id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281941-97t45w73	Zhou, Daijun	Cyclophilin A and viral infections	2012-08-10		.txt	text/plain	3410	184	43	A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc. Thus, CyPA plays a suppressive role in the development of CD4 + T cell responses through its interaction with Itk. In recent years many studies showed that CyPA was involved in the pathogenesis of viral infection [8] , cardiovascular disease [9] and cancer [10] . The viral protein R (Vpr) of HIV-1 is the major virion-associated accessory protein that affects a number of biological functions in the retroviral life cycle, including promotion of the transport of the pre-integration complex into the nucleus and the induction of G2 host cell cycle arrest [20] . Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex	./cache/cord-281941-97t45w73.txt	./txt/cord-281941-97t45w73.txt