id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264050-6zpw6itb	Pirofski, Liise-anne	Immune-Mediated Damage Completes the Parabola: Cryptococcus neoformans Pathogenesis Can Reflect the Outcome of a Weak or Strong Immune Response	2017-12-12		.txt	text/plain	2752	121	36	The demonstration that host-mediated damage can drive cryptococcal disease provides proof of concept that the parabola put forth in the damage-response framework has the flexibility to depict complex and changing outcomes of host-microbe interaction. However, the emergence of Cryptococcus gattii in apparently healthy persons in the Pacific Northwest (7) and the unexpected appearance of immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcosis in patients with HIV/AIDS after initiation of antiretroviral therapy (ART) (8, 9) revealed that the host immune response itself can contribute to the pathogenesis of cryptococcosis. The emergence of IRIS-associated cryptococcosis in the setting of ART initiation provided clear evidence that host damage in patients with cryptococcal disease may be driven by inflammation (12) . Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patients with cryptococcal meningitis and cryptococcosis-associated immune reconstitution inflammatory syndrome	./cache/cord-264050-6zpw6itb.txt	./txt/cord-264050-6zpw6itb.txt