id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326558-6tss9ydx	Chen, Jiao	A binning tool to reconstruct viral haplotypes from assembled contigs	2019-11-04		.txt	text/plain	6709	429	54	CONCLUSIONS: In this work, we presented VirBin, a new contig binning tool for distinguishing contigs from different viral haplotypes with high sequence similarity. These methods usually estimate the bin number by aligning metagenomic data to a pre-established marker gene database, and then assign assembled contigs to different bins using sequence composition information and read coverage levels. We evaluate the haplotype number estimation and clustering performance of VirBin on both simulated and mock HIV quasispecies sequencing data. It uses bowtie2 to map reads to a set of universal genes and infers the within-species strains abundances by Fig. 3 The recall and precision of contig binning results by MaxBin. X-axis represents each haplotype, in decreasing order of relative abundance. Although abundance-based clustering has been used for contig binning from multiple samples [15, 19] , existing tools are not designed Fig. 7 The pipeline of VirBin to tackle key challenges of distinguishing contigs of different haplotypes.	./cache/cord-326558-6tss9ydx.txt	./txt/cord-326558-6tss9ydx.txt