id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295290-hs5ntlok	Atlan, H.	Mechanisms of autoimmunity and AIDS: prospects for therapeutic intervention	1994-12-31		.txt	text/plain	9832	424	38	Based on this hypothesis, a T-cell vaccination procedure against effector T cells responsible for autoimmunopathic activity in HIV-seropositive patients is proposed, similar to the one known from experimental study of autoimmunity and presently being tested in human autoimmune diseases. These include cross-reactive recognition of self-MHC and a secondary antiidiotypic response to CD4, to be found in the first large set of references mentioned above, elimination of infected T4 cells by virus-specific, HLArestricted cytotoxic lymphocytes (Shearer, 1986; Zinkernagel, 1988) , elimination of uninfected T4 cells by immune responses directed against HIV (Klatzmann and Gluckman, 1986; Salk, 1987; Lyerly et al., 1987; Lanzavecchia et al., 1988; Lanzavecchia, 1989 ; Siliciano et al., 1988 ; Israel-Biet et al., 1990 ; Morrow et al., 1991) and/or T4 cell antigens (Stricker et al., 1987; Martinez-A. Autoimmunopathic destruction of T4 cells might thus result, in this case, from the destabilization of a self-tolerance-maintaining regulatory network by immune responses to HIV components with homologies to antigens normally present on T4 cells.	./cache/cord-295290-hs5ntlok.txt	./txt/cord-295290-hs5ntlok.txt