id	sid	tid	token	lemma	pos
cord-104162-fe51v2pt	1	1	key	key	JJ
cord-104162-fe51v2pt	2	1	:	:	:
cord-104162-fe51v2pt	2	2	cord-104162-fe51v2pt	cord-104162-fe51v2pt	NNS
cord-104162-fe51v2pt	2	3	authors	author	NNS
cord-104162-fe51v2pt	2	4	:	:	:
cord-104162-fe51v2pt	2	5	Zhang	Zhang	NNP
cord-104162-fe51v2pt	2	6	,	,	,
cord-104162-fe51v2pt	2	7	Chiyu	Chiyu	NNP
cord-104162-fe51v2pt	2	8	;	;	:
cord-104162-fe51v2pt	2	9	Forsdyke	Forsdyke	NNP
cord-104162-fe51v2pt	2	10	,	,	,
cord-104162-fe51v2pt	2	11	Donald	Donald	NNP
cord-104162-fe51v2pt	2	12	R.	R.	NNP
cord-104162-fe51v2pt	2	13	title	title	NN
cord-104162-fe51v2pt	2	14	:	:	:
cord-104162-fe51v2pt	3	1	Potential	potential	JJ
cord-104162-fe51v2pt	3	2	Achilles	Achilles	NNP
cord-104162-fe51v2pt	3	3	heels	heel	NNS
cord-104162-fe51v2pt	3	4	of	of	IN
cord-104162-fe51v2pt	3	5	SARS	SARS	NNP
cord-104162-fe51v2pt	3	6	-	-	HYPH
cord-104162-fe51v2pt	3	7	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	3	8	displayed	display	VBN
cord-104162-fe51v2pt	3	9	by	by	IN
cord-104162-fe51v2pt	3	10	the	the	DT
cord-104162-fe51v2pt	3	11	base	base	NN
cord-104162-fe51v2pt	3	12	order	order	NN
cord-104162-fe51v2pt	3	13	-	-	HYPH
cord-104162-fe51v2pt	3	14	dependent	dependent	JJ
cord-104162-fe51v2pt	3	15	component	component	NN
cord-104162-fe51v2pt	3	16	of	of	IN
cord-104162-fe51v2pt	3	17	RNA	RNA	NNP
cord-104162-fe51v2pt	3	18	folding	fold	VBG
cord-104162-fe51v2pt	3	19	energy	energy	NN
cord-104162-fe51v2pt	3	20	date	date	NN
cord-104162-fe51v2pt	3	21	:	:	:
cord-104162-fe51v2pt	3	22	2020	2020	CD
cord-104162-fe51v2pt	3	23	-	-	HYPH
cord-104162-fe51v2pt	3	24	11	11	CD
cord-104162-fe51v2pt	3	25	-	-	HYPH
cord-104162-fe51v2pt	3	26	02	02	CD
cord-104162-fe51v2pt	3	27	journal	journal	NN
cord-104162-fe51v2pt	3	28	:	:	:
cord-104162-fe51v2pt	4	1	bioRxiv	biorxiv	IN
cord-104162-fe51v2pt	4	2	DOI	DOI	NNP
cord-104162-fe51v2pt	4	3	:	:	:
cord-104162-fe51v2pt	5	1	10.1101/2020.10.22.343673	10.1101/2020.10.22.343673	CD
cord-104162-fe51v2pt	6	1	sha	sha	NNP
cord-104162-fe51v2pt	6	2	:	:	:
cord-104162-fe51v2pt	7	1	346c93f9b0710f85109d04e8d300b7700dd884a6	346c93f9b0710f85109d04e8d300b7700dd884a6	NNP
cord-104162-fe51v2pt	7	2	doc_id	doc_id	CD
cord-104162-fe51v2pt	7	3	:	:	:
cord-104162-fe51v2pt	7	4	104162	104162	CD
cord-104162-fe51v2pt	7	5	cord_uid	cord_uid	NNS
cord-104162-fe51v2pt	7	6	:	:	:
cord-104162-fe51v2pt	8	1	fe51v2pt	fe51v2pt	NNP
cord-104162-fe51v2pt	8	2	Base	Base	NNP
cord-104162-fe51v2pt	8	3	order	order	NN
cord-104162-fe51v2pt	8	4	,	,	,
cord-104162-fe51v2pt	8	5	not	not	RB
cord-104162-fe51v2pt	8	6	composition	composition	NN
cord-104162-fe51v2pt	8	7	,	,	,
cord-104162-fe51v2pt	8	8	best	best	RB
cord-104162-fe51v2pt	8	9	reflects	reflect	VBZ
cord-104162-fe51v2pt	8	10	local	local	JJ
cord-104162-fe51v2pt	8	11	evolutionary	evolutionary	JJ
cord-104162-fe51v2pt	8	12	pressure	pressure	NN
cord-104162-fe51v2pt	8	13	for	for	IN
cord-104162-fe51v2pt	8	14	folding	folding	NN
cord-104162-fe51v2pt	8	15	of	of	IN
cord-104162-fe51v2pt	8	16	single	single	RB
cord-104162-fe51v2pt	8	17	-	-	HYPH
cord-104162-fe51v2pt	8	18	stranded	strand	VBN
cord-104162-fe51v2pt	8	19	nucleic	nucleic	JJ
cord-104162-fe51v2pt	8	20	acids	acid	NNS
cord-104162-fe51v2pt	8	21	.	.	.
cord-104162-fe51v2pt	9	1	The	the	DT
cord-104162-fe51v2pt	9	2	base	base	NN
cord-104162-fe51v2pt	9	3	order	order	NN
cord-104162-fe51v2pt	9	4	-	-	HYPH
cord-104162-fe51v2pt	9	5	dependent	dependent	JJ
cord-104162-fe51v2pt	9	6	component	component	NN
cord-104162-fe51v2pt	9	7	of	of	IN
cord-104162-fe51v2pt	9	8	folding	fold	VBG
cord-104162-fe51v2pt	9	9	energy	energy	NN
cord-104162-fe51v2pt	9	10	has	have	VBZ
cord-104162-fe51v2pt	9	11	revealed	reveal	VBN
cord-104162-fe51v2pt	9	12	a	a	DT
cord-104162-fe51v2pt	9	13	highly	highly	RB
cord-104162-fe51v2pt	9	14	conserved	conserve	VBN
cord-104162-fe51v2pt	9	15	region	region	NN
cord-104162-fe51v2pt	9	16	in	in	IN
cord-104162-fe51v2pt	9	17	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	9	18	genomes	genome	NNS
cord-104162-fe51v2pt	9	19	that	that	IN
cord-104162-fe51v2pt	9	20	associates	associate	NNS
cord-104162-fe51v2pt	9	21	with	with	IN
cord-104162-fe51v2pt	9	22	RNA	RNA	NNP
cord-104162-fe51v2pt	9	23	structure	structure	NN
cord-104162-fe51v2pt	9	24	.	.	.
cord-104162-fe51v2pt	10	1	This	this	DT
cord-104162-fe51v2pt	10	2	corresponds	correspond	VBZ
cord-104162-fe51v2pt	10	3	to	to	IN
cord-104162-fe51v2pt	10	4	a	a	DT
cord-104162-fe51v2pt	10	5	packaging	packaging	NN
cord-104162-fe51v2pt	10	6	signal	signal	NN
cord-104162-fe51v2pt	10	7	that	that	WDT
cord-104162-fe51v2pt	10	8	is	be	VBZ
cord-104162-fe51v2pt	10	9	recognized	recognize	VBN
cord-104162-fe51v2pt	10	10	by	by	IN
cord-104162-fe51v2pt	10	11	the	the	DT
cord-104162-fe51v2pt	10	12	nucleocapsid	nucleocapsid	NNP
cord-104162-fe51v2pt	10	13	domain	domain	NN
cord-104162-fe51v2pt	10	14	of	of	IN
cord-104162-fe51v2pt	10	15	the	the	DT
cord-104162-fe51v2pt	10	16	Gag	Gag	NNP
cord-104162-fe51v2pt	10	17	polyprotein	polyprotein	NN
cord-104162-fe51v2pt	10	18	.	.	.
cord-104162-fe51v2pt	11	1	Long	long	RB
cord-104162-fe51v2pt	11	2	viewed	view	VBN
cord-104162-fe51v2pt	11	3	as	as	IN
cord-104162-fe51v2pt	11	4	a	a	DT
cord-104162-fe51v2pt	11	5	potential	potential	JJ
cord-104162-fe51v2pt	11	6	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	11	7	“	"	``
cord-104162-fe51v2pt	11	8	Achilles	Achilles	NNP
cord-104162-fe51v2pt	11	9	heel	heel	NN
cord-104162-fe51v2pt	11	10	,	,	,
cord-104162-fe51v2pt	11	11	”	"	''
cord-104162-fe51v2pt	11	12	the	the	DT
cord-104162-fe51v2pt	11	13	signal	signal	NN
cord-104162-fe51v2pt	11	14	can	can	MD
cord-104162-fe51v2pt	11	15	be	be	VB
cord-104162-fe51v2pt	11	16	targeted	target	VBN
cord-104162-fe51v2pt	11	17	by	by	IN
cord-104162-fe51v2pt	11	18	a	a	DT
cord-104162-fe51v2pt	11	19	recently	recently	RB
cord-104162-fe51v2pt	11	20	described	describe	VBN
cord-104162-fe51v2pt	11	21	antiviral	antiviral	JJ
cord-104162-fe51v2pt	11	22	compound	compound	NN
cord-104162-fe51v2pt	11	23	(	(	-LRB-
cord-104162-fe51v2pt	11	24	NSC	NSC	NNP
cord-104162-fe51v2pt	11	25	260594	260594	CD
cord-104162-fe51v2pt	11	26	)	)	-RRB-
cord-104162-fe51v2pt	11	27	or	or	CC
cord-104162-fe51v2pt	11	28	by	by	IN
cord-104162-fe51v2pt	11	29	synthetic	synthetic	JJ
cord-104162-fe51v2pt	11	30	oligonucleotides	oligonucleotide	NNS
cord-104162-fe51v2pt	11	31	.	.	.
cord-104162-fe51v2pt	12	1	Thus	thus	RB
cord-104162-fe51v2pt	12	2	,	,	,
cord-104162-fe51v2pt	12	3	a	a	DT
cord-104162-fe51v2pt	12	4	conserved	conserve	VBN
cord-104162-fe51v2pt	12	5	base	base	NN
cord-104162-fe51v2pt	12	6	-	-	HYPH
cord-104162-fe51v2pt	12	7	order	order	NN
cord-104162-fe51v2pt	12	8	-	-	HYPH
cord-104162-fe51v2pt	12	9	rich	rich	JJ
cord-104162-fe51v2pt	12	10	region	region	NN
cord-104162-fe51v2pt	12	11	of	of	IN
cord-104162-fe51v2pt	12	12	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	12	13	may	may	MD
cord-104162-fe51v2pt	12	14	facilitate	facilitate	VB
cord-104162-fe51v2pt	12	15	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	12	16	attack	attack	NN
cord-104162-fe51v2pt	12	17	.	.	.
cord-104162-fe51v2pt	13	1	Although	although	IN
cord-104162-fe51v2pt	13	2	SARS	SARS	NNP
cord-104162-fe51v2pt	13	3	-	-	HYPH
cord-104162-fe51v2pt	13	4	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	13	5	differs	differ	VBZ
cord-104162-fe51v2pt	13	6	in	in	IN
cord-104162-fe51v2pt	13	7	many	many	JJ
cord-104162-fe51v2pt	13	8	respects	respect	NNS
cord-104162-fe51v2pt	13	9	from	from	IN
cord-104162-fe51v2pt	13	10	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	13	11	,	,	,
cord-104162-fe51v2pt	13	12	the	the	DT
cord-104162-fe51v2pt	13	13	same	same	JJ
cord-104162-fe51v2pt	13	14	technology	technology	NN
cord-104162-fe51v2pt	13	15	displays	display	VBZ
cord-104162-fe51v2pt	13	16	regions	region	NNS
cord-104162-fe51v2pt	13	17	with	with	IN
cord-104162-fe51v2pt	13	18	a	a	DT
cord-104162-fe51v2pt	13	19	high	high	JJ
cord-104162-fe51v2pt	13	20	base	base	NN
cord-104162-fe51v2pt	13	21	order	order	NN
cord-104162-fe51v2pt	13	22	-	-	HYPH
cord-104162-fe51v2pt	13	23	dependent	dependent	JJ
cord-104162-fe51v2pt	13	24	folding	fold	VBG
cord-104162-fe51v2pt	13	25	energy	energy	NN
cord-104162-fe51v2pt	13	26	component	component	NN
cord-104162-fe51v2pt	13	27	,	,	,
cord-104162-fe51v2pt	13	28	which	which	WDT
cord-104162-fe51v2pt	13	29	are	be	VBP
cord-104162-fe51v2pt	13	30	also	also	RB
cord-104162-fe51v2pt	13	31	highly	highly	RB
cord-104162-fe51v2pt	13	32	conserved	conserve	VBN
cord-104162-fe51v2pt	13	33	.	.	.
cord-104162-fe51v2pt	14	1	This	this	DT
cord-104162-fe51v2pt	14	2	indicates	indicate	VBZ
cord-104162-fe51v2pt	14	3	structural	structural	JJ
cord-104162-fe51v2pt	14	4	invariance	invariance	NN
cord-104162-fe51v2pt	14	5	(	(	-LRB-
cord-104162-fe51v2pt	14	6	SI	SI	NNP
cord-104162-fe51v2pt	14	7	)	)	-RRB-
cord-104162-fe51v2pt	14	8	sustained	sustain	VBN
cord-104162-fe51v2pt	14	9	by	by	IN
cord-104162-fe51v2pt	14	10	natural	natural	JJ
cord-104162-fe51v2pt	14	11	selection	selection	NN
cord-104162-fe51v2pt	14	12	.	.	.
cord-104162-fe51v2pt	15	1	While	while	IN
cord-104162-fe51v2pt	15	2	the	the	DT
cord-104162-fe51v2pt	15	3	regions	region	NNS
cord-104162-fe51v2pt	15	4	are	be	VBP
cord-104162-fe51v2pt	15	5	often	often	RB
cord-104162-fe51v2pt	15	6	also	also	RB
cord-104162-fe51v2pt	15	7	protein	protein	NN
cord-104162-fe51v2pt	15	8	-	-	HYPH
cord-104162-fe51v2pt	15	9	encoding	encoding	NN
cord-104162-fe51v2pt	15	10	(	(	-LRB-
cord-104162-fe51v2pt	15	11	e.g.	e.g.	RB
cord-104162-fe51v2pt	15	12	NSP3	NSP3	NNP
cord-104162-fe51v2pt	15	13	,	,	,
cord-104162-fe51v2pt	15	14	ORF3a	ORF3a	NNP
cord-104162-fe51v2pt	15	15	)	)	-RRB-
cord-104162-fe51v2pt	15	16	,	,	,
cord-104162-fe51v2pt	15	17	we	-PRON-	PRP
cord-104162-fe51v2pt	15	18	suggest	suggest	VBP
cord-104162-fe51v2pt	15	19	that	that	IN
cord-104162-fe51v2pt	15	20	their	-PRON-	PRP$
cord-104162-fe51v2pt	15	21	nucleic	nucleic	JJ
cord-104162-fe51v2pt	15	22	acid	acid	NN
cord-104162-fe51v2pt	15	23	level	level	NN
cord-104162-fe51v2pt	15	24	functions	function	NNS
cord-104162-fe51v2pt	15	25	–	–	:
cord-104162-fe51v2pt	15	26	such	such	JJ
cord-104162-fe51v2pt	15	27	as	as	IN
cord-104162-fe51v2pt	15	28	the	the	DT
cord-104162-fe51v2pt	15	29	ribosomal	ribosomal	JJ
cord-104162-fe51v2pt	15	30	frameshifting	frameshifte	VBG
cord-104162-fe51v2pt	15	31	element	element	NN
cord-104162-fe51v2pt	15	32	(	(	-LRB-
cord-104162-fe51v2pt	15	33	FSE	FSE	NNP
cord-104162-fe51v2pt	15	34	)	)	-RRB-
cord-104162-fe51v2pt	15	35	that	that	WDT
cord-104162-fe51v2pt	15	36	facilitates	facilitate	VBZ
cord-104162-fe51v2pt	15	37	differential	differential	JJ
cord-104162-fe51v2pt	15	38	expression	expression	NN
cord-104162-fe51v2pt	15	39	of	of	IN
cord-104162-fe51v2pt	15	40	1a	1a	CD
cord-104162-fe51v2pt	15	41	and	and	CC
cord-104162-fe51v2pt	15	42	1ab	1ab	JJ
cord-104162-fe51v2pt	15	43	polyproteins	polyprotein	NNS
cord-104162-fe51v2pt	15	44	–	–	:
cord-104162-fe51v2pt	15	45	can	can	MD
cord-104162-fe51v2pt	15	46	be	be	VB
cord-104162-fe51v2pt	15	47	considered	consider	VBN
cord-104162-fe51v2pt	15	48	potential	potential	JJ
cord-104162-fe51v2pt	15	49	“	"	``
cord-104162-fe51v2pt	15	50	Achilles	Achilles	NNP
cord-104162-fe51v2pt	15	51	heels	heel	NNS
cord-104162-fe51v2pt	15	52	”	"	''
cord-104162-fe51v2pt	15	53	for	for	IN
cord-104162-fe51v2pt	15	54	SARS	SARS	NNP
cord-104162-fe51v2pt	15	55	-	-	HYPH
cord-104162-fe51v2pt	15	56	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	15	57	,	,	,
cord-104162-fe51v2pt	15	58	perhaps	perhaps	RB
cord-104162-fe51v2pt	15	59	susceptible	susceptible	JJ
cord-104162-fe51v2pt	15	60	to	to	IN
cord-104162-fe51v2pt	15	61	therapies	therapy	NNS
cord-104162-fe51v2pt	15	62	like	like	IN
cord-104162-fe51v2pt	15	63	those	those	DT
cord-104162-fe51v2pt	15	64	envisaged	envisage	VBN
cord-104162-fe51v2pt	15	65	for	for	IN
cord-104162-fe51v2pt	15	66	AIDS	AIDS	NNP
cord-104162-fe51v2pt	15	67	.	.	.
cord-104162-fe51v2pt	16	1	The	the	DT
cord-104162-fe51v2pt	16	2	region	region	NN
cord-104162-fe51v2pt	16	3	of	of	IN
cord-104162-fe51v2pt	16	4	the	the	DT
cord-104162-fe51v2pt	16	5	FSE	FSE	NNP
cord-104162-fe51v2pt	16	6	scored	score	VBD
cord-104162-fe51v2pt	16	7	well	well	RB
cord-104162-fe51v2pt	16	8	,	,	,
cord-104162-fe51v2pt	16	9	but	but	CC
cord-104162-fe51v2pt	16	10	higher	high	JJR
cord-104162-fe51v2pt	16	11	SI	SI	NNP
cord-104162-fe51v2pt	16	12	scores	score	NNS
cord-104162-fe51v2pt	16	13	were	be	VBD
cord-104162-fe51v2pt	16	14	obtained	obtain	VBN
cord-104162-fe51v2pt	16	15	in	in	IN
cord-104162-fe51v2pt	16	16	other	other	JJ
cord-104162-fe51v2pt	16	17	regions	region	NNS
cord-104162-fe51v2pt	16	18	,	,	,
cord-104162-fe51v2pt	16	19	including	include	VBG
cord-104162-fe51v2pt	16	20	those	those	DT
cord-104162-fe51v2pt	16	21	encoding	encoding	NN
cord-104162-fe51v2pt	16	22	NSP13	NSP13	NNP
cord-104162-fe51v2pt	16	23	and	and	CC
cord-104162-fe51v2pt	16	24	the	the	DT
cord-104162-fe51v2pt	16	25	nucleocapsid	nucleocapsid	NN
cord-104162-fe51v2pt	16	26	(	(	-LRB-
cord-104162-fe51v2pt	16	27	N	N	NNP
cord-104162-fe51v2pt	16	28	)	)	-RRB-
cord-104162-fe51v2pt	16	29	protein	protein	NN
cord-104162-fe51v2pt	16	30	.	.	.
cord-104162-fe51v2pt	17	1	composition	composition	NN
cord-104162-fe51v2pt	17	2	tends	tend	VBZ
cord-104162-fe51v2pt	17	3	to	to	TO
cord-104162-fe51v2pt	17	4	reflect	reflect	VB
cord-104162-fe51v2pt	17	5	genome	genome	NN
cord-104162-fe51v2pt	17	6	-	-	HYPH
cord-104162-fe51v2pt	17	7	wide	wide	JJ
cord-104162-fe51v2pt	17	8	evolutionary	evolutionary	JJ
cord-104162-fe51v2pt	17	9	pressures	pressure	NNS
cord-104162-fe51v2pt	17	10	.	.	.
cord-104162-fe51v2pt	18	1	Just	just	RB
cord-104162-fe51v2pt	18	2	as	as	IN
cord-104162-fe51v2pt	18	3	a	a	DT
cord-104162-fe51v2pt	18	4	local	local	JJ
cord-104162-fe51v2pt	18	5	arrangement	arrangement	NN
cord-104162-fe51v2pt	18	6	of	of	IN
cord-104162-fe51v2pt	18	7	words	word	NNS
cord-104162-fe51v2pt	18	8	conveys	convey	VBZ
cord-104162-fe51v2pt	18	9	specific	specific	JJ
cord-104162-fe51v2pt	18	10	meaning	meaning	NN
cord-104162-fe51v2pt	18	11	to	to	IN
cord-104162-fe51v2pt	18	12	a	a	DT
cord-104162-fe51v2pt	18	13	text	text	NN
cord-104162-fe51v2pt	18	14	,	,	,
cord-104162-fe51v2pt	18	15	so	so	IN
cord-104162-fe51v2pt	18	16	base	base	NN
cord-104162-fe51v2pt	18	17	order	order	NN
cord-104162-fe51v2pt	18	18	better	well	RBR
cord-104162-fe51v2pt	18	19	reflects	reflect	VBZ
cord-104162-fe51v2pt	18	20	local	local	JJ
cord-104162-fe51v2pt	18	21	evolutionary	evolutionary	JJ
cord-104162-fe51v2pt	18	22	pressures	pressure	NNS
cord-104162-fe51v2pt	18	23	.	.	.
cord-104162-fe51v2pt	19	1	Base	base	NN
cord-104162-fe51v2pt	19	2	order	order	NN
cord-104162-fe51v2pt	19	3	is	be	VBZ
cord-104162-fe51v2pt	19	4	most	most	RBS
cord-104162-fe51v2pt	19	5	likely	likely	JJ
cord-104162-fe51v2pt	19	6	to	to	TO
cord-104162-fe51v2pt	19	7	be	be	VB
cord-104162-fe51v2pt	19	8	conserved	conserve	VBN
cord-104162-fe51v2pt	19	9	when	when	WRB
cord-104162-fe51v2pt	19	10	encoding	encode	VBG
cord-104162-fe51v2pt	19	11	a	a	DT
cord-104162-fe51v2pt	19	12	function	function	NN
cord-104162-fe51v2pt	19	13	critical	critical	JJ
cord-104162-fe51v2pt	19	14	for	for	IN
cord-104162-fe51v2pt	19	15	survival	survival	NN
cord-104162-fe51v2pt	19	16	.	.	.
cord-104162-fe51v2pt	20	1	Assays	assay	NNS
cord-104162-fe51v2pt	20	2	of	of	IN
cord-104162-fe51v2pt	20	3	the	the	DT
cord-104162-fe51v2pt	20	4	base	base	NN
cord-104162-fe51v2pt	20	5	order	order	NN
cord-104162-fe51v2pt	20	6	-	-	HYPH
cord-104162-fe51v2pt	20	7	dependent	dependent	JJ
cord-104162-fe51v2pt	20	8	component	component	NN
cord-104162-fe51v2pt	20	9	of	of	IN
cord-104162-fe51v2pt	20	10	the	the	DT
cord-104162-fe51v2pt	20	11	folding	folding	NN
cord-104162-fe51v2pt	20	12	energy	energy	NN
cord-104162-fe51v2pt	20	13	have	have	VBP
cord-104162-fe51v2pt	20	14	shown	show	VBN
cord-104162-fe51v2pt	20	15	that	that	IN
cord-104162-fe51v2pt	20	16	a	a	DT
cord-104162-fe51v2pt	20	17	highly	highly	RB
cord-104162-fe51v2pt	20	18	conserved	conserve	VBN
cord-104162-fe51v2pt	20	19	region	region	NN
cord-104162-fe51v2pt	20	20	,	,	,
cord-104162-fe51v2pt	20	21	in	in	IN
cord-104162-fe51v2pt	20	22	otherwise	otherwise	RB
cord-104162-fe51v2pt	20	23	rapidly	rapidly	RB
cord-104162-fe51v2pt	20	24	mutating	mutate	VBG
cord-104162-fe51v2pt	20	25	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	20	26	genomes	genome	NNS
cord-104162-fe51v2pt	20	27	,	,	,
cord-104162-fe51v2pt	20	28	associates	associate	NNS
cord-104162-fe51v2pt	20	29	with	with	IN
cord-104162-fe51v2pt	20	30	an	an	DT
cord-104162-fe51v2pt	20	31	RNA	RNA	NNP
cord-104162-fe51v2pt	20	32	structure	structure	NN
cord-104162-fe51v2pt	20	33	corresponding	correspond	VBG
cord-104162-fe51v2pt	20	34	,	,	,
cord-104162-fe51v2pt	20	35	not	not	RB
cord-104162-fe51v2pt	20	36	to	to	IN
cord-104162-fe51v2pt	20	37	a	a	DT
cord-104162-fe51v2pt	20	38	protein	protein	NN
cord-104162-fe51v2pt	20	39	-	-	HYPH
cord-104162-fe51v2pt	20	40	encoding	encode	VBG
cord-104162-fe51v2pt	20	41	function	function	NN
cord-104162-fe51v2pt	20	42	,	,	,
cord-104162-fe51v2pt	20	43	but	but	CC
cord-104162-fe51v2pt	20	44	to	to	IN
cord-104162-fe51v2pt	20	45	an	an	DT
cord-104162-fe51v2pt	20	46	RNA	RNA	NNP
cord-104162-fe51v2pt	20	47	packaging	packaging	NN
cord-104162-fe51v2pt	20	48	signal	signal	NN
cord-104162-fe51v2pt	20	49	.	.	.
cord-104162-fe51v2pt	21	1	The	the	DT
cord-104162-fe51v2pt	21	2	latter	latter	JJ
cord-104162-fe51v2pt	21	3	is	be	VBZ
cord-104162-fe51v2pt	21	4	specifically	specifically	RB
cord-104162-fe51v2pt	21	5	recognized	recognize	VBN
cord-104162-fe51v2pt	21	6	by	by	IN
cord-104162-fe51v2pt	21	7	the	the	DT
cord-104162-fe51v2pt	21	8	nucleocapsid	nucleocapsid	NNP
cord-104162-fe51v2pt	21	9	domain	domain	NN
cord-104162-fe51v2pt	21	10	of	of	IN
cord-104162-fe51v2pt	21	11	the	the	DT
cord-104162-fe51v2pt	21	12	Gag	Gag	NNP
cord-104162-fe51v2pt	21	13	polyprotein	polyprotein	NN
cord-104162-fe51v2pt	21	14	[	[	-LRB-
cord-104162-fe51v2pt	21	15	8	8	CD
cord-104162-fe51v2pt	21	16	]	]	-RRB-
cord-104162-fe51v2pt	21	17	and	and	CC
cord-104162-fe51v2pt	21	18	is	be	VBZ
cord-104162-fe51v2pt	21	19	now	now	RB
cord-104162-fe51v2pt	21	20	seen	see	VBN
cord-104162-fe51v2pt	21	21	as	as	IN
cord-104162-fe51v2pt	21	22	a	a	DT
cord-104162-fe51v2pt	21	23	potential	potential	JJ
cord-104162-fe51v2pt	21	24	"	"	``
cord-104162-fe51v2pt	21	25	Achilles	Achilles	NNP
cord-104162-fe51v2pt	21	26	heel	heel	NN
cord-104162-fe51v2pt	21	27	"	"	''
cord-104162-fe51v2pt	21	28	of	of	IN
cord-104162-fe51v2pt	21	29	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	21	30	that	that	WDT
cord-104162-fe51v2pt	21	31	can	can	MD
cord-104162-fe51v2pt	21	32	be	be	VB
cord-104162-fe51v2pt	21	33	targeted	target	VBN
cord-104162-fe51v2pt	21	34	by	by	IN
cord-104162-fe51v2pt	21	35	a	a	DT
cord-104162-fe51v2pt	21	36	recently	recently	RB
cord-104162-fe51v2pt	21	37	described	describe	VBN
cord-104162-fe51v2pt	21	38	antiviral	antiviral	JJ
cord-104162-fe51v2pt	21	39	compound	compound	NN
cord-104162-fe51v2pt	21	40	(	(	-LRB-
cord-104162-fe51v2pt	21	41	NSC	NSC	NNP
cord-104162-fe51v2pt	21	42	260594	260594	CD
cord-104162-fe51v2pt	21	43	)	)	-RRB-
cord-104162-fe51v2pt	21	44	or	or	CC
cord-104162-fe51v2pt	21	45	by	by	IN
cord-104162-fe51v2pt	21	46	synthetic	synthetic	JJ
cord-104162-fe51v2pt	21	47	oligonucleotides	oligonucleotide	NNS
cord-104162-fe51v2pt	21	48	[	[	-LRB-
cord-104162-fe51v2pt	21	49	4	4	CD
cord-104162-fe51v2pt	21	50	]	]	-RRB-
cord-104162-fe51v2pt	21	51	.	.	.
cord-104162-fe51v2pt	22	1	We	-PRON-	PRP
cord-104162-fe51v2pt	22	2	here	here	RB
cord-104162-fe51v2pt	22	3	report	report	VBP
cord-104162-fe51v2pt	22	4	similar	similar	JJ
cord-104162-fe51v2pt	22	5	highly	highly	RB
cord-104162-fe51v2pt	22	6	conserved	conserved	JJ
cord-104162-fe51v2pt	22	7	structural	structural	JJ
cord-104162-fe51v2pt	22	8	regions	region	NNS
cord-104162-fe51v2pt	22	9	of	of	IN
cord-104162-fe51v2pt	22	10	the	the	DT
cord-104162-fe51v2pt	22	11	SARS	SARS	NNP
cord-104162-fe51v2pt	22	12	-	-	HYPH
cord-104162-fe51v2pt	22	13	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	22	14	genome	genome	NN
cord-104162-fe51v2pt	22	15	,	,	,
cord-104162-fe51v2pt	22	16	one	one	CD
cord-104162-fe51v2pt	22	17	or	or	CC
cord-104162-fe51v2pt	22	18	more	more	JJR
cord-104162-fe51v2pt	22	19	of	of	IN
cord-104162-fe51v2pt	22	20	which	which	WDT
cord-104162-fe51v2pt	22	21	should	should	MD
cord-104162-fe51v2pt	22	22	be	be	VB
cord-104162-fe51v2pt	22	23	susceptible	susceptible	JJ
cord-104162-fe51v2pt	22	24	to	to	IN
cord-104162-fe51v2pt	22	25	targeting	target	VBG
cord-104162-fe51v2pt	22	26	[	[	-LRB-
cord-104162-fe51v2pt	22	27	9	9	CD
cord-104162-fe51v2pt	22	28	,	,	,
cord-104162-fe51v2pt	22	29	10	10	CD
cord-104162-fe51v2pt	22	30	]	]	-RRB-
cord-104162-fe51v2pt	22	31	.	.	.
cord-104162-fe51v2pt	23	1	We	-PRON-	PRP
cord-104162-fe51v2pt	23	2	identify	identify	VBP
cord-104162-fe51v2pt	23	3	certain	certain	JJ
cord-104162-fe51v2pt	23	4	open	open	JJ
cord-104162-fe51v2pt	23	5	reading	reading	NN
cord-104162-fe51v2pt	23	6	frames	frame	NNS
cord-104162-fe51v2pt	23	7	(	(	-LRB-
cord-104162-fe51v2pt	23	8	ORFs	ORFs	NNP
cord-104162-fe51v2pt	23	9	)	)	-RRB-
cord-104162-fe51v2pt	23	10	that	that	IN
cord-104162-fe51v2pt	23	11	,	,	,
cord-104162-fe51v2pt	23	12	because	because	IN
cord-104162-fe51v2pt	23	13	of	of	IN
cord-104162-fe51v2pt	23	14	their	-PRON-	PRP$
cord-104162-fe51v2pt	23	15	conservation	conservation	NN
cord-104162-fe51v2pt	23	16	,	,	,
cord-104162-fe51v2pt	23	17	have	have	VBP
cord-104162-fe51v2pt	23	18	so	so	RB
cord-104162-fe51v2pt	23	19	far	far	RB
cord-104162-fe51v2pt	23	20	attracted	attract	VBN
cord-104162-fe51v2pt	23	21	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	23	22	interest	interest	NN
cord-104162-fe51v2pt	23	23	mainly	mainly	RB
cord-104162-fe51v2pt	23	24	related	relate	VBN
cord-104162-fe51v2pt	23	25	to	to	IN
cord-104162-fe51v2pt	23	26	their	-PRON-	PRP$
cord-104162-fe51v2pt	23	27	functions	function	NNS
cord-104162-fe51v2pt	23	28	at	at	IN
cord-104162-fe51v2pt	23	29	the	the	DT
cord-104162-fe51v2pt	23	30	protein	protein	NN
cord-104162-fe51v2pt	23	31	level	level	NN
cord-104162-fe51v2pt	23	32	[	[	-LRB-
cord-104162-fe51v2pt	23	33	11	11	CD
cord-104162-fe51v2pt	23	34	,	,	,
cord-104162-fe51v2pt	23	35	12	12	CD
cord-104162-fe51v2pt	23	36	]	]	-RRB-
cord-104162-fe51v2pt	23	37	,	,	,
cord-104162-fe51v2pt	23	38	rather	rather	RB
cord-104162-fe51v2pt	23	39	than	than	IN
cord-104162-fe51v2pt	23	40	at	at	IN
cord-104162-fe51v2pt	23	41	the	the	DT
cord-104162-fe51v2pt	23	42	level	level	NN
cord-104162-fe51v2pt	23	43	of	of	IN
cord-104162-fe51v2pt	23	44	the	the	DT
cord-104162-fe51v2pt	23	45	corresponding	corresponding	JJ
cord-104162-fe51v2pt	23	46	,	,	,
cord-104162-fe51v2pt	23	47	yet	yet	CC
cord-104162-fe51v2pt	23	48	highly	highly	RB
cord-104162-fe51v2pt	23	49	structured	structured	JJ
cord-104162-fe51v2pt	23	50	,	,	,
cord-104162-fe51v2pt	23	51	regions	region	NNS
cord-104162-fe51v2pt	23	52	of	of	IN
cord-104162-fe51v2pt	23	53	the	the	DT
cord-104162-fe51v2pt	23	54	genome	genome	NN
cord-104162-fe51v2pt	23	55	.	.	.
cord-104162-fe51v2pt	24	1	The	the	DT
cord-104162-fe51v2pt	24	2	ribosomal	ribosomal	JJ
cord-104162-fe51v2pt	24	3	frameshift	frameshift	NN
cord-104162-fe51v2pt	24	4	element	element	NN
cord-104162-fe51v2pt	24	5	(	(	-LRB-
cord-104162-fe51v2pt	24	6	FSE	FSE	NNP
cord-104162-fe51v2pt	24	7	)	)	-RRB-
cord-104162-fe51v2pt	24	8	that	that	WDT
cord-104162-fe51v2pt	24	9	is	be	VBZ
cord-104162-fe51v2pt	24	10	among	among	IN
cord-104162-fe51v2pt	24	11	our	-PRON-	PRP$
cord-104162-fe51v2pt	24	12	results	result	NNS
cord-104162-fe51v2pt	24	13	,	,	,
cord-104162-fe51v2pt	24	14	is	be	VBZ
cord-104162-fe51v2pt	24	15	attracting	attract	VBG
cord-104162-fe51v2pt	24	16	attention	attention	NN
cord-104162-fe51v2pt	24	17	[	[	-LRB-
cord-104162-fe51v2pt	24	18	10	10	CD
cord-104162-fe51v2pt	24	19	,	,	,
cord-104162-fe51v2pt	24	20	13	13	CD
cord-104162-fe51v2pt	24	21	,	,	,
cord-104162-fe51v2pt	24	22	14	14	CD
cord-104162-fe51v2pt	24	23	]	]	-RRB-
cord-104162-fe51v2pt	24	24	.	.	.
cord-104162-fe51v2pt	25	1	Yet	yet	CC
cord-104162-fe51v2pt	25	2	our	-PRON-	PRP$
cord-104162-fe51v2pt	25	3	analysis	analysis	NN
cord-104162-fe51v2pt	25	4	,	,	,
cord-104162-fe51v2pt	25	5	consistent	consistent	JJ
cord-104162-fe51v2pt	25	6	with	with	IN
cord-104162-fe51v2pt	25	7	recent	recent	JJ
cord-104162-fe51v2pt	25	8	reports	report	NNS
cord-104162-fe51v2pt	25	9	[	[	-LRB-
cord-104162-fe51v2pt	25	10	15	15	CD
cord-104162-fe51v2pt	25	11	,	,	,
cord-104162-fe51v2pt	25	12	16	16	CD
cord-104162-fe51v2pt	25	13	]	]	-RRB-
cord-104162-fe51v2pt	25	14	,	,	,
cord-104162-fe51v2pt	25	15	suggests	suggest	VBZ
cord-104162-fe51v2pt	25	16	there	there	EX
cord-104162-fe51v2pt	25	17	may	may	MD
cord-104162-fe51v2pt	25	18	be	be	VB
cord-104162-fe51v2pt	25	19	more	more	RBR
cord-104162-fe51v2pt	25	20	suitable	suitable	JJ
cord-104162-fe51v2pt	25	21	targets	target	NNS
cord-104162-fe51v2pt	25	22	in	in	IN
cord-104162-fe51v2pt	25	23	other	other	JJ
cord-104162-fe51v2pt	25	24	regions	region	NNS
cord-104162-fe51v2pt	25	25	.	.	.
cord-104162-fe51v2pt	26	1	These	these	DT
cord-104162-fe51v2pt	26	2	were	be	VBD
cord-104162-fe51v2pt	26	3	obtained	obtain	VBN
cord-104162-fe51v2pt	26	4	from	from	IN
cord-104162-fe51v2pt	26	5	the	the	DT
cord-104162-fe51v2pt	26	6	NCBI	NCBI	NNP
cord-104162-fe51v2pt	26	7	(	(	-LRB-
cord-104162-fe51v2pt	26	8	Bethesda	Bethesda	NNP
cord-104162-fe51v2pt	26	9	)	)	-RRB-
cord-104162-fe51v2pt	26	10	and	and	CC
cord-104162-fe51v2pt	26	11	GISAID	GISAID	NNP
cord-104162-fe51v2pt	26	12	EpiCoV	EpiCoV	NNP
cord-104162-fe51v2pt	26	13	(	(	-LRB-
cord-104162-fe51v2pt	26	14	Munich	Munich	NNP
cord-104162-fe51v2pt	26	15	)	)	-RRB-
cord-104162-fe51v2pt	26	16	databases	database	NNS
cord-104162-fe51v2pt	26	17	.	.	.
cord-104162-fe51v2pt	27	1	The	the	DT
cord-104162-fe51v2pt	27	2	Wuhan	Wuhan	NNP
cord-104162-fe51v2pt	27	3	-	-	HYPH
cord-104162-fe51v2pt	27	4	Hu1	hu1	CD
cord-104162-fe51v2pt	27	5	sequence	sequence	NN
cord-104162-fe51v2pt	27	6	(	(	-LRB-
cord-104162-fe51v2pt	27	7	GenBank	GenBank	NNP
cord-104162-fe51v2pt	27	8	NC_045512.2	NC_045512.2	NNP
cord-104162-fe51v2pt	27	9	)	)	-RRB-
cord-104162-fe51v2pt	27	10	,	,	,
cord-104162-fe51v2pt	27	11	deemed	deem	VBD
cord-104162-fe51v2pt	27	12	taxonomically	taxonomically	RB
cord-104162-fe51v2pt	27	13	prototypic	prototypic	NNP
cord-104162-fe51v2pt	27	14	[	[	-LRB-
cord-104162-fe51v2pt	27	15	17	17	CD
cord-104162-fe51v2pt	27	16	,	,	,
cord-104162-fe51v2pt	27	17	18	18	CD
cord-104162-fe51v2pt	27	18	]	]	-RRB-
cord-104162-fe51v2pt	27	19	,	,	,
cord-104162-fe51v2pt	27	20	was	be	VBD
cord-104162-fe51v2pt	27	21	compared	compare	VBN
cord-104162-fe51v2pt	27	22	(	(	-LRB-
cord-104162-fe51v2pt	27	23	regarding	regard	VBG
cord-104162-fe51v2pt	27	24	base	base	NN
cord-104162-fe51v2pt	27	25	substitutions	substitution	NNS
cord-104162-fe51v2pt	27	26	and	and	CC
cord-104162-fe51v2pt	27	27	folding	fold	VBG
cord-104162-fe51v2pt	27	28	potential	potential	NN
cord-104162-fe51v2pt	27	29	)	)	-RRB-
cord-104162-fe51v2pt	27	30	with	with	IN
cord-104162-fe51v2pt	27	31	381	381	CD
cord-104162-fe51v2pt	27	32	Chinese	chinese	JJ
cord-104162-fe51v2pt	27	33	isolates	isolate	NNS
cord-104162-fe51v2pt	27	34	,	,	,
cord-104162-fe51v2pt	27	35	430	430	CD
cord-104162-fe51v2pt	27	36	Italian	italian	JJ
cord-104162-fe51v2pt	27	37	isolates	isolate	NNS
cord-104162-fe51v2pt	27	38	,	,	,
cord-104162-fe51v2pt	27	39	and	and	CC
cord-104162-fe51v2pt	27	40	932	932	CD
cord-104162-fe51v2pt	27	41	isolates	isolate	NNS
cord-104162-fe51v2pt	27	42	from	from	IN
cord-104162-fe51v2pt	27	43	New	New	NNP
cord-104162-fe51v2pt	27	44	York	York	NNP
cord-104162-fe51v2pt	27	45	,	,	,
cord-104162-fe51v2pt	27	46	USA	USA	NNP
cord-104162-fe51v2pt	27	47	.	.	.
cord-104162-fe51v2pt	28	1	Our	-PRON-	PRP$
cord-104162-fe51v2pt	28	2	"	"	``
cord-104162-fe51v2pt	28	3	window	window	NN
cord-104162-fe51v2pt	28	4	"	"	''
cord-104162-fe51v2pt	28	5	starting	starting	NN
cord-104162-fe51v2pt	28	6	point	point	NN
cord-104162-fe51v2pt	28	7	was	be	VBD
cord-104162-fe51v2pt	28	8	base	base	NN
cord-104162-fe51v2pt	28	9	1	1	CD
cord-104162-fe51v2pt	28	10	of	of	IN
cord-104162-fe51v2pt	28	11	the	the	DT
cord-104162-fe51v2pt	28	12	29,903	29,903	CD
cord-104162-fe51v2pt	28	13	base	base	NN
cord-104162-fe51v2pt	28	14	prototype	prototype	NN
cord-104162-fe51v2pt	28	15	sequence	sequence	NN
cord-104162-fe51v2pt	28	16	.	.	.
cord-104162-fe51v2pt	29	1	We	-PRON-	PRP
cord-104162-fe51v2pt	29	2	refer	refer	VBP
cord-104162-fe51v2pt	29	3	to	to	IN
cord-104162-fe51v2pt	29	4	windows	window	NNS
cord-104162-fe51v2pt	29	5	by	by	IN
cord-104162-fe51v2pt	29	6	their	-PRON-	PRP$
cord-104162-fe51v2pt	29	7	centers	center	NNS
cord-104162-fe51v2pt	29	8	.	.	.
cord-104162-fe51v2pt	30	1	The	the	DT
cord-104162-fe51v2pt	30	2	center	center	NN
cord-104162-fe51v2pt	30	3	of	of	IN
cord-104162-fe51v2pt	30	4	the	the	DT
cord-104162-fe51v2pt	30	5	first	first	JJ
cord-104162-fe51v2pt	30	6	200	200	CD
cord-104162-fe51v2pt	30	7	base	base	NN
cord-104162-fe51v2pt	30	8	window	window	NN
cord-104162-fe51v2pt	30	9	would	would	MD
cord-104162-fe51v2pt	30	10	be	be	VB
cord-104162-fe51v2pt	30	11	100	100	CD
cord-104162-fe51v2pt	30	12	.	.	.
cord-104162-fe51v2pt	31	1	In	in	IN
cord-104162-fe51v2pt	31	2	previous	previous	JJ
cord-104162-fe51v2pt	31	3	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	31	4	studies	study	NNS
cord-104162-fe51v2pt	31	5	the	the	DT
cord-104162-fe51v2pt	31	6	base	base	NN
cord-104162-fe51v2pt	31	7	differences	difference	NNS
cord-104162-fe51v2pt	31	8	between	between	IN
cord-104162-fe51v2pt	31	9	just	just	RB
cord-104162-fe51v2pt	31	10	two	two	CD
cord-104162-fe51v2pt	31	11	individual	individual	JJ
cord-104162-fe51v2pt	31	12	sequences	sequence	NNS
cord-104162-fe51v2pt	31	13	sufficed	suffice	VBD
cord-104162-fe51v2pt	31	14	for	for	IN
cord-104162-fe51v2pt	31	15	the	the	DT
cord-104162-fe51v2pt	31	16	tabulation	tabulation	NN
cord-104162-fe51v2pt	31	17	of	of	IN
cord-104162-fe51v2pt	31	18	a	a	DT
cord-104162-fe51v2pt	31	19	statistically	statistically	RB
cord-104162-fe51v2pt	31	20	significant	significant	JJ
cord-104162-fe51v2pt	31	21	set	set	NN
cord-104162-fe51v2pt	31	22	of	of	IN
cord-104162-fe51v2pt	31	23	base	base	NN
cord-104162-fe51v2pt	31	24	substitution	substitution	NN
cord-104162-fe51v2pt	31	25	frequencies	frequency	NNS
cord-104162-fe51v2pt	31	26	[	[	-LRB-
cord-104162-fe51v2pt	31	27	2	2	CD
cord-104162-fe51v2pt	31	28	]	]	-RRB-
cord-104162-fe51v2pt	31	29	.	.	.
cord-104162-fe51v2pt	32	1	4	4	LS
cord-104162-fe51v2pt	33	1	The	the	DT
cord-104162-fe51v2pt	33	2	lower	low	JJR
cord-104162-fe51v2pt	33	3	mutation	mutation	NN
cord-104162-fe51v2pt	33	4	rates	rate	NNS
cord-104162-fe51v2pt	33	5	of	of	IN
cord-104162-fe51v2pt	33	6	SARS	SARS	NNP
cord-104162-fe51v2pt	33	7	-	-	HYPH
cord-104162-fe51v2pt	33	8	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	33	9	strains	strain	NNS
cord-104162-fe51v2pt	33	10	[	[	-LRB-
cord-104162-fe51v2pt	33	11	11	11	CD
cord-104162-fe51v2pt	33	12	]	]	-RRB-
cord-104162-fe51v2pt	33	13	 	 	_SP
cord-104162-fe51v2pt	34	1	The	the	DT
cord-104162-fe51v2pt	34	2	energetics	energetic	NNS
cord-104162-fe51v2pt	34	3	of	of	IN
cord-104162-fe51v2pt	34	4	the	the	DT
cord-104162-fe51v2pt	34	5	folding	folding	NN
cord-104162-fe51v2pt	34	6	of	of	IN
cord-104162-fe51v2pt	34	7	a	a	DT
cord-104162-fe51v2pt	34	8	single	single	RB
cord-104162-fe51v2pt	34	9	-	-	HYPH
cord-104162-fe51v2pt	34	10	stranded	strand	VBN
cord-104162-fe51v2pt	34	11	nucleic	nucleic	JJ
cord-104162-fe51v2pt	34	12	acid	acid	NN
cord-104162-fe51v2pt	34	13	into	into	IN
cord-104162-fe51v2pt	34	14	a	a	DT
cord-104162-fe51v2pt	34	15	stem	stem	NN
cord-104162-fe51v2pt	34	16	-	-	HYPH
cord-104162-fe51v2pt	34	17	loop	loop	NN
cord-104162-fe51v2pt	34	18	structure	structure	NN
cord-104162-fe51v2pt	34	19	depend	depend	VBP
cord-104162-fe51v2pt	34	20	on	on	IN
cord-104162-fe51v2pt	34	21	both	both	CC
cord-104162-fe51v2pt	34	22	the	the	DT
cord-104162-fe51v2pt	34	23	composition	composition	NN
cord-104162-fe51v2pt	34	24	and	and	CC
cord-104162-fe51v2pt	34	25	order	order	NN
cord-104162-fe51v2pt	34	26	of	of	IN
cord-104162-fe51v2pt	34	27	its	-PRON-	PRP$
cord-104162-fe51v2pt	34	28	bases	basis	NNS
cord-104162-fe51v2pt	34	29	.	.	.
cord-104162-fe51v2pt	35	1	Base	base	NN
cord-104162-fe51v2pt	35	2	composition	composition	NN
cord-104162-fe51v2pt	35	3	is	be	VBZ
cord-104162-fe51v2pt	35	4	a	a	DT
cord-104162-fe51v2pt	35	5	distinctive	distinctive	JJ
cord-104162-fe51v2pt	35	6	characteristic	characteristic	NN
cord-104162-fe51v2pt	35	7	of	of	IN
cord-104162-fe51v2pt	35	8	a	a	DT
cord-104162-fe51v2pt	35	9	genome	genome	NN
cord-104162-fe51v2pt	35	10	or	or	CC
cord-104162-fe51v2pt	35	11	large	large	JJ
cord-104162-fe51v2pt	35	12	genome	genome	NN
cord-104162-fe51v2pt	35	13	sector	sector	NN
cord-104162-fe51v2pt	35	14	.	.	.
cord-104162-fe51v2pt	36	1	A	a	DT
cord-104162-fe51v2pt	36	2	localized	localized	JJ
cord-104162-fe51v2pt	36	3	sequence	sequence	NN
cord-104162-fe51v2pt	36	4	(	(	-LRB-
cord-104162-fe51v2pt	36	5	e.g.	e.g.	IN
cord-104162-fe51v2pt	36	6	a	a	DT
cord-104162-fe51v2pt	36	7	200	200	CD
cord-104162-fe51v2pt	36	8	base	base	NN
cord-104162-fe51v2pt	36	9	window	window	NN
cord-104162-fe51v2pt	36	10	)	)	-RRB-
cord-104162-fe51v2pt	36	11	,	,	,
cord-104162-fe51v2pt	36	12	which	which	WDT
cord-104162-fe51v2pt	36	13	is	be	VBZ
cord-104162-fe51v2pt	36	14	rich	rich	JJ
cord-104162-fe51v2pt	36	15	in	in	IN
cord-104162-fe51v2pt	36	16	the	the	DT
cord-104162-fe51v2pt	36	17	strongly	strongly	RB
cord-104162-fe51v2pt	36	18	-	-	HYPH
cord-104162-fe51v2pt	36	19	pairing	pair	VBG
cord-104162-fe51v2pt	36	20	bases	basis	NNS
cord-104162-fe51v2pt	36	21	G	g	NN
cord-104162-fe51v2pt	36	22	and	and	CC
cord-104162-fe51v2pt	36	23	C	C	NNP
cord-104162-fe51v2pt	36	24	,	,	,
cord-104162-fe51v2pt	36	25	will	will	MD
cord-104162-fe51v2pt	36	26	tend	tend	VB
cord-104162-fe51v2pt	36	27	to	to	TO
cord-104162-fe51v2pt	36	28	have	have	VB
cord-104162-fe51v2pt	36	29	a	a	DT
cord-104162-fe51v2pt	36	30	stable	stable	JJ
cord-104162-fe51v2pt	36	31	structure	structure	NN
cord-104162-fe51v2pt	36	32	simply	simply	RB
cord-104162-fe51v2pt	36	33	by	by	IN
cord-104162-fe51v2pt	36	34	virtue	virtue	NN
cord-104162-fe51v2pt	36	35	of	of	IN
cord-104162-fe51v2pt	36	36	its	-PRON-	PRP$
cord-104162-fe51v2pt	36	37	base	base	NN
cord-104162-fe51v2pt	36	38	composition	composition	NN
cord-104162-fe51v2pt	36	39	,	,	,
cord-104162-fe51v2pt	36	40	rather	rather	RB
cord-104162-fe51v2pt	36	41	than	than	IN
cord-104162-fe51v2pt	36	42	of	of	IN
cord-104162-fe51v2pt	36	43	its	-PRON-	PRP$
cord-104162-fe51v2pt	36	44	unique	unique	JJ
cord-104162-fe51v2pt	36	45	base	base	NN
cord-104162-fe51v2pt	36	46	order	order	NN
cord-104162-fe51v2pt	36	47	.	.	.
cord-104162-fe51v2pt	37	1	This	this	DT
cord-104162-fe51v2pt	37	2	high	high	JJ
cord-104162-fe51v2pt	37	3	GC%	GC%	NNP
cord-104162-fe51v2pt	37	4	value	value	NN
cord-104162-fe51v2pt	37	5	can	can	MD
cord-104162-fe51v2pt	37	6	obscure	obscure	VB
cord-104162-fe51v2pt	37	7	the	the	DT
cord-104162-fe51v2pt	37	8	contribution	contribution	NN
cord-104162-fe51v2pt	37	9	of	of	IN
cord-104162-fe51v2pt	37	10	the	the	DT
cord-104162-fe51v2pt	37	11	base	base	NN
cord-104162-fe51v2pt	37	12	order	order	NN
cord-104162-fe51v2pt	37	13	-	-	HYPH
cord-104162-fe51v2pt	37	14	dependent	dependent	JJ
cord-104162-fe51v2pt	37	15	component	component	NN
cord-104162-fe51v2pt	37	16	of	of	IN
cord-104162-fe51v2pt	37	17	the	the	DT
cord-104162-fe51v2pt	37	18	folding	folding	NN
cord-104162-fe51v2pt	37	19	energy	energy	NN
cord-104162-fe51v2pt	37	20	,	,	,
cord-104162-fe51v2pt	37	21	which	which	WDT
cord-104162-fe51v2pt	37	22	provides	provide	VBZ
cord-104162-fe51v2pt	37	23	a	a	DT
cord-104162-fe51v2pt	37	24	sensitive	sensitive	JJ
cord-104162-fe51v2pt	37	25	indicator	indicator	NN
cord-104162-fe51v2pt	37	26	of	of	IN
cord-104162-fe51v2pt	37	27	local	local	JJ
cord-104162-fe51v2pt	37	28	intraspecies	intraspecie	NNS
cord-104162-fe51v2pt	37	29	pressures	pressure	NNS
cord-104162-fe51v2pt	37	30	for	for	IN
cord-104162-fe51v2pt	37	31	the	the	DT
cord-104162-fe51v2pt	37	32	conservation	conservation	NN
cord-104162-fe51v2pt	37	33	of	of	IN
cord-104162-fe51v2pt	37	34	function	function	NN
cord-104162-fe51v2pt	37	35	within	within	IN
cord-104162-fe51v2pt	37	36	a	a	DT
cord-104162-fe51v2pt	37	37	population	population	NN
cord-104162-fe51v2pt	37	38	(	(	-LRB-
cord-104162-fe51v2pt	37	39	i.e.	i.e.	FW
cord-104162-fe51v2pt	37	40	a	a	DT
cord-104162-fe51v2pt	37	41	mutated	mutate	VBN
cord-104162-fe51v2pt	37	42	organism	organism	NN
cord-104162-fe51v2pt	37	43	is	be	VBZ
cord-104162-fe51v2pt	37	44	eliminated	eliminate	VBN
cord-104162-fe51v2pt	37	45	by	by	IN
cord-104162-fe51v2pt	37	46	natural	natural	JJ
cord-104162-fe51v2pt	37	47	selection	selection	NN
cord-104162-fe51v2pt	37	48	so	so	IN
cord-104162-fe51v2pt	37	49	no	no	RB
cord-104162-fe51v2pt	37	50	longer	long	RBR
cord-104162-fe51v2pt	37	51	can	can	MD
cord-104162-fe51v2pt	37	52	be	be	VB
cord-104162-fe51v2pt	37	53	assayed	assay	VBN
cord-104162-fe51v2pt	37	54	for	for	IN
cord-104162-fe51v2pt	37	55	function	function	NN
cord-104162-fe51v2pt	37	56	in	in	IN
cord-104162-fe51v2pt	37	57	the	the	DT
cord-104162-fe51v2pt	37	58	population	population	NN
cord-104162-fe51v2pt	37	59	)	)	-RRB-
cord-104162-fe51v2pt	37	60	.	.	.
cord-104162-fe51v2pt	38	1	In	in	IN
cord-104162-fe51v2pt	38	2	contrast	contrast	NN
cord-104162-fe51v2pt	38	3	,	,	,
cord-104162-fe51v2pt	38	4	interspecies	interspecie	NNS
cord-104162-fe51v2pt	38	5	mutations	mutation	NNS
cord-104162-fe51v2pt	38	6	tend	tend	VBP
cord-104162-fe51v2pt	38	7	to	to	TO
cord-104162-fe51v2pt	38	8	influence	influence	VB
cord-104162-fe51v2pt	38	9	the	the	DT
cord-104162-fe51v2pt	38	10	genome	genome	NN
cord-104162-fe51v2pt	38	11	-	-	HYPH
cord-104162-fe51v2pt	38	12	wide	wide	JJ
cord-104162-fe51v2pt	38	13	oligonucleotide	oligonucleotide	NN
cord-104162-fe51v2pt	38	14	(	(	-LRB-
cord-104162-fe51v2pt	38	15	k	k	NNP
cord-104162-fe51v2pt	38	16	-	-	HYPH
cord-104162-fe51v2pt	38	17	mer	mer	NNP
cord-104162-fe51v2pt	38	18	)	)	-RRB-
cord-104162-fe51v2pt	38	19	pressure	pressure	NN
cord-104162-fe51v2pt	38	20	,	,	,
cord-104162-fe51v2pt	38	21	of	of	IN
cord-104162-fe51v2pt	38	22	which	which	WDT
cord-104162-fe51v2pt	38	23	base	base	NN
cord-104162-fe51v2pt	38	24	composition	composition	NN
cord-104162-fe51v2pt	38	25	(	(	-LRB-
cord-104162-fe51v2pt	38	26	GC%	GC%	NNP
cord-104162-fe51v2pt	38	27	)	)	-RRB-
cord-104162-fe51v2pt	38	28	is	be	VBZ
cord-104162-fe51v2pt	38	29	an	an	DT
cord-104162-fe51v2pt	38	30	indicator	indicator	NN
cord-104162-fe51v2pt	38	31	.	.	.
cord-104162-fe51v2pt	39	1	This	this	DT
cord-104162-fe51v2pt	39	2	pressure	pressure	NN
cord-104162-fe51v2pt	39	3	can	can	MD
cord-104162-fe51v2pt	39	4	act	act	VB
cord-104162-fe51v2pt	39	5	to	to	TO
cord-104162-fe51v2pt	39	6	generate	generate	VB
cord-104162-fe51v2pt	39	7	and/or	and/or	CC
cord-104162-fe51v2pt	39	8	sustain	sustain	VB
cord-104162-fe51v2pt	39	9	members	member	NNS
cord-104162-fe51v2pt	39	10	of	of	IN
cord-104162-fe51v2pt	39	11	emerging	emerge	VBG
cord-104162-fe51v2pt	39	12	species	specie	NNS
cord-104162-fe51v2pt	39	13	by	by	IN
cord-104162-fe51v2pt	39	14	preventing	prevent	VBG
cord-104162-fe51v2pt	39	15	recombination	recombination	NN
cord-104162-fe51v2pt	39	16	with	with	IN
cord-104162-fe51v2pt	39	17	parental	parental	JJ
cord-104162-fe51v2pt	39	18	forms	form	NNS
cord-104162-fe51v2pt	39	19	[	[	-LRB-
cord-104162-fe51v2pt	39	20	3	3	CD
cord-104162-fe51v2pt	39	21	,	,	,
cord-104162-fe51v2pt	39	22	7	7	CD
cord-104162-fe51v2pt	39	23	,	,	,
cord-104162-fe51v2pt	39	24	[	[	-LRB-
cord-104162-fe51v2pt	39	25	19	19	CD
cord-104162-fe51v2pt	39	26	]	]	-RRB-
cord-104162-fe51v2pt	39	27	[	[	-LRB-
cord-104162-fe51v2pt	39	28	20	20	CD
cord-104162-fe51v2pt	39	29	]	]	-RRB-
cord-104162-fe51v2pt	39	30	[	[	-LRB-
cord-104162-fe51v2pt	39	31	21	21	CD
cord-104162-fe51v2pt	39	32	]	]	-RRB-
cord-104162-fe51v2pt	39	33	.	.	.
cord-104162-fe51v2pt	40	1	Elimination	elimination	NN
cord-104162-fe51v2pt	40	2	of	of	IN
cord-104162-fe51v2pt	40	3	this	this	DT
cord-104162-fe51v2pt	40	4	base	base	NN
cord-104162-fe51v2pt	40	5	composition	composition	NN
cord-104162-fe51v2pt	40	6	-	-	HYPH
cord-104162-fe51v2pt	40	7	dependent	dependent	JJ
cord-104162-fe51v2pt	40	8	component	component	NN
cord-104162-fe51v2pt	40	9	facilitates	facilitate	VBZ
cord-104162-fe51v2pt	40	10	focus	focus	NN
cord-104162-fe51v2pt	40	11	on	on	IN
cord-104162-fe51v2pt	40	12	local	local	JJ
cord-104162-fe51v2pt	40	13	folding	folding	NN
cord-104162-fe51v2pt	40	14	.	.	.
cord-104162-fe51v2pt	41	1	5	5	LS
cord-104162-fe51v2pt	42	1	Early	early	JJ
cord-104162-fe51v2pt	42	2	studies	study	NNS
cord-104162-fe51v2pt	42	3	of	of	IN
cord-104162-fe51v2pt	42	4	RNA	RNA	NNP
cord-104162-fe51v2pt	42	5	virus	virus	NN
cord-104162-fe51v2pt	42	6	structure	structure	NN
cord-104162-fe51v2pt	42	7	by	by	IN
cord-104162-fe51v2pt	42	8	Le	Le	NNP
cord-104162-fe51v2pt	42	9	and	and	CC
cord-104162-fe51v2pt	42	10	Maizel	Maizel	NNP
cord-104162-fe51v2pt	43	1	[	[	-LRB-
cord-104162-fe51v2pt	43	2	22	22	CD
cord-104162-fe51v2pt	43	3	]	]	-RRB-
cord-104162-fe51v2pt	43	4	were	be	VBD
cord-104162-fe51v2pt	43	5	primarily	primarily	RB
cord-104162-fe51v2pt	43	6	concerned	concern	VBN
cord-104162-fe51v2pt	43	7	with	with	IN
cord-104162-fe51v2pt	43	8	the	the	DT
cord-104162-fe51v2pt	43	9	statistical	statistical	JJ
cord-104162-fe51v2pt	43	10	significance	significance	NN
cord-104162-fe51v2pt	43	11	of	of	IN
cord-104162-fe51v2pt	43	12	RNA	RNA	NNP
cord-104162-fe51v2pt	43	13	folding	folding	NN
cord-104162-fe51v2pt	43	14	,	,	,
cord-104162-fe51v2pt	43	15	rather	rather	RB
cord-104162-fe51v2pt	43	16	than	than	IN
cord-104162-fe51v2pt	43	17	with	with	IN
cord-104162-fe51v2pt	43	18	distinguishing	distinguish	VBG
cord-104162-fe51v2pt	43	19	the	the	DT
cord-104162-fe51v2pt	43	20	relative	relative	JJ
cord-104162-fe51v2pt	43	21	contributions	contribution	NNS
cord-104162-fe51v2pt	43	22	of	of	IN
cord-104162-fe51v2pt	43	23	base	base	NN
cord-104162-fe51v2pt	43	24	composition	composition	NN
cord-104162-fe51v2pt	43	25	and	and	CC
cord-104162-fe51v2pt	43	26	base	base	NN
cord-104162-fe51v2pt	43	27	order	order	NN
cord-104162-fe51v2pt	43	28	.	.	.
cord-104162-fe51v2pt	44	1	However	however	RB
cord-104162-fe51v2pt	44	2	,	,	,
cord-104162-fe51v2pt	44	3	with	with	IN
cord-104162-fe51v2pt	44	4	a	a	DT
cord-104162-fe51v2pt	44	5	pipeline	pipeline	NN
cord-104162-fe51v2pt	44	6	between	between	IN
cord-104162-fe51v2pt	44	7	the	the	DT
cord-104162-fe51v2pt	44	8	various	various	JJ
cord-104162-fe51v2pt	44	9	programs	program	NNS
cord-104162-fe51v2pt	44	10	that	that	WDT
cord-104162-fe51v2pt	44	11	were	be	VBD
cord-104162-fe51v2pt	44	12	offered	offer	VBN
cord-104162-fe51v2pt	44	13	by	by	IN
cord-104162-fe51v2pt	44	14	the	the	DT
cord-104162-fe51v2pt	44	15	Wisconsin	Wisconsin	NNP
cord-104162-fe51v2pt	44	16	Genetics	Genetics	NNP
cord-104162-fe51v2pt	44	17	Computer	Computer	NNP
cord-104162-fe51v2pt	44	18	Group	Group	NNP
cord-104162-fe51v2pt	44	19	,	,	,
cord-104162-fe51v2pt	44	20	the	the	DT
cord-104162-fe51v2pt	44	21	base	base	NN
cord-104162-fe51v2pt	44	22	composition	composition	NN
cord-104162-fe51v2pt	44	23	and	and	CC
cord-104162-fe51v2pt	44	24	base	base	NN
cord-104162-fe51v2pt	44	25	order	order	NN
cord-104162-fe51v2pt	44	26	-	-	HYPH
cord-104162-fe51v2pt	44	27	dependent	dependent	JJ
cord-104162-fe51v2pt	44	28	components	component	NNS
cord-104162-fe51v2pt	44	29	were	be	VBD
cord-104162-fe51v2pt	44	30	separated	separate	VBN
cord-104162-fe51v2pt	44	31	and	and	CC
cord-104162-fe51v2pt	44	32	individually	individually	RB
cord-104162-fe51v2pt	44	33	assessed	assess	VBN
cord-104162-fe51v2pt	44	34	(	(	-LRB-
cord-104162-fe51v2pt	44	35	"	"	``
cord-104162-fe51v2pt	44	36	folding	folding	NN
cord-104162-fe51v2pt	44	37	of	of	IN
cord-104162-fe51v2pt	44	38	randomized	randomized	JJ
cord-104162-fe51v2pt	44	39	sequence	sequence	NN
cord-104162-fe51v2pt	44	40	difference	difference	NN
cord-104162-fe51v2pt	44	41	"	"	''
cord-104162-fe51v2pt	44	42	analysis	analysis	NN
cord-104162-fe51v2pt	44	43	;	;	:
cord-104162-fe51v2pt	44	44	FORS	FORS	NNP
cord-104162-fe51v2pt	44	45	-	-	HYPH
cord-104162-fe51v2pt	44	46	D	d	NN
cord-104162-fe51v2pt	44	47	analysis	analysis	NN
cord-104162-fe51v2pt	44	48	)	)	-RRB-
cord-104162-fe51v2pt	44	49	.	.	.
cord-104162-fe51v2pt	45	1	Departing	depart	VBG
cord-104162-fe51v2pt	45	2	from	from	IN
cord-104162-fe51v2pt	45	3	Le	Le	NNP
cord-104162-fe51v2pt	45	4	and	and	CC
cord-104162-fe51v2pt	45	5	Maizel	Maizel	NNP
cord-104162-fe51v2pt	45	6	,	,	,
cord-104162-fe51v2pt	45	7	FORS	FORS	NNP
cord-104162-fe51v2pt	45	8	-	-	HYPH
cord-104162-fe51v2pt	45	9	D	d	JJ
cord-104162-fe51v2pt	45	10	values	value	NNS
cord-104162-fe51v2pt	45	11	(	(	-LRB-
cord-104162-fe51v2pt	45	12	see	see	VB
cord-104162-fe51v2pt	45	13	below	below	RB
cord-104162-fe51v2pt	45	14	)	)	-RRB-
cord-104162-fe51v2pt	45	15	were	be	VBD
cord-104162-fe51v2pt	45	16	not	not	RB
cord-104162-fe51v2pt	45	17	divided	divide	VBN
cord-104162-fe51v2pt	45	18	to	to	TO
cord-104162-fe51v2pt	45	19	yield	yield	VB
cord-104162-fe51v2pt	45	20	Z	z	NN
cord-104162-fe51v2pt	45	21	-	-	HYPH
cord-104162-fe51v2pt	45	22	scores	score	NNS
cord-104162-fe51v2pt	45	23	,	,	,
cord-104162-fe51v2pt	45	24	but	but	CC
cord-104162-fe51v2pt	45	25	were	be	VBD
cord-104162-fe51v2pt	45	26	simply	simply	RB
cord-104162-fe51v2pt	45	27	plotted	plot	VBN
cord-104162-fe51v2pt	45	28	with	with	IN
cord-104162-fe51v2pt	45	29	statistical	statistical	JJ
cord-104162-fe51v2pt	45	30	error	error	NN
cord-104162-fe51v2pt	45	31	bars	bar	NNS
cord-104162-fe51v2pt	45	32	[	[	-LRB-
cord-104162-fe51v2pt	45	33	2	2	CD
cord-104162-fe51v2pt	45	34	,	,	,
cord-104162-fe51v2pt	45	35	3	3	CD
cord-104162-fe51v2pt	45	36	,	,	,
cord-104162-fe51v2pt	45	37	7	7	CD
cord-104162-fe51v2pt	45	38	,	,	,
cord-104162-fe51v2pt	45	39	23	23	CD
cord-104162-fe51v2pt	45	40	,	,	,
cord-104162-fe51v2pt	45	41	24	24	CD
cord-104162-fe51v2pt	45	42	]	]	-RRB-
cord-104162-fe51v2pt	45	43	.	.	.
cord-104162-fe51v2pt	46	1	The	the	DT
cord-104162-fe51v2pt	46	2	limits	limit	NNS
cord-104162-fe51v2pt	46	3	of	of	IN
cord-104162-fe51v2pt	46	4	the	the	DT
cord-104162-fe51v2pt	46	5	latter	latter	JJ
cord-104162-fe51v2pt	46	6	were	be	VBD
cord-104162-fe51v2pt	46	7	generally	generally	RB
cord-104162-fe51v2pt	46	8	close	close	JJ
cord-104162-fe51v2pt	46	9	to	to	IN
cord-104162-fe51v2pt	46	10	the	the	DT
cord-104162-fe51v2pt	46	11	corresponding	correspond	VBG
cord-104162-fe51v2pt	46	12	FORS	FORS	NNP
cord-104162-fe51v2pt	46	13	-	-	HYPH
cord-104162-fe51v2pt	46	14	D	d	JJ
cord-104162-fe51v2pt	46	15	values	value	NNS
cord-104162-fe51v2pt	46	16	and	and	CC
cord-104162-fe51v2pt	46	17	,	,	,
cord-104162-fe51v2pt	46	18	for	for	IN
cord-104162-fe51v2pt	46	19	clarity	clarity	NN
cord-104162-fe51v2pt	46	20	,	,	,
cord-104162-fe51v2pt	46	21	are	be	VBP
cord-104162-fe51v2pt	46	22	omitted	omit	VBN
cord-104162-fe51v2pt	46	23	here	here	RB
cord-104162-fe51v2pt	46	24	.	.	.
cord-104162-fe51v2pt	47	1	A	a	DT
cord-104162-fe51v2pt	47	2	window	window	NN
cord-104162-fe51v2pt	47	3	of	of	IN
cord-104162-fe51v2pt	47	4	200	200	CD
cord-104162-fe51v2pt	47	5	bases	basis	NNS
cord-104162-fe51v2pt	47	6	is	be	VBZ
cord-104162-fe51v2pt	47	7	moved	move	VBN
cord-104162-fe51v2pt	47	8	along	along	IN
cord-104162-fe51v2pt	47	9	a	a	DT
cord-104162-fe51v2pt	47	10	natural	natural	JJ
cord-104162-fe51v2pt	47	11	sequence	sequence	NN
cord-104162-fe51v2pt	47	12	in	in	IN
cord-104162-fe51v2pt	47	13	20	20	CD
cord-104162-fe51v2pt	47	14	or	or	CC
cord-104162-fe51v2pt	47	15	50	50	CD
cord-104162-fe51v2pt	47	16	base	base	NN
cord-104162-fe51v2pt	47	17	steps	step	NNS
cord-104162-fe51v2pt	47	18	.	.	.
cord-104162-fe51v2pt	48	1	A	a	DT
cord-104162-fe51v2pt	48	2	folding	folding	NN
cord-104162-fe51v2pt	48	3	program	program	NN
cord-104162-fe51v2pt	48	4	[	[	-LRB-
cord-104162-fe51v2pt	48	5	25	25	CD
cord-104162-fe51v2pt	48	6	]	]	-RRB-
cord-104162-fe51v2pt	48	7	is	be	VBZ
cord-104162-fe51v2pt	48	8	applied	apply	VBN
cord-104162-fe51v2pt	48	9	to	to	IN
cord-104162-fe51v2pt	48	10	the	the	DT
cord-104162-fe51v2pt	48	11	sequence	sequence	NN
cord-104162-fe51v2pt	48	12	in	in	IN
cord-104162-fe51v2pt	48	13	each	each	DT
cord-104162-fe51v2pt	48	14	window	window	NN
cord-104162-fe51v2pt	48	15	to	to	TO
cord-104162-fe51v2pt	48	16	obtain	obtain	VB
cord-104162-fe51v2pt	48	17	"	"	``
cord-104162-fe51v2pt	48	18	folding	folding	NN
cord-104162-fe51v2pt	48	19	of	of	IN
cord-104162-fe51v2pt	48	20	natural	natural	JJ
cord-104162-fe51v2pt	48	21	sequence	sequence	NN
cord-104162-fe51v2pt	48	22	"	"	''
cord-104162-fe51v2pt	48	23	(	(	-LRB-
cord-104162-fe51v2pt	48	24	FONS	FONS	NNP
cord-104162-fe51v2pt	48	25	)	)	-RRB-
cord-104162-fe51v2pt	48	26	values	value	NNS
cord-104162-fe51v2pt	48	27	for	for	IN
cord-104162-fe51v2pt	48	28	each	each	DT
cord-104162-fe51v2pt	48	29	window	window	NN
cord-104162-fe51v2pt	48	30	,	,	,
cord-104162-fe51v2pt	48	31	to	to	IN
cord-104162-fe51v2pt	48	32	which	which	WDT
cord-104162-fe51v2pt	48	33	both	both	DT
cord-104162-fe51v2pt	48	34	base	base	NN
cord-104162-fe51v2pt	48	35	composition	composition	NN
cord-104162-fe51v2pt	48	36	and	and	CC
cord-104162-fe51v2pt	48	37	base	base	NN
cord-104162-fe51v2pt	48	38	order	order	NN
cord-104162-fe51v2pt	48	39	will	will	MD
cord-104162-fe51v2pt	48	40	have	have	VB
cord-104162-fe51v2pt	48	41	contributed	contribute	VBN
cord-104162-fe51v2pt	48	42	.	.	.
cord-104162-fe51v2pt	49	1	The	the	DT
cord-104162-fe51v2pt	49	2	four	four	CD
cord-104162-fe51v2pt	49	3	bases	basis	NNS
cord-104162-fe51v2pt	49	4	in	in	IN
cord-104162-fe51v2pt	49	5	each	each	DT
cord-104162-fe51v2pt	49	6	sequence	sequence	NN
cord-104162-fe51v2pt	49	7	window	window	NN
cord-104162-fe51v2pt	49	8	are	be	VBP
cord-104162-fe51v2pt	49	9	then	then	RB
cord-104162-fe51v2pt	49	10	shuffled	shuffle	VBN
cord-104162-fe51v2pt	49	11	to	to	TO
cord-104162-fe51v2pt	49	12	destroy	destroy	VB
cord-104162-fe51v2pt	49	13	their	-PRON-	PRP$
cord-104162-fe51v2pt	49	14	order	order	NN
cord-104162-fe51v2pt	49	15	while	while	IN
cord-104162-fe51v2pt	49	16	retaining	retain	VBG
cord-104162-fe51v2pt	49	17	base	base	NN
cord-104162-fe51v2pt	49	18	composition	composition	NN
cord-104162-fe51v2pt	49	19	,	,	,
cord-104162-fe51v2pt	49	20	and	and	CC
cord-104162-fe51v2pt	49	21	folding	fold	VBG
cord-104162-fe51v2pt	49	22	energy	energy	NN
cord-104162-fe51v2pt	49	23	is	be	VBZ
cord-104162-fe51v2pt	49	24	again	again	RB
cord-104162-fe51v2pt	49	25	determined	determined	JJ
cord-104162-fe51v2pt	49	26	.	.	.
cord-104162-fe51v2pt	50	1	This	this	DT
cord-104162-fe51v2pt	50	2	shuffle	shuffle	NN
cord-104162-fe51v2pt	50	3	-	-	HYPH
cord-104162-fe51v2pt	50	4	and	and	CC
cord-104162-fe51v2pt	50	5	-	-	HYPH
cord-104162-fe51v2pt	50	6	fold	fold	VB
cord-104162-fe51v2pt	50	7	"	"	''
cord-104162-fe51v2pt	50	8	Monte	Monte	NNP
cord-104162-fe51v2pt	50	9	Carlo	Carlo	NNP
cord-104162-fe51v2pt	50	10	"	"	''
cord-104162-fe51v2pt	50	11	procedure	procedure	NN
cord-104162-fe51v2pt	50	12	is	be	VBZ
cord-104162-fe51v2pt	50	13	repeated	repeat	VBN
cord-104162-fe51v2pt	50	14	ten	ten	CD
cord-104162-fe51v2pt	50	15	times	time	NNS
cord-104162-fe51v2pt	50	16	and	and	CC
cord-104162-fe51v2pt	50	17	the	the	DT
cord-104162-fe51v2pt	50	18	average	average	JJ
cord-104162-fe51v2pt	50	19	(	(	-LRB-
cord-104162-fe51v2pt	50	20	mean	mean	VB
cord-104162-fe51v2pt	50	21	)	)	-RRB-
cord-104162-fe51v2pt	50	22	folding	folding	NN
cord-104162-fe51v2pt	50	23	value	value	NN
cord-104162-fe51v2pt	50	24	is	be	VBZ
cord-104162-fe51v2pt	50	25	taken	take	VBN
cord-104162-fe51v2pt	50	26	as	as	IN
cord-104162-fe51v2pt	50	27	 	 	_SP
cord-104162-fe51v2pt	51	1	The	the	DT
cord-104162-fe51v2pt	51	2	approach	approach	NN
cord-104162-fe51v2pt	51	3	was	be	VBD
cord-104162-fe51v2pt	51	4	employed	employ	VBN
cord-104162-fe51v2pt	51	5	by	by	IN
cord-104162-fe51v2pt	51	6	others	other	NNS
cord-104162-fe51v2pt	51	7	who	who	WP
cord-104162-fe51v2pt	51	8	,	,	,
cord-104162-fe51v2pt	51	9	rather	rather	RB
cord-104162-fe51v2pt	51	10	than	than	IN
cord-104162-fe51v2pt	51	11	shuffling	shuffle	VBG
cord-104162-fe51v2pt	51	12	the	the	DT
cord-104162-fe51v2pt	51	13	four	four	CD
cord-104162-fe51v2pt	51	14	bases	basis	NNS
cord-104162-fe51v2pt	51	15	,	,	,
cord-104162-fe51v2pt	51	16	favored	favor	VBD
cord-104162-fe51v2pt	51	17	retaining	retain	VBG
cord-104162-fe51v2pt	51	18	some	some	DT
cord-104162-fe51v2pt	51	19	base	base	NN
cord-104162-fe51v2pt	51	20	order	order	NN
cord-104162-fe51v2pt	51	21	information	information	NN
cord-104162-fe51v2pt	51	22	.	.	.
cord-104162-fe51v2pt	52	1	Accordingly	accordingly	RB
cord-104162-fe51v2pt	52	2	,	,	,
cord-104162-fe51v2pt	52	3	they	-PRON-	PRP
cord-104162-fe51v2pt	52	4	shuffled	shuffle	VBD
cord-104162-fe51v2pt	52	5	groups	group	NNS
cord-104162-fe51v2pt	52	6	of	of	IN
cord-104162-fe51v2pt	52	7	bases	basis	NNS
cord-104162-fe51v2pt	52	8	(	(	-LRB-
cord-104162-fe51v2pt	52	9	e.g.	e.g.	IN
cord-104162-fe51v2pt	52	10	the	the	DT
cord-104162-fe51v2pt	52	11	sixteen	sixteen	CD
cord-104162-fe51v2pt	52	12	dinucleotides	dinucleotide	NNS
cord-104162-fe51v2pt	52	13	)	)	-RRB-
cord-104162-fe51v2pt	52	14	.	.	.
cord-104162-fe51v2pt	53	1	Following	follow	VBG
cord-104162-fe51v2pt	53	2	disparagement	disparagement	NN
cord-104162-fe51v2pt	53	3	of	of	IN
cord-104162-fe51v2pt	53	4	the	the	DT
cord-104162-fe51v2pt	53	5	conceptual	conceptual	JJ
cord-104162-fe51v2pt	53	6	basis	basis	NN
cord-104162-fe51v2pt	53	7	of	of	IN
cord-104162-fe51v2pt	53	8	four	four	CD
cord-104162-fe51v2pt	53	9	base	base	NN
cord-104162-fe51v2pt	53	10	shuffling	shuffling	NN
cord-104162-fe51v2pt	53	11	,	,	,
cord-104162-fe51v2pt	53	12	which	which	WDT
cord-104162-fe51v2pt	53	13	was	be	VBD
cord-104162-fe51v2pt	53	14	duly	duly	RB
cord-104162-fe51v2pt	53	15	clarified	clarify	VBN
cord-104162-fe51v2pt	53	16	[	[	-LRB-
cord-104162-fe51v2pt	53	17	26	26	CD
cord-104162-fe51v2pt	53	18	]	]	-RRB-
cord-104162-fe51v2pt	53	19	,	,	,
cord-104162-fe51v2pt	53	20	the	the	DT
cord-104162-fe51v2pt	53	21	validity	validity	NN
cord-104162-fe51v2pt	53	22	of	of	IN
cord-104162-fe51v2pt	53	23	single	single	JJ
cord-104162-fe51v2pt	53	24	base	base	NN
cord-104162-fe51v2pt	53	25	level	level	NN
cord-104162-fe51v2pt	53	26	shuffling	shuffling	NN
cord-104162-fe51v2pt	53	27	is	be	VBZ
cord-104162-fe51v2pt	53	28	now	now	RB
cord-104162-fe51v2pt	53	29	generally	generally	RB
cord-104162-fe51v2pt	53	30	6	6	CD
cord-104162-fe51v2pt	53	31	accepted	accept	VBN
cord-104162-fe51v2pt	53	32	and	and	CC
cord-104162-fe51v2pt	53	33	is	be	VBZ
cord-104162-fe51v2pt	53	34	being	be	VBG
cord-104162-fe51v2pt	53	35	applied	apply	VBN
cord-104162-fe51v2pt	53	36	routinely	routinely	RB
cord-104162-fe51v2pt	53	37	to	to	IN
cord-104162-fe51v2pt	53	38	various	various	JJ
cord-104162-fe51v2pt	53	39	viral	viral	JJ
cord-104162-fe51v2pt	53	40	genomes	genome	NNS
cord-104162-fe51v2pt	53	41	[	[	-LRB-
cord-104162-fe51v2pt	53	42	15	15	CD
cord-104162-fe51v2pt	53	43	,	,	,
cord-104162-fe51v2pt	53	44	16	16	CD
cord-104162-fe51v2pt	53	45	,	,	,
cord-104162-fe51v2pt	53	46	27	27	CD
cord-104162-fe51v2pt	53	47	]	]	-RRB-
cord-104162-fe51v2pt	53	48	.	.	.
cord-104162-fe51v2pt	54	1	The	the	DT
cord-104162-fe51v2pt	54	2	Monte	Monte	NNP
cord-104162-fe51v2pt	54	3	Carlo	Carlo	NNP
cord-104162-fe51v2pt	54	4	procedure	procedure	NN
cord-104162-fe51v2pt	54	5	can	can	MD
cord-104162-fe51v2pt	54	6	also	also	RB
cord-104162-fe51v2pt	54	7	be	be	VB
cord-104162-fe51v2pt	54	8	simplified	simplify	VBN
cord-104162-fe51v2pt	54	9	to	to	TO
cord-104162-fe51v2pt	54	10	decrease	decrease	VB
cord-104162-fe51v2pt	54	11	FORS	FORS	NNP
cord-104162-fe51v2pt	54	12	-	-	HYPH
cord-104162-fe51v2pt	54	13	M	M	NNP
cord-104162-fe51v2pt	54	14	computational	computational	JJ
cord-104162-fe51v2pt	54	15	time	time	NN
cord-104162-fe51v2pt	54	16	[	[	-LRB-
cord-104162-fe51v2pt	54	17	28	28	CD
cord-104162-fe51v2pt	54	18	]	]	-RRB-
cord-104162-fe51v2pt	54	19	using	use	VBG
cord-104162-fe51v2pt	54	20	support	support	NN
cord-104162-fe51v2pt	54	21	vector	vector	NN
cord-104162-fe51v2pt	54	22	machine	machine	NN
cord-104162-fe51v2pt	54	23	-	-	HYPH
cord-104162-fe51v2pt	54	24	based	base	VBN
cord-104162-fe51v2pt	54	25	technology	technology	NN
cord-104162-fe51v2pt	54	26	[	[	-LRB-
cord-104162-fe51v2pt	54	27	29	29	CD
cord-104162-fe51v2pt	54	28	]	]	-RRB-
cord-104162-fe51v2pt	54	29	.	.	.
cord-104162-fe51v2pt	55	1	Our	-PRON-	PRP$
cord-104162-fe51v2pt	55	2	original	original	JJ
cord-104162-fe51v2pt	55	3	software	software	NN
cord-104162-fe51v2pt	55	4	(	(	-LRB-
cord-104162-fe51v2pt	55	5	"	"	``
cord-104162-fe51v2pt	55	6	Bodslp	Bodslp	NNP
cord-104162-fe51v2pt	55	7	"	"	''
cord-104162-fe51v2pt	55	8	)	)	-RRB-
cord-104162-fe51v2pt	55	9	,	,	,
cord-104162-fe51v2pt	55	10	written	write	VBN
cord-104162-fe51v2pt	55	11	by	by	IN
cord-104162-fe51v2pt	55	12	Professor	Professor	NNP
cord-104162-fe51v2pt	55	13	Jian	Jian	NNP
cord-104162-fe51v2pt	55	14	-	-	HYPH
cord-104162-fe51v2pt	55	15	sheng	sheng	NNP
cord-104162-fe51v2pt	55	16	Wu	Wu	NNP
cord-104162-fe51v2pt	56	1	[	[	-LRB-
cord-104162-fe51v2pt	56	2	30	30	CD
cord-104162-fe51v2pt	56	3	]	]	-RRB-
cord-104162-fe51v2pt	56	4	,	,	,
cord-104162-fe51v2pt	56	5	retains	retain	VBZ
cord-104162-fe51v2pt	56	6	the	the	DT
cord-104162-fe51v2pt	56	7	Monte	Monte	NNP
cord-104162-fe51v2pt	56	8	Carlo	Carlo	NNP
cord-104162-fe51v2pt	56	9	approach	approach	NN
cord-104162-fe51v2pt	56	10	and	and	CC
cord-104162-fe51v2pt	56	11	was	be	VBD
cord-104162-fe51v2pt	56	12	further	further	RB
cord-104162-fe51v2pt	56	13	developed	develop	VBN
cord-104162-fe51v2pt	56	14	by	by	IN
cord-104162-fe51v2pt	56	15	Professor	Professor	NNP
cord-104162-fe51v2pt	56	16	Shungao	Shungao	NNP
cord-104162-fe51v2pt	56	17	Xu	Xu	NNP
cord-104162-fe51v2pt	56	18	as	as	IN
cord-104162-fe51v2pt	56	19	"	"	``
cord-104162-fe51v2pt	56	20	Random	Random	NNP
cord-104162-fe51v2pt	56	21	Fold	Fold	NNP
cord-104162-fe51v2pt	56	22	-	-	HYPH
cord-104162-fe51v2pt	56	23	Scan	scan	NN
cord-104162-fe51v2pt	56	24	"	"	''
cord-104162-fe51v2pt	56	25	for	for	IN
cord-104162-fe51v2pt	56	26	Windows	Windows	NNP
cord-104162-fe51v2pt	56	27	-	-	HYPH
cord-104162-fe51v2pt	56	28	based	base	VBN
cord-104162-fe51v2pt	56	29	systems	system	NNS
cord-104162-fe51v2pt	56	30	[	[	-LRB-
cord-104162-fe51v2pt	56	31	31	31	CD
cord-104162-fe51v2pt	56	32	]	]	-RRB-
cord-104162-fe51v2pt	56	33	.	.	.
cord-104162-fe51v2pt	57	1	In	in	IN
cord-104162-fe51v2pt	57	2	addition	addition	NN
cord-104162-fe51v2pt	57	3	to	to	IN
cord-104162-fe51v2pt	57	4	assisting	assist	VBG
cord-104162-fe51v2pt	57	5	the	the	DT
cord-104162-fe51v2pt	57	6	study	study	NN
cord-104162-fe51v2pt	57	7	of	of	IN
cord-104162-fe51v2pt	57	8	infectious	infectious	JJ
cord-104162-fe51v2pt	57	9	viruses	virus	NNS
cord-104162-fe51v2pt	57	10	and	and	CC
cord-104162-fe51v2pt	57	11	protozoa	protozoan	NNS
cord-104162-fe51v2pt	57	12	[	[	-LRB-
cord-104162-fe51v2pt	57	13	32	32	CD
cord-104162-fe51v2pt	57	14	]	]	-RRB-
cord-104162-fe51v2pt	57	15	,	,	,
cord-104162-fe51v2pt	57	16	FORS	FORS	NNP
cord-104162-fe51v2pt	57	17	-	-	HYPH
cord-104162-fe51v2pt	57	18	D	D	NNP
cord-104162-fe51v2pt	57	19	analysis	analysis	NN
cord-104162-fe51v2pt	57	20	proved	prove	VBD
cord-104162-fe51v2pt	57	21	fruitful	fruitful	JJ
cord-104162-fe51v2pt	57	22	when	when	WRB
cord-104162-fe51v2pt	57	23	applied	apply	VBN
cord-104162-fe51v2pt	57	24	to	to	IN
cord-104162-fe51v2pt	57	25	topics	topic	NNS
cord-104162-fe51v2pt	57	26	such	such	JJ
cord-104162-fe51v2pt	57	27	as	as	IN
cord-104162-fe51v2pt	57	28	speciation	speciation	NN
cord-104162-fe51v2pt	57	29	[	[	-LRB-
cord-104162-fe51v2pt	57	30	3	3	CD
cord-104162-fe51v2pt	57	31	,	,	,
cord-104162-fe51v2pt	57	32	19	19	CD
cord-104162-fe51v2pt	57	33	,	,	,
cord-104162-fe51v2pt	57	34	33	33	CD
cord-104162-fe51v2pt	57	35	]	]	-RRB-
cord-104162-fe51v2pt	57	36	,	,	,
cord-104162-fe51v2pt	57	37	the	the	DT
cord-104162-fe51v2pt	57	38	origin	origin	NN
cord-104162-fe51v2pt	57	39	of	of	IN
cord-104162-fe51v2pt	57	40	introns	intron	NNS
cord-104162-fe51v2pt	57	41	[	[	-LRB-
cord-104162-fe51v2pt	57	42	23	23	CD
cord-104162-fe51v2pt	57	43	,	,	,
cord-104162-fe51v2pt	57	44	24	24	CD
cord-104162-fe51v2pt	57	45	,	,	,
cord-104162-fe51v2pt	57	46	34	34	CD
cord-104162-fe51v2pt	57	47	]	]	-RRB-
cord-104162-fe51v2pt	57	48	,	,	,
cord-104162-fe51v2pt	57	49	relating	relate	VBG
cord-104162-fe51v2pt	57	50	structure	structure	NN
cord-104162-fe51v2pt	57	51	to	to	IN
cord-104162-fe51v2pt	57	52	recombination	recombination	NN
cord-104162-fe51v2pt	57	53	breakpoints	breakpoint	NNS
cord-104162-fe51v2pt	57	54	and	and	CC
cord-104162-fe51v2pt	57	55	deletions	deletion	NNS
cord-104162-fe51v2pt	57	56	[	[	-LRB-
cord-104162-fe51v2pt	57	57	35	35	CD
cord-104162-fe51v2pt	57	58	,	,	,
cord-104162-fe51v2pt	57	59	36	36	CD
cord-104162-fe51v2pt	57	60	]	]	-RRB-
cord-104162-fe51v2pt	57	61	,	,	,
cord-104162-fe51v2pt	57	62	and	and	CC
cord-104162-fe51v2pt	57	63	relying	rely	VBG
cord-104162-fe51v2pt	57	64	on	on	IN
cord-104162-fe51v2pt	57	65	a	a	DT
cord-104162-fe51v2pt	57	66	single	single	JJ
cord-104162-fe51v2pt	57	67	sequence	sequence	NN
cord-104162-fe51v2pt	57	68	(	(	-LRB-
cord-104162-fe51v2pt	57	69	rather	rather	RB
cord-104162-fe51v2pt	57	70	than	than	IN
cord-104162-fe51v2pt	57	71	alignments	alignment	NNS
cord-104162-fe51v2pt	57	72	)	)	-RRB-
cord-104162-fe51v2pt	57	73	for	for	IN
cord-104162-fe51v2pt	57	74	the	the	DT
cord-104162-fe51v2pt	57	75	determination	determination	NN
cord-104162-fe51v2pt	57	76	of	of	IN
cord-104162-fe51v2pt	57	77	positive	positive	JJ
cord-104162-fe51v2pt	57	78	Darwinian	darwinian	JJ
cord-104162-fe51v2pt	57	79	selection	selection	NN
cord-104162-fe51v2pt	57	80	[	[	-LRB-
cord-104162-fe51v2pt	57	81	37	37	CD
cord-104162-fe51v2pt	57	82	]	]	-RRB-
cord-104162-fe51v2pt	57	83	.	.	.
cord-104162-fe51v2pt	58	1	However	however	RB
cord-104162-fe51v2pt	58	2	,	,	,
cord-104162-fe51v2pt	58	3	for	for	IN
cord-104162-fe51v2pt	58	4	a	a	DT
cord-104162-fe51v2pt	58	5	given	give	VBN
cord-104162-fe51v2pt	58	6	sequence	sequence	NN
cord-104162-fe51v2pt	58	7	window	window	NN
cord-104162-fe51v2pt	58	8	,	,	,
cord-104162-fe51v2pt	58	9	output	output	NN
cord-104162-fe51v2pt	58	10	can	can	MD
cord-104162-fe51v2pt	58	11	follow	follow	VB
cord-104162-fe51v2pt	58	12	only	only	RB
cord-104162-fe51v2pt	58	13	from	from	IN
cord-104162-fe51v2pt	58	14	the	the	DT
cord-104162-fe51v2pt	58	15	base	base	NN
cord-104162-fe51v2pt	58	16	order	order	NN
cord-104162-fe51v2pt	58	17	in	in	IN
cord-104162-fe51v2pt	58	18	that	that	DT
cord-104162-fe51v2pt	58	19	window	window	NN
cord-104162-fe51v2pt	58	20	.	.	.
cord-104162-fe51v2pt	59	1	Lost	lose	VBN
cord-104162-fe51v2pt	59	2	are	be	VBP
cord-104162-fe51v2pt	59	3	higher	high	JJR
cord-104162-fe51v2pt	59	4	order	order	NN
cord-104162-fe51v2pt	59	5	structures	structure	NNS
cord-104162-fe51v2pt	59	6	that	that	WDT
cord-104162-fe51v2pt	59	7	might	may	MD
cord-104162-fe51v2pt	59	8	occur	occur	VB
cord-104162-fe51v2pt	59	9	naturally	naturally	RB
cord-104162-fe51v2pt	59	10	through	through	IN
cord-104162-fe51v2pt	59	11	long	long	JJ
cord-104162-fe51v2pt	59	12	-	-	HYPH
cord-104162-fe51v2pt	59	13	range	range	NN
cord-104162-fe51v2pt	59	14	interactions	interaction	NNS
cord-104162-fe51v2pt	59	15	[	[	-LRB-
cord-104162-fe51v2pt	59	16	14	14	CD
cord-104162-fe51v2pt	59	17	]	]	-RRB-
cord-104162-fe51v2pt	59	18	.	.	.
cord-104162-fe51v2pt	60	1	Furthermore	furthermore	RB
cord-104162-fe51v2pt	60	2	,	,	,
cord-104162-fe51v2pt	60	3	if	if	IN
cord-104162-fe51v2pt	60	4	the	the	DT
cord-104162-fe51v2pt	60	5	artificial	artificial	JJ
cord-104162-fe51v2pt	60	6	demarcation	demarcation	NN
cord-104162-fe51v2pt	60	7	of	of	IN
cord-104162-fe51v2pt	60	8	a	a	DT
cord-104162-fe51v2pt	60	9	window	window	NN
cord-104162-fe51v2pt	60	10	happens	happen	VBZ
cord-104162-fe51v2pt	60	11	to	to	TO
cord-104162-fe51v2pt	60	12	cut	cut	VB
cord-104162-fe51v2pt	60	13	between	between	IN
cord-104162-fe51v2pt	60	14	the	the	DT
cord-104162-fe51v2pt	60	15	two	two	CD
cord-104162-fe51v2pt	60	16	limbs	limb	NNS
cord-104162-fe51v2pt	60	17	of	of	IN
cord-104162-fe51v2pt	60	18	a	a	DT
cord-104162-fe51v2pt	60	19	natural	natural	JJ
cord-104162-fe51v2pt	60	20	stem	stem	NN
cord-104162-fe51v2pt	60	21	-	-	HYPH
cord-104162-fe51v2pt	60	22	loop	loop	NN
cord-104162-fe51v2pt	60	23	structure	structure	NN
cord-104162-fe51v2pt	60	24	,	,	,
cord-104162-fe51v2pt	60	25	then	then	RB
cord-104162-fe51v2pt	60	26	lost	lose	VBN
cord-104162-fe51v2pt	60	27	are	be	VBP
cord-104162-fe51v2pt	60	28	what	what	WP
cord-104162-fe51v2pt	60	29	might	may	MD
cord-104162-fe51v2pt	60	30	have	have	VB
cord-104162-fe51v2pt	60	31	been	be	VBN
cord-104162-fe51v2pt	60	32	contributed	contribute	VBN
cord-104162-fe51v2pt	60	33	to	to	IN
cord-104162-fe51v2pt	60	34	the	the	DT
cord-104162-fe51v2pt	60	35	folding	fold	VBG
cord-104162-fe51v2pt	60	36	energetics	energetic	NNS
cord-104162-fe51v2pt	60	37	had	have	VBD
cord-104162-fe51v2pt	60	38	a	a	DT
cord-104162-fe51v2pt	60	39	larger	large	JJR
cord-104162-fe51v2pt	60	40	window	window	NN
cord-104162-fe51v2pt	60	41	,	,	,
cord-104162-fe51v2pt	60	42	or	or	CC
cord-104162-fe51v2pt	60	43	a	a	DT
cord-104162-fe51v2pt	60	44	different	different	JJ
cord-104162-fe51v2pt	60	45	section	section	NN
cord-104162-fe51v2pt	60	46	point	point	NN
cord-104162-fe51v2pt	60	47	,	,	,
cord-104162-fe51v2pt	60	48	been	be	VBN
cord-104162-fe51v2pt	60	49	chosen	choose	VBN
cord-104162-fe51v2pt	60	50	.	.	.
cord-104162-fe51v2pt	61	1	Variations	variation	NNS
cord-104162-fe51v2pt	61	2	in	in	IN
cord-104162-fe51v2pt	61	3	step	step	NN
cord-104162-fe51v2pt	61	4	size	size	NN
cord-104162-fe51v2pt	61	5	will	will	MD
cord-104162-fe51v2pt	61	6	generate	generate	VB
cord-104162-fe51v2pt	61	7	differences	difference	NNS
cord-104162-fe51v2pt	61	8	in	in	IN
cord-104162-fe51v2pt	61	9	windows	window	NNS
cord-104162-fe51v2pt	61	10	and	and	CC
cord-104162-fe51v2pt	61	11	hence	hence	RB
cord-104162-fe51v2pt	61	12	variations	variation	NNS
cord-104162-fe51v2pt	61	13	in	in	IN
cord-104162-fe51v2pt	61	14	results	result	NNS
cord-104162-fe51v2pt	61	15	.	.	.
cord-104162-fe51v2pt	62	1	Such	such	JJ
cord-104162-fe51v2pt	62	2	variations	variation	NNS
cord-104162-fe51v2pt	62	3	might	may	MD
cord-104162-fe51v2pt	62	4	be	be	VB
cord-104162-fe51v2pt	62	5	less	less	JJR
cord-104162-fe51v2pt	62	6	when	when	WRB
cord-104162-fe51v2pt	62	7	window	window	NN
cord-104162-fe51v2pt	62	8	margins	margin	NNS
cord-104162-fe51v2pt	62	9	correspond	correspond	VBP
cord-104162-fe51v2pt	62	10	to	to	IN
cord-104162-fe51v2pt	62	11	natural	natural	JJ
cord-104162-fe51v2pt	62	12	section	section	NN
cord-104162-fe51v2pt	62	13	points	point	NNS
cord-104162-fe51v2pt	62	14	,	,	,
cord-104162-fe51v2pt	62	15	such	such	JJ
cord-104162-fe51v2pt	62	16	as	as	IN
cord-104162-fe51v2pt	62	17	those	those	DT
cord-104162-fe51v2pt	62	18	demarcating	demarcate	VBG
cord-104162-fe51v2pt	62	19	an	an	DT
cord-104162-fe51v2pt	62	20	RNA	RNA	NNP
cord-104162-fe51v2pt	62	21	transcript	transcript	NN
cord-104162-fe51v2pt	62	22	.	.	.
cord-104162-fe51v2pt	63	1	There	there	EX
cord-104162-fe51v2pt	63	2	is	be	VBZ
cord-104162-fe51v2pt	63	3	also	also	RB
cord-104162-fe51v2pt	63	4	a	a	DT
cord-104162-fe51v2pt	63	5	kinetic	kinetic	JJ
cord-104162-fe51v2pt	63	6	aspect	aspect	NN
cord-104162-fe51v2pt	63	7	,	,	,
cord-104162-fe51v2pt	63	8	particularly	particularly	RB
cord-104162-fe51v2pt	63	9	apparent	apparent	JJ
cord-104162-fe51v2pt	63	10	with	with	IN
cord-104162-fe51v2pt	63	11	transcripts	transcript	NNS
cord-104162-fe51v2pt	63	12	,	,	,
cord-104162-fe51v2pt	63	13	due	due	IN
cord-104162-fe51v2pt	63	14	to	to	IN
cord-104162-fe51v2pt	63	15	the	the	DT
cord-104162-fe51v2pt	63	16	probability	probability	NN
cord-104162-fe51v2pt	63	17	that	that	IN
cord-104162-fe51v2pt	63	18	the	the	DT
cord-104162-fe51v2pt	63	19	pattern	pattern	NN
cord-104162-fe51v2pt	63	20	of	of	IN
cord-104162-fe51v2pt	63	21	early	early	JJ
cord-104162-fe51v2pt	63	22	5	5	CD
cord-104162-fe51v2pt	63	23	'	'	''
cord-104162-fe51v2pt	63	24	folding	folding	NN
cord-104162-fe51v2pt	63	25	will	will	MD
cord-104162-fe51v2pt	63	26	influence	influence	VB
cord-104162-fe51v2pt	63	27	later	later	RB
cord-104162-fe51v2pt	63	28	folding	fold	VBG
cord-104162-fe51v2pt	63	29	.	.	.
cord-104162-fe51v2pt	64	1	High	high	JJ
cord-104162-fe51v2pt	64	2	negative	negative	JJ
cord-104162-fe51v2pt	64	3	SI	si	NN
cord-104162-fe51v2pt	64	4	values	value	NNS
cord-104162-fe51v2pt	64	5	indicate	indicate	VBP
cord-104162-fe51v2pt	64	6	structural	structural	JJ
cord-104162-fe51v2pt	64	7	conservation	conservation	NN
cord-104162-fe51v2pt	64	8	among	among	IN
cord-104162-fe51v2pt	64	9	a	a	DT
cord-104162-fe51v2pt	64	10	set	set	NN
cord-104162-fe51v2pt	64	11	of	of	IN
cord-104162-fe51v2pt	64	12	genomes	genome	NNS
cord-104162-fe51v2pt	64	13	.	.	.
cord-104162-fe51v2pt	65	1	The	the	DT
cord-104162-fe51v2pt	65	2	validity	validity	NN
cord-104162-fe51v2pt	65	3	of	of	IN
cord-104162-fe51v2pt	65	4	this	this	DT
cord-104162-fe51v2pt	65	5	approach	approach	NN
cord-104162-fe51v2pt	65	6	is	be	VBZ
cord-104162-fe51v2pt	65	7	supported	support	VBN
cord-104162-fe51v2pt	65	8	by	by	IN
cord-104162-fe51v2pt	65	9	prior	prior	JJ
cord-104162-fe51v2pt	65	10	work	work	NN
cord-104162-fe51v2pt	65	11	with	with	IN
cord-104162-fe51v2pt	65	12	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	65	13	.	.	.
cord-104162-fe51v2pt	66	1	Fig	Fig	NNP
cord-104162-fe51v2pt	66	2	.	.	NNP
cord-104162-fe51v2pt	66	3	1	1	CD
cord-104162-fe51v2pt	66	4	shows	show	VBZ
cord-104162-fe51v2pt	66	5	application	application	NN
cord-104162-fe51v2pt	66	6	of	of	IN
cord-104162-fe51v2pt	66	7	the	the	DT
cord-104162-fe51v2pt	66	8	index	index	NN
cord-104162-fe51v2pt	66	9	to	to	TO
cord-104162-fe51v2pt	66	10	previously	previously	RB
cord-104162-fe51v2pt	66	11	reported	report	VBN
cord-104162-fe51v2pt	66	12	data	datum	NNS
cord-104162-fe51v2pt	66	13	on	on	IN
cord-104162-fe51v2pt	66	14	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	66	15	[	[	-LRB-
cord-104162-fe51v2pt	66	16	2	2	CD
cord-104162-fe51v2pt	66	17	]	]	-RRB-
cord-104162-fe51v2pt	66	18	.	.	.
cord-104162-fe51v2pt	67	1	Here	here	RB
cord-104162-fe51v2pt	67	2	a	a	DT
cord-104162-fe51v2pt	67	3	high	high	JJ
cord-104162-fe51v2pt	67	4	negative	negative	JJ
cord-104162-fe51v2pt	67	5	SI	SI	NNP
cord-104162-fe51v2pt	67	6	index	index	NN
cord-104162-fe51v2pt	67	7	value	value	NN
cord-104162-fe51v2pt	67	8	corresponds	correspond	VBZ
cord-104162-fe51v2pt	67	9	7	7	CD
cord-104162-fe51v2pt	67	10	to	to	IN
cord-104162-fe51v2pt	67	11	regions	region	NNS
cord-104162-fe51v2pt	67	12	recognized	recognize	VBN
cord-104162-fe51v2pt	67	13	as	as	RB
cord-104162-fe51v2pt	67	14	likely	likely	JJ
cord-104162-fe51v2pt	67	15	to	to	TO
cord-104162-fe51v2pt	67	16	offer	offer	VB
cord-104162-fe51v2pt	67	17	Achilles	Achilles	NNP
cord-104162-fe51v2pt	67	18	heel	heel	NN
cord-104162-fe51v2pt	67	19	-	-	HYPH
cord-104162-fe51v2pt	67	20	like	like	JJ
cord-104162-fe51v2pt	67	21	vulnerability	vulnerability	NN
cord-104162-fe51v2pt	67	22	[	[	-LRB-
cord-104162-fe51v2pt	67	23	7	7	CD
cord-104162-fe51v2pt	67	24	]	]	-RRB-
cord-104162-fe51v2pt	67	25	.	.	.
cord-104162-fe51v2pt	68	1	The	the	DT
cord-104162-fe51v2pt	68	2	region	region	NN
cord-104162-fe51v2pt	68	3	around	around	IN
cord-104162-fe51v2pt	68	4	the	the	DT
cord-104162-fe51v2pt	68	5	window	window	NN
cord-104162-fe51v2pt	68	6	centered	center	VBN
cord-104162-fe51v2pt	68	7	on	on	IN
cord-104162-fe51v2pt	68	8	500	500	CD
cord-104162-fe51v2pt	68	9	nucleotide	nucleotide	JJ
cord-104162-fe51v2pt	68	10	bases	basis	NNS
cord-104162-fe51v2pt	68	11	is	be	VBZ
cord-104162-fe51v2pt	68	12	the	the	DT
cord-104162-fe51v2pt	68	13	focus	focus	NN
cord-104162-fe51v2pt	68	14	of	of	IN
cord-104162-fe51v2pt	68	15	recent	recent	JJ
cord-104162-fe51v2pt	68	16	work	work	NN
cord-104162-fe51v2pt	68	17	[	[	-LRB-
cord-104162-fe51v2pt	68	18	4	4	CD
cord-104162-fe51v2pt	68	19	]	]	-RRB-
cord-104162-fe51v2pt	68	20	[	[	-LRB-
cord-104162-fe51v2pt	68	21	5	5	CD
cord-104162-fe51v2pt	68	22	]	]	-RRB-
cord-104162-fe51v2pt	68	23	[	[	-LRB-
cord-104162-fe51v2pt	68	24	6	6	CD
cord-104162-fe51v2pt	68	25	]	]	-RRB-
cord-104162-fe51v2pt	68	26	.	.	.
cord-104162-fe51v2pt	69	1	subtype	subtype	NN
cord-104162-fe51v2pt	69	2	(	(	-LRB-
cord-104162-fe51v2pt	69	3	HXB2	HXB2	NNP
cord-104162-fe51v2pt	69	4	)	)	-RRB-
cord-104162-fe51v2pt	70	1	[	[	-LRB-
cord-104162-fe51v2pt	70	2	2	2	CD
cord-104162-fe51v2pt	70	3	,	,	,
cord-104162-fe51v2pt	70	4	3	3	CD
cord-104162-fe51v2pt	70	5	]	]	-RRB-
cord-104162-fe51v2pt	70	6	.	.	.
cord-104162-fe51v2pt	71	1	The	the	DT
cord-104162-fe51v2pt	71	2	region	region	NN
cord-104162-fe51v2pt	71	3	recently	recently	RB
cord-104162-fe51v2pt	71	4	recognized	recognize	VBD
cord-104162-fe51v2pt	71	5	as	as	IN
cord-104162-fe51v2pt	71	6	a	a	DT
cord-104162-fe51v2pt	71	7	potential	potential	JJ
cord-104162-fe51v2pt	71	8	Achilles	Achilles	NNP
cord-104162-fe51v2pt	71	9	heel	heel	NN
cord-104162-fe51v2pt	71	10	(	(	-LRB-
cord-104162-fe51v2pt	71	11	bases	basis	NNS
cord-104162-fe51v2pt	71	12	380	380	CD
cord-104162-fe51v2pt	71	13	-	-	HYPH
cord-104162-fe51v2pt	71	14	640	640	CD
cord-104162-fe51v2pt	71	15	)	)	-RRB-
cord-104162-fe51v2pt	71	16	[	[	-LRB-
cord-104162-fe51v2pt	71	17	4	4	LS
cord-104162-fe51v2pt	71	18	]	]	-RRB-
cord-104162-fe51v2pt	71	19	[	[	-LRB-
cord-104162-fe51v2pt	71	20	5	5	CD
cord-104162-fe51v2pt	71	21	]	]	-RRB-
cord-104162-fe51v2pt	71	22	[	[	-LRB-
cord-104162-fe51v2pt	71	23	6	6	CD
cord-104162-fe51v2pt	71	24	]	]	-RRB-
cord-104162-fe51v2pt	71	25	,	,	,
cord-104162-fe51v2pt	71	26	has	have	VBZ
cord-104162-fe51v2pt	71	27	a	a	DT
cord-104162-fe51v2pt	71	28	high	high	JJ
cord-104162-fe51v2pt	71	29	negative	negative	JJ
cord-104162-fe51v2pt	71	30	FORS	fors	NN
cord-104162-fe51v2pt	71	31	-	-	HYPH
cord-104162-fe51v2pt	71	32	D	d	NN
cord-104162-fe51v2pt	71	33	value	value	NN
cord-104162-fe51v2pt	71	34	(	(	-LRB-
cord-104162-fe51v2pt	71	35	black	black	JJ
cord-104162-fe51v2pt	71	36	triangles	triangle	NNS
cord-104162-fe51v2pt	71	37	)	)	-RRB-
cord-104162-fe51v2pt	71	38	similar	similar	JJ
cord-104162-fe51v2pt	71	39	to	to	IN
cord-104162-fe51v2pt	71	40	those	those	DT
cord-104162-fe51v2pt	71	41	of	of	IN
cord-104162-fe51v2pt	71	42	the	the	DT
cord-104162-fe51v2pt	71	43	RRE	RRE	NNP
cord-104162-fe51v2pt	71	44	(	(	-LRB-
cord-104162-fe51v2pt	71	45	Rev	Rev	NNP
cord-104162-fe51v2pt	71	46	response	response	NN
cord-104162-fe51v2pt	71	47	element	element	NN
cord-104162-fe51v2pt	71	48	)	)	-RRB-
cord-104162-fe51v2pt	71	49	and	and	CC
cord-104162-fe51v2pt	71	50	the	the	DT
cord-104162-fe51v2pt	71	51	3	3	CD
cord-104162-fe51v2pt	71	52	'	'	POS
cord-104162-fe51v2pt	71	53	untranslated	untranslated	JJ
cord-104162-fe51v2pt	71	54	region	region	NN
cord-104162-fe51v2pt	71	55	(	(	-LRB-
cord-104162-fe51v2pt	71	56	UTR	UTR	NNP
cord-104162-fe51v2pt	71	57	)	)	-RRB-
cord-104162-fe51v2pt	71	58	.	.	.
cord-104162-fe51v2pt	72	1	The	the	DT
cord-104162-fe51v2pt	72	2	SI	SI	NNP
cord-104162-fe51v2pt	72	3	index	index	NN
cord-104162-fe51v2pt	72	4	(	(	-LRB-
cord-104162-fe51v2pt	72	5	continuous	continuous	JJ
cord-104162-fe51v2pt	72	6	red	red	JJ
cord-104162-fe51v2pt	72	7	line	line	NN
cord-104162-fe51v2pt	72	8	)	)	-RRB-
cord-104162-fe51v2pt	72	9	indicates	indicate	VBZ
cord-104162-fe51v2pt	72	10	highest	high	JJS
cord-104162-fe51v2pt	72	11	sequence	sequence	NN
cord-104162-fe51v2pt	72	12	conservation	conservation	NN
cord-104162-fe51v2pt	72	13	in	in	IN
cord-104162-fe51v2pt	72	14	the	the	DT
cord-104162-fe51v2pt	72	15	regions	region	NNS
cord-104162-fe51v2pt	72	16	of	of	IN
cord-104162-fe51v2pt	72	17	the	the	DT
cord-104162-fe51v2pt	72	18	RNA	RNA	NNP
cord-104162-fe51v2pt	72	19	packaging	packaging	NN
cord-104162-fe51v2pt	72	20	signal	signal	NN
cord-104162-fe51v2pt	72	21	and	and	CC
cord-104162-fe51v2pt	72	22	the	the	DT
cord-104162-fe51v2pt	72	23	3'UTR	3'utr	CD
cord-104162-fe51v2pt	72	24	.	.	.
cord-104162-fe51v2pt	72	25	 	 	_SP
cord-104162-fe51v2pt	73	1	2	2	LS
cord-104162-fe51v2pt	73	2	.	.	.
cord-104162-fe51v2pt	73	3	1	1	CD
cord-104162-fe51v2pt	73	4	.	.	.
cord-104162-fe51v2pt	74	1	V	v	LS
cord-104162-fe51v2pt	74	2	a	a	DT
cord-104162-fe51v2pt	74	3	r	r	NN
cord-104162-fe51v2pt	74	4	i	i	NN
cord-104162-fe51v2pt	74	5	ation	ation	NN
cord-104162-fe51v2pt	74	6	d	d	NNP
cord-104162-fe51v2pt	75	1	u	u	NNP
cord-104162-fe51v2pt	75	2	e	e	NN
cord-104162-fe51v2pt	75	3	t	t	NN
cord-104162-fe51v2pt	76	1	o	o	UH
cord-104162-fe51v2pt	77	1	b	b	LS
cord-104162-fe51v2pt	78	1	The	the	DT
cord-104162-fe51v2pt	78	2	degree	degree	NN
cord-104162-fe51v2pt	78	3	of	of	IN
cord-104162-fe51v2pt	78	4	conservation	conservation	NN
cord-104162-fe51v2pt	78	5	in	in	IN
cord-104162-fe51v2pt	78	6	sequential	sequential	JJ
cord-104162-fe51v2pt	78	7	windows	window	NNS
cord-104162-fe51v2pt	78	8	of	of	IN
cord-104162-fe51v2pt	78	9	members	member	NNS
cord-104162-fe51v2pt	78	10	of	of	IN
cord-104162-fe51v2pt	78	11	a	a	DT
cord-104162-fe51v2pt	78	12	set	set	NN
cord-104162-fe51v2pt	78	13	of	of	IN
cord-104162-fe51v2pt	78	14	sequences	sequence	NNS
cord-104162-fe51v2pt	78	15	from	from	IN
cord-104162-fe51v2pt	78	16	China	China	NNP
cord-104162-fe51v2pt	78	17	was	be	VBD
cord-104162-fe51v2pt	78	18	evaluated	evaluate	VBN
cord-104162-fe51v2pt	78	19	as	as	IN
cord-104162-fe51v2pt	78	20	the	the	DT
cord-104162-fe51v2pt	78	21	number	number	NN
cord-104162-fe51v2pt	78	22	of	of	IN
cord-104162-fe51v2pt	78	23	substitutable	substitutable	JJ
cord-104162-fe51v2pt	78	24	base	base	NN
cord-104162-fe51v2pt	78	25	positions	position	NNS
cord-104162-fe51v2pt	78	26	(	(	-LRB-
cord-104162-fe51v2pt	78	27	polymorphism	polymorphism	NN
cord-104162-fe51v2pt	78	28	)	)	-RRB-
cord-104162-fe51v2pt	78	29	,	,	,
cord-104162-fe51v2pt	78	30	relative	relative	JJ
cord-104162-fe51v2pt	78	31	to	to	IN
cord-104162-fe51v2pt	78	32	the	the	DT
cord-104162-fe51v2pt	78	33	prototype	prototype	NN
cord-104162-fe51v2pt	78	34	sequence	sequence	NN
cord-104162-fe51v2pt	78	35	(	(	-LRB-
cord-104162-fe51v2pt	78	36	Fig	Fig	NNP
cord-104162-fe51v2pt	78	37	.	.	.
cord-104162-fe51v2pt	78	38	3	3	CD
cord-104162-fe51v2pt	78	39	)	)	-RRB-
cord-104162-fe51v2pt	78	40	.	.	.
cord-104162-fe51v2pt	79	1	This	this	DT
cord-104162-fe51v2pt	79	2	was	be	VBD
cord-104162-fe51v2pt	79	3	compared	compare	VBN
cord-104162-fe51v2pt	79	4	with	with	IN
cord-104162-fe51v2pt	79	5	corresponding	correspond	VBG
cord-104162-fe51v2pt	79	6	FORS	FORS	NNP
cord-104162-fe51v2pt	79	7	-	-	HYPH
cord-104162-fe51v2pt	79	8	D	d	JJ
cord-104162-fe51v2pt	79	9	values	value	NNS
cord-104162-fe51v2pt	79	10	,	,	,
cord-104162-fe51v2pt	79	11	the	the	DT
cord-104162-fe51v2pt	79	12	profile	profile	NN
cord-104162-fe51v2pt	79	13	of	of	IN
cord-104162-fe51v2pt	79	14	which	which	WDT
cord-104162-fe51v2pt	79	15	differed	differ	VBD
cord-104162-fe51v2pt	79	16	a	a	DT
cord-104162-fe51v2pt	79	17	little	little	JJ
cord-104162-fe51v2pt	79	18	from	from	IN
cord-104162-fe51v2pt	79	19	that	that	DT
cord-104162-fe51v2pt	79	20	of	of	IN
cord-104162-fe51v2pt	79	21	Fig	Fig	NNP
cord-104162-fe51v2pt	79	22	.	.	.
cord-104162-fe51v2pt	80	1	2	2	LS
cord-104162-fe51v2pt	80	2	due	due	IN
cord-104162-fe51v2pt	80	3	to	to	IN
cord-104162-fe51v2pt	80	4	different	different	JJ
cord-104162-fe51v2pt	80	5	step	step	NN
cord-104162-fe51v2pt	80	6	values	value	NNS
cord-104162-fe51v2pt	80	7	(	(	-LRB-
cord-104162-fe51v2pt	80	8	see	see	VB
cord-104162-fe51v2pt	80	9	Materials	material	NNS
cord-104162-fe51v2pt	80	10	and	and	CC
cord-104162-fe51v2pt	80	11	Methods	Methods	NNPS
cord-104162-fe51v2pt	80	12	)	)	-RRB-
cord-104162-fe51v2pt	80	13	.	.	.
cord-104162-fe51v2pt	81	1	As	as	IN
cord-104162-fe51v2pt	81	2	with	with	IN
cord-104162-fe51v2pt	81	3	some	some	DT
cord-104162-fe51v2pt	81	4	previous	previous	JJ
cord-104162-fe51v2pt	81	5	studies	study	NNS
cord-104162-fe51v2pt	81	6	[	[	-LRB-
cord-104162-fe51v2pt	81	7	23	23	CD
cord-104162-fe51v2pt	81	8	]	]	-RRB-
cord-104162-fe51v2pt	81	9	,	,	,
cord-104162-fe51v2pt	81	10	there	there	EX
cord-104162-fe51v2pt	81	11	tended	tend	VBD
cord-104162-fe51v2pt	81	12	to	to	TO
cord-104162-fe51v2pt	81	13	be	be	VB
cord-104162-fe51v2pt	81	14	a	a	DT
cord-104162-fe51v2pt	81	15	reciprocal	reciprocal	JJ
cord-104162-fe51v2pt	81	16	relationship	relationship	NN
cord-104162-fe51v2pt	81	17	between	between	IN
cord-104162-fe51v2pt	81	18	the	the	DT
cord-104162-fe51v2pt	81	19	 	 	_SP
cord-104162-fe51v2pt	81	20	For	for	IN
cord-104162-fe51v2pt	81	21	a	a	DT
cord-104162-fe51v2pt	81	22	more	more	RBR
cord-104162-fe51v2pt	81	23	focused	focused	JJ
cord-104162-fe51v2pt	81	24	view	view	NN
cord-104162-fe51v2pt	81	25	of	of	IN
cord-104162-fe51v2pt	81	26	the	the	DT
cord-104162-fe51v2pt	81	27	reciprocal	reciprocal	JJ
cord-104162-fe51v2pt	81	28	separation	separation	NN
cord-104162-fe51v2pt	81	29	of	of	IN
cord-104162-fe51v2pt	81	30	high	high	JJ
cord-104162-fe51v2pt	81	31	negative	negative	JJ
cord-104162-fe51v2pt	81	32	folding	fold	VBG
cord-104162-fe51v2pt	81	33	values	value	NNS
cord-104162-fe51v2pt	81	34	and	and	CC
cord-104162-fe51v2pt	81	35	corresponding	correspond	VBG
cord-104162-fe51v2pt	81	36	numbers	number	NNS
cord-104162-fe51v2pt	81	37	of	of	IN
cord-104162-fe51v2pt	81	38	substitutions	substitution	NNS
cord-104162-fe51v2pt	81	39	(	(	-LRB-
cord-104162-fe51v2pt	81	40	ranging	range	VBG
cord-104162-fe51v2pt	81	41	from	from	IN
cord-104162-fe51v2pt	81	42	zero	zero	CD
cord-104162-fe51v2pt	81	43	to	to	IN
cord-104162-fe51v2pt	81	44	high	high	JJ
cord-104162-fe51v2pt	81	45	positive	positive	JJ
cord-104162-fe51v2pt	81	46	values	value	NNS
cord-104162-fe51v2pt	81	47	)	)	-RRB-
cord-104162-fe51v2pt	81	48	the	the	DT
cord-104162-fe51v2pt	81	49	two	two	CD
cord-104162-fe51v2pt	81	50	were	be	VBD
cord-104162-fe51v2pt	81	51	added	add	VBN
cord-104162-fe51v2pt	81	52	to	to	TO
cord-104162-fe51v2pt	81	53	provide	provide	VB
cord-104162-fe51v2pt	81	54	the	the	DT
cord-104162-fe51v2pt	81	55	"	"	``
cord-104162-fe51v2pt	81	56	structural	structural	JJ
cord-104162-fe51v2pt	81	57	invariance	invariance	NN
cord-104162-fe51v2pt	81	58	"	"	''
cord-104162-fe51v2pt	81	59	(	(	-LRB-
cord-104162-fe51v2pt	81	60	SI	SI	NNP
cord-104162-fe51v2pt	81	61	)	)	-RRB-
cord-104162-fe51v2pt	81	62	index	index	NN
cord-104162-fe51v2pt	81	63	(	(	-LRB-
cord-104162-fe51v2pt	81	64	Fig	Fig	NNP
cord-104162-fe51v2pt	81	65	.	.	NNP
cord-104162-fe51v2pt	81	66	4	4	CD
cord-104162-fe51v2pt	81	67	)	)	-RRB-
cord-104162-fe51v2pt	81	68	.	.	.
cord-104162-fe51v2pt	82	1	Here	here	RB
cord-104162-fe51v2pt	82	2	,	,	,
cord-104162-fe51v2pt	82	3	despite	despite	IN
cord-104162-fe51v2pt	82	4	having	have	VBG
cord-104162-fe51v2pt	82	5	some	some	DT
cord-104162-fe51v2pt	82	6	substitutions	substitution	NNS
cord-104162-fe51v2pt	82	7	,	,	,
cord-104162-fe51v2pt	82	8	ORFs	ORFs	NNP
cord-104162-fe51v2pt	82	9	NSP13	NSP13	NNP
cord-104162-fe51v2pt	82	10	and	and	CC
cord-104162-fe51v2pt	82	11	NSP3	NSP3	NNP
cord-104162-fe51v2pt	82	12	were	be	VBD
cord-104162-fe51v2pt	82	13	preeminent	preeminent	JJ
cord-104162-fe51v2pt	82	14	(	(	-LRB-
cord-104162-fe51v2pt	82	15	scoring	score	VBG
cord-104162-fe51v2pt	82	16	-	-	HYPH
cord-104162-fe51v2pt	82	17	a	a	DT
cord-104162-fe51v2pt	82	18	region	region	NN
cord-104162-fe51v2pt	82	19	with	with	IN
cord-104162-fe51v2pt	82	20	the	the	DT
cord-104162-fe51v2pt	82	21	highest	high	JJS
cord-104162-fe51v2pt	82	22	number	number	NN
cord-104162-fe51v2pt	82	23	of	of	IN
cord-104162-fe51v2pt	82	24	substitutions	substitution	NNS
cord-104162-fe51v2pt	82	25	(	(	-LRB-
cord-104162-fe51v2pt	82	26	see	see	VB
cord-104162-fe51v2pt	82	27	Fig	Fig	NNP
cord-104162-fe51v2pt	82	28	.	.	.
cord-104162-fe51v2pt	82	29	3	3	LS
cord-104162-fe51v2pt	82	30	)	)	-RRB-
cord-104162-fe51v2pt	82	31	centered	center	VBN
cord-104162-fe51v2pt	82	32	on	on	IN
cord-104162-fe51v2pt	82	33	base	base	NN
cord-104162-fe51v2pt	82	34	28900	28900	CD
cord-104162-fe51v2pt	83	1	(	(	-LRB-
cord-104162-fe51v2pt	83	2	scoring	score	VBG
cord-104162-fe51v2pt	83	3	+7.6	+7.6	NNP
cord-104162-fe51v2pt	83	4	SI	SI	NNP
cord-104162-fe51v2pt	83	5	units	unit	NNS
cord-104162-fe51v2pt	83	6	)	)	-RRB-
cord-104162-fe51v2pt	83	7	.	.	.
cord-104162-fe51v2pt	84	1	(	(	-LRB-
cord-104162-fe51v2pt	84	2	For	for	IN
cord-104162-fe51v2pt	84	3	plots	plot	NNS
cord-104162-fe51v2pt	84	4	of	of	IN
cord-104162-fe51v2pt	84	5	analogous	analogous	JJ
cord-104162-fe51v2pt	84	6	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	84	7	data	datum	NNS
cord-104162-fe51v2pt	84	8	see	see	VBP
cord-104162-fe51v2pt	84	9	Fig	Fig	NNP
cord-104162-fe51v2pt	84	10	.	.	NNP
cord-104162-fe51v2pt	84	11	1	1	CD
cord-104162-fe51v2pt	84	12	)	)	-RRB-
cord-104162-fe51v2pt	84	13	.	.	.
cord-104162-fe51v2pt	85	1	Windows	Windows	NNP
cord-104162-fe51v2pt	85	2	13400	13400	CD
cord-104162-fe51v2pt	85	3	and	and	CC
cord-104162-fe51v2pt	85	4	13450	13450	CD
cord-104162-fe51v2pt	85	5	in	in	IN
cord-104162-fe51v2pt	85	6	the	the	DT
cord-104162-fe51v2pt	85	7	FSE	FSE	NNP
cord-104162-fe51v2pt	85	8	region	region	NN
cord-104162-fe51v2pt	85	9	scored	score	VBD
cord-104162-fe51v2pt	85	10	-12.5	-12.5	NNP
cord-104162-fe51v2pt	85	11	and	and	CC
cord-104162-fe51v2pt	85	12	-13.7	-13.7	CD
cord-104162-fe51v2pt	85	13	units	unit	NNS
cord-104162-fe51v2pt	85	14	,	,	,
cord-104162-fe51v2pt	85	15	respectively	respectively	RB
cord-104162-fe51v2pt	85	16	.	.	.
cord-104162-fe51v2pt	86	1	However	however	RB
cord-104162-fe51v2pt	86	2	,	,	,
cord-104162-fe51v2pt	86	3	there	there	EX
cord-104162-fe51v2pt	86	4	were	be	VBD
cord-104162-fe51v2pt	86	5	many	many	JJ
cord-104162-fe51v2pt	86	6	more	more	JJR
cord-104162-fe51v2pt	86	7	windows	window	NNS
cord-104162-fe51v2pt	86	8	with	with	IN
cord-104162-fe51v2pt	86	9	higher	high	JJR
cord-104162-fe51v2pt	86	10	negative	negative	JJ
cord-104162-fe51v2pt	86	11	scores	score	NNS
cord-104162-fe51v2pt	86	12	.	.	.
cord-104162-fe51v2pt	86	13	 	 	_SP
cord-104162-fe51v2pt	87	1	The	the	DT
cord-104162-fe51v2pt	87	2	SI	SI	NNP
cord-104162-fe51v2pt	87	3	profile	profile	NN
cord-104162-fe51v2pt	87	4	for	for	IN
cord-104162-fe51v2pt	87	5	China	China	NNP
cord-104162-fe51v2pt	88	1	(	(	-LRB-
cord-104162-fe51v2pt	88	2	Fig	Fig	NNP
cord-104162-fe51v2pt	88	3	.	.	NNP
cord-104162-fe51v2pt	88	4	4	4	LS
cord-104162-fe51v2pt	88	5	)	)	-RRB-
cord-104162-fe51v2pt	88	6	was	be	VBD
cord-104162-fe51v2pt	88	7	,	,	,
cord-104162-fe51v2pt	88	8	in	in	IN
cord-104162-fe51v2pt	88	9	broad	broad	JJ
cord-104162-fe51v2pt	88	10	outline	outline	NN
cord-104162-fe51v2pt	88	11	,	,	,
cord-104162-fe51v2pt	88	12	confirmed	confirm	VBN
cord-104162-fe51v2pt	88	13	with	with	IN
cord-104162-fe51v2pt	88	14	corresponding	correspond	VBG
cord-104162-fe51v2pt	88	15	data	datum	NNS
cord-104162-fe51v2pt	88	16	later	later	RB
cord-104162-fe51v2pt	88	17	downloaded	download	VBN
cord-104162-fe51v2pt	88	18	from	from	IN
cord-104162-fe51v2pt	88	19	Italy	Italy	NNP
cord-104162-fe51v2pt	88	20	and	and	CC
cord-104162-fe51v2pt	88	21	New	New	NNP
cord-104162-fe51v2pt	88	22	York	York	NNP
cord-104162-fe51v2pt	88	23	,	,	,
cord-104162-fe51v2pt	88	24	USA	USA	NNP
cord-104162-fe51v2pt	89	1	(	(	-LRB-
cord-104162-fe51v2pt	89	2	Fig	Fig	NNP
cord-104162-fe51v2pt	89	3	.	.	NNP
cord-104162-fe51v2pt	89	4	5	5	CD
cord-104162-fe51v2pt	89	5	)	)	-RRB-
cord-104162-fe51v2pt	89	6	.	.	.
cord-104162-fe51v2pt	90	1	The	the	DT
cord-104162-fe51v2pt	90	2	high	high	JJ
cord-104162-fe51v2pt	90	3	negative	negative	JJ
cord-104162-fe51v2pt	90	4	SI	SI	NNP
cord-104162-fe51v2pt	90	5	indices	index	NNS
cord-104162-fe51v2pt	90	6	found	find	VBN
cord-104162-fe51v2pt	90	7	in	in	IN
cord-104162-fe51v2pt	90	8	the	the	DT
cord-104162-fe51v2pt	90	9	NSP3	NSP3	NNP
cord-104162-fe51v2pt	90	10	,	,	,
cord-104162-fe51v2pt	90	11	NSP13	NSP13	NNP
cord-104162-fe51v2pt	90	12	,	,	,
cord-104162-fe51v2pt	90	13	ORF3a	ORF3a	NNP
cord-104162-fe51v2pt	90	14	and	and	CC
cord-104162-fe51v2pt	90	15	N	n	CD
cord-104162-fe51v2pt	90	16	regions	region	NNS
cord-104162-fe51v2pt	90	17	,	,	,
cord-104162-fe51v2pt	90	18	were	be	VBD
cord-104162-fe51v2pt	90	19	evident	evident	JJ
cord-104162-fe51v2pt	90	20	with	with	IN
cord-104162-fe51v2pt	90	21	sequences	sequence	NNS
cord-104162-fe51v2pt	90	22	for	for	IN
cord-104162-fe51v2pt	90	23	all	all	DT
cord-104162-fe51v2pt	90	24	three	three	CD
cord-104162-fe51v2pt	90	25	locations	location	NNS
cord-104162-fe51v2pt	90	26	.	.	.
cord-104162-fe51v2pt	91	1	Other	other	JJ
cord-104162-fe51v2pt	91	2	regions	region	NNS
cord-104162-fe51v2pt	91	3	,	,	,
cord-104162-fe51v2pt	91	4	notably	notably	RB
cord-104162-fe51v2pt	91	5	the	the	DT
cord-104162-fe51v2pt	91	6	S	S	NNP
cord-104162-fe51v2pt	91	7	region	region	NN
cord-104162-fe51v2pt	91	8	,	,	,
cord-104162-fe51v2pt	91	9	were	be	VBD
cord-104162-fe51v2pt	91	10	also	also	RB
cord-104162-fe51v2pt	91	11	corroborated	corroborate	VBN
cord-104162-fe51v2pt	91	12	.	.	.
cord-104162-fe51v2pt	92	1	The	the	DT
cord-104162-fe51v2pt	92	2	high	high	JJ
cord-104162-fe51v2pt	92	3	positive	positive	JJ
cord-104162-fe51v2pt	92	4	SI	si	NN
cord-104162-fe51v2pt	92	5	values	value	NNS
cord-104162-fe51v2pt	92	6	,	,	,
cord-104162-fe51v2pt	92	7	indicating	indicate	VBG
cord-104162-fe51v2pt	92	8	regions	region	NNS
cord-104162-fe51v2pt	92	9	likely	likely	JJ
cord-104162-fe51v2pt	92	10	to	to	TO
cord-104162-fe51v2pt	92	11	have	have	VB
cord-104162-fe51v2pt	92	12	poorly	poorly	RB
cord-104162-fe51v2pt	92	13	conserved	conserve	VBN
cord-104162-fe51v2pt	92	14	structures	structure	NNS
cord-104162-fe51v2pt	92	15	,	,	,
cord-104162-fe51v2pt	92	16	are	be	VBP
cord-104162-fe51v2pt	92	17	also	also	RB
cord-104162-fe51v2pt	92	18	corroborated	corroborate	VBN
cord-104162-fe51v2pt	92	19	at	at	IN
cord-104162-fe51v2pt	92	20	some	some	DT
cord-104162-fe51v2pt	92	21	locations	location	NNS
cord-104162-fe51v2pt	92	22	.	.	.
cord-104162-fe51v2pt	93	1	A	a	DT
cord-104162-fe51v2pt	93	2	high	high	JJ
cord-104162-fe51v2pt	93	3	intraspecies	intraspecie	NNS
cord-104162-fe51v2pt	93	4	mutation	mutation	NN
cord-104162-fe51v2pt	93	5	rate	rate	NN
cord-104162-fe51v2pt	93	6	for	for	IN
cord-104162-fe51v2pt	93	7	the	the	DT
cord-104162-fe51v2pt	93	8	N	N	NNP
cord-104162-fe51v2pt	93	9	protein	protein	NN
cord-104162-fe51v2pt	93	10	ORF	ORF	NNP
cord-104162-fe51v2pt	93	11	(	(	-LRB-
cord-104162-fe51v2pt	93	12	Fig	Fig	NNP
cord-104162-fe51v2pt	93	13	.	.	.
cord-104162-fe51v2pt	93	14	3	3	LS
cord-104162-fe51v2pt	93	15	)	)	-RRB-
cord-104162-fe51v2pt	93	16	is	be	VBZ
cord-104162-fe51v2pt	93	17	also	also	RB
cord-104162-fe51v2pt	93	18	seen	see	VBN
cord-104162-fe51v2pt	93	19	when	when	WRB
cord-104162-fe51v2pt	93	20	interspecies	interspecie	NNS
cord-104162-fe51v2pt	93	21	comparisons	comparison	NNS
cord-104162-fe51v2pt	93	22	are	be	VBP
cord-104162-fe51v2pt	93	23	made	make	VBN
cord-104162-fe51v2pt	93	24	with	with	IN
cord-104162-fe51v2pt	93	25	other	other	JJ
cord-104162-fe51v2pt	93	26	coronavirus	coronavirus	NN
cord-104162-fe51v2pt	93	27	species	specie	NNS
cord-104162-fe51v2pt	93	28	,	,	,
cord-104162-fe51v2pt	93	29	with	with	IN
cord-104162-fe51v2pt	93	30	implications	implication	NNS
cord-104162-fe51v2pt	93	31	for	for	IN
cord-104162-fe51v2pt	93	32	early	early	JJ
cord-104162-fe51v2pt	93	33	speciation	speciation	NN
cord-104162-fe51v2pt	93	34	mechanisms	mechanism	NNS
cord-104162-fe51v2pt	93	35	[	[	-LRB-
cord-104162-fe51v2pt	93	36	38	38	CD
cord-104162-fe51v2pt	93	37	]	]	-RRB-
cord-104162-fe51v2pt	93	38	.	.	.
cord-104162-fe51v2pt	94	1	Fig	Fig	NNP
cord-104162-fe51v2pt	94	2	.	.	NNP
cord-104162-fe51v2pt	94	3	4	4	LS
cord-104162-fe51v2pt	94	4	(	(	-LRB-
cord-104162-fe51v2pt	94	5	purple	purple	NNP
cord-104162-fe51v2pt	94	6	)	)	-RRB-
cord-104162-fe51v2pt	94	7	,	,	,
cord-104162-fe51v2pt	94	8	with	with	IN
cord-104162-fe51v2pt	94	9	SI	SI	NNP
cord-104162-fe51v2pt	94	10	indices	index	NNS
cord-104162-fe51v2pt	94	11	for	for	IN
cord-104162-fe51v2pt	94	12	Italy	Italy	NNP
cord-104162-fe51v2pt	94	13	(	(	-LRB-
cord-104162-fe51v2pt	94	14	430	430	CD
cord-104162-fe51v2pt	94	15	isolates	isolate	NNS
cord-104162-fe51v2pt	94	16	;	;	:
cord-104162-fe51v2pt	94	17	green	green	JJ
cord-104162-fe51v2pt	94	18	)	)	-RRB-
cord-104162-fe51v2pt	94	19	and	and	CC
cord-104162-fe51v2pt	94	20	New	New	NNP
cord-104162-fe51v2pt	94	21	York	York	NNP
cord-104162-fe51v2pt	94	22	,	,	,
cord-104162-fe51v2pt	94	23	USA	USA	NNP
cord-104162-fe51v2pt	94	24	(	(	-LRB-
cord-104162-fe51v2pt	94	25	932	932	CD
cord-104162-fe51v2pt	94	26	isolates	isolate	NNS
cord-104162-fe51v2pt	94	27	;	;	:
cord-104162-fe51v2pt	94	28	red	red	JJ
cord-104162-fe51v2pt	94	29	)	)	-RRB-
cord-104162-fe51v2pt	94	30	.	.	.
cord-104162-fe51v2pt	94	31	 	 	_SP
cord-104162-fe51v2pt	95	1	Mutation	mutation	NN
cord-104162-fe51v2pt	95	2	rates	rate	NNS
cord-104162-fe51v2pt	95	3	of	of	IN
cord-104162-fe51v2pt	95	4	microbial	microbial	JJ
cord-104162-fe51v2pt	95	5	pathogens	pathogen	NNS
cord-104162-fe51v2pt	95	6	are	be	VBP
cord-104162-fe51v2pt	95	7	generally	generally	RB
cord-104162-fe51v2pt	95	8	higher	high	JJR
cord-104162-fe51v2pt	95	9	than	than	IN
cord-104162-fe51v2pt	95	10	those	those	DT
cord-104162-fe51v2pt	95	11	of	of	IN
cord-104162-fe51v2pt	95	12	their	-PRON-	PRP$
cord-104162-fe51v2pt	95	13	hosts	host	NNS
cord-104162-fe51v2pt	95	14	.	.	.
cord-104162-fe51v2pt	96	1	While	while	IN
cord-104162-fe51v2pt	96	2	a	a	DT
cord-104162-fe51v2pt	96	3	microbe	microbe	NN
cord-104162-fe51v2pt	96	4	spreading	spread	VBG
cord-104162-fe51v2pt	96	5	from	from	IN
cord-104162-fe51v2pt	96	6	host	host	NN
cord-104162-fe51v2pt	96	7	-	-	HYPH
cord-104162-fe51v2pt	96	8	to	to	IN
cord-104162-fe51v2pt	96	9	-	-	HYPH
cord-104162-fe51v2pt	96	10	host	host	NN
cord-104162-fe51v2pt	96	11	can	can	MD
cord-104162-fe51v2pt	96	12	"	"	``
cord-104162-fe51v2pt	96	13	anticipate	anticipate	VB
cord-104162-fe51v2pt	96	14	"	"	''
cord-104162-fe51v2pt	96	15	that	that	IN
cord-104162-fe51v2pt	96	16	it	-PRON-	PRP
cord-104162-fe51v2pt	96	17	will	will	MD
cord-104162-fe51v2pt	96	18	face	face	VB
cord-104162-fe51v2pt	96	19	a	a	DT
cord-104162-fe51v2pt	96	20	succession	succession	NN
cord-104162-fe51v2pt	96	21	of	of	IN
cord-104162-fe51v2pt	96	22	broadly	broadly	RB
cord-104162-fe51v2pt	96	23	similar	similar	JJ
cord-104162-fe51v2pt	96	24	challenges	challenge	NNS
cord-104162-fe51v2pt	96	25	,	,	,
cord-104162-fe51v2pt	96	26	in	in	IN
cord-104162-fe51v2pt	96	27	the	the	DT
cord-104162-fe51v2pt	96	28	short	short	JJ
cord-104162-fe51v2pt	96	29	-	-	HYPH
cord-104162-fe51v2pt	96	30	term	term	NN
cord-104162-fe51v2pt	96	31	those	those	DT
cord-104162-fe51v2pt	96	32	hosts	host	NNS
cord-104162-fe51v2pt	96	33	can	can	MD
cord-104162-fe51v2pt	96	34	not	not	RB
cord-104162-fe51v2pt	96	35	likewise	likewise	RB
cord-104162-fe51v2pt	96	36	"	"	``
cord-104162-fe51v2pt	96	37	anticipate	anticipate	VB
cord-104162-fe51v2pt	96	38	"	"	''
cord-104162-fe51v2pt	96	39	that	that	DT
cord-104162-fe51v2pt	96	40	new	new	JJ
cord-104162-fe51v2pt	96	41	microbial	microbial	JJ
cord-104162-fe51v2pt	96	42	invaders	invader	NNS
cord-104162-fe51v2pt	96	43	will	will	MD
cord-104162-fe51v2pt	96	44	remain	remain	VB
cord-104162-fe51v2pt	96	45	as	as	IN
cord-104162-fe51v2pt	96	46	they	-PRON-	PRP
cord-104162-fe51v2pt	96	47	were	be	VBD
cord-104162-fe51v2pt	96	48	in	in	IN
cord-104162-fe51v2pt	96	49	previous	previous	JJ
cord-104162-fe51v2pt	96	50	hosts	host	NNS
cord-104162-fe51v2pt	96	51	.	.	.
cord-104162-fe51v2pt	97	1	Thus	thus	RB
cord-104162-fe51v2pt	97	2	,	,	,
cord-104162-fe51v2pt	97	3	host	host	NN
cord-104162-fe51v2pt	97	4	immune	immune	JJ
cord-104162-fe51v2pt	97	5	defenses	defense	NNS
cord-104162-fe51v2pt	97	6	may	may	MD
cord-104162-fe51v2pt	97	7	be	be	VB
cord-104162-fe51v2pt	97	8	overwhelmed	overwhelm	VBN
cord-104162-fe51v2pt	97	9	.	.	.
cord-104162-fe51v2pt	98	1	(	(	-LRB-
cord-104162-fe51v2pt	98	2	In	in	IN
cord-104162-fe51v2pt	98	3	the	the	DT
cord-104162-fe51v2pt	98	4	long	long	JJ
cord-104162-fe51v2pt	98	5	-	-	HYPH
cord-104162-fe51v2pt	98	6	term	term	NN
cord-104162-fe51v2pt	98	7	there	there	EX
cord-104162-fe51v2pt	98	8	is	be	VBZ
cord-104162-fe51v2pt	98	9	a	a	DT
cord-104162-fe51v2pt	98	10	different	different	JJ
cord-104162-fe51v2pt	98	11	scenario	scenario	NN
cord-104162-fe51v2pt	98	12	related	relate	VBN
cord-104162-fe51v2pt	98	13	to	to	IN
cord-104162-fe51v2pt	98	14	innate	innate	JJ
cord-104162-fe51v2pt	98	15	immunity	immunity	NN
cord-104162-fe51v2pt	98	16	;	;	:
cord-104162-fe51v2pt	98	17	see	see	VB
cord-104162-fe51v2pt	98	18	below	below	RB
cord-104162-fe51v2pt	98	19	)	)	-RRB-
cord-104162-fe51v2pt	98	20	.	.	.
cord-104162-fe51v2pt	99	1	Therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	99	2	challenges	challenge	NNS
cord-104162-fe51v2pt	99	3	are	be	VBP
cord-104162-fe51v2pt	99	4	,	,	,
cord-104162-fe51v2pt	99	5	first	first	RB
cord-104162-fe51v2pt	99	6	,	,	,
cord-104162-fe51v2pt	99	7	to	to	TO
cord-104162-fe51v2pt	99	8	locate	locate	VB
cord-104162-fe51v2pt	99	9	a	a	DT
cord-104162-fe51v2pt	99	10	conserved	conserve	VBN
cord-104162-fe51v2pt	99	11	,	,	,
cord-104162-fe51v2pt	99	12	less	less	RBR
cord-104162-fe51v2pt	99	13	-	-	HYPH
cord-104162-fe51v2pt	99	14	variable	variable	NN
cord-104162-fe51v2pt	99	15	,	,	,
cord-104162-fe51v2pt	99	16	part	part	NN
cord-104162-fe51v2pt	99	17	of	of	IN
cord-104162-fe51v2pt	99	18	a	a	DT
cord-104162-fe51v2pt	99	19	pathogen	pathogen	NN
cord-104162-fe51v2pt	99	20	's	's	POS
cord-104162-fe51v2pt	99	21	genome	genome	NN
cord-104162-fe51v2pt	99	22	that	that	IN
cord-104162-fe51v2pt	99	23	it	-PRON-	PRP
cord-104162-fe51v2pt	99	24	will	will	MD
cord-104162-fe51v2pt	99	25	have	have	VB
cord-104162-fe51v2pt	99	26	inherited	inherit	VBN
cord-104162-fe51v2pt	99	27	sequentially	sequentially	RB
cord-104162-fe51v2pt	99	28	from	from	IN
cord-104162-fe51v2pt	99	29	a	a	DT
cord-104162-fe51v2pt	99	30	multiplicity	multiplicity	NN
cord-104162-fe51v2pt	99	31	of	of	IN
cord-104162-fe51v2pt	99	32	past	past	JJ
cord-104162-fe51v2pt	99	33	generations	generation	NNS
cord-104162-fe51v2pt	99	34	,	,	,
cord-104162-fe51v2pt	99	35	and	and	CC
cord-104162-fe51v2pt	99	36	so	so	RB
cord-104162-fe51v2pt	99	37	is	be	VBZ
cord-104162-fe51v2pt	99	38	likely	likely	JJ
cord-104162-fe51v2pt	99	39	to	to	TO
cord-104162-fe51v2pt	99	40	carry	carry	VB
cord-104162-fe51v2pt	99	41	through	through	RP
cord-104162-fe51v2pt	99	42	to	to	IN
cord-104162-fe51v2pt	99	43	a	a	DT
cord-104162-fe51v2pt	99	44	multiplicity	multiplicity	NN
cord-104162-fe51v2pt	99	45	of	of	IN
cord-104162-fe51v2pt	99	46	future	future	JJ
cord-104162-fe51v2pt	99	47	generations	generation	NNS
cord-104162-fe51v2pt	99	48	.	.	.
cord-104162-fe51v2pt	100	1	Second	second	RB
cord-104162-fe51v2pt	100	2	,	,	,
cord-104162-fe51v2pt	100	3	is	be	VBZ
cord-104162-fe51v2pt	100	4	to	to	TO
cord-104162-fe51v2pt	100	5	identify	identify	VB
cord-104162-fe51v2pt	100	6	the	the	DT
cord-104162-fe51v2pt	100	7	corresponding	corresponding	JJ
cord-104162-fe51v2pt	100	8	primary	primary	JJ
cord-104162-fe51v2pt	100	9	function	function	NN
cord-104162-fe51v2pt	100	10	,	,	,
cord-104162-fe51v2pt	100	11	be	be	VB
cord-104162-fe51v2pt	100	12	it	-PRON-	PRP
cord-104162-fe51v2pt	100	13	at	at	IN
cord-104162-fe51v2pt	100	14	the	the	DT
cord-104162-fe51v2pt	100	15	genome	genome	NN
cord-104162-fe51v2pt	100	16	,	,	,
cord-104162-fe51v2pt	100	17	RNA	RNA	NNP
cord-104162-fe51v2pt	100	18	transcript	transcript	NN
cord-104162-fe51v2pt	100	19	,	,	,
cord-104162-fe51v2pt	100	20	or	or	CC
cord-104162-fe51v2pt	100	21	protein	protein	NN
cord-104162-fe51v2pt	100	22	level	level	NN
cord-104162-fe51v2pt	100	23	.	.	.
cord-104162-fe51v2pt	101	1	Third	third	RB
cord-104162-fe51v2pt	101	2	,	,	,
cord-104162-fe51v2pt	101	3	from	from	IN
cord-104162-fe51v2pt	101	4	this	this	DT
cord-104162-fe51v2pt	101	5	knowledge	knowledge	NN
cord-104162-fe51v2pt	101	6	(	(	-LRB-
cord-104162-fe51v2pt	101	7	that	that	DT
cord-104162-fe51v2pt	101	8	may	may	MD
cord-104162-fe51v2pt	101	9	be	be	VB
cord-104162-fe51v2pt	101	10	incomplete	incomplete	JJ
cord-104162-fe51v2pt	101	11	;	;	:
cord-104162-fe51v2pt	101	12	i.e.	i.e.	FW
cord-104162-fe51v2pt	101	13	function	function	NN
cord-104162-fe51v2pt	101	14	not	not	RB
cord-104162-fe51v2pt	101	15	fully	fully	RB
cord-104162-fe51v2pt	101	16	clarified	clarify	VBN
cord-104162-fe51v2pt	101	17	)	)	-RRB-
cord-104162-fe51v2pt	101	18	,	,	,
cord-104162-fe51v2pt	101	19	devise	devise	VB
cord-104162-fe51v2pt	101	20	effective	effective	JJ
cord-104162-fe51v2pt	101	21	pathogen	pathogen	NN
cord-104162-fe51v2pt	101	22	inhibition	inhibition	NN
cord-104162-fe51v2pt	101	23	without	without	IN
cord-104162-fe51v2pt	101	24	imposing	impose	VBG
cord-104162-fe51v2pt	101	25	deleterious	deleterious	JJ
cord-104162-fe51v2pt	101	26	side	side	NN
cord-104162-fe51v2pt	101	27	-	-	HYPH
cord-104162-fe51v2pt	101	28	effects	effect	NNS
cord-104162-fe51v2pt	101	29	on	on	IN
cord-104162-fe51v2pt	101	30	the	the	DT
cord-104162-fe51v2pt	101	31	host	host	NN
cord-104162-fe51v2pt	101	32	.	.	.
cord-104162-fe51v2pt	102	1	Viral	viral	JJ
cord-104162-fe51v2pt	102	2	vulnerability	vulnerability	NN
cord-104162-fe51v2pt	102	3	is	be	VBZ
cord-104162-fe51v2pt	102	4	often	often	RB
cord-104162-fe51v2pt	102	5	assumed	assume	VBN
cord-104162-fe51v2pt	102	6	to	to	TO
cord-104162-fe51v2pt	102	7	associate	associate	VB
cord-104162-fe51v2pt	102	8	with	with	IN
cord-104162-fe51v2pt	102	9	protein	protein	NN
cord-104162-fe51v2pt	102	10	-	-	HYPH
cord-104162-fe51v2pt	102	11	level	level	NN
cord-104162-fe51v2pt	102	12	functions	function	NNS
cord-104162-fe51v2pt	102	13	[	[	-LRB-
cord-104162-fe51v2pt	102	14	11	11	CD
cord-104162-fe51v2pt	102	15	,	,	,
cord-104162-fe51v2pt	102	16	12	12	CD
cord-104162-fe51v2pt	102	17	]	]	-RRB-
cord-104162-fe51v2pt	102	18	.	.	.
cord-104162-fe51v2pt	103	1	However	however	RB
cord-104162-fe51v2pt	103	2	,	,	,
cord-104162-fe51v2pt	103	3	studies	study	NNS
cord-104162-fe51v2pt	103	4	of	of	IN
cord-104162-fe51v2pt	103	5	the	the	DT
cord-104162-fe51v2pt	103	6	AIDS	AIDS	NNP
cord-104162-fe51v2pt	103	7	virus	virus	NN
cord-104162-fe51v2pt	103	8	have	have	VBP
cord-104162-fe51v2pt	103	9	identified	identify	VBN
cord-104162-fe51v2pt	103	10	genome	genome	NN
cord-104162-fe51v2pt	103	11	structure	structure	NN
cord-104162-fe51v2pt	103	12	itself	-PRON-	PRP
cord-104162-fe51v2pt	103	13	as	as	IN
cord-104162-fe51v2pt	103	14	both	both	CC
cord-104162-fe51v2pt	103	15	functional	functional	JJ
cord-104162-fe51v2pt	103	16	and	and	CC
cord-104162-fe51v2pt	103	17	conserved	conserved	JJ
cord-104162-fe51v2pt	103	18	,	,	,
cord-104162-fe51v2pt	103	19	so	so	RB
cord-104162-fe51v2pt	103	20	signifying	signify	VBG
cord-104162-fe51v2pt	103	21	vulnerability	vulnerability	NN
cord-104162-fe51v2pt	103	22	[	[	-LRB-
cord-104162-fe51v2pt	103	23	2	2	CD
cord-104162-fe51v2pt	103	24	,	,	,
cord-104162-fe51v2pt	103	25	3	3	CD
cord-104162-fe51v2pt	103	26	]	]	-RRB-
cord-104162-fe51v2pt	103	27	(	(	-LRB-
cord-104162-fe51v2pt	103	28	see	see	VB
cord-104162-fe51v2pt	103	29	Fig	Fig	NNP
cord-104162-fe51v2pt	103	30	.	.	NNP
cord-104162-fe51v2pt	103	31	1	1	CD
cord-104162-fe51v2pt	103	32	)	)	-RRB-
cord-104162-fe51v2pt	103	33	.	.	.
cord-104162-fe51v2pt	104	1	A	a	DT
cord-104162-fe51v2pt	104	2	genomic	genomic	JJ
cord-104162-fe51v2pt	104	3	packaging	packaging	NN
cord-104162-fe51v2pt	104	4	signal	signal	NN
cord-104162-fe51v2pt	104	5	for	for	IN
cord-104162-fe51v2pt	104	6	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	104	7	,	,	,
cord-104162-fe51v2pt	104	8	which	which	WDT
cord-104162-fe51v2pt	104	9	is	be	VBZ
cord-104162-fe51v2pt	104	10	specifically	specifically	RB
cord-104162-fe51v2pt	104	11	recognized	recognize	VBN
cord-104162-fe51v2pt	104	12	by	by	IN
cord-104162-fe51v2pt	104	13	the	the	DT
cord-104162-fe51v2pt	104	14	nucleocapsid	nucleocapsid	NNP
cord-104162-fe51v2pt	104	15	domain	domain	NN
cord-104162-fe51v2pt	104	16	of	of	IN
cord-104162-fe51v2pt	104	17	its	-PRON-	PRP$
cord-104162-fe51v2pt	104	18	Gag	Gag	NNP
cord-104162-fe51v2pt	104	19	polyprotein	polyprotein	NN
cord-104162-fe51v2pt	104	20	,	,	,
cord-104162-fe51v2pt	104	21	has	have	VBZ
cord-104162-fe51v2pt	104	22	long	long	RB
cord-104162-fe51v2pt	104	23	been	be	VBN
cord-104162-fe51v2pt	104	24	recognized	recognize	VBN
cord-104162-fe51v2pt	104	25	as	as	IN
cord-104162-fe51v2pt	104	26	a	a	DT
cord-104162-fe51v2pt	104	27	potential	potential	JJ
cord-104162-fe51v2pt	104	28	"	"	``
cord-104162-fe51v2pt	104	29	Achilles	Achilles	NNP
cord-104162-fe51v2pt	104	30	heel	heel	NN
cord-104162-fe51v2pt	104	31	"	"	''
cord-104162-fe51v2pt	104	32	[	[	-LRB-
cord-104162-fe51v2pt	104	33	2	2	CD
cord-104162-fe51v2pt	104	34	,	,	,
cord-104162-fe51v2pt	104	35	3	3	CD
cord-104162-fe51v2pt	104	36	,	,	,
cord-104162-fe51v2pt	104	37	7	7	CD
cord-104162-fe51v2pt	104	38	]	]	-RRB-
cord-104162-fe51v2pt	104	39	so	so	RB
cord-104162-fe51v2pt	104	40	inviting	invite	VBG
cord-104162-fe51v2pt	104	41	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	104	42	exploration	exploration	NN
cord-104162-fe51v2pt	104	43	[	[	-LRB-
cord-104162-fe51v2pt	104	44	4	4	CD
cord-104162-fe51v2pt	104	45	]	]	-RRB-
cord-104162-fe51v2pt	104	46	[	[	-LRB-
cord-104162-fe51v2pt	104	47	5	5	CD
cord-104162-fe51v2pt	104	48	]	]	-RRB-
cord-104162-fe51v2pt	104	49	[	[	-LRB-
cord-104162-fe51v2pt	104	50	6	6	CD
cord-104162-fe51v2pt	104	51	]	]	-RRB-
cord-104162-fe51v2pt	104	52	.	.	.
cord-104162-fe51v2pt	105	1	Through	through	IN
cord-104162-fe51v2pt	105	2	targeting	target	VBG
cord-104162-fe51v2pt	105	3	of	of	IN
cord-104162-fe51v2pt	105	4	specific	specific	JJ
cord-104162-fe51v2pt	105	5	RNA	RNA	NNP
cord-104162-fe51v2pt	105	6	conformations	conformation	NNS
cord-104162-fe51v2pt	105	7	,	,	,
cord-104162-fe51v2pt	105	8	Gag	gag	VB
cord-104162-fe51v2pt	105	9	not	not	RB
cord-104162-fe51v2pt	105	10	only	only	RB
cord-104162-fe51v2pt	105	11	influences	influence	VBZ
cord-104162-fe51v2pt	105	12	the	the	DT
cord-104162-fe51v2pt	105	13	assembly	assembly	NN
cord-104162-fe51v2pt	105	14	of	of	IN
cord-104162-fe51v2pt	105	15	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	105	16	genomic	genomic	JJ
cord-104162-fe51v2pt	105	17	RNA	RNA	NNP
cord-104162-fe51v2pt	105	18	into	into	IN
cord-104162-fe51v2pt	105	19	virus	virus	NN
cord-104162-fe51v2pt	105	20	particles	particle	NNS
cord-104162-fe51v2pt	105	21	,	,	,
cord-104162-fe51v2pt	105	22	but	but	CC
cord-104162-fe51v2pt	105	23	also	also	RB
cord-104162-fe51v2pt	105	24	regulates	regulate	VBZ
cord-104162-fe51v2pt	105	25	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	105	26	mRNA	mrna	NN
cord-104162-fe51v2pt	105	27	translation	translation	NN
cord-104162-fe51v2pt	105	28	[	[	-LRB-
cord-104162-fe51v2pt	105	29	39	39	CD
cord-104162-fe51v2pt	105	30	]	]	-RRB-
cord-104162-fe51v2pt	105	31	.	.	.
cord-104162-fe51v2pt	106	1	permit	permit	VB
cord-104162-fe51v2pt	106	2	easier	easy	JJR
cord-104162-fe51v2pt	106	3	switching	switch	VBG
cord-104162-fe51v2pt	106	4	between	between	IN
cord-104162-fe51v2pt	106	5	regulatory	regulatory	JJ
cord-104162-fe51v2pt	106	6	options	option	NNS
cord-104162-fe51v2pt	106	7	.	.	.
cord-104162-fe51v2pt	107	1	Indeed	indeed	RB
cord-104162-fe51v2pt	107	2	,	,	,
cord-104162-fe51v2pt	107	3	small	small	JJ
cord-104162-fe51v2pt	107	4	changes	change	NNS
cord-104162-fe51v2pt	107	5	in	in	IN
cord-104162-fe51v2pt	107	6	target	target	NN
cord-104162-fe51v2pt	107	7	RNA	RNA	NNP
cord-104162-fe51v2pt	107	8	structure	structure	NN
cord-104162-fe51v2pt	107	9	can	can	MD
cord-104162-fe51v2pt	107	10	impede	impede	VB
cord-104162-fe51v2pt	107	11	this	this	DT
cord-104162-fe51v2pt	107	12	[	[	-LRB-
cord-104162-fe51v2pt	107	13	6	6	CD
cord-104162-fe51v2pt	107	14	]	]	-RRB-
cord-104162-fe51v2pt	107	15	.	.	.
cord-104162-fe51v2pt	108	1	Thus	thus	RB
cord-104162-fe51v2pt	108	2	,	,	,
cord-104162-fe51v2pt	108	3	unlike	unlike	IN
cord-104162-fe51v2pt	108	4	most	most	JJS
cord-104162-fe51v2pt	108	5	other	other	JJ
cord-104162-fe51v2pt	108	6	regions	region	NNS
cord-104162-fe51v2pt	108	7	of	of	IN
cord-104162-fe51v2pt	108	8	the	the	DT
cord-104162-fe51v2pt	108	9	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	108	10	genome	genome	NN
cord-104162-fe51v2pt	108	11	,	,	,
cord-104162-fe51v2pt	108	12	mutations	mutation	NNS
cord-104162-fe51v2pt	108	13	here	here	RB
cord-104162-fe51v2pt	108	14	would	would	MD
cord-104162-fe51v2pt	108	15	likely	likely	RB
cord-104162-fe51v2pt	108	16	lead	lead	VB
cord-104162-fe51v2pt	108	17	to	to	IN
cord-104162-fe51v2pt	108	18	negative	negative	JJ
cord-104162-fe51v2pt	108	19	Darwinian	darwinian	JJ
cord-104162-fe51v2pt	108	20	selection	selection	NN
cord-104162-fe51v2pt	108	21	at	at	IN
cord-104162-fe51v2pt	108	22	an	an	DT
cord-104162-fe51v2pt	108	23	early	early	JJ
cord-104162-fe51v2pt	108	24	stage	stage	NN
cord-104162-fe51v2pt	109	1	-hence	-hence	:
cord-104162-fe51v2pt	110	1	the	the	DT
cord-104162-fe51v2pt	110	2	high	high	JJ
cord-104162-fe51v2pt	110	3	conservation	conservation	NN
cord-104162-fe51v2pt	110	4	.	.	.
cord-104162-fe51v2pt	111	1	Application	application	NN
cord-104162-fe51v2pt	111	2	of	of	IN
cord-104162-fe51v2pt	111	3	the	the	DT
cord-104162-fe51v2pt	111	4	same	same	JJ
cord-104162-fe51v2pt	111	5	bioinformatic	bioinformatic	JJ
cord-104162-fe51v2pt	111	6	technology	technology	NN
cord-104162-fe51v2pt	111	7	to	to	IN
cord-104162-fe51v2pt	111	8	the	the	DT
cord-104162-fe51v2pt	111	9	SARS	SARS	NNP
cord-104162-fe51v2pt	111	10	-	-	HYPH
cord-104162-fe51v2pt	111	11	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	111	12	virus	virus	NN
cord-104162-fe51v2pt	111	13	genome	genome	NN
cord-104162-fe51v2pt	111	14	has	have	VBZ
cord-104162-fe51v2pt	111	15	now	now	RB
cord-104162-fe51v2pt	111	16	revealed	reveal	VBN
cord-104162-fe51v2pt	111	17	similar	similar	JJ
cord-104162-fe51v2pt	111	18	"	"	``
cord-104162-fe51v2pt	111	19	Achilles	Achilles	NNP
cord-104162-fe51v2pt	111	20	heels	heel	NNS
cord-104162-fe51v2pt	111	21	.	.	.
cord-104162-fe51v2pt	112	1	"	"	''
cord-104162-fe51v2pt	113	1	1	1	CD
cord-104162-fe51v2pt	113	2	4	4	CD
cord-104162-fe51v2pt	113	3	Lacking	lack	VBG
cord-104162-fe51v2pt	113	4	the	the	DT
cord-104162-fe51v2pt	113	5	chronicity	chronicity	NN
cord-104162-fe51v2pt	113	6	of	of	IN
cord-104162-fe51v2pt	113	7	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	113	8	infection	infection	NN
cord-104162-fe51v2pt	113	9	,	,	,
cord-104162-fe51v2pt	113	10	the	the	DT
cord-104162-fe51v2pt	113	11	genome	genome	NN
cord-104162-fe51v2pt	113	12	of	of	IN
cord-104162-fe51v2pt	113	13	SARS	SARS	NNP
cord-104162-fe51v2pt	113	14	-	-	HYPH
cord-104162-fe51v2pt	113	15	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	113	16	should	should	MD
cord-104162-fe51v2pt	113	17	have	have	VB
cord-104162-fe51v2pt	113	18	been	be	VBN
cord-104162-fe51v2pt	113	19	shaped	shape	VBN
cord-104162-fe51v2pt	113	20	less	less	JJR
cord-104162-fe51v2pt	113	21	by	by	IN
cord-104162-fe51v2pt	113	22	adaptations	adaptation	NNS
cord-104162-fe51v2pt	113	23	to	to	TO
cord-104162-fe51v2pt	113	24	counter	counter	VB
cord-104162-fe51v2pt	113	25	long	long	JJ
cord-104162-fe51v2pt	113	26	-	-	HYPH
cord-104162-fe51v2pt	113	27	term	term	NN
cord-104162-fe51v2pt	113	28	host	host	NN
cord-104162-fe51v2pt	113	29	immune	immune	JJ
cord-104162-fe51v2pt	113	30	defenses	defense	NNS
cord-104162-fe51v2pt	113	31	.	.	.
cord-104162-fe51v2pt	114	1	It	-PRON-	PRP
cord-104162-fe51v2pt	114	2	can	can	MD
cord-104162-fe51v2pt	114	3	not	not	RB
cord-104162-fe51v2pt	114	4	hide	hide	VB
cord-104162-fe51v2pt	114	5	within	within	IN
cord-104162-fe51v2pt	114	6	its	-PRON-	PRP$
cord-104162-fe51v2pt	114	7	host	host	NN
cord-104162-fe51v2pt	114	8	genome	genome	NN
cord-104162-fe51v2pt	114	9	in	in	IN
cord-104162-fe51v2pt	114	10	latent	latent	JJ
cord-104162-fe51v2pt	114	11	DNA	dna	NN
cord-104162-fe51v2pt	114	12	form	form	NN
cord-104162-fe51v2pt	114	13	.	.	.
cord-104162-fe51v2pt	115	1	Yet	yet	RB
cord-104162-fe51v2pt	115	2	,	,	,
cord-104162-fe51v2pt	115	3	the	the	DT
cord-104162-fe51v2pt	115	4	larger	large	JJR
cord-104162-fe51v2pt	115	5	SARS	SARS	NNP
cord-104162-fe51v2pt	115	6	-	-	HYPH
cord-104162-fe51v2pt	115	7	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	115	8	genome	genome	NN
cord-104162-fe51v2pt	115	9	contains	contain	VBZ
cord-104162-fe51v2pt	115	10	many	many	JJ
cord-104162-fe51v2pt	115	11	more	more	JJR
cord-104162-fe51v2pt	115	12	genes	gene	NNS
cord-104162-fe51v2pt	115	13	than	than	IN
cord-104162-fe51v2pt	115	14	HIV	HIV	NNP
cord-104162-fe51v2pt	115	15	,	,	,
cord-104162-fe51v2pt	115	16	which	which	WDT
cord-104162-fe51v2pt	115	17	require	require	VBP
cord-104162-fe51v2pt	115	18	differential	differential	JJ
cord-104162-fe51v2pt	115	19	expression	expression	NN
cord-104162-fe51v2pt	115	20	according	accord	VBG
cord-104162-fe51v2pt	115	21	to	to	IN
cord-104162-fe51v2pt	115	22	the	the	DT
cord-104162-fe51v2pt	115	23	stage	stage	NN
cord-104162-fe51v2pt	115	24	of	of	IN
cord-104162-fe51v2pt	115	25	infection	infection	NN
cord-104162-fe51v2pt	115	26	.	.	.
cord-104162-fe51v2pt	116	1	Even	even	RB
cord-104162-fe51v2pt	116	2	more	more	RBR
cord-104162-fe51v2pt	116	3	complex	complex	JJ
cord-104162-fe51v2pt	116	4	regulatory	regulatory	JJ
cord-104162-fe51v2pt	116	5	controls	control	NNS
cord-104162-fe51v2pt	116	6	can	can	MD
cord-104162-fe51v2pt	116	7	be	be	VB
cord-104162-fe51v2pt	116	8	envisaged	envisage	VBN
cord-104162-fe51v2pt	116	9	,	,	,
cord-104162-fe51v2pt	116	10	likely	likely	RB
cord-104162-fe51v2pt	116	11	requiring	require	VBG
cord-104162-fe51v2pt	116	12	conserved	conserve	VBN
cord-104162-fe51v2pt	116	13	genome	genome	NN
cord-104162-fe51v2pt	116	14	conformations	conformation	NNS
cord-104162-fe51v2pt	116	15	at	at	IN
cord-104162-fe51v2pt	116	16	appropriate	appropriate	JJ
cord-104162-fe51v2pt	116	17	locations	location	NNS
cord-104162-fe51v2pt	116	18	.	.	.
cord-104162-fe51v2pt	117	1	Be	be	VB
cord-104162-fe51v2pt	117	2	they	-PRON-	PRP
cord-104162-fe51v2pt	117	3	synonymous	synonymous	JJ
cord-104162-fe51v2pt	117	4	or	or	CC
cord-104162-fe51v2pt	117	5	non	non	JJ
cord-104162-fe51v2pt	117	6	-	-	JJ
cord-104162-fe51v2pt	117	7	synonymous	synonymous	JJ
cord-104162-fe51v2pt	117	8	,	,	,
cord-104162-fe51v2pt	117	9	mutations	mutation	NNS
cord-104162-fe51v2pt	117	10	in	in	IN
cord-104162-fe51v2pt	117	11	these	these	DT
cord-104162-fe51v2pt	117	12	structured	structured	JJ
cord-104162-fe51v2pt	117	13	regions	region	NNS
cord-104162-fe51v2pt	117	14	could	could	MD
cord-104162-fe51v2pt	117	15	result	result	VB
cord-104162-fe51v2pt	117	16	in	in	IN
cord-104162-fe51v2pt	117	17	negative	negative	JJ
cord-104162-fe51v2pt	117	18	selection	selection	NN
cord-104162-fe51v2pt	117	19	of	of	IN
cord-104162-fe51v2pt	117	20	the	the	DT
cord-104162-fe51v2pt	117	21	viruses	virus	NNS
cord-104162-fe51v2pt	117	22	in	in	IN
cord-104162-fe51v2pt	117	23	which	which	WDT
cord-104162-fe51v2pt	117	24	they	-PRON-	PRP
cord-104162-fe51v2pt	117	25	occurredhence	occurredhence	VBP
cord-104162-fe51v2pt	117	26	high	high	JJ
cord-104162-fe51v2pt	117	27	conservation	conservation	NN
cord-104162-fe51v2pt	117	28	.	.	.
cord-104162-fe51v2pt	118	1	The	the	DT
cord-104162-fe51v2pt	118	2	ribosome	ribosome	NN
cord-104162-fe51v2pt	118	3	FSE	FSE	NNP
cord-104162-fe51v2pt	118	4	located	locate	VBD
cord-104162-fe51v2pt	118	5	close	close	RB
cord-104162-fe51v2pt	118	6	to	to	IN
cord-104162-fe51v2pt	118	7	base	base	NN
cord-104162-fe51v2pt	118	8	13468	13468	CD
cord-104162-fe51v2pt	119	1	(	(	-LRB-
cord-104162-fe51v2pt	119	2	Figs	fig	NNS
cord-104162-fe51v2pt	119	3	.	.	.
cord-104162-fe51v2pt	119	4	2	2	LS
cord-104162-fe51v2pt	119	5	)	)	-RRB-
cord-104162-fe51v2pt	119	6	would	would	MD
cord-104162-fe51v2pt	119	7	seem	seem	VB
cord-104162-fe51v2pt	119	8	to	to	TO
cord-104162-fe51v2pt	119	9	exemplify	exemplify	VB
cord-104162-fe51v2pt	119	10	this	this	DT
cord-104162-fe51v2pt	119	11	[	[	-LRB-
cord-104162-fe51v2pt	119	12	13	13	CD
cord-104162-fe51v2pt	119	13	]	]	-RRB-
cord-104162-fe51v2pt	119	14	,	,	,
cord-104162-fe51v2pt	119	15	and	and	CC
cord-104162-fe51v2pt	119	16	a	a	DT
cord-104162-fe51v2pt	119	17	potential	potential	JJ
cord-104162-fe51v2pt	119	18	targeting	target	VBG
cord-104162-fe51v2pt	119	19	agent	agent	NN
cord-104162-fe51v2pt	119	20	is	be	VBZ
cord-104162-fe51v2pt	119	21	now	now	RB
cord-104162-fe51v2pt	119	22	available	available	JJ
cord-104162-fe51v2pt	119	23	[	[	-LRB-
cord-104162-fe51v2pt	119	24	10	10	CD
cord-104162-fe51v2pt	119	25	]	]	-RRB-
cord-104162-fe51v2pt	119	26	.	.	.
cord-104162-fe51v2pt	120	1	However	however	RB
cord-104162-fe51v2pt	120	2	,	,	,
cord-104162-fe51v2pt	120	3	we	-PRON-	PRP
cord-104162-fe51v2pt	120	4	have	have	VBP
cord-104162-fe51v2pt	120	5	here	here	RB
cord-104162-fe51v2pt	120	6	identified	identify	VBN
cord-104162-fe51v2pt	120	7	other	other	JJ
cord-104162-fe51v2pt	120	8	structurally	structurally	RB
cord-104162-fe51v2pt	120	9	important	important	JJ
cord-104162-fe51v2pt	120	10	regions	region	NNS
cord-104162-fe51v2pt	120	11	with	with	IN
cord-104162-fe51v2pt	120	12	more	more	JJR
cord-104162-fe51v2pt	120	13	base	base	NN
cord-104162-fe51v2pt	120	14	order	order	NN
cord-104162-fe51v2pt	120	15	-	-	HYPH
cord-104162-fe51v2pt	120	16	dependence	dependence	NN
cord-104162-fe51v2pt	120	17	and	and	CC
cord-104162-fe51v2pt	120	18	higher	high	JJR
cord-104162-fe51v2pt	120	19	degrees	degree	NNS
cord-104162-fe51v2pt	120	20	of	of	IN
cord-104162-fe51v2pt	120	21	conservation	conservation	NN
cord-104162-fe51v2pt	121	1	(	(	-LRB-
cord-104162-fe51v2pt	121	2	Figs	Figs	NNP
cord-104162-fe51v2pt	121	3	3	3	CD
cord-104162-fe51v2pt	121	4	-	-	SYM
cord-104162-fe51v2pt	121	5	5	5	CD
cord-104162-fe51v2pt	121	6	)	)	-RRB-
cord-104162-fe51v2pt	121	7	,	,	,
cord-104162-fe51v2pt	121	8	that	that	DT
cord-104162-fe51v2pt	121	9	might	may	MD
cord-104162-fe51v2pt	121	10	,	,	,
cord-104162-fe51v2pt	121	11	either	either	CC
cord-104162-fe51v2pt	121	12	singly	singly	RB
cord-104162-fe51v2pt	121	13	or	or	CC
cord-104162-fe51v2pt	121	14	collectively	collectively	RB
cord-104162-fe51v2pt	121	15	,	,	,
cord-104162-fe51v2pt	121	16	be	be	VB
cord-104162-fe51v2pt	121	17	better	well	JJR
cord-104162-fe51v2pt	121	18	candidates	candidate	NNS
cord-104162-fe51v2pt	121	19	for	for	IN
cord-104162-fe51v2pt	121	20	targeting	target	VBG
cord-104162-fe51v2pt	121	21	.	.	.
cord-104162-fe51v2pt	122	1	When	when	WRB
cord-104162-fe51v2pt	122	2	determining	determine	VBG
cord-104162-fe51v2pt	122	3	folding	fold	VBG
cord-104162-fe51v2pt	122	4	energy	energy	NN
cord-104162-fe51v2pt	122	5	,	,	,
cord-104162-fe51v2pt	122	6	our	-PRON-	PRP$
cord-104162-fe51v2pt	122	7	approach	approach	NN
cord-104162-fe51v2pt	122	8	depends	depend	VBZ
cord-104162-fe51v2pt	122	9	on	on	IN
cord-104162-fe51v2pt	122	10	eliminating	eliminate	VBG
cord-104162-fe51v2pt	122	11	contributions	contribution	NNS
cord-104162-fe51v2pt	122	12	of	of	IN
cord-104162-fe51v2pt	122	13	base	base	NN
cord-104162-fe51v2pt	122	14	composition	composition	NN
cord-104162-fe51v2pt	122	15	which	which	WDT
cord-104162-fe51v2pt	122	16	,	,	,
cord-104162-fe51v2pt	122	17	as	as	IN
cord-104162-fe51v2pt	122	18	noted	note	VBN
cord-104162-fe51v2pt	122	19	,	,	,
cord-104162-fe51v2pt	122	20	plays	play	VBZ
cord-104162-fe51v2pt	122	21	an	an	DT
cord-104162-fe51v2pt	122	22	unusual	unusual	JJ
cord-104162-fe51v2pt	122	23	role	role	NN
cord-104162-fe51v2pt	122	24	in	in	IN
cord-104162-fe51v2pt	122	25	the	the	DT
cord-104162-fe51v2pt	122	26	case	case	NN
cord-104162-fe51v2pt	122	27	of	of	IN
cord-104162-fe51v2pt	122	28	the	the	DT
cord-104162-fe51v2pt	122	29	FSE	FSE	NNP
cord-104162-fe51v2pt	122	30	.	.	.
cord-104162-fe51v2pt	123	1	More	more	RBR
cord-104162-fe51v2pt	123	2	usually	usually	RB
cord-104162-fe51v2pt	123	3	,	,	,
cord-104162-fe51v2pt	123	4	base	base	NN
cord-104162-fe51v2pt	123	5	composition	composition	NN
cord-104162-fe51v2pt	123	6	is	be	VBZ
cord-104162-fe51v2pt	123	7	a	a	DT
cord-104162-fe51v2pt	123	8	distinctive	distinctive	JJ
cord-104162-fe51v2pt	123	9	characteristic	characteristic	NN
cord-104162-fe51v2pt	123	10	of	of	IN
cord-104162-fe51v2pt	123	11	entire	entire	JJ
cord-104162-fe51v2pt	123	12	genomes	genome	NNS
cord-104162-fe51v2pt	123	13	or	or	CC
cord-104162-fe51v2pt	123	14	large	large	JJ
cord-104162-fe51v2pt	123	15	genome	genome	NN
cord-104162-fe51v2pt	123	16	sectors	sector	NNS
cord-104162-fe51v2pt	123	17	that	that	WDT
cord-104162-fe51v2pt	123	18	reflects	reflect	VBZ
cord-104162-fe51v2pt	123	19	their	-PRON-	PRP$
cord-104162-fe51v2pt	123	20	underlying	underlie	VBG
cord-104162-fe51v2pt	123	21	oligomer	oligomer	NN
cord-104162-fe51v2pt	123	22	(	(	-LRB-
cord-104162-fe51v2pt	123	23	"	"	``
cord-104162-fe51v2pt	123	24	k	k	NNP
cord-104162-fe51v2pt	123	25	-	-	HYPH
cord-104162-fe51v2pt	123	26	mer	mer	NNP
cord-104162-fe51v2pt	123	27	"	"	''
cord-104162-fe51v2pt	123	28	)	)	-RRB-
cord-104162-fe51v2pt	123	29	content	content	NN
cord-104162-fe51v2pt	123	30	.	.	.
cord-104162-fe51v2pt	124	1	The	the	DT
cord-104162-fe51v2pt	124	2	slow	slow	JJ
cord-104162-fe51v2pt	124	3	genome	genome	NN
cord-104162-fe51v2pt	124	4	-	-	HYPH
cord-104162-fe51v2pt	124	5	wide	wide	JJ
cord-104162-fe51v2pt	124	6	accumulation	accumulation	NN
cord-104162-fe51v2pt	124	7	of	of	IN
cord-104162-fe51v2pt	124	8	mutations	mutation	NNS
cord-104162-fe51v2pt	124	9	in	in	IN
cord-104162-fe51v2pt	124	10	oligomer	oligomer	NNP
cord-104162-fe51v2pt	124	11	composition	composition	NN
cord-104162-fe51v2pt	124	12	(	(	-LRB-
cord-104162-fe51v2pt	124	13	easiest	easy	JJS
cord-104162-fe51v2pt	124	14	documented	document	VBN
cord-104162-fe51v2pt	124	15	as	as	IN
cord-104162-fe51v2pt	124	16	changes	change	NNS
cord-104162-fe51v2pt	124	17	in	in	IN
cord-104162-fe51v2pt	124	18	base	base	NN
cord-104162-fe51v2pt	124	19	composition	composition	NN
cord-104162-fe51v2pt	124	20	;	;	:
cord-104162-fe51v2pt	124	21	GC%	GC%	NNP
cord-104162-fe51v2pt	124	22	)	)	-RRB-
cord-104162-fe51v2pt	124	23	can	can	MD
cord-104162-fe51v2pt	124	24	serve	serve	VB
cord-104162-fe51v2pt	124	25	to	to	TO
cord-104162-fe51v2pt	124	26	initiate	initiate	VB
cord-104162-fe51v2pt	124	27	divergence	divergence	NN
cord-104162-fe51v2pt	124	28	into	into	IN
cord-104162-fe51v2pt	124	29	new	new	JJ
cord-104162-fe51v2pt	124	30	species	specie	NNS
cord-104162-fe51v2pt	124	31	.	.	.
cord-104162-fe51v2pt	125	1	By	by	IN
cord-104162-fe51v2pt	125	2	preventing	prevent	VBG
cord-104162-fe51v2pt	125	3	that	that	DT
cord-104162-fe51v2pt	125	4	accumulation	accumulation	NN
cord-104162-fe51v2pt	125	5	,	,	,
cord-104162-fe51v2pt	125	6	potentially	potentially	RB
cord-104162-fe51v2pt	125	7	diverging	diverge	VBG
cord-104162-fe51v2pt	125	8	organisms	organism	NNS
cord-104162-fe51v2pt	125	9	can	can	MD
cord-104162-fe51v2pt	125	10	stay	stay	VB
cord-104162-fe51v2pt	125	11	within	within	IN
cord-104162-fe51v2pt	125	12	the	the	DT
cord-104162-fe51v2pt	125	13	confines	confine	NNS
cord-104162-fe51v2pt	125	14	of	of	IN
cord-104162-fe51v2pt	125	15	their	-PRON-	PRP$
cord-104162-fe51v2pt	125	16	species	specie	NNS
cord-104162-fe51v2pt	125	17	[	[	-LRB-
cord-104162-fe51v2pt	125	18	19	19	CD
cord-104162-fe51v2pt	125	19	]	]	-RRB-
cord-104162-fe51v2pt	125	20	[	[	-LRB-
cord-104162-fe51v2pt	125	21	20	20	CD
cord-104162-fe51v2pt	125	22	]	]	-RRB-
cord-104162-fe51v2pt	125	23	[	[	-LRB-
cord-104162-fe51v2pt	125	24	21	21	CD
cord-104162-fe51v2pt	125	25	]	]	-RRB-
cord-104162-fe51v2pt	125	26	.	.	.
cord-104162-fe51v2pt	126	1	The	the	DT
cord-104162-fe51v2pt	126	2	presence	presence	NN
cord-104162-fe51v2pt	126	3	or	or	CC
cord-104162-fe51v2pt	126	4	absence	absence	NN
cord-104162-fe51v2pt	126	5	of	of	IN
cord-104162-fe51v2pt	126	6	synonymous	synonymous	JJ
cord-104162-fe51v2pt	126	7	mutations	mutation	NNS
cord-104162-fe51v2pt	126	8	[	[	-LRB-
cord-104162-fe51v2pt	126	9	16	16	CD
cord-104162-fe51v2pt	126	10	,	,	,
cord-104162-fe51v2pt	126	11	40	40	CD
cord-104162-fe51v2pt	126	12	]	]	-RRB-
cord-104162-fe51v2pt	126	13	,	,	,
cord-104162-fe51v2pt	126	14	which	which	WDT
cord-104162-fe51v2pt	126	15	affect	affect	VBP
cord-104162-fe51v2pt	126	16	structure	structure	NN
cord-104162-fe51v2pt	126	17	rather	rather	RB
cord-104162-fe51v2pt	126	18	than	than	IN
cord-104162-fe51v2pt	126	19	amino	amino	NN
cord-104162-fe51v2pt	126	20	acid	acid	NN
cord-104162-fe51v2pt	126	21	composition	composition	NN
cord-104162-fe51v2pt	126	22	,	,	,
cord-104162-fe51v2pt	126	23	can	can	MD
cord-104162-fe51v2pt	126	24	have	have	VB
cord-104162-fe51v2pt	126	25	an	an	DT
cord-104162-fe51v2pt	126	26	important	important	JJ
cord-104162-fe51v2pt	126	27	role	role	NN
cord-104162-fe51v2pt	126	28	in	in	IN
cord-104162-fe51v2pt	126	29	this	this	DT
cord-104162-fe51v2pt	126	30	process	process	NN
cord-104162-fe51v2pt	126	31	.	.	.
cord-104162-fe51v2pt	127	1	The	the	DT
cord-104162-fe51v2pt	127	2	primary	primary	JJ
cord-104162-fe51v2pt	127	3	role	role	NN
cord-104162-fe51v2pt	127	4	of	of	IN
cord-104162-fe51v2pt	127	5	constancy	constancy	NN
cord-104162-fe51v2pt	127	6	in	in	IN
cord-104162-fe51v2pt	127	7	the	the	DT
cord-104162-fe51v2pt	127	8	base	base	NN
cord-104162-fe51v2pt	127	9	composition	composition	NN
cord-104162-fe51v2pt	127	10	-	-	HYPH
cord-104162-fe51v2pt	127	11	related	relate	VBN
cord-104162-fe51v2pt	127	12	character	character	NN
cord-104162-fe51v2pt	127	13	is	be	VBZ
cord-104162-fe51v2pt	127	14	to	to	TO
cord-104162-fe51v2pt	127	15	prevent	prevent	VB
cord-104162-fe51v2pt	127	16	recombination	recombination	NN
cord-104162-fe51v2pt	127	17	with	with	IN
cord-104162-fe51v2pt	127	18	allied	ally	VBN
cord-104162-fe51v2pt	127	19	species	specie	NNS
cord-104162-fe51v2pt	127	20	(	(	-LRB-
cord-104162-fe51v2pt	127	21	interspecies	interspecie	NNS
cord-104162-fe51v2pt	127	22	recombination	recombination	NN
cord-104162-fe51v2pt	127	23	)	)	-RRB-
cord-104162-fe51v2pt	127	24	while	while	IN
cord-104162-fe51v2pt	127	25	facilitating	facilitate	VBG
cord-104162-fe51v2pt	127	26	the	the	DT
cord-104162-fe51v2pt	127	27	intraspecies	intraspecie	NNS
cord-104162-fe51v2pt	127	28	recombination	recombination	NN
cord-104162-fe51v2pt	127	29	that	that	WDT
cord-104162-fe51v2pt	127	30	can	can	MD
cord-104162-fe51v2pt	127	31	correct	correct	VB
cord-104162-fe51v2pt	127	32	mutations	mutation	NNS
cord-104162-fe51v2pt	127	33	,	,	,
cord-104162-fe51v2pt	127	34	so	so	IN
cord-104162-fe51v2pt	127	35	retaining	retain	VBG
cord-104162-fe51v2pt	127	36	species	species	NN
cord-104162-fe51v2pt	127	37	individuality	individuality	NN
cord-104162-fe51v2pt	127	38	[	[	-LRB-
cord-104162-fe51v2pt	127	39	3	3	CD
cord-104162-fe51v2pt	127	40	,	,	,
cord-104162-fe51v2pt	127	41	7	7	CD
cord-104162-fe51v2pt	127	42	]	]	-RRB-
cord-104162-fe51v2pt	127	43	.	.	.
cord-104162-fe51v2pt	128	1	Such	such	JJ
cord-104162-fe51v2pt	128	2	recombination	recombination	NN
cord-104162-fe51v2pt	128	3	is	be	VBZ
cord-104162-fe51v2pt	128	4	initiated	initiate	VBN
cord-104162-fe51v2pt	128	5	by	by	IN
cord-104162-fe51v2pt	128	6	"	"	``
cord-104162-fe51v2pt	128	7	kissing	kiss	VBG
cord-104162-fe51v2pt	128	8	"	"	''
cord-104162-fe51v2pt	128	9	interactions	interaction	NNS
cord-104162-fe51v2pt	128	10	between	between	IN
cord-104162-fe51v2pt	128	11	complementary	complementary	JJ
cord-104162-fe51v2pt	128	12	unpaired	unpaired	JJ
cord-104162-fe51v2pt	128	13	bases	basis	NNS
cord-104162-fe51v2pt	128	14	at	at	IN
cord-104162-fe51v2pt	128	15	the	the	DT
cord-104162-fe51v2pt	128	16	tips	tip	NNS
cord-104162-fe51v2pt	128	17	of	of	IN
cord-104162-fe51v2pt	128	18	stem	stem	NN
cord-104162-fe51v2pt	128	19	-	-	HYPH
cord-104162-fe51v2pt	128	20	loop	loop	NN
cord-104162-fe51v2pt	128	21	structures	structure	NNS
cord-104162-fe51v2pt	128	22	[	[	-LRB-
cord-104162-fe51v2pt	128	23	19	19	CD
cord-104162-fe51v2pt	128	24	]	]	-RRB-
cord-104162-fe51v2pt	128	25	.	.	.
cord-104162-fe51v2pt	129	1	Thus	thus	RB
cord-104162-fe51v2pt	129	2	,	,	,
cord-104162-fe51v2pt	129	3	we	-PRON-	PRP
cord-104162-fe51v2pt	129	4	are	be	VBP
cord-104162-fe51v2pt	129	5	here	here	RB
cord-104162-fe51v2pt	129	6	concerned	concern	VBN
cord-104162-fe51v2pt	129	7	with	with	IN
cord-104162-fe51v2pt	129	8	localized	localized	JJ
cord-104162-fe51v2pt	129	9	intraspecies	intraspecie	NNS
cord-104162-fe51v2pt	129	10	mutations	mutation	NNS
cord-104162-fe51v2pt	129	11	that	that	WDT
cord-104162-fe51v2pt	129	12	affect	affect	VBP
cord-104162-fe51v2pt	129	13	fitness	fitness	NN
cord-104162-fe51v2pt	129	14	,	,	,
cord-104162-fe51v2pt	129	15	so	so	RB
cord-104162-fe51v2pt	129	16	making	make	VBG
cord-104162-fe51v2pt	129	17	members	member	NNS
cord-104162-fe51v2pt	129	18	of	of	IN
cord-104162-fe51v2pt	129	19	a	a	DT
cord-104162-fe51v2pt	129	20	species	species	NN
cord-104162-fe51v2pt	129	21	carrying	carry	VBG
cord-104162-fe51v2pt	129	22	those	those	DT
cord-104162-fe51v2pt	129	23	mutations	mutation	NNS
cord-104162-fe51v2pt	129	24	liable	liable	JJ
cord-104162-fe51v2pt	129	25	to	to	IN
cord-104162-fe51v2pt	129	26	natural	natural	JJ
cord-104162-fe51v2pt	129	27	selection	selection	NN
cord-104162-fe51v2pt	129	28	.	.	.
cord-104162-fe51v2pt	130	1	The	the	DT
cord-104162-fe51v2pt	130	2	mutations	mutation	NNS
cord-104162-fe51v2pt	130	3	1	1	CD
cord-104162-fe51v2pt	130	4	5	5	CD
cord-104162-fe51v2pt	130	5	facilitate	facilitate	VBP
cord-104162-fe51v2pt	130	6	within	within	IN
cord-104162-fe51v2pt	130	7	-	-	HYPH
cord-104162-fe51v2pt	130	8	species	species	NN
cord-104162-fe51v2pt	130	9	evolution	evolution	NN
cord-104162-fe51v2pt	130	10	rather	rather	RB
cord-104162-fe51v2pt	130	11	than	than	IN
cord-104162-fe51v2pt	130	12	divergence	divergence	NN
cord-104162-fe51v2pt	130	13	into	into	IN
cord-104162-fe51v2pt	130	14	new	new	JJ
cord-104162-fe51v2pt	130	15	species	specie	NNS
cord-104162-fe51v2pt	130	16	.	.	.
cord-104162-fe51v2pt	131	1	And	and	CC
cord-104162-fe51v2pt	131	2	when	when	WRB
cord-104162-fe51v2pt	131	3	that	that	DT
cord-104162-fe51v2pt	131	4	evolution	evolution	NN
cord-104162-fe51v2pt	131	5	has	have	VBZ
cord-104162-fe51v2pt	131	6	run	run	VBN
cord-104162-fe51v2pt	131	7	its	-PRON-	PRP$
cord-104162-fe51v2pt	131	8	course	course	NN
cord-104162-fe51v2pt	131	9	,	,	,
cord-104162-fe51v2pt	131	10	some	some	DT
cord-104162-fe51v2pt	131	11	of	of	IN
cord-104162-fe51v2pt	131	12	the	the	DT
cord-104162-fe51v2pt	131	13	polymorphic	polymorphic	JJ
cord-104162-fe51v2pt	131	14	bases	basis	NNS
cord-104162-fe51v2pt	131	15	will	will	MD
cord-104162-fe51v2pt	131	16	have	have	VB
cord-104162-fe51v2pt	131	17	become	become	VBN
cord-104162-fe51v2pt	131	18	less	less	RBR
cord-104162-fe51v2pt	131	19	mutable	mutable	JJ
cord-104162-fe51v2pt	131	20	,	,	,
cord-104162-fe51v2pt	131	21	so	so	RB
cord-104162-fe51v2pt	131	22	will	will	MD
cord-104162-fe51v2pt	131	23	be	be	VB
cord-104162-fe51v2pt	131	24	deemed	deem	VBN
cord-104162-fe51v2pt	131	25	"	"	``
cord-104162-fe51v2pt	131	26	conserved	conserve	VBN
cord-104162-fe51v2pt	131	27	.	.	.
cord-104162-fe51v2pt	131	28	"	"	''
cord-104162-fe51v2pt	132	1	Indeed	indeed	RB
cord-104162-fe51v2pt	132	2	,	,	,
cord-104162-fe51v2pt	132	3	mutations	mutation	NNS
cord-104162-fe51v2pt	132	4	of	of	IN
cord-104162-fe51v2pt	132	5	ORF	ORF	NNP
cord-104162-fe51v2pt	132	6	NSP3	NSP3	NNP
cord-104162-fe51v2pt	132	7	are	be	VBP
cord-104162-fe51v2pt	132	8	high	high	JJ
cord-104162-fe51v2pt	132	9	when	when	WRB
cord-104162-fe51v2pt	132	10	the	the	DT
cord-104162-fe51v2pt	132	11	sequences	sequence	NNS
cord-104162-fe51v2pt	132	12	of	of	IN
cord-104162-fe51v2pt	132	13	different	different	JJ
cord-104162-fe51v2pt	132	14	coronavirus	coronavirus	NN
cord-104162-fe51v2pt	132	15	species	specie	NNS
cord-104162-fe51v2pt	132	16	are	be	VBP
cord-104162-fe51v2pt	132	17	compared	compare	VBN
cord-104162-fe51v2pt	132	18	[	[	-LRB-
cord-104162-fe51v2pt	132	19	41	41	CD
cord-104162-fe51v2pt	132	20	]	]	-RRB-
cord-104162-fe51v2pt	132	21	,	,	,
cord-104162-fe51v2pt	132	22	yet	yet	CC
cord-104162-fe51v2pt	132	23	when	when	WRB
cord-104162-fe51v2pt	132	24	,	,	,
cord-104162-fe51v2pt	132	25	from	from	IN
cord-104162-fe51v2pt	132	26	intraspecies	intraspecie	NNS
cord-104162-fe51v2pt	132	27	comparisons	comparison	NNS
cord-104162-fe51v2pt	132	28	,	,	,
cord-104162-fe51v2pt	132	29	mutations	mutation	NNS
cord-104162-fe51v2pt	132	30	(	(	-LRB-
cord-104162-fe51v2pt	132	31	in	in	IN
cord-104162-fe51v2pt	132	32	the	the	DT
cord-104162-fe51v2pt	132	33	form	form	NN
cord-104162-fe51v2pt	132	34	of	of	IN
cord-104162-fe51v2pt	132	35	base	base	NN
cord-104162-fe51v2pt	132	36	substitutions	substitution	NNS
cord-104162-fe51v2pt	132	37	)	)	-RRB-
cord-104162-fe51v2pt	132	38	are	be	VBP
cord-104162-fe51v2pt	132	39	scored	score	VBN
cord-104162-fe51v2pt	132	40	,	,	,
cord-104162-fe51v2pt	132	41	they	-PRON-	PRP
cord-104162-fe51v2pt	132	42	are	be	VBP
cord-104162-fe51v2pt	132	43	very	very	RB
cord-104162-fe51v2pt	132	44	low	low	JJ
cord-104162-fe51v2pt	132	45	(	(	-LRB-
cord-104162-fe51v2pt	132	46	Figs	fig	NNS
cord-104162-fe51v2pt	132	47	.	.	.
cord-104162-fe51v2pt	133	1	3	3	CD
cord-104162-fe51v2pt	133	2	,	,	,
cord-104162-fe51v2pt	133	3	4	4	CD
cord-104162-fe51v2pt	133	4	)	)	-RRB-
cord-104162-fe51v2pt	133	5	.	.	.
cord-104162-fe51v2pt	134	1	Our	-PRON-	PRP$
cord-104162-fe51v2pt	134	2	technology	technology	NN
cord-104162-fe51v2pt	134	3	(	(	-LRB-
cord-104162-fe51v2pt	134	4	see	see	VB
cord-104162-fe51v2pt	134	5	Materials	material	NNS
cord-104162-fe51v2pt	134	6	and	and	CC
cord-104162-fe51v2pt	134	7	Methods	Methods	NNPS
cord-104162-fe51v2pt	134	8	)	)	-RRB-
cord-104162-fe51v2pt	134	9	removes	remove	VBZ
cord-104162-fe51v2pt	134	10	the	the	DT
cord-104162-fe51v2pt	134	11	base	base	NN
cord-104162-fe51v2pt	134	12	composition	composition	NN
cord-104162-fe51v2pt	134	13	-	-	HYPH
cord-104162-fe51v2pt	134	14	dependent	dependent	JJ
cord-104162-fe51v2pt	134	15	component	component	NN
cord-104162-fe51v2pt	134	16	of	of	IN
cord-104162-fe51v2pt	134	17	mutational	mutational	JJ
cord-104162-fe51v2pt	134	18	changes	change	NNS
cord-104162-fe51v2pt	134	19	(	(	-LRB-
cord-104162-fe51v2pt	134	20	that	that	DT
cord-104162-fe51v2pt	134	21	relates	relate	VBZ
cord-104162-fe51v2pt	134	22	more	more	JJR
cord-104162-fe51v2pt	134	23	to	to	IN
cord-104162-fe51v2pt	134	24	interspecies	interspecie	NNS
cord-104162-fe51v2pt	134	25	evolution	evolution	NN
cord-104162-fe51v2pt	134	26	)	)	-RRB-
cord-104162-fe51v2pt	134	27	and	and	CC
cord-104162-fe51v2pt	134	28	focuses	focus	VBZ
cord-104162-fe51v2pt	134	29	on	on	IN
cord-104162-fe51v2pt	134	30	the	the	DT
cord-104162-fe51v2pt	134	31	base	base	JJ
cord-104162-fe51v2pt	134	32	orderdependent	orderdependent	NN
cord-104162-fe51v2pt	134	33	component	component	NN
cord-104162-fe51v2pt	134	34	(	(	-LRB-
cord-104162-fe51v2pt	134	35	that	that	DT
cord-104162-fe51v2pt	134	36	relates	relate	VBZ
cord-104162-fe51v2pt	134	37	more	more	JJR
cord-104162-fe51v2pt	134	38	to	to	IN
cord-104162-fe51v2pt	134	39	intraspecies	intraspecie	NNS
cord-104162-fe51v2pt	134	40	evolution	evolution	NN
cord-104162-fe51v2pt	134	41	)	)	-RRB-
cord-104162-fe51v2pt	134	42	.	.	.
cord-104162-fe51v2pt	135	1	It	-PRON-	PRP
cord-104162-fe51v2pt	135	2	best	best	RB
cord-104162-fe51v2pt	135	3	reflects	reflect	VBZ
cord-104162-fe51v2pt	135	4	localized	localize	VBN
cord-104162-fe51v2pt	135	5	functions	function	NNS
cord-104162-fe51v2pt	135	6	,	,	,
cord-104162-fe51v2pt	135	7	be	be	VB
cord-104162-fe51v2pt	135	8	they	-PRON-	PRP
cord-104162-fe51v2pt	135	9	encoding	encode	VBG
cord-104162-fe51v2pt	135	10	protein	protein	NN
cord-104162-fe51v2pt	135	11	or	or	CC
cord-104162-fe51v2pt	135	12	determining	determine	VBG
cord-104162-fe51v2pt	135	13	the	the	DT
cord-104162-fe51v2pt	135	14	potentiality	potentiality	NN
cord-104162-fe51v2pt	135	15	for	for	IN
cord-104162-fe51v2pt	135	16	folding	fold	VBG
cord-104162-fe51v2pt	135	17	into	into	IN
cord-104162-fe51v2pt	135	18	higher	high	JJR
cord-104162-fe51v2pt	135	19	order	order	NN
cord-104162-fe51v2pt	135	20	structure	structure	NN
cord-104162-fe51v2pt	135	21	,	,	,
cord-104162-fe51v2pt	135	22	of	of	IN
cord-104162-fe51v2pt	135	23	linear	linear	JJ
cord-104162-fe51v2pt	135	24	,	,	,
cord-104162-fe51v2pt	135	25	single	single	JJ
cord-104162-fe51v2pt	135	26	-	-	HYPH
cord-104162-fe51v2pt	135	27	stranded	stranded	JJ
cord-104162-fe51v2pt	135	28	,	,	,
cord-104162-fe51v2pt	135	29	nucleic	nucleic	JJ
cord-104162-fe51v2pt	135	30	acid	acid	NN
cord-104162-fe51v2pt	135	31	sequences	sequence	NNS
cord-104162-fe51v2pt	135	32	.	.	.
cord-104162-fe51v2pt	136	1	Is	be	VBZ
cord-104162-fe51v2pt	136	2	conservation	conservation	NN
cord-104162-fe51v2pt	136	3	necessarily	necessarily	RB
cord-104162-fe51v2pt	136	4	a	a	DT
cord-104162-fe51v2pt	136	5	good	good	JJ
cord-104162-fe51v2pt	136	6	indicator	indicator	NN
cord-104162-fe51v2pt	136	7	of	of	IN
cord-104162-fe51v2pt	136	8	likely	likely	JJ
cord-104162-fe51v2pt	136	9	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	136	10	success	success	NN
cord-104162-fe51v2pt	136	11	?	?	.
cord-104162-fe51v2pt	137	1	We	-PRON-	PRP
cord-104162-fe51v2pt	137	2	sought	seek	VBD
cord-104162-fe51v2pt	137	3	regions	region	NNS
cord-104162-fe51v2pt	137	4	that	that	WDT
cord-104162-fe51v2pt	137	5	were	be	VBD
cord-104162-fe51v2pt	137	6	both	both	DT
cord-104162-fe51v2pt	137	7	high	high	JJ
cord-104162-fe51v2pt	137	8	in	in	IN
cord-104162-fe51v2pt	137	9	stem	stem	NN
cord-104162-fe51v2pt	137	10	-	-	HYPH
cord-104162-fe51v2pt	137	11	loop	loop	NN
cord-104162-fe51v2pt	137	12	potential	potential	NN
cord-104162-fe51v2pt	137	13	and	and	CC
cord-104162-fe51v2pt	137	14	bereft	bereft	JJ
cord-104162-fe51v2pt	137	15	of	of	IN
cord-104162-fe51v2pt	137	16	mutations	mutation	NNS
cord-104162-fe51v2pt	137	17	,	,	,
cord-104162-fe51v2pt	137	18	following	follow	VBG
cord-104162-fe51v2pt	137	19	the	the	DT
cord-104162-fe51v2pt	137	20	premise	premise	NN
cord-104162-fe51v2pt	137	21	that	that	IN
cord-104162-fe51v2pt	137	22	conserved	conserve	VBN
cord-104162-fe51v2pt	137	23	functions	function	NNS
cord-104162-fe51v2pt	137	24	would	would	MD
cord-104162-fe51v2pt	137	25	be	be	VB
cord-104162-fe51v2pt	137	26	best	well	RBS
cord-104162-fe51v2pt	137	27	targeted	target	VBN
cord-104162-fe51v2pt	137	28	therapeutically	therapeutically	RB
cord-104162-fe51v2pt	137	29	,	,	,
cord-104162-fe51v2pt	137	30	assuming	assume	VBG
cord-104162-fe51v2pt	137	31	the	the	DT
cord-104162-fe51v2pt	137	32	availability	availability	NN
cord-104162-fe51v2pt	137	33	of	of	IN
cord-104162-fe51v2pt	137	34	pathogen	pathogen	NN
cord-104162-fe51v2pt	137	35	-	-	HYPH
cord-104162-fe51v2pt	137	36	specific	specific	JJ
cord-104162-fe51v2pt	137	37	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	137	38	agents	agent	NNS
cord-104162-fe51v2pt	137	39	that	that	WDT
cord-104162-fe51v2pt	137	40	would	would	MD
cord-104162-fe51v2pt	137	41	not	not	RB
cord-104162-fe51v2pt	137	42	cross	cross	VB
cord-104162-fe51v2pt	137	43	-	-	JJ
cord-104162-fe51v2pt	137	44	react	react	VB
cord-104162-fe51v2pt	137	45	with	with	IN
cord-104162-fe51v2pt	137	46	hosts	host	NNS
cord-104162-fe51v2pt	137	47	.	.	.
cord-104162-fe51v2pt	138	1	Interference	interference	NN
cord-104162-fe51v2pt	138	2	with	with	IN
cord-104162-fe51v2pt	138	3	structural	structural	JJ
cord-104162-fe51v2pt	138	4	nucleic	nucleic	JJ
cord-104162-fe51v2pt	138	5	acid	acid	NN
cord-104162-fe51v2pt	138	6	level	level	NN
cord-104162-fe51v2pt	138	7	functions	function	NNS
cord-104162-fe51v2pt	138	8	would	would	MD
cord-104162-fe51v2pt	138	9	seem	seem	VB
cord-104162-fe51v2pt	138	10	less	less	RBR
cord-104162-fe51v2pt	138	11	likely	likely	JJ
cord-104162-fe51v2pt	138	12	to	to	TO
cord-104162-fe51v2pt	138	13	produce	produce	VB
cord-104162-fe51v2pt	138	14	unforeseen	unforeseen	JJ
cord-104162-fe51v2pt	138	15	host	host	NN
cord-104162-fe51v2pt	138	16	sideeffects	sideeffect	NNS
cord-104162-fe51v2pt	138	17	than	than	IN
cord-104162-fe51v2pt	138	18	with	with	IN
cord-104162-fe51v2pt	138	19	protein	protein	NN
cord-104162-fe51v2pt	138	20	-	-	HYPH
cord-104162-fe51v2pt	138	21	level	level	NN
cord-104162-fe51v2pt	138	22	functions	function	NNS
cord-104162-fe51v2pt	138	23	.	.	.
cord-104162-fe51v2pt	139	1	Yet	yet	CC
cord-104162-fe51v2pt	139	2	,	,	,
cord-104162-fe51v2pt	139	3	that	that	DT
cord-104162-fe51v2pt	139	4	possibility	possibility	NN
cord-104162-fe51v2pt	139	5	remains	remain	VBZ
cord-104162-fe51v2pt	139	6	.	.	.
cord-104162-fe51v2pt	140	1	Indeed	indeed	RB
cord-104162-fe51v2pt	140	2	,	,	,
cord-104162-fe51v2pt	140	3	a	a	DT
cord-104162-fe51v2pt	140	4	conserved	conserved	JJ
cord-104162-fe51v2pt	140	5	function	function	NN
cord-104162-fe51v2pt	140	6	in	in	IN
cord-104162-fe51v2pt	140	7	a	a	DT
cord-104162-fe51v2pt	140	8	pathogen	pathogen	NN
cord-104162-fe51v2pt	140	9	could	could	MD
cord-104162-fe51v2pt	140	10	owe	owe	VB
cord-104162-fe51v2pt	140	11	that	that	DT
cord-104162-fe51v2pt	140	12	conservation	conservation	NN
cord-104162-fe51v2pt	140	13	to	to	IN
cord-104162-fe51v2pt	140	14	the	the	DT
cord-104162-fe51v2pt	140	15	pathogen	pathogen	NN
cord-104162-fe51v2pt	140	16	strategy	strategy	NN
cord-104162-fe51v2pt	140	17	of	of	IN
cord-104162-fe51v2pt	140	18	,	,	,
cord-104162-fe51v2pt	140	19	whenever	whenever	WRB
cord-104162-fe51v2pt	140	20	possible	possible	JJ
cord-104162-fe51v2pt	140	21	,	,	,
cord-104162-fe51v2pt	140	22	mutating	mutate	VBG
cord-104162-fe51v2pt	140	23	to	to	TO
cord-104162-fe51v2pt	140	24	resemble	resemble	VB
cord-104162-fe51v2pt	140	25	its	-PRON-	PRP$
cord-104162-fe51v2pt	140	26	host	host	NN
cord-104162-fe51v2pt	140	27	.	.	.
cord-104162-fe51v2pt	141	1	This	this	DT
cord-104162-fe51v2pt	141	2	would	would	MD
cord-104162-fe51v2pt	141	3	make	make	VB
cord-104162-fe51v2pt	141	4	it	-PRON-	PRP
cord-104162-fe51v2pt	141	5	less	less	RBR
cord-104162-fe51v2pt	141	6	vulnerable	vulnerable	JJ
cord-104162-fe51v2pt	141	7	to	to	TO
cord-104162-fe51v2pt	141	8	host	host	VB
cord-104162-fe51v2pt	141	9	immune	immune	JJ
cord-104162-fe51v2pt	141	10	defenses	defense	NNS
cord-104162-fe51v2pt	141	11	.	.	.
cord-104162-fe51v2pt	142	1	To	to	TO
cord-104162-fe51v2pt	142	2	prevent	prevent	VB
cord-104162-fe51v2pt	142	3	autoimmunity	autoimmunity	NN
cord-104162-fe51v2pt	142	4	,	,	,
cord-104162-fe51v2pt	142	5	the	the	DT
cord-104162-fe51v2pt	142	6	generation	generation	NN
cord-104162-fe51v2pt	142	7	of	of	IN
cord-104162-fe51v2pt	142	8	immune	immune	JJ
cord-104162-fe51v2pt	142	9	cell	cell	NN
cord-104162-fe51v2pt	142	10	repertoires	repertoire	NNS
cord-104162-fe51v2pt	142	11	involves	involve	VBZ
cord-104162-fe51v2pt	142	12	the	the	DT
cord-104162-fe51v2pt	142	13	negative	negative	JJ
cord-104162-fe51v2pt	142	14	selection	selection	NN
cord-104162-fe51v2pt	142	15	of	of	IN
cord-104162-fe51v2pt	142	16	self	self	NN
cord-104162-fe51v2pt	142	17	-	-	HYPH
cord-104162-fe51v2pt	142	18	reacting	react	VBG
cord-104162-fe51v2pt	142	19	cells	cell	NNS
cord-104162-fe51v2pt	142	20	so	so	IN
cord-104162-fe51v2pt	142	21	creating	create	VBG
cord-104162-fe51v2pt	142	22	"	"	``
cord-104162-fe51v2pt	142	23	holes	hole	NNS
cord-104162-fe51v2pt	142	24	"	"	''
cord-104162-fe51v2pt	142	25	in	in	IN
cord-104162-fe51v2pt	142	26	the	the	DT
cord-104162-fe51v2pt	142	27	repertoire	repertoire	NN
cord-104162-fe51v2pt	142	28	that	that	IN
cord-104162-fe51v2pt	142	29	pathogens	pathogen	NNS
cord-104162-fe51v2pt	142	30	can	can	MD
cord-104162-fe51v2pt	142	31	exploit	exploit	VB
cord-104162-fe51v2pt	142	32	by	by	IN
cord-104162-fe51v2pt	142	33	progressive	progressive	JJ
cord-104162-fe51v2pt	142	34	mutation	mutation	NN
cord-104162-fe51v2pt	142	35	towards	towards	IN
cord-104162-fe51v2pt	142	36	host	host	NN
cord-104162-fe51v2pt	142	37	-	-	HYPH
cord-104162-fe51v2pt	142	38	self	self	NN
cord-104162-fe51v2pt	142	39	,	,	,
cord-104162-fe51v2pt	142	40	testing	test	VBG
cord-104162-fe51v2pt	142	41	mutational	mutational	JJ
cord-104162-fe51v2pt	142	42	effectiveness	effectiveness	NN
cord-104162-fe51v2pt	142	43	a	a	DT
cord-104162-fe51v2pt	142	44	step	step	NN
cord-104162-fe51v2pt	142	45	at	at	IN
cord-104162-fe51v2pt	142	46	a	a	DT
cord-104162-fe51v2pt	142	47	time	time	NN
cord-104162-fe51v2pt	142	48	.	.	.
cord-104162-fe51v2pt	143	1	This	this	DT
cord-104162-fe51v2pt	143	2	would	would	MD
cord-104162-fe51v2pt	143	3	make	make	VB
cord-104162-fe51v2pt	143	4	it	-PRON-	PRP
cord-104162-fe51v2pt	143	5	advantageous	advantageous	JJ
cord-104162-fe51v2pt	143	6	for	for	IN
cord-104162-fe51v2pt	143	7	the	the	DT
cord-104162-fe51v2pt	143	8	host	host	NN
cord-104162-fe51v2pt	143	9	,	,	,
cord-104162-fe51v2pt	143	10	during	during	IN
cord-104162-fe51v2pt	143	11	the	the	DT
cord-104162-fe51v2pt	143	12	process	process	NN
cord-104162-fe51v2pt	143	13	of	of	IN
cord-104162-fe51v2pt	143	14	repertoire	repertoire	NN
cord-104162-fe51v2pt	143	15	generation	generation	NN
cord-104162-fe51v2pt	143	16	,	,	,
cord-104162-fe51v2pt	143	17	not	not	RB
cord-104162-fe51v2pt	143	18	only	only	RB
cord-104162-fe51v2pt	143	19	to	to	TO
cord-104162-fe51v2pt	143	20	negatively	negatively	RB
cord-104162-fe51v2pt	143	21	select	select	VB
cord-104162-fe51v2pt	143	22	immune	immune	JJ
cord-104162-fe51v2pt	143	23	cells	cell	NNS
cord-104162-fe51v2pt	143	24	of	of	IN
cord-104162-fe51v2pt	143	25	specificity	specificity	NN
cord-104162-fe51v2pt	143	26	towards	towards	IN
cord-104162-fe51v2pt	143	27	"	"	``
cord-104162-fe51v2pt	143	28	self	self	NN
cord-104162-fe51v2pt	143	29	,	,	,
cord-104162-fe51v2pt	143	30	"	"	''
cord-104162-fe51v2pt	143	31	but	but	CC
cord-104162-fe51v2pt	143	32	also	also	RB
cord-104162-fe51v2pt	143	33	to	to	TO
cord-104162-fe51v2pt	143	34	positively	positively	RB
cord-104162-fe51v2pt	143	35	select	select	VB
cord-104162-fe51v2pt	143	36	immune	immune	JJ
cord-104162-fe51v2pt	143	37	cells	cell	NNS
cord-104162-fe51v2pt	143	38	of	of	IN
cord-104162-fe51v2pt	143	39	specificity	specificity	NN
cord-104162-fe51v2pt	143	40	towards	towards	IN
cord-104162-fe51v2pt	143	41	"	"	``
cord-104162-fe51v2pt	143	42	near	near	NN
cord-104162-fe51v2pt	143	43	-	-	HYPH
cord-104162-fe51v2pt	143	44	self	self	NN
cord-104162-fe51v2pt	143	45	.	.	.
cord-104162-fe51v2pt	143	46	"	"	''
cord-104162-fe51v2pt	144	1	A	a	DT
cord-104162-fe51v2pt	144	2	high	high	JJ
cord-104162-fe51v2pt	144	3	level	level	NN
cord-104162-fe51v2pt	144	4	of	of	IN
cord-104162-fe51v2pt	144	5	anti	anti	JJ
cord-104162-fe51v2pt	144	6	-	-	JJ
cord-104162-fe51v2pt	144	7	near	near	JJ
cord-104162-fe51v2pt	144	8	-	-	HYPH
cord-104162-fe51v2pt	144	9	self	self	NN
cord-104162-fe51v2pt	144	10	immune	immune	JJ
cord-104162-fe51v2pt	144	11	cell	cell	NN
cord-104162-fe51v2pt	144	12	clones	clone	NNS
cord-104162-fe51v2pt	144	13	would	would	MD
cord-104162-fe51v2pt	144	14	constitute	constitute	VB
cord-104162-fe51v2pt	144	15	a	a	DT
cord-104162-fe51v2pt	144	16	barrier	barrier	NN
cord-104162-fe51v2pt	144	17	limiting	limit	VBG
cord-104162-fe51v2pt	144	18	the	the	DT
cord-104162-fe51v2pt	144	19	extent	extent	NN
cord-104162-fe51v2pt	144	20	of	of	IN
cord-104162-fe51v2pt	144	21	pathogen	pathogen	NN
cord-104162-fe51v2pt	144	22	mutation	mutation	NN
cord-104162-fe51v2pt	144	23	towards	towards	IN
cord-104162-fe51v2pt	144	24	self	self	NN
cord-104162-fe51v2pt	144	25	.	.	.
cord-104162-fe51v2pt	145	1	The	the	DT
cord-104162-fe51v2pt	145	2	existence	existence	NN
cord-104162-fe51v2pt	145	3	of	of	IN
cord-104162-fe51v2pt	145	4	such	such	JJ
cord-104162-fe51v2pt	145	5	positive	positive	JJ
cord-104162-fe51v2pt	145	6	selection	selection	NN
cord-104162-fe51v2pt	145	7	is	be	VBZ
cord-104162-fe51v2pt	145	8	now	now	RB
cord-104162-fe51v2pt	145	9	generally	generally	RB
cord-104162-fe51v2pt	145	10	accepted	accept	VBN
cord-104162-fe51v2pt	145	11	,	,	,
cord-104162-fe51v2pt	145	12	with	with	IN
cord-104162-fe51v2pt	145	13	the	the	DT
cord-104162-fe51v2pt	145	14	implication	implication	NN
cord-104162-fe51v2pt	145	15	that	that	IN
cord-104162-fe51v2pt	145	16	some	some	DT
cord-104162-fe51v2pt	145	17	pathogen	pathogen	NN
cord-104162-fe51v2pt	145	18	functions	function	NNS
cord-104162-fe51v2pt	145	19	might	may	MD
cord-104162-fe51v2pt	145	20	have	have	VB
cord-104162-fe51v2pt	145	21	approached	approach	VBN
cord-104162-fe51v2pt	145	22	so	so	RB
cord-104162-fe51v2pt	145	23	close	close	JJ
cord-104162-fe51v2pt	145	24	to	to	TO
cord-104162-fe51v2pt	145	25	host	host	NN
cord-104162-fe51v2pt	145	26	-	-	HYPH
cord-104162-fe51v2pt	145	27	self	self	NN
cord-104162-fe51v2pt	145	28	that	that	WDT
cord-104162-fe51v2pt	145	29	targeting	target	VBG
cord-104162-fe51v2pt	145	30	them	-PRON-	PRP
cord-104162-fe51v2pt	145	31	therapeutically	therapeutically	RB
cord-104162-fe51v2pt	145	32	would	would	MD
cord-104162-fe51v2pt	145	33	result	result	VB
cord-104162-fe51v2pt	145	34	in	in	IN
cord-104162-fe51v2pt	145	35	cross	cross	NN
cord-104162-fe51v2pt	145	36	-	-	NN
cord-104162-fe51v2pt	145	37	reactivity	reactivity	JJ
cord-104162-fe51v2pt	145	38	[	[	-LRB-
cord-104162-fe51v2pt	145	39	42	42	CD
cord-104162-fe51v2pt	145	40	]	]	-RRB-
cord-104162-fe51v2pt	145	41	.	.	.
cord-104162-fe51v2pt	146	1	1	1	LS
cord-104162-fe51v2pt	146	2	6	6	CD
cord-104162-fe51v2pt	146	3	This	this	DT
cord-104162-fe51v2pt	146	4	unlikely	unlikely	JJ
cord-104162-fe51v2pt	146	5	caveat	caveat	NN
cord-104162-fe51v2pt	146	6	aside	aside	RB
cord-104162-fe51v2pt	146	7	,	,	,
cord-104162-fe51v2pt	146	8	we	-PRON-	PRP
cord-104162-fe51v2pt	146	9	deem	deem	VBP
cord-104162-fe51v2pt	146	10	conservation	conservation	NN
cord-104162-fe51v2pt	146	11	a	a	DT
cord-104162-fe51v2pt	146	12	reliable	reliable	JJ
cord-104162-fe51v2pt	146	13	indicator	indicator	NN
cord-104162-fe51v2pt	146	14	that	that	IN
cord-104162-fe51v2pt	146	15	a	a	DT
cord-104162-fe51v2pt	146	16	certain	certain	JJ
cord-104162-fe51v2pt	146	17	pathogen	pathogen	NN
cord-104162-fe51v2pt	146	18	function	function	NN
cord-104162-fe51v2pt	146	19	is	be	VBZ
cord-104162-fe51v2pt	146	20	likely	likely	JJ
cord-104162-fe51v2pt	146	21	to	to	TO
cord-104162-fe51v2pt	146	22	be	be	VB
cord-104162-fe51v2pt	146	23	a	a	DT
cord-104162-fe51v2pt	146	24	suitable	suitable	JJ
cord-104162-fe51v2pt	146	25	target	target	NN
cord-104162-fe51v2pt	146	26	for	for	IN
cord-104162-fe51v2pt	146	27	therapy	therapy	NN
cord-104162-fe51v2pt	146	28	.	.	.
cord-104162-fe51v2pt	147	1	Attacking	attack	VBG
cord-104162-fe51v2pt	147	2	a	a	DT
cord-104162-fe51v2pt	147	3	short	short	JJ
cord-104162-fe51v2pt	147	4	segment	segment	NN
cord-104162-fe51v2pt	147	5	of	of	IN
cord-104162-fe51v2pt	147	6	a	a	DT
cord-104162-fe51v2pt	147	7	pathogen	pathogen	NN
cord-104162-fe51v2pt	147	8	nucleic	nucleic	VBZ
cord-104162-fe51v2pt	147	9	acid	acid	NN
cord-104162-fe51v2pt	147	10	sequence	sequence	NN
cord-104162-fe51v2pt	147	11	is	be	VBZ
cord-104162-fe51v2pt	147	12	unlikely	unlikely	JJ
cord-104162-fe51v2pt	147	13	to	to	TO
cord-104162-fe51v2pt	147	14	ensnare	ensnare	VB
cord-104162-fe51v2pt	147	15	a	a	DT
cord-104162-fe51v2pt	147	16	similar	similar	JJ
cord-104162-fe51v2pt	147	17	segment	segment	NN
cord-104162-fe51v2pt	147	18	of	of	IN
cord-104162-fe51v2pt	147	19	its	-PRON-	PRP$
cord-104162-fe51v2pt	147	20	host	host	NN
cord-104162-fe51v2pt	147	21	's	's	POS
cord-104162-fe51v2pt	147	22	nucleic	nucleic	JJ
cord-104162-fe51v2pt	147	23	acid	acid	NN
cord-104162-fe51v2pt	147	24	.	.	.
cord-104162-fe51v2pt	148	1	In	in	IN
cord-104162-fe51v2pt	148	2	any	any	DT
cord-104162-fe51v2pt	148	3	case	case	NN
cord-104162-fe51v2pt	148	4	,	,	,
cord-104162-fe51v2pt	148	5	to	to	TO
cord-104162-fe51v2pt	148	6	militate	militate	VB
cord-104162-fe51v2pt	148	7	against	against	IN
cord-104162-fe51v2pt	148	8	this	this	DT
cord-104162-fe51v2pt	148	9	,	,	,
cord-104162-fe51v2pt	148	10	the	the	DT
cord-104162-fe51v2pt	148	11	pathogen	pathogen	NN
cord-104162-fe51v2pt	148	12	specificity	specificity	NN
cord-104162-fe51v2pt	148	13	of	of	IN
cord-104162-fe51v2pt	148	14	a	a	DT
cord-104162-fe51v2pt	148	15	potential	potential	JJ
cord-104162-fe51v2pt	148	16	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	148	17	agent	agent	NN
cord-104162-fe51v2pt	148	18	can	can	MD
cord-104162-fe51v2pt	148	19	be	be	VB
cord-104162-fe51v2pt	148	20	screened	screen	VBN
cord-104162-fe51v2pt	148	21	against	against	IN
cord-104162-fe51v2pt	148	22	the	the	DT
cord-104162-fe51v2pt	148	23	prototypic	prototypic	NNP
cord-104162-fe51v2pt	148	24	human	human	JJ
cord-104162-fe51v2pt	148	25	genomic	genomic	JJ
cord-104162-fe51v2pt	148	26	sequence	sequence	NN
cord-104162-fe51v2pt	148	27	(	(	-LRB-
cord-104162-fe51v2pt	148	28	assuming	assume	VBG
cord-104162-fe51v2pt	148	29	it	-PRON-	PRP
cord-104162-fe51v2pt	148	30	is	be	VBZ
cord-104162-fe51v2pt	148	31	unlikely	unlikely	JJ
cord-104162-fe51v2pt	148	32	that	that	IN
cord-104162-fe51v2pt	148	33	patient	patient	NN
cord-104162-fe51v2pt	148	34	genomes	genome	NNS
cord-104162-fe51v2pt	148	35	will	will	MD
cord-104162-fe51v2pt	148	36	significantly	significantly	RB
cord-104162-fe51v2pt	148	37	depart	depart	VB
cord-104162-fe51v2pt	148	38	from	from	IN
cord-104162-fe51v2pt	148	39	this	this	DT
cord-104162-fe51v2pt	148	40	)	)	-RRB-
cord-104162-fe51v2pt	148	41	.	.	.
cord-104162-fe51v2pt	149	1	While	while	IN
cord-104162-fe51v2pt	149	2	prospects	prospect	NNS
cord-104162-fe51v2pt	149	3	for	for	IN
cord-104162-fe51v2pt	149	4	the	the	DT
cord-104162-fe51v2pt	149	5	development	development	NN
cord-104162-fe51v2pt	149	6	of	of	IN
cord-104162-fe51v2pt	149	7	prophylactic	prophylactic	JJ
cord-104162-fe51v2pt	149	8	vaccines	vaccine	NNS
cord-104162-fe51v2pt	149	9	against	against	IN
cord-104162-fe51v2pt	149	10	infection	infection	NN
cord-104162-fe51v2pt	149	11	with	with	IN
cord-104162-fe51v2pt	149	12	SARS	SARS	NNP
cord-104162-fe51v2pt	149	13	-	-	HYPH
cord-104162-fe51v2pt	149	14	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	149	15	are	be	VBP
cord-104162-fe51v2pt	149	16	promising	promising	JJ
cord-104162-fe51v2pt	149	17	,	,	,
cord-104162-fe51v2pt	149	18	methods	method	NNS
cord-104162-fe51v2pt	149	19	to	to	TO
cord-104162-fe51v2pt	149	20	boost	boost	VB
cord-104162-fe51v2pt	149	21	post	post	NN
cord-104162-fe51v2pt	149	22	-	-	JJ
cord-104162-fe51v2pt	149	23	infection	infection	JJ
cord-104162-fe51v2pt	149	24	host	host	NN
cord-104162-fe51v2pt	149	25	immune	immune	JJ
cord-104162-fe51v2pt	149	26	defenses	defense	NNS
cord-104162-fe51v2pt	149	27	and	and	CC
cord-104162-fe51v2pt	149	28	to	to	TO
cord-104162-fe51v2pt	149	29	directly	directly	RB
cord-104162-fe51v2pt	149	30	target	target	VB
cord-104162-fe51v2pt	149	31	SARS	SARS	NNP
cord-104162-fe51v2pt	149	32	-	-	HYPH
cord-104162-fe51v2pt	149	33	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	149	34	are	be	VBP
cord-104162-fe51v2pt	149	35	urgently	urgently	RB
cord-104162-fe51v2pt	149	36	needed	need	VBN
cord-104162-fe51v2pt	149	37	.	.	.
cord-104162-fe51v2pt	150	1	These	these	DT
cord-104162-fe51v2pt	150	2	require	require	VBP
cord-104162-fe51v2pt	150	3	a	a	DT
cord-104162-fe51v2pt	150	4	better	well	JJR
cord-104162-fe51v2pt	150	5	understanding	understanding	NN
cord-104162-fe51v2pt	150	6	both	both	DT
cord-104162-fe51v2pt	150	7	of	of	IN
cord-104162-fe51v2pt	150	8	viral	viral	JJ
cord-104162-fe51v2pt	150	9	interactions	interaction	NNS
cord-104162-fe51v2pt	150	10	with	with	IN
cord-104162-fe51v2pt	150	11	host	host	NN
cord-104162-fe51v2pt	150	12	innate	innate	JJ
cord-104162-fe51v2pt	150	13	and	and	CC
cord-104162-fe51v2pt	150	14	acquired	acquire	VBD
cord-104162-fe51v2pt	150	15	immune	immune	JJ
cord-104162-fe51v2pt	150	16	systems	system	NNS
cord-104162-fe51v2pt	150	17	[	[	-LRB-
cord-104162-fe51v2pt	150	18	42	42	CD
cord-104162-fe51v2pt	150	19	]	]	-RRB-
cord-104162-fe51v2pt	150	20	,	,	,
cord-104162-fe51v2pt	150	21	and	and	CC
cord-104162-fe51v2pt	150	22	of	of	IN
cord-104162-fe51v2pt	150	23	viral	viral	JJ
cord-104162-fe51v2pt	150	24	vulnerabilities	vulnerability	NNS
cord-104162-fe51v2pt	150	25	.	.	.
cord-104162-fe51v2pt	151	1	The	the	DT
cord-104162-fe51v2pt	151	2	latter	latter	JJ
cord-104162-fe51v2pt	151	3	enquiry	enquiry	NN
cord-104162-fe51v2pt	151	4	proceeds	proceed	VBZ
cord-104162-fe51v2pt	151	5	in	in	IN
cord-104162-fe51v2pt	151	6	three	three	CD
cord-104162-fe51v2pt	151	7	steps	step	NNS
cord-104162-fe51v2pt	151	8	:	:	:
cord-104162-fe51v2pt	151	9	Find	find	VB
cord-104162-fe51v2pt	151	10	specific	specific	JJ
cord-104162-fe51v2pt	151	11	"	"	``
cord-104162-fe51v2pt	151	12	Achilles	Achilles	NNP
cord-104162-fe51v2pt	151	13	heels	heel	NNS
cord-104162-fe51v2pt	151	14	.	.	.
cord-104162-fe51v2pt	152	1	"	"	``
cord-104162-fe51v2pt	152	2	Design	design	NN
cord-104162-fe51v2pt	152	3	therapies	therapy	NNS
cord-104162-fe51v2pt	152	4	to	to	TO
cord-104162-fe51v2pt	152	5	exploit	exploit	VB
cord-104162-fe51v2pt	152	6	them	-PRON-	PRP
cord-104162-fe51v2pt	152	7	.	.	.
cord-104162-fe51v2pt	153	1	Prove	prove	VB
cord-104162-fe51v2pt	153	2	their	-PRON-	PRP$
cord-104162-fe51v2pt	153	3	clinical	clinical	JJ
cord-104162-fe51v2pt	153	4	effectiveness	effectiveness	NN
cord-104162-fe51v2pt	153	5	.	.	.
cord-104162-fe51v2pt	154	1	We	-PRON-	PRP
cord-104162-fe51v2pt	154	2	have	have	VBP
cord-104162-fe51v2pt	154	3	here	here	RB
cord-104162-fe51v2pt	154	4	been	be	VBN
cord-104162-fe51v2pt	154	5	concerned	concern	VBN
cord-104162-fe51v2pt	154	6	with	with	IN
cord-104162-fe51v2pt	154	7	the	the	DT
cord-104162-fe51v2pt	154	8	first	first	JJ
cord-104162-fe51v2pt	154	9	step	step	NN
cord-104162-fe51v2pt	154	10	.	.	.
cord-104162-fe51v2pt	155	1	Although	although	IN
cord-104162-fe51v2pt	155	2	the	the	DT
cord-104162-fe51v2pt	155	3	bioinformatic	bioinformatic	JJ
cord-104162-fe51v2pt	155	4	technology	technology	NN
cord-104162-fe51v2pt	155	5	related	relate	VBN
cord-104162-fe51v2pt	155	6	to	to	IN
cord-104162-fe51v2pt	155	7	this	this	DT
cord-104162-fe51v2pt	155	8	has	have	VBZ
cord-104162-fe51v2pt	155	9	long	long	RB
cord-104162-fe51v2pt	155	10	been	be	VBN
cord-104162-fe51v2pt	155	11	available	available	JJ
cord-104162-fe51v2pt	155	12	[	[	-LRB-
cord-104162-fe51v2pt	155	13	2	2	CD
cord-104162-fe51v2pt	155	14	]	]	-RRB-
cord-104162-fe51v2pt	155	15	,	,	,
cord-104162-fe51v2pt	155	16	its	-PRON-	PRP$
cord-104162-fe51v2pt	155	17	claim	claim	NN
cord-104162-fe51v2pt	155	18	to	to	TO
cord-104162-fe51v2pt	155	19	reveal	reveal	VB
cord-104162-fe51v2pt	155	20	viral	viral	JJ
cord-104162-fe51v2pt	155	21	"	"	``
cord-104162-fe51v2pt	155	22	Achilles	Achilles	NNP
cord-104162-fe51v2pt	155	23	heels	heel	NNS
cord-104162-fe51v2pt	155	24	,	,	,
cord-104162-fe51v2pt	155	25	"	"	''
cord-104162-fe51v2pt	155	26	as	as	IN
cord-104162-fe51v2pt	155	27	promulgated	promulgate	VBN
cord-104162-fe51v2pt	155	28	in	in	IN
cord-104162-fe51v2pt	155	29	successive	successive	JJ
cord-104162-fe51v2pt	155	30	textbook	textbook	NN
cord-104162-fe51v2pt	155	31	editions	edition	NNS
cord-104162-fe51v2pt	155	32	[	[	-LRB-
cord-104162-fe51v2pt	155	33	7	7	CD
cord-104162-fe51v2pt	155	34	]	]	-RRB-
cord-104162-fe51v2pt	155	35	,	,	,
cord-104162-fe51v2pt	155	36	has	have	VBZ
cord-104162-fe51v2pt	155	37	only	only	RB
cord-104162-fe51v2pt	155	38	recently	recently	RB
cord-104162-fe51v2pt	155	39	gained	gain	VBN
cord-104162-fe51v2pt	155	40	support	support	NN
cord-104162-fe51v2pt	155	41	[	[	-LRB-
cord-104162-fe51v2pt	155	42	4	4	CD
cord-104162-fe51v2pt	155	43	]	]	-RRB-
cord-104162-fe51v2pt	155	44	[	[	-LRB-
cord-104162-fe51v2pt	155	45	5	5	CD
cord-104162-fe51v2pt	155	46	]	]	-RRB-
cord-104162-fe51v2pt	155	47	[	[	-LRB-
cord-104162-fe51v2pt	155	48	6	6	CD
cord-104162-fe51v2pt	155	49	]	]	-RRB-
cord-104162-fe51v2pt	155	50	.	.	.
cord-104162-fe51v2pt	156	1	This	this	DT
cord-104162-fe51v2pt	156	2	may	may	MD
cord-104162-fe51v2pt	156	3	be	be	VB
cord-104162-fe51v2pt	156	4	because	because	IN
cord-104162-fe51v2pt	156	5	the	the	DT
cord-104162-fe51v2pt	156	6	importance	importance	NN
cord-104162-fe51v2pt	156	7	of	of	IN
cord-104162-fe51v2pt	156	8	removing	remove	VBG
cord-104162-fe51v2pt	156	9	redundant	redundant	JJ
cord-104162-fe51v2pt	156	10	information	information	NN
cord-104162-fe51v2pt	156	11	and	and	CC
cord-104162-fe51v2pt	156	12	analyzing	analyze	VBG
cord-104162-fe51v2pt	156	13	solely	solely	RB
cord-104162-fe51v2pt	156	14	the	the	DT
cord-104162-fe51v2pt	156	15	contribution	contribution	NN
cord-104162-fe51v2pt	156	16	of	of	IN
cord-104162-fe51v2pt	156	17	base	base	NN
cord-104162-fe51v2pt	156	18	order	order	NN
cord-104162-fe51v2pt	156	19	to	to	IN
cord-104162-fe51v2pt	156	20	folding	fold	VBG
cord-104162-fe51v2pt	156	21	energy	energy	NN
cord-104162-fe51v2pt	156	22	,	,	,
cord-104162-fe51v2pt	156	23	was	be	VBD
cord-104162-fe51v2pt	156	24	not	not	RB
cord-104162-fe51v2pt	156	25	fully	fully	RB
cord-104162-fe51v2pt	156	26	appreciated	appreciate	VBN
cord-104162-fe51v2pt	156	27	.	.	.
cord-104162-fe51v2pt	157	1	Thus	thus	RB
cord-104162-fe51v2pt	157	2	,	,	,
cord-104162-fe51v2pt	157	3	we	-PRON-	PRP
cord-104162-fe51v2pt	157	4	have	have	VBP
cord-104162-fe51v2pt	157	5	here	here	RB
cord-104162-fe51v2pt	157	6	repeated	repeat	VBN
cord-104162-fe51v2pt	157	7	and	and	CC
cord-104162-fe51v2pt	157	8	expanded	expand	VBN
cord-104162-fe51v2pt	157	9	on	on	IN
cord-104162-fe51v2pt	157	10	past	past	JJ
cord-104162-fe51v2pt	157	11	clarifications	clarification	NNS
cord-104162-fe51v2pt	157	12	[	[	-LRB-
cord-104162-fe51v2pt	157	13	26	26	CD
cord-104162-fe51v2pt	157	14	,	,	,
cord-104162-fe51v2pt	157	15	30	30	CD
cord-104162-fe51v2pt	157	16	,	,	,
cord-104162-fe51v2pt	157	17	31	31	CD
cord-104162-fe51v2pt	157	18	]	]	-RRB-
cord-104162-fe51v2pt	157	19	of	of	IN
cord-104162-fe51v2pt	157	20	the	the	DT
cord-104162-fe51v2pt	157	21	conceptual	conceptual	JJ
cord-104162-fe51v2pt	157	22	basis	basis	NN
cord-104162-fe51v2pt	157	23	of	of	IN
cord-104162-fe51v2pt	157	24	a	a	DT
cord-104162-fe51v2pt	157	25	technology	technology	NN
cord-104162-fe51v2pt	157	26	that	that	WDT
cord-104162-fe51v2pt	157	27	has	have	VBZ
cord-104162-fe51v2pt	157	28	contributed	contribute	VBN
cord-104162-fe51v2pt	157	29	to	to	IN
cord-104162-fe51v2pt	157	30	the	the	DT
cord-104162-fe51v2pt	157	31	understanding	understanding	NN
cord-104162-fe51v2pt	157	32	of	of	IN
cord-104162-fe51v2pt	157	33	a	a	DT
cord-104162-fe51v2pt	157	34	many	many	JJ
cord-104162-fe51v2pt	157	35	biological	biological	JJ
cord-104162-fe51v2pt	157	36	problems	problem	NNS
cord-104162-fe51v2pt	157	37	other	other	JJ
cord-104162-fe51v2pt	157	38	than	than	IN
cord-104162-fe51v2pt	157	39	viral	viral	JJ
cord-104162-fe51v2pt	157	40	infections	infection	NNS
cord-104162-fe51v2pt	157	41	[	[	-LRB-
cord-104162-fe51v2pt	157	42	7	7	CD
cord-104162-fe51v2pt	157	43	]	]	-RRB-
cord-104162-fe51v2pt	157	44	.	.	.
cord-104162-fe51v2pt	158	1	Meanwhile	meanwhile	RB
cord-104162-fe51v2pt	158	2	,	,	,
cord-104162-fe51v2pt	158	3	it	-PRON-	PRP
cord-104162-fe51v2pt	158	4	is	be	VBZ
cord-104162-fe51v2pt	158	5	pleasing	pleasing	JJ
cord-104162-fe51v2pt	158	6	to	to	TO
cord-104162-fe51v2pt	158	7	note	note	VB
cord-104162-fe51v2pt	158	8	that	that	IN
cord-104162-fe51v2pt	158	9	,	,	,
cord-104162-fe51v2pt	158	10	with	with	IN
cord-104162-fe51v2pt	158	11	minimal	minimal	JJ
cord-104162-fe51v2pt	158	12	evidence	evidence	NN
cord-104162-fe51v2pt	158	13	on	on	IN
cord-104162-fe51v2pt	158	14	targeting	targeting	NN
cord-104162-fe51v2pt	158	15	,	,	,
cord-104162-fe51v2pt	158	16	progress	progress	NN
cord-104162-fe51v2pt	158	17	is	be	VBZ
cord-104162-fe51v2pt	158	18	being	be	VBG
cord-104162-fe51v2pt	158	19	made	make	VBN
cord-104162-fe51v2pt	158	20	with	with	IN
cord-104162-fe51v2pt	158	21	the	the	DT
cord-104162-fe51v2pt	158	22	second	second	JJ
cord-104162-fe51v2pt	158	23	step	step	NN
cord-104162-fe51v2pt	158	24	[	[	-LRB-
cord-104162-fe51v2pt	158	25	9	9	CD
cord-104162-fe51v2pt	158	26	,	,	,
cord-104162-fe51v2pt	158	27	10	10	CD
cord-104162-fe51v2pt	158	28	]	]	-RRB-
cord-104162-fe51v2pt	158	29	.	.	.
cord-104162-fe51v2pt	159	1	It	-PRON-	PRP
cord-104162-fe51v2pt	159	2	is	be	VBZ
cord-104162-fe51v2pt	159	3	hoped	hope	VBN
cord-104162-fe51v2pt	159	4	that	that	IN
cord-104162-fe51v2pt	159	5	by	by	IN
cord-104162-fe51v2pt	159	6	targeting	target	VBG
cord-104162-fe51v2pt	159	7	one	one	CD
cord-104162-fe51v2pt	159	8	or	or	CC
cord-104162-fe51v2pt	159	9	more	more	JJR
cord-104162-fe51v2pt	159	10	of	of	IN
cord-104162-fe51v2pt	159	11	the	the	DT
cord-104162-fe51v2pt	159	12	conserved	conserve	VBN
cord-104162-fe51v2pt	159	13	regions	region	NNS
cord-104162-fe51v2pt	159	14	in	in	IN
cord-104162-fe51v2pt	159	15	the	the	DT
cord-104162-fe51v2pt	159	16	SARS	SARS	NNP
cord-104162-fe51v2pt	159	17	-	-	HYPH
cord-104162-fe51v2pt	159	18	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	159	19	genome	genome	NN
cord-104162-fe51v2pt	159	20	here	here	RB
cord-104162-fe51v2pt	159	21	identified	identify	VBN
cord-104162-fe51v2pt	159	22	,	,	,
cord-104162-fe51v2pt	159	23	rapid	rapid	JJ
cord-104162-fe51v2pt	159	24	cures	cure	NNS
cord-104162-fe51v2pt	159	25	will	will	MD
cord-104162-fe51v2pt	159	26	be	be	VB
cord-104162-fe51v2pt	159	27	achieved	achieve	VBN
cord-104162-fe51v2pt	159	28	.	.	.
cord-104162-fe51v2pt	160	1	Authors	author	NNS
cord-104162-fe51v2pt	160	2	declare	declare	VBP
cord-104162-fe51v2pt	160	3	no	no	DT
cord-104162-fe51v2pt	160	4	conflict	conflict	NN
cord-104162-fe51v2pt	160	5	of	of	IN
cord-104162-fe51v2pt	160	6	interest	interest	NN
cord-104162-fe51v2pt	160	7	.	.	.
cord-104162-fe51v2pt	160	8	 	 	_SP
cord-104162-fe51v2pt	161	1	Low	low	JJ
cord-104162-fe51v2pt	161	2	genetic	genetic	JJ
cord-104162-fe51v2pt	161	3	diversity	diversity	NN
cord-104162-fe51v2pt	161	4	may	may	MD
cord-104162-fe51v2pt	161	5	be	be	VB
cord-104162-fe51v2pt	161	6	an	an	DT
cord-104162-fe51v2pt	161	7	Achilles	Achilles	NNP
cord-104162-fe51v2pt	161	8	heel	heel	NN
cord-104162-fe51v2pt	161	9	of	of	IN
cord-104162-fe51v2pt	161	10	SARS	SARS	NNP
cord-104162-fe51v2pt	161	11	-	-	HYPH
cord-104162-fe51v2pt	161	12	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	161	13	Reciprocal	reciprocal	JJ
cord-104162-fe51v2pt	161	14	relationship	relationship	NN
cord-104162-fe51v2pt	161	15	between	between	IN
cord-104162-fe51v2pt	161	16	stem	stem	NN
cord-104162-fe51v2pt	161	17	-	-	HYPH
cord-104162-fe51v2pt	161	18	loop	loop	NN
cord-104162-fe51v2pt	161	19	potential	potential	NN
cord-104162-fe51v2pt	161	20	and	and	CC
cord-104162-fe51v2pt	161	21	substitution	substitution	NN
cord-104162-fe51v2pt	161	22	density	density	NN
cord-104162-fe51v2pt	161	23	in	in	IN
cord-104162-fe51v2pt	161	24	retroviral	retroviral	JJ
cord-104162-fe51v2pt	161	25	quasispecies	quasispecie	NNS
cord-104162-fe51v2pt	161	26	under	under	IN
cord-104162-fe51v2pt	161	27	positive	positive	JJ
cord-104162-fe51v2pt	161	28	Darwinian	darwinian	JJ
cord-104162-fe51v2pt	161	29	selection	selection	NN
cord-104162-fe51v2pt	161	30	Implications	implication	NNS
cord-104162-fe51v2pt	161	31	of	of	IN
cord-104162-fe51v2pt	161	32	HIV	HIV	NNP
cord-104162-fe51v2pt	161	33	RNA	RNA	NNP
cord-104162-fe51v2pt	161	34	structure	structure	NN
cord-104162-fe51v2pt	161	35	for	for	IN
cord-104162-fe51v2pt	161	36	recombination	recombination	NN
cord-104162-fe51v2pt	161	37	,	,	,
cord-104162-fe51v2pt	161	38	speciation	speciation	NN
cord-104162-fe51v2pt	161	39	,	,	,
cord-104162-fe51v2pt	161	40	and	and	CC
cord-104162-fe51v2pt	161	41	the	the	DT
cord-104162-fe51v2pt	161	42	neutralism	neutralism	NN
cord-104162-fe51v2pt	161	43	-	-	HYPH
cord-104162-fe51v2pt	161	44	selectionism	selectionism	NN
cord-104162-fe51v2pt	161	45	controversy	controversy	NN
cord-104162-fe51v2pt	162	1	An	an	DT
cord-104162-fe51v2pt	162	2	RNA	RNA	NNP
cord-104162-fe51v2pt	162	3	-	-	HYPH
cord-104162-fe51v2pt	162	4	binding	bind	VBG
cord-104162-fe51v2pt	162	5	compound	compound	NN
cord-104162-fe51v2pt	162	6	that	that	WDT
cord-104162-fe51v2pt	162	7	stabilizes	stabilize	VBZ
cord-104162-fe51v2pt	162	8	the	the	DT
cord-104162-fe51v2pt	162	9	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	162	10	gRNA	gRNA	HYPH
cord-104162-fe51v2pt	162	11	packaging	packaging	NN
cord-104162-fe51v2pt	162	12	signal	signal	NN
cord-104162-fe51v2pt	162	13	structure	structure	NN
cord-104162-fe51v2pt	162	14	and	and	CC
cord-104162-fe51v2pt	162	15	specifically	specifically	RB
cord-104162-fe51v2pt	162	16	blocks	block	VBZ
cord-104162-fe51v2pt	162	17	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	162	18	RNA	RNA	NNP
cord-104162-fe51v2pt	162	19	encapsidation	encapsidation	NN
cord-104162-fe51v2pt	163	1	The	the	DT
cord-104162-fe51v2pt	163	2	heart	heart	NN
cord-104162-fe51v2pt	163	3	of	of	IN
cord-104162-fe51v2pt	163	4	the	the	DT
cord-104162-fe51v2pt	163	5	HIV	HIV	NNP
cord-104162-fe51v2pt	163	6	RNA	RNA	NNP
cord-104162-fe51v2pt	163	7	packaging	packaging	NN
cord-104162-fe51v2pt	163	8	signal	signal	NN
cord-104162-fe51v2pt	163	9	?	?	.
cord-104162-fe51v2pt	164	1	Identification	identification	NN
cord-104162-fe51v2pt	164	2	of	of	IN
cord-104162-fe51v2pt	164	3	the	the	DT
cord-104162-fe51v2pt	164	4	initial	initial	JJ
cord-104162-fe51v2pt	164	5	nucleocapsid	nucleocapsid	NNP
cord-104162-fe51v2pt	164	6	recognition	recognition	NN
cord-104162-fe51v2pt	164	7	element	element	NN
cord-104162-fe51v2pt	164	8	in	in	IN
cord-104162-fe51v2pt	164	9	the	the	DT
cord-104162-fe51v2pt	164	10	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	164	11	RNA	RNA	NNP
cord-104162-fe51v2pt	164	12	packaging	packaging	NN
cord-104162-fe51v2pt	164	13	signal	signal	NN
cord-104162-fe51v2pt	164	14	Evolutionary	Evolutionary	NNP
cord-104162-fe51v2pt	164	15	bioinformatics	bioinformatic	NNS
cord-104162-fe51v2pt	164	16	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	164	17	Gag	Gag	NNP
cord-104162-fe51v2pt	164	18	protein	protein	NN
cord-104162-fe51v2pt	164	19	with	with	IN
cord-104162-fe51v2pt	164	20	or	or	CC
cord-104162-fe51v2pt	164	21	without	without	IN
cord-104162-fe51v2pt	164	22	p6	p6	NNP
cord-104162-fe51v2pt	164	23	specifically	specifically	RB
cord-104162-fe51v2pt	164	24	dimerizes	dimerize	VBZ
cord-104162-fe51v2pt	164	25	on	on	IN
cord-104162-fe51v2pt	164	26	the	the	DT
cord-104162-fe51v2pt	164	27	viral	viral	JJ
cord-104162-fe51v2pt	164	28	RNA	RNA	NNP
cord-104162-fe51v2pt	164	29	packaging	packaging	NN
cord-104162-fe51v2pt	164	30	signal	signal	NN
cord-104162-fe51v2pt	165	1	A	a	DT
cord-104162-fe51v2pt	165	2	small	small	JJ
cord-104162-fe51v2pt	165	3	interfering	interfere	VBG
cord-104162-fe51v2pt	165	4	RNA	RNA	NNP
cord-104162-fe51v2pt	165	5	(	(	-LRB-
cord-104162-fe51v2pt	165	6	siRNA	siRNA	NNP
cord-104162-fe51v2pt	165	7	)	)	-RRB-
cord-104162-fe51v2pt	165	8	database	database	NN
cord-104162-fe51v2pt	165	9	for	for	IN
cord-104162-fe51v2pt	165	10	SARS	SARS	NNP
cord-104162-fe51v2pt	165	11	-	-	HYPH
cord-104162-fe51v2pt	165	12	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	165	13	Targeting	target	VBG
cord-104162-fe51v2pt	165	14	the	the	DT
cord-104162-fe51v2pt	165	15	SARS	SARS	NNP
cord-104162-fe51v2pt	165	16	-	-	HYPH
cord-104162-fe51v2pt	165	17	CoV	CoV	NNP
cord-104162-fe51v2pt	165	18	2	2	CD
cord-104162-fe51v2pt	165	19	RNA	RNA	NNP
cord-104162-fe51v2pt	165	20	genome	genome	NN
cord-104162-fe51v2pt	165	21	with	with	IN
cord-104162-fe51v2pt	165	22	small	small	JJ
cord-104162-fe51v2pt	165	23	molecule	molecule	NN
cord-104162-fe51v2pt	165	24	binders	binder	NNS
cord-104162-fe51v2pt	165	25	and	and	CC
cord-104162-fe51v2pt	165	26	ribonuclease	ribonuclease	NN
cord-104162-fe51v2pt	165	27	targeting	target	VBG
cord-104162-fe51v2pt	165	28	chimera	chimera	NN
cord-104162-fe51v2pt	165	29	(	(	-LRB-
cord-104162-fe51v2pt	165	30	RIBOTAC	RIBOTAC	NNP
cord-104162-fe51v2pt	165	31	)	)	-RRB-
cord-104162-fe51v2pt	165	32	degraders	degrader	NNS
cord-104162-fe51v2pt	165	33	.	.	.
cord-104162-fe51v2pt	166	1	ACS	ACS	NNP
cord-104162-fe51v2pt	166	2	Cent	Cent	NNP
cord-104162-fe51v2pt	166	3	Sci	Sci	NNP
cord-104162-fe51v2pt	166	4	Example	Example	NNP
cord-104162-fe51v2pt	166	5	study	study	NN
cord-104162-fe51v2pt	166	6	of	of	IN
cord-104162-fe51v2pt	166	7	a	a	DT
cord-104162-fe51v2pt	166	8	highly	highly	RB
cord-104162-fe51v2pt	166	9	conserved	conserve	VBN
cord-104162-fe51v2pt	166	10	sequence	sequence	NN
cord-104162-fe51v2pt	166	11	motif	motif	NN
cord-104162-fe51v2pt	166	12	in	in	IN
cord-104162-fe51v2pt	166	13	Nsp3	Nsp3	NNP
cord-104162-fe51v2pt	166	14	of	of	IN
cord-104162-fe51v2pt	166	15	SARS	SARS	NNP
cord-104162-fe51v2pt	166	16	-	-	HYPH
cord-104162-fe51v2pt	166	17	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	166	18	as	as	IN
cord-104162-fe51v2pt	166	19	a	a	DT
cord-104162-fe51v2pt	166	20	therapeutic	therapeutic	JJ
cord-104162-fe51v2pt	166	21	target	target	NN
cord-104162-fe51v2pt	166	22	SARS	SARS	NNP
cord-104162-fe51v2pt	166	23	-	-	HYPH
cord-104162-fe51v2pt	166	24	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	166	25	and	and	CC
cord-104162-fe51v2pt	166	26	ORF3a	ORF3a	NNP
cord-104162-fe51v2pt	166	27	:	:	:
cord-104162-fe51v2pt	167	1	Nonsynonymous	nonsynonymous	JJ
cord-104162-fe51v2pt	167	2	mutations	mutation	NNS
cord-104162-fe51v2pt	167	3	,	,	,
cord-104162-fe51v2pt	167	4	functional	functional	JJ
cord-104162-fe51v2pt	167	5	domains	domain	NNS
cord-104162-fe51v2pt	167	6	,	,	,
cord-104162-fe51v2pt	167	7	and	and	CC
cord-104162-fe51v2pt	167	8	viral	viral	JJ
cord-104162-fe51v2pt	167	9	pathogenesis	pathogenesis	NN
cord-104162-fe51v2pt	167	10	Structural	structural	JJ
cord-104162-fe51v2pt	167	11	and	and	CC
cord-104162-fe51v2pt	167	12	functional	functional	JJ
cord-104162-fe51v2pt	167	13	conservation	conservation	NN
cord-104162-fe51v2pt	167	14	of	of	IN
cord-104162-fe51v2pt	167	15	the	the	DT
cord-104162-fe51v2pt	167	16	programmed	program	VBN
cord-104162-fe51v2pt	167	17	−1	−1	NNP
cord-104162-fe51v2pt	167	18	ribosomal	ribosomal	JJ
cord-104162-fe51v2pt	167	19	frameshift	frameshift	NN
cord-104162-fe51v2pt	167	20	signal	signal	NN
cord-104162-fe51v2pt	167	21	of	of	IN
cord-104162-fe51v2pt	167	22	SARS	SARS	NNP
cord-104162-fe51v2pt	167	23	coronavirus	coronavirus	NN
cord-104162-fe51v2pt	167	24	2	2	CD
cord-104162-fe51v2pt	167	25	(	(	-LRB-
cord-104162-fe51v2pt	167	26	SARS	SARS	NNP
cord-104162-fe51v2pt	167	27	-	-	HYPH
cord-104162-fe51v2pt	167	28	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	167	29	)	)	-RRB-
cord-104162-fe51v2pt	168	1	The	the	DT
cord-104162-fe51v2pt	168	2	short	short	JJ
cord-104162-fe51v2pt	168	3	-	-	HYPH
cord-104162-fe51v2pt	168	4	and	and	CC
cord-104162-fe51v2pt	168	5	long	long	JJ
cord-104162-fe51v2pt	168	6	-	-	HYPH
cord-104162-fe51v2pt	168	7	range	range	NN
cord-104162-fe51v2pt	168	8	RNA	RNA	NNP
cord-104162-fe51v2pt	168	9	-	-	HYPH
cord-104162-fe51v2pt	168	10	RNA	RNA	NNP
cord-104162-fe51v2pt	168	11	interactome	interactome	NNP
cord-104162-fe51v2pt	168	12	of	of	IN
cord-104162-fe51v2pt	168	13	SARS	SARS	NNP
cord-104162-fe51v2pt	168	14	-	-	HYPH
cord-104162-fe51v2pt	168	15	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	168	16	An	an	DT
cord-104162-fe51v2pt	168	17	in	in	IN
cord-104162-fe51v2pt	168	18	silico	silico	NN
cord-104162-fe51v2pt	168	19	map	map	NN
cord-104162-fe51v2pt	168	20	of	of	IN
cord-104162-fe51v2pt	168	21	the	the	DT
cord-104162-fe51v2pt	168	22	SARS	SARS	NNP
cord-104162-fe51v2pt	168	23	-	-	HYPH
cord-104162-fe51v2pt	168	24	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	168	25	RNA	RNA	NNP
cord-104162-fe51v2pt	168	26	structurome	structurome	NN
cord-104162-fe51v2pt	168	27	Pervasive	Pervasive	NNP
cord-104162-fe51v2pt	168	28	RNA	RNA	NNP
cord-104162-fe51v2pt	168	29	secondary	secondary	JJ
cord-104162-fe51v2pt	168	30	structure	structure	NN
cord-104162-fe51v2pt	168	31	in	in	IN
cord-104162-fe51v2pt	168	32	the	the	DT
cord-104162-fe51v2pt	168	33	genomes	genome	NNS
cord-104162-fe51v2pt	168	34	of	of	IN
cord-104162-fe51v2pt	168	35	SARS	SARS	NNP
cord-104162-fe51v2pt	168	36	-	-	HYPH
cord-104162-fe51v2pt	168	37	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	168	38	and	and	CC
cord-104162-fe51v2pt	168	39	other	other	JJ
cord-104162-fe51v2pt	168	40	coronaviruses	coronaviruse	NNS
cord-104162-fe51v2pt	169	1	An	an	DT
cord-104162-fe51v2pt	169	2	evolutionary	evolutionary	JJ
cord-104162-fe51v2pt	169	3	portrait	portrait	NN
cord-104162-fe51v2pt	169	4	of	of	IN
cord-104162-fe51v2pt	169	5	the	the	DT
cord-104162-fe51v2pt	169	6	progenitor	progenitor	NN
cord-104162-fe51v2pt	169	7	SARS	SARS	NNP
cord-104162-fe51v2pt	169	8	CoV	CoV	NNP
cord-104162-fe51v2pt	169	9	2	2	CD
cord-104162-fe51v2pt	169	10	and	and	CC
cord-104162-fe51v2pt	169	11	its	-PRON-	PRP$
cord-104162-fe51v2pt	169	12	dominant	dominant	JJ
cord-104162-fe51v2pt	169	13	offshoots	offshoot	NNS
cord-104162-fe51v2pt	169	14	in	in	IN
cord-104162-fe51v2pt	169	15	COVID	COVID	NNP
cord-104162-fe51v2pt	169	16	19	19	CD
cord-104162-fe51v2pt	169	17	pandemic	pandemic	NN
cord-104162-fe51v2pt	170	1	Assessing	assess	VBG
cord-104162-fe51v2pt	170	2	uncertainty	uncertainty	NN
cord-104162-fe51v2pt	170	3	in	in	IN
cord-104162-fe51v2pt	170	4	the	the	DT
cord-104162-fe51v2pt	170	5	rooting	rooting	NN
cord-104162-fe51v2pt	170	6	of	of	IN
cord-104162-fe51v2pt	170	7	the	the	DT
cord-104162-fe51v2pt	170	8	SARS	SARS	NNP
cord-104162-fe51v2pt	170	9	-	-	HYPH
cord-104162-fe51v2pt	170	10	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	170	11	phylogeny	phylogeny	NN
cord-104162-fe51v2pt	171	1	Different	different	JJ
cord-104162-fe51v2pt	171	2	biological	biological	JJ
cord-104162-fe51v2pt	171	3	species	specie	NNS
cord-104162-fe51v2pt	171	4	"	"	``
cord-104162-fe51v2pt	171	5	broadcast	broadcast	NN
cord-104162-fe51v2pt	171	6	"	"	''
cord-104162-fe51v2pt	171	7	their	-PRON-	PRP$
cord-104162-fe51v2pt	171	8	DNAs	dna	NNS
cord-104162-fe51v2pt	171	9	at	at	IN
cord-104162-fe51v2pt	171	10	different	different	JJ
cord-104162-fe51v2pt	171	11	(	(	-LRB-
cord-104162-fe51v2pt	171	12	G+C)%	G+C)%	NNP
cord-104162-fe51v2pt	171	13	"	"	''
cord-104162-fe51v2pt	171	14	wavelengths	wavelength	NNS
cord-104162-fe51v2pt	172	1	Success	success	NN
cord-104162-fe51v2pt	172	2	of	of	IN
cord-104162-fe51v2pt	172	3	alignment	alignment	NN
cord-104162-fe51v2pt	172	4	-	-	HYPH
cord-104162-fe51v2pt	172	5	free	free	JJ
cord-104162-fe51v2pt	172	6	oligonucleotide	oligonucleotide	XX
cord-104162-fe51v2pt	173	1	(	(	-LRB-
cord-104162-fe51v2pt	173	2	k	k	NNP
cord-104162-fe51v2pt	173	3	-	-	HYPH
cord-104162-fe51v2pt	173	4	mer	mer	NNP
cord-104162-fe51v2pt	173	5	)	)	-RRB-
cord-104162-fe51v2pt	173	6	analysis	analysis	NN
cord-104162-fe51v2pt	173	7	confirms	confirm	VBZ
cord-104162-fe51v2pt	173	8	relative	relative	JJ
cord-104162-fe51v2pt	173	9	importance	importance	NN
cord-104162-fe51v2pt	173	10	of	of	IN
cord-104162-fe51v2pt	173	11	genomes	genome	NNS
cord-104162-fe51v2pt	173	12	not	not	RB
cord-104162-fe51v2pt	173	13	genes	gene	NNS
cord-104162-fe51v2pt	173	14	in	in	IN
cord-104162-fe51v2pt	173	15	speciation	speciation	NN
cord-104162-fe51v2pt	173	16	Hybrid	hybrid	NN
cord-104162-fe51v2pt	173	17	sterility	sterility	NN
cord-104162-fe51v2pt	173	18	can	can	MD
cord-104162-fe51v2pt	173	19	only	only	RB
cord-104162-fe51v2pt	173	20	be	be	VB
cord-104162-fe51v2pt	173	21	primary	primary	JJ
cord-104162-fe51v2pt	173	22	when	when	WRB
cord-104162-fe51v2pt	173	23	acting	act	VBG
cord-104162-fe51v2pt	173	24	as	as	IN
cord-104162-fe51v2pt	173	25	a	a	DT
cord-104162-fe51v2pt	173	26	reproductive	reproductive	JJ
cord-104162-fe51v2pt	173	27	barrier	barrier	NN
cord-104162-fe51v2pt	173	28	for	for	IN
cord-104162-fe51v2pt	173	29	sympatric	sympatric	JJ
cord-104162-fe51v2pt	173	30	speciation	speciation	NN
cord-104162-fe51v2pt	173	31	A	a	DT
cord-104162-fe51v2pt	173	32	method	method	NN
cord-104162-fe51v2pt	173	33	for	for	IN
cord-104162-fe51v2pt	173	34	assessing	assess	VBG
cord-104162-fe51v2pt	173	35	the	the	DT
cord-104162-fe51v2pt	173	36	statistical	statistical	JJ
cord-104162-fe51v2pt	173	37	significance	significance	NN
cord-104162-fe51v2pt	173	38	of	of	IN
cord-104162-fe51v2pt	173	39	RNA	RNA	NNP
cord-104162-fe51v2pt	173	40	folding	folding	NNP
cord-104162-fe51v2pt	173	41	Conservation	Conservation	NNP
cord-104162-fe51v2pt	173	42	of	of	IN
cord-104162-fe51v2pt	173	43	stem	stem	NN
cord-104162-fe51v2pt	173	44	-	-	HYPH
cord-104162-fe51v2pt	173	45	loop	loop	NN
cord-104162-fe51v2pt	173	46	potential	potential	NN
cord-104162-fe51v2pt	173	47	in	in	IN
cord-104162-fe51v2pt	173	48	introns	intron	NNS
cord-104162-fe51v2pt	173	49	of	of	IN
cord-104162-fe51v2pt	173	50	snake	snake	NN
cord-104162-fe51v2pt	173	51	venom	venom	NN
cord-104162-fe51v2pt	173	52	phospholipase	phospholipase	NN
cord-104162-fe51v2pt	174	1	A	a	DT
cord-104162-fe51v2pt	174	2	2	2	CD
cord-104162-fe51v2pt	174	3	genes	gene	NNS
cord-104162-fe51v2pt	174	4	:	:	:
cord-104162-fe51v2pt	174	5	an	an	DT
cord-104162-fe51v2pt	174	6	application	application	NN
cord-104162-fe51v2pt	174	7	of	of	IN
cord-104162-fe51v2pt	174	8	FORS	FORS	NNP
cord-104162-fe51v2pt	174	9	-	-	HYPH
cord-104162-fe51v2pt	174	10	D	D	NNP
cord-104162-fe51v2pt	174	11	analysis	analysis	NN
cord-104162-fe51v2pt	174	12	Computer	Computer	NNP
cord-104162-fe51v2pt	174	13	prediction	prediction	NN
cord-104162-fe51v2pt	174	14	of	of	IN
cord-104162-fe51v2pt	174	15	RNA	RNA	NNP
cord-104162-fe51v2pt	174	16	secondary	secondary	JJ
cord-104162-fe51v2pt	174	17	structure	structure	NN
cord-104162-fe51v2pt	174	18	Calculation	calculation	NN
cord-104162-fe51v2pt	174	19	of	of	IN
cord-104162-fe51v2pt	174	20	folding	fold	VBG
cord-104162-fe51v2pt	174	21	energies	energy	NNS
cord-104162-fe51v2pt	174	22	of	of	IN
cord-104162-fe51v2pt	174	23	single	single	RB
cord-104162-fe51v2pt	174	24	-	-	HYPH
cord-104162-fe51v2pt	174	25	stranded	strand	VBN
cord-104162-fe51v2pt	174	26	nucleic	nucleic	JJ
cord-104162-fe51v2pt	174	27	acid	acid	NN
cord-104162-fe51v2pt	174	28	sequences	sequence	NNS
cord-104162-fe51v2pt	174	29	:	:	:
cord-104162-fe51v2pt	174	30	conceptual	conceptual	JJ
cord-104162-fe51v2pt	174	31	issues	issue	NNS
cord-104162-fe51v2pt	174	32	ScanFold	ScanFold	NNP
cord-104162-fe51v2pt	174	33	:	:	:
cord-104162-fe51v2pt	174	34	an	an	DT
cord-104162-fe51v2pt	174	35	approach	approach	NN
cord-104162-fe51v2pt	174	36	for	for	IN
cord-104162-fe51v2pt	174	37	genome	genome	NN
cord-104162-fe51v2pt	174	38	-	-	HYPH
cord-104162-fe51v2pt	174	39	wide	wide	JJ
cord-104162-fe51v2pt	174	40	discovery	discovery	NN
cord-104162-fe51v2pt	174	41	of	of	IN
cord-104162-fe51v2pt	174	42	local	local	JJ
cord-104162-fe51v2pt	174	43	RNA	RNA	NNP
cord-104162-fe51v2pt	174	44	structural	structural	JJ
cord-104162-fe51v2pt	174	45	elements	element	NNS
cord-104162-fe51v2pt	175	1	-applications	-applications	:
cord-104162-fe51v2pt	175	2	to	to	IN
cord-104162-fe51v2pt	175	3	Zika	Zika	NNP
cord-104162-fe51v2pt	175	4	virus	virus	NN
cord-104162-fe51v2pt	175	5	and	and	CC
cord-104162-fe51v2pt	175	6	HIV	HIV	NNP
cord-104162-fe51v2pt	175	7	A	a	DT
cord-104162-fe51v2pt	175	8	computational	computational	JJ
cord-104162-fe51v2pt	175	9	procedure	procedure	NN
cord-104162-fe51v2pt	175	10	for	for	IN
cord-104162-fe51v2pt	175	11	assessing	assess	VBG
cord-104162-fe51v2pt	175	12	the	the	DT
cord-104162-fe51v2pt	175	13	significance	significance	NN
cord-104162-fe51v2pt	175	14	of	of	IN
cord-104162-fe51v2pt	175	15	RNA	RNA	NNP
cord-104162-fe51v2pt	175	16	secondary	secondary	JJ
cord-104162-fe51v2pt	175	17	structure	structure	NN
cord-104162-fe51v2pt	175	18	Fast	fast	JJ
cord-104162-fe51v2pt	175	19	and	and	CC
cord-104162-fe51v2pt	175	20	reliable	reliable	JJ
cord-104162-fe51v2pt	175	21	prediction	prediction	NN
cord-104162-fe51v2pt	175	22	of	of	IN
cord-104162-fe51v2pt	175	23	noncoding	noncoding	JJ
cord-104162-fe51v2pt	175	24	RNAs	RNAs	NNPS
cord-104162-fe51v2pt	175	25	Evaluation	Evaluation	NNP
cord-104162-fe51v2pt	175	26	of	of	IN
cord-104162-fe51v2pt	175	27	FORS	FORS	NNP
cord-104162-fe51v2pt	175	28	-	-	HYPH
cord-104162-fe51v2pt	175	29	D	D	NNP
cord-104162-fe51v2pt	175	30	analysis	analysis	NN
cord-104162-fe51v2pt	175	31	:	:	:
cord-104162-fe51v2pt	175	32	a	a	DT
cord-104162-fe51v2pt	175	33	comparison	comparison	NN
cord-104162-fe51v2pt	175	34	with	with	IN
cord-104162-fe51v2pt	175	35	the	the	DT
cord-104162-fe51v2pt	175	36	statistically	statistically	RB
cord-104162-fe51v2pt	175	37	significant	significant	JJ
cord-104162-fe51v2pt	175	38	stem	stem	NN
cord-104162-fe51v2pt	175	39	-	-	HYPH
cord-104162-fe51v2pt	175	40	loop	loop	NN
cord-104162-fe51v2pt	175	41	potential	potential	JJ
cord-104162-fe51v2pt	175	42	A	a	DT
cord-104162-fe51v2pt	175	43	FORS	fors	NN
cord-104162-fe51v2pt	175	44	-	-	HYPH
cord-104162-fe51v2pt	175	45	D	d	NN
cord-104162-fe51v2pt	175	46	analysis	analysis	NN
cord-104162-fe51v2pt	175	47	software	software	NN
cord-104162-fe51v2pt	175	48	"	"	``
cord-104162-fe51v2pt	175	49	Random_fold_scan	random_fold_scan	JJ
cord-104162-fe51v2pt	175	50	"	"	''
cord-104162-fe51v2pt	175	51	and	and	CC
cord-104162-fe51v2pt	175	52	the	the	DT
cord-104162-fe51v2pt	175	53	influence	influence	NN
cord-104162-fe51v2pt	175	54	of	of	IN
cord-104162-fe51v2pt	175	55	different	different	JJ
cord-104162-fe51v2pt	175	56	shuffle	shuffle	NN
cord-104162-fe51v2pt	175	57	approaches	approach	NNS
cord-104162-fe51v2pt	175	58	on	on	IN
cord-104162-fe51v2pt	175	59	FORS	FORS	NNP
cord-104162-fe51v2pt	175	60	-	-	HYPH
cord-104162-fe51v2pt	175	61	D	D	NNP
cord-104162-fe51v2pt	175	62	analysis	analysis	NN
cord-104162-fe51v2pt	175	63	Low	low	JJ
cord-104162-fe51v2pt	175	64	complexity	complexity	NN
cord-104162-fe51v2pt	175	65	segments	segment	NNS
cord-104162-fe51v2pt	175	66	in	in	IN
cord-104162-fe51v2pt	175	67	Plasmodium	Plasmodium	NNP
cord-104162-fe51v2pt	175	68	falciparum	falciparum	NN
cord-104162-fe51v2pt	175	69	proteins	protein	NNS
cord-104162-fe51v2pt	175	70	are	be	VBP
cord-104162-fe51v2pt	175	71	primarily	primarily	RB
cord-104162-fe51v2pt	175	72	nucleic	nucleic	JJ
cord-104162-fe51v2pt	175	73	acid	acid	NN
cord-104162-fe51v2pt	175	74	level	level	NN
cord-104162-fe51v2pt	175	75	adaptations	adaptation	NNS
cord-104162-fe51v2pt	176	1	Microsatellites	microsatellite	NNS
cord-104162-fe51v2pt	176	2	that	that	WDT
cord-104162-fe51v2pt	176	3	violate	violate	VBP
cord-104162-fe51v2pt	176	4	Chargaff	Chargaff	NNP
cord-104162-fe51v2pt	176	5	's	's	POS
cord-104162-fe51v2pt	176	6	second	second	JJ
cord-104162-fe51v2pt	176	7	parity	parity	NN
cord-104162-fe51v2pt	176	8	rule	rule	NN
cord-104162-fe51v2pt	176	9	have	have	VBP
cord-104162-fe51v2pt	176	10	base	base	NN
cord-104162-fe51v2pt	176	11	order	order	NN
cord-104162-fe51v2pt	176	12	-	-	HYPH
cord-104162-fe51v2pt	176	13	dependent	dependent	JJ
cord-104162-fe51v2pt	176	14	asymmetries	asymmetry	NNS
cord-104162-fe51v2pt	176	15	in	in	IN
cord-104162-fe51v2pt	176	16	the	the	DT
cord-104162-fe51v2pt	176	17	folding	fold	VBG
cord-104162-fe51v2pt	176	18	energies	energy	NNS
cord-104162-fe51v2pt	176	19	of	of	IN
cord-104162-fe51v2pt	176	20	complementary	complementary	JJ
cord-104162-fe51v2pt	176	21	DNA	dna	NN
cord-104162-fe51v2pt	176	22	strands	strand	NNS
cord-104162-fe51v2pt	176	23	and	and	CC
cord-104162-fe51v2pt	176	24	may	may	MD
cord-104162-fe51v2pt	176	25	not	not	RB
cord-104162-fe51v2pt	176	26	drive	drive	VB
cord-104162-fe51v2pt	176	27	speciation	speciation	NN
cord-104162-fe51v2pt	176	28	A	a	DT
cord-104162-fe51v2pt	176	29	stem	stem	NN
cord-104162-fe51v2pt	176	30	-	-	HYPH
cord-104162-fe51v2pt	176	31	loop	loop	NN
cord-104162-fe51v2pt	176	32	"	"	``
cord-104162-fe51v2pt	176	33	kissing	kiss	VBG
cord-104162-fe51v2pt	176	34	"	"	''
cord-104162-fe51v2pt	176	35	model	model	NN
cord-104162-fe51v2pt	176	36	for	for	IN
cord-104162-fe51v2pt	176	37	the	the	DT
cord-104162-fe51v2pt	176	38	initiation	initiation	NN
cord-104162-fe51v2pt	176	39	of	of	IN
cord-104162-fe51v2pt	176	40	recombination	recombination	NN
cord-104162-fe51v2pt	176	41	and	and	CC
cord-104162-fe51v2pt	176	42	the	the	DT
cord-104162-fe51v2pt	176	43	origin	origin	NN
cord-104162-fe51v2pt	176	44	of	of	IN
cord-104162-fe51v2pt	176	45	introns	intron	NNS
cord-104162-fe51v2pt	177	1	Local	local	JJ
cord-104162-fe51v2pt	177	2	base	base	NN
cord-104162-fe51v2pt	177	3	order	order	NN
cord-104162-fe51v2pt	177	4	influences	influence	VBZ
cord-104162-fe51v2pt	177	5	the	the	DT
cord-104162-fe51v2pt	177	6	origin	origin	NN
cord-104162-fe51v2pt	177	7	of	of	IN
cord-104162-fe51v2pt	177	8	ccr5	ccr5	JJ
cord-104162-fe51v2pt	177	9	deletions	deletion	NNS
cord-104162-fe51v2pt	177	10	mediated	mediate	VBN
cord-104162-fe51v2pt	177	11	by	by	IN
cord-104162-fe51v2pt	177	12	DNA	DNA	NNP
cord-104162-fe51v2pt	177	13	slip	slip	NN
cord-104162-fe51v2pt	177	14	replication	replication	NN
cord-104162-fe51v2pt	178	1	The	the	DT
cord-104162-fe51v2pt	178	2	key	key	JJ
cord-104162-fe51v2pt	178	3	role	role	NN
cord-104162-fe51v2pt	178	4	for	for	IN
cord-104162-fe51v2pt	178	5	local	local	JJ
cord-104162-fe51v2pt	178	6	base	base	NN
cord-104162-fe51v2pt	178	7	order	order	NN
cord-104162-fe51v2pt	178	8	in	in	IN
cord-104162-fe51v2pt	178	9	the	the	DT
cord-104162-fe51v2pt	178	10	generation	generation	NN
cord-104162-fe51v2pt	178	11	of	of	IN
cord-104162-fe51v2pt	178	12	multiple	multiple	JJ
cord-104162-fe51v2pt	178	13	forms	form	NNS
cord-104162-fe51v2pt	178	14	of	of	IN
cord-104162-fe51v2pt	178	15	China	China	NNP
cord-104162-fe51v2pt	178	16	HIV-1	HIV-1	NNP
cord-104162-fe51v2pt	178	17	B'/C	B'/C	NNP
cord-104162-fe51v2pt	178	18	intersubtype	intersubtype	NN
cord-104162-fe51v2pt	178	19	recombinants	recombinant	NNS
cord-104162-fe51v2pt	178	20	Positive	Positive	NNP
cord-104162-fe51v2pt	178	21	Darwinian	darwinian	JJ
cord-104162-fe51v2pt	178	22	selection	selection	NN
cord-104162-fe51v2pt	178	23	.	.	.
cord-104162-fe51v2pt	179	1	Does	do	VBZ
cord-104162-fe51v2pt	179	2	the	the	DT
cord-104162-fe51v2pt	179	3	comparative	comparative	JJ
cord-104162-fe51v2pt	179	4	method	method	NN
cord-104162-fe51v2pt	179	5	rule	rule	NN
cord-104162-fe51v2pt	179	6	?	?	.
cord-104162-fe51v2pt	180	1	Codon	codon	NN
cord-104162-fe51v2pt	180	2	usage	usage	NN
cord-104162-fe51v2pt	180	3	and	and	CC
cord-104162-fe51v2pt	180	4	phenotypic	phenotypic	JJ
cord-104162-fe51v2pt	180	5	divergences	divergence	NNS
cord-104162-fe51v2pt	180	6	of	of	IN
cord-104162-fe51v2pt	180	7	SARS	SARS	NNP
cord-104162-fe51v2pt	180	8	-	-	HYPH
cord-104162-fe51v2pt	180	9	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	180	10	genes	gene	NNS
cord-104162-fe51v2pt	181	1	Human	human	JJ
cord-104162-fe51v2pt	181	2	immunodeficiency	immunodeficiency	NN
cord-104162-fe51v2pt	181	3	virus	virus	NN
cord-104162-fe51v2pt	181	4	type	type	NN
cord-104162-fe51v2pt	181	5	1	1	CD
cord-104162-fe51v2pt	181	6	Gag	Gag	NNP
cord-104162-fe51v2pt	181	7	polyprotein	polyprotein	NN
cord-104162-fe51v2pt	181	8	modulates	modulate	VBZ
cord-104162-fe51v2pt	181	9	its	-PRON-	PRP$
cord-104162-fe51v2pt	181	10	own	own	JJ
cord-104162-fe51v2pt	181	11	translation	translation	NN
cord-104162-fe51v2pt	181	12	Synonymous	Synonymous	NNP
cord-104162-fe51v2pt	181	13	mutations	mutation	NNS
cord-104162-fe51v2pt	181	14	and	and	CC
cord-104162-fe51v2pt	181	15	the	the	DT
cord-104162-fe51v2pt	181	16	molecular	molecular	JJ
cord-104162-fe51v2pt	181	17	evolution	evolution	NN
cord-104162-fe51v2pt	181	18	of	of	IN
cord-104162-fe51v2pt	181	19	SARS	SARS	NNP
cord-104162-fe51v2pt	181	20	-	-	HYPH
cord-104162-fe51v2pt	181	21	Cov-2	Cov-2	NNP
cord-104162-fe51v2pt	181	22	origins	origin	NNS
cord-104162-fe51v2pt	182	1	A	a	DT
cord-104162-fe51v2pt	182	2	putative	putative	JJ
cord-104162-fe51v2pt	182	3	role	role	NN
cord-104162-fe51v2pt	182	4	of	of	IN
cord-104162-fe51v2pt	182	5	de	de	JJ
cord-104162-fe51v2pt	182	6	-	-	HYPH
cord-104162-fe51v2pt	182	7	mono	mono	JJ
cord-104162-fe51v2pt	182	8	-	-	HYPH
cord-104162-fe51v2pt	182	9	ADP	adp	NN
cord-104162-fe51v2pt	182	10	-	-	HYPH
cord-104162-fe51v2pt	182	11	ribosylation	ribosylation	NN
cord-104162-fe51v2pt	182	12	of	of	IN
cord-104162-fe51v2pt	182	13	STAT1	stat1	XX
cord-104162-fe51v2pt	182	14	by	by	IN
cord-104162-fe51v2pt	182	15	the	the	DT
cord-104162-fe51v2pt	182	16	SARS	SARS	NNP
cord-104162-fe51v2pt	182	17	-	-	HYPH
cord-104162-fe51v2pt	182	18	CoV-2	CoV-2	NNP
cord-104162-fe51v2pt	182	19	Nsp3	Nsp3	NNP
cord-104162-fe51v2pt	182	20	protein	protein	NN
cord-104162-fe51v2pt	182	21	in	in	IN
cord-104162-fe51v2pt	182	22	the	the	DT
cord-104162-fe51v2pt	182	23	cytokine	cytokine	NN
cord-104162-fe51v2pt	182	24	storm	storm	NN
cord-104162-fe51v2pt	182	25	syndrome	syndrome	NN
cord-104162-fe51v2pt	182	26	of	of	IN
cord-104162-fe51v2pt	182	27	COVID-19	COVID-19	NNP
cord-104162-fe51v2pt	182	28	Two	two	CD
cord-104162-fe51v2pt	182	29	signal	signal	NN
cord-104162-fe51v2pt	182	30	half	half	JJ
cord-104162-fe51v2pt	182	31	century	century	NN
cord-104162-fe51v2pt	182	32	:	:	:
cord-104162-fe51v2pt	182	33	from	from	IN
cord-104162-fe51v2pt	182	34	negative	negative	JJ
cord-104162-fe51v2pt	182	35	selection	selection	NN
cord-104162-fe51v2pt	182	36	of	of	IN
cord-104162-fe51v2pt	182	37	self	self	NN
cord-104162-fe51v2pt	182	38	-	-	HYPH
cord-104162-fe51v2pt	182	39	reactivity	reactivity	NN
cord-104162-fe51v2pt	182	40	to	to	IN
cord-104162-fe51v2pt	182	41	positive	positive	JJ
cord-104162-fe51v2pt	182	42	selection	selection	NN
cord-104162-fe51v2pt	182	43	of	of	IN
cord-104162-fe51v2pt	182	44	near	near	JJ
cord-104162-fe51v2pt	182	45	-	-	HYPH
cord-104162-fe51v2pt	182	46	self	self	NN
cord-104162-fe51v2pt	182	47	reactivity	reactivity	NN
cord-104162-fe51v2pt	183	1	We	-PRON-	PRP
cord-104162-fe51v2pt	183	2	thank	thank	VBP
cord-104162-fe51v2pt	183	3	Prof.	Prof.	NNP
cord-104162-fe51v2pt	183	4	Shungao	Shungao	NNP
cord-104162-fe51v2pt	183	5	Xu	Xu	NNP
cord-104162-fe51v2pt	183	6	at	at	IN
cord-104162-fe51v2pt	183	7	Jiangsu	Jiangsu	NNP
cord-104162-fe51v2pt	183	8	University	University	NNP
cord-104162-fe51v2pt	183	9	for	for	IN
cord-104162-fe51v2pt	183	10	software	software	NN
cord-104162-fe51v2pt	183	11	,	,	,
cord-104162-fe51v2pt	183	12	and	and	CC
cord-104162-fe51v2pt	183	13	Ms.	Ms.	NNP
cord-104162-fe51v2pt	183	14	Le	Le	NNP
cord-104162-fe51v2pt	183	15	Cao	Cao	NNP
cord-104162-fe51v2pt	183	16	and	and	CC
cord-104162-fe51v2pt	183	17	Ms.	Ms.	NNP
cord-104162-fe51v2pt	184	1	Yingying	Yingying	NNP
cord-104162-fe51v2pt	184	2	Ma	Ma	NNP
cord-104162-fe51v2pt	184	3	at	at	IN
cord-104162-fe51v2pt	184	4	Shanghai	Shanghai	NNP
cord-104162-fe51v2pt	184	5	Public	Public	NNP
cord-104162-fe51v2pt	184	6	Health	Health	NNP
cord-104162-fe51v2pt	184	7	Clinical	Clinical	NNP
cord-104162-fe51v2pt	184	8	Center	Center	NNP
cord-104162-fe51v2pt	184	9	,	,	,
cord-104162-fe51v2pt	184	10	Fudan	Fudan	NNP
cord-104162-fe51v2pt	184	11	University	University	NNP
cord-104162-fe51v2pt	184	12	,	,	,
cord-104162-fe51v2pt	184	13	for	for	IN
cord-104162-fe51v2pt	184	14	their	-PRON-	PRP$
cord-104162-fe51v2pt	184	15	technical	technical	JJ
cord-104162-fe51v2pt	184	16	support	support	NN
cord-104162-fe51v2pt	184	17	.	.	.
cord-104162-fe51v2pt	185	1	Queen	Queen	NNP
cord-104162-fe51v2pt	185	2	's	's	POS
cord-104162-fe51v2pt	185	3	University	University	NNP
cord-104162-fe51v2pt	185	4	hosts	host	NNS
cord-104162-fe51v2pt	185	5	Forsdyke	Forsdyke	NNP
cord-104162-fe51v2pt	185	6	's	's	POS
cord-104162-fe51v2pt	185	7	webpages	webpage	NNS
cord-104162-fe51v2pt	185	8	.	.	.
cord-104162-fe51v2pt	186	1	The	the	DT
cord-104162-fe51v2pt	186	2	bioRxiv	bioRxiv	NNP
cord-104162-fe51v2pt	186	3	server	server	NN
cord-104162-fe51v2pt	186	4	hosts	host	VBZ
cord-104162-fe51v2pt	186	5	preprints	preprint	NNS
cord-104162-fe51v2pt	186	6	.	.	.