id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306050-y8i8759c	García, Juan Ignacio	Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala	2020-10-19		.txt	text/plain	5288	263	48	title: Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala The aim of the study is to evaluate the performance of the lipoarabinomannan antigen test (LAM-test) with and without α-mannosidase pre-treated urine in a cohort of PLWH in primary care clinics in Guatemala. A composite reference standard of either a positive Mycobacterium tuberculosis complex culture and/or GeneXpert(®) MTB/RIF (Xpert, Cepheid, Sunnyvale, CA, USA) results was used in the LAM-test diagnostic accuracy studies. We also determined if a 30 min α-mannosidase pre-treatment of urine using an enzyme that removes the mannose caps of LAM could improve the sensitivity of the LAM-test as we have shown in the laboratory settings [14] , and further correlated LAM-test results with TB incidence, mortality rates, and risk factors in our cohort of PLWH.	./cache/cord-306050-y8i8759c.txt	./txt/cord-306050-y8i8759c.txt