id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302082-aaokc182	Stanberry, Lawrence R.	Vaccines of the future	2011-08-31		.txt	text/plain	7736	348	37	To address these challenges researchers are exploring many avenues: novel adjuvants are being developed that enhance the immune response elicited by a vaccine while maintaining high levels of tolerability; methods of protective antigen identification are iterated with every success; vaccine storage and transport systems are improving (including optimising the cold chain and developing temperature-stable vaccines); and new and potentially more convenient methods of vaccine administration are being pursued. One approach to addressing the weak immunogenicity of the antigen has been to link it to a potent Toll-like receptor adjuvant such as flagellin, an approach developed by VaxInnate Inc. During primary infection of a single individual with HIV, mutations in surface proteins of the virus lead to selection of a 'cloud' of antigenic variants that can evade the cell-mediated immune responses complicating the development of broadly effective vaccines.	./cache/cord-302082-aaokc182.txt	./txt/cord-302082-aaokc182.txt