id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342936-43u7afl3	Balzarini, Jan	Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy	2007		.txt	text/plain	11304	534	44	Perhaps more importantly, such carbohydrate-binding agents (CBAs) may force the virus to delete at least part of its glycan shield to escape drug pressure 5 ; this might result in the initiation of an immune response against uncovered immunogenic envelope epitopes. Although such a mechanism may be efficient for a first-line inactivation of HIV, CBA-exposed HIV strains may decrease the efficiency of LCs to eliminate HIV, but at the same time may compromise the ability of the virus to be efficiently transmitted by DCs. The interactions of several CBAs have been extensively investigated, including: the prokaryotic CV-N and actinohivin; a variety of plant lectins, including Hippeastrum hybrid agglutinin (HHA) and UDA; the non-peptidic low-molecular-weight antibiotic PRM-A; and the monoclonal antibody 2G12 with the HIV-envelope gp120 and/or several glycan structures.	./cache/cord-342936-43u7afl3.txt	./txt/cord-342936-43u7afl3.txt