id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271241-w1q46y63	Ruggiero, Emanuela	Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy	2020-05-18		.txt	text/plain	8912	495	45	Since the genomes of viruses are remarkably variable, high conservation rates strongly suggest a crucial role of G4s in the viral replication cycle and evolution, emphasizing the possibility of targeting viral G4s as a new pharmacological approach in antiviral therapy. 1 In the past few decades, pharmaceutical and biotechnological advance has succeeded in developing new therapeutics for the management of different viral diseases: for example, anti-retroviral therapy against the human immunodeficiency virus (HIV), or the pan-genotypic direct-acting antiviral drugs used for hepatitis C (HCV) management. In addition, such PQSs are highly conserved, despite the high recombination rates that characterize viruses, suggesting a crucial role for G4s in viral evolution and replication, and corroborating their targeting as a valid pharmacological approach for antiviral therapy.	./cache/cord-271241-w1q46y63.txt	./txt/cord-271241-w1q46y63.txt