id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337458-dc90ecfe	Markwalter, Christine F.	Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics	2018-12-04		.txt	text/plain	40568	2391	40	In this review, we define the components of a diagnostic to include: (1) the target biomarker, an endogenous indicator of a disease state, which is most often a pathogen or host protein, carbohydrate, or nucleic acid sequence, (2) sample preparation, which allows for biomarker isolation, purification, and/or concentration from complex biological matrices, (3) molecular recognition elements, which specifically capture and detect the target biomarker, (4) signal generation and amplification, and (5) instrumentation for signal read-out. 113, 114 In subsequent studies, the group developed and optimized a hand-held, easy-to-use device 85, 115 (Figure 8A ) in which HRP2-bound, IMAC-functionalized magnetic beads were directly transferred to the sample pad of commercial malaria lateral flow assays. If combined with one of the sample preparation strategies discussed previously (section 3) or integrated with paper or another field-ready substrate, this Ir(III)-based detection strategy could produce a robust and sensitive assay that is applicable in low-resource diagnostic settings.	./cache/cord-337458-dc90ecfe.txt	./txt/cord-337458-dc90ecfe.txt