id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-327135-4c2flue4	Chinnaswamy, S	Gene–disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections	2016-06-09		.txt	text/plain	9813	499	48	Interferon (IFN) lambda (IFN-λ or type III IFN) gene polymorphisms were discovered in the year 2009 to have a strong association with spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection in human hosts. Three independent groups conducted genome-wide association studies (GWASs) involving treatment response to chronic hepatitis C virus (HCV) infections, in three different geographical regions of the world, and reported that single-nucleotide polymorphisms (SNPs) in the IFNL locus (Figure 1 ), had strong association with treatment-induced HCV clearance irrespective of ethnicity and geographical location of the hosts. 49 In stark contrast, a dominant model of inheritance (of the non-beneficial IFNL SNP minor allele) has consistently given the best explanation on the observed phenotypes in association studies with both spontaneous clearance and IFN-based treatment response in chronic HCV infections.	./cache/cord-327135-4c2flue4.txt	./txt/cord-327135-4c2flue4.txt