id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319354-jbain7n6	Gondim, Ana C. S.	Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity	2019-01-14		.txt	text/plain	4052	201	52	For example, lectins from Bryothamnion triquetrum (BTL) and Bryothamnion seaforthii (BSL) have been used to differentiate human colon carcinoma cell variants, 10 while the algal (cyanobacterial) lectin cyanovirin-N (CV-N) shows not only potent antiviral activity against HIV-1 and HIV-2, but also against influenza virus and Ebola virus. Given the potent anti-HIV activity of several lectins, and their pronounced effect on syncytium formation in SupT1-HUT-78/HIV-1 co-cultures, the binding of the lectins to the HIV-1 envelope glycoproteins gp120 and gp41 and the cellular CD4 receptor was investigated by surface plasmon resonance (SPR) technology. The leguminous lectins (DLasiL, DSclerL, ConBr, ConM) appeared to show higher binding to the three glycoproteins than the algal (SfL, HML) lectins (Table S1 †) . Thus, these and other lectins might act as antiviral compounds efficiently preventing viral entry into the host cells, which generally occurs through specific interactions of the lectins with glycans exposed on the gp120 (and gp41) glycoproteins (in the case of HIV) of the virus surface.	./cache/cord-319354-jbain7n6.txt	./txt/cord-319354-jbain7n6.txt