id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354790-xx6imhzb	Lambour, Jennifer	Converting monoclonal antibody-based immunotherapies from passive to active: bringing immune complexes into play	2016-08-17		.txt	text/plain	6499	324	33	31 In addition to controlling the viral propagation by these mechanisms, the opsonization of viral particles and/or infected cells by therapeutic antiviral mAbs of the IgG type leads to the formation of immune complexes (ICs) recognizable by the FcγRs expressed on antigen-presenting cells (APCs) such as DCs. This can potentially affect the endogenous antiviral adaptive immune response of passive immunotherapy-treated individuals. Moreover, as the in vivo activity of anti-HIV-1 bNAbs, including viral load control, was recently shown to crucially depend on Fc effector functions, 53,54 an important issue is identifying that Fc-FcγRs interactions are involved in the induction of vaccinelike effects by antiviral mAbs. To understand the mechanisms underlying the enhancement of antiviral responses by ICs, several in vitro studies have addressed whether antibody-mediated viral uptake by DCs could lead to stronger activation of these cells and the development of stronger virus-specific CD4 + and CD8 + T-cell responses in an Fc-dependent manner.	./cache/cord-354790-xx6imhzb.txt	./txt/cord-354790-xx6imhzb.txt