id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256477-dftt5m6i	Feller, John M.	Potential Ebola prophylaxis	2015-07-01		.txt	text/plain	604	43	53	The hypothesis that CQ might afford Ebola prophylaxis comes from our own work showing hydroxychloroquine (HCQ) induces apoptosis (programmed cell death) in peripheral blood mononuclear cells. 4, 5 A randomised controlled trial (RCT) in 13 ART-naïve patients found CQ was associated with decreased memory CD8 T-cell activation, CD4 and CD8 T-cell proliferation and lipopolysaccharide levels compared with baseline, but there were no changes in plasma HIV RNA. 6 However, another RCT of HCQ in ART-naïve patients demonstrated no change in T-cell activation and proliferation, an increase in HIV RNA and a decrease in CD4 T-cell counts. Ebola infects dendritic cells, which display signals of infection on their surfaces to activate T lymphocytes that destroy other infected cells before the virus replicates further. Reduction of immune activation with chloroquine therapy during chronic HIV infection Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial	./cache/cord-256477-dftt5m6i.txt	./txt/cord-256477-dftt5m6i.txt