id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-327324-4c4a4bfz	Wilkinson, Robert J	Tuberculosis and type 2 Diabetes Mellitus: an inflammatory danger signal in the time of COVID-19	2020-06-13		.txt	text/plain	872	61	43	title: Tuberculosis and type 2 Diabetes Mellitus: an inflammatory danger signal in the time of COVID-19 Active tuberculosis has a transcriptomic signature dominated by a neutrophil-driven type 1 and 2 interferoninducible gene profile. The exaggerated inflammation that characterizes HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is triggered by Toll-like receptor and inflammasome signalling [14] . Male sex and diabetes have been identified in virtually every study as risk factors for severe COVID-19 infection, associated in the largest study to date with an adjusted hazard ratio for in-hospital death of 1.99 (male sex) and 1.50 for controlled (HbA1c < 58 mmol/mol) and 2.36 for uncontrolled DM [18] . Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis	./cache/cord-327324-4c4a4bfz.txt	./txt/cord-327324-4c4a4bfz.txt