id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319043-hczwgf6o	Ashkenazi, Avraham	Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1	2012-08-07		.txt	text/plain	5676	309	50	We hypothesized that by minimizing the affinity of the peptides to the viral fusion site (using short fragments from the core); we would mainly identify the contribution of the conjugated lipid moiety to antiviral activity. This exclusive inhibitory activity of sphinganine-based peptides (sphingopeptides) was further observed in a wider spectrum of viral entry systems, consisting of different HIV strains (wildtype HXB2 and LAI) and different target cells (TZM-bl reporter cells and Jurkat T cells), as well as in cell-cell fusion assay (Fig. 2) . Thus, we hypothesized that its dihydrosphingosine (sphinganine) backbone may penetrate into the site of membrane fusion mediated by the HIV Env. To investigate this, we conjugated sphinganine as well as other lipids to short, otherwise inert, peptides from the HIV-1 Env core and their antiviral activities were investigated in several types of HIV-1 infection assays.	./cache/cord-319043-hczwgf6o.txt	./txt/cord-319043-hczwgf6o.txt