord-260476-whfyczcj	205	29	gene	gene	NN
cord-260476-whfyczcj	205	30	which	which	WDT
cord-260476-whfyczcj	205	31	has	have	VBZ
cord-260476-whfyczcj	205	32	subsequently	subsequently	RB
cord-260476-whfyczcj	205	33	conserved	conserve	VBN
cord-260476-whfyczcj	205	34	the	the	DT
cord-260476-whfyczcj	205	35	function	function	NN
cord-260476-whfyczcj	205	36	of	of	IN
cord-260476-whfyczcj	205	37	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	205	38	antagonism	antagonism	NN
cord-260476-whfyczcj	205	39	[	[	-LRB-
cord-260476-whfyczcj	205	40	84	84	CD
cord-260476-whfyczcj	205	41	,	,	,
cord-260476-whfyczcj	205	42	130	130	CD
cord-260476-whfyczcj	205	43	]	]	-RRB-
cord-260476-whfyczcj	205	44	.	.	.
cord-260476-whfyczcj	206	1	Nevertheless	nevertheless	RB
cord-260476-whfyczcj	206	2	,	,	,
cord-260476-whfyczcj	206	3	many	many	JJ
cord-260476-whfyczcj	206	4	lineages	lineage	NNS
cord-260476-whfyczcj	206	5	,	,	,
cord-260476-whfyczcj	206	6	like	like	IN
cord-260476-whfyczcj	206	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	206	8	for	for	IN
cord-260476-whfyczcj	206	9	example	example	NN
cord-260476-whfyczcj	206	10	,	,	,
cord-260476-whfyczcj	206	11	lack	lack	VBP
cord-260476-whfyczcj	206	12	an	an	DT
cord-260476-whfyczcj	206	13	anti	anti	JJ
cord-260476-whfyczcj	206	14	-	-	JJ
cord-260476-whfyczcj	206	15	SAMHD1	samhd1	JJ
cord-260476-whfyczcj	206	16	activity	activity	NN
cord-260476-whfyczcj	206	17	.	.	.
cord-260476-whfyczcj	207	1	HIV	HIV	NNP
cord-260476-whfyczcj	208	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	208	2	,	,	,
cord-260476-whfyczcj	208	3	SAMHD1	SAMHD1	VBZ
cord-260476-whfyczcj	208	4	seems	seem	VBZ
cord-260476-whfyczcj	208	5	to	to	TO
cord-260476-whfyczcj	208	6	be	be	VB
cord-260476-whfyczcj	208	7	regulated	regulate	VBN
cord-260476-whfyczcj	208	8	in	in	IN
cord-260476-whfyczcj	208	9	cells	cell	NNS
cord-260476-whfyczcj	208	10	by	by	IN
cord-260476-whfyczcj	208	11	phosphorylation	phosphorylation	NN
cord-260476-whfyczcj	208	12	mediated	mediate	VBN
cord-260476-whfyczcj	208	13	by	by	IN
cord-260476-whfyczcj	209	1	CDK6-(Cyclin	CDK6-(Cyclin	NNP
cord-260476-whfyczcj	209	2	-	-	HYPH
cord-260476-whfyczcj	209	3	Dependent	dependent	JJ
cord-260476-whfyczcj	209	4	Kinase	Kinase	NNP
cord-260476-whfyczcj	209	5	6	6	CD
cord-260476-whfyczcj	210	1	)	)	-RRB-
cord-260476-whfyczcj	210	2	dependent	dependent	JJ
cord-260476-whfyczcj	210	3	CDK2	CDK2	NNP
cord-260476-whfyczcj	210	4	,	,	,
cord-260476-whfyczcj	210	5	which	which	WDT
cord-260476-whfyczcj	210	6	links	link	VBZ
cord-260476-whfyczcj	210	7	its	-PRON-	PRP$
cord-260476-whfyczcj	210	8	activity	activity	NN
cord-260476-whfyczcj	210	9	to	to	IN
cord-260476-whfyczcj	210	10	cell	cell	NN
cord-260476-whfyczcj	210	11	cycle	cycle	NN
cord-260476-whfyczcj	210	12	control	control	NN
cord-260476-whfyczcj	210	13	.	.	.
cord-260476-whfyczcj	211	1	Indeed	indeed	RB
cord-260476-whfyczcj	211	2	,	,	,
cord-260476-whfyczcj	211	3	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	211	4	is	be	VBZ
cord-260476-whfyczcj	211	5	phosphorylated	phosphorylate	VBN
cord-260476-whfyczcj	211	6	in	in	IN
cord-260476-whfyczcj	211	7	cycling	cycling	NN
cord-260476-whfyczcj	211	8	cells	cell	NNS
cord-260476-whfyczcj	211	9	which	which	WDT
cord-260476-whfyczcj	211	10	blocks	block	VBZ
cord-260476-whfyczcj	211	11	its	-PRON-	PRP$
cord-260476-whfyczcj	211	12	activity	activity	NN
cord-260476-whfyczcj	211	13	as	as	IN
cord-260476-whfyczcj	211	14	a	a	DT
cord-260476-whfyczcj	211	15	dNTP	dNTP	NNP
cord-260476-whfyczcj	211	16	hydrolase	hydrolase	NN
cord-260476-whfyczcj	211	17	[	[	-LRB-
cord-260476-whfyczcj	211	18	131	131	CD
cord-260476-whfyczcj	211	19	]	]	-RRB-
cord-260476-whfyczcj	211	20	.	.	.
cord-260476-whfyczcj	212	1	This	this	DT
cord-260476-whfyczcj	212	2	correlates	correlate	VBZ
cord-260476-whfyczcj	212	3	with	with	IN
cord-260476-whfyczcj	212	4	the	the	DT
cord-260476-whfyczcj	212	5	permissiveness	permissiveness	NN
cord-260476-whfyczcj	212	6	of	of	IN
cord-260476-whfyczcj	212	7	cycling	cycling	NN
cord-260476-whfyczcj	212	8	cells	cell	NNS
cord-260476-whfyczcj	212	9	for	for	IN
cord-260476-whfyczcj	212	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	212	11	infection	infection	NN
cord-260476-whfyczcj	212	12	as	as	IN
cord-260476-whfyczcj	212	13	opposed	oppose	VBN
cord-260476-whfyczcj	212	14	to	to	IN
cord-260476-whfyczcj	212	15	non	non	JJ
cord-260476-whfyczcj	212	16	-	-	JJ
cord-260476-whfyczcj	212	17	cycling	cycling	JJ
cord-260476-whfyczcj	212	18	cells	cell	NNS
cord-260476-whfyczcj	212	19	.	.	.
cord-260476-whfyczcj	213	1	Moreover	moreover	RB
cord-260476-whfyczcj	213	2	,	,	,
cord-260476-whfyczcj	213	3	HIV	HIV	NNP
cord-260476-whfyczcj	213	4	infection	infection	NN
cord-260476-whfyczcj	213	5	is	be	VBZ
cord-260476-whfyczcj	213	6	made	make	VBN
cord-260476-whfyczcj	213	7	possible	possible	JJ
cord-260476-whfyczcj	213	8	despite	despite	IN
cord-260476-whfyczcj	213	9	the	the	DT
cord-260476-whfyczcj	213	10	lack	lack	NN
cord-260476-whfyczcj	213	11	of	of	IN
cord-260476-whfyczcj	213	12	a	a	DT
cord-260476-whfyczcj	213	13	viral	viral	JJ
cord-260476-whfyczcj	213	14	factor	factor	NN
cord-260476-whfyczcj	213	15	counteracting	counteract	VBG
cord-260476-whfyczcj	213	16	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	213	17	by	by	IN
cord-260476-whfyczcj	213	18	different	different	JJ
cord-260476-whfyczcj	213	19	cellular	cellular	JJ
cord-260476-whfyczcj	213	20	proteins	protein	NNS
cord-260476-whfyczcj	213	21	:	:	:
cord-260476-whfyczcj	213	22	CD81	CD81	NNP
cord-260476-whfyczcj	213	23	for	for	IN
cord-260476-whfyczcj	213	24	example	example	NN
cord-260476-whfyczcj	213	25	has	have	VBZ
cord-260476-whfyczcj	213	26	recently	recently	RB
cord-260476-whfyczcj	213	27	been	be	VBN
cord-260476-whfyczcj	213	28	shown	show	VBN
cord-260476-whfyczcj	213	29	to	to	TO
cord-260476-whfyczcj	213	30	favor	favor	VB
cord-260476-whfyczcj	213	31	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	213	32	infection	infection	NN
cord-260476-whfyczcj	213	33	by	by	IN
cord-260476-whfyczcj	213	34	interacting	interact	VBG
cord-260476-whfyczcj	213	35	with	with	IN
cord-260476-whfyczcj	213	36	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	213	37	and	and	CC
cord-260476-whfyczcj	213	38	stimulation	stimulation	NN
cord-260476-whfyczcj	213	39	of	of	IN
cord-260476-whfyczcj	213	40	its	-PRON-	PRP$
cord-260476-whfyczcj	213	41	proteasome	proteasome	NN
cord-260476-whfyczcj	213	42	-	-	HYPH
cord-260476-whfyczcj	213	43	dependent	dependent	JJ
cord-260476-whfyczcj	213	44	degradation	degradation	NN
cord-260476-whfyczcj	213	45	[	[	-LRB-
cord-260476-whfyczcj	213	46	132	132	CD
cord-260476-whfyczcj	213	47	]	]	-RRB-
cord-260476-whfyczcj	213	48	.	.	.
cord-260476-whfyczcj	214	1	Cyclin	Cyclin	NNP
cord-260476-whfyczcj	214	2	L2	L2	NNP
cord-260476-whfyczcj	214	3	also	also	RB
cord-260476-whfyczcj	214	4	induces	induce	VBZ
cord-260476-whfyczcj	214	5	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	214	6	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	214	7	degradation	degradation	NN
cord-260476-whfyczcj	214	8	through	through	IN
cord-260476-whfyczcj	214	9	interaction	interaction	NN
cord-260476-whfyczcj	214	10	with	with	IN
cord-260476-whfyczcj	214	11	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	215	1	and	and	CC
cord-260476-whfyczcj	215	2	DCAF1	DCAF1	NNP
cord-260476-whfyczcj	215	3	,	,	,
cord-260476-whfyczcj	215	4	a	a	DT
cord-260476-whfyczcj	215	5	mechanism	mechanism	NN
cord-260476-whfyczcj	215	6	interestingly	interestingly	RB
cord-260476-whfyczcj	215	7	similar	similar	JJ
cord-260476-whfyczcj	215	8	to	to	IN
cord-260476-whfyczcj	215	9	the	the	DT
cord-260476-whfyczcj	215	10	one	one	NN
cord-260476-whfyczcj	215	11	used	use	VBN
cord-260476-whfyczcj	215	12	by	by	IN
cord-260476-whfyczcj	215	13	Vpx	Vpx	NNP
cord-260476-whfyczcj	215	14	[	[	-LRB-
cord-260476-whfyczcj	215	15	133	133	CD
cord-260476-whfyczcj	215	16	]	]	-RRB-
cord-260476-whfyczcj	215	17	.	.	.
cord-260476-whfyczcj	216	1	affects	affect	VBZ
cord-260476-whfyczcj	216	2	infectivity	infectivity	NN
cord-260476-whfyczcj	216	3	of	of	IN
cord-260476-whfyczcj	216	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	216	5	in	in	IN
cord-260476-whfyczcj	216	6	these	these	DT
cord-260476-whfyczcj	216	7	cell	cell	NN
cord-260476-whfyczcj	216	8	types	type	NNS
cord-260476-whfyczcj	216	9	but	but	CC
cord-260476-whfyczcj	216	10	has	have	VBZ
cord-260476-whfyczcj	216	11	no	no	DT
cord-260476-whfyczcj	216	12	effect	effect	NN
cord-260476-whfyczcj	216	13	on	on	IN
cord-260476-whfyczcj	216	14	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	216	15	infectivity	infectivity	NN
cord-260476-whfyczcj	216	16	[	[	-LRB-
cord-260476-whfyczcj	216	17	121	121	CD
cord-260476-whfyczcj	216	18	]	]	-RRB-
cord-260476-whfyczcj	216	19	.	.	.
cord-260476-whfyczcj	217	1	Indeed	indeed	RB
cord-260476-whfyczcj	217	2	,	,	,
cord-260476-whfyczcj	217	3	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	217	4	possesses	possess	VBZ
cord-260476-whfyczcj	217	5	the	the	DT
cord-260476-whfyczcj	217	6	viral	viral	JJ
cord-260476-whfyczcj	217	7	protein	protein	NN
cord-260476-whfyczcj	217	8	X	x	NN
cord-260476-whfyczcj	217	9	(	(	-LRB-
cord-260476-whfyczcj	217	10	Vpx	Vpx	NNP
cord-260476-whfyczcj	217	11	,	,	,
cord-260476-whfyczcj	217	12	Figure	figure	NN
cord-260476-whfyczcj	217	13	5B	5b	NN
cord-260476-whfyczcj	217	14	)	)	-RRB-
cord-260476-whfyczcj	217	15	which	which	WDT
cord-260476-whfyczcj	217	16	alleviates	alleviate	VBZ
cord-260476-whfyczcj	217	17	the	the	DT
cord-260476-whfyczcj	217	18	post	post	JJ
cord-260476-whfyczcj	217	19	-	-	JJ
cord-260476-whfyczcj	217	20	entry	entry	JJ
cord-260476-whfyczcj	217	21	block	block	NN
cord-260476-whfyczcj	217	22	mediated	mediate	VBN
cord-260476-whfyczcj	217	23	by	by	IN
cord-260476-whfyczcj	217	24	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	217	25	by	by	IN
cord-260476-whfyczcj	217	26	inducing	induce	VBG
cord-260476-whfyczcj	217	27	its	-PRON-	PRP$
cord-260476-whfyczcj	217	28	degradation	degradation	NN
cord-260476-whfyczcj	217	29	by	by	IN
cord-260476-whfyczcj	217	30	the	the	DT
cord-260476-whfyczcj	217	31	proteasome	proteasome	NN
cord-260476-whfyczcj	217	32	.	.	.
cord-260476-whfyczcj	218	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	218	2	has	have	VBZ
cord-260476-whfyczcj	218	3	been	be	VBN
cord-260476-whfyczcj	218	4	found	find	VBN
cord-260476-whfyczcj	218	5	to	to	TO
cord-260476-whfyczcj	218	6	recruit	recruit	VB
cord-260476-whfyczcj	218	7	the	the	DT
cord-260476-whfyczcj	218	8	CUL4A	cul4a	NN
cord-260476-whfyczcj	218	9	-	-	HYPH
cord-260476-whfyczcj	218	10	DDB1-DCAF1(DDB1	DDB1-DCAF1(DDB1	NNP
cord-260476-whfyczcj	218	11	and	and	CC
cord-260476-whfyczcj	218	12	CUL4	CUL4	NNP
cord-260476-whfyczcj	218	13	Associated	Associated	NNP
cord-260476-whfyczcj	218	14	Factor	Factor	NNP
cord-260476-whfyczcj	218	15	1	1	CD
cord-260476-whfyczcj	218	16	)	)	-RRB-
cord-260476-whfyczcj	218	17	E3	e3	NN
cord-260476-whfyczcj	218	18	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	218	19	ligase	ligase	NN
cord-260476-whfyczcj	218	20	through	through	IN
cord-260476-whfyczcj	218	21	a	a	DT
cord-260476-whfyczcj	218	22	direct	direct	JJ
cord-260476-whfyczcj	218	23	interaction	interaction	NN
cord-260476-whfyczcj	218	24	with	with	IN
cord-260476-whfyczcj	218	25	its	-PRON-	PRP$
cord-260476-whfyczcj	218	26	substrate	substrate	NN
cord-260476-whfyczcj	218	27	recognition	recognition	NN
cord-260476-whfyczcj	218	28	protein	protein	NN
cord-260476-whfyczcj	218	29	DCAF1	DCAF1	NNP
cord-260476-whfyczcj	219	1	(	(	-LRB-
cord-260476-whfyczcj	219	2	DDB1	DDB1	NNP
cord-260476-whfyczcj	219	3	and	and	CC
cord-260476-whfyczcj	219	4	CUL4	CUL4	NNP
cord-260476-whfyczcj	219	5	Associated	Associated	NNP
cord-260476-whfyczcj	219	6	Factor	Factor	NNP
cord-260476-whfyczcj	219	7	1	1	CD
cord-260476-whfyczcj	219	8	)	)	-RRB-
cord-260476-whfyczcj	219	9	[	[	-LRB-
cord-260476-whfyczcj	219	10	122	122	CD
cord-260476-whfyczcj	219	11	]	]	-RRB-
cord-260476-whfyczcj	219	12	while	while	IN
cord-260476-whfyczcj	219	13	also	also	RB
cord-260476-whfyczcj	219	14	interacting	interact	VBG
cord-260476-whfyczcj	219	15	with	with	IN
cord-260476-whfyczcj	219	16	the	the	DT
cord-260476-whfyczcj	219	17	C	C	NNP
cord-260476-whfyczcj	219	18	-	-	HYPH
cord-260476-whfyczcj	219	19	terminal	terminal	NN
cord-260476-whfyczcj	219	20	domain	domain	NN
cord-260476-whfyczcj	219	21	of	of	IN
cord-260476-whfyczcj	219	22	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	219	23	,	,	,
cord-260476-whfyczcj	219	24	thereby	thereby	RB
cord-260476-whfyczcj	219	25	loading	load	VBG
cord-260476-whfyczcj	219	26	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	219	27	onto	onto	IN
cord-260476-whfyczcj	219	28	the	the	DT
cord-260476-whfyczcj	219	29	E3	E3	NNP
cord-260476-whfyczcj	219	30	complex	complex	NN
cord-260476-whfyczcj	219	31	and	and	CC
cord-260476-whfyczcj	219	32	inducing	induce	VBG
cord-260476-whfyczcj	219	33	its	-PRON-	PRP$
cord-260476-whfyczcj	219	34	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	219	35	followed	follow	VBN
cord-260476-whfyczcj	219	36	by	by	IN
cord-260476-whfyczcj	219	37	its	-PRON-	PRP$
cord-260476-whfyczcj	219	38	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	219	39	degradation	degradation	NN
cord-260476-whfyczcj	219	40	(	(	-LRB-
cord-260476-whfyczcj	219	41	Figure	figure	NN
cord-260476-whfyczcj	219	42	5C	5c	CD
cord-260476-whfyczcj	219	43	)	)	-RRB-
cord-260476-whfyczcj	219	44	.	.	.
cord-260476-whfyczcj	220	1	The	the	DT
cord-260476-whfyczcj	220	2	nuclear	nuclear	JJ
cord-260476-whfyczcj	220	3	localization	localization	NN
cord-260476-whfyczcj	220	4	of	of	IN
cord-260476-whfyczcj	220	5	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	220	6	is	be	VBZ
cord-260476-whfyczcj	220	7	required	require	VBN
cord-260476-whfyczcj	220	8	for	for	IN
cord-260476-whfyczcj	220	9	its	-PRON-	PRP$
cord-260476-whfyczcj	220	10	Vpx	Vpx	NNP
cord-260476-whfyczcj	220	11	-	-	HYPH
cord-260476-whfyczcj	220	12	induced	induce	VBN
cord-260476-whfyczcj	220	13	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	220	14	degradation	degradation	NN
cord-260476-whfyczcj	220	15	,	,	,
cord-260476-whfyczcj	220	16	suggesting	suggest	VBG
cord-260476-whfyczcj	220	17	the	the	DT
cord-260476-whfyczcj	220	18	nuclear	nuclear	JJ
cord-260476-whfyczcj	220	19	UPS	UPS	NNP
cord-260476-whfyczcj	220	20	is	be	VBZ
cord-260476-whfyczcj	220	21	important	important	JJ
cord-260476-whfyczcj	220	22	in	in	IN
cord-260476-whfyczcj	220	23	this	this	DT
cord-260476-whfyczcj	220	24	mechanism	mechanism	NN
cord-260476-whfyczcj	220	25	[	[	-LRB-
cord-260476-whfyczcj	220	26	123	123	CD
cord-260476-whfyczcj	220	27	,	,	,
cord-260476-whfyczcj	220	28	124	124	CD
cord-260476-whfyczcj	220	29	]	]	-RRB-
cord-260476-whfyczcj	220	30	.	.	.
cord-260476-whfyczcj	221	1	Degradation	degradation	NN
cord-260476-whfyczcj	221	2	of	of	IN
cord-260476-whfyczcj	221	3	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	221	4	leads	lead	VBZ
cord-260476-whfyczcj	221	5	to	to	IN
cord-260476-whfyczcj	221	6	an	an	DT
cord-260476-whfyczcj	221	7	increase	increase	NN
cord-260476-whfyczcj	221	8	in	in	IN
cord-260476-whfyczcj	221	9	cellular	cellular	JJ
cord-260476-whfyczcj	221	10	dNTP	dNTP	NNS
cord-260476-whfyczcj	221	11	levels	level	NNS
cord-260476-whfyczcj	221	12	and	and	CC
cord-260476-whfyczcj	221	13	the	the	DT
cord-260476-whfyczcj	221	14	efficiency	efficiency	NN
cord-260476-whfyczcj	221	15	of	of	IN
cord-260476-whfyczcj	221	16	proviral	proviral	JJ
cord-260476-whfyczcj	221	17	DNA	dna	NN
cord-260476-whfyczcj	221	18	synthesis	synthesis	NN
cord-260476-whfyczcj	221	19	[	[	-LRB-
cord-260476-whfyczcj	221	20	120	120	CD
cord-260476-whfyczcj	221	21	]	]	-RRB-
cord-260476-whfyczcj	221	22	.	.	.
cord-260476-whfyczcj	222	1	In	in	IN
cord-260476-whfyczcj	222	2	this	this	DT
cord-260476-whfyczcj	222	3	manner	manner	NN
cord-260476-whfyczcj	222	4	,	,	,
cord-260476-whfyczcj	222	5	the	the	DT
cord-260476-whfyczcj	222	6	Vpx	Vpx	NNP
cord-260476-whfyczcj	222	7	protein	protein	NN
cord-260476-whfyczcj	222	8	allows	allow	VBZ
cord-260476-whfyczcj	222	9	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	222	10	to	to	TO
cord-260476-whfyczcj	222	11	efficiently	efficiently	RB
cord-260476-whfyczcj	222	12	infect	infect	VB
cord-260476-whfyczcj	222	13	human	human	JJ
cord-260476-whfyczcj	222	14	dendritic	dendritic	JJ
cord-260476-whfyczcj	222	15	and	and	CC
cord-260476-whfyczcj	222	16	myeloid	myeloid	NN
cord-260476-whfyczcj	222	17	cells	cell	NNS
cord-260476-whfyczcj	222	18	and	and	CC
cord-260476-whfyczcj	222	19	it	-PRON-	PRP
cord-260476-whfyczcj	222	20	significantly	significantly	RB
cord-260476-whfyczcj	222	21	increases	increase	VBZ
cord-260476-whfyczcj	222	22	the	the	DT
cord-260476-whfyczcj	222	23	infection	infection	NN
cord-260476-whfyczcj	222	24	by	by	IN
cord-260476-whfyczcj	222	25	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	222	26	[	[	-LRB-
cord-260476-whfyczcj	222	27	83	83	CD
cord-260476-whfyczcj	222	28	]	]	-RRB-
cord-260476-whfyczcj	222	29	.	.	.
cord-260476-whfyczcj	223	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	223	2	therefore	therefore	RB
cord-260476-whfyczcj	223	3	seems	seem	VBZ
cord-260476-whfyczcj	223	4	to	to	TO
cord-260476-whfyczcj	223	5	be	be	VB
cord-260476-whfyczcj	223	6	an	an	DT
cord-260476-whfyczcj	223	7	important	important	JJ
cord-260476-whfyczcj	223	8	protein	protein	NN
cord-260476-whfyczcj	223	9	for	for	IN
cord-260476-whfyczcj	223	10	viral	viral	JJ
cord-260476-whfyczcj	223	11	replication	replication	NN
cord-260476-whfyczcj	223	12	,	,	,
cord-260476-whfyczcj	223	13	however	however	RB
cord-260476-whfyczcj	223	14	it	-PRON-	PRP
cord-260476-whfyczcj	223	15	is	be	VBZ
cord-260476-whfyczcj	223	16	present	present	JJ
cord-260476-whfyczcj	223	17	exclusively	exclusively	RB
cord-260476-whfyczcj	223	18	in	in	IN
cord-260476-whfyczcj	223	19	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	223	20	and	and	CC
cord-260476-whfyczcj	223	21	some	some	DT
cord-260476-whfyczcj	223	22	SIV	SIV	NNP
cord-260476-whfyczcj	223	23	strains	strain	NNS
cord-260476-whfyczcj	223	24	.	.	.
cord-260476-whfyczcj	224	1	In	in	IN
cord-260476-whfyczcj	224	2	these	these	DT
cord-260476-whfyczcj	224	3	lineages	lineage	NNS
cord-260476-whfyczcj	224	4	,	,	,
cord-260476-whfyczcj	224	5	the	the	DT
cord-260476-whfyczcj	224	6	Vpx	Vpx	NNP
cord-260476-whfyczcj	224	7	gene	gene	NN
cord-260476-whfyczcj	224	8	has	have	VBZ
cord-260476-whfyczcj	224	9	evolved	evolve	VBN
cord-260476-whfyczcj	224	10	from	from	IN
cord-260476-whfyczcj	224	11	Vpr	Vpr	NNP
cord-260476-whfyczcj	224	12	which	which	WDT
cord-260476-whfyczcj	224	13	is	be	VBZ
cord-260476-whfyczcj	224	14	present	present	JJ
cord-260476-whfyczcj	224	15	in	in	IN
cord-260476-whfyczcj	224	16	all	all	DT
cord-260476-whfyczcj	224	17	HIV	HIV	NNP
cord-260476-whfyczcj	224	18	and	and	CC
cord-260476-whfyczcj	224	19	SIV	SIV	NNP
cord-260476-whfyczcj	224	20	strains	strain	NNS
cord-260476-whfyczcj	224	21	and	and	CC
cord-260476-whfyczcj	224	22	whose	whose	WP$
cord-260476-whfyczcj	224	23	main	main	JJ
cord-260476-whfyczcj	224	24	function	function	NN
cord-260476-whfyczcj	224	25	is	be	VBZ
cord-260476-whfyczcj	224	26	the	the	DT
cord-260476-whfyczcj	224	27	induction	induction	NN
cord-260476-whfyczcj	224	28	of	of	IN
cord-260476-whfyczcj	224	29	cell	cell	NN
cord-260476-whfyczcj	224	30	cycle	cycle	NN
cord-260476-whfyczcj	224	31	arrest	arrest	NN
cord-260476-whfyczcj	224	32	[	[	-LRB-
cord-260476-whfyczcj	224	33	125	125	CD
cord-260476-whfyczcj	224	34	]	]	-RRB-
cord-260476-whfyczcj	224	35	[	[	-LRB-
cord-260476-whfyczcj	224	36	126	126	CD
cord-260476-whfyczcj	224	37	]	]	-RRB-
cord-260476-whfyczcj	224	38	[	[	-LRB-
cord-260476-whfyczcj	224	39	127	127	CD
cord-260476-whfyczcj	224	40	]	]	-RRB-
cord-260476-whfyczcj	224	41	[	[	-LRB-
cord-260476-whfyczcj	224	42	128	128	CD
cord-260476-whfyczcj	224	43	]	]	-RRB-
cord-260476-whfyczcj	224	44	[	[	-LRB-
cord-260476-whfyczcj	224	45	129	129	CD
cord-260476-whfyczcj	224	46	]	]	-RRB-
cord-260476-whfyczcj	224	47	.	.	.
cord-260476-whfyczcj	225	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	225	2	and	and	CC
cord-260476-whfyczcj	225	3	Vpr	Vpr	NNP
cord-260476-whfyczcj	225	4	share	share	VBP
cord-260476-whfyczcj	225	5	many	many	JJ
cord-260476-whfyczcj	225	6	similarities	similarity	NNS
cord-260476-whfyczcj	225	7	,	,	,
cord-260476-whfyczcj	225	8	like	like	IN
cord-260476-whfyczcj	225	9	for	for	IN
cord-260476-whfyczcj	225	10	example	example	NN
cord-260476-whfyczcj	225	11	their	-PRON-	PRP$
cord-260476-whfyczcj	225	12	interaction	interaction	NN
cord-260476-whfyczcj	225	13	with	with	IN
cord-260476-whfyczcj	225	14	the	the	DT
cord-260476-whfyczcj	225	15	same	same	JJ
cord-260476-whfyczcj	225	16	CUL4A	cul4a	NN
cord-260476-whfyczcj	225	17	E3	e3	NN
cord-260476-whfyczcj	225	18	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	225	19	ligase	ligase	NN
cord-260476-whfyczcj	225	20	[	[	-LRB-
cord-260476-whfyczcj	225	21	122	122	CD
cord-260476-whfyczcj	225	22	,	,	,
cord-260476-whfyczcj	225	23	125	125	CD
cord-260476-whfyczcj	225	24	]	]	-RRB-
cord-260476-whfyczcj	225	25	.	.	.
cord-260476-whfyczcj	226	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	226	2	,	,	,
cord-260476-whfyczcj	226	3	the	the	DT
cord-260476-whfyczcj	226	4	Vpr	Vpr	NNP
cord-260476-whfyczcj	226	5	protein	protein	NN
cord-260476-whfyczcj	226	6	of	of	IN
cord-260476-whfyczcj	226	7	some	some	DT
cord-260476-whfyczcj	226	8	SIV	SIV	NNP
cord-260476-whfyczcj	226	9	strains	strain	NNS
cord-260476-whfyczcj	226	10	has	have	VBZ
cord-260476-whfyczcj	226	11	been	be	VBN
cord-260476-whfyczcj	226	12	shown	show	VBN
cord-260476-whfyczcj	226	13	to	to	TO
cord-260476-whfyczcj	226	14	induce	induce	VB
cord-260476-whfyczcj	226	15	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	226	16	degradation	degradation	NN
cord-260476-whfyczcj	226	17	of	of	IN
cord-260476-whfyczcj	226	18	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	226	19	,	,	,
cord-260476-whfyczcj	226	20	thereby	thereby	RB
cord-260476-whfyczcj	226	21	compensating	compensate	VBG
cord-260476-whfyczcj	226	22	for	for	IN
cord-260476-whfyczcj	226	23	the	the	DT
cord-260476-whfyczcj	226	24	lack	lack	NN
cord-260476-whfyczcj	226	25	of	of	IN
cord-260476-whfyczcj	226	26	Vpx	Vpx	NNP
cord-260476-whfyczcj	226	27	.	.	.
cord-260476-whfyczcj	227	1	Indeed	indeed	RB
cord-260476-whfyczcj	227	2	it	-PRON-	PRP
cord-260476-whfyczcj	227	3	seems	seem	VBZ
cord-260476-whfyczcj	227	4	that	that	IN
cord-260476-whfyczcj	227	5	the	the	DT
cord-260476-whfyczcj	227	6	ability	ability	NN
cord-260476-whfyczcj	227	7	to	to	TO
cord-260476-whfyczcj	227	8	degrade	degrade	VB
cord-260476-whfyczcj	227	9	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	227	10	has	have	VBZ
cord-260476-whfyczcj	227	11	first	first	RB
cord-260476-whfyczcj	227	12	been	be	VBN
cord-260476-whfyczcj	227	13	acquired	acquire	VBN
cord-260476-whfyczcj	227	14	by	by	IN
cord-260476-whfyczcj	227	15	the	the	DT
cord-260476-whfyczcj	227	16	Vpr	Vpr	NNP
cord-260476-whfyczcj	227	17	protein	protein	NN
cord-260476-whfyczcj	227	18	in	in	IN
cord-260476-whfyczcj	227	19	certain	certain	JJ
cord-260476-whfyczcj	227	20	lentiviral	lentiviral	JJ
cord-260476-whfyczcj	227	21	strains	strain	NNS
cord-260476-whfyczcj	227	22	before	before	IN
cord-260476-whfyczcj	227	23	the	the	DT
cord-260476-whfyczcj	227	24	evolution	evolution	NN
cord-260476-whfyczcj	227	25	of	of	IN
cord-260476-whfyczcj	227	26	a	a	DT
cord-260476-whfyczcj	227	27	separate	separate	JJ
cord-260476-whfyczcj	227	28	Vpx	Vpx	NNP
cord-260476-whfyczcj	227	29	gene	gene	NN
cord-260476-whfyczcj	227	30	which	which	WDT
cord-260476-whfyczcj	227	31	has	have	VBZ
cord-260476-whfyczcj	227	32	subsequently	subsequently	RB
cord-260476-whfyczcj	227	33	conserved	conserve	VBN
cord-260476-whfyczcj	227	34	the	the	DT
cord-260476-whfyczcj	227	35	function	function	NN
cord-260476-whfyczcj	227	36	of	of	IN
cord-260476-whfyczcj	227	37	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	227	38	antagonism	antagonism	NN
cord-260476-whfyczcj	227	39	[	[	-LRB-
cord-260476-whfyczcj	227	40	84	84	CD
cord-260476-whfyczcj	227	41	,	,	,
cord-260476-whfyczcj	227	42	130	130	CD
cord-260476-whfyczcj	227	43	]	]	-RRB-
cord-260476-whfyczcj	227	44	.	.	.
cord-260476-whfyczcj	228	1	Nevertheless	nevertheless	RB
cord-260476-whfyczcj	228	2	,	,	,
cord-260476-whfyczcj	228	3	many	many	JJ
cord-260476-whfyczcj	228	4	lineages	lineage	NNS
cord-260476-whfyczcj	228	5	,	,	,
cord-260476-whfyczcj	228	6	like	like	IN
cord-260476-whfyczcj	228	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	228	8	for	for	IN
cord-260476-whfyczcj	228	9	example	example	NN
cord-260476-whfyczcj	228	10	,	,	,
cord-260476-whfyczcj	228	11	lack	lack	VBP
cord-260476-whfyczcj	228	12	an	an	DT
cord-260476-whfyczcj	228	13	anti	anti	JJ
cord-260476-whfyczcj	228	14	-	-	JJ
cord-260476-whfyczcj	228	15	SAMHD1	samhd1	JJ
cord-260476-whfyczcj	228	16	activity	activity	NN
cord-260476-whfyczcj	228	17	.	.	.
cord-260476-whfyczcj	229	1	HIV	HIV	NNP
cord-260476-whfyczcj	230	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	230	2	,	,	,
cord-260476-whfyczcj	230	3	SAMHD1	SAMHD1	VBZ
cord-260476-whfyczcj	230	4	seems	seem	VBZ
cord-260476-whfyczcj	230	5	to	to	TO
cord-260476-whfyczcj	230	6	be	be	VB
cord-260476-whfyczcj	230	7	regulated	regulate	VBN
cord-260476-whfyczcj	230	8	in	in	IN
cord-260476-whfyczcj	230	9	cells	cell	NNS
cord-260476-whfyczcj	230	10	by	by	IN
cord-260476-whfyczcj	230	11	phosphorylation	phosphorylation	NN
cord-260476-whfyczcj	230	12	mediated	mediate	VBN
cord-260476-whfyczcj	230	13	by	by	IN
cord-260476-whfyczcj	231	1	CDK6-(Cyclin	CDK6-(Cyclin	NNP
cord-260476-whfyczcj	231	2	-	-	HYPH
cord-260476-whfyczcj	231	3	Dependent	dependent	JJ
cord-260476-whfyczcj	231	4	Kinase	Kinase	NNP
cord-260476-whfyczcj	231	5	6	6	CD
cord-260476-whfyczcj	232	1	)	)	-RRB-
cord-260476-whfyczcj	232	2	dependent	dependent	JJ
cord-260476-whfyczcj	232	3	CDK2	CDK2	NNP
cord-260476-whfyczcj	232	4	,	,	,
cord-260476-whfyczcj	232	5	which	which	WDT
cord-260476-whfyczcj	232	6	links	link	VBZ
cord-260476-whfyczcj	232	7	its	-PRON-	PRP$
cord-260476-whfyczcj	232	8	activity	activity	NN
cord-260476-whfyczcj	232	9	to	to	IN
cord-260476-whfyczcj	232	10	cell	cell	NN
cord-260476-whfyczcj	232	11	cycle	cycle	NN
cord-260476-whfyczcj	232	12	control	control	NN
cord-260476-whfyczcj	232	13	.	.	.
cord-260476-whfyczcj	233	1	Indeed	indeed	RB
cord-260476-whfyczcj	233	2	,	,	,
cord-260476-whfyczcj	233	3	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	233	4	is	be	VBZ
cord-260476-whfyczcj	233	5	phosphorylated	phosphorylate	VBN
cord-260476-whfyczcj	233	6	in	in	IN
cord-260476-whfyczcj	233	7	cycling	cycling	NN
cord-260476-whfyczcj	233	8	cells	cell	NNS
cord-260476-whfyczcj	233	9	which	which	WDT
cord-260476-whfyczcj	233	10	blocks	block	VBZ
cord-260476-whfyczcj	233	11	its	-PRON-	PRP$
cord-260476-whfyczcj	233	12	activity	activity	NN
cord-260476-whfyczcj	233	13	as	as	IN
cord-260476-whfyczcj	233	14	a	a	DT
cord-260476-whfyczcj	233	15	dNTP	dNTP	NNP
cord-260476-whfyczcj	233	16	hydrolase	hydrolase	NN
cord-260476-whfyczcj	233	17	[	[	-LRB-
cord-260476-whfyczcj	233	18	131	131	CD
cord-260476-whfyczcj	233	19	]	]	-RRB-
cord-260476-whfyczcj	233	20	.	.	.
cord-260476-whfyczcj	234	1	This	this	DT
cord-260476-whfyczcj	234	2	correlates	correlate	VBZ
cord-260476-whfyczcj	234	3	with	with	IN
cord-260476-whfyczcj	234	4	the	the	DT
cord-260476-whfyczcj	234	5	permissiveness	permissiveness	NN
cord-260476-whfyczcj	234	6	of	of	IN
cord-260476-whfyczcj	234	7	cycling	cycling	NN
cord-260476-whfyczcj	234	8	cells	cell	NNS
cord-260476-whfyczcj	234	9	for	for	IN
cord-260476-whfyczcj	234	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	234	11	infection	infection	NN
cord-260476-whfyczcj	234	12	as	as	IN
cord-260476-whfyczcj	234	13	opposed	oppose	VBN
cord-260476-whfyczcj	234	14	to	to	IN
cord-260476-whfyczcj	234	15	non	non	JJ
cord-260476-whfyczcj	234	16	-	-	JJ
cord-260476-whfyczcj	234	17	cycling	cycling	JJ
cord-260476-whfyczcj	234	18	cells	cell	NNS
cord-260476-whfyczcj	234	19	.	.	.
cord-260476-whfyczcj	235	1	Moreover	moreover	RB
cord-260476-whfyczcj	235	2	,	,	,
cord-260476-whfyczcj	235	3	HIV	HIV	NNP
cord-260476-whfyczcj	235	4	infection	infection	NN
cord-260476-whfyczcj	235	5	is	be	VBZ
cord-260476-whfyczcj	235	6	made	make	VBN
cord-260476-whfyczcj	235	7	possible	possible	JJ
cord-260476-whfyczcj	235	8	despite	despite	IN
cord-260476-whfyczcj	235	9	the	the	DT
cord-260476-whfyczcj	235	10	lack	lack	NN
cord-260476-whfyczcj	235	11	of	of	IN
cord-260476-whfyczcj	235	12	a	a	DT
cord-260476-whfyczcj	235	13	viral	viral	JJ
cord-260476-whfyczcj	235	14	factor	factor	NN
cord-260476-whfyczcj	235	15	counteracting	counteract	VBG
cord-260476-whfyczcj	235	16	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	235	17	by	by	IN
cord-260476-whfyczcj	235	18	different	different	JJ
cord-260476-whfyczcj	235	19	cellular	cellular	JJ
cord-260476-whfyczcj	235	20	proteins	protein	NNS
cord-260476-whfyczcj	235	21	:	:	:
cord-260476-whfyczcj	235	22	CD81	CD81	NNP
cord-260476-whfyczcj	235	23	for	for	IN
cord-260476-whfyczcj	235	24	example	example	NN
cord-260476-whfyczcj	235	25	has	have	VBZ
cord-260476-whfyczcj	235	26	recently	recently	RB
cord-260476-whfyczcj	235	27	been	be	VBN
cord-260476-whfyczcj	235	28	shown	show	VBN
cord-260476-whfyczcj	235	29	to	to	TO
cord-260476-whfyczcj	235	30	favor	favor	VB
cord-260476-whfyczcj	235	31	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	235	32	infection	infection	NN
cord-260476-whfyczcj	235	33	by	by	IN
cord-260476-whfyczcj	235	34	interacting	interact	VBG
cord-260476-whfyczcj	235	35	with	with	IN
cord-260476-whfyczcj	235	36	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	235	37	and	and	CC
cord-260476-whfyczcj	235	38	stimulation	stimulation	NN
cord-260476-whfyczcj	235	39	of	of	IN
cord-260476-whfyczcj	235	40	its	-PRON-	PRP$
cord-260476-whfyczcj	235	41	proteasome	proteasome	NN
cord-260476-whfyczcj	235	42	-	-	HYPH
cord-260476-whfyczcj	235	43	dependent	dependent	JJ
cord-260476-whfyczcj	235	44	degradation	degradation	NN
cord-260476-whfyczcj	235	45	[	[	-LRB-
cord-260476-whfyczcj	235	46	132	132	CD
cord-260476-whfyczcj	235	47	]	]	-RRB-
cord-260476-whfyczcj	235	48	.	.	.
cord-260476-whfyczcj	236	1	Cyclin	Cyclin	NNP
cord-260476-whfyczcj	236	2	L2	L2	NNP
cord-260476-whfyczcj	236	3	also	also	RB
cord-260476-whfyczcj	236	4	induces	induce	VBZ
cord-260476-whfyczcj	236	5	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	236	6	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	236	7	degradation	degradation	NN
cord-260476-whfyczcj	236	8	through	through	IN
cord-260476-whfyczcj	236	9	interaction	interaction	NN
cord-260476-whfyczcj	236	10	with	with	IN
cord-260476-whfyczcj	236	11	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	237	1	and	and	CC
cord-260476-whfyczcj	237	2	DCAF1	DCAF1	NNP
cord-260476-whfyczcj	237	3	,	,	,
cord-260476-whfyczcj	237	4	a	a	DT
cord-260476-whfyczcj	237	5	mechanism	mechanism	NN
cord-260476-whfyczcj	237	6	interestingly	interestingly	RB
cord-260476-whfyczcj	237	7	similar	similar	JJ
cord-260476-whfyczcj	237	8	to	to	IN
cord-260476-whfyczcj	237	9	the	the	DT
cord-260476-whfyczcj	237	10	one	one	NN
cord-260476-whfyczcj	237	11	used	use	VBN
cord-260476-whfyczcj	237	12	by	by	IN
cord-260476-whfyczcj	237	13	Vpx	Vpx	NNP
cord-260476-whfyczcj	237	14	[	[	-LRB-
cord-260476-whfyczcj	237	15	133	133	CD
cord-260476-whfyczcj	237	16	]	]	-RRB-
cord-260476-whfyczcj	237	17	.	.	.
cord-260476-whfyczcj	237	18	 	 	_SP
cord-260476-whfyczcj	238	1	In	in	IN
cord-260476-whfyczcj	238	2	the	the	DT
cord-260476-whfyczcj	238	3	absence	absence	NN
cord-260476-whfyczcj	238	4	of	of	IN
cord-260476-whfyczcj	238	5	Vpu	Vpu	NNP
cord-260476-whfyczcj	238	6	,	,	,
cord-260476-whfyczcj	238	7	newly	newly	RB
cord-260476-whfyczcj	238	8	formed	form	VBN
cord-260476-whfyczcj	238	9	virions	virion	NNS
cord-260476-whfyczcj	238	10	remain	remain	VBP
cord-260476-whfyczcj	238	11	tethered	tethered	JJ
cord-260476-whfyczcj	238	12	to	to	IN
cord-260476-whfyczcj	238	13	the	the	DT
cord-260476-whfyczcj	238	14	plasma	plasma	NN
cord-260476-whfyczcj	238	15	membrane	membrane	NN
cord-260476-whfyczcj	238	16	of	of	IN
cord-260476-whfyczcj	238	17	their	-PRON-	PRP$
cord-260476-whfyczcj	238	18	host	host	NN
cord-260476-whfyczcj	238	19	cell	cell	NN
cord-260476-whfyczcj	238	20	after	after	IN
cord-260476-whfyczcj	238	21	budding	bud	VBG
cord-260476-whfyczcj	238	22	and	and	CC
cord-260476-whfyczcj	238	23	are	be	VBP
cord-260476-whfyczcj	238	24	eventually	eventually	RB
cord-260476-whfyczcj	238	25	endocytosed	endocytose	VBN
cord-260476-whfyczcj	238	26	and	and	CC
cord-260476-whfyczcj	238	27	degraded	degrade	VBN
cord-260476-whfyczcj	238	28	[	[	-LRB-
cord-260476-whfyczcj	238	29	75	75	CD
cord-260476-whfyczcj	238	30	]	]	-RRB-
cord-260476-whfyczcj	238	31	.	.	.
cord-260476-whfyczcj	239	1	The	the	DT
cord-260476-whfyczcj	239	2	cellular	cellular	JJ
cord-260476-whfyczcj	239	3	restriction	restriction	NN
cord-260476-whfyczcj	239	4	factor	factor	NN
cord-260476-whfyczcj	239	5	responsible	responsible	JJ
cord-260476-whfyczcj	239	6	for	for	IN
cord-260476-whfyczcj	239	7	the	the	DT
cord-260476-whfyczcj	239	8	block	block	NN
cord-260476-whfyczcj	239	9	of	of	IN
cord-260476-whfyczcj	239	10	virion	virion	NN
cord-260476-whfyczcj	239	11	release	release	NN
cord-260476-whfyczcj	239	12	is	be	VBZ
cord-260476-whfyczcj	239	13	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	239	14	/	/	SYM
cord-260476-whfyczcj	239	15	BST-2	BST-2	NNP
cord-260476-whfyczcj	239	16	.	.	.
cord-260476-whfyczcj	240	1	BST-2	BST-2	NNP
cord-260476-whfyczcj	240	2	is	be	VBZ
cord-260476-whfyczcj	240	3	found	find	VBN
cord-260476-whfyczcj	240	4	as	as	IN
cord-260476-whfyczcj	240	5	a	a	DT
cord-260476-whfyczcj	240	6	disulfide	disulfide	NN
cord-260476-whfyczcj	240	7	-	-	HYPH
cord-260476-whfyczcj	240	8	bond	bond	NN
cord-260476-whfyczcj	240	9	-	-	HYPH
cord-260476-whfyczcj	240	10	linked	link	VBN
cord-260476-whfyczcj	240	11	dimer	dimer	NN
cord-260476-whfyczcj	240	12	which	which	WDT
cord-260476-whfyczcj	240	13	is	be	VBZ
cord-260476-whfyczcj	240	14	anchored	anchor	VBN
cord-260476-whfyczcj	240	15	into	into	IN
cord-260476-whfyczcj	240	16	the	the	DT
cord-260476-whfyczcj	240	17	plasma	plasma	NN
cord-260476-whfyczcj	240	18	membrane	membrane	NN
cord-260476-whfyczcj	240	19	by	by	IN
cord-260476-whfyczcj	240	20	two	two	CD
cord-260476-whfyczcj	240	21	domains	domain	NNS
cord-260476-whfyczcj	240	22	:	:	:
cord-260476-whfyczcj	240	23	a	a	DT
cord-260476-whfyczcj	240	24	transmembrane	transmembrane	NN
cord-260476-whfyczcj	240	25	domain	domain	NN
cord-260476-whfyczcj	240	26	close	close	JJ
cord-260476-whfyczcj	240	27	to	to	IN
cord-260476-whfyczcj	240	28	its	-PRON-	PRP$
cord-260476-whfyczcj	240	29	N	n	CD
cord-260476-whfyczcj	240	30	-	-	HYPH
cord-260476-whfyczcj	240	31	terminus	terminus	NN
cord-260476-whfyczcj	240	32	and	and	CC
cord-260476-whfyczcj	240	33	an	an	DT
cord-260476-whfyczcj	240	34	extracellular	extracellular	JJ
cord-260476-whfyczcj	240	35	C	c	NN
cord-260476-whfyczcj	240	36	-	-	HYPH
cord-260476-whfyczcj	240	37	terminal	terminal	NN
cord-260476-whfyczcj	240	38	glycosyl	glycosyl	NN
cord-260476-whfyczcj	240	39	-	-	HYPH
cord-260476-whfyczcj	240	40	phosphatidylinositol	phosphatidylinositol	JJ
cord-260476-whfyczcj	241	1	(	(	-LRB-
cord-260476-whfyczcj	241	2	GPI)-anchor	GPI)-anchor	VBN
cord-260476-whfyczcj	242	1	(	(	-LRB-
cord-260476-whfyczcj	242	2	Figure	figure	NN
cord-260476-whfyczcj	242	3	6A	6a	CD
cord-260476-whfyczcj	242	4	)	)	-RRB-
cord-260476-whfyczcj	243	1	[	[	-LRB-
cord-260476-whfyczcj	243	2	134	134	CD
cord-260476-whfyczcj	243	3	]	]	-RRB-
cord-260476-whfyczcj	243	4	.	.	.
cord-260476-whfyczcj	244	1	These	these	DT
cord-260476-whfyczcj	244	2	two	two	CD
cord-260476-whfyczcj	244	3	domains	domain	NNS
cord-260476-whfyczcj	244	4	mediate	mediate	VBP
cord-260476-whfyczcj	244	5	virion	virion	NN
cord-260476-whfyczcj	244	6	-	-	:
cord-260476-whfyczcj	244	7	tethering	tethering	NN
cord-260476-whfyczcj	244	8	to	to	IN
cord-260476-whfyczcj	244	9	the	the	DT
cord-260476-whfyczcj	244	10	host	host	NN
cord-260476-whfyczcj	244	11	cell	cell	NN
cord-260476-whfyczcj	244	12	,	,	,
cord-260476-whfyczcj	244	13	one	one	CD
cord-260476-whfyczcj	244	14	remaining	remain	VBG
cord-260476-whfyczcj	244	15	in	in	IN
cord-260476-whfyczcj	244	16	the	the	DT
cord-260476-whfyczcj	244	17	plasma	plasma	NN
cord-260476-whfyczcj	244	18	membrane	membrane	NN
cord-260476-whfyczcj	244	19	and	and	CC
cord-260476-whfyczcj	244	20	the	the	DT
cord-260476-whfyczcj	244	21	other	other	JJ
cord-260476-whfyczcj	244	22	one	one	CD
cord-260476-whfyczcj	244	23	being	be	VBG
cord-260476-whfyczcj	244	24	inserted	insert	VBN
cord-260476-whfyczcj	244	25	into	into	IN
cord-260476-whfyczcj	244	26	the	the	DT
cord-260476-whfyczcj	244	27	viral	viral	JJ
cord-260476-whfyczcj	244	28	envelope	envelope	NN
cord-260476-whfyczcj	244	29	(	(	-LRB-
cord-260476-whfyczcj	244	30	Figure	figure	NN
cord-260476-whfyczcj	244	31	6C	6c	NN
cord-260476-whfyczcj	244	32	)	)	-RRB-
cord-260476-whfyczcj	244	33	.	.	.
cord-260476-whfyczcj	245	1	It	-PRON-	PRP
cord-260476-whfyczcj	245	2	has	have	VBZ
cord-260476-whfyczcj	245	3	been	be	VBN
cord-260476-whfyczcj	245	4	shown	show	VBN
cord-260476-whfyczcj	245	5	that	that	IN
cord-260476-whfyczcj	245	6	this	this	DT
cord-260476-whfyczcj	245	7	tethering	tethering	NN
cord-260476-whfyczcj	245	8	involves	involve	VBZ
cord-260476-whfyczcj	245	9	approximately	approximately	RB
cord-260476-whfyczcj	245	10	a	a	DT
cord-260476-whfyczcj	245	11	dozen	dozen	NN
cord-260476-whfyczcj	245	12	of	of	IN
cord-260476-whfyczcj	245	13	BST-2	BST-2	NNP
cord-260476-whfyczcj	245	14	dimers	dimer	NNS
cord-260476-whfyczcj	245	15	and	and	CC
cord-260476-whfyczcj	245	16	that	that	IN
cord-260476-whfyczcj	245	17	among	among	IN
cord-260476-whfyczcj	245	18	the	the	DT
cord-260476-whfyczcj	245	19	two	two	CD
cord-260476-whfyczcj	245	20	membrane	membrane	NN
cord-260476-whfyczcj	245	21	-	-	HYPH
cord-260476-whfyczcj	245	22	associated	associate	VBN
cord-260476-whfyczcj	245	23	domains	domain	NNS
cord-260476-whfyczcj	245	24	,	,	,
cord-260476-whfyczcj	245	25	the	the	DT
cord-260476-whfyczcj	245	26	GPI	GPI	NNP
cord-260476-whfyczcj	245	27	-	-	HYPH
cord-260476-whfyczcj	245	28	anchor	anchor	NN
cord-260476-whfyczcj	245	29	is	be	VBZ
cord-260476-whfyczcj	245	30	preferentially	preferentially	RB
cord-260476-whfyczcj	245	31	incorporated	incorporate	VBN
cord-260476-whfyczcj	245	32	into	into	IN
cord-260476-whfyczcj	245	33	budding	bud	VBG
cord-260476-whfyczcj	245	34	virions	virion	NNS
cord-260476-whfyczcj	245	35	[	[	-LRB-
cord-260476-whfyczcj	245	36	135	135	CD
cord-260476-whfyczcj	245	37	]	]	-RRB-
cord-260476-whfyczcj	245	38	.	.	.
cord-260476-whfyczcj	246	1	The	the	DT
cord-260476-whfyczcj	246	2	extracellular	extracellular	JJ
cord-260476-whfyczcj	246	3	domain	domain	NN
cord-260476-whfyczcj	246	4	of	of	IN
cord-260476-whfyczcj	246	5	BST-2	BST-2	NNP
cord-260476-whfyczcj	246	6	thereby	thereby	RB
cord-260476-whfyczcj	246	7	acts	act	VBZ
cord-260476-whfyczcj	246	8	like	like	IN
cord-260476-whfyczcj	246	9	a	a	DT
cord-260476-whfyczcj	246	10	molecular	molecular	JJ
cord-260476-whfyczcj	246	11	ruler	ruler	NN
cord-260476-whfyczcj	246	12	,	,	,
cord-260476-whfyczcj	246	13	maintaining	maintain	VBG
cord-260476-whfyczcj	246	14	the	the	DT
cord-260476-whfyczcj	246	15	virus	virus	NN
cord-260476-whfyczcj	246	16	at	at	IN
cord-260476-whfyczcj	246	17	a	a	DT
cord-260476-whfyczcj	246	18	constant	constant	JJ
cord-260476-whfyczcj	246	19	distance	distance	NN
cord-260476-whfyczcj	246	20	of	of	IN
cord-260476-whfyczcj	246	21	the	the	DT
cord-260476-whfyczcj	246	22	plasma	plasma	NN
cord-260476-whfyczcj	246	23	membrane	membrane	NN
cord-260476-whfyczcj	246	24	,	,	,
cord-260476-whfyczcj	246	25	preventing	prevent	VBG
cord-260476-whfyczcj	246	26	it	-PRON-	PRP
cord-260476-whfyczcj	246	27	from	from	IN
cord-260476-whfyczcj	246	28	disseminating	disseminate	VBG
cord-260476-whfyczcj	246	29	to	to	IN
cord-260476-whfyczcj	246	30	other	other	JJ
cord-260476-whfyczcj	246	31	target	target	NN
cord-260476-whfyczcj	246	32	cells	cell	NNS
cord-260476-whfyczcj	246	33	[	[	-LRB-
cord-260476-whfyczcj	246	34	134	134	CD
cord-260476-whfyczcj	246	35	]	]	-RRB-
cord-260476-whfyczcj	246	36	.	.	.
cord-260476-whfyczcj	247	1	The	the	DT
cord-260476-whfyczcj	247	2	viral	viral	JJ
cord-260476-whfyczcj	247	3	protein	protein	NN
cord-260476-whfyczcj	247	4	Vpu	Vpu	NNP
cord-260476-whfyczcj	247	5	counteracts	counteract	VBZ
cord-260476-whfyczcj	247	6	BST-2	BST-2	NNP
cord-260476-whfyczcj	247	7	by	by	IN
cord-260476-whfyczcj	247	8	direct	direct	JJ
cord-260476-whfyczcj	247	9	interaction	interaction	NN
cord-260476-whfyczcj	247	10	of	of	IN
cord-260476-whfyczcj	247	11	their	-PRON-	PRP$
cord-260476-whfyczcj	247	12	transmembrane	transmembrane	NN
cord-260476-whfyczcj	247	13	domains	domain	NNS
cord-260476-whfyczcj	247	14	embedded	embed	VBN
cord-260476-whfyczcj	247	15	in	in	IN
cord-260476-whfyczcj	247	16	the	the	DT
cord-260476-whfyczcj	247	17	plasma	plasma	NN
cord-260476-whfyczcj	247	18	membrane	membrane	NN
cord-260476-whfyczcj	247	19	[	[	-LRB-
cord-260476-whfyczcj	247	20	136	136	CD
cord-260476-whfyczcj	247	21	]	]	-RRB-
cord-260476-whfyczcj	247	22	.	.	.
cord-260476-whfyczcj	248	1	The	the	DT
cord-260476-whfyczcj	248	2	exact	exact	JJ
cord-260476-whfyczcj	248	3	mode	mode	NN
cord-260476-whfyczcj	248	4	of	of	IN
cord-260476-whfyczcj	248	5	action	action	NN
cord-260476-whfyczcj	248	6	of	of	IN
cord-260476-whfyczcj	248	7	Vpu	Vpu	NNP
cord-260476-whfyczcj	248	8	is	be	VBZ
cord-260476-whfyczcj	248	9	still	still	RB
cord-260476-whfyczcj	248	10	a	a	DT
cord-260476-whfyczcj	248	11	matter	matter	NN
cord-260476-whfyczcj	248	12	of	of	IN
cord-260476-whfyczcj	248	13	debate	debate	NN
cord-260476-whfyczcj	248	14	,	,	,
cord-260476-whfyczcj	248	15	but	but	CC
cord-260476-whfyczcj	248	16	it	-PRON-	PRP
cord-260476-whfyczcj	248	17	seems	seem	VBZ
cord-260476-whfyczcj	248	18	clear	clear	JJ
cord-260476-whfyczcj	248	19	now	now	RB
cord-260476-whfyczcj	248	20	that	that	IN
cord-260476-whfyczcj	248	21	Vpu	Vpu	NNP
cord-260476-whfyczcj	248	22	sequesters	sequester	VBZ
cord-260476-whfyczcj	248	23	BST-2	BST-2	NNP
cord-260476-whfyczcj	248	24	away	away	RB
cord-260476-whfyczcj	248	25	from	from	IN
cord-260476-whfyczcj	248	26	virion	virion	NN
cord-260476-whfyczcj	248	27	budding	bud	VBG
cord-260476-whfyczcj	248	28	sites	site	NNS
cord-260476-whfyczcj	248	29	,	,	,
cord-260476-whfyczcj	248	30	thereby	thereby	RB
cord-260476-whfyczcj	248	31	preventing	prevent	VBG
cord-260476-whfyczcj	248	32	it	-PRON-	PRP
cord-260476-whfyczcj	248	33	from	from	IN
cord-260476-whfyczcj	248	34	incorporation	incorporation	NN
cord-260476-whfyczcj	248	35	into	into	IN
cord-260476-whfyczcj	248	36	the	the	DT
cord-260476-whfyczcj	248	37	viral	viral	JJ
cord-260476-whfyczcj	248	38	envelope	envelope	NN
cord-260476-whfyczcj	248	39	(	(	-LRB-
cord-260476-whfyczcj	248	40	Figure	figure	NN
cord-260476-whfyczcj	248	41	6C	6c	NN
cord-260476-whfyczcj	248	42	1	1	CD
cord-260476-whfyczcj	248	43	)	)	-RRB-
cord-260476-whfyczcj	248	44	[	[	-LRB-
cord-260476-whfyczcj	248	45	77	77	CD
cord-260476-whfyczcj	248	46	,	,	,
cord-260476-whfyczcj	248	47	85	85	CD
cord-260476-whfyczcj	248	48	,	,	,
cord-260476-whfyczcj	248	49	137	137	CD
cord-260476-whfyczcj	248	50	,	,	,
cord-260476-whfyczcj	248	51	138	138	CD
cord-260476-whfyczcj	248	52	]	]	-RRB-
cord-260476-whfyczcj	248	53	.	.	.
cord-260476-whfyczcj	249	1	Several	several	JJ
cord-260476-whfyczcj	249	2	studies	study	NNS
cord-260476-whfyczcj	249	3	have	have	VBP
cord-260476-whfyczcj	249	4	shown	show	VBN
cord-260476-whfyczcj	249	5	that	that	IN
cord-260476-whfyczcj	249	6	in	in	IN
cord-260476-whfyczcj	249	7	the	the	DT
cord-260476-whfyczcj	249	8	presence	presence	NN
cord-260476-whfyczcj	249	9	of	of	IN
cord-260476-whfyczcj	249	10	Vpu	Vpu	NNP
cord-260476-whfyczcj	249	11	,	,	,
cord-260476-whfyczcj	249	12	newly	newly	RB
cord-260476-whfyczcj	249	13	synthesized	synthesize	VBN
cord-260476-whfyczcj	249	14	BST-2	BST-2	NNP
cord-260476-whfyczcj	249	15	is	be	VBZ
cord-260476-whfyczcj	249	16	sequestered	sequester	VBN
cord-260476-whfyczcj	249	17	in	in	IN
cord-260476-whfyczcj	249	18	intracellular	intracellular	JJ
cord-260476-whfyczcj	249	19	compartments	compartment	NNS
cord-260476-whfyczcj	249	20	,	,	,
cord-260476-whfyczcj	249	21	particularly	particularly	RB
cord-260476-whfyczcj	249	22	the	the	DT
cord-260476-whfyczcj	249	23	trans	trans	JJ
cord-260476-whfyczcj	249	24	-	-	JJ
cord-260476-whfyczcj	249	25	golgi	golgi	NN
cord-260476-whfyczcj	249	26	-	-	HYPH
cord-260476-whfyczcj	249	27	network	network	NN
cord-260476-whfyczcj	249	28	(	(	-LRB-
cord-260476-whfyczcj	249	29	Figure	figure	NN
cord-260476-whfyczcj	249	30	6C	6c	NN
cord-260476-whfyczcj	249	31	2	2	CD
cord-260476-whfyczcj	249	32	)	)	-RRB-
cord-260476-whfyczcj	249	33	.	.	.
cord-260476-whfyczcj	250	1	This	this	DT
cord-260476-whfyczcj	250	2	finally	finally	RB
cord-260476-whfyczcj	250	3	results	result	VBZ
cord-260476-whfyczcj	250	4	in	in	IN
cord-260476-whfyczcj	250	5	the	the	DT
cord-260476-whfyczcj	250	6	downregulation	downregulation	NN
cord-260476-whfyczcj	250	7	of	of	IN
cord-260476-whfyczcj	250	8	surface	surface	NN
cord-260476-whfyczcj	250	9	levels	level	NNS
cord-260476-whfyczcj	250	10	of	of	IN
cord-260476-whfyczcj	250	11	BST-2	BST-2	NNP
cord-260476-whfyczcj	250	12	,	,	,
cord-260476-whfyczcj	250	13	thereby	thereby	RB
cord-260476-whfyczcj	250	14	allowing	allow	VBG
cord-260476-whfyczcj	250	15	normal	normal	JJ
cord-260476-whfyczcj	250	16	rates	rate	NNS
cord-260476-whfyczcj	250	17	of	of	IN
cord-260476-whfyczcj	250	18	virion	virion	NN
cord-260476-whfyczcj	250	19	release	release	NN
cord-260476-whfyczcj	250	20	in	in	IN
cord-260476-whfyczcj	250	21	the	the	DT
cord-260476-whfyczcj	250	22	presence	presence	NN
cord-260476-whfyczcj	250	23	of	of	IN
cord-260476-whfyczcj	250	24	Vpu	Vpu	NNP
cord-260476-whfyczcj	250	25	[	[	-LRB-
cord-260476-whfyczcj	250	26	77	77	CD
cord-260476-whfyczcj	250	27	,	,	,
cord-260476-whfyczcj	250	28	85	85	CD
cord-260476-whfyczcj	250	29	,	,	,
cord-260476-whfyczcj	250	30	137	137	CD
cord-260476-whfyczcj	250	31	,	,	,
cord-260476-whfyczcj	250	32	138	138	CD
cord-260476-whfyczcj	250	33	]	]	-RRB-
cord-260476-whfyczcj	250	34	.	.	.
cord-260476-whfyczcj	251	1	BST-2	BST-2	NNP
cord-260476-whfyczcj	251	2	is	be	VBZ
cord-260476-whfyczcj	251	3	constitutively	constitutively	RB
cord-260476-whfyczcj	251	4	regulated	regulate	VBN
cord-260476-whfyczcj	251	5	by	by	IN
cord-260476-whfyczcj	251	6	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	251	7	and	and	CC
cord-260476-whfyczcj	251	8	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	251	9	degradation	degradation	NN
cord-260476-whfyczcj	251	10	mediated	mediate	VBN
cord-260476-whfyczcj	251	11	by	by	IN
cord-260476-whfyczcj	251	12	the	the	DT
cord-260476-whfyczcj	251	13	cellular	cellular	JJ
cord-260476-whfyczcj	251	14	E3	e3	NN
cord-260476-whfyczcj	251	15	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	251	16	ligases	ligase	NNS
cord-260476-whfyczcj	251	17	March8	March8	NNP
cord-260476-whfyczcj	251	18	and	and	CC
cord-260476-whfyczcj	251	19	NEDD4	NEDD4	NNP
cord-260476-whfyczcj	252	1	(	(	-LRB-
cord-260476-whfyczcj	252	2	Neural	neural	JJ
cord-260476-whfyczcj	252	3	precursor	precursor	NN
cord-260476-whfyczcj	252	4	cell	cell	NN
cord-260476-whfyczcj	252	5	Expressed	express	VBN
cord-260476-whfyczcj	252	6	Developmentally	developmentally	RB
cord-260476-whfyczcj	252	7	Down	down	RB
cord-260476-whfyczcj	252	8	-	-	HYPH
cord-260476-whfyczcj	252	9	regulated	regulate	VBN
cord-260476-whfyczcj	252	10	protein	protein	NN
cord-260476-whfyczcj	252	11	4	4	CD
cord-260476-whfyczcj	252	12	)	)	-RRB-
cord-260476-whfyczcj	253	1	[	[	-LRB-
cord-260476-whfyczcj	253	2	139	139	CD
cord-260476-whfyczcj	253	3	]	]	-RRB-
cord-260476-whfyczcj	253	4	.	.	.
cord-260476-whfyczcj	254	1	It	-PRON-	PRP
cord-260476-whfyczcj	254	2	is	be	VBZ
cord-260476-whfyczcj	254	3	still	still	RB
cord-260476-whfyczcj	254	4	a	a	DT
cord-260476-whfyczcj	254	5	matter	matter	NN
cord-260476-whfyczcj	254	6	of	of	IN
cord-260476-whfyczcj	254	7	debate	debate	NN
cord-260476-whfyczcj	254	8	however	however	RB
cord-260476-whfyczcj	254	9	,	,	,
cord-260476-whfyczcj	254	10	whether	whether	IN
cord-260476-whfyczcj	254	11	Vpu	Vpu	NNP
cord-260476-whfyczcj	254	12	also	also	RB
cord-260476-whfyczcj	254	13	uses	use	VBZ
cord-260476-whfyczcj	254	14	the	the	DT
cord-260476-whfyczcj	254	15	endo	endo	NN
cord-260476-whfyczcj	254	16	-	-	HYPH
cord-260476-whfyczcj	254	17	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	254	18	system	system	NN
cord-260476-whfyczcj	254	19	for	for	IN
cord-260476-whfyczcj	254	20	BST-2	BST-2	NNP
cord-260476-whfyczcj	254	21	counteraction	counteraction	NN
cord-260476-whfyczcj	254	22	.	.	.
cord-260476-whfyczcj	255	1	The	the	DT
cord-260476-whfyczcj	255	2	E3-ubiquitin	E3-ubiquitin	NNS
cord-260476-whfyczcj	255	3	ligase	ligase	NN
cord-260476-whfyczcj	255	4	adaptor	adaptor	NN
cord-260476-whfyczcj	255	5	β	β	NN
cord-260476-whfyczcj	255	6	-	-	HYPH
cord-260476-whfyczcj	255	7	TrCP	TrCP	NNP
cord-260476-whfyczcj	255	8	is	be	VBZ
cord-260476-whfyczcj	255	9	known	know	VBN
cord-260476-whfyczcj	255	10	to	to	TO
cord-260476-whfyczcj	255	11	be	be	VB
cord-260476-whfyczcj	255	12	recruited	recruit	VBN
cord-260476-whfyczcj	255	13	by	by	IN
cord-260476-whfyczcj	255	14	the	the	DT
cord-260476-whfyczcj	255	15	cytoplasmic	cytoplasmic	JJ
cord-260476-whfyczcj	255	16	DSGxxS	DSGxxS	NNP
cord-260476-whfyczcj	255	17	motif	motif	NN
cord-260476-whfyczcj	255	18	of	of	IN
cord-260476-whfyczcj	255	19	Vpu	Vpu	NNP
cord-260476-whfyczcj	255	20	(	(	-LRB-
cord-260476-whfyczcj	255	21	Figure	figure	NN
cord-260476-whfyczcj	255	22	6B	6b	CD
cord-260476-whfyczcj	255	23	)	)	-RRB-
cord-260476-whfyczcj	255	24	[	[	-LRB-
cord-260476-whfyczcj	255	25	140	140	CD
cord-260476-whfyczcj	255	26	]	]	-RRB-
cord-260476-whfyczcj	255	27	,	,	,
cord-260476-whfyczcj	255	28	which	which	WDT
cord-260476-whfyczcj	255	29	might	may	MD
cord-260476-whfyczcj	255	30	lead	lead	VB
cord-260476-whfyczcj	255	31	to	to	IN
cord-260476-whfyczcj	255	32	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	255	33	of	of	IN
cord-260476-whfyczcj	255	34	BST-2	BST-2	NNP
cord-260476-whfyczcj	255	35	followed	follow	VBN
cord-260476-whfyczcj	255	36	by	by	IN
cord-260476-whfyczcj	255	37	its	-PRON-	PRP$
cord-260476-whfyczcj	255	38	degradation	degradation	NN
cord-260476-whfyczcj	255	39	in	in	IN
cord-260476-whfyczcj	255	40	the	the	DT
cord-260476-whfyczcj	255	41	endo	endo	NN
cord-260476-whfyczcj	255	42	-	-	HYPH
cord-260476-whfyczcj	255	43	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	255	44	system	system	NN
cord-260476-whfyczcj	255	45	(	(	-LRB-
cord-260476-whfyczcj	255	46	Figure	figure	NN
cord-260476-whfyczcj	255	47	6C	6c	NN
cord-260476-whfyczcj	255	48	3	3	CD
cord-260476-whfyczcj	255	49	)	)	-RRB-
cord-260476-whfyczcj	255	50	[	[	-LRB-
cord-260476-whfyczcj	255	51	137	137	CD
cord-260476-whfyczcj	255	52	,	,	,
cord-260476-whfyczcj	255	53	141	141	CD
cord-260476-whfyczcj	255	54	]	]	-RRB-
cord-260476-whfyczcj	255	55	.	.	.
cord-260476-whfyczcj	256	1	Even	even	RB
cord-260476-whfyczcj	256	2	though	though	IN
cord-260476-whfyczcj	256	3	the	the	DT
cord-260476-whfyczcj	256	4	interaction	interaction	NN
cord-260476-whfyczcj	256	5	of	of	IN
cord-260476-whfyczcj	256	6	Vpu	Vpu	NNP
cord-260476-whfyczcj	256	7	with	with	IN
cord-260476-whfyczcj	256	8	β	β	NN
cord-260476-whfyczcj	256	9	-	-	HYPH
cord-260476-whfyczcj	256	10	TrCP	TrCP	NNP
cord-260476-whfyczcj	256	11	,	,	,
cord-260476-whfyczcj	256	12	as	as	RB
cord-260476-whfyczcj	256	13	well	well	RB
cord-260476-whfyczcj	256	14	as	as	IN
cord-260476-whfyczcj	256	15	the	the	DT
cord-260476-whfyczcj	256	16	capacity	capacity	NN
cord-260476-whfyczcj	256	17	of	of	IN
cord-260476-whfyczcj	256	18	β	β	NN
cord-260476-whfyczcj	256	19	-	-	HYPH
cord-260476-whfyczcj	256	20	TrCP	trcp	NN
cord-260476-whfyczcj	256	21	to	to	TO
cord-260476-whfyczcj	256	22	recruit	recruit	VB
cord-260476-whfyczcj	256	23	an	an	DT
cord-260476-whfyczcj	256	24	E3-ubiquitin	e3-ubiquitin	NN
cord-260476-whfyczcj	256	25	ligase	ligase	NN
cord-260476-whfyczcj	256	26	seem	seem	VB
cord-260476-whfyczcj	256	27	to	to	TO
cord-260476-whfyczcj	256	28	be	be	VB
cord-260476-whfyczcj	256	29	required	require	VBN
cord-260476-whfyczcj	256	30	for	for	IN
cord-260476-whfyczcj	256	31	BST-2	BST-2	NNP
cord-260476-whfyczcj	256	32	counteraction	counteraction	NN
cord-260476-whfyczcj	256	33	by	by	IN
cord-260476-whfyczcj	256	34	Vpu	Vpu	NNP
cord-260476-whfyczcj	256	35	[	[	-LRB-
cord-260476-whfyczcj	256	36	137	137	CD
cord-260476-whfyczcj	256	37	,	,	,
cord-260476-whfyczcj	256	38	142	142	CD
cord-260476-whfyczcj	256	39	,	,	,
cord-260476-whfyczcj	256	40	143	143	CD
cord-260476-whfyczcj	256	41	]	]	-RRB-
cord-260476-whfyczcj	256	42	,	,	,
cord-260476-whfyczcj	256	43	conflicting	conflict	VBG
cord-260476-whfyczcj	256	44	data	datum	NNS
cord-260476-whfyczcj	256	45	have	have	VBP
cord-260476-whfyczcj	256	46	also	also	RB
cord-260476-whfyczcj	256	47	been	be	VBN
cord-260476-whfyczcj	256	48	reported	report	VBN
cord-260476-whfyczcj	256	49	[	[	-LRB-
cord-260476-whfyczcj	256	50	144	144	CD
cord-260476-whfyczcj	256	51	]	]	-RRB-
cord-260476-whfyczcj	256	52	[	[	-LRB-
cord-260476-whfyczcj	256	53	145	145	CD
cord-260476-whfyczcj	256	54	]	]	-RRB-
cord-260476-whfyczcj	256	55	[	[	-LRB-
cord-260476-whfyczcj	256	56	146	146	CD
cord-260476-whfyczcj	256	57	]	]	-RRB-
cord-260476-whfyczcj	256	58	.	.	.
cord-260476-whfyczcj	257	1	Certain	certain	JJ
cord-260476-whfyczcj	257	2	components	component	NNS
cord-260476-whfyczcj	257	3	of	of	IN
cord-260476-whfyczcj	257	4	the	the	DT
cord-260476-whfyczcj	257	5	autophagy	autophagy	NN
cord-260476-whfyczcj	257	6	pathway	pathway	NN
cord-260476-whfyczcj	257	7	,	,	,
cord-260476-whfyczcj	257	8	as	as	RB
cord-260476-whfyczcj	257	9	well	well	RB
cord-260476-whfyczcj	257	10	as	as	IN
cord-260476-whfyczcj	257	11	clathrin	clathrin	NN
cord-260476-whfyczcj	257	12	adaptors	adaptor	NNS
cord-260476-whfyczcj	257	13	AP-1	AP-1	NNP
cord-260476-whfyczcj	257	14	and	and	CC
cord-260476-whfyczcj	257	15	2	2	CD
cord-260476-whfyczcj	257	16	and	and	CC
cord-260476-whfyczcj	257	17	components	component	NNS
cord-260476-whfyczcj	257	18	of	of	IN
cord-260476-whfyczcj	257	19	the	the	DT
cord-260476-whfyczcj	257	20	ESCRT	ESCRT	NNP
cord-260476-whfyczcj	257	21	system	system	NN
cord-260476-whfyczcj	257	22	might	may	MD
cord-260476-whfyczcj	257	23	also	also	RB
cord-260476-whfyczcj	257	24	be	be	VB
cord-260476-whfyczcj	257	25	involved	involve	VBN
cord-260476-whfyczcj	257	26	in	in	IN
cord-260476-whfyczcj	257	27	the	the	DT
cord-260476-whfyczcj	257	28	downregulation	downregulation	NN
cord-260476-whfyczcj	257	29	of	of	IN
cord-260476-whfyczcj	257	30	BST-2	BST-2	NNP
cord-260476-whfyczcj	257	31	by	by	IN
cord-260476-whfyczcj	257	32	Vpu	Vpu	NNP
cord-260476-whfyczcj	257	33	,	,	,
cord-260476-whfyczcj	257	34	which	which	WDT
cord-260476-whfyczcj	257	35	would	would	MD
cord-260476-whfyczcj	257	36	corroborate	corroborate	VB
cord-260476-whfyczcj	257	37	transport	transport	NN
cord-260476-whfyczcj	257	38	of	of	IN
cord-260476-whfyczcj	257	39	BST-2	BST-2	NNP
cord-260476-whfyczcj	257	40	in	in	IN
cord-260476-whfyczcj	257	41	the	the	DT
cord-260476-whfyczcj	257	42	endosomal	endosomal	NNP
cord-260476-whfyczcj	257	43	system	system	NN
cord-260476-whfyczcj	257	44	[	[	-LRB-
cord-260476-whfyczcj	257	45	137	137	CD
cord-260476-whfyczcj	257	46	,	,	,
cord-260476-whfyczcj	257	47	[	[	-LRB-
cord-260476-whfyczcj	257	48	147	147	CD
cord-260476-whfyczcj	257	49	]	]	-RRB-
cord-260476-whfyczcj	257	50	[	[	-LRB-
cord-260476-whfyczcj	257	51	148	148	CD
cord-260476-whfyczcj	257	52	]	]	-RRB-
cord-260476-whfyczcj	257	53	[	[	-LRB-
cord-260476-whfyczcj	257	54	149	149	CD
cord-260476-whfyczcj	257	55	]	]	-RRB-
cord-260476-whfyczcj	257	56	.	.	.
cord-260476-whfyczcj	258	1	However	however	RB
cord-260476-whfyczcj	258	2	,	,	,
cord-260476-whfyczcj	258	3	degradation	degradation	NN
cord-260476-whfyczcj	258	4	of	of	IN
cord-260476-whfyczcj	258	5	BST-2	BST-2	NNP
cord-260476-whfyczcj	258	6	might	may	MD
cord-260476-whfyczcj	258	7	not	not	RB
cord-260476-whfyczcj	258	8	be	be	VB
cord-260476-whfyczcj	258	9	absolutely	absolutely	RB
cord-260476-whfyczcj	258	10	required	require	VBN
cord-260476-whfyczcj	258	11	for	for	IN
cord-260476-whfyczcj	258	12	viral	viral	JJ
cord-260476-whfyczcj	258	13	counteraction	counteraction	NN
cord-260476-whfyczcj	258	14	of	of	IN
cord-260476-whfyczcj	258	15	BST-2	BST-2	NNP
cord-260476-whfyczcj	258	16	,	,	,
cord-260476-whfyczcj	258	17	since	since	IN
cord-260476-whfyczcj	258	18	Vpu	Vpu	NNP
cord-260476-whfyczcj	258	19	is	be	VBZ
cord-260476-whfyczcj	258	20	capable	capable	JJ
cord-260476-whfyczcj	258	21	of	of	IN
cord-260476-whfyczcj	258	22	intracellular	intracellular	JJ
cord-260476-whfyczcj	258	23	sequestration	sequestration	NN
cord-260476-whfyczcj	258	24	of	of	IN
cord-260476-whfyczcj	258	25	BST-2	BST-2	NNP
cord-260476-whfyczcj	258	26	independently	independently	RB
cord-260476-whfyczcj	258	27	of	of	IN
cord-260476-whfyczcj	258	28	its	-PRON-	PRP$
cord-260476-whfyczcj	258	29	degradation	degradation	NN
cord-260476-whfyczcj	258	30	[	[	-LRB-
cord-260476-whfyczcj	258	31	85	85	CD
cord-260476-whfyczcj	258	32	,	,	,
cord-260476-whfyczcj	258	33	138	138	CD
cord-260476-whfyczcj	258	34	]	]	-RRB-
cord-260476-whfyczcj	258	35	.	.	.
cord-260476-whfyczcj	259	1	The	the	DT
cord-260476-whfyczcj	259	2	guanylate	guanylate	NN
cord-260476-whfyczcj	259	3	binding	bind	VBG
cord-260476-whfyczcj	259	4	protein	protein	NN
cord-260476-whfyczcj	259	5	5	5	CD
cord-260476-whfyczcj	259	6	(	(	-LRB-
cord-260476-whfyczcj	259	7	GBP5	GBP5	NNP
cord-260476-whfyczcj	259	8	)	)	-RRB-
cord-260476-whfyczcj	259	9	has	have	VBZ
cord-260476-whfyczcj	259	10	very	very	RB
cord-260476-whfyczcj	259	11	recently	recently	RB
cord-260476-whfyczcj	259	12	been	be	VBN
cord-260476-whfyczcj	259	13	discovered	discover	VBN
cord-260476-whfyczcj	259	14	as	as	IN
cord-260476-whfyczcj	259	15	a	a	DT
cord-260476-whfyczcj	259	16	new	new	JJ
cord-260476-whfyczcj	259	17	restriction	restriction	NN
cord-260476-whfyczcj	259	18	factor	factor	NN
cord-260476-whfyczcj	259	19	of	of	IN
cord-260476-whfyczcj	259	20	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	259	21	infection	infection	NN
cord-260476-whfyczcj	259	22	,	,	,
cord-260476-whfyczcj	259	23	that	that	WDT
cord-260476-whfyczcj	259	24	interferes	interfere	VBZ
cord-260476-whfyczcj	259	25	with	with	IN
cord-260476-whfyczcj	259	26	viral	viral	JJ
cord-260476-whfyczcj	259	27	Env	Env	NNP
cord-260476-whfyczcj	259	28	proteins	protein	NNS
cord-260476-whfyczcj	259	29	,	,	,
cord-260476-whfyczcj	259	30	thereby	thereby	RB
cord-260476-whfyczcj	259	31	decreasing	decrease	VBG
cord-260476-whfyczcj	259	32	infectivity	infectivity	NN
cord-260476-whfyczcj	259	33	of	of	IN
cord-260476-whfyczcj	259	34	produced	produce	VBN
cord-260476-whfyczcj	259	35	virions	virion	NNS
cord-260476-whfyczcj	259	36	[	[	-LRB-
cord-260476-whfyczcj	259	37	150	150	CD
cord-260476-whfyczcj	259	38	,	,	,
cord-260476-whfyczcj	259	39	151	151	CD
cord-260476-whfyczcj	259	40	]	]	-RRB-
cord-260476-whfyczcj	259	41	.	.	.
cord-260476-whfyczcj	260	1	As	as	IN
cord-260476-whfyczcj	260	2	Vpu	Vpu	NNP
cord-260476-whfyczcj	260	3	and	and	CC
cord-260476-whfyczcj	260	4	Env	Env	NNP
cord-260476-whfyczcj	260	5	are	be	VBP
cord-260476-whfyczcj	260	6	expressed	express	VBN
cord-260476-whfyczcj	260	7	from	from	IN
cord-260476-whfyczcj	260	8	the	the	DT
cord-260476-whfyczcj	260	9	same	same	JJ
cord-260476-whfyczcj	260	10	transcript	transcript	NN
cord-260476-whfyczcj	260	11	by	by	IN
cord-260476-whfyczcj	260	12	leaky	leaky	JJ
cord-260476-whfyczcj	260	13	scanning	scanning	NN
cord-260476-whfyczcj	260	14	,	,	,
cord-260476-whfyczcj	260	15	the	the	DT
cord-260476-whfyczcj	260	16	loss	loss	NN
cord-260476-whfyczcj	260	17	of	of	IN
cord-260476-whfyczcj	260	18	Vpu	Vpu	NNP
cord-260476-whfyczcj	260	19	expression	expression	NN
cord-260476-whfyczcj	260	20	can	can	MD
cord-260476-whfyczcj	260	21	in	in	IN
cord-260476-whfyczcj	260	22	this	this	DT
cord-260476-whfyczcj	260	23	case	case	NN
cord-260476-whfyczcj	260	24	lead	lead	VB
cord-260476-whfyczcj	260	25	to	to	IN
cord-260476-whfyczcj	260	26	an	an	DT
cord-260476-whfyczcj	260	27	increase	increase	NN
cord-260476-whfyczcj	260	28	of	of	IN
cord-260476-whfyczcj	260	29	Env	Env	NNP
cord-260476-whfyczcj	260	30	expression	expression	NN
cord-260476-whfyczcj	260	31	,	,	,
cord-260476-whfyczcj	260	32	as	as	IN
cord-260476-whfyczcj	260	33	observed	observe	VBN
cord-260476-whfyczcj	260	34	in	in	IN
cord-260476-whfyczcj	260	35	the	the	DT
cord-260476-whfyczcj	260	36	macrophage	macrophage	NN
cord-260476-whfyczcj	260	37	tropic	tropic	NNP
cord-260476-whfyczcj	260	38	AD8	AD8	NNP
cord-260476-whfyczcj	260	39	isolate	isolate	VBP
cord-260476-whfyczcj	260	40	[	[	-LRB-
cord-260476-whfyczcj	260	41	152	152	CD
cord-260476-whfyczcj	260	42	]	]	-RRB-
cord-260476-whfyczcj	260	43	,	,	,
cord-260476-whfyczcj	260	44	allowing	allow	VBG
cord-260476-whfyczcj	260	45	the	the	DT
cord-260476-whfyczcj	260	46	virus	virus	NN
cord-260476-whfyczcj	260	47	to	to	TO
cord-260476-whfyczcj	260	48	partly	partly	RB
cord-260476-whfyczcj	260	49	overcome	overcome	VB
cord-260476-whfyczcj	260	50	GBP5	GBP5	NNP
cord-260476-whfyczcj	260	51	restriction	restriction	NN
cord-260476-whfyczcj	260	52	.	.	.
cord-260476-whfyczcj	261	1	Surprisingly	surprisingly	RB
cord-260476-whfyczcj	261	2	,	,	,
cord-260476-whfyczcj	261	3	such	such	JJ
cord-260476-whfyczcj	261	4	Vpu	Vpu	NNP
cord-260476-whfyczcj	261	5	mutants	mutant	NNS
cord-260476-whfyczcj	261	6	seem	seem	VBP
cord-260476-whfyczcj	261	7	to	to	TO
cord-260476-whfyczcj	261	8	occur	occur	VB
cord-260476-whfyczcj	261	9	frequently	frequently	RB
cord-260476-whfyczcj	261	10	despite	despite	IN
cord-260476-whfyczcj	261	11	the	the	DT
cord-260476-whfyczcj	261	12	presence	presence	NN
cord-260476-whfyczcj	261	13	of	of	IN
cord-260476-whfyczcj	261	14	BST-2	BST-2	NNP
cord-260476-whfyczcj	261	15	.	.	.
cord-260476-whfyczcj	262	1	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	262	2	and	and	CC
cord-260476-whfyczcj	262	3	SIV	SIV	NNP
cord-260476-whfyczcj	262	4	are	be	VBP
cord-260476-whfyczcj	262	5	also	also	RB
cord-260476-whfyczcj	262	6	counteracted	counteract	VBN
cord-260476-whfyczcj	262	7	by	by	IN
cord-260476-whfyczcj	262	8	BST-2	BST-2	NNP
cord-260476-whfyczcj	262	9	proteins	protein	NNS
cord-260476-whfyczcj	262	10	expressed	express	VBN
cord-260476-whfyczcj	262	11	by	by	IN
cord-260476-whfyczcj	262	12	their	-PRON-	PRP$
cord-260476-whfyczcj	262	13	respective	respective	JJ
cord-260476-whfyczcj	262	14	host	host	NN
cord-260476-whfyczcj	262	15	species	specie	NNS
cord-260476-whfyczcj	262	16	in	in	IN
cord-260476-whfyczcj	262	17	a	a	DT
cord-260476-whfyczcj	262	18	species	species	NN
cord-260476-whfyczcj	262	19	-	-	HYPH
cord-260476-whfyczcj	262	20	dependent	dependent	JJ
cord-260476-whfyczcj	262	21	manner	manner	NN
cord-260476-whfyczcj	262	22	,	,	,
cord-260476-whfyczcj	262	23	but	but	CC
cord-260476-whfyczcj	262	24	some	some	DT
cord-260476-whfyczcj	262	25	of	of	IN
cord-260476-whfyczcj	262	26	them	-PRON-	PRP
cord-260476-whfyczcj	262	27	lack	lack	VBP
cord-260476-whfyczcj	262	28	Vpu	Vpu	NNP
cord-260476-whfyczcj	262	29	to	to	TO
cord-260476-whfyczcj	262	30	counteract	counteract	VB
cord-260476-whfyczcj	262	31	this	this	DT
cord-260476-whfyczcj	262	32	mechanism	mechanism	NN
cord-260476-whfyczcj	262	33	.	.	.
cord-260476-whfyczcj	263	1	It	-PRON-	PRP
cord-260476-whfyczcj	263	2	has	have	VBZ
cord-260476-whfyczcj	263	3	been	be	VBN
cord-260476-whfyczcj	263	4	shown	show	VBN
cord-260476-whfyczcj	263	5	that	that	IN
cord-260476-whfyczcj	263	6	the	the	DT
cord-260476-whfyczcj	263	7	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	263	8	Env	Env	NNP
cord-260476-whfyczcj	263	9	protein	protein	NN
cord-260476-whfyczcj	263	10	can	can	MD
cord-260476-whfyczcj	263	11	enhance	enhance	VB
cord-260476-whfyczcj	263	12	virion	virion	NN
cord-260476-whfyczcj	263	13	release	release	NN
cord-260476-whfyczcj	263	14	in	in	IN
cord-260476-whfyczcj	263	15	the	the	DT
cord-260476-whfyczcj	263	16	presence	presence	NN
cord-260476-whfyczcj	263	17	of	of	IN
cord-260476-whfyczcj	263	18	BST-2	BST-2	NNP
cord-260476-whfyczcj	263	19	thereby	thereby	RB
cord-260476-whfyczcj	263	20	substituting	substitute	VBG
cord-260476-whfyczcj	263	21	for	for	IN
cord-260476-whfyczcj	263	22	Vpu	Vpu	NNP
cord-260476-whfyczcj	263	23	[	[	-LRB-
cord-260476-whfyczcj	263	24	153	153	CD
cord-260476-whfyczcj	263	25	,	,	,
cord-260476-whfyczcj	263	26	154	154	CD
cord-260476-whfyczcj	263	27	]	]	-RRB-
cord-260476-whfyczcj	263	28	.	.	.
cord-260476-whfyczcj	264	1	Certain	certain	JJ
cord-260476-whfyczcj	264	2	SIV	SIV	NNP
cord-260476-whfyczcj	264	3	strains	strain	NNS
cord-260476-whfyczcj	264	4	,	,	,
cord-260476-whfyczcj	264	5	like	like	IN
cord-260476-whfyczcj	264	6	SIVagm	SIVagm	NNP
cord-260476-whfyczcj	264	7	,	,	,
cord-260476-whfyczcj	264	8	SIVblu	SIVblu	NNP
cord-260476-whfyczcj	264	9	and	and	CC
cord-260476-whfyczcj	264	10	SIVmac	SIVmac	NNP
cord-260476-whfyczcj	264	11	also	also	RB
cord-260476-whfyczcj	264	12	lack	lack	VBP
cord-260476-whfyczcj	264	13	the	the	DT
cord-260476-whfyczcj	264	14	Vpu	Vpu	NNP
cord-260476-whfyczcj	264	15	gene	gene	NN
cord-260476-whfyczcj	264	16	and	and	CC
cord-260476-whfyczcj	264	17	rely	rely	VB
cord-260476-whfyczcj	264	18	on	on	IN
cord-260476-whfyczcj	264	19	the	the	DT
cord-260476-whfyczcj	264	20	accessory	accessory	NN
cord-260476-whfyczcj	264	21	protein	protein	NN
cord-260476-whfyczcj	264	22	Nef	Nef	NNP
cord-260476-whfyczcj	264	23	to	to	TO
cord-260476-whfyczcj	264	24	counteract	counteract	VB
cord-260476-whfyczcj	264	25	BST-2	BST-2	NNP
cord-260476-whfyczcj	264	26	.	.	.
cord-260476-whfyczcj	265	1	Other	other	JJ
cord-260476-whfyczcj	265	2	SIV	SIV	NNP
cord-260476-whfyczcj	265	3	strains	strain	NNS
cord-260476-whfyczcj	265	4	like	like	IN
cord-260476-whfyczcj	265	5	SIVmon	SIVmon	NNP
cord-260476-whfyczcj	265	6	,	,	,
cord-260476-whfyczcj	265	7	SIVmus	SIVmus	NNP
cord-260476-whfyczcj	265	8	,	,	,
cord-260476-whfyczcj	265	9	SIVgsn	SIVgsn	NNP
cord-260476-whfyczcj	265	10	and	and	CC
cord-260476-whfyczcj	265	11	SIVden	SIVden	NNP
cord-260476-whfyczcj	265	12	express	express	NNP
cord-260476-whfyczcj	265	13	Vpu	Vpu	NNP
cord-260476-whfyczcj	265	14	and	and	CC
cord-260476-whfyczcj	265	15	use	use	VB
cord-260476-whfyczcj	265	16	it	-PRON-	PRP
cord-260476-whfyczcj	265	17	to	to	TO
cord-260476-whfyczcj	265	18	counteract	counteract	VB
cord-260476-whfyczcj	265	19	BST-2	BST-2	NNP
cord-260476-whfyczcj	265	20	.	.	.
cord-260476-whfyczcj	266	1	Even	even	RB
cord-260476-whfyczcj	266	2	though	though	IN
cord-260476-whfyczcj	266	3	SIVgor	SIVgor	NNP
cord-260476-whfyczcj	266	4	and	and	CC
cord-260476-whfyczcj	266	5	SIVcpz	SIVcpz	NNP
cord-260476-whfyczcj	266	6	express	express	NNP
cord-260476-whfyczcj	266	7	Vpu	Vpu	NNP
cord-260476-whfyczcj	266	8	,	,	,
cord-260476-whfyczcj	266	9	Nef	Nef	NNP
cord-260476-whfyczcj	266	10	seems	seem	VBZ
cord-260476-whfyczcj	266	11	to	to	TO
cord-260476-whfyczcj	266	12	take	take	VB
cord-260476-whfyczcj	266	13	over	over	RP
cord-260476-whfyczcj	266	14	the	the	DT
cord-260476-whfyczcj	266	15	role	role	NN
cord-260476-whfyczcj	266	16	of	of	IN
cord-260476-whfyczcj	266	17	BST-2	BST-2	NNP
cord-260476-whfyczcj	266	18	counteraction	counteraction	NN
cord-260476-whfyczcj	266	19	.	.	.
cord-260476-whfyczcj	267	1	This	this	DT
cord-260476-whfyczcj	267	2	gives	give	VBZ
cord-260476-whfyczcj	267	3	interesting	interesting	JJ
cord-260476-whfyczcj	267	4	clues	clue	NNS
cord-260476-whfyczcj	267	5	about	about	IN
cord-260476-whfyczcj	267	6	the	the	DT
cord-260476-whfyczcj	267	7	evolution	evolution	NN
cord-260476-whfyczcj	267	8	of	of	IN
cord-260476-whfyczcj	267	9	HIV	HIV	NNP
cord-260476-whfyczcj	267	10	and	and	CC
cord-260476-whfyczcj	267	11	SIV	SIV	NNP
cord-260476-whfyczcj	267	12	strains	strain	NNS
cord-260476-whfyczcj	267	13	[	[	-LRB-
cord-260476-whfyczcj	267	14	155	155	CD
cord-260476-whfyczcj	267	15	]	]	-RRB-
cord-260476-whfyczcj	267	16	[	[	-LRB-
cord-260476-whfyczcj	267	17	156	156	CD
cord-260476-whfyczcj	267	18	]	]	-RRB-
cord-260476-whfyczcj	267	19	[	[	-LRB-
cord-260476-whfyczcj	267	20	157	157	CD
cord-260476-whfyczcj	267	21	]	]	-RRB-
cord-260476-whfyczcj	267	22	.	.	.
cord-260476-whfyczcj	268	1	Vpu	Vpu	NNP
cord-260476-whfyczcj	268	2	can	can	MD
cord-260476-whfyczcj	268	3	also	also	RB
cord-260476-whfyczcj	268	4	induce	induce	VB
cord-260476-whfyczcj	268	5	BST-2	BST-2	NNP
cord-260476-whfyczcj	268	6	degradation	degradation	NN
cord-260476-whfyczcj	268	7	in	in	IN
cord-260476-whfyczcj	268	8	the	the	DT
cord-260476-whfyczcj	268	9	endo	endo	NN
cord-260476-whfyczcj	268	10	-	-	HYPH
cord-260476-whfyczcj	268	11	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	268	12	pathway	pathway	NN
cord-260476-whfyczcj	268	13	.	.	.
cord-260476-whfyczcj	269	1	The	the	DT
cord-260476-whfyczcj	269	2	UPS	UPS	NNP
cord-260476-whfyczcj	269	3	is	be	VBZ
cord-260476-whfyczcj	269	4	hijacked	hijack	VBN
cord-260476-whfyczcj	269	5	by	by	IN
cord-260476-whfyczcj	269	6	HIV	HIV	NNP
cord-260476-whfyczcj	269	7	and	and	CC
cord-260476-whfyczcj	269	8	plays	play	VBZ
cord-260476-whfyczcj	269	9	an	an	DT
cord-260476-whfyczcj	269	10	important	important	JJ
cord-260476-whfyczcj	269	11	role	role	NN
cord-260476-whfyczcj	269	12	for	for	IN
cord-260476-whfyczcj	269	13	the	the	DT
cord-260476-whfyczcj	269	14	viral	viral	JJ
cord-260476-whfyczcj	269	15	defense	defense	NN
cord-260476-whfyczcj	269	16	against	against	IN
cord-260476-whfyczcj	269	17	multiple	multiple	JJ
cord-260476-whfyczcj	269	18	cellular	cellular	JJ
cord-260476-whfyczcj	269	19	restriction	restriction	NN
cord-260476-whfyczcj	269	20	mechanisms	mechanism	NNS
cord-260476-whfyczcj	269	21	.	.	.
cord-260476-whfyczcj	270	1	Apart	apart	RB
cord-260476-whfyczcj	270	2	from	from	IN
cord-260476-whfyczcj	270	3	restriction	restriction	NN
cord-260476-whfyczcj	270	4	factors	factor	NNS
cord-260476-whfyczcj	270	5	,	,	,
cord-260476-whfyczcj	270	6	several	several	JJ
cord-260476-whfyczcj	270	7	other	other	JJ
cord-260476-whfyczcj	270	8	cellular	cellular	JJ
cord-260476-whfyczcj	270	9	proteins	protein	NNS
cord-260476-whfyczcj	270	10	can	can	MD
cord-260476-whfyczcj	270	11	also	also	RB
cord-260476-whfyczcj	270	12	be	be	VB
cord-260476-whfyczcj	270	13	targeted	target	VBN
cord-260476-whfyczcj	270	14	by	by	IN
cord-260476-whfyczcj	270	15	HIV	HIV	NNP
cord-260476-whfyczcj	270	16	through	through	IN
cord-260476-whfyczcj	270	17	the	the	DT
cord-260476-whfyczcj	270	18	UPS	up	NNS
cord-260476-whfyczcj	270	19	.	.	.
cord-260476-whfyczcj	271	1	The	the	DT
cord-260476-whfyczcj	271	2	viral	viral	JJ
cord-260476-whfyczcj	271	3	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	271	4	protein	protein	NN
cord-260476-whfyczcj	271	5	Vpu	Vpu	NNP
cord-260476-whfyczcj	271	6	for	for	IN
cord-260476-whfyczcj	271	7	example	example	NN
cord-260476-whfyczcj	271	8	possesses	possess	VBZ
cord-260476-whfyczcj	271	9	the	the	DT
cord-260476-whfyczcj	271	10	ability	ability	NN
cord-260476-whfyczcj	271	11	to	to	TO
cord-260476-whfyczcj	271	12	associate	associate	VB
cord-260476-whfyczcj	271	13	with	with	IN
cord-260476-whfyczcj	271	14	the	the	DT
cord-260476-whfyczcj	271	15	CUL1-Skp1	CUL1-Skp1	NNP
cord-260476-whfyczcj	271	16	E3	e3	NN
cord-260476-whfyczcj	271	17	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	271	18	ligase	ligase	NN
cord-260476-whfyczcj	271	19	through	through	IN
cord-260476-whfyczcj	271	20	interaction	interaction	NN
cord-260476-whfyczcj	271	21	with	with	IN
cord-260476-whfyczcj	271	22	its	-PRON-	PRP$
cord-260476-whfyczcj	271	23	substrate	substrate	NN
cord-260476-whfyczcj	271	24	receptor	receptor	NN
cord-260476-whfyczcj	271	25	β	β	NN
cord-260476-whfyczcj	271	26	-	-	HYPH
cord-260476-whfyczcj	271	27	TrCP	TrCP	NNP
cord-260476-whfyczcj	271	28	.	.	.
cord-260476-whfyczcj	272	1	This	this	DT
cord-260476-whfyczcj	272	2	association	association	NN
cord-260476-whfyczcj	272	3	not	not	RB
cord-260476-whfyczcj	272	4	only	only	RB
cord-260476-whfyczcj	272	5	seems	seem	VBZ
cord-260476-whfyczcj	272	6	to	to	TO
cord-260476-whfyczcj	272	7	play	play	VB
cord-260476-whfyczcj	272	8	a	a	DT
cord-260476-whfyczcj	272	9	role	role	NN
cord-260476-whfyczcj	272	10	in	in	IN
cord-260476-whfyczcj	272	11	the	the	DT
cord-260476-whfyczcj	272	12	counteraction	counteraction	NN
cord-260476-whfyczcj	272	13	of	of	IN
cord-260476-whfyczcj	272	14	BST-2	BST-2	NNP
cord-260476-whfyczcj	272	15	but	but	CC
cord-260476-whfyczcj	272	16	has	have	VBZ
cord-260476-whfyczcj	272	17	also	also	RB
cord-260476-whfyczcj	272	18	been	be	VBN
cord-260476-whfyczcj	272	19	shown	show	VBN
cord-260476-whfyczcj	272	20	to	to	TO
cord-260476-whfyczcj	272	21	induce	induce	VB
cord-260476-whfyczcj	272	22	degradation	degradation	NN
cord-260476-whfyczcj	272	23	of	of	IN
cord-260476-whfyczcj	272	24	the	the	DT
cord-260476-whfyczcj	272	25	HIV	HIV	NNP
cord-260476-whfyczcj	272	26	receptor	receptor	NN
cord-260476-whfyczcj	272	27	CD4	CD4	NNP
cord-260476-whfyczcj	272	28	.	.	.
cord-260476-whfyczcj	273	1	Indeed	indeed	RB
cord-260476-whfyczcj	273	2	,	,	,
cord-260476-whfyczcj	273	3	Vpu	Vpu	NNP
cord-260476-whfyczcj	273	4	induces	induce	VBZ
cord-260476-whfyczcj	273	5	CD4	CD4	NNP
cord-260476-whfyczcj	273	6	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	273	7	followed	follow	VBN
cord-260476-whfyczcj	273	8	by	by	IN
cord-260476-whfyczcj	273	9	its	-PRON-	PRP$
cord-260476-whfyczcj	273	10	extraction	extraction	NN
cord-260476-whfyczcj	273	11	from	from	IN
cord-260476-whfyczcj	273	12	the	the	DT
cord-260476-whfyczcj	273	13	Endoplasmic	Endoplasmic	NNP
cord-260476-whfyczcj	273	14	Reticulum	Reticulum	NNP
cord-260476-whfyczcj	273	15	(	(	-LRB-
cord-260476-whfyczcj	273	16	ER	ER	NNP
cord-260476-whfyczcj	273	17	)	)	-RRB-
cord-260476-whfyczcj	273	18	[	[	-LRB-
cord-260476-whfyczcj	273	19	140	140	CD
cord-260476-whfyczcj	273	20	,	,	,
cord-260476-whfyczcj	273	21	[	[	-LRB-
cord-260476-whfyczcj	273	22	158	158	CD
cord-260476-whfyczcj	273	23	]	]	-RRB-
cord-260476-whfyczcj	273	24	[	[	-LRB-
cord-260476-whfyczcj	273	25	159	159	CD
cord-260476-whfyczcj	273	26	]	]	-RRB-
cord-260476-whfyczcj	273	27	[	[	-LRB-
cord-260476-whfyczcj	273	28	160	160	CD
cord-260476-whfyczcj	273	29	]	]	-RRB-
cord-260476-whfyczcj	273	30	[	[	-LRB-
cord-260476-whfyczcj	273	31	161	161	CD
cord-260476-whfyczcj	273	32	]	]	-RRB-
cord-260476-whfyczcj	273	33	[	[	-LRB-
cord-260476-whfyczcj	273	34	162	162	CD
cord-260476-whfyczcj	273	35	]	]	-RRB-
cord-260476-whfyczcj	273	36	.	.	.
cord-260476-whfyczcj	274	1	The	the	DT
cord-260476-whfyczcj	274	2	mechanism	mechanism	NN
cord-260476-whfyczcj	274	3	used	use	VBN
cord-260476-whfyczcj	274	4	by	by	IN
cord-260476-whfyczcj	274	5	Vpu	Vpu	NNP
cord-260476-whfyczcj	274	6	to	to	TO
cord-260476-whfyczcj	274	7	induce	induce	VB
cord-260476-whfyczcj	274	8	CD4	CD4	NNP
cord-260476-whfyczcj	274	9	depletion	depletion	NN
cord-260476-whfyczcj	274	10	involves	involve	VBZ
cord-260476-whfyczcj	274	11	the	the	DT
cord-260476-whfyczcj	274	12	cellular	cellular	JJ
cord-260476-whfyczcj	274	13	ER	er	NN
cord-260476-whfyczcj	274	14	-	-	HYPH
cord-260476-whfyczcj	274	15	associated	associate	VBN
cord-260476-whfyczcj	274	16	degradation	degradation	NN
cord-260476-whfyczcj	274	17	(	(	-LRB-
cord-260476-whfyczcj	274	18	ERAD	ERAD	NNP
cord-260476-whfyczcj	274	19	)	)	-RRB-
cord-260476-whfyczcj	274	20	pathway	pathway	NN
cord-260476-whfyczcj	274	21	,	,	,
cord-260476-whfyczcj	274	22	which	which	WDT
cord-260476-whfyczcj	274	23	operates	operate	VBZ
cord-260476-whfyczcj	274	24	as	as	IN
cord-260476-whfyczcj	274	25	a	a	DT
cord-260476-whfyczcj	274	26	quality	quality	NN
cord-260476-whfyczcj	274	27	control	control	NN
cord-260476-whfyczcj	274	28	mechanism	mechanism	NN
cord-260476-whfyczcj	274	29	to	to	TO
cord-260476-whfyczcj	274	30	dispose	dispose	VB
cord-260476-whfyczcj	274	31	of	of	IN
cord-260476-whfyczcj	274	32	unwanted	unwanted	JJ
cord-260476-whfyczcj	274	33	ER	er	NN
cord-260476-whfyczcj	274	34	membrane	membrane	NN
cord-260476-whfyczcj	274	35	proteins	protein	NNS
cord-260476-whfyczcj	274	36	into	into	IN
cord-260476-whfyczcj	274	37	the	the	DT
cord-260476-whfyczcj	274	38	cytosol	cytosol	NN
cord-260476-whfyczcj	274	39	for	for	IN
cord-260476-whfyczcj	274	40	subsequent	subsequent	JJ
cord-260476-whfyczcj	274	41	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	274	42	degradation	degradation	NN
cord-260476-whfyczcj	274	43	.	.	.
cord-260476-whfyczcj	275	1	The	the	DT
cord-260476-whfyczcj	275	2	dislocation	dislocation	NN
cord-260476-whfyczcj	275	3	of	of	IN
cord-260476-whfyczcj	275	4	protein	protein	NN
cord-260476-whfyczcj	275	5	from	from	IN
cord-260476-whfyczcj	275	6	the	the	DT
cord-260476-whfyczcj	275	7	membrane	membrane	NN
cord-260476-whfyczcj	275	8	is	be	VBZ
cord-260476-whfyczcj	275	9	achieved	achieve	VBN
cord-260476-whfyczcj	275	10	by	by	IN
cord-260476-whfyczcj	275	11	the	the	DT
cord-260476-whfyczcj	275	12	recruitment	recruitment	NN
cord-260476-whfyczcj	275	13	of	of	IN
cord-260476-whfyczcj	275	14	the	the	DT
cord-260476-whfyczcj	275	15	VCP	VCP	NNP
cord-260476-whfyczcj	275	16	-	-	HYPH
cord-260476-whfyczcj	275	17	UFD1L	UFD1L	NNP
cord-260476-whfyczcj	275	18	-	-	HYPH
cord-260476-whfyczcj	275	19	NPL4	NPL4	NNP
cord-260476-whfyczcj	275	20	(	(	-LRB-
cord-260476-whfyczcj	275	21	Valosin	Valosin	NNP
cord-260476-whfyczcj	275	22	-	-	HYPH
cord-260476-whfyczcj	275	23	containing	contain	VBG
cord-260476-whfyczcj	275	24	protein	protein	NN
cord-260476-whfyczcj	275	25	-Ubiquitin	-Ubiquitin	NNP
cord-260476-whfyczcj	275	26	fusion	fusion	NN
cord-260476-whfyczcj	275	27	degradation	degradation	NN
cord-260476-whfyczcj	275	28	protein	protein	NN
cord-260476-whfyczcj	275	29	1-Nuclear	1-nuclear	CD
cord-260476-whfyczcj	275	30	protein	protein	NN
cord-260476-whfyczcj	275	31	localization	localization	NN
cord-260476-whfyczcj	275	32	protein	protein	NN
cord-260476-whfyczcj	275	33	4	4	CD
cord-260476-whfyczcj	275	34	)	)	-RRB-
cord-260476-whfyczcj	275	35	complex	complex	JJ
cord-260476-whfyczcj	275	36	through	through	IN
cord-260476-whfyczcj	275	37	recognition	recognition	NN
cord-260476-whfyczcj	275	38	by	by	IN
cord-260476-whfyczcj	275	39	UFD1L	ufd1l	CD
cord-260476-whfyczcj	275	40	of	of	IN
cord-260476-whfyczcj	275	41	K48-linked	K48-linked	NNP
cord-260476-whfyczcj	275	42	poly	poly	JJ
cord-260476-whfyczcj	275	43	-	-	HYPH
cord-260476-whfyczcj	275	44	ubiquitin	ubiquitin	JJ
cord-260476-whfyczcj	275	45	chains	chain	NNS
cord-260476-whfyczcj	275	46	on	on	IN
cord-260476-whfyczcj	275	47	the	the	DT
cord-260476-whfyczcj	275	48	CD4	CD4	NNP
cord-260476-whfyczcj	275	49	cytosolic	cytosolic	JJ
cord-260476-whfyczcj	275	50	tail	tail	NN
cord-260476-whfyczcj	275	51	.	.	.
cord-260476-whfyczcj	276	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	276	2	,	,	,
cord-260476-whfyczcj	276	3	the	the	DT
cord-260476-whfyczcj	276	4	degradation	degradation	NN
cord-260476-whfyczcj	276	5	of	of	IN
cord-260476-whfyczcj	276	6	CD4	CD4	NNP
cord-260476-whfyczcj	276	7	depends	depend	VBZ
cord-260476-whfyczcj	276	8	also	also	RB
cord-260476-whfyczcj	276	9	on	on	IN
cord-260476-whfyczcj	276	10	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	276	11	of	of	IN
cord-260476-whfyczcj	276	12	serine	serine	NN
cord-260476-whfyczcj	276	13	/	/	SYM
cord-260476-whfyczcj	276	14	threonine	threonine	NN
cord-260476-whfyczcj	276	15	residues	residue	NNS
cord-260476-whfyczcj	276	16	[	[	-LRB-
cord-260476-whfyczcj	276	17	140	140	CD
cord-260476-whfyczcj	276	18	,	,	,
cord-260476-whfyczcj	276	19	[	[	-LRB-
cord-260476-whfyczcj	276	20	158	158	CD
cord-260476-whfyczcj	276	21	]	]	-RRB-
cord-260476-whfyczcj	276	22	[	[	-LRB-
cord-260476-whfyczcj	276	23	159	159	CD
cord-260476-whfyczcj	276	24	]	]	-RRB-
cord-260476-whfyczcj	276	25	[	[	-LRB-
cord-260476-whfyczcj	276	26	160	160	CD
cord-260476-whfyczcj	276	27	]	]	-RRB-
cord-260476-whfyczcj	276	28	[	[	-LRB-
cord-260476-whfyczcj	276	29	161	161	CD
cord-260476-whfyczcj	276	30	]	]	-RRB-
cord-260476-whfyczcj	276	31	.	.	.
cord-260476-whfyczcj	277	1	The	the	DT
cord-260476-whfyczcj	277	2	ATPase	ATPase	NNP
cord-260476-whfyczcj	277	3	activity	activity	NN
cord-260476-whfyczcj	277	4	of	of	IN
cord-260476-whfyczcj	277	5	VCP	VCP	NNP
cord-260476-whfyczcj	277	6	then	then	RB
cord-260476-whfyczcj	277	7	drives	drive	VBZ
cord-260476-whfyczcj	277	8	dislocation	dislocation	NN
cord-260476-whfyczcj	277	9	of	of	IN
cord-260476-whfyczcj	277	10	CD4	CD4	NNP
cord-260476-whfyczcj	277	11	from	from	IN
cord-260476-whfyczcj	277	12	the	the	DT
cord-260476-whfyczcj	277	13	ER	ER	NNP
cord-260476-whfyczcj	277	14	membrane	membrane	NN
cord-260476-whfyczcj	277	15	into	into	IN
cord-260476-whfyczcj	277	16	the	the	DT
cord-260476-whfyczcj	277	17	cytosol	cytosol	NN
cord-260476-whfyczcj	277	18	and	and	CC
cord-260476-whfyczcj	277	19	eventually	eventually	RB
cord-260476-whfyczcj	277	20	its	-PRON-	PRP$
cord-260476-whfyczcj	277	21	degradation	degradation	NN
cord-260476-whfyczcj	277	22	in	in	IN
cord-260476-whfyczcj	277	23	proteasomes	proteasomes	NNP
cord-260476-whfyczcj	277	24	.	.	.
cord-260476-whfyczcj	278	1	The	the	DT
cord-260476-whfyczcj	278	2	multiple	multiple	JJ
cord-260476-whfyczcj	278	3	levels	level	NNS
cord-260476-whfyczcj	278	4	at	at	IN
cord-260476-whfyczcj	278	5	which	which	WDT
cord-260476-whfyczcj	278	6	Vpu	Vpu	NNP
cord-260476-whfyczcj	278	7	acts	act	VBZ
cord-260476-whfyczcj	278	8	to	to	TO
cord-260476-whfyczcj	278	9	prevent	prevent	VB
cord-260476-whfyczcj	278	10	export	export	NN
cord-260476-whfyczcj	278	11	 	 	_SP
cord-260476-whfyczcj	279	1	The	the	DT
cord-260476-whfyczcj	279	2	UPS	UPS	NNP
cord-260476-whfyczcj	279	3	is	be	VBZ
cord-260476-whfyczcj	279	4	hijacked	hijack	VBN
cord-260476-whfyczcj	279	5	by	by	IN
cord-260476-whfyczcj	279	6	HIV	HIV	NNP
cord-260476-whfyczcj	279	7	and	and	CC
cord-260476-whfyczcj	279	8	plays	play	VBZ
cord-260476-whfyczcj	279	9	an	an	DT
cord-260476-whfyczcj	279	10	important	important	JJ
cord-260476-whfyczcj	279	11	role	role	NN
cord-260476-whfyczcj	279	12	for	for	IN
cord-260476-whfyczcj	279	13	the	the	DT
cord-260476-whfyczcj	279	14	viral	viral	JJ
cord-260476-whfyczcj	279	15	defense	defense	NN
cord-260476-whfyczcj	279	16	against	against	IN
cord-260476-whfyczcj	279	17	multiple	multiple	JJ
cord-260476-whfyczcj	279	18	cellular	cellular	JJ
cord-260476-whfyczcj	279	19	restriction	restriction	NN
cord-260476-whfyczcj	279	20	mechanisms	mechanism	NNS
cord-260476-whfyczcj	279	21	.	.	.
cord-260476-whfyczcj	280	1	Apart	apart	RB
cord-260476-whfyczcj	280	2	from	from	IN
cord-260476-whfyczcj	280	3	restriction	restriction	NN
cord-260476-whfyczcj	280	4	factors	factor	NNS
cord-260476-whfyczcj	280	5	,	,	,
cord-260476-whfyczcj	280	6	several	several	JJ
cord-260476-whfyczcj	280	7	other	other	JJ
cord-260476-whfyczcj	280	8	cellular	cellular	JJ
cord-260476-whfyczcj	280	9	proteins	protein	NNS
cord-260476-whfyczcj	280	10	can	can	MD
cord-260476-whfyczcj	280	11	also	also	RB
cord-260476-whfyczcj	280	12	be	be	VB
cord-260476-whfyczcj	280	13	targeted	target	VBN
cord-260476-whfyczcj	280	14	by	by	IN
cord-260476-whfyczcj	280	15	HIV	HIV	NNP
cord-260476-whfyczcj	280	16	through	through	IN
cord-260476-whfyczcj	280	17	the	the	DT
cord-260476-whfyczcj	280	18	UPS	up	NNS
cord-260476-whfyczcj	280	19	.	.	.
cord-260476-whfyczcj	281	1	The	the	DT
cord-260476-whfyczcj	281	2	viral	viral	JJ
cord-260476-whfyczcj	281	3	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	281	4	protein	protein	NN
cord-260476-whfyczcj	281	5	Vpu	Vpu	NNP
cord-260476-whfyczcj	281	6	for	for	IN
cord-260476-whfyczcj	281	7	example	example	NN
cord-260476-whfyczcj	281	8	possesses	possess	VBZ
cord-260476-whfyczcj	281	9	the	the	DT
cord-260476-whfyczcj	281	10	ability	ability	NN
cord-260476-whfyczcj	281	11	to	to	TO
cord-260476-whfyczcj	281	12	associate	associate	VB
cord-260476-whfyczcj	281	13	with	with	IN
cord-260476-whfyczcj	281	14	the	the	DT
cord-260476-whfyczcj	281	15	CUL1-Skp1	CUL1-Skp1	NNP
cord-260476-whfyczcj	281	16	E3	e3	NN
cord-260476-whfyczcj	281	17	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	281	18	ligase	ligase	NN
cord-260476-whfyczcj	281	19	through	through	IN
cord-260476-whfyczcj	281	20	interaction	interaction	NN
cord-260476-whfyczcj	281	21	with	with	IN
cord-260476-whfyczcj	281	22	its	-PRON-	PRP$
cord-260476-whfyczcj	281	23	substrate	substrate	NN
cord-260476-whfyczcj	281	24	receptor	receptor	NN
cord-260476-whfyczcj	281	25	β	β	NN
cord-260476-whfyczcj	281	26	-	-	HYPH
cord-260476-whfyczcj	281	27	TrCP	TrCP	NNP
cord-260476-whfyczcj	281	28	.	.	.
cord-260476-whfyczcj	282	1	This	this	DT
cord-260476-whfyczcj	282	2	association	association	NN
cord-260476-whfyczcj	282	3	not	not	RB
cord-260476-whfyczcj	282	4	only	only	RB
cord-260476-whfyczcj	282	5	seems	seem	VBZ
cord-260476-whfyczcj	282	6	to	to	TO
cord-260476-whfyczcj	282	7	play	play	VB
cord-260476-whfyczcj	282	8	a	a	DT
cord-260476-whfyczcj	282	9	role	role	NN
cord-260476-whfyczcj	282	10	in	in	IN
cord-260476-whfyczcj	282	11	the	the	DT
cord-260476-whfyczcj	282	12	counteraction	counteraction	NN
cord-260476-whfyczcj	282	13	of	of	IN
cord-260476-whfyczcj	282	14	BST-2	BST-2	NNP
cord-260476-whfyczcj	282	15	but	but	CC
cord-260476-whfyczcj	282	16	has	have	VBZ
cord-260476-whfyczcj	282	17	also	also	RB
cord-260476-whfyczcj	282	18	been	be	VBN
cord-260476-whfyczcj	282	19	shown	show	VBN
cord-260476-whfyczcj	282	20	to	to	TO
cord-260476-whfyczcj	282	21	induce	induce	VB
cord-260476-whfyczcj	282	22	degradation	degradation	NN
cord-260476-whfyczcj	282	23	of	of	IN
cord-260476-whfyczcj	282	24	the	the	DT
cord-260476-whfyczcj	282	25	HIV	HIV	NNP
cord-260476-whfyczcj	282	26	receptor	receptor	NN
cord-260476-whfyczcj	282	27	CD4	CD4	NNP
cord-260476-whfyczcj	282	28	.	.	.
cord-260476-whfyczcj	283	1	Indeed	indeed	RB
cord-260476-whfyczcj	283	2	,	,	,
cord-260476-whfyczcj	283	3	Vpu	Vpu	NNP
cord-260476-whfyczcj	283	4	induces	induce	VBZ
cord-260476-whfyczcj	283	5	CD4	CD4	NNP
cord-260476-whfyczcj	283	6	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	283	7	followed	follow	VBN
cord-260476-whfyczcj	283	8	by	by	IN
cord-260476-whfyczcj	283	9	its	-PRON-	PRP$
cord-260476-whfyczcj	283	10	extraction	extraction	NN
cord-260476-whfyczcj	283	11	from	from	IN
cord-260476-whfyczcj	283	12	the	the	DT
cord-260476-whfyczcj	283	13	Endoplasmic	Endoplasmic	NNP
cord-260476-whfyczcj	283	14	Reticulum	Reticulum	NNP
cord-260476-whfyczcj	283	15	(	(	-LRB-
cord-260476-whfyczcj	283	16	ER	ER	NNP
cord-260476-whfyczcj	283	17	)	)	-RRB-
cord-260476-whfyczcj	283	18	[	[	-LRB-
cord-260476-whfyczcj	283	19	140	140	CD
cord-260476-whfyczcj	283	20	,	,	,
cord-260476-whfyczcj	283	21	[	[	-LRB-
cord-260476-whfyczcj	283	22	158	158	CD
cord-260476-whfyczcj	283	23	]	]	-RRB-
cord-260476-whfyczcj	283	24	[	[	-LRB-
cord-260476-whfyczcj	283	25	159	159	CD
cord-260476-whfyczcj	283	26	]	]	-RRB-
cord-260476-whfyczcj	283	27	[	[	-LRB-
cord-260476-whfyczcj	283	28	160	160	CD
cord-260476-whfyczcj	283	29	]	]	-RRB-
cord-260476-whfyczcj	283	30	[	[	-LRB-
cord-260476-whfyczcj	283	31	161	161	CD
cord-260476-whfyczcj	283	32	]	]	-RRB-
cord-260476-whfyczcj	283	33	[	[	-LRB-
cord-260476-whfyczcj	283	34	162	162	CD
cord-260476-whfyczcj	283	35	]	]	-RRB-
cord-260476-whfyczcj	283	36	.	.	.
cord-260476-whfyczcj	284	1	The	the	DT
cord-260476-whfyczcj	284	2	mechanism	mechanism	NN
cord-260476-whfyczcj	284	3	used	use	VBN
cord-260476-whfyczcj	284	4	by	by	IN
cord-260476-whfyczcj	284	5	Vpu	Vpu	NNP
cord-260476-whfyczcj	284	6	to	to	TO
cord-260476-whfyczcj	284	7	induce	induce	VB
cord-260476-whfyczcj	284	8	CD4	CD4	NNP
cord-260476-whfyczcj	284	9	depletion	depletion	NN
cord-260476-whfyczcj	284	10	involves	involve	VBZ
cord-260476-whfyczcj	284	11	the	the	DT
cord-260476-whfyczcj	284	12	cellular	cellular	JJ
cord-260476-whfyczcj	284	13	ER	er	NN
cord-260476-whfyczcj	284	14	-	-	HYPH
cord-260476-whfyczcj	284	15	associated	associate	VBN
cord-260476-whfyczcj	284	16	degradation	degradation	NN
cord-260476-whfyczcj	284	17	(	(	-LRB-
cord-260476-whfyczcj	284	18	ERAD	ERAD	NNP
cord-260476-whfyczcj	284	19	)	)	-RRB-
cord-260476-whfyczcj	284	20	pathway	pathway	NN
cord-260476-whfyczcj	284	21	,	,	,
cord-260476-whfyczcj	284	22	which	which	WDT
cord-260476-whfyczcj	284	23	operates	operate	VBZ
cord-260476-whfyczcj	284	24	as	as	IN
cord-260476-whfyczcj	284	25	a	a	DT
cord-260476-whfyczcj	284	26	quality	quality	NN
cord-260476-whfyczcj	284	27	control	control	NN
cord-260476-whfyczcj	284	28	mechanism	mechanism	NN
cord-260476-whfyczcj	284	29	to	to	TO
cord-260476-whfyczcj	284	30	dispose	dispose	VB
cord-260476-whfyczcj	284	31	of	of	IN
cord-260476-whfyczcj	284	32	unwanted	unwanted	JJ
cord-260476-whfyczcj	284	33	ER	er	NN
cord-260476-whfyczcj	284	34	membrane	membrane	NN
cord-260476-whfyczcj	284	35	proteins	protein	NNS
cord-260476-whfyczcj	284	36	into	into	IN
cord-260476-whfyczcj	284	37	the	the	DT
cord-260476-whfyczcj	284	38	cytosol	cytosol	NN
cord-260476-whfyczcj	284	39	for	for	IN
cord-260476-whfyczcj	284	40	subsequent	subsequent	JJ
cord-260476-whfyczcj	284	41	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	284	42	degradation	degradation	NN
cord-260476-whfyczcj	284	43	.	.	.
cord-260476-whfyczcj	285	1	The	the	DT
cord-260476-whfyczcj	285	2	dislocation	dislocation	NN
cord-260476-whfyczcj	285	3	of	of	IN
cord-260476-whfyczcj	285	4	protein	protein	NN
cord-260476-whfyczcj	285	5	from	from	IN
cord-260476-whfyczcj	285	6	the	the	DT
cord-260476-whfyczcj	285	7	membrane	membrane	NN
cord-260476-whfyczcj	285	8	is	be	VBZ
cord-260476-whfyczcj	285	9	achieved	achieve	VBN
cord-260476-whfyczcj	285	10	by	by	IN
cord-260476-whfyczcj	285	11	the	the	DT
cord-260476-whfyczcj	285	12	recruitment	recruitment	NN
cord-260476-whfyczcj	285	13	of	of	IN
cord-260476-whfyczcj	285	14	the	the	DT
cord-260476-whfyczcj	285	15	VCP	VCP	NNP
cord-260476-whfyczcj	285	16	-	-	HYPH
cord-260476-whfyczcj	285	17	UFD1L	UFD1L	NNP
cord-260476-whfyczcj	285	18	-	-	HYPH
cord-260476-whfyczcj	285	19	NPL4	NPL4	NNP
cord-260476-whfyczcj	285	20	(	(	-LRB-
cord-260476-whfyczcj	285	21	Valosin	Valosin	NNP
cord-260476-whfyczcj	285	22	-	-	HYPH
cord-260476-whfyczcj	285	23	containing	contain	VBG
cord-260476-whfyczcj	285	24	protein	protein	NN
cord-260476-whfyczcj	285	25	-	-	HYPH
cord-260476-whfyczcj	285	26	Ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	285	27	fusion	fusion	NN
cord-260476-whfyczcj	285	28	degradation	degradation	NN
cord-260476-whfyczcj	285	29	protein	protein	NN
cord-260476-whfyczcj	285	30	1-Nuclear	1-nuclear	CD
cord-260476-whfyczcj	285	31	protein	protein	NN
cord-260476-whfyczcj	285	32	localization	localization	NN
cord-260476-whfyczcj	285	33	protein	protein	NN
cord-260476-whfyczcj	285	34	4	4	CD
cord-260476-whfyczcj	285	35	)	)	-RRB-
cord-260476-whfyczcj	285	36	complex	complex	JJ
cord-260476-whfyczcj	285	37	through	through	IN
cord-260476-whfyczcj	285	38	recognition	recognition	NN
cord-260476-whfyczcj	285	39	by	by	IN
cord-260476-whfyczcj	285	40	UFD1L	ufd1l	CD
cord-260476-whfyczcj	285	41	of	of	IN
cord-260476-whfyczcj	285	42	K48-linked	K48-linked	NNP
cord-260476-whfyczcj	285	43	poly	poly	JJ
cord-260476-whfyczcj	285	44	-	-	HYPH
cord-260476-whfyczcj	285	45	ubiquitin	ubiquitin	JJ
cord-260476-whfyczcj	285	46	chains	chain	NNS
cord-260476-whfyczcj	285	47	on	on	IN
cord-260476-whfyczcj	285	48	the	the	DT
cord-260476-whfyczcj	285	49	CD4	CD4	NNP
cord-260476-whfyczcj	285	50	cytosolic	cytosolic	JJ
cord-260476-whfyczcj	285	51	tail	tail	NN
cord-260476-whfyczcj	285	52	.	.	.
cord-260476-whfyczcj	286	1	Interestingly	interestingly	RB
cord-260476-whfyczcj	286	2	,	,	,
cord-260476-whfyczcj	286	3	the	the	DT
cord-260476-whfyczcj	286	4	degradation	degradation	NN
cord-260476-whfyczcj	286	5	of	of	IN
cord-260476-whfyczcj	286	6	CD4	CD4	NNP
cord-260476-whfyczcj	286	7	depends	depend	VBZ
cord-260476-whfyczcj	286	8	also	also	RB
cord-260476-whfyczcj	286	9	on	on	IN
cord-260476-whfyczcj	286	10	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	286	11	of	of	IN
cord-260476-whfyczcj	286	12	serine	serine	NN
cord-260476-whfyczcj	286	13	/	/	SYM
cord-260476-whfyczcj	286	14	threonine	threonine	NN
cord-260476-whfyczcj	286	15	residues	residue	NNS
cord-260476-whfyczcj	286	16	[	[	-LRB-
cord-260476-whfyczcj	286	17	140	140	CD
cord-260476-whfyczcj	286	18	,	,	,
cord-260476-whfyczcj	286	19	[	[	-LRB-
cord-260476-whfyczcj	286	20	158	158	CD
cord-260476-whfyczcj	286	21	]	]	-RRB-
cord-260476-whfyczcj	286	22	[	[	-LRB-
cord-260476-whfyczcj	286	23	159	159	CD
cord-260476-whfyczcj	286	24	]	]	-RRB-
cord-260476-whfyczcj	286	25	[	[	-LRB-
cord-260476-whfyczcj	286	26	160	160	CD
cord-260476-whfyczcj	286	27	]	]	-RRB-
cord-260476-whfyczcj	286	28	[	[	-LRB-
cord-260476-whfyczcj	286	29	161	161	CD
cord-260476-whfyczcj	286	30	]	]	-RRB-
cord-260476-whfyczcj	286	31	.	.	.
cord-260476-whfyczcj	287	1	The	the	DT
cord-260476-whfyczcj	287	2	ATPase	ATPase	NNP
cord-260476-whfyczcj	287	3	activity	activity	NN
cord-260476-whfyczcj	287	4	of	of	IN
cord-260476-whfyczcj	287	5	VCP	VCP	NNP
cord-260476-whfyczcj	287	6	then	then	RB
cord-260476-whfyczcj	287	7	drives	drive	VBZ
cord-260476-whfyczcj	287	8	dislocation	dislocation	NN
cord-260476-whfyczcj	287	9	of	of	IN
cord-260476-whfyczcj	287	10	CD4	CD4	NNP
cord-260476-whfyczcj	287	11	from	from	IN
cord-260476-whfyczcj	287	12	the	the	DT
cord-260476-whfyczcj	287	13	ER	ER	NNP
cord-260476-whfyczcj	287	14	membrane	membrane	NN
cord-260476-whfyczcj	287	15	into	into	IN
cord-260476-whfyczcj	287	16	the	the	DT
cord-260476-whfyczcj	287	17	cytosol	cytosol	NN
cord-260476-whfyczcj	287	18	and	and	CC
cord-260476-whfyczcj	287	19	eventually	eventually	RB
cord-260476-whfyczcj	287	20	its	-PRON-	PRP$
cord-260476-whfyczcj	287	21	degradation	degradation	NN
cord-260476-whfyczcj	287	22	in	in	IN
cord-260476-whfyczcj	287	23	proteasomes	proteasomes	NNP
cord-260476-whfyczcj	287	24	.	.	.
cord-260476-whfyczcj	288	1	The	the	DT
cord-260476-whfyczcj	288	2	multiple	multiple	JJ
cord-260476-whfyczcj	288	3	levels	level	NNS
cord-260476-whfyczcj	288	4	at	at	IN
cord-260476-whfyczcj	288	5	which	which	WDT
cord-260476-whfyczcj	288	6	Vpu	Vpu	NNP
cord-260476-whfyczcj	288	7	acts	act	VBZ
cord-260476-whfyczcj	288	8	to	to	TO
cord-260476-whfyczcj	288	9	prevent	prevent	VB
cord-260476-whfyczcj	288	10	export	export	NN
cord-260476-whfyczcj	288	11	of	of	IN
cord-260476-whfyczcj	288	12	CD4	CD4	NNP
cord-260476-whfyczcj	288	13	from	from	IN
cord-260476-whfyczcj	288	14	the	the	DT
cord-260476-whfyczcj	288	15	ER	ER	NNP
cord-260476-whfyczcj	288	16	underscore	underscore	VBP
cord-260476-whfyczcj	288	17	the	the	DT
cord-260476-whfyczcj	288	18	importance	importance	NN
cord-260476-whfyczcj	288	19	of	of	IN
cord-260476-whfyczcj	288	20	ensuring	ensure	VBG
cord-260476-whfyczcj	288	21	complete	complete	JJ
cord-260476-whfyczcj	288	22	depletion	depletion	NN
cord-260476-whfyczcj	288	23	of	of	IN
cord-260476-whfyczcj	288	24	CD4	CD4	NNP
cord-260476-whfyczcj	288	25	from	from	IN
cord-260476-whfyczcj	288	26	the	the	DT
cord-260476-whfyczcj	288	27	plasma	plasma	NN
cord-260476-whfyczcj	288	28	membrane	membrane	NN
cord-260476-whfyczcj	288	29	for	for	IN
cord-260476-whfyczcj	288	30	progression	progression	NN
cord-260476-whfyczcj	288	31	of	of	IN
cord-260476-whfyczcj	288	32	the	the	DT
cord-260476-whfyczcj	288	33	infection	infection	NN
cord-260476-whfyczcj	288	34	[	[	-LRB-
cord-260476-whfyczcj	288	35	143	143	CD
cord-260476-whfyczcj	288	36	,	,	,
cord-260476-whfyczcj	288	37	160	160	CD
cord-260476-whfyczcj	288	38	,	,	,
cord-260476-whfyczcj	288	39	161	161	CD
cord-260476-whfyczcj	288	40	,	,	,
cord-260476-whfyczcj	288	41	163	163	CD
cord-260476-whfyczcj	288	42	]	]	-RRB-
cord-260476-whfyczcj	288	43	.	.	.
cord-260476-whfyczcj	289	1	Other	other	JJ
cord-260476-whfyczcj	289	2	targets	target	NNS
cord-260476-whfyczcj	289	3	of	of	IN
cord-260476-whfyczcj	289	4	Vpu	Vpu	NNP
cord-260476-whfyczcj	289	5	-	-	HYPH
cord-260476-whfyczcj	289	6	induced	induce	VBN
cord-260476-whfyczcj	289	7	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	289	8	and	and	CC
cord-260476-whfyczcj	289	9	degradation	degradation	NN
cord-260476-whfyczcj	289	10	include	include	VBP
cord-260476-whfyczcj	289	11	the	the	DT
cord-260476-whfyczcj	289	12	cell	cell	NN
cord-260476-whfyczcj	289	13	surface	surface	NN
cord-260476-whfyczcj	289	14	glycoprotein	glycoprotein	NN
cord-260476-whfyczcj	289	15	ICAM-1	icam-1	NN
cord-260476-whfyczcj	289	16	and	and	CC
cord-260476-whfyczcj	289	17	the	the	DT
cord-260476-whfyczcj	289	18	amino	amino	NN
cord-260476-whfyczcj	289	19	acid	acid	NN
cord-260476-whfyczcj	289	20	transporter	transporter	NN
cord-260476-whfyczcj	289	21	SNAT-1	SNAT-1	NNP
cord-260476-whfyczcj	289	22	,	,	,
cord-260476-whfyczcj	289	23	both	both	DT
cord-260476-whfyczcj	289	24	involved	involve	VBN
cord-260476-whfyczcj	289	25	in	in	IN
cord-260476-whfyczcj	289	26	immune	immune	JJ
cord-260476-whfyczcj	289	27	signaling	signal	VBG
cord-260476-whfyczcj	289	28	[	[	-LRB-
cord-260476-whfyczcj	289	29	164	164	CD
cord-260476-whfyczcj	289	30	,	,	,
cord-260476-whfyczcj	289	31	165	165	CD
cord-260476-whfyczcj	289	32	]	]	-RRB-
cord-260476-whfyczcj	289	33	.	.	.
cord-260476-whfyczcj	290	1	It	-PRON-	PRP
cord-260476-whfyczcj	290	2	is	be	VBZ
cord-260476-whfyczcj	290	3	well	well	RB
cord-260476-whfyczcj	290	4	established	establish	VBN
cord-260476-whfyczcj	290	5	that	that	IN
cord-260476-whfyczcj	290	6	the	the	DT
cord-260476-whfyczcj	290	7	viral	viral	JJ
cord-260476-whfyczcj	290	8	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	290	9	protein	protein	NN
cord-260476-whfyczcj	290	10	Vpr	Vpr	NNP
cord-260476-whfyczcj	290	11	associates	associate	NNS
cord-260476-whfyczcj	290	12	with	with	IN
cord-260476-whfyczcj	290	13	the	the	DT
cord-260476-whfyczcj	290	14	CUL4A	cul4a	NN
cord-260476-whfyczcj	290	15	-	-	HYPH
cord-260476-whfyczcj	290	16	RING	ring	NN
cord-260476-whfyczcj	290	17	E3	e3	NN
cord-260476-whfyczcj	290	18	ligase	ligase	NN
cord-260476-whfyczcj	290	19	through	through	IN
cord-260476-whfyczcj	290	20	interaction	interaction	NN
cord-260476-whfyczcj	290	21	with	with	IN
cord-260476-whfyczcj	290	22	its	-PRON-	PRP$
cord-260476-whfyczcj	290	23	substrate	substrate	NN
cord-260476-whfyczcj	290	24	recognition	recognition	NN
cord-260476-whfyczcj	290	25	subunit	subunit	NN
cord-260476-whfyczcj	290	26	DCAF1	dcaf1	NN
cord-260476-whfyczcj	290	27	.	.	.
cord-260476-whfyczcj	291	1	This	this	DT
cord-260476-whfyczcj	291	2	complex	complex	NN
cord-260476-whfyczcj	291	3	has	have	VBZ
cord-260476-whfyczcj	291	4	been	be	VBN
cord-260476-whfyczcj	291	5	shown	show	VBN
cord-260476-whfyczcj	291	6	to	to	TO
cord-260476-whfyczcj	291	7	induce	induce	VB
cord-260476-whfyczcj	291	8	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	291	9	followed	follow	VBN
cord-260476-whfyczcj	291	10	by	by	IN
cord-260476-whfyczcj	291	11	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	291	12	degradation	degradation	NN
cord-260476-whfyczcj	291	13	of	of	IN
cord-260476-whfyczcj	291	14	the	the	DT
cord-260476-whfyczcj	291	15	DNA	dna	NN
cord-260476-whfyczcj	291	16	glycosylase	glycosylase	NN
cord-260476-whfyczcj	291	17	UNG2	UNG2	NNP
cord-260476-whfyczcj	291	18	.	.	.
cord-260476-whfyczcj	292	1	Thereby	thereby	RB
cord-260476-whfyczcj	292	2	Vpr	Vpr	NNP
cord-260476-whfyczcj	292	3	reduces	reduce	VBZ
cord-260476-whfyczcj	292	4	encapsidation	encapsidation	NN
cord-260476-whfyczcj	292	5	of	of	IN
cord-260476-whfyczcj	292	6	UNG2	UNG2	NNP
cord-260476-whfyczcj	292	7	,	,	,
cord-260476-whfyczcj	292	8	ultimately	ultimately	RB
cord-260476-whfyczcj	292	9	contributing	contribute	VBG
cord-260476-whfyczcj	292	10	to	to	IN
cord-260476-whfyczcj	292	11	the	the	DT
cord-260476-whfyczcj	292	12	protection	protection	NN
cord-260476-whfyczcj	292	13	against	against	IN
cord-260476-whfyczcj	292	14	the	the	DT
cord-260476-whfyczcj	292	15	restriction	restriction	NN
cord-260476-whfyczcj	292	16	factor	factor	NN
cord-260476-whfyczcj	292	17	A3G.	A3G.	NNP
cord-260476-whfyczcj	292	18	UNG2	UNG2	NNP
cord-260476-whfyczcj	292	19	recognizes	recognize	VBZ
cord-260476-whfyczcj	292	20	C	c	NN
cord-260476-whfyczcj	292	21	to	to	IN
cord-260476-whfyczcj	292	22	U	u	NN
cord-260476-whfyczcj	292	23	mutations	mutation	NNS
cord-260476-whfyczcj	292	24	induced	induce	VBN
cord-260476-whfyczcj	292	25	by	by	IN
cord-260476-whfyczcj	292	26	A3	A3	NNP
cord-260476-whfyczcj	292	27	G	G	NNP
cord-260476-whfyczcj	292	28	and	and	CC
cord-260476-whfyczcj	292	29	generates	generate	VBZ
cord-260476-whfyczcj	292	30	abasic	abasic	NN
cord-260476-whfyczcj	292	31	sites	site	NNS
cord-260476-whfyczcj	292	32	,	,	,
cord-260476-whfyczcj	292	33	leading	lead	VBG
cord-260476-whfyczcj	292	34	to	to	IN
cord-260476-whfyczcj	292	35	degradation	degradation	NN
cord-260476-whfyczcj	292	36	of	of	IN
cord-260476-whfyczcj	292	37	viral	viral	JJ
cord-260476-whfyczcj	292	38	DNA	dna	NN
cord-260476-whfyczcj	292	39	.	.	.
cord-260476-whfyczcj	293	1	Indeed	indeed	RB
cord-260476-whfyczcj	293	2	a	a	DT
cord-260476-whfyczcj	293	3	virus	virus	NN
cord-260476-whfyczcj	293	4	lacking	lack	VBG
cord-260476-whfyczcj	293	5	Vif	vif	NN
cord-260476-whfyczcj	293	6	can	can	MD
cord-260476-whfyczcj	293	7	be	be	VB
cord-260476-whfyczcj	293	8	partially	partially	RB
cord-260476-whfyczcj	293	9	rescued	rescue	VBN
cord-260476-whfyczcj	293	10	by	by	IN
cord-260476-whfyczcj	293	11	Vpr	Vpr	NNP
cord-260476-whfyczcj	293	12	-	-	HYPH
cord-260476-whfyczcj	293	13	mediated	mediate	VBN
cord-260476-whfyczcj	293	14	reduction	reduction	NN
cord-260476-whfyczcj	293	15	of	of	IN
cord-260476-whfyczcj	293	16	UNG2	UNG2	NNP
cord-260476-whfyczcj	293	17	compared	compare	VBN
cord-260476-whfyczcj	293	18	to	to	IN
cord-260476-whfyczcj	293	19	viruses	virus	NNS
cord-260476-whfyczcj	293	20	lacking	lack	VBG
cord-260476-whfyczcj	293	21	both	both	CC
cord-260476-whfyczcj	293	22	Vif	Vif	NNP
cord-260476-whfyczcj	293	23	and	and	CC
cord-260476-whfyczcj	293	24	Vpr	Vpr	NNP
cord-260476-whfyczcj	293	25	[	[	-LRB-
cord-260476-whfyczcj	293	26	166	166	CD
cord-260476-whfyczcj	293	27	]	]	-RRB-
cord-260476-whfyczcj	293	28	[	[	-LRB-
cord-260476-whfyczcj	293	29	167	167	CD
cord-260476-whfyczcj	293	30	]	]	-RRB-
cord-260476-whfyczcj	293	31	[	[	-LRB-
cord-260476-whfyczcj	293	32	168	168	CD
cord-260476-whfyczcj	293	33	]	]	-RRB-
cord-260476-whfyczcj	293	34	.	.	.
cord-260476-whfyczcj	294	1	Moreover	moreover	RB
cord-260476-whfyczcj	294	2	,	,	,
cord-260476-whfyczcj	294	3	it	-PRON-	PRP
cord-260476-whfyczcj	294	4	has	have	VBZ
cord-260476-whfyczcj	294	5	recently	recently	RB
cord-260476-whfyczcj	294	6	been	be	VBN
cord-260476-whfyczcj	294	7	shown	show	VBN
cord-260476-whfyczcj	294	8	that	that	IN
cord-260476-whfyczcj	294	9	Vpr	Vpr	NNP
cord-260476-whfyczcj	294	10	can	can	MD
cord-260476-whfyczcj	294	11	also	also	RB
cord-260476-whfyczcj	294	12	induce	induce	VB
cord-260476-whfyczcj	294	13	the	the	DT
cord-260476-whfyczcj	294	14	degradation	degradation	NN
cord-260476-whfyczcj	294	15	of	of	IN
cord-260476-whfyczcj	294	16	A3	A3	NNP
cord-260476-whfyczcj	294	17	G	G	NNP
cord-260476-whfyczcj	294	18	itself	-PRON-	PRP
cord-260476-whfyczcj	294	19	through	through	IN
cord-260476-whfyczcj	294	20	the	the	DT
cord-260476-whfyczcj	294	21	UPS	up	NNS
cord-260476-whfyczcj	294	22	[	[	-LRB-
cord-260476-whfyczcj	294	23	169	169	CD
cord-260476-whfyczcj	294	24	]	]	-RRB-
cord-260476-whfyczcj	294	25	.	.	.
cord-260476-whfyczcj	295	1	Vpr	Vpr	NNP
cord-260476-whfyczcj	295	2	seems	seem	VBZ
cord-260476-whfyczcj	295	3	to	to	TO
cord-260476-whfyczcj	295	4	also	also	RB
cord-260476-whfyczcj	295	5	enhance	enhance	VB
cord-260476-whfyczcj	295	6	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	295	7	production	production	NN
cord-260476-whfyczcj	295	8	in	in	IN
cord-260476-whfyczcj	295	9	macrophages	macrophage	NNS
cord-260476-whfyczcj	295	10	by	by	IN
cord-260476-whfyczcj	295	11	UPS	UPS	NNP
cord-260476-whfyczcj	295	12	-	-	HYPH
cord-260476-whfyczcj	295	13	mediated	mediate	VBN
cord-260476-whfyczcj	295	14	degradation	degradation	NN
cord-260476-whfyczcj	295	15	of	of	IN
cord-260476-whfyczcj	295	16	the	the	DT
cord-260476-whfyczcj	295	17	cellular	cellular	JJ
cord-260476-whfyczcj	295	18	protein	protein	NN
cord-260476-whfyczcj	295	19	Dicer	Dicer	NNP
cord-260476-whfyczcj	295	20	,	,	,
cord-260476-whfyczcj	295	21	which	which	WDT
cord-260476-whfyczcj	295	22	is	be	VBZ
cord-260476-whfyczcj	295	23	involved	involve	VBN
cord-260476-whfyczcj	295	24	in	in	IN
cord-260476-whfyczcj	295	25	RNA	RNA	NNP
cord-260476-whfyczcj	295	26	silencing	silence	VBG
cord-260476-whfyczcj	295	27	[	[	-LRB-
cord-260476-whfyczcj	295	28	170	170	CD
cord-260476-whfyczcj	295	29	]	]	-RRB-
cord-260476-whfyczcj	295	30	.	.	.
cord-260476-whfyczcj	296	1	The	the	DT
cord-260476-whfyczcj	296	2	main	main	JJ
cord-260476-whfyczcj	296	3	function	function	NN
cord-260476-whfyczcj	296	4	of	of	IN
cord-260476-whfyczcj	296	5	Vpr	Vpr	NNP
cord-260476-whfyczcj	296	6	known	know	VBN
cord-260476-whfyczcj	296	7	to	to	IN
cord-260476-whfyczcj	296	8	date	date	NN
cord-260476-whfyczcj	296	9	is	be	VBZ
cord-260476-whfyczcj	296	10	the	the	DT
cord-260476-whfyczcj	296	11	induction	induction	NN
cord-260476-whfyczcj	296	12	of	of	IN
cord-260476-whfyczcj	296	13	a	a	DT
cord-260476-whfyczcj	296	14	cell	cell	NN
cord-260476-whfyczcj	296	15	cycle	cycle	NN
cord-260476-whfyczcj	296	16	arrest	arrest	NN
cord-260476-whfyczcj	296	17	at	at	IN
cord-260476-whfyczcj	296	18	the	the	DT
cord-260476-whfyczcj	296	19	G2	G2	NNP
cord-260476-whfyczcj	296	20	phase	phase	NN
cord-260476-whfyczcj	296	21	.	.	.
cord-260476-whfyczcj	297	1	The	the	DT
cord-260476-whfyczcj	297	2	association	association	NN
cord-260476-whfyczcj	297	3	of	of	IN
cord-260476-whfyczcj	297	4	Vpr	Vpr	NNP
cord-260476-whfyczcj	297	5	with	with	IN
cord-260476-whfyczcj	297	6	the	the	DT
cord-260476-whfyczcj	297	7	CUL4A	cul4a	NN
cord-260476-whfyczcj	297	8	E3	e3	NN
cord-260476-whfyczcj	297	9	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	297	10	ligase	ligase	NN
cord-260476-whfyczcj	297	11	has	have	VBZ
cord-260476-whfyczcj	297	12	been	be	VBN
cord-260476-whfyczcj	297	13	shown	show	VBN
cord-260476-whfyczcj	297	14	to	to	TO
cord-260476-whfyczcj	297	15	be	be	VB
cord-260476-whfyczcj	297	16	important	important	JJ
cord-260476-whfyczcj	297	17	for	for	IN
cord-260476-whfyczcj	297	18	this	this	DT
cord-260476-whfyczcj	297	19	process	process	NN
cord-260476-whfyczcj	297	20	,	,	,
cord-260476-whfyczcj	297	21	although	although	IN
cord-260476-whfyczcj	297	22	the	the	DT
cord-260476-whfyczcj	297	23	exact	exact	JJ
cord-260476-whfyczcj	297	24	mechanism	mechanism	NN
cord-260476-whfyczcj	297	25	is	be	VBZ
cord-260476-whfyczcj	297	26	still	still	RB
cord-260476-whfyczcj	297	27	unknown	unknown	JJ
cord-260476-whfyczcj	297	28	[	[	-LRB-
cord-260476-whfyczcj	297	29	125	125	CD
cord-260476-whfyczcj	297	30	]	]	-RRB-
cord-260476-whfyczcj	297	31	[	[	-LRB-
cord-260476-whfyczcj	297	32	126	126	CD
cord-260476-whfyczcj	297	33	]	]	-RRB-
cord-260476-whfyczcj	297	34	[	[	-LRB-
cord-260476-whfyczcj	297	35	127	127	CD
cord-260476-whfyczcj	297	36	]	]	-RRB-
cord-260476-whfyczcj	297	37	[	[	-LRB-
cord-260476-whfyczcj	297	38	128	128	CD
cord-260476-whfyczcj	297	39	]	]	-RRB-
cord-260476-whfyczcj	297	40	.	.	.
cord-260476-whfyczcj	298	1	Cell	cell	NN
cord-260476-whfyczcj	298	2	cycle	cycle	NN
cord-260476-whfyczcj	298	3	arrest	arrest	NN
cord-260476-whfyczcj	298	4	seems	seem	VBZ
cord-260476-whfyczcj	298	5	to	to	TO
cord-260476-whfyczcj	298	6	involve	involve	VB
cord-260476-whfyczcj	298	7	Vpr	Vpr	NNP
cord-260476-whfyczcj	298	8	association	association	NN
cord-260476-whfyczcj	298	9	with	with	IN
cord-260476-whfyczcj	298	10	the	the	DT
cord-260476-whfyczcj	298	11	SLX4-SLX1-MUS81-EME1	SLX4-SLX1-MUS81-EME1	NNP
cord-260476-whfyczcj	298	12	complex	complex	NN
cord-260476-whfyczcj	298	13	,	,	,
cord-260476-whfyczcj	298	14	leading	lead	VBG
cord-260476-whfyczcj	298	15	to	to	IN
cord-260476-whfyczcj	298	16	SLX4	SLX4	NNP
cord-260476-whfyczcj	298	17	(	(	-LRB-
cord-260476-whfyczcj	298	18	Structure	structure	NN
cord-260476-whfyczcj	298	19	-	-	HYPH
cord-260476-whfyczcj	298	20	specific	specific	JJ
cord-260476-whfyczcj	298	21	endonuclease	endonuclease	NN
cord-260476-whfyczcj	298	22	subunit	subunit	NN
cord-260476-whfyczcj	298	23	)	)	-RRB-
cord-260476-whfyczcj	298	24	activation	activation	NN
cord-260476-whfyczcj	298	25	and	and	CC
cord-260476-whfyczcj	298	26	ultimately	ultimately	RB
cord-260476-whfyczcj	298	27	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	298	28	degradation	degradation	NN
cord-260476-whfyczcj	298	29	of	of	IN
cord-260476-whfyczcj	298	30	MUS81	mus81	NN
cord-260476-whfyczcj	299	1	(	(	-LRB-
cord-260476-whfyczcj	299	2	Crossover	crossover	NN
cord-260476-whfyczcj	299	3	junction	junction	NN
cord-260476-whfyczcj	299	4	endonuclease	endonuclease	NN
cord-260476-whfyczcj	299	5	)	)	-RRB-
cord-260476-whfyczcj	299	6	and	and	CC
cord-260476-whfyczcj	299	7	EME1	EME1	NNP
cord-260476-whfyczcj	300	1	(	(	-LRB-
cord-260476-whfyczcj	300	2	Essential	Essential	NNP
cord-260476-whfyczcj	300	3	Meiotic	Meiotic	NNP
cord-260476-whfyczcj	300	4	Structure	Structure	NNP
cord-260476-whfyczcj	300	5	-	-	HYPH
cord-260476-whfyczcj	300	6	Specific	specific	JJ
cord-260476-whfyczcj	300	7	Endonuclease	Endonuclease	NNP
cord-260476-whfyczcj	300	8	1	1	CD
cord-260476-whfyczcj	300	9	)	)	-RRB-
cord-260476-whfyczcj	300	10	[	[	-LRB-
cord-260476-whfyczcj	300	11	127	127	CD
cord-260476-whfyczcj	300	12	,	,	,
cord-260476-whfyczcj	300	13	128	128	CD
cord-260476-whfyczcj	300	14	]	]	-RRB-
cord-260476-whfyczcj	300	15	.	.	.
cord-260476-whfyczcj	301	1	Vpr	Vpr	NNP
cord-260476-whfyczcj	301	2	also	also	RB
cord-260476-whfyczcj	301	3	induces	induce	VBZ
cord-260476-whfyczcj	301	4	the	the	DT
cord-260476-whfyczcj	301	5	degradation	degradation	NN
cord-260476-whfyczcj	301	6	of	of	IN
cord-260476-whfyczcj	301	7	multiple	multiple	JJ
cord-260476-whfyczcj	301	8	other	other	JJ
cord-260476-whfyczcj	301	9	cellular	cellular	JJ
cord-260476-whfyczcj	301	10	proteins	protein	NNS
cord-260476-whfyczcj	301	11	such	such	JJ
cord-260476-whfyczcj	301	12	as	as	IN
cord-260476-whfyczcj	301	13	the	the	DT
cord-260476-whfyczcj	301	14	DNA	dna	NN
cord-260476-whfyczcj	301	15	translocase	translocase	NN
cord-260476-whfyczcj	301	16	HLTF	HLTF	NNP
cord-260476-whfyczcj	302	1	(	(	-LRB-
cord-260476-whfyczcj	302	2	Helicase	Helicase	NNP
cord-260476-whfyczcj	302	3	-	-	HYPH
cord-260476-whfyczcj	302	4	Like	like	JJ
cord-260476-whfyczcj	302	5	Transcription	Transcription	NNP
cord-260476-whfyczcj	302	6	Factor	Factor	NNP
cord-260476-whfyczcj	302	7	)	)	-RRB-
cord-260476-whfyczcj	302	8	[	[	-LRB-
cord-260476-whfyczcj	302	9	171	171	CD
cord-260476-whfyczcj	302	10	]	]	-RRB-
cord-260476-whfyczcj	302	11	,	,	,
cord-260476-whfyczcj	302	12	the	the	DT
cord-260476-whfyczcj	302	13	DNA	dna	NN
cord-260476-whfyczcj	302	14	replication	replication	NN
cord-260476-whfyczcj	302	15	factor	factor	NN
cord-260476-whfyczcj	303	1	MCM10	mcm10	NN
cord-260476-whfyczcj	304	1	(	(	-LRB-
cord-260476-whfyczcj	304	2	Mini	Mini	NNP
cord-260476-whfyczcj	304	3	Chromosome	Chromosome	NNP
cord-260476-whfyczcj	304	4	Maintenance	Maintenance	NNP
cord-260476-whfyczcj	304	5	10	10	CD
cord-260476-whfyczcj	304	6	)	)	-RRB-
cord-260476-whfyczcj	304	7	[	[	-LRB-
cord-260476-whfyczcj	304	8	172	172	CD
cord-260476-whfyczcj	304	9	]	]	-RRB-
cord-260476-whfyczcj	304	10	,	,	,
cord-260476-whfyczcj	304	11	as	as	RB
cord-260476-whfyczcj	304	12	well	well	RB
cord-260476-whfyczcj	304	13	as	as	IN
cord-260476-whfyczcj	304	14	the	the	DT
cord-260476-whfyczcj	304	15	chromatin	chromatin	NN
cord-260476-whfyczcj	304	16	associated	associate	VBD
cord-260476-whfyczcj	304	17	proteins	protein	NNS
cord-260476-whfyczcj	304	18	ZIP	zip	NN
cord-260476-whfyczcj	305	1	(	(	-LRB-
cord-260476-whfyczcj	305	2	leucine	leucine	NNP
cord-260476-whfyczcj	305	3	Zipper	Zipper	NNP
cord-260476-whfyczcj	305	4	)	)	-RRB-
cord-260476-whfyczcj	305	5	,	,	,
cord-260476-whfyczcj	305	6	sZIP	szip	NN
cord-260476-whfyczcj	305	7	and	and	CC
cord-260476-whfyczcj	305	8	class	class	NN
cord-260476-whfyczcj	306	1	I	-PRON-	PRP
cord-260476-whfyczcj	306	2	HDACs	hdac	NNS
cord-260476-whfyczcj	306	3	(	(	-LRB-
cord-260476-whfyczcj	306	4	Histone	Histone	NNP
cord-260476-whfyczcj	306	5	Deacetylase	Deacetylase	NNP
cord-260476-whfyczcj	306	6	6	6	CD
cord-260476-whfyczcj	306	7	)	)	-RRB-
cord-260476-whfyczcj	307	1	[	[	-LRB-
cord-260476-whfyczcj	307	2	173	173	CD
cord-260476-whfyczcj	307	3	,	,	,
cord-260476-whfyczcj	307	4	174	174	CD
cord-260476-whfyczcj	307	5	]	]	-RRB-
cord-260476-whfyczcj	307	6	.	.	.
cord-260476-whfyczcj	308	1	The	the	DT
cord-260476-whfyczcj	308	2	UPS	UPS	NNP
cord-260476-whfyczcj	308	3	plays	play	VBZ
cord-260476-whfyczcj	308	4	an	an	DT
cord-260476-whfyczcj	308	5	important	important	JJ
cord-260476-whfyczcj	308	6	role	role	NN
cord-260476-whfyczcj	308	7	in	in	IN
cord-260476-whfyczcj	308	8	viral	viral	JJ
cord-260476-whfyczcj	308	9	infections	infection	NNS
cord-260476-whfyczcj	308	10	in	in	IN
cord-260476-whfyczcj	308	11	general	general	JJ
cord-260476-whfyczcj	308	12	and	and	CC
cord-260476-whfyczcj	308	13	especially	especially	RB
cord-260476-whfyczcj	308	14	in	in	IN
cord-260476-whfyczcj	308	15	the	the	DT
cord-260476-whfyczcj	308	16	process	process	NN
cord-260476-whfyczcj	308	17	of	of	IN
cord-260476-whfyczcj	308	18	viral	viral	JJ
cord-260476-whfyczcj	308	19	restriction	restriction	NN
cord-260476-whfyczcj	308	20	and	and	CC
cord-260476-whfyczcj	308	21	counter	counter	NN
cord-260476-whfyczcj	308	22	-	-	NN
cord-260476-whfyczcj	308	23	restriction	restriction	NN
cord-260476-whfyczcj	308	24	.	.	.
cord-260476-whfyczcj	309	1	In	in	IN
cord-260476-whfyczcj	309	2	this	this	DT
cord-260476-whfyczcj	309	3	continuous	continuous	JJ
cord-260476-whfyczcj	309	4	battle	battle	NN
cord-260476-whfyczcj	309	5	between	between	IN
cord-260476-whfyczcj	309	6	the	the	DT
cord-260476-whfyczcj	309	7	virus	virus	NN
cord-260476-whfyczcj	309	8	and	and	CC
cord-260476-whfyczcj	309	9	the	the	DT
cord-260476-whfyczcj	309	10	cell	cell	NN
cord-260476-whfyczcj	309	11	,	,	,
cord-260476-whfyczcj	309	12	the	the	DT
cord-260476-whfyczcj	309	13	UPS	UPS	NNP
cord-260476-whfyczcj	309	14	constitutes	constitute	VBZ
cord-260476-whfyczcj	309	15	an	an	DT
cord-260476-whfyczcj	309	16	efficient	efficient	JJ
cord-260476-whfyczcj	309	17	tool	tool	NN
cord-260476-whfyczcj	309	18	for	for	IN
cord-260476-whfyczcj	309	19	both	both	DT
cord-260476-whfyczcj	309	20	sides	side	NNS
cord-260476-whfyczcj	309	21	.	.	.
cord-260476-whfyczcj	310	1	Several	several	JJ
cord-260476-whfyczcj	310	2	HIV	HIV	NNP
cord-260476-whfyczcj	310	3	auxiliary	auxiliary	JJ
cord-260476-whfyczcj	310	4	proteins	protein	NNS
cord-260476-whfyczcj	310	5	have	have	VBP
cord-260476-whfyczcj	310	6	evolved	evolve	VBN
cord-260476-whfyczcj	310	7	the	the	DT
cord-260476-whfyczcj	310	8	ability	ability	NN
cord-260476-whfyczcj	310	9	to	to	TO
cord-260476-whfyczcj	310	10	interact	interact	VB
cord-260476-whfyczcj	310	11	with	with	IN
cord-260476-whfyczcj	310	12	components	component	NNS
cord-260476-whfyczcj	310	13	of	of	IN
cord-260476-whfyczcj	310	14	the	the	DT
cord-260476-whfyczcj	310	15	UPS	up	NNS
cord-260476-whfyczcj	310	16	,	,	,
cord-260476-whfyczcj	310	17	subverting	subvert	VBG
cord-260476-whfyczcj	310	18	it	-PRON-	PRP
cord-260476-whfyczcj	310	19	for	for	IN
cord-260476-whfyczcj	310	20	its	-PRON-	PRP$
cord-260476-whfyczcj	310	21	own	own	JJ
cord-260476-whfyczcj	310	22	means	mean	NNS
cord-260476-whfyczcj	310	23	.	.	.
cord-260476-whfyczcj	311	1	This	this	DT
cord-260476-whfyczcj	311	2	allows	allow	VBZ
cord-260476-whfyczcj	311	3	the	the	DT
cord-260476-whfyczcj	311	4	targeting	targeting	NN
cord-260476-whfyczcj	311	5	of	of	IN
cord-260476-whfyczcj	311	6	a	a	DT
cord-260476-whfyczcj	311	7	multitude	multitude	NN
cord-260476-whfyczcj	311	8	of	of	IN
cord-260476-whfyczcj	311	9	different	different	JJ
cord-260476-whfyczcj	311	10	cellular	cellular	JJ
cord-260476-whfyczcj	311	11	proteins	protein	NNS
cord-260476-whfyczcj	311	12	through	through	IN
cord-260476-whfyczcj	311	13	a	a	DT
cord-260476-whfyczcj	311	14	single	single	JJ
cord-260476-whfyczcj	311	15	platform	platform	NN
cord-260476-whfyczcj	311	16	.	.	.
cord-260476-whfyczcj	312	1	This	this	DT
cord-260476-whfyczcj	312	2	strategy	strategy	NN
cord-260476-whfyczcj	312	3	is	be	VBZ
cord-260476-whfyczcj	312	4	not	not	RB
cord-260476-whfyczcj	312	5	limited	limited	JJ
cord-260476-whfyczcj	312	6	to	to	IN
cord-260476-whfyczcj	312	7	HIV	HIV	NNP
cord-260476-whfyczcj	312	8	,	,	,
cord-260476-whfyczcj	312	9	but	but	CC
cord-260476-whfyczcj	312	10	is	be	VBZ
cord-260476-whfyczcj	312	11	used	use	VBN
cord-260476-whfyczcj	312	12	by	by	IN
cord-260476-whfyczcj	312	13	a	a	DT
cord-260476-whfyczcj	312	14	plethora	plethora	NN
cord-260476-whfyczcj	312	15	of	of	IN
cord-260476-whfyczcj	312	16	different	different	JJ
cord-260476-whfyczcj	312	17	viruses	virus	NNS
cord-260476-whfyczcj	312	18	to	to	TO
cord-260476-whfyczcj	312	19	ensure	ensure	VB
cord-260476-whfyczcj	312	20	various	various	JJ
cord-260476-whfyczcj	312	21	aspects	aspect	NNS
cord-260476-whfyczcj	312	22	of	of	IN
cord-260476-whfyczcj	312	23	their	-PRON-	PRP$
cord-260476-whfyczcj	312	24	life	life	NN
cord-260476-whfyczcj	312	25	cycles	cycle	NNS
cord-260476-whfyczcj	312	26	.	.	.
cord-260476-whfyczcj	313	1	Overall	overall	RB
cord-260476-whfyczcj	313	2	,	,	,
cord-260476-whfyczcj	313	3	the	the	DT
cord-260476-whfyczcj	313	4	specific	specific	JJ
cord-260476-whfyczcj	313	5	degradation	degradation	NN
cord-260476-whfyczcj	313	6	of	of	IN
cord-260476-whfyczcj	313	7	certain	certain	JJ
cord-260476-whfyczcj	313	8	cellular	cellular	JJ
cord-260476-whfyczcj	313	9	proteins	protein	NNS
cord-260476-whfyczcj	313	10	in	in	IN
cord-260476-whfyczcj	313	11	the	the	DT
cord-260476-whfyczcj	313	12	UPS	UPS	NNP
cord-260476-whfyczcj	313	13	allows	allow	VBZ
cord-260476-whfyczcj	313	14	viruses	virus	NNS
cord-260476-whfyczcj	313	15	to	to	TO
cord-260476-whfyczcj	313	16	generate	generate	VB
cord-260476-whfyczcj	313	17	a	a	DT
cord-260476-whfyczcj	313	18	favorable	favorable	JJ
cord-260476-whfyczcj	313	19	environment	environment	NN
cord-260476-whfyczcj	313	20	for	for	IN
cord-260476-whfyczcj	313	21	their	-PRON-	PRP$
cord-260476-whfyczcj	313	22	own	own	JJ
cord-260476-whfyczcj	313	23	replication	replication	NN
cord-260476-whfyczcj	313	24	.	.	.
cord-260476-whfyczcj	314	1	The	the	DT
cord-260476-whfyczcj	314	2	almost	almost	RB
cord-260476-whfyczcj	314	3	universal	universal	JJ
cord-260476-whfyczcj	314	4	role	role	NN
cord-260476-whfyczcj	314	5	of	of	IN
cord-260476-whfyczcj	314	6	the	the	DT
cord-260476-whfyczcj	314	7	UPS	up	NNS
cord-260476-whfyczcj	314	8	in	in	IN
cord-260476-whfyczcj	314	9	counteraction	counteraction	NN
cord-260476-whfyczcj	314	10	of	of	IN
cord-260476-whfyczcj	314	11	cellular	cellular	JJ
cord-260476-whfyczcj	314	12	restriction	restriction	NN
cord-260476-whfyczcj	314	13	factors	factor	NNS
cord-260476-whfyczcj	314	14	by	by	IN
cord-260476-whfyczcj	314	15	HIV	HIV	NNP
cord-260476-whfyczcj	314	16	makes	make	VBZ
cord-260476-whfyczcj	314	17	the	the	DT
cord-260476-whfyczcj	314	18	UPS	UPS	NNP
cord-260476-whfyczcj	314	19	an	an	DT
cord-260476-whfyczcj	314	20	interesting	interesting	JJ
cord-260476-whfyczcj	314	21	target	target	NN
cord-260476-whfyczcj	314	22	for	for	IN
cord-260476-whfyczcj	314	23	antiviral	antiviral	JJ
cord-260476-whfyczcj	314	24	therapy	therapy	NN
cord-260476-whfyczcj	314	25	.	.	.
cord-260476-whfyczcj	315	1	One	one	CD
cord-260476-whfyczcj	315	2	of	of	IN
cord-260476-whfyczcj	315	3	the	the	DT
cord-260476-whfyczcj	315	4	main	main	JJ
cord-260476-whfyczcj	315	5	difficulties	difficulty	NNS
cord-260476-whfyczcj	315	6	in	in	IN
cord-260476-whfyczcj	315	7	therapy	therapy	NN
cord-260476-whfyczcj	315	8	-	-	HYPH
cord-260476-whfyczcj	315	9	design	design	NN
cord-260476-whfyczcj	315	10	against	against	IN
cord-260476-whfyczcj	315	11	HIV	HIV	NNP
cord-260476-whfyczcj	315	12	is	be	VBZ
cord-260476-whfyczcj	315	13	the	the	DT
cord-260476-whfyczcj	315	14	rapid	rapid	JJ
cord-260476-whfyczcj	315	15	evolution	evolution	NN
cord-260476-whfyczcj	315	16	of	of	IN
cord-260476-whfyczcj	315	17	the	the	DT
cord-260476-whfyczcj	315	18	virus	virus	NN
cord-260476-whfyczcj	315	19	,	,	,
cord-260476-whfyczcj	315	20	which	which	WDT
cord-260476-whfyczcj	315	21	easily	easily	RB
cord-260476-whfyczcj	315	22	escapes	escape	VBZ
cord-260476-whfyczcj	315	23	therapeutic	therapeutic	JJ
cord-260476-whfyczcj	315	24	molecules	molecule	NNS
cord-260476-whfyczcj	315	25	by	by	IN
cord-260476-whfyczcj	315	26	mutation	mutation	NN
cord-260476-whfyczcj	315	27	of	of	IN
cord-260476-whfyczcj	315	28	the	the	DT
cord-260476-whfyczcj	315	29	targeted	target	VBN
cord-260476-whfyczcj	315	30	viral	viral	JJ
cord-260476-whfyczcj	315	31	proteins	protein	NNS
cord-260476-whfyczcj	315	32	.	.	.
cord-260476-whfyczcj	316	1	Targeting	target	VBG
cord-260476-whfyczcj	316	2	the	the	DT
cord-260476-whfyczcj	316	3	human	human	JJ
cord-260476-whfyczcj	316	4	UPS	UPS	NNP
cord-260476-whfyczcj	316	5	represents	represent	VBZ
cord-260476-whfyczcj	316	6	a	a	DT
cord-260476-whfyczcj	316	7	promising	promising	JJ
cord-260476-whfyczcj	316	8	antiviral	antiviral	JJ
cord-260476-whfyczcj	316	9	strategy	strategy	NN
cord-260476-whfyczcj	316	10	because	because	IN
cord-260476-whfyczcj	316	11	it	-PRON-	PRP
cord-260476-whfyczcj	316	12	would	would	MD
cord-260476-whfyczcj	316	13	allow	allow	VB
cord-260476-whfyczcj	316	14	to	to	TO
cord-260476-whfyczcj	316	15	avoid	avoid	VB
cord-260476-whfyczcj	316	16	the	the	DT
cord-260476-whfyczcj	316	17	escape	escape	NN
cord-260476-whfyczcj	316	18	through	through	IN
cord-260476-whfyczcj	316	19	mutations	mutation	NNS
cord-260476-whfyczcj	316	20	[	[	-LRB-
cord-260476-whfyczcj	316	21	175	175	CD
cord-260476-whfyczcj	316	22	,	,	,
cord-260476-whfyczcj	316	23	176	176	CD
cord-260476-whfyczcj	316	24	]	]	-RRB-
cord-260476-whfyczcj	316	25	.	.	.
cord-260476-whfyczcj	317	1	A	a	DT
cord-260476-whfyczcj	317	2	better	well	JJR
cord-260476-whfyczcj	317	3	knowledge	knowledge	NN
cord-260476-whfyczcj	317	4	on	on	IN
cord-260476-whfyczcj	317	5	how	how	WRB
cord-260476-whfyczcj	317	6	the	the	DT
cord-260476-whfyczcj	317	7	virus	virus	NN
cord-260476-whfyczcj	317	8	hijacks	hijack	VBZ
cord-260476-whfyczcj	317	9	the	the	DT
cord-260476-whfyczcj	317	10	UPS	UPS	NNPS
cord-260476-whfyczcj	317	11	and	and	CC
cord-260476-whfyczcj	317	12	which	which	WDT
cord-260476-whfyczcj	317	13	components	component	NNS
cord-260476-whfyczcj	317	14	are	be	VBP
cord-260476-whfyczcj	317	15	involved	involve	VBN
cord-260476-whfyczcj	317	16	in	in	IN
cord-260476-whfyczcj	317	17	viral	viral	JJ
cord-260476-whfyczcj	317	18	replication	replication	NN
cord-260476-whfyczcj	317	19	is	be	VBZ
cord-260476-whfyczcj	317	20	crucial	crucial	JJ
cord-260476-whfyczcj	317	21	in	in	IN
cord-260476-whfyczcj	317	22	this	this	DT
cord-260476-whfyczcj	317	23	attempt	attempt	NN
cord-260476-whfyczcj	317	24	.	.	.
cord-260476-whfyczcj	318	1	Structure	structure	NN
cord-260476-whfyczcj	318	2	and	and	CC
cord-260476-whfyczcj	318	3	function	function	NN
cord-260476-whfyczcj	318	4	of	of	IN
cord-260476-whfyczcj	318	5	viral	viral	JJ
cord-260476-whfyczcj	318	6	deubiquitinating	deubiquitinating	NN
cord-260476-whfyczcj	318	7	enzymes	enzyme	NNS
cord-260476-whfyczcj	319	1	The	the	DT
cord-260476-whfyczcj	319	2	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	319	3	-	-	HYPH
cord-260476-whfyczcj	319	4	proteasome	proteasome	VBN
cord-260476-whfyczcj	319	5	pathway	pathway	NN
cord-260476-whfyczcj	319	6	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	319	7	:	:	:
cord-260476-whfyczcj	320	1	Same	same	JJ
cord-260476-whfyczcj	320	2	molecule	molecule	NN
cord-260476-whfyczcj	320	3	,	,	,
cord-260476-whfyczcj	320	4	different	different	JJ
cord-260476-whfyczcj	320	5	degradation	degradation	NN
cord-260476-whfyczcj	320	6	pathways	pathway	NNS
cord-260476-whfyczcj	320	7	Ubiquitination	Ubiquitination	NNP
cord-260476-whfyczcj	320	8	in	in	IN
cord-260476-whfyczcj	320	9	the	the	DT
cord-260476-whfyczcj	320	10	antiviral	antiviral	JJ
cord-260476-whfyczcj	320	11	immune	immune	JJ
cord-260476-whfyczcj	320	12	response	response	NN
cord-260476-whfyczcj	320	13	Function	function	NN
cord-260476-whfyczcj	320	14	and	and	CC
cord-260476-whfyczcj	320	15	regulation	regulation	NN
cord-260476-whfyczcj	320	16	of	of	IN
cord-260476-whfyczcj	320	17	cullin	cullin	NN
cord-260476-whfyczcj	320	18	-	-	HYPH
cord-260476-whfyczcj	320	19	RING	ring	NN
cord-260476-whfyczcj	320	20	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	320	21	ligases	ligase	NNS
cord-260476-whfyczcj	321	1	Components	component	NNS
cord-260476-whfyczcj	321	2	of	of	IN
cord-260476-whfyczcj	321	3	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	321	4	-	-	HYPH
cord-260476-whfyczcj	321	5	protein	protein	NN
cord-260476-whfyczcj	321	6	ligase	ligase	NN
cord-260476-whfyczcj	321	7	system	system	NN
cord-260476-whfyczcj	321	8	.	.	.
cord-260476-whfyczcj	322	1	Resolution	resolution	NN
cord-260476-whfyczcj	322	2	,	,	,
cord-260476-whfyczcj	322	3	affinity	affinity	NN
cord-260476-whfyczcj	322	4	purification	purification	NN
cord-260476-whfyczcj	322	5	,	,	,
cord-260476-whfyczcj	322	6	and	and	CC
cord-260476-whfyczcj	322	7	role	role	NN
cord-260476-whfyczcj	322	8	in	in	IN
cord-260476-whfyczcj	322	9	protein	protein	NN
cord-260476-whfyczcj	322	10	breakdown	breakdown	NN
cord-260476-whfyczcj	322	11	Protein	Protein	NNP
cord-260476-whfyczcj	322	12	ubiquitination	ubiquitination	IN
cord-260476-whfyczcj	322	13	involving	involve	VBG
cord-260476-whfyczcj	322	14	an	an	DT
cord-260476-whfyczcj	322	15	E1-E2-E3	E1-E2-E3	NNP
cord-260476-whfyczcj	322	16	enzyme	enzyme	NN
cord-260476-whfyczcj	322	17	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	322	18	thioester	thioester	NN
cord-260476-whfyczcj	322	19	cascade	cascade	VB
cord-260476-whfyczcj	322	20	A	a	DT
cord-260476-whfyczcj	322	21	uniform	uniform	JJ
cord-260476-whfyczcj	322	22	isopeptide	isopeptide	NN
cord-260476-whfyczcj	322	23	-	-	HYPH
cord-260476-whfyczcj	322	24	linked	link	VBN
cord-260476-whfyczcj	322	25	multiubiquitin	multiubiquitin	NN
cord-260476-whfyczcj	322	26	chain	chain	NN
cord-260476-whfyczcj	322	27	is	be	VBZ
cord-260476-whfyczcj	322	28	sufficient	sufficient	JJ
cord-260476-whfyczcj	322	29	to	to	TO
cord-260476-whfyczcj	322	30	target	target	VB
cord-260476-whfyczcj	322	31	substrate	substrate	NN
cord-260476-whfyczcj	322	32	for	for	IN
cord-260476-whfyczcj	322	33	degradation	degradation	NN
cord-260476-whfyczcj	322	34	in	in	IN
cord-260476-whfyczcj	322	35	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	322	36	-	-	HYPH
cord-260476-whfyczcj	322	37	mediated	mediate	VBN
cord-260476-whfyczcj	322	38	proteolysis	proteolysis	NN
cord-260476-whfyczcj	323	1	A	a	DT
cord-260476-whfyczcj	323	2	multiubiquitin	multiubiquitin	NN
cord-260476-whfyczcj	323	3	chain	chain	NN
cord-260476-whfyczcj	323	4	is	be	VBZ
cord-260476-whfyczcj	323	5	confined	confine	VBN
cord-260476-whfyczcj	323	6	to	to	IN
cord-260476-whfyczcj	323	7	specific	specific	JJ
cord-260476-whfyczcj	323	8	lysine	lysine	NN
cord-260476-whfyczcj	323	9	in	in	IN
cord-260476-whfyczcj	323	10	a	a	DT
cord-260476-whfyczcj	323	11	targeted	target	VBN
cord-260476-whfyczcj	323	12	short	short	RB
cord-260476-whfyczcj	323	13	-	-	HYPH
cord-260476-whfyczcj	323	14	lived	live	VBN
cord-260476-whfyczcj	323	15	protein	protein	NN
cord-260476-whfyczcj	324	1	The	the	DT
cord-260476-whfyczcj	324	2	logic	logic	NN
cord-260476-whfyczcj	324	3	of	of	IN
cord-260476-whfyczcj	324	4	the	the	DT
cord-260476-whfyczcj	324	5	26S	26S	NNP
cord-260476-whfyczcj	324	6	proteasome	proteasome	VBN
cord-260476-whfyczcj	324	7	Involvement	Involvement	NNP
cord-260476-whfyczcj	324	8	of	of	IN
cord-260476-whfyczcj	324	9	the	the	DT
cord-260476-whfyczcj	324	10	proteasome	proteasome	NN
cord-260476-whfyczcj	324	11	in	in	IN
cord-260476-whfyczcj	324	12	various	various	JJ
cord-260476-whfyczcj	324	13	degradative	degradative	JJ
cord-260476-whfyczcj	324	14	processes	process	NNS
cord-260476-whfyczcj	324	15	in	in	IN
cord-260476-whfyczcj	324	16	mammalian	mammalian	JJ
cord-260476-whfyczcj	324	17	cells	cell	NNS
cord-260476-whfyczcj	325	1	Ubp6	Ubp6	NNP
cord-260476-whfyczcj	325	2	deubiquitinase	deubiquitinase	NN
cord-260476-whfyczcj	325	3	controls	control	VBZ
cord-260476-whfyczcj	325	4	conformational	conformational	JJ
cord-260476-whfyczcj	325	5	dynamics	dynamic	NNS
cord-260476-whfyczcj	325	6	and	and	CC
cord-260476-whfyczcj	325	7	substrate	substrate	JJ
cord-260476-whfyczcj	325	8	degradation	degradation	NN
cord-260476-whfyczcj	325	9	of	of	IN
cord-260476-whfyczcj	325	10	the	the	DT
cord-260476-whfyczcj	325	11	26S	26S	NNP
cord-260476-whfyczcj	325	12	proteasome	proteasome	VBD
cord-260476-whfyczcj	325	13	Redundant	redundant	JJ
cord-260476-whfyczcj	325	14	roles	role	NNS
cord-260476-whfyczcj	325	15	of	of	IN
cord-260476-whfyczcj	325	16	rpn10	rpn10	NNS
cord-260476-whfyczcj	325	17	and	and	CC
cord-260476-whfyczcj	325	18	rpn13	rpn13	NFP
cord-260476-whfyczcj	325	19	in	in	IN
cord-260476-whfyczcj	325	20	recognition	recognition	NN
cord-260476-whfyczcj	325	21	of	of	IN
cord-260476-whfyczcj	325	22	ubiquitinated	ubiquitinated	JJ
cord-260476-whfyczcj	325	23	proteins	protein	NNS
cord-260476-whfyczcj	325	24	and	and	CC
cord-260476-whfyczcj	325	25	cellular	cellular	JJ
cord-260476-whfyczcj	325	26	homeostasis	homeostasis	NN
cord-260476-whfyczcj	325	27	Crystal	Crystal	NNP
cord-260476-whfyczcj	325	28	structure	structure	NN
cord-260476-whfyczcj	325	29	of	of	IN
cord-260476-whfyczcj	325	30	the	the	DT
cord-260476-whfyczcj	325	31	human	human	JJ
cord-260476-whfyczcj	325	32	20S	20s	CD
cord-260476-whfyczcj	325	33	proteasome	proteasome	VBN
cord-260476-whfyczcj	325	34	in	in	IN
cord-260476-whfyczcj	325	35	complex	complex	NN
cord-260476-whfyczcj	325	36	with	with	IN
cord-260476-whfyczcj	325	37	carfilzomib	carfilzomib	NNP
cord-260476-whfyczcj	326	1	The	the	DT
cord-260476-whfyczcj	326	2	Escrt	Escrt	NNP
cord-260476-whfyczcj	326	3	complexes	complex	NNS
cord-260476-whfyczcj	326	4	:	:	:
cord-260476-whfyczcj	327	1	Structure	structure	NN
cord-260476-whfyczcj	327	2	and	and	CC
cord-260476-whfyczcj	327	3	mechanism	mechanism	NN
cord-260476-whfyczcj	327	4	of	of	IN
cord-260476-whfyczcj	327	5	a	a	DT
cord-260476-whfyczcj	327	6	membrane	membrane	NN
cord-260476-whfyczcj	327	7	-	-	HYPH
cord-260476-whfyczcj	327	8	trafficking	traffic	VBG
cord-260476-whfyczcj	327	9	network	network	NN
cord-260476-whfyczcj	327	10	K63-linked	K63-linked	NNP
cord-260476-whfyczcj	327	11	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	327	12	chains	chain	NNS
cord-260476-whfyczcj	327	13	as	as	IN
cord-260476-whfyczcj	327	14	a	a	DT
cord-260476-whfyczcj	327	15	specific	specific	JJ
cord-260476-whfyczcj	327	16	signal	signal	NN
cord-260476-whfyczcj	327	17	for	for	IN
cord-260476-whfyczcj	327	18	protein	protein	NN
cord-260476-whfyczcj	327	19	sorting	sorting	NN
cord-260476-whfyczcj	327	20	into	into	IN
cord-260476-whfyczcj	327	21	the	the	DT
cord-260476-whfyczcj	327	22	multivesicular	multivesicular	NNP
cord-260476-whfyczcj	327	23	body	body	NN
cord-260476-whfyczcj	327	24	pathway	pathway	NN
cord-260476-whfyczcj	327	25	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	327	26	-	-	HYPH
cord-260476-whfyczcj	327	27	dependent	dependent	JJ
cord-260476-whfyczcj	327	28	sorting	sorting	NN
cord-260476-whfyczcj	327	29	into	into	IN
cord-260476-whfyczcj	327	30	the	the	DT
cord-260476-whfyczcj	327	31	multivesicular	multivesicular	NNP
cord-260476-whfyczcj	327	32	body	body	NN
cord-260476-whfyczcj	327	33	pathway	pathway	NN
cord-260476-whfyczcj	327	34	requires	require	VBZ
cord-260476-whfyczcj	327	35	the	the	DT
cord-260476-whfyczcj	327	36	function	function	NN
cord-260476-whfyczcj	327	37	of	of	IN
cord-260476-whfyczcj	327	38	a	a	DT
cord-260476-whfyczcj	327	39	conserved	conserved	JJ
cord-260476-whfyczcj	327	40	endosomal	endosomal	NNP
cord-260476-whfyczcj	327	41	protein	protein	NN
cord-260476-whfyczcj	327	42	sorting	sort	VBG
cord-260476-whfyczcj	327	43	complex	complex	NN
cord-260476-whfyczcj	327	44	,	,	,
cord-260476-whfyczcj	327	45	ESCRT	ESCRT	NNP
cord-260476-whfyczcj	327	46	-	-	HYPH
cord-260476-whfyczcj	327	47	I	I	NNP
cord-260476-whfyczcj	328	1	The	the	DT
cord-260476-whfyczcj	328	2	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	328	3	-	-	HYPH
cord-260476-whfyczcj	328	4	conjugating	conjugate	VBG
cord-260476-whfyczcj	328	5	system	system	NN
cord-260476-whfyczcj	328	6	:	:	:
cord-260476-whfyczcj	328	7	Multiple	multiple	JJ
cord-260476-whfyczcj	328	8	roles	role	NNS
cord-260476-whfyczcj	328	9	in	in	IN
cord-260476-whfyczcj	328	10	viral	viral	JJ
cord-260476-whfyczcj	328	11	replication	replication	NN
cord-260476-whfyczcj	328	12	and	and	CC
cord-260476-whfyczcj	328	13	infection	infection	NN
cord-260476-whfyczcj	328	14	Viral	viral	JJ
cord-260476-whfyczcj	328	15	avoidance	avoidance	NN
cord-260476-whfyczcj	328	16	and	and	CC
cord-260476-whfyczcj	328	17	exploitation	exploitation	NN
cord-260476-whfyczcj	328	18	of	of	IN
cord-260476-whfyczcj	328	19	the	the	DT
cord-260476-whfyczcj	328	20	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	328	21	system	system	NN
cord-260476-whfyczcj	328	22	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	328	23	,	,	,
cord-260476-whfyczcj	328	24	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	328	25	and	and	CC
cord-260476-whfyczcj	328	26	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	328	27	-	-	HYPH
cord-260476-whfyczcj	328	28	like	like	JJ
cord-260476-whfyczcj	328	29	proteins	protein	NNS
cord-260476-whfyczcj	328	30	:	:	:
cord-260476-whfyczcj	328	31	The	the	DT
cord-260476-whfyczcj	328	32	dialectic	dialectic	JJ
cord-260476-whfyczcj	328	33	interactions	interaction	NNS
cord-260476-whfyczcj	328	34	of	of	IN
cord-260476-whfyczcj	328	35	a	a	DT
cord-260476-whfyczcj	328	36	virus	virus	NN
cord-260476-whfyczcj	328	37	with	with	IN
cord-260476-whfyczcj	328	38	a	a	DT
cord-260476-whfyczcj	328	39	sophisticated	sophisticated	JJ
cord-260476-whfyczcj	328	40	network	network	NN
cord-260476-whfyczcj	328	41	of	of	IN
cord-260476-whfyczcj	328	42	post	post	JJ
cord-260476-whfyczcj	328	43	-	-	JJ
cord-260476-whfyczcj	328	44	translational	translational	JJ
cord-260476-whfyczcj	328	45	modifications	modification	NNS
cord-260476-whfyczcj	329	1	Ubiquitin	Ubiquitin	NNP
cord-260476-whfyczcj	329	2	is	be	VBZ
cord-260476-whfyczcj	329	3	covalently	covalently	RB
cord-260476-whfyczcj	329	4	attached	attach	VBN
cord-260476-whfyczcj	329	5	to	to	IN
cord-260476-whfyczcj	329	6	the	the	DT
cord-260476-whfyczcj	329	7	p6Gag	p6Gag	NNP
cord-260476-whfyczcj	329	8	proteins	protein	NNS
cord-260476-whfyczcj	329	9	of	of	IN
cord-260476-whfyczcj	329	10	human	human	JJ
cord-260476-whfyczcj	329	11	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	329	12	virus	virus	NN
cord-260476-whfyczcj	329	13	type	type	NN
cord-260476-whfyczcj	329	14	1	1	CD
cord-260476-whfyczcj	329	15	and	and	CC
cord-260476-whfyczcj	329	16	simian	simian	JJ
cord-260476-whfyczcj	329	17	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	329	18	virus	virus	NN
cord-260476-whfyczcj	329	19	and	and	CC
cord-260476-whfyczcj	329	20	to	to	IN
cord-260476-whfyczcj	329	21	the	the	DT
cord-260476-whfyczcj	329	22	p12Gag	p12Gag	NNP
cord-260476-whfyczcj	329	23	protein	protein	NN
cord-260476-whfyczcj	329	24	of	of	IN
cord-260476-whfyczcj	329	25	moloney	moloney	NNP
cord-260476-whfyczcj	329	26	murine	murine	NNP
cord-260476-whfyczcj	329	27	leukemia	leukemia	NN
cord-260476-whfyczcj	329	28	virus	virus	NN
cord-260476-whfyczcj	329	29	Cumulative	cumulative	JJ
cord-260476-whfyczcj	329	30	mutations	mutation	NNS
cord-260476-whfyczcj	329	31	of	of	IN
cord-260476-whfyczcj	329	32	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	329	33	acceptor	acceptor	NN
cord-260476-whfyczcj	329	34	sites	site	NNS
cord-260476-whfyczcj	329	35	in	in	IN
cord-260476-whfyczcj	329	36	human	human	JJ
cord-260476-whfyczcj	329	37	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	329	38	virus	virus	NN
cord-260476-whfyczcj	329	39	type	type	NN
cord-260476-whfyczcj	329	40	1	1	CD
cord-260476-whfyczcj	329	41	gag	gag	NN
cord-260476-whfyczcj	329	42	cause	cause	VBP
cord-260476-whfyczcj	329	43	a	a	DT
cord-260476-whfyczcj	329	44	late	late	JJ
cord-260476-whfyczcj	329	45	budding	budding	NN
cord-260476-whfyczcj	329	46	defect	defect	NN
cord-260476-whfyczcj	330	1	Tsg101	Tsg101	NNP
cord-260476-whfyczcj	330	2	and	and	CC
cord-260476-whfyczcj	330	3	the	the	DT
cord-260476-whfyczcj	330	4	vacuolar	vacuolar	NNP
cord-260476-whfyczcj	330	5	protein	protein	NN
cord-260476-whfyczcj	330	6	sorting	sort	VBG
cord-260476-whfyczcj	330	7	pathway	pathway	NN
cord-260476-whfyczcj	330	8	are	be	VBP
cord-260476-whfyczcj	330	9	essential	essential	JJ
cord-260476-whfyczcj	330	10	for	for	IN
cord-260476-whfyczcj	330	11	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	330	12	budding	bud	VBG
cord-260476-whfyczcj	330	13	Ubiquitination	Ubiquitination	NNP
cord-260476-whfyczcj	330	14	of	of	IN
cord-260476-whfyczcj	330	15	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	330	16	and	and	CC
cord-260476-whfyczcj	330	17	MuLV	MuLV	NNP
cord-260476-whfyczcj	331	1	Gag	gag	VB
cord-260476-whfyczcj	331	2	A	a	DT
cord-260476-whfyczcj	331	3	non	non	JJ
cord-260476-whfyczcj	331	4	-	-	JJ
cord-260476-whfyczcj	331	5	proteolytic	proteolytic	JJ
cord-260476-whfyczcj	331	6	role	role	NN
cord-260476-whfyczcj	331	7	for	for	IN
cord-260476-whfyczcj	331	8	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	331	9	in	in	IN
cord-260476-whfyczcj	331	10	Tat	tat	NN
cord-260476-whfyczcj	331	11	-	-	HYPH
cord-260476-whfyczcj	331	12	mediated	mediate	VBN
cord-260476-whfyczcj	331	13	transactivation	transactivation	NN
cord-260476-whfyczcj	331	14	of	of	IN
cord-260476-whfyczcj	331	15	the	the	DT
cord-260476-whfyczcj	331	16	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	331	17	promoter	promoter	NN
cord-260476-whfyczcj	331	18	PJA2	PJA2	NNP
cord-260476-whfyczcj	331	19	ubiquitinates	ubiquitinate	VBZ
cord-260476-whfyczcj	331	20	the	the	DT
cord-260476-whfyczcj	331	21	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	331	22	Tat	Tat	NNP
cord-260476-whfyczcj	331	23	protein	protein	NN
cord-260476-whfyczcj	331	24	with	with	IN
cord-260476-whfyczcj	331	25	atypical	atypical	JJ
cord-260476-whfyczcj	331	26	chain	chain	NN
cord-260476-whfyczcj	331	27	linkages	linkage	NNS
cord-260476-whfyczcj	331	28	to	to	TO
cord-260476-whfyczcj	331	29	activate	activate	VB
cord-260476-whfyczcj	331	30	viral	viral	JJ
cord-260476-whfyczcj	331	31	transcription	transcription	NN
cord-260476-whfyczcj	332	1	TRIM32	TRIM32	NNP
cord-260476-whfyczcj	332	2	senses	sense	NNS
cord-260476-whfyczcj	332	3	and	and	CC
cord-260476-whfyczcj	332	4	restricts	restrict	VBZ
cord-260476-whfyczcj	332	5	influenza	influenza	NN
cord-260476-whfyczcj	332	6	a	a	DT
cord-260476-whfyczcj	332	7	virus	virus	NN
cord-260476-whfyczcj	332	8	by	by	IN
cord-260476-whfyczcj	332	9	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	332	10	of	of	IN
cord-260476-whfyczcj	332	11	PB1	pb1	NN
cord-260476-whfyczcj	332	12	polymerase	polymerase	NN
cord-260476-whfyczcj	333	1	The	the	DT
cord-260476-whfyczcj	333	2	TRIMendous	trimendous	JJ
cord-260476-whfyczcj	333	3	role	role	NN
cord-260476-whfyczcj	333	4	of	of	IN
cord-260476-whfyczcj	333	5	TRIMs	trim	NNS
cord-260476-whfyczcj	333	6	in	in	IN
cord-260476-whfyczcj	333	7	virus	virus	NN
cord-260476-whfyczcj	333	8	-	-	HYPH
cord-260476-whfyczcj	333	9	host	host	NN
cord-260476-whfyczcj	333	10	interactions	interaction	NNS
cord-260476-whfyczcj	334	1	Proteasomal	proteasomal	JJ
cord-260476-whfyczcj	334	2	degradation	degradation	NN
cord-260476-whfyczcj	334	3	of	of	IN
cord-260476-whfyczcj	334	4	herpes	herpes	NNP
cord-260476-whfyczcj	334	5	simplex	simplex	NNP
cord-260476-whfyczcj	334	6	virus	virus	NN
cord-260476-whfyczcj	334	7	capsids	capsid	VBZ
cord-260476-whfyczcj	334	8	in	in	IN
cord-260476-whfyczcj	334	9	macrophages	macrophages	NN
cord-260476-whfyczcj	334	10	releases	release	NNS
cord-260476-whfyczcj	334	11	DNA	DNA	NNP
cord-260476-whfyczcj	334	12	to	to	IN
cord-260476-whfyczcj	334	13	the	the	DT
cord-260476-whfyczcj	334	14	cytosol	cytosol	NN
cord-260476-whfyczcj	334	15	for	for	IN
cord-260476-whfyczcj	334	16	recognition	recognition	NN
cord-260476-whfyczcj	334	17	by	by	IN
cord-260476-whfyczcj	334	18	DNA	dna	NN
cord-260476-whfyczcj	334	19	sensors	sensor	NNS
cord-260476-whfyczcj	335	1	Simian	simian	JJ
cord-260476-whfyczcj	335	2	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	335	3	proteins	protein	NNS
cord-260476-whfyczcj	335	4	reduce	reduce	VBP
cord-260476-whfyczcj	335	5	replication	replication	NN
cord-260476-whfyczcj	335	6	of	of	IN
cord-260476-whfyczcj	335	7	herpes	herpes	NN
cord-260476-whfyczcj	335	8	simplex	simplex	NNP
cord-260476-whfyczcj	335	9	virus	virus	NN
cord-260476-whfyczcj	336	1	The	the	DT
cord-260476-whfyczcj	336	2	E6	E6	NNP
cord-260476-whfyczcj	336	3	oncoprotein	oncoprotein	NN
cord-260476-whfyczcj	336	4	encoded	encode	VBN
cord-260476-whfyczcj	336	5	by	by	IN
cord-260476-whfyczcj	336	6	human	human	JJ
cord-260476-whfyczcj	336	7	papillomavirus	papillomavirus	NN
cord-260476-whfyczcj	336	8	types	type	NNS
cord-260476-whfyczcj	336	9	16	16	CD
cord-260476-whfyczcj	336	10	and	and	CC
cord-260476-whfyczcj	336	11	18	18	CD
cord-260476-whfyczcj	336	12	promotes	promote	VBZ
cord-260476-whfyczcj	336	13	the	the	DT
cord-260476-whfyczcj	336	14	degradation	degradation	NN
cord-260476-whfyczcj	336	15	of	of	IN
cord-260476-whfyczcj	336	16	p53	p53	NN
cord-260476-whfyczcj	337	1	The	the	DT
cord-260476-whfyczcj	337	2	HPV-16	HPV-16	NNP
cord-260476-whfyczcj	337	3	E6	E6	NNP
cord-260476-whfyczcj	337	4	and	and	CC
cord-260476-whfyczcj	337	5	E6-AP	e6-ap	JJ
cord-260476-whfyczcj	337	6	complex	complex	JJ
cord-260476-whfyczcj	337	7	functions	function	NNS
cord-260476-whfyczcj	337	8	as	as	IN
cord-260476-whfyczcj	337	9	a	a	DT
cord-260476-whfyczcj	337	10	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	337	11	-	-	HYPH
cord-260476-whfyczcj	337	12	protein	protein	NN
cord-260476-whfyczcj	337	13	ligase	ligase	NN
cord-260476-whfyczcj	337	14	in	in	IN
cord-260476-whfyczcj	337	15	the	the	DT
cord-260476-whfyczcj	337	16	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	337	17	of	of	IN
cord-260476-whfyczcj	337	18	p53	p53	NN
cord-260476-whfyczcj	337	19	Rotavirus	Rotavirus	NNP
cord-260476-whfyczcj	337	20	NSP1	NSP1	NNP
cord-260476-whfyczcj	337	21	inhibits	inhibit	VBZ
cord-260476-whfyczcj	337	22	NFκB	NFκB	NNP
cord-260476-whfyczcj	337	23	activation	activation	NN
cord-260476-whfyczcj	337	24	by	by	IN
cord-260476-whfyczcj	337	25	inducing	induce	VBG
cord-260476-whfyczcj	337	26	proteasome	proteasome	VBN
cord-260476-whfyczcj	337	27	-	-	HYPH
cord-260476-whfyczcj	337	28	dependent	dependent	JJ
cord-260476-whfyczcj	337	29	degradation	degradation	NN
cord-260476-whfyczcj	337	30	of	of	IN
cord-260476-whfyczcj	337	31	β	β	NN
cord-260476-whfyczcj	337	32	-	-	HYPH
cord-260476-whfyczcj	337	33	TrCP	TrCP	NNP
cord-260476-whfyczcj	337	34	:	:	:
cord-260476-whfyczcj	338	1	A	a	DT
cord-260476-whfyczcj	338	2	novel	novel	JJ
cord-260476-whfyczcj	338	3	mechanism	mechanism	NN
cord-260476-whfyczcj	338	4	of	of	IN
cord-260476-whfyczcj	338	5	IFN	IFN	NNP
cord-260476-whfyczcj	338	6	antagonism	antagonism	NN
cord-260476-whfyczcj	338	7	Putative	putative	JJ
cord-260476-whfyczcj	338	8	E3	E3	NNP
cord-260476-whfyczcj	338	9	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	338	10	ligase	ligase	NN
cord-260476-whfyczcj	338	11	of	of	IN
cord-260476-whfyczcj	338	12	human	human	JJ
cord-260476-whfyczcj	338	13	rotavirus	rotavirus	NN
cord-260476-whfyczcj	338	14	inhibits	inhibit	VBZ
cord-260476-whfyczcj	338	15	NF	nf	NN
cord-260476-whfyczcj	338	16	-	-	HYPH
cord-260476-whfyczcj	338	17	κB	κb	CD
cord-260476-whfyczcj	338	18	activation	activation	NN
cord-260476-whfyczcj	338	19	by	by	IN
cord-260476-whfyczcj	338	20	using	use	VBG
cord-260476-whfyczcj	338	21	molecular	molecular	JJ
cord-260476-whfyczcj	338	22	mimicry	mimicry	NN
cord-260476-whfyczcj	338	23	to	to	IN
cord-260476-whfyczcj	338	24	Target	Target	NNP
cord-260476-whfyczcj	338	25	β	β	NNP
cord-260476-whfyczcj	338	26	-	-	HYPH
cord-260476-whfyczcj	338	27	TrCP	TrCP	NNP
cord-260476-whfyczcj	338	28	Downregulation	Downregulation	NNP
cord-260476-whfyczcj	338	29	of	of	IN
cord-260476-whfyczcj	338	30	major	major	JJ
cord-260476-whfyczcj	338	31	histocompatibility	histocompatibility	NN
cord-260476-whfyczcj	338	32	complex	complex	JJ
cord-260476-whfyczcj	338	33	class	class	NN
cord-260476-whfyczcj	339	1	I	-PRON-	PRP
cord-260476-whfyczcj	339	2	molecules	molecule	NNS
cord-260476-whfyczcj	339	3	by	by	IN
cord-260476-whfyczcj	339	4	Kaposi	Kaposi	NNP
cord-260476-whfyczcj	339	5	's	's	POS
cord-260476-whfyczcj	339	6	sarcoma	sarcoma	NN
cord-260476-whfyczcj	339	7	-	-	HYPH
cord-260476-whfyczcj	339	8	associated	associate	VBN
cord-260476-whfyczcj	339	9	herpesvirus	herpesvirus	NN
cord-260476-whfyczcj	339	10	K3	K3	NNP
cord-260476-whfyczcj	339	11	and	and	CC
cord-260476-whfyczcj	339	12	K5	K5	NNP
cord-260476-whfyczcj	339	13	proteins	protein	NNS
cord-260476-whfyczcj	340	1	Kaposi	Kaposi	NNP
cord-260476-whfyczcj	340	2	's	's	POS
cord-260476-whfyczcj	340	3	sarcoma	sarcoma	NN
cord-260476-whfyczcj	340	4	-	-	HYPH
cord-260476-whfyczcj	340	5	associated	associate	VBN
cord-260476-whfyczcj	340	6	herpesvirus	herpesvirus	NN
cord-260476-whfyczcj	340	7	K3	K3	NNP
cord-260476-whfyczcj	340	8	utilizes	utilize	VBZ
cord-260476-whfyczcj	340	9	the	the	DT
cord-260476-whfyczcj	340	10	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	340	11	-	-	HYPH
cord-260476-whfyczcj	340	12	proteasome	proteasome	VBN
cord-260476-whfyczcj	340	13	system	system	NN
cord-260476-whfyczcj	340	14	in	in	IN
cord-260476-whfyczcj	340	15	routing	route	VBG
cord-260476-whfyczcj	340	16	class	class	NN
cord-260476-whfyczcj	340	17	major	major	JJ
cord-260476-whfyczcj	340	18	histocompatibility	histocompatibility	NN
cord-260476-whfyczcj	340	19	complexes	complex	NNS
cord-260476-whfyczcj	340	20	to	to	IN
cord-260476-whfyczcj	340	21	late	late	JJ
cord-260476-whfyczcj	340	22	endocytic	endocytic	JJ
cord-260476-whfyczcj	340	23	compartments	compartment	NNS
cord-260476-whfyczcj	340	24	Herpes	Herpes	NNP
cord-260476-whfyczcj	340	25	virus	virus	NN
cord-260476-whfyczcj	340	26	induced	induce	VBN
cord-260476-whfyczcj	340	27	proteasome	proteasome	NN
cord-260476-whfyczcj	340	28	-	-	HYPH
cord-260476-whfyczcj	340	29	dependent	dependent	JJ
cord-260476-whfyczcj	340	30	degradation	degradation	NN
cord-260476-whfyczcj	340	31	of	of	IN
cord-260476-whfyczcj	340	32	the	the	DT
cord-260476-whfyczcj	340	33	nuclear	nuclear	JJ
cord-260476-whfyczcj	340	34	bodies	body	NNS
cord-260476-whfyczcj	340	35	-	-	,
cord-260476-whfyczcj	340	36	associated	associate	VBN
cord-260476-whfyczcj	340	37	PML	PML	NNP
cord-260476-whfyczcj	340	38	and	and	CC
cord-260476-whfyczcj	340	39	Sp100	Sp100	NNP
cord-260476-whfyczcj	340	40	proteins	protein	NNS
cord-260476-whfyczcj	340	41	PML	PML	NNP
cord-260476-whfyczcj	340	42	contributes	contribute	VBZ
cord-260476-whfyczcj	340	43	to	to	IN
cord-260476-whfyczcj	340	44	a	a	DT
cord-260476-whfyczcj	340	45	cellular	cellular	JJ
cord-260476-whfyczcj	340	46	mechanism	mechanism	NN
cord-260476-whfyczcj	340	47	of	of	IN
cord-260476-whfyczcj	340	48	repression	repression	NN
cord-260476-whfyczcj	340	49	of	of	IN
cord-260476-whfyczcj	340	50	herpes	herpes	NNP
cord-260476-whfyczcj	340	51	simplex	simplex	NNP
cord-260476-whfyczcj	340	52	virus	virus	NN
cord-260476-whfyczcj	340	53	type	type	NN
cord-260476-whfyczcj	340	54	1	1	CD
cord-260476-whfyczcj	340	55	infection	infection	NN
cord-260476-whfyczcj	340	56	that	that	WDT
cord-260476-whfyczcj	340	57	is	be	VBZ
cord-260476-whfyczcj	340	58	inactivated	inactivate	VBN
cord-260476-whfyczcj	340	59	by	by	IN
cord-260476-whfyczcj	340	60	ICP0	ICP0	NNP
cord-260476-whfyczcj	340	61	Inhibitors	Inhibitors	NNP
cord-260476-whfyczcj	340	62	of	of	IN
cord-260476-whfyczcj	340	63	deubiquitinating	deubiquitinating	NN
cord-260476-whfyczcj	340	64	enzymes	enzyme	NNS
cord-260476-whfyczcj	340	65	block	block	VBP
cord-260476-whfyczcj	340	66	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	340	67	replication	replication	NN
cord-260476-whfyczcj	340	68	and	and	CC
cord-260476-whfyczcj	340	69	augment	augment	VB
cord-260476-whfyczcj	340	70	the	the	DT
cord-260476-whfyczcj	340	71	presentation	presentation	NN
cord-260476-whfyczcj	340	72	of	of	IN
cord-260476-whfyczcj	340	73	Gag	gag	NN
cord-260476-whfyczcj	340	74	-	-	HYPH
cord-260476-whfyczcj	340	75	derived	derive	VBN
cord-260476-whfyczcj	340	76	MHC	MHC	NNP
cord-260476-whfyczcj	340	77	-	-	HYPH
cord-260476-whfyczcj	340	78	I	-PRON-	PRP
cord-260476-whfyczcj	340	79	epitopes	epitope	NNS
cord-260476-whfyczcj	341	1	Proteasome	proteasome	NN
cord-260476-whfyczcj	341	2	inhibition	inhibition	NN
cord-260476-whfyczcj	341	3	interferes	interfere	VBZ
cord-260476-whfyczcj	341	4	with	with	IN
cord-260476-whfyczcj	341	5	gag	gag	NN
cord-260476-whfyczcj	341	6	polyprotein	polyprotein	JJ
cord-260476-whfyczcj	341	7	processing	processing	NN
cord-260476-whfyczcj	341	8	,	,	,
cord-260476-whfyczcj	341	9	release	release	NN
cord-260476-whfyczcj	341	10	,	,	,
cord-260476-whfyczcj	341	11	and	and	CC
cord-260476-whfyczcj	341	12	maturation	maturation	NN
cord-260476-whfyczcj	341	13	of	of	IN
cord-260476-whfyczcj	341	14	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	341	15	and	and	CC
cord-260476-whfyczcj	341	16	HIV-2	HIV-2	NNP
cord-260476-whfyczcj	341	17	Retroviruses	retrovirus	NNS
cord-260476-whfyczcj	342	1	have	have	VBP
cord-260476-whfyczcj	342	2	differing	differ	VBG
cord-260476-whfyczcj	342	3	requirements	requirement	NNS
cord-260476-whfyczcj	342	4	for	for	IN
cord-260476-whfyczcj	342	5	proteasome	proteasome	JJ
cord-260476-whfyczcj	342	6	function	function	NN
cord-260476-whfyczcj	342	7	in	in	IN
cord-260476-whfyczcj	342	8	the	the	DT
cord-260476-whfyczcj	342	9	budding	budding	NN
cord-260476-whfyczcj	342	10	process	process	NN
cord-260476-whfyczcj	343	1	Proteasome	Proteasome	NNP
cord-260476-whfyczcj	343	2	inhibitors	inhibitor	NNS
cord-260476-whfyczcj	343	3	block	block	VBP
cord-260476-whfyczcj	343	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	343	5	replication	replication	NN
cord-260476-whfyczcj	343	6	by	by	IN
cord-260476-whfyczcj	343	7	affecting	affect	VBG
cord-260476-whfyczcj	343	8	both	both	DT
cord-260476-whfyczcj	343	9	cellular	cellular	JJ
cord-260476-whfyczcj	343	10	and	and	CC
cord-260476-whfyczcj	343	11	viral	viral	JJ
cord-260476-whfyczcj	343	12	targets	target	NNS
cord-260476-whfyczcj	343	13	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	343	14	:	:	:
cord-260476-whfyczcj	344	1	Fifteen	fifteen	CD
cord-260476-whfyczcj	344	2	proteins	protein	NNS
cord-260476-whfyczcj	344	3	and	and	CC
cord-260476-whfyczcj	344	4	an	an	DT
cord-260476-whfyczcj	344	5	RNA	RNA	NNP
cord-260476-whfyczcj	344	6	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	344	7	replication	replication	NN
cord-260476-whfyczcj	344	8	HIV	HIV	NNP
cord-260476-whfyczcj	344	9	interaction	interaction	NN
cord-260476-whfyczcj	344	10	with	with	IN
cord-260476-whfyczcj	344	11	human	human	JJ
cord-260476-whfyczcj	344	12	host	host	NN
cord-260476-whfyczcj	344	13	:	:	:
cord-260476-whfyczcj	344	14	HIV-2	hiv-2	VB
cord-260476-whfyczcj	344	15	as	as	IN
cord-260476-whfyczcj	344	16	a	a	DT
cord-260476-whfyczcj	344	17	model	model	NN
cord-260476-whfyczcj	344	18	of	of	IN
cord-260476-whfyczcj	344	19	a	a	DT
cord-260476-whfyczcj	344	20	less	less	RBR
cord-260476-whfyczcj	344	21	virulent	virulent	JJ
cord-260476-whfyczcj	344	22	infection	infection	NN
cord-260476-whfyczcj	344	23	On	on	IN
cord-260476-whfyczcj	344	24	the	the	DT
cord-260476-whfyczcj	344	25	whereabouts	whereabouts	NN
cord-260476-whfyczcj	344	26	of	of	IN
cord-260476-whfyczcj	344	27	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	344	28	cellular	cellular	JJ
cord-260476-whfyczcj	344	29	entry	entry	NN
cord-260476-whfyczcj	344	30	and	and	CC
cord-260476-whfyczcj	344	31	its	-PRON-	PRP$
cord-260476-whfyczcj	344	32	fusion	fusion	NN
cord-260476-whfyczcj	344	33	ports	port	NNS
cord-260476-whfyczcj	344	34	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	344	35	reverse	reverse	VBP
cord-260476-whfyczcj	344	36	transcription	transcription	NN
cord-260476-whfyczcj	344	37	HIV	HIV	NNP
cord-260476-whfyczcj	344	38	DNA	DNA	NNP
cord-260476-whfyczcj	344	39	integration	integration	NN
cord-260476-whfyczcj	344	40	.	.	.
cord-260476-whfyczcj	345	1	Cold	Cold	NNP
cord-260476-whfyczcj	345	2	Spring	Spring	NNP
cord-260476-whfyczcj	345	3	Harb	Harb	NNP
cord-260476-whfyczcj	345	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	345	5	assembly	assembly	NN
cord-260476-whfyczcj	345	6	,	,	,
cord-260476-whfyczcj	345	7	budding	budding	NN
cord-260476-whfyczcj	345	8	,	,	,
cord-260476-whfyczcj	345	9	and	and	CC
cord-260476-whfyczcj	345	10	maturation	maturation	NN
cord-260476-whfyczcj	345	11	.	.	.
cord-260476-whfyczcj	346	1	Cold	Cold	NNP
cord-260476-whfyczcj	346	2	Spring	Spring	NNP
cord-260476-whfyczcj	346	3	Harb	Harb	NNP
cord-260476-whfyczcj	347	1	SERINC3	SERINC3	NNS
cord-260476-whfyczcj	347	2	and	and	CC
cord-260476-whfyczcj	347	3	SERINC5	serinc5	RB
cord-260476-whfyczcj	347	4	restrict	restrict	VB
cord-260476-whfyczcj	347	5	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	347	6	infectivity	infectivity	NN
cord-260476-whfyczcj	347	7	and	and	CC
cord-260476-whfyczcj	347	8	are	be	VBP
cord-260476-whfyczcj	347	9	counteracted	counteract	VBN
cord-260476-whfyczcj	347	10	by	by	IN
cord-260476-whfyczcj	347	11	Nef	Nef	NNP
cord-260476-whfyczcj	347	12	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	347	13	Nef	Nef	NNP
cord-260476-whfyczcj	347	14	promotes	promote	VBZ
cord-260476-whfyczcj	347	15	infection	infection	NN
cord-260476-whfyczcj	347	16	by	by	IN
cord-260476-whfyczcj	347	17	excluding	exclude	VBG
cord-260476-whfyczcj	347	18	SERINC5	serinc5	RB
cord-260476-whfyczcj	347	19	from	from	IN
cord-260476-whfyczcj	347	20	virion	virion	NN
cord-260476-whfyczcj	347	21	incorporation	incorporation	NN
cord-260476-whfyczcj	347	22	IFITM	IFITM	NNP
cord-260476-whfyczcj	347	23	proteins	protein	NNS
cord-260476-whfyczcj	347	24	incorporated	incorporate	VBN
cord-260476-whfyczcj	347	25	into	into	IN
cord-260476-whfyczcj	347	26	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	347	27	virions	virion	NNS
cord-260476-whfyczcj	347	28	impair	impair	VBP
cord-260476-whfyczcj	347	29	viral	viral	JJ
cord-260476-whfyczcj	347	30	fusion	fusion	NN
cord-260476-whfyczcj	347	31	and	and	CC
cord-260476-whfyczcj	347	32	spread	spread	VBD
cord-260476-whfyczcj	347	33	The	the	DT
cord-260476-whfyczcj	347	34	IFITM	IFITM	NNP
cord-260476-whfyczcj	347	35	proteins	protein	NNS
cord-260476-whfyczcj	348	1	inhibit	inhibit	VB
cord-260476-whfyczcj	348	2	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	348	3	infection	infection	NN
cord-260476-whfyczcj	349	1	The	the	DT
cord-260476-whfyczcj	349	2	V3	V3	NNP
cord-260476-whfyczcj	349	3	loop	loop	NN
cord-260476-whfyczcj	349	4	of	of	IN
cord-260476-whfyczcj	349	5	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	349	6	Env	Env	NNP
cord-260476-whfyczcj	349	7	determines	determine	VBZ
cord-260476-whfyczcj	349	8	viral	viral	JJ
cord-260476-whfyczcj	349	9	susceptibility	susceptibility	NN
cord-260476-whfyczcj	349	10	to	to	IN
cord-260476-whfyczcj	349	11	IFITM3	IFITM3	NNP
cord-260476-whfyczcj	349	12	impairment	impairment	NN
cord-260476-whfyczcj	349	13	of	of	IN
cord-260476-whfyczcj	349	14	viral	viral	JJ
cord-260476-whfyczcj	349	15	infectivity	infectivity	NN
cord-260476-whfyczcj	349	16	IFITM	IFITM	NNP
cord-260476-whfyczcj	349	17	proteins	protein	NNS
cord-260476-whfyczcj	349	18	are	be	VBP
cord-260476-whfyczcj	349	19	incorporated	incorporate	VBN
cord-260476-whfyczcj	349	20	onto	onto	IN
cord-260476-whfyczcj	349	21	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	349	22	virion	virion	NN
cord-260476-whfyczcj	349	23	particles	particle	NNS
cord-260476-whfyczcj	349	24	and	and	CC
cord-260476-whfyczcj	349	25	negatively	negatively	RB
cord-260476-whfyczcj	349	26	imprint	imprint	VB
cord-260476-whfyczcj	349	27	their	-PRON-	PRP$
cord-260476-whfyczcj	349	28	infectivity	infectivity	NN
cord-260476-whfyczcj	349	29	IFITM	IFITM	NNP
cord-260476-whfyczcj	349	30	proteins	protein	NNS
cord-260476-whfyczcj	349	31	restrict	restrict	VBP
cord-260476-whfyczcj	349	32	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	349	33	infection	infection	NN
cord-260476-whfyczcj	349	34	by	by	IN
cord-260476-whfyczcj	349	35	antagonizing	antagonize	VBG
cord-260476-whfyczcj	349	36	the	the	DT
cord-260476-whfyczcj	349	37	envelope	envelope	NN
cord-260476-whfyczcj	349	38	glycoprotein	glycoprotein	NN
cord-260476-whfyczcj	349	39	Resistance	resistance	NN
cord-260476-whfyczcj	349	40	of	of	IN
cord-260476-whfyczcj	349	41	transmitted	transmit	VBN
cord-260476-whfyczcj	349	42	founder	founder	NN
cord-260476-whfyczcj	349	43	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	349	44	to	to	IN
cord-260476-whfyczcj	350	1	IFITM	ifitm	NN
cord-260476-whfyczcj	350	2	-	-	HYPH
cord-260476-whfyczcj	350	3	mediated	mediate	VBN
cord-260476-whfyczcj	350	4	restriction	restriction	NN
cord-260476-whfyczcj	350	5	RING	ring	NN
cord-260476-whfyczcj	350	6	domain	domain	NN
cord-260476-whfyczcj	350	7	mutations	mutation	NNS
cord-260476-whfyczcj	350	8	uncouple	uncouple	VBP
cord-260476-whfyczcj	350	9	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	350	10	restriction	restriction	NN
cord-260476-whfyczcj	350	11	of	of	IN
cord-260476-whfyczcj	350	12	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	350	13	from	from	IN
cord-260476-whfyczcj	350	14	inhibition	inhibition	NN
cord-260476-whfyczcj	350	15	of	of	IN
cord-260476-whfyczcj	350	16	reverse	reverse	JJ
cord-260476-whfyczcj	350	17	transcription	transcription	NN
cord-260476-whfyczcj	350	18	and	and	CC
cord-260476-whfyczcj	350	19	acceleration	acceleration	NN
cord-260476-whfyczcj	350	20	of	of	IN
cord-260476-whfyczcj	350	21	uncoating	uncoate	VBG
cord-260476-whfyczcj	350	22	Specific	specific	JJ
cord-260476-whfyczcj	350	23	recognition	recognition	NN
cord-260476-whfyczcj	350	24	and	and	CC
cord-260476-whfyczcj	350	25	accelerated	accelerated	JJ
cord-260476-whfyczcj	350	26	uncoating	uncoating	NN
cord-260476-whfyczcj	350	27	of	of	IN
cord-260476-whfyczcj	350	28	retroviral	retroviral	JJ
cord-260476-whfyczcj	350	29	capsids	capsid	NNS
cord-260476-whfyczcj	350	30	by	by	IN
cord-260476-whfyczcj	350	31	the	the	DT
cord-260476-whfyczcj	350	32	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	350	33	restriction	restriction	NN
cord-260476-whfyczcj	350	34	factor	factor	NN
cord-260476-whfyczcj	350	35	The	the	DT
cord-260476-whfyczcj	350	36	cytoplasmic	cytoplasmic	JJ
cord-260476-whfyczcj	350	37	body	body	NN
cord-260476-whfyczcj	350	38	component	component	NN
cord-260476-whfyczcj	351	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	351	2	restricts	restrict	VBZ
cord-260476-whfyczcj	351	3	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	351	4	infection	infection	NN
cord-260476-whfyczcj	351	5	in	in	IN
cord-260476-whfyczcj	351	6	old	old	JJ
cord-260476-whfyczcj	351	7	world	world	NN
cord-260476-whfyczcj	351	8	monkeys	monkey	NNS
cord-260476-whfyczcj	351	9	MX2	MX2	NNP
cord-260476-whfyczcj	351	10	is	be	VBZ
cord-260476-whfyczcj	351	11	an	an	DT
cord-260476-whfyczcj	351	12	interferon	interferon	NN
cord-260476-whfyczcj	351	13	-	-	HYPH
cord-260476-whfyczcj	351	14	induced	induce	VBN
cord-260476-whfyczcj	351	15	inhibitor	inhibitor	NN
cord-260476-whfyczcj	351	16	of	of	IN
cord-260476-whfyczcj	351	17	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	351	18	infection	infection	NN
cord-260476-whfyczcj	351	19	Human	Human	NNP
cord-260476-whfyczcj	351	20	MX2	MX2	NNP
cord-260476-whfyczcj	352	1	is	be	VBZ
cord-260476-whfyczcj	352	2	an	an	DT
cord-260476-whfyczcj	352	3	interferon	interferon	NN
cord-260476-whfyczcj	352	4	-	-	HYPH
cord-260476-whfyczcj	352	5	induced	induce	VBN
cord-260476-whfyczcj	352	6	post	post	JJ
cord-260476-whfyczcj	352	7	-	-	JJ
cord-260476-whfyczcj	352	8	entry	entry	JJ
cord-260476-whfyczcj	352	9	inhibitor	inhibitor	NN
cord-260476-whfyczcj	352	10	of	of	IN
cord-260476-whfyczcj	352	11	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	352	12	infection	infection	NN
cord-260476-whfyczcj	352	13	Restriction	Restriction	NNP
cord-260476-whfyczcj	352	14	of	of	IN
cord-260476-whfyczcj	352	15	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	353	1	requires	require	VBZ
cord-260476-whfyczcj	353	2	the	the	DT
cord-260476-whfyczcj	353	3	N	n	CD
cord-260476-whfyczcj	353	4	-	-	HYPH
cord-260476-whfyczcj	353	5	terminal	terminal	NN
cord-260476-whfyczcj	353	6	region	region	NN
cord-260476-whfyczcj	353	7	of	of	IN
cord-260476-whfyczcj	353	8	MxB	MxB	NNP
cord-260476-whfyczcj	353	9	as	as	IN
cord-260476-whfyczcj	353	10	a	a	DT
cord-260476-whfyczcj	353	11	capsid	capsid	RB
cord-260476-whfyczcj	353	12	-	-	HYPH
cord-260476-whfyczcj	353	13	binding	bind	VBG
cord-260476-whfyczcj	353	14	motif	motif	NN
cord-260476-whfyczcj	353	15	but	but	CC
cord-260476-whfyczcj	353	16	not	not	RB
cord-260476-whfyczcj	353	17	as	as	IN
cord-260476-whfyczcj	353	18	a	a	DT
cord-260476-whfyczcj	353	19	nuclear	nuclear	JJ
cord-260476-whfyczcj	353	20	localization	localization	NN
cord-260476-whfyczcj	353	21	signal	signal	NN
cord-260476-whfyczcj	354	1	The	the	DT
cord-260476-whfyczcj	354	2	highly	highly	RB
cord-260476-whfyczcj	354	3	polymorphic	polymorphic	JJ
cord-260476-whfyczcj	354	4	cyclophilin	cyclophilin	NN
cord-260476-whfyczcj	354	5	A	a	NN
cord-260476-whfyczcj	354	6	-	-	HYPH
cord-260476-whfyczcj	354	7	binding	bind	VBG
cord-260476-whfyczcj	354	8	loop	loop	NN
cord-260476-whfyczcj	354	9	in	in	IN
cord-260476-whfyczcj	354	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	354	11	capsid	capsid	NN
cord-260476-whfyczcj	354	12	modulates	modulate	VBZ
cord-260476-whfyczcj	354	13	viral	viral	JJ
cord-260476-whfyczcj	354	14	resistance	resistance	NN
cord-260476-whfyczcj	354	15	to	to	IN
cord-260476-whfyczcj	354	16	MxB	MxB	NNP
cord-260476-whfyczcj	354	17	Host	Host	NNP
cord-260476-whfyczcj	354	18	and	and	CC
cord-260476-whfyczcj	354	19	viral	viral	JJ
cord-260476-whfyczcj	354	20	determinants	determinant	NNS
cord-260476-whfyczcj	354	21	of	of	IN
cord-260476-whfyczcj	354	22	Mx2	mx2	CD
cord-260476-whfyczcj	354	23	antiretroviral	antiretroviral	NNP
cord-260476-whfyczcj	354	24	activity	activity	NNP
cord-260476-whfyczcj	354	25	Host	Host	NNP
cord-260476-whfyczcj	354	26	and	and	CC
cord-260476-whfyczcj	354	27	viral	viral	JJ
cord-260476-whfyczcj	354	28	determinants	determinant	NNS
cord-260476-whfyczcj	354	29	for	for	IN
cord-260476-whfyczcj	354	30	MxB	mxb	JJ
cord-260476-whfyczcj	354	31	restriction	restriction	NN
cord-260476-whfyczcj	354	32	of	of	IN
cord-260476-whfyczcj	354	33	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	354	34	infection	infection	NN
cord-260476-whfyczcj	354	35	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	355	1	is	be	VBZ
cord-260476-whfyczcj	355	2	the	the	DT
cord-260476-whfyczcj	355	3	dendritic	dendritic	NN
cord-260476-whfyczcj	355	4	-	-	HYPH
cord-260476-whfyczcj	355	5	and	and	CC
cord-260476-whfyczcj	355	6	myeloid	myeloid	JJ
cord-260476-whfyczcj	355	7	-	-	HYPH
cord-260476-whfyczcj	355	8	cell	cell	NN
cord-260476-whfyczcj	355	9	-	-	HYPH
cord-260476-whfyczcj	355	10	specific	specific	JJ
cord-260476-whfyczcj	355	11	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	355	12	restriction	restriction	NN
cord-260476-whfyczcj	355	13	factor	factor	NN
cord-260476-whfyczcj	355	14	counteracted	counteract	VBN
cord-260476-whfyczcj	355	15	by	by	IN
cord-260476-whfyczcj	355	16	Vpx	Vpx	NNP
cord-260476-whfyczcj	355	17	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	355	18	restricts	restrict	VBZ
cord-260476-whfyczcj	355	19	the	the	DT
cord-260476-whfyczcj	355	20	replication	replication	NN
cord-260476-whfyczcj	355	21	of	of	IN
cord-260476-whfyczcj	355	22	human	human	JJ
cord-260476-whfyczcj	355	23	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	355	24	virus	virus	NN
cord-260476-whfyczcj	355	25	type	type	NN
cord-260476-whfyczcj	355	26	1	1	CD
cord-260476-whfyczcj	355	27	by	by	IN
cord-260476-whfyczcj	355	28	depleting	deplete	VBG
cord-260476-whfyczcj	355	29	the	the	DT
cord-260476-whfyczcj	355	30	intracellular	intracellular	JJ
cord-260476-whfyczcj	355	31	pool	pool	NN
cord-260476-whfyczcj	355	32	of	of	IN
cord-260476-whfyczcj	355	33	deoxynucleoside	deoxynucleoside	NNP
cord-260476-whfyczcj	355	34	triphosphates	triphosphates	NNP
cord-260476-whfyczcj	355	35	Isolation	Isolation	NNP
cord-260476-whfyczcj	355	36	of	of	IN
cord-260476-whfyczcj	355	37	a	a	DT
cord-260476-whfyczcj	355	38	human	human	JJ
cord-260476-whfyczcj	355	39	gene	gene	NN
cord-260476-whfyczcj	355	40	that	that	WDT
cord-260476-whfyczcj	355	41	inhibits	inhibit	VBZ
cord-260476-whfyczcj	355	42	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	355	43	infection	infection	NN
cord-260476-whfyczcj	355	44	and	and	CC
cord-260476-whfyczcj	355	45	is	be	VBZ
cord-260476-whfyczcj	355	46	suppressed	suppress	VBN
cord-260476-whfyczcj	355	47	by	by	IN
cord-260476-whfyczcj	355	48	the	the	DT
cord-260476-whfyczcj	355	49	viral	viral	JJ
cord-260476-whfyczcj	355	50	Vif	Vif	NNP
cord-260476-whfyczcj	355	51	protein	protein	NN
cord-260476-whfyczcj	356	1	The	the	DT
cord-260476-whfyczcj	356	2	cytidine	cytidine	NN
cord-260476-whfyczcj	356	3	deaminase	deaminase	NN
cord-260476-whfyczcj	356	4	CEM15	CEM15	NNP
cord-260476-whfyczcj	356	5	induces	induce	VBZ
cord-260476-whfyczcj	356	6	hypermutation	hypermutation	NN
cord-260476-whfyczcj	356	7	in	in	IN
cord-260476-whfyczcj	356	8	newly	newly	RB
cord-260476-whfyczcj	356	9	synthesized	synthesize	VBN
cord-260476-whfyczcj	356	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	356	11	DNA	DNA	NNP
cord-260476-whfyczcj	356	12	Broad	Broad	NNP
cord-260476-whfyczcj	356	13	antiretroviral	antiretroviral	JJ
cord-260476-whfyczcj	356	14	defence	defence	NN
cord-260476-whfyczcj	356	15	by	by	IN
cord-260476-whfyczcj	356	16	human	human	JJ
cord-260476-whfyczcj	356	17	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	356	18	G	g	NN
cord-260476-whfyczcj	356	19	through	through	IN
cord-260476-whfyczcj	356	20	lethal	lethal	JJ
cord-260476-whfyczcj	356	21	editing	editing	NN
cord-260476-whfyczcj	356	22	of	of	IN
cord-260476-whfyczcj	356	23	nascent	nascent	JJ
cord-260476-whfyczcj	356	24	reverse	reverse	NN
cord-260476-whfyczcj	356	25	transcripts	transcript	NNS
cord-260476-whfyczcj	356	26	Codon	codon	NN
cord-260476-whfyczcj	356	27	-	-	HYPH
cord-260476-whfyczcj	356	28	usage	usage	NN
cord-260476-whfyczcj	356	29	-	-	HYPH
cord-260476-whfyczcj	356	30	based	base	VBN
cord-260476-whfyczcj	356	31	inhibition	inhibition	NN
cord-260476-whfyczcj	356	32	of	of	IN
cord-260476-whfyczcj	356	33	HIV	HIV	NNP
cord-260476-whfyczcj	356	34	protein	protein	NN
cord-260476-whfyczcj	356	35	synthesis	synthesis	NN
cord-260476-whfyczcj	356	36	by	by	IN
cord-260476-whfyczcj	356	37	human	human	JJ
cord-260476-whfyczcj	356	38	schlafen	schlafen	NNP
cord-260476-whfyczcj	356	39	11	11	CD
cord-260476-whfyczcj	356	40	Non	non	JJ
cord-260476-whfyczcj	356	41	-	-	JJ
cord-260476-whfyczcj	356	42	human	human	JJ
cord-260476-whfyczcj	356	43	primate	primate	NN
cord-260476-whfyczcj	356	44	schlafen11	schlafen11	NN
cord-260476-whfyczcj	356	45	inhibits	inhibit	VBZ
cord-260476-whfyczcj	356	46	production	production	NN
cord-260476-whfyczcj	356	47	of	of	IN
cord-260476-whfyczcj	356	48	both	both	DT
cord-260476-whfyczcj	356	49	host	host	NN
cord-260476-whfyczcj	356	50	and	and	CC
cord-260476-whfyczcj	356	51	viral	viral	JJ
cord-260476-whfyczcj	356	52	proteins	protein	NNS
cord-260476-whfyczcj	356	53	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	356	54	modulates	modulate	VBZ
cord-260476-whfyczcj	356	55	the	the	DT
cord-260476-whfyczcj	356	56	tRNA	tRNA	NNP
cord-260476-whfyczcj	356	57	pool	pool	NN
cord-260476-whfyczcj	356	58	to	to	TO
cord-260476-whfyczcj	356	59	improve	improve	VB
cord-260476-whfyczcj	356	60	translation	translation	NN
cord-260476-whfyczcj	356	61	efficiency	efficiency	NN
cord-260476-whfyczcj	356	62	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	356	63	Vpu	Vpu	NNP
cord-260476-whfyczcj	356	64	promotes	promote	VBZ
cord-260476-whfyczcj	356	65	release	release	NN
cord-260476-whfyczcj	356	66	and	and	CC
cord-260476-whfyczcj	356	67	prevents	prevent	VBZ
cord-260476-whfyczcj	356	68	endocytosis	endocytosis	NN
cord-260476-whfyczcj	356	69	of	of	IN
cord-260476-whfyczcj	356	70	nascent	nascent	JJ
cord-260476-whfyczcj	356	71	retrovirus	retrovirus	NN
cord-260476-whfyczcj	356	72	particles	particle	NNS
cord-260476-whfyczcj	356	73	from	from	IN
cord-260476-whfyczcj	356	74	the	the	DT
cord-260476-whfyczcj	356	75	plasma	plasma	NN
cord-260476-whfyczcj	356	76	membrane	membrane	NN
cord-260476-whfyczcj	357	1	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	357	2	inhibits	inhibit	VBZ
cord-260476-whfyczcj	357	3	retrovirus	retrovirus	NN
cord-260476-whfyczcj	357	4	release	release	NN
cord-260476-whfyczcj	357	5	and	and	CC
cord-260476-whfyczcj	357	6	is	be	VBZ
cord-260476-whfyczcj	357	7	antagonized	antagonize	VBN
cord-260476-whfyczcj	357	8	by	by	IN
cord-260476-whfyczcj	358	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	358	2	Vpu	Vpu	NNP
cord-260476-whfyczcj	358	3	The	the	DT
cord-260476-whfyczcj	358	4	interferon	interferon	NN
cord-260476-whfyczcj	358	5	-	-	HYPH
cord-260476-whfyczcj	358	6	induced	induce	VBN
cord-260476-whfyczcj	358	7	protein	protein	NN
cord-260476-whfyczcj	358	8	BST-2	BST-2	NNP
cord-260476-whfyczcj	358	9	restricts	restrict	VBZ
cord-260476-whfyczcj	358	10	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	358	11	release	release	NN
cord-260476-whfyczcj	358	12	and	and	CC
cord-260476-whfyczcj	358	13	is	be	VBZ
cord-260476-whfyczcj	358	14	downregulated	downregulate	VBN
cord-260476-whfyczcj	358	15	from	from	IN
cord-260476-whfyczcj	358	16	the	the	DT
cord-260476-whfyczcj	358	17	cell	cell	NN
cord-260476-whfyczcj	358	18	surface	surface	NN
cord-260476-whfyczcj	358	19	by	by	IN
cord-260476-whfyczcj	358	20	the	the	DT
cord-260476-whfyczcj	358	21	viral	viral	JJ
cord-260476-whfyczcj	358	22	Vpu	Vpu	NNP
cord-260476-whfyczcj	358	23	protein	protein	NN
cord-260476-whfyczcj	358	24	MARCH8	march8	NN
cord-260476-whfyczcj	358	25	inhibits	inhibit	VBZ
cord-260476-whfyczcj	358	26	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	358	27	infection	infection	NN
cord-260476-whfyczcj	358	28	by	by	IN
cord-260476-whfyczcj	358	29	reducing	reduce	VBG
cord-260476-whfyczcj	358	30	virion	virion	NN
cord-260476-whfyczcj	358	31	incorporation	incorporation	NN
cord-260476-whfyczcj	358	32	of	of	IN
cord-260476-whfyczcj	358	33	envelope	envelope	NN
cord-260476-whfyczcj	358	34	glycoproteins	glycoprotein	NNS
cord-260476-whfyczcj	359	1	The	the	DT
cord-260476-whfyczcj	359	2	antagonism	antagonism	NN
cord-260476-whfyczcj	359	3	of	of	IN
cord-260476-whfyczcj	359	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	359	5	Nef	Nef	NNP
cord-260476-whfyczcj	359	6	to	to	TO
cord-260476-whfyczcj	359	7	SERINC5	serinc5	RB
cord-260476-whfyczcj	359	8	particle	particle	NN
cord-260476-whfyczcj	359	9	infectivity	infectivity	NN
cord-260476-whfyczcj	359	10	restriction	restriction	NN
cord-260476-whfyczcj	359	11	involves	involve	VBZ
cord-260476-whfyczcj	359	12	the	the	DT
cord-260476-whfyczcj	359	13	counteraction	counteraction	NN
cord-260476-whfyczcj	359	14	of	of	IN
cord-260476-whfyczcj	359	15	virion	virion	NN
cord-260476-whfyczcj	359	16	-	-	HYPH
cord-260476-whfyczcj	359	17	associated	associate	VBN
cord-260476-whfyczcj	359	18	pools	pool	NNS
cord-260476-whfyczcj	359	19	of	of	IN
cord-260476-whfyczcj	359	20	the	the	DT
cord-260476-whfyczcj	359	21	restriction	restriction	NN
cord-260476-whfyczcj	359	22	factor	factor	NN
cord-260476-whfyczcj	360	1	The	the	DT
cord-260476-whfyczcj	360	2	antiretroviral	antiretroviral	JJ
cord-260476-whfyczcj	360	3	enzyme	enzyme	NN
cord-260476-whfyczcj	360	4	APOBEC3	apobec3	NN
cord-260476-whfyczcj	360	5	G	g	NN
cord-260476-whfyczcj	360	6	is	be	VBZ
cord-260476-whfyczcj	360	7	degraded	degrade	VBN
cord-260476-whfyczcj	360	8	by	by	IN
cord-260476-whfyczcj	360	9	the	the	DT
cord-260476-whfyczcj	360	10	proteasome	proteasome	NN
cord-260476-whfyczcj	360	11	in	in	IN
cord-260476-whfyczcj	360	12	response	response	NN
cord-260476-whfyczcj	360	13	to	to	IN
cord-260476-whfyczcj	360	14	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	360	15	Vif	Vif	NNP
cord-260476-whfyczcj	360	16	Transcriptional	Transcriptional	NNP
cord-260476-whfyczcj	360	17	regulation	regulation	NN
cord-260476-whfyczcj	360	18	of	of	IN
cord-260476-whfyczcj	360	19	APOBEC3	apobec3	DT
cord-260476-whfyczcj	360	20	antiviral	antiviral	JJ
cord-260476-whfyczcj	360	21	immunity	immunity	NN
cord-260476-whfyczcj	360	22	through	through	IN
cord-260476-whfyczcj	360	23	the	the	DT
cord-260476-whfyczcj	360	24	CBF	CBF	NNP
cord-260476-whfyczcj	360	25	-	-	HYPH
cord-260476-whfyczcj	360	26	β	β	NNP
cord-260476-whfyczcj	360	27	/	/	SYM
cord-260476-whfyczcj	360	28	RUNX	RUNX	NNP
cord-260476-whfyczcj	360	29	axis	axis	NN
cord-260476-whfyczcj	361	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	361	2	Vif	Vif	NNP
cord-260476-whfyczcj	361	3	blocks	block	VBZ
cord-260476-whfyczcj	361	4	the	the	DT
cord-260476-whfyczcj	361	5	antiviral	antiviral	JJ
cord-260476-whfyczcj	361	6	activity	activity	NN
cord-260476-whfyczcj	361	7	of	of	IN
cord-260476-whfyczcj	361	8	APOBEC3	apobec3	DT
cord-260476-whfyczcj	361	9	G	g	NN
cord-260476-whfyczcj	361	10	by	by	IN
cord-260476-whfyczcj	361	11	impairing	impair	VBG
cord-260476-whfyczcj	361	12	both	both	CC
cord-260476-whfyczcj	361	13	its	-PRON-	PRP$
cord-260476-whfyczcj	361	14	translation	translation	NN
cord-260476-whfyczcj	361	15	and	and	CC
cord-260476-whfyczcj	361	16	intracellular	intracellular	JJ
cord-260476-whfyczcj	361	17	stability	stability	NN
cord-260476-whfyczcj	362	1	Vpx	Vpx	NNP
cord-260476-whfyczcj	362	2	relieves	relieve	VBZ
cord-260476-whfyczcj	362	3	inhibition	inhibition	NN
cord-260476-whfyczcj	362	4	of	of	IN
cord-260476-whfyczcj	362	5	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	362	6	infection	infection	NN
cord-260476-whfyczcj	362	7	of	of	IN
cord-260476-whfyczcj	362	8	macrophages	macrophage	NNS
cord-260476-whfyczcj	362	9	mediated	mediate	VBN
cord-260476-whfyczcj	362	10	by	by	IN
cord-260476-whfyczcj	362	11	the	the	DT
cord-260476-whfyczcj	362	12	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	362	13	protein	protein	NN
cord-260476-whfyczcj	363	1	The	the	DT
cord-260476-whfyczcj	363	2	ability	ability	NN
cord-260476-whfyczcj	363	3	of	of	IN
cord-260476-whfyczcj	363	4	primate	primate	JJ
cord-260476-whfyczcj	363	5	lentiviruses	lentiviruse	NNS
cord-260476-whfyczcj	363	6	to	to	TO
cord-260476-whfyczcj	363	7	degrade	degrade	VB
cord-260476-whfyczcj	363	8	the	the	DT
cord-260476-whfyczcj	363	9	monocyte	monocyte	NNP
cord-260476-whfyczcj	363	10	restriction	restriction	NN
cord-260476-whfyczcj	363	11	factor	factor	NN
cord-260476-whfyczcj	363	12	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	363	13	preceded	precede	VBD
cord-260476-whfyczcj	363	14	the	the	DT
cord-260476-whfyczcj	363	15	birth	birth	NN
cord-260476-whfyczcj	363	16	of	of	IN
cord-260476-whfyczcj	363	17	the	the	DT
cord-260476-whfyczcj	363	18	viral	viral	JJ
cord-260476-whfyczcj	363	19	accessory	accessory	NN
cord-260476-whfyczcj	363	20	protein	protein	NN
cord-260476-whfyczcj	363	21	Vpx	Vpx	NNP
cord-260476-whfyczcj	363	22	Vpu	Vpu	NNP
cord-260476-whfyczcj	363	23	binds	bind	VBZ
cord-260476-whfyczcj	363	24	directly	directly	RB
cord-260476-whfyczcj	363	25	to	to	IN
cord-260476-whfyczcj	363	26	tetherin	tetherin	NNP
cord-260476-whfyczcj	363	27	and	and	CC
cord-260476-whfyczcj	363	28	displaces	displace	VBZ
cord-260476-whfyczcj	363	29	it	-PRON-	PRP
cord-260476-whfyczcj	363	30	from	from	IN
cord-260476-whfyczcj	363	31	nascent	nascent	JJ
cord-260476-whfyczcj	363	32	virions	virion	NNS
cord-260476-whfyczcj	363	33	Early	early	IN
cord-260476-whfyczcj	363	34	replication	replication	NN
cord-260476-whfyczcj	363	35	block	block	NN
cord-260476-whfyczcj	363	36	of	of	IN
cord-260476-whfyczcj	363	37	human	human	JJ
cord-260476-whfyczcj	363	38	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	363	39	virus	virus	NN
cord-260476-whfyczcj	363	40	type	type	NN
cord-260476-whfyczcj	363	41	1	1	CD
cord-260476-whfyczcj	363	42	in	in	IN
cord-260476-whfyczcj	363	43	monkey	monkey	NN
cord-260476-whfyczcj	363	44	cells	cell	NNS
cord-260476-whfyczcj	363	45	Restriction	Restriction	NNP
cord-260476-whfyczcj	363	46	of	of	IN
cord-260476-whfyczcj	363	47	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	363	48	(	(	-LRB-
cord-260476-whfyczcj	363	49	subtype	subtype	NN
cord-260476-whfyczcj	363	50	B	b	NN
cord-260476-whfyczcj	363	51	)	)	-RRB-
cord-260476-whfyczcj	363	52	replication	replication	NN
cord-260476-whfyczcj	363	53	at	at	IN
cord-260476-whfyczcj	363	54	the	the	DT
cord-260476-whfyczcj	363	55	entry	entry	NN
cord-260476-whfyczcj	363	56	step	step	NN
cord-260476-whfyczcj	363	57	in	in	IN
cord-260476-whfyczcj	363	58	rhesus	rhesus	NN
cord-260476-whfyczcj	363	59	macaque	macaque	NN
cord-260476-whfyczcj	363	60	cells	cell	NNS
cord-260476-whfyczcj	363	61	Recruitment	recruitment	NN
cord-260476-whfyczcj	363	62	and	and	CC
cord-260476-whfyczcj	363	63	dynamics	dynamic	NNS
cord-260476-whfyczcj	363	64	of	of	IN
cord-260476-whfyczcj	363	65	proteasome	proteasome	NNP
cord-260476-whfyczcj	363	66	association	association	NN
cord-260476-whfyczcj	363	67	with	with	IN
cord-260476-whfyczcj	363	68	rhTRIM5α	rhtrim5α	JJ
cord-260476-whfyczcj	363	69	cytoplasmic	cytoplasmic	JJ
cord-260476-whfyczcj	363	70	complexes	complex	NNS
cord-260476-whfyczcj	363	71	during	during	IN
cord-260476-whfyczcj	363	72	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	363	73	infection	infection	NN
cord-260476-whfyczcj	364	1	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	364	2	associates	associate	NNS
cord-260476-whfyczcj	364	3	with	with	IN
cord-260476-whfyczcj	364	4	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	364	5	subunits	subunit	NNS
cord-260476-whfyczcj	364	6	in	in	IN
cord-260476-whfyczcj	364	7	cells	cell	NNS
cord-260476-whfyczcj	364	8	while	while	IN
cord-260476-whfyczcj	364	9	in	in	IN
cord-260476-whfyczcj	364	10	complex	complex	NN
cord-260476-whfyczcj	364	11	with	with	IN
cord-260476-whfyczcj	365	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	365	2	virions	virion	NNS
cord-260476-whfyczcj	365	3	Proteasomal	Proteasomal	NNP
cord-260476-whfyczcj	365	4	degradation	degradation	NN
cord-260476-whfyczcj	365	5	of	of	IN
cord-260476-whfyczcj	365	6	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	365	7	during	during	IN
cord-260476-whfyczcj	365	8	retrovirus	retrovirus	NN
cord-260476-whfyczcj	365	9	restriction	restriction	NN
cord-260476-whfyczcj	365	10	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	365	11	-	-	HYPH
cord-260476-whfyczcj	365	12	mediated	mediate	VBN
cord-260476-whfyczcj	365	13	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	365	14	chain	chain	NN
cord-260476-whfyczcj	365	15	conjugation	conjugation	NN
cord-260476-whfyczcj	365	16	is	be	VBZ
cord-260476-whfyczcj	365	17	required	require	VBN
cord-260476-whfyczcj	365	18	for	for	IN
cord-260476-whfyczcj	365	19	inhibition	inhibition	NN
cord-260476-whfyczcj	365	20	of	of	IN
cord-260476-whfyczcj	365	21	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	365	22	reverse	reverse	VBP
cord-260476-whfyczcj	365	23	transcription	transcription	NN
cord-260476-whfyczcj	365	24	and	and	CC
cord-260476-whfyczcj	365	25	capsid	capsid	NN
cord-260476-whfyczcj	365	26	destabilization	destabilization	NN
cord-260476-whfyczcj	365	27	Fates	fate	NNS
cord-260476-whfyczcj	365	28	of	of	IN
cord-260476-whfyczcj	365	29	retroviral	retroviral	JJ
cord-260476-whfyczcj	365	30	core	core	NN
cord-260476-whfyczcj	365	31	components	component	NNS
cord-260476-whfyczcj	365	32	during	during	IN
cord-260476-whfyczcj	365	33	unrestricted	unrestricted	JJ
cord-260476-whfyczcj	365	34	and	and	CC
cord-260476-whfyczcj	365	35	TRIM5-restricted	trim5-restricted	JJ
cord-260476-whfyczcj	365	36	infection	infection	NN
cord-260476-whfyczcj	365	37	Proteasome	Proteasome	NNP
cord-260476-whfyczcj	365	38	inhibition	inhibition	NN
cord-260476-whfyczcj	366	1	reveals	reveal	VBZ
cord-260476-whfyczcj	366	2	that	that	IN
cord-260476-whfyczcj	366	3	a	a	DT
cord-260476-whfyczcj	366	4	functional	functional	JJ
cord-260476-whfyczcj	366	5	preintegration	preintegration	NN
cord-260476-whfyczcj	366	6	complex	complex	JJ
cord-260476-whfyczcj	366	7	intermediate	intermediate	NN
cord-260476-whfyczcj	366	8	can	can	MD
cord-260476-whfyczcj	366	9	be	be	VB
cord-260476-whfyczcj	366	10	generated	generate	VBN
cord-260476-whfyczcj	366	11	during	during	IN
cord-260476-whfyczcj	366	12	restriction	restriction	NN
cord-260476-whfyczcj	366	13	by	by	IN
cord-260476-whfyczcj	366	14	diverse	diverse	JJ
cord-260476-whfyczcj	366	15	TRIM5	trim5	NN
cord-260476-whfyczcj	366	16	proteins	protein	NNS
cord-260476-whfyczcj	367	1	an	an	DT
cord-260476-whfyczcj	367	2	innate	innate	JJ
cord-260476-whfyczcj	367	3	immune	immune	JJ
cord-260476-whfyczcj	367	4	sensor	sensor	NN
cord-260476-whfyczcj	367	5	for	for	IN
cord-260476-whfyczcj	367	6	the	the	DT
cord-260476-whfyczcj	367	7	retrovirus	retrovirus	NN
cord-260476-whfyczcj	367	8	capsid	capsid	NN
cord-260476-whfyczcj	367	9	lattice	lattice	NN
cord-260476-whfyczcj	367	10	RING	ring	NN
cord-260476-whfyczcj	367	11	dimerization	dimerization	NN
cord-260476-whfyczcj	367	12	links	link	VBZ
cord-260476-whfyczcj	367	13	higher	high	JJR
cord-260476-whfyczcj	367	14	-	-	HYPH
cord-260476-whfyczcj	367	15	order	order	NN
cord-260476-whfyczcj	367	16	assembly	assembly	NN
cord-260476-whfyczcj	367	17	of	of	IN
cord-260476-whfyczcj	367	18	TRIM5α	TRIM5α	NNP
cord-260476-whfyczcj	367	19	to	to	IN
cord-260476-whfyczcj	367	20	synthesis	synthesis	NN
cord-260476-whfyczcj	367	21	of	of	IN
cord-260476-whfyczcj	367	22	K63-linked	K63-linked	NNP
cord-260476-whfyczcj	367	23	polyubiquitin	polyubiquitin	NNP
cord-260476-whfyczcj	367	24	Inhibition	Inhibition	NNP
cord-260476-whfyczcj	367	25	of	of	IN
cord-260476-whfyczcj	367	26	MHC	MHC	NNP
cord-260476-whfyczcj	367	27	class	class	NN
cord-260476-whfyczcj	367	28	II	II	NNP
cord-260476-whfyczcj	367	29	expression	expression	NN
cord-260476-whfyczcj	367	30	and	and	CC
cord-260476-whfyczcj	367	31	immune	immune	JJ
cord-260476-whfyczcj	367	32	responses	response	NNS
cord-260476-whfyczcj	367	33	by	by	IN
cord-260476-whfyczcj	367	34	c	c	NNP
cord-260476-whfyczcj	367	35	-	-	HYPH
cord-260476-whfyczcj	367	36	MIR	MIR	NNP
cord-260476-whfyczcj	367	37	Ubiquitination	Ubiquitination	NNP
cord-260476-whfyczcj	367	38	by	by	IN
cord-260476-whfyczcj	367	39	the	the	DT
cord-260476-whfyczcj	367	40	membrane	membrane	NN
cord-260476-whfyczcj	367	41	-	-	HYPH
cord-260476-whfyczcj	367	42	associated	associate	VBN
cord-260476-whfyczcj	367	43	RING	ring	NN
cord-260476-whfyczcj	367	44	-	-	HYPH
cord-260476-whfyczcj	367	45	CH-8	ch-8	NN
cord-260476-whfyczcj	368	1	(	(	-LRB-
cord-260476-whfyczcj	368	2	MARCH-8	MARCH-8	NNP
cord-260476-whfyczcj	368	3	)	)	-RRB-
cord-260476-whfyczcj	368	4	ligase	ligase	NN
cord-260476-whfyczcj	368	5	controls	control	VBZ
cord-260476-whfyczcj	368	6	steady	steady	JJ
cord-260476-whfyczcj	368	7	-	-	HYPH
cord-260476-whfyczcj	368	8	state	state	NN
cord-260476-whfyczcj	368	9	cell	cell	NN
cord-260476-whfyczcj	368	10	surface	surface	NN
cord-260476-whfyczcj	368	11	expression	expression	NN
cord-260476-whfyczcj	368	12	of	of	IN
cord-260476-whfyczcj	368	13	tumor	tumor	NN
cord-260476-whfyczcj	368	14	necrosis	necrosis	NN
cord-260476-whfyczcj	368	15	factor	factor	NN
cord-260476-whfyczcj	368	16	-	-	HYPH
cord-260476-whfyczcj	368	17	related	relate	VBN
cord-260476-whfyczcj	368	18	apoptosis	apoptosis	NN
cord-260476-whfyczcj	368	19	inducing	induce	VBG
cord-260476-whfyczcj	368	20	ligand	ligand	NN
cord-260476-whfyczcj	368	21	(	(	-LRB-
cord-260476-whfyczcj	368	22	TRAIL	TRAIL	NNP
cord-260476-whfyczcj	368	23	)	)	-RRB-
cord-260476-whfyczcj	368	24	receptor	receptor	NN
cord-260476-whfyczcj	368	25	1	1	CD
cord-260476-whfyczcj	369	1	The	the	DT
cord-260476-whfyczcj	369	2	E3	e3	NN
cord-260476-whfyczcj	369	3	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	369	4	ligase	ligase	NN
cord-260476-whfyczcj	369	5	MARCH8	MARCH8	NNP
cord-260476-whfyczcj	369	6	negatively	negatively	RB
cord-260476-whfyczcj	369	7	regulates	regulate	VBZ
cord-260476-whfyczcj	369	8	IL-1β	il-1β	NN
cord-260476-whfyczcj	369	9	-	-	HYPH
cord-260476-whfyczcj	369	10	induced	induce	VBN
cord-260476-whfyczcj	369	11	NF	nf	NN
cord-260476-whfyczcj	369	12	-	-	HYPH
cord-260476-whfyczcj	369	13	κB	κb	CD
cord-260476-whfyczcj	369	14	activation	activation	NN
cord-260476-whfyczcj	369	15	by	by	IN
cord-260476-whfyczcj	369	16	targeting	target	VBG
cord-260476-whfyczcj	369	17	the	the	DT
cord-260476-whfyczcj	369	18	IL1RAP	il1rap	NN
cord-260476-whfyczcj	369	19	coreceptor	coreceptor	NN
cord-260476-whfyczcj	369	20	for	for	IN
cord-260476-whfyczcj	369	21	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	369	22	and	and	CC
cord-260476-whfyczcj	369	23	degradation	degradation	NN
cord-260476-whfyczcj	369	24	MARCH	march	NN
cord-260476-whfyczcj	369	25	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	369	26	ligases	ligase	NNS
cord-260476-whfyczcj	370	1	alter	alter	VB
cord-260476-whfyczcj	370	2	the	the	DT
cord-260476-whfyczcj	370	3	itinerary	itinerary	NN
cord-260476-whfyczcj	370	4	of	of	IN
cord-260476-whfyczcj	370	5	clathrin	clathrin	NN
cord-260476-whfyczcj	370	6	-	-	HYPH
cord-260476-whfyczcj	370	7	independent	independent	JJ
cord-260476-whfyczcj	370	8	cargo	cargo	NN
cord-260476-whfyczcj	370	9	from	from	IN
cord-260476-whfyczcj	370	10	recycling	recycle	VBG
cord-260476-whfyczcj	370	11	to	to	IN
cord-260476-whfyczcj	370	12	degradation	degradation	NN
cord-260476-whfyczcj	370	13	Family	Family	NNP
cord-260476-whfyczcj	370	14	-	-	HYPH
cord-260476-whfyczcj	370	15	wide	wide	JJ
cord-260476-whfyczcj	370	16	comparative	comparative	JJ
cord-260476-whfyczcj	370	17	analysis	analysis	NN
cord-260476-whfyczcj	370	18	of	of	IN
cord-260476-whfyczcj	370	19	cytidine	cytidine	NNP
cord-260476-whfyczcj	370	20	and	and	CC
cord-260476-whfyczcj	370	21	methylcytidine	methylcytidine	NN
cord-260476-whfyczcj	370	22	deamination	deamination	NN
cord-260476-whfyczcj	370	23	by	by	IN
cord-260476-whfyczcj	370	24	eleven	eleven	CD
cord-260476-whfyczcj	370	25	human	human	JJ
cord-260476-whfyczcj	370	26	APOBEC	APOBEC	NNP
cord-260476-whfyczcj	370	27	proteins	protein	NNS
cord-260476-whfyczcj	371	1	APOBEC3F	APOBEC3F	NNP
cord-260476-whfyczcj	371	2	properties	property	NNS
cord-260476-whfyczcj	371	3	and	and	CC
cord-260476-whfyczcj	371	4	hypermutation	hypermutation	NN
cord-260476-whfyczcj	371	5	preferences	preference	NNS
cord-260476-whfyczcj	371	6	indicate	indicate	VBP
cord-260476-whfyczcj	371	7	activity	activity	NN
cord-260476-whfyczcj	371	8	against	against	IN
cord-260476-whfyczcj	371	9	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	372	1	In	in	IN
cord-260476-whfyczcj	372	2	Vivo	Vivo	NNP
cord-260476-whfyczcj	372	3	DNA	dna	NN
cord-260476-whfyczcj	372	4	deamination	deamination	NN
cord-260476-whfyczcj	372	5	mediates	mediate	VBZ
cord-260476-whfyczcj	372	6	innate	innate	JJ
cord-260476-whfyczcj	372	7	immunity	immunity	NN
cord-260476-whfyczcj	372	8	to	to	IN
cord-260476-whfyczcj	372	9	retroviral	retroviral	JJ
cord-260476-whfyczcj	372	10	infection	infection	NN
cord-260476-whfyczcj	372	11	Virion	virion	NN
cord-260476-whfyczcj	372	12	-	-	HYPH
cord-260476-whfyczcj	372	13	associated	associate	VBN
cord-260476-whfyczcj	372	14	uracil	uracil	NN
cord-260476-whfyczcj	372	15	DNA	DNA	NNP
cord-260476-whfyczcj	372	16	glycosylase-2	glycosylase-2	NNP
cord-260476-whfyczcj	372	17	and	and	CC
cord-260476-whfyczcj	373	1	apurinic	apurinic	NNP
cord-260476-whfyczcj	373	2	/	/	SYM
cord-260476-whfyczcj	373	3	apyrimidinic	apyrimidinic	NNP
cord-260476-whfyczcj	373	4	endonuclease	endonuclease	NN
cord-260476-whfyczcj	373	5	are	be	VBP
cord-260476-whfyczcj	373	6	involved	involve	VBN
cord-260476-whfyczcj	373	7	in	in	IN
cord-260476-whfyczcj	373	8	the	the	DT
cord-260476-whfyczcj	373	9	degradation	degradation	NN
cord-260476-whfyczcj	373	10	of	of	IN
cord-260476-whfyczcj	373	11	APOBEC3G	APOBEC3G	NNP
cord-260476-whfyczcj	373	12	-	-	HYPH
cord-260476-whfyczcj	373	13	edited	edit	VBN
cord-260476-whfyczcj	373	14	nascent	nascent	JJ
cord-260476-whfyczcj	373	15	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	373	16	DNA	DNA	NNP
cord-260476-whfyczcj	373	17	Induction	Induction	NNP
cord-260476-whfyczcj	373	18	of	of	IN
cord-260476-whfyczcj	373	19	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	374	1	G	g	NN
cord-260476-whfyczcj	374	2	ubiquitination	ubiquitination	NN
cord-260476-whfyczcj	374	3	and	and	CC
cord-260476-whfyczcj	374	4	degradation	degradation	NN
cord-260476-whfyczcj	374	5	by	by	IN
cord-260476-whfyczcj	374	6	an	an	DT
cord-260476-whfyczcj	374	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	374	8	Vif	Vif	NNP
cord-260476-whfyczcj	374	9	-	-	HYPH
cord-260476-whfyczcj	374	10	Cul5-SCF	Cul5-SCF	NNP
cord-260476-whfyczcj	374	11	complex	complex	JJ
cord-260476-whfyczcj	374	12	A	a	DT
cord-260476-whfyczcj	374	13	zinc	zinc	NN
cord-260476-whfyczcj	374	14	-	-	HYPH
cord-260476-whfyczcj	374	15	binding	bind	VBG
cord-260476-whfyczcj	374	16	region	region	NN
cord-260476-whfyczcj	374	17	in	in	IN
cord-260476-whfyczcj	374	18	Vif	Vif	NNP
cord-260476-whfyczcj	374	19	binds	bind	VBZ
cord-260476-whfyczcj	374	20	Cul5	Cul5	NNP
cord-260476-whfyczcj	374	21	and	and	CC
cord-260476-whfyczcj	374	22	determines	determine	VBZ
cord-260476-whfyczcj	374	23	cullin	cullin	NN
cord-260476-whfyczcj	374	24	selection	selection	NN
cord-260476-whfyczcj	374	25	Phosphorylation	Phosphorylation	NNP
cord-260476-whfyczcj	374	26	of	of	IN
cord-260476-whfyczcj	374	27	a	a	DT
cord-260476-whfyczcj	374	28	novel	novel	JJ
cord-260476-whfyczcj	374	29	SOCS	SOCS	NNP
cord-260476-whfyczcj	374	30	-	-	HYPH
cord-260476-whfyczcj	374	31	box	box	NNP
cord-260476-whfyczcj	374	32	regulates	regulate	VBZ
cord-260476-whfyczcj	374	33	assembly	assembly	NN
cord-260476-whfyczcj	374	34	of	of	IN
cord-260476-whfyczcj	374	35	the	the	DT
cord-260476-whfyczcj	374	36	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	374	37	Vif	Vif	NNP
cord-260476-whfyczcj	374	38	-	-	HYPH
cord-260476-whfyczcj	374	39	Cul5	Cul5	NNP
cord-260476-whfyczcj	374	40	complex	complex	NN
cord-260476-whfyczcj	374	41	that	that	WDT
cord-260476-whfyczcj	374	42	promotes	promote	VBZ
cord-260476-whfyczcj	374	43	APOBEC3	apobec3	DT
cord-260476-whfyczcj	374	44	G	g	NN
cord-260476-whfyczcj	374	45	degradation	degradation	NN
cord-260476-whfyczcj	375	1	The	the	DT
cord-260476-whfyczcj	375	2	HDAC6	HDAC6	NNS
cord-260476-whfyczcj	375	3	/	/	SYM
cord-260476-whfyczcj	375	4	APOBEC3	apobec3	NN
cord-260476-whfyczcj	375	5	G	G	NNP
cord-260476-whfyczcj	375	6	complex	complex	NN
cord-260476-whfyczcj	375	7	regulates	regulate	VBZ
cord-260476-whfyczcj	375	8	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	375	9	infectiveness	infectiveness	RBR
cord-260476-whfyczcj	375	10	by	by	IN
cord-260476-whfyczcj	375	11	inducing	induce	VBG
cord-260476-whfyczcj	375	12	Vif	Vif	NNP
cord-260476-whfyczcj	375	13	autophagic	autophagic	NNP
cord-260476-whfyczcj	375	14	degradation	degradation	NN
cord-260476-whfyczcj	375	15	MDM2	MDM2	NNP
cord-260476-whfyczcj	376	1	is	be	VBZ
cord-260476-whfyczcj	376	2	a	a	DT
cord-260476-whfyczcj	376	3	novel	novel	JJ
cord-260476-whfyczcj	376	4	E3	e3	NN
cord-260476-whfyczcj	376	5	ligase	ligase	NN
cord-260476-whfyczcj	376	6	for	for	IN
cord-260476-whfyczcj	376	7	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	376	8	Vif	Vif	NNP
cord-260476-whfyczcj	376	9	Core	Core	NNP
cord-260476-whfyczcj	376	10	binding	binding	NN
cord-260476-whfyczcj	376	11	factor	factor	NN
cord-260476-whfyczcj	376	12	β	β	NN
cord-260476-whfyczcj	376	13	protects	protect	VBZ
cord-260476-whfyczcj	376	14	HIV	HIV	NNP
cord-260476-whfyczcj	376	15	,	,	,
cord-260476-whfyczcj	376	16	type	type	NN
cord-260476-whfyczcj	376	17	1	1	CD
cord-260476-whfyczcj	376	18	accessory	accessory	NN
cord-260476-whfyczcj	376	19	protein	protein	NN
cord-260476-whfyczcj	376	20	viral	viral	JJ
cord-260476-whfyczcj	376	21	infectivity	infectivity	NN
cord-260476-whfyczcj	376	22	factor	factor	NN
cord-260476-whfyczcj	376	23	from	from	IN
cord-260476-whfyczcj	376	24	MDM2-mediated	mdm2-mediated	JJ
cord-260476-whfyczcj	376	25	degradation	degradation	NN
cord-260476-whfyczcj	376	26	Vif	Vif	NNP
cord-260476-whfyczcj	376	27	hijacks	hijack	VBZ
cord-260476-whfyczcj	376	28	CBF	CBF	NNP
cord-260476-whfyczcj	376	29	-	-	HYPH
cord-260476-whfyczcj	376	30	β	β	NN
cord-260476-whfyczcj	376	31	to	to	TO
cord-260476-whfyczcj	376	32	degrade	degrade	VB
cord-260476-whfyczcj	376	33	APOBEC3	apobec3	DT
cord-260476-whfyczcj	376	34	G	g	NN
cord-260476-whfyczcj	376	35	and	and	CC
cord-260476-whfyczcj	376	36	promote	promote	VB
cord-260476-whfyczcj	376	37	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	376	38	infection	infection	NN
cord-260476-whfyczcj	376	39	T	t	NN
cord-260476-whfyczcj	376	40	-	-	HYPH
cord-260476-whfyczcj	376	41	cell	cell	NN
cord-260476-whfyczcj	376	42	differentiation	differentiation	NN
cord-260476-whfyczcj	376	43	factor	factor	NN
cord-260476-whfyczcj	376	44	CBF	CBF	NNP
cord-260476-whfyczcj	376	45	-	-	HYPH
cord-260476-whfyczcj	376	46	β	β	NNP
cord-260476-whfyczcj	376	47	regulates	regulate	VBZ
cord-260476-whfyczcj	376	48	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	376	49	Vif	Vif	NNP
cord-260476-whfyczcj	376	50	-	-	HYPH
cord-260476-whfyczcj	376	51	mediated	mediate	VBN
cord-260476-whfyczcj	376	52	evasion	evasion	NN
cord-260476-whfyczcj	376	53	of	of	IN
cord-260476-whfyczcj	376	54	host	host	NN
cord-260476-whfyczcj	376	55	restriction	restriction	NN
cord-260476-whfyczcj	376	56	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	376	57	Vif	Vif	NNP
cord-260476-whfyczcj	376	58	binds	bind	VBZ
cord-260476-whfyczcj	376	59	to	to	IN
cord-260476-whfyczcj	376	60	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	376	61	G	G	NNP
cord-260476-whfyczcj	376	62	mRNA	mrna	NN
cord-260476-whfyczcj	376	63	and	and	CC
cord-260476-whfyczcj	376	64	inhibits	inhibit	VBZ
cord-260476-whfyczcj	376	65	its	-PRON-	PRP$
cord-260476-whfyczcj	376	66	translation	translation	NN
cord-260476-whfyczcj	376	67	Translational	translational	JJ
cord-260476-whfyczcj	376	68	regulation	regulation	NN
cord-260476-whfyczcj	376	69	of	of	IN
cord-260476-whfyczcj	376	70	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	376	71	G	g	NN
cord-260476-whfyczcj	376	72	mRNA	mrna	NN
cord-260476-whfyczcj	376	73	by	by	IN
cord-260476-whfyczcj	376	74	Vif	vif	NN
cord-260476-whfyczcj	377	1	requires	require	VBZ
cord-260476-whfyczcj	377	2	its	-PRON-	PRP$
cord-260476-whfyczcj	377	3	5'UTR	5'utr	CD
cord-260476-whfyczcj	377	4	and	and	CC
cord-260476-whfyczcj	377	5	contributes	contribute	VBZ
cord-260476-whfyczcj	377	6	to	to	IN
cord-260476-whfyczcj	377	7	restoring	restore	VBG
cord-260476-whfyczcj	377	8	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	377	9	infectivity	infectivity	NN
cord-260476-whfyczcj	377	10	Human	Human	NNP
cord-260476-whfyczcj	377	11	and	and	CC
cord-260476-whfyczcj	377	12	rhesus	rhesu	NNS
cord-260476-whfyczcj	377	13	APOBEC3D	APOBEC3D	NNP
cord-260476-whfyczcj	377	14	,	,	,
cord-260476-whfyczcj	377	15	APOBEC3F	APOBEC3F	NNP
cord-260476-whfyczcj	377	16	,	,	,
cord-260476-whfyczcj	377	17	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	377	18	G	g	NN
cord-260476-whfyczcj	377	19	,	,	,
cord-260476-whfyczcj	377	20	and	and	CC
cord-260476-whfyczcj	377	21	APOBEC3H	apobec3h	RB
cord-260476-whfyczcj	377	22	demonstrate	demonstrate	VB
cord-260476-whfyczcj	377	23	a	a	DT
cord-260476-whfyczcj	377	24	conserved	conserve	VBN
cord-260476-whfyczcj	377	25	capacity	capacity	NN
cord-260476-whfyczcj	377	26	to	to	TO
cord-260476-whfyczcj	377	27	restrict	restrict	VB
cord-260476-whfyczcj	377	28	Vif	vif	NN
cord-260476-whfyczcj	377	29	-	-	HYPH
cord-260476-whfyczcj	377	30	deficient	deficient	JJ
cord-260476-whfyczcj	377	31	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	378	1	The	the	DT
cord-260476-whfyczcj	378	2	activity	activity	NN
cord-260476-whfyczcj	378	3	spectrum	spectrum	NN
cord-260476-whfyczcj	378	4	of	of	IN
cord-260476-whfyczcj	378	5	Vif	Vif	NNP
cord-260476-whfyczcj	378	6	from	from	IN
cord-260476-whfyczcj	378	7	multiple	multiple	JJ
cord-260476-whfyczcj	378	8	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	378	9	subtypes	subtype	NNS
cord-260476-whfyczcj	378	10	against	against	IN
cord-260476-whfyczcj	378	11	APOBEC3	APOBEC3	NNP
cord-260476-whfyczcj	378	12	G	G	NNP
cord-260476-whfyczcj	378	13	,	,	,
cord-260476-whfyczcj	378	14	APOBEC3F	APOBEC3F	NNP
cord-260476-whfyczcj	378	15	,	,	,
cord-260476-whfyczcj	378	16	and	and	CC
cord-260476-whfyczcj	378	17	APOBEC3H	APOBEC3H	NNP
cord-260476-whfyczcj	378	18	Suppression	suppression	NN
cord-260476-whfyczcj	378	19	of	of	IN
cord-260476-whfyczcj	378	20	APOBEC3-mediated	APOBEC3-mediated	NNP
cord-260476-whfyczcj	378	21	restriction	restriction	NN
cord-260476-whfyczcj	378	22	of	of	IN
cord-260476-whfyczcj	378	23	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	378	24	by	by	IN
cord-260476-whfyczcj	378	25	Vif	Vif	NNP
cord-260476-whfyczcj	378	26	Regulation	Regulation	NNP
cord-260476-whfyczcj	378	27	of	of	IN
cord-260476-whfyczcj	378	28	Apobec3F	apobec3f	NN
cord-260476-whfyczcj	378	29	and	and	CC
cord-260476-whfyczcj	378	30	human	human	JJ
cord-260476-whfyczcj	378	31	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	378	32	virus	virus	NN
cord-260476-whfyczcj	378	33	type	type	NN
cord-260476-whfyczcj	378	34	1	1	CD
cord-260476-whfyczcj	378	35	Vif	vif	NN
cord-260476-whfyczcj	378	36	by	by	IN
cord-260476-whfyczcj	378	37	Vif	Vif	NNP
cord-260476-whfyczcj	378	38	-	-	HYPH
cord-260476-whfyczcj	378	39	Cul5-ElonB	Cul5-ElonB	NNP
cord-260476-whfyczcj	378	40	/	/	SYM
cord-260476-whfyczcj	378	41	C	c	NN
cord-260476-whfyczcj	378	42	E3	e3	NN
cord-260476-whfyczcj	378	43	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	378	44	ligase	ligase	NN
cord-260476-whfyczcj	378	45	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	378	46	restriction	restriction	NN
cord-260476-whfyczcj	378	47	factor	factor	NN
cord-260476-whfyczcj	379	1	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	379	2	is	be	VBZ
cord-260476-whfyczcj	379	3	a	a	DT
cord-260476-whfyczcj	379	4	deoxynucleoside	deoxynucleoside	JJ
cord-260476-whfyczcj	379	5	triphosphate	triphosphate	NN
cord-260476-whfyczcj	379	6	triphosphohydrolase	triphosphohydrolase	NNP
cord-260476-whfyczcj	379	7	Aicardi	Aicardi	NNPS
cord-260476-whfyczcj	379	8	-	-	HYPH
cord-260476-whfyczcj	379	9	goutieres	goutieres	NNP
cord-260476-whfyczcj	379	10	syndrome	syndrome	NN
cord-260476-whfyczcj	379	11	gene	gene	NN
cord-260476-whfyczcj	379	12	and	and	CC
cord-260476-whfyczcj	379	13	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	379	14	restriction	restriction	NN
cord-260476-whfyczcj	379	15	factor	factor	NN
cord-260476-whfyczcj	379	16	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	380	1	is	be	VBZ
cord-260476-whfyczcj	380	2	a	a	DT
cord-260476-whfyczcj	380	3	dGTP	dgtp	NN
cord-260476-whfyczcj	380	4	-	-	HYPH
cord-260476-whfyczcj	380	5	regulated	regulate	VBN
cord-260476-whfyczcj	380	6	deoxynucleotide	deoxynucleotide	NN
cord-260476-whfyczcj	380	7	triphosphohydrolase	triphosphohydrolase	NN
cord-260476-whfyczcj	380	8	Tight	tight	JJ
cord-260476-whfyczcj	380	9	interplay	interplay	NN
cord-260476-whfyczcj	380	10	among	among	IN
cord-260476-whfyczcj	380	11	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	380	12	protein	protein	NN
cord-260476-whfyczcj	380	13	level	level	NN
cord-260476-whfyczcj	380	14	,	,	,
cord-260476-whfyczcj	380	15	cellular	cellular	JJ
cord-260476-whfyczcj	380	16	dNTP	dNTP	NNP
cord-260476-whfyczcj	380	17	levels	level	NNS
cord-260476-whfyczcj	380	18	,	,	,
cord-260476-whfyczcj	380	19	and	and	CC
cord-260476-whfyczcj	380	20	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	380	21	proviral	proviral	JJ
cord-260476-whfyczcj	380	22	DNA	dna	NN
cord-260476-whfyczcj	380	23	synthesis	synthesis	NN
cord-260476-whfyczcj	380	24	kinetics	kinetic	NNS
cord-260476-whfyczcj	380	25	in	in	IN
cord-260476-whfyczcj	380	26	human	human	JJ
cord-260476-whfyczcj	380	27	primary	primary	JJ
cord-260476-whfyczcj	380	28	monocyte	monocyte	NNP
cord-260476-whfyczcj	380	29	-	-	HYPH
cord-260476-whfyczcj	380	30	derived	derive	VBN
cord-260476-whfyczcj	380	31	macrophages	macrophage	NNS
cord-260476-whfyczcj	381	1	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	381	2	restricts	restrict	VBZ
cord-260476-whfyczcj	381	3	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	381	4	infection	infection	NN
cord-260476-whfyczcj	381	5	in	in	IN
cord-260476-whfyczcj	381	6	resting	rest	VBG
cord-260476-whfyczcj	381	7	CD4(+	CD4(+	NNS
cord-260476-whfyczcj	381	8	)	)	-RRB-
cord-260476-whfyczcj	382	1	T	T	NNP
cord-260476-whfyczcj	382	2	cells	cell	NNS
cord-260476-whfyczcj	383	1	The	the	DT
cord-260476-whfyczcj	383	2	human	human	JJ
cord-260476-whfyczcj	383	3	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	383	4	virus	virus	NN
cord-260476-whfyczcj	383	5	type	type	NN
cord-260476-whfyczcj	384	1	2	2	LS
cord-260476-whfyczcj	384	2	Vpx	Vpx	NNP
cord-260476-whfyczcj	384	3	protein	protein	NN
cord-260476-whfyczcj	384	4	usurps	usurp	VBZ
cord-260476-whfyczcj	384	5	the	the	DT
cord-260476-whfyczcj	384	6	CUL4A	cul4a	NN
cord-260476-whfyczcj	384	7	-	-	HYPH
cord-260476-whfyczcj	384	8	DDB1	ddb1	NN
cord-260476-whfyczcj	384	9	DCAF1	dcaf1	NN
cord-260476-whfyczcj	384	10	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	384	11	ligase	ligase	NN
cord-260476-whfyczcj	384	12	to	to	TO
cord-260476-whfyczcj	384	13	overcome	overcome	VB
cord-260476-whfyczcj	384	14	a	a	DT
cord-260476-whfyczcj	384	15	postentry	postentry	NN
cord-260476-whfyczcj	384	16	block	block	NN
cord-260476-whfyczcj	384	17	in	in	IN
cord-260476-whfyczcj	384	18	macrophage	macrophage	NN
cord-260476-whfyczcj	384	19	infection	infection	NN
cord-260476-whfyczcj	384	20	Role	role	NN
cord-260476-whfyczcj	384	21	of	of	IN
cord-260476-whfyczcj	384	22	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	384	23	nuclear	nuclear	JJ
cord-260476-whfyczcj	384	24	localization	localization	NN
cord-260476-whfyczcj	384	25	in	in	IN
cord-260476-whfyczcj	384	26	restriction	restriction	NN
cord-260476-whfyczcj	384	27	of	of	IN
cord-260476-whfyczcj	384	28	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	384	29	and	and	CC
cord-260476-whfyczcj	384	30	SIVmac	SIVmac	NNP
cord-260476-whfyczcj	385	1	The	the	DT
cord-260476-whfyczcj	385	2	Vpx	Vpx	NNP
cord-260476-whfyczcj	385	3	lentiviral	lentiviral	JJ
cord-260476-whfyczcj	385	4	accessory	accessory	NN
cord-260476-whfyczcj	385	5	protein	protein	NN
cord-260476-whfyczcj	385	6	targets	target	NNS
cord-260476-whfyczcj	385	7	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	385	8	for	for	IN
cord-260476-whfyczcj	385	9	degradation	degradation	NN
cord-260476-whfyczcj	385	10	in	in	IN
cord-260476-whfyczcj	385	11	the	the	DT
cord-260476-whfyczcj	385	12	nucleus	nucleus	NN
cord-260476-whfyczcj	385	13	DDB1	DDB1	NNP
cord-260476-whfyczcj	385	14	and	and	CC
cord-260476-whfyczcj	385	15	Cul4A	cul4a	XX
cord-260476-whfyczcj	386	1	are	be	VBP
cord-260476-whfyczcj	386	2	required	require	VBN
cord-260476-whfyczcj	386	3	for	for	IN
cord-260476-whfyczcj	386	4	human	human	JJ
cord-260476-whfyczcj	386	5	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	386	6	virus	virus	NN
cord-260476-whfyczcj	386	7	type	type	NN
cord-260476-whfyczcj	386	8	1	1	CD
cord-260476-whfyczcj	386	9	Vpr	Vpr	NNP
cord-260476-whfyczcj	386	10	-	-	HYPH
cord-260476-whfyczcj	386	11	induced	induce	VBN
cord-260476-whfyczcj	386	12	G2	G2	NNP
cord-260476-whfyczcj	386	13	arrest	arrest	NN
cord-260476-whfyczcj	387	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	387	2	Vpr	Vpr	NNP
cord-260476-whfyczcj	387	3	-	-	HYPH
cord-260476-whfyczcj	387	4	mediated	mediate	VBN
cord-260476-whfyczcj	387	5	G2	G2	NNP
cord-260476-whfyczcj	387	6	arrest	arrest	NN
cord-260476-whfyczcj	387	7	involves	involve	VBZ
cord-260476-whfyczcj	387	8	the	the	DT
cord-260476-whfyczcj	387	9	DDB1-CUL4AVPRBP	DDB1-CUL4AVPRBP	NNP
cord-260476-whfyczcj	387	10	E3	E3	NNP
cord-260476-whfyczcj	387	11	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	387	12	ligase	ligase	NN
cord-260476-whfyczcj	388	1	Premature	premature	JJ
cord-260476-whfyczcj	388	2	activation	activation	NN
cord-260476-whfyczcj	388	3	of	of	IN
cord-260476-whfyczcj	388	4	the	the	DT
cord-260476-whfyczcj	388	5	SLX4	SLX4	NNP
cord-260476-whfyczcj	388	6	complex	complex	NN
cord-260476-whfyczcj	388	7	by	by	IN
cord-260476-whfyczcj	388	8	Vpr	Vpr	NNP
cord-260476-whfyczcj	388	9	promotes	promote	VBZ
cord-260476-whfyczcj	388	10	G2	G2	NNP
cord-260476-whfyczcj	388	11	/	/	SYM
cord-260476-whfyczcj	388	12	M	M	NNP
cord-260476-whfyczcj	388	13	arrest	arrest	NN
cord-260476-whfyczcj	388	14	and	and	CC
cord-260476-whfyczcj	388	15	escape	escape	VB
cord-260476-whfyczcj	388	16	from	from	IN
cord-260476-whfyczcj	388	17	innate	innate	JJ
cord-260476-whfyczcj	388	18	immune	immune	JJ
cord-260476-whfyczcj	388	19	sensing	sensing	NN
cord-260476-whfyczcj	388	20	SLX4-SLX1	SLX4-SLX1	NNP
cord-260476-whfyczcj	388	21	protein	protein	NN
cord-260476-whfyczcj	388	22	-	-	HYPH
cord-260476-whfyczcj	388	23	independent	independent	JJ
cord-260476-whfyczcj	388	24	down	down	JJ
cord-260476-whfyczcj	388	25	-	-	HYPH
cord-260476-whfyczcj	388	26	regulation	regulation	NN
cord-260476-whfyczcj	388	27	of	of	IN
cord-260476-whfyczcj	388	28	MUS81-EME1	mus81-eme1	JJ
cord-260476-whfyczcj	388	29	protein	protein	NN
cord-260476-whfyczcj	388	30	by	by	IN
cord-260476-whfyczcj	389	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	389	2	viral	viral	JJ
cord-260476-whfyczcj	389	3	protein	protein	NN
cord-260476-whfyczcj	389	4	R	r	NN
cord-260476-whfyczcj	389	5	(	(	-LRB-
cord-260476-whfyczcj	389	6	Vpr	Vpr	NNP
cord-260476-whfyczcj	389	7	)	)	-RRB-
cord-260476-whfyczcj	389	8	Complex	complex	JJ
cord-260476-whfyczcj	389	9	evolutionary	evolutionary	JJ
cord-260476-whfyczcj	389	10	history	history	NN
cord-260476-whfyczcj	389	11	of	of	IN
cord-260476-whfyczcj	389	12	primate	primate	JJ
cord-260476-whfyczcj	389	13	lentiviralvprgenes	lentiviralvprgene	NNS
cord-260476-whfyczcj	389	14	Evolutionary	Evolutionary	NNP
cord-260476-whfyczcj	389	15	toggling	toggle	VBG
cord-260476-whfyczcj	389	16	of	of	IN
cord-260476-whfyczcj	389	17	Vpx	Vpx	NNP
cord-260476-whfyczcj	389	18	/	/	SYM
cord-260476-whfyczcj	389	19	Vpr	Vpr	NNP
cord-260476-whfyczcj	389	20	specificity	specificity	NN
cord-260476-whfyczcj	389	21	results	result	NNS
cord-260476-whfyczcj	389	22	in	in	IN
cord-260476-whfyczcj	389	23	divergent	divergent	JJ
cord-260476-whfyczcj	389	24	recognition	recognition	NN
cord-260476-whfyczcj	389	25	of	of	IN
cord-260476-whfyczcj	389	26	the	the	DT
cord-260476-whfyczcj	389	27	restriction	restriction	NN
cord-260476-whfyczcj	389	28	factor	factor	NN
cord-260476-whfyczcj	390	1	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	391	1	Cell	cell	NN
cord-260476-whfyczcj	391	2	cycle	cycle	NN
cord-260476-whfyczcj	391	3	control	control	NN
cord-260476-whfyczcj	391	4	and	and	CC
cord-260476-whfyczcj	391	5	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	391	6	susceptibility	susceptibility	NN
cord-260476-whfyczcj	391	7	are	be	VBP
cord-260476-whfyczcj	391	8	linked	link	VBN
cord-260476-whfyczcj	391	9	by	by	IN
cord-260476-whfyczcj	391	10	CDK6-dependent	CDK6-dependent	NNP
cord-260476-whfyczcj	391	11	CDK2	CDK2	NNP
cord-260476-whfyczcj	391	12	phosphorylation	phosphorylation	NN
cord-260476-whfyczcj	391	13	of	of	IN
cord-260476-whfyczcj	391	14	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	391	15	in	in	IN
cord-260476-whfyczcj	391	16	myeloid	myeloid	JJ
cord-260476-whfyczcj	391	17	and	and	CC
cord-260476-whfyczcj	391	18	lymphoid	lymphoid	JJ
cord-260476-whfyczcj	391	19	cells	cell	NNS
cord-260476-whfyczcj	391	20	CD81	CD81	NNP
cord-260476-whfyczcj	391	21	association	association	NN
cord-260476-whfyczcj	391	22	with	with	IN
cord-260476-whfyczcj	391	23	SAMHD1	SAMHD1	NNPS
cord-260476-whfyczcj	391	24	enhances	enhance	VBZ
cord-260476-whfyczcj	391	25	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	391	26	reverse	reverse	NN
cord-260476-whfyczcj	391	27	transcription	transcription	NN
cord-260476-whfyczcj	391	28	by	by	IN
cord-260476-whfyczcj	391	29	increasing	increase	VBG
cord-260476-whfyczcj	391	30	dNTP	dNTP	NNP
cord-260476-whfyczcj	391	31	levels	level	NNS
cord-260476-whfyczcj	392	1	Cyclin	Cyclin	NNP
cord-260476-whfyczcj	392	2	L2	L2	NNP
cord-260476-whfyczcj	392	3	is	be	VBZ
cord-260476-whfyczcj	392	4	a	a	DT
cord-260476-whfyczcj	392	5	critical	critical	JJ
cord-260476-whfyczcj	392	6	HIV	HIV	NNP
cord-260476-whfyczcj	392	7	dependency	dependency	NN
cord-260476-whfyczcj	392	8	factor	factor	NN
cord-260476-whfyczcj	392	9	in	in	IN
cord-260476-whfyczcj	392	10	macrophages	macrophage	NNS
cord-260476-whfyczcj	392	11	that	that	WDT
cord-260476-whfyczcj	392	12	controls	control	VBZ
cord-260476-whfyczcj	392	13	SAMHD1	SAMHD1	VBZ
cord-260476-whfyczcj	392	14	abundance	abundance	NN
cord-260476-whfyczcj	393	1	Structural	structural	JJ
cord-260476-whfyczcj	393	2	basis	basis	NN
cord-260476-whfyczcj	393	3	of	of	IN
cord-260476-whfyczcj	393	4	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	393	5	tethering	tether	VBG
cord-260476-whfyczcj	393	6	to	to	IN
cord-260476-whfyczcj	393	7	membranes	membrane	NNS
cord-260476-whfyczcj	393	8	by	by	IN
cord-260476-whfyczcj	393	9	the	the	DT
cord-260476-whfyczcj	393	10	BST-2	BST-2	NNP
cord-260476-whfyczcj	393	11	/	/	SYM
cord-260476-whfyczcj	393	12	tetherin	tetherin	XX
cord-260476-whfyczcj	393	13	ectodomain	ectodomain	NNP
cord-260476-whfyczcj	393	14	Mechanism	Mechanism	NNP
cord-260476-whfyczcj	393	15	of	of	IN
cord-260476-whfyczcj	393	16	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	393	17	virion	virion	NN
cord-260476-whfyczcj	393	18	entrapment	entrapment	NN
cord-260476-whfyczcj	393	19	by	by	IN
cord-260476-whfyczcj	393	20	tetherin	tetherin	NNP
cord-260476-whfyczcj	393	21	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	393	22	Vpu	Vpu	NNP
cord-260476-whfyczcj	393	23	protein	protein	NN
cord-260476-whfyczcj	393	24	antagonizes	antagonize	VBZ
cord-260476-whfyczcj	393	25	innate	innate	JJ
cord-260476-whfyczcj	393	26	restriction	restriction	NN
cord-260476-whfyczcj	393	27	factor	factor	NN
cord-260476-whfyczcj	393	28	BST-2	BST-2	NNP
cord-260476-whfyczcj	393	29	via	via	IN
cord-260476-whfyczcj	394	1	lipid	lipid	NN
cord-260476-whfyczcj	394	2	-	-	HYPH
cord-260476-whfyczcj	394	3	embedded	embed	VBN
cord-260476-whfyczcj	394	4	helix	helix	NN
cord-260476-whfyczcj	394	5	-	-	HYPH
cord-260476-whfyczcj	394	6	helix	helix	NN
cord-260476-whfyczcj	394	7	interactions	interaction	NNS
cord-260476-whfyczcj	394	8	Vpu	Vpu	NNP
cord-260476-whfyczcj	394	9	antagonizes	antagonize	VBZ
cord-260476-whfyczcj	394	10	BST-2-mediated	bst-2-mediate	VBN
cord-260476-whfyczcj	394	11	restriction	restriction	NN
cord-260476-whfyczcj	394	12	of	of	IN
cord-260476-whfyczcj	394	13	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	394	14	release	release	VBP
cord-260476-whfyczcj	394	15	via	via	IN
cord-260476-whfyczcj	394	16	β	β	NN
cord-260476-whfyczcj	394	17	-	-	HYPH
cord-260476-whfyczcj	394	18	TrCP	trcp	NN
cord-260476-whfyczcj	394	19	and	and	CC
cord-260476-whfyczcj	394	20	endo	endo	NN
cord-260476-whfyczcj	394	21	-	-	HYPH
cord-260476-whfyczcj	394	22	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	394	23	trafficking	trafficking	NN
cord-260476-whfyczcj	394	24	Antagonism	antagonism	NN
cord-260476-whfyczcj	394	25	of	of	IN
cord-260476-whfyczcj	394	26	tetherin	tetherin	NN
cord-260476-whfyczcj	394	27	restriction	restriction	NN
cord-260476-whfyczcj	394	28	of	of	IN
cord-260476-whfyczcj	394	29	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	394	30	release	release	NN
cord-260476-whfyczcj	394	31	by	by	IN
cord-260476-whfyczcj	394	32	Vpu	Vpu	NNP
cord-260476-whfyczcj	394	33	involves	involve	VBZ
cord-260476-whfyczcj	394	34	binding	binding	NN
cord-260476-whfyczcj	394	35	and	and	CC
cord-260476-whfyczcj	394	36	sequestration	sequestration	NN
cord-260476-whfyczcj	394	37	of	of	IN
cord-260476-whfyczcj	394	38	the	the	DT
cord-260476-whfyczcj	394	39	restriction	restriction	NN
cord-260476-whfyczcj	394	40	factor	factor	NN
cord-260476-whfyczcj	394	41	in	in	IN
cord-260476-whfyczcj	394	42	a	a	DT
cord-260476-whfyczcj	394	43	perinuclear	perinuclear	JJ
cord-260476-whfyczcj	394	44	compartment	compartment	NN
cord-260476-whfyczcj	394	45	Characterization	characterization	NN
cord-260476-whfyczcj	394	46	of	of	IN
cord-260476-whfyczcj	394	47	E3	e3	NN
cord-260476-whfyczcj	394	48	ligases	ligase	NNS
cord-260476-whfyczcj	394	49	involved	involve	VBN
cord-260476-whfyczcj	394	50	in	in	IN
cord-260476-whfyczcj	394	51	lysosomal	lysosomal	JJ
cord-260476-whfyczcj	394	52	sorting	sorting	NN
cord-260476-whfyczcj	394	53	of	of	IN
cord-260476-whfyczcj	394	54	the	the	DT
cord-260476-whfyczcj	394	55	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	394	56	restriction	restriction	NN
cord-260476-whfyczcj	394	57	factor	factor	NN
cord-260476-whfyczcj	395	1	BST2	BST2	NNP
cord-260476-whfyczcj	396	1	A	a	DT
cord-260476-whfyczcj	396	2	novel	novel	JJ
cord-260476-whfyczcj	396	3	human	human	NN
cord-260476-whfyczcj	396	4	WD	WD	NNP
cord-260476-whfyczcj	396	5	protein	protein	NN
cord-260476-whfyczcj	396	6	,	,	,
cord-260476-whfyczcj	396	7	h	h	NNP
cord-260476-whfyczcj	396	8	-	-	HYPH
cord-260476-whfyczcj	396	9	β	β	NNP
cord-260476-whfyczcj	396	10	TrCp	TrCp	NNP
cord-260476-whfyczcj	396	11	,	,	,
cord-260476-whfyczcj	396	12	that	that	WDT
cord-260476-whfyczcj	396	13	interacts	interact	VBZ
cord-260476-whfyczcj	396	14	with	with	IN
cord-260476-whfyczcj	396	15	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	396	16	Vpu	Vpu	NNP
cord-260476-whfyczcj	396	17	connects	connect	VBZ
cord-260476-whfyczcj	396	18	CD4	CD4	NNP
cord-260476-whfyczcj	396	19	to	to	IN
cord-260476-whfyczcj	396	20	the	the	DT
cord-260476-whfyczcj	396	21	ER	ER	NNP
cord-260476-whfyczcj	396	22	degradation	degradation	NN
cord-260476-whfyczcj	396	23	pathway	pathway	NN
cord-260476-whfyczcj	396	24	through	through	IN
cord-260476-whfyczcj	396	25	an	an	DT
cord-260476-whfyczcj	396	26	F	F	NNP
cord-260476-whfyczcj	396	27	-	-	HYPH
cord-260476-whfyczcj	396	28	box	box	NN
cord-260476-whfyczcj	396	29	motif	motif	NN
cord-260476-whfyczcj	397	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	397	2	accessory	accessory	NN
cord-260476-whfyczcj	397	3	protein	protein	NN
cord-260476-whfyczcj	397	4	Vpu	Vpu	NNP
cord-260476-whfyczcj	397	5	internalizes	internalize	VBZ
cord-260476-whfyczcj	397	6	cell	cell	NN
cord-260476-whfyczcj	397	7	-	-	HYPH
cord-260476-whfyczcj	397	8	surface	surface	NN
cord-260476-whfyczcj	397	9	BST-2	BST-2	NNP
cord-260476-whfyczcj	397	10	/	/	SYM
cord-260476-whfyczcj	397	11	tetherin	tetherin	XX
cord-260476-whfyczcj	397	12	through	through	IN
cord-260476-whfyczcj	397	13	transmembrane	transmembrane	NN
cord-260476-whfyczcj	397	14	interactions	interaction	NNS
cord-260476-whfyczcj	397	15	leading	lead	VBG
cord-260476-whfyczcj	397	16	to	to	IN
cord-260476-whfyczcj	397	17	lysosomes	lysosomes	NNP
cord-260476-whfyczcj	397	18	Vpu	Vpu	NNP
cord-260476-whfyczcj	397	19	directs	direct	VBZ
cord-260476-whfyczcj	397	20	the	the	DT
cord-260476-whfyczcj	397	21	degradation	degradation	NN
cord-260476-whfyczcj	397	22	of	of	IN
cord-260476-whfyczcj	397	23	the	the	DT
cord-260476-whfyczcj	397	24	human	human	JJ
cord-260476-whfyczcj	397	25	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	397	26	virus	virus	NN
cord-260476-whfyczcj	397	27	restriction	restriction	NN
cord-260476-whfyczcj	397	28	factor	factor	NN
cord-260476-whfyczcj	397	29	BST-2	BST-2	NNP
cord-260476-whfyczcj	397	30	/	/	SYM
cord-260476-whfyczcj	397	31	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	397	32	via	via	IN
cord-260476-whfyczcj	397	33	a	a	DT
cord-260476-whfyczcj	397	34	{	{	-LRB-
cord-260476-whfyczcj	397	35	β}TrCP	β}trcp	NN
cord-260476-whfyczcj	397	36	-	-	HYPH
cord-260476-whfyczcj	397	37	dependent	dependent	JJ
cord-260476-whfyczcj	397	38	mechanism	mechanism	NN
cord-260476-whfyczcj	398	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	398	2	Vpu	Vpu	NNP
cord-260476-whfyczcj	398	3	neutralizes	neutralize	VBZ
cord-260476-whfyczcj	398	4	the	the	DT
cord-260476-whfyczcj	398	5	antiviral	antiviral	JJ
cord-260476-whfyczcj	398	6	factor	factor	NN
cord-260476-whfyczcj	398	7	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	398	8	/	/	SYM
cord-260476-whfyczcj	398	9	BST-2	BST-2	NNP
cord-260476-whfyczcj	398	10	by	by	IN
cord-260476-whfyczcj	398	11	binding	bind	VBG
cord-260476-whfyczcj	398	12	it	-PRON-	PRP
cord-260476-whfyczcj	398	13	and	and	CC
cord-260476-whfyczcj	398	14	directing	direct	VBG
cord-260476-whfyczcj	398	15	its	-PRON-	PRP$
cord-260476-whfyczcj	398	16	β	β	NN
cord-260476-whfyczcj	398	17	-	-	HYPH
cord-260476-whfyczcj	398	18	TrCP2-dependent	TrCP2-dependent	NNP
cord-260476-whfyczcj	398	19	degradation	degradation	NN
cord-260476-whfyczcj	398	20	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	398	21	Vpu	Vpu	NNP
cord-260476-whfyczcj	399	1	utilizes	utilize	VBZ
cord-260476-whfyczcj	399	2	both	both	CC
cord-260476-whfyczcj	399	3	cullin	cullin	NN
cord-260476-whfyczcj	399	4	-	-	HYPH
cord-260476-whfyczcj	399	5	RING	ring	NN
cord-260476-whfyczcj	399	6	ligase	ligase	NN
cord-260476-whfyczcj	399	7	(	(	-LRB-
cord-260476-whfyczcj	399	8	CRL	CRL	NNP
cord-260476-whfyczcj	399	9	)	)	-RRB-
cord-260476-whfyczcj	399	10	dependent	dependent	JJ
cord-260476-whfyczcj	399	11	and	and	CC
cord-260476-whfyczcj	399	12	independent	independent	JJ
cord-260476-whfyczcj	399	13	mechanisms	mechanism	NNS
cord-260476-whfyczcj	399	14	to	to	TO
cord-260476-whfyczcj	399	15	downmodulate	downmodulate	VB
cord-260476-whfyczcj	399	16	host	host	NN
cord-260476-whfyczcj	399	17	proteins	protein	NNS
cord-260476-whfyczcj	399	18	Serine	serine	JJ
cord-260476-whfyczcj	399	19	phosphorylation	phosphorylation	NN
cord-260476-whfyczcj	399	20	of	of	IN
cord-260476-whfyczcj	399	21	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	399	22	Vpu	Vpu	NNP
cord-260476-whfyczcj	399	23	and	and	CC
cord-260476-whfyczcj	399	24	its	-PRON-	PRP$
cord-260476-whfyczcj	399	25	binding	binding	NN
cord-260476-whfyczcj	399	26	to	to	IN
cord-260476-whfyczcj	399	27	tetherin	tetherin	NNP
cord-260476-whfyczcj	399	28	regulates	regulate	VBZ
cord-260476-whfyczcj	399	29	interaction	interaction	NN
cord-260476-whfyczcj	399	30	with	with	IN
cord-260476-whfyczcj	399	31	clathrin	clathrin	NN
cord-260476-whfyczcj	399	32	adaptors	adaptor	NNS
cord-260476-whfyczcj	399	33	β	β	NNP
cord-260476-whfyczcj	399	34	-	-	HYPH
cord-260476-whfyczcj	399	35	TrCP	TrCP	NNP
cord-260476-whfyczcj	399	36	is	be	VBZ
cord-260476-whfyczcj	399	37	dispensable	dispensable	JJ
cord-260476-whfyczcj	399	38	for	for	IN
cord-260476-whfyczcj	399	39	Vpu	Vpu	NNP
cord-260476-whfyczcj	399	40	's	's	POS
cord-260476-whfyczcj	399	41	ability	ability	NN
cord-260476-whfyczcj	399	42	to	to	TO
cord-260476-whfyczcj	399	43	overcome	overcome	VB
cord-260476-whfyczcj	399	44	the	the	DT
cord-260476-whfyczcj	399	45	CD317	CD317	NNP
cord-260476-whfyczcj	399	46	/	/	SYM
cord-260476-whfyczcj	399	47	Tetherin	tetherin	NN
cord-260476-whfyczcj	399	48	-	-	HYPH
cord-260476-whfyczcj	399	49	imposed	impose	VBN
cord-260476-whfyczcj	399	50	restriction	restriction	NN
cord-260476-whfyczcj	399	51	to	to	IN
cord-260476-whfyczcj	399	52	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	399	53	release	release	VB
cord-260476-whfyczcj	399	54	Berlioz	Berlioz	NNP
cord-260476-whfyczcj	399	55	-	-	HYPH
cord-260476-whfyczcj	399	56	Torrent	Torrent	NNP
cord-260476-whfyczcj	399	57	,	,	,
cord-260476-whfyczcj	399	58	C.	C.	NNP
cord-260476-whfyczcj	399	59	LC3C	LC3C	NNP
cord-260476-whfyczcj	399	60	contributes	contribute	VBZ
cord-260476-whfyczcj	399	61	to	to	IN
cord-260476-whfyczcj	399	62	Vpu	Vpu	NNP
cord-260476-whfyczcj	399	63	-	-	HYPH
cord-260476-whfyczcj	399	64	mediated	mediate	VBN
cord-260476-whfyczcj	399	65	antagonism	antagonism	NN
cord-260476-whfyczcj	399	66	of	of	IN
cord-260476-whfyczcj	399	67	BST2	BST2	NNP
cord-260476-whfyczcj	399	68	/	/	SYM
cord-260476-whfyczcj	399	69	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	399	70	restriction	restriction	NN
cord-260476-whfyczcj	399	71	on	on	IN
cord-260476-whfyczcj	399	72	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	399	73	release	release	VBP
cord-260476-whfyczcj	399	74	through	through	IN
cord-260476-whfyczcj	399	75	a	a	DT
cord-260476-whfyczcj	399	76	non	non	JJ
cord-260476-whfyczcj	399	77	-	-	JJ
cord-260476-whfyczcj	399	78	canonical	canonical	JJ
cord-260476-whfyczcj	399	79	autophagy	autophagy	NN
cord-260476-whfyczcj	399	80	pathway	pathway	NN
cord-260476-whfyczcj	399	81	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	399	82	Vpu	Vpu	NNP
cord-260476-whfyczcj	400	1	antagonizes	antagonize	VBZ
cord-260476-whfyczcj	400	2	CD317	CD317	NNP
cord-260476-whfyczcj	400	3	/	/	SYM
cord-260476-whfyczcj	400	4	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	400	5	by	by	IN
cord-260476-whfyczcj	400	6	adaptor	adaptor	NN
cord-260476-whfyczcj	400	7	protein-1-mediated	protein-1-mediated	JJ
cord-260476-whfyczcj	400	8	exclusion	exclusion	NN
cord-260476-whfyczcj	400	9	from	from	IN
cord-260476-whfyczcj	400	10	virus	virus	NN
cord-260476-whfyczcj	400	11	assembly	assembly	NN
cord-260476-whfyczcj	400	12	sites	site	NNS
cord-260476-whfyczcj	400	13	Berlioz	Berlioz	NNP
cord-260476-whfyczcj	400	14	-	-	HYPH
cord-260476-whfyczcj	400	15	Torrent	Torrent	NNP
cord-260476-whfyczcj	400	16	,	,	,
cord-260476-whfyczcj	400	17	C.	C.	NNP
cord-260476-whfyczcj	401	1	The	the	DT
cord-260476-whfyczcj	401	2	ESCRT-0	ESCRT-0	NNP
cord-260476-whfyczcj	401	3	component	component	NN
cord-260476-whfyczcj	401	4	HRS	HRS	NNP
cord-260476-whfyczcj	401	5	is	be	VBZ
cord-260476-whfyczcj	401	6	required	require	VBN
cord-260476-whfyczcj	401	7	for	for	IN
cord-260476-whfyczcj	401	8	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	401	9	Vpu	Vpu	NNP
cord-260476-whfyczcj	401	10	-	-	HYPH
cord-260476-whfyczcj	401	11	mediated	mediate	VBN
cord-260476-whfyczcj	401	12	BST-2	BST-2	NNP
cord-260476-whfyczcj	401	13	/	/	SYM
cord-260476-whfyczcj	401	14	tetherin	tetherin	VBP
cord-260476-whfyczcj	401	15	down	down	IN
cord-260476-whfyczcj	401	16	-	-	HYPH
cord-260476-whfyczcj	401	17	regulation	regulation	NN
cord-260476-whfyczcj	401	18	Guanylate	Guanylate	NNP
cord-260476-whfyczcj	401	19	binding	bind	VBG
cord-260476-whfyczcj	401	20	protein	protein	NN
cord-260476-whfyczcj	401	21	(	(	-LRB-
cord-260476-whfyczcj	401	22	GBP	GBP	NNP
cord-260476-whfyczcj	401	23	)	)	-RRB-
cord-260476-whfyczcj	401	24	5	5	CD
cord-260476-whfyczcj	401	25	is	be	VBZ
cord-260476-whfyczcj	401	26	an	an	DT
cord-260476-whfyczcj	401	27	interferon	interferon	NN
cord-260476-whfyczcj	401	28	-	-	HYPH
cord-260476-whfyczcj	401	29	inducible	inducible	JJ
cord-260476-whfyczcj	401	30	inhibitor	inhibitor	NN
cord-260476-whfyczcj	401	31	of	of	IN
cord-260476-whfyczcj	401	32	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	401	33	infectivity	infectivity	NN
cord-260476-whfyczcj	401	34	Identification	identification	NN
cord-260476-whfyczcj	401	35	of	of	IN
cord-260476-whfyczcj	401	36	potential	potential	JJ
cord-260476-whfyczcj	401	37	HIV	HIV	NNP
cord-260476-whfyczcj	401	38	restriction	restriction	NN
cord-260476-whfyczcj	401	39	factors	factor	NNS
cord-260476-whfyczcj	401	40	by	by	IN
cord-260476-whfyczcj	401	41	combining	combine	VBG
cord-260476-whfyczcj	401	42	evolutionary	evolutionary	JJ
cord-260476-whfyczcj	401	43	genomic	genomic	JJ
cord-260476-whfyczcj	401	44	signatures	signature	NNS
cord-260476-whfyczcj	401	45	with	with	IN
cord-260476-whfyczcj	401	46	functional	functional	JJ
cord-260476-whfyczcj	401	47	analyses	analysis	NNS
cord-260476-whfyczcj	401	48	Regulation	regulation	NN
cord-260476-whfyczcj	401	49	of	of	IN
cord-260476-whfyczcj	401	50	virus	virus	NN
cord-260476-whfyczcj	401	51	release	release	NN
cord-260476-whfyczcj	401	52	by	by	IN
cord-260476-whfyczcj	401	53	the	the	DT
cord-260476-whfyczcj	401	54	macrophage	macrophage	NN
cord-260476-whfyczcj	401	55	-	-	HYPH
cord-260476-whfyczcj	401	56	tropic	tropic	NN
cord-260476-whfyczcj	401	57	human	human	JJ
cord-260476-whfyczcj	401	58	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	401	59	virus	virus	NN
cord-260476-whfyczcj	401	60	type	type	NN
cord-260476-whfyczcj	401	61	1	1	CD
cord-260476-whfyczcj	401	62	AD8	AD8	NNP
cord-260476-whfyczcj	401	63	isolate	isolate	NN
cord-260476-whfyczcj	401	64	is	be	VBZ
cord-260476-whfyczcj	401	65	redundant	redundant	JJ
cord-260476-whfyczcj	401	66	and	and	CC
cord-260476-whfyczcj	401	67	can	can	MD
cord-260476-whfyczcj	401	68	be	be	VB
cord-260476-whfyczcj	401	69	controlled	control	VBN
cord-260476-whfyczcj	401	70	by	by	IN
cord-260476-whfyczcj	401	71	either	either	DT
cord-260476-whfyczcj	401	72	Vpu	Vpu	NNP
cord-260476-whfyczcj	401	73	or	or	CC
cord-260476-whfyczcj	401	74	Env	Env	NNP
cord-260476-whfyczcj	401	75	The	the	DT
cord-260476-whfyczcj	401	76	envelope	envelope	NN
cord-260476-whfyczcj	401	77	glycoprotein	glycoprotein	NN
cord-260476-whfyczcj	401	78	of	of	IN
cord-260476-whfyczcj	401	79	human	human	JJ
cord-260476-whfyczcj	401	80	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	401	81	virus	virus	NN
cord-260476-whfyczcj	401	82	type	type	NN
cord-260476-whfyczcj	401	83	2	2	CD
cord-260476-whfyczcj	401	84	enhances	enhance	VBZ
cord-260476-whfyczcj	401	85	viral	viral	JJ
cord-260476-whfyczcj	401	86	particle	particle	NN
cord-260476-whfyczcj	401	87	release	release	NN
cord-260476-whfyczcj	401	88	:	:	:
cord-260476-whfyczcj	401	89	A	a	DT
cord-260476-whfyczcj	401	90	Vpu	Vpu	NNP
cord-260476-whfyczcj	401	91	-	-	HYPH
cord-260476-whfyczcj	401	92	like	like	JJ
cord-260476-whfyczcj	401	93	factor	factor	NN
cord-260476-whfyczcj	401	94	?	?	.
cord-260476-whfyczcj	402	1	The	the	DT
cord-260476-whfyczcj	402	2	human	human	JJ
cord-260476-whfyczcj	402	3	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	402	4	virus	virus	NN
cord-260476-whfyczcj	402	5	(	(	-LRB-
cord-260476-whfyczcj	402	6	HIV	HIV	NNP
cord-260476-whfyczcj	402	7	)	)	-RRB-
cord-260476-whfyczcj	402	8	type	type	NN
cord-260476-whfyczcj	402	9	2	2	CD
cord-260476-whfyczcj	402	10	envelope	envelope	NN
cord-260476-whfyczcj	402	11	protein	protein	NN
cord-260476-whfyczcj	402	12	is	be	VBZ
cord-260476-whfyczcj	402	13	a	a	DT
cord-260476-whfyczcj	402	14	functional	functional	JJ
cord-260476-whfyczcj	402	15	complement	complement	NN
cord-260476-whfyczcj	402	16	to	to	IN
cord-260476-whfyczcj	402	17	HIV	HIV	NNP
cord-260476-whfyczcj	402	18	type	type	NN
cord-260476-whfyczcj	402	19	1	1	CD
cord-260476-whfyczcj	402	20	Vpu	Vpu	NNP
cord-260476-whfyczcj	402	21	that	that	WDT
cord-260476-whfyczcj	402	22	enhances	enhance	VBZ
cord-260476-whfyczcj	402	23	particle	particle	NN
cord-260476-whfyczcj	402	24	release	release	NN
cord-260476-whfyczcj	402	25	of	of	IN
cord-260476-whfyczcj	402	26	heterologous	heterologous	JJ
cord-260476-whfyczcj	402	27	retroviruses	retrovirus	NNS
cord-260476-whfyczcj	402	28	Nef	Nef	NNP
cord-260476-whfyczcj	402	29	proteins	protein	NNS
cord-260476-whfyczcj	402	30	from	from	IN
cord-260476-whfyczcj	402	31	simian	simian	JJ
cord-260476-whfyczcj	402	32	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	402	33	viruses	virus	NNS
cord-260476-whfyczcj	402	34	are	be	VBP
cord-260476-whfyczcj	402	35	tetherin	tetherin	VBN
cord-260476-whfyczcj	402	36	antagonists	antagonist	NNS
cord-260476-whfyczcj	402	37	Species	species	NN
cord-260476-whfyczcj	402	38	-	-	HYPH
cord-260476-whfyczcj	402	39	specific	specific	JJ
cord-260476-whfyczcj	402	40	activity	activity	NN
cord-260476-whfyczcj	402	41	of	of	IN
cord-260476-whfyczcj	402	42	SIV	SIV	NNP
cord-260476-whfyczcj	402	43	Nef	Nef	NNP
cord-260476-whfyczcj	402	44	and	and	CC
cord-260476-whfyczcj	402	45	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	402	46	Vpu	Vpu	NNP
cord-260476-whfyczcj	402	47	in	in	IN
cord-260476-whfyczcj	402	48	overcoming	overcome	VBG
cord-260476-whfyczcj	402	49	restriction	restriction	NN
cord-260476-whfyczcj	402	50	by	by	IN
cord-260476-whfyczcj	402	51	tetherin	tetherin	NNP
cord-260476-whfyczcj	402	52	/	/	SYM
cord-260476-whfyczcj	402	53	BST2	BST2	NNP
cord-260476-whfyczcj	403	1	The	the	DT
cord-260476-whfyczcj	403	2	evolution	evolution	NN
cord-260476-whfyczcj	403	3	of	of	IN
cord-260476-whfyczcj	403	4	pandemic	pandemic	NN
cord-260476-whfyczcj	403	5	and	and	CC
cord-260476-whfyczcj	403	6	non	non	JJ
cord-260476-whfyczcj	403	7	-	-	JJ
cord-260476-whfyczcj	403	8	pandemic	pandemic	JJ
cord-260476-whfyczcj	403	9	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	403	10	strains	strain	NNS
cord-260476-whfyczcj	403	11	has	have	VBZ
cord-260476-whfyczcj	403	12	been	be	VBN
cord-260476-whfyczcj	403	13	driven	drive	VBN
cord-260476-whfyczcj	403	14	by	by	IN
cord-260476-whfyczcj	403	15	Tetherin	Tetherin	NNP
cord-260476-whfyczcj	403	16	antagonism	antagonism	NN
cord-260476-whfyczcj	403	17	Human	human	JJ
cord-260476-whfyczcj	403	18	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	403	19	virus	virus	NN
cord-260476-whfyczcj	403	20	type	type	NN
cord-260476-whfyczcj	404	1	1	1	LS
cord-260476-whfyczcj	404	2	Vpu	Vpu	NNP
cord-260476-whfyczcj	404	3	protein	protein	NN
cord-260476-whfyczcj	404	4	induces	induce	VBZ
cord-260476-whfyczcj	404	5	rapid	rapid	JJ
cord-260476-whfyczcj	404	6	degradation	degradation	NN
cord-260476-whfyczcj	404	7	of	of	IN
cord-260476-whfyczcj	404	8	CD4	CD4	NNP
cord-260476-whfyczcj	404	9	CD4	CD4	NNP
cord-260476-whfyczcj	404	10	glycoprotein	glycoprotein	NN
cord-260476-whfyczcj	404	11	degradation	degradation	NN
cord-260476-whfyczcj	404	12	induced	induce	VBN
cord-260476-whfyczcj	404	13	by	by	IN
cord-260476-whfyczcj	404	14	human	human	JJ
cord-260476-whfyczcj	404	15	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	404	16	virus	virus	NN
cord-260476-whfyczcj	404	17	type	type	NN
cord-260476-whfyczcj	404	18	1	1	CD
cord-260476-whfyczcj	404	19	Vpu	Vpu	NNP
cord-260476-whfyczcj	404	20	protein	protein	NN
cord-260476-whfyczcj	404	21	requires	require	VBZ
cord-260476-whfyczcj	404	22	the	the	DT
cord-260476-whfyczcj	404	23	function	function	NN
cord-260476-whfyczcj	404	24	of	of	IN
cord-260476-whfyczcj	404	25	proteasomes	proteasomes	NNP
cord-260476-whfyczcj	404	26	and	and	CC
cord-260476-whfyczcj	404	27	the	the	DT
cord-260476-whfyczcj	404	28	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	404	29	-	-	HYPH
cord-260476-whfyczcj	404	30	conjugating	conjugate	VBG
cord-260476-whfyczcj	404	31	pathway	pathway	NN
cord-260476-whfyczcj	404	32	Requirements	requirement	NNS
cord-260476-whfyczcj	404	33	for	for	IN
cord-260476-whfyczcj	404	34	the	the	DT
cord-260476-whfyczcj	404	35	selective	selective	JJ
cord-260476-whfyczcj	404	36	degradation	degradation	NN
cord-260476-whfyczcj	404	37	of	of	IN
cord-260476-whfyczcj	404	38	CD4	CD4	NNP
cord-260476-whfyczcj	404	39	receptor	receptor	NN
cord-260476-whfyczcj	404	40	molecules	molecule	NNS
cord-260476-whfyczcj	404	41	by	by	IN
cord-260476-whfyczcj	404	42	the	the	DT
cord-260476-whfyczcj	404	43	human	human	JJ
cord-260476-whfyczcj	404	44	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	404	45	virus	virus	NN
cord-260476-whfyczcj	404	46	type	type	NN
cord-260476-whfyczcj	404	47	1	1	CD
cord-260476-whfyczcj	404	48	Vpu	Vpu	NNP
cord-260476-whfyczcj	404	49	protein	protein	NN
cord-260476-whfyczcj	404	50	in	in	IN
cord-260476-whfyczcj	404	51	the	the	DT
cord-260476-whfyczcj	404	52	endoplasmic	endoplasmic	NN
cord-260476-whfyczcj	404	53	reticulum	reticulum	NN
cord-260476-whfyczcj	404	54	Multilayered	multilayered	JJ
cord-260476-whfyczcj	404	55	mechanism	mechanism	NN
cord-260476-whfyczcj	404	56	of	of	IN
cord-260476-whfyczcj	404	57	CD4	CD4	NNP
cord-260476-whfyczcj	404	58	downregulation	downregulation	NN
cord-260476-whfyczcj	404	59	by	by	IN
cord-260476-whfyczcj	404	60	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	404	61	Vpu	Vpu	NNP
cord-260476-whfyczcj	404	62	involving	involve	VBG
cord-260476-whfyczcj	404	63	distinct	distinct	JJ
cord-260476-whfyczcj	404	64	ER	ER	NNP
cord-260476-whfyczcj	404	65	retention	retention	NN
cord-260476-whfyczcj	404	66	and	and	CC
cord-260476-whfyczcj	404	67	ERAD	ERAD	NNP
cord-260476-whfyczcj	404	68	targeting	target	VBG
cord-260476-whfyczcj	404	69	steps	step	NNS
cord-260476-whfyczcj	404	70	Transmembrane	Transmembrane	NNP
cord-260476-whfyczcj	404	71	domain	domain	NN
cord-260476-whfyczcj	404	72	determinants	determinant	NNS
cord-260476-whfyczcj	404	73	of	of	IN
cord-260476-whfyczcj	404	74	CD4	CD4	NNP
cord-260476-whfyczcj	404	75	downregulation	downregulation	NN
cord-260476-whfyczcj	404	76	by	by	IN
cord-260476-whfyczcj	404	77	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	404	78	Vpu	Vpu	NNP
cord-260476-whfyczcj	404	79	CD4	CD4	NNP
cord-260476-whfyczcj	404	80	and	and	CC
cord-260476-whfyczcj	404	81	BST-2	BST-2	NNP
cord-260476-whfyczcj	404	82	/	/	SYM
cord-260476-whfyczcj	404	83	tetherin	tetherin	NN
cord-260476-whfyczcj	404	84	proteins	protein	NNS
cord-260476-whfyczcj	404	85	retro	retro	JJ
cord-260476-whfyczcj	404	86	-	-	:
cord-260476-whfyczcj	404	87	translocate	translocate	VBP
cord-260476-whfyczcj	404	88	from	from	IN
cord-260476-whfyczcj	404	89	endoplasmic	endoplasmic	NN
cord-260476-whfyczcj	404	90	reticulum	reticulum	NN
cord-260476-whfyczcj	404	91	to	to	IN
cord-260476-whfyczcj	404	92	cytosol	cytosol	NN
cord-260476-whfyczcj	404	93	as	as	IN
cord-260476-whfyczcj	404	94	partially	partially	RB
cord-260476-whfyczcj	404	95	folded	fold	VBN
cord-260476-whfyczcj	404	96	and	and	CC
cord-260476-whfyczcj	404	97	multimeric	multimeric	JJ
cord-260476-whfyczcj	404	98	molecules	molecule	NNS
cord-260476-whfyczcj	404	99	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	404	100	Vpu	Vpu	NNP
cord-260476-whfyczcj	404	101	downmodulates	downmodulate	VBZ
cord-260476-whfyczcj	404	102	ICAM-1	icam-1	NN
cord-260476-whfyczcj	404	103	expression	expression	NN
cord-260476-whfyczcj	404	104	,	,	,
cord-260476-whfyczcj	404	105	resulting	result	VBG
cord-260476-whfyczcj	404	106	in	in	IN
cord-260476-whfyczcj	404	107	decreased	decrease	VBN
cord-260476-whfyczcj	404	108	killing	killing	NN
cord-260476-whfyczcj	404	109	of	of	IN
cord-260476-whfyczcj	404	110	infected	infected	JJ
cord-260476-whfyczcj	404	111	CD4(+	cd4(+	CD
cord-260476-whfyczcj	404	112	)	)	-RRB-
cord-260476-whfyczcj	405	1	T	t	NN
cord-260476-whfyczcj	405	2	cells	cell	NNS
cord-260476-whfyczcj	405	3	by	by	IN
cord-260476-whfyczcj	405	4	NK	NK	NNP
cord-260476-whfyczcj	405	5	cells	cell	NNS
cord-260476-whfyczcj	405	6	Cell	cell	NN
cord-260476-whfyczcj	405	7	surface	surface	NN
cord-260476-whfyczcj	405	8	proteomic	proteomic	JJ
cord-260476-whfyczcj	405	9	map	map	NN
cord-260476-whfyczcj	405	10	of	of	IN
cord-260476-whfyczcj	405	11	HIV	HIV	NNP
cord-260476-whfyczcj	405	12	infection	infection	NN
cord-260476-whfyczcj	405	13	reveals	reveal	VBZ
cord-260476-whfyczcj	405	14	antagonism	antagonism	NN
cord-260476-whfyczcj	405	15	of	of	IN
cord-260476-whfyczcj	405	16	amino	amino	NN
cord-260476-whfyczcj	405	17	acid	acid	NN
cord-260476-whfyczcj	405	18	metabolism	metabolism	NN
cord-260476-whfyczcj	405	19	by	by	IN
cord-260476-whfyczcj	405	20	Vpu	Vpu	NNP
cord-260476-whfyczcj	405	21	and	and	CC
cord-260476-whfyczcj	405	22	Nef	Nef	NNP
cord-260476-whfyczcj	405	23	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	405	24	Vpr	Vpr	NNP
cord-260476-whfyczcj	405	25	loads	load	VBZ
cord-260476-whfyczcj	405	26	uracil	uracil	NN
cord-260476-whfyczcj	405	27	DNA	DNA	NNP
cord-260476-whfyczcj	405	28	glycosylase-2	glycosylase-2	NNP
cord-260476-whfyczcj	405	29	onto	onto	IN
cord-260476-whfyczcj	405	30	DCAF1	dcaf1	NN
cord-260476-whfyczcj	405	31	,	,	,
cord-260476-whfyczcj	405	32	a	a	DT
cord-260476-whfyczcj	405	33	substrate	substrate	NN
cord-260476-whfyczcj	405	34	recognition	recognition	NN
cord-260476-whfyczcj	405	35	subunit	subunit	NN
cord-260476-whfyczcj	405	36	of	of	IN
cord-260476-whfyczcj	405	37	a	a	DT
cord-260476-whfyczcj	405	38	cullin	cullin	NNP
cord-260476-whfyczcj	405	39	4A	4a	NN
cord-260476-whfyczcj	405	40	-	-	HYPH
cord-260476-whfyczcj	405	41	ring	ring	NN
cord-260476-whfyczcj	405	42	E3	e3	NN
cord-260476-whfyczcj	405	43	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	405	44	ligase	ligase	NN
cord-260476-whfyczcj	405	45	for	for	IN
cord-260476-whfyczcj	405	46	proteasome	proteasome	NN
cord-260476-whfyczcj	405	47	-	-	HYPH
cord-260476-whfyczcj	405	48	dependent	dependent	JJ
cord-260476-whfyczcj	405	49	degradation	degradation	NN
cord-260476-whfyczcj	406	1	The	the	DT
cord-260476-whfyczcj	406	2	DDB1-DCAF1-Vpr	DDB1-DCAF1-Vpr	NNP
cord-260476-whfyczcj	406	3	-	-	HYPH
cord-260476-whfyczcj	406	4	UNG2	ung2	JJ
cord-260476-whfyczcj	406	5	crystal	crystal	NN
cord-260476-whfyczcj	406	6	structure	structure	NN
cord-260476-whfyczcj	406	7	reveals	reveal	VBZ
cord-260476-whfyczcj	406	8	how	how	WRB
cord-260476-whfyczcj	406	9	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	406	10	Vpr	Vpr	NNP
cord-260476-whfyczcj	406	11	steers	steer	VBZ
cord-260476-whfyczcj	406	12	human	human	JJ
cord-260476-whfyczcj	406	13	UNG2	UNG2	NNP
cord-260476-whfyczcj	406	14	toward	toward	IN
cord-260476-whfyczcj	406	15	destruction	destruction	NN
cord-260476-whfyczcj	406	16	Human	human	JJ
cord-260476-whfyczcj	406	17	immunodeficiency	immunodeficiency	NN
cord-260476-whfyczcj	406	18	virus	virus	NN
cord-260476-whfyczcj	406	19	type	type	NN
cord-260476-whfyczcj	406	20	1	1	CD
cord-260476-whfyczcj	406	21	Vpr	Vpr	NNP
cord-260476-whfyczcj	406	22	induces	induce	VBZ
cord-260476-whfyczcj	406	23	the	the	DT
cord-260476-whfyczcj	406	24	degradation	degradation	NN
cord-260476-whfyczcj	406	25	of	of	IN
cord-260476-whfyczcj	406	26	the	the	DT
cord-260476-whfyczcj	406	27	UNG	ung	NN
cord-260476-whfyczcj	406	28	and	and	CC
cord-260476-whfyczcj	407	1	SMUG	smug	JJ
cord-260476-whfyczcj	407	2	uracil	uracil	NN
cord-260476-whfyczcj	407	3	-	-	HYPH
cord-260476-whfyczcj	407	4	DNA	dna	NN
cord-260476-whfyczcj	407	5	glycosylases	glycosylase	NNS
cord-260476-whfyczcj	408	1	The	the	DT
cord-260476-whfyczcj	408	2	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	408	3	accessory	accessory	NN
cord-260476-whfyczcj	408	4	protein	protein	NN
cord-260476-whfyczcj	408	5	Vpr	Vpr	NNP
cord-260476-whfyczcj	408	6	induces	induce	VBZ
cord-260476-whfyczcj	408	7	the	the	DT
cord-260476-whfyczcj	408	8	degradation	degradation	NN
cord-260476-whfyczcj	408	9	of	of	IN
cord-260476-whfyczcj	408	10	the	the	DT
cord-260476-whfyczcj	408	11	anti	anti	JJ
cord-260476-whfyczcj	408	12	-	-	NNP
cord-260476-whfyczcj	408	13	HIV-1	hiv-1	JJ
cord-260476-whfyczcj	408	14	agent	agent	NN
cord-260476-whfyczcj	408	15	APOBEC3	apobec3	DT
cord-260476-whfyczcj	408	16	G	g	NN
cord-260476-whfyczcj	408	17	through	through	IN
cord-260476-whfyczcj	408	18	a	a	DT
cord-260476-whfyczcj	408	19	VprBP	vprbp	NN
cord-260476-whfyczcj	408	20	-	-	HYPH
cord-260476-whfyczcj	408	21	mediated	mediate	VBN
cord-260476-whfyczcj	408	22	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	408	23	pathway	pathway	NN
cord-260476-whfyczcj	409	1	The	the	DT
cord-260476-whfyczcj	409	2	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	409	3	protein	protein	NN
cord-260476-whfyczcj	409	4	Vpr	Vpr	NNP
cord-260476-whfyczcj	409	5	targets	target	VBZ
cord-260476-whfyczcj	409	6	the	the	DT
cord-260476-whfyczcj	409	7	endoribonuclease	endoribonuclease	NN
cord-260476-whfyczcj	409	8	Dicer	Dicer	NNP
cord-260476-whfyczcj	409	9	for	for	IN
cord-260476-whfyczcj	409	10	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	409	11	degradation	degradation	NN
cord-260476-whfyczcj	409	12	to	to	TO
cord-260476-whfyczcj	409	13	boost	boost	VB
cord-260476-whfyczcj	409	14	macrophage	macrophage	NN
cord-260476-whfyczcj	409	15	infection	infection	NN
cord-260476-whfyczcj	410	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	410	2	Vpr	Vpr	NNP
cord-260476-whfyczcj	410	3	degrades	degrade	VBZ
cord-260476-whfyczcj	410	4	the	the	DT
cord-260476-whfyczcj	410	5	HLTF	hltf	NN
cord-260476-whfyczcj	410	6	DNA	dna	NN
cord-260476-whfyczcj	410	7	translocase	translocase	NN
cord-260476-whfyczcj	410	8	in	in	IN
cord-260476-whfyczcj	410	9	T	t	NN
cord-260476-whfyczcj	410	10	cells	cell	NNS
cord-260476-whfyczcj	410	11	and	and	CC
cord-260476-whfyczcj	410	12	macrophages	macrophage	NNS
cord-260476-whfyczcj	410	13	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	410	14	Vpr	Vpr	NNP
cord-260476-whfyczcj	410	15	protein	protein	NN
cord-260476-whfyczcj	410	16	Enhances	enhance	VBZ
cord-260476-whfyczcj	410	17	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	410	18	degradation	degradation	NN
cord-260476-whfyczcj	410	19	of	of	IN
cord-260476-whfyczcj	410	20	MCM10	MCM10	NNP
cord-260476-whfyczcj	410	21	DNA	dna	NN
cord-260476-whfyczcj	410	22	replication	replication	NN
cord-260476-whfyczcj	410	23	factor	factor	NN
cord-260476-whfyczcj	410	24	through	through	IN
cord-260476-whfyczcj	410	25	the	the	DT
cord-260476-whfyczcj	410	26	Cul4-DDB1[VprBP	cul4-ddb1[vprbp	CD
cord-260476-whfyczcj	410	27	]	]	-RRB-
cord-260476-whfyczcj	410	28	E3	e3	NN
cord-260476-whfyczcj	410	29	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	410	30	ligase	ligase	NN
cord-260476-whfyczcj	410	31	to	to	TO
cord-260476-whfyczcj	410	32	induce	induce	VB
cord-260476-whfyczcj	410	33	G2	G2	NNP
cord-260476-whfyczcj	410	34	/	/	SYM
cord-260476-whfyczcj	410	35	M	M	NNP
cord-260476-whfyczcj	410	36	cell	cell	NN
cord-260476-whfyczcj	410	37	cycle	cycle	NN
cord-260476-whfyczcj	410	38	arrest	arrest	NN
cord-260476-whfyczcj	411	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	411	2	Vpr	Vpr	NNP
cord-260476-whfyczcj	411	3	induces	induce	VBZ
cord-260476-whfyczcj	411	4	the	the	DT
cord-260476-whfyczcj	411	5	degradation	degradation	NN
cord-260476-whfyczcj	411	6	of	of	IN
cord-260476-whfyczcj	411	7	ZIP	zip	NN
cord-260476-whfyczcj	411	8	and	and	CC
cord-260476-whfyczcj	411	9	sZIP	szip	NN
cord-260476-whfyczcj	411	10	,	,	,
cord-260476-whfyczcj	411	11	adaptors	adaptor	NNS
cord-260476-whfyczcj	411	12	of	of	IN
cord-260476-whfyczcj	411	13	the	the	DT
cord-260476-whfyczcj	411	14	NuRD	NuRD	NNP
cord-260476-whfyczcj	411	15	chromatin	chromatin	NN
cord-260476-whfyczcj	411	16	remodeling	remodeling	NN
cord-260476-whfyczcj	411	17	complex	complex	NN
cord-260476-whfyczcj	411	18	,	,	,
cord-260476-whfyczcj	411	19	by	by	IN
cord-260476-whfyczcj	411	20	hijacking	hijack	VBG
cord-260476-whfyczcj	411	21	DCAF1/	DCAF1/	NNS
cord-260476-whfyczcj	412	1	VprBP	VprBP	NNP
cord-260476-whfyczcj	413	1	HIV-1	HIV-1	NNP
cord-260476-whfyczcj	413	2	Vpr	Vpr	NNP
cord-260476-whfyczcj	413	3	protein	protein	NN
cord-260476-whfyczcj	413	4	induces	induce	VBZ
cord-260476-whfyczcj	413	5	proteasomal	proteasomal	JJ
cord-260476-whfyczcj	413	6	degradation	degradation	NN
cord-260476-whfyczcj	413	7	of	of	IN
cord-260476-whfyczcj	413	8	chromatin	chromatin	NN
cord-260476-whfyczcj	413	9	-	-	HYPH
cord-260476-whfyczcj	413	10	associated	associate	VBN
cord-260476-whfyczcj	413	11	class	class	NN
cord-260476-whfyczcj	413	12	I	-PRON-	PRP
cord-260476-whfyczcj	413	13	HDACs	hdac	VBZ
cord-260476-whfyczcj	413	14	to	to	TO
cord-260476-whfyczcj	413	15	overcome	overcome	VB
cord-260476-whfyczcj	413	16	latent	latent	JJ
cord-260476-whfyczcj	413	17	infection	infection	NN
cord-260476-whfyczcj	413	18	of	of	IN
cord-260476-whfyczcj	413	19	macrophages	macrophage	NNS
cord-260476-whfyczcj	413	20	The	the	DT
cord-260476-whfyczcj	413	21	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	413	22	-	-	HYPH
cord-260476-whfyczcj	413	23	proteasome	proteasome	VBN
cord-260476-whfyczcj	413	24	system	system	NN
cord-260476-whfyczcj	413	25	in	in	IN
cord-260476-whfyczcj	413	26	HIV	HIV	NNP
cord-260476-whfyczcj	413	27	replication	replication	NN
cord-260476-whfyczcj	413	28	:	:	:
cord-260476-whfyczcj	413	29	Potential	potential	JJ
cord-260476-whfyczcj	413	30	targets	target	NNS
cord-260476-whfyczcj	413	31	for	for	IN
cord-260476-whfyczcj	413	32	antiretroviral	antiretroviral	JJ
cord-260476-whfyczcj	413	33	therapy	therapy	NN
cord-260476-whfyczcj	413	34	Inhibition	Inhibition	NNP
cord-260476-whfyczcj	413	35	of	of	IN
cord-260476-whfyczcj	413	36	Vpx	Vpx	NNP
cord-260476-whfyczcj	413	37	-	-	HYPH
cord-260476-whfyczcj	413	38	mediated	mediate	VBN
cord-260476-whfyczcj	413	39	SAMHD1	SAMHD1	NNS
cord-260476-whfyczcj	413	40	and	and	CC
cord-260476-whfyczcj	413	41	Vpr	Vpr	NNP
cord-260476-whfyczcj	413	42	-	-	HYPH
cord-260476-whfyczcj	413	43	mediated	mediate	VBN
cord-260476-whfyczcj	413	44	host	host	NN
cord-260476-whfyczcj	413	45	helicase	helicase	NN
cord-260476-whfyczcj	413	46	transcription	transcription	NN
cord-260476-whfyczcj	413	47	factor	factor	NN
cord-260476-whfyczcj	413	48	degradation	degradation	NN
cord-260476-whfyczcj	413	49	by	by	IN
cord-260476-whfyczcj	413	50	selective	selective	JJ
cord-260476-whfyczcj	413	51	disruption	disruption	NN
cord-260476-whfyczcj	413	52	of	of	IN
cord-260476-whfyczcj	413	53	viral	viral	JJ
cord-260476-whfyczcj	413	54	CRL4	CRL4	NNP
cord-260476-whfyczcj	413	55	(	(	-LRB-
cord-260476-whfyczcj	413	56	DCAF1	DCAF1	NNP
cord-260476-whfyczcj	413	57	)	)	-RRB-
cord-260476-whfyczcj	413	58	E3	e3	NN
cord-260476-whfyczcj	413	59	ubiquitin	ubiquitin	NN
cord-260476-whfyczcj	413	60	ligase	ligase	NN
cord-260476-whfyczcj	413	61	assembly	assembly	NN