id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302530-pp6bl941	Gale, Paul	How virus size and attachment parameters affect the temperature sensitivity of virus binding to host cells: Predictions of a thermodynamic model for arboviruses and HIV	2020-03-12		.txt	text/plain	14797	905	66	These are:-1 The predicted effect of the magnitude of ΔC p on the temperature dependence of Dengue virus (DENV) transmission by Aedes albopictus; 2 The predicted effect of the magnitude of ΔC p on the temperature peak observed for the specific binding of Western equine encephalitis virus (WEEV) to susceptible Culex tarsalis brush border fragments (BBFs); 3 A large negative ΔC p for a protein:protein GP/Cr system as represented by HIV gp120:CD4 diminishes host cell binding at human body temperature; 4 A large virus diameter as for the HIV virion diminishes host cell binding at the higher temperature of the human body through the large negative ΔS a_immob ; 5 Non-specific attachment factors may partially overcome the unfavourable ΔS a_immob and hence enhance specific HIV binding through Env:CD4 interactions at human body temperature; and 6 Increasing the number, n, of GP/Cr contacts with temperature to reproduce the data of Frey et al.	./cache/cord-302530-pp6bl941.txt	./txt/cord-302530-pp6bl941.txt