id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271948-iq29xqrn	Obeng, Billal Musah	Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana	2020-07-24		.txt	text/plain	3572	203	56	title: Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana BACKGROUND: Detection of HIV-1 transmitted drug resistance (TDR) and subtype diversity (SD) are public health strategies to assess current HIV-1 regimen and ensure effective therapeutic outcomes of antiretroviral therapy (ART) among HIV-1 patients. In this study, drug resistance mutations (DRMs) and SD amongst HIV-1 sero-positive blood donors in Accra, Ghana were characterized. The data obtained would inform the selection of drugs for ART initiation to maximize therapeutic options in drug-naïve HIV-1 patients in Ghana. This study found major drug resistance mutations, E138A and K65R that respectively confer high level resistance to NNRTIs and NRTIs. Although, CRF02_AG was most predominant, the recorded percentage of subtype B and the evolutionary relationship inferred by phylogenetic analysis may suggest possible subtype importation. The data obtained is useful for the selection of drugs for ART initiation to maximize therapeutic outcomes in drug-naïve HIV-1 patients in Ghana.	./cache/cord-271948-iq29xqrn.txt	./txt/cord-271948-iq29xqrn.txt