id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355541-5sctqkwr	Alcamí, José	Current situation in the development of a preventive HIV vaccine	2005-07-31		.txt	text/plain	7258	310	39	This review analyses the major challenges in developing an aids vaccine, in particular the mechanisms involved in viral escape from the immune response, and summarizes the results obtained with the different prototypes of therapeutic and preventive vaccines. In order to develop a vaccine, it is necessary to know the genes of the pathogen involved in the induction of a specific immune response, and to use experimental models to test the efficacy of the virus. The most conclusive experimental data on the role of the cellular response in the control of viral replication come from studies in which selective depletion of CD8 lymphocytes in macaques infected with SIV leads to a huge increase in viremia and accelerated evolution to aids 22 . These types of preparation have failed as preventive vaccines in animal models, since they have not achieved protective immunity, probably due to the fact that the humoral response induced against HIV proteins is erratic and of reduced potency.	./cache/cord-355541-5sctqkwr.txt	./txt/cord-355541-5sctqkwr.txt