id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254190-bxfne94u	Tu, Wenwei	Application of Humanized Mice in Immunological Research	2015-07-07		.txt	text/plain	6246	254	34	On the contrary, humanized mice established by peripheral blood cells provide a ready platform for studying the functions of mature immune cells but the length of window appropriate for research is still limited by chronic GVHD and ongoing reduced engraftment. Distinct from their T cell companion, reconstitution of functional B lymphocytes is generally poor in humanized mice and needed to improve in the future although their primary repertoire were principally unaltered by the differences between mouse and human stromal environments [ 53 ] and their ability to produce antigen-specifi c antibody was partly developed [ 54 ] . In above three studies, investigators planted solid grafts into immunodefi cient mice before reconstitution of human immune system and induced rejection by infusion of mature human cells. Humanized immune system (HIS) mice as a tool to study human NK cell development Humanized mice as a model to study human hematopoietic stem cell transplantation	./cache/cord-254190-bxfne94u.txt	./txt/cord-254190-bxfne94u.txt