id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294366-swwz4kzd	Bramwell, Vincent W.	The rational design of vaccines	2005-11-15		.txt	text/plain	4880	200	31	By definition of perceived need, we are most acutely aware of the requirement of effective vaccines against infectious agents, pathogens ancient, re-emergent and new, yet the opportunities for manipulation of immune responses offer potential in the prevention and treatment of a far larger diversity of diseases. For example, the level of protection required in a population (herd immunity) will be different and this could allow theoretical flexibility in vaccine efficacy.The application of molecular biology techniques can be crucial in the identification of new candidate antigens and subsequent determination of vaccine efficacy using adjuvants can feed knowledge back to correlates of protection in terms of immunological markers.This knowledge can then be used in choice of appropriate adjuvants and formulation.The key implication projected by this schematic is that for the greatest challenges in vaccine development the cyclical generation of knowledge provides a strong role for rational design.	./cache/cord-294366-swwz4kzd.txt	./txt/cord-294366-swwz4kzd.txt