id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315687-stgj6olw	Demma, LJ	Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host	2006-03-20		.txt	text/plain	6439	322	46	To characterize this intra-host SIV diversity, we performed sequence analyses of clonal viral envelope (env) V1V2 and gag p27 variants present in individual SIVsm-infected sooty mangabeys over time. Although phylogenetic analyses of SIV sequences reveal considerable viral genetic diversity between different infected individuals [19] , the magnitude of intra-animal viral diversity, the substrate for selection in cross-species transmission events, has not been studied. The pre-existence of viral env variants in naturally infected SMs that are capable of replicating to high levels in a new host species pointed to the importance of SIVsm diversity in the reservoir host in enabling cross-species transmission. Here we describe extraordinarily high intra-host SIVsm env V1V2 diversity in naturally infected SMs, maintained by its high replication rate and positive selection most likely mediated by antibody responses. The similar levels of viral variation may also indicate that selective forces acting on env V1V2 are comparable in both SIVsm-infected natural mangabey reservoir hosts and in HIV-infected humans.	./cache/cord-315687-stgj6olw.txt	./txt/cord-315687-stgj6olw.txt