id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338594-wft7yy6j	Winkler, Michael	Rhesus macaque IFITM3 gene polymorphisms and SIV infection	2017-03-03		.txt	text/plain	4633	277	48	In particular, polymorphisms of the human IFITM3 gene have been shown to affect disease severity and progression in influenza A virus (FLUAV) and human immunodeficiency virus (HIV) infection, respectively. Employing previously characterized samples from two cohorts of SIV-infected rhesus macaques, we investigated the relationship between these rhIFITM3 polymorphisms and both AIDS-free survival time and virus load. Polymorphisms in several immune-relevant gene loci such as MHC or KIR are associated with the transmission and course of disease in SIV infected rhesus macaques and HIV-1 infected humans [36, 37] . Immune-related IFITM proteins have been established as important antiviral effectors of the interferon response, and a polymorphism in the human IFITM3 gene has been found to be associated with disease severity and progression in FLUAV and HIV-1 infection [27, 33] . Notably, all polymorphism in the coding region were silent and strong evidence for an association of rhIFITM3 polymorphisms with disease progression and viral load in SIV infected animals was not obtained.	./cache/cord-338594-wft7yy6j.txt	./txt/cord-338594-wft7yy6j.txt