id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348409-oxjd263z	Stern, Zachariah	The development of inovirus-associated vector vaccines using phage-display technologies	2019-09-08		.txt	text/plain	6043	315	41	Areas covered: The architectural traits of filamentous viruses and their derivatives, IAVs, facilitate the display of specific antigenic peptides which induce antibody production to prevent or curtail infection. The creation of Random Peptide Libraries (RPL), where random oligopeptides are fused to major capsid proteins (gp3 or gp8) and displayed on individual inovirus clones creating a random variety of IAVs which can be used for vaccine design via epitope mapping using monoclonal or polyclonal antibodies. Through this breakthrough technology which was the subject matter of the Nobel Prize in Chemistry 2018 (see 'Expert Commentary' below), inovriuses displaying oligopeptides mimicking antigens (or specific epitopes of an antigen) can be used to vaccinate hosts thus inducing the desired antibody production. Unlike previous studies, which used a single specific peptide fused to a inovirus, four different antigenic peptides were displayed by inoviruses in a cocktail of recombinant IAVs. The induction of a cellular response completely vaccinated 1/3 of the pigs in the study and reduced the number of cysticerci in all other pigs [61] .	./cache/cord-348409-oxjd263z.txt	./txt/cord-348409-oxjd263z.txt