id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329396-cl28bjnd	Carrico, Adam W.	Double Jeopardy: Methamphetamine Use and HIV as Risk Factors for COVID-19	2020-04-07		.txt	text/plain	2317	109	40	In our prior bio-behavioral research conducted with MSM with treated HIV infection who use meth, those who provided a urine sample that was reactive for stimulants (i.e., meth or cocaine) displayed differential expression of genes and 2-directional perturbation of pathways relevant to systemic immune activation and inflammation [25] . The clinical relevance of these findings is supported by the fact that markers of systemic immune activation and inflammation are implicated in multiple, chronic medical conditions such as cardiovascular disease in people living with HIV, which have been identified as key risk factors for COVID-19 progression [28, 29] . Smoking is a prevalent mode of administration for meth and crack-cocaine that could enhance local immune dysregulation in the lungs and modify the expression of ACE-2 receptors to increase vulnerability to SARS-CoV-2 infection and COVID-19 progression. Further clinical research is needed to characterize the psychiatric consequences of the COVID-19 pandemic and test novel mHealth approaches to improve adherence to social distancing guidelines in MSM who use meth and other stimulants.	./cache/cord-329396-cl28bjnd.txt	./txt/cord-329396-cl28bjnd.txt