id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292740-b4cdj96q	Wahid, Braira	Immunotherapeutic strategies for sexually transmitted viral infections: HIV, HSV and HPV	2016-08-03		.txt	text/plain	10099	516	34	Within initial three months of infection, high concentration of antibodies is developed against different viral proteins in HIV-1 infected patients and recent studies unfolded that antibodies, CD8+ T cell activity, and CD4+ helper responses lead to control of HIV virus. Replication defective recombinant adenovirus 5 vector with HIV-1 clade B nef/gag/pol inserts was the first T-cell vaccine that underwent clinical efficacy trials and exhibited significant increase in CD8+ T cell but these CD8+ immune responses targeted the variable but not the conserved regions of virus. Immunomodulators include both immunosuppressive and immunostimulatory agents that trigger secretion of cytokines from macrophages (IL-12, IFN-12, TNF-a) leading to increased Th1 response, antibody production in response to improved antigen presentation by dendritic cells, and cell-mediated immunity which is being used clinically to cure viral infections like herpes simplex virus, human papillomavirus and cancerous lesions in immunocompromised individuals [136] .	./cache/cord-292740-b4cdj96q.txt	./txt/cord-292740-b4cdj96q.txt