id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354050-kcn67stj	Shi, Guoli	More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins	2017-11-21		.txt	text/plain	6846	313	36	Most of what we know about the antiviral activities of IFITM proteins results from work using IAV and vesicular stomatitis virus (VSV), which perform pH-dependent fusion reactions in endosomes to gain access to the cell interior [22] . As the primary determinant for virus-cell attachment and the subsequent fusion reaction, the viral envelope glycoprotein (Env) was suspected to play an important role in whether or not HIV-1 and related lentiviruses are subject to inhibition by IFITM proteins. In addition to restricting virus entry, recent findings indicate that IFITM proteins perform antiviral functions impacting late stages of the HIV-1 life cycle. This antiviral activity is enhanced upon expression of an IFITM3 mutant that is defective for endocytosis, indicating that restriction of HIV-1 virion infectivity is performed at the plasma membrane [5] . Nonetheless, the recent identification of Env variants that are resistant to the IFITM3-mediated restriction of virion infectivity confirms this viral protein as an important determinant.	./cache/cord-354050-kcn67stj.txt	./txt/cord-354050-kcn67stj.txt