id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314098-1i6c0l3e	Hayward, Joshua A	Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity	2018-03-29		.txt	text/plain	6805	379	50	Several bat APOBEC3 proteins are antiviral as demonstrated by restriction of retroviral infectivity using HIV-1 as a model, and recombinant A3Z1 subtypes possess strong DNA deaminase activity. In this study, pteropid A3 loci were generated through the step-wise extension of cDNA-mapped gene scaffolds followed by remapping of sequence read archives, supported experimentally by an A3 expression analysis of bat spleen tissue. The antiviral activity of bat A3 proteins was determined by assessing the capacity of representatives of each bat A3 subtype to restrict HIV-1 infectivity in target cells. doi:10.1093/molbev/msy048 MBE Ancient Bat Retroviruses Were Hypermutated by APOBEC3 A3 activity results in C to U lesions in the negative (cDNA) strand, which lead to positive (genomic) strand G to A mutations in endogenous retroviruses (ERVs) within host genomes (Perez-Caballero et al.	./cache/cord-314098-1i6c0l3e.txt	./txt/cord-314098-1i6c0l3e.txt