id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304794-z2kx314h	Métifiot, Mathieu	G-quadruplexes in viruses: function and potential therapeutic applications	2014-11-10		.txt	text/plain	9102	490	47	Conversely, a G-quadruplex or G4 is formed by nucleic acid sequences (DNA or RNA) containing G-tracts or Gblocks (adjacent runs of guanines) and composed of various numbers of guanines. Short RNA templates from the central region of the HIV-1 genome contain G-rich sequences near the central polypurine tract (cPPT) at the 3 end of the pol gene (IN coding sequence); this is a region where one of the two primers used for synthesizing the (−) strand DNA is produced during reverse transcription. In addition, one could imagine alternative therapeutic strategies focused on targeting RNA structures within viral ORFs to interfere with the virus cycle as well as to promote antigen presentation and to stimulate the host immune response. Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development U3 Region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence	./cache/cord-304794-z2kx314h.txt	./txt/cord-304794-z2kx314h.txt