id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287286-4l963z2q	Green, Victoria A.	Molecular mechanisms of viral infection and propagation: An overview of the second Advanced Summer School in Africa	2010-07-28		.txt	text/plain	7368	363	43	The main themes of discussion at the summer school were: 1) why viral infection can lead to cancer; 2) how a greater understanding of the mechanisms underpinning human immunodeficiency virus (HIV) propagation can inform new antiviral strategies; 3) the abilities of viruses to evade the immune system and the obstacles to the development of effective vaccines; and, 4) the potential afforded by viruses as research tools. The import of the host, including an ability to regulate viral gene expression in different tissues and to mount an effective immune response, is becoming increasingly apparent in determining the molecular basis of HPV-associated tumor progression. Advantages CoVs possess over other viruses as expression vectors include: 1) the possibility of spike protein manipulation, to engineer virus tropism (88, 89) ; 2) the replication of the RNA genome in the cytoplasm, side-stepping potential problems associated with integration (90); 3) the existence of nonpathogenic strains that infect a wide range of species of health and economic importance; 4) the ability to carry large genomes (27-30 kb) , which could favor the introduction of extensive foreign genes (91); and 5) the availability of cDNA clones derived from infectious strains (92, 93) .	./cache/cord-287286-4l963z2q.txt	./txt/cord-287286-4l963z2q.txt