id	sid	tid	token	lemma	pos
cord-259237-aty0vrat	1	1	key	key	JJ
cord-259237-aty0vrat	2	1	:	:	:
cord-259237-aty0vrat	2	2	cord-259237-aty0vrat	cord-259237-aty0vrat	NNP
cord-259237-aty0vrat	2	3	authors	author	NNS
cord-259237-aty0vrat	2	4	:	:	:
cord-259237-aty0vrat	2	5	Frabutt	Frabutt	NNP
cord-259237-aty0vrat	2	6	,	,	,
cord-259237-aty0vrat	2	7	Dylan	Dylan	NNP
cord-259237-aty0vrat	2	8	A.	a.	NN
cord-259237-aty0vrat	2	9	;	;	:
cord-259237-aty0vrat	2	10	Zheng	Zheng	NNP
cord-259237-aty0vrat	2	11	,	,	,
cord-259237-aty0vrat	2	12	Yong	Yong	NNP
cord-259237-aty0vrat	2	13	-	-	HYPH
cord-259237-aty0vrat	2	14	Hui	Hui	NNP
cord-259237-aty0vrat	3	1	title	title	NN
cord-259237-aty0vrat	3	2	:	:	:
cord-259237-aty0vrat	3	3	Arms	arm	NNS
cord-259237-aty0vrat	3	4	Race	race	NN
cord-259237-aty0vrat	3	5	between	between	IN
cord-259237-aty0vrat	3	6	Enveloped	Enveloped	NNP
cord-259237-aty0vrat	3	7	Viruses	Viruses	NNPS
cord-259237-aty0vrat	3	8	and	and	CC
cord-259237-aty0vrat	3	9	the	the	DT
cord-259237-aty0vrat	3	10	Host	Host	NNP
cord-259237-aty0vrat	3	11	ERAD	ERAD	NNP
cord-259237-aty0vrat	3	12	Machinery	Machinery	NNP
cord-259237-aty0vrat	3	13	date	date	NN
cord-259237-aty0vrat	3	14	:	:	:
cord-259237-aty0vrat	3	15	2016	2016	CD
cord-259237-aty0vrat	3	16	-	-	HYPH
cord-259237-aty0vrat	3	17	09	09	CD
cord-259237-aty0vrat	3	18	-	-	SYM
cord-259237-aty0vrat	3	19	19	19	CD
cord-259237-aty0vrat	3	20	journal	journal	NN
cord-259237-aty0vrat	3	21	:	:	:
cord-259237-aty0vrat	4	1	Viruses	virus	NNS
cord-259237-aty0vrat	4	2	DOI	DOI	NNP
cord-259237-aty0vrat	4	3	:	:	:
cord-259237-aty0vrat	5	1	10.3390	10.3390	CD
cord-259237-aty0vrat	5	2	/	/	SYM
cord-259237-aty0vrat	5	3	v8090255	v8090255	NN
cord-259237-aty0vrat	5	4	sha	sha	NN
cord-259237-aty0vrat	5	5	:	:	:
cord-259237-aty0vrat	5	6	8befe1b5905e502b127ae478f3b9de1d6e25e317	8befe1b5905e502b127ae478f3b9de1d6e25e317	CD
cord-259237-aty0vrat	5	7	doc_id	doc_id	CD
cord-259237-aty0vrat	5	8	:	:	:
cord-259237-aty0vrat	5	9	259237	259237	CD
cord-259237-aty0vrat	5	10	cord_uid	cord_uid	NNS
cord-259237-aty0vrat	5	11	:	:	:
cord-259237-aty0vrat	6	1	aty0vrat	aty0vrat	NNP
cord-259237-aty0vrat	6	2	Enveloped	envelop	VBN
cord-259237-aty0vrat	6	3	viruses	virus	NNS
cord-259237-aty0vrat	6	4	represent	represent	VBP
cord-259237-aty0vrat	6	5	a	a	DT
cord-259237-aty0vrat	6	6	significant	significant	JJ
cord-259237-aty0vrat	6	7	category	category	NN
cord-259237-aty0vrat	6	8	of	of	IN
cord-259237-aty0vrat	6	9	pathogens	pathogen	NNS
cord-259237-aty0vrat	6	10	that	that	WDT
cord-259237-aty0vrat	6	11	cause	cause	VBP
cord-259237-aty0vrat	6	12	serious	serious	JJ
cord-259237-aty0vrat	6	13	diseases	disease	NNS
cord-259237-aty0vrat	6	14	in	in	IN
cord-259237-aty0vrat	6	15	animals	animal	NNS
cord-259237-aty0vrat	6	16	.	.	.
cord-259237-aty0vrat	7	1	These	these	DT
cord-259237-aty0vrat	7	2	viruses	virus	NNS
cord-259237-aty0vrat	7	3	express	express	VBP
cord-259237-aty0vrat	7	4	envelope	envelope	NN
cord-259237-aty0vrat	7	5	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	7	6	that	that	WDT
cord-259237-aty0vrat	7	7	are	be	VBP
cord-259237-aty0vrat	7	8	singularly	singularly	RB
cord-259237-aty0vrat	7	9	important	important	JJ
cord-259237-aty0vrat	7	10	during	during	IN
cord-259237-aty0vrat	7	11	the	the	DT
cord-259237-aty0vrat	7	12	infection	infection	NN
cord-259237-aty0vrat	7	13	of	of	IN
cord-259237-aty0vrat	7	14	host	host	NN
cord-259237-aty0vrat	7	15	cells	cell	NNS
cord-259237-aty0vrat	7	16	by	by	IN
cord-259237-aty0vrat	7	17	mediating	mediate	VBG
cord-259237-aty0vrat	7	18	fusion	fusion	NN
cord-259237-aty0vrat	7	19	between	between	IN
cord-259237-aty0vrat	7	20	the	the	DT
cord-259237-aty0vrat	7	21	viral	viral	JJ
cord-259237-aty0vrat	7	22	envelope	envelope	NN
cord-259237-aty0vrat	7	23	and	and	CC
cord-259237-aty0vrat	7	24	host	host	NN
cord-259237-aty0vrat	7	25	cell	cell	NN
cord-259237-aty0vrat	7	26	membranes	membrane	NNS
cord-259237-aty0vrat	7	27	.	.	.
cord-259237-aty0vrat	8	1	Despite	despite	IN
cord-259237-aty0vrat	8	2	low	low	JJ
cord-259237-aty0vrat	8	3	homology	homology	NN
cord-259237-aty0vrat	8	4	at	at	IN
cord-259237-aty0vrat	8	5	protein	protein	NN
cord-259237-aty0vrat	8	6	levels	level	NNS
cord-259237-aty0vrat	8	7	,	,	,
cord-259237-aty0vrat	8	8	three	three	CD
cord-259237-aty0vrat	8	9	classes	class	NNS
cord-259237-aty0vrat	8	10	of	of	IN
cord-259237-aty0vrat	8	11	viral	viral	JJ
cord-259237-aty0vrat	8	12	fusion	fusion	NN
cord-259237-aty0vrat	8	13	proteins	protein	NNS
cord-259237-aty0vrat	8	14	have	have	VBP
cord-259237-aty0vrat	8	15	,	,	,
cord-259237-aty0vrat	8	16	as	as	IN
cord-259237-aty0vrat	8	17	of	of	IN
cord-259237-aty0vrat	8	18	yet	yet	RB
cord-259237-aty0vrat	8	19	,	,	,
cord-259237-aty0vrat	8	20	been	be	VBN
cord-259237-aty0vrat	8	21	identified	identify	VBN
cord-259237-aty0vrat	8	22	based	base	VBN
cord-259237-aty0vrat	8	23	on	on	IN
cord-259237-aty0vrat	8	24	structural	structural	JJ
cord-259237-aty0vrat	8	25	similarities	similarity	NNS
cord-259237-aty0vrat	8	26	.	.	.
cord-259237-aty0vrat	9	1	Their	-PRON-	PRP$
cord-259237-aty0vrat	9	2	incorporation	incorporation	NN
cord-259237-aty0vrat	9	3	into	into	IN
cord-259237-aty0vrat	9	4	viral	viral	JJ
cord-259237-aty0vrat	9	5	particles	particle	NNS
cord-259237-aty0vrat	9	6	is	be	VBZ
cord-259237-aty0vrat	9	7	dependent	dependent	JJ
cord-259237-aty0vrat	9	8	upon	upon	IN
cord-259237-aty0vrat	9	9	their	-PRON-	PRP$
cord-259237-aty0vrat	9	10	proper	proper	JJ
cord-259237-aty0vrat	9	11	sub	sub	JJ
cord-259237-aty0vrat	9	12	-	-	JJ
cord-259237-aty0vrat	9	13	cellular	cellular	JJ
cord-259237-aty0vrat	9	14	localization	localization	NN
cord-259237-aty0vrat	9	15	after	after	IN
cord-259237-aty0vrat	9	16	being	be	VBG
cord-259237-aty0vrat	9	17	expressed	express	VBN
cord-259237-aty0vrat	9	18	and	and	CC
cord-259237-aty0vrat	9	19	folded	fold	VBN
cord-259237-aty0vrat	9	20	properly	properly	RB
cord-259237-aty0vrat	9	21	in	in	IN
cord-259237-aty0vrat	9	22	the	the	DT
cord-259237-aty0vrat	9	23	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	9	24	reticulum	reticulum	NN
cord-259237-aty0vrat	9	25	(	(	-LRB-
cord-259237-aty0vrat	9	26	ER	ER	NNP
cord-259237-aty0vrat	9	27	)	)	-RRB-
cord-259237-aty0vrat	9	28	.	.	.
cord-259237-aty0vrat	10	1	However	however	RB
cord-259237-aty0vrat	10	2	,	,	,
cord-259237-aty0vrat	10	3	viral	viral	JJ
cord-259237-aty0vrat	10	4	protein	protein	NN
cord-259237-aty0vrat	10	5	expression	expression	NN
cord-259237-aty0vrat	10	6	can	can	MD
cord-259237-aty0vrat	10	7	cause	cause	VB
cord-259237-aty0vrat	10	8	stress	stress	NN
cord-259237-aty0vrat	10	9	in	in	IN
cord-259237-aty0vrat	10	10	the	the	DT
cord-259237-aty0vrat	10	11	ER	ER	NNP
cord-259237-aty0vrat	10	12	,	,	,
cord-259237-aty0vrat	10	13	and	and	CC
cord-259237-aty0vrat	10	14	host	host	NN
cord-259237-aty0vrat	10	15	cells	cell	NNS
cord-259237-aty0vrat	10	16	respond	respond	VBP
cord-259237-aty0vrat	10	17	to	to	TO
cord-259237-aty0vrat	10	18	alleviate	alleviate	VB
cord-259237-aty0vrat	10	19	the	the	DT
cord-259237-aty0vrat	10	20	ER	ER	NNP
cord-259237-aty0vrat	10	21	stress	stress	NN
cord-259237-aty0vrat	10	22	in	in	IN
cord-259237-aty0vrat	10	23	the	the	DT
cord-259237-aty0vrat	10	24	form	form	NN
cord-259237-aty0vrat	10	25	of	of	IN
cord-259237-aty0vrat	10	26	the	the	DT
cord-259237-aty0vrat	10	27	unfolded	unfolded	JJ
cord-259237-aty0vrat	10	28	protein	protein	NN
cord-259237-aty0vrat	10	29	response	response	NN
cord-259237-aty0vrat	10	30	(	(	-LRB-
cord-259237-aty0vrat	10	31	UPR	UPR	NNP
cord-259237-aty0vrat	10	32	)	)	-RRB-
cord-259237-aty0vrat	10	33	;	;	:
cord-259237-aty0vrat	10	34	the	the	DT
cord-259237-aty0vrat	10	35	effects	effect	NNS
cord-259237-aty0vrat	10	36	of	of	IN
cord-259237-aty0vrat	10	37	which	which	WDT
cord-259237-aty0vrat	10	38	have	have	VBP
cord-259237-aty0vrat	10	39	been	be	VBN
cord-259237-aty0vrat	10	40	observed	observe	VBN
cord-259237-aty0vrat	10	41	to	to	TO
cord-259237-aty0vrat	10	42	potentiate	potentiate	VB
cord-259237-aty0vrat	10	43	or	or	CC
cord-259237-aty0vrat	10	44	inhibit	inhibit	VB
cord-259237-aty0vrat	10	45	viral	viral	JJ
cord-259237-aty0vrat	10	46	infection	infection	NN
cord-259237-aty0vrat	10	47	.	.	.
cord-259237-aty0vrat	11	1	One	one	CD
cord-259237-aty0vrat	11	2	important	important	JJ
cord-259237-aty0vrat	11	3	arm	arm	NN
cord-259237-aty0vrat	11	4	of	of	IN
cord-259237-aty0vrat	11	5	UPR	UPR	NNP
cord-259237-aty0vrat	11	6	is	be	VBZ
cord-259237-aty0vrat	11	7	to	to	TO
cord-259237-aty0vrat	11	8	elevate	elevate	VB
cord-259237-aty0vrat	11	9	the	the	DT
cord-259237-aty0vrat	11	10	capacity	capacity	NN
cord-259237-aty0vrat	11	11	of	of	IN
cord-259237-aty0vrat	11	12	the	the	DT
cord-259237-aty0vrat	11	13	ER	ER	NNP
cord-259237-aty0vrat	11	14	-	-	HYPH
cord-259237-aty0vrat	11	15	associated	associate	VBN
cord-259237-aty0vrat	11	16	protein	protein	NN
cord-259237-aty0vrat	11	17	degradation	degradation	NN
cord-259237-aty0vrat	11	18	(	(	-LRB-
cord-259237-aty0vrat	11	19	ERAD	ERAD	NNP
cord-259237-aty0vrat	11	20	)	)	-RRB-
cord-259237-aty0vrat	11	21	pathway	pathway	NN
cord-259237-aty0vrat	11	22	,	,	,
cord-259237-aty0vrat	11	23	which	which	WDT
cord-259237-aty0vrat	11	24	is	be	VBZ
cord-259237-aty0vrat	11	25	comprised	comprise	VBN
cord-259237-aty0vrat	11	26	of	of	IN
cord-259237-aty0vrat	11	27	host	host	NN
cord-259237-aty0vrat	11	28	quality	quality	NN
cord-259237-aty0vrat	11	29	control	control	NN
cord-259237-aty0vrat	11	30	machinery	machinery	NN
cord-259237-aty0vrat	11	31	that	that	WDT
cord-259237-aty0vrat	11	32	ensures	ensure	VBZ
cord-259237-aty0vrat	11	33	proper	proper	JJ
cord-259237-aty0vrat	11	34	protein	protein	NN
cord-259237-aty0vrat	11	35	folding	folding	NN
cord-259237-aty0vrat	11	36	.	.	.
cord-259237-aty0vrat	12	1	In	in	IN
cord-259237-aty0vrat	12	2	this	this	DT
cord-259237-aty0vrat	12	3	review	review	NN
cord-259237-aty0vrat	12	4	,	,	,
cord-259237-aty0vrat	12	5	we	-PRON-	PRP
cord-259237-aty0vrat	12	6	provide	provide	VBP
cord-259237-aty0vrat	12	7	relevant	relevant	JJ
cord-259237-aty0vrat	12	8	details	detail	NNS
cord-259237-aty0vrat	12	9	regarding	regard	VBG
cord-259237-aty0vrat	12	10	viral	viral	JJ
cord-259237-aty0vrat	12	11	envelope	envelope	NN
cord-259237-aty0vrat	12	12	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	12	13	,	,	,
cord-259237-aty0vrat	12	14	UPR	UPR	NNP
cord-259237-aty0vrat	12	15	,	,	,
cord-259237-aty0vrat	12	16	ERAD	ERAD	NNP
cord-259237-aty0vrat	12	17	,	,	,
cord-259237-aty0vrat	12	18	and	and	CC
cord-259237-aty0vrat	12	19	their	-PRON-	PRP$
cord-259237-aty0vrat	12	20	interactions	interaction	NNS
cord-259237-aty0vrat	12	21	in	in	IN
cord-259237-aty0vrat	12	22	host	host	NN
cord-259237-aty0vrat	12	23	cells	cell	NNS
cord-259237-aty0vrat	12	24	.	.	.
cord-259237-aty0vrat	13	1	Despite	despite	IN
cord-259237-aty0vrat	13	2	their	-PRON-	PRP$
cord-259237-aty0vrat	13	3	vast	vast	JJ
cord-259237-aty0vrat	13	4	diversity	diversity	NN
cord-259237-aty0vrat	13	5	,	,	,
cord-259237-aty0vrat	13	6	animal	animal	NN
cord-259237-aty0vrat	13	7	viruses	virus	NNS
cord-259237-aty0vrat	13	8	can	can	MD
cord-259237-aty0vrat	13	9	be	be	VB
cord-259237-aty0vrat	13	10	simply	simply	RB
cord-259237-aty0vrat	13	11	divided	divide	VBN
cord-259237-aty0vrat	13	12	into	into	IN
cord-259237-aty0vrat	13	13	two	two	CD
cord-259237-aty0vrat	13	14	categories	category	NNS
cord-259237-aty0vrat	13	15	:	:	:
cord-259237-aty0vrat	13	16	non	non	JJ
cord-259237-aty0vrat	13	17	-	-	JJ
cord-259237-aty0vrat	13	18	enveloped	enveloped	JJ
cord-259237-aty0vrat	13	19	viruses	virus	NNS
cord-259237-aty0vrat	13	20	and	and	CC
cord-259237-aty0vrat	13	21	enveloped	envelop	VBN
cord-259237-aty0vrat	13	22	viruses	virus	NNS
cord-259237-aty0vrat	13	23	[	[	-LRB-
cord-259237-aty0vrat	13	24	1	1	CD
cord-259237-aty0vrat	13	25	]	]	-RRB-
cord-259237-aty0vrat	13	26	.	.	.
cord-259237-aty0vrat	14	1	While	while	IN
cord-259237-aty0vrat	14	2	non	non	JJ
cord-259237-aty0vrat	14	3	-	-	JJ
cord-259237-aty0vrat	14	4	enveloped	enveloped	JJ
cord-259237-aty0vrat	14	5	viruses	virus	NNS
cord-259237-aty0vrat	14	6	are	be	VBP
cord-259237-aty0vrat	14	7	wrapped	wrap	VBN
cord-259237-aty0vrat	14	8	with	with	IN
cord-259237-aty0vrat	14	9	naked	naked	JJ
cord-259237-aty0vrat	14	10	shells	shell	NNS
cord-259237-aty0vrat	14	11	made	make	VBN
cord-259237-aty0vrat	14	12	of	of	IN
cord-259237-aty0vrat	14	13	viral	viral	JJ
cord-259237-aty0vrat	14	14	capsid	capsid	NN
cord-259237-aty0vrat	14	15	proteins	protein	NNS
cord-259237-aty0vrat	14	16	,	,	,
cord-259237-aty0vrat	14	17	enveloped	envelop	VBD
cord-259237-aty0vrat	14	18	viruses	virus	NNS
cord-259237-aty0vrat	14	19	are	be	VBP
cord-259237-aty0vrat	14	20	covered	cover	VBN
cord-259237-aty0vrat	14	21	with	with	IN
cord-259237-aty0vrat	14	22	a	a	DT
cord-259237-aty0vrat	14	23	lipid	lipid	NN
cord-259237-aty0vrat	14	24	-	-	HYPH
cord-259237-aty0vrat	14	25	bilayer	bilayer	NN
cord-259237-aty0vrat	14	26	,	,	,
cord-259237-aty0vrat	14	27	which	which	WDT
cord-259237-aty0vrat	14	28	is	be	VBZ
cord-259237-aty0vrat	14	29	called	call	VBN
cord-259237-aty0vrat	14	30	a	a	DT
cord-259237-aty0vrat	14	31	viral	viral	JJ
cord-259237-aty0vrat	14	32	envelope	envelope	NN
cord-259237-aty0vrat	14	33	.	.	.
cord-259237-aty0vrat	15	1	The	the	DT
cord-259237-aty0vrat	15	2	viral	viral	JJ
cord-259237-aty0vrat	15	3	envelope	envelope	NN
cord-259237-aty0vrat	15	4	is	be	VBZ
cord-259237-aty0vrat	15	5	obtained	obtain	VBN
cord-259237-aty0vrat	15	6	from	from	IN
cord-259237-aty0vrat	15	7	progenitor	progenitor	NN
cord-259237-aty0vrat	15	8	host	host	NN
cord-259237-aty0vrat	15	9	cells	cell	NNS
cord-259237-aty0vrat	15	10	during	during	IN
cord-259237-aty0vrat	15	11	the	the	DT
cord-259237-aty0vrat	15	12	budding	budding	NN
cord-259237-aty0vrat	15	13	process	process	NN
cord-259237-aty0vrat	15	14	,	,	,
cord-259237-aty0vrat	15	15	which	which	WDT
cord-259237-aty0vrat	15	16	can	can	MD
cord-259237-aty0vrat	15	17	be	be	VB
cord-259237-aty0vrat	15	18	a	a	DT
cord-259237-aty0vrat	15	19	portion	portion	NN
cord-259237-aty0vrat	15	20	of	of	IN
cord-259237-aty0vrat	15	21	plasma	plasma	NN
cord-259237-aty0vrat	15	22	membrane	membrane	NN
cord-259237-aty0vrat	15	23	or	or	CC
cord-259237-aty0vrat	15	24	intracellular	intracellular	JJ
cord-259237-aty0vrat	15	25	membrane	membrane	NN
cord-259237-aty0vrat	15	26	.	.	.
cord-259237-aty0vrat	16	1	On	on	IN
cord-259237-aty0vrat	16	2	the	the	DT
cord-259237-aty0vrat	16	3	surface	surface	NN
cord-259237-aty0vrat	16	4	of	of	IN
cord-259237-aty0vrat	16	5	the	the	DT
cord-259237-aty0vrat	16	6	enveloped	envelop	VBN
cord-259237-aty0vrat	16	7	viruses	virus	NNS
cord-259237-aty0vrat	16	8	,	,	,
cord-259237-aty0vrat	16	9	there	there	EX
cord-259237-aty0vrat	16	10	are	be	VBP
cord-259237-aty0vrat	16	11	peplomers	peplomer	NNS
cord-259237-aty0vrat	16	12	that	that	DT
cord-259237-aty0vrat	16	13	project	project	VBP
cord-259237-aty0vrat	16	14	from	from	IN
cord-259237-aty0vrat	16	15	the	the	DT
cord-259237-aty0vrat	16	16	viral	viral	JJ
cord-259237-aty0vrat	16	17	envelope	envelope	NN
cord-259237-aty0vrat	16	18	,	,	,
cord-259237-aty0vrat	16	19	and	and	CC
cord-259237-aty0vrat	16	20	play	play	VB
cord-259237-aty0vrat	16	21	a	a	DT
cord-259237-aty0vrat	16	22	critical	critical	JJ
cord-259237-aty0vrat	16	23	role	role	NN
cord-259237-aty0vrat	16	24	in	in	IN
cord-259237-aty0vrat	16	25	viral	viral	JJ
cord-259237-aty0vrat	16	26	infection	infection	NN
cord-259237-aty0vrat	16	27	.	.	.
cord-259237-aty0vrat	17	1	These	these	DT
cord-259237-aty0vrat	17	2	peplomers	peplomer	NNS
cord-259237-aty0vrat	17	3	are	be	VBP
cord-259237-aty0vrat	17	4	also	also	RB
cord-259237-aty0vrat	17	5	described	describe	VBN
cord-259237-aty0vrat	17	6	as	as	IN
cord-259237-aty0vrat	17	7	spikes	spike	NNS
cord-259237-aty0vrat	17	8	,	,	,
cord-259237-aty0vrat	17	9	which	which	WDT
cord-259237-aty0vrat	17	10	are	be	VBP
cord-259237-aty0vrat	17	11	made	make	VBN
cord-259237-aty0vrat	17	12	of	of	IN
cord-259237-aty0vrat	17	13	viral	viral	JJ
cord-259237-aty0vrat	17	14	envelope	envelope	NN
cord-259237-aty0vrat	17	15	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	17	16	.	.	.
cord-259237-aty0vrat	18	1	Envelope	envelope	NN
cord-259237-aty0vrat	18	2	spikes	spike	NNS
cord-259237-aty0vrat	18	3	serve	serve	VBP
cord-259237-aty0vrat	18	4	to	to	TO
cord-259237-aty0vrat	18	5	identify	identify	VB
cord-259237-aty0vrat	18	6	and	and	CC
cord-259237-aty0vrat	18	7	bind	bind	VB
cord-259237-aty0vrat	18	8	to	to	IN
cord-259237-aty0vrat	18	9	viral	viral	JJ
cord-259237-aty0vrat	18	10	receptors	receptor	NNS
cord-259237-aty0vrat	18	11	on	on	IN
cord-259237-aty0vrat	18	12	the	the	DT
cord-259237-aty0vrat	18	13	host	host	NN
cord-259237-aty0vrat	18	14	cell	cell	NN
cord-259237-aty0vrat	18	15	surface	surface	NN
cord-259237-aty0vrat	18	16	,	,	,
cord-259237-aty0vrat	18	17	allowing	allow	VBG
cord-259237-aty0vrat	18	18	viral	viral	JJ
cord-259237-aty0vrat	18	19	entry	entry	NN
cord-259237-aty0vrat	18	20	into	into	IN
cord-259237-aty0vrat	18	21	cells	cell	NNS
cord-259237-aty0vrat	18	22	and	and	CC
cord-259237-aty0vrat	18	23	the	the	DT
cord-259237-aty0vrat	18	24	initiation	initiation	NN
cord-259237-aty0vrat	18	25	of	of	IN
cord-259237-aty0vrat	18	26	infection	infection	NN
cord-259237-aty0vrat	18	27	by	by	IN
cord-259237-aty0vrat	18	28	mediating	mediate	VBG
cord-259237-aty0vrat	18	29	virus	virus	NN
cord-259237-aty0vrat	18	30	-	-	HYPH
cord-259237-aty0vrat	18	31	cell	cell	NN
cord-259237-aty0vrat	18	32	fusion	fusion	NN
cord-259237-aty0vrat	18	33	.	.	.
cord-259237-aty0vrat	19	1	Thus	thus	RB
cord-259237-aty0vrat	19	2	,	,	,
cord-259237-aty0vrat	19	3	the	the	DT
cord-259237-aty0vrat	19	4	infectivity	infectivity	NN
cord-259237-aty0vrat	19	5	of	of	IN
cord-259237-aty0vrat	19	6	enveloped	envelop	VBN
cord-259237-aty0vrat	19	7	viruses	virus	NNS
cord-259237-aty0vrat	19	8	is	be	VBZ
cord-259237-aty0vrat	19	9	absolutely	absolutely	RB
cord-259237-aty0vrat	19	10	dependent	dependent	JJ
cord-259237-aty0vrat	19	11	on	on	IN
cord-259237-aty0vrat	19	12	the	the	DT
cord-259237-aty0vrat	19	13	integrity	integrity	NN
cord-259237-aty0vrat	19	14	of	of	IN
cord-259237-aty0vrat	19	15	the	the	DT
cord-259237-aty0vrat	19	16	viral	viral	JJ
cord-259237-aty0vrat	19	17	envelope	envelope	NN
cord-259237-aty0vrat	19	18	,	,	,
cord-259237-aty0vrat	19	19	and	and	CC
cord-259237-aty0vrat	19	20	the	the	DT
cord-259237-aty0vrat	19	21	functionality	functionality	NN
cord-259237-aty0vrat	19	22	of	of	IN
cord-259237-aty0vrat	19	23	the	the	DT
cord-259237-aty0vrat	19	24	viral	viral	JJ
cord-259237-aty0vrat	19	25	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	19	26	found	find	VBN
cord-259237-aty0vrat	19	27	therein	therein	RB
cord-259237-aty0vrat	19	28	.	.	.
cord-259237-aty0vrat	20	1	Enveloped	envelop	VBN
cord-259237-aty0vrat	20	2	viruses	virus	NNS
cord-259237-aty0vrat	20	3	are	be	VBP
cord-259237-aty0vrat	20	4	more	more	RBR
cord-259237-aty0vrat	20	5	stable	stable	JJ
cord-259237-aty0vrat	20	6	than	than	IN
cord-259237-aty0vrat	20	7	non	non	JJ
cord-259237-aty0vrat	20	8	-	-	JJ
cord-259237-aty0vrat	20	9	enveloped	enveloped	JJ
cord-259237-aty0vrat	20	10	viruses	virus	NNS
cord-259237-aty0vrat	20	11	under	under	IN
cord-259237-aty0vrat	20	12	physiological	physiological	JJ
cord-259237-aty0vrat	20	13	conditions	condition	NNS
cord-259237-aty0vrat	20	14	,	,	,
cord-259237-aty0vrat	20	15	at	at	IN
cord-259237-aty0vrat	20	16	the	the	DT
cord-259237-aty0vrat	20	17	expense	expense	NN
cord-259237-aty0vrat	20	18	of	of	IN
cord-259237-aty0vrat	20	19	their	-PRON-	PRP$
cord-259237-aty0vrat	20	20	sensitivity	sensitivity	NN
cord-259237-aty0vrat	20	21	to	to	IN
cord-259237-aty0vrat	20	22	high	high	JJ
cord-259237-aty0vrat	20	23	-	-	HYPH
cord-259237-aty0vrat	20	24	temperature	temperature	NN
cord-259237-aty0vrat	20	25	,	,	,
cord-259237-aty0vrat	20	26	low	low	JJ
cord-259237-aty0vrat	20	27	-	-	HYPH
cord-259237-aty0vrat	20	28	pH	ph	NN
cord-259237-aty0vrat	20	29	,	,	,
cord-259237-aty0vrat	20	30	desiccation	desiccation	NN
cord-259237-aty0vrat	20	31	,	,	,
cord-259237-aty0vrat	20	32	or	or	CC
cord-259237-aty0vrat	20	33	detergent	detergent	NN
cord-259237-aty0vrat	20	34	-	-	HYPH
cord-259237-aty0vrat	20	35	treatment	treatment	NN
cord-259237-aty0vrat	20	36	,	,	,
cord-259237-aty0vrat	20	37	which	which	WDT
cord-259237-aty0vrat	20	38	limits	limit	VBZ
cord-259237-aty0vrat	20	39	their	-PRON-	PRP$
cord-259237-aty0vrat	20	40	ability	ability	NN
cord-259237-aty0vrat	20	41	to	to	TO
cord-259237-aty0vrat	20	42	withstand	withstand	VB
cord-259237-aty0vrat	20	43	severe	severe	JJ
cord-259237-aty0vrat	20	44	environments	environment	NNS
cord-259237-aty0vrat	20	45	[	[	-LRB-
cord-259237-aty0vrat	20	46	2	2	CD
cord-259237-aty0vrat	20	47	]	]	-RRB-
cord-259237-aty0vrat	20	48	.	.	.
cord-259237-aty0vrat	21	1	The	the	DT
cord-259237-aty0vrat	21	2	entry	entry	NN
cord-259237-aty0vrat	21	3	of	of	IN
cord-259237-aty0vrat	21	4	enveloped	envelop	VBN
cord-259237-aty0vrat	21	5	viruses	virus	NNS
cord-259237-aty0vrat	21	6	requires	require	VBZ
cord-259237-aty0vrat	21	7	the	the	DT
cord-259237-aty0vrat	21	8	formation	formation	NN
cord-259237-aty0vrat	21	9	of	of	IN
cord-259237-aty0vrat	21	10	a	a	DT
cord-259237-aty0vrat	21	11	fusion	fusion	NN
cord-259237-aty0vrat	21	12	pore	pore	NN
cord-259237-aty0vrat	21	13	between	between	IN
cord-259237-aty0vrat	21	14	the	the	DT
cord-259237-aty0vrat	21	15	viral	viral	JJ
cord-259237-aty0vrat	21	16	envelope	envelope	NN
cord-259237-aty0vrat	21	17	and	and	CC
cord-259237-aty0vrat	21	18	the	the	DT
cord-259237-aty0vrat	21	19	cell	cell	NN
cord-259237-aty0vrat	21	20	membrane	membrane	NN
cord-259237-aty0vrat	21	21	,	,	,
cord-259237-aty0vrat	21	22	through	through	IN
cord-259237-aty0vrat	21	23	which	which	WDT
cord-259237-aty0vrat	21	24	the	the	DT
cord-259237-aty0vrat	21	25	viral	viral	JJ
cord-259237-aty0vrat	21	26	genome	genome	NN
cord-259237-aty0vrat	21	27	is	be	VBZ
cord-259237-aty0vrat	21	28	released	release	VBN
cord-259237-aty0vrat	21	29	into	into	IN
cord-259237-aty0vrat	21	30	the	the	DT
cord-259237-aty0vrat	21	31	cell	cell	NN
cord-259237-aty0vrat	21	32	.	.	.
cord-259237-aty0vrat	22	1	This	this	DT
cord-259237-aty0vrat	22	2	fusion	fusion	NN
cord-259237-aty0vrat	22	3	process	process	NN
cord-259237-aty0vrat	22	4	is	be	VBZ
cord-259237-aty0vrat	22	5	triggered	trigger	VBN
cord-259237-aty0vrat	22	6	by	by	IN
cord-259237-aty0vrat	22	7	interactions	interaction	NNS
cord-259237-aty0vrat	22	8	between	between	IN
cord-259237-aty0vrat	22	9	viral	viral	JJ
cord-259237-aty0vrat	22	10	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	22	11	on	on	IN
cord-259237-aty0vrat	22	12	the	the	DT
cord-259237-aty0vrat	22	13	viral	viral	JJ
cord-259237-aty0vrat	22	14	envelope	envelope	NN
cord-259237-aty0vrat	22	15	and	and	CC
cord-259237-aty0vrat	22	16	viral	viral	JJ
cord-259237-aty0vrat	22	17	receptors	receptor	NNS
cord-259237-aty0vrat	22	18	on	on	IN
cord-259237-aty0vrat	22	19	the	the	DT
cord-259237-aty0vrat	22	20	cell	cell	NN
cord-259237-aty0vrat	22	21	surface	surface	NN
cord-259237-aty0vrat	22	22	,	,	,
cord-259237-aty0vrat	22	23	which	which	WDT
cord-259237-aty0vrat	22	24	can	can	MD
cord-259237-aty0vrat	22	25	occur	occur	VB
cord-259237-aty0vrat	22	26	directly	directly	RB
cord-259237-aty0vrat	22	27	at	at	IN
cord-259237-aty0vrat	22	28	the	the	DT
cord-259237-aty0vrat	22	29	plasma	plasma	NN
cord-259237-aty0vrat	22	30	membrane	membrane	NN
cord-259237-aty0vrat	22	31	at	at	IN
cord-259237-aty0vrat	22	32	neutral	neutral	JJ
cord-259237-aty0vrat	22	33	pH	pH	NNP
cord-259237-aty0vrat	22	34	or	or	CC
cord-259237-aty0vrat	22	35	in	in	IN
cord-259237-aty0vrat	22	36	endocytic	endocytic	JJ
cord-259237-aty0vrat	22	37	compartments	compartment	NNS
cord-259237-aty0vrat	22	38	at	at	IN
cord-259237-aty0vrat	22	39	either	either	CC
cord-259237-aty0vrat	22	40	low	low	JJ
cord-259237-aty0vrat	22	41	or	or	CC
cord-259237-aty0vrat	22	42	neutral	neutral	JJ
cord-259237-aty0vrat	22	43	pH	pH	NNP
cord-259237-aty0vrat	22	44	[	[	-LRB-
cord-259237-aty0vrat	22	45	3	3	CD
cord-259237-aty0vrat	22	46	]	]	-RRB-
cord-259237-aty0vrat	22	47	.	.	.
cord-259237-aty0vrat	23	1	In	in	IN
cord-259237-aty0vrat	23	2	addition	addition	NN
cord-259237-aty0vrat	23	3	,	,	,
cord-259237-aty0vrat	23	4	enveloped	envelop	VBN
cord-259237-aty0vrat	23	5	viruses	virus	NNS
cord-259237-aty0vrat	23	6	can	can	MD
cord-259237-aty0vrat	23	7	also	also	RB
cord-259237-aty0vrat	23	8	enter	enter	VB
cord-259237-aty0vrat	23	9	cells	cell	NNS
cord-259237-aty0vrat	23	10	through	through	IN
cord-259237-aty0vrat	23	11	direct	direct	JJ
cord-259237-aty0vrat	23	12	cell	cell	NN
cord-259237-aty0vrat	23	13	-	-	HYPH
cord-259237-aty0vrat	23	14	to	to	IN
cord-259237-aty0vrat	23	15	-	-	HYPH
cord-259237-aty0vrat	23	16	cell	cell	NN
cord-259237-aty0vrat	23	17	contacts	contact	NNS
cord-259237-aty0vrat	23	18	via	via	IN
cord-259237-aty0vrat	23	19	virological	virological	JJ
cord-259237-aty0vrat	23	20	Glycosylation	glycosylation	NN
cord-259237-aty0vrat	23	21	,	,	,
cord-259237-aty0vrat	23	22	which	which	WDT
cord-259237-aty0vrat	23	23	is	be	VBZ
cord-259237-aty0vrat	23	24	one	one	CD
cord-259237-aty0vrat	23	25	of	of	IN
cord-259237-aty0vrat	23	26	the	the	DT
cord-259237-aty0vrat	23	27	most	most	RBS
cord-259237-aty0vrat	23	28	common	common	JJ
cord-259237-aty0vrat	23	29	post	post	JJ
cord-259237-aty0vrat	23	30	-	-	JJ
cord-259237-aty0vrat	23	31	translational	translational	JJ
cord-259237-aty0vrat	23	32	modifications	modification	NNS
cord-259237-aty0vrat	23	33	in	in	IN
cord-259237-aty0vrat	23	34	eukaryotic	eukaryotic	JJ
cord-259237-aty0vrat	23	35	cells	cell	NNS
cord-259237-aty0vrat	23	36	,	,	,
cord-259237-aty0vrat	23	37	is	be	VBZ
cord-259237-aty0vrat	23	38	required	require	VBN
cord-259237-aty0vrat	23	39	for	for	IN
cord-259237-aty0vrat	23	40	protein	protein	NN
cord-259237-aty0vrat	23	41	folding	folding	NN
cord-259237-aty0vrat	23	42	and	and	CC
cord-259237-aty0vrat	23	43	maintaining	maintain	VBG
cord-259237-aty0vrat	23	44	protein	protein	NN
cord-259237-aty0vrat	23	45	structure	structure	NN
cord-259237-aty0vrat	23	46	.	.	.
cord-259237-aty0vrat	24	1	Viruses	virus	NNS
cord-259237-aty0vrat	24	2	have	have	VBP
cord-259237-aty0vrat	24	3	taken	take	VBN
cord-259237-aty0vrat	24	4	advantage	advantage	NN
cord-259237-aty0vrat	24	5	of	of	IN
cord-259237-aty0vrat	24	6	this	this	DT
cord-259237-aty0vrat	24	7	benefit	benefit	NN
cord-259237-aty0vrat	24	8	at	at	IN
cord-259237-aty0vrat	24	9	nearly	nearly	RB
cord-259237-aty0vrat	24	10	every	every	DT
cord-259237-aty0vrat	24	11	step	step	NN
cord-259237-aty0vrat	24	12	of	of	IN
cord-259237-aty0vrat	24	13	the	the	DT
cord-259237-aty0vrat	24	14	viral	viral	JJ
cord-259237-aty0vrat	24	15	life	life	NN
cord-259237-aty0vrat	24	16	cycle	cycle	NN
cord-259237-aty0vrat	24	17	[	[	-LRB-
cord-259237-aty0vrat	24	18	12	12	CD
cord-259237-aty0vrat	24	19	]	]	-RRB-
cord-259237-aty0vrat	24	20	.	.	.
cord-259237-aty0vrat	25	1	N	n	NN
cord-259237-aty0vrat	25	2	-	-	HYPH
cord-259237-aty0vrat	25	3	glycosylation	glycosylation	NN
cord-259237-aty0vrat	25	4	significantly	significantly	RB
cord-259237-aty0vrat	25	5	promotes	promote	VBZ
cord-259237-aty0vrat	25	6	their	-PRON-	PRP$
cord-259237-aty0vrat	25	7	folding	folding	NN
cord-259237-aty0vrat	25	8	and	and	CC
cord-259237-aty0vrat	25	9	solubility	solubility	NN
cord-259237-aty0vrat	25	10	,	,	,
cord-259237-aty0vrat	25	11	enhances	enhance	VBZ
cord-259237-aty0vrat	25	12	subsequent	subsequent	JJ
cord-259237-aty0vrat	25	13	trafficking	trafficking	NN
cord-259237-aty0vrat	25	14	of	of	IN
cord-259237-aty0vrat	25	15	these	these	DT
cord-259237-aty0vrat	25	16	viral	viral	JJ
cord-259237-aty0vrat	25	17	proteins	protein	NNS
cord-259237-aty0vrat	25	18	to	to	IN
cord-259237-aty0vrat	25	19	their	-PRON-	PRP$
cord-259237-aty0vrat	25	20	destinations	destination	NNS
cord-259237-aty0vrat	25	21	,	,	,
cord-259237-aty0vrat	25	22	and	and	CC
cord-259237-aty0vrat	25	23	ensures	ensure	VBZ
cord-259237-aty0vrat	25	24	that	that	IN
cord-259237-aty0vrat	25	25	they	-PRON-	PRP
cord-259237-aty0vrat	25	26	are	be	VBP
cord-259237-aty0vrat	25	27	properly	properly	RB
cord-259237-aty0vrat	25	28	processed	process	VBN
cord-259237-aty0vrat	25	29	and	and	CC
cord-259237-aty0vrat	25	30	incorporated	incorporate	VBN
cord-259237-aty0vrat	25	31	into	into	IN
cord-259237-aty0vrat	25	32	virions	virion	NNS
cord-259237-aty0vrat	25	33	.	.	.
cord-259237-aty0vrat	26	1	Nevertheless	nevertheless	RB
cord-259237-aty0vrat	26	2	,	,	,
cord-259237-aty0vrat	26	3	glycosylation	glycosylation	NN
cord-259237-aty0vrat	26	4	can	can	MD
cord-259237-aty0vrat	26	5	have	have	VB
cord-259237-aty0vrat	26	6	distinct	distinct	JJ
cord-259237-aty0vrat	26	7	effects	effect	NNS
cord-259237-aty0vrat	26	8	that	that	WDT
cord-259237-aty0vrat	26	9	are	be	VBP
cord-259237-aty0vrat	26	10	both	both	DT
cord-259237-aty0vrat	26	11	advantageous	advantageous	JJ
cord-259237-aty0vrat	26	12	and	and	CC
cord-259237-aty0vrat	26	13	detrimental	detrimental	JJ
cord-259237-aty0vrat	26	14	to	to	IN
cord-259237-aty0vrat	26	15	viral	viral	JJ
cord-259237-aty0vrat	26	16	fitness	fitness	NN
cord-259237-aty0vrat	26	17	.	.	.
cord-259237-aty0vrat	27	1	For	for	IN
cord-259237-aty0vrat	27	2	example	example	NN
cord-259237-aty0vrat	27	3	,	,	,
cord-259237-aty0vrat	27	4	if	if	IN
cord-259237-aty0vrat	27	5	glycosylation	glycosylation	NN
cord-259237-aty0vrat	27	6	occurs	occur	VBZ
cord-259237-aty0vrat	27	7	close	close	RB
cord-259237-aty0vrat	27	8	to	to	IN
cord-259237-aty0vrat	27	9	the	the	DT
cord-259237-aty0vrat	27	10	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	27	11	processing	processing	NN
cord-259237-aty0vrat	27	12	sites	site	NNS
cord-259237-aty0vrat	27	13	,	,	,
cord-259237-aty0vrat	27	14	it	-PRON-	PRP
cord-259237-aty0vrat	27	15	may	may	MD
cord-259237-aty0vrat	27	16	block	block	VB
cord-259237-aty0vrat	27	17	the	the	DT
cord-259237-aty0vrat	27	18	precursor	precursor	NN
cord-259237-aty0vrat	27	19	cleavage	cleavage	NN
cord-259237-aty0vrat	27	20	by	by	IN
cord-259237-aty0vrat	27	21	proteases	protease	NNS
cord-259237-aty0vrat	27	22	and	and	CC
cord-259237-aty0vrat	27	23	inhibit	inhibit	VB
cord-259237-aty0vrat	27	24	viral	viral	JJ
cord-259237-aty0vrat	27	25	infection	infection	NN
cord-259237-aty0vrat	27	26	[	[	-LRB-
cord-259237-aty0vrat	27	27	13	13	CD
cord-259237-aty0vrat	27	28	]	]	-RRB-
cord-259237-aty0vrat	27	29	;	;	:
cord-259237-aty0vrat	27	30	if	if	IN
cord-259237-aty0vrat	27	31	glycosylation	glycosylation	NN
cord-259237-aty0vrat	27	32	occurs	occur	VBZ
cord-259237-aty0vrat	27	33	adjacent	adjacent	JJ
cord-259237-aty0vrat	27	34	to	to	IN
cord-259237-aty0vrat	27	35	the	the	DT
cord-259237-aty0vrat	27	36	receptor	receptor	NN
cord-259237-aty0vrat	27	37	-	-	HYPH
cord-259237-aty0vrat	27	38	binding	bind	VBG
cord-259237-aty0vrat	27	39	site	site	NN
cord-259237-aty0vrat	27	40	,	,	,
cord-259237-aty0vrat	27	41	it	-PRON-	PRP
cord-259237-aty0vrat	27	42	may	may	MD
cord-259237-aty0vrat	27	43	enhance	enhance	VB
cord-259237-aty0vrat	27	44	the	the	DT
cord-259237-aty0vrat	27	45	binding	bind	VBG
cord-259237-aty0vrat	27	46	affinity	affinity	NN
cord-259237-aty0vrat	27	47	and	and	CC
cord-259237-aty0vrat	27	48	promote	promote	VB
cord-259237-aty0vrat	27	49	viral	viral	JJ
cord-259237-aty0vrat	27	50	infection	infection	NN
cord-259237-aty0vrat	27	51	[	[	-LRB-
cord-259237-aty0vrat	27	52	14	14	CD
cord-259237-aty0vrat	27	53	,	,	,
cord-259237-aty0vrat	27	54	15	15	CD
cord-259237-aty0vrat	27	55	]	]	-RRB-
cord-259237-aty0vrat	27	56	.	.	.
cord-259237-aty0vrat	28	1	In	in	IN
cord-259237-aty0vrat	28	2	addition	addition	NN
cord-259237-aty0vrat	28	3	,	,	,
cord-259237-aty0vrat	28	4	the	the	DT
cord-259237-aty0vrat	28	5	high	high	JJ
cord-259237-aty0vrat	28	6	density	density	NN
cord-259237-aty0vrat	28	7	of	of	IN
cord-259237-aty0vrat	28	8	glycans	glycan	NNS
cord-259237-aty0vrat	28	9	on	on	IN
cord-259237-aty0vrat	28	10	virions	virion	NNS
cord-259237-aty0vrat	28	11	may	may	MD
cord-259237-aty0vrat	28	12	form	form	VB
cord-259237-aty0vrat	28	13	a	a	DT
cord-259237-aty0vrat	28	14	shield	shield	NN
cord-259237-aty0vrat	28	15	to	to	TO
cord-259237-aty0vrat	28	16	impede	impede	VB
cord-259237-aty0vrat	28	17	antibody	antibody	NN
cord-259237-aty0vrat	28	18	attack	attack	NN
cord-259237-aty0vrat	28	19	and	and	CC
cord-259237-aty0vrat	28	20	promote	promote	VB
cord-259237-aty0vrat	28	21	immune	immune	JJ
cord-259237-aty0vrat	28	22	evasion	evasion	NN
cord-259237-aty0vrat	28	23	.	.	.
cord-259237-aty0vrat	29	1	However	however	RB
cord-259237-aty0vrat	29	2	,	,	,
cord-259237-aty0vrat	29	3	these	these	DT
cord-259237-aty0vrat	29	4	glycans	glycan	NNS
cord-259237-aty0vrat	29	5	can	can	MD
cord-259237-aty0vrat	29	6	also	also	RB
cord-259237-aty0vrat	29	7	become	become	VB
cord-259237-aty0vrat	29	8	epitopes	epitope	NNS
cord-259237-aty0vrat	29	9	for	for	IN
cord-259237-aty0vrat	29	10	stimulating	stimulate	VBG
cord-259237-aty0vrat	29	11	neutralizing	neutralize	VBG
cord-259237-aty0vrat	29	12	antibodies	antibody	NNS
cord-259237-aty0vrat	29	13	and	and	CC
cord-259237-aty0vrat	29	14	the	the	DT
cord-259237-aty0vrat	29	15	innate	innate	JJ
cord-259237-aty0vrat	29	16	immune	immune	JJ
cord-259237-aty0vrat	29	17	response	response	NN
cord-259237-aty0vrat	29	18	,	,	,
cord-259237-aty0vrat	29	19	making	make	VBG
cord-259237-aty0vrat	29	20	viruses	virus	NNS
cord-259237-aty0vrat	29	21	more	more	RBR
cord-259237-aty0vrat	29	22	vulnerable	vulnerable	JJ
cord-259237-aty0vrat	29	23	to	to	IN
cord-259237-aty0vrat	29	24	immune	immune	JJ
cord-259237-aty0vrat	29	25	clearance	clearance	NN
cord-259237-aty0vrat	29	26	[	[	-LRB-
cord-259237-aty0vrat	29	27	16	16	CD
cord-259237-aty0vrat	29	28	]	]	-RRB-
cord-259237-aty0vrat	29	29	.	.	.
cord-259237-aty0vrat	30	1	Thus	thus	RB
cord-259237-aty0vrat	30	2	,	,	,
cord-259237-aty0vrat	30	3	there	there	EX
cord-259237-aty0vrat	30	4	are	be	VBP
cord-259237-aty0vrat	30	5	multiple	multiple	JJ
cord-259237-aty0vrat	30	6	selective	selective	JJ
cord-259237-aty0vrat	30	7	pressures	pressure	NNS
cord-259237-aty0vrat	30	8	on	on	IN
cord-259237-aty0vrat	30	9	viral	viral	JJ
cord-259237-aty0vrat	30	10	envelope	envelope	NN
cord-259237-aty0vrat	30	11	glycosylation	glycosylation	NN
cord-259237-aty0vrat	30	12	that	that	WDT
cord-259237-aty0vrat	30	13	can	can	MD
cord-259237-aty0vrat	30	14	influence	influence	VB
cord-259237-aty0vrat	30	15	the	the	DT
cord-259237-aty0vrat	30	16	pattern	pattern	NN
cord-259237-aty0vrat	30	17	of	of	IN
cord-259237-aty0vrat	30	18	glycosylation	glycosylation	NN
cord-259237-aty0vrat	30	19	in	in	IN
cord-259237-aty0vrat	30	20	order	order	NN
cord-259237-aty0vrat	30	21	to	to	TO
cord-259237-aty0vrat	30	22	achieve	achieve	VB
cord-259237-aty0vrat	30	23	the	the	DT
cord-259237-aty0vrat	30	24	optimal	optimal	JJ
cord-259237-aty0vrat	30	25	fitness	fitness	NN
cord-259237-aty0vrat	30	26	in	in	IN
cord-259237-aty0vrat	30	27	their	-PRON-	PRP$
cord-259237-aty0vrat	30	28	hosts	host	NNS
cord-259237-aty0vrat	30	29	[	[	-LRB-
cord-259237-aty0vrat	30	30	17	17	CD
cord-259237-aty0vrat	30	31	]	]	-RRB-
cord-259237-aty0vrat	30	32	.	.	.
cord-259237-aty0vrat	31	1	Viruses	virus	NNS
cord-259237-aty0vrat	31	2	are	be	VBP
cord-259237-aty0vrat	31	3	obligate	obligate	VBN
cord-259237-aty0vrat	31	4	intracellular	intracellular	JJ
cord-259237-aty0vrat	31	5	parasites	parasite	NNS
cord-259237-aty0vrat	31	6	,	,	,
cord-259237-aty0vrat	31	7	and	and	CC
cord-259237-aty0vrat	31	8	their	-PRON-	PRP$
cord-259237-aty0vrat	31	9	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	31	10	biosynthesis	biosynthesis	NN
cord-259237-aty0vrat	31	11	and	and	CC
cord-259237-aty0vrat	31	12	modification	modification	NN
cord-259237-aty0vrat	31	13	rely	rely	VBP
cord-259237-aty0vrat	31	14	entirely	entirely	RB
cord-259237-aty0vrat	31	15	on	on	IN
cord-259237-aty0vrat	31	16	host	host	NN
cord-259237-aty0vrat	31	17	cell	cell	NN
cord-259237-aty0vrat	31	18	machinery	machinery	NN
cord-259237-aty0vrat	31	19	in	in	IN
cord-259237-aty0vrat	31	20	the	the	DT
cord-259237-aty0vrat	31	21	secretory	secretory	JJ
cord-259237-aty0vrat	31	22	pathway	pathway	NN
cord-259237-aty0vrat	31	23	.	.	.
cord-259237-aty0vrat	32	1	Therefore	therefore	RB
cord-259237-aty0vrat	32	2	,	,	,
cord-259237-aty0vrat	32	3	viral	viral	JJ
cord-259237-aty0vrat	32	4	and	and	CC
cord-259237-aty0vrat	32	5	host	host	NN
cord-259237-aty0vrat	32	6	proteins	protein	NNS
cord-259237-aty0vrat	32	7	are	be	VBP
cord-259237-aty0vrat	32	8	glycosylated	glycosylate	VBN
cord-259237-aty0vrat	32	9	in	in	IN
cord-259237-aty0vrat	32	10	a	a	DT
cord-259237-aty0vrat	32	11	similar	similar	JJ
cord-259237-aty0vrat	32	12	manner	manner	NN
cord-259237-aty0vrat	32	13	by	by	IN
cord-259237-aty0vrat	32	14	the	the	DT
cord-259237-aty0vrat	32	15	same	same	JJ
cord-259237-aty0vrat	32	16	mechanism	mechanism	NN
cord-259237-aty0vrat	32	17	.	.	.
cord-259237-aty0vrat	33	1	Although	although	IN
cord-259237-aty0vrat	33	2	glycans	glycan	NNS
cord-259237-aty0vrat	33	3	can	can	MD
cord-259237-aty0vrat	33	4	be	be	VB
cord-259237-aty0vrat	33	5	attached	attach	VBN
cord-259237-aty0vrat	33	6	to	to	IN
cord-259237-aty0vrat	33	7	polypeptide	polypeptide	NN
cord-259237-aty0vrat	33	8	structures	structure	NNS
cord-259237-aty0vrat	33	9	via	via	IN
cord-259237-aty0vrat	33	10	several	several	JJ
cord-259237-aty0vrat	33	11	different	different	JJ
cord-259237-aty0vrat	33	12	mechanisms	mechanism	NNS
cord-259237-aty0vrat	33	13	,	,	,
cord-259237-aty0vrat	33	14	asparagine	asparagine	NN
cord-259237-aty0vrat	33	15	N	n	CD
cord-259237-aty0vrat	33	16	-	-	HYPH
cord-259237-aty0vrat	33	17	linked	link	VBN
cord-259237-aty0vrat	33	18	glycosylation	glycosylation	NN
cord-259237-aty0vrat	33	19	represents	represent	VBZ
cord-259237-aty0vrat	33	20	a	a	DT
cord-259237-aty0vrat	33	21	fundamental	fundamental	JJ
cord-259237-aty0vrat	33	22	and	and	CC
cord-259237-aty0vrat	33	23	well	well	RB
cord-259237-aty0vrat	33	24	characterized	characterize	VBN
cord-259237-aty0vrat	33	25	post	post	JJ
cord-259237-aty0vrat	33	26	-	-	JJ
cord-259237-aty0vrat	33	27	translational	translational	JJ
cord-259237-aty0vrat	33	28	modification	modification	NN
cord-259237-aty0vrat	33	29	in	in	IN
cord-259237-aty0vrat	33	30	eukaryotic	eukaryotic	JJ
cord-259237-aty0vrat	33	31	organisms	organism	NNS
cord-259237-aty0vrat	33	32	[	[	-LRB-
cord-259237-aty0vrat	33	33	18	18	CD
cord-259237-aty0vrat	33	34	]	]	-RRB-
cord-259237-aty0vrat	33	35	.	.	.
cord-259237-aty0vrat	34	1	N	n	CD
cord-259237-aty0vrat	34	2	-	-	HYPH
cord-259237-aty0vrat	34	3	linked	link	VBN
cord-259237-aty0vrat	34	4	glycosylation	glycosylation	NN
cord-259237-aty0vrat	34	5	starts	start	VBZ
cord-259237-aty0vrat	34	6	from	from	IN
cord-259237-aty0vrat	34	7	the	the	DT
cord-259237-aty0vrat	34	8	membrane	membrane	NN
cord-259237-aty0vrat	34	9	of	of	IN
cord-259237-aty0vrat	34	10	the	the	DT
cord-259237-aty0vrat	34	11	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	34	12	reticulum	reticulum	NN
cord-259237-aty0vrat	34	13	(	(	-LRB-
cord-259237-aty0vrat	34	14	ER	ER	NNP
cord-259237-aty0vrat	34	15	)	)	-RRB-
cord-259237-aty0vrat	34	16	,	,	,
cord-259237-aty0vrat	34	17	where	where	WRB
cord-259237-aty0vrat	34	18	the	the	DT
cord-259237-aty0vrat	34	19	tetradecasaccharide	tetradecasaccharide	NN
cord-259237-aty0vrat	34	20	precursor	precursor	NN
cord-259237-aty0vrat	34	21	is	be	VBZ
cord-259237-aty0vrat	34	22	assembled	assemble	VBN
cord-259237-aty0vrat	34	23	.	.	.
cord-259237-aty0vrat	35	1	This	this	DT
cord-259237-aty0vrat	35	2	precursor	precursor	NN
cord-259237-aty0vrat	35	3	consists	consist	VBZ
cord-259237-aty0vrat	35	4	of	of	IN
cord-259237-aty0vrat	35	5	two	two	CD
cord-259237-aty0vrat	35	6	N	N	NNP
cord-259237-aty0vrat	35	7	-	-	HYPH
cord-259237-aty0vrat	35	8	acetylglucosamine	acetylglucosamine	NNP
cord-259237-aty0vrat	35	9	(	(	-LRB-
cord-259237-aty0vrat	35	10	GlcNAc	GlcNAc	NNP
cord-259237-aty0vrat	35	11	)	)	-RRB-
cord-259237-aty0vrat	35	12	,	,	,
cord-259237-aty0vrat	35	13	nine	nine	CD
cord-259237-aty0vrat	35	14	mannose	mannose	NN
cord-259237-aty0vrat	35	15	(	(	-LRB-
cord-259237-aty0vrat	35	16	Man	Man	NNP
cord-259237-aty0vrat	35	17	,	,	,
cord-259237-aty0vrat	35	18	4	4	CD
cord-259237-aty0vrat	35	19	are	be	VBP
cord-259237-aty0vrat	35	20	α1,2-linked	α1,2-linked	CD
cord-259237-aty0vrat	35	21	)	)	-RRB-
cord-259237-aty0vrat	35	22	,	,	,
cord-259237-aty0vrat	35	23	and	and	CC
cord-259237-aty0vrat	35	24	three	three	CD
cord-259237-aty0vrat	35	25	terminal	terminal	NN
cord-259237-aty0vrat	35	26	glucose	glucose	NN
cord-259237-aty0vrat	35	27	(	(	-LRB-
cord-259237-aty0vrat	35	28	Glc	Glc	NNP
cord-259237-aty0vrat	35	29	)	)	-RRB-
cord-259237-aty0vrat	35	30	residues	residue	NNS
cord-259237-aty0vrat	35	31	distributed	distribute	VBN
cord-259237-aty0vrat	35	32	on	on	IN
cord-259237-aty0vrat	35	33	three	three	CD
cord-259237-aty0vrat	35	34	extended	extended	JJ
cord-259237-aty0vrat	35	35	Man	Man	NNP
cord-259237-aty0vrat	35	36	branches	branch	NNS
cord-259237-aty0vrat	35	37	:	:	:
cord-259237-aty0vrat	35	38	a	a	LS
cord-259237-aty0vrat	35	39	,	,	,
cord-259237-aty0vrat	35	40	b	b	NN
cord-259237-aty0vrat	35	41	,	,	,
cord-259237-aty0vrat	35	42	and	and	CC
cord-259237-aty0vrat	35	43	c	c	LS
cord-259237-aty0vrat	35	44	(	(	-LRB-
cord-259237-aty0vrat	35	45	Glc	Glc	NNP
cord-259237-aty0vrat	35	46	3	3	CD
cord-259237-aty0vrat	35	47	Man	Man	NNP
cord-259237-aty0vrat	35	48	9	9	CD
cord-259237-aty0vrat	35	49	GlcNAc	glcnac	NN
cord-259237-aty0vrat	35	50	2	2	CD
cord-259237-aty0vrat	35	51	)	)	-RRB-
cord-259237-aty0vrat	35	52	(	(	-LRB-
cord-259237-aty0vrat	35	53	Figure	figure	NN
cord-259237-aty0vrat	35	54	1A	1a	NN
cord-259237-aty0vrat	35	55	)	)	-RRB-
cord-259237-aty0vrat	35	56	[	[	-LRB-
cord-259237-aty0vrat	35	57	19	19	CD
cord-259237-aty0vrat	35	58	,	,	,
cord-259237-aty0vrat	35	59	20	20	CD
cord-259237-aty0vrat	35	60	]	]	-RRB-
cord-259237-aty0vrat	35	61	.	.	.
cord-259237-aty0vrat	36	1	When	when	WRB
cord-259237-aty0vrat	36	2	nascent	nascent	JJ
cord-259237-aty0vrat	36	3	polypeptides	polypeptide	NNS
cord-259237-aty0vrat	36	4	enter	enter	VBP
cord-259237-aty0vrat	36	5	the	the	DT
cord-259237-aty0vrat	36	6	ER	ER	NNP
cord-259237-aty0vrat	36	7	lumen	lumen	NN
cord-259237-aty0vrat	36	8	,	,	,
cord-259237-aty0vrat	36	9	the	the	DT
cord-259237-aty0vrat	36	10	precursor	precursor	NN
cord-259237-aty0vrat	36	11	is	be	VBZ
cord-259237-aty0vrat	36	12	en	en	IN
cord-259237-aty0vrat	36	13	bloc	bloc	NNP
cord-259237-aty0vrat	36	14	attached	attach	VBN
cord-259237-aty0vrat	36	15	to	to	IN
cord-259237-aty0vrat	36	16	Asn	Asn	NNP
cord-259237-aty0vrat	36	17	residues	residue	NNS
cord-259237-aty0vrat	36	18	of	of	IN
cord-259237-aty0vrat	36	19	a	a	DT
cord-259237-aty0vrat	36	20	nascent	nascent	JJ
cord-259237-aty0vrat	36	21	polypeptide	polypeptide	NN
cord-259237-aty0vrat	36	22	in	in	IN
cord-259237-aty0vrat	36	23	a	a	DT
cord-259237-aty0vrat	36	24	consensus	consensus	NN
cord-259237-aty0vrat	36	25	Asn	Asn	NNP
cord-259237-aty0vrat	36	26	-	-	HYPH
cord-259237-aty0vrat	36	27	X-(Ser	X-(Ser	NNP
cord-259237-aty0vrat	36	28	/	/	SYM
cord-259237-aty0vrat	36	29	Thr	Thr	NNP
cord-259237-aty0vrat	36	30	)	)	-RRB-
cord-259237-aty0vrat	36	31	motif	motif	NN
cord-259237-aty0vrat	36	32	.	.	.
cord-259237-aty0vrat	37	1	After	after	IN
cord-259237-aty0vrat	37	2	the	the	DT
cord-259237-aty0vrat	37	3	attachment	attachment	NN
cord-259237-aty0vrat	37	4	,	,	,
cord-259237-aty0vrat	37	5	these	these	DT
cord-259237-aty0vrat	37	6	precursors	precursor	NNS
cord-259237-aty0vrat	37	7	are	be	VBP
cord-259237-aty0vrat	37	8	processed	process	VBN
cord-259237-aty0vrat	37	9	by	by	IN
cord-259237-aty0vrat	37	10	a	a	DT
cord-259237-aty0vrat	37	11	series	series	NN
cord-259237-aty0vrat	37	12	of	of	IN
cord-259237-aty0vrat	37	13	enzymes	enzyme	NNS
cord-259237-aty0vrat	37	14	in	in	IN
cord-259237-aty0vrat	37	15	both	both	CC
cord-259237-aty0vrat	37	16	the	the	DT
cord-259237-aty0vrat	37	17	ER	ER	NNP
cord-259237-aty0vrat	37	18	and	and	CC
cord-259237-aty0vrat	37	19	the	the	DT
cord-259237-aty0vrat	37	20	Golgi	Golgi	NNP
cord-259237-aty0vrat	37	21	apparatus	apparatus	NN
cord-259237-aty0vrat	37	22	to	to	TO
cord-259237-aty0vrat	37	23	remold	remold	VB
cord-259237-aty0vrat	37	24	the	the	DT
cord-259237-aty0vrat	37	25	core	core	NN
cord-259237-aty0vrat	37	26	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	37	27	into	into	IN
cord-259237-aty0vrat	37	28	diverse	diverse	JJ
cord-259237-aty0vrat	37	29	N	n	CD
cord-259237-aty0vrat	37	30	-	-	HYPH
cord-259237-aty0vrat	37	31	linked	link	VBN
cord-259237-aty0vrat	37	32	glycan	glycan	NN
cord-259237-aty0vrat	37	33	structures	structure	NNS
cord-259237-aty0vrat	37	34	(	(	-LRB-
cord-259237-aty0vrat	37	35	Figure	figure	NN
cord-259237-aty0vrat	37	36	1B	1b	CD
cord-259237-aty0vrat	37	37	)	)	-RRB-
cord-259237-aty0vrat	37	38	.	.	.
cord-259237-aty0vrat	38	1	The	the	DT
cord-259237-aty0vrat	38	2	first	first	JJ
cord-259237-aty0vrat	38	3	step	step	NN
cord-259237-aty0vrat	38	4	in	in	IN
cord-259237-aty0vrat	38	5	this	this	DT
cord-259237-aty0vrat	38	6	process	process	NN
cord-259237-aty0vrat	38	7	is	be	VBZ
cord-259237-aty0vrat	38	8	the	the	DT
cord-259237-aty0vrat	38	9	sequential	sequential	JJ
cord-259237-aty0vrat	38	10	removal	removal	NN
cord-259237-aty0vrat	38	11	of	of	IN
cord-259237-aty0vrat	38	12	the	the	DT
cord-259237-aty0vrat	38	13	two	two	CD
cord-259237-aty0vrat	38	14	outermost	outermost	JJ
cord-259237-aty0vrat	38	15	Glc	Glc	NNP
cord-259237-aty0vrat	38	16	residues	residue	NNS
cord-259237-aty0vrat	38	17	on	on	IN
cord-259237-aty0vrat	38	18	branch	branch	NN
cord-259237-aty0vrat	38	19	A.	a.	NN
cord-259237-aty0vrat	39	1	The	the	DT
cord-259237-aty0vrat	39	2	first	first	JJ
cord-259237-aty0vrat	39	3	Glc	Glc	NNP
cord-259237-aty0vrat	39	4	residue	residue	NN
cord-259237-aty0vrat	39	5	is	be	VBZ
cord-259237-aty0vrat	39	6	removed	remove	VBN
cord-259237-aty0vrat	39	7	by	by	IN
cord-259237-aty0vrat	39	8	glucosidase	glucosidase	NNP
cord-259237-aty0vrat	39	9	I	I	NNP
cord-259237-aty0vrat	39	10	(	(	-LRB-
cord-259237-aty0vrat	39	11	GI	GI	NNP
cord-259237-aty0vrat	39	12	)	)	-RRB-
cord-259237-aty0vrat	39	13	,	,	,
cord-259237-aty0vrat	39	14	resulting	result	VBG
cord-259237-aty0vrat	39	15	in	in	IN
cord-259237-aty0vrat	39	16	the	the	DT
cord-259237-aty0vrat	39	17	di	di	NN
cord-259237-aty0vrat	39	18	-	-	HYPH
cord-259237-aty0vrat	39	19	glycosylated	glycosylate	VBN
cord-259237-aty0vrat	39	20	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	40	1	Glc	Glc	NNP
cord-259237-aty0vrat	40	2	2	2	CD
cord-259237-aty0vrat	40	3	Man	Man	NNP
cord-259237-aty0vrat	40	4	9	9	CD
cord-259237-aty0vrat	40	5	GlcNAc	glcnac	NN
cord-259237-aty0vrat	40	6	2	2	CD
cord-259237-aty0vrat	40	7	,	,	,
cord-259237-aty0vrat	40	8	which	which	WDT
cord-259237-aty0vrat	40	9	is	be	VBZ
cord-259237-aty0vrat	40	10	recognized	recognize	VBN
cord-259237-aty0vrat	40	11	by	by	IN
cord-259237-aty0vrat	40	12	an	an	DT
cord-259237-aty0vrat	40	13	ER	ER	NNP
cord-259237-aty0vrat	40	14	transmembrane	transmembrane	NN
cord-259237-aty0vrat	40	15	lectin	lectin	NN
cord-259237-aty0vrat	40	16	malectin	malectin	NN
cord-259237-aty0vrat	40	17	[	[	-LRB-
cord-259237-aty0vrat	40	18	21	21	CD
cord-259237-aty0vrat	40	19	]	]	-RRB-
cord-259237-aty0vrat	40	20	.	.	.
cord-259237-aty0vrat	41	1	The	the	DT
cord-259237-aty0vrat	41	2	second	second	JJ
cord-259237-aty0vrat	41	3	Glc	Glc	NNP
cord-259237-aty0vrat	41	4	residue	residue	NN
cord-259237-aty0vrat	41	5	is	be	VBZ
cord-259237-aty0vrat	41	6	then	then	RB
cord-259237-aty0vrat	41	7	removed	remove	VBN
cord-259237-aty0vrat	41	8	by	by	IN
cord-259237-aty0vrat	41	9	glucosidase	glucosidase	NNP
cord-259237-aty0vrat	41	10	II	II	NNP
cord-259237-aty0vrat	41	11	(	(	-LRB-
cord-259237-aty0vrat	41	12	GII	GII	NNP
cord-259237-aty0vrat	41	13	)	)	-RRB-
cord-259237-aty0vrat	41	14	,	,	,
cord-259237-aty0vrat	41	15	resulting	result	VBG
cord-259237-aty0vrat	41	16	in	in	IN
cord-259237-aty0vrat	41	17	the	the	DT
cord-259237-aty0vrat	41	18	mono	mono	NN
cord-259237-aty0vrat	41	19	-	-	HYPH
cord-259237-aty0vrat	41	20	glucosylated	glucosylated	JJ
cord-259237-aty0vrat	41	21	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	41	22	Glc	Glc	NNP
cord-259237-aty0vrat	41	23	1	1	CD
cord-259237-aty0vrat	41	24	Man	Man	NNP
cord-259237-aty0vrat	41	25	9	9	CD
cord-259237-aty0vrat	41	26	GlcNAc	glcnac	NN
cord-259237-aty0vrat	41	27	2	2	CD
cord-259237-aty0vrat	41	28	,	,	,
cord-259237-aty0vrat	41	29	which	which	WDT
cord-259237-aty0vrat	41	30	is	be	VBZ
cord-259237-aty0vrat	41	31	recognized	recognize	VBN
cord-259237-aty0vrat	41	32	by	by	IN
cord-259237-aty0vrat	41	33	two	two	CD
cord-259237-aty0vrat	41	34	other	other	JJ
cord-259237-aty0vrat	41	35	ER	ER	NNP
cord-259237-aty0vrat	41	36	lectins	lectin	NNS
cord-259237-aty0vrat	41	37	,	,	,
cord-259237-aty0vrat	41	38	the	the	DT
cord-259237-aty0vrat	41	39	membrane	membrane	NN
cord-259237-aty0vrat	41	40	-	-	HYPH
cord-259237-aty0vrat	41	41	bound	bind	VBN
cord-259237-aty0vrat	41	42	calnexin	calnexin	NN
cord-259237-aty0vrat	41	43	(	(	-LRB-
cord-259237-aty0vrat	41	44	CNX	CNX	NNP
cord-259237-aty0vrat	41	45	)	)	-RRB-
cord-259237-aty0vrat	42	1	and/or	and/or	CC
cord-259237-aty0vrat	42	2	soluble	soluble	JJ
cord-259237-aty0vrat	42	3	calreticulin	calreticulin	NNP
cord-259237-aty0vrat	42	4	(	(	-LRB-
cord-259237-aty0vrat	42	5	CRT	CRT	NNP
cord-259237-aty0vrat	42	6	)	)	-RRB-
cord-259237-aty0vrat	42	7	.	.	.
cord-259237-aty0vrat	43	1	Interaction	interaction	NN
cord-259237-aty0vrat	43	2	with	with	IN
cord-259237-aty0vrat	43	3	these	these	DT
cord-259237-aty0vrat	43	4	two	two	CD
cord-259237-aty0vrat	43	5	chaperones	chaperone	NNS
cord-259237-aty0vrat	43	6	segregates	segregate	VBZ
cord-259237-aty0vrat	43	7	the	the	DT
cord-259237-aty0vrat	43	8	newly	newly	RB
cord-259237-aty0vrat	43	9	formed	form	VBN
cord-259237-aty0vrat	43	10	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	43	11	and	and	CC
cord-259237-aty0vrat	43	12	provides	provide	VBZ
cord-259237-aty0vrat	43	13	access	access	NN
cord-259237-aty0vrat	43	14	to	to	IN
cord-259237-aty0vrat	43	15	protein	protein	NN
cord-259237-aty0vrat	43	16	disulfide	disulfide	NN
cord-259237-aty0vrat	43	17	isomerases	isomerase	NNS
cord-259237-aty0vrat	43	18	(	(	-LRB-
cord-259237-aty0vrat	43	19	PDIs	pdi	NNS
cord-259237-aty0vrat	43	20	)	)	-RRB-
cord-259237-aty0vrat	43	21	such	such	JJ
cord-259237-aty0vrat	43	22	as	as	IN
cord-259237-aty0vrat	43	23	ERp57	ERp57	NNS
cord-259237-aty0vrat	43	24	,	,	,
cord-259237-aty0vrat	43	25	which	which	WDT
cord-259237-aty0vrat	43	26	promotes	promote	VBZ
cord-259237-aty0vrat	43	27	disulfide	disulfide	JJ
cord-259237-aty0vrat	43	28	bond	bond	NN
cord-259237-aty0vrat	43	29	formation	formation	NN
cord-259237-aty0vrat	43	30	,	,	,
cord-259237-aty0vrat	43	31	resulting	result	VBG
cord-259237-aty0vrat	43	32	in	in	IN
cord-259237-aty0vrat	43	33	protein	protein	NN
cord-259237-aty0vrat	43	34	folding	fold	VBG
cord-259237-aty0vrat	43	35	into	into	IN
cord-259237-aty0vrat	43	36	a	a	DT
cord-259237-aty0vrat	43	37	native	native	JJ
cord-259237-aty0vrat	43	38	conformation	conformation	NN
cord-259237-aty0vrat	43	39	.	.	.
cord-259237-aty0vrat	44	1	Once	once	RB
cord-259237-aty0vrat	44	2	a	a	DT
cord-259237-aty0vrat	44	3	protein	protein	NN
cord-259237-aty0vrat	44	4	is	be	VBZ
cord-259237-aty0vrat	44	5	properly	properly	RB
cord-259237-aty0vrat	44	6	folded	fold	VBN
cord-259237-aty0vrat	44	7	,	,	,
cord-259237-aty0vrat	44	8	GII	GII	NNP
cord-259237-aty0vrat	44	9	cleaves	cleave	VBZ
cord-259237-aty0vrat	44	10	the	the	DT
cord-259237-aty0vrat	44	11	last	last	JJ
cord-259237-aty0vrat	44	12	Glc	Glc	NNP
cord-259237-aty0vrat	44	13	residue	residue	NN
cord-259237-aty0vrat	44	14	on	on	IN
cord-259237-aty0vrat	44	15	branch	branch	NN
cord-259237-aty0vrat	44	16	A	A	NNP
cord-259237-aty0vrat	44	17	,	,	,
cord-259237-aty0vrat	44	18	which	which	WDT
cord-259237-aty0vrat	44	19	releases	release	VBZ
cord-259237-aty0vrat	44	20	the	the	DT
cord-259237-aty0vrat	44	21	protein	protein	NN
cord-259237-aty0vrat	44	22	from	from	IN
cord-259237-aty0vrat	44	23	the	the	DT
cord-259237-aty0vrat	44	24	CNX	CNX	NNP
cord-259237-aty0vrat	44	25	/	/	SYM
cord-259237-aty0vrat	44	26	CRT	CRT	NNP
cord-259237-aty0vrat	44	27	cycle	cycle	NN
cord-259237-aty0vrat	44	28	.	.	.
cord-259237-aty0vrat	45	1	The	the	DT
cord-259237-aty0vrat	45	2	ER	ER	NNP
cord-259237-aty0vrat	45	3	class	class	NN
cord-259237-aty0vrat	45	4	I	i	NN
cord-259237-aty0vrat	45	5	α	α	NN
cord-259237-aty0vrat	45	6	-	-	HYPH
cord-259237-aty0vrat	45	7	mannosidase	mannosidase	NN
cord-259237-aty0vrat	45	8	(	(	-LRB-
cord-259237-aty0vrat	45	9	ERManI	ERManI	NNP
cord-259237-aty0vrat	45	10	)	)	-RRB-
cord-259237-aty0vrat	45	11	then	then	RB
cord-259237-aty0vrat	45	12	cleaves	cleave	VBZ
cord-259237-aty0vrat	45	13	the	the	DT
cord-259237-aty0vrat	45	14	outermost	outermost	JJ
cord-259237-aty0vrat	45	15	Man	man	NN
cord-259237-aty0vrat	45	16	residue	residue	NN
cord-259237-aty0vrat	45	17	on	on	IN
cord-259237-aty0vrat	45	18	branch	branch	NN
cord-259237-aty0vrat	45	19	b	b	NN
cord-259237-aty0vrat	45	20	on	on	IN
cord-259237-aty0vrat	45	21	native	native	JJ
cord-259237-aty0vrat	45	22	proteins	protein	NNS
cord-259237-aty0vrat	45	23	,	,	,
cord-259237-aty0vrat	45	24	resulting	result	VBG
cord-259237-aty0vrat	45	25	in	in	IN
cord-259237-aty0vrat	45	26	the	the	DT
cord-259237-aty0vrat	45	27	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	45	28	Man	Man	NNP
cord-259237-aty0vrat	45	29	8	8	CD
cord-259237-aty0vrat	45	30	GlcNAc	GlcNAc	NNP
cord-259237-aty0vrat	45	31	2	2	CD
cord-259237-aty0vrat	45	32	.	.	.
cord-259237-aty0vrat	46	1	These	these	DT
cord-259237-aty0vrat	46	2	high	high	JJ
cord-259237-aty0vrat	46	3	-	-	HYPH
cord-259237-aty0vrat	46	4	Man	man	NN
cord-259237-aty0vrat	46	5	glycans	glycan	NNS
cord-259237-aty0vrat	46	6	are	be	VBP
cord-259237-aty0vrat	46	7	then	then	RB
cord-259237-aty0vrat	46	8	recognized	recognize	VBN
cord-259237-aty0vrat	46	9	by	by	IN
cord-259237-aty0vrat	46	10	lectins	lectin	NNS
cord-259237-aty0vrat	46	11	including	include	VBG
cord-259237-aty0vrat	46	12	ER	ER	NNP
cord-259237-aty0vrat	46	13	-	-	HYPH
cord-259237-aty0vrat	46	14	Golgi	Golgi	NNP
cord-259237-aty0vrat	46	15	intermediate	intermediate	JJ
cord-259237-aty0vrat	46	16	compartment-53	compartment-53	NNP
cord-259237-aty0vrat	46	17	(	(	-LRB-
cord-259237-aty0vrat	46	18	ERGIC-53	ERGIC-53	NNP
cord-259237-aty0vrat	46	19	)	)	-RRB-
cord-259237-aty0vrat	46	20	,	,	,
cord-259237-aty0vrat	46	21	vesicular	vesicular	JJ
cord-259237-aty0vrat	46	22	integral	integral	JJ
cord-259237-aty0vrat	46	23	membrane	membrane	NN
cord-259237-aty0vrat	46	24	protein	protein	NN
cord-259237-aty0vrat	46	25	of	of	IN
cord-259237-aty0vrat	46	26	36Kda	36kda	CD
cord-259237-aty0vrat	46	27	(	(	-LRB-
cord-259237-aty0vrat	46	28	VIP36	VIP36	NNP
cord-259237-aty0vrat	46	29	)	)	-RRB-
cord-259237-aty0vrat	46	30	,	,	,
cord-259237-aty0vrat	46	31	and	and	CC
cord-259237-aty0vrat	46	32	VIP36-like	vip36-like	UH
cord-259237-aty0vrat	46	33	(	(	-LRB-
cord-259237-aty0vrat	46	34	VIPL	VIPL	NNP
cord-259237-aty0vrat	46	35	)	)	-RRB-
cord-259237-aty0vrat	46	36	,	,	,
cord-259237-aty0vrat	46	37	which	which	WDT
cord-259237-aty0vrat	46	38	promote	promote	VBP
cord-259237-aty0vrat	46	39	trafficking	trafficking	NN
cord-259237-aty0vrat	46	40	from	from	IN
cord-259237-aty0vrat	46	41	the	the	DT
cord-259237-aty0vrat	46	42	ER	ER	NNP
cord-259237-aty0vrat	46	43	to	to	IN
cord-259237-aty0vrat	46	44	the	the	DT
cord-259237-aty0vrat	46	45	Golgi	Golgi	NNP
cord-259237-aty0vrat	46	46	[	[	-LRB-
cord-259237-aty0vrat	46	47	22	22	CD
cord-259237-aty0vrat	46	48	]	]	-RRB-
cord-259237-aty0vrat	46	49	.	.	.
cord-259237-aty0vrat	47	1	The	the	DT
cord-259237-aty0vrat	47	2	remaining	remain	VBG
cord-259237-aty0vrat	47	3	Man	man	NN
cord-259237-aty0vrat	47	4	residues	residue	NNS
cord-259237-aty0vrat	47	5	are	be	VBP
cord-259237-aty0vrat	47	6	cleaved	cleave	VBN
cord-259237-aty0vrat	47	7	by	by	IN
cord-259237-aty0vrat	47	8	the	the	DT
cord-259237-aty0vrat	47	9	Golgi	Golgi	NNP
cord-259237-aty0vrat	47	10	mannosidases	mannosidase	NNS
cord-259237-aty0vrat	47	11	,	,	,
cord-259237-aty0vrat	47	12	and	and	CC
cord-259237-aty0vrat	47	13	the	the	DT
cord-259237-aty0vrat	47	14	glycan	glycan	NN
cord-259237-aty0vrat	47	15	remolding	remolding	NN
cord-259237-aty0vrat	47	16	process	process	NN
cord-259237-aty0vrat	47	17	is	be	VBZ
cord-259237-aty0vrat	47	18	continued	continue	VBN
cord-259237-aty0vrat	47	19	through	through	IN
cord-259237-aty0vrat	47	20	the	the	DT
cord-259237-aty0vrat	47	21	remainder	remainder	NN
cord-259237-aty0vrat	47	22	of	of	IN
cord-259237-aty0vrat	47	23	the	the	DT
cord-259237-aty0vrat	47	24	N	n	CD
cord-259237-aty0vrat	47	25	-	-	HYPH
cord-259237-aty0vrat	47	26	glycosylation	glycosylation	NN
cord-259237-aty0vrat	47	27	pathway	pathway	NN
cord-259237-aty0vrat	47	28	,	,	,
cord-259237-aty0vrat	47	29	which	which	WDT
cord-259237-aty0vrat	47	30	generates	generate	VBZ
cord-259237-aty0vrat	47	31	functional	functional	JJ
cord-259237-aty0vrat	47	32	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	47	33	that	that	WDT
cord-259237-aty0vrat	47	34	are	be	VBP
cord-259237-aty0vrat	47	35	delivered	deliver	VBN
cord-259237-aty0vrat	47	36	to	to	IN
cord-259237-aty0vrat	47	37	the	the	DT
cord-259237-aty0vrat	47	38	cell	cell	NN
cord-259237-aty0vrat	47	39	surface	surface	NN
cord-259237-aty0vrat	47	40	(	(	-LRB-
cord-259237-aty0vrat	47	41	Figure	figure	NN
cord-259237-aty0vrat	47	42	1B	1b	CD
cord-259237-aty0vrat	47	43	)	)	-RRB-
cord-259237-aty0vrat	47	44	.	.	.
cord-259237-aty0vrat	48	1	In	in	IN
cord-259237-aty0vrat	48	2	addition	addition	NN
cord-259237-aty0vrat	48	3	to	to	IN
cord-259237-aty0vrat	48	4	these	these	DT
cord-259237-aty0vrat	48	5	chaperones	chaperone	NNS
cord-259237-aty0vrat	48	6	and	and	CC
cord-259237-aty0vrat	48	7	enzymes	enzyme	NNS
cord-259237-aty0vrat	48	8	that	that	WDT
cord-259237-aty0vrat	48	9	promote	promote	VBP
cord-259237-aty0vrat	48	10	protein	protein	NN
cord-259237-aty0vrat	48	11	folding	folding	NN
cord-259237-aty0vrat	48	12	,	,	,
cord-259237-aty0vrat	48	13	the	the	DT
cord-259237-aty0vrat	48	14	ER	ER	NNP
cord-259237-aty0vrat	48	15	is	be	VBZ
cord-259237-aty0vrat	48	16	also	also	RB
cord-259237-aty0vrat	48	17	equipped	equip	VBN
cord-259237-aty0vrat	48	18	with	with	IN
cord-259237-aty0vrat	48	19	a	a	DT
cord-259237-aty0vrat	48	20	unique	unique	JJ
cord-259237-aty0vrat	48	21	quality	quality	NN
cord-259237-aty0vrat	48	22	control	control	NN
cord-259237-aty0vrat	48	23	mechanism	mechanism	NN
cord-259237-aty0vrat	48	24	that	that	WDT
cord-259237-aty0vrat	48	25	extracts	extract	VBZ
cord-259237-aty0vrat	48	26	and	and	CC
cord-259237-aty0vrat	48	27	degrades	degrade	VBZ
cord-259237-aty0vrat	48	28	proteins	protein	NNS
cord-259237-aty0vrat	48	29	that	that	WDT
cord-259237-aty0vrat	48	30	are	be	VBP
cord-259237-aty0vrat	48	31	not	not	RB
cord-259237-aty0vrat	48	32	correctly	correctly	RB
cord-259237-aty0vrat	48	33	folded	fold	VBN
cord-259237-aty0vrat	48	34	or	or	CC
cord-259237-aty0vrat	48	35	assembled	assemble	VBN
cord-259237-aty0vrat	48	36	into	into	IN
cord-259237-aty0vrat	48	37	their	-PRON-	PRP$
cord-259237-aty0vrat	48	38	native	native	JJ
cord-259237-aty0vrat	48	39	conformation	conformation	NN
cord-259237-aty0vrat	48	40	,	,	,
cord-259237-aty0vrat	48	41	which	which	WDT
cord-259237-aty0vrat	48	42	is	be	VBZ
cord-259237-aty0vrat	48	43	called	call	VBN
cord-259237-aty0vrat	48	44	ER	ER	NNP
cord-259237-aty0vrat	48	45	-	-	HYPH
cord-259237-aty0vrat	48	46	associated	associate	VBN
cord-259237-aty0vrat	48	47	protein	protein	NN
cord-259237-aty0vrat	48	48	degradation	degradation	NN
cord-259237-aty0vrat	48	49	(	(	-LRB-
cord-259237-aty0vrat	48	50	ERAD	ERAD	NNP
cord-259237-aty0vrat	48	51	)	)	-RRB-
cord-259237-aty0vrat	49	1	[	[	-LRB-
cord-259237-aty0vrat	49	2	23	23	CD
cord-259237-aty0vrat	49	3	]	]	-RRB-
cord-259237-aty0vrat	49	4	.	.	.
cord-259237-aty0vrat	50	1	In	in	IN
cord-259237-aty0vrat	50	2	fact	fact	NN
cord-259237-aty0vrat	50	3	,	,	,
cord-259237-aty0vrat	50	4	the	the	DT
cord-259237-aty0vrat	50	5	folding	folding	NN
cord-259237-aty0vrat	50	6	efficiency	efficiency	NN
cord-259237-aty0vrat	50	7	of	of	IN
cord-259237-aty0vrat	50	8	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	50	9	in	in	IN
cord-259237-aty0vrat	50	10	the	the	DT
cord-259237-aty0vrat	50	11	ER	ER	NNP
cord-259237-aty0vrat	50	12	is	be	VBZ
cord-259237-aty0vrat	50	13	very	very	RB
cord-259237-aty0vrat	50	14	low	low	JJ
cord-259237-aty0vrat	50	15	,	,	,
cord-259237-aty0vrat	50	16	which	which	WDT
cord-259237-aty0vrat	50	17	requires	require	VBZ
cord-259237-aty0vrat	50	18	cycles	cycle	NNS
cord-259237-aty0vrat	50	19	of	of	IN
cord-259237-aty0vrat	50	20	association	association	NN
cord-259237-aty0vrat	50	21	and	and	CC
cord-259237-aty0vrat	50	22	dissociation	dissociation	NN
cord-259237-aty0vrat	50	23	from	from	IN
cord-259237-aty0vrat	50	24	CNX	CNX	NNP
cord-259237-aty0vrat	50	25	/	/	SYM
cord-259237-aty0vrat	50	26	CRT	CRT	NNP
cord-259237-aty0vrat	50	27	to	to	TO
cord-259237-aty0vrat	50	28	ensure	ensure	VB
cord-259237-aty0vrat	50	29	proper	proper	JJ
cord-259237-aty0vrat	50	30	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	50	31	maturation	maturation	NN
cord-259237-aty0vrat	50	32	.	.	.
cord-259237-aty0vrat	51	1	If	if	IN
cord-259237-aty0vrat	51	2	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	51	3	with	with	IN
cord-259237-aty0vrat	51	4	the	the	DT
cord-259237-aty0vrat	51	5	Man	Man	NNP
cord-259237-aty0vrat	51	6	9	9	CD
cord-259237-aty0vrat	51	7	GlcNAc	glcnac	NN
cord-259237-aty0vrat	51	8	2	2	CD
cord-259237-aty0vrat	51	9	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	51	10	display	display	NN
cord-259237-aty0vrat	51	11	non	non	JJ
cord-259237-aty0vrat	51	12	-	-	JJ
cord-259237-aty0vrat	51	13	native	native	JJ
cord-259237-aty0vrat	51	14	conformations	conformation	NNS
cord-259237-aty0vrat	51	15	,	,	,
cord-259237-aty0vrat	51	16	they	-PRON-	PRP
cord-259237-aty0vrat	51	17	are	be	VBP
cord-259237-aty0vrat	51	18	reglucosylated	reglucosylate	VBN
cord-259237-aty0vrat	51	19	by	by	IN
cord-259237-aty0vrat	51	20	the	the	DT
cord-259237-aty0vrat	51	21	UDP	UDP	NNP
cord-259237-aty0vrat	51	22	-	-	HYPH
cord-259237-aty0vrat	51	23	Glc	Glc	NNP
cord-259237-aty0vrat	51	24	:	:	:
cord-259237-aty0vrat	51	25	unfolded	unfold	VBN
cord-259237-aty0vrat	51	26	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	51	27	glucosyltransferase	glucosyltransferase	NN
cord-259237-aty0vrat	51	28	(	(	-LRB-
cord-259237-aty0vrat	51	29	UGT1	UGT1	NNP
cord-259237-aty0vrat	51	30	or	or	CC
cord-259237-aty0vrat	51	31	UGGT	UGGT	NNP
cord-259237-aty0vrat	51	32	)	)	-RRB-
cord-259237-aty0vrat	51	33	,	,	,
cord-259237-aty0vrat	51	34	and	and	CC
cord-259237-aty0vrat	51	35	are	be	VBP
cord-259237-aty0vrat	51	36	subject	subject	JJ
cord-259237-aty0vrat	51	37	to	to	IN
cord-259237-aty0vrat	51	38	additional	additional	JJ
cord-259237-aty0vrat	51	39	rounds	round	NNS
cord-259237-aty0vrat	51	40	of	of	IN
cord-259237-aty0vrat	51	41	re	re	NN
cord-259237-aty0vrat	51	42	-	-	NN
cord-259237-aty0vrat	51	43	engagement	engagement	NN
cord-259237-aty0vrat	51	44	with	with	IN
cord-259237-aty0vrat	51	45	the	the	DT
cord-259237-aty0vrat	51	46	CNX	CNX	NNP
cord-259237-aty0vrat	51	47	/	/	SYM
cord-259237-aty0vrat	51	48	CRT	CRT	NNP
cord-259237-aty0vrat	51	49	machinery	machinery	NN
cord-259237-aty0vrat	51	50	until	until	IN
cord-259237-aty0vrat	51	51	folding	folding	NN
cord-259237-aty0vrat	51	52	is	be	VBZ
cord-259237-aty0vrat	51	53	achieved	achieve	VBN
cord-259237-aty0vrat	51	54	.	.	.
cord-259237-aty0vrat	52	1	However	however	RB
cord-259237-aty0vrat	52	2	,	,	,
cord-259237-aty0vrat	52	3	if	if	IN
cord-259237-aty0vrat	52	4	a	a	DT
cord-259237-aty0vrat	52	5	certain	certain	JJ
cord-259237-aty0vrat	52	6	time	time	NN
cord-259237-aty0vrat	52	7	frame	frame	NN
cord-259237-aty0vrat	52	8	for	for	IN
cord-259237-aty0vrat	52	9	the	the	DT
cord-259237-aty0vrat	52	10	folding	folding	NN
cord-259237-aty0vrat	52	11	is	be	VBZ
cord-259237-aty0vrat	52	12	exceeded	exceed	VBN
cord-259237-aty0vrat	52	13	,	,	,
cord-259237-aty0vrat	52	14	proteins	protein	NNS
cord-259237-aty0vrat	52	15	may	may	MD
cord-259237-aty0vrat	52	16	never	never	RB
cord-259237-aty0vrat	52	17	fold	fold	VB
cord-259237-aty0vrat	52	18	properly	properly	RB
cord-259237-aty0vrat	52	19	.	.	.
cord-259237-aty0vrat	53	1	Misfolded	Misfolded	NNP
cord-259237-aty0vrat	53	2	proteins	protein	NNS
cord-259237-aty0vrat	53	3	are	be	VBP
cord-259237-aty0vrat	53	4	sequestered	sequester	VBN
cord-259237-aty0vrat	53	5	into	into	IN
cord-259237-aty0vrat	53	6	coat	coat	NN
cord-259237-aty0vrat	53	7	protein	protein	NN
cord-259237-aty0vrat	53	8	complex	complex	NN
cord-259237-aty0vrat	53	9	II	II	NNP
cord-259237-aty0vrat	53	10	(	(	-LRB-
cord-259237-aty0vrat	53	11	COP	COP	NNP
cord-259237-aty0vrat	53	12	-	-	HYPH
cord-259237-aty0vrat	53	13	II	II	NNP
cord-259237-aty0vrat	53	14	)	)	-RRB-
cord-259237-aty0vrat	53	15	-dependent	-dependent	VBD
cord-259237-aty0vrat	53	16	,	,	,
cord-259237-aty0vrat	53	17	highly	highly	RB
cord-259237-aty0vrat	53	18	mobile	mobile	JJ
cord-259237-aty0vrat	53	19	ER	er	NN
cord-259237-aty0vrat	53	20	-	-	HYPH
cord-259237-aty0vrat	53	21	derived	derive	VBN
cord-259237-aty0vrat	53	22	quality	quality	NN
cord-259237-aty0vrat	53	23	control	control	NN
cord-259237-aty0vrat	53	24	vesicles	vesicle	NNS
cord-259237-aty0vrat	53	25	(	(	-LRB-
cord-259237-aty0vrat	53	26	QCVs	QCVs	NNP
cord-259237-aty0vrat	53	27	)	)	-RRB-
cord-259237-aty0vrat	53	28	,	,	,
cord-259237-aty0vrat	53	29	where	where	WRB
cord-259237-aty0vrat	53	30	ERManI	ERManI	NNP
cord-259237-aty0vrat	53	31	is	be	VBZ
cord-259237-aty0vrat	53	32	enriched	enrich	VBN
cord-259237-aty0vrat	53	33	(	(	-LRB-
cord-259237-aty0vrat	53	34	Figure	figure	NN
cord-259237-aty0vrat	53	35	1B	1b	CD
cord-259237-aty0vrat	53	36	)	)	-RRB-
cord-259237-aty0vrat	53	37	[	[	-LRB-
cord-259237-aty0vrat	53	38	24	24	CD
cord-259237-aty0vrat	53	39	]	]	-RRB-
cord-259237-aty0vrat	53	40	.	.	.
cord-259237-aty0vrat	54	1	Because	because	IN
cord-259237-aty0vrat	54	2	ERManI	ERManI	NNP
cord-259237-aty0vrat	54	3	is	be	VBZ
cord-259237-aty0vrat	54	4	able	able	JJ
cord-259237-aty0vrat	54	5	to	to	TO
cord-259237-aty0vrat	54	6	excise	excise	VB
cord-259237-aty0vrat	54	7	all	all	DT
cord-259237-aty0vrat	54	8	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	54	9	residues	residue	NNS
cord-259237-aty0vrat	54	10	when	when	WRB
cord-259237-aty0vrat	54	11	it	-PRON-	PRP
cord-259237-aty0vrat	54	12	is	be	VBZ
cord-259237-aty0vrat	54	13	expressed	express	VBN
cord-259237-aty0vrat	54	14	at	at	IN
cord-259237-aty0vrat	54	15	much	much	RB
cord-259237-aty0vrat	54	16	higher	high	JJR
cord-259237-aty0vrat	54	17	levels	level	NNS
cord-259237-aty0vrat	54	18	in	in	IN
cord-259237-aty0vrat	54	19	vitro	vitro	FW
cord-259237-aty0vrat	54	20	[	[	-LRB-
cord-259237-aty0vrat	54	21	25	25	CD
cord-259237-aty0vrat	54	22	]	]	-RRB-
cord-259237-aty0vrat	54	23	,	,	,
cord-259237-aty0vrat	54	24	the	the	DT
cord-259237-aty0vrat	54	25	enzyme	enzyme	NN
cord-259237-aty0vrat	54	26	may	may	MD
cord-259237-aty0vrat	54	27	catalyze	catalyze	VB
cord-259237-aty0vrat	54	28	extensive	extensive	JJ
cord-259237-aty0vrat	54	29	demannosylation	demannosylation	NN
cord-259237-aty0vrat	54	30	,	,	,
cord-259237-aty0vrat	54	31	resulting	result	VBG
cord-259237-aty0vrat	54	32	in	in	IN
cord-259237-aty0vrat	54	33	the	the	DT
cord-259237-aty0vrat	54	34	production	production	NN
cord-259237-aty0vrat	54	35	of	of	IN
cord-259237-aty0vrat	54	36	low	low	JJ
cord-259237-aty0vrat	54	37	-	-	HYPH
cord-259237-aty0vrat	54	38	Man	man	NN
cord-259237-aty0vrat	54	39	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	54	40	Man	man	NN
cord-259237-aty0vrat	54	41	5	5	CD
cord-259237-aty0vrat	54	42	GlcNAc	glcnac	NN
cord-259237-aty0vrat	54	43	2	2	CD
cord-259237-aty0vrat	54	44	-containing	-containe	VBG
cord-259237-aty0vrat	54	45	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	54	46	precursors	precursor	NNS
cord-259237-aty0vrat	54	47	.	.	.
cord-259237-aty0vrat	55	1	The	the	DT
cord-259237-aty0vrat	55	2	removal	removal	NN
cord-259237-aty0vrat	55	3	of	of	IN
cord-259237-aty0vrat	55	4	the	the	DT
cord-259237-aty0vrat	55	5	a	a	DT
cord-259237-aty0vrat	55	6	branch	branch	NN
cord-259237-aty0vrat	55	7	terminal	terminal	NN
cord-259237-aty0vrat	55	8	Man	man	NN
cord-259237-aty0vrat	55	9	residue	residue	NN
cord-259237-aty0vrat	55	10	,	,	,
cord-259237-aty0vrat	55	11	which	which	WDT
cord-259237-aty0vrat	55	12	is	be	VBZ
cord-259237-aty0vrat	55	13	the	the	DT
cord-259237-aty0vrat	55	14	acceptor	acceptor	NN
cord-259237-aty0vrat	55	15	for	for	IN
cord-259237-aty0vrat	55	16	Glc	Glc	NNP
cord-259237-aty0vrat	55	17	transferred	transfer	VBN
cord-259237-aty0vrat	55	18	by	by	IN
cord-259237-aty0vrat	55	19	UGGT	UGGT	NNP
cord-259237-aty0vrat	55	20	,	,	,
cord-259237-aty0vrat	55	21	disables	disable	VBZ
cord-259237-aty0vrat	55	22	these	these	DT
cord-259237-aty0vrat	55	23	proteins	protein	NNS
cord-259237-aty0vrat	55	24	from	from	IN
cord-259237-aty0vrat	55	25	reengagement	reengagement	NN
cord-259237-aty0vrat	55	26	with	with	IN
cord-259237-aty0vrat	55	27	CNX	CNX	NNP
cord-259237-aty0vrat	55	28	/	/	SYM
cord-259237-aty0vrat	55	29	CRT	CRT	NNP
cord-259237-aty0vrat	55	30	and	and	CC
cord-259237-aty0vrat	55	31	re	re	NN
cord-259237-aty0vrat	55	32	-	-	NN
cord-259237-aty0vrat	55	33	entering	enter	VBG
cord-259237-aty0vrat	55	34	into	into	IN
cord-259237-aty0vrat	55	35	the	the	DT
cord-259237-aty0vrat	55	36	folding	folding	NN
cord-259237-aty0vrat	55	37	cycle	cycle	NN
cord-259237-aty0vrat	55	38	.	.	.
cord-259237-aty0vrat	56	1	Importantly	importantly	RB
cord-259237-aty0vrat	56	2	,	,	,
cord-259237-aty0vrat	56	3	the	the	DT
cord-259237-aty0vrat	56	4	low	low	JJ
cord-259237-aty0vrat	56	5	-	-	HYPH
cord-259237-aty0vrat	56	6	Man	man	NN
cord-259237-aty0vrat	56	7	N	n	NN
cord-259237-aty0vrat	56	8	-	-	HYPH
cord-259237-aty0vrat	56	9	glycans	glycan	NNS
cord-259237-aty0vrat	56	10	represent	represent	VBP
cord-259237-aty0vrat	56	11	a	a	DT
cord-259237-aty0vrat	56	12	tag	tag	NN
cord-259237-aty0vrat	56	13	for	for	IN
cord-259237-aty0vrat	56	14	defective	defective	JJ
cord-259237-aty0vrat	56	15	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	56	16	,	,	,
cord-259237-aty0vrat	56	17	targeting	target	VBG
cord-259237-aty0vrat	56	18	them	-PRON-	PRP
cord-259237-aty0vrat	56	19	to	to	IN
cord-259237-aty0vrat	56	20	ERAD	ERAD	NNP
cord-259237-aty0vrat	56	21	[	[	-LRB-
cord-259237-aty0vrat	56	22	26	26	CD
cord-259237-aty0vrat	56	23	]	]	-RRB-
cord-259237-aty0vrat	56	24	.	.	.
cord-259237-aty0vrat	57	1	Figure	figure	NN
cord-259237-aty0vrat	57	2	1B	1b	CD
cord-259237-aty0vrat	57	3	)	)	-RRB-
cord-259237-aty0vrat	58	1	[	[	-LRB-
cord-259237-aty0vrat	58	2	24	24	CD
cord-259237-aty0vrat	58	3	]	]	-RRB-
cord-259237-aty0vrat	58	4	.	.	.
cord-259237-aty0vrat	59	1	Because	because	IN
cord-259237-aty0vrat	59	2	ERManI	ERManI	NNP
cord-259237-aty0vrat	59	3	is	be	VBZ
cord-259237-aty0vrat	59	4	able	able	JJ
cord-259237-aty0vrat	59	5	to	to	TO
cord-259237-aty0vrat	59	6	excise	excise	VB
cord-259237-aty0vrat	59	7	all	all	DT
cord-259237-aty0vrat	59	8	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	59	9	residues	residue	NNS
cord-259237-aty0vrat	59	10	when	when	WRB
cord-259237-aty0vrat	59	11	it	-PRON-	PRP
cord-259237-aty0vrat	59	12	is	be	VBZ
cord-259237-aty0vrat	59	13	expressed	express	VBN
cord-259237-aty0vrat	59	14	at	at	IN
cord-259237-aty0vrat	59	15	much	much	RB
cord-259237-aty0vrat	59	16	higher	high	JJR
cord-259237-aty0vrat	59	17	levels	level	NNS
cord-259237-aty0vrat	59	18	in	in	IN
cord-259237-aty0vrat	59	19	vitro	vitro	FW
cord-259237-aty0vrat	59	20	[	[	-LRB-
cord-259237-aty0vrat	59	21	25	25	CD
cord-259237-aty0vrat	59	22	]	]	-RRB-
cord-259237-aty0vrat	59	23	,	,	,
cord-259237-aty0vrat	59	24	the	the	DT
cord-259237-aty0vrat	59	25	enzyme	enzyme	NN
cord-259237-aty0vrat	59	26	may	may	MD
cord-259237-aty0vrat	59	27	catalyze	catalyze	VB
cord-259237-aty0vrat	59	28	extensive	extensive	JJ
cord-259237-aty0vrat	59	29	demannosylation	demannosylation	NN
cord-259237-aty0vrat	59	30	,	,	,
cord-259237-aty0vrat	59	31	resulting	result	VBG
cord-259237-aty0vrat	59	32	in	in	IN
cord-259237-aty0vrat	59	33	the	the	DT
cord-259237-aty0vrat	59	34	production	production	NN
cord-259237-aty0vrat	59	35	of	of	IN
cord-259237-aty0vrat	59	36	low	low	JJ
cord-259237-aty0vrat	59	37	-	-	HYPH
cord-259237-aty0vrat	59	38	Man	man	NN
cord-259237-aty0vrat	59	39	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	59	40	Man5GlcNAc2-containing	man5glcnac2-containe	VBG
cord-259237-aty0vrat	59	41	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	59	42	precursors	precursor	NNS
cord-259237-aty0vrat	59	43	.	.	.
cord-259237-aty0vrat	60	1	The	the	DT
cord-259237-aty0vrat	60	2	removal	removal	NN
cord-259237-aty0vrat	60	3	of	of	IN
cord-259237-aty0vrat	60	4	the	the	DT
cord-259237-aty0vrat	60	5	a	a	DT
cord-259237-aty0vrat	60	6	branch	branch	NN
cord-259237-aty0vrat	60	7	terminal	terminal	NN
cord-259237-aty0vrat	60	8	Man	man	NN
cord-259237-aty0vrat	60	9	residue	residue	NN
cord-259237-aty0vrat	60	10	,	,	,
cord-259237-aty0vrat	60	11	which	which	WDT
cord-259237-aty0vrat	60	12	is	be	VBZ
cord-259237-aty0vrat	60	13	the	the	DT
cord-259237-aty0vrat	60	14	acceptor	acceptor	NN
cord-259237-aty0vrat	60	15	for	for	IN
cord-259237-aty0vrat	60	16	Glc	Glc	NNP
cord-259237-aty0vrat	60	17	transferred	transfer	VBN
cord-259237-aty0vrat	60	18	by	by	IN
cord-259237-aty0vrat	60	19	UGGT	UGGT	NNP
cord-259237-aty0vrat	60	20	,	,	,
cord-259237-aty0vrat	60	21	disables	disable	VBZ
cord-259237-aty0vrat	60	22	these	these	DT
cord-259237-aty0vrat	60	23	proteins	protein	NNS
cord-259237-aty0vrat	60	24	from	from	IN
cord-259237-aty0vrat	60	25	reengagement	reengagement	NN
cord-259237-aty0vrat	60	26	with	with	IN
cord-259237-aty0vrat	60	27	CNX	CNX	NNP
cord-259237-aty0vrat	60	28	/	/	SYM
cord-259237-aty0vrat	60	29	CRT	CRT	NNP
cord-259237-aty0vrat	60	30	and	and	CC
cord-259237-aty0vrat	60	31	re	re	NN
cord-259237-aty0vrat	60	32	-	-	NN
cord-259237-aty0vrat	60	33	entering	enter	VBG
cord-259237-aty0vrat	60	34	into	into	IN
cord-259237-aty0vrat	60	35	the	the	DT
cord-259237-aty0vrat	60	36	folding	folding	NN
cord-259237-aty0vrat	60	37	cycle	cycle	NN
cord-259237-aty0vrat	60	38	.	.	.
cord-259237-aty0vrat	61	1	Importantly	importantly	RB
cord-259237-aty0vrat	61	2	,	,	,
cord-259237-aty0vrat	61	3	the	the	DT
cord-259237-aty0vrat	61	4	low	low	JJ
cord-259237-aty0vrat	61	5	-	-	HYPH
cord-259237-aty0vrat	61	6	Man	man	NN
cord-259237-aty0vrat	61	7	N	n	NN
cord-259237-aty0vrat	61	8	-	-	HYPH
cord-259237-aty0vrat	61	9	glycans	glycan	NNS
cord-259237-aty0vrat	61	10	represent	represent	VBP
cord-259237-aty0vrat	61	11	a	a	DT
cord-259237-aty0vrat	61	12	tag	tag	NN
cord-259237-aty0vrat	61	13	for	for	IN
cord-259237-aty0vrat	61	14	defective	defective	JJ
cord-259237-aty0vrat	61	15	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	61	16	,	,	,
cord-259237-aty0vrat	61	17	targeting	target	VBG
cord-259237-aty0vrat	61	18	them	-PRON-	PRP
cord-259237-aty0vrat	61	19	to	to	IN
cord-259237-aty0vrat	61	20	ERAD	ERAD	NNP
cord-259237-aty0vrat	61	21	[	[	-LRB-
cord-259237-aty0vrat	61	22	26	26	CD
cord-259237-aty0vrat	61	23	]	]	-RRB-
cord-259237-aty0vrat	61	24	.	.	.
cord-259237-aty0vrat	62	1	,	,	,
cord-259237-aty0vrat	62	2	and	and	CC
cord-259237-aty0vrat	62	3	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	62	4	reticulum	reticulum	NN
cord-259237-aty0vrat	62	5	(	(	-LRB-
cord-259237-aty0vrat	62	6	ER	ER	NNP
cord-259237-aty0vrat	62	7	)	)	-RRB-
cord-259237-aty0vrat	62	8	stress	stress	NN
cord-259237-aty0vrat	62	9	pathways	pathway	NNS
cord-259237-aty0vrat	62	10	.	.	.
cord-259237-aty0vrat	63	1	Nascent	nascent	JJ
cord-259237-aty0vrat	63	2	polypeptides	polypeptide	NNS
cord-259237-aty0vrat	63	3	are	be	VBP
cord-259237-aty0vrat	63	4	translocated	translocate	VBN
cord-259237-aty0vrat	63	5	through	through	IN
cord-259237-aty0vrat	63	6	Sec61	Sec61	NNP
cord-259237-aty0vrat	63	7	into	into	IN
cord-259237-aty0vrat	63	8	the	the	DT
cord-259237-aty0vrat	63	9	rough	rough	JJ
cord-259237-aty0vrat	63	10	ER	er	NN
cord-259237-aty0vrat	63	11	,	,	,
cord-259237-aty0vrat	63	12	where	where	WRB
cord-259237-aty0vrat	63	13	the	the	DT
cord-259237-aty0vrat	63	14	core	core	NN
cord-259237-aty0vrat	63	15	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	63	16	is	be	VBZ
cord-259237-aty0vrat	63	17	transferred	transfer	VBN
cord-259237-aty0vrat	63	18	from	from	IN
cord-259237-aty0vrat	63	19	a	a	DT
cord-259237-aty0vrat	63	20	dolichol	dolichol	JJ
cord-259237-aty0vrat	63	21	phosphate	phosphate	NN
cord-259237-aty0vrat	63	22	onto	onto	IN
cord-259237-aty0vrat	63	23	asparagine	asparagine	JJ
cord-259237-aty0vrat	63	24	residues	residue	NNS
cord-259237-aty0vrat	63	25	in	in	IN
cord-259237-aty0vrat	63	26	asparagine	asparagine	NN
cord-259237-aty0vrat	63	27	-	-	HYPH
cord-259237-aty0vrat	63	28	X	x	NN
cord-259237-aty0vrat	63	29	-	-	NN
cord-259237-aty0vrat	63	30	serine	serine	NN
cord-259237-aty0vrat	63	31	/	/	SYM
cord-259237-aty0vrat	63	32	threonine	threonine	NN
cord-259237-aty0vrat	63	33	(	(	-LRB-
cord-259237-aty0vrat	63	34	NXS	NXS	NNP
cord-259237-aty0vrat	63	35	/	/	SYM
cord-259237-aty0vrat	63	36	T	T	NNP
cord-259237-aty0vrat	63	37	)	)	-RRB-
cord-259237-aty0vrat	63	38	motifs	motifs	NNP
cord-259237-aty0vrat	63	39	(	(	-LRB-
cord-259237-aty0vrat	63	40	I	i	NN
cord-259237-aty0vrat	63	41	)	)	-RRB-
cord-259237-aty0vrat	63	42	.	.	.
cord-259237-aty0vrat	64	1	The	the	DT
cord-259237-aty0vrat	64	2	two	two	CD
cord-259237-aty0vrat	64	3	terminal	terminal	NN
cord-259237-aty0vrat	64	4	glucose	glucose	NN
cord-259237-aty0vrat	64	5	residues	residue	NNS
cord-259237-aty0vrat	64	6	on	on	IN
cord-259237-aty0vrat	64	7	the	the	DT
cord-259237-aty0vrat	64	8	core	core	NN
cord-259237-aty0vrat	64	9	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	64	10	are	be	VBP
cord-259237-aty0vrat	64	11	trimmed	trim	VBN
cord-259237-aty0vrat	64	12	by	by	IN
cord-259237-aty0vrat	64	13	glucosidase	glucosidase	NNP
cord-259237-aty0vrat	65	1	I	-PRON-	PRP
cord-259237-aty0vrat	65	2	,	,	,
cord-259237-aty0vrat	65	3	(	(	-LRB-
cord-259237-aty0vrat	65	4	GI	GI	NNP
cord-259237-aty0vrat	65	5	)	)	-RRB-
cord-259237-aty0vrat	65	6	(	(	-LRB-
cord-259237-aty0vrat	65	7	II	II	NNP
cord-259237-aty0vrat	65	8	)	)	-RRB-
cord-259237-aty0vrat	65	9	,	,	,
cord-259237-aty0vrat	65	10	and	and	CC
cord-259237-aty0vrat	65	11	GII	GII	NNP
cord-259237-aty0vrat	65	12	(	(	-LRB-
cord-259237-aty0vrat	65	13	III	III	NNP
cord-259237-aty0vrat	65	14	)	)	-RRB-
cord-259237-aty0vrat	65	15	,	,	,
cord-259237-aty0vrat	65	16	respectively	respectively	RB
cord-259237-aty0vrat	65	17	,	,	,
cord-259237-aty0vrat	65	18	allowing	allow	VBG
cord-259237-aty0vrat	65	19	for	for	IN
cord-259237-aty0vrat	65	20	the	the	DT
cord-259237-aty0vrat	65	21	association	association	NN
cord-259237-aty0vrat	65	22	with	with	IN
cord-259237-aty0vrat	65	23	the	the	DT
cord-259237-aty0vrat	65	24	chaperones	chaperone	NNS
cord-259237-aty0vrat	65	25	,	,	,
cord-259237-aty0vrat	65	26	membrane	membrane	NN
cord-259237-aty0vrat	65	27	-	-	HYPH
cord-259237-aty0vrat	65	28	bound	bind	VBN
cord-259237-aty0vrat	65	29	calnexin	calnexin	NN
cord-259237-aty0vrat	65	30	(	(	-LRB-
cord-259237-aty0vrat	65	31	CNX	CNX	NNP
cord-259237-aty0vrat	65	32	)	)	-RRB-
cord-259237-aty0vrat	65	33	and	and	CC
cord-259237-aty0vrat	65	34	and/or	and/or	CC
cord-259237-aty0vrat	65	35	soluble	soluble	JJ
cord-259237-aty0vrat	65	36	calreticulin	calreticulin	NNP
cord-259237-aty0vrat	65	37	(	(	-LRB-
cord-259237-aty0vrat	65	38	CRT	CRT	NNP
cord-259237-aty0vrat	65	39	)	)	-RRB-
cord-259237-aty0vrat	65	40	,	,	,
cord-259237-aty0vrat	65	41	which	which	WDT
cord-259237-aty0vrat	65	42	promote	promote	VBP
cord-259237-aty0vrat	65	43	folding	folding	NN
cord-259237-aty0vrat	65	44	to	to	IN
cord-259237-aty0vrat	65	45	a	a	DT
cord-259237-aty0vrat	65	46	native	native	JJ
cord-259237-aty0vrat	65	47	conformation	conformation	NN
cord-259237-aty0vrat	65	48	.	.	.
cord-259237-aty0vrat	66	1	Eventually	eventually	RB
cord-259237-aty0vrat	66	2	,	,	,
cord-259237-aty0vrat	66	3	the	the	DT
cord-259237-aty0vrat	66	4	last	last	JJ
cord-259237-aty0vrat	66	5	terminal	terminal	NN
cord-259237-aty0vrat	66	6	glucose	glucose	NN
cord-259237-aty0vrat	66	7	residue	residue	NN
cord-259237-aty0vrat	66	8	will	will	MD
cord-259237-aty0vrat	66	9	be	be	VB
cord-259237-aty0vrat	66	10	trimmed	trim	VBN
cord-259237-aty0vrat	66	11	by	by	IN
cord-259237-aty0vrat	66	12	GII	GII	NNP
cord-259237-aty0vrat	66	13	,	,	,
cord-259237-aty0vrat	66	14	and	and	CC
cord-259237-aty0vrat	66	15	the	the	DT
cord-259237-aty0vrat	66	16	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	66	17	will	will	MD
cord-259237-aty0vrat	66	18	attain	attain	VB
cord-259237-aty0vrat	66	19	a	a	DT
cord-259237-aty0vrat	66	20	native	native	JJ
cord-259237-aty0vrat	66	21	conformation	conformation	NN
cord-259237-aty0vrat	66	22	(	(	-LRB-
cord-259237-aty0vrat	66	23	IV	IV	NNP
cord-259237-aty0vrat	66	24	)	)	-RRB-
cord-259237-aty0vrat	66	25	,	,	,
cord-259237-aty0vrat	66	26	or	or	CC
cord-259237-aty0vrat	66	27	misfold	misfold	VB
cord-259237-aty0vrat	66	28	(	(	-LRB-
cord-259237-aty0vrat	66	29	VII	VII	NNP
cord-259237-aty0vrat	66	30	)	)	-RRB-
cord-259237-aty0vrat	66	31	.	.	.
cord-259237-aty0vrat	67	1	Glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	67	2	that	that	WDT
cord-259237-aty0vrat	67	3	reach	reach	VBP
cord-259237-aty0vrat	67	4	a	a	DT
cord-259237-aty0vrat	67	5	native	native	JJ
cord-259237-aty0vrat	67	6	conformation	conformation	NN
cord-259237-aty0vrat	67	7	will	will	MD
cord-259237-aty0vrat	67	8	have	have	VB
cord-259237-aty0vrat	67	9	the	the	DT
cord-259237-aty0vrat	67	10	terminal	terminal	NN
cord-259237-aty0vrat	67	11	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	67	12	residue	residue	NN
cord-259237-aty0vrat	67	13	on	on	IN
cord-259237-aty0vrat	67	14	the	the	DT
cord-259237-aty0vrat	67	15	b	b	NN
cord-259237-aty0vrat	67	16	branch	branch	NN
cord-259237-aty0vrat	67	17	removed	remove	VBN
cord-259237-aty0vrat	67	18	by	by	IN
cord-259237-aty0vrat	67	19	ER	ER	NNP
cord-259237-aty0vrat	67	20	class	class	NN
cord-259237-aty0vrat	68	1	I	-PRON-	PRP
cord-259237-aty0vrat	68	2	α	α	NN
cord-259237-aty0vrat	68	3	-	-	HYPH
cord-259237-aty0vrat	68	4	mannosidase	mannosidase	NN
cord-259237-aty0vrat	68	5	(	(	-LRB-
cord-259237-aty0vrat	68	6	ERManI	ERManI	NNP
cord-259237-aty0vrat	68	7	)	)	-RRB-
cord-259237-aty0vrat	68	8	(	(	-LRB-
cord-259237-aty0vrat	68	9	V	V	NNP
cord-259237-aty0vrat	68	10	)	)	-RRB-
cord-259237-aty0vrat	68	11	,	,	,
cord-259237-aty0vrat	68	12	as	as	IN
cord-259237-aty0vrat	68	13	a	a	DT
cord-259237-aty0vrat	68	14	signal	signal	NN
cord-259237-aty0vrat	68	15	to	to	TO
cord-259237-aty0vrat	68	16	allow	allow	VB
cord-259237-aty0vrat	68	17	it	-PRON-	PRP
cord-259237-aty0vrat	68	18	to	to	TO
cord-259237-aty0vrat	68	19	traverse	traverse	VB
cord-259237-aty0vrat	68	20	the	the	DT
cord-259237-aty0vrat	68	21	canonical	canonical	JJ
cord-259237-aty0vrat	68	22	secretory	secretory	JJ
cord-259237-aty0vrat	68	23	pathway	pathway	NN
cord-259237-aty0vrat	68	24	for	for	IN
cord-259237-aty0vrat	68	25	surface	surface	NN
cord-259237-aty0vrat	68	26	presentation	presentation	NN
cord-259237-aty0vrat	68	27	or	or	CC
cord-259237-aty0vrat	68	28	secretion	secretion	NN
cord-259237-aty0vrat	68	29	(	(	-LRB-
cord-259237-aty0vrat	68	30	VI	VI	NNP
cord-259237-aty0vrat	68	31	)	)	-RRB-
cord-259237-aty0vrat	68	32	.	.	.
cord-259237-aty0vrat	69	1	Polypeptides	polypeptide	NNS
cord-259237-aty0vrat	69	2	unable	unable	JJ
cord-259237-aty0vrat	69	3	to	to	TO
cord-259237-aty0vrat	69	4	reach	reach	VB
cord-259237-aty0vrat	69	5	a	a	DT
cord-259237-aty0vrat	69	6	native	native	JJ
cord-259237-aty0vrat	69	7	conformation	conformation	NN
cord-259237-aty0vrat	69	8	(	(	-LRB-
cord-259237-aty0vrat	69	9	VII	VII	NNP
cord-259237-aty0vrat	69	10	)	)	-RRB-
cord-259237-aty0vrat	69	11	will	will	MD
cord-259237-aty0vrat	69	12	engage	engage	VB
cord-259237-aty0vrat	69	13	in	in	IN
cord-259237-aty0vrat	69	14	multiple	multiple	JJ
cord-259237-aty0vrat	69	15	rounds	round	NNS
cord-259237-aty0vrat	69	16	of	of	IN
cord-259237-aty0vrat	69	17	the	the	DT
cord-259237-aty0vrat	69	18	CNX	CNX	NNP
cord-259237-aty0vrat	69	19	/	/	SYM
cord-259237-aty0vrat	69	20	CRT	CRT	NNP
cord-259237-aty0vrat	69	21	cycle	cycle	NN
cord-259237-aty0vrat	69	22	,	,	,
cord-259237-aty0vrat	69	23	facilitated	facilitate	VBN
cord-259237-aty0vrat	69	24	by	by	IN
cord-259237-aty0vrat	69	25	reglucosylation	reglucosylation	NN
cord-259237-aty0vrat	69	26	of	of	IN
cord-259237-aty0vrat	69	27	the	the	DT
cord-259237-aty0vrat	69	28	terminal	terminal	JJ
cord-259237-aty0vrat	69	29	glucose	glucose	NN
cord-259237-aty0vrat	69	30	by	by	IN
cord-259237-aty0vrat	69	31	UDP	UDP	NNP
cord-259237-aty0vrat	69	32	-	-	HYPH
cord-259237-aty0vrat	69	33	Glc	Glc	NNP
cord-259237-aty0vrat	69	34	:	:	:
cord-259237-aty0vrat	69	35	unfolded	unfold	VBN
cord-259237-aty0vrat	69	36	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	69	37	glucosyltransferase	glucosyltransferase	NNP
cord-259237-aty0vrat	69	38	(	(	-LRB-
cord-259237-aty0vrat	69	39	UGGT	UGGT	NNP
cord-259237-aty0vrat	69	40	)	)	-RRB-
cord-259237-aty0vrat	69	41	(	(	-LRB-
cord-259237-aty0vrat	69	42	VIII	VIII	NNP
cord-259237-aty0vrat	69	43	)	)	-RRB-
cord-259237-aty0vrat	69	44	,	,	,
cord-259237-aty0vrat	69	45	and	and	CC
cord-259237-aty0vrat	69	46	trafficking	trafficking	NN
cord-259237-aty0vrat	69	47	between	between	IN
cord-259237-aty0vrat	69	48	quality	quality	NN
cord-259237-aty0vrat	69	49	control	control	NN
cord-259237-aty0vrat	69	50	vesicles	vesicle	NNS
cord-259237-aty0vrat	69	51	(	(	-LRB-
cord-259237-aty0vrat	69	52	QCV	QCV	NNP
cord-259237-aty0vrat	69	53	)	)	-RRB-
cord-259237-aty0vrat	69	54	(	(	-LRB-
cord-259237-aty0vrat	69	55	IX	IX	NNP
cord-259237-aty0vrat	69	56	)	)	-RRB-
cord-259237-aty0vrat	69	57	and	and	CC
cord-259237-aty0vrat	69	58	the	the	DT
cord-259237-aty0vrat	69	59	the	the	DT
cord-259237-aty0vrat	69	60	ER	er	NN
cord-259237-aty0vrat	69	61	-	-	HYPH
cord-259237-aty0vrat	69	62	derived	derive	VBN
cord-259237-aty0vrat	69	63	quality	quality	NN
cord-259237-aty0vrat	69	64	compartments	compartment	NNS
cord-259237-aty0vrat	69	65	(	(	-LRB-
cord-259237-aty0vrat	69	66	ERQC	ERQC	NNP
cord-259237-aty0vrat	69	67	)	)	-RRB-
cord-259237-aty0vrat	69	68	(	(	-LRB-
cord-259237-aty0vrat	69	69	X	x	NN
cord-259237-aty0vrat	69	70	)	)	-RRB-
cord-259237-aty0vrat	69	71	under	under	IN
cord-259237-aty0vrat	69	72	ER	ER	NNP
cord-259237-aty0vrat	69	73	stress	stress	NN
cord-259237-aty0vrat	69	74	.	.	.
cord-259237-aty0vrat	70	1	Terminally	terminally	RB
cord-259237-aty0vrat	70	2	misfolded	misfolde	VBN
cord-259237-aty0vrat	70	3	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	70	4	will	will	MD
cord-259237-aty0vrat	70	5	be	be	VB
cord-259237-aty0vrat	70	6	demannosylated	demannosylated	JJ
cord-259237-aty0vrat	70	7	to	to	TO
cord-259237-aty0vrat	70	8	remove	remove	VB
cord-259237-aty0vrat	70	9	all	all	DT
cord-259237-aty0vrat	70	10	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	70	11	residues	residue	NNS
cord-259237-aty0vrat	70	12	(	(	-LRB-
cord-259237-aty0vrat	70	13	XI	XI	NNP
cord-259237-aty0vrat	70	14	)	)	-RRB-
cord-259237-aty0vrat	70	15	,	,	,
cord-259237-aty0vrat	70	16	followed	follow	VBN
cord-259237-aty0vrat	70	17	by	by	IN
cord-259237-aty0vrat	70	18	association	association	NN
cord-259237-aty0vrat	70	19	with	with	IN
cord-259237-aty0vrat	70	20	lectins	lectin	NNS
cord-259237-aty0vrat	70	21	osteosarcoma	osteosarcoma	NN
cord-259237-aty0vrat	70	22	amplified	amplify	VBD
cord-259237-aty0vrat	70	23	9	9	CD
cord-259237-aty0vrat	70	24	(	(	-LRB-
cord-259237-aty0vrat	70	25	OS9	OS9	NNP
cord-259237-aty0vrat	70	26	)	)	-RRB-
cord-259237-aty0vrat	70	27	and	and	CC
cord-259237-aty0vrat	70	28	XTP3-transactivated	XTP3-transactivated	NNP
cord-259237-aty0vrat	70	29	gene	gene	NN
cord-259237-aty0vrat	70	30	B	B	NNP
cord-259237-aty0vrat	70	31	protein	protein	NN
cord-259237-aty0vrat	70	32	(	(	-LRB-
cord-259237-aty0vrat	70	33	XTP3-B	XTP3-B	NNP
cord-259237-aty0vrat	70	34	)	)	-RRB-
cord-259237-aty0vrat	70	35	for	for	IN
cord-259237-aty0vrat	70	36	ERAD	ERAD	NNP
cord-259237-aty0vrat	70	37	(	(	-LRB-
cord-259237-aty0vrat	70	38	XII	XII	NNP
cord-259237-aty0vrat	70	39	)	)	-RRB-
cord-259237-aty0vrat	70	40	.	.	.
cord-259237-aty0vrat	71	1	Figure	figure	NN
cord-259237-aty0vrat	71	2	1	1	CD
cord-259237-aty0vrat	71	3	.	.	.
cord-259237-aty0vrat	72	1	(	(	-LRB-
cord-259237-aty0vrat	72	2	A	a	DT
cord-259237-aty0vrat	72	3	)	)	-RRB-
cord-259237-aty0vrat	72	4	Schematic	schematic	JJ
cord-259237-aty0vrat	72	5	presentation	presentation	NN
cord-259237-aty0vrat	72	6	of	of	IN
cord-259237-aty0vrat	72	7	the	the	DT
cord-259237-aty0vrat	72	8	N	N	NNP
cord-259237-aty0vrat	72	9	-	-	HYPH
cord-259237-aty0vrat	72	10	linked	link	VBN
cord-259237-aty0vrat	72	11	core	core	NN
cord-259237-aty0vrat	72	12	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	72	13	structure	structure	NN
cord-259237-aty0vrat	72	14	.	.	.
cord-259237-aty0vrat	73	1	The	the	DT
cord-259237-aty0vrat	73	2	core	core	NN
cord-259237-aty0vrat	73	3	is	be	VBZ
cord-259237-aty0vrat	73	4	composed	compose	VBN
cord-259237-aty0vrat	73	5	of	of	IN
cord-259237-aty0vrat	73	6	two	two	CD
cord-259237-aty0vrat	73	7	N	N	NNP
cord-259237-aty0vrat	73	8	-	-	HYPH
cord-259237-aty0vrat	73	9	acetylglucosamine	acetylglucosamine	NNP
cord-259237-aty0vrat	73	10	(	(	-LRB-
cord-259237-aty0vrat	73	11	GlcNAc	GlcNAc	NNP
cord-259237-aty0vrat	73	12	,	,	,
cord-259237-aty0vrat	73	13	blue	blue	NNP
cord-259237-aty0vrat	73	14	)	)	-RRB-
cord-259237-aty0vrat	73	15	,	,	,
cord-259237-aty0vrat	73	16	nine	nine	CD
cord-259237-aty0vrat	73	17	mannose	mannose	NN
cord-259237-aty0vrat	73	18	(	(	-LRB-
cord-259237-aty0vrat	73	19	Man	man	NN
cord-259237-aty0vrat	73	20	,	,	,
cord-259237-aty0vrat	73	21	red	red	JJ
cord-259237-aty0vrat	73	22	)	)	-RRB-
cord-259237-aty0vrat	73	23	,	,	,
cord-259237-aty0vrat	73	24	and	and	CC
cord-259237-aty0vrat	73	25	three	three	CD
cord-259237-aty0vrat	73	26	glucose	glucose	NN
cord-259237-aty0vrat	73	27	(	(	-LRB-
cord-259237-aty0vrat	73	28	Glc	Glc	NNP
cord-259237-aty0vrat	73	29	,	,	,
cord-259237-aty0vrat	73	30	yellow	yellow	JJ
cord-259237-aty0vrat	73	31	)	)	-RRB-
cord-259237-aty0vrat	73	32	residues	residue	NNS
cord-259237-aty0vrat	73	33	.	.	.
cord-259237-aty0vrat	74	1	a	a	LS
cord-259237-aty0vrat	74	2	,	,	,
cord-259237-aty0vrat	74	3	b	b	NN
cord-259237-aty0vrat	74	4	,	,	,
cord-259237-aty0vrat	74	5	and	and	CC
cord-259237-aty0vrat	74	6	c	c	NN
cord-259237-aty0vrat	74	7	are	be	VBP
cord-259237-aty0vrat	74	8	three	three	CD
cord-259237-aty0vrat	74	9	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	74	10	branches	branch	NNS
cord-259237-aty0vrat	74	11	.	.	.
cord-259237-aty0vrat	75	1	(	(	-LRB-
cord-259237-aty0vrat	75	2	B	b	NN
cord-259237-aty0vrat	75	3	)	)	-RRB-
cord-259237-aty0vrat	75	4	Schematic	schematic	JJ
cord-259237-aty0vrat	75	5	description	description	NN
cord-259237-aty0vrat	75	6	of	of	IN
cord-259237-aty0vrat	75	7	N	n	NN
cord-259237-aty0vrat	75	8	-	-	HYPH
cord-259237-aty0vrat	75	9	glycosylation	glycosylation	NN
cord-259237-aty0vrat	75	10	,	,	,
cord-259237-aty0vrat	75	11	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	75	12	reticulum	reticulum	NN
cord-259237-aty0vrat	75	13	-	-	HYPH
cord-259237-aty0vrat	75	14	associated	associate	VBN
cord-259237-aty0vrat	75	15	protein	protein	NN
cord-259237-aty0vrat	75	16	degradation	degradation	NN
cord-259237-aty0vrat	75	17	(	(	-LRB-
cord-259237-aty0vrat	75	18	ERAD	ERAD	NNP
cord-259237-aty0vrat	75	19	)	)	-RRB-
cord-259237-aty0vrat	75	20	,	,	,
cord-259237-aty0vrat	75	21	and	and	CC
cord-259237-aty0vrat	75	22	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	75	23	reticulum	reticulum	NN
cord-259237-aty0vrat	75	24	(	(	-LRB-
cord-259237-aty0vrat	75	25	ER	ER	NNP
cord-259237-aty0vrat	75	26	)	)	-RRB-
cord-259237-aty0vrat	75	27	stress	stress	NN
cord-259237-aty0vrat	75	28	pathways	pathway	NNS
cord-259237-aty0vrat	75	29	.	.	.
cord-259237-aty0vrat	76	1	Nascent	nascent	JJ
cord-259237-aty0vrat	76	2	polypeptides	polypeptide	NNS
cord-259237-aty0vrat	76	3	are	be	VBP
cord-259237-aty0vrat	76	4	translocated	translocate	VBN
cord-259237-aty0vrat	76	5	through	through	IN
cord-259237-aty0vrat	76	6	Sec61	Sec61	NNP
cord-259237-aty0vrat	76	7	into	into	IN
cord-259237-aty0vrat	76	8	the	the	DT
cord-259237-aty0vrat	76	9	rough	rough	JJ
cord-259237-aty0vrat	76	10	ER	er	NN
cord-259237-aty0vrat	76	11	,	,	,
cord-259237-aty0vrat	76	12	where	where	WRB
cord-259237-aty0vrat	76	13	the	the	DT
cord-259237-aty0vrat	76	14	core	core	NN
cord-259237-aty0vrat	76	15	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	76	16	is	be	VBZ
cord-259237-aty0vrat	76	17	transferred	transfer	VBN
cord-259237-aty0vrat	76	18	from	from	IN
cord-259237-aty0vrat	76	19	a	a	DT
cord-259237-aty0vrat	76	20	dolichol	dolichol	JJ
cord-259237-aty0vrat	76	21	phosphate	phosphate	NN
cord-259237-aty0vrat	76	22	onto	onto	IN
cord-259237-aty0vrat	76	23	asparagine	asparagine	JJ
cord-259237-aty0vrat	76	24	residues	residue	NNS
cord-259237-aty0vrat	76	25	in	in	IN
cord-259237-aty0vrat	76	26	asparagine	asparagine	NN
cord-259237-aty0vrat	76	27	-	-	HYPH
cord-259237-aty0vrat	76	28	X	x	NN
cord-259237-aty0vrat	76	29	-	-	NN
cord-259237-aty0vrat	76	30	serine	serine	NN
cord-259237-aty0vrat	76	31	/	/	SYM
cord-259237-aty0vrat	76	32	threonine	threonine	NN
cord-259237-aty0vrat	76	33	(	(	-LRB-
cord-259237-aty0vrat	76	34	NXS	NXS	NNP
cord-259237-aty0vrat	76	35	/	/	SYM
cord-259237-aty0vrat	76	36	T	T	NNP
cord-259237-aty0vrat	76	37	)	)	-RRB-
cord-259237-aty0vrat	76	38	motifs	motifs	NNP
cord-259237-aty0vrat	76	39	(	(	-LRB-
cord-259237-aty0vrat	76	40	I	i	NN
cord-259237-aty0vrat	76	41	)	)	-RRB-
cord-259237-aty0vrat	76	42	.	.	.
cord-259237-aty0vrat	77	1	The	the	DT
cord-259237-aty0vrat	77	2	two	two	CD
cord-259237-aty0vrat	77	3	terminal	terminal	NN
cord-259237-aty0vrat	77	4	glucose	glucose	NN
cord-259237-aty0vrat	77	5	residues	residue	NNS
cord-259237-aty0vrat	77	6	on	on	IN
cord-259237-aty0vrat	77	7	the	the	DT
cord-259237-aty0vrat	77	8	core	core	NN
cord-259237-aty0vrat	77	9	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	77	10	are	be	VBP
cord-259237-aty0vrat	77	11	trimmed	trim	VBN
cord-259237-aty0vrat	77	12	by	by	IN
cord-259237-aty0vrat	77	13	glucosidase	glucosidase	NNP
cord-259237-aty0vrat	78	1	I	-PRON-	PRP
cord-259237-aty0vrat	78	2	,	,	,
cord-259237-aty0vrat	78	3	(	(	-LRB-
cord-259237-aty0vrat	78	4	GI	GI	NNP
cord-259237-aty0vrat	78	5	)	)	-RRB-
cord-259237-aty0vrat	78	6	(	(	-LRB-
cord-259237-aty0vrat	78	7	II	II	NNP
cord-259237-aty0vrat	78	8	)	)	-RRB-
cord-259237-aty0vrat	78	9	,	,	,
cord-259237-aty0vrat	78	10	and	and	CC
cord-259237-aty0vrat	78	11	GII	GII	NNP
cord-259237-aty0vrat	78	12	(	(	-LRB-
cord-259237-aty0vrat	78	13	III	III	NNP
cord-259237-aty0vrat	78	14	)	)	-RRB-
cord-259237-aty0vrat	78	15	,	,	,
cord-259237-aty0vrat	78	16	respectively	respectively	RB
cord-259237-aty0vrat	78	17	,	,	,
cord-259237-aty0vrat	78	18	allowing	allow	VBG
cord-259237-aty0vrat	78	19	for	for	IN
cord-259237-aty0vrat	78	20	the	the	DT
cord-259237-aty0vrat	78	21	association	association	NN
cord-259237-aty0vrat	78	22	with	with	IN
cord-259237-aty0vrat	78	23	the	the	DT
cord-259237-aty0vrat	78	24	chaperones	chaperone	NNS
cord-259237-aty0vrat	78	25	,	,	,
cord-259237-aty0vrat	78	26	membrane	membrane	NN
cord-259237-aty0vrat	78	27	-	-	HYPH
cord-259237-aty0vrat	78	28	bound	bind	VBN
cord-259237-aty0vrat	78	29	calnexin	calnexin	NN
cord-259237-aty0vrat	78	30	(	(	-LRB-
cord-259237-aty0vrat	78	31	CNX	CNX	NNP
cord-259237-aty0vrat	78	32	)	)	-RRB-
cord-259237-aty0vrat	78	33	and	and	CC
cord-259237-aty0vrat	78	34	and/or	and/or	CC
cord-259237-aty0vrat	78	35	soluble	soluble	JJ
cord-259237-aty0vrat	78	36	calreticulin	calreticulin	NNP
cord-259237-aty0vrat	78	37	(	(	-LRB-
cord-259237-aty0vrat	78	38	CRT	CRT	NNP
cord-259237-aty0vrat	78	39	)	)	-RRB-
cord-259237-aty0vrat	78	40	,	,	,
cord-259237-aty0vrat	78	41	which	which	WDT
cord-259237-aty0vrat	78	42	promote	promote	VBP
cord-259237-aty0vrat	78	43	folding	folding	NN
cord-259237-aty0vrat	78	44	to	to	IN
cord-259237-aty0vrat	78	45	a	a	DT
cord-259237-aty0vrat	78	46	native	native	JJ
cord-259237-aty0vrat	78	47	conformation	conformation	NN
cord-259237-aty0vrat	78	48	.	.	.
cord-259237-aty0vrat	79	1	Eventually	eventually	RB
cord-259237-aty0vrat	79	2	,	,	,
cord-259237-aty0vrat	79	3	the	the	DT
cord-259237-aty0vrat	79	4	last	last	JJ
cord-259237-aty0vrat	79	5	terminal	terminal	NN
cord-259237-aty0vrat	79	6	glucose	glucose	NN
cord-259237-aty0vrat	79	7	residue	residue	NN
cord-259237-aty0vrat	79	8	will	will	MD
cord-259237-aty0vrat	79	9	be	be	VB
cord-259237-aty0vrat	79	10	trimmed	trim	VBN
cord-259237-aty0vrat	79	11	by	by	IN
cord-259237-aty0vrat	79	12	GII	GII	NNP
cord-259237-aty0vrat	79	13	,	,	,
cord-259237-aty0vrat	79	14	and	and	CC
cord-259237-aty0vrat	79	15	the	the	DT
cord-259237-aty0vrat	79	16	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	79	17	will	will	MD
cord-259237-aty0vrat	79	18	attain	attain	VB
cord-259237-aty0vrat	79	19	a	a	DT
cord-259237-aty0vrat	79	20	native	native	JJ
cord-259237-aty0vrat	79	21	conformation	conformation	NN
cord-259237-aty0vrat	79	22	(	(	-LRB-
cord-259237-aty0vrat	79	23	IV	IV	NNP
cord-259237-aty0vrat	79	24	)	)	-RRB-
cord-259237-aty0vrat	79	25	,	,	,
cord-259237-aty0vrat	79	26	or	or	CC
cord-259237-aty0vrat	79	27	misfold	misfold	VB
cord-259237-aty0vrat	79	28	(	(	-LRB-
cord-259237-aty0vrat	79	29	VII	VII	NNP
cord-259237-aty0vrat	79	30	)	)	-RRB-
cord-259237-aty0vrat	79	31	.	.	.
cord-259237-aty0vrat	80	1	Glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	80	2	that	that	WDT
cord-259237-aty0vrat	80	3	reach	reach	VBP
cord-259237-aty0vrat	80	4	a	a	DT
cord-259237-aty0vrat	80	5	native	native	JJ
cord-259237-aty0vrat	80	6	conformation	conformation	NN
cord-259237-aty0vrat	80	7	will	will	MD
cord-259237-aty0vrat	80	8	have	have	VB
cord-259237-aty0vrat	80	9	the	the	DT
cord-259237-aty0vrat	80	10	terminal	terminal	NN
cord-259237-aty0vrat	80	11	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	80	12	residue	residue	NN
cord-259237-aty0vrat	80	13	on	on	IN
cord-259237-aty0vrat	80	14	the	the	DT
cord-259237-aty0vrat	80	15	b	b	NN
cord-259237-aty0vrat	80	16	branch	branch	NN
cord-259237-aty0vrat	80	17	removed	remove	VBN
cord-259237-aty0vrat	80	18	by	by	IN
cord-259237-aty0vrat	80	19	ER	ER	NNP
cord-259237-aty0vrat	80	20	class	class	NN
cord-259237-aty0vrat	81	1	I	-PRON-	PRP
cord-259237-aty0vrat	81	2	α	α	NN
cord-259237-aty0vrat	81	3	-	-	HYPH
cord-259237-aty0vrat	81	4	mannosidase	mannosidase	NN
cord-259237-aty0vrat	81	5	(	(	-LRB-
cord-259237-aty0vrat	81	6	ERManI	ERManI	NNP
cord-259237-aty0vrat	81	7	)	)	-RRB-
cord-259237-aty0vrat	81	8	(	(	-LRB-
cord-259237-aty0vrat	81	9	V	V	NNP
cord-259237-aty0vrat	81	10	)	)	-RRB-
cord-259237-aty0vrat	81	11	,	,	,
cord-259237-aty0vrat	81	12	as	as	IN
cord-259237-aty0vrat	81	13	a	a	DT
cord-259237-aty0vrat	81	14	signal	signal	NN
cord-259237-aty0vrat	81	15	to	to	TO
cord-259237-aty0vrat	81	16	allow	allow	VB
cord-259237-aty0vrat	81	17	it	-PRON-	PRP
cord-259237-aty0vrat	81	18	to	to	TO
cord-259237-aty0vrat	81	19	traverse	traverse	VB
cord-259237-aty0vrat	81	20	the	the	DT
cord-259237-aty0vrat	81	21	canonical	canonical	JJ
cord-259237-aty0vrat	81	22	secretory	secretory	JJ
cord-259237-aty0vrat	81	23	pathway	pathway	NN
cord-259237-aty0vrat	81	24	for	for	IN
cord-259237-aty0vrat	81	25	surface	surface	NN
cord-259237-aty0vrat	81	26	presentation	presentation	NN
cord-259237-aty0vrat	81	27	or	or	CC
cord-259237-aty0vrat	81	28	secretion	secretion	NN
cord-259237-aty0vrat	81	29	(	(	-LRB-
cord-259237-aty0vrat	81	30	VI	VI	NNP
cord-259237-aty0vrat	81	31	)	)	-RRB-
cord-259237-aty0vrat	81	32	.	.	.
cord-259237-aty0vrat	82	1	Polypeptides	polypeptide	NNS
cord-259237-aty0vrat	82	2	unable	unable	JJ
cord-259237-aty0vrat	82	3	to	to	TO
cord-259237-aty0vrat	82	4	reach	reach	VB
cord-259237-aty0vrat	82	5	a	a	DT
cord-259237-aty0vrat	82	6	native	native	JJ
cord-259237-aty0vrat	82	7	conformation	conformation	NN
cord-259237-aty0vrat	82	8	(	(	-LRB-
cord-259237-aty0vrat	82	9	VII	VII	NNP
cord-259237-aty0vrat	82	10	)	)	-RRB-
cord-259237-aty0vrat	82	11	will	will	MD
cord-259237-aty0vrat	82	12	engage	engage	VB
cord-259237-aty0vrat	82	13	in	in	IN
cord-259237-aty0vrat	82	14	multiple	multiple	JJ
cord-259237-aty0vrat	82	15	rounds	round	NNS
cord-259237-aty0vrat	82	16	of	of	IN
cord-259237-aty0vrat	82	17	the	the	DT
cord-259237-aty0vrat	82	18	CNX	CNX	NNP
cord-259237-aty0vrat	82	19	/	/	SYM
cord-259237-aty0vrat	82	20	CRT	CRT	NNP
cord-259237-aty0vrat	82	21	cycle	cycle	NN
cord-259237-aty0vrat	82	22	,	,	,
cord-259237-aty0vrat	82	23	facilitated	facilitate	VBN
cord-259237-aty0vrat	82	24	by	by	IN
cord-259237-aty0vrat	82	25	reglucosylation	reglucosylation	NN
cord-259237-aty0vrat	82	26	of	of	IN
cord-259237-aty0vrat	82	27	the	the	DT
cord-259237-aty0vrat	82	28	terminal	terminal	JJ
cord-259237-aty0vrat	82	29	glucose	glucose	NN
cord-259237-aty0vrat	82	30	by	by	IN
cord-259237-aty0vrat	82	31	UDP	UDP	NNP
cord-259237-aty0vrat	82	32	-	-	HYPH
cord-259237-aty0vrat	82	33	Glc	Glc	NNP
cord-259237-aty0vrat	82	34	:	:	:
cord-259237-aty0vrat	82	35	unfolded	unfold	VBN
cord-259237-aty0vrat	82	36	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	82	37	glucosyltransferase	glucosyltransferase	NNP
cord-259237-aty0vrat	82	38	(	(	-LRB-
cord-259237-aty0vrat	82	39	UGGT	UGGT	NNP
cord-259237-aty0vrat	82	40	)	)	-RRB-
cord-259237-aty0vrat	82	41	(	(	-LRB-
cord-259237-aty0vrat	82	42	VIII	VIII	NNP
cord-259237-aty0vrat	82	43	)	)	-RRB-
cord-259237-aty0vrat	82	44	,	,	,
cord-259237-aty0vrat	82	45	and	and	CC
cord-259237-aty0vrat	82	46	trafficking	trafficking	NN
cord-259237-aty0vrat	82	47	between	between	IN
cord-259237-aty0vrat	82	48	quality	quality	NN
cord-259237-aty0vrat	82	49	control	control	NN
cord-259237-aty0vrat	82	50	vesicles	vesicle	NNS
cord-259237-aty0vrat	82	51	(	(	-LRB-
cord-259237-aty0vrat	82	52	QCV	QCV	NNP
cord-259237-aty0vrat	82	53	)	)	-RRB-
cord-259237-aty0vrat	82	54	(	(	-LRB-
cord-259237-aty0vrat	82	55	IX	IX	NNP
cord-259237-aty0vrat	82	56	)	)	-RRB-
cord-259237-aty0vrat	82	57	and	and	CC
cord-259237-aty0vrat	82	58	the	the	DT
cord-259237-aty0vrat	82	59	the	the	DT
cord-259237-aty0vrat	82	60	ER	er	NN
cord-259237-aty0vrat	82	61	-	-	HYPH
cord-259237-aty0vrat	82	62	derived	derive	VBN
cord-259237-aty0vrat	82	63	quality	quality	NN
cord-259237-aty0vrat	82	64	compartments	compartment	NNS
cord-259237-aty0vrat	82	65	(	(	-LRB-
cord-259237-aty0vrat	82	66	ERQC	ERQC	NNP
cord-259237-aty0vrat	82	67	)	)	-RRB-
cord-259237-aty0vrat	82	68	(	(	-LRB-
cord-259237-aty0vrat	82	69	X	x	NN
cord-259237-aty0vrat	82	70	)	)	-RRB-
cord-259237-aty0vrat	82	71	under	under	IN
cord-259237-aty0vrat	82	72	ER	ER	NNP
cord-259237-aty0vrat	82	73	stress	stress	NN
cord-259237-aty0vrat	82	74	.	.	.
cord-259237-aty0vrat	83	1	Terminally	terminally	RB
cord-259237-aty0vrat	83	2	misfolded	misfolde	VBN
cord-259237-aty0vrat	83	3	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	83	4	will	will	MD
cord-259237-aty0vrat	83	5	be	be	VB
cord-259237-aty0vrat	83	6	demannosylated	demannosylated	JJ
cord-259237-aty0vrat	83	7	to	to	TO
cord-259237-aty0vrat	83	8	remove	remove	VB
cord-259237-aty0vrat	83	9	all	all	DT
cord-259237-aty0vrat	83	10	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	83	11	residues	residue	NNS
cord-259237-aty0vrat	83	12	(	(	-LRB-
cord-259237-aty0vrat	83	13	XI	XI	NNP
cord-259237-aty0vrat	83	14	)	)	-RRB-
cord-259237-aty0vrat	83	15	,	,	,
cord-259237-aty0vrat	83	16	followed	follow	VBN
cord-259237-aty0vrat	83	17	by	by	IN
cord-259237-aty0vrat	83	18	association	association	NN
cord-259237-aty0vrat	83	19	with	with	IN
cord-259237-aty0vrat	83	20	lectins	lectin	NNS
cord-259237-aty0vrat	83	21	osteosarcoma	osteosarcoma	NN
cord-259237-aty0vrat	83	22	amplified	amplify	VBD
cord-259237-aty0vrat	83	23	9	9	CD
cord-259237-aty0vrat	83	24	(	(	-LRB-
cord-259237-aty0vrat	83	25	OS9	OS9	NNP
cord-259237-aty0vrat	83	26	)	)	-RRB-
cord-259237-aty0vrat	83	27	and	and	CC
cord-259237-aty0vrat	83	28	XTP3-transactivated	XTP3-transactivated	NNP
cord-259237-aty0vrat	83	29	gene	gene	NN
cord-259237-aty0vrat	83	30	B	B	NNP
cord-259237-aty0vrat	83	31	protein	protein	NN
cord-259237-aty0vrat	83	32	(	(	-LRB-
cord-259237-aty0vrat	83	33	XTP3-B	XTP3-B	NNP
cord-259237-aty0vrat	83	34	)	)	-RRB-
cord-259237-aty0vrat	83	35	for	for	IN
cord-259237-aty0vrat	83	36	ERAD	ERAD	NNP
cord-259237-aty0vrat	83	37	(	(	-LRB-
cord-259237-aty0vrat	83	38	XII	XII	NNP
cord-259237-aty0vrat	83	39	)	)	-RRB-
cord-259237-aty0vrat	83	40	.	.	.
cord-259237-aty0vrat	84	1	ERManI	ERManI	NNP
cord-259237-aty0vrat	84	2	containing	contain	VBG
cord-259237-aty0vrat	84	3	QCV	QCV	NNP
cord-259237-aty0vrat	84	4	are	be	VBP
cord-259237-aty0vrat	84	5	rapidly	rapidly	RB
cord-259237-aty0vrat	84	6	recycled	recycle	VBN
cord-259237-aty0vrat	84	7	through	through	IN
cord-259237-aty0vrat	84	8	autophagy	autophagy	NN
cord-259237-aty0vrat	84	9	/	/	SYM
cord-259237-aty0vrat	84	10	lysosome	lysosome	NN
cord-259237-aty0vrat	84	11	pathways	pathway	NNS
cord-259237-aty0vrat	84	12	(	(	-LRB-
cord-259237-aty0vrat	84	13	XIII	XIII	NNP
cord-259237-aty0vrat	84	14	)	)	-RRB-
cord-259237-aty0vrat	84	15	.	.	.
cord-259237-aty0vrat	85	1	Without	without	IN
cord-259237-aty0vrat	85	2	interactions	interaction	NNS
cord-259237-aty0vrat	85	3	with	with	IN
cord-259237-aty0vrat	85	4	client	client	NN
cord-259237-aty0vrat	85	5	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	85	6	,	,	,
cord-259237-aty0vrat	85	7	EDEMosome	edemosome	NN
cord-259237-aty0vrat	85	8	components	component	NNS
cord-259237-aty0vrat	85	9	are	be	VBP
cord-259237-aty0vrat	85	10	degraded	degrade	VBN
cord-259237-aty0vrat	85	11	through	through	IN
cord-259237-aty0vrat	85	12	an	an	DT
cord-259237-aty0vrat	85	13	autophagy	autophagy	NN
cord-259237-aty0vrat	85	14	-	-	HYPH
cord-259237-aty0vrat	85	15	like	like	JJ
cord-259237-aty0vrat	85	16	mechanism	mechanism	NN
cord-259237-aty0vrat	85	17	(	(	-LRB-
cord-259237-aty0vrat	85	18	XIV	XIV	NNP
cord-259237-aty0vrat	85	19	)	)	-RRB-
cord-259237-aty0vrat	85	20	.	.	.
cord-259237-aty0vrat	86	1	Viruses	virus	NNS
cord-259237-aty0vrat	86	2	can	can	MD
cord-259237-aty0vrat	86	3	hijack	hijack	VB
cord-259237-aty0vrat	86	4	EDEMosomes	edemosome	NNS
cord-259237-aty0vrat	86	5	to	to	TO
cord-259237-aty0vrat	86	6	form	form	VB
cord-259237-aty0vrat	86	7	double	double	JJ
cord-259237-aty0vrat	86	8	membrane	membrane	NN
cord-259237-aty0vrat	86	9	vesicles	vesicle	NNS
cord-259237-aty0vrat	86	10	(	(	-LRB-
cord-259237-aty0vrat	86	11	DMVs	dmv	NNS
cord-259237-aty0vrat	86	12	)	)	-RRB-
cord-259237-aty0vrat	86	13	that	that	WDT
cord-259237-aty0vrat	86	14	serve	serve	VBP
cord-259237-aty0vrat	86	15	as	as	IN
cord-259237-aty0vrat	86	16	platforms	platform	NNS
cord-259237-aty0vrat	86	17	for	for	IN
cord-259237-aty0vrat	86	18	their	-PRON-	PRP$
cord-259237-aty0vrat	86	19	replication	replication	NN
cord-259237-aty0vrat	86	20	(	(	-LRB-
cord-259237-aty0vrat	86	21	XV	XV	NNP
cord-259237-aty0vrat	86	22	)	)	-RRB-
cord-259237-aty0vrat	86	23	.	.	.
cord-259237-aty0vrat	87	1	With	with	IN
cord-259237-aty0vrat	87	2	only	only	RB
cord-259237-aty0vrat	87	3	one	one	CD
cord-259237-aty0vrat	87	4	-	-	HYPH
cord-259237-aty0vrat	87	5	tenth	tenth	NN
cord-259237-aty0vrat	87	6	of	of	IN
cord-259237-aty0vrat	87	7	the	the	DT
cord-259237-aty0vrat	87	8	total	total	JJ
cord-259237-aty0vrat	87	9	cell	cell	NN
cord-259237-aty0vrat	87	10	volume	volume	NN
cord-259237-aty0vrat	87	11	,	,	,
cord-259237-aty0vrat	87	12	the	the	DT
cord-259237-aty0vrat	87	13	ER	ER	NNP
cord-259237-aty0vrat	87	14	is	be	VBZ
cord-259237-aty0vrat	87	15	responsible	responsible	JJ
cord-259237-aty0vrat	87	16	for	for	IN
cord-259237-aty0vrat	87	17	the	the	DT
cord-259237-aty0vrat	87	18	synthesis	synthesis	NN
cord-259237-aty0vrat	87	19	of	of	IN
cord-259237-aty0vrat	87	20	the	the	DT
cord-259237-aty0vrat	87	21	vast	vast	JJ
cord-259237-aty0vrat	87	22	majority	majority	NN
cord-259237-aty0vrat	87	23	of	of	IN
cord-259237-aty0vrat	87	24	the	the	DT
cord-259237-aty0vrat	87	25	secreted	secrete	VBN
cord-259237-aty0vrat	87	26	or	or	CC
cord-259237-aty0vrat	87	27	membrane	membrane	NN
cord-259237-aty0vrat	87	28	proteins	protein	NNS
cord-259237-aty0vrat	87	29	,	,	,
cord-259237-aty0vrat	87	30	which	which	WDT
cord-259237-aty0vrat	87	31	account	account	VBP
cord-259237-aty0vrat	87	32	for	for	IN
cord-259237-aty0vrat	87	33	one	one	CD
cord-259237-aty0vrat	87	34	-	-	HYPH
cord-259237-aty0vrat	87	35	third	third	NN
cord-259237-aty0vrat	87	36	of	of	IN
cord-259237-aty0vrat	87	37	total	total	JJ
cord-259237-aty0vrat	87	38	cellular	cellular	JJ
cord-259237-aty0vrat	87	39	proteins	protein	NNS
cord-259237-aty0vrat	87	40	.	.	.
cord-259237-aty0vrat	88	1	Therefore	therefore	RB
cord-259237-aty0vrat	88	2	,	,	,
cord-259237-aty0vrat	88	3	the	the	DT
cord-259237-aty0vrat	88	4	ER	ER	NNP
cord-259237-aty0vrat	88	5	has	have	VBZ
cord-259237-aty0vrat	88	6	extremely	extremely	RB
cord-259237-aty0vrat	88	7	high	high	JJ
cord-259237-aty0vrat	88	8	protein	protein	NN
cord-259237-aty0vrat	88	9	concentrations	concentration	NNS
cord-259237-aty0vrat	88	10	(	(	-LRB-
cord-259237-aty0vrat	88	11	100	100	CD
cord-259237-aty0vrat	88	12	mg	mg	NNP
cord-259237-aty0vrat	88	13	/	/	SYM
cord-259237-aty0vrat	88	14	mL	mL	NNP
cord-259237-aty0vrat	88	15	)	)	-RRB-
cord-259237-aty0vrat	88	16	,	,	,
cord-259237-aty0vrat	88	17	which	which	WDT
cord-259237-aty0vrat	88	18	renders	render	VBZ
cord-259237-aty0vrat	88	19	this	this	DT
cord-259237-aty0vrat	88	20	organelle	organelle	NN
cord-259237-aty0vrat	88	21	very	very	RB
cord-259237-aty0vrat	88	22	susceptible	susceptible	JJ
cord-259237-aty0vrat	88	23	to	to	IN
cord-259237-aty0vrat	88	24	protein	protein	NN
cord-259237-aty0vrat	88	25	aggregation	aggregation	NN
cord-259237-aty0vrat	88	26	[	[	-LRB-
cord-259237-aty0vrat	88	27	27	27	CD
cord-259237-aty0vrat	88	28	]	]	-RRB-
cord-259237-aty0vrat	88	29	.	.	.
cord-259237-aty0vrat	89	1	In	in	IN
cord-259237-aty0vrat	89	2	addition	addition	NN
cord-259237-aty0vrat	89	3	,	,	,
cord-259237-aty0vrat	89	4	the	the	DT
cord-259237-aty0vrat	89	5	protein	protein	NN
cord-259237-aty0vrat	89	6	folding	folding	NN
cord-259237-aty0vrat	89	7	is	be	VBZ
cord-259237-aty0vrat	89	8	error	error	NN
cord-259237-aty0vrat	89	9	prone	prone	JJ
cord-259237-aty0vrat	89	10	,	,	,
cord-259237-aty0vrat	89	11	and	and	CC
cord-259237-aty0vrat	89	12	this	this	DT
cord-259237-aty0vrat	89	13	process	process	NN
cord-259237-aty0vrat	89	14	can	can	MD
cord-259237-aty0vrat	89	15	be	be	VB
cord-259237-aty0vrat	89	16	further	further	RB
cord-259237-aty0vrat	89	17	compromised	compromise	VBN
cord-259237-aty0vrat	89	18	by	by	IN
cord-259237-aty0vrat	89	19	physiological	physiological	JJ
cord-259237-aty0vrat	89	20	and	and	CC
cord-259237-aty0vrat	89	21	pathological	pathological	JJ
cord-259237-aty0vrat	89	22	perturbations	perturbation	NNS
cord-259237-aty0vrat	89	23	.	.	.
cord-259237-aty0vrat	90	1	Moreover	moreover	RB
cord-259237-aty0vrat	90	2	,	,	,
cord-259237-aty0vrat	90	3	genetic	genetic	JJ
cord-259237-aty0vrat	90	4	mutations	mutation	NNS
cord-259237-aty0vrat	90	5	may	may	MD
cord-259237-aty0vrat	90	6	prohibit	prohibit	VB
cord-259237-aty0vrat	90	7	proteins	protein	NNS
cord-259237-aty0vrat	90	8	from	from	IN
cord-259237-aty0vrat	90	9	being	be	VBG
cord-259237-aty0vrat	90	10	folded	fold	VBN
cord-259237-aty0vrat	90	11	properly	properly	RB
cord-259237-aty0vrat	90	12	.	.	.
cord-259237-aty0vrat	91	1	All	all	PDT
cord-259237-aty0vrat	91	2	these	these	DT
cord-259237-aty0vrat	91	3	factors	factor	NNS
cord-259237-aty0vrat	91	4	may	may	MD
cord-259237-aty0vrat	91	5	cause	cause	VB
cord-259237-aty0vrat	91	6	the	the	DT
cord-259237-aty0vrat	91	7	accumulation	accumulation	NN
cord-259237-aty0vrat	91	8	of	of	IN
cord-259237-aty0vrat	91	9	unfolded	unfolded	JJ
cord-259237-aty0vrat	91	10	or	or	CC
cord-259237-aty0vrat	91	11	misfolded	misfolde	VBN
cord-259237-aty0vrat	91	12	proteins	protein	NNS
cord-259237-aty0vrat	91	13	.	.	.
cord-259237-aty0vrat	92	1	When	when	WRB
cord-259237-aty0vrat	92	2	the	the	DT
cord-259237-aty0vrat	92	3	level	level	NN
cord-259237-aty0vrat	92	4	of	of	IN
cord-259237-aty0vrat	92	5	these	these	DT
cord-259237-aty0vrat	92	6	aberrant	aberrant	JJ
cord-259237-aty0vrat	92	7	proteins	protein	NNS
cord-259237-aty0vrat	92	8	exceeds	exceed	VBZ
cord-259237-aty0vrat	92	9	the	the	DT
cord-259237-aty0vrat	92	10	folding	folding	NN
cord-259237-aty0vrat	92	11	and	and	CC
cord-259237-aty0vrat	92	12	clearance	clearance	NN
cord-259237-aty0vrat	92	13	capacity	capacity	NN
cord-259237-aty0vrat	92	14	of	of	IN
cord-259237-aty0vrat	92	15	the	the	DT
cord-259237-aty0vrat	92	16	ER	ER	NNP
cord-259237-aty0vrat	92	17	,	,	,
cord-259237-aty0vrat	92	18	known	know	VBN
cord-259237-aty0vrat	92	19	as	as	IN
cord-259237-aty0vrat	92	20	ER	ER	NNP
cord-259237-aty0vrat	92	21	homeostasis	homeostasis	NN
cord-259237-aty0vrat	92	22	,	,	,
cord-259237-aty0vrat	92	23	it	-PRON-	PRP
cord-259237-aty0vrat	92	24	leads	lead	VBZ
cord-259237-aty0vrat	92	25	to	to	IN
cord-259237-aty0vrat	92	26	a	a	DT
cord-259237-aty0vrat	92	27	cellular	cellular	JJ
cord-259237-aty0vrat	92	28	stress	stress	NN
cord-259237-aty0vrat	92	29	response	response	NN
cord-259237-aty0vrat	92	30	termed	term	VBN
cord-259237-aty0vrat	92	31	"	"	``
cord-259237-aty0vrat	92	32	ER	ER	NNP
cord-259237-aty0vrat	92	33	stress	stress	NN
cord-259237-aty0vrat	92	34	"	"	''
cord-259237-aty0vrat	92	35	,	,	,
cord-259237-aty0vrat	92	36	which	which	WDT
cord-259237-aty0vrat	92	37	in	in	IN
cord-259237-aty0vrat	92	38	turn	turn	NN
cord-259237-aty0vrat	92	39	activates	activate	VBZ
cord-259237-aty0vrat	92	40	the	the	DT
cord-259237-aty0vrat	92	41	unfolded	unfolded	JJ
cord-259237-aty0vrat	92	42	protein	protein	NN
cord-259237-aty0vrat	92	43	response	response	NN
cord-259237-aty0vrat	92	44	(	(	-LRB-
cord-259237-aty0vrat	92	45	UPR	UPR	NNP
cord-259237-aty0vrat	92	46	)	)	-RRB-
cord-259237-aty0vrat	92	47	to	to	TO
cord-259237-aty0vrat	92	48	restore	restore	VB
cord-259237-aty0vrat	92	49	the	the	DT
cord-259237-aty0vrat	92	50	ER	ER	NNP
cord-259237-aty0vrat	92	51	homeostasis	homeostasis	NN
cord-259237-aty0vrat	92	52	[	[	-LRB-
cord-259237-aty0vrat	92	53	28	28	CD
cord-259237-aty0vrat	92	54	]	]	-RRB-
cord-259237-aty0vrat	92	55	.	.	.
cord-259237-aty0vrat	93	1	ER	ER	NNP
cord-259237-aty0vrat	93	2	stress	stress	NN
cord-259237-aty0vrat	93	3	is	be	VBZ
cord-259237-aty0vrat	93	4	sensed	sense	VBN
cord-259237-aty0vrat	93	5	by	by	IN
cord-259237-aty0vrat	93	6	three	three	CD
cord-259237-aty0vrat	93	7	ER	ER	NNP
cord-259237-aty0vrat	93	8	transmembrane	transmembrane	NN
cord-259237-aty0vrat	93	9	receptors	receptor	NNS
cord-259237-aty0vrat	93	10	:	:	:
cord-259237-aty0vrat	93	11	double	double	RB
cord-259237-aty0vrat	93	12	-	-	HYPH
cord-259237-aty0vrat	93	13	stranded	strand	VBN
cord-259237-aty0vrat	93	14	RNA	RNA	NNP
cord-259237-aty0vrat	93	15	(	(	-LRB-
cord-259237-aty0vrat	93	16	dsRNA)-activated	dsRNA)-activated	NNP
cord-259237-aty0vrat	93	17	protein	protein	NN
cord-259237-aty0vrat	93	18	kinase	kinase	NN
cord-259237-aty0vrat	93	19	(	(	-LRB-
cord-259237-aty0vrat	93	20	PKR)-like	pkr)-like	JJ
cord-259237-aty0vrat	93	21	ER	ER	NNP
cord-259237-aty0vrat	93	22	kinase	kinase	NN
cord-259237-aty0vrat	93	23	(	(	-LRB-
cord-259237-aty0vrat	93	24	PERK	perk	NN
cord-259237-aty0vrat	93	25	)	)	-RRB-
cord-259237-aty0vrat	93	26	,	,	,
cord-259237-aty0vrat	93	27	inositol	inositol	NN
cord-259237-aty0vrat	93	28	-	-	HYPH
cord-259237-aty0vrat	93	29	requiring	require	VBG
cord-259237-aty0vrat	93	30	enzyme	enzyme	NN
cord-259237-aty0vrat	93	31	1	1	CD
cord-259237-aty0vrat	93	32	(	(	-LRB-
cord-259237-aty0vrat	93	33	IRE1	IRE1	NNP
cord-259237-aty0vrat	93	34	)	)	-RRB-
cord-259237-aty0vrat	93	35	,	,	,
cord-259237-aty0vrat	93	36	and	and	CC
cord-259237-aty0vrat	93	37	activating	activate	VBG
cord-259237-aty0vrat	93	38	transcription	transcription	NN
cord-259237-aty0vrat	93	39	factor	factor	NN
cord-259237-aty0vrat	93	40	6	6	CD
cord-259237-aty0vrat	93	41	(	(	-LRB-
cord-259237-aty0vrat	93	42	ATF6	ATF6	NNP
cord-259237-aty0vrat	93	43	)	)	-RRB-
cord-259237-aty0vrat	93	44	.	.	.
cord-259237-aty0vrat	94	1	PERK	PERK	NNP
cord-259237-aty0vrat	94	2	and	and	CC
cord-259237-aty0vrat	94	3	ATF6	ATF6	NNP
cord-259237-aty0vrat	94	4	are	be	VBP
cord-259237-aty0vrat	94	5	in	in	IN
cord-259237-aty0vrat	94	6	association	association	NN
cord-259237-aty0vrat	94	7	with	with	IN
cord-259237-aty0vrat	94	8	another	another	DT
cord-259237-aty0vrat	94	9	ER	ER	NNP
cord-259237-aty0vrat	94	10	chaperone	chaperone	NN
cord-259237-aty0vrat	94	11	,	,	,
cord-259237-aty0vrat	94	12	the	the	DT
cord-259237-aty0vrat	94	13	binding	bind	VBG
cord-259237-aty0vrat	94	14	immunoglobulin	immunoglobulin	NN
cord-259237-aty0vrat	94	15	protein	protein	NN
cord-259237-aty0vrat	94	16	(	(	-LRB-
cord-259237-aty0vrat	94	17	BiP	BiP	NNP
cord-259237-aty0vrat	94	18	,	,	,
cord-259237-aty0vrat	94	19	or	or	CC
cord-259237-aty0vrat	94	20	GRP78	GRP78	NNP
cord-259237-aty0vrat	94	21	)	)	-RRB-
cord-259237-aty0vrat	94	22	,	,	,
cord-259237-aty0vrat	94	23	when	when	WRB
cord-259237-aty0vrat	94	24	the	the	DT
cord-259237-aty0vrat	94	25	cell	cell	NN
cord-259237-aty0vrat	94	26	is	be	VBZ
cord-259237-aty0vrat	94	27	not	not	RB
cord-259237-aty0vrat	94	28	under	under	IN
cord-259237-aty0vrat	94	29	stress	stress	NN
cord-259237-aty0vrat	94	30	.	.	.
cord-259237-aty0vrat	95	1	BiP	BiP	NNP
cord-259237-aty0vrat	95	2	preferentially	preferentially	RB
cord-259237-aty0vrat	95	3	binds	bind	VBZ
cord-259237-aty0vrat	95	4	to	to	IN
cord-259237-aty0vrat	95	5	misfolded	misfolde	VBN
cord-259237-aty0vrat	95	6	proteins	protein	NNS
cord-259237-aty0vrat	95	7	and	and	CC
cord-259237-aty0vrat	95	8	dissociates	dissociate	VBZ
cord-259237-aty0vrat	95	9	from	from	IN
cord-259237-aty0vrat	95	10	PERK	PERK	NNP
cord-259237-aty0vrat	95	11	and	and	CC
cord-259237-aty0vrat	95	12	ATF6	ATF6	NNP
cord-259237-aty0vrat	95	13	under	under	IN
cord-259237-aty0vrat	95	14	ER	ER	NNP
cord-259237-aty0vrat	95	15	stress	stress	NN
cord-259237-aty0vrat	95	16	,	,	,
cord-259237-aty0vrat	95	17	resulting	result	VBG
cord-259237-aty0vrat	95	18	in	in	IN
cord-259237-aty0vrat	95	19	their	-PRON-	PRP$
cord-259237-aty0vrat	95	20	activation	activation	NN
cord-259237-aty0vrat	95	21	and	and	CC
cord-259237-aty0vrat	95	22	UPR	UPR	NNP
cord-259237-aty0vrat	95	23	to	to	TO
cord-259237-aty0vrat	95	24	mitigate	mitigate	VB
cord-259237-aty0vrat	95	25	this	this	DT
cord-259237-aty0vrat	95	26	stress	stress	NN
cord-259237-aty0vrat	95	27	[	[	-LRB-
cord-259237-aty0vrat	95	28	29	29	CD
cord-259237-aty0vrat	95	29	,	,	,
cord-259237-aty0vrat	95	30	30	30	CD
cord-259237-aty0vrat	95	31	]	]	-RRB-
cord-259237-aty0vrat	95	32	.	.	.
cord-259237-aty0vrat	96	1	IRE1	IRE1	NNP
cord-259237-aty0vrat	96	2	is	be	VBZ
cord-259237-aty0vrat	96	3	activated	activate	VBN
cord-259237-aty0vrat	96	4	by	by	IN
cord-259237-aty0vrat	96	5	the	the	DT
cord-259237-aty0vrat	96	6	direct	direct	JJ
cord-259237-aty0vrat	96	7	binding	binding	NN
cord-259237-aty0vrat	96	8	of	of	IN
cord-259237-aty0vrat	96	9	unfolded	unfolded	JJ
cord-259237-aty0vrat	96	10	proteins	protein	NNS
cord-259237-aty0vrat	96	11	[	[	-LRB-
cord-259237-aty0vrat	96	12	31	31	CD
cord-259237-aty0vrat	96	13	]	]	-RRB-
cord-259237-aty0vrat	96	14	.	.	.
cord-259237-aty0vrat	97	1	IRE1	IRE1	NNP
cord-259237-aty0vrat	97	2	then	then	RB
cord-259237-aty0vrat	97	3	activates	activate	VBZ
cord-259237-aty0vrat	97	4	the	the	DT
cord-259237-aty0vrat	97	5	transcription	transcription	NN
cord-259237-aty0vrat	97	6	factor	factor	NN
cord-259237-aty0vrat	97	7	X	X	NNP
cord-259237-aty0vrat	97	8	-	-	NNP
cord-259237-aty0vrat	97	9	Box	Box	NNP
cord-259237-aty0vrat	97	10	Binding	Binding	NNP
cord-259237-aty0vrat	97	11	Protein	Protein	NNP
cord-259237-aty0vrat	97	12	1	1	CD
cord-259237-aty0vrat	97	13	(	(	-LRB-
cord-259237-aty0vrat	97	14	XBP-1	XBP-1	NNP
cord-259237-aty0vrat	97	15	)	)	-RRB-
cord-259237-aty0vrat	97	16	,	,	,
cord-259237-aty0vrat	97	17	which	which	WDT
cord-259237-aty0vrat	97	18	in	in	IN
cord-259237-aty0vrat	97	19	turn	turn	NN
cord-259237-aty0vrat	97	20	up	up	RP
cord-259237-aty0vrat	97	21	-	-	HYPH
cord-259237-aty0vrat	97	22	regulates	regulate	NNS
cord-259237-aty0vrat	97	23	ER	ER	NNP
cord-259237-aty0vrat	97	24	chaperones	chaperone	NNS
cord-259237-aty0vrat	97	25	to	to	TO
cord-259237-aty0vrat	97	26	assist	assist	VB
cord-259237-aty0vrat	97	27	in	in	IN
cord-259237-aty0vrat	97	28	the	the	DT
cord-259237-aty0vrat	97	29	folding	folding	NN
cord-259237-aty0vrat	97	30	capacity	capacity	NN
cord-259237-aty0vrat	97	31	of	of	IN
cord-259237-aty0vrat	97	32	the	the	DT
cord-259237-aty0vrat	97	33	ER	ER	NNP
cord-259237-aty0vrat	97	34	as	as	RB
cord-259237-aty0vrat	97	35	well	well	RB
cord-259237-aty0vrat	97	36	as	as	IN
cord-259237-aty0vrat	97	37	ERAD	ERAD	NNP
cord-259237-aty0vrat	97	38	components	component	NNS
cord-259237-aty0vrat	97	39	to	to	TO
cord-259237-aty0vrat	97	40	boost	boost	VB
cord-259237-aty0vrat	97	41	protein	protein	NN
cord-259237-aty0vrat	97	42	degradation	degradation	NN
cord-259237-aty0vrat	97	43	.	.	.
cord-259237-aty0vrat	98	1	PERK	PERK	NNP
cord-259237-aty0vrat	98	2	phosphorylates	phosphorylate	VBZ
cord-259237-aty0vrat	98	3	the	the	DT
cord-259237-aty0vrat	98	4	eukaryotic	eukaryotic	JJ
cord-259237-aty0vrat	98	5	initiation	initiation	NN
cord-259237-aty0vrat	98	6	factor	factor	NN
cord-259237-aty0vrat	98	7	(	(	-LRB-
cord-259237-aty0vrat	98	8	eIF)-2α	eIF)-2α	NNP
cord-259237-aty0vrat	98	9	and	and	CC
cord-259237-aty0vrat	98	10	halts	halt	VBZ
cord-259237-aty0vrat	98	11	protein	protein	NN
cord-259237-aty0vrat	98	12	translation	translation	NN
cord-259237-aty0vrat	98	13	,	,	,
cord-259237-aty0vrat	98	14	and	and	CC
cord-259237-aty0vrat	98	15	ATF6	ATF6	NNP
cord-259237-aty0vrat	98	16	up	up	RB
cord-259237-aty0vrat	98	17	-	-	HYPH
cord-259237-aty0vrat	98	18	regulates	regulate	VBZ
cord-259237-aty0vrat	98	19	protein	protein	NN
cord-259237-aty0vrat	98	20	expression	expression	NN
cord-259237-aty0vrat	98	21	to	to	TO
cord-259237-aty0vrat	98	22	boost	boost	VB
cord-259237-aty0vrat	98	23	the	the	DT
cord-259237-aty0vrat	98	24	ER	ER	NNP
cord-259237-aty0vrat	98	25	protein	protein	NN
cord-259237-aty0vrat	98	26	folding	folding	NN
cord-259237-aty0vrat	98	27	capacity	capacity	NN
cord-259237-aty0vrat	98	28	and	and	CC
cord-259237-aty0vrat	98	29	ERAD	ERAD	NNP
cord-259237-aty0vrat	98	30	.	.	.
cord-259237-aty0vrat	99	1	However	however	RB
cord-259237-aty0vrat	99	2	,	,	,
cord-259237-aty0vrat	99	3	if	if	IN
cord-259237-aty0vrat	99	4	these	these	DT
cord-259237-aty0vrat	99	5	objectives	objective	NNS
cord-259237-aty0vrat	99	6	are	be	VBP
cord-259237-aty0vrat	99	7	not	not	RB
cord-259237-aty0vrat	99	8	achieved	achieve	VBN
cord-259237-aty0vrat	99	9	within	within	IN
cord-259237-aty0vrat	99	10	a	a	DT
cord-259237-aty0vrat	99	11	certain	certain	JJ
cord-259237-aty0vrat	99	12	time	time	NN
cord-259237-aty0vrat	99	13	span	span	NN
cord-259237-aty0vrat	99	14	or	or	CC
cord-259237-aty0vrat	99	15	if	if	IN
cord-259237-aty0vrat	99	16	the	the	DT
cord-259237-aty0vrat	99	17	disruption	disruption	NN
cord-259237-aty0vrat	99	18	is	be	VBZ
cord-259237-aty0vrat	99	19	prolonged	prolong	VBN
cord-259237-aty0vrat	99	20	,	,	,
cord-259237-aty0vrat	99	21	UPR	UPR	NNP
cord-259237-aty0vrat	99	22	also	also	RB
cord-259237-aty0vrat	99	23	activates	activate	VBZ
cord-259237-aty0vrat	99	24	pathways	pathway	NNS
cord-259237-aty0vrat	99	25	leading	lead	VBG
cord-259237-aty0vrat	99	26	to	to	IN
cord-259237-aty0vrat	99	27	cell	cell	NN
cord-259237-aty0vrat	99	28	death	death	NN
cord-259237-aty0vrat	99	29	.	.	.
cord-259237-aty0vrat	100	1	Although	although	IN
cord-259237-aty0vrat	100	2	PERK	PERK	NNP
cord-259237-aty0vrat	100	3	activation	activation	NN
cord-259237-aty0vrat	100	4	causes	cause	VBZ
cord-259237-aty0vrat	100	5	global	global	JJ
cord-259237-aty0vrat	100	6	inhibition	inhibition	NN
cord-259237-aty0vrat	100	7	of	of	IN
cord-259237-aty0vrat	100	8	protein	protein	NN
cord-259237-aty0vrat	100	9	translation	translation	NN
cord-259237-aty0vrat	100	10	by	by	IN
cord-259237-aty0vrat	100	11	blocking	block	VBG
cord-259237-aty0vrat	100	12	eIF-2α	eif-2α	JJ
cord-259237-aty0vrat	100	13	activity	activity	NN
cord-259237-aty0vrat	100	14	,	,	,
cord-259237-aty0vrat	100	15	it	-PRON-	PRP
cord-259237-aty0vrat	100	16	paradoxically	paradoxically	RB
cord-259237-aty0vrat	100	17	enhances	enhance	VBZ
cord-259237-aty0vrat	100	18	translation	translation	NN
cord-259237-aty0vrat	100	19	of	of	IN
cord-259237-aty0vrat	100	20	the	the	DT
cord-259237-aty0vrat	100	21	transcription	transcription	NN
cord-259237-aty0vrat	100	22	factor	factor	NN
cord-259237-aty0vrat	100	23	ATF4	ATF4	NNP
cord-259237-aty0vrat	100	24	.	.	.
cord-259237-aty0vrat	101	1	ATF4	ATF4	NNP
cord-259237-aty0vrat	101	2	then	then	RB
cord-259237-aty0vrat	101	3	trans	trans	NNP
cord-259237-aty0vrat	101	4	-	-	VBZ
cord-259237-aty0vrat	101	5	activates	activate	VBZ
cord-259237-aty0vrat	101	6	the	the	DT
cord-259237-aty0vrat	101	7	CCAAT	CCAAT	NNP
cord-259237-aty0vrat	101	8	/	/	SYM
cord-259237-aty0vrat	101	9	enhancer	enhancer	NN
cord-259237-aty0vrat	101	10	-	-	HYPH
cord-259237-aty0vrat	101	11	binding	bind	VBG
cord-259237-aty0vrat	101	12	protein	protein	NN
cord-259237-aty0vrat	101	13	-	-	HYPH
cord-259237-aty0vrat	101	14	homologous	homologous	JJ
cord-259237-aty0vrat	101	15	protein	protein	NN
cord-259237-aty0vrat	101	16	(	(	-LRB-
cord-259237-aty0vrat	101	17	CHOP	CHOP	NNP
cord-259237-aty0vrat	101	18	)	)	-RRB-
cord-259237-aty0vrat	101	19	,	,	,
cord-259237-aty0vrat	101	20	which	which	WDT
cord-259237-aty0vrat	101	21	is	be	VBZ
cord-259237-aty0vrat	101	22	a	a	DT
cord-259237-aty0vrat	101	23	pro	pro	JJ
cord-259237-aty0vrat	101	24	-	-	JJ
cord-259237-aty0vrat	101	25	apoptotic	apoptotic	JJ
cord-259237-aty0vrat	101	26	transcription	transcription	NN
cord-259237-aty0vrat	101	27	factor	factor	NN
cord-259237-aty0vrat	101	28	,	,	,
cord-259237-aty0vrat	101	29	resulting	result	VBG
cord-259237-aty0vrat	101	30	in	in	IN
cord-259237-aty0vrat	101	31	cell	cell	NN
cord-259237-aty0vrat	101	32	death	death	NN
cord-259237-aty0vrat	101	33	by	by	IN
cord-259237-aty0vrat	101	34	apoptosis	apoptosis	NN
cord-259237-aty0vrat	101	35	[	[	-LRB-
cord-259237-aty0vrat	101	36	32	32	CD
cord-259237-aty0vrat	101	37	]	]	-RRB-
cord-259237-aty0vrat	101	38	.	.	.
cord-259237-aty0vrat	102	1	ERAD	ERAD	NNP
cord-259237-aty0vrat	102	2	is	be	VBZ
cord-259237-aty0vrat	102	3	a	a	DT
cord-259237-aty0vrat	102	4	protein	protein	NN
cord-259237-aty0vrat	102	5	quality	quality	NN
cord-259237-aty0vrat	102	6	control	control	NN
cord-259237-aty0vrat	102	7	mechanism	mechanism	NN
cord-259237-aty0vrat	102	8	conserved	conserve	VBN
cord-259237-aty0vrat	102	9	in	in	IN
cord-259237-aty0vrat	102	10	all	all	DT
cord-259237-aty0vrat	102	11	eukaryotic	eukaryotic	JJ
cord-259237-aty0vrat	102	12	cells	cell	NNS
cord-259237-aty0vrat	102	13	,	,	,
cord-259237-aty0vrat	102	14	which	which	WDT
cord-259237-aty0vrat	102	15	is	be	VBZ
cord-259237-aty0vrat	102	16	an	an	DT
cord-259237-aty0vrat	102	17	important	important	JJ
cord-259237-aty0vrat	102	18	arm	arm	NN
cord-259237-aty0vrat	102	19	of	of	IN
cord-259237-aty0vrat	102	20	UPR	UPR	NNP
cord-259237-aty0vrat	102	21	,	,	,
cord-259237-aty0vrat	102	22	necessary	necessary	JJ
cord-259237-aty0vrat	102	23	to	to	TO
cord-259237-aty0vrat	102	24	alleviate	alleviate	VB
cord-259237-aty0vrat	102	25	ER	ER	NNP
cord-259237-aty0vrat	102	26	stress	stress	NN
cord-259237-aty0vrat	102	27	[	[	-LRB-
cord-259237-aty0vrat	102	28	33	33	CD
cord-259237-aty0vrat	102	29	]	]	-RRB-
cord-259237-aty0vrat	102	30	.	.	.
cord-259237-aty0vrat	103	1	ERAD	ERAD	NNP
cord-259237-aty0vrat	103	2	results	result	NNS
cord-259237-aty0vrat	103	3	in	in	IN
cord-259237-aty0vrat	103	4	the	the	DT
cord-259237-aty0vrat	103	5	selective	selective	JJ
cord-259237-aty0vrat	103	6	dislocation	dislocation	NN
cord-259237-aty0vrat	103	7	of	of	IN
cord-259237-aty0vrat	103	8	unfolded	unfolded	JJ
cord-259237-aty0vrat	103	9	and	and	CC
cord-259237-aty0vrat	103	10	misfolded	misfolde	VBN
cord-259237-aty0vrat	103	11	proteins	protein	NNS
cord-259237-aty0vrat	103	12	from	from	IN
cord-259237-aty0vrat	103	13	the	the	DT
cord-259237-aty0vrat	103	14	ER	ER	NNP
cord-259237-aty0vrat	103	15	to	to	IN
cord-259237-aty0vrat	103	16	the	the	DT
cord-259237-aty0vrat	103	17	cytosol	cytosol	NN
cord-259237-aty0vrat	103	18	via	via	IN
cord-259237-aty0vrat	103	19	specific	specific	JJ
cord-259237-aty0vrat	103	20	membrane	membrane	NN
cord-259237-aty0vrat	103	21	machinery	machinery	NN
cord-259237-aty0vrat	103	22	.	.	.
cord-259237-aty0vrat	104	1	ERAD	ERAD	NNP
cord-259237-aty0vrat	104	2	targets	target	NNS
cord-259237-aty0vrat	104	3	are	be	VBP
cord-259237-aty0vrat	104	4	subsequently	subsequently	RB
cord-259237-aty0vrat	104	5	degraded	degrade	VBN
cord-259237-aty0vrat	104	6	by	by	IN
cord-259237-aty0vrat	104	7	the	the	DT
cord-259237-aty0vrat	104	8	cytosolic	cytosolic	JJ
cord-259237-aty0vrat	104	9	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	104	10	proteasome	proteasome	NN
cord-259237-aty0vrat	104	11	system	system	NN
cord-259237-aty0vrat	104	12	(	(	-LRB-
cord-259237-aty0vrat	104	13	UPS	UPS	NNP
cord-259237-aty0vrat	104	14	)	)	-RRB-
cord-259237-aty0vrat	104	15	[	[	-LRB-
cord-259237-aty0vrat	104	16	34	34	CD
cord-259237-aty0vrat	104	17	]	]	-RRB-
cord-259237-aty0vrat	104	18	.	.	.
cord-259237-aty0vrat	105	1	Quality	quality	NN
cord-259237-aty0vrat	105	2	control	control	NN
cord-259237-aty0vrat	105	3	of	of	IN
cord-259237-aty0vrat	105	4	functional	functional	JJ
cord-259237-aty0vrat	105	5	proteins	protein	NNS
cord-259237-aty0vrat	105	6	produced	produce	VBN
cord-259237-aty0vrat	105	7	from	from	IN
cord-259237-aty0vrat	105	8	the	the	DT
cord-259237-aty0vrat	105	9	ER	ER	NNP
cord-259237-aty0vrat	105	10	is	be	VBZ
cord-259237-aty0vrat	105	11	also	also	RB
cord-259237-aty0vrat	105	12	critical	critical	JJ
cord-259237-aty0vrat	105	13	for	for	IN
cord-259237-aty0vrat	105	14	maintenance	maintenance	NN
cord-259237-aty0vrat	105	15	of	of	IN
cord-259237-aty0vrat	105	16	the	the	DT
cord-259237-aty0vrat	105	17	ER	ER	NNP
cord-259237-aty0vrat	105	18	homeostasis	homeostasis	NN
cord-259237-aty0vrat	105	19	by	by	IN
cord-259237-aty0vrat	105	20	eliminating	eliminate	VBG
cord-259237-aty0vrat	105	21	unfolded	unfold	VBN
cord-259237-aty0vrat	105	22	and	and	CC
cord-259237-aty0vrat	105	23	misfolded	misfolde	VBN
cord-259237-aty0vrat	105	24	proteins	protein	NNS
cord-259237-aty0vrat	105	25	.	.	.
cord-259237-aty0vrat	106	1	Thus	thus	RB
cord-259237-aty0vrat	106	2	,	,	,
cord-259237-aty0vrat	106	3	ERAD	ERAD	NNP
cord-259237-aty0vrat	106	4	is	be	VBZ
cord-259237-aty0vrat	106	5	a	a	DT
cord-259237-aty0vrat	106	6	central	central	JJ
cord-259237-aty0vrat	106	7	element	element	NN
cord-259237-aty0vrat	106	8	of	of	IN
cord-259237-aty0vrat	106	9	both	both	CC
cord-259237-aty0vrat	106	10	the	the	DT
cord-259237-aty0vrat	106	11	secretory	secretory	JJ
cord-259237-aty0vrat	106	12	pathway	pathway	NN
cord-259237-aty0vrat	106	13	and	and	CC
cord-259237-aty0vrat	106	14	UPR	UPR	NNP
cord-259237-aty0vrat	106	15	,	,	,
cord-259237-aty0vrat	106	16	which	which	WDT
cord-259237-aty0vrat	106	17	targets	target	VBZ
cord-259237-aty0vrat	106	18	a	a	DT
cord-259237-aty0vrat	106	19	number	number	NN
cord-259237-aty0vrat	106	20	of	of	IN
cord-259237-aty0vrat	106	21	physiological	physiological	JJ
cord-259237-aty0vrat	106	22	and	and	CC
cord-259237-aty0vrat	106	23	pathological	pathological	JJ
cord-259237-aty0vrat	106	24	substrates	substrate	NNS
cord-259237-aty0vrat	106	25	such	such	JJ
cord-259237-aty0vrat	106	26	as	as	IN
cord-259237-aty0vrat	106	27	the	the	DT
cord-259237-aty0vrat	106	28	T	T	NNP
cord-259237-aty0vrat	106	29	cell	cell	NN
cord-259237-aty0vrat	106	30	antigen	antigen	NN
cord-259237-aty0vrat	106	31	receptor	receptor	NN
cord-259237-aty0vrat	106	32	(	(	-LRB-
cord-259237-aty0vrat	106	33	TCR	TCR	NNP
cord-259237-aty0vrat	106	34	)	)	-RRB-
cord-259237-aty0vrat	106	35	[	[	-LRB-
cord-259237-aty0vrat	106	36	35	35	CD
cord-259237-aty0vrat	106	37	]	]	-RRB-
cord-259237-aty0vrat	106	38	,	,	,
cord-259237-aty0vrat	106	39	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-259237-aty0vrat	106	40	coenzyme	coenzyme	NN
cord-259237-aty0vrat	106	41	-	-	HYPH
cord-259237-aty0vrat	106	42	A	a	NN
cord-259237-aty0vrat	106	43	(	(	-LRB-
cord-259237-aty0vrat	106	44	HMG	HMG	NNP
cord-259237-aty0vrat	106	45	-	-	HYPH
cord-259237-aty0vrat	106	46	CoA	CoA	NNP
cord-259237-aty0vrat	106	47	)	)	-RRB-
cord-259237-aty0vrat	107	1	reductase	reductase	NN
cord-259237-aty0vrat	107	2	(	(	-LRB-
cord-259237-aty0vrat	107	3	HMGCR	HMGCR	NNP
cord-259237-aty0vrat	107	4	)	)	-RRB-
cord-259237-aty0vrat	108	1	[	[	-LRB-
cord-259237-aty0vrat	108	2	35	35	CD
cord-259237-aty0vrat	108	3	]	]	-RRB-
cord-259237-aty0vrat	108	4	,	,	,
cord-259237-aty0vrat	108	5	squalene	squalene	NN
cord-259237-aty0vrat	108	6	monooxygenase	monooxygenase	NN
cord-259237-aty0vrat	108	7	(	(	-LRB-
cord-259237-aty0vrat	108	8	SQLE	SQLE	NNP
cord-259237-aty0vrat	108	9	)	)	-RRB-
cord-259237-aty0vrat	108	10	[	[	-LRB-
cord-259237-aty0vrat	108	11	36	36	CD
cord-259237-aty0vrat	108	12	]	]	-RRB-
cord-259237-aty0vrat	108	13	,	,	,
cord-259237-aty0vrat	108	14	Inositol	Inositol	NNP
cord-259237-aty0vrat	108	15	1,4,5-trisphosphate	1,4,5-trisphosphate	CD
cord-259237-aty0vrat	108	16	(	(	-LRB-
cord-259237-aty0vrat	108	17	IP	IP	NNP
cord-259237-aty0vrat	108	18	3	3	CD
cord-259237-aty0vrat	108	19	)	)	-RRB-
cord-259237-aty0vrat	108	20	receptor	receptor	NN
cord-259237-aty0vrat	108	21	[	[	-LRB-
cord-259237-aty0vrat	108	22	37	37	CD
cord-259237-aty0vrat	108	23	]	]	-RRB-
cord-259237-aty0vrat	108	24	,	,	,
cord-259237-aty0vrat	108	25	diacylglycerol	diacylglycerol	NN
cord-259237-aty0vrat	108	26	acyltransferase	acyltransferase	NNP
cord-259237-aty0vrat	108	27	2	2	CD
cord-259237-aty0vrat	108	28	(	(	-LRB-
cord-259237-aty0vrat	108	29	DGAT2	DGAT2	NNP
cord-259237-aty0vrat	108	30	)	)	-RRB-
cord-259237-aty0vrat	108	31	[	[	-LRB-
cord-259237-aty0vrat	108	32	38	38	CD
cord-259237-aty0vrat	108	33	]	]	-RRB-
cord-259237-aty0vrat	108	34	,	,	,
cord-259237-aty0vrat	108	35	heme	heme	JJ
cord-259237-aty0vrat	108	36	oxygenase-1	oxygenase-1	NNP
cord-259237-aty0vrat	108	37	(	(	-LRB-
cord-259237-aty0vrat	108	38	HO-1	HO-1	NNP
cord-259237-aty0vrat	108	39	)	)	-RRB-
cord-259237-aty0vrat	109	1	[	[	-LRB-
cord-259237-aty0vrat	109	2	39	39	CD
cord-259237-aty0vrat	109	3	]	]	-RRB-
cord-259237-aty0vrat	109	4	,	,	,
cord-259237-aty0vrat	109	5	alpha-1	alpha-1	NN
cord-259237-aty0vrat	109	6	antitrypsin	antitrypsin	NN
cord-259237-aty0vrat	109	7	[	[	-LRB-
cord-259237-aty0vrat	109	8	35	35	CD
cord-259237-aty0vrat	109	9	]	]	-RRB-
cord-259237-aty0vrat	109	10	,	,	,
cord-259237-aty0vrat	109	11	and	and	CC
cord-259237-aty0vrat	109	12	cystic	cystic	JJ
cord-259237-aty0vrat	109	13	fibrosis	fibrosis	NN
cord-259237-aty0vrat	109	14	transmembrane	transmembrane	NNP
cord-259237-aty0vrat	109	15	regulator	regulator	NN
cord-259237-aty0vrat	109	16	(	(	-LRB-
cord-259237-aty0vrat	109	17	CFTR	CFTR	NNP
cord-259237-aty0vrat	109	18	)	)	-RRB-
cord-259237-aty0vrat	109	19	[	[	-LRB-
cord-259237-aty0vrat	109	20	40	40	CD
cord-259237-aty0vrat	109	21	]	]	-RRB-
cord-259237-aty0vrat	109	22	.	.	.
cord-259237-aty0vrat	110	1	So	so	RB
cord-259237-aty0vrat	110	2	far	far	RB
cord-259237-aty0vrat	110	3	,	,	,
cord-259237-aty0vrat	110	4	more	more	JJR
cord-259237-aty0vrat	110	5	than	than	IN
cord-259237-aty0vrat	110	6	60	60	CD
cord-259237-aty0vrat	110	7	human	human	JJ
cord-259237-aty0vrat	110	8	diseases	disease	NNS
cord-259237-aty0vrat	110	9	have	have	VBP
cord-259237-aty0vrat	110	10	been	be	VBN
cord-259237-aty0vrat	110	11	attributed	attribute	VBN
cord-259237-aty0vrat	110	12	to	to	IN
cord-259237-aty0vrat	110	13	this	this	DT
cord-259237-aty0vrat	110	14	pathway	pathway	NN
cord-259237-aty0vrat	110	15	[	[	-LRB-
cord-259237-aty0vrat	110	16	41	41	CD
cord-259237-aty0vrat	110	17	]	]	-RRB-
cord-259237-aty0vrat	110	18	.	.	.
cord-259237-aty0vrat	111	1	Although	although	IN
cord-259237-aty0vrat	111	2	the	the	DT
cord-259237-aty0vrat	111	3	vast	vast	JJ
cord-259237-aty0vrat	111	4	majority	majority	NN
cord-259237-aty0vrat	111	5	of	of	IN
cord-259237-aty0vrat	111	6	secreted	secrete	VBN
cord-259237-aty0vrat	111	7	proteins	protein	NNS
cord-259237-aty0vrat	111	8	are	be	VBP
cord-259237-aty0vrat	111	9	glycosylated	glycosylate	VBN
cord-259237-aty0vrat	111	10	,	,	,
cord-259237-aty0vrat	111	11	the	the	DT
cord-259237-aty0vrat	111	12	ER	ER	NNP
cord-259237-aty0vrat	111	13	is	be	VBZ
cord-259237-aty0vrat	111	14	responsible	responsible	JJ
cord-259237-aty0vrat	111	15	for	for	IN
cord-259237-aty0vrat	111	16	the	the	DT
cord-259237-aty0vrat	111	17	folding	folding	NN
cord-259237-aty0vrat	111	18	and	and	CC
cord-259237-aty0vrat	111	19	assembly	assembly	NN
cord-259237-aty0vrat	111	20	of	of	IN
cord-259237-aty0vrat	111	21	both	both	CC
cord-259237-aty0vrat	111	22	glycosylated	glycosylated	JJ
cord-259237-aty0vrat	111	23	and	and	CC
cord-259237-aty0vrat	111	24	non	non	JJ
cord-259237-aty0vrat	111	25	-	-	JJ
cord-259237-aty0vrat	111	26	glycosylated	glycosylated	JJ
cord-259237-aty0vrat	111	27	proteins	protein	NNS
cord-259237-aty0vrat	111	28	into	into	IN
cord-259237-aty0vrat	111	29	functional	functional	JJ
cord-259237-aty0vrat	111	30	complexes	complex	NNS
cord-259237-aty0vrat	111	31	,	,	,
cord-259237-aty0vrat	111	32	which	which	WDT
cord-259237-aty0vrat	111	33	are	be	VBP
cord-259237-aty0vrat	111	34	subjected	subject	VBN
cord-259237-aty0vrat	111	35	to	to	IN
cord-259237-aty0vrat	111	36	ERAD	ERAD	NNP
cord-259237-aty0vrat	111	37	quality	quality	NN
cord-259237-aty0vrat	111	38	control	control	NN
cord-259237-aty0vrat	111	39	if	if	IN
cord-259237-aty0vrat	111	40	they	-PRON-	PRP
cord-259237-aty0vrat	111	41	are	be	VBP
cord-259237-aty0vrat	111	42	misfolded	misfolde	VBN
cord-259237-aty0vrat	111	43	.	.	.
cord-259237-aty0vrat	112	1	The	the	DT
cord-259237-aty0vrat	112	2	process	process	NN
cord-259237-aty0vrat	112	3	of	of	IN
cord-259237-aty0vrat	112	4	ERAD	ERAD	NNP
cord-259237-aty0vrat	112	5	can	can	MD
cord-259237-aty0vrat	112	6	be	be	VB
cord-259237-aty0vrat	112	7	divided	divide	VBN
cord-259237-aty0vrat	112	8	into	into	IN
cord-259237-aty0vrat	112	9	three	three	CD
cord-259237-aty0vrat	112	10	steps	step	NNS
cord-259237-aty0vrat	112	11	:	:	:
cord-259237-aty0vrat	112	12	substrate	substrate	NN
cord-259237-aty0vrat	112	13	recognition	recognition	NN
cord-259237-aty0vrat	112	14	,	,	,
cord-259237-aty0vrat	112	15	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	112	16	,	,	,
cord-259237-aty0vrat	112	17	and	and	CC
cord-259237-aty0vrat	112	18	ubiquitylation	ubiquitylation	NN
cord-259237-aty0vrat	112	19	/	/	SYM
cord-259237-aty0vrat	112	20	proteasomal	proteasomal	JJ
cord-259237-aty0vrat	112	21	degradation	degradation	NN
cord-259237-aty0vrat	112	22	.	.	.
cord-259237-aty0vrat	113	1	In	in	IN
cord-259237-aty0vrat	113	2	fact	fact	NN
cord-259237-aty0vrat	113	3	,	,	,
cord-259237-aty0vrat	113	4	extensive	extensive	JJ
cord-259237-aty0vrat	113	5	excision	excision	NN
cord-259237-aty0vrat	113	6	of	of	IN
cord-259237-aty0vrat	113	7	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	113	8	residues	residue	NNS
cord-259237-aty0vrat	113	9	from	from	IN
cord-259237-aty0vrat	113	10	N	n	NN
cord-259237-aty0vrat	113	11	-	-	HYPH
cord-259237-aty0vrat	113	12	glycans	glycan	NNS
cord-259237-aty0vrat	113	13	sends	send	VBZ
cord-259237-aty0vrat	113	14	an	an	DT
cord-259237-aty0vrat	113	15	important	important	JJ
cord-259237-aty0vrat	113	16	signal	signal	NN
cord-259237-aty0vrat	113	17	to	to	TO
cord-259237-aty0vrat	113	18	trigger	trigger	VB
cord-259237-aty0vrat	113	19	misfolded	misfolde	VBN
cord-259237-aty0vrat	113	20	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	113	21	degradation	degradation	NN
cord-259237-aty0vrat	113	22	,	,	,
cord-259237-aty0vrat	113	23	which	which	WDT
cord-259237-aty0vrat	113	24	is	be	VBZ
cord-259237-aty0vrat	113	25	dependent	dependent	JJ
cord-259237-aty0vrat	113	26	on	on	IN
cord-259237-aty0vrat	113	27	class	class	NN
cord-259237-aty0vrat	114	1	I	-PRON-	PRP
cord-259237-aty0vrat	114	2	mannosidases	mannosidase	NNS
cord-259237-aty0vrat	114	3	[	[	-LRB-
cord-259237-aty0vrat	114	4	42	42	CD
cord-259237-aty0vrat	114	5	]	]	-RRB-
cord-259237-aty0vrat	114	6	.	.	.
cord-259237-aty0vrat	115	1	Class	class	NN
cord-259237-aty0vrat	115	2	I	-PRON-	PRP
cord-259237-aty0vrat	115	3	mannosidases	mannosidase	NNS
cord-259237-aty0vrat	115	4	belong	belong	VBP
cord-259237-aty0vrat	115	5	to	to	IN
cord-259237-aty0vrat	115	6	the	the	DT
cord-259237-aty0vrat	115	7	glycoside	glycoside	NN
cord-259237-aty0vrat	115	8	hydrolase	hydrolase	NN
cord-259237-aty0vrat	115	9	family	family	NN
cord-259237-aty0vrat	115	10	47	47	CD
cord-259237-aty0vrat	116	1	(	(	-LRB-
cord-259237-aty0vrat	116	2	GH47	GH47	NNP
cord-259237-aty0vrat	116	3	)	)	-RRB-
cord-259237-aty0vrat	116	4	,	,	,
cord-259237-aty0vrat	116	5	which	which	WDT
cord-259237-aty0vrat	116	6	are	be	VBP
cord-259237-aty0vrat	116	7	exo	exo	NN
cord-259237-aty0vrat	116	8	-	-	HYPH
cord-259237-aty0vrat	116	9	acting	acting	NNP
cord-259237-aty0vrat	116	10	α1,2-mannosidases	α1,2-mannosidases	XX
cord-259237-aty0vrat	116	11	that	that	WDT
cord-259237-aty0vrat	116	12	are	be	VBP
cord-259237-aty0vrat	116	13	divided	divide	VBN
cord-259237-aty0vrat	116	14	into	into	IN
cord-259237-aty0vrat	116	15	three	three	CD
cord-259237-aty0vrat	116	16	subfamilies	subfamily	NNS
cord-259237-aty0vrat	116	17	[	[	-LRB-
cord-259237-aty0vrat	116	18	43	43	CD
cord-259237-aty0vrat	116	19	]	]	-RRB-
cord-259237-aty0vrat	116	20	.	.	.
cord-259237-aty0vrat	117	1	The	the	DT
cord-259237-aty0vrat	117	2	first	first	JJ
cord-259237-aty0vrat	117	3	subfamily	subfamily	NN
cord-259237-aty0vrat	117	4	consists	consist	VBZ
cord-259237-aty0vrat	117	5	of	of	IN
cord-259237-aty0vrat	117	6	ERManI	ERManI	NNP
cord-259237-aty0vrat	117	7	,	,	,
cord-259237-aty0vrat	117	8	which	which	WDT
cord-259237-aty0vrat	117	9	is	be	VBZ
cord-259237-aty0vrat	117	10	supposed	suppose	VBN
cord-259237-aty0vrat	117	11	to	to	TO
cord-259237-aty0vrat	117	12	cleave	cleave	VB
cord-259237-aty0vrat	117	13	the	the	DT
cord-259237-aty0vrat	117	14	outmost	outmost	JJ
cord-259237-aty0vrat	117	15	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	117	16	residue	residue	NN
cord-259237-aty0vrat	117	17	on	on	IN
cord-259237-aty0vrat	117	18	the	the	DT
cord-259237-aty0vrat	117	19	b	b	NN
cord-259237-aty0vrat	117	20	branch	branch	NN
cord-259237-aty0vrat	117	21	from	from	IN
cord-259237-aty0vrat	117	22	N	n	NN
cord-259237-aty0vrat	117	23	-	-	HYPH
cord-259237-aty0vrat	117	24	linked	link	VBN
cord-259237-aty0vrat	117	25	glycans	glycan	NNS
cord-259237-aty0vrat	117	26	in	in	IN
cord-259237-aty0vrat	117	27	the	the	DT
cord-259237-aty0vrat	117	28	ER	er	NN
cord-259237-aty0vrat	117	29	.	.	.
cord-259237-aty0vrat	118	1	The	the	DT
cord-259237-aty0vrat	118	2	second	second	JJ
cord-259237-aty0vrat	118	3	subfamily	subfamily	NN
cord-259237-aty0vrat	118	4	consists	consist	VBZ
cord-259237-aty0vrat	118	5	of	of	IN
cord-259237-aty0vrat	118	6	three	three	CD
cord-259237-aty0vrat	118	7	Golgi	Golgi	NNP
cord-259237-aty0vrat	118	8	α	α	NN
cord-259237-aty0vrat	118	9	-	-	HYPH
cord-259237-aty0vrat	118	10	mannosidase	mannosidase	NN
cord-259237-aty0vrat	118	11	I	I	NNP
cord-259237-aty0vrat	118	12	,	,	,
cord-259237-aty0vrat	118	13	including	include	VBG
cord-259237-aty0vrat	118	14	GolgiManIA	golgimania	NN
cord-259237-aty0vrat	118	15	,	,	,
cord-259237-aty0vrat	118	16	GolgiManIB	golgimanib	JJ
cord-259237-aty0vrat	118	17	,	,	,
cord-259237-aty0vrat	118	18	and	and	CC
cord-259237-aty0vrat	118	19	GolgiManIC	golgimanic	RB
cord-259237-aty0vrat	118	20	,	,	,
cord-259237-aty0vrat	118	21	which	which	WDT
cord-259237-aty0vrat	118	22	cleave	cleave	VBP
cord-259237-aty0vrat	119	1	the	the	DT
cord-259237-aty0vrat	119	2	remaining	remain	VBG
cord-259237-aty0vrat	119	3	three	three	CD
cord-259237-aty0vrat	119	4	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	119	5	residues	residue	NNS
cord-259237-aty0vrat	119	6	in	in	IN
cord-259237-aty0vrat	119	7	the	the	DT
cord-259237-aty0vrat	119	8	Golgi	Golgi	NNP
cord-259237-aty0vrat	119	9	complex	complex	NN
cord-259237-aty0vrat	119	10	for	for	IN
cord-259237-aty0vrat	119	11	N	n	CD
cord-259237-aty0vrat	119	12	-	-	HYPH
cord-259237-aty0vrat	119	13	glycan	glycan	NN
cord-259237-aty0vrat	119	14	maturation	maturation	NN
cord-259237-aty0vrat	119	15	.	.	.
cord-259237-aty0vrat	120	1	The	the	DT
cord-259237-aty0vrat	120	2	third	third	JJ
cord-259237-aty0vrat	120	3	subfamily	subfamily	NN
cord-259237-aty0vrat	120	4	consists	consist	VBZ
cord-259237-aty0vrat	120	5	of	of	IN
cord-259237-aty0vrat	120	6	the	the	DT
cord-259237-aty0vrat	120	7	ER	ER	NNP
cord-259237-aty0vrat	120	8	degradation	degradation	NN
cord-259237-aty0vrat	120	9	-	-	HYPH
cord-259237-aty0vrat	120	10	enhancing	enhance	VBG
cord-259237-aty0vrat	120	11	α	α	NN
cord-259237-aty0vrat	120	12	-	-	HYPH
cord-259237-aty0vrat	120	13	mannosidase	mannosidase	NN
cord-259237-aty0vrat	120	14	-	-	HYPH
cord-259237-aty0vrat	120	15	like	like	JJ
cord-259237-aty0vrat	120	16	proteins	protein	NNS
cord-259237-aty0vrat	120	17	(	(	-LRB-
cord-259237-aty0vrat	120	18	EDEM	EDEM	NNP
cord-259237-aty0vrat	120	19	)	)	-RRB-
cord-259237-aty0vrat	120	20	1	1	CD
cord-259237-aty0vrat	120	21	,	,	,
cord-259237-aty0vrat	120	22	2	2	CD
cord-259237-aty0vrat	120	23	,	,	,
cord-259237-aty0vrat	120	24	and	and	CC
cord-259237-aty0vrat	120	25	3	3	CD
cord-259237-aty0vrat	120	26	.	.	.
cord-259237-aty0vrat	121	1	Although	although	IN
cord-259237-aty0vrat	121	2	some	some	DT
cord-259237-aty0vrat	121	3	EDEM	EDEM	NNP
cord-259237-aty0vrat	121	4	orthologs	ortholog	NNS
cord-259237-aty0vrat	121	5	in	in	IN
cord-259237-aty0vrat	121	6	lower	low	JJR
cord-259237-aty0vrat	121	7	eukaryotes	eukaryote	NNS
cord-259237-aty0vrat	121	8	have	have	VBP
cord-259237-aty0vrat	121	9	detectable	detectable	JJ
cord-259237-aty0vrat	121	10	α1,2-mannosidase	α1,2-mannosidase	CD
cord-259237-aty0vrat	121	11	activity	activity	NN
cord-259237-aty0vrat	121	12	,	,	,
cord-259237-aty0vrat	121	13	such	such	JJ
cord-259237-aty0vrat	121	14	activity	activity	NN
cord-259237-aty0vrat	121	15	has	have	VBZ
cord-259237-aty0vrat	121	16	not	not	RB
cord-259237-aty0vrat	121	17	been	be	VBN
cord-259237-aty0vrat	121	18	reported	report	VBN
cord-259237-aty0vrat	121	19	for	for	IN
cord-259237-aty0vrat	121	20	any	any	DT
cord-259237-aty0vrat	121	21	mammalian	mammalian	JJ
cord-259237-aty0vrat	121	22	EDEM	EDEM	NNP
cord-259237-aty0vrat	121	23	proteins	protein	NNS
cord-259237-aty0vrat	121	24	in	in	IN
cord-259237-aty0vrat	121	25	vitro	vitro	FW
cord-259237-aty0vrat	121	26	.	.	.
cord-259237-aty0vrat	122	1	Nevertheless	nevertheless	RB
cord-259237-aty0vrat	122	2	,	,	,
cord-259237-aty0vrat	122	3	there	there	EX
cord-259237-aty0vrat	122	4	is	be	VBZ
cord-259237-aty0vrat	122	5	evidence	evidence	NN
cord-259237-aty0vrat	122	6	suggesting	suggest	VBG
cord-259237-aty0vrat	122	7	that	that	IN
cord-259237-aty0vrat	122	8	these	these	DT
cord-259237-aty0vrat	122	9	EDEM	EDEM	NNP
cord-259237-aty0vrat	122	10	proteins	protein	NNS
cord-259237-aty0vrat	122	11	should	should	MD
cord-259237-aty0vrat	122	12	have	have	VB
cord-259237-aty0vrat	122	13	enzymatic	enzymatic	JJ
cord-259237-aty0vrat	122	14	activity	activity	NN
cord-259237-aty0vrat	122	15	in	in	IN
cord-259237-aty0vrat	122	16	vivo	vivo	NNP
cord-259237-aty0vrat	122	17	[	[	-LRB-
cord-259237-aty0vrat	122	18	44	44	CD
cord-259237-aty0vrat	122	19	,	,	,
cord-259237-aty0vrat	122	20	45	45	CD
cord-259237-aty0vrat	122	21	]	]	-RRB-
cord-259237-aty0vrat	122	22	.	.	.
cord-259237-aty0vrat	123	1	Indeed	indeed	RB
cord-259237-aty0vrat	123	2	,	,	,
cord-259237-aty0vrat	123	3	the	the	DT
cord-259237-aty0vrat	123	4	extent	extent	NN
cord-259237-aty0vrat	123	5	of	of	IN
cord-259237-aty0vrat	123	6	Man	Man	NNP
cord-259237-aty0vrat	123	7	excision	excision	NN
cord-259237-aty0vrat	123	8	determines	determine	VBZ
cord-259237-aty0vrat	123	9	the	the	DT
cord-259237-aty0vrat	123	10	fate	fate	NN
cord-259237-aty0vrat	123	11	of	of	IN
cord-259237-aty0vrat	123	12	a	a	DT
cord-259237-aty0vrat	123	13	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	123	14	,	,	,
cord-259237-aty0vrat	123	15	which	which	WDT
cord-259237-aty0vrat	123	16	could	could	MD
cord-259237-aty0vrat	123	17	be	be	VB
cord-259237-aty0vrat	123	18	either	either	RB
cord-259237-aty0vrat	123	19	targeted	target	VBN
cord-259237-aty0vrat	123	20	to	to	IN
cord-259237-aty0vrat	123	21	ERAD	ERAD	NNP
cord-259237-aty0vrat	123	22	for	for	IN
cord-259237-aty0vrat	123	23	degradation	degradation	NN
cord-259237-aty0vrat	123	24	or	or	CC
cord-259237-aty0vrat	123	25	sent	send	VBN
cord-259237-aty0vrat	123	26	to	to	IN
cord-259237-aty0vrat	123	27	the	the	DT
cord-259237-aty0vrat	123	28	Golgi	Golgi	NNP
cord-259237-aty0vrat	123	29	for	for	IN
cord-259237-aty0vrat	123	30	normal	normal	JJ
cord-259237-aty0vrat	123	31	trafficking	trafficking	NN
cord-259237-aty0vrat	123	32	.	.	.
cord-259237-aty0vrat	124	1	ERManI	ERManI	NNP
cord-259237-aty0vrat	124	2	exhibits	exhibit	VBZ
cord-259237-aty0vrat	124	3	a	a	DT
cord-259237-aty0vrat	124	4	slow	slow	JJ
cord-259237-aty0vrat	124	5	rate	rate	NN
cord-259237-aty0vrat	124	6	of	of	IN
cord-259237-aty0vrat	124	7	enzymatic	enzymatic	JJ
cord-259237-aty0vrat	124	8	activity	activity	NN
cord-259237-aty0vrat	124	9	,	,	,
cord-259237-aty0vrat	124	10	which	which	WDT
cord-259237-aty0vrat	124	11	allows	allow	VBZ
cord-259237-aty0vrat	124	12	nascent	nascent	JJ
cord-259237-aty0vrat	124	13	proteins	protein	NNS
cord-259237-aty0vrat	124	14	to	to	TO
cord-259237-aty0vrat	124	15	perform	perform	VB
cord-259237-aty0vrat	124	16	multiple	multiple	JJ
cord-259237-aty0vrat	124	17	rounds	round	NNS
cord-259237-aty0vrat	124	18	of	of	IN
cord-259237-aty0vrat	124	19	reglucosylation	reglucosylation	NN
cord-259237-aty0vrat	124	20	and	and	CC
cord-259237-aty0vrat	124	21	achieve	achieve	VB
cord-259237-aty0vrat	124	22	proper	proper	JJ
cord-259237-aty0vrat	124	23	folding	folding	NN
cord-259237-aty0vrat	124	24	[	[	-LRB-
cord-259237-aty0vrat	124	25	46	46	CD
cord-259237-aty0vrat	124	26	]	]	-RRB-
cord-259237-aty0vrat	124	27	.	.	.
cord-259237-aty0vrat	125	1	Properly	properly	RB
cord-259237-aty0vrat	125	2	folded	fold	VBN
cord-259237-aty0vrat	125	3	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	125	4	should	should	MD
cord-259237-aty0vrat	125	5	have	have	VB
cord-259237-aty0vrat	125	6	one	one	CD
cord-259237-aty0vrat	125	7	Man	Man	NNP
cord-259237-aty0vrat	125	8	residue	residue	NN
cord-259237-aty0vrat	125	9	trimmed	trim	VBN
cord-259237-aty0vrat	125	10	off	off	RP
cord-259237-aty0vrat	125	11	from	from	IN
cord-259237-aty0vrat	125	12	N	n	NN
cord-259237-aty0vrat	125	13	-	-	HYPH
cord-259237-aty0vrat	125	14	glycans	glycan	NNS
cord-259237-aty0vrat	125	15	by	by	IN
cord-259237-aty0vrat	125	16	ERManI.	ERManI.	NNP
cord-259237-aty0vrat	126	1	These	these	DT
cord-259237-aty0vrat	126	2	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	126	3	then	then	RB
cord-259237-aty0vrat	126	4	interact	interact	VBP
cord-259237-aty0vrat	126	5	with	with	IN
cord-259237-aty0vrat	126	6	the	the	DT
cord-259237-aty0vrat	126	7	high	high	JJ
cord-259237-aty0vrat	126	8	-	-	HYPH
cord-259237-aty0vrat	126	9	Man	man	NN
cord-259237-aty0vrat	126	10	binding	binding	NN
cord-259237-aty0vrat	126	11	lectin	lectin	NN
cord-259237-aty0vrat	126	12	,	,	,
cord-259237-aty0vrat	126	13	ER	ER	NNP
cord-259237-aty0vrat	126	14	-	-	HYPH
cord-259237-aty0vrat	126	15	Golgi	Golgi	NNP
cord-259237-aty0vrat	126	16	intermediate	intermediate	JJ
cord-259237-aty0vrat	126	17	compartment	compartment	NN
cord-259237-aty0vrat	126	18	53	53	CD
cord-259237-aty0vrat	126	19	kDa	kDa	NNP
cord-259237-aty0vrat	126	20	protein	protein	NN
cord-259237-aty0vrat	126	21	(	(	-LRB-
cord-259237-aty0vrat	126	22	ERGIC-53	ergic-53	CD
cord-259237-aty0vrat	126	23	)	)	-RRB-
cord-259237-aty0vrat	126	24	[	[	-LRB-
cord-259237-aty0vrat	126	25	47	47	CD
cord-259237-aty0vrat	126	26	]	]	-RRB-
cord-259237-aty0vrat	126	27	,	,	,
cord-259237-aty0vrat	126	28	for	for	IN
cord-259237-aty0vrat	126	29	trafficking	traffic	VBG
cord-259237-aty0vrat	126	30	from	from	IN
cord-259237-aty0vrat	126	31	the	the	DT
cord-259237-aty0vrat	126	32	ER	ER	NNP
cord-259237-aty0vrat	126	33	to	to	IN
cord-259237-aty0vrat	126	34	the	the	DT
cord-259237-aty0vrat	126	35	Golgi	Golgi	NNP
cord-259237-aty0vrat	126	36	(	(	-LRB-
cord-259237-aty0vrat	126	37	Figure	figure	NN
cord-259237-aty0vrat	126	38	1B	1b	CD
cord-259237-aty0vrat	126	39	)	)	-RRB-
cord-259237-aty0vrat	126	40	.	.	.
cord-259237-aty0vrat	127	1	However	however	RB
cord-259237-aty0vrat	127	2	,	,	,
cord-259237-aty0vrat	127	3	if	if	IN
cord-259237-aty0vrat	127	4	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	127	5	are	be	VBP
cord-259237-aty0vrat	127	6	misfolded	misfolde	VBN
cord-259237-aty0vrat	127	7	terminally	terminally	RB
cord-259237-aty0vrat	127	8	,	,	,
cord-259237-aty0vrat	127	9	the	the	DT
cord-259237-aty0vrat	127	10	remaining	remain	VBG
cord-259237-aty0vrat	127	11	three	three	CD
cord-259237-aty0vrat	127	12	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	127	13	residues	residue	NNS
cord-259237-aty0vrat	127	14	are	be	VBP
cord-259237-aty0vrat	127	15	excised	excise	VBN
cord-259237-aty0vrat	127	16	from	from	IN
cord-259237-aty0vrat	127	17	these	these	DT
cord-259237-aty0vrat	127	18	molecules	molecule	NNS
cord-259237-aty0vrat	127	19	,	,	,
cord-259237-aty0vrat	127	20	which	which	WDT
cord-259237-aty0vrat	127	21	targets	target	VBZ
cord-259237-aty0vrat	127	22	misfolded	misfolde	VBN
cord-259237-aty0vrat	127	23	proteins	protein	NNS
cord-259237-aty0vrat	127	24	for	for	IN
cord-259237-aty0vrat	127	25	degradation	degradation	NN
cord-259237-aty0vrat	127	26	[	[	-LRB-
cord-259237-aty0vrat	127	27	48	48	CD
cord-259237-aty0vrat	127	28	]	]	-RRB-
cord-259237-aty0vrat	127	29	.	.	.
cord-259237-aty0vrat	128	1	It	-PRON-	PRP
cord-259237-aty0vrat	128	2	is	be	VBZ
cord-259237-aty0vrat	128	3	still	still	RB
cord-259237-aty0vrat	128	4	not	not	RB
cord-259237-aty0vrat	128	5	completely	completely	RB
cord-259237-aty0vrat	128	6	understood	understand	VBN
cord-259237-aty0vrat	128	7	how	how	WRB
cord-259237-aty0vrat	128	8	misfolded	misfolde	VBN
cord-259237-aty0vrat	128	9	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	128	10	are	be	VBP
cord-259237-aty0vrat	128	11	subjected	subject	VBN
cord-259237-aty0vrat	128	12	to	to	IN
cord-259237-aty0vrat	128	13	such	such	JJ
cord-259237-aty0vrat	128	14	extensive	extensive	JJ
cord-259237-aty0vrat	128	15	demannosylation	demannosylation	NN
cord-259237-aty0vrat	128	16	in	in	IN
cord-259237-aty0vrat	128	17	the	the	DT
cord-259237-aty0vrat	128	18	ER	ER	NNP
cord-259237-aty0vrat	128	19	and	and	CC
cord-259237-aty0vrat	128	20	then	then	RB
cord-259237-aty0vrat	128	21	targeted	target	VBN
cord-259237-aty0vrat	128	22	for	for	IN
cord-259237-aty0vrat	128	23	ERAD	ERAD	NNP
cord-259237-aty0vrat	128	24	.	.	.
cord-259237-aty0vrat	129	1	Although	although	IN
cord-259237-aty0vrat	129	2	ERManI	ERManI	NNP
cord-259237-aty0vrat	129	3	alone	alone	RB
cord-259237-aty0vrat	129	4	may	may	MD
cord-259237-aty0vrat	129	5	be	be	VB
cord-259237-aty0vrat	129	6	able	able	JJ
cord-259237-aty0vrat	129	7	to	to	TO
cord-259237-aty0vrat	129	8	complete	complete	VB
cord-259237-aty0vrat	129	9	this	this	DT
cord-259237-aty0vrat	129	10	task	task	NN
cord-259237-aty0vrat	129	11	,	,	,
cord-259237-aty0vrat	129	12	there	there	EX
cord-259237-aty0vrat	129	13	is	be	VBZ
cord-259237-aty0vrat	129	14	evidence	evidence	NN
cord-259237-aty0vrat	129	15	suggesting	suggest	VBG
cord-259237-aty0vrat	129	16	that	that	IN
cord-259237-aty0vrat	129	17	additional	additional	JJ
cord-259237-aty0vrat	129	18	GH47	GH47	NNP
cord-259237-aty0vrat	129	19	enzymes	enzyme	NNS
cord-259237-aty0vrat	129	20	are	be	VBP
cord-259237-aty0vrat	129	21	involved	involve	VBN
cord-259237-aty0vrat	129	22	.	.	.
cord-259237-aty0vrat	130	1	Elevation	elevation	NN
cord-259237-aty0vrat	130	2	of	of	IN
cord-259237-aty0vrat	130	3	the	the	DT
cord-259237-aty0vrat	130	4	Golgi	Golgi	NNP
cord-259237-aty0vrat	130	5	mannosidases	mannosidase	NNS
cord-259237-aty0vrat	130	6	has	have	VBZ
cord-259237-aty0vrat	130	7	been	be	VBN
cord-259237-aty0vrat	130	8	shown	show	VBN
cord-259237-aty0vrat	130	9	to	to	TO
cord-259237-aty0vrat	130	10	accelerate	accelerate	VB
cord-259237-aty0vrat	130	11	ERAD	ERAD	NNP
cord-259237-aty0vrat	130	12	,	,	,
cord-259237-aty0vrat	130	13	so	so	IN
cord-259237-aty0vrat	130	14	these	these	DT
cord-259237-aty0vrat	130	15	enzymes	enzyme	NNS
cord-259237-aty0vrat	130	16	may	may	MD
cord-259237-aty0vrat	130	17	possibly	possibly	RB
cord-259237-aty0vrat	130	18	be	be	VB
cord-259237-aty0vrat	130	19	responsible	responsible	JJ
cord-259237-aty0vrat	130	20	for	for	IN
cord-259237-aty0vrat	130	21	such	such	JJ
cord-259237-aty0vrat	130	22	extensive	extensive	JJ
cord-259237-aty0vrat	130	23	excision	excision	NN
cord-259237-aty0vrat	130	24	,	,	,
cord-259237-aty0vrat	130	25	likely	likely	JJ
cord-259237-aty0vrat	130	26	by	by	IN
cord-259237-aty0vrat	130	27	trafficking	traffic	VBG
cord-259237-aty0vrat	130	28	back	back	RB
cord-259237-aty0vrat	130	29	to	to	IN
cord-259237-aty0vrat	130	30	the	the	DT
cord-259237-aty0vrat	130	31	ER	ER	NNP
cord-259237-aty0vrat	130	32	via	via	IN
cord-259237-aty0vrat	130	33	an	an	DT
cord-259237-aty0vrat	130	34	unknown	unknown	JJ
cord-259237-aty0vrat	130	35	mechanism	mechanism	NN
cord-259237-aty0vrat	130	36	[	[	-LRB-
cord-259237-aty0vrat	130	37	49	49	CD
cord-259237-aty0vrat	130	38	]	]	-RRB-
cord-259237-aty0vrat	130	39	.	.	.
cord-259237-aty0vrat	131	1	In	in	IN
cord-259237-aty0vrat	131	2	fact	fact	NN
cord-259237-aty0vrat	131	3	,	,	,
cord-259237-aty0vrat	131	4	the	the	DT
cord-259237-aty0vrat	131	5	localization	localization	NN
cord-259237-aty0vrat	131	6	of	of	IN
cord-259237-aty0vrat	131	7	the	the	DT
cord-259237-aty0vrat	131	8	GolgiManIA	golgimania	NN
cord-259237-aty0vrat	131	9	has	have	VBZ
cord-259237-aty0vrat	131	10	recently	recently	RB
cord-259237-aty0vrat	131	11	been	be	VBN
cord-259237-aty0vrat	131	12	observed	observe	VBN
cord-259237-aty0vrat	131	13	in	in	IN
cord-259237-aty0vrat	131	14	QCV	QCV	NNP
cord-259237-aty0vrat	131	15	with	with	IN
cord-259237-aty0vrat	131	16	other	other	JJ
cord-259237-aty0vrat	131	17	canonical	canonical	JJ
cord-259237-aty0vrat	131	18	ERAD	ERAD	NNP
cord-259237-aty0vrat	131	19	machinery	machinery	NN
cord-259237-aty0vrat	131	20	such	such	JJ
cord-259237-aty0vrat	131	21	as	as	IN
cord-259237-aty0vrat	131	22	ERManI	ERManI	NNP
cord-259237-aty0vrat	131	23	,	,	,
cord-259237-aty0vrat	131	24	and	and	CC
cord-259237-aty0vrat	131	25	overexpression	overexpression	NN
cord-259237-aty0vrat	131	26	and	and	CC
cord-259237-aty0vrat	131	27	knockdown	knockdown	NN
cord-259237-aty0vrat	131	28	can	can	MD
cord-259237-aty0vrat	131	29	,	,	,
cord-259237-aty0vrat	131	30	respectively	respectively	RB
cord-259237-aty0vrat	131	31	,	,	,
cord-259237-aty0vrat	131	32	increase	increase	VB
cord-259237-aty0vrat	131	33	or	or	CC
cord-259237-aty0vrat	131	34	retard	retard	NN
cord-259237-aty0vrat	131	35	trimming	trimming	NN
cord-259237-aty0vrat	131	36	of	of	IN
cord-259237-aty0vrat	131	37	misfolded	misfolde	VBN
cord-259237-aty0vrat	131	38	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	131	39	from	from	IN
cord-259237-aty0vrat	131	40	Man	Man	NNP
cord-259237-aty0vrat	131	41	9	9	CD
cord-259237-aty0vrat	131	42	GlcNAc	glcnac	NN
cord-259237-aty0vrat	131	43	2	2	CD
cord-259237-aty0vrat	131	44	to	to	IN
cord-259237-aty0vrat	131	45	Man	man	NN
cord-259237-aty0vrat	131	46	5	5	CD
cord-259237-aty0vrat	132	1	GlcNAc	glcnac	NN
cord-259237-aty0vrat	132	2	2	2	CD
cord-259237-aty0vrat	133	1	in	in	IN
cord-259237-aty0vrat	133	2	vitro	vitro	FW
cord-259237-aty0vrat	133	3	[	[	-LRB-
cord-259237-aty0vrat	133	4	50	50	CD
cord-259237-aty0vrat	133	5	]	]	-RRB-
cord-259237-aty0vrat	133	6	.	.	.
cord-259237-aty0vrat	134	1	In	in	IN
cord-259237-aty0vrat	134	2	addition	addition	NN
cord-259237-aty0vrat	134	3	,	,	,
cord-259237-aty0vrat	134	4	upon	upon	IN
cord-259237-aty0vrat	134	5	ER	ER	NNP
cord-259237-aty0vrat	134	6	stress	stress	NN
cord-259237-aty0vrat	134	7	,	,	,
cord-259237-aty0vrat	134	8	QCV	QCV	NNP
cord-259237-aty0vrat	134	9	converge	converge	VBP
cord-259237-aty0vrat	134	10	to	to	TO
cord-259237-aty0vrat	134	11	form	form	VB
cord-259237-aty0vrat	134	12	the	the	DT
cord-259237-aty0vrat	134	13	ER	er	NN
cord-259237-aty0vrat	134	14	-	-	HYPH
cord-259237-aty0vrat	134	15	derived	derive	VBN
cord-259237-aty0vrat	134	16	quality	quality	NN
cord-259237-aty0vrat	134	17	compartments	compartment	NNS
cord-259237-aty0vrat	134	18	(	(	-LRB-
cord-259237-aty0vrat	134	19	ERQC	ERQC	NNP
cord-259237-aty0vrat	134	20	)	)	-RRB-
cord-259237-aty0vrat	134	21	,	,	,
cord-259237-aty0vrat	134	22	where	where	WRB
cord-259237-aty0vrat	134	23	EDEM	EDEM	NNP
cord-259237-aty0vrat	134	24	proteins	protein	NNS
cord-259237-aty0vrat	134	25	are	be	VBP
cord-259237-aty0vrat	134	26	also	also	RB
cord-259237-aty0vrat	134	27	sequestered	sequester	VBN
cord-259237-aty0vrat	134	28	(	(	-LRB-
cord-259237-aty0vrat	134	29	Figure	figure	NN
cord-259237-aty0vrat	134	30	1B	1b	CD
cord-259237-aty0vrat	134	31	)	)	-RRB-
cord-259237-aty0vrat	134	32	[	[	-LRB-
cord-259237-aty0vrat	134	33	48	48	CD
cord-259237-aty0vrat	134	34	]	]	-RRB-
cord-259237-aty0vrat	134	35	.	.	.
cord-259237-aty0vrat	135	1	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	136	1	and	and	CC
cord-259237-aty0vrat	136	2	EDEM3	EDEM3	NNP
cord-259237-aty0vrat	136	3	boost	boost	NN
cord-259237-aty0vrat	136	4	mannose	mannose	NN
cord-259237-aty0vrat	136	5	trimming	trimming	NN
cord-259237-aty0vrat	136	6	when	when	WRB
cord-259237-aty0vrat	136	7	overexpressed	overexpresse	VBN
cord-259237-aty0vrat	136	8	[	[	-LRB-
cord-259237-aty0vrat	136	9	45	45	CD
cord-259237-aty0vrat	136	10	,	,	,
cord-259237-aty0vrat	136	11	51	51	CD
cord-259237-aty0vrat	136	12	,	,	,
cord-259237-aty0vrat	136	13	52	52	CD
cord-259237-aty0vrat	136	14	]	]	-RRB-
cord-259237-aty0vrat	136	15	.	.	.
cord-259237-aty0vrat	137	1	In	in	IN
cord-259237-aty0vrat	137	2	addition	addition	NN
cord-259237-aty0vrat	137	3	,	,	,
cord-259237-aty0vrat	137	4	using	use	VBG
cord-259237-aty0vrat	137	5	a	a	DT
cord-259237-aty0vrat	137	6	genomic	genomic	JJ
cord-259237-aty0vrat	137	7	knockout	knockout	NN
cord-259237-aty0vrat	137	8	approach	approach	NN
cord-259237-aty0vrat	137	9	,	,	,
cord-259237-aty0vrat	137	10	it	-PRON-	PRP
cord-259237-aty0vrat	137	11	has	have	VBZ
cord-259237-aty0vrat	137	12	been	be	VBN
cord-259237-aty0vrat	137	13	recently	recently	RB
cord-259237-aty0vrat	137	14	proposed	propose	VBN
cord-259237-aty0vrat	137	15	that	that	IN
cord-259237-aty0vrat	137	16	EDEM2	EDEM2	NNP
cord-259237-aty0vrat	137	17	plays	play	VBZ
cord-259237-aty0vrat	137	18	a	a	DT
cord-259237-aty0vrat	137	19	central	central	JJ
cord-259237-aty0vrat	137	20	role	role	NN
cord-259237-aty0vrat	137	21	in	in	IN
cord-259237-aty0vrat	137	22	the	the	DT
cord-259237-aty0vrat	137	23	trimming	trimming	NN
cord-259237-aty0vrat	137	24	of	of	IN
cord-259237-aty0vrat	137	25	the	the	DT
cord-259237-aty0vrat	137	26	outmost	outmost	JJ
cord-259237-aty0vrat	137	27	Man	man	NN
cord-259237-aty0vrat	137	28	residue	residue	NN
cord-259237-aty0vrat	137	29	on	on	IN
cord-259237-aty0vrat	137	30	the	the	DT
cord-259237-aty0vrat	137	31	b	b	NN
cord-259237-aty0vrat	137	32	branch	branch	NN
cord-259237-aty0vrat	137	33	,	,	,
cord-259237-aty0vrat	137	34	whereas	whereas	IN
cord-259237-aty0vrat	137	35	EDEM1	EDEM1	NNS
cord-259237-aty0vrat	137	36	and	and	CC
cord-259237-aty0vrat	137	37	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	137	38	should	should	MD
cord-259237-aty0vrat	137	39	be	be	VB
cord-259237-aty0vrat	137	40	responsible	responsible	JJ
cord-259237-aty0vrat	137	41	for	for	IN
cord-259237-aty0vrat	137	42	trimming	trim	VBG
cord-259237-aty0vrat	137	43	of	of	IN
cord-259237-aty0vrat	137	44	the	the	DT
cord-259237-aty0vrat	137	45	remaining	remain	VBG
cord-259237-aty0vrat	137	46	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	137	47	residues	residue	NNS
cord-259237-aty0vrat	137	48	.	.	.
cord-259237-aty0vrat	138	1	Accordingly	accordingly	RB
cord-259237-aty0vrat	138	2	,	,	,
cord-259237-aty0vrat	138	3	a	a	DT
cord-259237-aty0vrat	138	4	"	"	``
cord-259237-aty0vrat	138	5	double	double	JJ
cord-259237-aty0vrat	138	6	check	check	NN
cord-259237-aty0vrat	138	7	"	"	''
cord-259237-aty0vrat	138	8	model	model	NN
cord-259237-aty0vrat	138	9	for	for	IN
cord-259237-aty0vrat	138	10	misfolded	misfolded	JJ
cord-259237-aty0vrat	138	11	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	138	12	has	have	VBZ
cord-259237-aty0vrat	138	13	been	be	VBN
cord-259237-aty0vrat	138	14	proposed	propose	VBN
cord-259237-aty0vrat	138	15	,	,	,
cord-259237-aty0vrat	138	16	which	which	WDT
cord-259237-aty0vrat	138	17	suggests	suggest	VBZ
cord-259237-aty0vrat	138	18	that	that	IN
cord-259237-aty0vrat	138	19	EDEM2	edem2	NN
cord-259237-aty0vrat	138	20	catalyzes	catalyze	VBZ
cord-259237-aty0vrat	138	21	the	the	DT
cord-259237-aty0vrat	138	22	first	first	JJ
cord-259237-aty0vrat	138	23	step	step	NN
cord-259237-aty0vrat	138	24	of	of	IN
cord-259237-aty0vrat	138	25	Man	Man	NNP
cord-259237-aty0vrat	138	26	trimming	trimming	NN
cord-259237-aty0vrat	138	27	,	,	,
cord-259237-aty0vrat	138	28	and	and	CC
cord-259237-aty0vrat	138	29	EDEM1	EDEM1	NNS
cord-259237-aty0vrat	138	30	and	and	CC
cord-259237-aty0vrat	138	31	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	138	32	contribute	contribute	VBP
cord-259237-aty0vrat	138	33	the	the	DT
cord-259237-aty0vrat	138	34	second	second	JJ
cord-259237-aty0vrat	138	35	step	step	NN
cord-259237-aty0vrat	138	36	[	[	-LRB-
cord-259237-aty0vrat	138	37	44	44	CD
cord-259237-aty0vrat	138	38	]	]	-RRB-
cord-259237-aty0vrat	138	39	.	.	.
cord-259237-aty0vrat	139	1	Under	under	IN
cord-259237-aty0vrat	139	2	these	these	DT
cord-259237-aty0vrat	139	3	joint	joint	JJ
cord-259237-aty0vrat	139	4	actions	action	NNS
cord-259237-aty0vrat	139	5	,	,	,
cord-259237-aty0vrat	139	6	all	all	DT
cord-259237-aty0vrat	139	7	four	four	CD
cord-259237-aty0vrat	139	8	α1,2-Man	α1,2-man	CD
cord-259237-aty0vrat	139	9	residues	residue	NNS
cord-259237-aty0vrat	139	10	are	be	VBP
cord-259237-aty0vrat	139	11	removed	remove	VBN
cord-259237-aty0vrat	139	12	from	from	IN
cord-259237-aty0vrat	139	13	the	the	DT
cord-259237-aty0vrat	139	14	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	139	15	,	,	,
cord-259237-aty0vrat	139	16	which	which	WDT
cord-259237-aty0vrat	139	17	is	be	VBZ
cord-259237-aty0vrat	139	18	then	then	RB
cord-259237-aty0vrat	139	19	recognized	recognize	VBN
cord-259237-aty0vrat	139	20	by	by	IN
cord-259237-aty0vrat	139	21	the	the	DT
cord-259237-aty0vrat	139	22	lectins	lectin	NNS
cord-259237-aty0vrat	139	23	osteosarcoma	osteosarcoma	NN
cord-259237-aty0vrat	139	24	amplified	amplify	VBD
cord-259237-aty0vrat	139	25	9	9	CD
cord-259237-aty0vrat	139	26	(	(	-LRB-
cord-259237-aty0vrat	139	27	OS9	OS9	NNP
cord-259237-aty0vrat	139	28	)	)	-RRB-
cord-259237-aty0vrat	139	29	and	and	CC
cord-259237-aty0vrat	139	30	XTP3-transactivated	XTP3-transactivated	NNP
cord-259237-aty0vrat	139	31	gene	gene	NN
cord-259237-aty0vrat	139	32	B	B	NNP
cord-259237-aty0vrat	139	33	protein	protein	NN
cord-259237-aty0vrat	139	34	(	(	-LRB-
cord-259237-aty0vrat	139	35	XTP3-B	XTP3-B	NNP
cord-259237-aty0vrat	139	36	)	)	-RRB-
cord-259237-aty0vrat	139	37	via	via	IN
cord-259237-aty0vrat	139	38	the	the	DT
cord-259237-aty0vrat	139	39	mannose	mannose	NN
cord-259237-aty0vrat	139	40	6-phosphate	6-phosphate	NN
cord-259237-aty0vrat	139	41	receptor	receptor	NN
cord-259237-aty0vrat	139	42	homology	homology	NN
cord-259237-aty0vrat	139	43	(	(	-LRB-
cord-259237-aty0vrat	139	44	MRH	MRH	NNP
cord-259237-aty0vrat	139	45	)	)	-RRB-
cord-259237-aty0vrat	139	46	domain	domain	NN
cord-259237-aty0vrat	139	47	(	(	-LRB-
cord-259237-aty0vrat	139	48	Figure	figure	NN
cord-259237-aty0vrat	139	49	1B	1b	CD
cord-259237-aty0vrat	139	50	)	)	-RRB-
cord-259237-aty0vrat	139	51	[	[	-LRB-
cord-259237-aty0vrat	139	52	53	53	CD
cord-259237-aty0vrat	139	53	,	,	,
cord-259237-aty0vrat	139	54	54	54	CD
cord-259237-aty0vrat	139	55	]	]	-RRB-
cord-259237-aty0vrat	139	56	.	.	.
cord-259237-aty0vrat	140	1	Misfolded	Misfolded	NNP
cord-259237-aty0vrat	140	2	proteins	protein	NNS
cord-259237-aty0vrat	140	3	are	be	VBP
cord-259237-aty0vrat	140	4	targeted	target	VBN
cord-259237-aty0vrat	140	5	to	to	IN
cord-259237-aty0vrat	140	6	specific	specific	JJ
cord-259237-aty0vrat	140	7	translocation	translocation	NN
cord-259237-aty0vrat	140	8	channels	channel	NNS
cord-259237-aty0vrat	140	9	(	(	-LRB-
cord-259237-aty0vrat	140	10	retrotranslocons	retrotranslocon	NNS
cord-259237-aty0vrat	140	11	)	)	-RRB-
cord-259237-aty0vrat	140	12	for	for	IN
cord-259237-aty0vrat	140	13	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	140	14	in	in	IN
cord-259237-aty0vrat	140	15	an	an	DT
cord-259237-aty0vrat	140	16	energy	energy	NN
cord-259237-aty0vrat	140	17	-	-	HYPH
cord-259237-aty0vrat	140	18	dependent	dependent	JJ
cord-259237-aty0vrat	140	19	manner	manner	NN
cord-259237-aty0vrat	140	20	.	.	.
cord-259237-aty0vrat	141	1	This	this	DT
cord-259237-aty0vrat	141	2	process	process	NN
cord-259237-aty0vrat	141	3	is	be	VBZ
cord-259237-aty0vrat	141	4	facilitated	facilitate	VBN
cord-259237-aty0vrat	141	5	by	by	IN
cord-259237-aty0vrat	141	6	p97	p97	CD
cord-259237-aty0vrat	141	7	,	,	,
cord-259237-aty0vrat	141	8	a	a	DT
cord-259237-aty0vrat	141	9	member	member	NN
cord-259237-aty0vrat	141	10	of	of	IN
cord-259237-aty0vrat	141	11	the	the	DT
cord-259237-aty0vrat	141	12	ATPases	atpase	NNS
cord-259237-aty0vrat	141	13	associated	associate	VBN
cord-259237-aty0vrat	141	14	with	with	IN
cord-259237-aty0vrat	141	15	the	the	DT
cord-259237-aty0vrat	141	16	diverse	diverse	JJ
cord-259237-aty0vrat	141	17	cellular	cellular	JJ
cord-259237-aty0vrat	141	18	activities	activity	NNS
cord-259237-aty0vrat	141	19	(	(	-LRB-
cord-259237-aty0vrat	141	20	AAA	AAA	NNP
cord-259237-aty0vrat	141	21	)	)	-RRB-
cord-259237-aty0vrat	141	22	family	family	NN
cord-259237-aty0vrat	141	23	,	,	,
cord-259237-aty0vrat	141	24	by	by	IN
cord-259237-aty0vrat	141	25	catalyzing	catalyze	VBG
cord-259237-aty0vrat	141	26	ATP	ATP	NNP
cord-259237-aty0vrat	141	27	hydrolysis	hydrolysis	NN
cord-259237-aty0vrat	141	28	[	[	-LRB-
cord-259237-aty0vrat	141	29	55	55	CD
cord-259237-aty0vrat	141	30	]	]	-RRB-
cord-259237-aty0vrat	141	31	.	.	.
cord-259237-aty0vrat	142	1	The	the	DT
cord-259237-aty0vrat	142	2	p97	p97	CD
cord-259237-aty0vrat	142	3	ATPase	ATPase	NNP
cord-259237-aty0vrat	142	4	is	be	VBZ
cord-259237-aty0vrat	142	5	recruited	recruit	VBN
cord-259237-aty0vrat	142	6	by	by	IN
cord-259237-aty0vrat	142	7	the	the	DT
cord-259237-aty0vrat	142	8	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	142	9	-	-	HYPH
cord-259237-aty0vrat	142	10	like	like	JJ
cord-259237-aty0vrat	142	11	(	(	-LRB-
cord-259237-aty0vrat	142	12	UBX)-domain	ubx)-domain	ADD
cord-259237-aty0vrat	142	13	-	-	HYPH
cord-259237-aty0vrat	142	14	containing	contain	VBG
cord-259237-aty0vrat	142	15	protein	protein	NN
cord-259237-aty0vrat	142	16	Ubxd8	Ubxd8	NNP
cord-259237-aty0vrat	142	17	,	,	,
cord-259237-aty0vrat	142	18	an	an	DT
cord-259237-aty0vrat	142	19	ER	er	NN
cord-259237-aty0vrat	142	20	-	-	HYPH
cord-259237-aty0vrat	142	21	membrane	membrane	NN
cord-259237-aty0vrat	142	22	protein	protein	NN
cord-259237-aty0vrat	142	23	that	that	WDT
cord-259237-aty0vrat	142	24	plays	play	VBZ
cord-259237-aty0vrat	142	25	a	a	DT
cord-259237-aty0vrat	142	26	role	role	NN
cord-259237-aty0vrat	142	27	in	in	IN
cord-259237-aty0vrat	142	28	ERAD	ERAD	NNP
cord-259237-aty0vrat	142	29	[	[	-LRB-
cord-259237-aty0vrat	142	30	56	56	CD
cord-259237-aty0vrat	142	31	]	]	-RRB-
cord-259237-aty0vrat	142	32	.	.	.
cord-259237-aty0vrat	143	1	It	-PRON-	PRP
cord-259237-aty0vrat	143	2	is	be	VBZ
cord-259237-aty0vrat	143	3	still	still	RB
cord-259237-aty0vrat	143	4	mysterious	mysterious	JJ
cord-259237-aty0vrat	143	5	how	how	WRB
cord-259237-aty0vrat	143	6	these	these	DT
cord-259237-aty0vrat	143	7	retrotranslocons	retrotranslocon	NNS
cord-259237-aty0vrat	143	8	are	be	VBP
cord-259237-aty0vrat	143	9	formed	form	VBN
cord-259237-aty0vrat	143	10	and	and	CC
cord-259237-aty0vrat	143	11	how	how	WRB
cord-259237-aty0vrat	143	12	integral	integral	JJ
cord-259237-aty0vrat	143	13	membrane	membrane	NN
cord-259237-aty0vrat	143	14	and	and	CC
cord-259237-aty0vrat	143	15	lumenal	lumenal	JJ
cord-259237-aty0vrat	143	16	ERAD	ERAD	NNP
cord-259237-aty0vrat	143	17	substrates	substrate	NNS
cord-259237-aty0vrat	143	18	are	be	VBP
cord-259237-aty0vrat	143	19	exported	export	VBN
cord-259237-aty0vrat	143	20	across	across	IN
cord-259237-aty0vrat	143	21	the	the	DT
cord-259237-aty0vrat	143	22	ER	ER	NNP
cord-259237-aty0vrat	143	23	membrane	membrane	NN
cord-259237-aty0vrat	143	24	through	through	IN
cord-259237-aty0vrat	143	25	these	these	DT
cord-259237-aty0vrat	143	26	retrotranslocons	retrotranslocon	NNS
cord-259237-aty0vrat	143	27	.	.	.
cord-259237-aty0vrat	144	1	The	the	DT
cord-259237-aty0vrat	144	2	first	first	JJ
cord-259237-aty0vrat	144	3	candidate	candidate	NN
cord-259237-aty0vrat	144	4	channel	channel	NN
cord-259237-aty0vrat	144	5	is	be	VBZ
cord-259237-aty0vrat	144	6	composed	compose	VBN
cord-259237-aty0vrat	144	7	of	of	IN
cord-259237-aty0vrat	144	8	the	the	DT
cord-259237-aty0vrat	144	9	Sec61	Sec61	NNP
cord-259237-aty0vrat	144	10	complex	complex	NN
cord-259237-aty0vrat	144	11	,	,	,
cord-259237-aty0vrat	144	12	which	which	WDT
cord-259237-aty0vrat	144	13	is	be	VBZ
cord-259237-aty0vrat	144	14	comprised	comprise	VBN
cord-259237-aty0vrat	144	15	of	of	IN
cord-259237-aty0vrat	144	16	α	α	NNP
cord-259237-aty0vrat	144	17	,	,	,
cord-259237-aty0vrat	144	18	β	β	NN
cord-259237-aty0vrat	144	19	,	,	,
cord-259237-aty0vrat	144	20	and	and	CC
cord-259237-aty0vrat	144	21	γ	γ	NN
cord-259237-aty0vrat	144	22	subunits	subunit	NNS
cord-259237-aty0vrat	144	23	.	.	.
cord-259237-aty0vrat	145	1	The	the	DT
cord-259237-aty0vrat	145	2	α	α	NNP
cord-259237-aty0vrat	145	3	subunit	subunit	NN
cord-259237-aty0vrat	145	4	crosses	cross	VBZ
cord-259237-aty0vrat	145	5	the	the	DT
cord-259237-aty0vrat	145	6	membrane	membrane	NN
cord-259237-aty0vrat	145	7	10	10	CD
cord-259237-aty0vrat	145	8	times	time	NNS
cord-259237-aty0vrat	145	9	,	,	,
cord-259237-aty0vrat	145	10	and	and	CC
cord-259237-aty0vrat	145	11	forms	form	VBZ
cord-259237-aty0vrat	145	12	a	a	DT
cord-259237-aty0vrat	145	13	channel	channel	NN
cord-259237-aty0vrat	145	14	with	with	IN
cord-259237-aty0vrat	145	15	the	the	DT
cord-259237-aty0vrat	145	16	other	other	JJ
cord-259237-aty0vrat	145	17	subunits	subunit	NNS
cord-259237-aty0vrat	145	18	.	.	.
cord-259237-aty0vrat	146	1	The	the	DT
cord-259237-aty0vrat	146	2	Sec61	Sec61	NNP
cord-259237-aty0vrat	146	3	heterotrimeric	heterotrimeric	NN
cord-259237-aty0vrat	146	4	channel	channel	NN
cord-259237-aty0vrat	146	5	is	be	VBZ
cord-259237-aty0vrat	146	6	the	the	DT
cord-259237-aty0vrat	146	7	main	main	JJ
cord-259237-aty0vrat	146	8	translocon	translocon	NN
cord-259237-aty0vrat	146	9	involved	involve	VBN
cord-259237-aty0vrat	146	10	in	in	IN
cord-259237-aty0vrat	146	11	co	co	JJ
cord-259237-aty0vrat	146	12	-	-	JJ
cord-259237-aty0vrat	146	13	translational	translational	JJ
cord-259237-aty0vrat	146	14	protein	protein	NN
cord-259237-aty0vrat	146	15	transport	transport	NN
cord-259237-aty0vrat	146	16	into	into	IN
cord-259237-aty0vrat	146	17	the	the	DT
cord-259237-aty0vrat	146	18	ER	ER	NNP
cord-259237-aty0vrat	146	19	[	[	-LRB-
cord-259237-aty0vrat	146	20	57	57	CD
cord-259237-aty0vrat	146	21	]	]	-RRB-
cord-259237-aty0vrat	146	22	.	.	.
cord-259237-aty0vrat	147	1	However	however	RB
cord-259237-aty0vrat	147	2	,	,	,
cord-259237-aty0vrat	147	3	there	there	EX
cord-259237-aty0vrat	147	4	is	be	VBZ
cord-259237-aty0vrat	147	5	evidence	evidence	NN
cord-259237-aty0vrat	147	6	suggesting	suggest	VBG
cord-259237-aty0vrat	147	7	that	that	IN
cord-259237-aty0vrat	147	8	the	the	DT
cord-259237-aty0vrat	147	9	Sec61	Sec61	NNP
cord-259237-aty0vrat	147	10	translocon	translocon	NN
cord-259237-aty0vrat	147	11	is	be	VBZ
cord-259237-aty0vrat	147	12	also	also	RB
cord-259237-aty0vrat	147	13	involved	involve	VBN
cord-259237-aty0vrat	147	14	in	in	IN
cord-259237-aty0vrat	147	15	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	147	16	of	of	IN
cord-259237-aty0vrat	147	17	ERAD	ERAD	NNP
cord-259237-aty0vrat	147	18	substrates	substrate	NNS
cord-259237-aty0vrat	147	19	,	,	,
cord-259237-aty0vrat	147	20	implying	imply	VBG
cord-259237-aty0vrat	147	21	the	the	DT
cord-259237-aty0vrat	147	22	non	non	JJ
cord-259237-aty0vrat	147	23	-	-	JJ
cord-259237-aty0vrat	147	24	specificity	specificity	JJ
cord-259237-aty0vrat	147	25	and	and	CC
cord-259237-aty0vrat	147	26	bi	bi	JJ
cord-259237-aty0vrat	147	27	-	-	JJ
cord-259237-aty0vrat	147	28	directional	directional	JJ
cord-259237-aty0vrat	147	29	property	property	NN
cord-259237-aty0vrat	147	30	of	of	IN
cord-259237-aty0vrat	147	31	this	this	DT
cord-259237-aty0vrat	147	32	channel	channel	NN
cord-259237-aty0vrat	147	33	[	[	-LRB-
cord-259237-aty0vrat	147	34	58	58	CD
cord-259237-aty0vrat	147	35	]	]	-RRB-
cord-259237-aty0vrat	147	36	.	.	.
cord-259237-aty0vrat	148	1	The	the	DT
cord-259237-aty0vrat	148	2	second	second	JJ
cord-259237-aty0vrat	148	3	candidate	candidate	NN
cord-259237-aty0vrat	148	4	is	be	VBZ
cord-259237-aty0vrat	148	5	a	a	DT
cord-259237-aty0vrat	148	6	member	member	NN
cord-259237-aty0vrat	148	7	of	of	IN
cord-259237-aty0vrat	148	8	the	the	DT
cord-259237-aty0vrat	148	9	Derlin	Derlin	NNP
cord-259237-aty0vrat	148	10	family	family	NN
cord-259237-aty0vrat	148	11	(	(	-LRB-
cord-259237-aty0vrat	148	12	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	148	13	,	,	,
cord-259237-aty0vrat	148	14	-2	-2	NNP
cord-259237-aty0vrat	148	15	,	,	,
cord-259237-aty0vrat	148	16	and	and	CC
cord-259237-aty0vrat	148	17	-3	-3	NNP
cord-259237-aty0vrat	148	18	)	)	-RRB-
cord-259237-aty0vrat	149	1	[	[	-LRB-
cord-259237-aty0vrat	149	2	59	59	CD
cord-259237-aty0vrat	149	3	,	,	,
cord-259237-aty0vrat	149	4	60	60	CD
cord-259237-aty0vrat	149	5	]	]	-RRB-
cord-259237-aty0vrat	149	6	.	.	.
cord-259237-aty0vrat	150	1	Derlins	derlin	NNS
cord-259237-aty0vrat	150	2	are	be	VBP
cord-259237-aty0vrat	150	3	integral	integral	JJ
cord-259237-aty0vrat	150	4	membrane	membrane	NN
cord-259237-aty0vrat	150	5	proteins	protein	NNS
cord-259237-aty0vrat	150	6	that	that	WDT
cord-259237-aty0vrat	150	7	likely	likely	RB
cord-259237-aty0vrat	150	8	span	span	VBP
cord-259237-aty0vrat	150	9	the	the	DT
cord-259237-aty0vrat	150	10	ER	ER	NNP
cord-259237-aty0vrat	150	11	membrane	membrane	NN
cord-259237-aty0vrat	150	12	four	four	CD
cord-259237-aty0vrat	150	13	times	time	NNS
cord-259237-aty0vrat	150	14	and	and	CC
cord-259237-aty0vrat	150	15	contain	contain	VBP
cord-259237-aty0vrat	150	16	a	a	DT
cord-259237-aty0vrat	150	17	rhomboid	rhomboid	JJ
cord-259237-aty0vrat	150	18	-	-	HYPH
cord-259237-aty0vrat	150	19	like	like	JJ
cord-259237-aty0vrat	150	20	domain	domain	NN
cord-259237-aty0vrat	150	21	[	[	-LRB-
cord-259237-aty0vrat	150	22	61	61	CD
cord-259237-aty0vrat	150	23	]	]	-RRB-
cord-259237-aty0vrat	150	24	.	.	.
cord-259237-aty0vrat	151	1	The	the	DT
cord-259237-aty0vrat	151	2	third	third	JJ
cord-259237-aty0vrat	151	3	candidate	candidate	NN
cord-259237-aty0vrat	151	4	includes	include	VBZ
cord-259237-aty0vrat	151	5	the	the	DT
cord-259237-aty0vrat	151	6	ERAD	ERAD	NNP
cord-259237-aty0vrat	151	7	-	-	HYPH
cord-259237-aty0vrat	151	8	specific	specific	JJ
cord-259237-aty0vrat	151	9	E3	e3	NN
cord-259237-aty0vrat	151	10	ligases	ligase	NNS
cord-259237-aty0vrat	151	11	.	.	.
cord-259237-aty0vrat	152	1	They	-PRON-	PRP
cord-259237-aty0vrat	152	2	have	have	VBP
cord-259237-aty0vrat	152	3	a	a	DT
cord-259237-aty0vrat	152	4	large	large	JJ
cord-259237-aty0vrat	152	5	number	number	NN
cord-259237-aty0vrat	152	6	of	of	IN
cord-259237-aty0vrat	152	7	transmembrane	transmembrane	NN
cord-259237-aty0vrat	152	8	domains	domain	NNS
cord-259237-aty0vrat	152	9	,	,	,
cord-259237-aty0vrat	152	10	which	which	WDT
cord-259237-aty0vrat	152	11	are	be	VBP
cord-259237-aty0vrat	152	12	not	not	RB
cord-259237-aty0vrat	152	13	only	only	RB
cord-259237-aty0vrat	152	14	responsible	responsible	JJ
cord-259237-aty0vrat	152	15	for	for	IN
cord-259237-aty0vrat	152	16	polyubiquitylation	polyubiquitylation	NN
cord-259237-aty0vrat	152	17	,	,	,
cord-259237-aty0vrat	152	18	but	but	CC
cord-259237-aty0vrat	152	19	could	could	MD
cord-259237-aty0vrat	152	20	act	act	VB
cord-259237-aty0vrat	152	21	as	as	IN
cord-259237-aty0vrat	152	22	potential	potential	JJ
cord-259237-aty0vrat	152	23	exit	exit	NN
cord-259237-aty0vrat	152	24	channels	channel	NNS
cord-259237-aty0vrat	152	25	for	for	IN
cord-259237-aty0vrat	152	26	ERAD	ERAD	NNP
cord-259237-aty0vrat	152	27	substrates	substrate	NNS
cord-259237-aty0vrat	152	28	[	[	-LRB-
cord-259237-aty0vrat	152	29	62	62	CD
cord-259237-aty0vrat	152	30	]	]	-RRB-
cord-259237-aty0vrat	152	31	.	.	.
cord-259237-aty0vrat	153	1	In	in	IN
cord-259237-aty0vrat	153	2	Saccharomyces	saccharomyce	NNS
cord-259237-aty0vrat	153	3	cerevisiae	cerevisiae	NNS
cord-259237-aty0vrat	153	4	,	,	,
cord-259237-aty0vrat	153	5	there	there	EX
cord-259237-aty0vrat	153	6	are	be	VBP
cord-259237-aty0vrat	153	7	two	two	CD
cord-259237-aty0vrat	153	8	major	major	JJ
cord-259237-aty0vrat	153	9	types	type	NNS
cord-259237-aty0vrat	153	10	of	of	IN
cord-259237-aty0vrat	153	11	really	really	RB
cord-259237-aty0vrat	153	12	interesting	interesting	JJ
cord-259237-aty0vrat	153	13	new	new	JJ
cord-259237-aty0vrat	153	14	gene	gene	NN
cord-259237-aty0vrat	153	15	(	(	-LRB-
cord-259237-aty0vrat	153	16	RING)-finger	RING)-finger	NNP
cord-259237-aty0vrat	153	17	E3	E3	NNP
cord-259237-aty0vrat	153	18	ligase	ligase	NN
cord-259237-aty0vrat	153	19	complexes	complex	NNS
cord-259237-aty0vrat	153	20	,	,	,
cord-259237-aty0vrat	153	21	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	153	22	and	and	CC
cord-259237-aty0vrat	153	23	Doa10	Doa10	NNP
cord-259237-aty0vrat	153	24	,	,	,
cord-259237-aty0vrat	153	25	which	which	WDT
cord-259237-aty0vrat	153	26	mediate	mediate	VBP
cord-259237-aty0vrat	153	27	ERAD	ERAD	NNP
cord-259237-aty0vrat	153	28	by	by	IN
cord-259237-aty0vrat	153	29	targeting	target	VBG
cord-259237-aty0vrat	153	30	discrete	discrete	JJ
cord-259237-aty0vrat	153	31	substrates	substrate	NNS
cord-259237-aty0vrat	153	32	[	[	-LRB-
cord-259237-aty0vrat	153	33	63	63	CD
cord-259237-aty0vrat	153	34	]	]	-RRB-
cord-259237-aty0vrat	153	35	.	.	.
cord-259237-aty0vrat	154	1	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	154	2	was	be	VBD
cord-259237-aty0vrat	154	3	the	the	DT
cord-259237-aty0vrat	154	4	first	first	JJ
cord-259237-aty0vrat	154	5	E3	e3	NN
cord-259237-aty0vrat	154	6	enzyme	enzyme	NN
cord-259237-aty0vrat	154	7	identified	identify	VBN
cord-259237-aty0vrat	154	8	in	in	IN
cord-259237-aty0vrat	154	9	the	the	DT
cord-259237-aty0vrat	154	10	ERAD	ERAD	NNP
cord-259237-aty0vrat	154	11	pathway	pathway	NN
cord-259237-aty0vrat	154	12	during	during	IN
cord-259237-aty0vrat	154	13	the	the	DT
cord-259237-aty0vrat	154	14	study	study	NN
cord-259237-aty0vrat	154	15	of	of	IN
cord-259237-aty0vrat	154	16	HMG	HMG	NNP
cord-259237-aty0vrat	154	17	-	-	HYPH
cord-259237-aty0vrat	154	18	CoA	coa	NN
cord-259237-aty0vrat	154	19	reductase	reductase	NN
cord-259237-aty0vrat	154	20	degradation	degradation	NN
cord-259237-aty0vrat	154	21	(	(	-LRB-
cord-259237-aty0vrat	154	22	Hrd	Hrd	NNP
cord-259237-aty0vrat	154	23	)	)	-RRB-
cord-259237-aty0vrat	155	1	[	[	-LRB-
cord-259237-aty0vrat	155	2	64	64	CD
cord-259237-aty0vrat	155	3	]	]	-RRB-
cord-259237-aty0vrat	155	4	.	.	.
cord-259237-aty0vrat	156	1	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	156	2	has	have	VBZ
cord-259237-aty0vrat	156	3	6	6	CD
cord-259237-aty0vrat	156	4	transmembrane	transmembrane	NN
cord-259237-aty0vrat	156	5	helices	helix	NNS
cord-259237-aty0vrat	156	6	in	in	IN
cord-259237-aty0vrat	156	7	its	-PRON-	PRP$
cord-259237-aty0vrat	156	8	N	n	CD
cord-259237-aty0vrat	156	9	-	-	HYPH
cord-259237-aty0vrat	156	10	terminal	terminal	JJ
cord-259237-aty0vrat	156	11	transmembrane	transmembrane	NN
cord-259237-aty0vrat	156	12	domain	domain	NN
cord-259237-aty0vrat	156	13	and	and	CC
cord-259237-aty0vrat	156	14	a	a	DT
cord-259237-aty0vrat	156	15	catalytic	catalytic	JJ
cord-259237-aty0vrat	156	16	RING	ring	NN
cord-259237-aty0vrat	156	17	domain	domain	NN
cord-259237-aty0vrat	156	18	in	in	IN
cord-259237-aty0vrat	156	19	the	the	DT
cord-259237-aty0vrat	156	20	soluble	soluble	JJ
cord-259237-aty0vrat	156	21	C	c	NN
cord-259237-aty0vrat	156	22	-	-	HYPH
cord-259237-aty0vrat	156	23	terminal	terminal	NN
cord-259237-aty0vrat	156	24	region	region	NN
cord-259237-aty0vrat	156	25	extended	extend	VBN
cord-259237-aty0vrat	156	26	to	to	IN
cord-259237-aty0vrat	156	27	the	the	DT
cord-259237-aty0vrat	156	28	cytosol	cytosol	NN
cord-259237-aty0vrat	156	29	.	.	.
cord-259237-aty0vrat	157	1	Using	use	VBG
cord-259237-aty0vrat	157	2	an	an	DT
cord-259237-aty0vrat	157	3	elegant	elegant	JJ
cord-259237-aty0vrat	157	4	ERAD	ERAD	NNP
cord-259237-aty0vrat	157	5	assay	assay	NN
cord-259237-aty0vrat	157	6	reconstituted	reconstitute	VBN
cord-259237-aty0vrat	157	7	in	in	IN
cord-259237-aty0vrat	157	8	vitro	vitro	FW
cord-259237-aty0vrat	157	9	,	,	,
cord-259237-aty0vrat	157	10	the	the	DT
cord-259237-aty0vrat	157	11	Hrd1-mediated	hrd1-mediated	JJ
cord-259237-aty0vrat	157	12	formation	formation	NN
cord-259237-aty0vrat	157	13	of	of	IN
cord-259237-aty0vrat	157	14	ubiquitin	ubiquitin	RB
cord-259237-aty0vrat	157	15	-	-	HYPH
cord-259237-aty0vrat	157	16	gated	gate	VBN
cord-259237-aty0vrat	157	17	protein	protein	NN
cord-259237-aty0vrat	157	18	-	-	HYPH
cord-259237-aty0vrat	157	19	conducting	conduct	VBG
cord-259237-aty0vrat	157	20	membrane	membrane	NN
cord-259237-aty0vrat	157	21	channels	channel	NNS
cord-259237-aty0vrat	157	22	has	have	VBZ
cord-259237-aty0vrat	157	23	been	be	VBN
cord-259237-aty0vrat	157	24	demonstrated	demonstrate	VBN
cord-259237-aty0vrat	157	25	[	[	-LRB-
cord-259237-aty0vrat	157	26	65	65	CD
cord-259237-aty0vrat	157	27	,	,	,
cord-259237-aty0vrat	157	28	66	66	CD
cord-259237-aty0vrat	157	29	]	]	-RRB-
cord-259237-aty0vrat	157	30	.	.	.
cord-259237-aty0vrat	158	1	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	158	2	has	have	VBZ
cord-259237-aty0vrat	158	3	two	two	CD
cord-259237-aty0vrat	158	4	mammalian	mammalian	JJ
cord-259237-aty0vrat	158	5	orthologs	ortholog	NNS
cord-259237-aty0vrat	158	6	named	name	VBN
cord-259237-aty0vrat	158	7	HRD1	HRD1	NNP
cord-259237-aty0vrat	158	8	and	and	CC
cord-259237-aty0vrat	158	9	gp78	gp78	NNP
cord-259237-aty0vrat	158	10	,	,	,
cord-259237-aty0vrat	158	11	and	and	CC
cord-259237-aty0vrat	158	12	its	-PRON-	PRP$
cord-259237-aty0vrat	158	13	functioning	function	VBG
cord-259237-aty0vrat	158	14	E2	E2	NNP
cord-259237-aty0vrat	158	15	enzyme	enzyme	NN
cord-259237-aty0vrat	158	16	is	be	VBZ
cord-259237-aty0vrat	158	17	known	know	VBN
cord-259237-aty0vrat	158	18	as	as	IN
cord-259237-aty0vrat	158	19	Ubc7	Ubc7	NNP
cord-259237-aty0vrat	158	20	,	,	,
cord-259237-aty0vrat	158	21	which	which	WDT
cord-259237-aty0vrat	158	22	also	also	RB
cord-259237-aty0vrat	158	23	has	have	VBZ
cord-259237-aty0vrat	158	24	two	two	CD
cord-259237-aty0vrat	158	25	mammalian	mammalian	JJ
cord-259237-aty0vrat	158	26	orthologs	ortholog	NNS
cord-259237-aty0vrat	158	27	,	,	,
cord-259237-aty0vrat	158	28	Ube2g2	ube2g2	NN
cord-259237-aty0vrat	158	29	and	and	CC
cord-259237-aty0vrat	158	30	Ube2g1	ube2g1	JJ
cord-259237-aty0vrat	158	31	[	[	-LRB-
cord-259237-aty0vrat	158	32	67	67	CD
cord-259237-aty0vrat	158	33	]	]	-RRB-
cord-259237-aty0vrat	158	34	.	.	.
cord-259237-aty0vrat	159	1	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	159	2	is	be	VBZ
cord-259237-aty0vrat	159	3	unstable	unstable	JJ
cord-259237-aty0vrat	159	4	,	,	,
cord-259237-aty0vrat	159	5	and	and	CC
cord-259237-aty0vrat	159	6	must	must	MD
cord-259237-aty0vrat	159	7	be	be	VB
cord-259237-aty0vrat	159	8	stabilized	stabilize	VBN
cord-259237-aty0vrat	159	9	by	by	IN
cord-259237-aty0vrat	159	10	its	-PRON-	PRP$
cord-259237-aty0vrat	159	11	co	co	NN
cord-259237-aty0vrat	159	12	-	-	NN
cord-259237-aty0vrat	159	13	factor	factor	NN
cord-259237-aty0vrat	159	14	Hrd3	Hrd3	NNP
cord-259237-aty0vrat	159	15	in	in	IN
cord-259237-aty0vrat	159	16	an	an	DT
cord-259237-aty0vrat	159	17	equimolar	equimolar	JJ
cord-259237-aty0vrat	159	18	ratio	ratio	NN
cord-259237-aty0vrat	159	19	[	[	-LRB-
cord-259237-aty0vrat	159	20	68	68	CD
cord-259237-aty0vrat	159	21	]	]	-RRB-
cord-259237-aty0vrat	159	22	.	.	.
cord-259237-aty0vrat	160	1	The	the	DT
cord-259237-aty0vrat	160	2	mammalian	mammalian	JJ
cord-259237-aty0vrat	160	3	ortholog	ortholog	NN
cord-259237-aty0vrat	160	4	of	of	IN
cord-259237-aty0vrat	160	5	Hrd3	Hrd3	NNP
cord-259237-aty0vrat	160	6	is	be	VBZ
cord-259237-aty0vrat	160	7	SEL1L	sel1l	JJ
cord-259237-aty0vrat	160	8	,	,	,
cord-259237-aty0vrat	160	9	which	which	WDT
cord-259237-aty0vrat	160	10	is	be	VBZ
cord-259237-aty0vrat	160	11	required	require	VBN
cord-259237-aty0vrat	160	12	for	for	IN
cord-259237-aty0vrat	160	13	ERAD	ERAD	NNP
cord-259237-aty0vrat	160	14	substrate	substrate	NN
cord-259237-aty0vrat	160	15	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	160	16	[	[	-LRB-
cord-259237-aty0vrat	160	17	69	69	CD
cord-259237-aty0vrat	160	18	]	]	-RRB-
cord-259237-aty0vrat	160	19	.	.	.
cord-259237-aty0vrat	161	1	Hrd1	hrd1	NN
cord-259237-aty0vrat	161	2	interacts	interact	VBZ
cord-259237-aty0vrat	161	3	with	with	IN
cord-259237-aty0vrat	161	4	Der1	Der1	NNP
cord-259237-aty0vrat	161	5	,	,	,
cord-259237-aty0vrat	161	6	and	and	CC
cord-259237-aty0vrat	161	7	the	the	DT
cord-259237-aty0vrat	161	8	Der1-Hrd1	der1-hrd1	NN
cord-259237-aty0vrat	161	9	interaction	interaction	NN
cord-259237-aty0vrat	161	10	is	be	VBZ
cord-259237-aty0vrat	161	11	bridged	bridge	VBN
cord-259237-aty0vrat	161	12	by	by	IN
cord-259237-aty0vrat	161	13	another	another	DT
cord-259237-aty0vrat	161	14	integral	integral	JJ
cord-259237-aty0vrat	161	15	membrane	membrane	NN
cord-259237-aty0vrat	161	16	protein	protein	NN
cord-259237-aty0vrat	161	17	Usa1	Usa1	NNP
cord-259237-aty0vrat	161	18	,	,	,
cord-259237-aty0vrat	161	19	which	which	WDT
cord-259237-aty0vrat	161	20	is	be	VBZ
cord-259237-aty0vrat	161	21	also	also	RB
cord-259237-aty0vrat	161	22	required	require	VBN
cord-259237-aty0vrat	161	23	for	for	IN
cord-259237-aty0vrat	161	24	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	161	25	oligomerization	oligomerization	NN
cord-259237-aty0vrat	161	26	[	[	-LRB-
cord-259237-aty0vrat	161	27	70	70	CD
cord-259237-aty0vrat	161	28	]	]	-RRB-
cord-259237-aty0vrat	161	29	.	.	.
cord-259237-aty0vrat	162	1	The	the	DT
cord-259237-aty0vrat	162	2	Usa1	Usa1	NNP
cord-259237-aty0vrat	162	3	mammalian	mammalian	JJ
cord-259237-aty0vrat	162	4	ortholog	ortholog	NN
cord-259237-aty0vrat	162	5	is	be	VBZ
cord-259237-aty0vrat	162	6	called	call	VBN
cord-259237-aty0vrat	162	7	Herp	Herp	NNP
cord-259237-aty0vrat	162	8	,	,	,
cord-259237-aty0vrat	162	9	which	which	WDT
cord-259237-aty0vrat	162	10	also	also	RB
cord-259237-aty0vrat	162	11	interacts	interact	VBZ
cord-259237-aty0vrat	162	12	with	with	IN
cord-259237-aty0vrat	162	13	HRD1	HRD1	NNP
cord-259237-aty0vrat	162	14	and	and	CC
cord-259237-aty0vrat	162	15	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	162	16	and	and	CC
cord-259237-aty0vrat	162	17	plays	play	VBZ
cord-259237-aty0vrat	162	18	an	an	DT
cord-259237-aty0vrat	162	19	important	important	JJ
cord-259237-aty0vrat	162	20	role	role	NN
cord-259237-aty0vrat	162	21	in	in	IN
cord-259237-aty0vrat	162	22	ERAD	ERAD	NNP
cord-259237-aty0vrat	162	23	[	[	-LRB-
cord-259237-aty0vrat	162	24	71	71	CD
cord-259237-aty0vrat	162	25	]	]	-RRB-
cord-259237-aty0vrat	162	26	.	.	.
cord-259237-aty0vrat	163	1	Doa10	Doa10	NNP
cord-259237-aty0vrat	163	2	was	be	VBD
cord-259237-aty0vrat	163	3	identified	identify	VBN
cord-259237-aty0vrat	163	4	in	in	IN
cord-259237-aty0vrat	163	5	degradation	degradation	NN
cord-259237-aty0vrat	163	6	studies	study	NNS
cord-259237-aty0vrat	163	7	of	of	IN
cord-259237-aty0vrat	163	8	Mating	Mating	NNP
cord-259237-aty0vrat	163	9	Type	Type	NNP
cord-259237-aty0vrat	163	10	(	(	-LRB-
cord-259237-aty0vrat	163	11	MAT)-α2	MAT)-α2	NNP
cord-259237-aty0vrat	163	12	-	-	SYM
cord-259237-aty0vrat	163	13	10	10	NNP
cord-259237-aty0vrat	163	14	(	(	-LRB-
cord-259237-aty0vrat	163	15	doa	doa	NNP
cord-259237-aty0vrat	163	16	)	)	-RRB-
cord-259237-aty0vrat	163	17	,	,	,
cord-259237-aty0vrat	163	18	which	which	WDT
cord-259237-aty0vrat	163	19	is	be	VBZ
cord-259237-aty0vrat	163	20	a	a	DT
cord-259237-aty0vrat	163	21	yeast	yeast	NN
cord-259237-aty0vrat	163	22	transcription	transcription	NN
cord-259237-aty0vrat	163	23	factor	factor	NN
cord-259237-aty0vrat	163	24	.	.	.
cord-259237-aty0vrat	164	1	Doa10	Doa10	NNP
cord-259237-aty0vrat	164	2	is	be	VBZ
cord-259237-aty0vrat	164	3	a~150	a~150	CD
cord-259237-aty0vrat	164	4	kDa	kda	NN
cord-259237-aty0vrat	164	5	protein	protein	NN
cord-259237-aty0vrat	164	6	that	that	WDT
cord-259237-aty0vrat	164	7	has	have	VBZ
cord-259237-aty0vrat	164	8	14	14	CD
cord-259237-aty0vrat	164	9	transmembrane	transmembrane	NN
cord-259237-aty0vrat	164	10	domains	domain	NNS
cord-259237-aty0vrat	164	11	,	,	,
cord-259237-aty0vrat	164	12	which	which	WDT
cord-259237-aty0vrat	164	13	requires	require	VBZ
cord-259237-aty0vrat	164	14	both	both	DT
cord-259237-aty0vrat	164	15	Ubc6	Ubc6	NNP
cord-259237-aty0vrat	164	16	and	and	CC
cord-259237-aty0vrat	164	17	Ubc7	Ubc7	NNP
cord-259237-aty0vrat	164	18	as	as	IN
cord-259237-aty0vrat	164	19	E2	E2	NNP
cord-259237-aty0vrat	164	20	enzymes	enzyme	NNS
cord-259237-aty0vrat	164	21	.	.	.
cord-259237-aty0vrat	165	1	The	the	DT
cord-259237-aty0vrat	165	2	Doa10	Doa10	NNP
cord-259237-aty0vrat	165	3	mammalian	mammalian	JJ
cord-259237-aty0vrat	165	4	ortholog	ortholog	NN
cord-259237-aty0vrat	165	5	is	be	VBZ
cord-259237-aty0vrat	165	6	TEB4	TEB4	NNP
cord-259237-aty0vrat	165	7	(	(	-LRB-
cord-259237-aty0vrat	165	8	MARCH6	MARCH6	NNP
cord-259237-aty0vrat	165	9	)	)	-RRB-
cord-259237-aty0vrat	165	10	,	,	,
cord-259237-aty0vrat	165	11	which	which	WDT
cord-259237-aty0vrat	165	12	functions	function	VBZ
cord-259237-aty0vrat	165	13	in	in	IN
cord-259237-aty0vrat	165	14	the	the	DT
cord-259237-aty0vrat	165	15	ERAD	ERAD	NNP
cord-259237-aty0vrat	165	16	pathway	pathway	NN
cord-259237-aty0vrat	165	17	with	with	IN
cord-259237-aty0vrat	165	18	similar	similar	JJ
cord-259237-aty0vrat	165	19	subcellular	subcellular	JJ
cord-259237-aty0vrat	165	20	distribution	distribution	NN
cord-259237-aty0vrat	165	21	and	and	CC
cord-259237-aty0vrat	165	22	topology	topology	NN
cord-259237-aty0vrat	165	23	[	[	-LRB-
cord-259237-aty0vrat	165	24	72	72	CD
cord-259237-aty0vrat	165	25	]	]	-RRB-
cord-259237-aty0vrat	165	26	.	.	.
cord-259237-aty0vrat	166	1	The	the	DT
cord-259237-aty0vrat	166	2	Ubc6	Ubc6	NNP
cord-259237-aty0vrat	166	3	E2	E2	NNP
cord-259237-aty0vrat	166	4	enzyme	enzyme	NN
cord-259237-aty0vrat	166	5	has	have	VBZ
cord-259237-aty0vrat	166	6	two	two	CD
cord-259237-aty0vrat	166	7	mammalian	mammalian	JJ
cord-259237-aty0vrat	166	8	orthologs	ortholog	NNS
cord-259237-aty0vrat	166	9	,	,	,
cord-259237-aty0vrat	166	10	Ube2j1	ube2j1	CD
cord-259237-aty0vrat	166	11	and	and	CC
cord-259237-aty0vrat	166	12	Ube2j2	ube2j2	RB
cord-259237-aty0vrat	166	13	;	;	:
cord-259237-aty0vrat	166	14	both	both	DT
cord-259237-aty0vrat	166	15	are	be	VBP
cord-259237-aty0vrat	166	16	involved	involve	VBN
cord-259237-aty0vrat	166	17	in	in	IN
cord-259237-aty0vrat	166	18	ERAD	ERAD	NNP
cord-259237-aty0vrat	166	19	[	[	-LRB-
cord-259237-aty0vrat	166	20	73	73	CD
cord-259237-aty0vrat	166	21	,	,	,
cord-259237-aty0vrat	166	22	74	74	CD
cord-259237-aty0vrat	166	23	]	]	-RRB-
cord-259237-aty0vrat	166	24	.	.	.
cord-259237-aty0vrat	167	1	In	in	IN
cord-259237-aty0vrat	167	2	Saccharomyces	saccharomyce	NNS
cord-259237-aty0vrat	167	3	cerevisiae	cerevisiae	NNS
cord-259237-aty0vrat	167	4	,	,	,
cord-259237-aty0vrat	167	5	ERAD	ERAD	NNP
cord-259237-aty0vrat	167	6	is	be	VBZ
cord-259237-aty0vrat	167	7	executed	execute	VBN
cord-259237-aty0vrat	167	8	synergistically	synergistically	RB
cord-259237-aty0vrat	167	9	by	by	IN
cord-259237-aty0vrat	167	10	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	167	11	and	and	CC
cord-259237-aty0vrat	167	12	Doa10	Doa10	NNP
cord-259237-aty0vrat	167	13	with	with	IN
cord-259237-aty0vrat	167	14	minimal	minimal	JJ
cord-259237-aty0vrat	167	15	redundancy	redundancy	NN
cord-259237-aty0vrat	167	16	because	because	IN
cord-259237-aty0vrat	167	17	they	-PRON-	PRP
cord-259237-aty0vrat	167	18	exhibit	exhibit	VBP
cord-259237-aty0vrat	167	19	different	different	JJ
cord-259237-aty0vrat	167	20	substrate	substrate	NN
cord-259237-aty0vrat	167	21	specificity	specificity	NN
cord-259237-aty0vrat	167	22	.	.	.
cord-259237-aty0vrat	168	1	Doa10	Doa10	NNP
cord-259237-aty0vrat	168	2	mainly	mainly	RB
cord-259237-aty0vrat	168	3	triggers	trigger	VBZ
cord-259237-aty0vrat	168	4	ubiquitylation	ubiquitylation	NN
cord-259237-aty0vrat	168	5	of	of	IN
cord-259237-aty0vrat	168	6	specific	specific	JJ
cord-259237-aty0vrat	168	7	soluble	soluble	JJ
cord-259237-aty0vrat	168	8	proteins	protein	NNS
cord-259237-aty0vrat	168	9	and	and	CC
cord-259237-aty0vrat	168	10	membrane	membrane	NN
cord-259237-aty0vrat	168	11	proteins	protein	NNS
cord-259237-aty0vrat	168	12	with	with	IN
cord-259237-aty0vrat	168	13	degrons	degron	NNS
cord-259237-aty0vrat	168	14	exposed	expose	VBN
cord-259237-aty0vrat	168	15	to	to	IN
cord-259237-aty0vrat	168	16	the	the	DT
cord-259237-aty0vrat	168	17	cytosol	cytosol	NN
cord-259237-aty0vrat	168	18	;	;	:
cord-259237-aty0vrat	168	19	a	a	DT
cord-259237-aty0vrat	168	20	process	process	NN
cord-259237-aty0vrat	168	21	referred	refer	VBN
cord-259237-aty0vrat	168	22	to	to	IN
cord-259237-aty0vrat	168	23	as	as	IN
cord-259237-aty0vrat	168	24	ERAD	ERAD	NNP
cord-259237-aty0vrat	168	25	-	-	HYPH
cord-259237-aty0vrat	168	26	C	C	NNP
cord-259237-aty0vrat	168	27	[	[	-LRB-
cord-259237-aty0vrat	168	28	75	75	CD
cord-259237-aty0vrat	168	29	,	,	,
cord-259237-aty0vrat	168	30	76	76	CD
cord-259237-aty0vrat	168	31	]	]	-RRB-
cord-259237-aty0vrat	168	32	.	.	.
cord-259237-aty0vrat	169	1	Hrd1	Hrd1	NNP
cord-259237-aty0vrat	169	2	interacts	interact	VBZ
cord-259237-aty0vrat	169	3	with	with	IN
cord-259237-aty0vrat	169	4	two	two	CD
cord-259237-aty0vrat	169	5	other	other	JJ
cord-259237-aty0vrat	169	6	types	type	NNS
cord-259237-aty0vrat	169	7	of	of	IN
cord-259237-aty0vrat	169	8	substrates	substrate	NNS
cord-259237-aty0vrat	169	9	,	,	,
cord-259237-aty0vrat	169	10	whose	whose	WP$
cord-259237-aty0vrat	169	11	degradation	degradation	NN
cord-259237-aty0vrat	169	12	is	be	VBZ
cord-259237-aty0vrat	169	13	termed	term	VBN
cord-259237-aty0vrat	169	14	ERAD	ERAD	NNP
cord-259237-aty0vrat	169	15	-	-	HYPH
cord-259237-aty0vrat	169	16	L	L	NNP
cord-259237-aty0vrat	169	17	and	and	CC
cord-259237-aty0vrat	169	18	ERAD	ERAD	NNP
cord-259237-aty0vrat	169	19	-	-	HYPH
cord-259237-aty0vrat	169	20	M.	M.	NNP
cord-259237-aty0vrat	169	21	ERAD	ERAD	NNP
cord-259237-aty0vrat	169	22	-	-	HYPH
cord-259237-aty0vrat	169	23	L	L	NNP
cord-259237-aty0vrat	169	24	includes	include	VBZ
cord-259237-aty0vrat	169	25	soluble	soluble	JJ
cord-259237-aty0vrat	169	26	lumenal	lumenal	JJ
cord-259237-aty0vrat	169	27	proteins	protein	NNS
cord-259237-aty0vrat	169	28	in	in	IN
cord-259237-aty0vrat	169	29	the	the	DT
cord-259237-aty0vrat	169	30	ER	er	NN
cord-259237-aty0vrat	169	31	and	and	CC
cord-259237-aty0vrat	169	32	transmembrane	transmembrane	NN
cord-259237-aty0vrat	169	33	proteins	protein	NNS
cord-259237-aty0vrat	169	34	with	with	IN
cord-259237-aty0vrat	169	35	degrons	degron	NNS
cord-259237-aty0vrat	169	36	exposed	expose	VBN
cord-259237-aty0vrat	169	37	to	to	IN
cord-259237-aty0vrat	169	38	the	the	DT
cord-259237-aty0vrat	169	39	ER	ER	NNP
cord-259237-aty0vrat	169	40	lumen	lumen	NN
cord-259237-aty0vrat	169	41	;	;	:
cord-259237-aty0vrat	169	42	ERAD	ERAD	NNP
cord-259237-aty0vrat	169	43	-	-	HYPH
cord-259237-aty0vrat	169	44	M	M	NNP
cord-259237-aty0vrat	169	45	includes	include	VBZ
cord-259237-aty0vrat	169	46	transmembrane	transmembrane	NN
cord-259237-aty0vrat	169	47	proteins	protein	NNS
cord-259237-aty0vrat	169	48	with	with	IN
cord-259237-aty0vrat	169	49	degrons	degron	NNS
cord-259237-aty0vrat	169	50	embedded	embed	VBN
cord-259237-aty0vrat	169	51	into	into	IN
cord-259237-aty0vrat	169	52	the	the	DT
cord-259237-aty0vrat	169	53	ER	ER	NNP
cord-259237-aty0vrat	169	54	membrane	membrane	NN
cord-259237-aty0vrat	169	55	[	[	-LRB-
cord-259237-aty0vrat	169	56	63	63	CD
cord-259237-aty0vrat	169	57	]	]	-RRB-
cord-259237-aty0vrat	169	58	.	.	.
cord-259237-aty0vrat	170	1	Simultaneous	simultaneous	JJ
cord-259237-aty0vrat	170	2	inactivation	inactivation	NN
cord-259237-aty0vrat	170	3	of	of	IN
cord-259237-aty0vrat	170	4	both	both	DT
cord-259237-aty0vrat	170	5	genes	gene	NNS
cord-259237-aty0vrat	170	6	has	have	VBZ
cord-259237-aty0vrat	170	7	been	be	VBN
cord-259237-aty0vrat	170	8	shown	show	VBN
cord-259237-aty0vrat	170	9	to	to	TO
cord-259237-aty0vrat	170	10	increase	increase	VB
cord-259237-aty0vrat	170	11	the	the	DT
cord-259237-aty0vrat	170	12	sensitivity	sensitivity	NN
cord-259237-aty0vrat	170	13	to	to	IN
cord-259237-aty0vrat	170	14	heavy	heavy	JJ
cord-259237-aty0vrat	170	15	metal	metal	NN
cord-259237-aty0vrat	170	16	-	-	HYPH
cord-259237-aty0vrat	170	17	induced	induce	VBN
cord-259237-aty0vrat	170	18	cellular	cellular	JJ
cord-259237-aty0vrat	170	19	stress	stress	NN
cord-259237-aty0vrat	170	20	and	and	CC
cord-259237-aty0vrat	170	21	exhibit	exhibit	VB
cord-259237-aty0vrat	170	22	an	an	DT
cord-259237-aty0vrat	170	23	elevated	elevated	JJ
cord-259237-aty0vrat	170	24	UPR	upr	NN
cord-259237-aty0vrat	170	25	.	.	.
cord-259237-aty0vrat	171	1	The	the	DT
cord-259237-aty0vrat	171	2	regulation	regulation	NN
cord-259237-aty0vrat	171	3	of	of	IN
cord-259237-aty0vrat	171	4	protein	protein	NN
cord-259237-aty0vrat	171	5	folding	folding	NN
cord-259237-aty0vrat	171	6	and	and	CC
cord-259237-aty0vrat	171	7	the	the	DT
cord-259237-aty0vrat	171	8	functional	functional	JJ
cord-259237-aty0vrat	171	9	relation	relation	NN
cord-259237-aty0vrat	171	10	between	between	IN
cord-259237-aty0vrat	171	11	ERAD	ERAD	NNP
cord-259237-aty0vrat	171	12	and	and	CC
cord-259237-aty0vrat	171	13	the	the	DT
cord-259237-aty0vrat	171	14	UPR	UPR	NNP
cord-259237-aty0vrat	171	15	are	be	VBP
cord-259237-aty0vrat	171	16	much	much	RB
cord-259237-aty0vrat	171	17	more	more	RBR
cord-259237-aty0vrat	171	18	complex	complex	JJ
cord-259237-aty0vrat	171	19	in	in	IN
cord-259237-aty0vrat	171	20	mammalian	mammalian	JJ
cord-259237-aty0vrat	171	21	cells	cell	NNS
cord-259237-aty0vrat	171	22	.	.	.
cord-259237-aty0vrat	172	1	In	in	IN
cord-259237-aty0vrat	172	2	Saccharomyces	Saccharomyces	NNP
cord-259237-aty0vrat	172	3	cerevisiae	cerevisiae	NNS
cord-259237-aty0vrat	172	4	,	,	,
cord-259237-aty0vrat	172	5	the	the	DT
cord-259237-aty0vrat	172	6	CNX	CNX	NNP
cord-259237-aty0vrat	172	7	cycle	cycle	NN
cord-259237-aty0vrat	172	8	does	do	VBZ
cord-259237-aty0vrat	172	9	not	not	RB
cord-259237-aty0vrat	172	10	exist	exist	VB
cord-259237-aty0vrat	172	11	due	due	JJ
cord-259237-aty0vrat	172	12	to	to	IN
cord-259237-aty0vrat	172	13	the	the	DT
cord-259237-aty0vrat	172	14	lack	lack	NN
cord-259237-aty0vrat	172	15	of	of	IN
cord-259237-aty0vrat	172	16	UGGT	UGGT	NNP
cord-259237-aty0vrat	172	17	.	.	.
cord-259237-aty0vrat	173	1	In	in	IN
cord-259237-aty0vrat	173	2	addition	addition	NN
cord-259237-aty0vrat	173	3	,	,	,
cord-259237-aty0vrat	173	4	protein	protein	NN
cord-259237-aty0vrat	173	5	synthesis	synthesis	NN
cord-259237-aty0vrat	173	6	is	be	VBZ
cord-259237-aty0vrat	173	7	tightly	tightly	RB
cord-259237-aty0vrat	173	8	controlled	control	VBN
cord-259237-aty0vrat	173	9	at	at	IN
cord-259237-aty0vrat	173	10	the	the	DT
cord-259237-aty0vrat	173	11	translational	translational	JJ
cord-259237-aty0vrat	173	12	level	level	NN
cord-259237-aty0vrat	173	13	by	by	IN
cord-259237-aty0vrat	173	14	determination	determination	NN
cord-259237-aty0vrat	173	15	of	of	IN
cord-259237-aty0vrat	173	16	the	the	DT
cord-259237-aty0vrat	173	17	stoichiometry	stoichiometry	NN
cord-259237-aty0vrat	173	18	to	to	TO
cord-259237-aty0vrat	173	19	avoid	avoid	VB
cord-259237-aty0vrat	173	20	surplus	surplus	JJ
cord-259237-aty0vrat	173	21	production	production	NN
cord-259237-aty0vrat	173	22	,	,	,
cord-259237-aty0vrat	173	23	resulting	result	VBG
cord-259237-aty0vrat	173	24	in	in	IN
cord-259237-aty0vrat	173	25	minimal	minimal	JJ
cord-259237-aty0vrat	173	26	dependence	dependence	NN
cord-259237-aty0vrat	173	27	on	on	IN
cord-259237-aty0vrat	173	28	the	the	DT
cord-259237-aty0vrat	173	29	post	post	JJ
cord-259237-aty0vrat	173	30	-	-	JJ
cord-259237-aty0vrat	173	31	translational	translational	JJ
cord-259237-aty0vrat	173	32	regulation	regulation	NN
cord-259237-aty0vrat	173	33	of	of	IN
cord-259237-aty0vrat	173	34	protein	protein	NN
cord-259237-aty0vrat	173	35	expression	expression	NN
cord-259237-aty0vrat	173	36	.	.	.
cord-259237-aty0vrat	174	1	Moreover	moreover	RB
cord-259237-aty0vrat	174	2	,	,	,
cord-259237-aty0vrat	174	3	although	although	IN
cord-259237-aty0vrat	174	4	the	the	DT
cord-259237-aty0vrat	174	5	yeast	yeast	NN
cord-259237-aty0vrat	174	6	ERManI	ERManI	NNP
cord-259237-aty0vrat	174	7	ortholog	ortholog	NN
cord-259237-aty0vrat	174	8	Mns1p	Mns1p	NNP
cord-259237-aty0vrat	174	9	and	and	CC
cord-259237-aty0vrat	174	10	EDEM	EDEM	NNP
cord-259237-aty0vrat	174	11	ortholog	ortholog	NN
cord-259237-aty0vrat	174	12	Htm1p	Htm1p	NNP
cord-259237-aty0vrat	174	13	are	be	VBP
cord-259237-aty0vrat	174	14	indispensable	indispensable	JJ
cord-259237-aty0vrat	174	15	for	for	IN
cord-259237-aty0vrat	174	16	ERAD	ERAD	NNP
cord-259237-aty0vrat	174	17	,	,	,
cord-259237-aty0vrat	174	18	only	only	RB
cord-259237-aty0vrat	174	19	one	one	CD
cord-259237-aty0vrat	174	20	EDEM	EDEM	NNP
cord-259237-aty0vrat	174	21	ortholog	ortholog	NN
cord-259237-aty0vrat	174	22	is	be	VBZ
cord-259237-aty0vrat	174	23	present	present	JJ
cord-259237-aty0vrat	174	24	in	in	IN
cord-259237-aty0vrat	174	25	yeast	yeast	NN
cord-259237-aty0vrat	174	26	[	[	-LRB-
cord-259237-aty0vrat	174	27	77	77	CD
cord-259237-aty0vrat	174	28	,	,	,
cord-259237-aty0vrat	174	29	78	78	CD
cord-259237-aty0vrat	174	30	]	]	-RRB-
cord-259237-aty0vrat	174	31	.	.	.
cord-259237-aty0vrat	175	1	Because	because	IN
cord-259237-aty0vrat	175	2	overly	overly	RB
cord-259237-aty0vrat	175	3	active	active	JJ
cord-259237-aty0vrat	175	4	ERAD	ERAD	NNP
cord-259237-aty0vrat	175	5	may	may	MD
cord-259237-aty0vrat	175	6	interfere	interfere	VB
cord-259237-aty0vrat	175	7	with	with	IN
cord-259237-aty0vrat	175	8	the	the	DT
cord-259237-aty0vrat	175	9	regular	regular	JJ
cord-259237-aty0vrat	175	10	protein	protein	NN
cord-259237-aty0vrat	175	11	folding	folding	NN
cord-259237-aty0vrat	175	12	process	process	NN
cord-259237-aty0vrat	175	13	in	in	IN
cord-259237-aty0vrat	175	14	the	the	DT
cord-259237-aty0vrat	175	15	ER	ER	NNP
cord-259237-aty0vrat	175	16	,	,	,
cord-259237-aty0vrat	175	17	mammalian	mammalian	JJ
cord-259237-aty0vrat	175	18	cells	cell	NNS
cord-259237-aty0vrat	175	19	have	have	VBP
cord-259237-aty0vrat	175	20	evolved	evolve	VBN
cord-259237-aty0vrat	175	21	mechanisms	mechanism	NNS
cord-259237-aty0vrat	175	22	to	to	TO
cord-259237-aty0vrat	175	23	tightly	tightly	RB
cord-259237-aty0vrat	175	24	regulate	regulate	VB
cord-259237-aty0vrat	175	25	this	this	DT
cord-259237-aty0vrat	175	26	quality	quality	NN
cord-259237-aty0vrat	175	27	control	control	NN
cord-259237-aty0vrat	175	28	device	device	NN
cord-259237-aty0vrat	175	29	by	by	IN
cord-259237-aty0vrat	175	30	a	a	DT
cord-259237-aty0vrat	175	31	combination	combination	NN
cord-259237-aty0vrat	175	32	of	of	IN
cord-259237-aty0vrat	175	33	compartmentalization	compartmentalization	NN
cord-259237-aty0vrat	175	34	and	and	CC
cord-259237-aty0vrat	175	35	tuning	tuning	NN
cord-259237-aty0vrat	175	36	.	.	.
cord-259237-aty0vrat	176	1	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	176	2	is	be	VBZ
cord-259237-aty0vrat	176	3	segregated	segregate	VBN
cord-259237-aty0vrat	176	4	into	into	IN
cord-259237-aty0vrat	176	5	ER	er	NN
cord-259237-aty0vrat	176	6	-	-	HYPH
cord-259237-aty0vrat	176	7	derived	derive	VBN
cord-259237-aty0vrat	176	8	,	,	,
cord-259237-aty0vrat	176	9	LC3-I	LC3-I	NNP
cord-259237-aty0vrat	176	10	-	-	HYPH
cord-259237-aty0vrat	176	11	associated	associate	VBN
cord-259237-aty0vrat	176	12	vesicles	vesicle	NNS
cord-259237-aty0vrat	176	13	,	,	,
cord-259237-aty0vrat	176	14	which	which	WDT
cord-259237-aty0vrat	176	15	are	be	VBP
cord-259237-aty0vrat	176	16	called	call	VBN
cord-259237-aty0vrat	176	17	EDEMosomes	EDEMosomes	NNP
cord-259237-aty0vrat	176	18	,	,	,
cord-259237-aty0vrat	176	19	where	where	WRB
cord-259237-aty0vrat	176	20	EDEM1	edem1	NN
cord-259237-aty0vrat	176	21	,	,	,
cord-259237-aty0vrat	176	22	OS-9	OS-9	NNP
cord-259237-aty0vrat	176	23	,	,	,
cord-259237-aty0vrat	176	24	and	and	CC
cord-259237-aty0vrat	176	25	SEL1L	SEL1L	NNP
cord-259237-aty0vrat	176	26	are	be	VBP
cord-259237-aty0vrat	176	27	concentrated	concentrate	VBN
cord-259237-aty0vrat	176	28	when	when	WRB
cord-259237-aty0vrat	176	29	they	-PRON-	PRP
cord-259237-aty0vrat	176	30	lack	lack	VBP
cord-259237-aty0vrat	176	31	client	client	NN
cord-259237-aty0vrat	176	32	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	176	33	to	to	TO
cord-259237-aty0vrat	176	34	dislocate	dislocate	VB
cord-259237-aty0vrat	176	35	(	(	-LRB-
cord-259237-aty0vrat	176	36	Figure	figure	NN
cord-259237-aty0vrat	176	37	1B	1b	CD
cord-259237-aty0vrat	176	38	)	)	-RRB-
cord-259237-aty0vrat	176	39	[	[	-LRB-
cord-259237-aty0vrat	176	40	79	79	CD
cord-259237-aty0vrat	176	41	]	]	-RRB-
cord-259237-aty0vrat	176	42	.	.	.
cord-259237-aty0vrat	177	1	Notably	notably	RB
cord-259237-aty0vrat	177	2	,	,	,
cord-259237-aty0vrat	177	3	unlike	unlike	IN
cord-259237-aty0vrat	177	4	chaperones	chaperone	NNS
cord-259237-aty0vrat	177	5	and	and	CC
cord-259237-aty0vrat	177	6	the	the	DT
cord-259237-aty0vrat	177	7	other	other	JJ
cord-259237-aty0vrat	177	8	enzymes	enzyme	NNS
cord-259237-aty0vrat	177	9	,	,	,
cord-259237-aty0vrat	177	10	many	many	JJ
cord-259237-aty0vrat	177	11	ERAD	ERAD	NNP
cord-259237-aty0vrat	177	12	regulators	regulator	NNS
cord-259237-aty0vrat	177	13	including	include	VBG
cord-259237-aty0vrat	177	14	ERManI	ERManI	NNP
cord-259237-aty0vrat	177	15	,	,	,
cord-259237-aty0vrat	177	16	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	177	17	,	,	,
cord-259237-aty0vrat	177	18	OS-9	OS-9	NNP
cord-259237-aty0vrat	177	19	,	,	,
cord-259237-aty0vrat	177	20	HERP	HERP	NNP
cord-259237-aty0vrat	177	21	,	,	,
cord-259237-aty0vrat	177	22	and	and	CC
cord-259237-aty0vrat	177	23	SEL1L	SEL1L	NNS
cord-259237-aty0vrat	177	24	are	be	VBP
cord-259237-aty0vrat	177	25	short	short	RB
cord-259237-aty0vrat	177	26	-	-	HYPH
cord-259237-aty0vrat	177	27	lived	live	VBN
cord-259237-aty0vrat	177	28	proteins	protein	NNS
cord-259237-aty0vrat	177	29	,	,	,
cord-259237-aty0vrat	177	30	and	and	CC
cord-259237-aty0vrat	177	31	ERManI	ERManI	NNP
cord-259237-aty0vrat	177	32	,	,	,
cord-259237-aty0vrat	177	33	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	177	34	,	,	,
cord-259237-aty0vrat	177	35	SEL1L	sel1l	JJ
cord-259237-aty0vrat	177	36	,	,	,
cord-259237-aty0vrat	177	37	and	and	CC
cord-259237-aty0vrat	177	38	OS-9	OS-9	NNP
cord-259237-aty0vrat	177	39	are	be	VBP
cord-259237-aty0vrat	177	40	targeted	target	VBN
cord-259237-aty0vrat	177	41	to	to	IN
cord-259237-aty0vrat	177	42	the	the	DT
cord-259237-aty0vrat	177	43	lysosomal	lysosomal	JJ
cord-259237-aty0vrat	177	44	pathway	pathway	NN
cord-259237-aty0vrat	177	45	for	for	IN
cord-259237-aty0vrat	177	46	degradation	degradation	NN
cord-259237-aty0vrat	177	47	[	[	-LRB-
cord-259237-aty0vrat	177	48	79	79	CD
cord-259237-aty0vrat	177	49	,	,	,
cord-259237-aty0vrat	177	50	80	80	CD
cord-259237-aty0vrat	177	51	]	]	-RRB-
cord-259237-aty0vrat	177	52	.	.	.
cord-259237-aty0vrat	178	1	Thus	thus	RB
cord-259237-aty0vrat	178	2	,	,	,
cord-259237-aty0vrat	178	3	EDEMosomes	edemosome	NNS
cord-259237-aty0vrat	178	4	are	be	VBP
cord-259237-aty0vrat	178	5	called	call	VBN
cord-259237-aty0vrat	178	6	ERAD	ERAD	NNP
cord-259237-aty0vrat	178	7	tuning	tuning	NN
cord-259237-aty0vrat	178	8	vesicles	vesicle	NNS
cord-259237-aty0vrat	178	9	,	,	,
cord-259237-aty0vrat	178	10	which	which	WDT
cord-259237-aty0vrat	178	11	deliver	deliver	VBP
cord-259237-aty0vrat	178	12	their	-PRON-	PRP$
cord-259237-aty0vrat	178	13	content	content	NN
cord-259237-aty0vrat	178	14	to	to	IN
cord-259237-aty0vrat	178	15	lysosomes	lysosome	NNS
cord-259237-aty0vrat	178	16	for	for	IN
cord-259237-aty0vrat	178	17	disposal	disposal	NN
cord-259237-aty0vrat	178	18	via	via	IN
cord-259237-aty0vrat	178	19	an	an	DT
cord-259237-aty0vrat	178	20	autophagy	autophagy	NN
cord-259237-aty0vrat	178	21	-	-	HYPH
cord-259237-aty0vrat	178	22	like	like	JJ
cord-259237-aty0vrat	178	23	pathway	pathway	NN
cord-259237-aty0vrat	178	24	to	to	TO
cord-259237-aty0vrat	178	25	reduce	reduce	VB
cord-259237-aty0vrat	178	26	the	the	DT
cord-259237-aty0vrat	178	27	ERAD	ERAD	NNP
cord-259237-aty0vrat	178	28	capacity	capacity	NN
cord-259237-aty0vrat	178	29	under	under	IN
cord-259237-aty0vrat	178	30	natural	natural	JJ
cord-259237-aty0vrat	178	31	conditions	condition	NNS
cord-259237-aty0vrat	178	32	[	[	-LRB-
cord-259237-aty0vrat	178	33	81	81	CD
cord-259237-aty0vrat	178	34	]	]	-RRB-
cord-259237-aty0vrat	178	35	.	.	.
cord-259237-aty0vrat	179	1	Additionally	additionally	RB
cord-259237-aty0vrat	179	2	,	,	,
cord-259237-aty0vrat	179	3	lysosomal	lysosomal	JJ
cord-259237-aty0vrat	179	4	inhibitors	inhibitor	NNS
cord-259237-aty0vrat	179	5	are	be	VBP
cord-259237-aty0vrat	179	6	able	able	JJ
cord-259237-aty0vrat	179	7	to	to	TO
cord-259237-aty0vrat	179	8	cause	cause	VB
cord-259237-aty0vrat	179	9	the	the	DT
cord-259237-aty0vrat	179	10	accumulation	accumulation	NN
cord-259237-aty0vrat	179	11	of	of	IN
cord-259237-aty0vrat	179	12	an	an	DT
cord-259237-aty0vrat	179	13	aggregating	aggregate	VBG
cord-259237-aty0vrat	179	14	mutant	mutant	NN
cord-259237-aty0vrat	179	15	of	of	IN
cord-259237-aty0vrat	179	16	dysferlin	dysferlin	NNP
cord-259237-aty0vrat	179	17	in	in	IN
cord-259237-aty0vrat	179	18	the	the	DT
cord-259237-aty0vrat	179	19	ER	er	NN
cord-259237-aty0vrat	179	20	when	when	WRB
cord-259237-aty0vrat	179	21	compared	compare	VBN
cord-259237-aty0vrat	179	22	to	to	IN
cord-259237-aty0vrat	179	23	the	the	DT
cord-259237-aty0vrat	179	24	wild	wild	JJ
cord-259237-aty0vrat	179	25	-	-	HYPH
cord-259237-aty0vrat	179	26	type	type	NN
cord-259237-aty0vrat	179	27	,	,	,
cord-259237-aty0vrat	179	28	which	which	WDT
cord-259237-aty0vrat	179	29	was	be	VBD
cord-259237-aty0vrat	179	30	used	use	VBN
cord-259237-aty0vrat	179	31	as	as	IN
cord-259237-aty0vrat	179	32	evidence	evidence	NN
cord-259237-aty0vrat	179	33	to	to	TO
cord-259237-aty0vrat	179	34	propose	propose	VB
cord-259237-aty0vrat	179	35	that	that	IN
cord-259237-aty0vrat	179	36	large	large	JJ
cord-259237-aty0vrat	179	37	protein	protein	NN
cord-259237-aty0vrat	179	38	aggregates	aggregate	NNS
cord-259237-aty0vrat	179	39	are	be	VBP
cord-259237-aty0vrat	179	40	disposed	dispose	VBN
cord-259237-aty0vrat	179	41	of	of	IN
cord-259237-aty0vrat	179	42	via	via	IN
cord-259237-aty0vrat	179	43	an	an	DT
cord-259237-aty0vrat	179	44	autophagy	autophagy	NN
cord-259237-aty0vrat	179	45	/	/	SYM
cord-259237-aty0vrat	179	46	lysosomal	lysosomal	NN
cord-259237-aty0vrat	179	47	pathway	pathway	NN
cord-259237-aty0vrat	179	48	,	,	,
cord-259237-aty0vrat	179	49	dubbed	dub	VBN
cord-259237-aty0vrat	179	50	ERAD	ERAD	NNP
cord-259237-aty0vrat	179	51	II	II	NNP
cord-259237-aty0vrat	179	52	[	[	-LRB-
cord-259237-aty0vrat	179	53	82	82	CD
cord-259237-aty0vrat	179	54	]	]	-RRB-
cord-259237-aty0vrat	179	55	.	.	.
cord-259237-aty0vrat	180	1	However	however	RB
cord-259237-aty0vrat	180	2	,	,	,
cord-259237-aty0vrat	180	3	under	under	IN
cord-259237-aty0vrat	180	4	ER	ER	NNP
cord-259237-aty0vrat	180	5	stress	stress	NN
cord-259237-aty0vrat	180	6	,	,	,
cord-259237-aty0vrat	180	7	most	most	JJS
cord-259237-aty0vrat	180	8	of	of	IN
cord-259237-aty0vrat	180	9	these	these	DT
cord-259237-aty0vrat	180	10	factors	factor	NNS
cord-259237-aty0vrat	180	11	are	be	VBP
cord-259237-aty0vrat	180	12	highly	highly	RB
cord-259237-aty0vrat	180	13	induced	induce	VBN
cord-259237-aty0vrat	180	14	,	,	,
cord-259237-aty0vrat	180	15	including	include	VBG
cord-259237-aty0vrat	180	16	the	the	DT
cord-259237-aty0vrat	180	17	EDEM	EDEM	NNP
cord-259237-aty0vrat	180	18	proteins	protein	NNS
cord-259237-aty0vrat	180	19	,	,	,
cord-259237-aty0vrat	180	20	but	but	CC
cord-259237-aty0vrat	180	21	not	not	RB
cord-259237-aty0vrat	180	22	ERManI	ERManI	NNP
cord-259237-aty0vrat	180	23	[	[	-LRB-
cord-259237-aty0vrat	180	24	45	45	CD
cord-259237-aty0vrat	180	25	,	,	,
cord-259237-aty0vrat	180	26	83	83	CD
cord-259237-aty0vrat	180	27	,	,	,
cord-259237-aty0vrat	180	28	84	84	CD
cord-259237-aty0vrat	180	29	]	]	-RRB-
cord-259237-aty0vrat	180	30	.	.	.
cord-259237-aty0vrat	181	1	Under	under	IN
cord-259237-aty0vrat	181	2	stress	stress	NN
cord-259237-aty0vrat	181	3	,	,	,
cord-259237-aty0vrat	181	4	QCV	QCV	NNP
cord-259237-aty0vrat	181	5	are	be	VBP
cord-259237-aty0vrat	181	6	recruited	recruit	VBN
cord-259237-aty0vrat	181	7	to	to	IN
cord-259237-aty0vrat	181	8	the	the	DT
cord-259237-aty0vrat	181	9	ERQC	ERQC	NNP
cord-259237-aty0vrat	181	10	,	,	,
cord-259237-aty0vrat	181	11	resulting	result	VBG
cord-259237-aty0vrat	181	12	in	in	IN
cord-259237-aty0vrat	181	13	the	the	DT
cord-259237-aty0vrat	181	14	accumulation	accumulation	NN
cord-259237-aty0vrat	181	15	of	of	IN
cord-259237-aty0vrat	181	16	ERManI	ERManI	NNP
cord-259237-aty0vrat	181	17	and	and	CC
cord-259237-aty0vrat	181	18	its	-PRON-	PRP$
cord-259237-aty0vrat	181	19	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	181	20	substrates	substrate	NNS
cord-259237-aty0vrat	181	21	[	[	-LRB-
cord-259237-aty0vrat	181	22	85	85	CD
cord-259237-aty0vrat	181	23	]	]	-RRB-
cord-259237-aty0vrat	181	24	.	.	.
cord-259237-aty0vrat	182	1	Moreover	moreover	RB
cord-259237-aty0vrat	182	2	,	,	,
cord-259237-aty0vrat	182	3	many	many	JJ
cord-259237-aty0vrat	182	4	other	other	JJ
cord-259237-aty0vrat	182	5	ERAD	ERAD	NNP
cord-259237-aty0vrat	182	6	components	component	NNS
cord-259237-aty0vrat	182	7	,	,	,
cord-259237-aty0vrat	182	8	including	include	VBG
cord-259237-aty0vrat	182	9	EDEM1	edem1	NN
cord-259237-aty0vrat	182	10	,	,	,
cord-259237-aty0vrat	182	11	HRD1	HRD1	NNP
cord-259237-aty0vrat	182	12	,	,	,
cord-259237-aty0vrat	182	13	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	182	14	,	,	,
cord-259237-aty0vrat	182	15	Sec61β	Sec61β	NNP
cord-259237-aty0vrat	182	16	,	,	,
cord-259237-aty0vrat	182	17	and	and	CC
cord-259237-aty0vrat	182	18	Herp	Herp	NNP
cord-259237-aty0vrat	182	19	,	,	,
cord-259237-aty0vrat	182	20	are	be	VBP
cord-259237-aty0vrat	182	21	also	also	RB
cord-259237-aty0vrat	182	22	concentrated	concentrate	VBN
cord-259237-aty0vrat	182	23	in	in	IN
cord-259237-aty0vrat	182	24	ERQC	ERQC	NNP
cord-259237-aty0vrat	182	25	.	.	.
cord-259237-aty0vrat	183	1	Importantly	importantly	RB
cord-259237-aty0vrat	183	2	,	,	,
cord-259237-aty0vrat	183	3	it	-PRON-	PRP
cord-259237-aty0vrat	183	4	has	have	VBZ
cord-259237-aty0vrat	183	5	been	be	VBN
cord-259237-aty0vrat	183	6	found	find	VBN
cord-259237-aty0vrat	183	7	that	that	DT
cord-259237-aty0vrat	183	8	EDEM1	edem1	NN
cord-259237-aty0vrat	183	9	stabilizes	stabilize	VBZ
cord-259237-aty0vrat	183	10	ERManI	ERManI	NNP
cord-259237-aty0vrat	183	11	and	and	CC
cord-259237-aty0vrat	183	12	increases	increase	VBZ
cord-259237-aty0vrat	183	13	its	-PRON-	PRP$
cord-259237-aty0vrat	183	14	protein	protein	NN
cord-259237-aty0vrat	183	15	expression	expression	NN
cord-259237-aty0vrat	183	16	at	at	IN
cord-259237-aty0vrat	183	17	steady	steady	JJ
cord-259237-aty0vrat	183	18	-	-	HYPH
cord-259237-aty0vrat	183	19	state	state	NN
cord-259237-aty0vrat	183	20	levels	level	NNS
cord-259237-aty0vrat	183	21	[	[	-LRB-
cord-259237-aty0vrat	183	22	86	86	CD
cord-259237-aty0vrat	183	23	]	]	-RRB-
cord-259237-aty0vrat	183	24	.	.	.
cord-259237-aty0vrat	184	1	Such	such	JJ
cord-259237-aty0vrat	184	2	enrichment	enrichment	NN
cord-259237-aty0vrat	184	3	of	of	IN
cord-259237-aty0vrat	184	4	these	these	DT
cord-259237-aty0vrat	184	5	critical	critical	JJ
cord-259237-aty0vrat	184	6	components	component	NNS
cord-259237-aty0vrat	184	7	accelerates	accelerate	VBZ
cord-259237-aty0vrat	184	8	efficient	efficient	JJ
cord-259237-aty0vrat	184	9	assembly	assembly	NN
cord-259237-aty0vrat	184	10	of	of	IN
cord-259237-aty0vrat	184	11	the	the	DT
cord-259237-aty0vrat	184	12	ERAD	ERAD	NNP
cord-259237-aty0vrat	184	13	machinery	machinery	NN
cord-259237-aty0vrat	184	14	,	,	,
cord-259237-aty0vrat	184	15	potentiating	potentiate	VBG
cord-259237-aty0vrat	184	16	the	the	DT
cord-259237-aty0vrat	184	17	degradation	degradation	NN
cord-259237-aty0vrat	184	18	of	of	IN
cord-259237-aty0vrat	184	19	misfolded	misfolde	VBN
cord-259237-aty0vrat	184	20	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	184	21	and	and	CC
cord-259237-aty0vrat	184	22	alleviating	alleviate	VBG
cord-259237-aty0vrat	184	23	ER	ER	NNP
cord-259237-aty0vrat	184	24	stress	stress	NN
cord-259237-aty0vrat	184	25	.	.	.
cord-259237-aty0vrat	185	1	During	during	IN
cord-259237-aty0vrat	185	2	infection	infection	NN
cord-259237-aty0vrat	185	3	,	,	,
cord-259237-aty0vrat	185	4	viruses	virus	NNS
cord-259237-aty0vrat	185	5	are	be	VBP
cord-259237-aty0vrat	185	6	able	able	JJ
cord-259237-aty0vrat	185	7	to	to	TO
cord-259237-aty0vrat	185	8	hijack	hijack	VB
cord-259237-aty0vrat	185	9	the	the	DT
cord-259237-aty0vrat	185	10	host	host	NN
cord-259237-aty0vrat	185	11	translational	translational	JJ
cord-259237-aty0vrat	185	12	machinery	machinery	NN
cord-259237-aty0vrat	185	13	and	and	CC
cord-259237-aty0vrat	185	14	saturate	saturate	VB
cord-259237-aty0vrat	185	15	the	the	DT
cord-259237-aty0vrat	185	16	ER	er	NN
cord-259237-aty0vrat	185	17	with	with	IN
cord-259237-aty0vrat	185	18	viral	viral	JJ
cord-259237-aty0vrat	185	19	proteins	protein	NNS
cord-259237-aty0vrat	185	20	.	.	.
cord-259237-aty0vrat	186	1	Not	not	RB
cord-259237-aty0vrat	186	2	only	only	RB
cord-259237-aty0vrat	186	3	do	do	VBP
cord-259237-aty0vrat	186	4	viruses	virus	NNS
cord-259237-aty0vrat	186	5	use	use	VB
cord-259237-aty0vrat	186	6	the	the	DT
cord-259237-aty0vrat	186	7	ER	ER	NNP
cord-259237-aty0vrat	186	8	to	to	TO
cord-259237-aty0vrat	186	9	generate	generate	VB
cord-259237-aty0vrat	186	10	their	-PRON-	PRP$
cord-259237-aty0vrat	186	11	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	186	12	,	,	,
cord-259237-aty0vrat	186	13	but	but	CC
cord-259237-aty0vrat	186	14	some	some	DT
cord-259237-aty0vrat	186	15	even	even	RB
cord-259237-aty0vrat	186	16	utilize	utilize	VBP
cord-259237-aty0vrat	186	17	the	the	DT
cord-259237-aty0vrat	186	18	ER	ER	NNP
cord-259237-aty0vrat	186	19	as	as	IN
cord-259237-aty0vrat	186	20	their	-PRON-	PRP$
cord-259237-aty0vrat	186	21	site	site	NN
cord-259237-aty0vrat	186	22	to	to	TO
cord-259237-aty0vrat	186	23	assemble	assemble	VB
cord-259237-aty0vrat	186	24	progeny	progeny	NN
cord-259237-aty0vrat	186	25	particles	particle	NNS
cord-259237-aty0vrat	186	26	[	[	-LRB-
cord-259237-aty0vrat	186	27	87	87	CD
cord-259237-aty0vrat	186	28	]	]	-RRB-
cord-259237-aty0vrat	186	29	.	.	.
cord-259237-aty0vrat	187	1	Such	such	JJ
cord-259237-aty0vrat	187	2	accumulation	accumulation	NN
cord-259237-aty0vrat	187	3	of	of	IN
cord-259237-aty0vrat	187	4	viral	viral	JJ
cord-259237-aty0vrat	187	5	proteins	protein	NNS
cord-259237-aty0vrat	187	6	in	in	IN
cord-259237-aty0vrat	187	7	the	the	DT
cord-259237-aty0vrat	187	8	ER	ER	NNP
cord-259237-aty0vrat	187	9	places	place	VBZ
cord-259237-aty0vrat	187	10	a	a	DT
cord-259237-aty0vrat	187	11	heavy	heavy	JJ
cord-259237-aty0vrat	187	12	demand	demand	NN
cord-259237-aty0vrat	187	13	on	on	IN
cord-259237-aty0vrat	187	14	the	the	DT
cord-259237-aty0vrat	187	15	protein	protein	NN
cord-259237-aty0vrat	187	16	folding	folding	NN
cord-259237-aty0vrat	187	17	machinery	machinery	NN
cord-259237-aty0vrat	187	18	,	,	,
cord-259237-aty0vrat	187	19	which	which	WDT
cord-259237-aty0vrat	187	20	may	may	MD
cord-259237-aty0vrat	187	21	cause	cause	VB
cord-259237-aty0vrat	187	22	ER	ER	NNP
cord-259237-aty0vrat	187	23	stress	stress	NN
cord-259237-aty0vrat	187	24	,	,	,
cord-259237-aty0vrat	187	25	and	and	CC
cord-259237-aty0vrat	187	26	in	in	IN
cord-259237-aty0vrat	187	27	turn	turn	NN
cord-259237-aty0vrat	187	28	,	,	,
cord-259237-aty0vrat	187	29	activate	activate	VB
cord-259237-aty0vrat	187	30	the	the	DT
cord-259237-aty0vrat	187	31	UPR	UPR	NNP
cord-259237-aty0vrat	187	32	,	,	,
cord-259237-aty0vrat	187	33	resulting	result	VBG
cord-259237-aty0vrat	187	34	in	in	IN
cord-259237-aty0vrat	187	35	restoration	restoration	NN
cord-259237-aty0vrat	187	36	of	of	IN
cord-259237-aty0vrat	187	37	the	the	DT
cord-259237-aty0vrat	187	38	ER	ER	NNP
cord-259237-aty0vrat	187	39	homeostasis	homeostasis	NN
cord-259237-aty0vrat	187	40	or	or	CC
cord-259237-aty0vrat	187	41	apoptosis	apoptosis	NN
cord-259237-aty0vrat	187	42	.	.	.
cord-259237-aty0vrat	188	1	So	so	RB
cord-259237-aty0vrat	188	2	far	far	RB
cord-259237-aty0vrat	188	3	,	,	,
cord-259237-aty0vrat	188	4	at	at	IN
cord-259237-aty0vrat	188	5	least	least	JJS
cord-259237-aty0vrat	188	6	36	36	CD
cord-259237-aty0vrat	188	7	viruses	virus	NNS
cord-259237-aty0vrat	188	8	have	have	VBP
cord-259237-aty0vrat	188	9	been	be	VBN
cord-259237-aty0vrat	188	10	found	find	VBN
cord-259237-aty0vrat	188	11	to	to	TO
cord-259237-aty0vrat	188	12	be	be	VB
cord-259237-aty0vrat	188	13	able	able	JJ
cord-259237-aty0vrat	188	14	to	to	TO
cord-259237-aty0vrat	188	15	induce	induce	VB
cord-259237-aty0vrat	188	16	ER	ER	NNP
cord-259237-aty0vrat	188	17	stress	stress	NN
cord-259237-aty0vrat	188	18	,	,	,
cord-259237-aty0vrat	188	19	and	and	CC
cord-259237-aty0vrat	188	20	activate	activate	VB
cord-259237-aty0vrat	188	21	the	the	DT
cord-259237-aty0vrat	188	22	three	three	CD
cord-259237-aty0vrat	188	23	UPR	UPR	NNP
cord-259237-aty0vrat	188	24	stress	stress	NN
cord-259237-aty0vrat	188	25	signaling	signal	VBG
cord-259237-aty0vrat	188	26	pathways	pathway	NNS
cord-259237-aty0vrat	188	27	[	[	-LRB-
cord-259237-aty0vrat	188	28	88	88	CD
cord-259237-aty0vrat	188	29	]	]	-RRB-
cord-259237-aty0vrat	188	30	.	.	.
cord-259237-aty0vrat	189	1	Enveloped	envelop	VBN
cord-259237-aty0vrat	189	2	viruses	virus	NNS
cord-259237-aty0vrat	189	3	may	may	MD
cord-259237-aty0vrat	189	4	bud	bud	VB
cord-259237-aty0vrat	189	5	through	through	IN
cord-259237-aty0vrat	189	6	the	the	DT
cord-259237-aty0vrat	189	7	plasma	plasma	NN
cord-259237-aty0vrat	189	8	membrane	membrane	NN
cord-259237-aty0vrat	189	9	or	or	CC
cord-259237-aty0vrat	189	10	an	an	DT
cord-259237-aty0vrat	189	11	intracellular	intracellular	JJ
cord-259237-aty0vrat	189	12	compartment	compartment	NN
cord-259237-aty0vrat	189	13	.	.	.
cord-259237-aty0vrat	190	1	In	in	IN
cord-259237-aty0vrat	190	2	addition	addition	NN
cord-259237-aty0vrat	190	3	,	,	,
cord-259237-aty0vrat	190	4	their	-PRON-	PRP$
cord-259237-aty0vrat	190	5	envelope	envelope	NN
cord-259237-aty0vrat	190	6	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	190	7	are	be	VBP
cord-259237-aty0vrat	190	8	targeted	target	VBN
cord-259237-aty0vrat	190	9	to	to	IN
cord-259237-aty0vrat	190	10	the	the	DT
cord-259237-aty0vrat	190	11	ER	ER	NNP
cord-259237-aty0vrat	190	12	for	for	IN
cord-259237-aty0vrat	190	13	post	post	JJ
cord-259237-aty0vrat	190	14	-	-	JJ
cord-259237-aty0vrat	190	15	translational	translational	JJ
cord-259237-aty0vrat	190	16	modifications	modification	NNS
cord-259237-aty0vrat	190	17	and	and	CC
cord-259237-aty0vrat	190	18	folding	folding	NN
cord-259237-aty0vrat	190	19	.	.	.
cord-259237-aty0vrat	191	1	Not	not	RB
cord-259237-aty0vrat	191	2	surprisingly	surprisingly	RB
cord-259237-aty0vrat	191	3	,	,	,
cord-259237-aty0vrat	191	4	many	many	JJ
cord-259237-aty0vrat	191	5	viral	viral	JJ
cord-259237-aty0vrat	191	6	envelope	envelope	NN
cord-259237-aty0vrat	191	7	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	191	8	are	be	VBP
cord-259237-aty0vrat	191	9	significant	significant	JJ
cord-259237-aty0vrat	191	10	inducers	inducer	NNS
cord-259237-aty0vrat	191	11	of	of	IN
cord-259237-aty0vrat	191	12	the	the	DT
cord-259237-aty0vrat	191	13	UPR	UPR	NNP
cord-259237-aty0vrat	191	14	,	,	,
cord-259237-aty0vrat	191	15	which	which	WDT
cord-259237-aty0vrat	191	16	includes	include	VBZ
cord-259237-aty0vrat	191	17	HCV	HCV	NNP
cord-259237-aty0vrat	191	18	[	[	-LRB-
cord-259237-aty0vrat	191	19	89	89	CD
cord-259237-aty0vrat	191	20	]	]	-RRB-
cord-259237-aty0vrat	191	21	,	,	,
cord-259237-aty0vrat	191	22	hepatitis	hepatitis	NNP
cord-259237-aty0vrat	191	23	B	B	NNP
cord-259237-aty0vrat	191	24	virus	virus	NN
cord-259237-aty0vrat	191	25	(	(	-LRB-
cord-259237-aty0vrat	191	26	HBV	HBV	NNP
cord-259237-aty0vrat	191	27	)	)	-RRB-
cord-259237-aty0vrat	191	28	[	[	-LRB-
cord-259237-aty0vrat	191	29	90	90	CD
cord-259237-aty0vrat	191	30	]	]	-RRB-
cord-259237-aty0vrat	191	31	,	,	,
cord-259237-aty0vrat	191	32	coronaviruses	coronaviruse	NNS
cord-259237-aty0vrat	191	33	[	[	-LRB-
cord-259237-aty0vrat	191	34	91	91	CD
cord-259237-aty0vrat	191	35	]	]	-RRB-
cord-259237-aty0vrat	191	36	,	,	,
cord-259237-aty0vrat	191	37	chikungunya	chikungunya	NN
cord-259237-aty0vrat	191	38	virus	virus	NN
cord-259237-aty0vrat	191	39	(	(	-LRB-
cord-259237-aty0vrat	191	40	CHIKV	CHIKV	NNP
cord-259237-aty0vrat	191	41	)	)	-RRB-
cord-259237-aty0vrat	191	42	[	[	-LRB-
cord-259237-aty0vrat	191	43	92	92	CD
cord-259237-aty0vrat	191	44	]	]	-RRB-
cord-259237-aty0vrat	191	45	,	,	,
cord-259237-aty0vrat	191	46	and	and	CC
cord-259237-aty0vrat	191	47	retroviruses	retrovirus	NNS
cord-259237-aty0vrat	191	48	[	[	-LRB-
cord-259237-aty0vrat	191	49	93	93	CD
cord-259237-aty0vrat	191	50	]	]	-RRB-
cord-259237-aty0vrat	191	51	.	.	.
cord-259237-aty0vrat	192	1	As	as	IN
cord-259237-aty0vrat	192	2	introduced	introduce	VBN
cord-259237-aty0vrat	192	3	earlier	early	RBR
cord-259237-aty0vrat	192	4	,	,	,
cord-259237-aty0vrat	192	5	the	the	DT
cord-259237-aty0vrat	192	6	UPR	UPR	NNP
cord-259237-aty0vrat	192	7	utilizes	utilize	VBZ
cord-259237-aty0vrat	192	8	three	three	CD
cord-259237-aty0vrat	192	9	different	different	JJ
cord-259237-aty0vrat	192	10	mechanisms	mechanism	NNS
cord-259237-aty0vrat	192	11	to	to	TO
cord-259237-aty0vrat	192	12	alleviate	alleviate	VB
cord-259237-aty0vrat	192	13	ER	ER	NNP
cord-259237-aty0vrat	192	14	stress	stress	NN
cord-259237-aty0vrat	192	15	:	:	:
cord-259237-aty0vrat	192	16	reducing	reduce	VBG
cord-259237-aty0vrat	192	17	global	global	JJ
cord-259237-aty0vrat	192	18	protein	protein	NN
cord-259237-aty0vrat	192	19	translation	translation	NN
cord-259237-aty0vrat	192	20	,	,	,
cord-259237-aty0vrat	192	21	increasing	increase	VBG
cord-259237-aty0vrat	192	22	the	the	DT
cord-259237-aty0vrat	192	23	ER	ER	NNP
cord-259237-aty0vrat	192	24	folding	folding	NN
cord-259237-aty0vrat	192	25	capacity	capacity	NN
cord-259237-aty0vrat	192	26	,	,	,
cord-259237-aty0vrat	192	27	and	and	CC
cord-259237-aty0vrat	192	28	enhancing	enhance	VBG
cord-259237-aty0vrat	192	29	ERAD	ERAD	NNP
cord-259237-aty0vrat	192	30	by	by	IN
cord-259237-aty0vrat	192	31	activating	activate	VBG
cord-259237-aty0vrat	192	32	the	the	DT
cord-259237-aty0vrat	192	33	PERK	perk	NN
cord-259237-aty0vrat	192	34	,	,	,
cord-259237-aty0vrat	192	35	ATF6	ATF6	NNP
cord-259237-aty0vrat	192	36	,	,	,
cord-259237-aty0vrat	192	37	or	or	CC
cord-259237-aty0vrat	192	38	IRE1-XBP1	IRE1-XBP1	NNP
cord-259237-aty0vrat	192	39	pathways	pathway	NNS
cord-259237-aty0vrat	192	40	,	,	,
cord-259237-aty0vrat	192	41	respectively	respectively	RB
cord-259237-aty0vrat	192	42	.	.	.
cord-259237-aty0vrat	193	1	Viral	viral	JJ
cord-259237-aty0vrat	193	2	infections	infection	NNS
cord-259237-aty0vrat	193	3	may	may	MD
cord-259237-aty0vrat	193	4	activate	activate	VB
cord-259237-aty0vrat	193	5	these	these	DT
cord-259237-aty0vrat	193	6	pathways	pathway	NNS
cord-259237-aty0vrat	193	7	,	,	,
cord-259237-aty0vrat	193	8	resulting	result	VBG
cord-259237-aty0vrat	193	9	in	in	IN
cord-259237-aty0vrat	193	10	the	the	DT
cord-259237-aty0vrat	193	11	inhibition	inhibition	NN
cord-259237-aty0vrat	193	12	or	or	CC
cord-259237-aty0vrat	193	13	enhancement	enhancement	NN
cord-259237-aty0vrat	193	14	of	of	IN
cord-259237-aty0vrat	193	15	viral	viral	JJ
cord-259237-aty0vrat	193	16	replication	replication	NN
cord-259237-aty0vrat	193	17	(	(	-LRB-
cord-259237-aty0vrat	193	18	Table	table	NN
cord-259237-aty0vrat	193	19	1	1	CD
cord-259237-aty0vrat	193	20	)	)	-RRB-
cord-259237-aty0vrat	193	21	.	.	.
cord-259237-aty0vrat	194	1	For	for	IN
cord-259237-aty0vrat	194	2	example	example	NN
cord-259237-aty0vrat	194	3	,	,	,
cord-259237-aty0vrat	194	4	the	the	DT
cord-259237-aty0vrat	194	5	PERK	perk	NN
cord-259237-aty0vrat	194	6	-	-	HYPH
cord-259237-aty0vrat	194	7	mediated	mediate	VBN
cord-259237-aty0vrat	194	8	global	global	JJ
cord-259237-aty0vrat	194	9	translation	translation	NN
cord-259237-aty0vrat	194	10	shutdown	shutdown	NN
cord-259237-aty0vrat	194	11	is	be	VBZ
cord-259237-aty0vrat	194	12	a	a	DT
cord-259237-aty0vrat	194	13	very	very	RB
cord-259237-aty0vrat	194	14	effective	effective	JJ
cord-259237-aty0vrat	194	15	antiviral	antiviral	JJ
cord-259237-aty0vrat	194	16	mechanism	mechanism	NN
cord-259237-aty0vrat	194	17	,	,	,
cord-259237-aty0vrat	194	18	and	and	CC
cord-259237-aty0vrat	194	19	a	a	DT
cord-259237-aty0vrat	194	20	similar	similar	JJ
cord-259237-aty0vrat	194	21	shutdown	shutdown	NN
cord-259237-aty0vrat	194	22	by	by	IN
cord-259237-aty0vrat	194	23	PKR	PKR	NNP
cord-259237-aty0vrat	194	24	has	have	VBZ
cord-259237-aty0vrat	194	25	been	be	VBN
cord-259237-aty0vrat	194	26	used	use	VBN
cord-259237-aty0vrat	194	27	in	in	IN
cord-259237-aty0vrat	194	28	the	the	DT
cord-259237-aty0vrat	194	29	interferon	interferon	NN
cord-259237-aty0vrat	194	30	pathway	pathway	NN
cord-259237-aty0vrat	194	31	to	to	TO
cord-259237-aty0vrat	194	32	defend	defend	VB
cord-259237-aty0vrat	194	33	against	against	IN
cord-259237-aty0vrat	194	34	viral	viral	JJ
cord-259237-aty0vrat	194	35	infection	infection	NN
cord-259237-aty0vrat	194	36	[	[	-LRB-
cord-259237-aty0vrat	194	37	94	94	CD
cord-259237-aty0vrat	194	38	]	]	-RRB-
cord-259237-aty0vrat	194	39	.	.	.
cord-259237-aty0vrat	195	1	Conceivably	conceivably	RB
cord-259237-aty0vrat	195	2	,	,	,
cord-259237-aty0vrat	195	3	viruses	virus	NNS
cord-259237-aty0vrat	195	4	have	have	VBP
cord-259237-aty0vrat	195	5	evolved	evolve	VBN
cord-259237-aty0vrat	195	6	a	a	DT
cord-259237-aty0vrat	195	7	number	number	NN
cord-259237-aty0vrat	195	8	of	of	IN
cord-259237-aty0vrat	195	9	strategies	strategy	NNS
cord-259237-aty0vrat	195	10	to	to	TO
cord-259237-aty0vrat	195	11	circumvent	circumvent	VB
cord-259237-aty0vrat	195	12	the	the	DT
cord-259237-aty0vrat	195	13	detrimental	detrimental	JJ
cord-259237-aty0vrat	195	14	effect	effect	NN
cord-259237-aty0vrat	195	15	of	of	IN
cord-259237-aty0vrat	195	16	UPR	UPR	NNP
cord-259237-aty0vrat	195	17	to	to	TO
cord-259237-aty0vrat	195	18	establish	establish	VB
cord-259237-aty0vrat	195	19	productive	productive	JJ
cord-259237-aty0vrat	195	20	infection	infection	NN
cord-259237-aty0vrat	195	21	.	.	.
cord-259237-aty0vrat	196	1	HCV	HCV	NNP
cord-259237-aty0vrat	196	2	is	be	VBZ
cord-259237-aty0vrat	196	3	still	still	RB
cord-259237-aty0vrat	196	4	able	able	JJ
cord-259237-aty0vrat	196	5	to	to	TO
cord-259237-aty0vrat	196	6	produce	produce	VB
cord-259237-aty0vrat	196	7	viral	viral	JJ
cord-259237-aty0vrat	196	8	proteins	protein	NNS
cord-259237-aty0vrat	196	9	even	even	RB
cord-259237-aty0vrat	196	10	when	when	WRB
cord-259237-aty0vrat	196	11	the	the	DT
cord-259237-aty0vrat	196	12	cellular	cellular	JJ
cord-259237-aty0vrat	196	13	translational	translational	JJ
cord-259237-aty0vrat	196	14	machinery	machinery	NN
cord-259237-aty0vrat	196	15	is	be	VBZ
cord-259237-aty0vrat	196	16	shut	shut	VBN
cord-259237-aty0vrat	196	17	down	down	RP
cord-259237-aty0vrat	196	18	,	,	,
cord-259237-aty0vrat	196	19	because	because	IN
cord-259237-aty0vrat	196	20	these	these	DT
cord-259237-aty0vrat	196	21	viruses	virus	NNS
cord-259237-aty0vrat	196	22	have	have	VBP
cord-259237-aty0vrat	196	23	their	-PRON-	PRP$
cord-259237-aty0vrat	196	24	own	own	JJ
cord-259237-aty0vrat	196	25	internal	internal	JJ
cord-259237-aty0vrat	196	26	ribosome	ribosome	NN
cord-259237-aty0vrat	196	27	entry	entry	NN
cord-259237-aty0vrat	196	28	site	site	NN
cord-259237-aty0vrat	196	29	(	(	-LRB-
cord-259237-aty0vrat	196	30	IRES	IRES	NNP
cord-259237-aty0vrat	196	31	)	)	-RRB-
cord-259237-aty0vrat	196	32	to	to	TO
cord-259237-aty0vrat	196	33	recruit	recruit	VB
cord-259237-aty0vrat	196	34	and	and	CC
cord-259237-aty0vrat	196	35	assemble	assemble	VB
cord-259237-aty0vrat	196	36	the	the	DT
cord-259237-aty0vrat	196	37	ribosomal	ribosomal	JJ
cord-259237-aty0vrat	196	38	initiation	initiation	NN
cord-259237-aty0vrat	196	39	complex	complex	NN
cord-259237-aty0vrat	196	40	for	for	IN
cord-259237-aty0vrat	196	41	protein	protein	NN
cord-259237-aty0vrat	196	42	expression	expression	NN
cord-259237-aty0vrat	196	43	[	[	-LRB-
cord-259237-aty0vrat	196	44	95	95	CD
cord-259237-aty0vrat	196	45	]	]	-RRB-
cord-259237-aty0vrat	196	46	.	.	.
cord-259237-aty0vrat	197	1	Epstein	Epstein	NNP
cord-259237-aty0vrat	197	2	-	-	HYPH
cord-259237-aty0vrat	197	3	Barr	Barr	NNP
cord-259237-aty0vrat	197	4	virus	virus	NN
cord-259237-aty0vrat	197	5	(	(	-LRB-
cord-259237-aty0vrat	197	6	EBV	EBV	NNP
cord-259237-aty0vrat	197	7	)	)	-RRB-
cord-259237-aty0vrat	197	8	,	,	,
cord-259237-aty0vrat	197	9	herpes	herpes	NN
cord-259237-aty0vrat	197	10	simplex	simplex	NNP
cord-259237-aty0vrat	197	11	virus	virus	NN
cord-259237-aty0vrat	197	12	(	(	-LRB-
cord-259237-aty0vrat	197	13	HSV	HSV	NNP
cord-259237-aty0vrat	197	14	)	)	-RRB-
cord-259237-aty0vrat	197	15	,	,	,
cord-259237-aty0vrat	197	16	and	and	CC
cord-259237-aty0vrat	197	17	African	african	JJ
cord-259237-aty0vrat	197	18	swine	swine	NN
cord-259237-aty0vrat	197	19	fever	fever	NN
cord-259237-aty0vrat	197	20	virus	virus	NN
cord-259237-aty0vrat	197	21	(	(	-LRB-
cord-259237-aty0vrat	197	22	ASFV	ASFV	NNP
cord-259237-aty0vrat	197	23	)	)	-RRB-
cord-259237-aty0vrat	197	24	can	can	MD
cord-259237-aty0vrat	197	25	counteract	counteract	VB
cord-259237-aty0vrat	197	26	the	the	DT
cord-259237-aty0vrat	197	27	PERK	perk	NN
cord-259237-aty0vrat	197	28	-	-	HYPH
cord-259237-aty0vrat	197	29	mediated	mediate	VBN
cord-259237-aty0vrat	197	30	eIF2α	eif2α	JJ
cord-259237-aty0vrat	197	31	phosphorylation	phosphorylation	NN
cord-259237-aty0vrat	197	32	by	by	IN
cord-259237-aty0vrat	197	33	activating	activate	VBG
cord-259237-aty0vrat	197	34	an	an	DT
cord-259237-aty0vrat	197	35	eIF2α	eif2α	JJ
cord-259237-aty0vrat	197	36	phosphatase	phosphatase	NN
cord-259237-aty0vrat	197	37	PP1	pp1	NN
cord-259237-aty0vrat	197	38	[	[	-LRB-
cord-259237-aty0vrat	197	39	96	96	CD
cord-259237-aty0vrat	197	40	]	]	-RRB-
cord-259237-aty0vrat	197	41	[	[	-LRB-
cord-259237-aty0vrat	197	42	97	97	CD
cord-259237-aty0vrat	197	43	]	]	-RRB-
cord-259237-aty0vrat	197	44	[	[	-LRB-
cord-259237-aty0vrat	197	45	98	98	CD
cord-259237-aty0vrat	197	46	]	]	-RRB-
cord-259237-aty0vrat	197	47	.	.	.
cord-259237-aty0vrat	198	1	In	in	IN
cord-259237-aty0vrat	198	2	another	another	DT
cord-259237-aty0vrat	198	3	example	example	NN
cord-259237-aty0vrat	198	4	,	,	,
cord-259237-aty0vrat	198	5	the	the	DT
cord-259237-aty0vrat	198	6	HCV	HCV	NNP
cord-259237-aty0vrat	198	7	E2	E2	NNP
cord-259237-aty0vrat	198	8	protein	protein	NN
cord-259237-aty0vrat	198	9	directly	directly	RB
cord-259237-aty0vrat	198	10	interacts	interact	VBZ
cord-259237-aty0vrat	198	11	with	with	IN
cord-259237-aty0vrat	198	12	PERK	perk	NN
cord-259237-aty0vrat	198	13	to	to	TO
cord-259237-aty0vrat	198	14	prevent	prevent	VB
cord-259237-aty0vrat	198	15	ER	ER	NNP
cord-259237-aty0vrat	198	16	stress	stress	NN
cord-259237-aty0vrat	198	17	sensing	sensing	NN
cord-259237-aty0vrat	198	18	by	by	IN
cord-259237-aty0vrat	198	19	acting	act	VBG
cord-259237-aty0vrat	198	20	as	as	IN
cord-259237-aty0vrat	198	21	a	a	DT
cord-259237-aty0vrat	198	22	pseudo	pseudo	JJ
cord-259237-aty0vrat	198	23	-	-	NN
cord-259237-aty0vrat	198	24	substrate	substrate	NN
cord-259237-aty0vrat	198	25	to	to	TO
cord-259237-aty0vrat	198	26	block	block	NN
cord-259237-aty0vrat	198	27	PERK	perk	NN
cord-259237-aty0vrat	198	28	activity	activity	NN
cord-259237-aty0vrat	198	29	[	[	-LRB-
cord-259237-aty0vrat	198	30	99	99	CD
cord-259237-aty0vrat	198	31	]	]	-RRB-
cord-259237-aty0vrat	198	32	.	.	.
cord-259237-aty0vrat	199	1	In	in	IN
cord-259237-aty0vrat	199	2	addition	addition	NN
cord-259237-aty0vrat	199	3	to	to	IN
cord-259237-aty0vrat	199	4	combating	combat	VBG
cord-259237-aty0vrat	199	5	the	the	DT
cord-259237-aty0vrat	199	6	UPR	UPR	NNP
cord-259237-aty0vrat	199	7	,	,	,
cord-259237-aty0vrat	199	8	viruses	virus	NNS
cord-259237-aty0vrat	199	9	also	also	RB
cord-259237-aty0vrat	199	10	take	take	VBP
cord-259237-aty0vrat	199	11	advantage	advantage	NN
cord-259237-aty0vrat	199	12	of	of	IN
cord-259237-aty0vrat	199	13	the	the	DT
cord-259237-aty0vrat	199	14	UPR	UPR	NNP
cord-259237-aty0vrat	199	15	pathways	pathway	NNS
cord-259237-aty0vrat	199	16	to	to	TO
cord-259237-aty0vrat	199	17	benefit	benefit	VB
cord-259237-aty0vrat	199	18	their	-PRON-	PRP$
cord-259237-aty0vrat	199	19	replication	replication	NN
cord-259237-aty0vrat	199	20	.	.	.
cord-259237-aty0vrat	200	1	For	for	IN
cord-259237-aty0vrat	200	2	example	example	NN
cord-259237-aty0vrat	200	3	,	,	,
cord-259237-aty0vrat	200	4	influenza	influenza	NN
cord-259237-aty0vrat	200	5	A	a	DT
cord-259237-aty0vrat	200	6	virus	virus	NN
cord-259237-aty0vrat	200	7	(	(	-LRB-
cord-259237-aty0vrat	200	8	IAV	iav	NN
cord-259237-aty0vrat	200	9	)	)	-RRB-
cord-259237-aty0vrat	200	10	replication	replication	NN
cord-259237-aty0vrat	200	11	is	be	VBZ
cord-259237-aty0vrat	200	12	promoted	promote	VBN
cord-259237-aty0vrat	200	13	by	by	IN
cord-259237-aty0vrat	200	14	activation	activation	NN
cord-259237-aty0vrat	200	15	of	of	IN
cord-259237-aty0vrat	200	16	the	the	DT
cord-259237-aty0vrat	200	17	IRE1-XBP1	IRE1-XBP1	NNP
cord-259237-aty0vrat	200	18	pathway	pathway	NN
cord-259237-aty0vrat	200	19	[	[	-LRB-
cord-259237-aty0vrat	200	20	100	100	CD
cord-259237-aty0vrat	200	21	]	]	-RRB-
cord-259237-aty0vrat	200	22	;	;	:
cord-259237-aty0vrat	200	23	ATF6	atf6	JJ
cord-259237-aty0vrat	200	24	activation	activation	NN
cord-259237-aty0vrat	200	25	promotes	promote	VBZ
cord-259237-aty0vrat	200	26	ASFV	ASFV	NNP
cord-259237-aty0vrat	200	27	,	,	,
cord-259237-aty0vrat	200	28	lymphocytic	lymphocytic	JJ
cord-259237-aty0vrat	200	29	choriomeningitis	choriomeningitis	NNP
cord-259237-aty0vrat	200	30	virus	virus	NN
cord-259237-aty0vrat	200	31	(	(	-LRB-
cord-259237-aty0vrat	200	32	LCMV	LCMV	NNP
cord-259237-aty0vrat	200	33	)	)	-RRB-
cord-259237-aty0vrat	200	34	,	,	,
cord-259237-aty0vrat	200	35	DENV	DENV	NNP
cord-259237-aty0vrat	200	36	,	,	,
cord-259237-aty0vrat	200	37	human	human	JJ
cord-259237-aty0vrat	200	38	cytomegalovirus	cytomegalovirus	NN
cord-259237-aty0vrat	200	39	(	(	-LRB-
cord-259237-aty0vrat	200	40	HCMV	HCMV	NNP
cord-259237-aty0vrat	200	41	)	)	-RRB-
cord-259237-aty0vrat	200	42	,	,	,
cord-259237-aty0vrat	200	43	and	and	CC
cord-259237-aty0vrat	200	44	Japan	Japan	NNP
cord-259237-aty0vrat	200	45	encephalitis	encephalitis	NNP
cord-259237-aty0vrat	200	46	virus	virus	NN
cord-259237-aty0vrat	200	47	(	(	-LRB-
cord-259237-aty0vrat	200	48	JEV	JEV	NNP
cord-259237-aty0vrat	200	49	)	)	-RRB-
cord-259237-aty0vrat	200	50	replication	replication	NN
cord-259237-aty0vrat	200	51	[	[	-LRB-
cord-259237-aty0vrat	200	52	101	101	CD
cord-259237-aty0vrat	200	53	,	,	,
cord-259237-aty0vrat	200	54	102	102	CD
cord-259237-aty0vrat	200	55	]	]	-RRB-
cord-259237-aty0vrat	200	56	,	,	,
cord-259237-aty0vrat	200	57	and	and	CC
cord-259237-aty0vrat	200	58	ATF4	ATF4	NNP
cord-259237-aty0vrat	200	59	activation	activation	NN
cord-259237-aty0vrat	200	60	enhances	enhance	VBZ
cord-259237-aty0vrat	200	61	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	200	62	replication	replication	NN
cord-259237-aty0vrat	200	63	[	[	-LRB-
cord-259237-aty0vrat	200	64	103	103	CD
cord-259237-aty0vrat	200	65	]	]	-RRB-
cord-259237-aty0vrat	200	66	.	.	.
cord-259237-aty0vrat	201	1	Thus	thus	RB
cord-259237-aty0vrat	201	2	,	,	,
cord-259237-aty0vrat	201	3	despite	despite	IN
cord-259237-aty0vrat	201	4	the	the	DT
cord-259237-aty0vrat	201	5	detrimental	detrimental	JJ
cord-259237-aty0vrat	201	6	effects	effect	NNS
cord-259237-aty0vrat	201	7	,	,	,
cord-259237-aty0vrat	201	8	viruses	virus	NNS
cord-259237-aty0vrat	201	9	have	have	VBP
cord-259237-aty0vrat	201	10	evolved	evolve	VBN
cord-259237-aty0vrat	201	11	to	to	TO
cord-259237-aty0vrat	201	12	manipulate	manipulate	VB
cord-259237-aty0vrat	201	13	host	host	NN
cord-259237-aty0vrat	201	14	UPR	UPR	NNP
cord-259237-aty0vrat	201	15	signaling	signal	VBG
cord-259237-aty0vrat	201	16	pathways	pathway	NNS
cord-259237-aty0vrat	201	17	to	to	TO
cord-259237-aty0vrat	201	18	promote	promote	VB
cord-259237-aty0vrat	201	19	viral	viral	JJ
cord-259237-aty0vrat	201	20	infections	infection	NNS
cord-259237-aty0vrat	201	21	.	.	.
cord-259237-aty0vrat	202	1	Below	below	RB
cord-259237-aty0vrat	202	2	,	,	,
cord-259237-aty0vrat	202	3	we	-PRON-	PRP
cord-259237-aty0vrat	202	4	will	will	MD
cord-259237-aty0vrat	202	5	focus	focus	VB
cord-259237-aty0vrat	202	6	on	on	IN
cord-259237-aty0vrat	202	7	the	the	DT
cord-259237-aty0vrat	202	8	roles	role	NNS
cord-259237-aty0vrat	202	9	of	of	IN
cord-259237-aty0vrat	202	10	ERAD	ERAD	NNP
cord-259237-aty0vrat	202	11	played	play	VBD
cord-259237-aty0vrat	202	12	in	in	IN
cord-259237-aty0vrat	202	13	virus	virus	NN
cord-259237-aty0vrat	202	14	replication	replication	NN
cord-259237-aty0vrat	202	15	,	,	,
cord-259237-aty0vrat	202	16	which	which	WDT
cord-259237-aty0vrat	202	17	is	be	VBZ
cord-259237-aty0vrat	202	18	the	the	DT
cord-259237-aty0vrat	202	19	main	main	JJ
cord-259237-aty0vrat	202	20	target	target	NN
cord-259237-aty0vrat	202	21	of	of	IN
cord-259237-aty0vrat	202	22	this	this	DT
cord-259237-aty0vrat	202	23	review	review	NN
cord-259237-aty0vrat	202	24	.	.	.
cord-259237-aty0vrat	202	25	 	 	_SP
cord-259237-aty0vrat	203	1	As	as	IN
cord-259237-aty0vrat	203	2	introduced	introduce	VBN
cord-259237-aty0vrat	203	3	earlier	early	RBR
cord-259237-aty0vrat	203	4	,	,	,
cord-259237-aty0vrat	203	5	ERAD	ERAD	NNP
cord-259237-aty0vrat	203	6	transports	transport	VBZ
cord-259237-aty0vrat	203	7	unfolded	unfold	VBN
cord-259237-aty0vrat	203	8	/	/	SYM
cord-259237-aty0vrat	203	9	misfolded	misfolde	VBN
cord-259237-aty0vrat	203	10	proteins	protein	NNS
cord-259237-aty0vrat	203	11	from	from	IN
cord-259237-aty0vrat	203	12	the	the	DT
cord-259237-aty0vrat	203	13	ER	ER	NNP
cord-259237-aty0vrat	203	14	into	into	IN
cord-259237-aty0vrat	203	15	the	the	DT
cord-259237-aty0vrat	203	16	cytosol	cytosol	NN
cord-259237-aty0vrat	203	17	for	for	IN
cord-259237-aty0vrat	203	18	proteasomal	proteasomal	JJ
cord-259237-aty0vrat	203	19	degradation	degradation	NN
cord-259237-aty0vrat	203	20	.	.	.
cord-259237-aty0vrat	204	1	Conceivably	conceivably	RB
cord-259237-aty0vrat	204	2	,	,	,
cord-259237-aty0vrat	204	3	viruses	virus	NNS
cord-259237-aty0vrat	204	4	can	can	MD
cord-259237-aty0vrat	204	5	manipulate	manipulate	VB
cord-259237-aty0vrat	204	6	and	and	CC
cord-259237-aty0vrat	204	7	exploit	exploit	VB
cord-259237-aty0vrat	204	8	this	this	DT
cord-259237-aty0vrat	204	9	cellular	cellular	JJ
cord-259237-aty0vrat	204	10	machinery	machinery	NN
cord-259237-aty0vrat	204	11	to	to	TO
cord-259237-aty0vrat	204	12	degrade	degrade	VB
cord-259237-aty0vrat	204	13	several	several	JJ
cord-259237-aty0vrat	204	14	important	important	JJ
cord-259237-aty0vrat	204	15	host	host	NN
cord-259237-aty0vrat	204	16	factors	factor	NNS
cord-259237-aty0vrat	204	17	to	to	TO
cord-259237-aty0vrat	204	18	promote	promote	VB
cord-259237-aty0vrat	204	19	their	-PRON-	PRP$
cord-259237-aty0vrat	204	20	propagation	propagation	NN
cord-259237-aty0vrat	204	21	.	.	.
cord-259237-aty0vrat	205	1	Herpesviruses	Herpesviruses	NNP
cord-259237-aty0vrat	205	2	have	have	VBP
cord-259237-aty0vrat	205	3	evolved	evolve	VBN
cord-259237-aty0vrat	205	4	multiple	multiple	JJ
cord-259237-aty0vrat	205	5	mechanisms	mechanism	NNS
cord-259237-aty0vrat	205	6	to	to	TO
cord-259237-aty0vrat	205	7	suppress	suppress	VB
cord-259237-aty0vrat	205	8	the	the	DT
cord-259237-aty0vrat	205	9	host	host	NN
cord-259237-aty0vrat	205	10	immune	immune	JJ
cord-259237-aty0vrat	205	11	response	response	NN
cord-259237-aty0vrat	205	12	via	via	IN
cord-259237-aty0vrat	205	13	ERAD	ERAD	NNP
cord-259237-aty0vrat	205	14	.	.	.
cord-259237-aty0vrat	206	1	Major	major	JJ
cord-259237-aty0vrat	206	2	histocompatibility	histocompatibility	NN
cord-259237-aty0vrat	206	3	complex	complex	NN
cord-259237-aty0vrat	206	4	(	(	-LRB-
cord-259237-aty0vrat	206	5	MHC	MHC	NNP
cord-259237-aty0vrat	206	6	)	)	-RRB-
cord-259237-aty0vrat	206	7	molecules	molecule	NNS
cord-259237-aty0vrat	206	8	play	play	VBP
cord-259237-aty0vrat	206	9	an	an	DT
cord-259237-aty0vrat	206	10	indispensable	indispensable	JJ
cord-259237-aty0vrat	206	11	role	role	NN
cord-259237-aty0vrat	206	12	in	in	IN
cord-259237-aty0vrat	206	13	triggering	trigger	VBG
cord-259237-aty0vrat	206	14	an	an	DT
cord-259237-aty0vrat	206	15	immediate	immediate	JJ
cord-259237-aty0vrat	206	16	immune	immune	JJ
cord-259237-aty0vrat	206	17	response	response	NN
cord-259237-aty0vrat	206	18	to	to	TO
cord-259237-aty0vrat	206	19	inhibit	inhibit	VB
cord-259237-aty0vrat	206	20	virus	virus	NN
cord-259237-aty0vrat	206	21	infections	infection	NNS
cord-259237-aty0vrat	206	22	.	.	.
cord-259237-aty0vrat	207	1	Herpesviruses	Herpesviruses	NNP
cord-259237-aty0vrat	207	2	inhibit	inhibit	VBP
cord-259237-aty0vrat	207	3	MHC	MHC	NNP
cord-259237-aty0vrat	207	4	class	class	NN
cord-259237-aty0vrat	208	1	I	-PRON-	PRP
cord-259237-aty0vrat	208	2	(	(	-LRB-
cord-259237-aty0vrat	208	3	MHC	MHC	NNP
cord-259237-aty0vrat	208	4	-	-	HYPH
cord-259237-aty0vrat	208	5	I	I	NNP
cord-259237-aty0vrat	208	6	)	)	-RRB-
cord-259237-aty0vrat	208	7	expression	expression	NN
cord-259237-aty0vrat	208	8	by	by	IN
cord-259237-aty0vrat	208	9	targeting	target	VBG
cord-259237-aty0vrat	208	10	these	these	DT
cord-259237-aty0vrat	208	11	molecules	molecule	NNS
cord-259237-aty0vrat	208	12	to	to	IN
cord-259237-aty0vrat	208	13	ERAD	ERAD	NNP
cord-259237-aty0vrat	208	14	for	for	IN
cord-259237-aty0vrat	208	15	degradation	degradation	NN
cord-259237-aty0vrat	208	16	.	.	.
cord-259237-aty0vrat	209	1	For	for	IN
cord-259237-aty0vrat	209	2	example	example	NN
cord-259237-aty0vrat	209	3	,	,	,
cord-259237-aty0vrat	209	4	HCMV	HCMV	NNP
cord-259237-aty0vrat	209	5	produces	produce	VBZ
cord-259237-aty0vrat	209	6	two	two	CD
cord-259237-aty0vrat	209	7	transmembrane	transmembrane	NN
cord-259237-aty0vrat	209	8	proteins	protein	NNS
cord-259237-aty0vrat	209	9	,	,	,
cord-259237-aty0vrat	209	10	US2	US2	NNP
cord-259237-aty0vrat	209	11	and	and	CC
cord-259237-aty0vrat	209	12	US11	US11	NNP
cord-259237-aty0vrat	209	13	,	,	,
cord-259237-aty0vrat	209	14	and	and	CC
cord-259237-aty0vrat	209	15	each	each	DT
cord-259237-aty0vrat	209	16	is	be	VBZ
cord-259237-aty0vrat	209	17	sufficient	sufficient	JJ
cord-259237-aty0vrat	209	18	to	to	TO
cord-259237-aty0vrat	209	19	bind	bind	VB
cord-259237-aty0vrat	209	20	to	to	IN
cord-259237-aty0vrat	209	21	MHC	MHC	NNP
cord-259237-aty0vrat	209	22	-	-	:
cord-259237-aty0vrat	209	23	I	-PRON-	PRP
cord-259237-aty0vrat	209	24	heavy	heavy	JJ
cord-259237-aty0vrat	209	25	chains	chain	NNS
cord-259237-aty0vrat	209	26	,	,	,
cord-259237-aty0vrat	209	27	causing	cause	VBG
cord-259237-aty0vrat	209	28	their	-PRON-	PRP$
cord-259237-aty0vrat	209	29	dislocation	dislocation	NN
cord-259237-aty0vrat	209	30	from	from	IN
cord-259237-aty0vrat	209	31	the	the	DT
cord-259237-aty0vrat	209	32	ER	ER	NNP
cord-259237-aty0vrat	209	33	to	to	IN
cord-259237-aty0vrat	209	34	the	the	DT
cord-259237-aty0vrat	209	35	cytosol	cytosol	NN
cord-259237-aty0vrat	209	36	for	for	IN
cord-259237-aty0vrat	209	37	degradation	degradation	NN
cord-259237-aty0vrat	209	38	[	[	-LRB-
cord-259237-aty0vrat	209	39	108	108	CD
cord-259237-aty0vrat	209	40	]	]	-RRB-
cord-259237-aty0vrat	209	41	.	.	.
cord-259237-aty0vrat	210	1	Notably	notably	RB
cord-259237-aty0vrat	210	2	,	,	,
cord-259237-aty0vrat	210	3	US2	US2	NNP
cord-259237-aty0vrat	210	4	and	and	CC
cord-259237-aty0vrat	210	5	US11	US11	NNP
cord-259237-aty0vrat	210	6	use	use	VB
cord-259237-aty0vrat	210	7	different	different	JJ
cord-259237-aty0vrat	210	8	mechanisms	mechanism	NNS
cord-259237-aty0vrat	210	9	to	to	TO
cord-259237-aty0vrat	210	10	degrade	degrade	VB
cord-259237-aty0vrat	210	11	MHC	MHC	NNP
cord-259237-aty0vrat	210	12	-	-	HYPH
cord-259237-aty0vrat	210	13	I.	I.	NNP
cord-259237-aty0vrat	210	14	US2-dependent	us2-dependent	NN
cord-259237-aty0vrat	210	15	MHC	MHC	NNP
cord-259237-aty0vrat	210	16	-	-	:
cord-259237-aty0vrat	210	17	I	-PRON-	PRP
cord-259237-aty0vrat	210	18	degradation	degradation	NN
cord-259237-aty0vrat	210	19	is	be	VBZ
cord-259237-aty0vrat	210	20	mediated	mediate	VBN
cord-259237-aty0vrat	210	21	through	through	IN
cord-259237-aty0vrat	210	22	an	an	DT
cord-259237-aty0vrat	210	23	interaction	interaction	NN
cord-259237-aty0vrat	210	24	with	with	IN
cord-259237-aty0vrat	210	25	the	the	DT
cord-259237-aty0vrat	210	26	E3	e3	NN
cord-259237-aty0vrat	210	27	ligase	ligase	NN
cord-259237-aty0vrat	210	28	,	,	,
cord-259237-aty0vrat	210	29	TRC8	TRC8	NNP
cord-259237-aty0vrat	210	30	.	.	.
cord-259237-aty0vrat	211	1	This	this	DT
cord-259237-aty0vrat	211	2	US2	US2	NNP
cord-259237-aty0vrat	211	3	/	/	SYM
cord-259237-aty0vrat	211	4	TRC8	TRC8	NNP
cord-259237-aty0vrat	211	5	complex	complex	NN
cord-259237-aty0vrat	211	6	has	have	VBZ
cord-259237-aty0vrat	211	7	been	be	VBN
cord-259237-aty0vrat	211	8	implicated	implicate	VBN
cord-259237-aty0vrat	211	9	in	in	IN
cord-259237-aty0vrat	211	10	the	the	DT
cord-259237-aty0vrat	211	11	degradation	degradation	NN
cord-259237-aty0vrat	211	12	of	of	IN
cord-259237-aty0vrat	211	13	other	other	JJ
cord-259237-aty0vrat	211	14	membrane	membrane	NN
cord-259237-aty0vrat	211	15	proteins	protein	NNS
cord-259237-aty0vrat	211	16	including	include	VBG
cord-259237-aty0vrat	211	17	multiple	multiple	JJ
cord-259237-aty0vrat	211	18	alpha	alpha	NN
cord-259237-aty0vrat	211	19	-	-	HYPH
cord-259237-aty0vrat	211	20	integrins	integrin	NNS
cord-259237-aty0vrat	211	21	,	,	,
cord-259237-aty0vrat	211	22	the	the	DT
cord-259237-aty0vrat	211	23	interleukin	interleukin	NN
cord-259237-aty0vrat	211	24	12	12	CD
cord-259237-aty0vrat	211	25	receptor	receptor	NN
cord-259237-aty0vrat	211	26	(	(	-LRB-
cord-259237-aty0vrat	211	27	IL-12R	IL-12R	NNP
cord-259237-aty0vrat	211	28	)	)	-RRB-
cord-259237-aty0vrat	211	29	,	,	,
cord-259237-aty0vrat	211	30	thrombomodulin	thrombomodulin	NNP
cord-259237-aty0vrat	211	31	(	(	-LRB-
cord-259237-aty0vrat	211	32	THBD	THBD	NNP
cord-259237-aty0vrat	211	33	)	)	-RRB-
cord-259237-aty0vrat	211	34	,	,	,
cord-259237-aty0vrat	211	35	protein	protein	NN
cord-259237-aty0vrat	211	36	tyrosine	tyrosine	NN
cord-259237-aty0vrat	211	37	phosphatase	phosphatase	NN
cord-259237-aty0vrat	211	38	receptor	receptor	NN
cord-259237-aty0vrat	211	39	type	type	NN
cord-259237-aty0vrat	211	40	J	J	NNP
cord-259237-aty0vrat	211	41	(	(	-LRB-
cord-259237-aty0vrat	211	42	PTPRJ	PTPRJ	NNP
cord-259237-aty0vrat	211	43	)	)	-RRB-
cord-259237-aty0vrat	211	44	,	,	,
cord-259237-aty0vrat	211	45	and	and	CC
cord-259237-aty0vrat	211	46	CD112	CD112	NNP
cord-259237-aty0vrat	211	47	[	[	-LRB-
cord-259237-aty0vrat	211	48	109	109	CD
cord-259237-aty0vrat	211	49	]	]	-RRB-
cord-259237-aty0vrat	211	50	.	.	.
cord-259237-aty0vrat	212	1	Although	although	IN
cord-259237-aty0vrat	212	2	the	the	DT
cord-259237-aty0vrat	212	3	signal	signal	NN
cord-259237-aty0vrat	212	4	peptide	peptide	NN
cord-259237-aty0vrat	212	5	peptidase	peptidase	NN
cord-259237-aty0vrat	212	6	(	(	-LRB-
cord-259237-aty0vrat	212	7	SPP	SPP	NNP
cord-259237-aty0vrat	212	8	)	)	-RRB-
cord-259237-aty0vrat	212	9	has	have	VBZ
cord-259237-aty0vrat	212	10	been	be	VBN
cord-259237-aty0vrat	212	11	shown	show	VBN
cord-259237-aty0vrat	212	12	to	to	TO
cord-259237-aty0vrat	212	13	bind	bind	VB
cord-259237-aty0vrat	212	14	to	to	IN
cord-259237-aty0vrat	212	15	TRC8	TRC8	NNP
cord-259237-aty0vrat	212	16	,	,	,
cord-259237-aty0vrat	212	17	the	the	DT
cord-259237-aty0vrat	212	18	US2	US2	NNP
cord-259237-aty0vrat	212	19	/	/	SYM
cord-259237-aty0vrat	212	20	TRC8	TRC8	NNP
cord-259237-aty0vrat	212	21	complex	complex	NN
cord-259237-aty0vrat	212	22	maintains	maintain	VBZ
cord-259237-aty0vrat	212	23	its	-PRON-	PRP$
cord-259237-aty0vrat	212	24	MHC-1	mhc-1	JJ
cord-259237-aty0vrat	212	25	degradation	degradation	NN
cord-259237-aty0vrat	212	26	activity	activity	NN
cord-259237-aty0vrat	212	27	in	in	IN
cord-259237-aty0vrat	212	28	SPP−/−	SPP−/−	NNP
cord-259237-aty0vrat	212	29	knockout	knockout	NN
cord-259237-aty0vrat	212	30	cells	cell	NNS
cord-259237-aty0vrat	212	31	,	,	,
cord-259237-aty0vrat	212	32	suggesting	suggest	VBG
cord-259237-aty0vrat	212	33	that	that	IN
cord-259237-aty0vrat	212	34	SPP	spp	NN
cord-259237-aty0vrat	212	35	binding	binding	NN
cord-259237-aty0vrat	212	36	is	be	VBZ
cord-259237-aty0vrat	212	37	not	not	RB
cord-259237-aty0vrat	212	38	related	relate	VBN
cord-259237-aty0vrat	212	39	to	to	IN
cord-259237-aty0vrat	212	40	MHC-1	mhc-1	JJ
cord-259237-aty0vrat	212	41	degradation	degradation	NN
cord-259237-aty0vrat	212	42	[	[	-LRB-
cord-259237-aty0vrat	212	43	110	110	CD
cord-259237-aty0vrat	212	44	,	,	,
cord-259237-aty0vrat	212	45	111	111	CD
cord-259237-aty0vrat	212	46	]	]	-RRB-
cord-259237-aty0vrat	212	47	.	.	.
cord-259237-aty0vrat	213	1	Recent	recent	JJ
cord-259237-aty0vrat	213	2	reports	report	NNS
cord-259237-aty0vrat	213	3	now	now	RB
cord-259237-aty0vrat	213	4	regard	regard	VBP
cord-259237-aty0vrat	213	5	the	the	DT
cord-259237-aty0vrat	213	6	US2	US2	NNP
cord-259237-aty0vrat	213	7	/	/	SYM
cord-259237-aty0vrat	213	8	TRC8	TRC8	NNP
cord-259237-aty0vrat	213	9	complex	complex	NN
cord-259237-aty0vrat	213	10	as	as	IN
cord-259237-aty0vrat	213	11	a	a	DT
cord-259237-aty0vrat	213	12	multifunctional	multifunctional	JJ
cord-259237-aty0vrat	213	13	hub	hub	NN
cord-259237-aty0vrat	213	14	that	that	WDT
cord-259237-aty0vrat	213	15	is	be	VBZ
cord-259237-aty0vrat	213	16	able	able	JJ
cord-259237-aty0vrat	213	17	to	to	TO
cord-259237-aty0vrat	213	18	degrade	degrade	VB
cord-259237-aty0vrat	213	19	a	a	DT
cord-259237-aty0vrat	213	20	multitude	multitude	NN
cord-259237-aty0vrat	213	21	of	of	IN
cord-259237-aty0vrat	213	22	targets	target	NNS
cord-259237-aty0vrat	213	23	in	in	IN
cord-259237-aty0vrat	213	24	order	order	NN
cord-259237-aty0vrat	213	25	to	to	TO
cord-259237-aty0vrat	213	26	further	further	JJ
cord-259237-aty0vrat	213	27	HCMV	HCMV	NNP
cord-259237-aty0vrat	213	28	immune	immune	JJ
cord-259237-aty0vrat	213	29	evasion	evasion	NN
cord-259237-aty0vrat	213	30	[	[	-LRB-
cord-259237-aty0vrat	213	31	109	109	CD
cord-259237-aty0vrat	213	32	,	,	,
cord-259237-aty0vrat	213	33	112	112	CD
cord-259237-aty0vrat	213	34	]	]	-RRB-
cord-259237-aty0vrat	213	35	.	.	.
cord-259237-aty0vrat	214	1	A	a	DT
cord-259237-aty0vrat	214	2	complex	complex	NN
cord-259237-aty0vrat	214	3	formed	form	VBN
cord-259237-aty0vrat	214	4	between	between	IN
cord-259237-aty0vrat	214	5	US11	US11	NNP
cord-259237-aty0vrat	214	6	,	,	,
cord-259237-aty0vrat	214	7	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	214	8	,	,	,
cord-259237-aty0vrat	214	9	and	and	CC
cord-259237-aty0vrat	214	10	the	the	DT
cord-259237-aty0vrat	214	11	E3	e3	NN
cord-259237-aty0vrat	214	12	ligase	ligase	NN
cord-259237-aty0vrat	214	13	,	,	,
cord-259237-aty0vrat	214	14	TMEM129	TMEM129	NNP
cord-259237-aty0vrat	214	15	,	,	,
cord-259237-aty0vrat	214	16	mediates	mediate	VBZ
cord-259237-aty0vrat	214	17	MHC	MHC	NNP
cord-259237-aty0vrat	214	18	-	-	HYPH
cord-259237-aty0vrat	214	19	I	-PRON-	PRP
cord-259237-aty0vrat	214	20	degradation	degradation	NN
cord-259237-aty0vrat	214	21	via	via	IN
cord-259237-aty0vrat	214	22	US11	US11	NNP
cord-259237-aty0vrat	214	23	[	[	-LRB-
cord-259237-aty0vrat	214	24	113	113	CD
cord-259237-aty0vrat	214	25	]	]	-RRB-
cord-259237-aty0vrat	214	26	.	.	.
cord-259237-aty0vrat	215	1	Initial	initial	JJ
cord-259237-aty0vrat	215	2	reports	report	NNS
cord-259237-aty0vrat	215	3	concerning	concern	VBG
cord-259237-aty0vrat	215	4	US11	US11	NNP
cord-259237-aty0vrat	215	5	found	find	VBD
cord-259237-aty0vrat	215	6	an	an	DT
cord-259237-aty0vrat	215	7	association	association	NN
cord-259237-aty0vrat	215	8	with	with	IN
cord-259237-aty0vrat	215	9	SEL1L	SEL1L	NNP
cord-259237-aty0vrat	215	10	and	and	CC
cord-259237-aty0vrat	215	11	assumed	assume	VBD
cord-259237-aty0vrat	215	12	that	that	IN
cord-259237-aty0vrat	215	13	US11	US11	NNP
cord-259237-aty0vrat	215	14	mediated	mediate	VBD
cord-259237-aty0vrat	215	15	MHC-1	MHC-1	NNP
cord-259237-aty0vrat	215	16	degradation	degradation	NN
cord-259237-aty0vrat	215	17	could	could	MD
cord-259237-aty0vrat	215	18	be	be	VB
cord-259237-aty0vrat	215	19	SEL1L	sel1l	JJ
cord-259237-aty0vrat	215	20	/	/	SYM
cord-259237-aty0vrat	215	21	HRD1	HRD1	NNP
cord-259237-aty0vrat	215	22	dependent	dependent	JJ
cord-259237-aty0vrat	215	23	.	.	.
cord-259237-aty0vrat	216	1	Recent	recent	JJ
cord-259237-aty0vrat	216	2	literature	literature	NN
cord-259237-aty0vrat	216	3	has	have	VBZ
cord-259237-aty0vrat	216	4	confirmed	confirm	VBN
cord-259237-aty0vrat	216	5	that	that	IN
cord-259237-aty0vrat	216	6	while	while	IN
cord-259237-aty0vrat	216	7	the	the	DT
cord-259237-aty0vrat	216	8	US11	US11	NNP
cord-259237-aty0vrat	216	9	/	/	SYM
cord-259237-aty0vrat	216	10	TMEM129	TMEM129	NNP
cord-259237-aty0vrat	216	11	complex	complex	NN
cord-259237-aty0vrat	216	12	degrades	degrade	VBZ
cord-259237-aty0vrat	216	13	MHC-1	MHC-1	NNP
cord-259237-aty0vrat	216	14	,	,	,
cord-259237-aty0vrat	216	15	US11	US11	NNP
cord-259237-aty0vrat	216	16	itself	-PRON-	PRP
cord-259237-aty0vrat	216	17	is	be	VBZ
cord-259237-aty0vrat	216	18	degraded	degrade	VBN
cord-259237-aty0vrat	216	19	through	through	IN
cord-259237-aty0vrat	216	20	a	a	DT
cord-259237-aty0vrat	216	21	SEL1L	sel1l	JJ
cord-259237-aty0vrat	216	22	/	/	SYM
cord-259237-aty0vrat	216	23	HRD1	HRD1	NNP
cord-259237-aty0vrat	216	24	axis	axis	NN
cord-259237-aty0vrat	216	25	in	in	IN
cord-259237-aty0vrat	216	26	the	the	DT
cord-259237-aty0vrat	216	27	absence	absence	NN
cord-259237-aty0vrat	216	28	of	of	IN
cord-259237-aty0vrat	216	29	the	the	DT
cord-259237-aty0vrat	216	30	client	client	NN
cord-259237-aty0vrat	216	31	MHC-1	MHC-1	NNP
cord-259237-aty0vrat	217	1	[	[	-LRB-
cord-259237-aty0vrat	217	2	113	113	CD
cord-259237-aty0vrat	217	3	,	,	,
cord-259237-aty0vrat	217	4	114	114	CD
cord-259237-aty0vrat	217	5	]	]	-RRB-
cord-259237-aty0vrat	217	6	.	.	.
cord-259237-aty0vrat	218	1	Recruitment	recruitment	NN
cord-259237-aty0vrat	218	2	of	of	IN
cord-259237-aty0vrat	218	3	p97	p97	CD
cord-259237-aty0vrat	218	4	by	by	IN
cord-259237-aty0vrat	218	5	Ubxd8	Ubxd8	NNP
cord-259237-aty0vrat	218	6	is	be	VBZ
cord-259237-aty0vrat	218	7	also	also	RB
cord-259237-aty0vrat	218	8	crucial	crucial	JJ
cord-259237-aty0vrat	218	9	for	for	IN
cord-259237-aty0vrat	218	10	US11-mediated	us11-mediated	CD
cord-259237-aty0vrat	218	11	MHC	MHC	NNP
cord-259237-aty0vrat	218	12	-	-	:
cord-259237-aty0vrat	218	13	I	-PRON-	PRP
cord-259237-aty0vrat	218	14	degradation	degradation	NN
cord-259237-aty0vrat	218	15	[	[	-LRB-
cord-259237-aty0vrat	218	16	115	115	CD
cord-259237-aty0vrat	218	17	]	]	-RRB-
cord-259237-aty0vrat	218	18	.	.	.
cord-259237-aty0vrat	219	1	With	with	IN
cord-259237-aty0vrat	219	2	regard	regard	NN
cord-259237-aty0vrat	219	3	to	to	IN
cord-259237-aty0vrat	219	4	US11	US11	NNP
cord-259237-aty0vrat	219	5	,	,	,
cord-259237-aty0vrat	219	6	HCMV	HCMV	NNP
cord-259237-aty0vrat	219	7	utilizes	utilize	VBZ
cord-259237-aty0vrat	219	8	ERAD	ERAD	NNP
cord-259237-aty0vrat	219	9	to	to	TO
cord-259237-aty0vrat	219	10	dispose	dispose	VB
cord-259237-aty0vrat	219	11	of	of	IN
cord-259237-aty0vrat	219	12	MHC	MHC	NNP
cord-259237-aty0vrat	219	13	-	-	:
cord-259237-aty0vrat	219	14	I	I	NNP
cord-259237-aty0vrat	219	15	and	and	CC
cord-259237-aty0vrat	219	16	its	-PRON-	PRP$
cord-259237-aty0vrat	219	17	own	own	JJ
cord-259237-aty0vrat	219	18	effector	effector	NN
cord-259237-aty0vrat	219	19	protein	protein	NN
cord-259237-aty0vrat	219	20	using	use	VBG
cord-259237-aty0vrat	219	21	discrete	discrete	JJ
cord-259237-aty0vrat	219	22	axes	axis	NNS
cord-259237-aty0vrat	219	23	for	for	IN
cord-259237-aty0vrat	219	24	ubiquitination	ubiquitination	NN
cord-259237-aty0vrat	219	25	.	.	.
cord-259237-aty0vrat	220	1	Mouse	Mouse	NNP
cord-259237-aty0vrat	220	2	gammaherpesvirus	gammaherpesvirus	NNP
cord-259237-aty0vrat	220	3	68	68	CD
cord-259237-aty0vrat	221	1	(	(	-LRB-
cord-259237-aty0vrat	221	2	MHV68	MHV68	NNP
cord-259237-aty0vrat	221	3	)	)	-RRB-
cord-259237-aty0vrat	221	4	uses	use	VBZ
cord-259237-aty0vrat	221	5	another	another	DT
cord-259237-aty0vrat	221	6	mechanism	mechanism	NN
cord-259237-aty0vrat	221	7	to	to	TO
cord-259237-aty0vrat	221	8	inhibit	inhibit	VB
cord-259237-aty0vrat	222	1	MHC	MHC	NNP
cord-259237-aty0vrat	222	2	-	-	HYPH
cord-259237-aty0vrat	222	3	I.	I.	NNP
cord-259237-aty0vrat	222	4	MHV68	MHV68	NNP
cord-259237-aty0vrat	222	5	produces	produce	VBZ
cord-259237-aty0vrat	222	6	a	a	DT
cord-259237-aty0vrat	222	7	protein	protein	NN
cord-259237-aty0vrat	222	8	termed	term	VBN
cord-259237-aty0vrat	222	9	MK3	MK3	NNP
cord-259237-aty0vrat	222	10	,	,	,
cord-259237-aty0vrat	222	11	which	which	WDT
cord-259237-aty0vrat	222	12	is	be	VBZ
cord-259237-aty0vrat	222	13	a	a	DT
cord-259237-aty0vrat	222	14	Ring	ring	NN
cord-259237-aty0vrat	222	15	-	-	HYPH
cord-259237-aty0vrat	222	16	finger	finger	NN
cord-259237-aty0vrat	222	17	E3	e3	NN
cord-259237-aty0vrat	222	18	ligase	ligase	NN
cord-259237-aty0vrat	222	19	anchored	anchor	VBN
cord-259237-aty0vrat	222	20	on	on	IN
cord-259237-aty0vrat	222	21	the	the	DT
cord-259237-aty0vrat	222	22	ER	ER	NNP
cord-259237-aty0vrat	222	23	membrane	membrane	NN
cord-259237-aty0vrat	222	24	.	.	.
cord-259237-aty0vrat	223	1	MK3	MK3	NNP
cord-259237-aty0vrat	223	2	interacts	interact	VBZ
cord-259237-aty0vrat	223	3	with	with	IN
cord-259237-aty0vrat	223	4	MHC	MHC	NNP
cord-259237-aty0vrat	223	5	-	-	:
cord-259237-aty0vrat	223	6	I	-PRON-	PRP
cord-259237-aty0vrat	223	7	heavy	heavy	JJ
cord-259237-aty0vrat	223	8	chain	chain	NN
cord-259237-aty0vrat	223	9	molecules	molecule	NNS
cord-259237-aty0vrat	223	10	,	,	,
cord-259237-aty0vrat	223	11	and	and	CC
cord-259237-aty0vrat	223	12	it	-PRON-	PRP
cord-259237-aty0vrat	223	13	also	also	RB
cord-259237-aty0vrat	223	14	associates	associate	VBZ
cord-259237-aty0vrat	223	15	with	with	IN
cord-259237-aty0vrat	223	16	the	the	DT
cord-259237-aty0vrat	223	17	transporter	transporter	NN
cord-259237-aty0vrat	223	18	associated	associate	VBN
cord-259237-aty0vrat	223	19	with	with	IN
cord-259237-aty0vrat	223	20	antigen	antigen	NN
cord-259237-aty0vrat	223	21	processing	processing	NN
cord-259237-aty0vrat	223	22	(	(	-LRB-
cord-259237-aty0vrat	223	23	TAP	TAP	NNP
cord-259237-aty0vrat	223	24	)	)	-RRB-
cord-259237-aty0vrat	223	25	,	,	,
cord-259237-aty0vrat	223	26	p97	p97	CD
cord-259237-aty0vrat	223	27	,	,	,
cord-259237-aty0vrat	223	28	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	223	29	,	,	,
cord-259237-aty0vrat	223	30	and	and	CC
cord-259237-aty0vrat	223	31	the	the	DT
cord-259237-aty0vrat	223	32	E2	E2	NNP
cord-259237-aty0vrat	223	33	Ube2J2	Ube2J2	NNP
cord-259237-aty0vrat	223	34	.	.	.
cord-259237-aty0vrat	224	1	Association	Association	NNP
cord-259237-aty0vrat	224	2	with	with	IN
cord-259237-aty0vrat	224	3	Ube2J2	Ube2J2	NNP
cord-259237-aty0vrat	224	4	results	result	NNS
cord-259237-aty0vrat	224	5	in	in	IN
cord-259237-aty0vrat	224	6	an	an	DT
cord-259237-aty0vrat	224	7	interesting	interesting	JJ
cord-259237-aty0vrat	224	8	pattern	pattern	NN
cord-259237-aty0vrat	224	9	of	of	IN
cord-259237-aty0vrat	224	10	ubiquitination	ubiquitination	NN
cord-259237-aty0vrat	224	11	of	of	IN
cord-259237-aty0vrat	224	12	non	non	JJ
cord-259237-aty0vrat	224	13	-	-	JJ
cord-259237-aty0vrat	224	14	lysine	lysine	JJ
cord-259237-aty0vrat	224	15	residues	residue	NNS
cord-259237-aty0vrat	224	16	(	(	-LRB-
cord-259237-aty0vrat	224	17	the	the	DT
cord-259237-aty0vrat	224	18	MK3	MK3	NNP
cord-259237-aty0vrat	224	19	/	/	SYM
cord-259237-aty0vrat	224	20	Ube2J2	Ube2J2	NNP
cord-259237-aty0vrat	224	21	complex	complex	JJ
cord-259237-aty0vrat	225	1	can	can	MD
cord-259237-aty0vrat	225	2	ubiquitinate	ubiquitinate	VB
cord-259237-aty0vrat	225	3	serines	serines	NNPS
cord-259237-aty0vrat	225	4	as	as	RB
cord-259237-aty0vrat	225	5	well	well	RB
cord-259237-aty0vrat	225	6	as	as	IN
cord-259237-aty0vrat	225	7	lysines	lysines	NNP
cord-259237-aty0vrat	225	8	)	)	-RRB-
cord-259237-aty0vrat	225	9	that	that	WDT
cord-259237-aty0vrat	225	10	leads	lead	VBZ
cord-259237-aty0vrat	225	11	to	to	IN
cord-259237-aty0vrat	225	12	rapid	rapid	JJ
cord-259237-aty0vrat	225	13	degradation	degradation	NN
cord-259237-aty0vrat	225	14	of	of	IN
cord-259237-aty0vrat	225	15	the	the	DT
cord-259237-aty0vrat	225	16	MHC	MHC	NNP
cord-259237-aty0vrat	226	1	-I	-i	WDT
cord-259237-aty0vrat	226	2	by	by	IN
cord-259237-aty0vrat	226	3	proteasomes	proteasomes	NNP
cord-259237-aty0vrat	226	4	[	[	-LRB-
cord-259237-aty0vrat	226	5	73	73	CD
cord-259237-aty0vrat	226	6	,	,	,
cord-259237-aty0vrat	226	7	116	116	CD
cord-259237-aty0vrat	226	8	]	]	-RRB-
cord-259237-aty0vrat	226	9	.	.	.
cord-259237-aty0vrat	227	1	Thus	thus	RB
cord-259237-aty0vrat	227	2	,	,	,
cord-259237-aty0vrat	227	3	herpesviruses	herpesviruse	NNS
cord-259237-aty0vrat	227	4	have	have	VBP
cord-259237-aty0vrat	227	5	evolved	evolve	VBN
cord-259237-aty0vrat	227	6	numerous	numerous	JJ
cord-259237-aty0vrat	227	7	strategies	strategy	NNS
cord-259237-aty0vrat	227	8	to	to	TO
cord-259237-aty0vrat	227	9	block	block	VB
cord-259237-aty0vrat	227	10	the	the	DT
cord-259237-aty0vrat	227	11	MHC	MHC	NNP
cord-259237-aty0vrat	227	12	antigen	antigen	NN
cord-259237-aty0vrat	227	13	presentation	presentation	NN
cord-259237-aty0vrat	227	14	and	and	CC
cord-259237-aty0vrat	227	15	evade	evade	VB
cord-259237-aty0vrat	227	16	the	the	DT
cord-259237-aty0vrat	227	17	host	host	NN
cord-259237-aty0vrat	227	18	immune	immune	JJ
cord-259237-aty0vrat	227	19	response	response	NN
cord-259237-aty0vrat	227	20	to	to	TO
cord-259237-aty0vrat	227	21	establish	establish	VB
cord-259237-aty0vrat	227	22	a	a	DT
cord-259237-aty0vrat	227	23	persistent	persistent	JJ
cord-259237-aty0vrat	227	24	infection	infection	NN
cord-259237-aty0vrat	227	25	.	.	.
cord-259237-aty0vrat	228	1	Primate	primate	JJ
cord-259237-aty0vrat	228	2	lentiviruses	lentiviruse	NNS
cord-259237-aty0vrat	228	3	also	also	RB
cord-259237-aty0vrat	228	4	harness	harness	VBP
cord-259237-aty0vrat	228	5	the	the	DT
cord-259237-aty0vrat	228	6	ERAD	ERAD	NNP
cord-259237-aty0vrat	228	7	pathway	pathway	NN
cord-259237-aty0vrat	228	8	to	to	TO
cord-259237-aty0vrat	228	9	promote	promote	VB
cord-259237-aty0vrat	228	10	their	-PRON-	PRP$
cord-259237-aty0vrat	228	11	replication	replication	NN
cord-259237-aty0vrat	228	12	via	via	IN
cord-259237-aty0vrat	228	13	downregulation	downregulation	NN
cord-259237-aty0vrat	228	14	of	of	IN
cord-259237-aty0vrat	228	15	their	-PRON-	PRP$
cord-259237-aty0vrat	228	16	receptor	receptor	NN
cord-259237-aty0vrat	228	17	CD4	CD4	NNP
cord-259237-aty0vrat	228	18	.	.	.
cord-259237-aty0vrat	229	1	CD4	CD4	NNP
cord-259237-aty0vrat	229	2	downregulation	downregulation	NN
cord-259237-aty0vrat	229	3	prevents	prevent	VBZ
cord-259237-aty0vrat	229	4	superinfection	superinfection	NN
cord-259237-aty0vrat	229	5	and	and	CC
cord-259237-aty0vrat	229	6	promotes	promote	VBZ
cord-259237-aty0vrat	229	7	viral	viral	JJ
cord-259237-aty0vrat	229	8	release	release	NN
cord-259237-aty0vrat	229	9	by	by	IN
cord-259237-aty0vrat	229	10	interrupting	interrupt	VBG
cord-259237-aty0vrat	229	11	viral	viral	JJ
cord-259237-aty0vrat	229	12	receptor	receptor	NN
cord-259237-aty0vrat	229	13	-	-	HYPH
cord-259237-aty0vrat	229	14	envelope	envelope	NN
cord-259237-aty0vrat	229	15	interactions	interaction	NNS
cord-259237-aty0vrat	229	16	on	on	IN
cord-259237-aty0vrat	229	17	the	the	DT
cord-259237-aty0vrat	229	18	plasma	plasma	NN
cord-259237-aty0vrat	229	19	membrane	membrane	NN
cord-259237-aty0vrat	229	20	,	,	,
cord-259237-aty0vrat	229	21	leading	lead	VBG
cord-259237-aty0vrat	229	22	to	to	IN
cord-259237-aty0vrat	229	23	a	a	DT
cord-259237-aty0vrat	229	24	controlled	control	VBN
cord-259237-aty0vrat	229	25	and	and	CC
cord-259237-aty0vrat	229	26	productive	productive	JJ
cord-259237-aty0vrat	229	27	viral	viral	JJ
cord-259237-aty0vrat	229	28	infection	infection	NN
cord-259237-aty0vrat	229	29	and	and	CC
cord-259237-aty0vrat	229	30	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	229	31	[	[	-LRB-
cord-259237-aty0vrat	229	32	117	117	CD
cord-259237-aty0vrat	229	33	]	]	-RRB-
cord-259237-aty0vrat	229	34	.	.	.
cord-259237-aty0vrat	230	1	These	these	DT
cord-259237-aty0vrat	230	2	viruses	virus	NNS
cord-259237-aty0vrat	230	3	produce	produce	VBP
cord-259237-aty0vrat	230	4	two	two	CD
cord-259237-aty0vrat	230	5	accessory	accessory	NN
cord-259237-aty0vrat	230	6	proteins	protein	NNS
cord-259237-aty0vrat	230	7	,	,	,
cord-259237-aty0vrat	230	8	Nef	Nef	NNP
cord-259237-aty0vrat	230	9	and	and	CC
cord-259237-aty0vrat	230	10	Vpu	Vpu	NNP
cord-259237-aty0vrat	230	11	,	,	,
cord-259237-aty0vrat	230	12	to	to	TO
cord-259237-aty0vrat	230	13	trigger	trigger	VB
cord-259237-aty0vrat	230	14	CD4	CD4	NNP
cord-259237-aty0vrat	230	15	degradation	degradation	NN
cord-259237-aty0vrat	230	16	via	via	IN
cord-259237-aty0vrat	230	17	two	two	CD
cord-259237-aty0vrat	230	18	distinctive	distinctive	JJ
cord-259237-aty0vrat	230	19	mechanisms	mechanism	NNS
cord-259237-aty0vrat	230	20	[	[	-LRB-
cord-259237-aty0vrat	230	21	118	118	CD
cord-259237-aty0vrat	230	22	]	]	-RRB-
cord-259237-aty0vrat	230	23	.	.	.
cord-259237-aty0vrat	231	1	Nef	Nef	NNP
cord-259237-aty0vrat	231	2	uses	use	VBZ
cord-259237-aty0vrat	231	3	the	the	DT
cord-259237-aty0vrat	231	4	endocytic	endocytic	JJ
cord-259237-aty0vrat	231	5	pathway	pathway	NN
cord-259237-aty0vrat	231	6	to	to	TO
cord-259237-aty0vrat	231	7	redirect	redirect	VB
cord-259237-aty0vrat	231	8	CD4	CD4	NNP
cord-259237-aty0vrat	231	9	from	from	IN
cord-259237-aty0vrat	231	10	the	the	DT
cord-259237-aty0vrat	231	11	cell	cell	NN
cord-259237-aty0vrat	231	12	surface	surface	NN
cord-259237-aty0vrat	231	13	,	,	,
cord-259237-aty0vrat	231	14	or	or	CC
cord-259237-aty0vrat	231	15	to	to	TO
cord-259237-aty0vrat	231	16	interfere	interfere	VB
cord-259237-aty0vrat	231	17	with	with	IN
cord-259237-aty0vrat	231	18	the	the	DT
cord-259237-aty0vrat	231	19	transport	transport	NN
cord-259237-aty0vrat	231	20	of	of	IN
cord-259237-aty0vrat	231	21	newly	newly	RB
cord-259237-aty0vrat	231	22	synthesized	synthesize	VBN
cord-259237-aty0vrat	231	23	CD4	CD4	NNP
cord-259237-aty0vrat	231	24	from	from	IN
cord-259237-aty0vrat	231	25	the	the	DT
cord-259237-aty0vrat	231	26	trans	trans	NNP
cord-259237-aty0vrat	231	27	-	-	NNP
cord-259237-aty0vrat	231	28	Golgi	Golgi	NNP
cord-259237-aty0vrat	231	29	network	network	NN
cord-259237-aty0vrat	231	30	(	(	-LRB-
cord-259237-aty0vrat	231	31	TGN	TGN	NNP
cord-259237-aty0vrat	231	32	)	)	-RRB-
cord-259237-aty0vrat	231	33	to	to	IN
cord-259237-aty0vrat	231	34	the	the	DT
cord-259237-aty0vrat	231	35	cell	cell	NN
cord-259237-aty0vrat	231	36	surface	surface	NN
cord-259237-aty0vrat	231	37	,	,	,
cord-259237-aty0vrat	231	38	resulting	result	VBG
cord-259237-aty0vrat	231	39	in	in	IN
cord-259237-aty0vrat	231	40	CD4	CD4	NNP
cord-259237-aty0vrat	231	41	dislocation	dislocation	NN
cord-259237-aty0vrat	231	42	to	to	IN
cord-259237-aty0vrat	231	43	endosomes	endosome	NNS
cord-259237-aty0vrat	231	44	and	and	CC
cord-259237-aty0vrat	231	45	degradation	degradation	NN
cord-259237-aty0vrat	231	46	by	by	IN
cord-259237-aty0vrat	231	47	lysosomes	lysosome	NNS
cord-259237-aty0vrat	231	48	[	[	-LRB-
cord-259237-aty0vrat	231	49	119	119	CD
cord-259237-aty0vrat	231	50	]	]	-RRB-
cord-259237-aty0vrat	231	51	.	.	.
cord-259237-aty0vrat	232	1	However	however	RB
cord-259237-aty0vrat	232	2	,	,	,
cord-259237-aty0vrat	232	3	Vpu	Vpu	NNP
cord-259237-aty0vrat	232	4	interacts	interact	VBZ
cord-259237-aty0vrat	232	5	with	with	IN
cord-259237-aty0vrat	232	6	CD4	CD4	NNP
cord-259237-aty0vrat	232	7	in	in	IN
cord-259237-aty0vrat	232	8	the	the	DT
cord-259237-aty0vrat	232	9	ER	er	NN
cord-259237-aty0vrat	232	10	and	and	CC
cord-259237-aty0vrat	232	11	induces	induce	VBZ
cord-259237-aty0vrat	232	12	CD4	CD4	NNP
cord-259237-aty0vrat	232	13	proteasomal	proteasomal	JJ
cord-259237-aty0vrat	232	14	degradation	degradation	NN
cord-259237-aty0vrat	232	15	via	via	IN
cord-259237-aty0vrat	232	16	ERAD	ERAD	NNP
cord-259237-aty0vrat	232	17	[	[	-LRB-
cord-259237-aty0vrat	232	18	120	120	CD
cord-259237-aty0vrat	232	19	]	]	-RRB-
cord-259237-aty0vrat	232	20	.	.	.
cord-259237-aty0vrat	233	1	Vpu	Vpu	NNP
cord-259237-aty0vrat	233	2	is	be	VBZ
cord-259237-aty0vrat	233	3	a	a	DT
cord-259237-aty0vrat	233	4	small	small	JJ
cord-259237-aty0vrat	233	5	transmembrane	transmembrane	NN
cord-259237-aty0vrat	233	6	protein	protein	NN
cord-259237-aty0vrat	233	7	encoded	encode	VBN
cord-259237-aty0vrat	233	8	by	by	IN
cord-259237-aty0vrat	233	9	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	233	10	and	and	CC
cord-259237-aty0vrat	233	11	some	some	DT
cord-259237-aty0vrat	233	12	simian	simian	JJ
cord-259237-aty0vrat	233	13	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	233	14	virus	virus	NN
cord-259237-aty0vrat	233	15	(	(	-LRB-
cord-259237-aty0vrat	233	16	SIV	SIV	NNP
cord-259237-aty0vrat	233	17	)	)	-RRB-
cord-259237-aty0vrat	233	18	isolates	isolate	NNS
cord-259237-aty0vrat	233	19	.	.	.
cord-259237-aty0vrat	234	1	Vpu	Vpu	NNP
cord-259237-aty0vrat	234	2	forms	form	NNS
cord-259237-aty0vrat	234	3	ion	ion	NN
cord-259237-aty0vrat	234	4	conductive	conductive	JJ
cord-259237-aty0vrat	234	5	membrane	membrane	NN
cord-259237-aty0vrat	234	6	pores	pore	NNS
cord-259237-aty0vrat	234	7	;	;	:
cord-259237-aty0vrat	234	8	it	-PRON-	PRP
cord-259237-aty0vrat	234	9	also	also	RB
cord-259237-aty0vrat	234	10	interacts	interact	VBZ
cord-259237-aty0vrat	234	11	with	with	IN
cord-259237-aty0vrat	234	12	β	β	NNP
cord-259237-aty0vrat	234	13	-	-	HYPH
cord-259237-aty0vrat	234	14	transducin	transducin	NNP
cord-259237-aty0vrat	234	15	repeat	repeat	NN
cord-259237-aty0vrat	234	16	-	-	HYPH
cord-259237-aty0vrat	234	17	containing	contain	VBG
cord-259237-aty0vrat	234	18	proteins	protein	NNS
cord-259237-aty0vrat	234	19	(	(	-LRB-
cord-259237-aty0vrat	234	20	βTrCP	βTrCP	NNP
cord-259237-aty0vrat	234	21	)	)	-RRB-
cord-259237-aty0vrat	234	22	,	,	,
cord-259237-aty0vrat	234	23	which	which	WDT
cord-259237-aty0vrat	234	24	are	be	VBP
cord-259237-aty0vrat	234	25	F	F	NNP
cord-259237-aty0vrat	234	26	-	-	HYPH
cord-259237-aty0vrat	234	27	box	box	NNP
cord-259237-aty0vrat	234	28	/	/	SYM
cord-259237-aty0vrat	234	29	WD	WD	NNP
cord-259237-aty0vrat	234	30	repeat	repeat	NN
cord-259237-aty0vrat	234	31	-	-	HYPH
cord-259237-aty0vrat	234	32	containing	contain	VBG
cord-259237-aty0vrat	234	33	proteins	protein	NNS
cord-259237-aty0vrat	234	34	that	that	WDT
cord-259237-aty0vrat	234	35	are	be	VBP
cord-259237-aty0vrat	234	36	part	part	NN
cord-259237-aty0vrat	234	37	of	of	IN
cord-259237-aty0vrat	234	38	the	the	DT
cord-259237-aty0vrat	234	39	Skp1-Cul1-F	Skp1-Cul1-F	NNP
cord-259237-aty0vrat	234	40	-	-	HYPH
cord-259237-aty0vrat	234	41	box	box	NN
cord-259237-aty0vrat	234	42	(	(	-LRB-
cord-259237-aty0vrat	234	43	SCF	SCF	NNP
cord-259237-aty0vrat	234	44	)	)	-RRB-
cord-259237-aty0vrat	234	45	E3	e3	NN
cord-259237-aty0vrat	234	46	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	234	47	ligase	ligase	NN
cord-259237-aty0vrat	234	48	complex	complex	NN
cord-259237-aty0vrat	234	49	[	[	-LRB-
cord-259237-aty0vrat	234	50	121	121	CD
cord-259237-aty0vrat	234	51	]	]	-RRB-
cord-259237-aty0vrat	234	52	.	.	.
cord-259237-aty0vrat	235	1	The	the	DT
cord-259237-aty0vrat	235	2	Vpu	Vpu	NNP
cord-259237-aty0vrat	235	3	-	-	HYPH
cord-259237-aty0vrat	235	4	induced	induce	VBN
cord-259237-aty0vrat	235	5	CD4	CD4	NNP
cord-259237-aty0vrat	235	6	degradation	degradation	NN
cord-259237-aty0vrat	235	7	is	be	VBZ
cord-259237-aty0vrat	235	8	strictly	strictly	RB
cord-259237-aty0vrat	235	9	dependent	dependent	JJ
cord-259237-aty0vrat	235	10	on	on	IN
cord-259237-aty0vrat	235	11	the	the	DT
cord-259237-aty0vrat	235	12	SCF	SCF	NNP
cord-259237-aty0vrat	235	13	-	-	HYPH
cord-259237-aty0vrat	235	14	β	β	NN
cord-259237-aty0vrat	235	15	-	-	HYPH
cord-259237-aty0vrat	235	16	TrCP	trcp	NN
cord-259237-aty0vrat	235	17	complex	complex	NN
cord-259237-aty0vrat	235	18	[	[	-LRB-
cord-259237-aty0vrat	235	19	122	122	CD
cord-259237-aty0vrat	235	20	]	]	-RRB-
cord-259237-aty0vrat	235	21	.	.	.
cord-259237-aty0vrat	236	1	Notably	notably	RB
cord-259237-aty0vrat	236	2	,	,	,
cord-259237-aty0vrat	236	3	this	this	DT
cord-259237-aty0vrat	236	4	E3	e3	NN
cord-259237-aty0vrat	236	5	ligase	ligase	NN
cord-259237-aty0vrat	236	6	complex	complex	NN
cord-259237-aty0vrat	236	7	is	be	VBZ
cord-259237-aty0vrat	236	8	not	not	RB
cord-259237-aty0vrat	236	9	associated	associate	VBN
cord-259237-aty0vrat	236	10	with	with	IN
cord-259237-aty0vrat	236	11	the	the	DT
cord-259237-aty0vrat	236	12	ER	ER	NNP
cord-259237-aty0vrat	236	13	membrane	membrane	NN
cord-259237-aty0vrat	236	14	,	,	,
cord-259237-aty0vrat	236	15	and	and	CC
cord-259237-aty0vrat	236	16	therefore	therefore	RB
cord-259237-aty0vrat	236	17	does	do	VBZ
cord-259237-aty0vrat	236	18	not	not	RB
cord-259237-aty0vrat	236	19	normally	normally	RB
cord-259237-aty0vrat	236	20	function	function	VB
cord-259237-aty0vrat	236	21	in	in	IN
cord-259237-aty0vrat	236	22	ERAD	ERAD	NNP
cord-259237-aty0vrat	236	23	.	.	.
cord-259237-aty0vrat	237	1	However	however	RB
cord-259237-aty0vrat	237	2	,	,	,
cord-259237-aty0vrat	237	3	the	the	DT
cord-259237-aty0vrat	237	4	degradation	degradation	NN
cord-259237-aty0vrat	237	5	also	also	RB
cord-259237-aty0vrat	237	6	requires	require	VBZ
cord-259237-aty0vrat	237	7	the	the	DT
cord-259237-aty0vrat	237	8	cytosolic	cytosolic	JJ
cord-259237-aty0vrat	237	9	ATPase	ATPase	NNP
cord-259237-aty0vrat	237	10	p97	p97	NN
cord-259237-aty0vrat	237	11	and	and	CC
cord-259237-aty0vrat	237	12	its	-PRON-	PRP$
cord-259237-aty0vrat	237	13	cofactors	cofactor	NNS
cord-259237-aty0vrat	237	14	UFD1L	ufd1l	NN
cord-259237-aty0vrat	237	15	and	and	CC
cord-259237-aty0vrat	237	16	NPL4	NPL4	NNP
cord-259237-aty0vrat	237	17	,	,	,
cord-259237-aty0vrat	237	18	which	which	WDT
cord-259237-aty0vrat	237	19	are	be	VBP
cord-259237-aty0vrat	237	20	key	key	JJ
cord-259237-aty0vrat	237	21	components	component	NNS
cord-259237-aty0vrat	237	22	of	of	IN
cord-259237-aty0vrat	237	23	the	the	DT
cord-259237-aty0vrat	237	24	ERAD	ERAD	NNP
cord-259237-aty0vrat	237	25	machinery	machinery	NN
cord-259237-aty0vrat	237	26	,	,	,
cord-259237-aty0vrat	237	27	suggesting	suggest	VBG
cord-259237-aty0vrat	237	28	that	that	IN
cord-259237-aty0vrat	237	29	CD4	CD4	NNP
cord-259237-aty0vrat	237	30	is	be	VBZ
cord-259237-aty0vrat	237	31	degraded	degrade	VBN
cord-259237-aty0vrat	237	32	via	via	IN
cord-259237-aty0vrat	237	33	ERAD	ERAD	NNP
cord-259237-aty0vrat	237	34	[	[	-LRB-
cord-259237-aty0vrat	237	35	122	122	CD
cord-259237-aty0vrat	237	36	]	]	-RRB-
cord-259237-aty0vrat	237	37	.	.	.
cord-259237-aty0vrat	238	1	Nevertheless	nevertheless	RB
cord-259237-aty0vrat	238	2	,	,	,
cord-259237-aty0vrat	238	3	the	the	DT
cord-259237-aty0vrat	238	4	degradation	degradation	NN
cord-259237-aty0vrat	238	5	is	be	VBZ
cord-259237-aty0vrat	238	6	not	not	RB
cord-259237-aty0vrat	238	7	dependent	dependent	JJ
cord-259237-aty0vrat	238	8	on	on	IN
cord-259237-aty0vrat	238	9	HRD1	HRD1	NNP
cord-259237-aty0vrat	238	10	,	,	,
cord-259237-aty0vrat	238	11	SEL1L	sel1l	JJ
cord-259237-aty0vrat	238	12	,	,	,
cord-259237-aty0vrat	238	13	and	and	CC
cord-259237-aty0vrat	238	14	UBC7	UBC7	NNP
cord-259237-aty0vrat	238	15	.	.	.
cord-259237-aty0vrat	239	1	In	in	IN
cord-259237-aty0vrat	239	2	addition	addition	NN
cord-259237-aty0vrat	239	3	to	to	IN
cord-259237-aty0vrat	239	4	degradation	degradation	NN
cord-259237-aty0vrat	239	5	,	,	,
cord-259237-aty0vrat	239	6	viruses	virus	NNS
cord-259237-aty0vrat	239	7	may	may	MD
cord-259237-aty0vrat	239	8	harness	harness	VB
cord-259237-aty0vrat	239	9	ERAD	ERAD	NNP
cord-259237-aty0vrat	239	10	components	component	NNS
cord-259237-aty0vrat	239	11	to	to	TO
cord-259237-aty0vrat	239	12	benefit	benefit	VB
cord-259237-aty0vrat	239	13	their	-PRON-	PRP$
cord-259237-aty0vrat	239	14	replication	replication	NN
cord-259237-aty0vrat	239	15	.	.	.
cord-259237-aty0vrat	240	1	First	first	RB
cord-259237-aty0vrat	240	2	,	,	,
cord-259237-aty0vrat	240	3	ERAD	ERAD	NNP
cord-259237-aty0vrat	240	4	can	can	MD
cord-259237-aty0vrat	240	5	promote	promote	VB
cord-259237-aty0vrat	240	6	viral	viral	JJ
cord-259237-aty0vrat	240	7	protein	protein	NN
cord-259237-aty0vrat	240	8	expression	expression	NN
cord-259237-aty0vrat	240	9	.	.	.
cord-259237-aty0vrat	241	1	Mouse	mouse	NN
cord-259237-aty0vrat	241	2	mammary	mammary	JJ
cord-259237-aty0vrat	241	3	tumor	tumor	NN
cord-259237-aty0vrat	241	4	virus	virus	NN
cord-259237-aty0vrat	241	5	(	(	-LRB-
cord-259237-aty0vrat	241	6	MMTV	MMTV	NNP
cord-259237-aty0vrat	241	7	)	)	-RRB-
cord-259237-aty0vrat	241	8	is	be	VBZ
cord-259237-aty0vrat	241	9	a	a	DT
cord-259237-aty0vrat	241	10	betaretrovirus	betaretrovirus	NNP
cord-259237-aty0vrat	241	11	,	,	,
cord-259237-aty0vrat	241	12	which	which	WDT
cord-259237-aty0vrat	241	13	expresses	express	VBZ
cord-259237-aty0vrat	241	14	the	the	DT
cord-259237-aty0vrat	241	15	Rem	Rem	NNP
cord-259237-aty0vrat	241	16	protein	protein	NN
cord-259237-aty0vrat	241	17	in	in	IN
cord-259237-aty0vrat	241	18	the	the	DT
cord-259237-aty0vrat	241	19	ER	ER	NNP
cord-259237-aty0vrat	241	20	.	.	.
cord-259237-aty0vrat	242	1	Rem	Rem	NNP
cord-259237-aty0vrat	242	2	has	have	VBZ
cord-259237-aty0vrat	242	3	a	a	DT
cord-259237-aty0vrat	242	4	N	n	CD
cord-259237-aty0vrat	242	5	-	-	HYPH
cord-259237-aty0vrat	242	6	terminal	terminal	JJ
cord-259237-aty0vrat	242	7	98-amino	98-amino	CD
cord-259237-aty0vrat	242	8	acid	acid	NN
cord-259237-aty0vrat	242	9	signal	signal	NN
cord-259237-aty0vrat	242	10	peptide	peptide	NN
cord-259237-aty0vrat	242	11	(	(	-LRB-
cord-259237-aty0vrat	242	12	SP	SP	NNP
cord-259237-aty0vrat	242	13	)	)	-RRB-
cord-259237-aty0vrat	242	14	,	,	,
cord-259237-aty0vrat	242	15	which	which	WDT
cord-259237-aty0vrat	242	16	is	be	VBZ
cord-259237-aty0vrat	242	17	cleaved	cleave	VBN
cord-259237-aty0vrat	242	18	off	off	RP
cord-259237-aty0vrat	242	19	by	by	IN
cord-259237-aty0vrat	242	20	signal	signal	NN
cord-259237-aty0vrat	242	21	peptidase	peptidase	NN
cord-259237-aty0vrat	242	22	and	and	CC
cord-259237-aty0vrat	242	23	retrotranslocated	retrotranslocate	VBD
cord-259237-aty0vrat	242	24	in	in	IN
cord-259237-aty0vrat	242	25	a	a	DT
cord-259237-aty0vrat	242	26	p97-dependent	p97-dependent	CD
cord-259237-aty0vrat	242	27	manner	manner	NN
cord-259237-aty0vrat	242	28	[	[	-LRB-
cord-259237-aty0vrat	242	29	123	123	CD
cord-259237-aty0vrat	242	30	]	]	-RRB-
cord-259237-aty0vrat	242	31	.	.	.
cord-259237-aty0vrat	243	1	Rem	Rem	NNP
cord-259237-aty0vrat	243	2	SP	SP	NNP
cord-259237-aty0vrat	243	3	then	then	RB
cord-259237-aty0vrat	243	4	promotes	promote	VBZ
cord-259237-aty0vrat	243	5	the	the	DT
cord-259237-aty0vrat	243	6	nuclear	nuclear	JJ
cord-259237-aty0vrat	243	7	export	export	NN
cord-259237-aty0vrat	243	8	of	of	IN
cord-259237-aty0vrat	243	9	viral	viral	JJ
cord-259237-aty0vrat	243	10	unspliced	unsplice	VBN
cord-259237-aty0vrat	243	11	RNAs	rna	NNS
cord-259237-aty0vrat	243	12	to	to	IN
cord-259237-aty0vrat	243	13	the	the	DT
cord-259237-aty0vrat	243	14	cytosol	cytosol	NN
cord-259237-aty0vrat	243	15	for	for	IN
cord-259237-aty0vrat	243	16	protein	protein	NN
cord-259237-aty0vrat	243	17	expression	expression	NN
cord-259237-aty0vrat	243	18	.	.	.
cord-259237-aty0vrat	244	1	Similarly	similarly	RB
cord-259237-aty0vrat	244	2	,	,	,
cord-259237-aty0vrat	244	3	hepatitis	hepatitis	NN
cord-259237-aty0vrat	244	4	E	e	NN
cord-259237-aty0vrat	244	5	virus	virus	NN
cord-259237-aty0vrat	244	6	(	(	-LRB-
cord-259237-aty0vrat	244	7	HEV	HEV	NNP
cord-259237-aty0vrat	244	8	)	)	-RRB-
cord-259237-aty0vrat	244	9	ORF2	ORF2	NNP
cord-259237-aty0vrat	244	10	is	be	VBZ
cord-259237-aty0vrat	244	11	an	an	DT
cord-259237-aty0vrat	244	12	N	n	CD
cord-259237-aty0vrat	244	13	-	-	HYPH
cord-259237-aty0vrat	244	14	linked	link	VBN
cord-259237-aty0vrat	244	15	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	244	16	,	,	,
cord-259237-aty0vrat	244	17	but	but	CC
cord-259237-aty0vrat	244	18	functions	function	NNS
cord-259237-aty0vrat	244	19	as	as	IN
cord-259237-aty0vrat	244	20	the	the	DT
cord-259237-aty0vrat	244	21	major	major	JJ
cord-259237-aty0vrat	244	22	capsid	capsid	NN
cord-259237-aty0vrat	244	23	protein	protein	NN
cord-259237-aty0vrat	244	24	.	.	.
cord-259237-aty0vrat	245	1	Although	although	IN
cord-259237-aty0vrat	245	2	ORF2	ORF2	NNP
cord-259237-aty0vrat	245	3	is	be	VBZ
cord-259237-aty0vrat	245	4	expressed	express	VBN
cord-259237-aty0vrat	245	5	in	in	IN
cord-259237-aty0vrat	245	6	the	the	DT
cord-259237-aty0vrat	245	7	ER	ER	NNP
cord-259237-aty0vrat	245	8	,	,	,
cord-259237-aty0vrat	245	9	it	-PRON-	PRP
cord-259237-aty0vrat	245	10	depends	depend	VBZ
cord-259237-aty0vrat	245	11	on	on	IN
cord-259237-aty0vrat	245	12	ERAD	ERAD	NNP
cord-259237-aty0vrat	245	13	components	component	NNS
cord-259237-aty0vrat	245	14	to	to	TO
cord-259237-aty0vrat	245	15	exit	exit	VB
cord-259237-aty0vrat	245	16	from	from	IN
cord-259237-aty0vrat	245	17	the	the	DT
cord-259237-aty0vrat	245	18	ER	ER	NNP
cord-259237-aty0vrat	245	19	to	to	IN
cord-259237-aty0vrat	245	20	the	the	DT
cord-259237-aty0vrat	245	21	cytoplasm	cytoplasm	NN
cord-259237-aty0vrat	245	22	without	without	IN
cord-259237-aty0vrat	245	23	being	be	VBG
cord-259237-aty0vrat	245	24	polyubiquitylated	polyubiquitylate	VBN
cord-259237-aty0vrat	245	25	[	[	-LRB-
cord-259237-aty0vrat	245	26	124	124	CD
cord-259237-aty0vrat	245	27	]	]	-RRB-
cord-259237-aty0vrat	245	28	.	.	.
cord-259237-aty0vrat	246	1	Second	second	JJ
cord-259237-aty0vrat	246	2	,	,	,
cord-259237-aty0vrat	246	3	ERAD	ERAD	NNP
cord-259237-aty0vrat	246	4	can	can	MD
cord-259237-aty0vrat	246	5	promote	promote	VB
cord-259237-aty0vrat	246	6	virus	virus	NN
cord-259237-aty0vrat	246	7	entry	entry	NN
cord-259237-aty0vrat	246	8	.	.	.
cord-259237-aty0vrat	247	1	Polyomaviruses	Polyomaviruses	NNP
cord-259237-aty0vrat	247	2	(	(	-LRB-
cord-259237-aty0vrat	247	3	PyV	PyV	NNP
cord-259237-aty0vrat	247	4	)	)	-RRB-
cord-259237-aty0vrat	247	5	enter	enter	VBP
cord-259237-aty0vrat	247	6	cells	cell	NNS
cord-259237-aty0vrat	247	7	through	through	IN
cord-259237-aty0vrat	247	8	the	the	DT
cord-259237-aty0vrat	247	9	ER	er	NN
cord-259237-aty0vrat	247	10	and	and	CC
cord-259237-aty0vrat	247	11	then	then	RB
cord-259237-aty0vrat	247	12	replicate	replicate	VB
cord-259237-aty0vrat	247	13	in	in	IN
cord-259237-aty0vrat	247	14	the	the	DT
cord-259237-aty0vrat	247	15	nuclei	nucleus	NNS
cord-259237-aty0vrat	247	16	[	[	-LRB-
cord-259237-aty0vrat	247	17	125	125	CD
cord-259237-aty0vrat	247	18	]	]	-RRB-
cord-259237-aty0vrat	247	19	.	.	.
cord-259237-aty0vrat	248	1	To	to	TO
cord-259237-aty0vrat	248	2	get	get	VB
cord-259237-aty0vrat	248	3	from	from	IN
cord-259237-aty0vrat	248	4	the	the	DT
cord-259237-aty0vrat	248	5	ER	ER	NNP
cord-259237-aty0vrat	248	6	to	to	IN
cord-259237-aty0vrat	248	7	the	the	DT
cord-259237-aty0vrat	248	8	nucleus	nucleus	NN
cord-259237-aty0vrat	248	9	,	,	,
cord-259237-aty0vrat	248	10	these	these	DT
cord-259237-aty0vrat	248	11	viruses	virus	NNS
cord-259237-aty0vrat	248	12	can	can	MD
cord-259237-aty0vrat	248	13	cross	cross	VB
cord-259237-aty0vrat	248	14	the	the	DT
cord-259237-aty0vrat	248	15	ER	ER	NNP
cord-259237-aty0vrat	248	16	membrane	membrane	NN
cord-259237-aty0vrat	248	17	into	into	IN
cord-259237-aty0vrat	248	18	the	the	DT
cord-259237-aty0vrat	248	19	cytosol	cytosol	NN
cord-259237-aty0vrat	248	20	via	via	IN
cord-259237-aty0vrat	248	21	the	the	DT
cord-259237-aty0vrat	248	22	ERAD	ERAD	NNP
cord-259237-aty0vrat	248	23	retrotranslocons	retrotranslocon	NNS
cord-259237-aty0vrat	248	24	[	[	-LRB-
cord-259237-aty0vrat	248	25	126	126	CD
cord-259237-aty0vrat	248	26	]	]	-RRB-
cord-259237-aty0vrat	248	27	.	.	.
cord-259237-aty0vrat	249	1	An	an	DT
cord-259237-aty0vrat	249	2	example	example	NN
cord-259237-aty0vrat	249	3	of	of	IN
cord-259237-aty0vrat	249	4	this	this	DT
cord-259237-aty0vrat	249	5	is	be	VBZ
cord-259237-aty0vrat	249	6	mouse	mouse	NN
cord-259237-aty0vrat	249	7	PyV	PyV	NNP
cord-259237-aty0vrat	249	8	,	,	,
cord-259237-aty0vrat	249	9	which	which	WDT
cord-259237-aty0vrat	249	10	uses	use	VBZ
cord-259237-aty0vrat	249	11	Derlin-2	Derlin-2	NNP
cord-259237-aty0vrat	249	12	,	,	,
cord-259237-aty0vrat	249	13	whereas	whereas	IN
cord-259237-aty0vrat	249	14	simian	simian	JJ
cord-259237-aty0vrat	249	15	virus	virus	NN
cord-259237-aty0vrat	249	16	40	40	CD
cord-259237-aty0vrat	249	17	(	(	-LRB-
cord-259237-aty0vrat	249	18	SV40	SV40	NNP
cord-259237-aty0vrat	249	19	)	)	-RRB-
cord-259237-aty0vrat	249	20	uses	use	VBZ
cord-259237-aty0vrat	249	21	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	249	22	and	and	CC
cord-259237-aty0vrat	249	23	the	the	DT
cord-259237-aty0vrat	249	24	SEL1L	sel1l	JJ
cord-259237-aty0vrat	249	25	complex	complex	NN
cord-259237-aty0vrat	249	26	for	for	IN
cord-259237-aty0vrat	249	27	dislocation	dislocation	NN
cord-259237-aty0vrat	249	28	[	[	-LRB-
cord-259237-aty0vrat	249	29	126	126	CD
cord-259237-aty0vrat	249	30	,	,	,
cord-259237-aty0vrat	249	31	127	127	CD
cord-259237-aty0vrat	249	32	]	]	-RRB-
cord-259237-aty0vrat	249	33	.	.	.
cord-259237-aty0vrat	250	1	In	in	IN
cord-259237-aty0vrat	250	2	addition	addition	NN
cord-259237-aty0vrat	250	3	,	,	,
cord-259237-aty0vrat	250	4	the	the	DT
cord-259237-aty0vrat	250	5	proteasome	proteasome	NN
cord-259237-aty0vrat	250	6	machinery	machinery	NN
cord-259237-aty0vrat	250	7	is	be	VBZ
cord-259237-aty0vrat	250	8	also	also	RB
cord-259237-aty0vrat	250	9	required	require	VBN
cord-259237-aty0vrat	250	10	for	for	IN
cord-259237-aty0vrat	250	11	the	the	DT
cord-259237-aty0vrat	250	12	human	human	JJ
cord-259237-aty0vrat	250	13	BK	BK	NNP
cord-259237-aty0vrat	250	14	PyV	PyV	NNP
cord-259237-aty0vrat	250	15	exit	exit	NN
cord-259237-aty0vrat	250	16	from	from	IN
cord-259237-aty0vrat	250	17	the	the	DT
cord-259237-aty0vrat	250	18	ER	ER	NNP
cord-259237-aty0vrat	250	19	[	[	-LRB-
cord-259237-aty0vrat	250	20	127	127	CD
cord-259237-aty0vrat	250	21	]	]	-RRB-
cord-259237-aty0vrat	250	22	.	.	.
cord-259237-aty0vrat	251	1	Third	third	JJ
cord-259237-aty0vrat	251	2	,	,	,
cord-259237-aty0vrat	251	3	ERAD	ERAD	NNP
cord-259237-aty0vrat	251	4	can	can	MD
cord-259237-aty0vrat	251	5	promote	promote	VB
cord-259237-aty0vrat	251	6	virus	virus	NN
cord-259237-aty0vrat	251	7	replication	replication	NN
cord-259237-aty0vrat	251	8	.	.	.
cord-259237-aty0vrat	252	1	The	the	DT
cord-259237-aty0vrat	252	2	replication	replication	NN
cord-259237-aty0vrat	252	3	of	of	IN
cord-259237-aty0vrat	252	4	positive	positive	JJ
cord-259237-aty0vrat	252	5	-	-	HYPH
cord-259237-aty0vrat	252	6	strand	strand	NN
cord-259237-aty0vrat	252	7	RNA	RNA	NNP
cord-259237-aty0vrat	252	8	viruses	virus	NNS
cord-259237-aty0vrat	252	9	normally	normally	RB
cord-259237-aty0vrat	252	10	involves	involve	VBZ
cord-259237-aty0vrat	252	11	the	the	DT
cord-259237-aty0vrat	252	12	formation	formation	NN
cord-259237-aty0vrat	252	13	of	of	IN
cord-259237-aty0vrat	252	14	double	double	JJ
cord-259237-aty0vrat	252	15	-	-	HYPH
cord-259237-aty0vrat	252	16	membrane	membrane	NN
cord-259237-aty0vrat	252	17	vesicles	vesicle	NNS
cord-259237-aty0vrat	252	18	(	(	-LRB-
cord-259237-aty0vrat	252	19	DMVs	DMVs	NNPS
cord-259237-aty0vrat	252	20	)	)	-RRB-
cord-259237-aty0vrat	252	21	and	and	CC
cord-259237-aty0vrat	252	22	convoluted	convoluted	JJ
cord-259237-aty0vrat	252	23	membranes	membrane	NNS
cord-259237-aty0vrat	252	24	(	(	-LRB-
cord-259237-aty0vrat	252	25	CMs	CMs	NNP
cord-259237-aty0vrat	252	26	)	)	-RRB-
cord-259237-aty0vrat	252	27	by	by	IN
cord-259237-aty0vrat	252	28	rearrangement	rearrangement	NN
cord-259237-aty0vrat	252	29	of	of	IN
cord-259237-aty0vrat	252	30	cellular	cellular	JJ
cord-259237-aty0vrat	252	31	membranes	membrane	NNS
cord-259237-aty0vrat	252	32	,	,	,
cord-259237-aty0vrat	252	33	which	which	WDT
cord-259237-aty0vrat	252	34	segregates	segregate	VBZ
cord-259237-aty0vrat	252	35	and	and	CC
cord-259237-aty0vrat	252	36	protects	protect	VBZ
cord-259237-aty0vrat	252	37	viral	viral	JJ
cord-259237-aty0vrat	252	38	proteins	protein	NNS
cord-259237-aty0vrat	252	39	and	and	CC
cord-259237-aty0vrat	252	40	genomes	genome	NNS
cord-259237-aty0vrat	252	41	from	from	IN
cord-259237-aty0vrat	252	42	the	the	DT
cord-259237-aty0vrat	252	43	host	host	NN
cord-259237-aty0vrat	252	44	's	's	POS
cord-259237-aty0vrat	252	45	innate	innate	JJ
cord-259237-aty0vrat	252	46	immune	immune	JJ
cord-259237-aty0vrat	252	47	response	response	NN
cord-259237-aty0vrat	252	48	.	.	.
cord-259237-aty0vrat	253	1	As	as	IN
cord-259237-aty0vrat	253	2	introduced	introduce	VBN
cord-259237-aty0vrat	253	3	earlier	early	RBR
cord-259237-aty0vrat	253	4	,	,	,
cord-259237-aty0vrat	253	5	the	the	DT
cord-259237-aty0vrat	253	6	ERAD	ERAD	NNP
cord-259237-aty0vrat	253	7	activity	activity	NN
cord-259237-aty0vrat	253	8	can	can	MD
cord-259237-aty0vrat	253	9	be	be	VB
cord-259237-aty0vrat	253	10	adjusted	adjust	VBN
cord-259237-aty0vrat	253	11	by	by	IN
cord-259237-aty0vrat	253	12	ERAD	ERAD	NNP
cord-259237-aty0vrat	253	13	tuning	tuning	NN
cord-259237-aty0vrat	253	14	vesicles	vesicle	NNS
cord-259237-aty0vrat	253	15	termed	term	VBN
cord-259237-aty0vrat	253	16	EDEMosomes	edemosome	NNS
cord-259237-aty0vrat	253	17	(	(	-LRB-
cord-259237-aty0vrat	253	18	Figure	figure	NN
cord-259237-aty0vrat	253	19	1B	1b	NN
cord-259237-aty0vrat	253	20	)	)	-RRB-
cord-259237-aty0vrat	253	21	,	,	,
cord-259237-aty0vrat	253	22	which	which	WDT
cord-259237-aty0vrat	253	23	display	display	VBP
cord-259237-aty0vrat	253	24	non	non	JJ
cord-259237-aty0vrat	253	25	-	-	JJ
cord-259237-aty0vrat	253	26	lipidated	lipidated	JJ
cord-259237-aty0vrat	253	27	LC3	lc3	NN
cord-259237-aty0vrat	253	28	and	and	CC
cord-259237-aty0vrat	253	29	segregate	segregate	VB
cord-259237-aty0vrat	253	30	the	the	DT
cord-259237-aty0vrat	253	31	ERAD	ERAD	NNP
cord-259237-aty0vrat	253	32	factors	factor	NNS
cord-259237-aty0vrat	253	33	EDEM1	EDEM1	NNS
cord-259237-aty0vrat	253	34	,	,	,
cord-259237-aty0vrat	253	35	OS-9	OS-9	NNP
cord-259237-aty0vrat	253	36	,	,	,
cord-259237-aty0vrat	253	37	and	and	CC
cord-259237-aty0vrat	253	38	SEL1L	sel1l	JJ
cord-259237-aty0vrat	253	39	from	from	IN
cord-259237-aty0vrat	253	40	the	the	DT
cord-259237-aty0vrat	253	41	ER	ER	NNP
cord-259237-aty0vrat	253	42	lumen	lumen	NN
cord-259237-aty0vrat	253	43	[	[	-LRB-
cord-259237-aty0vrat	253	44	81	81	CD
cord-259237-aty0vrat	253	45	]	]	-RRB-
cord-259237-aty0vrat	253	46	.	.	.
cord-259237-aty0vrat	254	1	By	by	IN
cord-259237-aty0vrat	254	2	comparing	compare	VBG
cord-259237-aty0vrat	254	3	the	the	DT
cord-259237-aty0vrat	254	4	similarity	similarity	NN
cord-259237-aty0vrat	254	5	between	between	IN
cord-259237-aty0vrat	254	6	DMVs	dmv	NNS
cord-259237-aty0vrat	254	7	and	and	CC
cord-259237-aty0vrat	254	8	EDEMosomes	edemosome	NNS
cord-259237-aty0vrat	254	9	,	,	,
cord-259237-aty0vrat	254	10	it	-PRON-	PRP
cord-259237-aty0vrat	254	11	has	have	VBZ
cord-259237-aty0vrat	254	12	been	be	VBN
cord-259237-aty0vrat	254	13	discovered	discover	VBN
cord-259237-aty0vrat	254	14	that	that	IN
cord-259237-aty0vrat	254	15	mouse	mouse	NN
cord-259237-aty0vrat	254	16	hepatitis	hepatitis	NN
cord-259237-aty0vrat	254	17	virus	virus	NN
cord-259237-aty0vrat	254	18	(	(	-LRB-
cord-259237-aty0vrat	254	19	MHV	MHV	NNP
cord-259237-aty0vrat	254	20	)	)	-RRB-
cord-259237-aty0vrat	254	21	,	,	,
cord-259237-aty0vrat	254	22	equine	equine	JJ
cord-259237-aty0vrat	254	23	arteritis	arteritis	NN
cord-259237-aty0vrat	254	24	virus	virus	NN
cord-259237-aty0vrat	254	25	(	(	-LRB-
cord-259237-aty0vrat	254	26	EAV	EAV	NNP
cord-259237-aty0vrat	254	27	)	)	-RRB-
cord-259237-aty0vrat	254	28	,	,	,
cord-259237-aty0vrat	254	29	and	and	CC
cord-259237-aty0vrat	254	30	JEV	JEV	NNP
cord-259237-aty0vrat	254	31	indeed	indeed	RB
cord-259237-aty0vrat	254	32	replicate	replicate	VBP
cord-259237-aty0vrat	254	33	in	in	IN
cord-259237-aty0vrat	254	34	these	these	DT
cord-259237-aty0vrat	254	35	ERAD	ERAD	NNP
cord-259237-aty0vrat	254	36	tuning	tuning	NN
cord-259237-aty0vrat	254	37	vesicles	vesicle	NNS
cord-259237-aty0vrat	254	38	[	[	-LRB-
cord-259237-aty0vrat	254	39	128	128	CD
cord-259237-aty0vrat	254	40	]	]	-RRB-
cord-259237-aty0vrat	254	41	.	.	.
cord-259237-aty0vrat	255	1	Thus	thus	RB
cord-259237-aty0vrat	255	2	,	,	,
cord-259237-aty0vrat	255	3	these	these	DT
cord-259237-aty0vrat	255	4	viruses	virus	NNS
cord-259237-aty0vrat	255	5	can	can	MD
cord-259237-aty0vrat	255	6	subvert	subvert	VB
cord-259237-aty0vrat	255	7	EDEMosomes	edemosome	NNS
cord-259237-aty0vrat	255	8	as	as	IN
cord-259237-aty0vrat	255	9	their	-PRON-	PRP$
cord-259237-aty0vrat	255	10	replication	replication	NN
cord-259237-aty0vrat	255	11	vesicles	vesicle	NNS
cord-259237-aty0vrat	255	12	to	to	TO
cord-259237-aty0vrat	255	13	promote	promote	VB
cord-259237-aty0vrat	255	14	infection	infection	NN
cord-259237-aty0vrat	255	15	[	[	-LRB-
cord-259237-aty0vrat	255	16	129	129	CD
cord-259237-aty0vrat	255	17	]	]	-RRB-
cord-259237-aty0vrat	255	18	.	.	.
cord-259237-aty0vrat	256	1	Although	although	IN
cord-259237-aty0vrat	256	2	ERAD	ERAD	NNP
cord-259237-aty0vrat	256	3	has	have	VBZ
cord-259237-aty0vrat	256	4	been	be	VBN
cord-259237-aty0vrat	256	5	frequently	frequently	RB
cord-259237-aty0vrat	256	6	manipulated	manipulate	VBN
cord-259237-aty0vrat	256	7	by	by	IN
cord-259237-aty0vrat	256	8	a	a	DT
cord-259237-aty0vrat	256	9	number	number	NN
cord-259237-aty0vrat	256	10	of	of	IN
cord-259237-aty0vrat	256	11	viruses	virus	NNS
cord-259237-aty0vrat	256	12	to	to	TO
cord-259237-aty0vrat	256	13	promote	promote	VB
cord-259237-aty0vrat	256	14	infection	infection	NN
cord-259237-aty0vrat	256	15	or	or	CC
cord-259237-aty0vrat	256	16	attenuate	attenuate	VB
cord-259237-aty0vrat	256	17	immune	immune	JJ
cord-259237-aty0vrat	256	18	responses	response	NNS
cord-259237-aty0vrat	256	19	,	,	,
cord-259237-aty0vrat	256	20	it	-PRON-	PRP
cord-259237-aty0vrat	256	21	may	may	MD
cord-259237-aty0vrat	256	22	also	also	RB
cord-259237-aty0vrat	256	23	function	function	VB
cord-259237-aty0vrat	256	24	directly	directly	RB
cord-259237-aty0vrat	256	25	as	as	IN
cord-259237-aty0vrat	256	26	an	an	DT
cord-259237-aty0vrat	256	27	antiviral	antiviral	JJ
cord-259237-aty0vrat	256	28	device	device	NN
cord-259237-aty0vrat	256	29	to	to	TO
cord-259237-aty0vrat	256	30	protect	protect	VB
cord-259237-aty0vrat	256	31	host	host	NN
cord-259237-aty0vrat	256	32	cells	cell	NNS
cord-259237-aty0vrat	256	33	from	from	IN
cord-259237-aty0vrat	256	34	infection	infection	NN
cord-259237-aty0vrat	256	35	.	.	.
cord-259237-aty0vrat	257	1	Because	because	IN
cord-259237-aty0vrat	257	2	viral	viral	JJ
cord-259237-aty0vrat	257	3	envelope	envelope	NN
cord-259237-aty0vrat	257	4	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	257	5	production	production	NN
cord-259237-aty0vrat	257	6	and	and	CC
cord-259237-aty0vrat	257	7	folding	folding	NN
cord-259237-aty0vrat	257	8	take	take	VBP
cord-259237-aty0vrat	257	9	place	place	NN
cord-259237-aty0vrat	257	10	in	in	IN
cord-259237-aty0vrat	257	11	the	the	DT
cord-259237-aty0vrat	257	12	ER	ER	NNP
cord-259237-aty0vrat	257	13	,	,	,
cord-259237-aty0vrat	257	14	these	these	DT
cord-259237-aty0vrat	257	15	viral	viral	JJ
cord-259237-aty0vrat	257	16	proteins	protein	NNS
cord-259237-aty0vrat	257	17	may	may	MD
cord-259237-aty0vrat	257	18	become	become	VB
cord-259237-aty0vrat	257	19	the	the	DT
cord-259237-aty0vrat	257	20	primary	primary	JJ
cord-259237-aty0vrat	257	21	targets	target	NNS
cord-259237-aty0vrat	257	22	for	for	IN
cord-259237-aty0vrat	257	23	ERAD	ERAD	NNP
cord-259237-aty0vrat	257	24	,	,	,
cord-259237-aty0vrat	257	25	resulting	result	VBG
cord-259237-aty0vrat	257	26	in	in	IN
cord-259237-aty0vrat	257	27	the	the	DT
cord-259237-aty0vrat	257	28	inhibition	inhibition	NN
cord-259237-aty0vrat	257	29	of	of	IN
cord-259237-aty0vrat	257	30	viral	viral	JJ
cord-259237-aty0vrat	257	31	infection	infection	NN
cord-259237-aty0vrat	257	32	.	.	.
cord-259237-aty0vrat	258	1	Primate	primate	JJ
cord-259237-aty0vrat	258	2	lentiviruses	lentiviruse	NNS
cord-259237-aty0vrat	258	3	,	,	,
cord-259237-aty0vrat	258	4	including	include	VBG
cord-259237-aty0vrat	258	5	HIV	HIV	NNP
cord-259237-aty0vrat	258	6	and	and	CC
cord-259237-aty0vrat	258	7	SIV	SIV	NNP
cord-259237-aty0vrat	258	8	,	,	,
cord-259237-aty0vrat	258	9	have	have	VBP
cord-259237-aty0vrat	258	10	low	low	JJ
cord-259237-aty0vrat	258	11	levels	level	NNS
cord-259237-aty0vrat	258	12	of	of	IN
cord-259237-aty0vrat	258	13	envelope	envelope	NN
cord-259237-aty0vrat	258	14	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	258	15	on	on	IN
cord-259237-aty0vrat	258	16	their	-PRON-	PRP$
cord-259237-aty0vrat	258	17	surface	surface	NN
cord-259237-aty0vrat	258	18	,	,	,
cord-259237-aty0vrat	258	19	and	and	CC
cord-259237-aty0vrat	258	20	the	the	DT
cord-259237-aty0vrat	258	21	average	average	JJ
cord-259237-aty0vrat	258	22	copy	copy	NN
cord-259237-aty0vrat	258	23	number	number	NN
cord-259237-aty0vrat	258	24	is~14	is~14	NNP
cord-259237-aty0vrat	258	25	Env	Env	NNP
cord-259237-aty0vrat	258	26	trimers	trimer	NNS
cord-259237-aty0vrat	258	27	per	per	IN
cord-259237-aty0vrat	258	28	virion	virion	NN
cord-259237-aty0vrat	258	29	[	[	-LRB-
cord-259237-aty0vrat	258	30	130	130	CD
cord-259237-aty0vrat	258	31	,	,	,
cord-259237-aty0vrat	258	32	131	131	CD
cord-259237-aty0vrat	258	33	]	]	-RRB-
cord-259237-aty0vrat	258	34	.	.	.
cord-259237-aty0vrat	259	1	In	in	IN
cord-259237-aty0vrat	259	2	contrast	contrast	NN
cord-259237-aty0vrat	259	3	,	,	,
cord-259237-aty0vrat	259	4	IFA	IFA	NNP
cord-259237-aty0vrat	259	5	,	,	,
cord-259237-aty0vrat	259	6	Sendai	Sendai	NNP
cord-259237-aty0vrat	259	7	virus	virus	NN
cord-259237-aty0vrat	259	8	,	,	,
cord-259237-aty0vrat	259	9	HSV	HSV	NNP
cord-259237-aty0vrat	259	10	,	,	,
cord-259237-aty0vrat	259	11	and	and	CC
cord-259237-aty0vrat	259	12	Moloney	Moloney	NNP
cord-259237-aty0vrat	259	13	murine	murine	JJ
cord-259237-aty0vrat	259	14	leukemia	leukemia	NN
cord-259237-aty0vrat	259	15	virus	virus	NN
cord-259237-aty0vrat	259	16	(	(	-LRB-
cord-259237-aty0vrat	259	17	MoMuLV	MoMuLV	NNP
cord-259237-aty0vrat	259	18	)	)	-RRB-
cord-259237-aty0vrat	259	19	have	have	VBP
cord-259237-aty0vrat	259	20	much	much	RB
cord-259237-aty0vrat	259	21	more	more	JJR
cord-259237-aty0vrat	259	22	envelope	envelope	NN
cord-259237-aty0vrat	259	23	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	259	24	on	on	IN
cord-259237-aty0vrat	259	25	their	-PRON-	PRP$
cord-259237-aty0vrat	259	26	surfaces	surface	NNS
cord-259237-aty0vrat	259	27	[	[	-LRB-
cord-259237-aty0vrat	259	28	132	132	CD
cord-259237-aty0vrat	259	29	]	]	-RRB-
cord-259237-aty0vrat	259	30	[	[	-LRB-
cord-259237-aty0vrat	259	31	133	133	CD
cord-259237-aty0vrat	259	32	]	]	-RRB-
cord-259237-aty0vrat	259	33	[	[	-LRB-
cord-259237-aty0vrat	259	34	134	134	CD
cord-259237-aty0vrat	259	35	]	]	-RRB-
cord-259237-aty0vrat	259	36	[	[	-LRB-
cord-259237-aty0vrat	259	37	135	135	CD
cord-259237-aty0vrat	259	38	]	]	-RRB-
cord-259237-aty0vrat	259	39	.	.	.
cord-259237-aty0vrat	260	1	The	the	DT
cord-259237-aty0vrat	260	2	exceptionally	exceptionally	RB
cord-259237-aty0vrat	260	3	low	low	JJ
cord-259237-aty0vrat	260	4	number	number	NN
cord-259237-aty0vrat	260	5	of	of	IN
cord-259237-aty0vrat	260	6	Env	Env	NNP
cord-259237-aty0vrat	260	7	spikes	spike	NNS
cord-259237-aty0vrat	260	8	may	may	MD
cord-259237-aty0vrat	260	9	protect	protect	VB
cord-259237-aty0vrat	260	10	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	260	11	from	from	IN
cord-259237-aty0vrat	260	12	host	host	NN
cord-259237-aty0vrat	260	13	immune	immune	JJ
cord-259237-aty0vrat	260	14	responses	response	NNS
cord-259237-aty0vrat	260	15	[	[	-LRB-
cord-259237-aty0vrat	260	16	136	136	CD
cord-259237-aty0vrat	260	17	]	]	-RRB-
cord-259237-aty0vrat	260	18	since	since	IN
cord-259237-aty0vrat	260	19	almost	almost	RB
cord-259237-aty0vrat	260	20	85	85	CD
cord-259237-aty0vrat	260	21	%	%	NN
cord-259237-aty0vrat	260	22	of	of	IN
cord-259237-aty0vrat	260	23	Env	Env	NNP
cord-259237-aty0vrat	260	24	proteins	protein	NNS
cord-259237-aty0vrat	260	25	are	be	VBP
cord-259237-aty0vrat	260	26	retained	retain	VBN
cord-259237-aty0vrat	260	27	in	in	IN
cord-259237-aty0vrat	260	28	the	the	DT
cord-259237-aty0vrat	260	29	ER	ER	NNP
cord-259237-aty0vrat	260	30	and	and	CC
cord-259237-aty0vrat	260	31	are	be	VBP
cord-259237-aty0vrat	260	32	degraded	degrade	VBN
cord-259237-aty0vrat	260	33	[	[	-LRB-
cord-259237-aty0vrat	260	34	137	137	CD
cord-259237-aty0vrat	260	35	]	]	-RRB-
cord-259237-aty0vrat	261	1	[	[	-LRB-
cord-259237-aty0vrat	261	2	138	138	CD
cord-259237-aty0vrat	261	3	]	]	-RRB-
cord-259237-aty0vrat	261	4	[	[	-LRB-
cord-259237-aty0vrat	261	5	139	139	CD
cord-259237-aty0vrat	261	6	]	]	-RRB-
cord-259237-aty0vrat	261	7	.	.	.
cord-259237-aty0vrat	262	1	This	this	DT
cord-259237-aty0vrat	262	2	degradation	degradation	NN
cord-259237-aty0vrat	262	3	mechanism	mechanism	NN
cord-259237-aty0vrat	262	4	was	be	VBD
cord-259237-aty0vrat	262	5	not	not	RB
cord-259237-aty0vrat	262	6	clear	clear	JJ
cord-259237-aty0vrat	262	7	until	until	IN
cord-259237-aty0vrat	262	8	we	-PRON-	PRP
cord-259237-aty0vrat	262	9	recently	recently	RB
cord-259237-aty0vrat	262	10	reported	report	VBD
cord-259237-aty0vrat	262	11	that	that	IN
cord-259237-aty0vrat	262	12	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	262	13	Env	Env	NNP
cord-259237-aty0vrat	262	14	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	262	15	are	be	VBP
cord-259237-aty0vrat	262	16	targeted	target	VBN
cord-259237-aty0vrat	262	17	for	for	IN
cord-259237-aty0vrat	262	18	ERAD	ERAD	NNP
cord-259237-aty0vrat	262	19	.	.	.
cord-259237-aty0vrat	263	1	From	from	IN
cord-259237-aty0vrat	263	2	completely	completely	RB
cord-259237-aty0vrat	263	3	unrelated	unrelated	JJ
cord-259237-aty0vrat	263	4	studies	study	NNS
cord-259237-aty0vrat	263	5	,	,	,
cord-259237-aty0vrat	263	6	we	-PRON-	PRP
cord-259237-aty0vrat	263	7	isolated	isolate	VBD
cord-259237-aty0vrat	263	8	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	263	9	non	non	JJ
cord-259237-aty0vrat	263	10	-	-	JJ
cord-259237-aty0vrat	263	11	permissive	permissive	JJ
cord-259237-aty0vrat	263	12	(	(	-LRB-
cord-259237-aty0vrat	263	13	NP	NP	NNP
cord-259237-aty0vrat	263	14	)	)	-RRB-
cord-259237-aty0vrat	263	15	and	and	CC
cord-259237-aty0vrat	263	16	permissive	permissive	JJ
cord-259237-aty0vrat	263	17	(	(	-LRB-
cord-259237-aty0vrat	263	18	P	p	NN
cord-259237-aty0vrat	263	19	)	)	-RRB-
cord-259237-aty0vrat	263	20	T	t	NN
cord-259237-aty0vrat	263	21	cell	cell	NN
cord-259237-aty0vrat	263	22	clones	clone	NNS
cord-259237-aty0vrat	263	23	N2-NP	n2-np	JJ
cord-259237-aty0vrat	263	24	and	and	CC
cord-259237-aty0vrat	263	25	N5-P	N5-P	NNP
cord-259237-aty0vrat	263	26	from	from	IN
cord-259237-aty0vrat	263	27	the	the	DT
cord-259237-aty0vrat	263	28	original	original	JJ
cord-259237-aty0vrat	263	29	CEM.NKR	CEM.NKR	NNP
cord-259237-aty0vrat	263	30	human	human	JJ
cord-259237-aty0vrat	263	31	T	t	NN
cord-259237-aty0vrat	263	32	cell	cell	NN
cord-259237-aty0vrat	263	33	line	line	NN
cord-259237-aty0vrat	263	34	[	[	-LRB-
cord-259237-aty0vrat	263	35	140	140	CD
cord-259237-aty0vrat	263	36	]	]	-RRB-
cord-259237-aty0vrat	263	37	.	.	.
cord-259237-aty0vrat	264	1	Our	-PRON-	PRP$
cord-259237-aty0vrat	264	2	initial	initial	JJ
cord-259237-aty0vrat	264	3	analysis	analysis	NN
cord-259237-aty0vrat	264	4	uncovered	uncover	VBD
cord-259237-aty0vrat	264	5	that	that	IN
cord-259237-aty0vrat	264	6	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	264	7	replication	replication	NN
cord-259237-aty0vrat	264	8	is	be	VBZ
cord-259237-aty0vrat	264	9	restricted	restrict	VBN
cord-259237-aty0vrat	264	10	from	from	IN
cord-259237-aty0vrat	264	11	the	the	DT
cord-259237-aty0vrat	264	12	second	second	JJ
cord-259237-aty0vrat	264	13	round	round	NN
cord-259237-aty0vrat	264	14	of	of	IN
cord-259237-aty0vrat	264	15	the	the	DT
cord-259237-aty0vrat	264	16	viral	viral	JJ
cord-259237-aty0vrat	264	17	life	life	NN
cord-259237-aty0vrat	264	18	cycle	cycle	NN
cord-259237-aty0vrat	264	19	in	in	IN
cord-259237-aty0vrat	264	20	N2-NP	N2-NP	NNP
cord-259237-aty0vrat	264	21	cells	cell	NNS
cord-259237-aty0vrat	264	22	,	,	,
cord-259237-aty0vrat	264	23	resulting	result	VBG
cord-259237-aty0vrat	264	24	in~1000-fold	in~1000-fold	JJ
cord-259237-aty0vrat	264	25	inhibition	inhibition	NN
cord-259237-aty0vrat	264	26	when	when	WRB
cord-259237-aty0vrat	264	27	compared	compare	VBN
cord-259237-aty0vrat	264	28	to	to	IN
cord-259237-aty0vrat	264	29	N5-P.	N5-P.	NNP
cord-259237-aty0vrat	264	30	Further	further	JJ
cord-259237-aty0vrat	264	31	transcriptome	transcriptome	NN
cord-259237-aty0vrat	264	32	analysis	analysis	NN
cord-259237-aty0vrat	264	33	by	by	IN
cord-259237-aty0vrat	264	34	microarrays	microarray	NNS
cord-259237-aty0vrat	264	35	revealed	reveal	VBD
cord-259237-aty0vrat	264	36	that	that	IN
cord-259237-aty0vrat	264	37	N2-NP	N2-NP	NNP
cord-259237-aty0vrat	264	38	cells	cell	NNS
cord-259237-aty0vrat	264	39	overexpress	overexpress	VBP
cord-259237-aty0vrat	264	40	the	the	DT
cord-259237-aty0vrat	264	41	mitochondrial	mitochondrial	JJ
cord-259237-aty0vrat	264	42	translocator	translocator	NN
cord-259237-aty0vrat	264	43	protein	protein	NN
cord-259237-aty0vrat	264	44	(	(	-LRB-
cord-259237-aty0vrat	264	45	TSPO	TSPO	NNP
cord-259237-aty0vrat	264	46	)	)	-RRB-
cord-259237-aty0vrat	264	47	,	,	,
cord-259237-aty0vrat	264	48	which	which	WDT
cord-259237-aty0vrat	264	49	strongly	strongly	RB
cord-259237-aty0vrat	264	50	inhibits	inhibit	VBZ
cord-259237-aty0vrat	264	51	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	264	52	Env	Env	NNP
cord-259237-aty0vrat	264	53	expression	expression	NN
cord-259237-aty0vrat	264	54	[	[	-LRB-
cord-259237-aty0vrat	264	55	141	141	CD
cord-259237-aty0vrat	264	56	]	]	-RRB-
cord-259237-aty0vrat	264	57	.	.	.
cord-259237-aty0vrat	265	1	TSPO	TSPO	NNP
cord-259237-aty0vrat	265	2	interacts	interact	VBZ
cord-259237-aty0vrat	265	3	with	with	IN
cord-259237-aty0vrat	265	4	the	the	DT
cord-259237-aty0vrat	265	5	mitochondrial	mitochondrial	JJ
cord-259237-aty0vrat	265	6	permeability	permeability	NN
cord-259237-aty0vrat	265	7	transition	transition	NN
cord-259237-aty0vrat	265	8	pore	pore	NN
cord-259237-aty0vrat	265	9	(	(	-LRB-
cord-259237-aty0vrat	265	10	mPTP	mPTP	NNP
cord-259237-aty0vrat	265	11	)	)	-RRB-
cord-259237-aty0vrat	265	12	complex	complex	NNP
cord-259237-aty0vrat	265	13	,	,	,
cord-259237-aty0vrat	265	14	which	which	WDT
cord-259237-aty0vrat	265	15	includes	include	VBZ
cord-259237-aty0vrat	265	16	the	the	DT
cord-259237-aty0vrat	265	17	outer	outer	JJ
cord-259237-aty0vrat	265	18	membrane	membrane	NN
cord-259237-aty0vrat	265	19	protein	protein	NN
cord-259237-aty0vrat	265	20	voltage	voltage	NN
cord-259237-aty0vrat	265	21	-	-	HYPH
cord-259237-aty0vrat	265	22	dependent	dependent	JJ
cord-259237-aty0vrat	265	23	anion	anion	NN
cord-259237-aty0vrat	265	24	channel	channel	NN
cord-259237-aty0vrat	265	25	(	(	-LRB-
cord-259237-aty0vrat	265	26	VDAC	VDAC	NNP
cord-259237-aty0vrat	265	27	)	)	-RRB-
cord-259237-aty0vrat	265	28	protein	protein	NN
cord-259237-aty0vrat	265	29	,	,	,
cord-259237-aty0vrat	265	30	the	the	DT
cord-259237-aty0vrat	265	31	inner	inner	JJ
cord-259237-aty0vrat	265	32	membrane	membrane	NN
cord-259237-aty0vrat	265	33	protein	protein	NN
cord-259237-aty0vrat	265	34	adenine	adenine	NN
cord-259237-aty0vrat	265	35	nucleotide	nucleotide	JJ
cord-259237-aty0vrat	265	36	translocase	translocase	NN
cord-259237-aty0vrat	265	37	(	(	-LRB-
cord-259237-aty0vrat	265	38	ANT	ANT	NNP
cord-259237-aty0vrat	265	39	)	)	-RRB-
cord-259237-aty0vrat	265	40	,	,	,
cord-259237-aty0vrat	265	41	and	and	CC
cord-259237-aty0vrat	265	42	the	the	DT
cord-259237-aty0vrat	265	43	mitochondrial	mitochondrial	JJ
cord-259237-aty0vrat	265	44	matrix	matrix	NN
cord-259237-aty0vrat	265	45	protein	protein	NN
cord-259237-aty0vrat	265	46	cyclophilin	cyclophilin	NNP
cord-259237-aty0vrat	265	47	D	D	NNP
cord-259237-aty0vrat	265	48	(	(	-LRB-
cord-259237-aty0vrat	265	49	CypD	CypD	NNP
cord-259237-aty0vrat	265	50	)	)	-RRB-
cord-259237-aty0vrat	265	51	[	[	-LRB-
cord-259237-aty0vrat	265	52	142	142	CD
cord-259237-aty0vrat	265	53	]	]	-RRB-
cord-259237-aty0vrat	265	54	.	.	.
cord-259237-aty0vrat	266	1	TSPO	TSPO	NNP
cord-259237-aty0vrat	266	2	binds	bind	VBZ
cord-259237-aty0vrat	266	3	to	to	IN
cord-259237-aty0vrat	266	4	VDAC	VDAC	NNP
cord-259237-aty0vrat	266	5	and	and	CC
cord-259237-aty0vrat	266	6	contributes	contribute	VBZ
cord-259237-aty0vrat	266	7	to	to	IN
cord-259237-aty0vrat	266	8	the	the	DT
cord-259237-aty0vrat	266	9	regulation	regulation	NN
cord-259237-aty0vrat	266	10	of	of	IN
cord-259237-aty0vrat	266	11	the	the	DT
cord-259237-aty0vrat	266	12	mitochondrial	mitochondrial	JJ
cord-259237-aty0vrat	266	13	membrane	membrane	NN
cord-259237-aty0vrat	266	14	permeability	permeability	NN
cord-259237-aty0vrat	266	15	by	by	IN
cord-259237-aty0vrat	266	16	the	the	DT
cord-259237-aty0vrat	266	17	mPTP	mptp	JJ
cord-259237-aty0vrat	266	18	complex	complex	NN
cord-259237-aty0vrat	266	19	[	[	-LRB-
cord-259237-aty0vrat	266	20	143	143	CD
cord-259237-aty0vrat	266	21	]	]	-RRB-
cord-259237-aty0vrat	266	22	.	.	.
cord-259237-aty0vrat	267	1	Our	-PRON-	PRP$
cord-259237-aty0vrat	267	2	results	result	NNS
cord-259237-aty0vrat	267	3	suggested	suggest	VBD
cord-259237-aty0vrat	267	4	that	that	IN
cord-259237-aty0vrat	267	5	TSPO	TSPO	NNP
cord-259237-aty0vrat	267	6	overexpression	overexpression	NN
cord-259237-aty0vrat	267	7	could	could	MD
cord-259237-aty0vrat	267	8	reduce	reduce	VB
cord-259237-aty0vrat	267	9	the	the	DT
cord-259237-aty0vrat	267	10	oxidative	oxidative	JJ
cord-259237-aty0vrat	267	11	redox	redox	NN
cord-259237-aty0vrat	267	12	status	status	NN
cord-259237-aty0vrat	267	13	in	in	IN
cord-259237-aty0vrat	267	14	the	the	DT
cord-259237-aty0vrat	267	15	ER	er	NN
cord-259237-aty0vrat	267	16	,	,	,
cord-259237-aty0vrat	267	17	which	which	WDT
cord-259237-aty0vrat	267	18	interferes	interfere	VBZ
cord-259237-aty0vrat	267	19	with	with	IN
cord-259237-aty0vrat	267	20	the	the	DT
cord-259237-aty0vrat	267	21	Env	Env	NNP
cord-259237-aty0vrat	267	22	oxidative	oxidative	JJ
cord-259237-aty0vrat	267	23	folding	folding	NN
cord-259237-aty0vrat	267	24	process	process	NN
cord-259237-aty0vrat	267	25	,	,	,
cord-259237-aty0vrat	267	26	resulting	result	VBG
cord-259237-aty0vrat	267	27	in	in	IN
cord-259237-aty0vrat	267	28	Env	Env	NNP
cord-259237-aty0vrat	267	29	degradation	degradation	NN
cord-259237-aty0vrat	267	30	.	.	.
cord-259237-aty0vrat	268	1	Consistently	consistently	RB
cord-259237-aty0vrat	268	2	,	,	,
cord-259237-aty0vrat	268	3	the	the	DT
cord-259237-aty0vrat	268	4	rapid	rapid	JJ
cord-259237-aty0vrat	268	5	Env	Env	NNP
cord-259237-aty0vrat	268	6	degradation	degradation	NN
cord-259237-aty0vrat	268	7	in	in	IN
cord-259237-aty0vrat	268	8	N2-NP	N2-NP	NNP
cord-259237-aty0vrat	268	9	cells	cell	NNS
cord-259237-aty0vrat	268	10	was	be	VBD
cord-259237-aty0vrat	268	11	rescued	rescue	VBN
cord-259237-aty0vrat	268	12	by	by	IN
cord-259237-aty0vrat	268	13	kifunesine	kifunesine	NNP
cord-259237-aty0vrat	268	14	,	,	,
cord-259237-aty0vrat	268	15	an	an	DT
cord-259237-aty0vrat	268	16	effective	effective	JJ
cord-259237-aty0vrat	268	17	inhibitor	inhibitor	NN
cord-259237-aty0vrat	268	18	of	of	IN
cord-259237-aty0vrat	268	19	glycoside	glycoside	NN
cord-259237-aty0vrat	268	20	hydrolase	hydrolase	NNP
cord-259237-aty0vrat	268	21	family	family	NN
cord-259237-aty0vrat	268	22	47	47	CD
cord-259237-aty0vrat	269	1	(	(	-LRB-
cord-259237-aty0vrat	269	2	GH47	GH47	NNP
cord-259237-aty0vrat	269	3	)	)	-RRB-
cord-259237-aty0vrat	269	4	enzymes	enzyme	NNS
cord-259237-aty0vrat	269	5	[	[	-LRB-
cord-259237-aty0vrat	269	6	144	144	CD
cord-259237-aty0vrat	269	7	]	]	-RRB-
cord-259237-aty0vrat	269	8	,	,	,
cord-259237-aty0vrat	269	9	suggesting	suggest	VBG
cord-259237-aty0vrat	269	10	that	that	IN
cord-259237-aty0vrat	269	11	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	269	12	is	be	VBZ
cord-259237-aty0vrat	269	13	degraded	degrade	VBN
cord-259237-aty0vrat	269	14	via	via	IN
cord-259237-aty0vrat	269	15	ERAD	ERAD	NNP
cord-259237-aty0vrat	269	16	in	in	IN
cord-259237-aty0vrat	269	17	N2-NP	N2-NP	NNP
cord-259237-aty0vrat	269	18	cells	cell	NNS
cord-259237-aty0vrat	269	19	.	.	.
cord-259237-aty0vrat	270	1	To	to	TO
cord-259237-aty0vrat	270	2	further	further	RB
cord-259237-aty0vrat	270	3	explore	explore	VB
cord-259237-aty0vrat	270	4	the	the	DT
cord-259237-aty0vrat	270	5	Env	Env	NNP
cord-259237-aty0vrat	270	6	degradation	degradation	NN
cord-259237-aty0vrat	270	7	mechanism	mechanism	NN
cord-259237-aty0vrat	270	8	,	,	,
cord-259237-aty0vrat	270	9	we	-PRON-	PRP
cord-259237-aty0vrat	270	10	investigated	investigate	VBD
cord-259237-aty0vrat	270	11	which	which	WDT
cord-259237-aty0vrat	270	12	of	of	IN
cord-259237-aty0vrat	270	13	those	those	DT
cord-259237-aty0vrat	270	14	four	four	CD
cord-259237-aty0vrat	270	15	ER	ER	NNP
cord-259237-aty0vrat	270	16	-	-	HYPH
cord-259237-aty0vrat	270	17	associated	associate	VBN
cord-259237-aty0vrat	270	18	GH47	GH47	NNP
cord-259237-aty0vrat	270	19	enzymes	enzyme	NNS
cord-259237-aty0vrat	270	20	was	be	VBD
cord-259237-aty0vrat	270	21	responsible	responsible	JJ
cord-259237-aty0vrat	270	22	for	for	IN
cord-259237-aty0vrat	270	23	the	the	DT
cord-259237-aty0vrat	270	24	Env	Env	NNP
cord-259237-aty0vrat	270	25	degradation	degradation	NN
cord-259237-aty0vrat	270	26	.	.	.
cord-259237-aty0vrat	271	1	Notably	notably	RB
cord-259237-aty0vrat	271	2	,	,	,
cord-259237-aty0vrat	271	3	when	when	WRB
cord-259237-aty0vrat	271	4	ERManI	ERManI	NNP
cord-259237-aty0vrat	271	5	,	,	,
cord-259237-aty0vrat	271	6	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	271	7	,	,	,
cord-259237-aty0vrat	271	8	EDEM2	EDEM2	NNP
cord-259237-aty0vrat	271	9	,	,	,
cord-259237-aty0vrat	271	10	and	and	CC
cord-259237-aty0vrat	271	11	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	271	12	were	be	VBD
cord-259237-aty0vrat	271	13	ectopically	ectopically	RB
cord-259237-aty0vrat	271	14	expressed	express	VBN
cord-259237-aty0vrat	271	15	in	in	IN
cord-259237-aty0vrat	271	16	293	293	CD
cord-259237-aty0vrat	271	17	T	T	NNP
cord-259237-aty0vrat	271	18	cells	cell	NNS
cord-259237-aty0vrat	271	19	,	,	,
cord-259237-aty0vrat	271	20	only	only	RB
cord-259237-aty0vrat	271	21	ERManI	ERManI	NNP
cord-259237-aty0vrat	271	22	strongly	strongly	RB
cord-259237-aty0vrat	271	23	inhibited	inhibit	VBD
cord-259237-aty0vrat	271	24	Env	env	JJ
cord-259237-aty0vrat	271	25	expression	expression	NN
cord-259237-aty0vrat	271	26	in	in	IN
cord-259237-aty0vrat	271	27	a	a	DT
cord-259237-aty0vrat	271	28	dose	dose	NN
cord-259237-aty0vrat	271	29	-	-	HYPH
cord-259237-aty0vrat	271	30	dependent	dependent	JJ
cord-259237-aty0vrat	271	31	manner	manner	NN
cord-259237-aty0vrat	271	32	.	.	.
cord-259237-aty0vrat	272	1	In	in	IN
cord-259237-aty0vrat	272	2	addition	addition	NN
cord-259237-aty0vrat	272	3	,	,	,
cord-259237-aty0vrat	272	4	when	when	WRB
cord-259237-aty0vrat	272	5	the	the	DT
cord-259237-aty0vrat	272	6	endogenous	endogenous	JJ
cord-259237-aty0vrat	272	7	ERManI	ERManI	NNP
cord-259237-aty0vrat	272	8	was	be	VBD
cord-259237-aty0vrat	272	9	knocked	knock	VBN
cord-259237-aty0vrat	272	10	out	out	RP
cord-259237-aty0vrat	272	11	by	by	IN
cord-259237-aty0vrat	272	12	CRISPR	CRISPR	NNP
cord-259237-aty0vrat	272	13	/	/	SYM
cord-259237-aty0vrat	272	14	Cas9	Cas9	NNP
cord-259237-aty0vrat	272	15	,	,	,
cord-259237-aty0vrat	272	16	TSPO	TSPO	NNP
cord-259237-aty0vrat	272	17	was	be	VBD
cord-259237-aty0vrat	272	18	no	no	RB
cord-259237-aty0vrat	272	19	longer	longer	RB
cord-259237-aty0vrat	272	20	able	able	JJ
cord-259237-aty0vrat	272	21	to	to	TO
cord-259237-aty0vrat	272	22	suppress	suppress	VB
cord-259237-aty0vrat	272	23	the	the	DT
cord-259237-aty0vrat	272	24	Env	Env	NNP
cord-259237-aty0vrat	272	25	expression	expression	NN
cord-259237-aty0vrat	272	26	[	[	-LRB-
cord-259237-aty0vrat	272	27	145	145	CD
cord-259237-aty0vrat	272	28	]	]	-RRB-
cord-259237-aty0vrat	272	29	.	.	.
cord-259237-aty0vrat	273	1	These	these	DT
cord-259237-aty0vrat	273	2	results	result	NNS
cord-259237-aty0vrat	273	3	demonstrated	demonstrate	VBD
cord-259237-aty0vrat	273	4	that	that	IN
cord-259237-aty0vrat	273	5	ERManI	ERManI	NNP
cord-259237-aty0vrat	273	6	should	should	MD
cord-259237-aty0vrat	273	7	be	be	VB
cord-259237-aty0vrat	273	8	responsible	responsible	JJ
cord-259237-aty0vrat	273	9	for	for	IN
cord-259237-aty0vrat	273	10	the	the	DT
cord-259237-aty0vrat	273	11	initiation	initiation	NN
cord-259237-aty0vrat	273	12	of	of	IN
cord-259237-aty0vrat	273	13	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	273	14	Env	Env	NNP
cord-259237-aty0vrat	273	15	degradation	degradation	NN
cord-259237-aty0vrat	273	16	via	via	IN
cord-259237-aty0vrat	273	17	ERAD	ERAD	NNP
cord-259237-aty0vrat	273	18	.	.	.
cord-259237-aty0vrat	274	1	Human	Human	NNP
cord-259237-aty0vrat	274	2	ERManI	ERManI	NNP
cord-259237-aty0vrat	274	3	is	be	VBZ
cord-259237-aty0vrat	274	4	a	a	DT
cord-259237-aty0vrat	274	5	699-amino	699-amino	CD
cord-259237-aty0vrat	274	6	-	-	HYPH
cord-259237-aty0vrat	274	7	acid	acid	NN
cord-259237-aty0vrat	274	8	,	,	,
cord-259237-aty0vrat	274	9	79.5-kDa	79.5-kda	CD
cord-259237-aty0vrat	274	10	,	,	,
cord-259237-aty0vrat	274	11	type	type	NN
cord-259237-aty0vrat	274	12	II	II	NNP
cord-259237-aty0vrat	274	13	membrane	membrane	NN
cord-259237-aty0vrat	274	14	protein	protein	NN
cord-259237-aty0vrat	274	15	,	,	,
cord-259237-aty0vrat	274	16	which	which	WDT
cord-259237-aty0vrat	274	17	is	be	VBZ
cord-259237-aty0vrat	274	18	divided	divide	VBN
cord-259237-aty0vrat	274	19	into	into	IN
cord-259237-aty0vrat	274	20	an	an	DT
cord-259237-aty0vrat	274	21	N	n	CD
cord-259237-aty0vrat	274	22	-	-	HYPH
cord-259237-aty0vrat	274	23	terminal	terminal	JJ
cord-259237-aty0vrat	274	24	cytoplasmic	cytoplasmic	JJ
cord-259237-aty0vrat	274	25	domain	domain	NN
cord-259237-aty0vrat	274	26	(	(	-LRB-
cord-259237-aty0vrat	274	27	CD	CD	NNP
cord-259237-aty0vrat	274	28	)	)	-RRB-
cord-259237-aty0vrat	274	29	,	,	,
cord-259237-aty0vrat	274	30	transmembrane	transmembrane	NNP
cord-259237-aty0vrat	274	31	(	(	-LRB-
cord-259237-aty0vrat	274	32	TM	TM	NNP
cord-259237-aty0vrat	274	33	)	)	-RRB-
cord-259237-aty0vrat	274	34	helix	helix	NNP
cord-259237-aty0vrat	274	35	,	,	,
cord-259237-aty0vrat	274	36	lumenal	lumenal	NNP
cord-259237-aty0vrat	274	37	'	'	``
cord-259237-aty0vrat	274	38	stem	stem	NN
cord-259237-aty0vrat	274	39	'	'	''
cord-259237-aty0vrat	274	40	region	region	NN
cord-259237-aty0vrat	274	41	,	,	,
cord-259237-aty0vrat	274	42	and	and	CC
cord-259237-aty0vrat	274	43	a	a	DT
cord-259237-aty0vrat	274	44	catalytic	catalytic	JJ
cord-259237-aty0vrat	274	45	domain	domain	NN
cord-259237-aty0vrat	274	46	[	[	-LRB-
cord-259237-aty0vrat	274	47	146	146	CD
cord-259237-aty0vrat	274	48	,	,	,
cord-259237-aty0vrat	274	49	147	147	CD
cord-259237-aty0vrat	274	50	]	]	-RRB-
cord-259237-aty0vrat	274	51	.	.	.
cord-259237-aty0vrat	275	1	Using	use	VBG
cord-259237-aty0vrat	275	2	an	an	DT
cord-259237-aty0vrat	275	3	immunoprecipitation	immunoprecipitation	NN
cord-259237-aty0vrat	275	4	assay	assay	NN
cord-259237-aty0vrat	275	5	,	,	,
cord-259237-aty0vrat	275	6	we	-PRON-	PRP
cord-259237-aty0vrat	275	7	found	find	VBD
cord-259237-aty0vrat	275	8	that	that	IN
cord-259237-aty0vrat	275	9	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	275	10	Env	Env	NNP
cord-259237-aty0vrat	275	11	interacts	interact	VBZ
cord-259237-aty0vrat	275	12	with	with	IN
cord-259237-aty0vrat	275	13	the	the	DT
cord-259237-aty0vrat	275	14	catalytic	catalytic	JJ
cord-259237-aty0vrat	275	15	domain	domain	NN
cord-259237-aty0vrat	275	16	of	of	IN
cord-259237-aty0vrat	275	17	ERManI	ERManI	NNP
cord-259237-aty0vrat	275	18	[	[	-LRB-
cord-259237-aty0vrat	275	19	145	145	CD
cord-259237-aty0vrat	275	20	]	]	-RRB-
cord-259237-aty0vrat	275	21	.	.	.
cord-259237-aty0vrat	276	1	The	the	DT
cord-259237-aty0vrat	276	2	structure	structure	NN
cord-259237-aty0vrat	276	3	of	of	IN
cord-259237-aty0vrat	276	4	this	this	DT
cord-259237-aty0vrat	276	5	catalytic	catalytic	JJ
cord-259237-aty0vrat	276	6	domain	domain	NN
cord-259237-aty0vrat	276	7	shows	show	VBZ
cord-259237-aty0vrat	276	8	an	an	DT
cord-259237-aty0vrat	276	9	(	(	-LRB-
cord-259237-aty0vrat	276	10	αα	αα	NN
cord-259237-aty0vrat	276	11	)	)	-RRB-
cord-259237-aty0vrat	276	12	7	7	CD
cord-259237-aty0vrat	276	13	-barrel	-barrel	HYPH
cord-259237-aty0vrat	276	14	composed	compose	VBN
cord-259237-aty0vrat	276	15	of	of	IN
cord-259237-aty0vrat	276	16	14	14	CD
cord-259237-aty0vrat	276	17	consecutive	consecutive	JJ
cord-259237-aty0vrat	276	18	helices	helix	NNS
cord-259237-aty0vrat	276	19	[	[	-LRB-
cord-259237-aty0vrat	276	20	148	148	CD
cord-259237-aty0vrat	276	21	]	]	-RRB-
cord-259237-aty0vrat	276	22	.	.	.
cord-259237-aty0vrat	277	1	In	in	IN
cord-259237-aty0vrat	277	2	the	the	DT
cord-259237-aty0vrat	277	3	catalytic	catalytic	JJ
cord-259237-aty0vrat	277	4	domain	domain	NN
cord-259237-aty0vrat	277	5	,	,	,
cord-259237-aty0vrat	277	6	there	there	EX
cord-259237-aty0vrat	277	7	are	be	VBP
cord-259237-aty0vrat	277	8	seven	seven	CD
cord-259237-aty0vrat	277	9	residues	residue	NNS
cord-259237-aty0vrat	277	10	that	that	WDT
cord-259237-aty0vrat	277	11	are	be	VBP
cord-259237-aty0vrat	277	12	critical	critical	JJ
cord-259237-aty0vrat	277	13	for	for	IN
cord-259237-aty0vrat	277	14	ERManI	ERManI	NNP
cord-259237-aty0vrat	277	15	function	function	NN
cord-259237-aty0vrat	277	16	.	.	.
cord-259237-aty0vrat	278	1	C527	C527	NNP
cord-259237-aty0vrat	278	2	and	and	CC
cord-259237-aty0vrat	278	3	C556	C556	``
cord-259237-aty0vrat	278	4	form	form	VBP
cord-259237-aty0vrat	278	5	a	a	DT
cord-259237-aty0vrat	278	6	highly	highly	RB
cord-259237-aty0vrat	278	7	conserved	conserved	JJ
cord-259237-aty0vrat	278	8	disulfide	disulfide	JJ
cord-259237-aty0vrat	278	9	bond	bond	NN
cord-259237-aty0vrat	278	10	and	and	CC
cord-259237-aty0vrat	278	11	were	be	VBD
cord-259237-aty0vrat	278	12	reportedly	reportedly	RB
cord-259237-aty0vrat	278	13	critical	critical	JJ
cord-259237-aty0vrat	278	14	for	for	IN
cord-259237-aty0vrat	278	15	protein	protein	NN
cord-259237-aty0vrat	278	16	folding	fold	VBG
cord-259237-aty0vrat	278	17	[	[	-LRB-
cord-259237-aty0vrat	278	18	149	149	CD
cord-259237-aty0vrat	278	19	]	]	-RRB-
cord-259237-aty0vrat	278	20	,	,	,
cord-259237-aty0vrat	278	21	whereas	whereas	IN
cord-259237-aty0vrat	278	22	E330	E330	NNP
cord-259237-aty0vrat	278	23	,	,	,
cord-259237-aty0vrat	278	24	D463	D463	NNS
cord-259237-aty0vrat	278	25	,	,	,
cord-259237-aty0vrat	278	26	and	and	CC
cord-259237-aty0vrat	278	27	E599	E599	NNP
cord-259237-aty0vrat	278	28	were	be	VBD
cord-259237-aty0vrat	278	29	proposed	propose	VBN
cord-259237-aty0vrat	278	30	as	as	IN
cord-259237-aty0vrat	278	31	catalytic	catalytic	JJ
cord-259237-aty0vrat	278	32	residues	residue	NNS
cord-259237-aty0vrat	278	33	[	[	-LRB-
cord-259237-aty0vrat	278	34	148	148	CD
cord-259237-aty0vrat	278	35	]	]	-RRB-
cord-259237-aty0vrat	278	36	.	.	.
cord-259237-aty0vrat	279	1	R334C	R334C	NNS
cord-259237-aty0vrat	279	2	and	and	CC
cord-259237-aty0vrat	279	3	E397	E397	``
cord-259237-aty0vrat	279	4	K	k	NN
cord-259237-aty0vrat	279	5	mutations	mutation	NNS
cord-259237-aty0vrat	279	6	are	be	VBP
cord-259237-aty0vrat	279	7	found	find	VBN
cord-259237-aty0vrat	279	8	in	in	IN
cord-259237-aty0vrat	279	9	nonsyndromic	nonsyndromic	NNP
cord-259237-aty0vrat	279	10	autosomal	autosomal	JJ
cord-259237-aty0vrat	279	11	-	-	HYPH
cord-259237-aty0vrat	279	12	recessive	recessive	JJ
cord-259237-aty0vrat	279	13	intellectual	intellectual	JJ
cord-259237-aty0vrat	279	14	disability	disability	NN
cord-259237-aty0vrat	279	15	(	(	-LRB-
cord-259237-aty0vrat	279	16	NS	NS	NNP
cord-259237-aty0vrat	279	17	-	-	HYPH
cord-259237-aty0vrat	279	18	ARID	ARID	NNP
cord-259237-aty0vrat	279	19	)	)	-RRB-
cord-259237-aty0vrat	279	20	disease	disease	NN
cord-259237-aty0vrat	279	21	[	[	-LRB-
cord-259237-aty0vrat	279	22	150	150	CD
cord-259237-aty0vrat	279	23	]	]	-RRB-
cord-259237-aty0vrat	279	24	,	,	,
cord-259237-aty0vrat	279	25	and	and	CC
cord-259237-aty0vrat	279	26	the	the	DT
cord-259237-aty0vrat	279	27	R334C	R334C	NNP
cord-259237-aty0vrat	279	28	mutation	mutation	NN
cord-259237-aty0vrat	279	29	is	be	VBZ
cord-259237-aty0vrat	279	30	also	also	RB
cord-259237-aty0vrat	279	31	found	find	VBN
cord-259237-aty0vrat	279	32	in	in	IN
cord-259237-aty0vrat	279	33	the	the	DT
cord-259237-aty0vrat	279	34	congenital	congenital	JJ
cord-259237-aty0vrat	279	35	disorders	disorder	NNS
cord-259237-aty0vrat	279	36	of	of	IN
cord-259237-aty0vrat	279	37	glycosylation	glycosylation	NN
cord-259237-aty0vrat	279	38	[	[	-LRB-
cord-259237-aty0vrat	279	39	151	151	CD
cord-259237-aty0vrat	279	40	]	]	-RRB-
cord-259237-aty0vrat	279	41	.	.	.
cord-259237-aty0vrat	280	1	All	all	PDT
cord-259237-aty0vrat	280	2	these	these	DT
cord-259237-aty0vrat	280	3	residues	residue	NNS
cord-259237-aty0vrat	280	4	are	be	VBP
cord-259237-aty0vrat	280	5	required	require	VBN
cord-259237-aty0vrat	280	6	for	for	IN
cord-259237-aty0vrat	280	7	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	280	8	Env	Env	NNP
cord-259237-aty0vrat	280	9	degradation	degradation	NN
cord-259237-aty0vrat	280	10	,	,	,
cord-259237-aty0vrat	280	11	suggesting	suggest	VBG
cord-259237-aty0vrat	280	12	that	that	IN
cord-259237-aty0vrat	280	13	the	the	DT
cord-259237-aty0vrat	280	14	mannosidase	mannosidase	NN
cord-259237-aty0vrat	280	15	activity	activity	NN
cord-259237-aty0vrat	280	16	is	be	VBZ
cord-259237-aty0vrat	280	17	important	important	JJ
cord-259237-aty0vrat	280	18	for	for	IN
cord-259237-aty0vrat	280	19	the	the	DT
cord-259237-aty0vrat	280	20	ERManI	ERManI	NNP
cord-259237-aty0vrat	280	21	activity	activity	NN
cord-259237-aty0vrat	280	22	.	.	.
cord-259237-aty0vrat	281	1	ERManI	ERManI	NNP
cord-259237-aty0vrat	281	2	also	also	RB
cord-259237-aty0vrat	281	3	targets	target	VBZ
cord-259237-aty0vrat	281	4	the	the	DT
cord-259237-aty0vrat	281	5	terminally	terminally	RB
cord-259237-aty0vrat	281	6	misfolded	misfolde	VBN
cord-259237-aty0vrat	281	7	human	human	JJ
cord-259237-aty0vrat	281	8	alpha1-antitrypsin	alpha1-antitrypsin	NNP
cord-259237-aty0vrat	281	9	variant	variant	NN
cord-259237-aty0vrat	281	10	null	null	NN
cord-259237-aty0vrat	281	11	(	(	-LRB-
cord-259237-aty0vrat	281	12	Hong	Hong	NNP
cord-259237-aty0vrat	281	13	Kong	Kong	NNP
cord-259237-aty0vrat	281	14	)	)	-RRB-
cord-259237-aty0vrat	282	1	(	(	-LRB-
cord-259237-aty0vrat	282	2	NHK	NHK	NNP
cord-259237-aty0vrat	282	3	)	)	-RRB-
cord-259237-aty0vrat	282	4	for	for	IN
cord-259237-aty0vrat	282	5	degradation	degradation	NN
cord-259237-aty0vrat	282	6	via	via	IN
cord-259237-aty0vrat	282	7	ERAD	ERAD	NNP
cord-259237-aty0vrat	282	8	,	,	,
cord-259237-aty0vrat	282	9	but	but	CC
cord-259237-aty0vrat	282	10	neither	neither	CC
cord-259237-aty0vrat	282	11	its	-PRON-	PRP$
cord-259237-aty0vrat	282	12	catalytic	catalytic	JJ
cord-259237-aty0vrat	282	13	activity	activity	NN
cord-259237-aty0vrat	282	14	nor	nor	CC
cord-259237-aty0vrat	282	15	its	-PRON-	PRP$
cord-259237-aty0vrat	282	16	catalytic	catalytic	JJ
cord-259237-aty0vrat	282	17	domain	domain	NN
cord-259237-aty0vrat	282	18	is	be	VBZ
cord-259237-aty0vrat	282	19	required	require	VBN
cord-259237-aty0vrat	282	20	for	for	IN
cord-259237-aty0vrat	282	21	this	this	DT
cord-259237-aty0vrat	282	22	degradation	degradation	NN
cord-259237-aty0vrat	282	23	,	,	,
cord-259237-aty0vrat	282	24	suggesting	suggest	VBG
cord-259237-aty0vrat	282	25	that	that	IN
cord-259237-aty0vrat	282	26	different	different	JJ
cord-259237-aty0vrat	282	27	mechanisms	mechanism	NNS
cord-259237-aty0vrat	282	28	are	be	VBP
cord-259237-aty0vrat	282	29	involved	involve	VBN
cord-259237-aty0vrat	282	30	in	in	IN
cord-259237-aty0vrat	282	31	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	282	32	Env	Env	NNP
cord-259237-aty0vrat	282	33	and	and	CC
cord-259237-aty0vrat	282	34	NHK	NHK	NNP
cord-259237-aty0vrat	282	35	degradation	degradation	NN
cord-259237-aty0vrat	282	36	[	[	-LRB-
cord-259237-aty0vrat	282	37	152	152	CD
cord-259237-aty0vrat	282	38	]	]	-RRB-
cord-259237-aty0vrat	282	39	.	.	.
cord-259237-aty0vrat	283	1	We	-PRON-	PRP
cord-259237-aty0vrat	283	2	have	have	VBP
cord-259237-aty0vrat	283	3	also	also	RB
cord-259237-aty0vrat	283	4	found	find	VBN
cord-259237-aty0vrat	283	5	that	that	IN
cord-259237-aty0vrat	283	6	the	the	DT
cord-259237-aty0vrat	283	7	viral	viral	JJ
cord-259237-aty0vrat	283	8	protein	protein	NN
cord-259237-aty0vrat	283	9	R	r	NN
cord-259237-aty0vrat	283	10	(	(	-LRB-
cord-259237-aty0vrat	283	11	Vpr	Vpr	NNP
cord-259237-aty0vrat	283	12	)	)	-RRB-
cord-259237-aty0vrat	283	13	of	of	IN
cord-259237-aty0vrat	283	14	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	283	15	enhances	enhance	VBZ
cord-259237-aty0vrat	283	16	viral	viral	JJ
cord-259237-aty0vrat	283	17	replication	replication	NN
cord-259237-aty0vrat	283	18	in	in	IN
cord-259237-aty0vrat	283	19	monocyte	monocyte	NNP
cord-259237-aty0vrat	283	20	-	-	HYPH
cord-259237-aty0vrat	283	21	derived	derive	VBN
cord-259237-aty0vrat	283	22	macrophages	macrophage	NNS
cord-259237-aty0vrat	283	23	(	(	-LRB-
cord-259237-aty0vrat	283	24	MDMs	MDMs	NNP
cord-259237-aty0vrat	283	25	)	)	-RRB-
cord-259237-aty0vrat	283	26	and	and	CC
cord-259237-aty0vrat	283	27	dendritic	dendritic	JJ
cord-259237-aty0vrat	283	28	cells	cell	NNS
cord-259237-aty0vrat	283	29	(	(	-LRB-
cord-259237-aty0vrat	283	30	MDDCs	mddc	NNS
cord-259237-aty0vrat	283	31	)	)	-RRB-
cord-259237-aty0vrat	283	32	by	by	IN
cord-259237-aty0vrat	283	33	rescuing	rescue	VBG
cord-259237-aty0vrat	283	34	Env	Env	NNP
cord-259237-aty0vrat	283	35	from	from	IN
cord-259237-aty0vrat	283	36	ERAD	ERAD	NNP
cord-259237-aty0vrat	283	37	degradation	degradation	NN
cord-259237-aty0vrat	283	38	through	through	IN
cord-259237-aty0vrat	283	39	the	the	DT
cord-259237-aty0vrat	283	40	ERAD	ERAD	NNP
cord-259237-aty0vrat	283	41	(	(	-LRB-
cord-259237-aty0vrat	283	42	II	II	NNP
cord-259237-aty0vrat	283	43	)	)	-RRB-
cord-259237-aty0vrat	283	44	autophagy	autophagy	NN
cord-259237-aty0vrat	283	45	pathway	pathway	NN
cord-259237-aty0vrat	283	46	.	.	.
cord-259237-aty0vrat	284	1	Compounds	compound	NNS
cord-259237-aty0vrat	284	2	known	know	VBN
cord-259237-aty0vrat	284	3	to	to	TO
cord-259237-aty0vrat	284	4	facilitate	facilitate	VB
cord-259237-aty0vrat	284	5	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	284	6	folding	folding	NN
cord-259237-aty0vrat	284	7	(	(	-LRB-
cord-259237-aty0vrat	284	8	PK11195	pk11195	NN
cord-259237-aty0vrat	284	9	and	and	CC
cord-259237-aty0vrat	284	10	As	as	IN
cord-259237-aty0vrat	284	11	2	2	CD
cord-259237-aty0vrat	284	12	O	o	NN
cord-259237-aty0vrat	284	13	3	3	CD
cord-259237-aty0vrat	284	14	)	)	-RRB-
cord-259237-aty0vrat	284	15	and	and	CC
cord-259237-aty0vrat	284	16	inhibit	inhibit	VB
cord-259237-aty0vrat	284	17	ER	ER	NNP
cord-259237-aty0vrat	284	18	α	α	NN
cord-259237-aty0vrat	284	19	-	-	HYPH
cord-259237-aty0vrat	284	20	mannosidases	mannosidase	NNS
cord-259237-aty0vrat	284	21	crucial	crucial	JJ
cord-259237-aty0vrat	284	22	for	for	IN
cord-259237-aty0vrat	284	23	ERAD	ERAD	NNP
cord-259237-aty0vrat	284	24	(	(	-LRB-
cord-259237-aty0vrat	284	25	Kifunensine	Kifunensine	NNP
cord-259237-aty0vrat	284	26	)	)	-RRB-
cord-259237-aty0vrat	284	27	,	,	,
cord-259237-aty0vrat	284	28	and	and	CC
cord-259237-aty0vrat	284	29	those	those	DT
cord-259237-aty0vrat	284	30	that	that	DT
cord-259237-aty0vrat	284	31	block	block	NN
cord-259237-aty0vrat	284	32	lysosomal	lysosomal	JJ
cord-259237-aty0vrat	284	33	proteases	protease	NNS
cord-259237-aty0vrat	284	34	(	(	-LRB-
cord-259237-aty0vrat	284	35	Bafilomycin	Bafilomycin	NNP
cord-259237-aty0vrat	284	36	)	)	-RRB-
cord-259237-aty0vrat	284	37	rescued	rescue	VBN
cord-259237-aty0vrat	284	38	envelope	envelope	NN
cord-259237-aty0vrat	284	39	expression	expression	NN
cord-259237-aty0vrat	284	40	and	and	CC
cord-259237-aty0vrat	284	41	infectivity	infectivity	NN
cord-259237-aty0vrat	284	42	in	in	IN
cord-259237-aty0vrat	284	43	a	a	DT
cord-259237-aty0vrat	284	44	∆Vpr	∆vpr	NN
cord-259237-aty0vrat	284	45	background	background	NN
cord-259237-aty0vrat	284	46	to	to	IN
cord-259237-aty0vrat	284	47	that	that	DT
cord-259237-aty0vrat	284	48	of	of	IN
cord-259237-aty0vrat	284	49	wild	wild	JJ
cord-259237-aty0vrat	284	50	-	-	HYPH
cord-259237-aty0vrat	284	51	type	type	NN
cord-259237-aty0vrat	284	52	virus	virus	NN
cord-259237-aty0vrat	284	53	[	[	-LRB-
cord-259237-aty0vrat	284	54	153	153	CD
cord-259237-aty0vrat	284	55	]	]	-RRB-
cord-259237-aty0vrat	284	56	.	.	.
cord-259237-aty0vrat	285	1	As	as	IN
cord-259237-aty0vrat	285	2	aforementioned	aforementioned	JJ
cord-259237-aty0vrat	285	3	,	,	,
cord-259237-aty0vrat	285	4	unlike	unlike	IN
cord-259237-aty0vrat	285	5	ERManI	ERManI	NNP
cord-259237-aty0vrat	285	6	,	,	,
cord-259237-aty0vrat	285	7	whose	whose	WP$
cord-259237-aty0vrat	285	8	expression	expression	NN
cord-259237-aty0vrat	285	9	is	be	VBZ
cord-259237-aty0vrat	285	10	not	not	RB
cord-259237-aty0vrat	285	11	responsive	responsive	JJ
cord-259237-aty0vrat	285	12	to	to	IN
cord-259237-aty0vrat	285	13	UPR	UPR	NNP
cord-259237-aty0vrat	285	14	,	,	,
cord-259237-aty0vrat	285	15	the	the	DT
cord-259237-aty0vrat	285	16	expression	expression	NN
cord-259237-aty0vrat	285	17	of	of	IN
cord-259237-aty0vrat	285	18	the	the	DT
cord-259237-aty0vrat	285	19	EDEMs	edem	NNS
cord-259237-aty0vrat	285	20	is	be	VBZ
cord-259237-aty0vrat	285	21	induced	induce	VBN
cord-259237-aty0vrat	285	22	upon	upon	IN
cord-259237-aty0vrat	285	23	UPR	UPR	NNP
cord-259237-aty0vrat	285	24	via	via	IN
cord-259237-aty0vrat	285	25	the	the	DT
cord-259237-aty0vrat	285	26	IRE1	IRE1	NNP
cord-259237-aty0vrat	285	27	/	/	SYM
cord-259237-aty0vrat	285	28	XBP	XBP	NNP
cord-259237-aty0vrat	285	29	activation	activation	NN
cord-259237-aty0vrat	285	30	pathway	pathway	NN
cord-259237-aty0vrat	285	31	,	,	,
cord-259237-aty0vrat	285	32	which	which	WDT
cord-259237-aty0vrat	285	33	boosts	boost	VBZ
cord-259237-aty0vrat	285	34	ERAD	ERAD	NNP
cord-259237-aty0vrat	285	35	and	and	CC
cord-259237-aty0vrat	285	36	alleviates	alleviate	VBZ
cord-259237-aty0vrat	285	37	ER	ER	NNP
cord-259237-aty0vrat	285	38	stress	stress	NN
cord-259237-aty0vrat	285	39	.	.	.
cord-259237-aty0vrat	286	1	Although	although	IN
cord-259237-aty0vrat	286	2	ectopic	ectopic	JJ
cord-259237-aty0vrat	286	3	expression	expression	NN
cord-259237-aty0vrat	286	4	of	of	IN
cord-259237-aty0vrat	286	5	EDEMs	edem	NNS
cord-259237-aty0vrat	286	6	did	do	VBD
cord-259237-aty0vrat	286	7	not	not	RB
cord-259237-aty0vrat	286	8	inhibit	inhibit	VB
cord-259237-aty0vrat	286	9	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	286	10	Env	Env	NNP
cord-259237-aty0vrat	286	11	expression	expression	NN
cord-259237-aty0vrat	286	12	[	[	-LRB-
cord-259237-aty0vrat	286	13	145	145	CD
cord-259237-aty0vrat	286	14	]	]	-RRB-
cord-259237-aty0vrat	286	15	,	,	,
cord-259237-aty0vrat	286	16	these	these	DT
cord-259237-aty0vrat	286	17	proteins	protein	NNS
cord-259237-aty0vrat	286	18	inhibit	inhibit	VBP
cord-259237-aty0vrat	286	19	the	the	DT
cord-259237-aty0vrat	286	20	expression	expression	NN
cord-259237-aty0vrat	286	21	of	of	IN
cord-259237-aty0vrat	286	22	some	some	DT
cord-259237-aty0vrat	286	23	other	other	JJ
cord-259237-aty0vrat	286	24	envelope	envelope	NN
cord-259237-aty0vrat	286	25	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	286	26	.	.	.
cord-259237-aty0vrat	287	1	HBV	HBV	NNP
cord-259237-aty0vrat	287	2	expresses	express	VBZ
cord-259237-aty0vrat	287	3	three	three	CD
cord-259237-aty0vrat	287	4	surface	surface	NN
cord-259237-aty0vrat	287	5	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	287	6	,	,	,
cord-259237-aty0vrat	287	7	the	the	DT
cord-259237-aty0vrat	287	8	large	large	JJ
cord-259237-aty0vrat	287	9	(	(	-LRB-
cord-259237-aty0vrat	287	10	L	L	NNP
cord-259237-aty0vrat	287	11	)	)	-RRB-
cord-259237-aty0vrat	287	12	,	,	,
cord-259237-aty0vrat	287	13	middle	middle	JJ
cord-259237-aty0vrat	287	14	(	(	-LRB-
cord-259237-aty0vrat	287	15	M	M	NNP
cord-259237-aty0vrat	287	16	)	)	-RRB-
cord-259237-aty0vrat	287	17	,	,	,
cord-259237-aty0vrat	287	18	and	and	CC
cord-259237-aty0vrat	287	19	small	small	JJ
cord-259237-aty0vrat	287	20	(	(	-LRB-
cord-259237-aty0vrat	287	21	S	S	NNP
cord-259237-aty0vrat	287	22	)	)	-RRB-
cord-259237-aty0vrat	287	23	,	,	,
cord-259237-aty0vrat	287	24	which	which	WDT
cord-259237-aty0vrat	287	25	are	be	VBP
cord-259237-aty0vrat	287	26	translated	translate	VBN
cord-259237-aty0vrat	287	27	from	from	IN
cord-259237-aty0vrat	287	28	different	different	JJ
cord-259237-aty0vrat	287	29	initiation	initiation	NN
cord-259237-aty0vrat	287	30	codons	codon	NNS
cord-259237-aty0vrat	287	31	within	within	IN
cord-259237-aty0vrat	287	32	the	the	DT
cord-259237-aty0vrat	287	33	same	same	JJ
cord-259237-aty0vrat	287	34	open	open	JJ
cord-259237-aty0vrat	287	35	reading	reading	NN
cord-259237-aty0vrat	287	36	frame	frame	NN
cord-259237-aty0vrat	287	37	(	(	-LRB-
cord-259237-aty0vrat	287	38	ORF	ORF	NNP
cord-259237-aty0vrat	287	39	)	)	-RRB-
cord-259237-aty0vrat	287	40	and	and	CC
cord-259237-aty0vrat	287	41	share	share	VB
cord-259237-aty0vrat	287	42	the	the	DT
cord-259237-aty0vrat	287	43	tetra	tetra	NN
cord-259237-aty0vrat	287	44	-	-	HYPH
cord-259237-aty0vrat	287	45	spanning	span	VBG
cord-259237-aty0vrat	287	46	transmembrane	transmembrane	NN
cord-259237-aty0vrat	287	47	domains	domain	NNS
cord-259237-aty0vrat	287	48	in	in	IN
cord-259237-aty0vrat	287	49	the	the	DT
cord-259237-aty0vrat	287	50	S	S	NNP
cord-259237-aty0vrat	287	51	protein	protein	NN
cord-259237-aty0vrat	287	52	.	.	.
cord-259237-aty0vrat	288	1	The	the	DT
cord-259237-aty0vrat	288	2	N	N	NNP
cord-259237-aty0vrat	288	3	-	-	HYPH
cord-259237-aty0vrat	288	4	terminus	terminus	NN
cord-259237-aty0vrat	288	5	of	of	IN
cord-259237-aty0vrat	288	6	the	the	DT
cord-259237-aty0vrat	288	7	M	M	NNP
cord-259237-aty0vrat	288	8	and	and	CC
cord-259237-aty0vrat	288	9	L	L	NNP
cord-259237-aty0vrat	288	10	protein	protein	NN
cord-259237-aty0vrat	288	11	contain	contain	VBP
cord-259237-aty0vrat	288	12	additional	additional	JJ
cord-259237-aty0vrat	288	13	preS2	preS2	.
cord-259237-aty0vrat	289	1	and	and	CC
cord-259237-aty0vrat	289	2	preS1-preS2	preS1-preS2	NNP
cord-259237-aty0vrat	289	3	domains	domain	NNS
cord-259237-aty0vrat	289	4	,	,	,
cord-259237-aty0vrat	289	5	respectively	respectively	RB
cord-259237-aty0vrat	289	6	.	.	.
cord-259237-aty0vrat	290	1	The	the	DT
cord-259237-aty0vrat	290	2	common	common	JJ
cord-259237-aty0vrat	290	3	S	S	NNP
cord-259237-aty0vrat	290	4	domain	domain	NN
cord-259237-aty0vrat	290	5	has	have	VBZ
cord-259237-aty0vrat	290	6	an	an	DT
cord-259237-aty0vrat	290	7	N	n	CD
cord-259237-aty0vrat	290	8	-	-	HYPH
cord-259237-aty0vrat	290	9	glycosylation	glycosylation	NN
cord-259237-aty0vrat	290	10	site	site	NN
cord-259237-aty0vrat	290	11	,	,	,
cord-259237-aty0vrat	290	12	and	and	CC
cord-259237-aty0vrat	290	13	the	the	DT
cord-259237-aty0vrat	290	14	M	M	NNP
cord-259237-aty0vrat	290	15	preS2	preS2	NNP
cord-259237-aty0vrat	290	16	domain	domain	NN
cord-259237-aty0vrat	290	17	has	have	VBZ
cord-259237-aty0vrat	290	18	another	another	DT
cord-259237-aty0vrat	290	19	site	site	NN
cord-259237-aty0vrat	290	20	.	.	.
cord-259237-aty0vrat	291	1	Overexpression	overexpression	NN
cord-259237-aty0vrat	291	2	of	of	IN
cord-259237-aty0vrat	291	3	the	the	DT
cord-259237-aty0vrat	291	4	surface	surface	NN
cord-259237-aty0vrat	291	5	proteins	protein	NNS
cord-259237-aty0vrat	291	6	is	be	VBZ
cord-259237-aty0vrat	291	7	sufficient	sufficient	JJ
cord-259237-aty0vrat	291	8	to	to	TO
cord-259237-aty0vrat	291	9	activate	activate	VB
cord-259237-aty0vrat	291	10	the	the	DT
cord-259237-aty0vrat	291	11	IRE1	IRE1	NNP
cord-259237-aty0vrat	291	12	/	/	SYM
cord-259237-aty0vrat	291	13	XBP1	XBP1	NNP
cord-259237-aty0vrat	291	14	pathway	pathway	NN
cord-259237-aty0vrat	291	15	and	and	CC
cord-259237-aty0vrat	291	16	elevate	elevate	VBP
cord-259237-aty0vrat	291	17	EDEM1	edem1	NN
cord-259237-aty0vrat	291	18	,	,	,
cord-259237-aty0vrat	291	19	EDEM2	EDEM2	NNS
cord-259237-aty0vrat	291	20	,	,	,
cord-259237-aty0vrat	291	21	and	and	CC
cord-259237-aty0vrat	291	22	EDEM3	edem3	JJ
cord-259237-aty0vrat	291	23	expression	expression	NN
cord-259237-aty0vrat	291	24	.	.	.
cord-259237-aty0vrat	292	1	Importantly	importantly	RB
cord-259237-aty0vrat	292	2	,	,	,
cord-259237-aty0vrat	292	3	EDEM1	edem1	NN
cord-259237-aty0vrat	292	4	overexpression	overexpression	NN
cord-259237-aty0vrat	292	5	destabilizes	destabilize	VBZ
cord-259237-aty0vrat	292	6	S	S	NNP
cord-259237-aty0vrat	292	7	,	,	,
cord-259237-aty0vrat	292	8	M	M	NNP
cord-259237-aty0vrat	292	9	,	,	,
cord-259237-aty0vrat	292	10	and	and	CC
cord-259237-aty0vrat	292	11	L	L	NNP
cord-259237-aty0vrat	292	12	,	,	,
cord-259237-aty0vrat	292	13	and	and	CC
cord-259237-aty0vrat	292	14	EDEM1	EDEM1	VBZ
cord-259237-aty0vrat	292	15	silencing	silencing	NN
cord-259237-aty0vrat	292	16	stabilizes	stabilize	VBZ
cord-259237-aty0vrat	292	17	their	-PRON-	PRP$
cord-259237-aty0vrat	292	18	expression	expression	NN
cord-259237-aty0vrat	292	19	[	[	-LRB-
cord-259237-aty0vrat	292	20	154	154	CD
cord-259237-aty0vrat	292	21	]	]	-RRB-
cord-259237-aty0vrat	292	22	.	.	.
cord-259237-aty0vrat	293	1	In	in	IN
cord-259237-aty0vrat	293	2	addition	addition	NN
cord-259237-aty0vrat	293	3	,	,	,
cord-259237-aty0vrat	293	4	the	the	DT
cord-259237-aty0vrat	293	5	autophagy	autophagy	NN
cord-259237-aty0vrat	293	6	/	/	SYM
cord-259237-aty0vrat	293	7	lysosomal	lysosomal	JJ
cord-259237-aty0vrat	293	8	pathway	pathway	NN
cord-259237-aty0vrat	293	9	,	,	,
cord-259237-aty0vrat	293	10	but	but	CC
cord-259237-aty0vrat	293	11	not	not	RB
cord-259237-aty0vrat	293	12	the	the	DT
cord-259237-aty0vrat	293	13	proteasomal	proteasomal	JJ
cord-259237-aty0vrat	293	14	pathway	pathway	NN
cord-259237-aty0vrat	293	15	,	,	,
cord-259237-aty0vrat	293	16	is	be	VBZ
cord-259237-aty0vrat	293	17	involved	involve	VBN
cord-259237-aty0vrat	293	18	in	in	IN
cord-259237-aty0vrat	293	19	the	the	DT
cord-259237-aty0vrat	293	20	degradation	degradation	NN
cord-259237-aty0vrat	293	21	of	of	IN
cord-259237-aty0vrat	293	22	HBV	HBV	NNP
cord-259237-aty0vrat	293	23	surface	surface	NN
cord-259237-aty0vrat	293	24	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	293	25	,	,	,
cord-259237-aty0vrat	293	26	further	further	RB
cord-259237-aty0vrat	293	27	complicating	complicate	VBG
cord-259237-aty0vrat	293	28	our	-PRON-	PRP$
cord-259237-aty0vrat	293	29	understanding	understanding	NN
cord-259237-aty0vrat	293	30	of	of	IN
cord-259237-aty0vrat	293	31	the	the	DT
cord-259237-aty0vrat	293	32	viral	viral	JJ
cord-259237-aty0vrat	293	33	protein	protein	NN
cord-259237-aty0vrat	293	34	degradation	degradation	NN
cord-259237-aty0vrat	293	35	process	process	NN
cord-259237-aty0vrat	293	36	via	via	IN
cord-259237-aty0vrat	293	37	ERAD	ERAD	NNP
cord-259237-aty0vrat	293	38	[	[	-LRB-
cord-259237-aty0vrat	293	39	154	154	CD
cord-259237-aty0vrat	293	40	]	]	-RRB-
cord-259237-aty0vrat	293	41	.	.	.
cord-259237-aty0vrat	294	1	HCV	HCV	NNP
cord-259237-aty0vrat	294	2	has	have	VBZ
cord-259237-aty0vrat	294	3	two	two	CD
cord-259237-aty0vrat	294	4	N	n	CD
cord-259237-aty0vrat	294	5	-	-	HYPH
cord-259237-aty0vrat	294	6	glycosylated	glycosylated	JJ
cord-259237-aty0vrat	294	7	envelope	envelope	NN
cord-259237-aty0vrat	294	8	proteins	protein	NNS
cord-259237-aty0vrat	294	9	E1	E1	NNP
cord-259237-aty0vrat	294	10	and	and	CC
cord-259237-aty0vrat	294	11	E2	E2	NNP
cord-259237-aty0vrat	294	12	on	on	IN
cord-259237-aty0vrat	294	13	the	the	DT
cord-259237-aty0vrat	294	14	surface	surface	NN
cord-259237-aty0vrat	294	15	of	of	IN
cord-259237-aty0vrat	294	16	virions	virion	NNS
cord-259237-aty0vrat	294	17	,	,	,
cord-259237-aty0vrat	294	18	which	which	WDT
cord-259237-aty0vrat	294	19	are	be	VBP
cord-259237-aty0vrat	294	20	type	type	NN
cord-259237-aty0vrat	294	21	I	-PRON-	PRP
cord-259237-aty0vrat	294	22	transmembrane	transmembrane	NN
cord-259237-aty0vrat	294	23	proteins	protein	NNS
cord-259237-aty0vrat	294	24	expressed	express	VBN
cord-259237-aty0vrat	294	25	from	from	IN
cord-259237-aty0vrat	294	26	a	a	DT
cord-259237-aty0vrat	294	27	common	common	JJ
cord-259237-aty0vrat	294	28	viral	viral	JJ
cord-259237-aty0vrat	294	29	polyprotein	polyprotein	JJ
cord-259237-aty0vrat	294	30	precursor	precursor	NN
cord-259237-aty0vrat	294	31	.	.	.
cord-259237-aty0vrat	295	1	HCV	HCV	NNP
cord-259237-aty0vrat	295	2	infection	infection	NN
cord-259237-aty0vrat	295	3	strongly	strongly	RB
cord-259237-aty0vrat	295	4	induces	induce	VBZ
cord-259237-aty0vrat	295	5	the	the	DT
cord-259237-aty0vrat	295	6	activation	activation	NN
cord-259237-aty0vrat	295	7	of	of	IN
cord-259237-aty0vrat	295	8	the	the	DT
cord-259237-aty0vrat	295	9	IRE1	IRE1	NNP
cord-259237-aty0vrat	295	10	stress	stress	NN
cord-259237-aty0vrat	295	11	sensor	sensor	NN
cord-259237-aty0vrat	295	12	,	,	,
cord-259237-aty0vrat	295	13	resulting	result	VBG
cord-259237-aty0vrat	295	14	in	in	IN
cord-259237-aty0vrat	295	15	elevation	elevation	NN
cord-259237-aty0vrat	295	16	of	of	IN
cord-259237-aty0vrat	295	17	EDEM1	edem1	NN
cord-259237-aty0vrat	295	18	,	,	,
cord-259237-aty0vrat	295	19	EDEM2	EDEM2	NNP
cord-259237-aty0vrat	295	20	,	,	,
cord-259237-aty0vrat	295	21	and	and	CC
cord-259237-aty0vrat	295	22	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	295	23	,	,	,
cord-259237-aty0vrat	295	24	but	but	CC
cord-259237-aty0vrat	295	25	not	not	RB
cord-259237-aty0vrat	295	26	the	the	DT
cord-259237-aty0vrat	295	27	ERManI	ERManI	NNP
cord-259237-aty0vrat	295	28	expression	expression	NN
cord-259237-aty0vrat	295	29	.	.	.
cord-259237-aty0vrat	296	1	Both	both	DT
cord-259237-aty0vrat	296	2	EDEM1	EDEM1	NNS
cord-259237-aty0vrat	296	3	and	and	CC
cord-259237-aty0vrat	296	4	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	296	5	,	,	,
cord-259237-aty0vrat	296	6	but	but	CC
cord-259237-aty0vrat	296	7	not	not	RB
cord-259237-aty0vrat	296	8	EDEM2	EDEM2	NNP
cord-259237-aty0vrat	296	9	,	,	,
cord-259237-aty0vrat	296	10	interact	interact	VB
cord-259237-aty0vrat	296	11	with	with	IN
cord-259237-aty0vrat	296	12	E2	E2	NNP
cord-259237-aty0vrat	296	13	,	,	,
cord-259237-aty0vrat	296	14	and	and	CC
cord-259237-aty0vrat	296	15	overexpression	overexpression	NN
cord-259237-aty0vrat	296	16	of	of	IN
cord-259237-aty0vrat	296	17	these	these	DT
cord-259237-aty0vrat	296	18	two	two	CD
cord-259237-aty0vrat	296	19	proteins	protein	NNS
cord-259237-aty0vrat	296	20	induces	induce	VBZ
cord-259237-aty0vrat	296	21	E2	E2	NNP
cord-259237-aty0vrat	296	22	polyubiquitylation	polyubiquitylation	NN
cord-259237-aty0vrat	296	23	and	and	CC
cord-259237-aty0vrat	296	24	degradation	degradation	NN
cord-259237-aty0vrat	296	25	.	.	.
cord-259237-aty0vrat	297	1	Conversely	conversely	RB
cord-259237-aty0vrat	297	2	,	,	,
cord-259237-aty0vrat	297	3	knockdown	knockdown	NN
cord-259237-aty0vrat	297	4	of	of	IN
cord-259237-aty0vrat	297	5	EDEM1	edem1	NN
cord-259237-aty0vrat	297	6	expression	expression	NN
cord-259237-aty0vrat	297	7	or	or	CC
cord-259237-aty0vrat	297	8	treatment	treatment	NN
cord-259237-aty0vrat	297	9	with	with	IN
cord-259237-aty0vrat	297	10	kifunesine	kifunesine	NNP
cord-259237-aty0vrat	297	11	increases	increase	VBZ
cord-259237-aty0vrat	297	12	E2	E2	NNP
cord-259237-aty0vrat	297	13	expression	expression	NN
cord-259237-aty0vrat	297	14	,	,	,
cord-259237-aty0vrat	297	15	and	and	CC
cord-259237-aty0vrat	297	16	also	also	RB
cord-259237-aty0vrat	297	17	reduces	reduce	VBZ
cord-259237-aty0vrat	297	18	the	the	DT
cord-259237-aty0vrat	297	19	interaction	interaction	NN
cord-259237-aty0vrat	297	20	of	of	IN
cord-259237-aty0vrat	297	21	EDEM1	edem1	NN
cord-259237-aty0vrat	298	1	and	and	CC
cord-259237-aty0vrat	298	2	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	298	3	with	with	IN
cord-259237-aty0vrat	298	4	SEL1L	sel1l	JJ
cord-259237-aty0vrat	298	5	[	[	-LRB-
cord-259237-aty0vrat	298	6	155	155	CD
cord-259237-aty0vrat	298	7	]	]	-RRB-
cord-259237-aty0vrat	298	8	.	.	.
cord-259237-aty0vrat	299	1	Taken	take	VBN
cord-259237-aty0vrat	299	2	together	together	RB
cord-259237-aty0vrat	299	3	,	,	,
cord-259237-aty0vrat	299	4	these	these	DT
cord-259237-aty0vrat	299	5	results	result	NNS
cord-259237-aty0vrat	299	6	strongly	strongly	RB
cord-259237-aty0vrat	299	7	suggest	suggest	VBP
cord-259237-aty0vrat	299	8	that	that	IN
cord-259237-aty0vrat	299	9	EDEM	EDEM	NNP
cord-259237-aty0vrat	299	10	proteins	protein	NNS
cord-259237-aty0vrat	299	11	are	be	VBP
cord-259237-aty0vrat	299	12	able	able	JJ
cord-259237-aty0vrat	299	13	to	to	TO
cord-259237-aty0vrat	299	14	extract	extract	VB
cord-259237-aty0vrat	299	15	viral	viral	JJ
cord-259237-aty0vrat	299	16	polypeptides	polypeptide	NNS
cord-259237-aty0vrat	299	17	from	from	IN
cord-259237-aty0vrat	299	18	the	the	DT
cord-259237-aty0vrat	299	19	ER	ER	NNP
cord-259237-aty0vrat	299	20	quality	quality	NN
cord-259237-aty0vrat	299	21	control	control	NN
cord-259237-aty0vrat	299	22	cycle	cycle	NN
cord-259237-aty0vrat	299	23	,	,	,
cord-259237-aty0vrat	299	24	and	and	CC
cord-259237-aty0vrat	299	25	degrade	degrade	VB
cord-259237-aty0vrat	299	26	them	-PRON-	PRP
cord-259237-aty0vrat	299	27	via	via	IN
cord-259237-aty0vrat	299	28	ERAD	ERAD	NNP
cord-259237-aty0vrat	299	29	.	.	.
cord-259237-aty0vrat	300	1	However	however	RB
cord-259237-aty0vrat	300	2	,	,	,
cord-259237-aty0vrat	300	3	since	since	IN
cord-259237-aty0vrat	300	4	none	none	NN
cord-259237-aty0vrat	300	5	of	of	IN
cord-259237-aty0vrat	300	6	these	these	DT
cord-259237-aty0vrat	300	7	proteins	protein	NNS
cord-259237-aty0vrat	300	8	can	can	MD
cord-259237-aty0vrat	300	9	target	target	VB
cord-259237-aty0vrat	300	10	the	the	DT
cord-259237-aty0vrat	300	11	JEV	JEV	NNP
cord-259237-aty0vrat	300	12	E	e	NN
cord-259237-aty0vrat	300	13	protein	protein	NN
cord-259237-aty0vrat	300	14	to	to	IN
cord-259237-aty0vrat	300	15	ERAD	ERAD	NNP
cord-259237-aty0vrat	300	16	for	for	IN
cord-259237-aty0vrat	300	17	degradation	degradation	NN
cord-259237-aty0vrat	300	18	,	,	,
cord-259237-aty0vrat	300	19	not	not	RB
cord-259237-aty0vrat	300	20	every	every	DT
cord-259237-aty0vrat	300	21	viral	viral	JJ
cord-259237-aty0vrat	300	22	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	300	23	is	be	VBZ
cord-259237-aty0vrat	300	24	recognizable	recognizable	JJ
cord-259237-aty0vrat	300	25	by	by	IN
cord-259237-aty0vrat	300	26	these	these	DT
cord-259237-aty0vrat	300	27	proteins	protein	NNS
cord-259237-aty0vrat	300	28	[	[	-LRB-
cord-259237-aty0vrat	300	29	155	155	CD
cord-259237-aty0vrat	300	30	]	]	-RRB-
cord-259237-aty0vrat	300	31	.	.	.
cord-259237-aty0vrat	301	1	In	in	IN
cord-259237-aty0vrat	301	2	vivo	vivo	NN
cord-259237-aty0vrat	301	3	experiments	experiment	NNS
cord-259237-aty0vrat	301	4	on	on	IN
cord-259237-aty0vrat	301	5	patients	patient	NNS
cord-259237-aty0vrat	301	6	with	with	IN
cord-259237-aty0vrat	301	7	chronic	chronic	JJ
cord-259237-aty0vrat	301	8	liver	liver	NN
cord-259237-aty0vrat	301	9	injury	injury	NN
cord-259237-aty0vrat	301	10	were	be	VBD
cord-259237-aty0vrat	301	11	unable	unable	JJ
cord-259237-aty0vrat	301	12	to	to	TO
cord-259237-aty0vrat	301	13	identify	identify	VB
cord-259237-aty0vrat	301	14	up	up	RP
cord-259237-aty0vrat	301	15	-	-	HYPH
cord-259237-aty0vrat	301	16	regulation	regulation	NN
cord-259237-aty0vrat	301	17	of	of	IN
cord-259237-aty0vrat	301	18	UPR	UPR	NNP
cord-259237-aty0vrat	301	19	and	and	CC
cord-259237-aty0vrat	301	20	ERAD	ERAD	NNP
cord-259237-aty0vrat	301	21	elements	element	NNS
cord-259237-aty0vrat	301	22	in	in	IN
cord-259237-aty0vrat	301	23	diseased	disease	VBN
cord-259237-aty0vrat	301	24	versus	versus	IN
cord-259237-aty0vrat	301	25	control	control	NN
cord-259237-aty0vrat	301	26	patients	patient	NNS
cord-259237-aty0vrat	301	27	[	[	-LRB-
cord-259237-aty0vrat	301	28	156	156	CD
cord-259237-aty0vrat	301	29	]	]	-RRB-
cord-259237-aty0vrat	301	30	.	.	.
cord-259237-aty0vrat	302	1	ERAD	ERAD	NNP
cord-259237-aty0vrat	302	2	has	have	VBZ
cord-259237-aty0vrat	302	3	also	also	RB
cord-259237-aty0vrat	302	4	been	be	VBN
cord-259237-aty0vrat	302	5	implicated	implicate	VBN
cord-259237-aty0vrat	302	6	in	in	IN
cord-259237-aty0vrat	302	7	the	the	DT
cord-259237-aty0vrat	302	8	degradation	degradation	NN
cord-259237-aty0vrat	302	9	of	of	IN
cord-259237-aty0vrat	302	10	HCMV	HCMV	NNP
cord-259237-aty0vrat	302	11	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	302	12	,	,	,
cord-259237-aty0vrat	302	13	gH	gh	NN
cord-259237-aty0vrat	302	14	and	and	CC
cord-259237-aty0vrat	302	15	gL	gL	NNP
cord-259237-aty0vrat	302	16	,	,	,
cord-259237-aty0vrat	302	17	via	via	IN
cord-259237-aty0vrat	302	18	the	the	DT
cord-259237-aty0vrat	302	19	26S	26S	NNP
cord-259237-aty0vrat	302	20	proteasome	proteasome	NN
cord-259237-aty0vrat	302	21	.	.	.
cord-259237-aty0vrat	303	1	HCMV	HCMV	NNP
cord-259237-aty0vrat	303	2	produces	produce	VBZ
cord-259237-aty0vrat	303	3	at	at	IN
cord-259237-aty0vrat	303	4	least	least	RBS
cord-259237-aty0vrat	303	5	65	65	CD
cord-259237-aty0vrat	303	6	unique	unique	JJ
cord-259237-aty0vrat	303	7	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	303	8	,	,	,
cord-259237-aty0vrat	303	9	with	with	IN
cord-259237-aty0vrat	303	10	four	four	CD
cord-259237-aty0vrat	303	11	homologues	homologue	NNS
cord-259237-aty0vrat	303	12	to	to	IN
cord-259237-aty0vrat	303	13	the	the	DT
cord-259237-aty0vrat	303	14	HSV	HSV	NNP
cord-259237-aty0vrat	303	15	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	303	16	,	,	,
cord-259237-aty0vrat	303	17	gH	gH	NNP
cord-259237-aty0vrat	303	18	,	,	,
cord-259237-aty0vrat	303	19	gB	gB	NNP
cord-259237-aty0vrat	303	20	,	,	,
cord-259237-aty0vrat	303	21	gL	gL	NNP
cord-259237-aty0vrat	303	22	,	,	,
cord-259237-aty0vrat	303	23	and	and	CC
cord-259237-aty0vrat	303	24	gM	gM	NNP
cord-259237-aty0vrat	303	25	[	[	-LRB-
cord-259237-aty0vrat	303	26	157	157	CD
cord-259237-aty0vrat	303	27	]	]	-RRB-
cord-259237-aty0vrat	303	28	.	.	.
cord-259237-aty0vrat	304	1	The	the	DT
cord-259237-aty0vrat	304	2	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	304	3	,	,	,
cord-259237-aty0vrat	304	4	gH	gh	NN
cord-259237-aty0vrat	304	5	and	and	CC
cord-259237-aty0vrat	304	6	gL	gL	NNP
cord-259237-aty0vrat	304	7	,	,	,
cord-259237-aty0vrat	304	8	are	be	VBP
cord-259237-aty0vrat	304	9	constituents	constituent	NNS
cord-259237-aty0vrat	304	10	of	of	IN
cord-259237-aty0vrat	304	11	the	the	DT
cord-259237-aty0vrat	304	12	gcII	gcII	NNP
cord-259237-aty0vrat	304	13	type	type	NN
cord-259237-aty0vrat	304	14	complexes	complex	NNS
cord-259237-aty0vrat	304	15	found	find	VBN
cord-259237-aty0vrat	304	16	on	on	IN
cord-259237-aty0vrat	304	17	the	the	DT
cord-259237-aty0vrat	304	18	surface	surface	NN
cord-259237-aty0vrat	304	19	of	of	IN
cord-259237-aty0vrat	304	20	HCMV	HCMV	NNP
cord-259237-aty0vrat	304	21	virions	virion	NNS
cord-259237-aty0vrat	304	22	.	.	.
cord-259237-aty0vrat	305	1	The	the	DT
cord-259237-aty0vrat	305	2	gcII	gcII	NNP
cord-259237-aty0vrat	305	3	trimeric	trimeric	NN
cord-259237-aty0vrat	305	4	complex	complex	NN
cord-259237-aty0vrat	305	5	between	between	IN
cord-259237-aty0vrat	305	6	gH	gh	NN
cord-259237-aty0vrat	305	7	,	,	,
cord-259237-aty0vrat	305	8	gL	gL	NNP
cord-259237-aty0vrat	305	9	,	,	,
cord-259237-aty0vrat	305	10	and	and	CC
cord-259237-aty0vrat	305	11	gO	go	VB
cord-259237-aty0vrat	305	12	can	can	MD
cord-259237-aty0vrat	305	13	initiate	initiate	VB
cord-259237-aty0vrat	305	14	pH	pH	NNP
cord-259237-aty0vrat	305	15	independent	independent	JJ
cord-259237-aty0vrat	305	16	fusion	fusion	NN
cord-259237-aty0vrat	305	17	[	[	-LRB-
cord-259237-aty0vrat	305	18	158	158	CD
cord-259237-aty0vrat	305	19	]	]	-RRB-
cord-259237-aty0vrat	305	20	.	.	.
cord-259237-aty0vrat	306	1	In	in	IN
cord-259237-aty0vrat	306	2	addition	addition	NN
cord-259237-aty0vrat	306	3	,	,	,
cord-259237-aty0vrat	306	4	a	a	DT
cord-259237-aty0vrat	306	5	pentameric	pentameric	NN
cord-259237-aty0vrat	306	6	complex	complex	NN
cord-259237-aty0vrat	306	7	between	between	IN
cord-259237-aty0vrat	306	8	gH	gh	NN
cord-259237-aty0vrat	306	9	,	,	,
cord-259237-aty0vrat	306	10	gL	gL	NNP
cord-259237-aty0vrat	306	11	,	,	,
cord-259237-aty0vrat	306	12	and	and	CC
cord-259237-aty0vrat	306	13	the	the	DT
cord-259237-aty0vrat	306	14	gene	gene	NN
cord-259237-aty0vrat	306	15	products	product	NNS
cord-259237-aty0vrat	306	16	U128	U128	NNP
cord-259237-aty0vrat	306	17	,	,	,
cord-259237-aty0vrat	306	18	U130	u130	UH
cord-259237-aty0vrat	306	19	,	,	,
cord-259237-aty0vrat	306	20	and	and	CC
cord-259237-aty0vrat	306	21	U131	U131	NNP
cord-259237-aty0vrat	306	22	is	be	VBZ
cord-259237-aty0vrat	306	23	able	able	JJ
cord-259237-aty0vrat	306	24	to	to	TO
cord-259237-aty0vrat	306	25	mediate	mediate	VB
cord-259237-aty0vrat	306	26	entry	entry	NN
cord-259237-aty0vrat	306	27	into	into	IN
cord-259237-aty0vrat	306	28	different	different	JJ
cord-259237-aty0vrat	306	29	cell	cell	NN
cord-259237-aty0vrat	306	30	types	type	NNS
cord-259237-aty0vrat	306	31	via	via	IN
cord-259237-aty0vrat	306	32	pH	ph	JJ
cord-259237-aty0vrat	306	33	-	-	HYPH
cord-259237-aty0vrat	306	34	dependent	dependent	JJ
cord-259237-aty0vrat	306	35	receptor	receptor	NN
cord-259237-aty0vrat	306	36	-	-	HYPH
cord-259237-aty0vrat	306	37	mediated	mediate	VBN
cord-259237-aty0vrat	306	38	endocytosis	endocytosis	NN
cord-259237-aty0vrat	306	39	;	;	:
cord-259237-aty0vrat	306	40	a	a	DT
cord-259237-aty0vrat	306	41	process	process	NN
cord-259237-aty0vrat	306	42	that	that	WDT
cord-259237-aty0vrat	306	43	requires	require	VBZ
cord-259237-aty0vrat	306	44	the	the	DT
cord-259237-aty0vrat	306	45	trimeric	trimeric	NNP
cord-259237-aty0vrat	306	46	gH	gh	NN
cord-259237-aty0vrat	306	47	/	/	SYM
cord-259237-aty0vrat	306	48	gL	gL	NNP
cord-259237-aty0vrat	306	49	/	/	SYM
cord-259237-aty0vrat	306	50	gO	go	VB
cord-259237-aty0vrat	306	51	complex	complex	JJ
cord-259237-aty0vrat	306	52	[	[	-LRB-
cord-259237-aty0vrat	306	53	159	159	CD
cord-259237-aty0vrat	306	54	]	]	-RRB-
cord-259237-aty0vrat	306	55	.	.	.
cord-259237-aty0vrat	307	1	Although	although	IN
cord-259237-aty0vrat	307	2	previous	previous	JJ
cord-259237-aty0vrat	307	3	studies	study	NNS
cord-259237-aty0vrat	307	4	have	have	VBP
cord-259237-aty0vrat	307	5	shown	show	VBN
cord-259237-aty0vrat	307	6	that	that	IN
cord-259237-aty0vrat	307	7	the	the	DT
cord-259237-aty0vrat	307	8	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	307	9	gL	gl	NN
cord-259237-aty0vrat	307	10	stabilizes	stabilize	VBZ
cord-259237-aty0vrat	307	11	the	the	DT
cord-259237-aty0vrat	307	12	expression	expression	NN
cord-259237-aty0vrat	307	13	of	of	IN
cord-259237-aty0vrat	307	14	gH	gh	NN
cord-259237-aty0vrat	307	15	and	and	CC
cord-259237-aty0vrat	307	16	potentiates	potentiate	VBZ
cord-259237-aty0vrat	307	17	its	-PRON-	PRP$
cord-259237-aty0vrat	307	18	surface	surface	NN
cord-259237-aty0vrat	307	19	localization	localization	NN
cord-259237-aty0vrat	307	20	[	[	-LRB-
cord-259237-aty0vrat	307	21	160	160	CD
cord-259237-aty0vrat	307	22	]	]	-RRB-
cord-259237-aty0vrat	307	23	,	,	,
cord-259237-aty0vrat	307	24	recent	recent	JJ
cord-259237-aty0vrat	307	25	work	work	NN
cord-259237-aty0vrat	307	26	revealed	reveal	VBD
cord-259237-aty0vrat	307	27	that	that	IN
cord-259237-aty0vrat	307	28	gH	gH	NNP
cord-259237-aty0vrat	307	29	is	be	VBZ
cord-259237-aty0vrat	307	30	degraded	degrade	VBN
cord-259237-aty0vrat	307	31	via	via	IN
cord-259237-aty0vrat	307	32	ERAD	ERAD	NNP
cord-259237-aty0vrat	307	33	in	in	IN
cord-259237-aty0vrat	307	34	the	the	DT
cord-259237-aty0vrat	307	35	absence	absence	NN
cord-259237-aty0vrat	307	36	of	of	IN
cord-259237-aty0vrat	307	37	gL	gl	NN
cord-259237-aty0vrat	307	38	[	[	-LRB-
cord-259237-aty0vrat	307	39	161	161	CD
cord-259237-aty0vrat	307	40	]	]	-RRB-
cord-259237-aty0vrat	307	41	.	.	.
cord-259237-aty0vrat	308	1	Replacement	replacement	NN
cord-259237-aty0vrat	308	2	of	of	IN
cord-259237-aty0vrat	308	3	the	the	DT
cord-259237-aty0vrat	308	4	cytoplasmic	cytoplasmic	JJ
cord-259237-aty0vrat	308	5	tail	tail	NN
cord-259237-aty0vrat	308	6	of	of	IN
cord-259237-aty0vrat	308	7	gH	gh	NN
cord-259237-aty0vrat	308	8	with	with	IN
cord-259237-aty0vrat	308	9	that	that	DT
cord-259237-aty0vrat	308	10	of	of	IN
cord-259237-aty0vrat	308	11	the	the	DT
cord-259237-aty0vrat	308	12	human	human	JJ
cord-259237-aty0vrat	308	13	CD4	CD4	NNP
cord-259237-aty0vrat	308	14	protein	protein	NN
cord-259237-aty0vrat	308	15	subverted	subvert	VBD
cord-259237-aty0vrat	308	16	gH	gh	NN
cord-259237-aty0vrat	308	17	degradation	degradation	NN
cord-259237-aty0vrat	308	18	via	via	IN
cord-259237-aty0vrat	308	19	ERAD	ERAD	NNP
cord-259237-aty0vrat	308	20	,	,	,
cord-259237-aty0vrat	308	21	potentiating	potentiate	VBG
cord-259237-aty0vrat	308	22	surface	surface	NN
cord-259237-aty0vrat	308	23	expression	expression	NN
cord-259237-aty0vrat	308	24	.	.	.
cord-259237-aty0vrat	309	1	Current	current	JJ
cord-259237-aty0vrat	309	2	studies	study	NNS
cord-259237-aty0vrat	309	3	describe	describe	VBP
cord-259237-aty0vrat	309	4	two	two	CD
cord-259237-aty0vrat	309	5	paradigms	paradigm	NNS
cord-259237-aty0vrat	309	6	for	for	IN
cord-259237-aty0vrat	309	7	ERAD	ERAD	NNP
cord-259237-aty0vrat	309	8	to	to	TO
cord-259237-aty0vrat	309	9	target	target	VB
cord-259237-aty0vrat	309	10	viral	viral	JJ
cord-259237-aty0vrat	309	11	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	309	12	for	for	IN
cord-259237-aty0vrat	309	13	degradation	degradation	NN
cord-259237-aty0vrat	309	14	:	:	:
cord-259237-aty0vrat	309	15	ERManI	ERManI	NNP
cord-259237-aty0vrat	309	16	-	-	HYPH
cord-259237-aty0vrat	309	17	mediated	mediate	VBN
cord-259237-aty0vrat	309	18	,	,	,
cord-259237-aty0vrat	309	19	which	which	WDT
cord-259237-aty0vrat	309	20	targets	target	VBZ
cord-259237-aty0vrat	309	21	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	309	22	Env	Env	NNP
cord-259237-aty0vrat	309	23	,	,	,
cord-259237-aty0vrat	309	24	and	and	CC
cord-259237-aty0vrat	309	25	EDEM	EDEM	NNP
cord-259237-aty0vrat	309	26	-	-	HYPH
cord-259237-aty0vrat	309	27	mediated	mediate	VBN
cord-259237-aty0vrat	309	28	,	,	,
cord-259237-aty0vrat	309	29	which	which	WDT
cord-259237-aty0vrat	309	30	can	can	MD
cord-259237-aty0vrat	309	31	target	target	VB
cord-259237-aty0vrat	309	32	HCV	HCV	NNP
cord-259237-aty0vrat	309	33	and	and	CC
cord-259237-aty0vrat	309	34	HBV	HBV	NNP
cord-259237-aty0vrat	309	35	surface	surface	NN
cord-259237-aty0vrat	309	36	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	309	37	.	.	.
cord-259237-aty0vrat	310	1	GH47	gh47	NN
cord-259237-aty0vrat	310	2	family	family	NN
cord-259237-aty0vrat	310	3	members	member	NNS
cord-259237-aty0vrat	310	4	share	share	VBP
cord-259237-aty0vrat	310	5	a	a	DT
cord-259237-aty0vrat	310	6	common	common	JJ
cord-259237-aty0vrat	310	7	catalytic	catalytic	JJ
cord-259237-aty0vrat	310	8	mannosidase	mannosidase	NN
cord-259237-aty0vrat	310	9	homology	homology	NN
cord-259237-aty0vrat	310	10	domain	domain	NN
cord-259237-aty0vrat	311	1	of~440-residues	of~440-residue	NNS
cord-259237-aty0vrat	311	2	[	[	-LRB-
cord-259237-aty0vrat	311	3	52	52	CD
cord-259237-aty0vrat	311	4	]	]	-RRB-
cord-259237-aty0vrat	311	5	,	,	,
cord-259237-aty0vrat	311	6	and	and	CC
cord-259237-aty0vrat	311	7	the	the	DT
cord-259237-aty0vrat	311	8	three	three	CD
cord-259237-aty0vrat	311	9	catalytic	catalytic	JJ
cord-259237-aty0vrat	311	10	residues	residue	NNS
cord-259237-aty0vrat	311	11	E330	e330	NN
cord-259237-aty0vrat	311	12	,	,	,
cord-259237-aty0vrat	311	13	D463	D463	NNS
cord-259237-aty0vrat	311	14	,	,	,
cord-259237-aty0vrat	311	15	and	and	CC
cord-259237-aty0vrat	311	16	E599	E599	NNS
cord-259237-aty0vrat	311	17	found	find	VBD
cord-259237-aty0vrat	311	18	in	in	IN
cord-259237-aty0vrat	311	19	ERManI	ERManI	NNP
cord-259237-aty0vrat	311	20	are	be	VBP
cord-259237-aty0vrat	311	21	all	all	DT
cord-259237-aty0vrat	311	22	conserved	conserve	VBN
cord-259237-aty0vrat	311	23	in	in	IN
cord-259237-aty0vrat	311	24	these	these	DT
cord-259237-aty0vrat	311	25	proteins	protein	NNS
cord-259237-aty0vrat	311	26	[	[	-LRB-
cord-259237-aty0vrat	311	27	43	43	CD
cord-259237-aty0vrat	311	28	]	]	-RRB-
cord-259237-aty0vrat	311	29	.	.	.
cord-259237-aty0vrat	312	1	Nevertheless	nevertheless	RB
cord-259237-aty0vrat	312	2	,	,	,
cord-259237-aty0vrat	312	3	there	there	EX
cord-259237-aty0vrat	312	4	is	be	VBZ
cord-259237-aty0vrat	312	5	little	little	JJ
cord-259237-aty0vrat	312	6	protein	protein	NN
cord-259237-aty0vrat	312	7	sequence	sequence	NN
cord-259237-aty0vrat	312	8	homology	homology	NN
cord-259237-aty0vrat	312	9	beyond	beyond	IN
cord-259237-aty0vrat	312	10	this	this	DT
cord-259237-aty0vrat	312	11	domain	domain	NN
cord-259237-aty0vrat	312	12	among	among	IN
cord-259237-aty0vrat	312	13	these	these	DT
cord-259237-aty0vrat	312	14	proteins	protein	NNS
cord-259237-aty0vrat	312	15	.	.	.
cord-259237-aty0vrat	313	1	Unlike	unlike	IN
cord-259237-aty0vrat	313	2	ERManI	ERManI	NNP
cord-259237-aty0vrat	313	3	,	,	,
cord-259237-aty0vrat	313	4	all	all	DT
cord-259237-aty0vrat	313	5	three	three	CD
cord-259237-aty0vrat	313	6	EDEMs	edem	NNS
cord-259237-aty0vrat	313	7	are	be	VBP
cord-259237-aty0vrat	313	8	ER	ER	NNP
cord-259237-aty0vrat	313	9	-	-	HYPH
cord-259237-aty0vrat	313	10	lumenal	lumenal	JJ
cord-259237-aty0vrat	313	11	proteins	protein	NNS
cord-259237-aty0vrat	313	12	,	,	,
cord-259237-aty0vrat	313	13	although	although	IN
cord-259237-aty0vrat	313	14	the	the	DT
cord-259237-aty0vrat	313	15	signal	signal	NN
cord-259237-aty0vrat	313	16	sequence	sequence	NN
cord-259237-aty0vrat	313	17	of	of	IN
cord-259237-aty0vrat	313	18	EDEM1	edem1	NN
cord-259237-aty0vrat	313	19	is	be	VBZ
cord-259237-aty0vrat	313	20	resistant	resistant	JJ
cord-259237-aty0vrat	313	21	to	to	IN
cord-259237-aty0vrat	313	22	cleavage	cleavage	NN
cord-259237-aty0vrat	313	23	[	[	-LRB-
cord-259237-aty0vrat	313	24	162	162	CD
cord-259237-aty0vrat	313	25	]	]	-RRB-
cord-259237-aty0vrat	313	26	.	.	.
cord-259237-aty0vrat	314	1	EDEM3	EDEM3	NNP
cord-259237-aty0vrat	314	2	has	have	VBZ
cord-259237-aty0vrat	314	3	two	two	CD
cord-259237-aty0vrat	314	4	novel	novel	NN
cord-259237-aty0vrat	314	5	features	feature	NNS
cord-259237-aty0vrat	314	6	including	include	VBG
cord-259237-aty0vrat	314	7	an	an	DT
cord-259237-aty0vrat	314	8	additional	additional	JJ
cord-259237-aty0vrat	314	9	protease	protease	NN
cord-259237-aty0vrat	314	10	-	-	HYPH
cord-259237-aty0vrat	314	11	associated	associate	VBN
cord-259237-aty0vrat	314	12	domain	domain	NN
cord-259237-aty0vrat	314	13	of	of	IN
cord-259237-aty0vrat	314	14	unknown	unknown	JJ
cord-259237-aty0vrat	314	15	function	function	NN
cord-259237-aty0vrat	314	16	and	and	CC
cord-259237-aty0vrat	314	17	a	a	DT
cord-259237-aty0vrat	314	18	KDEL	KDEL	NNP
cord-259237-aty0vrat	314	19	signal	signal	NN
cord-259237-aty0vrat	314	20	for	for	IN
cord-259237-aty0vrat	314	21	ER	ER	NNP
cord-259237-aty0vrat	314	22	retention	retention	NN
cord-259237-aty0vrat	314	23	[	[	-LRB-
cord-259237-aty0vrat	314	24	45	45	CD
cord-259237-aty0vrat	314	25	]	]	-RRB-
cord-259237-aty0vrat	314	26	.	.	.
cord-259237-aty0vrat	315	1	Whether	whether	IN
cord-259237-aty0vrat	315	2	or	or	CC
cord-259237-aty0vrat	315	3	how	how	WRB
cord-259237-aty0vrat	315	4	the	the	DT
cord-259237-aty0vrat	315	5	coordination	coordination	NN
cord-259237-aty0vrat	315	6	between	between	IN
cord-259237-aty0vrat	315	7	the	the	DT
cord-259237-aty0vrat	315	8	EDEMs	edem	NNS
cord-259237-aty0vrat	315	9	and	and	CC
cord-259237-aty0vrat	315	10	ERManI	ERManI	NNP
cord-259237-aty0vrat	315	11	facilitates	facilitate	VBZ
cord-259237-aty0vrat	315	12	ERAD	ERAD	NNP
cord-259237-aty0vrat	315	13	is	be	VBZ
cord-259237-aty0vrat	315	14	still	still	RB
cord-259237-aty0vrat	315	15	a	a	DT
cord-259237-aty0vrat	315	16	convoluted	convoluted	JJ
cord-259237-aty0vrat	315	17	issue	issue	NN
cord-259237-aty0vrat	315	18	.	.	.
cord-259237-aty0vrat	316	1	Due	due	IN
cord-259237-aty0vrat	316	2	to	to	IN
cord-259237-aty0vrat	316	3	lysosomal	lysosomal	JJ
cord-259237-aty0vrat	316	4	degradation	degradation	NN
cord-259237-aty0vrat	316	5	mediated	mediate	VBN
cord-259237-aty0vrat	316	6	by	by	IN
cord-259237-aty0vrat	316	7	the	the	DT
cord-259237-aty0vrat	316	8	N	n	CD
cord-259237-aty0vrat	316	9	-	-	HYPH
cord-259237-aty0vrat	316	10	terminal	terminal	JJ
cord-259237-aty0vrat	316	11	cytoplasmic	cytoplasmic	JJ
cord-259237-aty0vrat	316	12	tail	tail	NN
cord-259237-aty0vrat	316	13	,	,	,
cord-259237-aty0vrat	316	14	ERManI	ERManI	NNP
cord-259237-aty0vrat	316	15	is	be	VBZ
cord-259237-aty0vrat	316	16	expressed	express	VBN
cord-259237-aty0vrat	316	17	at	at	IN
cord-259237-aty0vrat	316	18	very	very	RB
cord-259237-aty0vrat	316	19	low	low	JJ
cord-259237-aty0vrat	316	20	basal	basal	NN
cord-259237-aty0vrat	316	21	levels	level	NNS
cord-259237-aty0vrat	316	22	in	in	IN
cord-259237-aty0vrat	316	23	cells	cell	NNS
cord-259237-aty0vrat	316	24	,	,	,
cord-259237-aty0vrat	316	25	and	and	CC
cord-259237-aty0vrat	316	26	its	-PRON-	PRP$
cord-259237-aty0vrat	316	27	expression	expression	NN
cord-259237-aty0vrat	316	28	is	be	VBZ
cord-259237-aty0vrat	316	29	not	not	RB
cord-259237-aty0vrat	316	30	induced	induce	VBN
cord-259237-aty0vrat	316	31	by	by	IN
cord-259237-aty0vrat	316	32	UPR	UPR	NNP
cord-259237-aty0vrat	316	33	[	[	-LRB-
cord-259237-aty0vrat	316	34	86	86	CD
cord-259237-aty0vrat	316	35	]	]	-RRB-
cord-259237-aty0vrat	316	36	.	.	.
cord-259237-aty0vrat	317	1	Such	such	JJ
cord-259237-aty0vrat	317	2	proteolytically	proteolytically	RB
cord-259237-aty0vrat	317	3	driven	drive	VBN
cord-259237-aty0vrat	317	4	checkpoint	checkpoint	NN
cord-259237-aty0vrat	317	5	control	control	NN
cord-259237-aty0vrat	317	6	of	of	IN
cord-259237-aty0vrat	317	7	ERManI	ERManI	NNP
cord-259237-aty0vrat	317	8	expression	expression	NN
cord-259237-aty0vrat	317	9	may	may	MD
cord-259237-aty0vrat	317	10	contribute	contribute	VB
cord-259237-aty0vrat	317	11	to	to	TO
cord-259237-aty0vrat	317	12	establish	establish	VB
cord-259237-aty0vrat	317	13	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	317	14	quality	quality	NN
cord-259237-aty0vrat	317	15	control	control	NN
cord-259237-aty0vrat	317	16	at	at	IN
cord-259237-aty0vrat	317	17	a	a	DT
cord-259237-aty0vrat	317	18	baseline	baseline	JJ
cord-259237-aty0vrat	317	19	level	level	NN
cord-259237-aty0vrat	317	20	,	,	,
cord-259237-aty0vrat	317	21	which	which	WDT
cord-259237-aty0vrat	317	22	maintains	maintain	VBZ
cord-259237-aty0vrat	317	23	ER	ER	NNP
cord-259237-aty0vrat	317	24	homeostasis	homeostasis	NN
cord-259237-aty0vrat	317	25	without	without	IN
cord-259237-aty0vrat	317	26	activation	activation	NN
cord-259237-aty0vrat	317	27	of	of	IN
cord-259237-aty0vrat	317	28	IRE1	IRE1	NNP
cord-259237-aty0vrat	317	29	/	/	SYM
cord-259237-aty0vrat	317	30	XBP1	XBP1	NNP
cord-259237-aty0vrat	317	31	.	.	.
cord-259237-aty0vrat	318	1	However	however	RB
cord-259237-aty0vrat	318	2	,	,	,
cord-259237-aty0vrat	318	3	if	if	IN
cord-259237-aty0vrat	318	4	this	this	DT
cord-259237-aty0vrat	318	5	basic	basic	JJ
cord-259237-aty0vrat	318	6	mechanism	mechanism	NN
cord-259237-aty0vrat	318	7	fails	fail	VBZ
cord-259237-aty0vrat	318	8	to	to	TO
cord-259237-aty0vrat	318	9	restore	restore	VB
cord-259237-aty0vrat	318	10	ER	ER	NNP
cord-259237-aty0vrat	318	11	homeostasis	homeostasis	NN
cord-259237-aty0vrat	318	12	,	,	,
cord-259237-aty0vrat	318	13	IRE1	IRE1	NNP
cord-259237-aty0vrat	318	14	/	/	SYM
cord-259237-aty0vrat	318	15	XBP1	XBP1	NNP
cord-259237-aty0vrat	318	16	is	be	VBZ
cord-259237-aty0vrat	318	17	induced	induce	VBN
cord-259237-aty0vrat	318	18	to	to	TO
cord-259237-aty0vrat	318	19	elevate	elevate	VB
cord-259237-aty0vrat	318	20	expression	expression	NN
cord-259237-aty0vrat	318	21	of	of	IN
cord-259237-aty0vrat	318	22	the	the	DT
cord-259237-aty0vrat	318	23	EDEMs	edem	NNS
cord-259237-aty0vrat	318	24	,	,	,
cord-259237-aty0vrat	318	25	which	which	WDT
cord-259237-aty0vrat	318	26	will	will	MD
cord-259237-aty0vrat	318	27	increase	increase	VB
cord-259237-aty0vrat	318	28	ERAD	ERAD	NNP
cord-259237-aty0vrat	318	29	.	.	.
cord-259237-aty0vrat	319	1	Unlike	unlike	IN
cord-259237-aty0vrat	319	2	HCV	HCV	NNP
cord-259237-aty0vrat	319	3	and	and	CC
cord-259237-aty0vrat	319	4	HBV	HBV	NNP
cord-259237-aty0vrat	319	5	,	,	,
cord-259237-aty0vrat	319	6	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	319	7	induces	induce	VBZ
cord-259237-aty0vrat	319	8	UPR	UPR	NNP
cord-259237-aty0vrat	319	9	,	,	,
cord-259237-aty0vrat	319	10	but	but	CC
cord-259237-aty0vrat	319	11	barely	barely	RB
cord-259237-aty0vrat	319	12	activates	activate	VBZ
cord-259237-aty0vrat	319	13	the	the	DT
cord-259237-aty0vrat	319	14	IRE1	IRE1	NNP
cord-259237-aty0vrat	319	15	/	/	SYM
cord-259237-aty0vrat	319	16	XBP1	XBP1	NNP
cord-259237-aty0vrat	319	17	pathway	pathway	NN
cord-259237-aty0vrat	319	18	,	,	,
cord-259237-aty0vrat	319	19	which	which	WDT
cord-259237-aty0vrat	319	20	may	may	MD
cord-259237-aty0vrat	319	21	explain	explain	VB
cord-259237-aty0vrat	319	22	why	why	WRB
cord-259237-aty0vrat	319	23	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	319	24	Env	Env	NNP
cord-259237-aty0vrat	319	25	is	be	VBZ
cord-259237-aty0vrat	319	26	not	not	RB
cord-259237-aty0vrat	319	27	directly	directly	RB
cord-259237-aty0vrat	319	28	targeted	target	VBN
cord-259237-aty0vrat	319	29	by	by	IN
cord-259237-aty0vrat	319	30	EDEM	EDEM	NNP
cord-259237-aty0vrat	319	31	proteins	protein	NNS
cord-259237-aty0vrat	319	32	[	[	-LRB-
cord-259237-aty0vrat	319	33	93	93	CD
cord-259237-aty0vrat	319	34	]	]	-RRB-
cord-259237-aty0vrat	319	35	.	.	.
cord-259237-aty0vrat	320	1	Nevertheless	nevertheless	RB
cord-259237-aty0vrat	320	2	,	,	,
cord-259237-aty0vrat	320	3	these	these	DT
cord-259237-aty0vrat	320	4	two	two	CD
cord-259237-aty0vrat	320	5	different	different	JJ
cord-259237-aty0vrat	320	6	arms	arm	NNS
cord-259237-aty0vrat	320	7	of	of	IN
cord-259237-aty0vrat	320	8	ERAD	ERAD	NNP
cord-259237-aty0vrat	320	9	do	do	VBP
cord-259237-aty0vrat	320	10	not	not	RB
cord-259237-aty0vrat	320	11	exclude	exclude	VB
cord-259237-aty0vrat	320	12	the	the	DT
cord-259237-aty0vrat	320	13	role	role	NN
cord-259237-aty0vrat	320	14	of	of	IN
cord-259237-aty0vrat	320	15	the	the	DT
cord-259237-aty0vrat	320	16	EDEMs	edem	NNS
cord-259237-aty0vrat	320	17	in	in	IN
cord-259237-aty0vrat	320	18	ERManI	ERManI	NNP
cord-259237-aty0vrat	320	19	-	-	HYPH
cord-259237-aty0vrat	320	20	mediated	mediate	VBN
cord-259237-aty0vrat	320	21	degradation	degradation	NN
cord-259237-aty0vrat	320	22	.	.	.
cord-259237-aty0vrat	321	1	EDEMs	EDEMs	NNP
cord-259237-aty0vrat	321	2	may	may	MD
cord-259237-aty0vrat	321	3	accelerate	accelerate	VB
cord-259237-aty0vrat	321	4	the	the	DT
cord-259237-aty0vrat	321	5	release	release	NN
cord-259237-aty0vrat	321	6	of	of	IN
cord-259237-aty0vrat	321	7	terminally	terminally	RB
cord-259237-aty0vrat	321	8	misfolded	misfolde	VBN
cord-259237-aty0vrat	321	9	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	321	10	from	from	IN
cord-259237-aty0vrat	321	11	the	the	DT
cord-259237-aty0vrat	321	12	CNX	CNX	NNP
cord-259237-aty0vrat	321	13	/	/	SYM
cord-259237-aty0vrat	321	14	CRT	CRT	NNP
cord-259237-aty0vrat	321	15	cycle	cycle	NN
cord-259237-aty0vrat	321	16	,	,	,
cord-259237-aty0vrat	321	17	and	and	CC
cord-259237-aty0vrat	321	18	thereby	thereby	RB
cord-259237-aty0vrat	321	19	help	help	VB
cord-259237-aty0vrat	321	20	ERManI	ERManI	NNP
cord-259237-aty0vrat	321	21	to	to	TO
cord-259237-aty0vrat	321	22	conduct	conduct	VB
cord-259237-aty0vrat	321	23	more	more	RBR
cord-259237-aty0vrat	321	24	extensive	extensive	JJ
cord-259237-aty0vrat	321	25	demannosylation	demannosylation	NN
cord-259237-aty0vrat	321	26	[	[	-LRB-
cord-259237-aty0vrat	321	27	163	163	CD
cord-259237-aty0vrat	321	28	]	]	-RRB-
cord-259237-aty0vrat	321	29	;	;	:
cord-259237-aty0vrat	321	30	and	and	CC
cord-259237-aty0vrat	321	31	the	the	DT
cord-259237-aty0vrat	321	32	association	association	NN
cord-259237-aty0vrat	321	33	of	of	IN
cord-259237-aty0vrat	321	34	EDEM	EDEM	NNP
cord-259237-aty0vrat	321	35	with	with	IN
cord-259237-aty0vrat	321	36	SEL1L	sel1l	CD
cord-259237-aty0vrat	321	37	may	may	MD
cord-259237-aty0vrat	321	38	further	further	RB
cord-259237-aty0vrat	321	39	accelerate	accelerate	VB
cord-259237-aty0vrat	321	40	the	the	DT
cord-259237-aty0vrat	321	41	cytosolic	cytosolic	JJ
cord-259237-aty0vrat	321	42	delivery	delivery	NN
cord-259237-aty0vrat	321	43	of	of	IN
cord-259237-aty0vrat	321	44	misfolded	misfolde	VBN
cord-259237-aty0vrat	321	45	proteins	protein	NNS
cord-259237-aty0vrat	321	46	[	[	-LRB-
cord-259237-aty0vrat	321	47	164	164	CD
cord-259237-aty0vrat	321	48	]	]	-RRB-
cord-259237-aty0vrat	321	49	.	.	.
cord-259237-aty0vrat	322	1	Moreover	moreover	RB
cord-259237-aty0vrat	322	2	,	,	,
cord-259237-aty0vrat	322	3	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	322	4	may	may	MD
cord-259237-aty0vrat	322	5	form	form	VB
cord-259237-aty0vrat	322	6	a	a	DT
cord-259237-aty0vrat	322	7	complex	complex	NN
cord-259237-aty0vrat	322	8	with	with	IN
cord-259237-aty0vrat	322	9	ERManI	ERManI	NNP
cord-259237-aty0vrat	322	10	,	,	,
cord-259237-aty0vrat	322	11	which	which	WDT
cord-259237-aty0vrat	322	12	stabilizes	stabilize	VBZ
cord-259237-aty0vrat	322	13	ERManI	ERManI	NNP
cord-259237-aty0vrat	322	14	by	by	IN
cord-259237-aty0vrat	322	15	the	the	DT
cord-259237-aty0vrat	322	16	suppression	suppression	NN
cord-259237-aty0vrat	322	17	of	of	IN
cord-259237-aty0vrat	322	18	its	-PRON-	PRP$
cord-259237-aty0vrat	322	19	proteolytic	proteolytic	JJ
cord-259237-aty0vrat	322	20	degradation	degradation	NN
cord-259237-aty0vrat	322	21	[	[	-LRB-
cord-259237-aty0vrat	322	22	86	86	CD
cord-259237-aty0vrat	322	23	]	]	-RRB-
cord-259237-aty0vrat	322	24	.	.	.
cord-259237-aty0vrat	323	1	Discrepancies	discrepancy	NNS
cord-259237-aty0vrat	323	2	concerning	concern	VBG
cord-259237-aty0vrat	323	3	the	the	DT
cord-259237-aty0vrat	323	4	localization	localization	NN
cord-259237-aty0vrat	323	5	of	of	IN
cord-259237-aty0vrat	323	6	ERManI	ERManI	NNP
cord-259237-aty0vrat	323	7	with	with	IN
cord-259237-aty0vrat	323	8	various	various	JJ
cord-259237-aty0vrat	323	9	labs	lab	NNS
cord-259237-aty0vrat	323	10	determining	determine	VBG
cord-259237-aty0vrat	323	11	colocalization	colocalization	NN
cord-259237-aty0vrat	323	12	with	with	IN
cord-259237-aty0vrat	323	13	the	the	DT
cord-259237-aty0vrat	323	14	ER	ER	NNP
cord-259237-aty0vrat	323	15	,	,	,
cord-259237-aty0vrat	323	16	Golgi	Golgi	NNP
cord-259237-aty0vrat	323	17	,	,	,
cord-259237-aty0vrat	323	18	or	or	CC
cord-259237-aty0vrat	323	19	ER	ER	NNP
cord-259237-aty0vrat	323	20	-	-	HYPH
cord-259237-aty0vrat	323	21	Golgi	golgi	NN
cord-259237-aty0vrat	323	22	intermediate	intermediate	JJ
cord-259237-aty0vrat	323	23	compartments	compartment	NNS
cord-259237-aty0vrat	323	24	and	and	CC
cord-259237-aty0vrat	323	25	quality	quality	NN
cord-259237-aty0vrat	323	26	control	control	NN
cord-259237-aty0vrat	323	27	vesicles	vesicle	NNS
cord-259237-aty0vrat	323	28	,	,	,
cord-259237-aty0vrat	323	29	lends	lend	VBZ
cord-259237-aty0vrat	323	30	credence	credence	NN
cord-259237-aty0vrat	323	31	to	to	IN
cord-259237-aty0vrat	323	32	both	both	CC
cord-259237-aty0vrat	323	33	current	current	JJ
cord-259237-aty0vrat	323	34	theories	theory	NNS
cord-259237-aty0vrat	323	35	that	that	IN
cord-259237-aty0vrat	323	36	ERManI	ERManI	NNP
cord-259237-aty0vrat	323	37	is	be	VBZ
cord-259237-aty0vrat	323	38	either	either	CC
cord-259237-aty0vrat	323	39	a	a	DT
cord-259237-aty0vrat	323	40	Golgi	Golgi	NNP
cord-259237-aty0vrat	323	41	checkpoint	checkpoint	NN
cord-259237-aty0vrat	323	42	in	in	IN
cord-259237-aty0vrat	323	43	quality	quality	NN
cord-259237-aty0vrat	323	44	control	control	NN
cord-259237-aty0vrat	323	45	that	that	WDT
cord-259237-aty0vrat	323	46	will	will	MD
cord-259237-aty0vrat	323	47	return	return	VB
cord-259237-aty0vrat	323	48	misfolded	misfolded	JJ
cord-259237-aty0vrat	323	49	proteins	protein	NNS
cord-259237-aty0vrat	323	50	back	back	RB
cord-259237-aty0vrat	323	51	to	to	IN
cord-259237-aty0vrat	323	52	the	the	DT
cord-259237-aty0vrat	323	53	ER	ER	NNP
cord-259237-aty0vrat	323	54	for	for	IN
cord-259237-aty0vrat	323	55	further	further	JJ
cord-259237-aty0vrat	323	56	processing	processing	NN
cord-259237-aty0vrat	323	57	,	,	,
cord-259237-aty0vrat	323	58	or	or	CC
cord-259237-aty0vrat	323	59	that	that	IN
cord-259237-aty0vrat	323	60	it	-PRON-	PRP
cord-259237-aty0vrat	323	61	resides	reside	VBZ
cord-259237-aty0vrat	323	62	in	in	IN
cord-259237-aty0vrat	323	63	quality	quality	NN
cord-259237-aty0vrat	323	64	control	control	NN
cord-259237-aty0vrat	323	65	vesicles	vesicle	NNS
cord-259237-aty0vrat	323	66	with	with	IN
cord-259237-aty0vrat	323	67	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	323	68	substrates	substrate	NNS
cord-259237-aty0vrat	323	69	as	as	IN
cord-259237-aty0vrat	323	70	part	part	NN
cord-259237-aty0vrat	323	71	of	of	IN
cord-259237-aty0vrat	323	72	the	the	DT
cord-259237-aty0vrat	323	73	CNX	CNX	NNP
cord-259237-aty0vrat	323	74	/	/	SYM
cord-259237-aty0vrat	323	75	CRT	CRT	NNP
cord-259237-aty0vrat	323	76	cycle	cycle	NN
cord-259237-aty0vrat	323	77	[	[	-LRB-
cord-259237-aty0vrat	323	78	24	24	CD
cord-259237-aty0vrat	323	79	,	,	,
cord-259237-aty0vrat	323	80	165	165	CD
cord-259237-aty0vrat	323	81	]	]	-RRB-
cord-259237-aty0vrat	323	82	.	.	.
cord-259237-aty0vrat	324	1	It	-PRON-	PRP
cord-259237-aty0vrat	324	2	is	be	VBZ
cord-259237-aty0vrat	324	3	well	well	RB
cord-259237-aty0vrat	324	4	established	establish	VBN
cord-259237-aty0vrat	324	5	that	that	IN
cord-259237-aty0vrat	324	6	viruses	virus	NNS
cord-259237-aty0vrat	324	7	have	have	VBP
cord-259237-aty0vrat	324	8	evolved	evolve	VBN
cord-259237-aty0vrat	324	9	to	to	TO
cord-259237-aty0vrat	324	10	manipulate	manipulate	VB
cord-259237-aty0vrat	324	11	host	host	NN
cord-259237-aty0vrat	324	12	UPR	UPR	NNP
cord-259237-aty0vrat	324	13	and	and	CC
cord-259237-aty0vrat	324	14	ERAD	ERAD	NNP
cord-259237-aty0vrat	324	15	to	to	TO
cord-259237-aty0vrat	324	16	optimize	optimize	VB
cord-259237-aty0vrat	324	17	their	-PRON-	PRP$
cord-259237-aty0vrat	324	18	replication	replication	NN
cord-259237-aty0vrat	324	19	,	,	,
cord-259237-aty0vrat	324	20	whether	whether	IN
cord-259237-aty0vrat	324	21	they	-PRON-	PRP
cord-259237-aty0vrat	324	22	are	be	VBP
cord-259237-aty0vrat	324	23	'	'	``
cord-259237-aty0vrat	324	24	tuning	tune	VBG
cord-259237-aty0vrat	324	25	'	'	''
cord-259237-aty0vrat	324	26	host	host	NN
cord-259237-aty0vrat	324	27	quality	quality	NN
cord-259237-aty0vrat	324	28	control	control	NN
cord-259237-aty0vrat	324	29	to	to	TO
cord-259237-aty0vrat	324	30	ensure	ensure	VB
cord-259237-aty0vrat	324	31	the	the	DT
cord-259237-aty0vrat	324	32	proper	proper	JJ
cord-259237-aty0vrat	324	33	folding	folding	NN
cord-259237-aty0vrat	324	34	of	of	IN
cord-259237-aty0vrat	324	35	their	-PRON-	PRP$
cord-259237-aty0vrat	324	36	envelope	envelope	NN
cord-259237-aty0vrat	324	37	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	324	38	,	,	,
cord-259237-aty0vrat	324	39	circumventing	circumvent	VBG
cord-259237-aty0vrat	324	40	ERAD	ERAD	NNP
cord-259237-aty0vrat	324	41	in	in	IN
cord-259237-aty0vrat	324	42	order	order	NN
cord-259237-aty0vrat	324	43	to	to	TO
cord-259237-aty0vrat	324	44	prevent	prevent	VB
cord-259237-aty0vrat	324	45	degradation	degradation	NN
cord-259237-aty0vrat	324	46	of	of	IN
cord-259237-aty0vrat	324	47	their	-PRON-	PRP$
cord-259237-aty0vrat	324	48	viral	viral	JJ
cord-259237-aty0vrat	324	49	envelope	envelope	NN
cord-259237-aty0vrat	324	50	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	324	51	,	,	,
cord-259237-aty0vrat	324	52	or	or	CC
cord-259237-aty0vrat	324	53	hijacking	hijacking	NN
cord-259237-aty0vrat	324	54	ERAD	ERAD	NNP
cord-259237-aty0vrat	324	55	to	to	TO
cord-259237-aty0vrat	324	56	dispose	dispose	VB
cord-259237-aty0vrat	324	57	of	of	IN
cord-259237-aty0vrat	324	58	host	host	NN
cord-259237-aty0vrat	324	59	proteins	protein	NNS
cord-259237-aty0vrat	324	60	.	.	.
cord-259237-aty0vrat	325	1	There	there	EX
cord-259237-aty0vrat	325	2	are	be	VBP
cord-259237-aty0vrat	325	3	still	still	RB
cord-259237-aty0vrat	325	4	many	many	JJ
cord-259237-aty0vrat	325	5	questions	question	NNS
cord-259237-aty0vrat	325	6	left	leave	VBN
cord-259237-aty0vrat	325	7	to	to	TO
cord-259237-aty0vrat	325	8	be	be	VB
cord-259237-aty0vrat	325	9	answered	answer	VBN
cord-259237-aty0vrat	325	10	,	,	,
cord-259237-aty0vrat	325	11	including	include	VBG
cord-259237-aty0vrat	325	12	the	the	DT
cord-259237-aty0vrat	325	13	identities	identity	NNS
cord-259237-aty0vrat	325	14	of	of	IN
cord-259237-aty0vrat	325	15	the	the	DT
cord-259237-aty0vrat	325	16	dislocons	dislocon	NNS
cord-259237-aty0vrat	325	17	that	that	IN
cord-259237-aty0vrat	325	18	each	each	DT
cord-259237-aty0vrat	325	19	envelope	envelope	NN
cord-259237-aty0vrat	325	20	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	325	21	is	be	VBZ
cord-259237-aty0vrat	325	22	targeted	target	VBN
cord-259237-aty0vrat	325	23	to	to	IN
cord-259237-aty0vrat	325	24	,	,	,
cord-259237-aty0vrat	325	25	the	the	DT
cord-259237-aty0vrat	325	26	motifs	motif	NNS
cord-259237-aty0vrat	325	27	or	or	CC
cord-259237-aty0vrat	325	28	patterns	pattern	NNS
cord-259237-aty0vrat	325	29	that	that	WDT
cord-259237-aty0vrat	325	30	allow	allow	VBP
cord-259237-aty0vrat	325	31	α1,2-mannosidases	α1,2-mannosidases	PRP
cord-259237-aty0vrat	325	32	to	to	TO
cord-259237-aty0vrat	325	33	differentiate	differentiate	VB
cord-259237-aty0vrat	325	34	between	between	IN
cord-259237-aty0vrat	325	35	native	native	JJ
cord-259237-aty0vrat	325	36	and	and	CC
cord-259237-aty0vrat	325	37	misfolded	misfolde	VBN
cord-259237-aty0vrat	325	38	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	325	39	,	,	,
cord-259237-aty0vrat	325	40	why	why	WRB
cord-259237-aty0vrat	325	41	some	some	DT
cord-259237-aty0vrat	325	42	viral	viral	JJ
cord-259237-aty0vrat	325	43	proteins	protein	NNS
cord-259237-aty0vrat	325	44	are	be	VBP
cord-259237-aty0vrat	325	45	disproportionately	disproportionately	RB
cord-259237-aty0vrat	325	46	targeted	target	VBN
cord-259237-aty0vrat	325	47	(	(	-LRB-
cord-259237-aty0vrat	325	48	HCMV	HCMV	NNP
cord-259237-aty0vrat	325	49	gH	gH	NNP
cord-259237-aty0vrat	325	50	)	)	-RRB-
cord-259237-aty0vrat	325	51	,	,	,
cord-259237-aty0vrat	325	52	and	and	CC
cord-259237-aty0vrat	325	53	the	the	DT
cord-259237-aty0vrat	325	54	roles	role	NNS
cord-259237-aty0vrat	325	55	that	that	WDT
cord-259237-aty0vrat	325	56	the	the	DT
cord-259237-aty0vrat	325	57	UPR	UPR	NNP
cord-259237-aty0vrat	325	58	and	and	CC
cord-259237-aty0vrat	325	59	ERAD	ERAD	NNP
cord-259237-aty0vrat	325	60	play	play	VBP
cord-259237-aty0vrat	325	61	in	in	IN
cord-259237-aty0vrat	325	62	vivo	vivo	NN
cord-259237-aty0vrat	325	63	during	during	IN
cord-259237-aty0vrat	325	64	viral	viral	JJ
cord-259237-aty0vrat	325	65	infections	infection	NNS
cord-259237-aty0vrat	325	66	.	.	.
cord-259237-aty0vrat	326	1	These	these	DT
cord-259237-aty0vrat	326	2	exciting	exciting	JJ
cord-259237-aty0vrat	326	3	areas	area	NNS
cord-259237-aty0vrat	326	4	merit	merit	VBP
cord-259237-aty0vrat	326	5	more	more	RBR
cord-259237-aty0vrat	326	6	extensive	extensive	JJ
cord-259237-aty0vrat	326	7	studies	study	NNS
cord-259237-aty0vrat	326	8	.	.	.
cord-259237-aty0vrat	327	1	Virus	virus	NN
cord-259237-aty0vrat	327	2	entry	entry	NN
cord-259237-aty0vrat	327	3	:	:	:
cord-259237-aty0vrat	327	4	Molecular	molecular	JJ
cord-259237-aty0vrat	327	5	mechanisms	mechanism	NNS
cord-259237-aty0vrat	327	6	and	and	CC
cord-259237-aty0vrat	327	7	biomedical	biomedical	JJ
cord-259237-aty0vrat	327	8	applications	application	NNS
cord-259237-aty0vrat	328	1	The	the	DT
cord-259237-aty0vrat	328	2	cell	cell	NN
cord-259237-aty0vrat	328	3	biology	biology	NN
cord-259237-aty0vrat	328	4	of	of	IN
cord-259237-aty0vrat	328	5	receptor	receptor	NN
cord-259237-aty0vrat	328	6	-	-	HYPH
cord-259237-aty0vrat	328	7	mediated	mediate	VBN
cord-259237-aty0vrat	328	8	virus	virus	NN
cord-259237-aty0vrat	328	9	entry	entry	NN
cord-259237-aty0vrat	328	10	Recruitment	Recruitment	NNP
cord-259237-aty0vrat	328	11	of	of	IN
cord-259237-aty0vrat	328	12	HIV	HIV	NNP
cord-259237-aty0vrat	328	13	and	and	CC
cord-259237-aty0vrat	328	14	its	-PRON-	PRP$
cord-259237-aty0vrat	328	15	receptors	receptor	NNS
cord-259237-aty0vrat	328	16	to	to	IN
cord-259237-aty0vrat	328	17	dendritic	dendritic	JJ
cord-259237-aty0vrat	328	18	cell	cell	NN
cord-259237-aty0vrat	328	19	-	-	HYPH
cord-259237-aty0vrat	328	20	T	t	NN
cord-259237-aty0vrat	328	21	cell	cell	NN
cord-259237-aty0vrat	328	22	junctions	junction	NNS
cord-259237-aty0vrat	328	23	Penetration	penetration	NN
cord-259237-aty0vrat	328	24	of	of	IN
cord-259237-aty0vrat	328	25	nonenveloped	nonenveloped	JJ
cord-259237-aty0vrat	328	26	viruses	virus	NNS
cord-259237-aty0vrat	328	27	into	into	IN
cord-259237-aty0vrat	328	28	the	the	DT
cord-259237-aty0vrat	328	29	cytoplasm	cytoplasm	JJ
cord-259237-aty0vrat	328	30	Virus	virus	NN
cord-259237-aty0vrat	328	31	and	and	CC
cord-259237-aty0vrat	328	32	cell	cell	NN
cord-259237-aty0vrat	328	33	fusion	fusion	NN
cord-259237-aty0vrat	328	34	mechanisms	mechanism	NNS
cord-259237-aty0vrat	329	1	Both	both	DT
cord-259237-aty0vrat	329	2	E	e	NN
cord-259237-aty0vrat	329	3	protein	protein	NN
cord-259237-aty0vrat	329	4	glycans	glycan	NNS
cord-259237-aty0vrat	329	5	adversely	adversely	RB
cord-259237-aty0vrat	329	6	affect	affect	VBP
cord-259237-aty0vrat	329	7	dengue	dengue	NN
cord-259237-aty0vrat	329	8	virus	virus	NN
cord-259237-aty0vrat	329	9	infectivity	infectivity	NN
cord-259237-aty0vrat	329	10	but	but	CC
cord-259237-aty0vrat	329	11	are	be	VBP
cord-259237-aty0vrat	329	12	beneficial	beneficial	JJ
cord-259237-aty0vrat	329	13	for	for	IN
cord-259237-aty0vrat	329	14	virion	virion	NN
cord-259237-aty0vrat	329	15	release	release	VB
cord-259237-aty0vrat	329	16	A	a	DT
cord-259237-aty0vrat	329	17	systematic	systematic	JJ
cord-259237-aty0vrat	329	18	study	study	NN
cord-259237-aty0vrat	329	19	of	of	IN
cord-259237-aty0vrat	329	20	the	the	DT
cord-259237-aty0vrat	329	21	N	n	CD
cord-259237-aty0vrat	329	22	-	-	HYPH
cord-259237-aty0vrat	329	23	glycosylation	glycosylation	NN
cord-259237-aty0vrat	329	24	sites	site	NNS
cord-259237-aty0vrat	329	25	of	of	IN
cord-259237-aty0vrat	329	26	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	329	27	envelope	envelope	NN
cord-259237-aty0vrat	329	28	protein	protein	NN
cord-259237-aty0vrat	329	29	on	on	IN
cord-259237-aty0vrat	329	30	infectivity	infectivity	NN
cord-259237-aty0vrat	329	31	and	and	CC
cord-259237-aty0vrat	329	32	antibody	antibody	NN
cord-259237-aty0vrat	329	33	-	-	HYPH
cord-259237-aty0vrat	329	34	mediated	mediate	VBN
cord-259237-aty0vrat	329	35	neutralization	neutralization	NN
cord-259237-aty0vrat	329	36	Playing	play	VBG
cord-259237-aty0vrat	329	37	hide	hide	VB
cord-259237-aty0vrat	329	38	and	and	CC
cord-259237-aty0vrat	329	39	seek	seek	VB
cord-259237-aty0vrat	329	40	:	:	:
cord-259237-aty0vrat	329	41	How	how	WRB
cord-259237-aty0vrat	329	42	glycosylation	glycosylation	NN
cord-259237-aty0vrat	329	43	of	of	IN
cord-259237-aty0vrat	329	44	the	the	DT
cord-259237-aty0vrat	329	45	influenza	influenza	NN
cord-259237-aty0vrat	329	46	virus	virus	NN
cord-259237-aty0vrat	329	47	hemagglutinin	hemagglutinin	NNS
cord-259237-aty0vrat	329	48	can	can	MD
cord-259237-aty0vrat	329	49	modulate	modulate	VB
cord-259237-aty0vrat	329	50	the	the	DT
cord-259237-aty0vrat	329	51	immune	immune	JJ
cord-259237-aty0vrat	329	52	response	response	NN
cord-259237-aty0vrat	329	53	to	to	IN
cord-259237-aty0vrat	329	54	infection	infection	NN
cord-259237-aty0vrat	330	1	The	the	DT
cord-259237-aty0vrat	330	2	hepatitis	hepatitis	NN
cord-259237-aty0vrat	330	3	C	c	NN
cord-259237-aty0vrat	330	4	virus	virus	NN
cord-259237-aty0vrat	330	5	glycan	glycan	NN
cord-259237-aty0vrat	330	6	shield	shield	NN
cord-259237-aty0vrat	330	7	and	and	CC
cord-259237-aty0vrat	330	8	evasion	evasion	NN
cord-259237-aty0vrat	330	9	of	of	IN
cord-259237-aty0vrat	330	10	the	the	DT
cord-259237-aty0vrat	330	11	humoral	humoral	JJ
cord-259237-aty0vrat	330	12	immune	immune	JJ
cord-259237-aty0vrat	330	13	response	response	NN
cord-259237-aty0vrat	330	14	Comprehensive	comprehensive	JJ
cord-259237-aty0vrat	330	15	functional	functional	JJ
cord-259237-aty0vrat	330	16	analysis	analysis	NN
cord-259237-aty0vrat	330	17	of	of	IN
cord-259237-aty0vrat	330	18	N	n	NN
cord-259237-aty0vrat	330	19	-	-	HYPH
cord-259237-aty0vrat	330	20	linked	link	VBN
cord-259237-aty0vrat	330	21	glycans	glycan	NNS
cord-259237-aty0vrat	330	22	on	on	IN
cord-259237-aty0vrat	330	23	Ebola	Ebola	NNP
cord-259237-aty0vrat	330	24	virus	virus	NN
cord-259237-aty0vrat	331	1	GP1	GP1	NNP
cord-259237-aty0vrat	331	2	Tracking	track	VBG
cord-259237-aty0vrat	331	3	global	global	JJ
cord-259237-aty0vrat	331	4	patterns	pattern	NNS
cord-259237-aty0vrat	331	5	of	of	IN
cord-259237-aty0vrat	331	6	n	n	RB
cord-259237-aty0vrat	331	7	-	-	HYPH
cord-259237-aty0vrat	331	8	linked	link	VBN
cord-259237-aty0vrat	331	9	glycosylation	glycosylation	NN
cord-259237-aty0vrat	331	10	site	site	NN
cord-259237-aty0vrat	331	11	variation	variation	NN
cord-259237-aty0vrat	331	12	in	in	IN
cord-259237-aty0vrat	331	13	highly	highly	RB
cord-259237-aty0vrat	331	14	variable	variable	JJ
cord-259237-aty0vrat	331	15	viral	viral	JJ
cord-259237-aty0vrat	331	16	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	331	17	:	:	:
cord-259237-aty0vrat	331	18	HIV	HIV	NNP
cord-259237-aty0vrat	331	19	,	,	,
cord-259237-aty0vrat	331	20	SIV	SIV	NNP
cord-259237-aty0vrat	331	21	,	,	,
cord-259237-aty0vrat	331	22	and	and	CC
cord-259237-aty0vrat	331	23	HCV	HCV	NNP
cord-259237-aty0vrat	331	24	envelopes	envelope	NNS
cord-259237-aty0vrat	331	25	and	and	CC
cord-259237-aty0vrat	331	26	influenza	influenza	NN
cord-259237-aty0vrat	331	27	hemagglutinin	hemagglutinin	NN
cord-259237-aty0vrat	331	28	Glycosylation	Glycosylation	NNP
cord-259237-aty0vrat	331	29	affects	affect	VBZ
cord-259237-aty0vrat	331	30	cleavage	cleavage	NN
cord-259237-aty0vrat	331	31	of	of	IN
cord-259237-aty0vrat	331	32	an	an	DT
cord-259237-aty0vrat	331	33	H5N2	H5N2	NNP
cord-259237-aty0vrat	331	34	influenza	influenza	NN
cord-259237-aty0vrat	331	35	virus	virus	NN
cord-259237-aty0vrat	331	36	hemagglutinin	hemagglutinin	NN
cord-259237-aty0vrat	331	37	and	and	CC
cord-259237-aty0vrat	331	38	regulates	regulate	VBZ
cord-259237-aty0vrat	331	39	virulence	virulence	NN
cord-259237-aty0vrat	331	40	Importance	importance	NN
cord-259237-aty0vrat	331	41	of	of	IN
cord-259237-aty0vrat	331	42	hemagglutinin	hemagglutinin	NN
cord-259237-aty0vrat	331	43	glycosylation	glycosylation	NN
cord-259237-aty0vrat	331	44	for	for	IN
cord-259237-aty0vrat	331	45	the	the	DT
cord-259237-aty0vrat	331	46	biological	biological	JJ
cord-259237-aty0vrat	331	47	functions	function	NNS
cord-259237-aty0vrat	331	48	of	of	IN
cord-259237-aty0vrat	331	49	influenza	influenza	NN
cord-259237-aty0vrat	331	50	virus	virus	NN
cord-259237-aty0vrat	331	51	Interdependence	Interdependence	NNP
cord-259237-aty0vrat	331	52	of	of	IN
cord-259237-aty0vrat	331	53	hemagglutinin	hemagglutinin	NN
cord-259237-aty0vrat	331	54	glycosylation	glycosylation	NN
cord-259237-aty0vrat	331	55	and	and	CC
cord-259237-aty0vrat	331	56	neuraminidase	neuraminidase	NN
cord-259237-aty0vrat	331	57	as	as	IN
cord-259237-aty0vrat	331	58	regulators	regulator	NNS
cord-259237-aty0vrat	331	59	of	of	IN
cord-259237-aty0vrat	331	60	influenza	influenza	NN
cord-259237-aty0vrat	331	61	virus	virus	NN
cord-259237-aty0vrat	331	62	growth	growth	NN
cord-259237-aty0vrat	331	63	:	:	:
cord-259237-aty0vrat	331	64	A	a	DT
cord-259237-aty0vrat	331	65	study	study	NN
cord-259237-aty0vrat	331	66	by	by	IN
cord-259237-aty0vrat	331	67	reverse	reverse	JJ
cord-259237-aty0vrat	331	68	genetics	genetic	NNS
cord-259237-aty0vrat	332	1	The	the	DT
cord-259237-aty0vrat	332	2	HIV	HIV	NNP
cord-259237-aty0vrat	332	3	glycan	glycan	NN
cord-259237-aty0vrat	332	4	shield	shield	NN
cord-259237-aty0vrat	332	5	as	as	IN
cord-259237-aty0vrat	332	6	a	a	DT
cord-259237-aty0vrat	332	7	target	target	NN
cord-259237-aty0vrat	332	8	for	for	IN
cord-259237-aty0vrat	332	9	broadly	broadly	RB
cord-259237-aty0vrat	332	10	neutralizing	neutralize	VBG
cord-259237-aty0vrat	332	11	antibodies	antibody	NNS
cord-259237-aty0vrat	332	12	Virus	virus	NN
cord-259237-aty0vrat	332	13	glycosylation	glycosylation	NN
cord-259237-aty0vrat	332	14	:	:	:
cord-259237-aty0vrat	332	15	Role	role	NN
cord-259237-aty0vrat	332	16	in	in	IN
cord-259237-aty0vrat	332	17	virulence	virulence	NN
cord-259237-aty0vrat	332	18	and	and	CC
cord-259237-aty0vrat	332	19	immune	immune	JJ
cord-259237-aty0vrat	332	20	interactions	interaction	NNS
cord-259237-aty0vrat	332	21	Vertebrate	vertebrate	JJ
cord-259237-aty0vrat	332	22	protein	protein	NN
cord-259237-aty0vrat	332	23	glycosylation	glycosylation	NN
cord-259237-aty0vrat	332	24	:	:	:
cord-259237-aty0vrat	332	25	Diversity	diversity	NN
cord-259237-aty0vrat	332	26	,	,	,
cord-259237-aty0vrat	332	27	synthesis	synthesis	NN
cord-259237-aty0vrat	332	28	and	and	CC
cord-259237-aty0vrat	332	29	function	function	NN
cord-259237-aty0vrat	332	30	Roles	Roles	NNPS
cord-259237-aty0vrat	332	31	of	of	IN
cord-259237-aty0vrat	332	32	N	N	NNP
cord-259237-aty0vrat	332	33	-	-	HYPH
cord-259237-aty0vrat	332	34	linked	link	VBN
cord-259237-aty0vrat	332	35	glycans	glycan	NNS
cord-259237-aty0vrat	332	36	in	in	IN
cord-259237-aty0vrat	332	37	the	the	DT
cord-259237-aty0vrat	332	38	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	332	39	reticulum	reticulum	NN
cord-259237-aty0vrat	332	40	N	n	CD
cord-259237-aty0vrat	332	41	-	-	HYPH
cord-259237-aty0vrat	332	42	glycan	glycan	NN
cord-259237-aty0vrat	332	43	-	-	HYPH
cord-259237-aty0vrat	332	44	based	base	VBN
cord-259237-aty0vrat	332	45	ER	ER	NNP
cord-259237-aty0vrat	332	46	molecular	molecular	JJ
cord-259237-aty0vrat	332	47	chaperone	chaperone	NN
cord-259237-aty0vrat	332	48	and	and	CC
cord-259237-aty0vrat	332	49	protein	protein	NN
cord-259237-aty0vrat	332	50	quality	quality	NN
cord-259237-aty0vrat	332	51	control	control	NN
cord-259237-aty0vrat	332	52	system	system	NN
cord-259237-aty0vrat	332	53	:	:	:
cord-259237-aty0vrat	332	54	The	the	DT
cord-259237-aty0vrat	332	55	calnexin	calnexin	JJ
cord-259237-aty0vrat	332	56	binding	binding	NN
cord-259237-aty0vrat	332	57	cycle	cycle	NN
cord-259237-aty0vrat	332	58	Malectin	Malectin	NNP
cord-259237-aty0vrat	332	59	:	:	:
cord-259237-aty0vrat	333	1	A	a	DT
cord-259237-aty0vrat	333	2	novel	novel	JJ
cord-259237-aty0vrat	333	3	carbohydrate	carbohydrate	NN
cord-259237-aty0vrat	333	4	-	-	HYPH
cord-259237-aty0vrat	333	5	binding	bind	VBG
cord-259237-aty0vrat	333	6	protein	protein	NN
cord-259237-aty0vrat	333	7	of	of	IN
cord-259237-aty0vrat	333	8	the	the	DT
cord-259237-aty0vrat	333	9	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	333	10	reticulum	reticulum	NN
cord-259237-aty0vrat	333	11	and	and	CC
cord-259237-aty0vrat	333	12	a	a	DT
cord-259237-aty0vrat	333	13	candidate	candidate	NN
cord-259237-aty0vrat	333	14	player	player	NN
cord-259237-aty0vrat	333	15	in	in	IN
cord-259237-aty0vrat	333	16	the	the	DT
cord-259237-aty0vrat	333	17	early	early	JJ
cord-259237-aty0vrat	333	18	steps	step	NNS
cord-259237-aty0vrat	333	19	of	of	IN
cord-259237-aty0vrat	333	20	protein	protein	NN
cord-259237-aty0vrat	333	21	N	n	CD
cord-259237-aty0vrat	333	22	-	-	HYPH
cord-259237-aty0vrat	333	23	glycosylation	glycosylation	NN
cord-259237-aty0vrat	334	1	The	the	DT
cord-259237-aty0vrat	334	2	role	role	NN
cord-259237-aty0vrat	334	3	of	of	IN
cord-259237-aty0vrat	334	4	lectin	lectin	NN
cord-259237-aty0vrat	334	5	-	-	HYPH
cord-259237-aty0vrat	334	6	carbohydrate	carbohydrate	NN
cord-259237-aty0vrat	334	7	interactions	interaction	NNS
cord-259237-aty0vrat	334	8	in	in	IN
cord-259237-aty0vrat	334	9	the	the	DT
cord-259237-aty0vrat	334	10	regulation	regulation	NN
cord-259237-aty0vrat	334	11	of	of	IN
cord-259237-aty0vrat	334	12	ER	ER	NNP
cord-259237-aty0vrat	334	13	-	-	HYPH
cord-259237-aty0vrat	334	14	associated	associate	VBN
cord-259237-aty0vrat	334	15	protein	protein	NN
cord-259237-aty0vrat	334	16	degradation	degradation	NN
cord-259237-aty0vrat	335	1	The	the	DT
cord-259237-aty0vrat	335	2	long	long	JJ
cord-259237-aty0vrat	335	3	road	road	NN
cord-259237-aty0vrat	335	4	to	to	IN
cord-259237-aty0vrat	335	5	destruction	destruction	NN
cord-259237-aty0vrat	336	1	Mammalian	mammalian	JJ
cord-259237-aty0vrat	336	2	ER	ER	NNP
cord-259237-aty0vrat	336	3	mannosidase	mannosidase	NN
cord-259237-aty0vrat	337	1	I	-PRON-	PRP
cord-259237-aty0vrat	337	2	resides	reside	VBZ
cord-259237-aty0vrat	337	3	in	in	IN
cord-259237-aty0vrat	337	4	quality	quality	NN
cord-259237-aty0vrat	337	5	control	control	NN
cord-259237-aty0vrat	337	6	vesicles	vesicle	NNS
cord-259237-aty0vrat	337	7	,	,	,
cord-259237-aty0vrat	337	8	where	where	WRB
cord-259237-aty0vrat	337	9	it	-PRON-	PRP
cord-259237-aty0vrat	337	10	encounters	encounter	VBZ
cord-259237-aty0vrat	337	11	its	-PRON-	PRP$
cord-259237-aty0vrat	337	12	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	337	13	substrates	substrate	NNS
cord-259237-aty0vrat	337	14	The	the	DT
cord-259237-aty0vrat	337	15	specificity	specificity	NN
cord-259237-aty0vrat	337	16	of	of	IN
cord-259237-aty0vrat	337	17	the	the	DT
cord-259237-aty0vrat	337	18	yeast	yeast	NN
cord-259237-aty0vrat	337	19	and	and	CC
cord-259237-aty0vrat	337	20	human	human	JJ
cord-259237-aty0vrat	337	21	class	class	NN
cord-259237-aty0vrat	338	1	I	-PRON-	PRP
cord-259237-aty0vrat	338	2	ER	er	VBP
cord-259237-aty0vrat	338	3	alpha	alpha	NN
cord-259237-aty0vrat	338	4	1,2-mannosidases	1,2-mannosidases	CD
cord-259237-aty0vrat	339	1	involved	involve	VBN
cord-259237-aty0vrat	339	2	in	in	IN
cord-259237-aty0vrat	339	3	ER	ER	NNP
cord-259237-aty0vrat	339	4	quality	quality	NN
cord-259237-aty0vrat	339	5	control	control	NN
cord-259237-aty0vrat	339	6	is	be	VBZ
cord-259237-aty0vrat	339	7	not	not	RB
cord-259237-aty0vrat	339	8	as	as	RB
cord-259237-aty0vrat	339	9	strict	strict	JJ
cord-259237-aty0vrat	339	10	previously	previously	RB
cord-259237-aty0vrat	339	11	reported	report	VBD
cord-259237-aty0vrat	339	12	Endoplasmic	Endoplasmic	NNP
cord-259237-aty0vrat	339	13	reticulum	reticulum	NN
cord-259237-aty0vrat	339	14	-	-	HYPH
cord-259237-aty0vrat	339	15	associated	associate	VBN
cord-259237-aty0vrat	339	16	degradation	degradation	NN
cord-259237-aty0vrat	339	17	of	of	IN
cord-259237-aty0vrat	339	18	mammalian	mammalian	JJ
cord-259237-aty0vrat	339	19	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	339	20	involves	involve	VBZ
cord-259237-aty0vrat	339	21	sugar	sugar	NN
cord-259237-aty0vrat	339	22	chain	chain	NN
cord-259237-aty0vrat	339	23	trimming	trim	VBG
cord-259237-aty0vrat	339	24	to	to	IN
cord-259237-aty0vrat	339	25	Man6	Man6	NNP
cord-259237-aty0vrat	339	26	-	-	HYPH
cord-259237-aty0vrat	339	27	5GlcNAc2	5glcnac2	CD
cord-259237-aty0vrat	340	1	The	the	DT
cord-259237-aty0vrat	340	2	unfolded	unfolded	JJ
cord-259237-aty0vrat	340	3	protein	protein	NN
cord-259237-aty0vrat	340	4	response	response	NN
cord-259237-aty0vrat	340	5	:	:	:
cord-259237-aty0vrat	341	1	Integrating	integrate	VBG
cord-259237-aty0vrat	341	2	stress	stress	NN
cord-259237-aty0vrat	341	3	signals	signal	NNS
cord-259237-aty0vrat	341	4	through	through	IN
cord-259237-aty0vrat	341	5	the	the	DT
cord-259237-aty0vrat	341	6	stress	stress	NN
cord-259237-aty0vrat	341	7	sensor	sensor	NN
cord-259237-aty0vrat	341	8	IRE1alpha	IRE1alpha	NNP
cord-259237-aty0vrat	341	9	Endoplasmic	Endoplasmic	NNP
cord-259237-aty0vrat	341	10	reticulum	reticulum	NN
cord-259237-aty0vrat	341	11	stress	stress	NN
cord-259237-aty0vrat	341	12	sensing	sensing	NN
cord-259237-aty0vrat	341	13	in	in	IN
cord-259237-aty0vrat	341	14	the	the	DT
cord-259237-aty0vrat	341	15	unfolded	unfolded	JJ
cord-259237-aty0vrat	341	16	protein	protein	NN
cord-259237-aty0vrat	341	17	response	response	NN
cord-259237-aty0vrat	341	18	Dynamic	dynamic	JJ
cord-259237-aty0vrat	341	19	interaction	interaction	NN
cord-259237-aty0vrat	341	20	of	of	IN
cord-259237-aty0vrat	341	21	BIP	BIP	NNP
cord-259237-aty0vrat	341	22	and	and	CC
cord-259237-aty0vrat	341	23	ER	ER	NNP
cord-259237-aty0vrat	341	24	stress	stress	NN
cord-259237-aty0vrat	341	25	transducers	transducer	NNS
cord-259237-aty0vrat	341	26	in	in	IN
cord-259237-aty0vrat	341	27	the	the	DT
cord-259237-aty0vrat	341	28	unfolded	unfold	VBN
cord-259237-aty0vrat	341	29	-	-	HYPH
cord-259237-aty0vrat	341	30	protein	protein	NN
cord-259237-aty0vrat	341	31	response	response	NN
cord-259237-aty0vrat	342	1	The	the	DT
cord-259237-aty0vrat	342	2	unfolded	unfolded	JJ
cord-259237-aty0vrat	342	3	protein	protein	NN
cord-259237-aty0vrat	342	4	response	response	NN
cord-259237-aty0vrat	342	5	:	:	:
cord-259237-aty0vrat	342	6	From	from	IN
cord-259237-aty0vrat	342	7	stress	stress	NN
cord-259237-aty0vrat	342	8	pathway	pathway	NN
cord-259237-aty0vrat	342	9	to	to	IN
cord-259237-aty0vrat	342	10	homeostatic	homeostatic	JJ
cord-259237-aty0vrat	342	11	regulation	regulation	NN
cord-259237-aty0vrat	343	1	Unfolded	unfolded	JJ
cord-259237-aty0vrat	343	2	proteins	protein	NNS
cord-259237-aty0vrat	343	3	are	be	VBP
cord-259237-aty0vrat	343	4	Ire1-activating	ire1-activate	VBG
cord-259237-aty0vrat	343	5	ligands	ligand	NNS
cord-259237-aty0vrat	343	6	that	that	WDT
cord-259237-aty0vrat	343	7	directly	directly	RB
cord-259237-aty0vrat	343	8	induce	induce	VBP
cord-259237-aty0vrat	343	9	the	the	DT
cord-259237-aty0vrat	343	10	unfolded	unfold	VBN
cord-259237-aty0vrat	343	11	protein	protein	NN
cord-259237-aty0vrat	343	12	response	response	NN
cord-259237-aty0vrat	343	13	ER	er	NN
cord-259237-aty0vrat	343	14	-	-	HYPH
cord-259237-aty0vrat	343	15	stress	stress	NN
cord-259237-aty0vrat	343	16	-	-	HYPH
cord-259237-aty0vrat	343	17	induced	induce	VBN
cord-259237-aty0vrat	343	18	transcriptional	transcriptional	JJ
cord-259237-aty0vrat	343	19	regulation	regulation	NN
cord-259237-aty0vrat	343	20	increases	increase	VBZ
cord-259237-aty0vrat	343	21	protein	protein	NN
cord-259237-aty0vrat	343	22	synthesis	synthesis	NN
cord-259237-aty0vrat	343	23	leading	lead	VBG
cord-259237-aty0vrat	343	24	to	to	IN
cord-259237-aty0vrat	343	25	cell	cell	NN
cord-259237-aty0vrat	343	26	death	death	NN
cord-259237-aty0vrat	343	27	Endoplasmic	Endoplasmic	NNP
cord-259237-aty0vrat	343	28	reticulum	reticulum	NN
cord-259237-aty0vrat	343	29	-	-	HYPH
cord-259237-aty0vrat	343	30	associated	associate	VBN
cord-259237-aty0vrat	343	31	degradation	degradation	NN
cord-259237-aty0vrat	343	32	Regulation	regulation	NN
cord-259237-aty0vrat	343	33	of	of	IN
cord-259237-aty0vrat	343	34	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	343	35	reticulum	reticulum	NN
cord-259237-aty0vrat	343	36	-	-	HYPH
cord-259237-aty0vrat	343	37	associated	associate	VBN
cord-259237-aty0vrat	343	38	protein	protein	NN
cord-259237-aty0vrat	343	39	degradation	degradation	NN
cord-259237-aty0vrat	343	40	(	(	-LRB-
cord-259237-aty0vrat	343	41	ERAD	ERAD	NNP
cord-259237-aty0vrat	343	42	)	)	-RRB-
cord-259237-aty0vrat	343	43	by	by	IN
cord-259237-aty0vrat	343	44	ubiquitin	ubiquitin	NNP
cord-259237-aty0vrat	343	45	.	.	.
cord-259237-aty0vrat	344	1	Cells	cell	NNS
cord-259237-aty0vrat	345	1	How	how	WRB
cord-259237-aty0vrat	345	2	early	early	JJ
cord-259237-aty0vrat	345	3	studies	study	NNS
cord-259237-aty0vrat	345	4	on	on	IN
cord-259237-aty0vrat	345	5	secreted	secrete	VBN
cord-259237-aty0vrat	345	6	and	and	CC
cord-259237-aty0vrat	345	7	membrane	membrane	NN
cord-259237-aty0vrat	345	8	protein	protein	NN
cord-259237-aty0vrat	345	9	quality	quality	NN
cord-259237-aty0vrat	345	10	control	control	NN
cord-259237-aty0vrat	345	11	gave	give	VBD
cord-259237-aty0vrat	345	12	rise	rise	NN
cord-259237-aty0vrat	345	13	to	to	IN
cord-259237-aty0vrat	345	14	the	the	DT
cord-259237-aty0vrat	345	15	ER	ER	NNP
cord-259237-aty0vrat	345	16	associated	associate	VBN
cord-259237-aty0vrat	345	17	degradation	degradation	NN
cord-259237-aty0vrat	345	18	(	(	-LRB-
cord-259237-aty0vrat	345	19	ERAD	ERAD	NNP
cord-259237-aty0vrat	345	20	)	)	-RRB-
cord-259237-aty0vrat	345	21	pathway	pathway	NN
cord-259237-aty0vrat	345	22	:	:	:
cord-259237-aty0vrat	346	1	The	the	DT
cord-259237-aty0vrat	346	2	early	early	JJ
cord-259237-aty0vrat	346	3	history	history	NN
cord-259237-aty0vrat	346	4	of	of	IN
cord-259237-aty0vrat	346	5	erad	erad	NNP
cord-259237-aty0vrat	346	6	Sterol	Sterol	NNP
cord-259237-aty0vrat	346	7	homeostasis	homeostasis	NN
cord-259237-aty0vrat	346	8	requires	require	VBZ
cord-259237-aty0vrat	346	9	regulated	regulate	VBN
cord-259237-aty0vrat	346	10	degradation	degradation	NN
cord-259237-aty0vrat	346	11	of	of	IN
cord-259237-aty0vrat	346	12	squalene	squalene	NN
cord-259237-aty0vrat	346	13	monooxygenase	monooxygenase	NN
cord-259237-aty0vrat	346	14	by	by	IN
cord-259237-aty0vrat	346	15	the	the	DT
cord-259237-aty0vrat	346	16	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	346	17	ligase	ligase	NN
cord-259237-aty0vrat	346	18	Doa10	Doa10	NNP
cord-259237-aty0vrat	346	19	/	/	SYM
cord-259237-aty0vrat	346	20	Teb4	Teb4	NNP
cord-259237-aty0vrat	346	21	.	.	.
cord-259237-aty0vrat	347	1	eLife	eLife	NNP
cord-259237-aty0vrat	347	2	2013	2013	CD
cord-259237-aty0vrat	347	3	,	,	,
cord-259237-aty0vrat	347	4	2	2	CD
cord-259237-aty0vrat	347	5	,	,	,
cord-259237-aty0vrat	347	6	e00953	e00953	NNS
cord-259237-aty0vrat	348	1	When	when	WRB
cord-259237-aty0vrat	348	2	worlds	world	NNS
cord-259237-aty0vrat	348	3	collide	collide	VBP
cord-259237-aty0vrat	348	4	:	:	:
cord-259237-aty0vrat	348	5	Ip(3	ip(3	CD
cord-259237-aty0vrat	348	6	)	)	-RRB-
cord-259237-aty0vrat	348	7	receptors	receptor	NNS
cord-259237-aty0vrat	348	8	and	and	CC
cord-259237-aty0vrat	348	9	the	the	DT
cord-259237-aty0vrat	348	10	ERAD	ERAD	NNP
cord-259237-aty0vrat	348	11	pathway	pathway	NN
cord-259237-aty0vrat	348	12	Regulation	regulation	NN
cord-259237-aty0vrat	348	13	of	of	IN
cord-259237-aty0vrat	348	14	diacylglycerol	diacylglycerol	NN
cord-259237-aty0vrat	348	15	acyltransferase	acyltransferase	NNP
cord-259237-aty0vrat	348	16	2	2	CD
cord-259237-aty0vrat	348	17	protein	protein	NN
cord-259237-aty0vrat	348	18	stability	stability	NN
cord-259237-aty0vrat	348	19	by	by	IN
cord-259237-aty0vrat	348	20	gp78-associated	gp78-associated	JJ
cord-259237-aty0vrat	348	21	endoplasmicreticulum	endoplasmicreticulum	NN
cord-259237-aty0vrat	348	22	-	-	HYPH
cord-259237-aty0vrat	348	23	associated	associate	VBN
cord-259237-aty0vrat	348	24	degradation	degradation	NN
cord-259237-aty0vrat	349	1	Ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	349	2	-	-	HYPH
cord-259237-aty0vrat	349	3	proteasome	proteasome	NN
cord-259237-aty0vrat	349	4	system	system	NN
cord-259237-aty0vrat	349	5	mediates	mediate	VBZ
cord-259237-aty0vrat	349	6	heme	heme	JJ
cord-259237-aty0vrat	349	7	oxygenase-1	oxygenase-1	NNP
cord-259237-aty0vrat	349	8	degradation	degradation	NN
cord-259237-aty0vrat	349	9	through	through	IN
cord-259237-aty0vrat	349	10	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	349	11	reticulum	reticulum	NN
cord-259237-aty0vrat	349	12	-	-	HYPH
cord-259237-aty0vrat	349	13	associated	associate	VBN
cord-259237-aty0vrat	349	14	degradation	degradation	NN
cord-259237-aty0vrat	349	15	pathway	pathway	NN
cord-259237-aty0vrat	349	16	Selective	selective	JJ
cord-259237-aty0vrat	349	17	inhibition	inhibition	NN
cord-259237-aty0vrat	349	18	of	of	IN
cord-259237-aty0vrat	349	19	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	349	20	reticulum	reticulum	NN
cord-259237-aty0vrat	349	21	-	-	HYPH
cord-259237-aty0vrat	349	22	associated	associate	VBN
cord-259237-aty0vrat	349	23	degradation	degradation	NN
cord-259237-aty0vrat	349	24	rescues	rescue	VBZ
cord-259237-aty0vrat	349	25	DeltaF508-cystic	deltaf508-cystic	POS
cord-259237-aty0vrat	349	26	fibrosis	fibrosis	NN
cord-259237-aty0vrat	349	27	transmembrane	transmembrane	NNP
cord-259237-aty0vrat	349	28	regulator	regulator	NN
cord-259237-aty0vrat	349	29	and	and	CC
cord-259237-aty0vrat	349	30	suppresses	suppress	VBZ
cord-259237-aty0vrat	349	31	interleukin-8	interleukin-8	JJ
cord-259237-aty0vrat	349	32	levels	level	NNS
cord-259237-aty0vrat	349	33	:	:	:
cord-259237-aty0vrat	350	1	Therapeutic	therapeutic	JJ
cord-259237-aty0vrat	350	2	implications	implication	NNS
cord-259237-aty0vrat	351	1	The	the	DT
cord-259237-aty0vrat	351	2	delicate	delicate	JJ
cord-259237-aty0vrat	351	3	balance	balance	NN
cord-259237-aty0vrat	351	4	between	between	IN
cord-259237-aty0vrat	351	5	secreted	secrete	VBN
cord-259237-aty0vrat	351	6	protein	protein	NN
cord-259237-aty0vrat	351	7	folding	folding	NN
cord-259237-aty0vrat	351	8	and	and	CC
cord-259237-aty0vrat	351	9	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	351	10	reticulum	reticulum	NN
cord-259237-aty0vrat	351	11	-	-	HYPH
cord-259237-aty0vrat	351	12	associated	associate	VBN
cord-259237-aty0vrat	351	13	degradation	degradation	NN
cord-259237-aty0vrat	351	14	in	in	IN
cord-259237-aty0vrat	351	15	human	human	JJ
cord-259237-aty0vrat	351	16	physiology	physiology	NN
cord-259237-aty0vrat	351	17	Flagging	flagging	NN
cord-259237-aty0vrat	351	18	and	and	CC
cord-259237-aty0vrat	351	19	docking	docking	NN
cord-259237-aty0vrat	351	20	:	:	:
cord-259237-aty0vrat	351	21	Dual	dual	JJ
cord-259237-aty0vrat	351	22	roles	role	NNS
cord-259237-aty0vrat	351	23	for	for	IN
cord-259237-aty0vrat	351	24	N	n	NN
cord-259237-aty0vrat	351	25	-	-	HYPH
cord-259237-aty0vrat	351	26	glycans	glycan	NNS
cord-259237-aty0vrat	351	27	in	in	IN
cord-259237-aty0vrat	351	28	protein	protein	NN
cord-259237-aty0vrat	351	29	quality	quality	NN
cord-259237-aty0vrat	351	30	control	control	NN
cord-259237-aty0vrat	351	31	and	and	CC
cord-259237-aty0vrat	352	1	cellular	cellular	JJ
cord-259237-aty0vrat	352	2	proteostasis	proteostasis	NNP
cord-259237-aty0vrat	352	3	Family	Family	NNP
cord-259237-aty0vrat	352	4	47	47	CD
cord-259237-aty0vrat	352	5	alpha	alpha	NN
cord-259237-aty0vrat	352	6	-	-	HYPH
cord-259237-aty0vrat	352	7	mannosidases	mannosidase	NNS
cord-259237-aty0vrat	352	8	in	in	IN
cord-259237-aty0vrat	352	9	N	n	CD
cord-259237-aty0vrat	352	10	-	-	HYPH
cord-259237-aty0vrat	352	11	glycan	glycan	NN
cord-259237-aty0vrat	352	12	processing	processing	NN
cord-259237-aty0vrat	352	13	EDEM2	edem2	NN
cord-259237-aty0vrat	352	14	initiates	initiate	VBZ
cord-259237-aty0vrat	352	15	mammalian	mammalian	JJ
cord-259237-aty0vrat	352	16	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	352	17	ERAD	ERAD	NNP
cord-259237-aty0vrat	352	18	by	by	IN
cord-259237-aty0vrat	352	19	catalyzing	catalyze	VBG
cord-259237-aty0vrat	352	20	the	the	DT
cord-259237-aty0vrat	352	21	first	first	JJ
cord-259237-aty0vrat	352	22	mannose	mannose	NN
cord-259237-aty0vrat	352	23	trimming	trimming	NN
cord-259237-aty0vrat	352	24	step	step	NN
cord-259237-aty0vrat	352	25	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	352	26	,	,	,
cord-259237-aty0vrat	352	27	a	a	DT
cord-259237-aty0vrat	352	28	soluble	soluble	JJ
cord-259237-aty0vrat	352	29	EDEM	EDEM	NNP
cord-259237-aty0vrat	352	30	homolog	homolog	NN
cord-259237-aty0vrat	352	31	,	,	,
cord-259237-aty0vrat	352	32	enhances	enhance	VBZ
cord-259237-aty0vrat	352	33	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	352	34	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	352	35	reticulumassociated	reticulumassociate	VBN
cord-259237-aty0vrat	352	36	degradation	degradation	NN
cord-259237-aty0vrat	352	37	and	and	CC
cord-259237-aty0vrat	352	38	mannose	mannose	NN
cord-259237-aty0vrat	352	39	trimming	trimming	NN
cord-259237-aty0vrat	352	40	In	in	IN
cord-259237-aty0vrat	352	41	vitro	vitro	FW
cord-259237-aty0vrat	352	42	mannose	mannose	NN
cord-259237-aty0vrat	352	43	trimming	trimming	NN
cord-259237-aty0vrat	352	44	property	property	NN
cord-259237-aty0vrat	352	45	of	of	IN
cord-259237-aty0vrat	352	46	human	human	JJ
cord-259237-aty0vrat	352	47	ER	ER	NNP
cord-259237-aty0vrat	352	48	alpha-1,2	alpha-1,2	NNP
cord-259237-aty0vrat	352	49	mannosidase	mannosidase	NN
cord-259237-aty0vrat	352	50	I	-PRON-	PRP
cord-259237-aty0vrat	352	51	ERGIC-53	ERGIC-53	NNP
cord-259237-aty0vrat	352	52	and	and	CC
cord-259237-aty0vrat	352	53	traffic	traffic	NN
cord-259237-aty0vrat	352	54	in	in	IN
cord-259237-aty0vrat	352	55	the	the	DT
cord-259237-aty0vrat	352	56	secretory	secretory	JJ
cord-259237-aty0vrat	352	57	pathway	pathway	NN
cord-259237-aty0vrat	352	58	Endoplasmic	Endoplasmic	NNP
cord-259237-aty0vrat	352	59	reticulum	reticulum	NN
cord-259237-aty0vrat	352	60	(	(	-LRB-
cord-259237-aty0vrat	352	61	ER	ER	NNP
cord-259237-aty0vrat	352	62	)	)	-RRB-
cord-259237-aty0vrat	353	1	mannosidase	mannosidase	NNP
cord-259237-aty0vrat	354	1	I	-PRON-	PRP
cord-259237-aty0vrat	354	2	is	be	VBZ
cord-259237-aty0vrat	354	3	compartmentalized	compartmentalize	VBN
cord-259237-aty0vrat	354	4	and	and	CC
cord-259237-aty0vrat	354	5	required	require	VBN
cord-259237-aty0vrat	354	6	for	for	IN
cord-259237-aty0vrat	354	7	N	n	CD
cord-259237-aty0vrat	354	8	-	-	HYPH
cord-259237-aty0vrat	354	9	glycan	glycan	NN
cord-259237-aty0vrat	354	10	trimming	trimming	NN
cord-259237-aty0vrat	354	11	to	to	IN
cord-259237-aty0vrat	354	12	Man5	Man5	NNP
cord-259237-aty0vrat	354	13	-	-	SYM
cord-259237-aty0vrat	354	14	6GlcNAc2	6glcnac2	CD
cord-259237-aty0vrat	354	15	in	in	IN
cord-259237-aty0vrat	354	16	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	354	17	ER	er	NN
cord-259237-aty0vrat	354	18	-	-	HYPH
cord-259237-aty0vrat	354	19	associated	associate	VBN
cord-259237-aty0vrat	354	20	degradation	degradation	NN
cord-259237-aty0vrat	354	21	Stimulation	stimulation	NN
cord-259237-aty0vrat	354	22	of	of	IN
cord-259237-aty0vrat	354	23	ERAD	ERAD	NNP
cord-259237-aty0vrat	354	24	of	of	IN
cord-259237-aty0vrat	354	25	misfolded	misfolde	VBN
cord-259237-aty0vrat	354	26	null	null	NNP
cord-259237-aty0vrat	354	27	hong	hong	NNP
cord-259237-aty0vrat	354	28	kong	kong	NNP
cord-259237-aty0vrat	355	1	alpha1-antitrypsin	alpha1-antitrypsin	VBN
cord-259237-aty0vrat	355	2	by	by	IN
cord-259237-aty0vrat	355	3	Golgi	Golgi	NNP
cord-259237-aty0vrat	355	4	alpha1,2-mannosidases	alpha1,2-mannosidases	NNP
cord-259237-aty0vrat	355	5	Mannosidase	Mannosidase	NNP
cord-259237-aty0vrat	355	6	IA	IA	NNP
cord-259237-aty0vrat	355	7	is	be	VBZ
cord-259237-aty0vrat	355	8	in	in	IN
cord-259237-aty0vrat	355	9	quality	quality	NN
cord-259237-aty0vrat	355	10	control	control	NN
cord-259237-aty0vrat	355	11	vesicles	vesicle	NNS
cord-259237-aty0vrat	355	12	and	and	CC
cord-259237-aty0vrat	355	13	participates	participate	VBZ
cord-259237-aty0vrat	355	14	in	in	IN
cord-259237-aty0vrat	355	15	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	355	16	targeting	target	VBG
cord-259237-aty0vrat	355	17	to	to	IN
cord-259237-aty0vrat	355	18	ERAD	ERAD	NNP
cord-259237-aty0vrat	355	19	EDEM1	EDEM1	NNP
cord-259237-aty0vrat	356	1	regulates	regulate	VBZ
cord-259237-aty0vrat	356	2	ER	ER	NNP
cord-259237-aty0vrat	356	3	-	-	HYPH
cord-259237-aty0vrat	356	4	associated	associate	VBN
cord-259237-aty0vrat	356	5	degradation	degradation	NN
cord-259237-aty0vrat	356	6	by	by	IN
cord-259237-aty0vrat	356	7	accelerating	accelerate	VBG
cord-259237-aty0vrat	356	8	de	de	NNP
cord-259237-aty0vrat	356	9	-	-	NN
cord-259237-aty0vrat	356	10	mannosylation	mannosylation	NN
cord-259237-aty0vrat	356	11	of	of	IN
cord-259237-aty0vrat	356	12	folding	fold	VBG
cord-259237-aty0vrat	356	13	-	-	HYPH
cord-259237-aty0vrat	356	14	defective	defective	JJ
cord-259237-aty0vrat	356	15	polypeptides	polypeptide	NNS
cord-259237-aty0vrat	356	16	and	and	CC
cord-259237-aty0vrat	356	17	by	by	IN
cord-259237-aty0vrat	356	18	inhibiting	inhibit	VBG
cord-259237-aty0vrat	356	19	their	-PRON-	PRP$
cord-259237-aty0vrat	356	20	covalent	covalent	JJ
cord-259237-aty0vrat	356	21	aggregation	aggregation	NN
cord-259237-aty0vrat	356	22	Glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	356	23	folding	folding	NN
cord-259237-aty0vrat	356	24	and	and	CC
cord-259237-aty0vrat	356	25	the	the	DT
cord-259237-aty0vrat	356	26	role	role	NN
cord-259237-aty0vrat	356	27	of	of	IN
cord-259237-aty0vrat	356	28	EDEM1	edem1	NN
cord-259237-aty0vrat	356	29	,	,	,
cord-259237-aty0vrat	356	30	EDEM2	edem2	NN
cord-259237-aty0vrat	356	31	and	and	CC
cord-259237-aty0vrat	356	32	EDEM3	EDEM3	NNS
cord-259237-aty0vrat	356	33	in	in	IN
cord-259237-aty0vrat	356	34	degradation	degradation	NN
cord-259237-aty0vrat	356	35	of	of	IN
cord-259237-aty0vrat	356	36	folding	folding	NN
cord-259237-aty0vrat	356	37	-	-	HYPH
cord-259237-aty0vrat	356	38	defective	defective	JJ
cord-259237-aty0vrat	356	39	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	357	1	OS-9	OS-9	NNP
cord-259237-aty0vrat	358	1	and	and	CC
cord-259237-aty0vrat	358	2	GRP94	GRP94	NNP
cord-259237-aty0vrat	358	3	deliver	deliver	VB
cord-259237-aty0vrat	358	4	mutant	mutant	JJ
cord-259237-aty0vrat	358	5	alpha1-antitrypsin	alpha1-antitrypsin	NNP
cord-259237-aty0vrat	358	6	to	to	IN
cord-259237-aty0vrat	358	7	the	the	DT
cord-259237-aty0vrat	358	8	Hrd1-SEL1L	hrd1-sel1l	CD
cord-259237-aty0vrat	358	9	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	358	10	ligase	ligase	NN
cord-259237-aty0vrat	358	11	complex	complex	NN
cord-259237-aty0vrat	358	12	for	for	IN
cord-259237-aty0vrat	358	13	ERAD	ERAD	NNP
cord-259237-aty0vrat	359	1	The	the	DT
cord-259237-aty0vrat	359	2	MRH	MRH	NNP
cord-259237-aty0vrat	359	3	domain	domain	NN
cord-259237-aty0vrat	359	4	suggests	suggest	VBZ
cord-259237-aty0vrat	359	5	a	a	DT
cord-259237-aty0vrat	359	6	shared	share	VBN
cord-259237-aty0vrat	359	7	ancestry	ancestry	NN
cord-259237-aty0vrat	359	8	for	for	IN
cord-259237-aty0vrat	359	9	the	the	DT
cord-259237-aty0vrat	359	10	mannose	mannose	NN
cord-259237-aty0vrat	359	11	6-phosphate	6-phosphate	NN
cord-259237-aty0vrat	359	12	receptors	receptor	NNS
cord-259237-aty0vrat	359	13	and	and	CC
cord-259237-aty0vrat	359	14	other	other	JJ
cord-259237-aty0vrat	359	15	N	n	CD
cord-259237-aty0vrat	359	16	-	-	HYPH
cord-259237-aty0vrat	359	17	glycan	glycan	NN
cord-259237-aty0vrat	359	18	-	-	HYPH
cord-259237-aty0vrat	359	19	recognising	recognise	VBG
cord-259237-aty0vrat	359	20	proteins	protein	NNS
cord-259237-aty0vrat	360	1	In	in	IN
cord-259237-aty0vrat	360	2	vitro	vitro	FW
cord-259237-aty0vrat	360	3	analysis	analysis	NN
cord-259237-aty0vrat	360	4	of	of	IN
cord-259237-aty0vrat	360	5	Hrd1p	hrd1p	NN
cord-259237-aty0vrat	360	6	-	-	HYPH
cord-259237-aty0vrat	360	7	mediated	mediate	VBN
cord-259237-aty0vrat	360	8	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	360	9	of	of	IN
cord-259237-aty0vrat	360	10	its	-PRON-	PRP$
cord-259237-aty0vrat	360	11	multispanning	multispanne	VBG
cord-259237-aty0vrat	360	12	membrane	membrane	NN
cord-259237-aty0vrat	360	13	substrate	substrate	NN
cord-259237-aty0vrat	360	14	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-259237-aty0vrat	361	1	(	(	-LRB-
cord-259237-aty0vrat	361	2	HMG)-CoA	hmg)-coa	NN
cord-259237-aty0vrat	361	3	reductase	reductase	NN
cord-259237-aty0vrat	361	4	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	361	5	and	and	CC
cord-259237-aty0vrat	361	6	UBXD8	UBXD8	NNS
cord-259237-aty0vrat	361	7	are	be	VBP
cord-259237-aty0vrat	361	8	engaged	engage	VBN
cord-259237-aty0vrat	361	9	in	in	IN
cord-259237-aty0vrat	361	10	dislocation	dislocation	NN
cord-259237-aty0vrat	361	11	and	and	CC
cord-259237-aty0vrat	361	12	degradation	degradation	NN
cord-259237-aty0vrat	361	13	of	of	IN
cord-259237-aty0vrat	361	14	lipidated	lipidate	VBN
cord-259237-aty0vrat	361	15	ApoB-100	ApoB-100	NNP
cord-259237-aty0vrat	361	16	at	at	IN
cord-259237-aty0vrat	361	17	lipid	lipid	NN
cord-259237-aty0vrat	361	18	droplets	droplet	NNS
cord-259237-aty0vrat	361	19	Structure	Structure	NNP
cord-259237-aty0vrat	361	20	of	of	IN
cord-259237-aty0vrat	361	21	the	the	DT
cord-259237-aty0vrat	361	22	native	native	JJ
cord-259237-aty0vrat	361	23	SEC61	sec61	NN
cord-259237-aty0vrat	361	24	protein	protein	NN
cord-259237-aty0vrat	361	25	-	-	HYPH
cord-259237-aty0vrat	361	26	conducting	conduct	VBG
cord-259237-aty0vrat	361	27	channel	channel	NN
cord-259237-aty0vrat	361	28	Proteasome	Proteasome	NNP
cord-259237-aty0vrat	361	29	19s	19	NNS
cord-259237-aty0vrat	361	30	rp	rp	NNP
cord-259237-aty0vrat	362	1	binding	bind	VBG
cord-259237-aty0vrat	362	2	to	to	IN
cord-259237-aty0vrat	362	3	the	the	DT
cord-259237-aty0vrat	362	4	sec61	sec61	CD
cord-259237-aty0vrat	362	5	channel	channel	NN
cord-259237-aty0vrat	363	1	plays	play	VBZ
cord-259237-aty0vrat	363	2	a	a	DT
cord-259237-aty0vrat	363	3	key	key	JJ
cord-259237-aty0vrat	363	4	role	role	NN
cord-259237-aty0vrat	363	5	in	in	IN
cord-259237-aty0vrat	363	6	erad	erad	NNP
cord-259237-aty0vrat	363	7	A	a	DT
cord-259237-aty0vrat	363	8	membrane	membrane	NN
cord-259237-aty0vrat	363	9	protein	protein	NN
cord-259237-aty0vrat	363	10	required	require	VBN
cord-259237-aty0vrat	363	11	for	for	IN
cord-259237-aty0vrat	363	12	dislocation	dislocation	NN
cord-259237-aty0vrat	363	13	of	of	IN
cord-259237-aty0vrat	363	14	misfolded	misfolded	JJ
cord-259237-aty0vrat	363	15	proteins	protein	NNS
cord-259237-aty0vrat	363	16	from	from	IN
cord-259237-aty0vrat	363	17	the	the	DT
cord-259237-aty0vrat	363	18	ER	ER	NNP
cord-259237-aty0vrat	363	19	A	A	NNP
cord-259237-aty0vrat	363	20	membrane	membrane	NN
cord-259237-aty0vrat	363	21	protein	protein	NN
cord-259237-aty0vrat	363	22	complex	complex	NN
cord-259237-aty0vrat	364	1	mediates	mediate	VBZ
cord-259237-aty0vrat	364	2	retro	retro	JJ
cord-259237-aty0vrat	364	3	-	-	HYPH
cord-259237-aty0vrat	364	4	translocation	translocation	NN
cord-259237-aty0vrat	364	5	from	from	IN
cord-259237-aty0vrat	364	6	the	the	DT
cord-259237-aty0vrat	364	7	ER	ER	NNP
cord-259237-aty0vrat	364	8	lumen	lumen	NN
cord-259237-aty0vrat	364	9	into	into	IN
cord-259237-aty0vrat	364	10	the	the	DT
cord-259237-aty0vrat	364	11	cytosol	cytosol	NN
cord-259237-aty0vrat	364	12	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	365	1	is	be	VBZ
cord-259237-aty0vrat	365	2	a	a	DT
cord-259237-aty0vrat	365	3	rhomboid	rhomboid	JJ
cord-259237-aty0vrat	365	4	pseudoprotease	pseudoprotease	NN
cord-259237-aty0vrat	365	5	required	require	VBN
cord-259237-aty0vrat	365	6	for	for	IN
cord-259237-aty0vrat	365	7	the	the	DT
cord-259237-aty0vrat	365	8	dislocation	dislocation	NN
cord-259237-aty0vrat	365	9	of	of	IN
cord-259237-aty0vrat	365	10	mutant	mutant	JJ
cord-259237-aty0vrat	365	11	alpha-1	alpha-1	NN
cord-259237-aty0vrat	365	12	antitrypsin	antitrypsin	NN
cord-259237-aty0vrat	365	13	from	from	IN
cord-259237-aty0vrat	365	14	the	the	DT
cord-259237-aty0vrat	365	15	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	365	16	reticulum	reticulum	NN
cord-259237-aty0vrat	365	17	Protein	Protein	NNP
cord-259237-aty0vrat	365	18	quality	quality	NN
cord-259237-aty0vrat	365	19	control	control	NN
cord-259237-aty0vrat	365	20	in	in	IN
cord-259237-aty0vrat	365	21	the	the	DT
cord-259237-aty0vrat	365	22	ER	er	NN
cord-259237-aty0vrat	365	23	:	:	:
cord-259237-aty0vrat	365	24	Balancing	balance	VBG
cord-259237-aty0vrat	365	25	the	the	DT
cord-259237-aty0vrat	365	26	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	365	27	checkbook	checkbook	NN
cord-259237-aty0vrat	366	1	The	the	DT
cord-259237-aty0vrat	366	2	ubiquitylation	ubiquitylation	NN
cord-259237-aty0vrat	366	3	machinery	machinery	NN
cord-259237-aty0vrat	366	4	of	of	IN
cord-259237-aty0vrat	366	5	the	the	DT
cord-259237-aty0vrat	366	6	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	366	7	reticulum	reticulum	NN
cord-259237-aty0vrat	366	8	Role	role	NN
cord-259237-aty0vrat	366	9	of	of	IN
cord-259237-aty0vrat	366	10	26S	26S	NNP
cord-259237-aty0vrat	366	11	proteasome	proteasome	NN
cord-259237-aty0vrat	366	12	and	and	CC
cord-259237-aty0vrat	366	13	HRD	HRD	NNP
cord-259237-aty0vrat	366	14	genes	gene	NNS
cord-259237-aty0vrat	366	15	in	in	IN
cord-259237-aty0vrat	366	16	the	the	DT
cord-259237-aty0vrat	366	17	degradation	degradation	NN
cord-259237-aty0vrat	366	18	of	of	IN
cord-259237-aty0vrat	366	19	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-259237-aty0vrat	366	20	-	-	HYPH
cord-259237-aty0vrat	366	21	CoA	coa	NN
cord-259237-aty0vrat	366	22	reductase	reductase	NN
cord-259237-aty0vrat	366	23	,	,	,
cord-259237-aty0vrat	366	24	an	an	DT
cord-259237-aty0vrat	366	25	integral	integral	JJ
cord-259237-aty0vrat	366	26	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	366	27	reticulum	reticulum	NN
cord-259237-aty0vrat	366	28	membrane	membrane	NN
cord-259237-aty0vrat	366	29	protein	protein	NN
cord-259237-aty0vrat	366	30	Autoubiquitination	Autoubiquitination	NNP
cord-259237-aty0vrat	366	31	of	of	IN
cord-259237-aty0vrat	366	32	the	the	DT
cord-259237-aty0vrat	366	33	HRD1	HRD1	NNP
cord-259237-aty0vrat	366	34	ligase	ligase	NN
cord-259237-aty0vrat	366	35	triggers	trigger	VBZ
cord-259237-aty0vrat	366	36	protein	protein	NN
cord-259237-aty0vrat	366	37	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	366	38	in	in	IN
cord-259237-aty0vrat	366	39	ERAD	ERAD	NNP
cord-259237-aty0vrat	366	40	Key	key	JJ
cord-259237-aty0vrat	366	41	steps	step	NNS
cord-259237-aty0vrat	366	42	in	in	IN
cord-259237-aty0vrat	366	43	ERAD	ERAD	NNP
cord-259237-aty0vrat	366	44	of	of	IN
cord-259237-aty0vrat	366	45	luminal	luminal	JJ
cord-259237-aty0vrat	366	46	ER	er	NN
cord-259237-aty0vrat	366	47	proteins	protein	NNS
cord-259237-aty0vrat	366	48	reconstituted	reconstitute	VBN
cord-259237-aty0vrat	366	49	with	with	IN
cord-259237-aty0vrat	366	50	purified	purify	VBN
cord-259237-aty0vrat	366	51	components	component	NNS
cord-259237-aty0vrat	366	52	Selective	selective	JJ
cord-259237-aty0vrat	366	53	ubiquitylation	ubiquitylation	NN
cord-259237-aty0vrat	366	54	of	of	IN
cord-259237-aty0vrat	366	55	p21	p21	NN
cord-259237-aty0vrat	366	56	and	and	CC
cord-259237-aty0vrat	366	57	Cdt1	Cdt1	NNP
cord-259237-aty0vrat	366	58	by	by	IN
cord-259237-aty0vrat	366	59	UBCH8	ubch8	NN
cord-259237-aty0vrat	366	60	and	and	CC
cord-259237-aty0vrat	366	61	UBE2	UBE2	NNP
cord-259237-aty0vrat	367	1	G	g	NN
cord-259237-aty0vrat	367	2	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	367	3	-	-	HYPH
cord-259237-aty0vrat	367	4	conjugating	conjugate	VBG
cord-259237-aty0vrat	367	5	enzymes	enzyme	NNS
cord-259237-aty0vrat	367	6	via	via	IN
cord-259237-aty0vrat	367	7	the	the	DT
cord-259237-aty0vrat	367	8	CRL4Cdt2	crl4cdt2	NN
cord-259237-aty0vrat	367	9	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	367	10	ligase	ligase	NN
cord-259237-aty0vrat	367	11	complex	complex	JJ
cord-259237-aty0vrat	367	12	Endoplasmic	Endoplasmic	NNP
cord-259237-aty0vrat	367	13	reticulum	reticulum	NN
cord-259237-aty0vrat	367	14	degradation	degradation	NN
cord-259237-aty0vrat	367	15	requires	require	VBZ
cord-259237-aty0vrat	367	16	lumen	lumen	NN
cord-259237-aty0vrat	367	17	to	to	IN
cord-259237-aty0vrat	367	18	cytosol	cytosol	NN
cord-259237-aty0vrat	367	19	signaling	signaling	NN
cord-259237-aty0vrat	367	20	.	.	.
cord-259237-aty0vrat	368	1	Transmembrane	Transmembrane	NNP
cord-259237-aty0vrat	368	2	control	control	NN
cord-259237-aty0vrat	368	3	of	of	IN
cord-259237-aty0vrat	368	4	HRD1P	HRD1P	NNS
cord-259237-aty0vrat	368	5	by	by	IN
cord-259237-aty0vrat	368	6	HRD3P	HRD3P	NNP
cord-259237-aty0vrat	368	7	Association	Association	NNP
cord-259237-aty0vrat	368	8	of	of	IN
cord-259237-aty0vrat	368	9	the	the	DT
cord-259237-aty0vrat	368	10	SEL1L	sel1l	JJ
cord-259237-aty0vrat	368	11	protein	protein	NN
cord-259237-aty0vrat	368	12	transmembrane	transmembrane	NN
cord-259237-aty0vrat	368	13	domain	domain	NN
cord-259237-aty0vrat	368	14	with	with	IN
cord-259237-aty0vrat	368	15	HRD1	HRD1	NNP
cord-259237-aty0vrat	368	16	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	368	17	ligase	ligase	NN
cord-259237-aty0vrat	368	18	regulates	regulate	VBZ
cord-259237-aty0vrat	368	19	ERAD	ERAD	NNP
cord-259237-aty0vrat	368	20	-	-	HYPH
cord-259237-aty0vrat	368	21	L	L	NNP
cord-259237-aty0vrat	368	22	Usa1	Usa1	NNP
cord-259237-aty0vrat	368	23	functions	function	NNS
cord-259237-aty0vrat	368	24	as	as	IN
cord-259237-aty0vrat	368	25	a	a	DT
cord-259237-aty0vrat	368	26	scaffold	scaffold	NN
cord-259237-aty0vrat	368	27	of	of	IN
cord-259237-aty0vrat	368	28	the	the	DT
cord-259237-aty0vrat	368	29	HRD	HRD	NNP
cord-259237-aty0vrat	368	30	-	-	HYPH
cord-259237-aty0vrat	368	31	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	368	32	ligase	ligase	NN
cord-259237-aty0vrat	369	1	The	the	DT
cord-259237-aty0vrat	369	2	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	369	3	-	-	HYPH
cord-259237-aty0vrat	369	4	domain	domain	NN
cord-259237-aty0vrat	369	5	protein	protein	NN
cord-259237-aty0vrat	369	6	HERP	HERP	NNP
cord-259237-aty0vrat	369	7	forms	form	VBZ
cord-259237-aty0vrat	369	8	a	a	DT
cord-259237-aty0vrat	369	9	complex	complex	NN
cord-259237-aty0vrat	369	10	with	with	IN
cord-259237-aty0vrat	369	11	components	component	NNS
cord-259237-aty0vrat	369	12	of	of	IN
cord-259237-aty0vrat	369	13	the	the	DT
cord-259237-aty0vrat	369	14	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	369	15	reticulum	reticulum	NN
cord-259237-aty0vrat	369	16	associated	associate	VBD
cord-259237-aty0vrat	369	17	degradation	degradation	NN
cord-259237-aty0vrat	369	18	pathway	pathway	NN
cord-259237-aty0vrat	369	19	Membrane	membrane	NN
cord-259237-aty0vrat	369	20	topology	topology	NN
cord-259237-aty0vrat	369	21	of	of	IN
cord-259237-aty0vrat	369	22	the	the	DT
cord-259237-aty0vrat	369	23	yeast	yeast	NN
cord-259237-aty0vrat	369	24	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	369	25	reticulum	reticulum	NN
cord-259237-aty0vrat	369	26	-	-	HYPH
cord-259237-aty0vrat	369	27	localized	localize	VBN
cord-259237-aty0vrat	369	28	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	369	29	ligase	ligase	NN
cord-259237-aty0vrat	369	30	Doa10	Doa10	NNP
cord-259237-aty0vrat	369	31	and	and	CC
cord-259237-aty0vrat	369	32	comparison	comparison	NN
cord-259237-aty0vrat	369	33	with	with	IN
cord-259237-aty0vrat	369	34	its	-PRON-	PRP$
cord-259237-aty0vrat	369	35	human	human	JJ
cord-259237-aty0vrat	369	36	ortholog	ortholog	NN
cord-259237-aty0vrat	369	37	TEB4	TEB4	NNP
cord-259237-aty0vrat	369	38	(	(	-LRB-
cord-259237-aty0vrat	369	39	MARCH	MARCH	NNP
cord-259237-aty0vrat	369	40	-	-	HYPH
cord-259237-aty0vrat	369	41	IV	IV	NNP
cord-259237-aty0vrat	369	42	)	)	-RRB-
cord-259237-aty0vrat	370	1	Ube2j2	Ube2j2	NNP
cord-259237-aty0vrat	370	2	ubiquitinates	ubiquitinates	NNP
cord-259237-aty0vrat	371	1	hydroxylated	hydroxylated	JJ
cord-259237-aty0vrat	371	2	amino	amino	NN
cord-259237-aty0vrat	371	3	acids	acid	NNS
cord-259237-aty0vrat	371	4	on	on	IN
cord-259237-aty0vrat	371	5	ER	ER	NNP
cord-259237-aty0vrat	371	6	-	-	HYPH
cord-259237-aty0vrat	371	7	associated	associate	VBN
cord-259237-aty0vrat	371	8	degradation	degradation	NN
cord-259237-aty0vrat	371	9	substrates	substrate	VBZ
cord-259237-aty0vrat	371	10	HRD1	HRD1	NNPS
cord-259237-aty0vrat	371	11	and	and	CC
cord-259237-aty0vrat	371	12	UBE2J1	UBE2J1	NNP
cord-259237-aty0vrat	371	13	target	target	NN
cord-259237-aty0vrat	371	14	misfolded	misfolde	VBN
cord-259237-aty0vrat	371	15	MHC	MHC	NNP
cord-259237-aty0vrat	371	16	class	class	NN
cord-259237-aty0vrat	372	1	I	-PRON-	PRP
cord-259237-aty0vrat	372	2	heavy	heavy	JJ
cord-259237-aty0vrat	372	3	chains	chain	NNS
cord-259237-aty0vrat	372	4	for	for	IN
cord-259237-aty0vrat	372	5	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	372	6	reticulum	reticulum	NN
cord-259237-aty0vrat	372	7	-	-	HYPH
cord-259237-aty0vrat	372	8	associated	associate	VBN
cord-259237-aty0vrat	372	9	degradation	degradation	NN
cord-259237-aty0vrat	373	1	Distinct	distinct	JJ
cord-259237-aty0vrat	373	2	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	373	3	-	-	HYPH
cord-259237-aty0vrat	373	4	ligase	ligase	NN
cord-259237-aty0vrat	373	5	complexes	complex	NNS
cord-259237-aty0vrat	373	6	define	define	VB
cord-259237-aty0vrat	373	7	convergent	convergent	JJ
cord-259237-aty0vrat	373	8	pathways	pathway	NNS
cord-259237-aty0vrat	373	9	for	for	IN
cord-259237-aty0vrat	373	10	the	the	DT
cord-259237-aty0vrat	373	11	degradation	degradation	NN
cord-259237-aty0vrat	373	12	of	of	IN
cord-259237-aty0vrat	373	13	ER	ER	NNP
cord-259237-aty0vrat	373	14	proteins	protein	NNS
cord-259237-aty0vrat	374	1	The	the	DT
cord-259237-aty0vrat	374	2	yeast	yeast	NN
cord-259237-aty0vrat	374	3	ERAD	ERAD	NNP
cord-259237-aty0vrat	374	4	-	-	HYPH
cord-259237-aty0vrat	374	5	C	C	NNP
cord-259237-aty0vrat	374	6	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	374	7	ligase	ligase	NN
cord-259237-aty0vrat	374	8	Doa10	Doa10	NNP
cord-259237-aty0vrat	374	9	recognizes	recognize	VBZ
cord-259237-aty0vrat	374	10	an	an	DT
cord-259237-aty0vrat	374	11	intramembrane	intramembrane	NN
cord-259237-aty0vrat	374	12	degron	degron	NNP
cord-259237-aty0vrat	374	13	Htm1p	Htm1p	NNP
cord-259237-aty0vrat	374	14	,	,	,
cord-259237-aty0vrat	374	15	a	a	DT
cord-259237-aty0vrat	374	16	mannosidase	mannosidase	NN
cord-259237-aty0vrat	374	17	-	-	HYPH
cord-259237-aty0vrat	374	18	like	like	JJ
cord-259237-aty0vrat	374	19	protein	protein	NN
cord-259237-aty0vrat	374	20	,	,	,
cord-259237-aty0vrat	374	21	is	be	VBZ
cord-259237-aty0vrat	374	22	involved	involve	VBN
cord-259237-aty0vrat	374	23	in	in	IN
cord-259237-aty0vrat	374	24	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	374	25	degradation	degradation	NN
cord-259237-aty0vrat	374	26	in	in	IN
cord-259237-aty0vrat	374	27	yeast	yeast	NN
cord-259237-aty0vrat	375	1	The	the	DT
cord-259237-aty0vrat	375	2	saccharomyces	saccharomyce	NNS
cord-259237-aty0vrat	375	3	cerevisiae	cerevisiae	VBZ
cord-259237-aty0vrat	375	4	processing	process	VBG
cord-259237-aty0vrat	375	5	alpha	alpha	NN
cord-259237-aty0vrat	375	6	1,2-mannosidase	1,2-mannosidase	NNP
cord-259237-aty0vrat	375	7	is	be	VBZ
cord-259237-aty0vrat	375	8	localized	localize	VBN
cord-259237-aty0vrat	375	9	in	in	IN
cord-259237-aty0vrat	375	10	the	the	DT
cord-259237-aty0vrat	375	11	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	375	12	reticulum	reticulum	NN
cord-259237-aty0vrat	375	13	,	,	,
cord-259237-aty0vrat	375	14	independently	independently	RB
cord-259237-aty0vrat	375	15	of	of	IN
cord-259237-aty0vrat	375	16	known	know	VBN
cord-259237-aty0vrat	375	17	retrieval	retrieval	NN
cord-259237-aty0vrat	375	18	motifs	motif	NNS
cord-259237-aty0vrat	375	19	Segregation	segregation	NN
cord-259237-aty0vrat	375	20	and	and	CC
cord-259237-aty0vrat	375	21	rapid	rapid	JJ
cord-259237-aty0vrat	375	22	turnover	turnover	NN
cord-259237-aty0vrat	375	23	of	of	IN
cord-259237-aty0vrat	375	24	EDEM1	edem1	NN
cord-259237-aty0vrat	375	25	by	by	IN
cord-259237-aty0vrat	375	26	an	an	DT
cord-259237-aty0vrat	375	27	autophagy	autophagy	NN
cord-259237-aty0vrat	375	28	-	-	HYPH
cord-259237-aty0vrat	375	29	like	like	JJ
cord-259237-aty0vrat	375	30	mechanism	mechanism	NN
cord-259237-aty0vrat	375	31	modulates	modulate	VBZ
cord-259237-aty0vrat	375	32	standard	standard	JJ
cord-259237-aty0vrat	375	33	ERAD	ERAD	NNP
cord-259237-aty0vrat	375	34	and	and	CC
cord-259237-aty0vrat	375	35	folding	folding	NN
cord-259237-aty0vrat	375	36	activities	activity	NNS
cord-259237-aty0vrat	375	37	Human	human	JJ
cord-259237-aty0vrat	375	38	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	375	39	reticulum	reticulum	NN
cord-259237-aty0vrat	375	40	mannosidase	mannosidase	NN
cord-259237-aty0vrat	376	1	I	-PRON-	PRP
cord-259237-aty0vrat	376	2	is	be	VBZ
cord-259237-aty0vrat	376	3	subject	subject	JJ
cord-259237-aty0vrat	376	4	to	to	IN
cord-259237-aty0vrat	376	5	regulated	regulated	JJ
cord-259237-aty0vrat	376	6	proteolysis	proteolysis	NN
cord-259237-aty0vrat	376	7	Disposal	disposal	NN
cord-259237-aty0vrat	376	8	of	of	IN
cord-259237-aty0vrat	376	9	cargo	cargo	NN
cord-259237-aty0vrat	376	10	and	and	CC
cord-259237-aty0vrat	376	11	of	of	IN
cord-259237-aty0vrat	376	12	ERAD	ERAD	NNP
cord-259237-aty0vrat	376	13	regulators	regulator	NNS
cord-259237-aty0vrat	376	14	from	from	IN
cord-259237-aty0vrat	376	15	the	the	DT
cord-259237-aty0vrat	376	16	mammalian	mammalian	JJ
cord-259237-aty0vrat	376	17	ER	ER	NNP
cord-259237-aty0vrat	376	18	Two	two	CD
cord-259237-aty0vrat	376	19	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	376	20	reticulum	reticulum	NN
cord-259237-aty0vrat	376	21	-	-	HYPH
cord-259237-aty0vrat	376	22	associated	associate	VBN
cord-259237-aty0vrat	376	23	degradation	degradation	NN
cord-259237-aty0vrat	376	24	(	(	-LRB-
cord-259237-aty0vrat	376	25	ERAD	ERAD	NNP
cord-259237-aty0vrat	376	26	)	)	-RRB-
cord-259237-aty0vrat	376	27	systems	system	NNS
cord-259237-aty0vrat	376	28	for	for	IN
cord-259237-aty0vrat	376	29	the	the	DT
cord-259237-aty0vrat	376	30	novel	novel	JJ
cord-259237-aty0vrat	376	31	variant	variant	NN
cord-259237-aty0vrat	376	32	of	of	IN
cord-259237-aty0vrat	376	33	the	the	DT
cord-259237-aty0vrat	376	34	mutant	mutant	JJ
cord-259237-aty0vrat	376	35	dysferlin	dysferlin	NN
cord-259237-aty0vrat	376	36	:	:	:
cord-259237-aty0vrat	377	1	Ubiquitin	Ubiquitin	NNP
cord-259237-aty0vrat	377	2	/	/	SYM
cord-259237-aty0vrat	377	3	proteasome	proteasome	NN
cord-259237-aty0vrat	377	4	ERAD(i	erad(i	NN
cord-259237-aty0vrat	377	5	)	)	-RRB-
cord-259237-aty0vrat	378	1	and	and	CC
cord-259237-aty0vrat	378	2	autophagy	autophagy	NN
cord-259237-aty0vrat	378	3	/	/	SYM
cord-259237-aty0vrat	378	4	lysosome	lysosome	NN
cord-259237-aty0vrat	378	5	ERAD(ii	erad(ii	NN
cord-259237-aty0vrat	378	6	)	)	-RRB-
cord-259237-aty0vrat	379	1	A	a	DT
cord-259237-aty0vrat	379	2	novel	novel	JJ
cord-259237-aty0vrat	379	3	ER	ER	NNP
cord-259237-aty0vrat	379	4	alpha	alpha	NN
cord-259237-aty0vrat	379	5	-	-	HYPH
cord-259237-aty0vrat	379	6	mannosidase	mannosidase	NN
cord-259237-aty0vrat	379	7	-	-	HYPH
cord-259237-aty0vrat	379	8	like	like	JJ
cord-259237-aty0vrat	379	9	protein	protein	NN
cord-259237-aty0vrat	379	10	accelerates	accelerate	VBZ
cord-259237-aty0vrat	379	11	ER	ER	NNP
cord-259237-aty0vrat	379	12	-	-	HYPH
cord-259237-aty0vrat	379	13	associated	associate	VBN
cord-259237-aty0vrat	379	14	degradation	degradation	NN
cord-259237-aty0vrat	380	1	A	a	DT
cord-259237-aty0vrat	380	2	novel	novel	JJ
cord-259237-aty0vrat	380	3	stress	stress	NN
cord-259237-aty0vrat	380	4	-	-	HYPH
cord-259237-aty0vrat	380	5	induced	induce	VBN
cord-259237-aty0vrat	380	6	EDEM	EDEM	NNP
cord-259237-aty0vrat	380	7	variant	variant	NN
cord-259237-aty0vrat	380	8	regulating	regulate	VBG
cord-259237-aty0vrat	380	9	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	380	10	reticulum	reticulum	NN
cord-259237-aty0vrat	380	11	-	-	HYPH
cord-259237-aty0vrat	380	12	associated	associate	VBN
cord-259237-aty0vrat	380	13	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	380	14	degradation	degradation	NN
cord-259237-aty0vrat	380	15	Glycan	glycan	JJ
cord-259237-aty0vrat	380	16	regulation	regulation	NN
cord-259237-aty0vrat	380	17	of	of	IN
cord-259237-aty0vrat	380	18	ER	er	NN
cord-259237-aty0vrat	380	19	-	-	HYPH
cord-259237-aty0vrat	380	20	associated	associate	VBN
cord-259237-aty0vrat	380	21	degradation	degradation	NN
cord-259237-aty0vrat	380	22	through	through	IN
cord-259237-aty0vrat	380	23	compartmentalization	compartmentalization	NN
cord-259237-aty0vrat	380	24	The	the	DT
cord-259237-aty0vrat	380	25	mammalian	mammalian	JJ
cord-259237-aty0vrat	380	26	UPR	UPR	NNP
cord-259237-aty0vrat	380	27	boosts	boost	VBZ
cord-259237-aty0vrat	380	28	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	380	29	ERAD	ERAD	NNP
cord-259237-aty0vrat	380	30	by	by	IN
cord-259237-aty0vrat	380	31	suppressing	suppress	VBG
cord-259237-aty0vrat	380	32	the	the	DT
cord-259237-aty0vrat	380	33	proteolytic	proteolytic	JJ
cord-259237-aty0vrat	380	34	downregulation	downregulation	NN
cord-259237-aty0vrat	380	35	of	of	IN
cord-259237-aty0vrat	380	36	er	er	UH
cord-259237-aty0vrat	380	37	mannosidase	mannosidase	NN
cord-259237-aty0vrat	381	1	i	i	PRP
cord-259237-aty0vrat	382	1	How	how	WRB
cord-259237-aty0vrat	382	2	viruses	virus	NNS
cord-259237-aty0vrat	382	3	use	use	VBP
cord-259237-aty0vrat	382	4	the	the	DT
cord-259237-aty0vrat	382	5	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	382	6	reticulum	reticulum	NN
cord-259237-aty0vrat	382	7	for	for	IN
cord-259237-aty0vrat	382	8	entry	entry	NN
cord-259237-aty0vrat	382	9	,	,	,
cord-259237-aty0vrat	382	10	replication	replication	NN
cord-259237-aty0vrat	382	11	,	,	,
cord-259237-aty0vrat	382	12	and	and	CC
cord-259237-aty0vrat	382	13	assembly	assembly	NN
cord-259237-aty0vrat	383	1	The	the	DT
cord-259237-aty0vrat	383	2	expanding	expand	VBG
cord-259237-aty0vrat	383	3	roles	role	NNS
cord-259237-aty0vrat	383	4	of	of	IN
cord-259237-aty0vrat	383	5	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	383	6	reticulum	reticulum	NN
cord-259237-aty0vrat	383	7	stress	stress	NN
cord-259237-aty0vrat	383	8	in	in	IN
cord-259237-aty0vrat	383	9	virus	virus	NN
cord-259237-aty0vrat	383	10	replication	replication	NN
cord-259237-aty0vrat	383	11	and	and	CC
cord-259237-aty0vrat	383	12	pathogenesis	pathogenesis	NN
cord-259237-aty0vrat	383	13	Unfolded	unfold	VBD
cord-259237-aty0vrat	383	14	protein	protein	NN
cord-259237-aty0vrat	383	15	response	response	NN
cord-259237-aty0vrat	383	16	in	in	IN
cord-259237-aty0vrat	383	17	hepatitis	hepatitis	NNP
cord-259237-aty0vrat	383	18	c	c	NNP
cord-259237-aty0vrat	383	19	virus	virus	NN
cord-259237-aty0vrat	383	20	infection	infection	NN
cord-259237-aty0vrat	383	21	Modulation	modulation	NN
cord-259237-aty0vrat	383	22	of	of	IN
cord-259237-aty0vrat	383	23	the	the	DT
cord-259237-aty0vrat	383	24	unfolded	unfolded	JJ
cord-259237-aty0vrat	383	25	protein	protein	NN
cord-259237-aty0vrat	383	26	response	response	NN
cord-259237-aty0vrat	383	27	by	by	IN
cord-259237-aty0vrat	383	28	the	the	DT
cord-259237-aty0vrat	383	29	human	human	JJ
cord-259237-aty0vrat	383	30	hepatitis	hepatitis	NN
cord-259237-aty0vrat	383	31	B	B	NNP
cord-259237-aty0vrat	383	32	virus	virus	NN
cord-259237-aty0vrat	383	33	Coronavirus	Coronavirus	NNP
cord-259237-aty0vrat	383	34	infection	infection	NN
cord-259237-aty0vrat	383	35	,	,	,
cord-259237-aty0vrat	383	36	ER	ER	NNP
cord-259237-aty0vrat	383	37	stress	stress	NN
cord-259237-aty0vrat	383	38	,	,	,
cord-259237-aty0vrat	383	39	apoptosis	apoptosis	NN
cord-259237-aty0vrat	383	40	and	and	CC
cord-259237-aty0vrat	383	41	innate	innate	JJ
cord-259237-aty0vrat	383	42	immunity	immunity	NN
cord-259237-aty0vrat	383	43	Differential	differential	NN
cord-259237-aty0vrat	383	44	unfolded	unfold	VBN
cord-259237-aty0vrat	383	45	protein	protein	NN
cord-259237-aty0vrat	383	46	response	response	NN
cord-259237-aty0vrat	383	47	during	during	IN
cord-259237-aty0vrat	383	48	chikungunya	chikungunya	NN
cord-259237-aty0vrat	383	49	and	and	CC
cord-259237-aty0vrat	383	50	sindbis	sindbis	NN
cord-259237-aty0vrat	383	51	virus	virus	NN
cord-259237-aty0vrat	383	52	infection	infection	NN
cord-259237-aty0vrat	383	53	:	:	:
cord-259237-aty0vrat	383	54	Chikv	Chikv	NNP
cord-259237-aty0vrat	383	55	nsp4	nsp4	NNP
cord-259237-aty0vrat	383	56	suppresses	suppress	VBZ
cord-259237-aty0vrat	383	57	eif2alpha	eif2alpha	NNP
cord-259237-aty0vrat	383	58	phosphorylation	phosphorylation	JJ
cord-259237-aty0vrat	383	59	HIV	HIV	NNP
cord-259237-aty0vrat	383	60	infection	infection	NN
cord-259237-aty0vrat	383	61	and	and	CC
cord-259237-aty0vrat	383	62	antiretroviral	antiretroviral	JJ
cord-259237-aty0vrat	383	63	therapy	therapy	NN
cord-259237-aty0vrat	383	64	lead	lead	VBP
cord-259237-aty0vrat	383	65	to	to	IN
cord-259237-aty0vrat	383	66	unfolded	unfold	VBN
cord-259237-aty0vrat	383	67	protein	protein	NN
cord-259237-aty0vrat	383	68	response	response	NN
cord-259237-aty0vrat	383	69	activation	activation	NN
cord-259237-aty0vrat	383	70	Signal	Signal	NNP
cord-259237-aty0vrat	383	71	integration	integration	NN
cord-259237-aty0vrat	383	72	via	via	IN
cord-259237-aty0vrat	383	73	PKR	PKR	NNP
cord-259237-aty0vrat	384	1	The	the	DT
cord-259237-aty0vrat	384	2	pathway	pathway	NN
cord-259237-aty0vrat	384	3	of	of	IN
cord-259237-aty0vrat	384	4	hcv	hcv	NNP
cord-259237-aty0vrat	384	5	ires	ires	NNP
cord-259237-aty0vrat	384	6	-	-	HYPH
cord-259237-aty0vrat	384	7	mediated	mediate	VBN
cord-259237-aty0vrat	384	8	translation	translation	NN
cord-259237-aty0vrat	384	9	initiation	initiation	NN
cord-259237-aty0vrat	385	1	The	the	DT
cord-259237-aty0vrat	385	2	LMP1	LMP1	NNP
cord-259237-aty0vrat	385	3	oncogene	oncogene	NN
cord-259237-aty0vrat	385	4	of	of	IN
cord-259237-aty0vrat	385	5	EBV	EBV	NNP
cord-259237-aty0vrat	385	6	activates	activate	VBZ
cord-259237-aty0vrat	385	7	PERK	perk	NN
cord-259237-aty0vrat	385	8	and	and	CC
cord-259237-aty0vrat	385	9	the	the	DT
cord-259237-aty0vrat	385	10	unfolded	unfolded	JJ
cord-259237-aty0vrat	385	11	protein	protein	NN
cord-259237-aty0vrat	385	12	response	response	NN
cord-259237-aty0vrat	385	13	to	to	TO
cord-259237-aty0vrat	385	14	drive	drive	VB
cord-259237-aty0vrat	385	15	its	-PRON-	PRP$
cord-259237-aty0vrat	385	16	own	own	JJ
cord-259237-aty0vrat	385	17	synthesis	synthesis	NN
cord-259237-aty0vrat	385	18	Herpes	Herpes	NNP
cord-259237-aty0vrat	385	19	simplex	simplex	NN
cord-259237-aty0vrat	385	20	virus	virus	NN
cord-259237-aty0vrat	385	21	1	1	CD
cord-259237-aty0vrat	385	22	infection	infection	NN
cord-259237-aty0vrat	385	23	activates	activate	VBZ
cord-259237-aty0vrat	385	24	the	the	DT
cord-259237-aty0vrat	385	25	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	385	26	reticulum	reticulum	NN
cord-259237-aty0vrat	385	27	resident	resident	NN
cord-259237-aty0vrat	385	28	kinase	kinase	VBZ
cord-259237-aty0vrat	385	29	PERL	PERL	NNP
cord-259237-aty0vrat	385	30	and	and	CC
cord-259237-aty0vrat	385	31	mediates	mediate	VBZ
cord-259237-aty0vrat	385	32	eIF-2alpha	eif-2alpha	JJ
cord-259237-aty0vrat	385	33	dephosphorylation	dephosphorylation	NN
cord-259237-aty0vrat	385	34	by	by	IN
cord-259237-aty0vrat	385	35	the	the	DT
cord-259237-aty0vrat	385	36	gamma(1)34.5	gamma(1)34.5	NNP
cord-259237-aty0vrat	385	37	protein	protein	NN
cord-259237-aty0vrat	386	1	The	the	DT
cord-259237-aty0vrat	386	2	african	african	JJ
cord-259237-aty0vrat	386	3	swine	swine	NN
cord-259237-aty0vrat	386	4	fever	fever	NN
cord-259237-aty0vrat	386	5	virus	virus	NN
cord-259237-aty0vrat	386	6	DP71L	DP71L	NNP
cord-259237-aty0vrat	387	1	protein	protein	NN
cord-259237-aty0vrat	387	2	recruits	recruit	VBZ
cord-259237-aty0vrat	387	3	the	the	DT
cord-259237-aty0vrat	387	4	protein	protein	NN
cord-259237-aty0vrat	387	5	phosphatase	phosphatase	NN
cord-259237-aty0vrat	387	6	1	1	CD
cord-259237-aty0vrat	387	7	catalytic	catalytic	JJ
cord-259237-aty0vrat	387	8	subunit	subunit	NN
cord-259237-aty0vrat	387	9	to	to	TO
cord-259237-aty0vrat	387	10	dephosphorylate	dephosphorylate	VB
cord-259237-aty0vrat	387	11	eIF2alpha	eif2alpha	NN
cord-259237-aty0vrat	387	12	and	and	CC
cord-259237-aty0vrat	387	13	inhibits	inhibit	VBZ
cord-259237-aty0vrat	387	14	CHOP	chop	NN
cord-259237-aty0vrat	387	15	induction	induction	NN
cord-259237-aty0vrat	387	16	but	but	CC
cord-259237-aty0vrat	387	17	is	be	VBZ
cord-259237-aty0vrat	387	18	dispensable	dispensable	JJ
cord-259237-aty0vrat	387	19	for	for	IN
cord-259237-aty0vrat	387	20	these	these	DT
cord-259237-aty0vrat	387	21	activities	activity	NNS
cord-259237-aty0vrat	387	22	during	during	IN
cord-259237-aty0vrat	387	23	virus	virus	NN
cord-259237-aty0vrat	387	24	infection	infection	NN
cord-259237-aty0vrat	387	25	Protein	Protein	NNP
cord-259237-aty0vrat	387	26	synthesis	synthesis	NN
cord-259237-aty0vrat	387	27	and	and	CC
cord-259237-aty0vrat	387	28	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	387	29	reticulum	reticulum	NN
cord-259237-aty0vrat	387	30	stress	stress	NN
cord-259237-aty0vrat	387	31	can	can	MD
cord-259237-aty0vrat	387	32	be	be	VB
cord-259237-aty0vrat	387	33	modulated	modulate	VBN
cord-259237-aty0vrat	387	34	by	by	IN
cord-259237-aty0vrat	387	35	the	the	DT
cord-259237-aty0vrat	387	36	hepatitis	hepatitis	NN
cord-259237-aty0vrat	387	37	C	C	NNP
cord-259237-aty0vrat	387	38	virus	virus	NN
cord-259237-aty0vrat	387	39	envelope	envelope	NN
cord-259237-aty0vrat	387	40	protein	protein	NN
cord-259237-aty0vrat	387	41	E2	E2	NNP
cord-259237-aty0vrat	387	42	through	through	IN
cord-259237-aty0vrat	387	43	the	the	DT
cord-259237-aty0vrat	387	44	eukaryotic	eukaryotic	JJ
cord-259237-aty0vrat	387	45	initiation	initiation	NN
cord-259237-aty0vrat	387	46	factor	factor	NN
cord-259237-aty0vrat	387	47	2alpha	2alpha	CD
cord-259237-aty0vrat	387	48	kinase	kinase	NN
cord-259237-aty0vrat	387	49	PERK	perk	NN
cord-259237-aty0vrat	388	1	Influenza	Influenza	NNP
cord-259237-aty0vrat	388	2	a	a	DT
cord-259237-aty0vrat	388	3	viral	viral	JJ
cord-259237-aty0vrat	388	4	replication	replication	NN
cord-259237-aty0vrat	388	5	is	be	VBZ
cord-259237-aty0vrat	388	6	blocked	block	VBN
cord-259237-aty0vrat	388	7	by	by	IN
cord-259237-aty0vrat	388	8	inhibition	inhibition	NN
cord-259237-aty0vrat	388	9	of	of	IN
cord-259237-aty0vrat	388	10	the	the	DT
cord-259237-aty0vrat	388	11	inositol	inositol	NN
cord-259237-aty0vrat	388	12	-	-	HYPH
cord-259237-aty0vrat	388	13	requiring	require	VBG
cord-259237-aty0vrat	388	14	enzyme	enzyme	NN
cord-259237-aty0vrat	388	15	1	1	CD
cord-259237-aty0vrat	388	16	(	(	-LRB-
cord-259237-aty0vrat	388	17	IER1	IER1	NNP
cord-259237-aty0vrat	388	18	)	)	-RRB-
cord-259237-aty0vrat	388	19	stress	stress	NN
cord-259237-aty0vrat	388	20	pathway	pathway	NN
cord-259237-aty0vrat	388	21	The	the	DT
cord-259237-aty0vrat	388	22	ATF6	ATF6	NNP
cord-259237-aty0vrat	388	23	branch	branch	NN
cord-259237-aty0vrat	388	24	of	of	IN
cord-259237-aty0vrat	388	25	unfolded	unfolded	JJ
cord-259237-aty0vrat	388	26	protein	protein	NN
cord-259237-aty0vrat	388	27	response	response	NN
cord-259237-aty0vrat	388	28	and	and	CC
cord-259237-aty0vrat	388	29	apoptosis	apoptosis	NN
cord-259237-aty0vrat	388	30	are	be	VBP
cord-259237-aty0vrat	388	31	activated	activate	VBN
cord-259237-aty0vrat	388	32	to	to	TO
cord-259237-aty0vrat	388	33	promote	promote	VB
cord-259237-aty0vrat	388	34	african	african	JJ
cord-259237-aty0vrat	388	35	swine	swine	NN
cord-259237-aty0vrat	388	36	fever	fever	NN
cord-259237-aty0vrat	388	37	virus	virus	NN
cord-259237-aty0vrat	388	38	infection	infection	NN
cord-259237-aty0vrat	389	1	Er	er	UH
cord-259237-aty0vrat	389	2	stress	stress	NN
cord-259237-aty0vrat	389	3	,	,	,
cord-259237-aty0vrat	389	4	autophagy	autophagy	NN
cord-259237-aty0vrat	389	5	,	,	,
cord-259237-aty0vrat	389	6	and	and	CC
cord-259237-aty0vrat	389	7	rna	rna	NNP
cord-259237-aty0vrat	389	8	viruses	virus	NNS
cord-259237-aty0vrat	389	9	Short	short	JJ
cord-259237-aty0vrat	389	10	communication	communication	NN
cord-259237-aty0vrat	389	11	:	:	:
cord-259237-aty0vrat	390	1	Activating	activate	VBG
cord-259237-aty0vrat	390	2	transcription	transcription	NN
cord-259237-aty0vrat	390	3	factor	factor	NN
cord-259237-aty0vrat	390	4	4	4	CD
cord-259237-aty0vrat	391	1	(	(	-LRB-
cord-259237-aty0vrat	391	2	ATF4	ATF4	NNP
cord-259237-aty0vrat	391	3	)	)	-RRB-
cord-259237-aty0vrat	391	4	promotes	promote	VBZ
cord-259237-aty0vrat	391	5	HIV	HIV	NNP
cord-259237-aty0vrat	391	6	type	type	NN
cord-259237-aty0vrat	391	7	1	1	CD
cord-259237-aty0vrat	391	8	activation	activation	NN
cord-259237-aty0vrat	391	9	PB1-F2	PB1-F2	NNP
cord-259237-aty0vrat	391	10	attenuates	attenuate	VBZ
cord-259237-aty0vrat	391	11	virulence	virulence	NN
cord-259237-aty0vrat	391	12	of	of	IN
cord-259237-aty0vrat	391	13	highly	highly	RB
cord-259237-aty0vrat	391	14	pathogenic	pathogenic	JJ
cord-259237-aty0vrat	391	15	avian	avian	JJ
cord-259237-aty0vrat	391	16	H5N1	H5N1	NNP
cord-259237-aty0vrat	391	17	influenza	influenza	NN
cord-259237-aty0vrat	391	18	virus	virus	NN
cord-259237-aty0vrat	391	19	in	in	IN
cord-259237-aty0vrat	391	20	chickens	chicken	NNS
cord-259237-aty0vrat	391	21	Dengue	Dengue	NNP
cord-259237-aty0vrat	391	22	virus	virus	NN
cord-259237-aty0vrat	391	23	modulates	modulate	VBZ
cord-259237-aty0vrat	391	24	the	the	DT
cord-259237-aty0vrat	391	25	unfolded	unfolded	JJ
cord-259237-aty0vrat	391	26	protein	protein	NN
cord-259237-aty0vrat	391	27	response	response	NN
cord-259237-aty0vrat	391	28	in	in	IN
cord-259237-aty0vrat	391	29	a	a	DT
cord-259237-aty0vrat	391	30	time	time	NN
cord-259237-aty0vrat	391	31	-	-	HYPH
cord-259237-aty0vrat	391	32	dependent	dependent	JJ
cord-259237-aty0vrat	391	33	manner	manner	NN
cord-259237-aty0vrat	392	1	Cytomegalovirus	Cytomegalovirus	NNP
cord-259237-aty0vrat	392	2	downregulates	downregulate	VBZ
cord-259237-aty0vrat	392	3	IRE1	IRE1	NNP
cord-259237-aty0vrat	392	4	to	to	TO
cord-259237-aty0vrat	392	5	repress	repress	VB
cord-259237-aty0vrat	392	6	the	the	DT
cord-259237-aty0vrat	392	7	unfolded	unfolded	JJ
cord-259237-aty0vrat	392	8	protein	protein	NN
cord-259237-aty0vrat	392	9	response	response	NN
cord-259237-aty0vrat	393	1	The	the	DT
cord-259237-aty0vrat	393	2	SARS	SARS	NNP
cord-259237-aty0vrat	393	3	coronavirus	coronavirus	NN
cord-259237-aty0vrat	394	1	3a	3a	NNP
cord-259237-aty0vrat	394	2	protein	protein	NNP
cord-259237-aty0vrat	394	3	causes	cause	VBZ
cord-259237-aty0vrat	394	4	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	394	5	reticulum	reticulum	NN
cord-259237-aty0vrat	394	6	stress	stress	NN
cord-259237-aty0vrat	394	7	and	and	CC
cord-259237-aty0vrat	394	8	induces	induce	VBZ
cord-259237-aty0vrat	394	9	ligand	ligand	NN
cord-259237-aty0vrat	394	10	-	-	HYPH
cord-259237-aty0vrat	394	11	independent	independent	JJ
cord-259237-aty0vrat	394	12	downregulation	downregulation	NN
cord-259237-aty0vrat	394	13	of	of	IN
cord-259237-aty0vrat	394	14	the	the	DT
cord-259237-aty0vrat	394	15	type	type	NN
cord-259237-aty0vrat	394	16	1	1	CD
cord-259237-aty0vrat	394	17	interferon	interferon	NN
cord-259237-aty0vrat	394	18	receptor	receptor	NN
cord-259237-aty0vrat	394	19	The	the	DT
cord-259237-aty0vrat	394	20	HCMN	HCMN	NNP
cord-259237-aty0vrat	394	21	gene	gene	NN
cord-259237-aty0vrat	394	22	products	product	NNS
cord-259237-aty0vrat	394	23	US2	US2	NNP
cord-259237-aty0vrat	394	24	and	and	CC
cord-259237-aty0vrat	394	25	US11	US11	NNP
cord-259237-aty0vrat	394	26	target	target	NN
cord-259237-aty0vrat	395	1	MHC	MHC	NNP
cord-259237-aty0vrat	395	2	class	class	NN
cord-259237-aty0vrat	396	1	I	-PRON-	PRP
cord-259237-aty0vrat	396	2	molecules	molecule	VBZ
cord-259237-aty0vrat	396	3	for	for	IN
cord-259237-aty0vrat	396	4	degradation	degradation	NN
cord-259237-aty0vrat	396	5	in	in	IN
cord-259237-aty0vrat	396	6	the	the	DT
cord-259237-aty0vrat	396	7	cytosol	cytosol	NN
cord-259237-aty0vrat	396	8	Plasma	Plasma	NNP
cord-259237-aty0vrat	396	9	membrane	membrane	NN
cord-259237-aty0vrat	396	10	profiling	profiling	NN
cord-259237-aty0vrat	396	11	defines	define	VBZ
cord-259237-aty0vrat	396	12	an	an	DT
cord-259237-aty0vrat	396	13	expanded	expand	VBN
cord-259237-aty0vrat	396	14	class	class	NN
cord-259237-aty0vrat	396	15	of	of	IN
cord-259237-aty0vrat	396	16	cell	cell	NN
cord-259237-aty0vrat	396	17	surface	surface	NN
cord-259237-aty0vrat	396	18	proteins	protein	NNS
cord-259237-aty0vrat	396	19	selectively	selectively	RB
cord-259237-aty0vrat	396	20	targeted	target	VBN
cord-259237-aty0vrat	396	21	for	for	IN
cord-259237-aty0vrat	396	22	degradation	degradation	NN
cord-259237-aty0vrat	396	23	by	by	IN
cord-259237-aty0vrat	396	24	HCMV	HCMV	NNP
cord-259237-aty0vrat	396	25	US2	US2	NNP
cord-259237-aty0vrat	396	26	in	in	IN
cord-259237-aty0vrat	396	27	cooperation	cooperation	NN
cord-259237-aty0vrat	396	28	with	with	IN
cord-259237-aty0vrat	396	29	UL141	UL141	NNP
cord-259237-aty0vrat	396	30	Cleavage	Cleavage	NNP
cord-259237-aty0vrat	396	31	by	by	IN
cord-259237-aty0vrat	396	32	signal	signal	NN
cord-259237-aty0vrat	396	33	peptide	peptide	NN
cord-259237-aty0vrat	396	34	peptidase	peptidase	NN
cord-259237-aty0vrat	396	35	is	be	VBZ
cord-259237-aty0vrat	396	36	required	require	VBN
cord-259237-aty0vrat	396	37	for	for	IN
cord-259237-aty0vrat	396	38	the	the	DT
cord-259237-aty0vrat	396	39	degradation	degradation	NN
cord-259237-aty0vrat	396	40	of	of	IN
cord-259237-aty0vrat	396	41	selected	select	VBN
cord-259237-aty0vrat	396	42	tail	tail	NN
cord-259237-aty0vrat	396	43	-	-	HYPH
cord-259237-aty0vrat	396	44	anchored	anchor	VBN
cord-259237-aty0vrat	396	45	proteins	protein	NNS
cord-259237-aty0vrat	396	46	Signal	Signal	NNP
cord-259237-aty0vrat	396	47	peptide	peptide	JJ
cord-259237-aty0vrat	396	48	peptidase	peptidase	NN
cord-259237-aty0vrat	396	49	is	be	VBZ
cord-259237-aty0vrat	396	50	required	require	VBN
cord-259237-aty0vrat	396	51	for	for	IN
cord-259237-aty0vrat	396	52	dislocation	dislocation	NN
cord-259237-aty0vrat	396	53	from	from	IN
cord-259237-aty0vrat	396	54	the	the	DT
cord-259237-aty0vrat	396	55	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	396	56	reticulum	reticulum	NN
cord-259237-aty0vrat	397	1	The	the	DT
cord-259237-aty0vrat	397	2	TRC8	TRC8	NNP
cord-259237-aty0vrat	397	3	E3	e3	NN
cord-259237-aty0vrat	397	4	ligase	ligase	NN
cord-259237-aty0vrat	397	5	ubiquitinates	ubiquitinate	NNS
cord-259237-aty0vrat	398	1	MHC	MHC	NNP
cord-259237-aty0vrat	398	2	class	class	NN
cord-259237-aty0vrat	399	1	I	-PRON-	PRP
cord-259237-aty0vrat	399	2	molecules	molecule	NNS
cord-259237-aty0vrat	399	3	before	before	IN
cord-259237-aty0vrat	399	4	dislocation	dislocation	NN
cord-259237-aty0vrat	399	5	from	from	IN
cord-259237-aty0vrat	399	6	the	the	DT
cord-259237-aty0vrat	399	7	ER	ER	NNP
cord-259237-aty0vrat	399	8	TMEM129	TMEM129	NNP
cord-259237-aty0vrat	400	1	is	be	VBZ
cord-259237-aty0vrat	400	2	a	a	DT
cord-259237-aty0vrat	400	3	Derlin-1	Derlin-1	NNP
cord-259237-aty0vrat	400	4	associated	associated	JJ
cord-259237-aty0vrat	400	5	ERAD	ERAD	NNP
cord-259237-aty0vrat	400	6	E3	E3	NNP
cord-259237-aty0vrat	400	7	ligase	ligase	NN
cord-259237-aty0vrat	400	8	essential	essential	JJ
cord-259237-aty0vrat	400	9	for	for	IN
cord-259237-aty0vrat	400	10	virus	virus	NN
cord-259237-aty0vrat	400	11	-	-	HYPH
cord-259237-aty0vrat	400	12	induced	induce	VBN
cord-259237-aty0vrat	400	13	degradation	degradation	NN
cord-259237-aty0vrat	400	14	of	of	IN
cord-259237-aty0vrat	400	15	MHC-	MHC-	NNP
cord-259237-aty0vrat	401	1	I	-PRON-	PRP
cord-259237-aty0vrat	401	2	Identifying	identify	VBG
cord-259237-aty0vrat	401	3	the	the	DT
cord-259237-aty0vrat	401	4	ERAD	ERAD	NNP
cord-259237-aty0vrat	401	5	ubiquitin	ubiquitin	NN
cord-259237-aty0vrat	401	6	E3	e3	NN
cord-259237-aty0vrat	401	7	ligases	ligase	NNS
cord-259237-aty0vrat	401	8	for	for	IN
cord-259237-aty0vrat	401	9	viral	viral	JJ
cord-259237-aty0vrat	401	10	and	and	CC
cord-259237-aty0vrat	401	11	cellular	cellular	JJ
cord-259237-aty0vrat	401	12	targeting	targeting	NN
cord-259237-aty0vrat	401	13	of	of	IN
cord-259237-aty0vrat	401	14	MHC	MHC	NNP
cord-259237-aty0vrat	401	15	class	class	NN
cord-259237-aty0vrat	402	1	I	-PRON-	PRP
cord-259237-aty0vrat	402	2	SEL1L	sel1l	VBP
cord-259237-aty0vrat	402	3	nucleates	nucleate	VBZ
cord-259237-aty0vrat	402	4	a	a	DT
cord-259237-aty0vrat	402	5	protein	protein	NN
cord-259237-aty0vrat	402	6	complex	complex	NN
cord-259237-aty0vrat	402	7	required	require	VBN
cord-259237-aty0vrat	402	8	for	for	IN
cord-259237-aty0vrat	402	9	dislocation	dislocation	NN
cord-259237-aty0vrat	402	10	of	of	IN
cord-259237-aty0vrat	402	11	misfolded	misfolded	JJ
cord-259237-aty0vrat	402	12	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	402	13	MHC	MHC	NNP
cord-259237-aty0vrat	402	14	class	class	NN
cord-259237-aty0vrat	403	1	I	-PRON-	PRP
cord-259237-aty0vrat	403	2	ubiquitination	ubiquitination	IN
cord-259237-aty0vrat	403	3	by	by	IN
cord-259237-aty0vrat	403	4	a	a	DT
cord-259237-aty0vrat	403	5	viral	viral	JJ
cord-259237-aty0vrat	403	6	PHD	PHD	NNP
cord-259237-aty0vrat	403	7	/	/	SYM
cord-259237-aty0vrat	403	8	LAP	LAP	NNP
cord-259237-aty0vrat	403	9	finger	finger	NN
cord-259237-aty0vrat	403	10	protein	protein	NN
cord-259237-aty0vrat	403	11	Role	role	NN
cord-259237-aty0vrat	403	12	of	of	IN
cord-259237-aty0vrat	403	13	CD4	CD4	NNP
cord-259237-aty0vrat	403	14	receptor	receptor	NN
cord-259237-aty0vrat	403	15	down	down	IN
cord-259237-aty0vrat	403	16	-	-	HYPH
cord-259237-aty0vrat	403	17	regulation	regulation	NN
cord-259237-aty0vrat	403	18	during	during	IN
cord-259237-aty0vrat	403	19	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	403	20	infection	infection	NN
cord-259237-aty0vrat	403	21	Mechanisms	Mechanisms	NNPS
cord-259237-aty0vrat	403	22	of	of	IN
cord-259237-aty0vrat	403	23	CD4	CD4	NNP
cord-259237-aty0vrat	403	24	downregulation	downregulation	NN
cord-259237-aty0vrat	403	25	by	by	IN
cord-259237-aty0vrat	403	26	the	the	DT
cord-259237-aty0vrat	403	27	Nef	Nef	NNP
cord-259237-aty0vrat	403	28	and	and	CC
cord-259237-aty0vrat	403	29	Vpu	Vpu	NNP
cord-259237-aty0vrat	403	30	proteins	protein	NNS
cord-259237-aty0vrat	403	31	of	of	IN
cord-259237-aty0vrat	403	32	primate	primate	JJ
cord-259237-aty0vrat	403	33	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	403	34	viruses	virus	NNS
cord-259237-aty0vrat	404	1	A	a	DT
cord-259237-aty0vrat	404	2	novel	novel	JJ
cord-259237-aty0vrat	404	3	human	human	NN
cord-259237-aty0vrat	404	4	WD	WD	NNP
cord-259237-aty0vrat	404	5	protein	protein	NN
cord-259237-aty0vrat	404	6	,	,	,
cord-259237-aty0vrat	404	7	h	h	NN
cord-259237-aty0vrat	404	8	-	-	HYPH
cord-259237-aty0vrat	404	9	beta	beta	NN
cord-259237-aty0vrat	404	10	TrCp	TrCp	NNP
cord-259237-aty0vrat	404	11	,	,	,
cord-259237-aty0vrat	404	12	that	that	WDT
cord-259237-aty0vrat	404	13	interacts	interact	VBZ
cord-259237-aty0vrat	404	14	with	with	IN
cord-259237-aty0vrat	404	15	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	404	16	Vpu	Vpu	NNP
cord-259237-aty0vrat	404	17	connects	connect	VBZ
cord-259237-aty0vrat	404	18	CD4	CD4	NNP
cord-259237-aty0vrat	404	19	to	to	IN
cord-259237-aty0vrat	404	20	the	the	DT
cord-259237-aty0vrat	404	21	ER	ER	NNP
cord-259237-aty0vrat	404	22	degradation	degradation	NN
cord-259237-aty0vrat	404	23	pathway	pathway	NN
cord-259237-aty0vrat	404	24	through	through	IN
cord-259237-aty0vrat	404	25	an	an	DT
cord-259237-aty0vrat	404	26	F	F	NNP
cord-259237-aty0vrat	404	27	-	-	HYPH
cord-259237-aty0vrat	404	28	box	box	NN
cord-259237-aty0vrat	404	29	motif	motif	NN
cord-259237-aty0vrat	405	1	Hiv-1	Hiv-1	NNP
cord-259237-aty0vrat	405	2	vpu	vpu	NN
cord-259237-aty0vrat	405	3	-an	-an	HYPH
cord-259237-aty0vrat	405	4	ion	ion	NN
cord-259237-aty0vrat	405	5	channel	channel	NN
cord-259237-aty0vrat	405	6	in	in	IN
cord-259237-aty0vrat	405	7	search	search	NN
cord-259237-aty0vrat	405	8	of	of	IN
cord-259237-aty0vrat	405	9	a	a	DT
cord-259237-aty0vrat	405	10	job	job	NN
cord-259237-aty0vrat	405	11	Multilayered	multilayered	JJ
cord-259237-aty0vrat	405	12	mechanism	mechanism	NN
cord-259237-aty0vrat	405	13	of	of	IN
cord-259237-aty0vrat	405	14	CD4	CD4	NNP
cord-259237-aty0vrat	405	15	downregulation	downregulation	NN
cord-259237-aty0vrat	405	16	by	by	IN
cord-259237-aty0vrat	405	17	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	405	18	Vpu	Vpu	NNP
cord-259237-aty0vrat	405	19	involving	involve	VBG
cord-259237-aty0vrat	405	20	distinct	distinct	JJ
cord-259237-aty0vrat	405	21	ER	ER	NNP
cord-259237-aty0vrat	405	22	retention	retention	NN
cord-259237-aty0vrat	405	23	and	and	CC
cord-259237-aty0vrat	405	24	ERAD	ERAD	NNP
cord-259237-aty0vrat	406	1	targeting	target	VBG
cord-259237-aty0vrat	406	2	steps	step	NNS
cord-259237-aty0vrat	407	1	Retroviral	retroviral	JJ
cord-259237-aty0vrat	407	2	REM	rem	NN
cord-259237-aty0vrat	407	3	protein	protein	NN
cord-259237-aty0vrat	407	4	requires	require	VBZ
cord-259237-aty0vrat	407	5	processing	processing	NN
cord-259237-aty0vrat	407	6	by	by	IN
cord-259237-aty0vrat	407	7	signal	signal	NN
cord-259237-aty0vrat	407	8	peptidase	peptidase	NN
cord-259237-aty0vrat	407	9	and	and	CC
cord-259237-aty0vrat	407	10	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	407	11	for	for	IN
cord-259237-aty0vrat	407	12	nuclear	nuclear	JJ
cord-259237-aty0vrat	407	13	function	function	NN
cord-259237-aty0vrat	408	1	Cytoplasmic	cytoplasmic	JJ
cord-259237-aty0vrat	408	2	localization	localization	NN
cord-259237-aty0vrat	408	3	of	of	IN
cord-259237-aty0vrat	408	4	the	the	DT
cord-259237-aty0vrat	408	5	ORF2	ORF2	NNP
cord-259237-aty0vrat	408	6	protein	protein	NN
cord-259237-aty0vrat	408	7	of	of	IN
cord-259237-aty0vrat	408	8	hepatitis	hepatitis	NN
cord-259237-aty0vrat	408	9	E	e	NN
cord-259237-aty0vrat	408	10	virus	virus	NN
cord-259237-aty0vrat	408	11	is	be	VBZ
cord-259237-aty0vrat	408	12	dependent	dependent	JJ
cord-259237-aty0vrat	408	13	on	on	IN
cord-259237-aty0vrat	408	14	its	-PRON-	PRP$
cord-259237-aty0vrat	408	15	ability	ability	NN
cord-259237-aty0vrat	408	16	to	to	TO
cord-259237-aty0vrat	408	17	undergo	undergo	VB
cord-259237-aty0vrat	408	18	retrotranslocation	retrotranslocation	NN
cord-259237-aty0vrat	408	19	from	from	IN
cord-259237-aty0vrat	408	20	the	the	DT
cord-259237-aty0vrat	408	21	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	408	22	reticulum	reticulum	NN
cord-259237-aty0vrat	409	1	The	the	DT
cord-259237-aty0vrat	409	2	polyomaviridae	polyomaviridae	NN
cord-259237-aty0vrat	409	3	:	:	:
cord-259237-aty0vrat	409	4	Contributions	contribution	NNS
cord-259237-aty0vrat	409	5	of	of	IN
cord-259237-aty0vrat	409	6	virus	virus	NN
cord-259237-aty0vrat	409	7	structure	structure	NN
cord-259237-aty0vrat	409	8	to	to	IN
cord-259237-aty0vrat	409	9	our	-PRON-	PRP$
cord-259237-aty0vrat	409	10	understanding	understanding	NN
cord-259237-aty0vrat	409	11	of	of	IN
cord-259237-aty0vrat	409	12	virus	virus	NN
cord-259237-aty0vrat	409	13	receptors	receptor	NNS
cord-259237-aty0vrat	409	14	and	and	CC
cord-259237-aty0vrat	409	15	infectious	infectious	JJ
cord-259237-aty0vrat	409	16	entry	entry	NN
cord-259237-aty0vrat	410	1	Murine	murine	JJ
cord-259237-aty0vrat	410	2	polyomavirus	polyomavirus	NN
cord-259237-aty0vrat	410	3	requires	require	VBZ
cord-259237-aty0vrat	410	4	the	the	DT
cord-259237-aty0vrat	410	5	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	410	6	reticulum	reticulum	NN
cord-259237-aty0vrat	410	7	protein	protein	NN
cord-259237-aty0vrat	410	8	Derlin-2	Derlin-2	NNP
cord-259237-aty0vrat	410	9	to	to	TO
cord-259237-aty0vrat	410	10	initiate	initiate	VB
cord-259237-aty0vrat	410	11	infection	infection	NN
cord-259237-aty0vrat	410	12	Simian	simian	JJ
cord-259237-aty0vrat	410	13	virus	virus	NN
cord-259237-aty0vrat	410	14	40	40	CD
cord-259237-aty0vrat	410	15	depends	depend	VBZ
cord-259237-aty0vrat	410	16	on	on	IN
cord-259237-aty0vrat	410	17	er	er	UH
cord-259237-aty0vrat	410	18	protein	protein	NN
cord-259237-aty0vrat	410	19	folding	folding	NN
cord-259237-aty0vrat	410	20	and	and	CC
cord-259237-aty0vrat	410	21	quality	quality	NN
cord-259237-aty0vrat	410	22	control	control	NN
cord-259237-aty0vrat	410	23	factors	factor	NNS
cord-259237-aty0vrat	410	24	for	for	IN
cord-259237-aty0vrat	410	25	entry	entry	NN
cord-259237-aty0vrat	410	26	into	into	IN
cord-259237-aty0vrat	410	27	host	host	NN
cord-259237-aty0vrat	410	28	cells	cell	NNS
cord-259237-aty0vrat	411	1	Coronaviruses	coronaviruse	NNS
cord-259237-aty0vrat	411	2	Hijack	hijack	VBP
cord-259237-aty0vrat	411	3	the	the	DT
cord-259237-aty0vrat	411	4	LC3-I	lc3-i	NN
cord-259237-aty0vrat	411	5	-	-	HYPH
cord-259237-aty0vrat	411	6	positive	positive	JJ
cord-259237-aty0vrat	411	7	EDEMosomes	edemosome	NNS
cord-259237-aty0vrat	411	8	,	,	,
cord-259237-aty0vrat	411	9	ER	ER	NNP
cord-259237-aty0vrat	411	10	-	-	HYPH
cord-259237-aty0vrat	411	11	derived	derive	VBN
cord-259237-aty0vrat	411	12	vesicles	vesicle	NNS
cord-259237-aty0vrat	411	13	exporting	export	VBG
cord-259237-aty0vrat	411	14	short	short	RB
cord-259237-aty0vrat	411	15	-	-	HYPH
cord-259237-aty0vrat	411	16	lived	live	VBN
cord-259237-aty0vrat	411	17	ERAD	ERAD	NNP
cord-259237-aty0vrat	411	18	regulators	regulator	NNS
cord-259237-aty0vrat	411	19	,	,	,
cord-259237-aty0vrat	411	20	for	for	IN
cord-259237-aty0vrat	411	21	replication	replication	NN
cord-259237-aty0vrat	412	1	How	how	WRB
cord-259237-aty0vrat	412	2	viruses	virus	NNS
cord-259237-aty0vrat	412	3	hijack	hijack	VBP
cord-259237-aty0vrat	412	4	the	the	DT
cord-259237-aty0vrat	412	5	ERAD	ERAD	NNP
cord-259237-aty0vrat	412	6	tuning	tuning	NN
cord-259237-aty0vrat	412	7	machinery	machinery	NN
cord-259237-aty0vrat	412	8	Electron	electron	NN
cord-259237-aty0vrat	412	9	tomography	tomography	NN
cord-259237-aty0vrat	412	10	analysis	analysis	NN
cord-259237-aty0vrat	412	11	of	of	IN
cord-259237-aty0vrat	412	12	envelope	envelope	NN
cord-259237-aty0vrat	412	13	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	412	14	trimers	trimer	NNS
cord-259237-aty0vrat	412	15	on	on	IN
cord-259237-aty0vrat	412	16	HIV	HIV	NNP
cord-259237-aty0vrat	412	17	and	and	CC
cord-259237-aty0vrat	412	18	simian	simian	JJ
cord-259237-aty0vrat	412	19	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	412	20	virus	virus	NN
cord-259237-aty0vrat	412	21	virions	virion	VBZ
cord-259237-aty0vrat	412	22	Distribution	distribution	NN
cord-259237-aty0vrat	412	23	and	and	CC
cord-259237-aty0vrat	412	24	three	three	CD
cord-259237-aty0vrat	412	25	-	-	HYPH
cord-259237-aty0vrat	412	26	dimensional	dimensional	JJ
cord-259237-aty0vrat	412	27	structure	structure	NN
cord-259237-aty0vrat	412	28	of	of	IN
cord-259237-aty0vrat	412	29	AIDS	AIDS	NNP
cord-259237-aty0vrat	412	30	virus	virus	NN
cord-259237-aty0vrat	412	31	envelope	envelope	NN
cord-259237-aty0vrat	412	32	spikes	spike	VBZ
cord-259237-aty0vrat	412	33	Retrovirus	Retrovirus	NNP
cord-259237-aty0vrat	412	34	envelope	envelope	NN
cord-259237-aty0vrat	412	35	protein	protein	NN
cord-259237-aty0vrat	412	36	complex	complex	JJ
cord-259237-aty0vrat	412	37	structure	structure	NN
cord-259237-aty0vrat	412	38	in	in	IN
cord-259237-aty0vrat	412	39	situ	situ	NNS
cord-259237-aty0vrat	412	40	studied	study	VBN
cord-259237-aty0vrat	412	41	by	by	IN
cord-259237-aty0vrat	412	42	cryo	cryo	NN
cord-259237-aty0vrat	412	43	-	-	HYPH
cord-259237-aty0vrat	412	44	electron	electron	NN
cord-259237-aty0vrat	412	45	tomography	tomography	NN
cord-259237-aty0vrat	412	46	Three	three	CD
cord-259237-aty0vrat	412	47	-	-	HYPH
cord-259237-aty0vrat	412	48	dimensional	dimensional	JJ
cord-259237-aty0vrat	412	49	structure	structure	NN
cord-259237-aty0vrat	412	50	of	of	IN
cord-259237-aty0vrat	412	51	herpes	herpes	NNP
cord-259237-aty0vrat	412	52	simplex	simplex	NNP
cord-259237-aty0vrat	412	53	virus	virus	NN
cord-259237-aty0vrat	412	54	from	from	IN
cord-259237-aty0vrat	412	55	cryo	cryo	NN
cord-259237-aty0vrat	412	56	-	-	HYPH
cord-259237-aty0vrat	412	57	electron	electron	NN
cord-259237-aty0vrat	412	58	tomography	tomography	NN
cord-259237-aty0vrat	413	1	Paramyxovirus	paramyxovirus	JJ
cord-259237-aty0vrat	413	2	ultrastructure	ultrastructure	NN
cord-259237-aty0vrat	413	3	and	and	CC
cord-259237-aty0vrat	413	4	genome	genome	NN
cord-259237-aty0vrat	413	5	packaging	packaging	NN
cord-259237-aty0vrat	413	6	:	:	:
cord-259237-aty0vrat	414	1	Cryo	cryo	NN
cord-259237-aty0vrat	414	2	-	-	HYPH
cord-259237-aty0vrat	414	3	electron	electron	NN
cord-259237-aty0vrat	414	4	tomography	tomography	NN
cord-259237-aty0vrat	414	5	of	of	IN
cord-259237-aty0vrat	414	6	sendai	sendai	NNP
cord-259237-aty0vrat	414	7	virus	virus	NN
cord-259237-aty0vrat	414	8	Zernike	Zernike	NNP
cord-259237-aty0vrat	414	9	phase	phase	NN
cord-259237-aty0vrat	415	1	contrast	contrast	NN
cord-259237-aty0vrat	415	2	electron	electron	NN
cord-259237-aty0vrat	415	3	microscopy	microscopy	NN
cord-259237-aty0vrat	415	4	of	of	IN
cord-259237-aty0vrat	415	5	ice	ice	NN
cord-259237-aty0vrat	415	6	-	-	HYPH
cord-259237-aty0vrat	415	7	embedded	embed	VBN
cord-259237-aty0vrat	415	8	influenza	influenza	NN
cord-259237-aty0vrat	415	9	A	a	DT
cord-259237-aty0vrat	415	10	virus	virus	NN
cord-259237-aty0vrat	416	1	Why	why	WRB
cord-259237-aty0vrat	416	2	HIV	HIV	NNP
cord-259237-aty0vrat	416	3	virions	virion	NNS
cord-259237-aty0vrat	416	4	have	have	VBP
cord-259237-aty0vrat	416	5	low	low	JJ
cord-259237-aty0vrat	416	6	numbers	number	NNS
cord-259237-aty0vrat	416	7	of	of	IN
cord-259237-aty0vrat	416	8	envelope	envelope	NN
cord-259237-aty0vrat	416	9	spikes	spike	NNS
cord-259237-aty0vrat	416	10	:	:	:
cord-259237-aty0vrat	416	11	Implications	implication	NNS
cord-259237-aty0vrat	416	12	for	for	IN
cord-259237-aty0vrat	416	13	vaccine	vaccine	NN
cord-259237-aty0vrat	416	14	development	development	NN
cord-259237-aty0vrat	416	15	Model	Model	NNP
cord-259237-aty0vrat	416	16	for	for	IN
cord-259237-aty0vrat	416	17	intracellular	intracellular	JJ
cord-259237-aty0vrat	416	18	folding	folding	NN
cord-259237-aty0vrat	416	19	of	of	IN
cord-259237-aty0vrat	416	20	the	the	DT
cord-259237-aty0vrat	416	21	human	human	JJ
cord-259237-aty0vrat	416	22	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	416	23	virus	virus	NN
cord-259237-aty0vrat	416	24	type	type	NN
cord-259237-aty0vrat	416	25	1	1	CD
cord-259237-aty0vrat	416	26	gp120	gp120	NNP
cord-259237-aty0vrat	416	27	Secretion	secretion	NN
cord-259237-aty0vrat	416	28	of	of	IN
cord-259237-aty0vrat	416	29	a	a	DT
cord-259237-aty0vrat	416	30	truncated	truncated	JJ
cord-259237-aty0vrat	416	31	form	form	NN
cord-259237-aty0vrat	416	32	of	of	IN
cord-259237-aty0vrat	416	33	the	the	DT
cord-259237-aty0vrat	416	34	human	human	JJ
cord-259237-aty0vrat	416	35	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	416	36	virus	virus	NN
cord-259237-aty0vrat	416	37	type	type	NN
cord-259237-aty0vrat	416	38	1	1	CD
cord-259237-aty0vrat	416	39	envelope	envelope	NN
cord-259237-aty0vrat	416	40	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	416	41	Biosynthesis	Biosynthesis	NNP
cord-259237-aty0vrat	416	42	,	,	,
cord-259237-aty0vrat	416	43	cleavage	cleavage	NN
cord-259237-aty0vrat	416	44	,	,	,
cord-259237-aty0vrat	416	45	and	and	CC
cord-259237-aty0vrat	416	46	degradation	degradation	NN
cord-259237-aty0vrat	416	47	of	of	IN
cord-259237-aty0vrat	416	48	the	the	DT
cord-259237-aty0vrat	416	49	human	human	JJ
cord-259237-aty0vrat	416	50	immunodeficiency	immunodeficiency	NN
cord-259237-aty0vrat	416	51	virus	virus	NN
cord-259237-aty0vrat	416	52	1	1	CD
cord-259237-aty0vrat	416	53	envelope	envelope	NN
cord-259237-aty0vrat	416	54	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	416	55	gp160	gp160	NNP
cord-259237-aty0vrat	417	1	A	a	DT
cord-259237-aty0vrat	417	2	novel	novel	JJ
cord-259237-aty0vrat	417	3	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	417	4	restriction	restriction	NN
cord-259237-aty0vrat	417	5	factor	factor	NN
cord-259237-aty0vrat	417	6	that	that	WDT
cord-259237-aty0vrat	417	7	is	be	VBZ
cord-259237-aty0vrat	417	8	biologically	biologically	RB
cord-259237-aty0vrat	417	9	distinct	distinct	JJ
cord-259237-aty0vrat	417	10	from	from	IN
cord-259237-aty0vrat	417	11	APOBEC3	APOBEC3	NNP
cord-259237-aty0vrat	417	12	cytidine	cytidine	FW
cord-259237-aty0vrat	417	13	deaminases	deaminases	NNP
cord-259237-aty0vrat	417	14	in	in	IN
cord-259237-aty0vrat	417	15	a	a	DT
cord-259237-aty0vrat	417	16	human	human	JJ
cord-259237-aty0vrat	417	17	T	t	NN
cord-259237-aty0vrat	417	18	cell	cell	NN
cord-259237-aty0vrat	417	19	line	line	NN
cord-259237-aty0vrat	418	1	CEM	CEM	NNP
cord-259237-aty0vrat	419	1	The	the	DT
cord-259237-aty0vrat	419	2	mitochondrial	mitochondrial	JJ
cord-259237-aty0vrat	419	3	translocator	translocator	NN
cord-259237-aty0vrat	419	4	protein	protein	NN
cord-259237-aty0vrat	419	5	,	,	,
cord-259237-aty0vrat	419	6	TSPO	TSPO	NNP
cord-259237-aty0vrat	419	7	,	,	,
cord-259237-aty0vrat	419	8	inhibits	inhibit	VBZ
cord-259237-aty0vrat	419	9	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	419	10	envelope	envelope	NN
cord-259237-aty0vrat	419	11	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	419	12	biosynthesis	biosynthesis	NN
cord-259237-aty0vrat	419	13	via	via	IN
cord-259237-aty0vrat	419	14	the	the	DT
cord-259237-aty0vrat	419	15	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	419	16	reticulum	reticulum	NN
cord-259237-aty0vrat	419	17	-	-	HYPH
cord-259237-aty0vrat	419	18	associated	associate	VBN
cord-259237-aty0vrat	419	19	protein	protein	NN
cord-259237-aty0vrat	419	20	degradation	degradation	NN
cord-259237-aty0vrat	419	21	pathway	pathway	NN
cord-259237-aty0vrat	419	22	The	the	DT
cord-259237-aty0vrat	419	23	mitochondrion	mitochondrion	NN
cord-259237-aty0vrat	419	24	in	in	IN
cord-259237-aty0vrat	419	25	apoptosis	apoptosis	NN
cord-259237-aty0vrat	419	26	:	:	:
cord-259237-aty0vrat	420	1	How	how	WRB
cord-259237-aty0vrat	420	2	pandora	pandora	NNP
cord-259237-aty0vrat	420	3	's	's	POS
cord-259237-aty0vrat	420	4	box	box	NN
cord-259237-aty0vrat	420	5	opens	open	VBZ
cord-259237-aty0vrat	420	6	TSPO	TSPO	NNP
cord-259237-aty0vrat	420	7	interacts	interact	VBZ
cord-259237-aty0vrat	420	8	with	with	IN
cord-259237-aty0vrat	420	9	VDAC1	vdac1	NN
cord-259237-aty0vrat	420	10	and	and	CC
cord-259237-aty0vrat	420	11	triggers	trigger	VBZ
cord-259237-aty0vrat	420	12	a	a	DT
cord-259237-aty0vrat	420	13	ROS	ROS	NNP
cord-259237-aty0vrat	420	14	-	-	HYPH
cord-259237-aty0vrat	420	15	mediated	mediate	VBN
cord-259237-aty0vrat	420	16	inhibition	inhibition	NN
cord-259237-aty0vrat	420	17	of	of	IN
cord-259237-aty0vrat	420	18	mitochondrial	mitochondrial	JJ
cord-259237-aty0vrat	420	19	quality	quality	NN
cord-259237-aty0vrat	420	20	control	control	NN
cord-259237-aty0vrat	420	21	Elucidation	elucidation	NN
cord-259237-aty0vrat	420	22	of	of	IN
cord-259237-aty0vrat	420	23	the	the	DT
cord-259237-aty0vrat	420	24	molecular	molecular	JJ
cord-259237-aty0vrat	420	25	logic	logic	NN
cord-259237-aty0vrat	420	26	by	by	IN
cord-259237-aty0vrat	420	27	which	which	WDT
cord-259237-aty0vrat	420	28	misfolded	misfolde	VBD
cord-259237-aty0vrat	420	29	alpha	alpha	NN
cord-259237-aty0vrat	420	30	1-antitrypsin	1-antitrypsin	CD
cord-259237-aty0vrat	420	31	is	be	VBZ
cord-259237-aty0vrat	420	32	preferentially	preferentially	RB
cord-259237-aty0vrat	420	33	selected	select	VBN
cord-259237-aty0vrat	420	34	for	for	IN
cord-259237-aty0vrat	420	35	degradation	degradation	NN
cord-259237-aty0vrat	420	36	ERManI	ERManI	NNP
cord-259237-aty0vrat	420	37	(	(	-LRB-
cord-259237-aty0vrat	420	38	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	420	39	reticulum	reticulum	NN
cord-259237-aty0vrat	420	40	class	class	NN
cord-259237-aty0vrat	420	41	i	i	PRP
cord-259237-aty0vrat	420	42	alphamannosidase	alphamannosidase	NNP
cord-259237-aty0vrat	420	43	)	)	-RRB-
cord-259237-aty0vrat	420	44	is	be	VBZ
cord-259237-aty0vrat	420	45	required	require	VBN
cord-259237-aty0vrat	420	46	for	for	IN
cord-259237-aty0vrat	420	47	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	420	48	envelope	envelope	NN
cord-259237-aty0vrat	420	49	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	420	50	degradation	degradation	NN
cord-259237-aty0vrat	420	51	via	via	IN
cord-259237-aty0vrat	420	52	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	420	53	reticulum	reticulum	NN
cord-259237-aty0vrat	420	54	-	-	HYPH
cord-259237-aty0vrat	420	55	associated	associate	VBN
cord-259237-aty0vrat	420	56	protein	protein	NN
cord-259237-aty0vrat	420	57	degradation	degradation	NN
cord-259237-aty0vrat	420	58	pathway	pathway	NN
cord-259237-aty0vrat	420	59	Identification	identification	NN
cord-259237-aty0vrat	420	60	,	,	,
cord-259237-aty0vrat	420	61	expression	expression	NN
cord-259237-aty0vrat	420	62	,	,	,
cord-259237-aty0vrat	420	63	and	and	CC
cord-259237-aty0vrat	420	64	characterization	characterization	NN
cord-259237-aty0vrat	420	65	of	of	IN
cord-259237-aty0vrat	420	66	a	a	DT
cord-259237-aty0vrat	420	67	cDNA	cdna	NN
cord-259237-aty0vrat	420	68	encoding	encode	VBG
cord-259237-aty0vrat	420	69	human	human	JJ
cord-259237-aty0vrat	420	70	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	420	71	reticulum	reticulum	NN
cord-259237-aty0vrat	420	72	mannosidase	mannosidase	NN
cord-259237-aty0vrat	420	73	i	i	NNP
cord-259237-aty0vrat	420	74	,	,	,
cord-259237-aty0vrat	420	75	the	the	DT
cord-259237-aty0vrat	420	76	enzyme	enzyme	NN
cord-259237-aty0vrat	420	77	that	that	WDT
cord-259237-aty0vrat	420	78	catalyzes	catalyze	VBZ
cord-259237-aty0vrat	420	79	the	the	DT
cord-259237-aty0vrat	420	80	first	first	JJ
cord-259237-aty0vrat	420	81	mannose	mannose	NN
cord-259237-aty0vrat	420	82	trimming	trimming	NN
cord-259237-aty0vrat	420	83	step	step	NN
cord-259237-aty0vrat	420	84	in	in	IN
cord-259237-aty0vrat	420	85	mammalian	mammalian	JJ
cord-259237-aty0vrat	420	86	Asn	Asn	NNP
cord-259237-aty0vrat	420	87	-	-	HYPH
cord-259237-aty0vrat	420	88	linked	link	VBN
cord-259237-aty0vrat	420	89	oligosaccharide	oligosaccharide	NN
cord-259237-aty0vrat	420	90	biosynthesis	biosynthesis	NN
cord-259237-aty0vrat	420	91	Cloning	cloning	NN
cord-259237-aty0vrat	420	92	and	and	CC
cord-259237-aty0vrat	420	93	expression	expression	NN
cord-259237-aty0vrat	420	94	of	of	IN
cord-259237-aty0vrat	420	95	a	a	DT
cord-259237-aty0vrat	420	96	specific	specific	JJ
cord-259237-aty0vrat	420	97	human	human	JJ
cord-259237-aty0vrat	420	98	alpha	alpha	NN
cord-259237-aty0vrat	420	99	1,2-mannosidase	1,2-mannosidase	NN
cord-259237-aty0vrat	420	100	that	that	WDT
cord-259237-aty0vrat	420	101	trims	trim	VBZ
cord-259237-aty0vrat	420	102	Man(9)GlcNAc(2	man(9)glcnac(2	CD
cord-259237-aty0vrat	420	103	)	)	-RRB-
cord-259237-aty0vrat	420	104	to	to	IN
cord-259237-aty0vrat	420	105	Man(8)GlcNAc(2	Man(8)GlcNAc(2	NNP
cord-259237-aty0vrat	420	106	)	)	-RRB-
cord-259237-aty0vrat	421	1	isomer	isomer	NNP
cord-259237-aty0vrat	421	2	B	B	NNP
cord-259237-aty0vrat	421	3	during	during	IN
cord-259237-aty0vrat	421	4	N	n	CD
cord-259237-aty0vrat	421	5	-	-	HYPH
cord-259237-aty0vrat	421	6	glycan	glycan	NN
cord-259237-aty0vrat	421	7	biosynthesis	biosynthesis	NN
cord-259237-aty0vrat	421	8	Structural	structural	JJ
cord-259237-aty0vrat	421	9	basis	basis	NN
cord-259237-aty0vrat	421	10	for	for	IN
cord-259237-aty0vrat	421	11	catalysis	catalysis	NN
cord-259237-aty0vrat	421	12	and	and	CC
cord-259237-aty0vrat	421	13	inhibition	inhibition	NN
cord-259237-aty0vrat	421	14	of	of	IN
cord-259237-aty0vrat	421	15	N	n	CD
cord-259237-aty0vrat	421	16	-	-	HYPH
cord-259237-aty0vrat	421	17	glycan	glycan	NN
cord-259237-aty0vrat	421	18	processing	processing	NN
cord-259237-aty0vrat	421	19	class	class	NN
cord-259237-aty0vrat	422	1	I	-PRON-	PRP
cord-259237-aty0vrat	422	2	alpha	alpha	NN
cord-259237-aty0vrat	422	3	1,2-mannosidases	1,2-mannosidases	CD
cord-259237-aty0vrat	422	4	Role	role	NN
cord-259237-aty0vrat	422	5	of	of	IN
cord-259237-aty0vrat	422	6	the	the	DT
cord-259237-aty0vrat	422	7	cysteine	cysteine	NN
cord-259237-aty0vrat	422	8	residues	residue	NNS
cord-259237-aty0vrat	422	9	in	in	IN
cord-259237-aty0vrat	422	10	the	the	DT
cord-259237-aty0vrat	422	11	alpha1,2-mannosidase	alpha1,2-mannosidase	NNP
cord-259237-aty0vrat	422	12	involved	involve	VBN
cord-259237-aty0vrat	422	13	in	in	IN
cord-259237-aty0vrat	422	14	N	n	CD
cord-259237-aty0vrat	422	15	-	-	HYPH
cord-259237-aty0vrat	422	16	glycan	glycan	NN
cord-259237-aty0vrat	422	17	biosynthesis	biosynthesis	NN
cord-259237-aty0vrat	422	18	in	in	IN
cord-259237-aty0vrat	422	19	saccharomyces	saccharomyce	NNS
cord-259237-aty0vrat	422	20	cerevisiae	cerevisiae	NNS
cord-259237-aty0vrat	422	21	.	.	.
cord-259237-aty0vrat	423	1	The	the	DT
cord-259237-aty0vrat	423	2	conserved	conserved	JJ
cord-259237-aty0vrat	423	3	Cys340	cys340	NN
cord-259237-aty0vrat	423	4	and	and	CC
cord-259237-aty0vrat	423	5	Cys385	Cys385	NNP
cord-259237-aty0vrat	423	6	residues	residue	NNS
cord-259237-aty0vrat	423	7	form	form	VBP
cord-259237-aty0vrat	423	8	an	an	DT
cord-259237-aty0vrat	423	9	essential	essential	JJ
cord-259237-aty0vrat	423	10	disulfide	disulfide	NN
cord-259237-aty0vrat	423	11	bond	bond	NN
cord-259237-aty0vrat	423	12	Mutations	Mutations	NNPS
cord-259237-aty0vrat	423	13	in	in	IN
cord-259237-aty0vrat	423	14	the	the	DT
cord-259237-aty0vrat	423	15	alpha	alpha	NN
cord-259237-aty0vrat	423	16	1,2-mannosidase	1,2-mannosidase	CD
cord-259237-aty0vrat	423	17	gene	gene	NN
cord-259237-aty0vrat	423	18	,	,	,
cord-259237-aty0vrat	424	1	MAN1B1	MAN1B1	NNP
cord-259237-aty0vrat	424	2	,	,	,
cord-259237-aty0vrat	424	3	cause	cause	VB
cord-259237-aty0vrat	424	4	autosomal	autosomal	JJ
cord-259237-aty0vrat	424	5	-	-	HYPH
cord-259237-aty0vrat	424	6	recessive	recessive	JJ
cord-259237-aty0vrat	424	7	intellectual	intellectual	JJ
cord-259237-aty0vrat	424	8	disability	disability	NN
cord-259237-aty0vrat	424	9	Somatic	somatic	JJ
cord-259237-aty0vrat	424	10	overgrowth	overgrowth	NN
cord-259237-aty0vrat	424	11	associated	associate	VBN
cord-259237-aty0vrat	424	12	with	with	IN
cord-259237-aty0vrat	424	13	homozygous	homozygous	JJ
cord-259237-aty0vrat	424	14	mutations	mutation	NNS
cord-259237-aty0vrat	424	15	in	in	IN
cord-259237-aty0vrat	424	16	both	both	DT
cord-259237-aty0vrat	424	17	MAN1B	MAN1B	NNS
cord-259237-aty0vrat	424	18	!	!	.
cord-259237-aty0vrat	425	1	and	and	CC
cord-259237-aty0vrat	425	2	SEC23A.	SEC23A.	``
cord-259237-aty0vrat	425	3	Cold	Cold	NNP
cord-259237-aty0vrat	425	4	Spring	Spring	NNP
cord-259237-aty0vrat	425	5	Harb	Harb	NNP
cord-259237-aty0vrat	425	6	.	.	.
cord-259237-aty0vrat	426	1	Mol	Mol	NNP
cord-259237-aty0vrat	426	2	.	.	.
cord-259237-aty0vrat	427	1	Case	case	NN
cord-259237-aty0vrat	427	2	Stud	Stud	NNP
cord-259237-aty0vrat	427	3	A	a	DT
cord-259237-aty0vrat	427	4	golgi	golgi	NN
cord-259237-aty0vrat	427	5	-	-	HYPH
cord-259237-aty0vrat	427	6	localized	localize	VBN
cord-259237-aty0vrat	427	7	mannosidase	mannosidase	NN
cord-259237-aty0vrat	427	8	(	(	-LRB-
cord-259237-aty0vrat	427	9	MAN1B1	MAN1B1	NNP
cord-259237-aty0vrat	427	10	)	)	-RRB-
cord-259237-aty0vrat	427	11	plays	play	VBZ
cord-259237-aty0vrat	427	12	a	a	DT
cord-259237-aty0vrat	427	13	non	non	JJ
cord-259237-aty0vrat	427	14	-	-	JJ
cord-259237-aty0vrat	427	15	enzymatic	enzymatic	JJ
cord-259237-aty0vrat	427	16	gatekeeper	gatekeeper	NN
cord-259237-aty0vrat	427	17	role	role	NN
cord-259237-aty0vrat	427	18	in	in	IN
cord-259237-aty0vrat	427	19	protein	protein	NN
cord-259237-aty0vrat	427	20	biosynthetic	biosynthetic	JJ
cord-259237-aty0vrat	427	21	quality	quality	NN
cord-259237-aty0vrat	427	22	control	control	NN
cord-259237-aty0vrat	427	23	HIV-1	HIV-1	NNP
cord-259237-aty0vrat	427	24	Vpr	Vpr	NNP
cord-259237-aty0vrat	428	1	increases	increase	VBZ
cord-259237-aty0vrat	428	2	env	env	NN
cord-259237-aty0vrat	428	3	expression	expression	NN
cord-259237-aty0vrat	428	4	by	by	IN
cord-259237-aty0vrat	428	5	preventing	prevent	VBG
cord-259237-aty0vrat	428	6	Env	Env	NNP
cord-259237-aty0vrat	428	7	from	from	IN
cord-259237-aty0vrat	428	8	endoplasmic	endoplasmic	JJ
cord-259237-aty0vrat	428	9	reticulum	reticulum	NN
cord-259237-aty0vrat	428	10	-	-	HYPH
cord-259237-aty0vrat	428	11	associated	associate	VBN
cord-259237-aty0vrat	428	12	protein	protein	NN
cord-259237-aty0vrat	428	13	degradation	degradation	NN
cord-259237-aty0vrat	428	14	(	(	-LRB-
cord-259237-aty0vrat	428	15	ERAD	ERAD	NNP
cord-259237-aty0vrat	428	16	)	)	-RRB-
cord-259237-aty0vrat	428	17	Activation	Activation	NNP
cord-259237-aty0vrat	428	18	of	of	IN
cord-259237-aty0vrat	428	19	ERAD	ERAD	NNP
cord-259237-aty0vrat	428	20	pathway	pathway	NN
cord-259237-aty0vrat	428	21	by	by	IN
cord-259237-aty0vrat	428	22	human	human	JJ
cord-259237-aty0vrat	428	23	hepatitis	hepatitis	NN
cord-259237-aty0vrat	428	24	B	B	NNP
cord-259237-aty0vrat	428	25	virus	virus	NN
cord-259237-aty0vrat	428	26	modulates	modulate	VBZ
cord-259237-aty0vrat	428	27	viral	viral	JJ
cord-259237-aty0vrat	428	28	and	and	CC
cord-259237-aty0vrat	428	29	subviral	subviral	JJ
cord-259237-aty0vrat	428	30	particle	particle	NN
cord-259237-aty0vrat	428	31	production	production	NN
cord-259237-aty0vrat	428	32	Role	role	NN
cord-259237-aty0vrat	428	33	of	of	IN
cord-259237-aty0vrat	428	34	the	the	DT
cord-259237-aty0vrat	428	35	endoplasmic	endoplasmic	NN
cord-259237-aty0vrat	428	36	reticulum	reticulum	NN
cord-259237-aty0vrat	428	37	-	-	HYPH
cord-259237-aty0vrat	428	38	associated	associate	VBN
cord-259237-aty0vrat	428	39	degradation	degradation	NN
cord-259237-aty0vrat	428	40	(	(	-LRB-
cord-259237-aty0vrat	428	41	ERAD	ERAD	NNP
cord-259237-aty0vrat	428	42	)	)	-RRB-
cord-259237-aty0vrat	428	43	pathway	pathway	NN
cord-259237-aty0vrat	428	44	in	in	IN
cord-259237-aty0vrat	428	45	degradation	degradation	NN
cord-259237-aty0vrat	428	46	of	of	IN
cord-259237-aty0vrat	428	47	hepatitis	hepatitis	NN
cord-259237-aty0vrat	428	48	C	C	NNP
cord-259237-aty0vrat	428	49	virus	virus	NN
cord-259237-aty0vrat	428	50	envelope	envelope	NN
cord-259237-aty0vrat	428	51	proteins	protein	NNS
cord-259237-aty0vrat	428	52	and	and	CC
cord-259237-aty0vrat	428	53	production	production	NN
cord-259237-aty0vrat	428	54	of	of	IN
cord-259237-aty0vrat	428	55	virus	virus	NN
cord-259237-aty0vrat	428	56	particles	particle	NNS
cord-259237-aty0vrat	428	57	No	no	DT
cord-259237-aty0vrat	428	58	evidence	evidence	NN
cord-259237-aty0vrat	428	59	of	of	IN
cord-259237-aty0vrat	428	60	the	the	DT
cord-259237-aty0vrat	428	61	unfolded	unfolded	JJ
cord-259237-aty0vrat	428	62	protein	protein	NN
cord-259237-aty0vrat	428	63	response	response	NN
cord-259237-aty0vrat	428	64	in	in	IN
cord-259237-aty0vrat	428	65	patients	patient	NNS
cord-259237-aty0vrat	428	66	with	with	IN
cord-259237-aty0vrat	428	67	chronic	chronic	JJ
cord-259237-aty0vrat	428	68	hepatitis	hepatitis	NN
cord-259237-aty0vrat	428	69	C	c	NN
cord-259237-aty0vrat	428	70	virus	virus	NN
cord-259237-aty0vrat	428	71	infection	infection	NN
cord-259237-aty0vrat	428	72	Human	human	JJ
cord-259237-aty0vrat	428	73	cytomegalovirus	cytomegalovirus	NN
cord-259237-aty0vrat	428	74	glycoproteins	glycoprotein	VBZ
cord-259237-aty0vrat	428	75	Human	human	JJ
cord-259237-aty0vrat	428	76	cytomegalovirus	cytomegalovirus	NN
cord-259237-aty0vrat	428	77	penetrates	penetrate	VBZ
cord-259237-aty0vrat	428	78	host	host	NN
cord-259237-aty0vrat	428	79	cells	cell	NNS
cord-259237-aty0vrat	428	80	by	by	IN
cord-259237-aty0vrat	428	81	ph	ph	JJ
cord-259237-aty0vrat	428	82	-	-	JJ
cord-259237-aty0vrat	428	83	independent	independent	JJ
cord-259237-aty0vrat	428	84	fusion	fusion	NN
cord-259237-aty0vrat	428	85	at	at	IN
cord-259237-aty0vrat	428	86	the	the	DT
cord-259237-aty0vrat	428	87	cell	cell	NN
cord-259237-aty0vrat	428	88	surface	surface	NN
cord-259237-aty0vrat	428	89	Human	human	JJ
cord-259237-aty0vrat	428	90	cytomegalovirus	cytomegalovirus	NN
cord-259237-aty0vrat	428	91	gH	gh	NN
cord-259237-aty0vrat	428	92	/	/	SYM
cord-259237-aty0vrat	428	93	gL	gL	NNP
cord-259237-aty0vrat	428	94	/	/	SYM
cord-259237-aty0vrat	428	95	gO	gO	NNP
cord-259237-aty0vrat	428	96	promotes	promote	VBZ
cord-259237-aty0vrat	428	97	the	the	DT
cord-259237-aty0vrat	428	98	fusion	fusion	NN
cord-259237-aty0vrat	428	99	step	step	NN
cord-259237-aty0vrat	428	100	of	of	IN
cord-259237-aty0vrat	428	101	entry	entry	NN
cord-259237-aty0vrat	428	102	into	into	IN
cord-259237-aty0vrat	428	103	all	all	DT
cord-259237-aty0vrat	428	104	cell	cell	NN
cord-259237-aty0vrat	428	105	types	type	NNS
cord-259237-aty0vrat	428	106	,	,	,
cord-259237-aty0vrat	428	107	whereas	whereas	IN
cord-259237-aty0vrat	428	108	gH	gH	NNP
cord-259237-aty0vrat	428	109	/	/	SYM
cord-259237-aty0vrat	428	110	gL	gL	NNP
cord-259237-aty0vrat	428	111	/	/	SYM
cord-259237-aty0vrat	428	112	UL128	UL128	NNP
cord-259237-aty0vrat	428	113	-	-	HYPH
cord-259237-aty0vrat	428	114	131	131	CD
cord-259237-aty0vrat	428	115	broadens	broaden	VBZ
cord-259237-aty0vrat	428	116	virus	virus	NN
cord-259237-aty0vrat	428	117	tropism	tropism	NN
cord-259237-aty0vrat	428	118	through	through	IN
cord-259237-aty0vrat	428	119	a	a	DT
cord-259237-aty0vrat	428	120	distinct	distinct	JJ
cord-259237-aty0vrat	428	121	mechanism	mechanism	NN
cord-259237-aty0vrat	429	1	A	a	DT
cord-259237-aty0vrat	429	2	novel	novel	JJ
cord-259237-aty0vrat	429	3	herpes	herpes	NN
cord-259237-aty0vrat	429	4	simplex	simplex	NN
cord-259237-aty0vrat	429	5	virus	virus	NN
cord-259237-aty0vrat	429	6	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	429	7	,	,	,
cord-259237-aty0vrat	429	8	gL	gL	NNP
cord-259237-aty0vrat	429	9	,	,	,
cord-259237-aty0vrat	429	10	forms	form	VBZ
cord-259237-aty0vrat	429	11	a	a	DT
cord-259237-aty0vrat	429	12	complex	complex	NN
cord-259237-aty0vrat	429	13	with	with	IN
cord-259237-aty0vrat	429	14	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	429	15	h	h	NN
cord-259237-aty0vrat	429	16	(	(	-LRB-
cord-259237-aty0vrat	429	17	gh	gh	NNP
cord-259237-aty0vrat	429	18	)	)	-RRB-
cord-259237-aty0vrat	429	19	and	and	CC
cord-259237-aty0vrat	429	20	affects	affect	VBZ
cord-259237-aty0vrat	429	21	normal	normal	JJ
cord-259237-aty0vrat	429	22	folding	folding	NN
cord-259237-aty0vrat	429	23	and	and	CC
cord-259237-aty0vrat	429	24	surface	surface	NN
cord-259237-aty0vrat	429	25	expression	expression	NN
cord-259237-aty0vrat	429	26	of	of	IN
cord-259237-aty0vrat	429	27	gH	gH	NNP
cord-259237-aty0vrat	429	28	Human	human	NN
cord-259237-aty0vrat	429	29	cytomegalovirus	cytomegalovirus	NN
cord-259237-aty0vrat	429	30	gH	gh	NN
cord-259237-aty0vrat	429	31	stability	stability	NN
cord-259237-aty0vrat	429	32	and	and	CC
cord-259237-aty0vrat	429	33	trafficking	trafficking	NN
cord-259237-aty0vrat	429	34	are	be	VBP
cord-259237-aty0vrat	429	35	regulated	regulate	VBN
cord-259237-aty0vrat	429	36	by	by	IN
cord-259237-aty0vrat	429	37	ER	ER	NNP
cord-259237-aty0vrat	429	38	-	-	HYPH
cord-259237-aty0vrat	429	39	associated	associate	VBN
cord-259237-aty0vrat	429	40	degradation	degradation	NN
cord-259237-aty0vrat	429	41	and	and	CC
cord-259237-aty0vrat	429	42	transmembrane	transmembrane	NN
cord-259237-aty0vrat	429	43	architecture	architecture	NN
cord-259237-aty0vrat	429	44	Characterization	characterization	NN
cord-259237-aty0vrat	429	45	of	of	IN
cord-259237-aty0vrat	429	46	early	early	JJ
cord-259237-aty0vrat	429	47	EDEM1	edem1	NN
cord-259237-aty0vrat	429	48	protein	protein	NN
cord-259237-aty0vrat	429	49	maturation	maturation	NN
cord-259237-aty0vrat	429	50	events	event	NNS
cord-259237-aty0vrat	429	51	and	and	CC
cord-259237-aty0vrat	429	52	their	-PRON-	PRP$
cord-259237-aty0vrat	429	53	functional	functional	JJ
cord-259237-aty0vrat	429	54	implications	implication	NNS
cord-259237-aty0vrat	429	55	Role	role	NN
cord-259237-aty0vrat	429	56	of	of	IN
cord-259237-aty0vrat	429	57	EDEM	EDEM	NNP
cord-259237-aty0vrat	429	58	in	in	IN
cord-259237-aty0vrat	429	59	the	the	DT
cord-259237-aty0vrat	429	60	release	release	NN
cord-259237-aty0vrat	429	61	of	of	IN
cord-259237-aty0vrat	429	62	misfolded	misfolde	VBN
cord-259237-aty0vrat	429	63	glycoproteins	glycoprotein	NNS
cord-259237-aty0vrat	429	64	from	from	IN
cord-259237-aty0vrat	429	65	the	the	DT
cord-259237-aty0vrat	429	66	calnexin	calnexin	NNP
cord-259237-aty0vrat	429	67	cycle	cycle	NN
cord-259237-aty0vrat	429	68	EDEM1	edem1	IN
cord-259237-aty0vrat	429	69	recognition	recognition	NN
cord-259237-aty0vrat	429	70	and	and	CC
cord-259237-aty0vrat	429	71	delivery	delivery	NN
cord-259237-aty0vrat	429	72	of	of	IN
cord-259237-aty0vrat	429	73	misfolded	misfolde	VBN
cord-259237-aty0vrat	429	74	proteins	protein	NNS
cord-259237-aty0vrat	429	75	to	to	IN
cord-259237-aty0vrat	429	76	the	the	DT
cord-259237-aty0vrat	429	77	SEL1L	sel1l	NN
cord-259237-aty0vrat	429	78	-	-	HYPH
cord-259237-aty0vrat	429	79	containing	contain	VBG
cord-259237-aty0vrat	429	80	ERAD	ERAD	NNP
cord-259237-aty0vrat	429	81	complex	complex	JJ
cord-259237-aty0vrat	429	82	Golgi	Golgi	NNP
cord-259237-aty0vrat	429	83	localization	localization	NN
cord-259237-aty0vrat	429	84	of	of	IN
cord-259237-aty0vrat	430	1	ERManI	ERManI	NNP
cord-259237-aty0vrat	430	2	defines	define	VBZ
cord-259237-aty0vrat	430	3	spatial	spatial	JJ
cord-259237-aty0vrat	430	4	separation	separation	NN
cord-259237-aty0vrat	430	5	of	of	IN
cord-259237-aty0vrat	430	6	the	the	DT
cord-259237-aty0vrat	430	7	mammalian	mammalian	JJ
cord-259237-aty0vrat	430	8	glycoprotein	glycoprotein	NN
cord-259237-aty0vrat	430	9	quality	quality	NN
cord-259237-aty0vrat	430	10	control	control	NN
cord-259237-aty0vrat	430	11	system	system	NN
cord-259237-aty0vrat	431	1	The	the	DT
cord-259237-aty0vrat	431	2	authors	author	NNS
cord-259237-aty0vrat	431	3	declare	declare	VBP
cord-259237-aty0vrat	431	4	no	no	DT
cord-259237-aty0vrat	431	5	conflict	conflict	NN
cord-259237-aty0vrat	431	6	of	of	IN
cord-259237-aty0vrat	431	7	interest	interest	NN
cord-259237-aty0vrat	431	8	.	.	.