id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329361-0mpbau1b	Bennasser, Yamina	RNAi Therapy for HIV Infection: Principles and Practicalities	2012-08-16		.txt	text/plain	2645	200	56	Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses. [4] Hence, in plants and Drosophila, when a cell they have sequence specificity for silencing mRNAs, these small is infected by a virus, an RNAi response is triggered by the foreign RNAs potentially represent a future class of antiviral drugs. [42] silencing of viral RNA and transient suppression of HIV replicaobserved that an siRNA targeted to nef rapidly elicited the emertion over a period of 3 to 4 days in single round infection of gence of siRNA-resistant viruses with point mutations in the nef cultured cells have been achieved.	./cache/cord-329361-0mpbau1b.txt	./txt/cord-329361-0mpbau1b.txt