id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304214-66nxk4e8	Sanders, John W.	Vectored immunoprophylaxis: an emerging adjunct to traditional vaccination	2017-02-10		.txt	text/plain	3742	173	36	Rather than passively transfering pre-formed antibodies, VIP is a process in which genes encoding previously characterized neutralizing antibodies are vectored into non-hematopoietic cells which then secrete the monoclonal antibodes encoded by those genes [1] (See Fig. 1 .) This vectored delivery and production of specified antibodies allows for protection without generating a standard immune response and results in endogenous antibody production that has the potential to be sustained [9] . Saunders, et al., used an rAAV serotype 8 vector to produce a full length IgG of a simianized form of the broadly neutralizing antibody VRC07 in macaques which was protective against simian-human immunodeficiency virus (SHIV) infection 5.5 weeks after treatment [24] . Using HIV-1-infected humanized mice, Horwitz, et al., demonstrated that following initial treatment with anti-retroviral therapy (ART), a single injection of adeno-associated virus directing expression of broadly neutralizing antibody 10-1074, produced durable viremic control after the ART was stopped [26] .	./cache/cord-304214-66nxk4e8.txt	./txt/cord-304214-66nxk4e8.txt