id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319116-2ts6zpdb	Ruggiero, Emanuela	G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy	2018-04-20		.txt	text/plain	9124	410	42	Since the number of reports describing the presence of G4s in virus genomes has boomed in the past 2 years and treatment with several G4 ligands has shown potentially interesting therapeutic activity, we here aim at presenting, organizing and discussing an up-to-date close-up of the literature on G4s in viruses and the classes of molecules that have shown antiviral activity by viral G4 targeting. The research of G4s in the HIV-1 genome has been quite productive, concerning not only the two RNA viral genome copies, but also the integrated proviral genome, specifically For each virus the following information is shown: virion structure and dimension, genome size and organization; schematic representation of the G4 (red dots) location in the viral genomes or in the mRNA and G4 binding proteins; number of G4s assessed through bioinformatics analysis, according to the corresponding references; G4 ligands reported to date to display antiviral effect and corresponding references.	./cache/cord-319116-2ts6zpdb.txt	./txt/cord-319116-2ts6zpdb.txt