id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261382-cyty5noi	Goffinet, Christine	Cellular Antiviral Factors that Target Particle Infectivity of HIV-1	2016-05-17		.txt	text/plain	4084	177	35	Whereas well-established restriction factors interfere with early post-entry steps and release of HIV-1, recent research has revealed a diverse set of proteins that reduce the infectious quality of released particles using individual, to date poorly understood modes of action. Alternatively, alteration of the virus membrane fluidity, restriction of the accessibility of the HIV-1 Env glycoprotein to the HIV-1 receptor/coreceptor complex by steric hindrance through an incorporated protein or inhibition of the maturation-induced clustering of HIV-1 Env trimers could represent mechanisms of cellular defense that target particle infectivity. Since it shares mRNA upregulation in CD4+ T-cells of HIV-1 infected individuals [11] and type I IFN-induced expression [10, 12, 13] with established restriction factors of HIV-1, it was included in a functional screen of candidate ISGs for antiviral activity (Goffinet, unpublished data). Additional family members, including IFITM5, whose expression is restricted to osteoblasts [22] , and 10 additional, recently discovered human ifitm genes [21] probably do not contribute to inhibition of HIV-1 infection or haven't yet been tested for antiviral activity, respectively.	./cache/cord-261382-cyty5noi.txt	./txt/cord-261382-cyty5noi.txt