id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324690-82qsirnk	Dieffenbach, Carl W	The search for an HIV vaccine, the journey continues	2020-05-16		.txt	text/plain	1469	73	51	Over the past decade, three different vaccine approaches have been implemented, possible correlates of protection identified, and two have moved through clinical evaluation to advanced clinical trials. Analysis of the correlates of protection seen in the non-human primate studies point to qualitatively different responses than those observed in RV144, and the trials are evaluating in silico designed immunogens to present the most globally conserved HIV sequences to trigger quantitatively superior CD8 + T cell responses [8, 9] . The Antibody Mediated Protection (AMP) trials are currently evaluating VRC01, the CD4 binding site targeted bNAb, to determine the ability of this single antibody to prevent HIV infection in women in Southern Africa and MSM and transgender persons in the Americas [13] . The authors thank the trial participants, community members, activists and researchers who have so willingly participated in the challenging work of HIV vaccine discovery and development.	./cache/cord-324690-82qsirnk.txt	./txt/cord-324690-82qsirnk.txt