id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349358-leicos9j	Ketzinel‐Gilad, Mali	RNA interference for antiviral therapy	2006-06-16		.txt	text/plain	12734	684	44	During the past few years, it has been demonstrated that RNAi, induced by specifically designed double‐stranded RNA (dsRNA) molecules, can silence gene expression of human viral pathogens both in acute and chronic viral infections. Likewise, expression vectors of siRNAs specific for two different regions of the WNV genome protected 293T cells from WNV infection, and significantly reduced viral RNA replication and virus production [35] . From the reports on the use of siRNA against human viral pathogens causing acute disease, we could learn that for each specific pathogen infecting a specific cell lineage or tissue, we would probably need to perform an indepth assessment, with proper in vitro and in vivo models, and develop specific delivery systems. The most challenging part of RNAi approaches for chronic viral infections is to design the best delivery method that would facilitate the targeting of the specific organ/cells with the appropriate expression system, for durable intracellular levels of gene-silencing effect.	./cache/cord-349358-leicos9j.txt	./txt/cord-349358-leicos9j.txt