id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304188-1nm1tbig	Moody, M. Anthony	Modulation of HIV-1 immunity by adjuvants	2014-04-10		.txt	text/plain	5154	249	43	Although no vaccine formulation has yet succeeded in eliciting broad neutralizing antibodies against HIV-1, the ability of adjuvants to direct the immune response to immunogens suggests they will be critically important in any successful HIV-1 vaccine. This is accomplished in one of two ways -through the incorporation of active compounds in a vaccine formulation (e.g., formulating a protein immunogen in a liposome containing a TLR4 agonist) or by incorporating elements in the vaccine that result in the production of immune stimulants (e.g., addition of plasmids expressing cytokines in a DNA vaccine regimen). [12] reported in 1993 on another group of chimpanzees immunized with formaldehyde-inactivated HIV-1 adjuvanted with alum, Freund's incomplete adjuvant (an oil-in-water emulsion), or with a zinc hydroxide/lecithin-based adjuvant; in this study, antibody titers were best with the lecithin-based adjuvant, although proliferation and antibodydependent cell-mediated cytotoxicity (ADCC) responses were similar between lecithin and alum arms.	./cache/cord-304188-1nm1tbig.txt	./txt/cord-304188-1nm1tbig.txt