id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314528-5yq95giq	Hirayama, Makoto	High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120	2015-12-12		.txt	text/plain	8228	437	56	title: High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120 We previously reported that a high-mannose binding lectin KAA-2 from the red alga Kappaphycus alvarezii, which is an economically important species and widely cultivated as a source of carrageenans, had a potent anti-influenza virus activity. They consisted of four internal tandem-repeated domains, which are conserved in high-mannose specific lectins from lower organisms, including a cyanobacterium Oscillatoria agardhii and a red alga Eucheuma serra. alvarezii preferentially recognized high-mannose-type oligosaccharides bearing an exposed α1-3 Man at the nonreducing end in D2 arm and inhibited infection of various influenza virus strains with EC 50 s of low nanomolar levels through direct binding to the viral envelope hemagglutinin protein, which has several high-mannose N-glycans (Sato et al.	./cache/cord-314528-5yq95giq.txt	./txt/cord-314528-5yq95giq.txt