id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270726-w59fu9c9	Dikman, Andrew E.	Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy	2015-03-14		.txt	text/plain	5191	279	43	The etiology of noninfectious diarrhea in patients with HIV is multifactorial and includes ART-associated diarrhea and gastrointestinal damage related to HIV infection (i.e., HIV enteropathy). A basic algorithm for the diagnosis of diarrhea in patients with HIV includes physical examination, a review of medical history, assessment of HIV viral load and CD4+ T cell count, stool microbiologic assessment, and endoscopic evaluation, if needed. In addition, these agents can be associated with treatment-limiting adverse events (AEs), such as drug–drug interactions with ART regimens, abuse liability, and additional gastrointestinal AEs. Currently, crofelemer, an antisecretory agent, is the only therapy approved in the USA for the symptomatic relief of noninfectious diarrhea in patients with HIV on ART. While infection has historically been the major cause of diarrhea in patients with HIV, with the widespread use of ART therapy, noninfectious diarrhea has become a burden in this population.	./cache/cord-270726-w59fu9c9.txt	./txt/cord-270726-w59fu9c9.txt