id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272051-arz8r204	Federico, Maurizio	HIV-protease inhibitors block the replication of both vesicular stomatitis and influenza viruses at an early post-entry replication step	2011-08-15		.txt	text/plain	6772	320	49	Since the replication of many virus species requires the activity of host cell proteases, investigating the effects of PIs on the life cycle of viruses other than HIV would be of interest. Considering that PIs are well tolerated drugs in vivo, and that many relevant human pathogens belong to the family of RNA viruses infecting cells through an endocytic pathway, this finding would open the way towards a broader therapeutic use of PIs. HIV virions emerging from cells treated with PIs remain immature viral particles as a consequence of the block of Gag polyprotein cleavage. Cells were treated overnight with the PI doses most effective against VSV and/or influenza virus replication, then labeled with LysoSensor Green DND-189 for 30 min in the presence of PIs, and finally analyzed by FACS.	./cache/cord-272051-arz8r204.txt	./txt/cord-272051-arz8r204.txt