id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260604-lz1qd69t	Singh, Ramendra K.	Synthesis, structure–activity relationship and antiviral activity of 3′-N,N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs	2010-09-30		.txt	text/plain	3096	170	58	Molecular docking studies with HIV-1 RT using DS 2.5 and pymol softwares have shown marked differences in the interaction patterns between the lead compound 4 and AZT. The lead molecule, DMAT, was designed keeping AZT, an approved NRTI drug against HIV/AIDS, in mind, where azido group has been replaced by dimethylamino function, Fig. 1 . Compounds 4 and 5 have showed similar values of CC 50 and EC 50 against all viruses studied and thus no activity was observed, while 5 0 -L-phenylalanyl derivative 6, having free amino function was potentially active at an EC 50 of 0.03 mM against VSV in HeLa and HEL cell cultures. The fact that the lead molecule DMAT (and its prodrugs) being a dideoxynucleoside and having structural features similar to AZT, did not show any activity against HIV and rather proved toxic, prompted us to study its interaction with HIV-1 RT.	./cache/cord-260604-lz1qd69t.txt	./txt/cord-260604-lz1qd69t.txt